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Sample records for causadas por uveitis

  1. causada por Fusarium moniliforme

    Directory of Open Access Journals (Sweden)

    Mariano Mendoza Elos

    2006-01-01

    Full Text Available El objetivo de éste trabajo fue determinar la resistencia horizontal de 134 líneas S1 de maíz al hongo Fusarium moniliforme. La enfermedad fue inducida mediante inoculación en la etapa de floración masculina bajo condiciones de campo utilizando la técnica del palillo. Las líneas se evaluaron en México en 2002. La estimación de la enfermedad se hizo en dos ocasiones con una separación de 20 días. Las evaluaciones mostraron que las líneas Roque-801, 804, 1103 y 1405 fueron resistentes en la primera evaluación. Las tasas de incremento de la enfermedad variaron de 0,01 a 0,229 por unidad por día. Las líneas mostraron bajos niveles de enfermedad de 0 a 1 % en la primera evaluación. En la segunda evaluación, los niveles de enfermedad variaron de 49 a 100 %. En un programa de mejoramiento genético estas líneas pueden ser utilizadas para mejorar la resistencia horizontal del maíz a la pudrición del tallo causada por Fusarium moniliforme

  2. Ptose palpebral causada por Paquidermoperiostose

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    Patricia Regina de Pinho Tavares

    2014-08-01

    Full Text Available A paquidermoperiostose é uma síndrome caracterizada por acometimento cutâneo e ósseo, e em alguns casos ocorre comprometimento palpebral leve. É uma síndrome rara, idiopática ou hereditária, com provável herança autossômica dominante de penetrância variável. Descreve-se o caso de um paciente com ptose grave por paquidermoperiostose elucidando sua fisiopatologia e conduta cirúrgica aplicada.

  3. Endocardite infecciosa causada por Eikenella corrodens

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    Cardoso Juliano Novaes

    2005-01-01

    Full Text Available Os microorganismos do grupo HACEK (Haemophilus spp, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens e Kingella kingae são responsáveis por 3% dos casos de endocardites. Eles apresentam propriedades clínicas e microbiológicas semelhantes entre si: são bacilos gram-negativos, isolados mais facilmente em meios aeróbicos, suas culturas necessitam de tempo prolongado de incubação para crescimento (média 3,3 dias e podem ser considerados como parte da flora normal do trato respiratório superior e da orofaringe1,2. Algumas características foram identificadas nas endocardites por esses agentes, como o quadro clínico insidioso¹, diagnóstico difícil pela natureza fastidiosa e culturas negativas3,4. A endocardite por Eikenella corrodens foi descrita pela primeira vez em 1972(5 e continua sendo um agente etiológico raro. Relatamos o caso de uma paciente com valva nativa que apresentou endocardite infecciosa causada por Eikenella corrodens.

  4. Síndrome oculoglandular de Parinaud causada por esporotricose

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    Ribeiro,Alexandre Sampaio de Abreu; Bisol,Tiago; Menezes,Marcela Sant'Ana

    2010-01-01

    A síndrome oculoglandular de Parinaud é uma doença ocular rara causada por diferentes agentes etiológicos, entre eles bactérias, vírus e fungos. É caracterizada por uma conjuntivite granulomatosa, acompanhada de linfadenopatia pré-auricular adjacente e pode trazer sequelas caso não seja prontamente tratada. Neste artigo é relatado o caso de uma jovem técnica de enfermagem e estudante de medicina veterinária apresentando a síndrome oculoglandular de Parinaud causada pelo fungo Sporothrix schen...

  5. Hemorragia cerebral causada por enfermedad de la membrana hialina

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    Iglesias Rozas, José Rafael, 1942-

    1982-01-01

    Seis imágenes de una hemorragia cerebral en un neonato causada por la enfermedad de la membrana hialina (también conocida como síndrome de dificultad respiratoria neonatal). Six pictures of a cerebral hemorrhage in a neonate caused by the hyaline membrane disease (also known as neonatal respiratory distress syndrome).

  6. Uveitis

    Science.gov (United States)

    Iritis; Pars planitis; Choroiditis; Chorioretinitis; Anterior uveitis; Posterior uveitis; Iridocyclitis ... Uveitis can be caused by autoimmune disorders . These diseases occur when the body's immune system attacks and ...

  7. Uveitis

    Science.gov (United States)

    ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics Center ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics Center ...

  8. Peracute bovine mastitis caused by Klebsiella pneumoniae Mastite bovina hiperaguda causada por Klebsiella pneumoniae

    OpenAIRE

    Ribeiro,M.G.; R.G. Motta; A.C. Paes; S.D. Allendorf; Salerno,T.; Siqueira, A.K. [UNESP; Fernandes, M.C. [UNESP; Lara, G.h.b [UNESP

    2008-01-01

    Relata-se a ocorrência de graves sintomas de mastite hiperaguda em vaca, causada por Klebsiella pneumoniae, na terceira semana de lactação. Descrevem-se aspectos epidemiológicos, sintomas clínicos, procedimentos de diagnóstico microbiológico, conduta terapêutica e medidas de controle.

  9. Peracute bovine mastitis caused by Klebsiella pneumoniae Mastite bovina hiperaguda causada por Klebsiella pneumoniae

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    M.G. Ribeiro

    2008-04-01

    Full Text Available Relata-se a ocorrência de graves sintomas de mastite hiperaguda em vaca, causada por Klebsiella pneumoniae, na terceira semana de lactação. Descrevem-se aspectos epidemiológicos, sintomas clínicos, procedimentos de diagnóstico microbiológico, conduta terapêutica e medidas de controle.

  10. Mastitis bovina causada por Staphylococcus coagulasa negativos

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    Bonetto, César C.

    2014-01-01

    El presente Trabajo de Tesis se desprende como una línea de investigación del grupo de la UNRC dedicado al estudio de la problemática de la mastitis bovina tanto en aspectos básicos como aplicados con estudios genéticos, epidemiológicos y de virulencia de los principales microorganismos involucrados en la mastitis bovina. Staphylococccus coagulasa negativo (SCN) es un grupo bacteriano formado por varias especies que por lo general eran considerados flora oportunista de la piel y age...

  11. La podredumbre del cuello del sorgo causada por Fusarium verticilloides

    OpenAIRE

    Galvez Patón, Laura; Paris de la Rosa, M.; Cordes, G.; Iglesias Gonzalez, Concepcion; Palmero Llamas, Daniel

    2012-01-01

    El sorgo anual ha sido clasificado por de Wet (1978) como Sorghum bicolor (L.) Moench (2n=20) subespecie bicolor, con 5 razas básicas: bicolor, guinea, caudatum, kafir y durra, las que incluyen los distintos tipos de sorgo existentes en el mercado como los graniferos, los forrajeros tipo sudán, dulces y escoberos (Giorda y Cordes, 2005).

  12. Reações adversas causadas por antiparkinsonianos

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    Lopes, Mariana Aparecida; Tanaka, Érica Mayumi; Nishiyama, Paula

    2012-01-01

    A Doença de Parkinson (DP) acomete geralmente a população idosa que em sua maioria apresenta múltiplos problemas de saúde e faz uso de vários medicamentos, havendo assim uma grande probabilidade da ocorrência de eventos adversos. Este trabalho tem como objetivo identificar e caracterizar os medicamentos utilizados e as reações adversas apresentadas por portadores deste agravo, atendidos pelo Programa de Medicamentos Excepcionais (PME) da 15a Regional de Saúde do Paraná. O estudo foi realizado...

  13. Lesiones en el hombro causadas por electrocución

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    Herrero Barcos, L.; Martínez Martín, Angel Antonio; Herrera Rodríguez, Antonio; Cuenca Espiérrez, Jorge; Panisello Sebastiá, Juan José

    2001-01-01

    Las lesiones en el hombro tras sufrir una descarga eléctrica son raras. Presentamos siete pacientes con luxaciones y fracturas en el hombro debidas a una electrocución. Un alto porcentaje de estas lesiones se diagnostican tarde, empeorando de esta manera el pronóstico. Por ello, ante una electrocución, debemos pensar en una lesión de hombro. Shoulder injuries after an electrical shock are rare. We report seven cases with dislocation and fractures of the shoulder due to electrocution. A hig...

  14. Severe gangrene by cold agglutinemia Gangrena grave causada por crioaglutinina

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    Perla Vicari

    2004-03-01

    Full Text Available The cold agglutinin syndrome is a haemolytic disorder usually manifested by acrocyanosis and Raynaud's phenomenon. Gangrene is an uncommon complication, usually associated with infections or B-cell lymphoproliferative diseases. We present a case of fulminant gangrene of fingers, toes, and nose in a 77-year-old woman with atypical pneumonia and acute renal failure. The diagnosis of haemolytic anaemia with cold agglutinin syndrome was done and the treatment with antibiotics and corticosteroids was effective. However, amputation of all the toes on both feet could not be avoided. Clinical aspects of cold agglutinemia, transient or chronic, are briefly discussed. We conclude that, in the presence of cold agglutinin syndrome, the treatment should be promptly initiated in order to avoid complications such as extensive gangrene.Doença da aglutinina a frio é uma patologia caracterizada pela produção de anticorpos contra antígenos específicos da membrana eritrocitária, geralmente de classe IgM, que aglutinam hemácias em temperaturas abaixo de 32º C. Relatamos um caso de gangrena e insuficiência renal em uma mulher de 77 anos com pneumonia atípica. Anemia hemolítica secundária a crioaglutininas foi observada. O tratamento com antibióticos e corticóides foi eficaz com regressão do quadro, porém foi necessária a amputação de todos os dedos do pé (falanges bilateralmente, preservando o restante dos pés (tarsos e metatarsos. Anemia hemolítica secundária a crioaglutininas manifesta-se freqüentemente por acrocianose e fenômeno de Raynaud. Gangrena é uma complicação incomum dessa doença, principalmente quando secundária a etiologia infecciosa, sendo observada apenas em pacientes com altos títulos persistentes. Está correlacionada freqüentemente com causa infecciosa (Mycoplasma spp, vírus Epstein-Barr, citomegalovírus, vírus Influenza A, adenovírus, Legionella spp, linfoproliferativas B e idiopáticas. Suspeita clínica de

  15. Meningite e endocardite infecciosa causada por Rhodotorula mucilaginosa em paciente imunocompetente

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    Sergio Henrique Loss

    2011-12-01

    Full Text Available Os autores relatam o caso de um homem imunocompetente admitido com comprometimento agudo do sistema nervoso, crise hipertensiva e insuficiência renal, vindo a receber diagnóstico de meningite e endocardite infecciosa por Rhodotorula mucilaginosa. Até onde sabemos, esta é a primeira descrição de infecção simultânea das meninges e do endotélio causada por Rhodotorula em um paciente sem comprometimento imunológico.

  16. Tratamento laparoscópico de periapendicite causada por dispositivo intra-uterino

    OpenAIRE

    2003-01-01

    RACIONAL: Dispositivo intra-uterino pode perfurar o útero e causar várias complicações. OBJETIVO: Descrever um caso de tratamento laparoscópico de periapendicite causada por dispositivo intra-uterino. MATERIAL E MÉTODOS: Jovem do sexo feminino apresentou dor em fossa ilíaca direita de 4 dias de duração. No exame físico, apresentava dor abdominal localizada em fossa ilíaca direita, com discreta renitência de parede e dor à percussão e descompressão brusca na região. A ultra-sonografia evidenci...

  17. Tratamiento de una depresión causada por pérdida afectiva : caso único

    OpenAIRE

    2002-01-01

    Este artículo presenta la intervención terapéutica en un caso de depresión grave, causada fundamentalmente por pérdida afectiva. La cliente, de 26 años, sufre una ruptura de una relación sentimental. Después de 2 meses de la ruptura, la paciente manifiesta síntomas depresivos como insomnio, pérdida de peso, llanto constante, falta de concentración, irritabilidad y sentimientos de culpa. Asimismo, se puso de manifiesto una fuerte resistencia a aceptar la ruptura. ...

  18. Tratamento laparoscópico de periapendicite causada por dispositivo intra-uterino

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    Coelho Júlio Cezar Uili

    2003-01-01

    Full Text Available RACIONAL: Dispositivo intra-uterino pode perfurar o útero e causar várias complicações. OBJETIVO: Descrever um caso de tratamento laparoscópico de periapendicite causada por dispositivo intra-uterino. MATERIAL E MÉTODOS: Jovem do sexo feminino apresentou dor em fossa ilíaca direita de 4 dias de duração. No exame físico, apresentava dor abdominal localizada em fossa ilíaca direita, com discreta renitência de parede e dor à percussão e descompressão brusca na região. A ultra-sonografia evidenciou dispositivo intra-uterino fora do útero, na fossa ilíaca direita. RESULTADOS: À laparoscopia, observou-se massa inflamatória que consistia do dispositivo intra-uterino totalmente bloqueado pelo mesoapêndice e apêndice. Apendicectomia e retirada do dispositivo foram realizadas. CONCLUSÃO: A laparoscopia permite o tratamento adequado da periapendicite causada por dispositivo intra-uterino, inclusive com avaliação adequada de toda a região pélvica para excluir lesões associadas.

  19. Primer caso de onicomicosis causada por Cylindrocarpon lichenicola, en un paciente inmunosuprimido en Costa Rica

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    Mauricio Lizano-Calvo

    2013-12-01

    Full Text Available Antecedentes: la onicomicosis es una infección fúngica de las uñas, que puede ser causada por dermatofitos, levaduras y hongos filamentosos no dermatofitos. El objetivo del presente trabajo fue identificar -morfológica y molecularmente- un aislamiento realizado a partir de la uña del dedo medio de la mano derecha de un paciente inmunosuprimido con trasplante renal. Métodos: a la muestra se le realizó un examen microscópico directo en KOH 40%, y las características de la colonia fueron evaluadas en medio de cultivo Agar Sabouraud Glucosado y Agar Mycosel. El hongo aislado se identificó molecularmente mediante la amplificación, por reacción en cadena de la polimerasa (PCR y secuenciación de la región espaciadora transcrita (ITS de los genes ribosomales y de una porción del gen del factor de elongación 1alfa (EF-1α. La secuencia de nucleótidos de cada región fue comparada con las secuencias publicadas en la base de datos del Banco de Genes del Centro Nacional para la Información Biotecnológica (NCBI. Resultados: las características macro y microscópicas de la colonia concordaron con las descritas para Cylindrocarpon lichenicola (sinónimo Fusarium lichenicola. La secuencia de nucleótidos, tanto de la región ITS (544 pb como de la porción del gen EF-1α (710 pb, presentó un 100% de similitud con secuencias de F. lichenicola. Conclusión: se identificó por primera vez en Costa Rica C. lichenicola asociado con onicomicosis en un paciente inmunosuprimido. Este tipo de pacientes deben ser instruidos sobre las posibles fuentes de agentes infecciosos.

  20. Estado de la moniliasis del cacao causada por Moniliophthora roreri en Colombia

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    Javier Correa Álvarez

    2014-12-01

    Full Text Available La moniliasis es una enfermedad fúngica que ataca el cultivo de cacao, causada por el basidiomycete Moniliophthora roreri. Está presente en la mayoría de los países latinoamericanos y se adapta a diversidad de ambientes. En Colombia la enfermedad es devastadora y las estrategias de control tradicional han generado resultados colaterales como el fortalecimiento de la resistencia genética de cepas del hongo en algunas regiones. En esta revisión, se recopilan los aspectos biológicos y agronómicos más relevantes del hongo, entre ellos, origen y distribución, ciclo de vida, formas de control y trabajos de investigación realizados con el fin de entender la genética y evolución de este patógeno. Finalmente, se propone incrementar el número de estudios en investigación básica, con miras a entender cómo ha sido la evolución de su genoma en hábitats que favorecen la variación genética. Con este conocimiento se podría avanzar en programas biotecnológicos de control y prevención de la enfermedad.

  1. Trauma de genitália externa masculina causada por maquinaria

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    Marcelo Cabral Lamy de Miranda

    2008-03-01

    Full Text Available Descrevemos um caso de trauma de genitália externa masculina causado por maquinaria tipo roçadeira com bom resultado final. O paciente J.R.A., 26 anos, trabalhador rural, apresentou evento traumático à tração de suas vestes causada por maquinaria, gerando trauma escrotal e testicular direito grau V, trauma escrotal esquerdo grau V, trauma testicular esquerdo grau II, trauma de pênis grau III, com ausência de lesão uretral. O tratamento consistiu em avaliação inicial por cirurgião geral, com posterior avaliação e conduta operatória urológica através de limpeza e desbridamento dos tecidos desvitalizados, ligadura do cordão espermático do lado direito, com introdução em subcutâneo na raiz da coxa esquerda do testículo ipsilateral preservado. Após seis meses realizou-se reconstrução da genitália pela cirurgia plástica através de técnica de colocação de retalho da coxa direita juntamente com músculo grácil. O paciente recebeu alta hospitalar no décimo dia pós-operatório, com melhora visual da estética do órgão, assim como melhora funcional, apresentando episódios de ereção durante a internação. Teve como seqüela reprodutiva azoospermia. Concluímos que em casos de trauma severo com várias lesões associadas em genitália externa masculina, deve-se optar por tratamento cirúrgico com boas perspectivas de retorno de sua função fisiológica. Descritores: genitália masculina, pênis, testículos, ferimentos e lesões, acidentes de trabalho.

  2. PUDRICIÓN BASAL CAUSADA POR Phytophthora capsici EN PLANTAS DE CHILE TRATADAS CON VERMICOMPOST

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    Lidieth Uribe-Lor\\u00EDo

    2014-01-01

    Full Text Available Pudrición basal causada por Phytophthora capcisi en plantas de chile tratadas con vermicompost. El objetivo de este trabajo fue evaluar a nivel de invernadero el efecto de vermicompost sobre la incidencia y severidad de Phytophthora capcisi en plantas de chile (Capsicum annuum. Esta investigación se realizó entre febrero y marzo del 2012 en el Centro de Investigaciones Agronómicas, Sabanilla, San José, Costa Rica. Se utilizó un diseño completamente al azar con cuatro repeticiones y ocho plantas por unidad experimental en un arreglo factorial con los factores de dosis (0, 25% y 50% v/v vermicompost:suelo e inoculación (0 y 500 zoosporas por gramo de suelo. Se trasplantaron plántulas de 35 días, que fueron inoculadas dos semanas después del trasplante. La aplicación de vermicompost provocó un aumento significativo del peso fresco foliar y del peso seco foliar y radical; a mayor dosis, mayor fue el incremento. Las plantas de todos los tratamientos que incluyeron inoculación con P. capsici presentaron síntomas de la enfermedad en la raíz. Los valores de incidencia y severidad fueron mayores para el tratamiento con 50% de abono. En este tratamiento se presentaron síntomas de marchitez. La ausencia de diferencias en las variables de peso fresco y seco entre los tratamientos inoculados y sin inocular, a los que se adicionó abono al 25%, sugiere que esta dosis podría compensar el daño causado por el patógeno. Se observó una menor concentración de nutrimentos en los tejidos de las plantas inoculadas lo que indica que el daño causado a la raíz pudo haber afectado la adquisición de nutrimentos.

  3. Perdas causadas por Coccus viridis (Hemiptera: Coccidae em mudas de Coffea arabica L.

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    Flávio Lemes Fernandes

    2009-08-01

    Full Text Available Coccus viridis (Green danifica plantas jovens e adultas de Coffea arabica Linnaeu. No entanto, nada se sabe sobre a magnitude dos danos causados por esta praga. Assim, este trabalho teve por objetivo estudar as relações entre o ataque de C. viridis e as perdas causadas por este inseto a C. arabica. Este trabalho foi conduzido em casa de vegetação na Universidade Federal de Viçosa. Foram utilizadas sementes da linhagem IAC 15 da variedade “Catuaí vermelho” de café (C. arabica. Para a confecção dos tratamentos esta praga foi criada em casa de vegetação separada do experimento. Os tratamentos foram: plantas infestadas e não infestadas por adultos e ninfas da cochonilha verde. As plantas foram nutridas com solução nutritiva. Durante 110 dias foram avaliados: números de adultos e de ninfas de primeiro, segundo e terceiro ínstares, área foliar, diâmetro do caule, altura das plantas em todas repetições. No final do experimento avaliou-se o peso das raízes, caule, folhas e total. Os pesos das raízes, matéria seca total, área foliar e diâmetro do caule de plantas não atacadas por C. viridis superaram em 1,31; 1,41; 1,50 e 8,93 vezes, respectivamente o peso de plantas atacadas. As variáveis selecionadas foram: diâmetro do caule (cm, área foliar (cm², peso de raízes (g, ninfas, adultos e total das cochonilhas. Concluindo que a planta de C. arabica é afetada de forma diferente entre seus órgãos e que a ninfa de terceiro ínstar e adultos são as fases que mais causam danos a C. arabica.Losses Caused by Coccus viridis (Green (Hemiptera: Coccidae on Seedlings of Coffea arabica L.Abstract. Coccus viridis (Green cause losses on seedling and old plants of Coffea arabica (Green. However, nothing is known about of the damages caused by this pest. Thus, the objective of this work was to evaluate the relations between atack of C. viridis and the losses caused by this insect. on C. arabica. This work was conduced in greenhouse at

  4. Pneumopatia causada por Mycobacterium kansasii Lung disease caused by Mycobacterium kansasii

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    Nelson Morrone

    2003-12-01

    Full Text Available INTRODUÇÃO: O Mycobacterium kansasii é uma micobactéria não tuberculosa que pode causar colonização ou infecção pulmonar. OBJETIVO: Relatar experiência com doença pulmonar causada pelo M. kansasii em uma série de seis pacientes diagnosticados ao longo de cinco anos. MÉTODO: Entre junho de 1995 e junho de 2000 foram admitidos 1.349 pacientes no Dispensário do Ipiranga Ari Nogueira da Silva-Sanatorinhos, com o diagnóstico de tuberculose pulmonar, dos quais seis tiveram cultura positiva para M. kansasii. RESULTADOS: Cinco pacientes eram homens e a idade variou entre 25 e 77 anos. Todos apresentavam pneumopatia crônica e eram sintomáticos respiratórios com teste negativo para síndrome de imunodeficiência humana. As radiografias de tórax eram compatíveis com a presença de doença pulmonar prévia: cavidades de paredes finas foram notadas em todos e espessamento pleural subjacente às cavidades foi observado em dois pacientes. Todos foram tratados inicialmente com isoniazida, rifampicina, pirazinamida (INH-RMP-PZA e etambutol (EMB foi introduzido precocemente em dois pacientes por intolerância à pirazinamida, enquanto que em outros dois a introdução foi feita ao ser conhecido o resultado da cultura. Todos os pacientes foram tratados por mais de nove meses, tendo sido observada recidiva em um deles. Um paciente com silicose faleceu após dois anos por insuficiência respiratória, depois de ter sido considerado curado. CONCLUSÕES: A micobacteriose por M. kansasii foi encontrada com baixa freqüência, podendo estar relacionada às características dos pacientes encaminhados ao nosso serviço. O esquema INH-RMP-PZA, com substituição eventual da PZA por etambutol, mostrou sucesso terapêutico.BACKGROUND: Mycobacterium kansasii is a nontuberculous mycobacterium that can colonize the lungs and cause pulmonary infection. OBJECTIVE: To report authors' study of 6 patients with pulmonary disease caused by M. kansasii infection in

  5. FATORES DE RISCO EM PACIENTES COM INFECÇÕES HOSPITALARES CAUSADAS POR Klebsiella pneumoniae PRODUTORA DE CARBAPENEMASE

    OpenAIRE

    Fernanda Paula Franchini

    2016-01-01

    Klebsiella pneumoniae produtora de klebsiella pneumoniae carbapenemase (KPC-Kp) é um patógeno emergente, com resistência a várias classes de antibióticos, sendo que suas infecções são associadas a considerável mortalidade. Este estudo tem como objetivo identificar fatores de risco para aquisição de infecções hospitalares causadas por KPC-Kp e identificar o desfecho clínico dos pacientes que adquirem essas infecções. Este é um estudo de caso-controle realizado em um hospital-escola terciário d...

  6. Incidência de viroses e enfezamentos e estimativa de perdas causadas por molicutes em milho no Paraná

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    Oliveira Elizabeth de

    2003-01-01

    Full Text Available O objetivo deste trabalho foi avaliar a incidência de viroses e enfezamentos e estimar as perdas causadas por enfezamentos na cultura do milho safrinha. Os diagnósticos baseados em sintomas foram confirmados por PCR ou RTPCR. Em todas as lavouras, foram identificadas plantas com sintomas de enfezamentos, em incidência de 6,2% a 49,9% (média de 20,7%. Na identificação de insetos vetores desses patógenos, a cigarrinha Dalbulus maidis foi detectada em 20 lavouras das 24 amostradas, constituindo 66,6% do total de espécimens de cigarrinhas coletadas. A perda potencial causada pelos enfezamentos no período foi estimada em cerca de 16,5 milhões de dólares. A ocorrência de plantas com sintomas de "Maize rayado fino virus" e "Maize dwarf mosaic virus" foi baixa e o diagnóstico confirmado por RTPCR. A análise de 441 amostras suspeitas de infecção por "Mal de Río Cuarto virus", por DASELISA, mostrou ausência desse vírus. Resultados de PCR indicaram a presença de um possível fitoplasma distinto de "Maize bushy stunt phytoplasma" em duas plantas apresentando nanismo acentuado, folhas estreitas, enrijecidas, com deformações, e grãos na inflorescência, havendo necessidade de mais estudos para a confirmação da identidade desse possível novo fitoplasma.

  7. Salmonella causada por reptiles y anfibios en guarderías (Salmonella Infections Caused by Reptiles and Amphibians in Childcare Centers)

    Centers for Disease Control (CDC) Podcasts

    2013-02-07

    Traducción al español de la entrevista con el Dr. Neil Vora, funcionario del EIS de los CDC, sobre su artículo acerca de las infecciones por Salmonella causadas por reptiles y anfibios en guarderías.  Created: 2/7/2013 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 2/26/2013.

  8. Identificación de loci de resistencia cuantitativa para la podredumbre de la espiga de maíz causada por Fusarium moniliforme Sheldon y roya común causada por Puccinia sorghi en germoplasma argentino de maíz

    OpenAIRE

    Rey, J. I.; Lúquez, Julia

    2009-01-01

    La podredumbre de la espiga de maíz causada por Fusarium moniliforme Sheldon, y la roya común, causada por Puccinia sorghi, son dos de las más importantes enfermedades del maíz en Argentina. Se observa variabilidad para la resistencia a ambas enfermedades entre los grupos heteróticos Iowa Stiff Stalk y Flint Argentino, utilizados para el mejoramiento genético del maíz. Se ha informado sobre la existencia de resistencia general a podredumbre de la espiga para podredumbre y sobre resistencia ge...

  9. Proptose causada por adenoma pituitário gigante: relato de caso

    Directory of Open Access Journals (Sweden)

    Pereira Andréa

    2003-01-01

    Full Text Available OBJETIVO: Relatar um caso raro de proptose unilateral associada à paralisia oculomotora e cegueira causados por adenoma pituitário gigante. MÉTODOS: A paciente foi submetida a exame clínico e oftalmológico completo, campimetria, exame de imagem por ressonância magnética e estudo histopatológico do tumor após intervenção cirúrgica. RESULTADOS: Paciente de 21 anos apresentou perda visual progressiva bilateral associada à proptose e limitação da motilidade ocular do olho esquerdo. A campimetria revelou hemianopsia temporal completa no olho direito e havia ausência de percepção luminosa no olho esquerdo. O exame de imagem por ressonância magnética mostrou extenso tumor infiltrando o terceiro ventrículo, seio cavernoso e ápice da órbita à esquerda. O estudo histopatológico revelou se tratar de adenoma hipofisário produtor de hormônio de crescimento e prolactina sem sinais de malignidade. CONCLUSÃO: Este caso é de interesse não apenas pelo fato do envolvimento orbitário pelos adenomas ser extremamente raro, mas também para salientar a importância de diagnóstico precoce uma vez que apesar da histologia benigna, os adenomas invasivos nem sempre seguem curso clínico favorável.

  10. Surdez súbita causada por hemorragia intralabiríntica Sudden hearing loss caused by labyrinthine hemorrhage

    Directory of Open Access Journals (Sweden)

    Raquel Salomone

    2008-10-01

    Full Text Available A surdez súbita sensorioneural é uma perda auditiva súbita ou rapidamente progressiva. Na maioria dos casos a etiologia não é descoberta. Uma das causas possíveis de surdez súbita é a hemorragia intralabiríntica que, antes do surgimento da ressonância magnética, não era corretamente diagnosticada. O objetivo deste trabalho é relatar um caso de surdez súbita causada por hemorragia intralabiríntica e realizar uma revisão da literatura sobre este assunto.Sudden sensorineural hearing loss is relatively frequent. In most cases, the etiology is not discovered. One of the possible causes for sudden deafness is inner labyrinth bleeding, which was difficult to diagnose before the advent of magnetic resonance imaging. The purpose of this paper is to report a case of sudden hearing loss caused by a labyrinthine hemorrhage, and to present a review of the literature on this topic.

  11. Pudrición basal causada por Phytophthora capcisi en plantas de chile tratadas con vermicompost

    Directory of Open Access Journals (Sweden)

    Lidieth Uribe-Lorío

    2014-07-01

    Full Text Available El objetivo de este trabajo fue evaluar a nivel de invernadero el efecto de vermicompost sobre la incidencia y severidad de Phytophthora capcisi en plantas de chile (Capsicum annuum. Esta investigación se realizó entre febrero y marzo del 2012 en el Centro de Investigaciones Agronómicas, Sabanilla, San José, Costa Rica. Se utilizó un diseño completamente al azar con cuatro repeticiones y ocho plantas por unidad experimental en un arreglo factorial con los factores de dosis (0, 25% y 50% v/v vermicompost:suelo e inoculación (0 y 500 zoosporas por gramo de suelo. Se trasplantaron plántulas de 35 días, que fueron inoculadas dos semanas después del trasplante. La aplicación de vermicompost provocó un aumento significativo del peso fresco foliar y del peso seco foliar y radical; a mayor dosis, mayor fue el incremento. Las plantas de todos los tratamientos que incluyeron inoculación con P. capsici presentaron síntomas de la enfermedad en la raíz. Los valores de incidencia y severidad fueron mayores para el tratamiento con 50% de abono. En este tratamiento se presentaron síntomas de marchitez. La ausencia de diferencias en las variables de peso fresco y seco entre los tratamientos inoculados y sin inocular, a los que se adicionó abono al 25%, sugiere que esta dosis podría compensar el daño causado por el patógeno. Se observó una menor concentración de nutrimentos en los tejidos de las plantas inoculadas lo que indica que el daño causado a la raíz pudo haber afectado la adquisición de nutrimentos.

  12. Agnosia integrativa causada por una epilepsia focal occipital izquierda: estudio de caso

    OpenAIRE

    Óscar Mauricio Aguilar Mejía; Beatriz Ramírez Bermejo; Luis Manuel Silva Martín

    2011-01-01

    La agnosia integrativa es un tipo de agnosia visual asociada a lesiones occipitales bilaterales que se caracteriza por la incapacidad para identificar estímulos en fondos complejos, especialmente, cuando se trata de formas superpuestas o entrelazadas. Existen dificultades para codificar y agrupar el todo a partir de las partes del estímulo. Se presenta un caso de una paciente de 14 años, con una agnosia integrativa como consecuencia de una epilepsia focal sintomática refractaria, con un foco ...

  13. Endocardite valvar mitral causada por Chlamydia psittaci: apresentação de um caso raro

    OpenAIRE

    Wolker,Rinaldo Luiz; Hahn,Cristiano Gustavo; Rita,Jorge Rafael Ruiz; Giublin, Paulo Roberto

    2006-01-01

    Relatamos o caso de um criador de pássaros que desenvolveu um quadro consuntivo, febril, com mialgia e hemoculturas negativas. Internado por três ocasiões, foi tratado empiricamente com antibióticos, sem melhora. Após quatro meses, apresentou piora com sinais de infecção sistêmica. Ecocardiograma demonstrou insuficiência mitral moderada, com vegetações, não presentes em exame prévio. Sorologia positiva para Chlamydia psittaci (imunofluorescência indireta). Na cirurgia, identificou-se grande d...

  14. Agnosia integrativa causada por una epilepsia focal occipital izquierda: estudio de caso

    Directory of Open Access Journals (Sweden)

    Óscar Mauricio Aguilar Mejía

    2011-01-01

    Full Text Available La agnosia integrativa es un tipo de agnosia visual asociada a lesiones occipitales bilaterales que se caracteriza por la incapacidad para identificar estímulos en fondos complejos, especialmente, cuando se trata de formas superpuestas o entrelazadas. Existen dificultades para codificar y agrupar el todo a partir de las partes del estímulo. Se presenta un caso de una paciente de 14 años, con una agnosia integrativa como consecuencia de una epilepsia focal sintomática refractaria, con un foco epileptogénico occipital izquierdo. Se plantean las características clínicas de la paciente y se hace un análisis de sus procesos de reconocimiento visual discutidos a partir de los diferentes modelos teóricos que tratan de explicar la percepción visual.

  15. ANTRACNOSE DO CAQUIZEIRO CAUSADA POR Colletotrichum horii: INCIDÊNCIA EM RAMOS, FOLHAS, FLORES E FRUTOS EM CAMPO

    Directory of Open Access Journals (Sweden)

    RENATO REZENDE YOUNG BLOOD

    2015-06-01

    Full Text Available O objetivo deste trabalho foi avaliar a incidência em várias partes da planta e o desenvolvimento da antracnose do caquizeiro causada por Colletotrichum horiinas cultivares Fuyu e Kakimel produzidas sob os sistemas orgânico e convencional, respectivamente, nas safras de 2010/2011 e 2011/2012, em Campina Grande do Sul, Paraná, Brasil. Em cada pomar, 10 plantas foram selecionadas aleatoriamente, e 10 ramos do ano por planta, distribuídos ao redor dacopa, foram marcados para as avaliações de incidência de antracnose em ramos e folhas, a cada 15 dias. A quantificação de frutos caídos com ou sem sintomas da doença foi a cada 15 dias, durante o período de crescimento de frutos até a colheita, relacionada com a produção total. C. horii em flores foi avaliada em campo e também após incubação no laboratório. Infecção latente foi observada em frutos verdes coletados aos 90; 120 e 150 dias após a floração. Em ambas as safras, observou-se a queda de frutos com sintomas de antracnose entre os meses de janeiro e abril. C. horii é capaz de infectar flores, permanecer latente e provocar sintomas de antracnose em frutos imaturos. Frutos colhidos sadios apresentaram sintomas em pós-colheita após a incubação.

  16. Comportamiento de la diarrea causada por virus y bacterias en regiones cercanas a la zona ecuatorial

    Directory of Open Access Journals (Sweden)

    María Fernanda Gutiérrez

    2005-12-01

    Full Text Available Introducción: La enfermedad diarreica aguda (EDA es un problema de salud a nivel mundial que afecta a la población infantil de distintas regiones. Casi todos los estudios epidemiológicos se han hecho en países con estaciones y poco se informa su comportamiento en países sin estaciones, donde la EDA es endémica con picos epidémicos. Objetivos: Contribuir a conocer la conducta de EDA en Colombia y determinar si su comportamiento es diferente en niños menores de cinco años en dos regiones distintas entre sí en geografía y clima. Materiales y métodos: Se hizo un estudio descriptivo en dos localidades colombianas. Una en la costa atlántica y otra en el centro del país. La muestra se obtuvo en menores de cinco años que consultaron por diarrea a centros asistenciales de cada región. Los microorganismos bacterianos se identificaron mediante pruebas bioquímicas y los virus con técnicas inmunoenzimáticas. En el análisis estadístico se siguieron un ensayo bivariado y pruebas Z de normalidad para verificar si el clima modifica el comportamiento de EDA y si se presenta de manera distinta en las dos regiones. Resultados: En ambas zonas (Cartagena, Bolívar y Facatativa, Cundinamarca predominó la diarrea viral, frente a la EDA bacteriana. También en ambas el rotavirus fue prevalente. Fue mucho más baja la presencia de astrovirus y adenovirus. No hubo datos con significación estadística para demostrar que las condiciones ambientales y las propias de los niños, alteran el comportamiento de la EDA, pero sí se observó que la EDA por rotavirus se comporta de manera diferente al analizar en forma comparativa las dos regiones del estudio.

  17. Comportamiento de la diarrea causada por virus y bacterias en regiones cercanas a la zona ecuatorial.

    Directory of Open Access Journals (Sweden)

    María Fernanda Gutiérrez

    2009-11-01

    Full Text Available INTRODUCCIÓN: La enfermedad diarreica aguda (EDA es un problema de salud a nivel mundial que afecta a la población infantil de distintas regiones. Casi todos los estudios epidemiológicos se han hecho en países con estaciones y poco se informa su comportamiento en países sin estaciones, donde la EDA es endémica con picos epidémicos. OBJETIVOS: Contribuir a conocer la conducta de EDA en Colombia y determinar si su comportamiento es diferente en niños menores de cinco años en dos regiones distintas entre sí en geografía y clima. MATERIALES Y MÉTODOS: Se hizo un estudio descriptivo en dos localidades colombianas. Una en la costa atlántica y otra en el centro del país. La muestra se obtuvo en menores de cinco años que consultaron por diarrea a centros asistenciales de cada región. Los microorganismos bacterianos se identificaron mediante pruebas bioquímicas y los virus con técnicas inmunoenzimáticas. En el análisis estadístico se siguieron un ensayo bivariado y pruebas Z de normalidad para verificar si el clima modifica el comportamiento de EDA y si se presenta de manera distinta en las dos regiones. RESULTADOS: En ambas zonas (Cartagena, Bolívar y Facatativa, Cundinamarca predominó la diarrea viral, frente a la EDA bacteriana. También en ambas el rotavirus fue prevalente. Fue mucho más baja la presencia de astrovirus y adenovirus. No hubo datos con significación estadística para demostrar que las condiciones ambientales y las propias de los niños, alteran el comportamiento de la EDA, pero sí se observó que la EDA por rotavirus se comporta de manera diferente al analizar en forma comparativa las dos regiones del estudio.

  18. Paraplegia aguda por compressão da medula espinhal torácica causada por tofo gotoso

    OpenAIRE

    2007-01-01

    O acometimento axial pela gota é um evento raro, e o envolvimento da coluna torácica foi descrito em apenas 17 casos na literatura. Apresentamos um caso de paciente do sexo masculino de 48 anos com história de gota, sob tratamento irregular com alopurinol e colchicina, que desenvolveu paraplegia aguda decorrente de compressão medular por tofo gotoso. Realizou-se o diagnóstico por meio de ressonância magnética e anatomia patológica. Foi tratado com antiinflamatórios e descompressão cirúrgica c...

  19. Piomiositis primaria causada por Streptococcus intermedius Primary pyomyositis caused by Streptococcus intermedius

    Directory of Open Access Journals (Sweden)

    F. J. Repáraz

    2007-08-01

    Full Text Available La piomiositis es una infección subaguda bacteriana que afecta al músculo estriado y suele acompañarse de la formación de un absceso en dicho músculo. Fue descrita inicialmente como una enfermedad endémica en los trópicos y sólo en los últimos años se ha observado un incremento del número de casos en países de clima templado en relación a un aumento de pacientes inmunodeprimidos. El germen causal es Staphylococcus aureus en más del 75% de los casos. La prueba de imagen más útil es la resonancia magnética. El tratamiento consiste en el drenaje quirúrgico completo del absceso combinado con una antibioterapia adecuada. Presentamos un caso de piomiositis primaria del cuádriceps en un paciente diabético con un antecedente traumático remoto de la zona afectada y causado por un germen inusual. Se obtuvo una recuperación completa y sin secuelas tras drenaje quirúrgico y 4 semanas de tratamiento antibiótico endovenoso.Pyomyositis is a sub-acute bacterial infection that affects the striated muscle and is usually accompanied by the formation of an abscess in this muscle. It was initially described as an endemic disease in the tropics and only in recent years has an increase been observed in the number of cases in countries with a temperate climate in relation to an increase of immuno-depressed patients. The causal germ is Staphylococcus aureus in more than 75% of cases. The most useful imaging test is magnetic resonance. Treatment consists of complete surgical draining of the abscess combined with a suitable antibiotic therapy. We present a case of primary pyomyositis of the quadriceps in a diabetic patient with a remote traumatic antecedent of the affected zone and caused by an unusual germ. A complete recovery was obtained, without sequels, following surgical draining and 4 weeks of endovenous antibiotic treatment.

  20. Prevalência da filariose canina causada por Dirofilaria immitis e Dipetalonema reconditum em Maceió, Alagoas, Brasil

    Directory of Open Access Journals (Sweden)

    Brito Ana Cristina

    2001-01-01

    Full Text Available A prevalência da filariose canina causada por Dirofilaria immitis e Dipetalonema reconditum, foi estimada após a realização de inquérito hemoscópico em 1.519 cães domiciliados. Foram examinados 1.097 cães nos sete distritos sanitários da cidade de Maceió, Alagoas, 204 na Ilha de Santa Rita e 218 na cidade de Paripueira. Em Maceió, foram detectados 15 (1,3% cães com microfilárias (MF de D. immitis e 15 (1,3% com MF de D. reconditum. Todos os casos positivos foram considerados autóctones. As MF de D. immitis e de D. reconditum mediram 298,1µm e 249,2µm de comprimento e 7,3µm e 4,4µm de largura, respectivamente. Além do diagnóstico parasitológico pela técnica de gota espessa (100µL, foi utilizado o teste imunológico Witness, para detecção de antígeno filarial circulante, o qual confirmou os dados parasitológicos e permitiu a detecção de casos de infecção oculta. De um total de 6.579 fêmeas examinadas, pertencentes a seis espécies de mosquitos, oito (0,1% fêmeas de Culex quinquefasciatus foram encontradas naturalmente infectadas com larvas de D. immitis. Estes resultados demonstram a presença simultânea de D. immitis e D. reconditum na mesma área geográfica.

  1. Indicadores de riesgo de morbilidad prevenible causada por medicamentos Risk indicators of preventable morbidity related to drug utilization

    Directory of Open Access Journals (Sweden)

    Ana Dago Martínez

    2007-02-01

    Full Text Available Objetivos: Seleccionar y estudiar la aceptabilidad, en términos de relevancia y pertinencia, de ciertas situaciones clínicas que puedan usarse como indicadores de riesgo de morbilidad prevenible causada por medicamentos y que sean utilizables en las farmacias comunitarias. Método: Método Delphi, en 2 rondas, con un panel de 14 expertos médicos y farmacéuticos que valoraron la relevancia y pertinencia de 68 tipos de situaciones clínicas como indicadores de morbilidad potencial relacionada con medicamentos, detectable por el profesional en su medio, con evidencia científica de resultado adverso previsible, frecuentes en el medio ambulatorio y con causa y resultado controlables. Resultados: Se consideraron utilizables y pertinentes 43 de los 68 indicadores estudiados, que se referían a 3 ámbitos: tipo de medicamento (medicamentos de estrecho margen terapéutico, con dosis individualizada y con reacciones adversas frecuentes y graves, problema de salud (problemas crónicos, especialmente asma, enfermedad cardíaca, tiroidea, prostática y dolor y tipo de paciente (ancianos y/o polimedicados. Los farmacéuticos sobrevaloraron sistemáticamente ciertos indicadores en relación con los médicos, aunque las diferencias no fueron significativas. Conclusiones: Se identificaron 43 indicadores de morbilidad potencial relacionada con los medicamentos e identificables por los profesionales en su entorno.Objective: To select clinical situations that can be used as risk indicators of preventable morbidity caused by drugs at the community pharmacies, and to study their acceptability, in terms of pertinence and relevance. Methods: We used the Delphi technique, in 2 rounds, by a panel of 14 medical doctors and pharmacists experts, to study the relevance of 68 types of clinical situations as risk indicators of preventable morbidity related to drug utilization used by health professionals in community pharmacies, with scientific evidence of foreseeable

  2. Hipertensão pseudo-resistente causada por baixa adesão terapêutica

    Directory of Open Access Journals (Sweden)

    Alfredo Dias Oliveira-Filho

    2015-09-01

    Full Text Available Este estudo teve como objetivo identificar pacientes com hipertensão arterial pseudo-resistente causada pela não-adesão terapêutica. Foi realizado um estudo transversal com pacientes com hipertensão atendidos pela Estratégia de Saúde da Família. As entrevistas e medidas da pressão arterial ocorreram nas residências dos pacientes cadastrados em uma unidade de saúde da família, em Maceió, entre abril de 2011 e fevereiro de 2012. Os pacientes com pressão arterial não-controlada foram classificados como pacientes com hipertensão arterial resistente (HAR ou com hipertensão pseudo-resistente, definida como a observação de falha no controle da PA causada por farmacoterapia anti-hipertensiva inapropriada, não adesão aos anti-hipertensivos, medida inadequada da PA ou efeito do jaleco branco. A adesão terapêutica foi determinada por meio da Escala de Adesão Terapêutica de oito itens de Morisky (MMAS-8. Foram investigados 173 pacientes, com idade média de 55 anos (DP 11,08 e predominância do sexo feminino (71,0%. Observou-se que 63,0% dos pacientes apresentaram PA não-controlada, dentre estes, 87,2% não eram aderentes à farmacoterapia anti-hipertensiva. Apenas 4 (2,3% pacientes foram identificados com HAR. No total, 95 pacientes não-aderentes (54,9% poderiam ser diagnosticados erroneamente como portadores de HAR, caracterizando a hipertensão pseudo-resistente causada por não-adesão. Observou-se que a não-adesão à farmacoterapia anti-hipertensiva parece ser uma relevante – e potencialmente a principal – causa da hipertensão pseudo-resistente. A identificação e remoção de tal causa podem contribuir significativamente para o diagnóstico da hipertensão resistente, evitando superexposição a medicamentos desnecessários e terapias adicionais excessivas.Palavras-chave: Pressão arterial. Hipertensão resistente. Adesão à medicação. Hipertensão pseudo-resistente. ABSTRACTMedication adherence in patients with

  3. Análise da ação do gel de plaquetas e glutamina em mucosite causada por quimioterapia induzida em ratos Wistar

    OpenAIRE

    Regina Haddad Barrach Zabalia

    2015-01-01

    Neste estudo avaliou-se a ação do gel de Plaquetas e da Glutamina no processo de cicatrização de lesões bucais causadas por mucosite induzida por quimioterapia em ratos Wistar. Foram utilizados 50 animais divididos em 05 grupos: um Grupo A (Gel de Plaquetas), Grupo B (Glutamina tópica), Grupo C (Glutamina gavagem), Grupo D (Glutamina + Gel de plaquetas) e Grupo E (controle +). A partir do 7o dia após a quimioterapia, avaliou-se os graus de mucosite e iniciou-se a aplicação dos medicamentos pr...

  4. Jejunal perforation caused by abdominal angiostrongyliasis Perfuração jejunal causada por angiostrongilíase abdominal

    Directory of Open Access Journals (Sweden)

    Jaques WAISBERG

    1999-09-01

    Full Text Available The authors describe a case of abdominal angiostrongyliasis in an adult patient presenting acute abdominal pain caused by jejunal perforation. The case was unusual, as this affliction habitually involves the terminal ileum, appendix, cecum or ascending colon. The disease is caused by the nematode Angiostrongylus costaricensis, whose definitive hosts are forest rodents while snails and slugs are its intermediate hosts. Infection in humans is accidental and occurs via the ingestion of snail or slug mucoid secretions found on vegetables, or by direct contact with the mucus. Abdominal angiostrongyliasis is clinically characterized by prolonged fever, anorexia, abdominal pain in the right-lower quadrant, and peripheral blood eosinophilia. Although usually of a benign nature, its course may evolve to more complicated forms such as intestinal obstruction or perforation likely to require a surgical approach. Currently, no efficient medication for the treatment of abdominal angiostrongyliasis is known to be available. In this study, the authors provide a review on the subject, considering its etiopathogeny, clinical picture, diagnosis and treatment.Os autores descrevem caso de angiostrongilíase abdominal em doente adulto que se manifestou como abdômen agudo devido à perfuração de alça jejunal, evento raro, uma vez que esta afecção geralmente envolve o íleo terminal, apêndice, ceco ou cólon ascendente. A doença é causada pelo nematódeo Angiostrongylus costaricensis cujos hospedeiros definitivos são roedores silvestres e os hospedeiros intermediários são caracóis e caramujos. A infecção em humanos é acidental e ocorre pela ingestão de secreção mucóide destes invertebrados presentes em vegetais ou por contato direto com o muco. A angiostrongilíase abdominal é clinicamente caracterizada pela presença de febre prolongada, anorexia, dor no quadrante inferior direito do abdômen e eosinofilia periférica. Embora a doença seja de

  5. Costo económico de la discapacidad causada por lesiones de tránsito en México durante 2012

    OpenAIRE

    Patricia G. Sánchez-Vallejo; Ricardo Pérez-Núñez; Ileana Heredia-Pi

    2015-01-01

    Para estimar el costo económico de la discapacidad permanente causada por lesiones de tránsito en México durante 2012, desde las perspectivas del Sistema de Salud y de la Sociedad, se realizó un estudio de costos que utiliza metodología bottom-up, considerando costos directos médicos (hospitalización, consultas ambulatorias y de rehabilitación y prótesis), y costos indirectos (pérdida de productividad del lesionado y cuidador) con una aproxima...

  6. Dermatomicose e ceratite micótica causada por Exophiala sp em um cão Dermatomycosis and mycotic keratitis caused by Exophiala sp in a dog

    OpenAIRE

    2008-01-01

    Neste trabalho, descreve-se o diagnóstico e a conduta terapêutica aplicada em caso de dermatomicose e ceratite micótica causada por Exophiala sp em um cão com um ano e seis meses de idade. Os sinais clínicos incluíam alopecia, crostas, despigmentação e ulceração do plano nasal e focinho, e ceratite superficial bilateral no canto lateral dos olhos. Na cultura fúngica foi isolado Exophiala sp e o exame histopatológico da biopsia cutânea revelou dermatite nodular superficial e profunda granuloma...

  7. Diseño y estandarización de una prueba de PCR para el diagnóstico de la Bartonelosis causada por Bartonella bacilliformis

    Directory of Open Access Journals (Sweden)

    Carlos Padilla R

    2003-03-01

    Full Text Available Objetivo: Diseñar una prueba de PCR para el diagnóstico de la Bartonelosis causada por Bartonella bacilliformis. Materiales y métodos: Se usó la secuencia del locus de invasión ialB para diseñar los oligonucleótidos ialBF y ialBR, además del ADN geonómico purificado de una cepa referencial de B. bacilliformis para estandarizar las condiciones de la prueba. Finalmente, la prueba fue preliminarmente evaluada con 12 cepas de B. bacilliormis aisladas en 3 áreas endémicas y 10 muestras de sangre total de pacientes con Bartonelosis confirmada. Resultados: La prueba detectó el ADN de aislamientos de B. bacilliformis de 3 áreas bartonelósicas endémicas del Perú: Ancash, Cuzco y Lima; mientras que no detectó el ADN de B. hensenlae, ni de B. vinsonii, ni de otras bacterias y parásitos. Además, esta prueba fue positiva para 10 muestras sanguíneas de pacientes con bartonelosis confirmada y negativa para 5 muestras de pacientes con malaria por P. falciparum. Conclusión: Esta prueba de PCR podría ser útil para el diagnóstico de la bartonelosis causada por B. bacilliformis.

  8. An unusual gangrenous goat mastitis caused by Staphylococcus aureus, Clostridium perfringens and Escherichia coli co-infection Mastite gangrenosa caprina atípica causada por co-infecção por Staphylococcus aureus, Clostridium perfringens e Escherichia coli

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    M.G. Ribeiro

    2007-06-01

    Full Text Available Relata-se, pela primeira vez no Brasil, a ocorrência de mastite gangrenosa caprina atípica causada pela co-infecção por Staphylococcus aureus, Clostridium perfringens e Escherichia coli em uma cabra da raça Boer, na segunda semana de lactação. Descrevem-se os achados clínicos, os procedimentos de diagnóstico microbiológico e a conduta terapêutica.

  9. Mastite bovina causada por Prototheca zopfii: relato de um caso Clinical bovine mastitis caused by Prototheca zopfii: a case study

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    Maria Aparecida Vasconcelos Paiva Brito

    1997-12-01

    Full Text Available Um caso de mastite clínica causada por Prototheca zopfii em uma vaca de um rebanho leiteiro localizado na Zona da Mata do Estado de Minas Gerais foi estudado. O animal apresentou sinais clínicos nos quartos mamárias anteriores e queda acentuada na produção de leite. Após o diagnóstico inicial, o animal foi observado durante onze meses, do início da manifestação da doença até 12 dias após o parto. Exames microbiológicos do leite foram realizadas aos 7, 30, 39, 49, 65, 326 e 331 dias após o isolamento inicial, sendo os dois últimos exames realizados 7 e 12 dias após o parto. As amostras de P. zopfii isoladas apresentaram resistência in vitro a: ampicilina, canamicina, cefatoridina, enrofloxacina, estreptomicina, gentamicina, neomicina, oxacilina, penicilina, sulfonamidas e trimetoprim x sulfametoxazol. Foi avaliada a susceptibilidade in vitro das amostras de P. zopfii a um produto natural constituído de extrato de sementes de frutas cítricas, obtido comercialmente. A menor concentração que inibiu totalmente a alga foi 1:500. Recomendou-se um tratamento com a diluição a 1:200 do extrato em solução fisiológica estéril contendo timerosal a 1:30.000 como conservante, em doses diárias de 20ml, por via intramamária. O tratamento foi realizado inicialmente durante sete dias. Após este período houve redução, mas não a completa eliminação dos organismos do leite. Foi, então, recomendado mais um período de 15 dias de tratamento, de modo semelhante ao primeiro. Trinta e nove dias após o diagnóstico inicial não foi mais isolado P. zopfii do leite dos quartos afetados e a produção retornou a níveis semelhantes de antes da infecção. Amostras de leite naturalmente infectadas foram congelados a -20°C. Células viáveis de P. zopfii foram recuperadas de amostras mantidas até 38 dias nestas condições.A clinical case of mastitis caused by Prototheca zopfii in a cow from a dairy herd located in the region of Zona da

  10. Tasa de infección de la pudrición del tallo en maíz causada por Fusarium moniliforme

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    Mariano Mendoza Elos; Enrique Andrio Enr\\u00EDquez; Alfonso L\\u00F3pez Ben\\u00EDtez; Ra\\u00FAl Rodr\\u00EDguez Guerra; Luis Latournerie Moreno; Sergio A. Rodr\\u00EDguez Herrera

    2006-01-01

    Tasa de infección de la pudrición del tallo en maíz causada por Fusarium moniliforme. El objetivo de éste trabajo fue determinar la resistencia horizontal de 134 líneas S1 de maíz al hongo Fusarium moniliforme. La enfermedad fue inducida mediante inoculación en la etapa de floración masculina bajo condiciones de campo utilizando la técnica del palillo. Las líneas se evaluaron en México en 2002. La estimación de la enfermedad se hizo en dos ocasiones con una separación de 20 días. Las evaluaci...

  11. Podridão de raízes causada por Pythium aphanidermatum, em cultivares de alface produzidas em sistema hidropônico

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    Zayame Vegette Pinto

    2011-12-01

    Full Text Available A podridão de raízes, causada por Pythium aphanidermatum e outras espécies de Pythium, é a principal doença da alface cultivada em sistemas hidropônicos no Brasil. O presente trabalho teve como objetivo avaliar quatro cultivares comerciais de alface em relação à sensibilidade a podridão de raízes, causada por P. aphanidermatum. Os estudos foram realizados em placas de Petri contendo ágar-água com plântulas de alface das cultivares crespa (Vera e Verônica e lisa (Regina e Elisa, infestadas ou não com o patógeno. Com as mesmas cultivares foram realizados quatro experimentos em sistemas hidropônicos (Nutrient Film Technique, sendo dois em estufa coberta com plástico e sombrite e dois em estufa coberta apenas com plástico. As plântulas, infectadas ou não com P. aphanidermatum, foram transplantadas para os sistemas infestados ou não. Foi avaliada a severidade da doença e o desenvolvimento das plantas. Todas as cultivares foram suscetíveis à podridão de raízes nos experimentos realizados in vitro e in vivo. A presença do sombrite não reduziu a podridão de raízes em cultivares de alface produzidas no sistema hidropônico. A cultivar Regina apresentou maior massa de matéria seca da parte aérea e das raízes, na presença ou ausência do patógeno, sendo a mais indicada para o cultivo hidropônico na época mais quente do ano.

  12. Crestamento foliar, nova sintomatologia em algodoeiro causada por Xanthomonas axonopodis pv. malvacearum Cotton leaf blight, a new symptomatology caused by Xanthomonas axonopodis pv. malvacearum

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    Valdemar Atílio Malavolta Jr.

    2008-06-01

    Full Text Available Foi observada recentemente no Estado de São Paulo uma nova sintomatologia em algodoeiro cv. Makina, IAC 24 e Detaopal, causada por Xanthomonas axonopodis pv. malvacearum (Xam, denominada "crestamento foliar". Caracteriza-se por crestamento foliar, geralmente acompanhado por halo clorótico, podendo também causar sintomas de "V" invertido, a partir dos bordos foliares. Linhagens de Xam foram comparadas, por meio de testes de patogenicidade, bioquímicos, sorológicos, culturais e PCR-RFLP da região espaçadora 16S-23S DNAr. Independentemente do tipo de sintoma, as linhagens apresentaram características e perfis idênticos aos apresentados pela linhagem tipo, confirmando a identidade dos isolados como Xanthomonas axonopodis pv. malvacearum.Recently a new symptomatology on cotton plants (cv. Makina, IAC 24 and Deltaopal caused by Xanthomonas axonopodis pv. malvacearum (Xam was observed in São Paulo state, Brazil, and named "bacterial leaf blight". The symptom was characterized by leaf blight, generally exhibiting chlorotic haloes and sometimes showing V-shaped lesions beginning at the leaves' border. Strains of Xam responsible for typical angular leaf spots and bacterial leaf blight were compared through pathological, biochemical, serological, cultural and RFLP-PCR tests of the 16S-23S spacer region. Independently of the symptom type, the strains exhibited characteristics and profiles that were identical to those exhibited by the type strain, which confirms the isolates identity Xanthomonas axonopodis pv. malvacearum

  13. Síndrome hemolítico-urêmica causada por gencitabina em uma paciente jovem com colangiocarcinoma

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    John Fredy Nieto-Ríos

    2016-06-01

    Full Text Available Resumo A gencitabina é um fármaco utilizado no tratamento de vários tipos de neoplasias malignas. Há poucas descrições de associação entre a droga e a síndrome hemolítico-urêmica (SHU, apesar de os pacientes em questão terem ido a óbito em pelo menos 50% dos casos. O presente artigo relata o caso de uma paciente com 25 anos de idade em remissão diagnosticada com colangiocarcinoma que apresentou anemia hemolítica microangiopática acompanhada de insuficiência renal aguda anúrica após cinco ciclos de quimioterapia com gencitabina; as manifestações eram condizentes com SHU causada pelos efeitos colaterais do medicamento. A administração de gencitabina foi interrompida, e a paciente foi tratada com hemodiálise, transfusões de sangue, trocas de plasma, corticosteroides, doxiciclina e rituximabe. Foi atingido um desfecho favorável; mais especificamente, a hemólise foi controlada e a função renal foi plenamente restabelecida.

  14. Primeira ocorrência de ferrugem em capim-limão causada por Puccinia cymbopogonis no Brasil First report of the lemongrass rust fungi caused by Puccinia cymbopogonis in Brazil

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    João Batista Vida

    2006-03-01

    Full Text Available È registrada a primeira ocorrência de ferrugem em capim-limão (Cymbopogon citratus (DC. Stapf, causada por Puccinia cymbopogonis Mass., no Brasil, Estado do Paraná.It is reported the first occurrence of the lemongrass (Cymbopogon citratus (DC. Stapf rust fungi caused by Puccinia cymbopogonis Mass. in Brazil, State of Paraná.

  15. PÉRDIDAS CAUSADAS POR EL AMACHAMIENTO DEL FRIJOL (Aphelenchoides besseyi Christie Y REACCIÓN DEL GERMOPLASMA COMERCIAL AL PATÓGENO

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    N\\u00E9stor Felipe Chaves-Barrantes

    2012-01-01

    Full Text Available La determinación de pérdidas causadas por amachamiento (Aphelenchoides besseyi en campo se llevó a cabo entre 2007 y 2008, en las regiones Brunca y Huetar Norte de Costa Rica, y la prueba de reacción de variedades se realizó en 2009 en la región Brunca. Para determinar pérdidas se establecieron 83 microparcelas de 3 m a lo largo de la hilera del cultivo, en campos reproductores de semilla de la variedad Cabécar, donde se evaluó la incidencia de la enfermedad durante tres etapas fenológicas (V3 o V4, R6 y R8. Se cuantifi caron los principales indicadores de rendimiento para cada microparcela y, mediante un análisis de regresión y correlación, se estimaron las pérdidas causadas por el amachamiento. Para determinar la reacción de cultivares a la enfermedad, se expuso bajo presión de inóculo natural, diez plantas de cada variedad (Bribrí, Chánguena, Cabécar, Gibre, Chirripó, Guaymí y Brunca, y se comparó su producción de vainas con respecto a la misma cantidad de plantas sanas, por medio de una prueba de t para muestras independientes. Las pérdidas determinadas en condiciones de campo fueron del 71 al 80% en el número de vainas y del 70 al 85% en rendimiento. La reducción en el número de semillas por vaina (0-16% y en el peso de 100 semillas (0-19% fueron bajos. Ninguna de las variedades comerciales de frijol presentó resistencia al amachamiento, ya que se obtuvieron pérdidas superiores al 91% en el número de vainas en los cultivares evaluados, excepto Gibre (82%.

  16. Tuberculous uveitis

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    Oluleye TS

    2013-01-01

    Tunji Sunday OluleyeRetina and Vitreous Unit, Department of Ophthalmology, University College Hospital, Ibadan, NigeriaAbstract: Tuberculous uveitis is an underdiagnosed form of uveitis. Absence of pulmonary signs and symptoms does not rule out the disease. In an era of reduced immunity from human immunodeficiency virus and acquired immunodeficiency syndrome, the disease is becoming more prevalent. This review discusses the common manifestations of tuberculous uveitis, pointing out helpful di...

  17. Conidiobolomicose causada por Conidiobolus lamprauges em ovinos no Estado de Santa Catarina Conidiobolomycosis caused by Conidiobolus lamprauges in sheep in the state of Santa Catarina, Brazil

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    Fernando Henrique Furlan

    2010-07-01

    Full Text Available Descreve-se um surto de conidiobolomicose em ovinos no Estado de Santa Catarina. O surto ocorreu entre os meses de dezembro e março de 2006, no município de Santo Amaro da Imperatriz, região litorânea do Estado. A propriedade possuía 75 ovinos da raça Santa Inês e seis desses animais adoeceram. Clinicamente os animais doentes apresentavam dificuldade respiratória, corrimento nasal seroso a mucossanguinolento e, por vezes exolftalmia. Na necropsia verificou-se uma massa amarelada na região etmoidal e adjacências que, às vezes, atingia os linfonodos regionais, cérebro, globo ocular e pleura. Microscopicamente a massa caracterizava-se por infiltrado inflamatório granulomatoso com áreas necróticas associadas a hifas largas pouco ramificadas. Através de exame molecular detectou-se DNA de Conidiobolus lamprauges. Os aspectos clínicos, epidemiológicos, macroscópicos, microscópicos e moleculares caracterizam a conidiobolomicose causada por Conidiobolus lamprauges em ovinos.An outbreak of conidiobolomycosis affecting sheep in the State of Santa Catarina, Southern Brazil is reported. The disease occurred in six Santa Inês breed sheep from a flock of 75 during the rainy season. Common clinical signs were noisy respiration and dyspnea, serous to mucosanguineous nasal discharge and exophthalmus. At necropsy there was a dense yellow mass in the nasopharyngeal area affecting the ethmoidal region, turbinate bones and occasionally limph nodes, central nervous system and pleura. Histopathologycally there was multifocal granulomas whith an eosinophilic necrotic reaction containing ribbon type hyphae similar to zygomycetous fungi. At molecular examination Conidiobolus lamprauges DNA was detected. The clinical, epidemiological, macroscopical, microscopical and molecular aspects characterize conidiobolomycosis caused by Conidiobolus lamprauges in sheep.

  18. El estado de las lesiones causadas por el tránsito en México: evidencias para fortalecer la estrategia mexicana de seguridad vial

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    Ricardo Pérez-Núñez

    2014-05-01

    Full Text Available Mediante la revisión de información secundaria oficial, publicaciones científicas y el análisis de la ENSANut-2012, este trabajo busca proveer una visión integral de la magnitud actual de las lesiones causadas por el tránsito (LCT en México y analizar críticamente la respuesta social organizada. Las altas tasas de choques, lesiones, muertes y discapacidad atribuidas a este problema de salud pública, representan un elevado costo para la sociedad mexicana, en especial para los hogares. Se discute cómo la respuesta mexicana se ha enfocado a los automovilistas, dejando fuera a usuarios vulnerables de la vía pública y se ha privilegiado la implementación de estrategias poco efectivas. A pesar de que se dispone de legislación para los principales factores de riesgo, se ha descuidado su correcta aplicación. La estrategia mexicana podría fortalecerse implementando estrategias de movilidad seguras, equitativas, saludables y sostenibles para los diferentes actores de la vía pública. A pesar de los avances que se han dado en términos de prevención de LCT, existen aún retos y oportunidades para el país.

  19. Cura espontânea da leishmaniose causada por Leishmania Viannia Braziliensis em lesões cutâneas

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    Jackson Maurício Lopes Costa

    1990-12-01

    Full Text Available Os autores relatam que durante 14 anos de trabalho clínico em campo, realizado nas comunidades de Três Braços e Corte de Pedra, Bahia, acompanharam 1.416 pacientes portadores de Leishmaniose Tegumentar Americana, cuja espécie envolvida na transmissão, é predominantemente a Leishmania Viannia brasilienses. A terapêutica utilizada rotineiramente nos casos é o antimoniato-N-metilglucamina (Glucantime. Contudo, 16 pacientes do sexo masculino recusaram-se a utilizar a medicação e 6 do sexo feminino encontravam-se em período gestacional, portanto não utilizaram o medicamento. Estes pacientes foram acompanhados por um período entre 4 a 12 anos, a partir do diagnóstico. Observou-se que em 9 pacientes (40,9% desta casuística, o tempo de cicatrizaçâo após o aparecimento da lesão, pode ser calculado em 6 meses de evolução. Quando se eleva a observação para 12 meses, temos que 19 pacientes (86,3% cicatrizaram suas lesões neste período. Em 3 casos (13,6% as lesões permaneceram ativas por mais de 12 meses. Conclui-se que os determinantes da cicatrizaçâo natural das lesões produzidas por Leishmania Viannia Braziliensis permanecem desconhecidos, dificultando para nós entendermos e compararmos aos efeitos das drogas utilizadas no tratamento da leishmaniose tegumentar.

  20. Desórdenes y enfermedad psiquiátrica causada por el uso de alcohol en Colombia

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    Hernan G. Rincon-Hoyos

    2016-04-01

    Full Text Available Antecedentes: Una comprensión precisa de la co-ocurrencia y la comorbilidad de los trastornos por consumo de alcohol (AUD en Colombia es crucial para la salud pública.Objetivo: Se realizó un análisis secundario, utilizando una base de datos gubernamental de población 2003/2004 para determinar las asociaciones de vida entre los trastornos por consumo de alcohol y otros trastornos mentales y adictivos en personas de edades comprendidas entre 18 a 65 años de Colombia.Métodos: Varios análisis estadísticos se realizaron: pruebas de diferencia en la prevalencia de los trastornos mentales en función de si el individuo tenía un AUD; un análisis estratificado por sexo y análisis de regresión logística teniendo en cuenta las diferencias en las variables del estado de salud, demográficas, socioeconómicas, de comportamiento y de auto-reporte.Resultados: las personas con AUD fueron el 9% de la población, de los cuales 88% eran varones y en promedio tenían 37 años. Estas personas tenían trabajo y eran fumadores activos; y tenían menos probabilidad de estar en casa o ser jubilados. La población con AUD tenía mayores posibilidades de cumplir con los criterios de todos los trastornos, excepto el trastorno depresivo menor, el trastorno de estrés post-traumático, la dependencia a la nicotina, y el trastorno oposicional desafiante.Conclusión: Este estudio demuestra una alta prevalencia de trastornos mentales en la población adulta con trastornos por consumo de alcohol en Colombia. Los resultados destacan la importancia de la comorbilidad como un signo de gravedad de la enfermedad e impacto en la salud pública y apoyan la necesidad de formación de más profesionales y el desarrollo de intervenciones y servicios apropiados.

  1. Pérdidas Humanas y Económicas Causadas por el Vulcanismo en Costa Rica entre 1953 y 2005

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    Irene Aguilar

    2014-12-01

    Full Text Available Se presenta por primera vez una aproximación integrada de los efectos de las erupciones volcánicas en el periodo comprendido entre los años 1953 y el 2005. El detalle de los daños en (puentes, casas, ferrocarril, fábricas, las pérdidas económicas (agricultura, ganadería, suministro de agua potable, interrupción de las actividades, pérdidas de vidas humanas y las inversiones (donaciones, medidas paliativas, se presenta en los correspondientes cuadros, los que se centran en los desastres y efectos económicos, sin embargo los efectos sociológicos y psicológicos no fueron evaluados. Tres emergencias nacionales se han producido, una debido a la erupción del Irazú en 1963-1965, la otra con el Arenal en 1968 y la del volcán Poás en 1990. Pero también varias crisis volcánicas ocurrieron en otros volcanes como el Poás (1953-1955, 1989-1994, Rincón de la Vieja (1967,1991, 1995 y 1998 y de nuevo en Arenal (1975, 1988 y 2000, que produjo las pérdidas económicas debidas a la lluvia acida y/o lahares, otras personas murieron debido a depósitos de flujos piroclásticos. La actividad volcánica es la responsable de al menos 48,7 millones dólares en el último siglo, cantidad que será necesaria escalar en un futuro estudio. En el presente siglo, el daño por la lluvia ácida es de más de $200 mil. Por el momento, se tiene certeza que 103 personas fueron muertas por la actividad volcánica en el siglo XX; no hay informes adicionales de muertes o personas heridas desde 1700. Este documento es la base para un trabajo futuro más centrado en la evaluación socioeconómica, el análisis del riesgo y su proyección hacia el futuro. Si una nueva erupción similar a la del Irazú en 1963-1965 o del Arenal en 1968, sucediera durante el presente siglo, las pérdidas económicas serán significativamente mayores que las anteriores.

  2. Dermatomicose e ceratite micótica causada por Exophiala sp em um cão Dermatomycosis and mycotic keratitis caused by Exophiala sp in a dog

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    Paula Cristina Basso

    2008-10-01

    Full Text Available Neste trabalho, descreve-se o diagnóstico e a conduta terapêutica aplicada em caso de dermatomicose e ceratite micótica causada por Exophiala sp em um cão com um ano e seis meses de idade. Os sinais clínicos incluíam alopecia, crostas, despigmentação e ulceração do plano nasal e focinho, e ceratite superficial bilateral no canto lateral dos olhos. Na cultura fúngica foi isolado Exophiala sp e o exame histopatológico da biopsia cutânea revelou dermatite nodular superficial e profunda granulomatosa. O tratamento com itraconazol sistêmico promoveu remissão dos sinais clínicos. Conclui-se que a realização de cultura fúngica e biópsia de pele são exames complementares eficazes no diagnóstico de dermatomicoses e que o emprego de itraconazol sistêmico pode ser efetivo no tratamento de dermatite fúngica e ceratite micótica causado por Exophiala sp em cão.This report describes the diagnosis and the therapeutic conduct applied to the cases of subcutaneous dermatomycosis and mycotic keratitis caused by Exophiala sp in a one and a half year-old dog. The clinical signs included alopecia, crusts, dispigmentation, ulcerations in the nose and superficial bilateral keratitis in the corner of the eyes. In the fungal cultures, Exophiala sp was isolated and the microscopic analysis revealed characteristics of fungal dermatitis. Systemic therapy with itraconazole evidenced remission of clinical signs. The realization of fungal cultures and cutaneous biopsy are efficient complementary procedures in the diagnosis of dermatomycosis and that the usage of oral itraconazole can be effective in the treatment of fungal dermatitis and mycotic keratitis caused by Exophiala sp in dogs.

  3. Cura espontânea da leishmaniose causada por Leishmania Viannia Braziliensis em lesões cutâneas

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    Jackson Maurício Lopes Costa

    1990-12-01

    Full Text Available Os autores relatam que durante 14 anos de trabalho clínico em campo, realizado nas comunidades de Três Braços e Corte de Pedra, Bahia, acompanharam 1.416 pacientes portadores de Leishmaniose Tegumentar Americana, cuja espécie envolvida na transmissão, é predominantemente a Leishmania Viannia brasilienses. A terapêutica utilizada rotineiramente nos casos é o antimoniato-N-metilglucamina (Glucantime. Contudo, 16 pacientes do sexo masculino recusaram-se a utilizar a medicação e 6 do sexo feminino encontravam-se em período gestacional, portanto não utilizaram o medicamento. Estes pacientes foram acompanhados por um período entre 4 a 12 anos, a partir do diagnóstico. Observou-se que em 9 pacientes (40,9% desta casuística, o tempo de cicatrizaçâo após o aparecimento da lesão, pode ser calculado em 6 meses de evolução. Quando se eleva a observação para 12 meses, temos que 19 pacientes (86,3% cicatrizaram suas lesões neste período. Em 3 casos (13,6% as lesões permaneceram ativas por mais de 12 meses. Conclui-se que os determinantes da cicatrizaçâo natural das lesões produzidas por Leishmania Viannia Braziliensis permanecem desconhecidos, dificultando para nós entendermos e compararmos aos efeitos das drogas utilizadas no tratamento da leishmaniose tegumentar.In field clinics in the comunities of Três Braços and Corte de Pedra, Bahia, we have attended 1.416 patients with tegumentary leishmaniasis in fourteen years, the predomi nant species in transmission is Leishmania Viannia brasiliensis (LVB. Because of the danger of metastasis with this infection treatment was routinely recomended with Glucantime. However sixteen patients refused injection therapy and six women were pregnant when seen and not treated. All patients were followed up in our clinic. All these patients closed their skin ulcers although one subsequently relapsed. Patients were followed up for variable periods (four to twelve years, after the diagnosis. In

  4. Ulceração de anastomose esôfago-entérica causada por alendronato

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    DUQUES Pedro

    2001-01-01

    Full Text Available Introdução - O alendronato de sódio, um aminobifosfonado indicado para o tratamento da osteoporose em mulheres pós-menopausadas, tem sido associado em vários relatos à esofagite. Estenose esofágica e sintomas gastrointestinais como dispepsia, náuseas, vômitos e dor abdominal também podem estar presentes. Objetivo - Relato do caso de paciente submetida a gastrectomia total com anastomose em Y de Roux devido a carcinóide gástrico que desenvolveu ulceração em anastomose esôfago-entérica após tratamento com esta droga. Material e Método - Paciente de 63 anos de idade, sexo feminino, iniciou terapia com alendronato na dose diária de 10 mg pela manhã, vindo a apresentar sintomas disfágicos e dor abdominal um mês após. Submetida a exame endoscópico, demonstrou-se ulceração no esôfago, na mucosa da anastomose esôfago-entérica e estenose esofágica. O tratamento medicamentoso foi descontinuado, tendo o sintoma de dor abdominal desaparecido e a disfagia diminuído de intensidade. Resultados - Houve remissão das lesões ulceradas, entretanto a estenose esofágica permaneceu. A paciente subseqüentemente foi tratada por dilatação endoscópica, evoluindo com melhora clínica e estando atualmente livre de sintomas. Conclusão - O alendronato de sódio tanto pode causar lesões na porção inferior do esôfago, como em segmentos mais distais do tubo digestivo nos pacientes cujo trânsito gastrointestinal é acelerado. Especial atenção deve ser dada aos pacientes gastrectomizados que fazem uso desta droga, pela possibilidade do desenvolvimento de lesões na mucosa entérica anastomosada e do surgimento de complicações temíveis como a estenose.

  5. Invaginación de intestino delgado en el adulto causada por lipoma submucoso de íleon

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    J. Arredondo

    2015-08-01

    Full Text Available Se presenta el caso de un paciente de 68 años con invaginación intestinal secundaria a un lipoma submucoso de íleon. Se trata de una entidad rara en adultos y que suele ser debida a una lesión orgánica. La manifestación clínica se caracteriza por vómitos, dolor abdominal y melenas. Se presenta el caso de un paciente al que tras la realización de una colonoscopia y un TAC abdominal, se realizó una resección ampliada de ciego e íleon terminal. En la actualidad la precisión del diagnóstico etiológico de las invaginaciones ha aumentado gracias al desarrollo de las pruebas de imagen, como el TAC. Se recomienda un tratamiento quirúrgico precoz, sin desinvaginación intraoperatoria dado el elevado riesgo de presentar una lesión maligna o isquémica en el adulto.

  6. Síndrome do canal de Guyon causada por cisto sinovial Guyon's canal syndrome due to a synovial cyst

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    Evandro Silva Ruas

    2010-01-01

    Full Text Available Apresentamos um caso de síndrome do canal de Guyon por um cisto sinovial no punho esquerdo de uma paciente do sexo feminino, de 48 anos. A paciente apresentava dor e parestesia na topografia do nervo ulnar, diminuição da força muscular e deformidade na mão esquerda. A eletroneuromiografia evidenciava compressão do nervo ulnar no nível do punho. Realizada a ressecção do cisto e descompressão do nervo no canal de Guyon. Após a cirurgia a paciente apresentou melhora da dor e da parestesia, além de aumento do trofismo muscular e correção da deformidade.The authors present a case of Guyon's canal syndrome due to a synovial cyst within the left wrist of a 48-year-old female patient. The patient reported pain and paresthesia in the topography of the ulnar nerve, loss of muscular strength and left hand deformity. Electromyography showed a compression of the ulnar nerve at the wrist level. Surgical decompression at the Guyon canal with resection of the cyst was performed. After surgery, the patient presented with improvement of pain and paresthesia, as well as an increase in muscular trophism and correction of the deformity.

  7. Fatores de risco associados à mastite bovina causada por Prototheca zopfii Risk factors associated with bovine mastitis caused by Prototheca zopfii

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    Aline Artioli Machado Yamamura

    2008-06-01

    Full Text Available Este trabalho teve como objetivo o estudo de fatores de risco associados à mastite bovina causada por Prototheca zopfii. Foram analisadas 13 propriedades leiteiras dos Estados do Paraná e de São Paulo, segundo os seguintes critérios de seleção: confirmação prévia de casos de mastite por Prototheca spp., triagem pela pesquisa de Prototheca spp. em tanques de expansão e latões e rebanhos com contagem de células somáticas acima de 5x105cel mL-1. As amostras coletadas consistiram de: leite, água, solo, fezes e swab de teteiras. Prototheca spp. foi isolada de amostras de leite dos quartos mamários com mastite clínica ou subclínica em uma propriedade e de amostras de leite e do ambiente em quatro propriedades, nas quais foi isolada em amostras de: água de bebedouro, abastecimento, esgoto, empoçada no piso de estábulo e sala de ordenha, solo de piquete e pasto, teteiras, fezes de bezerros e suínos. Do total de 383 vacas examinadas, Prototheca spp. foi isolada em 20 (5,2% vacas, sendo caracterizada como P. zopfii em 18. Os fatores de risco associados à mastite causada por P. zopfii foram: criação das vacas a pasto, alimentação dos animais com pasto e silagem, realização de ordenha mecânica em estábulo, permanência das vacas após ordenha em piquete sem alimento, criação de suínos próxima às instalações dos bovinos, existência de cães, gatos e roedores, falta de higienização dos tetos com água, pré-imersão dos tetos em aplicador com retorno e sem a troca do anti-séptico, alimentação dos bezerros com leite de vacas com mastite clínica e serem as vacas da raça holandesa.This research had as objective the study of risk factors associated with bovine mastitis caused by Prototheca zopfii. Thirteen dairy herds in Paraná and São Paulo states were analyzed and selected according to the following criteria: previous confirmation of Prototheca spp. mastitis cases, screening of Prototheca spp. in bulk tanks and

  8. Mancha de mirotécio em algodoeiro causada por Myrothecium roridum Myrothecium leaf spot of cotton caused by Myrothecium roridum

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    Maurício Conrado Meyer

    2006-09-01

    Full Text Available A mancha de mirotécio causada por Myrothecium roridum Tode ex Fr. foi observada em lavouras de algodão no sul do Maranhão, causando reduções de produtividade de até 60%. Os sintomas da doença são lesões necróticas, circulares, com estruturas salientes, os esporodóquios, de distribuição irregular. Foram observadas lesões nos pecíolos, brácteas, folhas e maçãs de algodoeiro cv. Deltapine Acala 90, Fibermax 966 e Sure Grow 821. O isolamento do fungo foi realizado em meio de cultura batata-dextrose-ágar (BDA. O teste de patogenicidade foi realizado em maçãs sadias, destacadas de algodoeiro cv. Fibermax 966, no estádio vegetativo R6, previamente desinfestadas. Foram testados 13 isolados de M. roridum, oito provenientes de algodão e cinco de soja. Avaliações das estruturas fúngicas foram realizadas com auxílio de microscópio óptico equipado com um micrômetro ocular. Os isolados causaram infecções em maçãs de algodão e destacou-se como mais agressivo o MA-75, proveniente de algodão, apresentando diâmetro médio de lesão de 1,3cm, aos sete DAI e 2,7cm aos 14 DAI. Todos os isolados formaram esporodóquios dispostos concenticamente em meio BDA. Os conídios são unicelulares, hialinos a oliváceos, abundantemente produzidos em massa verde-oliva a preta. Os conídios de isolados provenientes de algodão mediram, em média, 5,1µm x 1,5µm, e os obtidos de soja, 5,8µm x 1,5µm. Estes resultados relatam a ocorrência da mancha de mirotécio, causada por M. roridum, em lavouras comerciais de algodão no Brasil.Myrothecium leaf spot caused by Myrothecium roridum Tode ex Fr. was observed on cotton fields in Maranhão State, Brazil, causing yield reduction of up to 60%. Disease symptoms are lesions with concentric necrotic rings, with salient structures (sporodochia irregularly distributed. Symptoms were observed on petioles, bracts, leaves and bolls of cotton cultivars Deltapine Acala 90, Fibermax 966 and Sure Grow 821

  9. ALTERAÇÕES MICROMETEOROLÓGICAS CAUSADAS POR TÚNEIS BAIXOS DE TELA PLÁSTICA PRETA CULTIVADOS COM ALFACE

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    Galileo Adeli Buriot

    1994-01-01

    Full Text Available RESUMO Foram determinadas alterações micrometeorológicas causadas por tela plástica preta com 18, 30 e 50% de atenuação da radiação solar incidente, durante os meses de verão, em Santa Maria, RS. O experimento foi conduzido no Campo Experimental do Departamento de Fitotecnia da UFSM, onde foram cultivados quatro canteiros com alface, três deles cobertos com túneis de tela plástica. O estudo foi realizado em 3 períodos: de 30/11/90 a 17/01/91, de 06/02/91 a 25/03/91 e de 10/12/91 a 01/03/92. Mediu-se a radiação solar global, radiação solar na faixa de comprimento de onda do infravermelho e a luminosidade, temperatura diurna do solo, temperatura mínima e diurna do ar e umidade do solo e do ar. Os resultados mostraram que a temperatura do solo e do ar e a perda de água do solo são menores sob os túneis do que no exterior. As diferenças cresceram com o aumento da atenuação e a temperatura mínima do ar e a umidade relativa do ar são semelhantes no interior e exterior dos túneis e entre os túneis com diferentes percentagens de atenuação.

  10. Utilização da vacina Escherichia coli J5 na imunização de novilhas leiteiras contra mastites causadas por E. coli

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    M.B. Gentilini

    2012-02-01

    Full Text Available Avaliou-se a eficácia da vacina E.coli J5 na prevenção e no controle de mastites causadas por E.coli por meio da análise da prevalência de infecções intramamárias após o parto, ocorrência e intensidade de casos clínicos de mastite nos primeiros 100 dias de lactação, influência na contagem de células somáticas (CCS e produção de leite. As novilhas, n=131, foram distribuídas em três grupos de animais - vacinados três vezes, vacinados duas vezes e não vacinados. As imunizações ocorreram 60 dias antes do parto, 30 dias antes do parto e na primeira semana pós-parto, esta última só para o grupo de três vacinações. Foram coletadas amostras de leite para diagnóstico microbiológico e avaliação da CCS, e registrados os dados relacionados à ocorrência e à intensidade dos casos clínicos e à produção de leite nos primeiros 100 dias de lactação. Não houve redução na prevalência de E.coli no pós-parto de novilhas vacinadas, e houve redução na ocorrência de casos clínicos por E.coli em novilhas vacinadas. Não foram observadas diferenças entre grupos com relação à CCS. Novilhas vacinadas com as três doses apresentaram maior produção de leite. A vacinação com E.coli J5 foi eficaz em reduzir a ocorrência de casos clínicos nos primeiros 100 dias da lactação, mas não interferiu na prevalência de infecções intramamárias após o parto, na intensidade de casos clínicos e na CCS.

  11. Postoperative Alcaligenes xylosoxidans endophthalmitis: report of two cases Endoftalmite pós-operatória causada por Alcaligenes xylosoxidans: relato de dois casos

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    Alejandra de-la-Torre

    2008-02-01

    Full Text Available We report two cases of postoperative Alcaligenes xylosoxidans endophthalmitis. A 78-year-old woman in good general health developed A. xylosoxidans endophthalmitis one month after an uncomplicated phacoemulsification procedure with posterior chamber intraocular lens. It was performed on her left eye, at another institution. Removal of the intraocular lens and capsule was performed because of recurrent inflammation after vitrectomy and intravitreal antibiotic injections. Her son, a 55-year-old man, developed A. xylosoxidans endophthalmitis in his left eye, two months after an uncomplicated phacoemulsification procedure with posterior chamber intraocular lens (it also was performed by the same surgeon. He also required vitrectomy with removal of the intraocular lens and capsule because of persistent disease. A. xyloso - xidans can cause chronic low-grade and progressive endophthalmitis after cataract extraction that is often resistant to corrective antibiotic therapy. This kind of case is rare. There have been only previously reported seven cases worldwide to the best of our knowledge.Relatamos dois casos de endoftalmite pós-operatória causada por Alcaligenes xylosoxidans. Uma mulher de 78 anos de idade e saúde geral boa desenvolveu endoftalmite por A. xylosoxidans um mês após ser submetida a facoemulsificação com implante de lente intra-ocular de câmara posterior, sem complicações. A cirurgia foi realizada no olho esquerdo em outra instituição. A remoção da lente e da cápsula intra-ocular foi realizada em conseqüência da inflamação recorrente após vitrectomia e injeções intravítreas de antibiótico. Seu filho, de 55 anos, desenvolveu endoftalmite por A. xylosoxidans, no olho esquerdo, dois meses após facoemulsificação com implante de lente intra-ocular de câmara posterior (realizada também pelo mesmo cirurgião. Foi necessária também realização de vitrectomia com remoção da lente intra-ocular e da c

  12. Prevalencia y factores de riesgo para infecciones del tracto urinario de inicio en la comunidad causadas por Escherichia coli productor de betalactamasas de espectro extendido en Colombia

    Science.gov (United States)

    Blanco, Victor M.; Maya, Juan J.; Correa, Adriana; Perenguez, Marcela; Muñoz, Juan S.; Motoa, Gabriel; Pallares, Christian J.; Rosso, Fernando; Matta, Lorena; Celis, Yamile; Garzon, Martha; Villegas, y María V.

    2016-01-01

    RESUMEN Introducción Las infecciones del tracto urinario (ITU) son frecuentes en la comunidad. Sin embargo, la información de aislamientos resistentes en este contexto es limitada en Latinoamérica. Este estudio tiene como objetivo determinar la prevalencia y los factores de riesgo asociados con ITU de inicio en la comunidad (ITU-IC) causadas por Escherichia coli productor de betalactamasas de espectro extendido (BLEE) en Colombia. Materiales y métodos Entre agosto y diciembre de 2011 se realizó un estudio de casos y controles en 3 instituciones de salud de tercer nivel en Colombia. Se invitó a participar a todos los pacientes admitidos a urgencias con diagnóstico probable de ITU-IC, y se les pidió una muestra de orina. En los aislamien-tos de E. coli se realizaron pruebas confirmatorias para BLEE, susceptibilidad antibiótica, caracterización molecular (PCR en tiempo real para genes bla, repetitive element palindromic PCR [rep-PCR], multilocus sequence typing [MLST] y factores de virulencia por PCR). Se obtuvo información clínica y epidemiológica, y posteriormente se realizó el análisis estadístico. Resultados De los 2.124 pacientes seleccionados, 629 tuvieron un urocultivo positivo, en 431 de estos se aisló E. coli, 54 fueron positivos para BLEE y 29 correspondieron a CTX-M-15. La mayoría de los aislamientos de E. coli productor de BLEE fueron sensibles a ertapenem, fosfomicina y amikacina. La ITU complicada se asoció fuertemente con infecciones por E. coli productor de BLEE (OR = 3,89; IC 95%: 1,10–13,89; p = 0,03). E. coli productor de CTX-M-15 mostró 10 electroferotipos diferentes; de estos, el 65% correspondieron al ST131. La mayoría de estos aislamientos tuvieron 8 de los 9 factores de virulencia analizados. Discusión E. coli portador del gen blaCTX-M-15 asociado al ST131 sigue siendo frecuente en Colombia. La presencia de ITU-IC complicada aumenta el riesgo de tener E. coli productor de BLEE, lo cual debe tenerse en cuenta para ofrecer

  13. Utilização da vacina Escherichia coli J5 na imunização de vacas leiteiras contra mastites causadas por E. coli

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    Lívio R. Molina

    2013-03-01

    Full Text Available Avaliou-se a utilização da vacina Escherichia coli J5, na imunização de vacas leiteiras, para prevenção e controle da mastite causada por E. coli através da análise da prevalência das infecções intramamárias (IMM no pós-parto, ocorrência e intensidade dos casos clínicos de mastite nos primeiros 100 dias de lactação, influência na contagem de células somáticas (CCS e produção de leite. O grupo experimental foi composto de 187 animais, divididos em 2 grupos, vacas vacinadas e não vacinadas. As imunizações ocorreram 60 dias antes do parto, 30 dias antes do parto e na primeira semana pós-parto. No dia da secagem e sete dias após o parto foram coletadas amostras para diagnóstico microbiológico dos patógenos causadores de mastite. A ocorrência de casos clínicos foi verificada pelo teste da caneca durante as ordenhas sendo registrados os dados relacionados à intensidade. Amostras foram coletadas mensalmente, a partir do décimo dia de lactação, para avaliação da CCS. A produção de leite foi registrada mensalmente nos primeiros 100 dias de lactação. Verificou-se no grupo vacinado, redução na prevalência de E. coli no pós-parto, na ocorrência de casos clínicos por E.coli nos primeiros 100 dias de lactação bem como na intensidade destes casos clínicos. Não foram observadas diferenças estatísticas significativas na CCS, entretanto vacas vacinadas apresentaram maior produção de leite, comparadas às vacas não vacinadas. A vacinação com E. coli J5 foi eficaz em reduzir a prevalência de infecções intramamárias (IMM ao parto, ocorrência e intensidade dos casos clínicos e aumento na produção de leite nos primeiros 100 dias de lactação.

  14. Paraplegia aguda por compressão da medula espinhal torácica causada por tofo gotoso Acute paraplegia resulting from spinal cord compression by tophaceous gout

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    Eduardo Massato Hasegawa

    2007-08-01

    Full Text Available O acometimento axial pela gota é um evento raro, e o envolvimento da coluna torácica foi descrito em apenas 17 casos na literatura. Apresentamos um caso de paciente do sexo masculino de 48 anos com história de gota, sob tratamento irregular com alopurinol e colchicina, que desenvolveu paraplegia aguda decorrente de compressão medular por tofo gotoso. Realizou-se o diagnóstico por meio de ressonância magnética e anatomia patológica. Foi tratado com antiinflamatórios e descompressão cirúrgica com melhora importante, porém parcial. Apesar de o acometimento medular pelo tofo ser um evento raro, deve ser considerado nos casos de síndrome de compressão medular em pacientes com antecedente de gotaAxial gout is a rare condition and the involvement of the thoracic spine has been described only 17 times in the literature. This paper presents the case of a 48 year-old male patient with a history of gout, under irregular treatment with allopurinol and colchicines, who developed acute paraplegia resulting from spinal cord compression by tophaceous gout. The diagnosis was made using magnetic resonance imaging and anatomic pathology. The patient was treated with anti-inflammatory drugs and surgical decompression and showed important, albeit partial, improvement. Thus, although tophi rarely affect the spinal cord, they should be considered as a possibility in cases of spinal cord compression syndrome in patients with a history of gout

  15. Frecuencia de infecciones respiratorias inferiores causadas por el virus sincitial respiratorio, en niños menores de dos años, hospitalizados en el servicio de pediatría del Hospital Vicente Corral Moscoso, Cuenca, 2008

    OpenAIRE

    Célleri Gomescoello, Alba Milena; Jerez Cárdenas, Doris Patricia; Ortíz Hinojosa, María Fernanda

    2009-01-01

    Con el objetivo de determinar la frecuencia de infecciones respiratorias agudas bajas (IRABs) causadas por el virus sincitial respiratorio (VSR), en niños menores de dos años, hospitalizados en el servicio de pediatría del hospital Vicente Corral Moscoso. Materiales y métodos: estudio descriptivo, realizado en 163 niños/as menores de 2 años de edad, con infección respiratoria aguda baja. Se estudió al universo, es decir al total de la población seleccionada durante el período de 6 meses. Se e...

  16. Incidência da varíola, causada por Asperisporium caricae, em folhas de mamoeiros submetidos ao manejo orgânico, em diferentes ambientes de cultivo

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    Luiz Aurélio Peres Martelleto

    2009-12-01

    Full Text Available Mudas de mamoeiro da cultivar Baixinho de Santa Amália foram transplantadas para covas de 40x60x40 cm, em áreas de três estruturas contíguas: (a estufa sombreada (cobertura de plástico, (b estufa sombreada + sombrite (cobertura adicional de sombrite com 30% de sombreamento sobre o plástico e (c telado (cobertura exclusiva de sombrite 30%. Ao lado de tais estruturas foi implantada uma área de cultivo de mamoeiro em ambiente natural. Os tratos culturais aplicados foram os condizentes às normas técnicas vigentes na agricultura orgânica. As irrigações foram procedidas com mangueira plástica, evitando-se molhar folhas e frutos. Aos 45 dias pós-transplantio e, subseqüentemente, a intervalos mensais, as plantas foram inspecionadas em relação à incidência de lesões foliares causada pelo fungo Asperisporium caricae. Para efeito de análise estatística, após o teste de homogeneidade das variâncias, foram consideradas quatro repetições por ambiente (tratamento, com seis plantas úteis por parcela. O modelo de quantificação da doença indicou efeito altamente significativo dos ambientes protegidos, estufa e estufa sombreada, quanto à incidência de sintomas, em comparação com ambientes de telado e em área natural de cultivo. Durante os 12 meses de avaliações foi constatada alta correlação entre incidência da doença e pluviosidade e umidade relativa do ar. As estruturas cobertas com plástico demonstraram alto potencial de controle de A. caricae, sendo, portanto, recomendáveis no sistema orgânico de produção do mamoeiro.Transplants of Baixinho de Santa Amália papaya cultivar were grown in three neighboring plant growth facilities: a greenhouse (covered with plastic sheet; b shaded greenhouse (with sombrite 30% black screen over the plastic sheet; c screenhouse (covered with sombrite 30% only. Next to such structures a plot was settled for cultivation under natural environment. Cultural practices were conducted

  17. Nucleotídeos na dieta de frangos de corte e seus efeitos sobre taxa de turnover da mucosa intestinal antes e após lesões causadas por coccidiose

    OpenAIRE

    Pelícia,Vanessa Cristina; Zavarize, Kelen Cristiane [UNESP; Ducatti, Carlos [UNESP; Stradiotti,Ana Cristina; Pezzato, Antonio Celso [UNESP; Araujo, Priscila Cavalca de [UNESP; Mituo,Mariela Akie Okino; Madeira,Luciene Aparecida; Sartori,José Roberto

    2011-01-01

    O objetivo deste trabalho foi avaliar o efeito da dieta suplementada com nucleotídeos sobre taxa de turnover da mucosa intestinal de frangos antes e após lesões causadas por coccidiose por meio de análise isotópica, utilizando a variação do carbono-13 em plantas C3 e C4. Foram utilizados 264 pintos submetidos a dois tratamentos: dieta controle e dieta suplementada com 0,07% nucleotídeos. Os pintos possuíam sinais isotópicos em seus tecidos semelhantes ao de ditas C4. Após o alojamento, para a...

  18. Eficácia do moxalactam no tratamento de meningites purulentas causadas por Haemophilus infuenzae e Neisseria meningitidis Efficacy of moxalactam in the treatment of purulent meningitis caused by Haemophilus influenzae and Neisseria meningitidis

    Directory of Open Access Journals (Sweden)

    Hagamenon R. da Silva

    1984-03-01

    Full Text Available Foi avaliada a eficácia do moxalactam no tratamento de meningites em crianças, causadas por H. influenzae (27 casos e N.meningitidis (6 casos. Dos 33 doentes tratados na dose de 100mg/Kg de peso (dose de ataque e 50mg de 12/12 horas por via venosa, 32 curaram-se. A tolerância ao produto foi muito boa, havendo alterações transitórias de transaminases e fosfatase alcalina; em um caso, houve hematoma posapendectomia, provavelmente relacionado ao uso deste antibiotico. Os níveis séricos e liquóricos do produto foram elevados; as concentrações no liquor excederam de muito a concentração bactericida mínima dos germes infectantes. O moxalactam se mostrou seguro e eficaz como terapia primária da meningite causada por H. influenzae e N.meningitidis em crianças.The clinical efficacy and safety of Moxalactam in purulent bacterial meningitis in children caused by H. influenzae (27 patients and N. meningitidis (6 patients was tested in a randon uncontrolled study. Clinical response was considered excelent, with cure of 32 of 33 patients. High levels of Moxalactam were achieved in the blood and cerebro-spinal fluid, with concentrations largely exceeding the minimum bacterial concentration (MIC for the infecting organisms. Tolerance was considered good, with only transient increases of transaminases and alkaline phosphatase in some patients; also, one patient developed a wound hematoma possibly related to Moxalactam therapy.

  19. Uveíte por tuberculose em um centro de referência no Sudeste do Brasil Tuberculous uveitis at a referral center in southeastern Brazil

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    Wesley Ribeiro Campos

    2008-02-01

    Full Text Available OBJETIVO: Descrever a ocorrência de uveíte por tuberculose (UTB em um centro de referência em Minas Gerais, Brasil. MÉTODOS: Um total de 16 pacientes (idade > 15 anos atendidos consecutivamente de janeiro de 2001 a julho de 2004 no Centro de Referência de Uveíte do Estado de Minas Gerais para avaliação diagnóstica de uveíte foi selecionado para este estudo. Foram coletados dados demográficos e clínicos, assim como dados sobre avaliação para toxoplasmose, sífilis e doenças reumatológicas, teste tuberculínico e sorologia anti-HIV. RESULTADOS: Dos 16 pacientes, 11 (69% tinham UTB. História prévia de contato com tuberculose pulmonar foi relatada por 72% (8/11 dos pacientes do grupo com UTB e por 20% (1/5 dos pacientes do grupo sem UTB. Embora a razão de chances para essa associação tenha sido de 10,67 (IC95%: 0,59-398,66, o valor de p apresentou significância limítrofe (0,078. Não houve diferença quanto ao quadro ocular inflamatório e ao resultado do teste tuberculínico entre os pacientes com UTB e os sem UTB. Todos os pacientes tinham sorologia negativa para o HIV e foram acompanhados por 2 anos. CONCLUSÕES: Neste estudo, a história prévia de contato com tuberculose pulmonar foi de grande ajuda para o diagnóstico da UTB.OBJECTIVE: To describe the occurrence of tuberculous uveitis (TBU at a referral center in the state of Minas Gerais, Brazil. METHODS: A total of 16 consecutive patients (>15 years of age who underwent diagnostic evaluation of uveitis between January of 2001 and July of 2004 at the Minas Gerais State Referral Center were selected for study. Demographic and clinical data, as well as data related to screening for toxoplasmosis, syphilis, and rheumatologic diseases, together with the results of tuberculin skin testing and HIV testing, were collected. RESULTS: Of the16 patients evaluated, 11 (69% were found to have TBU. A history of contact with pulmonary tuberculosis was reported by 8 (72% of the 11

  20. HLA in Brazilian Ashkenazic Jews with chronic dermatophytosis caused by Trichophyton rubrum Antígenos Leucocitários Humanos (HLA em Judeus Ashkenazitas Brasileiros portadores de dermatofitose crônica causada por Trichophyton rubrum

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    Aya Sadahiro

    2004-06-01

    Full Text Available The frequency of HLA (Human Leucocyte Antigens was analyzed in 25 non-consanguineous Brazilian Ashkenazic Jews, resident in the city of São Paulo, Brazil, suffering from chronic dermatophytosis caused by T. rubrum, and in 25 non-infected individuals belonging to the same ethnic group. Statistically significant values (pA freqüência dos HLA foi analisada em 25 Judeus Ashkenazitas, não consangüíneos, residentes em São Paulo, Brasil, com dermatofitose crônica causada por T. rubrum e em 25 indivíduos sadios, pertencentes ao mesmo grupo étnico dos pacientes. Observou-se valor estatisticamente significante (p<0,05 para HLA-B14 associado a resistência à dermatofitose crônica enquanto HLA-DQB1*06 (p=0,05 possivelmente relacionado a susceptibilidade. Estes achados indicam que o desenvolvimento da dermatofitose crônica pode ser influenciado por genes localizados no cromossomo 6, na região do complexo principal de histocompatibilidade.

  1. Infecções urinárias causadas por Trichosporon spp. em pacientes graves internados em unidade de terapia intensiva

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    Maria das Graças Silva Mattede

    2015-09-01

    Full Text Available RESUMOObjetivo:Avaliar a incidência de infecções do trato urinário por Trichosporon spp. em uma unidade de terapia intensiva.Métodos:Estudo descritivo observacional realizado em uma unidade de terapia intensiva no período de 2007 a 2009. Foram analisados todos os pacientes consecutivos que internaram na unidade de terapia intensiva e tiveram o diagnóstico confirmado.Resultados:Vinte pacientes apresentaram infecções do trato urinário por Trichosporon spp. A prevalência foi maior no sexo masculino (65% e na faixa etária superior a 70 anos (55%. A mortalidade foi de 20%. A média de permanência na unidade de terapia intensiva foi de 19,8 dias. Seu aparecimento esteve relacionado ao uso pregresso de antibióticos e foi mais frequente no período que compreendeu o outono e o inverno.Conclusão:A infecção por Trichosporon spp. predominou no sexo masculino, de idade acima de 70 anos, com uso de sonda vesical de demora por mais de 20 dias e com uso de antibióticos de amplo espectro acima de 14 dias. Os pacientes que apresentaram a infecção urinária por Trichosporon spp. ficaram internados nos setores de terapia intensiva, com maior frequência, no período de outono e inverno.

  2. Análisis de las fallas en transformadores causadas por la operación del pararrayos ante sobretensiones externas

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    Francisco Román Campos

    2011-02-01

    Full Text Available Uno de los problemas más graves que afronta el Sector Eléctrico Colombiano, es el alto índice de fallas de transformadores de distribución, que para el caso de la reglón central del país, servida por la Empresa de Energía Eléctrica de Bogotá -EEB-, significó cerca de 983 millones de pesos en el año 1987. De los análisis de fallas realizadas por la EEB, se desprende que un alto porcentaje de las mismas pueden deberse a Descargas Eléctricas Atmosféricas. El presente articulo tiene por objeto analizar este tipo de fallas y explicar mediante el concepto de los llamados "Lazos Inductivos" -que tienen su aplicación en los estudios de protección contra rayos directos en pararrayos tipo Franklin-; lo que unido a la alta resistividad del terreno, los drásticos cambios de Impedancia en el sitio de Instalación del pararrayos, las variaciones rápidas de la corriente asociadas a los rayos negativos y las tensiones Inducidas por descargas Indirectas, producen sobretensiones hasta ahora no consideradas y de magnitudes insospechadas en los transformadores de distribución. Como conclusión a este trabajo se plantea un cambio en la filosofía de Instalación de los transformadores de distribución, lo que respaldado por un estudio profundo de los modelos propuestos, puede conducir a una modificación de las normas nacionales de instalación del conjunto transformador-pararrayos, con la consecuente reducción de los costos por quema de los mismos, en cifras anuales que pueden ser del orden de 5 millones de dólares en todo el territorio colombiano.

  3. OCCURRENCE OF LEAF SPOTS CAUSED BY FUNGI AND A BACTERIUM ON COTTON CULTIVARS OCORRÊNCIA DE MANCHAS FOLIARES CAUSADAS POR FUNGOS E BACTÉRIA EM CULTIVARES DE ALGODOEIRO

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    Miguel Ferreira Soria

    2008-11-01

    Full Text Available

    The cotton leaf spot diseases caused by fungi and bacteria are a growing problem, leading to an increasing use of fungicides. During the 2000/2001 and 2001/2002 growing seasons, field experiments were carried out in a randomized block design, with five replications, aiming to evaluate the behavior of the cotton cultivars Ita-90, CD-401, CD-402, CD-403, CD-404, Fibermax 986, DeltaOpal, and Facual, as related to leaf spot diseases caused by Stemphylium spp., Alternaria spp., Ramularia areola, and the bacterium Xanthomonas axonopodis pv. malvacearum. The cotton cultivars Ita-90 and Facual were the less susceptible to the Stemphylium/Alternaria complex and R. areola. However, Ita-90 was more susceptible to X. axonopodis pv. Malvacearum. The cultivars with the least incidence of X. axonopodis were CD-403, Fibermax 986, and DeltaOpal. The cotton cultivar Facual presented the lowest yield, while the remaining cultivars showed similar yields.

    KEY-WORDS: Xanthomonas axonopodis pv. Malvacearum; Stemphylium spp; Alternaria spp; Ramularia areola.

    As manchas foliares causadas por fungos e bactérias no algodoeiro são um problema cada vez mais grave, levando à utilização, cada vez maior, de fungicidas para controlá-las. Nas safras de 2000/2001 e 2001/2002, foram realizados experimentos m campo, em delineamento de blocos ao acaso, com cinco epetições, objetivando avaliar o comportamento das

  4. Reação leucemoide e anemia hemolítica grave causada por Mycoplasma pneumoniae Leukemoid reaction and severe hemolytic anemia due to Mycoplasma pneumoniae

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    Kléber G. Luz

    2010-02-01

    Full Text Available Hemólise massiva é uma manifestação rara da infecção por Mycoplasma pneumoniae.É desencadeada por crioaglutininas, anticorpos IgM, que surgem sete a dez dias após a infecção em cerca de 50% a 75% dos casos. Hiperleucocitose é também evento incomum e orienta o diagnóstico para etiologia bacteriana ou neoplásica. Relatamos um caso de um homem de 67 anos com pneumonia por Mycoplasma pneumoniae, que apresentou anemia grave e reação leucemoide, diagnosticada por meio do teste de crioaglutininas à beira do leito e dosagem do título de anticorpo anti-mycoplasma. Após início do tratamento adequado, houve melhora importante da anemia e a leucometria foi reduzida de 56.100/mm³ para valores próximos do normal.Massive hemolysis, a rare manifestation of Mycoplasma pneumoniae infection, is due to cold agglutinins (IgM antibodies that appear seven to ten days after the infection in around 50% to 70% of cases. Hyperleukocytosis, suggestive of bacterial or neoplastic etiologies, is also an uncommon event. We report here on the case of a 67-year-old man with Mycoplasma pneumoniae pneumonia who presented with severe anemia and leukemoid reaction as diagnosed by the bedside cold agglutinin test and measurement of anti-mycoplasma antibodies. After beginning appropriate treatment, the anemia improved significantly and the leukocyte count reduced from 56100 /mm³ to close to normal level.

  5. Miocarditis difusa reagudizada, Cardiomiopatía dilatada causada por trypanosoma cruzi y su detección en medicina nuclear

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    Victor Cesar Lugo Espinoza

    2013-12-01

    Full Text Available La miocarditis es la inflamación del corazón de etiología múltiple, es una enfermedad insidiosa, usualmente asintomática y es una causa importante de muerte repentina en adultos jóvenes. En Sudamérica la enfermedad de Chagas es la causa principal de miocarditis, y conlleva a la cardiomiopatía dilatada que es considerada como un síndrome clínico y fisiopatológico caracterizada por disfunción del miocardio, de la conducción eléctrica y dilatación de las cavidades del corazón, que predispone a la insuficiencia cardiaca y al desencadenamiento de muerte súbita. El diagnóstico de la miocarditis es dificultoso, a veces la clínica no nos aporta suficiente información y los exámenes complementarios específicos son invasivos, por eso debemos resaltar el uso de los métodos nucleares en el diagnóstico. La Gammagrafía cardiaca es un estudio radioisotópico del corazón con pirofosfato Tecnecio 99m o Galio 67, ambos se distribuyen específicamente por el tejido cardiaco inflamado.

  6. Aspectos epidemiológicos de pacientes com lesões ungueais e cutâneas causadas por Scytalidium spp Epidemiological aspects of patients with ungual and cutaneous lesions caused by Scytalidium spp

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    Ana Paula Martins Xavier

    2010-12-01

    Full Text Available FUNDAMENTO: As dermatomicoses causadas por fungos filamentosos não dermatófitos são infecções raras, exceto as onicomicoses, cuja prevalência vem crescendo nos últimos anos. Dentre esses agentes etiológicos destacam-se o Scytalidium dimidiatum e o S. hyalinum, fungos emergentes responsáveis por micoses em unhas e pele. OBJETIVO: Investigar as características epidemiológicas das onicomicoses e micoses de outras localizações causadas pelos fungos do gênero Scytalidium, utilizando-se como parâmetros sexo, idade e localizações das lesões. MÉTODOS: Avaliaram-se 81 amostras com cultura positiva para o gênero em estudo, oriundas de 74 pacientes encaminhados ao Laboratório de Investigação em Dermatologia (ID situado na cidade do Rio de Janeiro (RJ, no período de 1997 a 2006. As amostras foram submetidas a confirmação diagnóstica por exame direto e cultura. RESULTADOS: A prevalência de onicomicoses por Scytalidium spp. foi de 0,87%, entre as idades de 41 e 60 anos (48,64%. Em relação à localização das lesões, os pés foram mais acometidos (91,36%, com predomínio do hálux esquerdo. No exame direto, as estruturas mais encontradas foram hifas hialinas; na cultura, a espécie S. dimidiatum foi a mais frequente. CONCLUSÃO: As onicomicoses por Scytalidium spp. são raras e o S. dimidiatum foi a espécie mais isolada neste laboratório no período em estudo.BACKGROUND: Dermatomycoses caused by non-dermatophyte filamentous fungi are rare infections, except for onychomycosis, whose prevalence has increased over the past few years. Among these etiologic agents, we highlight Scytalidium dimidiatum and S. hyalinum, emergent fungi that cause mycoses that affect the nails and skin. OBJECTIVE: To investigate the characteristics of onychomycosis and other mycoses caused by the fungi Scytalidium spp, using sex, age and site of infection as parameters. METHODS: Eighty-one samples were evaluated showing positive culture for Scytalidium

  7. Restrições causadas pela incontinência urinária à vida da mulher Restricciones ocasionadas por la incontinencia urinaria en la vida de la mujer Urinary incontinence restrictions in women's life

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    Maria Helena Baena de Moraes Lopes

    2006-03-01

    Full Text Available O objetivo deste estudo foi identificar as restrições causadas pela incontinência urinária (IU à vida da mulher, considerando-se o tipo de incontinência, e verificar como manejam este problema. Trata-se de uma análise secundária de dados obtidos em estudo anterior, coletados por meio de entrevista com perguntas abertas e fechadas. A amostra foi composta por 164 mulheres com queixa de IU, internadas em clínicas de ginecologia e urologia de dois hospitais-escola da cidade de Campinas, SP. Apresentavam idade entre 25 e 85 anos e 104 (64% referiram uma ou mais restrições. Citaram alterações nas atividades sexuais (40,9%, sociais (33,5%, domésticas (18,9% e ocupacionais (15,2%. A incontinência urinária mista e a de urgência forem as que mais afetavam a vida das mulheres. A estratégia mais utilizada para minimizar a IU foi o uso de forro e/ou absorvente higiênico. Concluiu-se que a IU tem implicações negativas no cotidiano dessas mulheres.En este estudio se tuvo como objetivo identificar las restricciones causadas por la incontinencia urinaria (IU en la vida de la mujer, considerándose el tipo de incontinencia, y verificar cómo manejan este problema. Se trata de un análisis secundario de datos obtenidos en un estudio anterior, recolectados por medio de entrevista con preguntas abiertas y cerradas. La muestra estuvo compuesta por 164 mujeres con queja de IU, internadas en clínicas de ginecología y urología de dos hospitales docentes de la ciudad de Campinas, SP. Las mujeres tenían entre 25 y 85 años de edad, habiendo relatado 104 (64% de ellas una o más restricciones. Citaron alteraciones en las actividades sexuales (40,9%, sociales (33,5%, domésticas (18,9% y ocupacionales (15,2%. La incontinencia urinaria mixta y la de urgencia fueron las que más afectaban la vida de las mujeres. La estrategia más utilizada para minimizar la IU fue el uso de paños y/o toallas higiénicas. Se concluyó que la IU tiene implicancias

  8. Anemia hemolítica causada por Indigofera suffruticosa (Leg. Papilionoideae em bovinos Hemolytic anemia caused by Indigofera suffruticosa (Leg. Papilionoideae in cattle

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    José Diomedes Barbosa Neto

    2001-03-01

    Full Text Available As partes aéreas de Indigofera suffruticosa Mill. (família Leg. Papilionoideae, planta incriminada pelos criadores de diversas áreas do Nordeste por doença caracterizada por hemoglobinúria em bovinos, foram administradas por via oral a seis bovinos, em doses diárias repetidas de 10 a 40 g/kg, Todos os animais experimentais apresentaram hemoglobinúria, porém passageira, apesar continuidade da administração da planta. Dois desses bovinos não apresentaram manifestações adicionais, um terceiro animal evidenciou manifestações leves, e os três outros, sintomas adicionais de intensidade moderada: apatia, mucosas visíveis de coloração esbranquiçada, pêlos arrepiados, anorexia, diminuição da freqüência e intensidade dos movimentos ruminais, taquicardia, pulso venoso positivo e dispnéia. Antes da crise hemolítica a urina apresentava coloração verde azulada. Nenhum animal experimental morreu, porém um foi sacrificado durante a fase hemoglobinúrica. À necropsia observaram-se anemia, bexiga contendo urina cor de vinho tinto, rins aumentados de volume com coloração marrom-escura, fígado, na superfície e ao corte, de coloração azulada com lobulação perceptível. As principais alterações histológicas foram verificadas no fígado, sob forma de necrose coagulativa e tumefação e/ou microvacuolização citoplasmática dos hepatócitos, e no rim representadas por acentuada nefrose, associada a grande quantidade de filtrado e/ou hemoglobina nos espaços de Bowman dentro de túbulos e do citoplasma das células epiteliais.The aereal parts of Indigofera suffruticosa Mill. (family Leg. Papilionoideae were force-fed fresh to 6 bovines in daily doses of 10 to 40 g/kg. Cattle breeders of various parts of the Northeast of Brazil accuse this plant as the cause of a non-fatal disease characterized by hemoglobinuria. The disease occurs only in years when the plant proliferates well invading the native pastures. All experimental

  9. Cerebral ischemia caused by Streptococcus bovis aortic endocarditis: case report Isquemia cerebral causada por endocardite aórtica pelo Streptococcus bovis: relato de caso

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    Leopoldo Santos-Neto

    2005-09-01

    Full Text Available Cerebral ischemic processes associated with infective endocarditis caused by Streptococcus bovis are rare; only 2 cases having been reported. Here we report a case of a 50-year-old man with S. bovis endocarditis who presented signs of frontal, parietal and occipital lobe cerebral ischemia. This is the first case reported in which the presence of hemianopsia preceded the endocarditis diagnosis. Initially, the clinical manifestations suggested a systemic vasculitis. Later, vegetating lesions were identified in the aortic valve and S. bovis grew in blood cultures. Antibiotic use and aortic valve replacement eliminated the infection and ceased thromboembolic events. A videocolonoscopy examination revealed no mucosal lesions as a portal of entry in this case, although such lesions have been encountered in up to 70% of reported cases of S. bovis endocarditis.A associação de isquemia cerebral e endocardite por Streptococcus bovis é um evento raro, tendo sido publicados apenas 2 casos anteriormente. Nós relatamos o caso de um homem de 50 anos com endocardite por S. bovis que apresentou sinais isquêmicos nos lobos frontal, parietal e occipital. Este é o primeiro caso em que a hemianopsia precedeu o diagnóstico de endocardite. Inicialmente, o quadro foi confundido com vasculite. Posteriormente, foi confirmada a presença de vegetações na válvula aórtica e a hemocultura identificou S. bovis. Os eventos tromboembólicos foram controlados com o uso de antibióticos e a troca da válvula aórtica. Estudo videocolonoscópico não identificou nenhuma lesão, apesar de lesões colônicas serem descritas em até 70% dos casos de indivíduos com endocardite por S. bovis.

  10. Evaluación de la mutagenicidad causada por metales pesados presentes en agua del río Cauca en la ciudad de Cali, Colombia

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    Aura H. Vivas

    2014-05-01

    Full Text Available Se evaluó la mutagenicidad del agua del río Cauca debida a la presencia de metales pesados en la zona urbana de la Ciudad de Santiago de Cali, a partir de muestras tomadas en la temporada seca y lluviosa en el año 2013. Los metales se extrajeron pasando el agua por la resina Amberlite XAD-16. Las concentraciones de los metales pesados se midieron por absorción atómica y la mutagenicidad se evaluó por medio del test de Ames, con las cepas TA98 y TA100 de Salmonella typhimurium con y sin activador enzimático S9. Los resultados mostraron índices de mutagenicidad (IM positivos (IM > 2,0 para muestras colectadas en temporada lluviosa en tres de los cinco puntos evaluados: puente El Hormiguero (IM = 3,6, desembocadura del Canal Colector Sur (IM = 2,9 y desembocadura del río Cali (IM = 2,7, todos con la cepa TA98 sin S9. Estos sitios presentaron a su vez las mayores concentraciones totales de metales pesados en sus extractos. El análisis de la variación espacio-temporal del índice mutagénico se realizó haciendo un análisis de varianza multifactorial del IM. Los resultados encontrados indican que la época de muestreo contribuye significativamente a la variabilidad del IM, mientras que los puntos de muestreo no.

  11. Infecções humanas causadas por poxvirus relacionados ao vírus vaccinia no Brasil Human infections caused by vaccinia-like poxviruses in Brazil

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    Hermann G. Schatzmayr

    2009-12-01

    Full Text Available A partir de 1999, infecções humanas por Orthopoxvirus vem sendo observadas em pelo menos oito estados no país, com a formação de vesículas as quais evoluem para pústulas e crostas, principalmente nos membros superiores e face, após contacto com bovinos apresentando lesões semelhantes no úbere. Alem das lesões na pele, foram descritas nos pacientes reações ganglionares axilares por vezes dolorosas, febre, cefaléia, fadiga, desidratação, anorexia, sudorese, artralgia e mialgia, evoluindo o quadro por três a quatro semanas. Lesão vulvar bem como transmissão intrafamiliar foram igualmente descritas. Estudos moleculares demonstraram que os poxvirus identificados são geneticamente relacionados a amostras do vírus vaccinia utilizadas no passado, nas campanhas de vacinação. Especimens clínicos de 80 infecções humanas foram estudados no laboratório e a infecção por orthopoxvirus confirmada em 68 casos. São apresentadas lesões observadas em pacientes bem como discutidas as implicações desta zoonose no Brasil.Since 1999, human infection caused by Orthopoxvirus has been observed in at least eight Brazilian states, with the presence of vesicles that evolve to pustules and crusts, especially on the hands, arms and face, after contact with cows showing comparable lesions on the udder. In addition to the skin lesions, there have been descriptions of patients with axillary ganglionic reactions that are sometimes painful, along with fever, headache, fatigue, dehydration, anorexia, sudoresis, arthralgia and muscle pain. The condition evolves over a three to four-week period. Vulvar lesions and transmission within families have also been described. Molecular studies have shown that the poxviruses identified are genetically related to vaccinia virus samples that were used in vaccination campaigns in the past. Clinical specimens from 80 human infections were studied in the laboratory, and orthopoxvirus infections were confirmed in 68

  12. Luxação traumática do bulbo ocular causada por acidente doméstico Traumatic eyeball luxation caused by domestic accident

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    Rogério de Almeida Tárcia

    2007-12-01

    Full Text Available A luxação do bulbo ocular ocorre quando há seu deslocamento anterior, de tal forma que as pálpebras se fecham espasmodicamente por detrás dele. Diversas causas não traumáticas são relatadas, sendo que, quando provocado por traumas contusos, com grande envolvimento do nervo óptico e da musculatura extrínseca ocular, o prognóstico em geral é desfavorável. Apresentamos um dramático caso de luxação do bulbo ocular em criança após acidente doméstico, destacando seu mecanismo fisiopatológico e apreciando as condutas.The eyeball luxation is a dramatic phenomenon in which there is a forward displacement of the eyeball so that the eyelids spasmodically close behind it. There are many risk factors, non-related to trauma, but orbital contusions with optic nerve and extraocular muscles involvement carry the worst prognosis. The present paper reports a dramatic domestic case of globe luxation in childhood, its pathophysiology mechanisms and management.

  13. Controle químico da podridão peduncular causada por Lasiodiplodia theobromae em mangas Chemical control stem rot caused by Lasiodiplodia theobromae on mangoes fruits

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    Rui Sales Júnior

    2009-09-01

    Full Text Available O presente estudo objetivou avaliar a eficiência do ingrediente ativo difenoconazole, em diferentes doses, comparando-as com outros ingredientes ativos, no controle da podridão peduncular em manga 'Tommy Atkins'. O delineamento experimental utilizado foi o de blocos casualizados, com quatro repetições de nove plantas cada. Os tratamentos foram compostos pelos seguintes fungicidas e doses de princípio ativo: difenoconazole (75; 100; 125 mL.ha-1, azoxistrobina (80 g.ha-1, acrescido de 0,05% de nonifenol etoxilado, clorotalonil (1.237,5 g.ha-1, propiconazole (100 mL.ha-1; e testemunha, sem aplicação de fungicida. Foram realizadas seis aplicações, com intervalo de 15 dias, sendo a primeira na floração plena. Na colheita, foram amostrados aleatoriamente 25 frutos por parcela, os quais foram mantidos em condição ambiente por 15 dias. Não houve diferença significativa entre as doses testadas, porém todos os tratamentos diferiram da testemunha. O difenoconazole apresentou resultado satisfatório em todas as doses utilizadas, podendo ser recomendado no controle desta doença.This work aimed to evaluate the difenoconazole fungicide efficiency to control stem rot in mango fruits cv. Tommy Atkins. The experiment was carried out in a randomized blocks design, with four repetitions of nine plants. The treatments was compound by the respective fungicides and doses: difenoconazole (75; 100; 125 L.ha-1, azoxystrobin (80 g.ha-1, including 0,05% of nonylphenol ethoxylate, chlorothalonil (1.237,5 kg.ha-1, propiconazole (100 mL.ha-1, and control, without fungicide application. Six fungicide applications were realized, with 15 days interval, with the first at the panicles blooming. Twenty five fruits per plot were collected for evaluation, being stored under ambient conditions in plastic containers for 15 days. There was no significant difference between the tested doses, however all the treatments with fungicide differed from the control treatment

  14. Fatal septicemia caused by Chromobacterium violaceum in a child from Colombia Septicemia mortal causada por Chromobacterium violaceum en una paciente pediátrica de Colombia

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    Pedro Martinez

    2007-12-01

    Full Text Available A 4-year old child living in Colombia presented with a history of fever and severe abdominal pain for four days. The patient developed pneumonia, septic shock, multiple organ failure and died on the fifth day of hospitalization. Chromobacterium violaceum was isolated from admission blood cultures and was resistant to ampicillin, cephalosporins, carbapenems and aminoglycosides.Una niña de 4 años que vivía en Colombia presentó historia de fiebre y dolor abdominal severo por cuatro días. La paciente desarrollo neumonía, shock séptico, múltiple falla de órganos y muerte el quinto día de hospitalización. Chromobacterium violaceum fue aislado de cultivos de sangre y mostró resistencia a ampicilina, cefalosporinas, carbapenems y aminoglicosidos.

  15. Thermolysed and active yeast to reduce the toxicity of aflatoxin Formas termolisada e viva de leveduras na redução de toxicidade causada por aflatoxinas

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    Antonio Sampaio Baptista

    2002-06-01

    Full Text Available Aflatoxins are hepatotoxic metabolites produced by Aspergillus flavus and A. parasiticus on a number of agricultural commodities. This research was carried out to evaluate the ability of thermolysed and active Saccharomyces cerevisiae to attenuate liver damage caused by aflatoxin. Diets were prepared containing 0 aflatoxin; 400 mug kg-1 aflatoxin; 400 mug kg-1 aflatoxin plus 1% of dehydrated active yeast, and 400 mug kg-1 aflatoxin plus 1% of thermolysed yeast. A bioassay with Wistar rats was conducted for 28 days, and body organs were weighted and analyses of the liver tissue of the animals were performed. The relative weight of heart, kidneys and liver from animals submitted to the different treatments did not show any difference, and liver tissue of animals feeding on the aflatoxin-free diet was adopted as a toxicity-free pattern. Hepatic tissue of animals feeding on diets containing 400 mug kg-1 aflatoxin or the diet supplemented with 1% thermolysed yeast showed clear signs of toxicity and damage. Hepatic tissue of animals feeding on the diet containing 1% of dehydrated active yeast showed less toxicity signs and damage than those receiving the diet containing 400 mug kg-1 aflatoxin. Active, dehydrated yeast had the ability to reduce toxic effects caused by aflatoxin, but thermolysed yeast was not able to alleviate the effects of aflatoxin toxicity.As aflatoxinas são metabólitos hepatotóxicos produzidos por algumas linhagens de Aspergillus flavus, A. parasiticus e, eventualmente, por A. nomius sobre grande número de produtos agrícolas. Esta pesquisa foi conduzida para avaliar a capacidade de Saccharomyces cerevisiae, nas formas termolisada e desidratada viva, em reduzir os danos causados por aflatoxinas. Para tal, foi preparada uma dieta básica e desta se obtiveram quatro formulações: uma como controle; as demais contaminadas com aflatoxinas na concentração de 400 mig kg-1, sendo duas com posterior adição de 1% de leveduras, uma

  16. Discapacidad auditiva causada por citomegalovirus congénito (CMVc). Sintomatología, tratamiento y seguimiento desde el punto de vista de la Logopedia

    OpenAIRE

    2015-01-01

    La infección por citomegalovirus congénito es una de las infecciones más comunes de transmisión materno-fetal. Se trata de una de las principales etiologías de hipoacusia neurosensorial no genética, además de ser causa de otro tipo de patologías como parálisis cerebral, afectación visual o retraso psicomotor generalizado. Con este trabajo se pretende dar a conocer un poco más esta infección y las secuelas que puede causar para ayudar así a su prevención, diagnóstico precoz, seguimiento y trat...

  17. Obstrução das vias aéreas com risco para a vida, causada por edema de via aérea superior e inchaço cervical significativo depois do trabalho de parto/parto

    Directory of Open Access Journals (Sweden)

    Junko Ushiroda

    2013-12-01

    Full Text Available EXPERIÊNCIA E OBJETIVOS: Em geral, alterações nas vias aéreas ocorrem em grávidas normais; no entanto, essas alterações podem gerar situações críticas em populações específicas. OBJETIVOS: Esse artigo apresenta o caso de uma paciente que entrou em choque por causa de sangramento atônico em seguida a parto vaginal de natimorto. RELATO DE CASO: Mulher com 32 anos com sangramento atônico em seguida a parto vaginal de natimorto foi transferida para nosso hospital. A paciente manifestou choque e seu estado respiratório estava em progressiva deterioração. Ficou evidenciada obstrução das vias aéreas causada por inchaço cervical e edema faringolaríngeo. Tentamos intubação traqueal utilizando laringoscopia direta e indireta. No entanto, não foi possível inserir qualquer dos dispositivos de laringoscopia tentados. Depois de várias tentativas com TrachlightTM, finalmente obtivemos sucesso com a intubação. Depois da histerectomia, a paciente foi internada na unidade de terapia intensiva (UTI, onde ficou em tratamento durante cinco dias. Ao receber alta da UTI, tinha escore de Mallampati I-II. Durante sua estadia na UTI, seu peso diminuiu de 60 kg para 51 kg. CONCLUSÕES: É provável que episódios simultâneos de trabalho de parto/parto e de ressuscitação com fluidos pioraram suficientemente o edema de via aérea e o inchaço cervical a ponto de causar obstrução aguda das vias aéreas e dificuldade na laringoscopia.

  18. Tratamento das ulcerações traumáticas bucais causadas por aparelhos ortodônticos Treatment of the mouth traumatic ulcers caused by orthodontic appliances

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    Antonio Adilson Soares de Lima

    2005-10-01

    Full Text Available As lesões de aspecto ulcerado na mucosa bucal são um achado comum na clínica odontológica e geralmente são ocasionados por trauma mecânico devido a próteses mal adaptadas, aparelhos ortodônticos e dentes com coroas ou restaurações fraturadas. Contudo, os indivíduos nos quais a lesão persiste por mais de três semanas deverão ser submetidos à biopsia ou outros exames para excluir algumas lesões de caráter neoplásico ou outras condições, tais como as infecções crônicas e as doenças de caráter imunológico. Durante o tratamento ortodôntico, a dor e o desconforto da mucosa bucal podem acontecer como resultado do traumatismo mecânico dos aparelhos, ocasionado pela fricção aumentada entre o tecido da mucosa e a superfície dos braquetes. Atualmente, o ortodontista possui poucos recursos para prevenir ou aliviar esta irritação na mucosa. O objetivo deste artigo é orientar o ortodontista para o manejo mais adequado destas lesões visando o seu diagnóstico correto, o alívio dos sintomas que estas costumam provocar e o tratamento mais adequado para cada tipo de caso.Mouth ulcers are one of the most commom complaints in the dental clinic. They are, in general, caused for mechanic traumatism induced by non-fitted dentures, orthodontic appliances and fracturated crowns and fillings. Nevertheless, those lesions that have persisted for more than three weeks should be submitted to biopsy or other exams to exclude neoplasic, infectious or immunologic lesions. During the orthodontic treatment, pain and soreness of the oral mucosa can occur as the result of mechanic traumatism caused by increased friction between soft tissues and brackets. Nowadays, the professional owns few resources to prevention or relieve this irritation on the oral mucosa. The aim of this article is to guide the orthodontist to realize the correct diagnoses of the mouth ulcers, the relieve the symptoms and the exact treatment for each type of case.

  19. Papel dos medicamentos nas intoxicações causadas por agentes químicos em município da Bahia, no período de 2007 a 2010

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    Amanda dos Santos Teles

    2013-04-01

    Full Text Available A intoxicação medicamentosa é um problema de grande relevância para a saúde pública. No Brasil, os medicamentos são os principais agentes responsáveis por intoxicações humanas. Este artigo objetivou descrever o perfil e a evolução das intoxicações no município de Feira de Santana, Bahia, nos anos 2007 a 2010, e analisar a morbimortalidade causada por medicamentos. Neste estudo transversal, com caráter descritivo, foram analisados 631 casos registrados no SINAN. As variáveis utilizadas foram: sexo; faixa etária; raça; escolaridade; ocupação; evolução do caso notificado; zona de ocorrência da intoxicação; circunstância determinante para a ocorrência da intoxicação; tipo de exposição; frequência deste agravo; e tipo de unidade notificadora. Constatou-se que a intoxicação por medicamentos representou 33% das intoxicações, seguida de “raticidas” (18%, sendo a “tentativa de suicídio”, circunstância responsável, em 2010, por 81% das notificações. O sexo ‘feminino’ apresentou o maior número de casos registrados, bem como as crianças de 1 a 4 anos e os adultos jovens. A letalidade observada em Feira de Santana foi muito maior do que a média regional e nacional, excetuando-se o ano de 2009. A Vigilância em Saúde deve priorizar ações educativas, preventivas e intersetoriais, que assegurem o uso correto de medicamentos e melhorem seu impacto na saúde, bem como investir na sensibilização continuada dos profissionais da Atenção Básica para melhorar a notificação deste importante agravo.

  20. Mortality of the outbreak defoliator Ormiscodes amphimone (Lepidoptera: Saturniidae caused by natural enemies in northwestern Patagonia, Argentina Mortalidad del defoliador epidémico Ormiscodes amphimone (Lepidoptera: Saturniidae causada por enemigos naturales en el noroeste de la Patagonia Argentina

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    JUAN PARITSIS

    2012-03-01

    Full Text Available Outbreaks of the defoliator moth Ormiscodes amphimone are occurring more frequently in numerous Nothofagus forests of Patagonia. However, little is known about the life history of this species including its natural enemies as mortality agents. In this work we quantified mortality by parasitoids and generalist predators at the egg, larval and pupal life stages of O. amphimone in a Nothofagus pumilio (Poepp. & Endl. Krasser forest in northwestern Patagonia. Parasitism of eggs was relatively low (ca. 11 %, and we did not record significant larval predation by insectivorous birds. However, we recorded elevated mortality caused by larval parasitoids (ca. 50 % in third instar larvae and pupal predators (ca. 75 %, which suggests that these natural enemies could play a significant role in regulating O. amphimone populations. Our research is an initial step towards understanding the influence of natural enemies on O. amphimone population dynamics.Las irrupciones poblacionales de la polilla defoliadora Ormiscodes amphimone están ocurriendo de manera más frecuente en numerosos bosques de Nothofagus de la Patagonia. Sin embargo, se sabe poco de la historia natural de esta especie y, particularmente, de sus enemigos naturales. En este estudio se cuantificó la depredación de huevos, larvas y pupas de O. amphimone por parasitoides y otros depredadores en un bosque de Nothofagus pumilio (Poepp. & Endl. Krasser en el noroeste de la Patagonia. Se encontró que el parasitismo de huevos fue relativamente bajo (ca. 11 % y no se registró depredación significativa de larvas por aves insectívoras. No obstante, registramos niveles elevados de mortalidad causada por parasitoides de larvas (ca. 50 % en larvas en tercer instar y por depredadores de pupas (ca. 75 %, lo que parece indicar que estos enemigos naturales desempeñan un papel significativo en la regulación de poblaciones de O. amphimone. Este estudio representa un paso inicial hacia el entendimiento de la

  1. Anemia hemolítica causada por Ditaxis desertorum (Euphorbiaceae em bovinos Hemolytic anemia caused by Ditaxis desertorum (Euphorbiaceae in cattle

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    Carlos Hubinger Tokarnia

    1997-07-01

    Full Text Available Ditaxis desertorum Pax et K. Hoffm., planta herbácea da família Euphorbiaceae, causou experimentalmente em bovinos um quadro caracterizado por hemoglobinúria em virtude de sua ação hemolítica, quando administrada por via oral em doses diárias de 1,0 a 2,5 g/kg (planta fresca, a partir do 4° ao 8° dia do experimento. Após um período de 3 a 5 dias em que os animais tiveram hemoglobinúria e anemia acentuadas, apesar de continuarem a receber a planta (durante um total de 12 a 14 dias, em três dos quatro animais esses sintomas desapareceram. Verificou-se nesses casos uma rápida recuperação dos valores hemáticos logo que cessou a hemoglobinúria. O quarto bovino, que recebeu 2,5 g/kg/dia durante 5 dias, morreu no 8° dia, tendo apresentado durante os últimos 4 dias de vida hemoglobinúria e anemia acentuadas. À necropsia e nos exames histopatológicos deste animal foram verificadas nefrose hemoglobinúrica e distrofia hepática com necrose centrolobular do parênquima. Dose de 7,7 g/kg única ou quantidades de 2,5 e 3 g/kg/dia administradas durante 2 dias seguidos, causaram em três outros bovinos quadro clínico de cólica, com morte em questão de horas, verificando-se à necropsia acentuado edema da parede do rúmen e do retículo. Pelos históricos obtidos somente ocorre, sob condições naturais, a intoxicação caracterizada pelo quadro da anemia hemolítica, indicando que possivelmente a ingestão de D. desertorum em quantidades necessárias para causar o quadro com lesões dos proventrículos ser, apesar de sua boa palatabilidade, autolimitada pelo efeito cáustico da planta.Ditaxis desertorum Pax et K. Hoffm., a herbaceous plant of the Euphorbiaceae family, caused hemoglobinuria due to its hemolytic properties, when force-fed fresh to bovines in daily doses of 1.0 to 2.5 g/kg; the hemoglobinuria appeared from the 4th to 8th day of the experiment. After a period of 3 to 5 days of severe hemoglobinuria and anemia, these

  2. Espondilodiscite cervical espontânea causada por Salmonella typhi em paciente imunocompetente Immunocompetent patient with spontaneous cervical spondylodiscitis caused by Salmonella typhi

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    Asdrubal Falavigna

    2002-12-01

    Full Text Available Relatamos um caso de espondilodiscite cervical espontânea por Salmonella typhi. Trata-se de um paciente de 52 anos, hígido previamente, que procurou o serviço de neurocirurgia com queixa de dor na coluna cervical e região escapular. A investigação radiológica com cintilografia óssea e ressonância magnética sugeriram processo inflamatório dos corpos vertebrais de C5-C6 e do disco vertebral interposto. Houve crescimento da Salmonella typhi na hemocultura e no material obtido pela biópsia com agulha de C5 e aumento dos títulos séricos para Salmonella typhi. O tratamento instituído foi imobilização externa com halo-colete e antibioticoterapia com ciprofloxacina. Realizou-se revisão da literatura sobre aspectos clínicos, diagnósticos e terapêuticos dessa entidade de incidência incomun, principalmente pelo fato de acometer paciente imunocompetente e se localizar na região cervical da coluna vertebral.We report a case of spontaneous cervical spondylodiscitis caused by Salmonella typhi. A 52-year-old man presented in the neurosurgical service with complaints of pain in the cervical and scapular region. Cervical inflammatory disease was suggested by bone scintigraphy and magnetic resonance imaging. The diagnosis of Salmonella typhi spondylodiscitis was established by blood culture and culture of needle biopsy specimen taken from the C5 vertebra. The agglutinin titers for Salmonella were elevated. Intravenous ciprofloxacin therapy and external immobilization with a halo vest were instituted. A review of literature was performed evaluating the clinical, diagnostic and therapeutic aspects of this unusual pathology.

  3. Mejoramiento Genético de la Papa en Colombia, para Resistencia a la "Gota" Causada por el PhytophthoraInfestans, (Mont. de Bary

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    Estrada Ramos Nelson

    1954-06-01

    Full Text Available Se hace una revisión de la literatura más importante y reciente publicada en EE. UU., Inglaterra, Holanda, Alemania y Rusia, países que más sehan preocupado por resolver el problema del Phytophthora en la papa, y la relacionada especialmente con el aspecto de pérdidas que causa, razas del parásito, métodos genéticos para la obtención de variedades resistentes y sistemas de prueba de la resistencia. Además se incluyen datos estadísticos para demostrar la importancia del Cultivo en el país. Se indican los métodos seguidos en Colombia para el mejoramiento, partiendo especialmente de líneas de la especie silvestre. S. demíssumcombinándola con las variedades nativas cultivadas del tipo andigenumadaptadas a grandes alturas y a los días cortos de los trópicos. Los resultados hasta la fecha indican la posibilidad de obtener después de 3 ó4 generaciones de retrocruzamientos, una buena variedad para cultivo y altamente resistente a la enfermedad. También se aconseja el empleo de líneas y variedades extranjeras resistentes, una vez que se hayan probado a las razas de Phytophthorapropias de Colombia. . Se indica que ya existe material de fitomejoramiento bastante avanzado que es prácticamente inmune pero que requiere subsiguiente mejoramiento. Hay probabilidades así, de obtener variedades inmunes o altamente resistentes a las razas actualmente existentes aunque su identidad parece no corresponder exactamente con las de otros países como Holanda, Inglaterra y Estados Unidos. Se establece una falta de identidad entre las pruebas de campo y las del laboratorio aunque pueden complementarse. Puede suponerse, de acuerdo con las reacciones obtenidas en el material extranjero resistente, la posibilidad de existencia de varias razas, pero no tan virulentas como en los países que tienen variedades resistentes. Es aconsejable el mejoramiento permanente de las variedades, para poder combatir los nuevos biotipos del pat

  4. AVALIAÇÃO DE PERDAS CAUSADAS POR Oebalus spp. (HEMIPTERA: PENTATOMIDAE EM ARROZ DE TERRAS ALTAS EVALUATION OF UPLAND RICE LOSSES CAUSED BY Oebalus spp. (HEMIPTERA: PENTATOMIDAE

    Directory of Open Access Journals (Sweden)

    Daniela Rézio e Silva

    2007-09-01

    Full Text Available

    Para determinar o efeito dos percevejos Oebalus poecilus e O. ypsilongriseus sobre o rendimento e a qualidade dos grãos de arroz de terras altas, panículas de cinco cultivares foram infestadas, isoladamente, pelos seguintes níveis populacionais: zero (tratamento testemunha, dois insetos adultos da primeira espécie, dois insetos adultos da segunda espécie e um inseto adulto de cada espécie. A comparação das cultivares pelas porcentagens de perda de massa por espigueta e de espiguetas vazias não apresentou efeitos diferenciados entre tratamentos, nem interação "tratamentos x cultivares" significativa. A avaliação da atividade alimentar, pela presença de bainhas de estilete, mostrou que o percevejo O. ypsilongriseus foi mais ativo que O. poecilus. Esses afetaram de modo diferente o vigor das cultivares, entretanto, não influenciaram o teor de amilose. Os percevejos também reduziram o rendimento total de arroz beneficiado e aumentaram o número de grãos inteiros manchados, apesar de não terem alterado o número total de grãos inteiros.

    PALAVRAS-CHAVE: Inseto; percevejo das panículas; bainha de estilete.

    To determine the effect of Oebalus poecilus and O. ypsilongriseus on grain yield and quality of five upland rice cultivars, isolated panicles were subjected to four levels of infestation (number of adult insects: zero (control treatment, two O. poecilus, two O. ypsilongriseus and one O. poecilus plus one O. ypsilongriseus. Neither the treatments nor the interaction of the treatments with cultivars had significant effects on percentages of weight loss and empty spikelets. Insect activity, evaluated by the presence of feeding sheaths in the spikelets, demonstrated that O. ypsilongriseus was more active than O. poecilus. Plant vigor was also affected differently

  5. Genetic of uveitis.

    Science.gov (United States)

    Pichi, Francesco; Carrai, Paola; Srivastava, Sunil K; Lowder, Careen Y; Nucci, Paolo; Neri, Piergiorgio

    2016-06-01

    Immune-mediated uveitis may be associated with a systemic disease or may be localized to the eye. T-cell-dependent immunological events are increasingly being regarded as extremely important in the pathogenesis of uveitis. Several studies have also shown that macrophages are major effectors of tissue damage in uveitis. Uveitis phenotypes can differ substantially, and most uveitis diseases are considered polygenic with complex inheritance patterns. This review attempts to present the current state of knowledge from in vitro and in vivo research on the role of genetics in the development and clinical course of uveitis. A review of the literature in the PubMed, MEDLINE, and Cochrane databases was conducted to identify clinical trials, comparative studies, case series, and case reports describing host genetic factors as well as immune imbalance which contribute to the development of uveitis. The search was limited to primary reports published in English with human subjects from 1990 to the present, yielding 3590 manuscripts. In addition, referenced articles from the initial searches were hand searched to identify additional relevant reports. After title and abstract selection, duplicate elimination, and manual search, 55 papers were selected for analysis and reviewed by the authors for inclusion in this review. Studies have demonstrated associations between various genetic factors and the development and clinical course of intraocular inflammatory conditions. Genes involved included genes expressing interleukins, chemokines, chemokine receptors, and tumor necrosis factor and genes involved in complement system. When considering the genetics of uveitis, common threads can be identified. Genome-wide scans and other genetic methods are becoming increasingly successful in identifying genetic loci and candidate genes in many inflammatory disorders that have a uveitic component. It will be important to test these findings as uveitis-specific genetic factors. Therefore, the

  6. Juvenile arthritis and uveitis.

    Science.gov (United States)

    Kanski, J J

    1990-01-01

    The association between juvenile arthritis and uveitis is reviewed. Some children with the HLA-B27 related spondyloarthropathies develop anterior uveitis. About 20% of patients with juvenile rheumatoid arthritis (JRA) who are negative for IgM rheumatoid factor develop a frequently bilateral, nongranulomatous chronic anterior uveitis. Risk factors for uveitis in JRA patients are: female gender, pauciarticular onset of arthritis, presence of circulating antinuclear antibodies, and the antigens HLA-DW5 and HLA-DPw2. Uveitis is rare after seven years or more have elapsed from the onset of arthritis. The visual prognosis in patients with uveitis is good in 25% and fair in 50%. The remaining 25% develop visual impairment from complicated cataract and/or secondary inflammatory glaucoma. The potential benefit of cytotoxic agents in the treatment of intractable uveitis is outweighed by the risk of serious side effects. The management of secondary inflammatory glaucoma is unsatisfactory, but the results of treatment of complicated cataracts by lensectomy-vitrectomy are good.

  7. Mastite clinica caprina causada por Arcanobacterium pyogenes

    OpenAIRE

    Garino Jr,F.; R.A.T. Matos; Miranda Neto,E.G; Bernardino,J.N.N.; Santos,E.D.; Aguiar,G.M.N.

    2012-01-01

    This paper reports the occurrence of goat mastitis due to Arcanobacterium pyogenes in Paraiba State - Brazil. The diagnosis was confirmed by clinical symptoms and microbiological culture. Amastectomywasperformedasclinical treatment.

  8. Meningitis causada por staphylococcus aureus catalasa negativa

    OpenAIRE

    Álvarez Moreno, Carlos Arturo; Arroyo A., Claudia Patricia; Rodríguez, Elizabeth; Martínez R., Luz Marina; Quevedo S., Ruth

    2011-01-01

    En un paciente con cáncer se aisló del liquido cefaloraquideo y ascitico un coco gram positivo coagulasa positivo. El germen aislado mostró las características típicas de un Staphylococcus aureus, a excepción de la actividad de la catalasa, la cual no pudo ser encontrada.

  9. Avaliação lectino-histoquímica de fígado e rim de ovinos com fotossensibilização causada por Brachiaria decumbens

    Directory of Open Access Journals (Sweden)

    Samay Z.R. Costa

    2013-08-01

    Full Text Available Embora sejam as forrageiras mais importantes para a pecuária de corte (bovinocultura de corte no Brasil, em certas épocas ou condições, Brachiaria spp. podem ser tóxicas e causar surtos de fotossensibilização hepatógena que determinam significativas perdas econômicas. Animais que se alimentam em pastos de Brachiaria spp. comumente apresentam macrófagos espumosos isolados ou agrupados, além de cristais no interior de ductos biliares. Saponinas esteroidais têm sido identificadas nestes cristais e são responsabilizadas por lesar o fígado levando ao acúmulo de filoeritrina. Por vezes, imagens negativas desses cristais podem estar presentes no citoplasma de macrófagos espumosos. A patogênese de formação e o tipo de material armazenado nas células espumosas ainda são desconhecidos. A técnica de lectino-histoquímica visa auxiliar na detecção desses macrófagos e, consequentemente, no diagnóstico, além de identificar quais os resíduos de açúcares específicos que estão presentes no citoplasma das células espumosas. Assim, este trabalho teve por objetivo identificar quais lectinas são mais indicadas na detecção de saponinas esteroidais no fígado e rim de ovinos com fotossensibilização causada por Brachiaria decumbens. Fragmentos de fígado e rim de quinze ovinos, de ambos os sexos e idade variável, oriundos de Conceição do Mato Dentro, Minas Gerais, e um ovino mantido em pastagem livre de Brachiaria spp. foram avaliados pela técnica de lectino-histoquímica. Quatorze lectinas foram utilizadas (Con-A, DBA, SBA, PNA, SJA, RCA-I, UEA-I, WGA, SWGA, GSL, PSA, PHA-L, PHA-E e LCA. Verificou-se que, no fígado de ovinos com fotossensibilização provocada pela ingestão de Brachiaria decumbens, a lectina PNA apresentou especificidade e acentuada reatividade aos macrófagos espumosos, bem como especificidade e leve reatividade aos hepatócitos; a lectina WGA teve especificidade e moderada reatividade aos macr

  10. Infectious uveitis in Virginia

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    Engelhard SB

    2015-08-01

    Full Text Available Stephanie B Engelhard,1 Zeina Haddad,1 Asima Bajwa,1 James Patrie,2 Wenjun Xin,2 Ashvini K Reddy1 1Department of Ophthalmology, 2Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Purpose: To report the causes, clinical features, and outcomes of infectious uveitis in patients managed in a mid-Atlantic tertiary care center.Methods: Retrospective, observational study of infectious uveitis patients seen at the University of Virginia from 1984 to 2014.Results: Seventy-seven of 491 patients (15.7% were diagnosed with infectious uveitis (mean age 58 years, 71.4% female, 76.6% Caucasian. The mean follow-up was 5 years. Anterior uveitis was the most common anatomic classification (39 patients, 50.6% followed by panuveitis (20 patients, 26.0% and posterior uveitis (18 patients, 23.4%. The most common infectious etiology was herpetic anterior uveitis (37 patients, 48.1% followed by toxoplasma uveitis (14 patients, 18.2%. The most prevalent viral pathogen was varicella-zoster virus (21 patients, 27.3% followed by herpes simplex virus (20 patients, 26.0%. Acute retinal necrosis (ARN was diagnosed in 14 patients (18.2%. Aqueous humor yielded an etiologic diagnosis in seven (50% of ARN patients, four of whom tested positive for cytomegalovirus and three for varicella-zoster virus. On presentation, 43 patients (55.8% had a visual acuity (VA better than 20/40 and 17 (22.1% had a VA worse than 20/200. VA at the final follow-up was better than 20/40 in 39 patients (50.6% and worse than 20/200 in 22 patients (28.6%. In all, 16 (20.8% and 10 (13.0% patients required cataract and vitrectomy surgery, respectively. A total of 14 patients (18.2% were on glaucoma topical treatment and four (5.2% required glaucoma surgery.Conclusion: The most common type of infectious uveitis seen over the study period was herpetic anterior uveitis secondary to varicella-zoster virus or herpes simplex virus, found to be most prevalent in patients

  11. Desarrollo de una metodología para el estudio de las inundaciones causadas por encharcamiento de agua de lluvia en zonas urbanas relativamente planas. Area de estudio: Montería (Colombia

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    Padilla Agamez, Manuel

    2015-06-01

    Full Text Available In this paper a methodology for the analysis of the relationship between rainfall and flooding caused by ponding of rainfall water in urban area of Monteria (Colombia is developed. Rainfall water excesses over the soil were estimated from field measurements of the soil infiltration capacity for different soil units of the studied zone. The results obtained are presented in form of statistical correlations for calculating water rainfall excesses over the soils and maps of susceptibility and vulnerability for floods. The maps were used for a brief socioeconomic discussion of the effects of flood events in the selected zone.En el presente trabajo se desarrolla una metodología para el análisis de la relación existente entre las precipitaciones y las inundaciones causadas por encharcamiento de agua de lluvia en la zona urbana de Montería (Colombia. Se realizaron mediciones en campo de la capacidad de infiltración de agua para diferentes unidades de suelos de la zona de estudio, con el fin de estimar los excesos de agua de lluvia sobre el suelo. Los resultados obtenidos se presentan en forma de correlaciones estadísticas para el cálculo de los excesos de agua de lluvia y mapas de susceptibilidad y vulnerabilidad a las inundaciones, mediante los cuales se hace una breve discusión socioeconómica de los efectos de esta clase de inundaciones en la zona de estudio. [fr] Dans le présent travail est analysé la relation existant entre les précipitations et des inondations par accumulation d eau pluie sur le sol dans la zone urbaine de Montería (Colombie. Avec la réalisation de mesures en champ de la capacité d’infiltration pour différents unities de sol de la zone d’étude, on a estimé les excès d’eau pluie sur le sol. Les résultats obtenus sont présentés sous la forme de corrélations statistiques pour le calcul des excès d’eau pluie et de cartes de susceptibilité et vulnérabilité aux inondations. Les cartes ont été employ

  12. Infecções intramamárias causadas por Staphylococcus aureus e suas implicações em paúde pública Staphylococcus aureus intramammary infections and its implications in public health

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    Helena Fagundes

    2004-08-01

    Full Text Available Neste trabalho, são apresentados os principais problemas decorrentes das infecções intramamárias (mastites causadas por Staphylococcus aureus e as conseqüências para a saúde humana da veiculação de suas toxinas através do leite. o S. aureus destaca-se como um dos microorganismos mais importantes que podem ser transmitidos através dos alimentos. Assim, discute-se a possibilidade de veiculação de gastroenterite estafilocócica, não somente através do consumo de leite cru contaminado, mas também de leite tratado termicamente ou de derivados lácteos contendo enterotoxinas termoestáveis. São apresentados alguns aspectos relacionados ao potencial toxigênico das cepas de S. aureus, bem como as principais características das enterotoxinas estafilocócicas. Considerando que o S. aureus é um dos agentes de mastite mais freqüentemente observados, apresentam-se as principais medidas de controle de infecções estafilocócicas em rebanhos leiteiros, com vistas à prevenção da ocorrência de toxinas no leite de consumo.This article presents the main problems derived from the mammary infections (mastitis caused by Staphylococcus aureus, and the consequences of the presence of its toxins in milk for human health. S. aureus is one of the most important microorganisms that can be transmitted through the food products. Hence, the possibility of transmission of stafilococal gastroenteritis by consumption of raw milk and heat-treated milk, containing heat-resistant enterotoxins, is discussed. Some aspects regarding the toxigenic potential of S. aureus strains and the main characteristics of stafilococal entorotoxins are presented. Taking into account that S. aureus is also one of the most prevalent agents of mastitis, considerations are made on the methods for the controlling of stafilococal infections in dairy cattle, in order to prevent the occurrence of toxins in milk and milk products.

  13. Prevenção de injúrias causadas por glyphosate em soja RR por meio do uso de aminoácido Prevention of RR soybean injuries caused by exogenous supply of aminoacids

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    L.H.S. Zobiole

    2011-03-01

    Full Text Available A área de soja resistente ao glyphosate (RR tem aumentado a cada ano. No entanto, essa expansão com a tecnologia da soja RR aumentou o uso de glyphosate significativamente, e muitos agricultores têm notado que alguns cultivares RR apresentam injúrias visuais logo após a aplicação do glyphosate em pós-emergência. Dessa forma, dois experimentos foram instalados em anos distintos, com diferentes objetivos: o primeiro, visando avaliar a influência do glyphosate na soja RR nas variáveis fotossintéticas e de biomassa, e o segundo, a fim de reavaliar os mesmos parâmetros afetados na soja RR pelo glyphosate, bem como o uso de diversas modalidades de aplicação de aminoácidos como forma de uma provável recuperação das plantas de soja com sua utilização exógena. A taxa fotossintética e o índice SPAD apresentaram decréscimos proporcionais às doses de glyphosate aplicadas, sendo o efeito pronunciado com a aplicação única desse herbicida. Devido ao decréscimo da taxa fotossintética, à produção de clorofila e à provável imobilização de nutrientes nos tecidos foliares causada pelo glyphosate, foi observada menor produção de biomassa. Entretanto, o uso de aminoácidos exógenos amenizou os efeitos indesejáveis desse herbicida na cultura da soja RR.Glyphosate-resistant (RR soybean crop areas have expanded every year. However, as a result of this expansion, the use of glyphosate has significantly increased, with the appearance of visual injuries in RR soybeans immediately after post-emergence application of the herbicide. Thus, two experiments were conducted in different years with different objectives. The first experiment aimed to evaluate the influence of glyphosate on photosynthetic variables and biomass production. The second experiment aimed to re-evaluate the same parameters affected in RR soybeans by glyphosate, as well as the use of various methods of amino acid application, as a form of a likely recovery of the

  14. Estudo comparativo entre antlmoniato de meglumina, isotianato de pentamidina e sulfato de aminosidine, no tratamento de lesões cutâneas primárias causadas por Leishmania (viannia braziliensis

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    Dalmo Correia

    1996-10-01

    Full Text Available Com o objetivo de comparar a eficácia, a tolerabilidade e a toxicidade do antimoniato de meglumina, do sulfato de aminosidine e do isotianato depentamidine no tratamento de lesões cutâneas primárias causadas por Leishmania (Viannia braziliensis foi realizado um estudo de campo, aberto, randomizado, na área endêmica de Cone de Pedra-Bahia. De outubro de 1992 a janeiro de 1993, foram tratados 46 pacientes, distribuídos em três grupos dois de 15 e um de 16 pacientes. Todos os pacientes realizaram exames clínico, parasitológico, histopatológico e imunológico, como critério diagnóstico. Todos os pacientes foram tratados pela via intramuscular. O Grupo 1 recebeu pentamidina na dose de 4mg/k.g/dia, em dias alternados, no total de 8 aplicações; o Grupo 2 aminosidine na dose de 20mg/k.g/dia, por 20 dias; o Grupo 3, meglumina na dose de 10mg/kg/dia, por 20 dias. Definiu-se como falha terapêutica a permanência de lesões ulceradas, após quatro meses de tratamento. Ocorreram cinco casos de falha terapêutica assim distribuídos: dois casos no Grupo 1, um caso no Grupo 2 e dois no Grupo 3, ao final do primeiro ano de seguimento. Na avaliação após 3 anos foram revistos 15 pacientes, 5 em cada Grupo; exceto um do Grupo 3, todos continuaram curados. Não houve diferença estatística entre os resultados dos três esquemas utilizados.With the aim of comparing the therapeutic efficacy, tolerability and toxicity of meglumine antimoniate, aminosidine sulphate andpentamidine isethionate, a field study was conducted on randomized treatment of patients with primary cutaneous leishmaniasis due to Leishmania (Viannia braziliensis (L(Vb, in Cone de Pedra, BA, from October 1992 up to January 1993- Forty six patients were treated and distributed into three groups, two with 15 and one with 16 subjects. All patients were submitted to clinical examination, histopatological and immunological investigations, as diagnostic criterium. All patients were

  15. Aplicación tópica del Oleozón como alternativa de tratamiento en lesiones causadas por fricción en caballos de tiro; considerando algunos indicadores hematológicos

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    Ana María Camps-Ramírez| José Nabil Claro- González| Armando Cuesta- Guillén|

    2006-12-01

    Full Text Available El presente trabajo se realizó con una muestra de 75 animales de la raza mestiza pertenecientes a la UEB de transporte urbano en la iudad de San Germán; su edad promedio era de 8 años y la constitución corporal entre 3 y 4 conforme a la descripción de Henneke. Los mismos fueron ubicados en tres grupos de 25 animales cada uno; los que contaron con iguales condiciones de trabajo y alimentación. Se aplicó Oleozón, Violetas Gencianas o Aceite sin principio activo tomando en cuenta el grupo al que pertenecían (A, B, y C respectivamente.Esta investigación pudo determinar la efectividad del empleo tópico del Oleozón en heridas causadas por fricción en caballos de tiro. Los resultados obtenidos sobre este particular han sido comparados con losarrojados por otras dos pruebas simultáneas a la ejecución de este experimento conforme a una varianza triple y prueba múltiple de Duncan utilizando para ello el programa Stadistic versión 6.0 parap<0.05;mostrando diferencias significativas del Grupo A (tratado con Oleozón con respecto a los otros grupos tratados con los fármacos descritos anteriormente. Este trabajo mostró además los resultados delefecto del Oleozón sobre la sangre de los pacientes tratados; donde pudo comprobarse la acción inmunoestimulante de este fármaco, todo lo cual, puso en evidencia que el uso tópico del Oleozón en lesionescausadas por fricción en caballos de tiro reduce el tiempo de recuperación de los mismos, además de observarse que en elsitio de aplicación del Oleozón no se evidenció manifestación alguna AbstractThis work has been realized with a patten of 75 animals in the UEB of Urban Transportation in San German City. The average age was 8 years old and the corporal constitution between 3 and 4 according to the description of Henneke. They were located in three groups of 25animals and each group had egual conditions regarding work and feedingOleozón,Genciana Violet and Oil withourt active source was

  16. "efecto de un plástico fotoselectivo y de una pantalla climática en la enfermedad causada por el hongo botrytis cinerea pers. y en el negreamiento de los pétalos en un cultivo de rosas (rosahybrida)"

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    Rodríguez Ramírez, Aníbal; Arbeláez Torres, Germán

    2011-01-01

    El objetivo de la presente investigación fue comparar el comportamiento en postcosecha de la enfermedad causada por el hongo Botrytis cinerea Pers., así como el "negreamiento de los pétalos" en rosas cultivadas bajo invernaderos cubiertos con plásticos de diferente filtración de la luz ultravioleta. Adicionalmente, se evaluó el efecto de unapantalla climática sobre los dos problemas. El ensayo se realizó en el Centro de Investigaciones y Asesorías Agroindustriales, localizado en el municipio ...

  17. Seca dos ponteiros da goiabeira causada por Erwinia psidii: níveis de incidência e aspectos epidemiológicos Guava bacterial blight due to Erwinia psidii: incidence levels and epidemiological aspects

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    Abi Soares Anjos Marques

    2007-01-01

    Full Text Available Um dos fatores limitantes ao cultivo da goiabeira no Brasil é a 'seca dos ponteiros', causada por Erwinia psidii, presente nas regiões Sudeste e Centro-Oeste, onde se concentram grandes áreas produtoras. Considerando a pequena disponibilidade de informações sobre a epidemiologia e níveis de incidência dessa bacteriose, este estudo teve como objetivos: confirmar a distribuição e verificar a dispersão da seca dos ponteiros da goiabeira no Distrito Federal; investigar o efeito da temperatura sobre a multiplicação in vitro de E. psidii; desenvolver um teste de patogenicidade prático e eficiente e avaliar a sobrevivência in vitro da bactéria em diferentes substratos. A doença foi identificada em 56% das propriedades produtoras avaliadas no DF, com 81,9% de correlação entre a presença de sintomas e o diagnóstico laboratorial. A melhor faixa de temperatura para multiplicação de E. psidii foi de 24 a 33 ºC, e a bactéria permaneceu viável por até 120 dias em suspensão em água. A inoculação da bactéria em folhas ou hastes destacadas levou ao aparecimento de sintomas a partir do sétimo dia e mostrou-se eficiente como um teste rápido para se avaliar a patogenicidade de isolados.A major disease that affects guava is 'bacterial blight', caused by Erwinia psidii, which has been reported in Southeastern and Central Regions of Brazil where the major producing areas are located. Considering the lack of information on epidemiology and incidence levels of this disease, the objectives of this study were to confirm the presence and to verify the spread of the disease in Distrito Federal (DF; to determine optimal temperature for in vitro multiplication of E. psidii; to develop a simple and effective method for pathogenicity testing and to evaluate in vitro bacterial survival on different substrates. The disease was detected in 56% of producing orchards evaluated in DF, with a correlation of 81, 9% between presence of symptoms and

  18. Prevalência da filariose canina causada por Dirofilaria immitis e Dipetalonema reconditum em Maceió, Alagoas, Brasil Prevalence of canine filariasis by Dirofilaria immitis and Dipetalonema reconditum in Maceió, Alagoas State, Brazil

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    Ana Cristina Brito

    2001-12-01

    Full Text Available A prevalência da filariose canina causada por Dirofilaria immitis e Dipetalonema reconditum, foi estimada após a realização de inquérito hemoscópico em 1.519 cães domiciliados. Foram examinados 1.097 cães nos sete distritos sanitários da cidade de Maceió, Alagoas, 204 na Ilha de Santa Rita e 218 na cidade de Paripueira. Em Maceió, foram detectados 15 (1,3% cães com microfilárias (MF de D. immitis e 15 (1,3% com MF de D. reconditum. Todos os casos positivos foram considerados autóctones. As MF de D. immitis e de D. reconditum mediram 298,1µm e 249,2µm de comprimento e 7,3µm e 4,4µm de largura, respectivamente. Além do diagnóstico parasitológico pela técnica de gota espessa (100µL, foi utilizado o teste imunológico Witness, para detecção de antígeno filarial circulante, o qual confirmou os dados parasitológicos e permitiu a detecção de casos de infecção oculta. De um total de 6.579 fêmeas examinadas, pertencentes a seis espécies de mosquitos, oito (0,1% fêmeas de Culex quinquefasciatus foram encontradas naturalmente infectadas com larvas de D. immitis. Estes resultados demonstram a presença simultânea de D. immitis e D. reconditum na mesma área geográfica.A survey on the prevalence of Dirofilaria immitis and Dipetalonema reconditum was conducted in 1,519 dogs from Maceió and two coastal areas in the State of Alagoas, Northeast Brazil, from 1995 to 1999, by testing for microfilariae in blood. All blood samples were from exclusively domiciled dogs with a known history, showing that the infections were autochthonous, confirming transmission of canine filariasis in these areas. In Greater Metropolitan Maceió, 15 (1.3% microfilaremic dogs were detected with D. immitis and 15 (1,3% with D. reconditum. In the southern coastal area there was an estimated prevalence of 12.7% for D. immitis. D. immitis and D. reconditum microfilaria were 298.1µm and 249.2µm long and 7.3µm and 4.4µm wide, respectively. A Witness

  19. Cerebral aspergillosis due to Aspergillus fumigatus in AIDS patient: first culture - proven case reported in Brazil Aspergilosis cerebral causada por Aspergillus fumigatus en paciente con SIDA: primer reporte de caso demostrado por cultivo en Brasil

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    José E. Vidal

    2005-06-01

    Full Text Available Cerebral aspergillosis is a rare cause of brain expansive lesion in AIDS patients. We report the first culture-proven case of brain abscess due to Aspergillus fumigatus in a Brazilian AIDS patient. The patient, a 26 year-old male with human immunodeficiency virus (HIV infection and history of pulmonary tuberculosis and cerebral toxoplasmosis, had fever, cough, dyspnea, and two episodes of seizures. The brain computerized tomography (CT showed a bi-parietal and parasagittal hypodense lesion with peripheral enhancement, and significant mass effect. There was started anti-Toxoplasma treatment. Three weeks later, the patient presented mental confusion, and a new brain CT evidenced increase in the lesion. He underwent brain biopsy, draining 10 mL of purulent material. The direct mycological examination revealed septated and hyaline hyphae. There was started amphotericin B deoxycholate. The culture of the material demonstrated presence of the Aspergillus fumigatus. The following two months, the patient was submitted to three surgeries, with insertion of drainage catheter and administration of amphotericin B intralesional. Three months after hospital admission, his neurological condition suffered discrete changes. However, he died due to intrahospital pneumonia. Brain abscess caused by Aspergillus fumigatus must be considered in the differential diagnosis of the brain expansive lesions in AIDS patients in Brazil.La aspergilosis cerebral es una causa rara de lesión expansiva cerebral en pacientes con SIDA. Presentamos el primer reporte de un absceso cerebral causado por Aspergillus fumigatus en un paciente brasileño con SIDA. El paciente, de 26 años de edad, presentaba antecedentes de infección por el virus de la inmunodeficiencia humana (VIH, tuberculosis pulmonar y toxoplasmosis cerebral. Manifestó fiebre, tos, disnea y dos episódios de convulsiones. La tomografía computadorizada (TC demostró una lesión hipodensa parasagital y bi-parietal con

  20. Mortalidad por bacteriemia causada por Escherichia coli y Klebsiella spp. productoras de beta lactamasas de espectro extendido: cohorte retrospectiva en un hospital de Lima, Perú Mortality caused by bacteremia Escherichia coli and Klebsiella spp. extended-spectrum beta-lactamase- producers: a retrospective cohort from a hospital in Lima, Peru

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    Diego Adrianzén

    2013-03-01

    Full Text Available Objetivos. Evaluar los factores asociados a la mortalidad causada por bacteriemias por Escherichia coli y Klebsiella spp. productoras de beta lactamasas de espectro extendido (BLEE. Materiales y Métodos. Se realizó un estudio de cohortes retrospectivo, que incluyó 85 pacientes mayores de 16 años con diagnóstico de bacteriemia por Escherichia coli o Klebsiella spp. hospitalizados entre 2006 y 2008 en el Hospital Nacional Cayetano Heredia. Las cohortes se clasificaron de acuerdo a la producción de BLEE según los resultados de los hemocultivos. Se evaluaron los factores asociados a la mortalidad cruda y atribuible empleando regresión de Poisson en un modelo multivariado, con lo que se obtuvo riesgos relativos ajustados (RRa. Además, se construyeron curvas de mortalidad. Resultados. Se encontró que el 35,3% de las bacteriemias fueron debidas a cepas productoras de BLEE. El análisis de la mortalidad cruda mostró una mayor mortalidad en el grupo de cepas productoras de BLEE (63,3%. El RRa fue de 1,5 (IC95%: 1,02-2,3. En el caso de mortalidad atribuible, la proporción también fue mayor (63,3%, el RRa fue de 1,9 (IC95%: 1,2-2,9. El uso de catéter venoso central fue otro factor asociado tanto a la mortalidad cruda (RRa= 2,4; IC95%: 1,2- 4,8 como a la mortalidad atribuible (RRa= 3,8; IC95%: 1,6-8,8. Conclusiones. La producción de BLEE es un factor de riesgo independiente para mortalidad por bacteriemia causada por E. coli y Klebsiella spp. Su presencia debe evaluarse tras la sospecha diagnóstica y la elaboración de la terapéutica inicial, lo que podría disminuir la mortalidad por esta causaObjectives. To evaluate the factors associated to mortality caused by bacteremia due to Escherichia coli and Klebsiella spp. producers of extended-spectrum beta-lactamase (ESBL. Materials and methods. We performed a retrospective cohort study, including 85 patients older than 16 and diagnosed with bacteremia by Escherichia coli or Klebsiella spp

  1. INFECTIOUS KERATOCONJUNTIVITIS OUTBREAK IN OVINES DUE TO Moraxella spp IN STATE OF GOIÁS, BRAZIL SURTO DE CERATOCONJUNTIVITE INFECCIOSA EM OVINOS CAUSADA POR Moraxella spp. NO ESTADO DE GOIÁS, BRASIL

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    Nilo Sérgio Troncoso Chaves

    2008-04-01

    ','serif'">Moraxella spp foi feito por meio de cultura nos Laboratórios de Microbiologia do Centro de Pesquisa de Alimentos da Escola de Veterinária da Universidade Federal de Goiás (APA/EV-UFG e do Departamento de Medicina Veterinária da Escola de Veterinária da Universidade Federal de Goiás (DMV/EV-UFG. O controle do foco na propriedade envolveu os protocolos: 1. higiênico, com o isolamento em ambiente de pouca luminosidade, repouso e alimentação adequada;  2. medicamentoso, mediante o uso de solução fisiológica 0,9% para a lavagem dos olhos, pomada oftálmica de cloridrato de oxitetraciclina para uso local e cloridrato de oxitetraciclina LA injetável, tanto para os animais doentes como para o restante do rebanho;  3. profilático, por meio de vacina comercial contra a ceratoconjuntive infeciosa e combate às moscas. A recuperação da maioria dos animais minimizou as perdas econômicas e evitou a disseminação da enfermidade na propriedade e para outras fazendas. No Brasil, existem poucos estudos a respeito de surtos de CCI em ovinos, o que motivou a realização deste trabalho, diante da escassez de informações sobre essa doença ocular, causada pela Moraxella spp, em ovinos, no estado de Goiás, Brasil

  2. Equine recurrent uveitis--a spontaneous horse model of uveitis.

    Science.gov (United States)

    Deeg, Cornelia A; Hauck, Stefanie M; Amann, Barbara; Pompetzki, Dirk; Altmann, Frank; Raith, Albert; Schmalzl, Thomas; Stangassinger, Manfred; Ueffing, Marius

    2008-01-01

    Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody-binding pattern of horses affected by spontaneous recurrent uveitis (ERU) to the retinal proteome. CRALBP also seems to be relevant to human autoimmune uveitis. Proteomic screening of vitreous and retinal samples from ERU diseased cases in comparison to healthy controls has led to the identification of a series of differentially regulated proteins, which are functionally linked to the immune system and the maintenance of the blood-retinal barrier.

  3. Cytomegalovirus and other herpesviruses infections in heart and bone marrow transplant recipients Infecções causadas por citomegalovírus e outros vírus do grupo herpes em transplantados cardíacos e de medula óssea

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    Adriana Weinberg

    1990-10-01

    Full Text Available From January 1988 to January 1989 all the heart transplant and bone marrow recipients at the Instituto do Coração of the Hospital das Clínicas of the University of São Paulo Medical School were studied for the incidence and morbidity associated with herpesviruses infections after transplantation. Five bone marrow and 5 heart transplant recipients were followed for a mean of 4.2 months post-transplantation. All the patients were seropositive for cytomegalovirus (CMV before admission and 80% experienced one or more recurrences during the observation period. Of the 12 episodes of CMV infection, that were identified in this study, 83% were accompanied by clinical or laboratory abnormalities. However, there was only one case of severe disease. The overall incidence of infection for herpes simplex (HSV was 50%. Although most of HSV reactivations were oral or genital, one case of HSV hepatitis occurred. One of the 6 episodes of HSV infections that were treated with acyclovir showed an unsatisfactory response and was successfully managed with ganciclovir. All the individuals had anti-varicella zoster virus antibodies, but none of them developed infection. The study emphasizes the importance of active diagnostic surveillance of herpesvirus infections in transplant patients. Both CMV and HSV reactivations showed high incidence and important morbidity and thus, deserve prophylactic therapy.De janeiro de 1988 a janeiro de 1989 todos os pacientes submetidos a transplante de coração ou de medula óssea no Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo foram estudados quanto à incidência e morbidade das infecções pós-transplante causadas por vírus do grupo herpes. Cinco recipientes de medula óssea e 5 transplantados cardíacos foram observados por um período médio de 4.2 meses após o transplante. Todos os pacientes tinham sorologia positiva para citomegalovírus (CMV antes do transplante

  4. Uveitis in juvenile chronic arthritis.

    Science.gov (United States)

    Kanski, J J

    1990-01-01

    About 20% of patients with juvenile chronic arthritis develop uveitis which is frequently bilateral. Risk factors for uveitis are: female gender, pauciarticular onset of arthritis, presence of circulating antinuclear antibodies, and the antigens HLA-DW5 and HLA-DPw2. The visual prognosis in patients with uveitis is good in 25% and fair in 50%. The remaining 25% develop cataract and/or glaucoma. The management of glaucoma is unsatisfactory, but the results of cataract surgery by lensectomy are good.

  5. Redução na produção da soja causada por Bemisia tabaci (Gennadius) biótipo b (Hemiptera: Aleyrodidae) e avaliação de táticas de controle

    OpenAIRE

    Simone Silva Vieira

    2009-01-01

    Objetivou-se com este trabalho estimar a redução na produção de soja causada pela mosca branca e estudar táticas de controle para seu manejo. Os experimentos foram conduzidos em casa de vegetação e área de campo da Embrapa Arroz e feijão e em lavouras de Itauçú e Goiânia, GO. O nível de controle foi avaliado a campo em três níveis de infestação com testemunha sem infestação. Semanalmente contou-se o numero de ninfas/folíolo e no final do ciclo avaliou-se a produção e o peso de ...

  6. Uveitis in childhood : clinical and fundamental developments

    NARCIS (Netherlands)

    Kalinina Ayuso, V.

    2013-01-01

    This thesis aimed to gain new insights regarding the course and prognosis of uveitis in childhood, the pathogenesis of JIA-uveitis and the treatment of uveitis in children. The role of baseline prognostic factors in JIA-uveitis was studied by a retrospective analysis of 117 affected eyes of 65 patie

  7. Uveitis and Gender: The Course of Uveitis in Pregnancy

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    Nathalie P. Y. Chiam

    2014-01-01

    Full Text Available The hormonal and immunological changes in pregnancy have a key role in maintaining maternal tolerance of the semiallogeneic foetus. These pregnancy-associated changes may also influence the course of maternal autoimmune diseases. Noninfectious uveitis tends to improve during pregnancy. Specifically, uveitis activity tends to ameliorate from the second trimester onwards, with the third trimester being associated with the lowest disease activity. The mechanism behind this phenomenon is likely to be multifactorial and complex. Possible mechanisms include Th1/Th2 immunomodulation, regulatory T-cell phenotype plasticity, and immunosuppressive cytokines. This clearly has management implications for patients with chronic sight threatening disease requiring systemic treatment, as most medications are not recommended during pregnancy due to lack of safety data or proven teratogenicity. Given that uveitis activity is expected to decrease in pregnancy, systemic immunosuppressants could be tapered during pregnancy in these patients, with flare-ups being managed with local corticosteroids till delivery. In the postpartum period, as uveitis activity is expected to rebound, patients should be reviewed closely and systemic medications recommenced, depending on uveitis activity and the patient’s breastfeeding status. This review highlights the current understanding of the course of uveitis in pregnancy and its management to help guide clinicians in managing their uveitis patients during this special time in life.

  8. Uveitis: the collaborative diagnostic evaluation.

    Science.gov (United States)

    Harman, Lynn E; Margo, Curtis E; Roetzheim, Richard G

    2014-11-15

    Uveitis, or inflammation of the uveal tract (i.e., iris, ciliary body, and choroid), results from a heterogeneous collection of disorders of varying etiologies and pathogenic mechanisms. Uveitis is caused by a systemic disease in 30% to 45% of patients. Primary care physicians may be asked to evaluate patients with uveitis when an underlying systemic diagnosis is suspected but not apparent from eye examination or history. If the history, physical examination, and basic laboratory studies do not suggest an underlying cause, serologic tests for syphilis and chest radiography for sarcoidosis and tuberculosis are recommended. Typing for human leukocyte antigen-B27 is appropriate for patients with recurrent anterior uveitis. Because the prevalence of many rheumatologic and infectious diseases is low among persons with uveitis, Lyme serology, antinuclear antibody tests, serum angiotensin-converting enzyme tests, serum lysozyme tests, and tuberculin skin tests can result in false-positive results and are not routinely recommended. Drug-induced uveitis is rare and can occur from days to months after the time of initial exposure. Primary ocular lymphoma should be considered in persons older than 50 years with persistent intermediate or posterior uveitis that does not respond to anti-inflammatory therapy.

  9. Magnetic resonance imaging of uveitis

    Energy Technology Data Exchange (ETDEWEB)

    Li, Charles Q.; Mafee, Mahmood F. [University of California, San Diego, Department of Radiology, San Diego, CA (United States); Cho, Aaron A. [Naval Medical Center, San Diego, CA (United States); Edward, Neeraj J. [University of Cincinnati, Department of Anesthesiology, Cincinnati, OH (United States); Edward, Deepak P. [King Khaled Eye Specialist Hospital, Riyadh (Saudi Arabia); Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD (United States); Fajardo, Roman G. [University of California, San Diego, Shiley Eye Center, La Jolla, CA (United States)

    2015-08-15

    Uveitis is a term used to describe inflammation of the choroid, iris, or ciliary body, which make up the uveal tract. It can be idiopathic or associated with a systemic disease which may be infectious or noninfectious. With the exception of B-scan ultrasonography, current imaging methods for diagnosing and monitoring uveitis are predominately non-radiologic. Although MRI has been anecdotally shown to detect various inflammatory conditions of the globe, such as posterior scleritis, endophthalmitis, and posterior uveitis secondary to Vogt-Koyanagi-Harada disease, a more comprehensive review of the MRI findings in uveitis of various etiologies is presented here. The MRI and CT studies of seven patients with uveitis and the clinical history of three of them (not available in four patients) were reviewed. Etiologies included ankylosing spondylitis, relapsing polychondritis, Vogt-Koyanagi-Harada disease, sarcoidosis, and tuberculosis. Increased gadolinium enhancement of the uveal tract, which is visualized as the enhancing layer immediately deep to the low-signal sclera, was seen on all six MRI studies. Diffusion-weighted imaging of a case with posterior uveitis and subretinal effusions revealed restriction within the uvea and effusions. Two patients had inflammatory nodules adherent to the uvea, two patients had vitreous humor abnormalities, and one patient exhibited proximal perineural and perimuscular spread of enhancement. Uveoscleral thickening and enhancement with a posterior calcification were observed in the patient with chronic uveitis imaged with CT. Increased uveal tract enhancement is a common finding in patients with uveitis, regardless of anatomic distribution and etiology. MRI can also further evaluate complications of uveitis and help differentiate it from masquerade syndromes. (orig.)

  10. Contaminación acústica causada por el transporte transpirenaico en el País Vasco y Cataluña: una aproximación estadística – Proyecto TransP1

    OpenAIRE

    Amo Sanz, Diego

    2016-01-01

    En este proyecto fin de carrera se propone el estudio de las principales rutas transpirenaicas a su paso por Navarra y Cataluña mediante el análisis mediante una encuesta de la contaminación, tanto acústica como debida a gases de combustión en el escape, que emiten los vehículos a su paso por ellas. Me centraré en la contaminación acústica sufrida por los vecinos de las zonas objeto del estudio, ya que son las 2 zonas por las que principalmente se cruza la frontera hacia Francia. Más del 85% ...

  11. Ocorrência de nova doença do algodoeiro irrigado, no Brasil, causada por Sclerotinia sclerotiorum Occurrence of a new disease of irrigated cotton, in Brazil, caused by Sclerotinia sclerotiorum

    Directory of Open Access Journals (Sweden)

    Maria José D´avila Charchar

    1999-06-01

    Full Text Available Em 1996, uma nova doença causada pelo fungo Sclerotinia sclerotiorum (Lib. de Bary foi observada em algodoeiro (Gossypium hirsutum L., cultivar Deltapine, irrigado sob pivô central, em Paracatu, MG. Os sintomas apresentados foram murcha e podridão da haste, do pecíolo da folha e da maçã, além de serem observados no interior do capulho micélio branco e escleródios escuros do patógeno. O teste de patogenicidade foi efetuado em algodoeiro, nas cultivares Deltapine e IAC 22, e em feijoeiro e quiabeiro, aos 14 dias de idade. As plantas foram incubadas em alta umidade durante 48 horas, a 25ºC. Três dias após a inoculação, verificaram-se sintomas severos de murcha e necrose dos tecidos, de onde o patógeno foi reisolado, completando-se, assim, os postulados de Koch. Este é o primeiro relato da ocorrência natural de S. sclerotiorum em algodoeiro no Brasil.In 1996, a new disease caused by Sclerotinia sclerotiorum (Lib. de Bary was observed on cotton (Gossypium hirsutum L. Deltapine cultivar irrigated under central pivot at Paracatu, MG, in the Savana region of Central Brazil. The symptoms were wilt, necrosis and rot. White mycelium and black sclerotia developed inside the boll. The pathogenicity test was done with two-week old cotton seedling cultivars Deltapine and IAC 22 and bean and okra seedlings. The plants were incubated at high humidity for 48 hours at 25ºC. Three days after inoculation, severe symptoms of wilt and necrosis were observed. S. sclerotiorum was reisolated from the damaged plant tissues, and Koch´s postulates were completed. This is the first report of S. sclerotiorum natural occurrence on cotton in Brazil.

  12. Emergent infectious uveitis

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    Khairallah Moncef

    2009-01-01

    Full Text Available Infectious causes should always be considered in all patients with uveitis and it should be ruled out first. The differential diagnosis includes multiple well-known diseases including herpes, syphilis, toxoplasmosis, tuberculosis, bartonellosis, Lyme disease, and others. However, clinicians should be aware of emerging infectious agents as potential causes of systemic illness and also intraocular inflammation. Air travel, immigration, and globalization of business have overturned traditional pattern of geographic distribution of infectious diseases, and therefore one should work locally but think globally, though it is not possible always. This review recapitulates the systemic and ocular mainfestations of several emergent infectious diseases relevant to the ophthalmologist including Rickettsioses, West Nile virus infection, Rift valley fever, dengue fever, and chikungunya. Retinitis, chorioretinitis, retinal vasculitis, and optic nerve involvement have been associated with these emergent infectious diseases. The diagnosis of any of these infections is usually based on pattern of uveitis, systemic symptoms and signs, and specific epidemiological data and confirmed by detection of specific antibody in serum. A systematic ocular examination, showing fairly typical fundus findings, may help in establishing an early clinical diagnosis, which allows prompt, appropriate management.

  13. Uveitis and Gender: The Course of Uveitis in Pregnancy

    OpenAIRE

    Chiam, Nathalie P. Y.; Lim, Lyndell L. P.

    2014-01-01

    The hormonal and immunological changes in pregnancy have a key role in maintaining maternal tolerance of the semiallogeneic foetus. These pregnancy-associated changes may also influence the course of maternal autoimmune diseases. Noninfectious uveitis tends to improve during pregnancy. Specifically, uveitis activity tends to ameliorate from the second trimester onwards, with the third trimester being associated with the lowest disease activity. The mechanism behind this phenomenon is likely t...

  14. Patrón de alteraciones en la radiografía de tórax de niños hospitalizados por infección causada por virus influenza A (H1N1 Pattern of chest radiographic abnormalities in children hospitalized because of influenza H1N1 virus infection

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    KARLA MOËNNE B

    2010-09-01

    Full Text Available El año 2009 aparecieron los primeros casos de influenza humana causada por virus influenza A H1N1, propagándose como pandemia. En nuestra institución se observó 88,5% de aumento en consultas de urgencia, adultos y niños; se diagnosticaron 10.048 pacientes como influenza A H1N1 (45,6% confirmación de laboratorio. La media de edad fue 13 años. Se hospitalizaron 59 niños (edad: 1 mes - 15 años 7 meses, 33 niñas y 26 niños. El tiempo promedio de hospitalización fue de 3,9 días; 9 pacientes requirieron UTIy 4 ventilación mecánica. No hubo mortalidad en esta serie. Se demostró sobreinfección por VRS (5, infección bacteriana (9 y Mycoplasma (1. El patrón radiológico predominante en los niños hospitalizados correspondió a compromiso intersticial (72% y el 28% presentó hiperinsuflación pulmonar. Los niños con infección bacteriana asociada presentaron mayoritariamente (78% patrones radiológicos mixtos y de relleno alveolar. El propósito de esta revisión es conocer los patrones radiológicos en los niños que requirieron hospitalización por infección virus influenza A H1N1 en nuestra institución, durante la epidemia del año recién pasado.The first cases of H1N1- type Influenza virus infection in humans were reported in 2009, and since then, it rapidly expanded and became pandemic. At that time, an 88.5% increase in emergency consultations was observed in our institution, including adults and children and H1N1- type Influenza virus infection was clinically diagnosed in 10,048patients, 45.6% of them with laboratory confirmation. A total of 59 child, 33 girls and 26 boys, aged between 1 month and 15.5 years old, needed hospitalization. The average of hospitalization time was 3.9 days, 9 patients required intensive unit care and 4 of them mechanical ventilation. No fatal cases were registered in this series. Associated infection was confirmed in 15 patients: VRS (5, bacterial (9 and Mycoplasma (1. The most frequent

  15. Herencia Genética y Citoplásmica de la Resistencia a la Pudrición de la Mazorca del Maíz (Zea mays L.) Causada por Fusarium moniliforme Sheld

    OpenAIRE

    Mariano Mendoza; Alfonso López; Arnoldo Oyervides; Gaspar Martínez; Carlos León; Ernesto Moreno

    2003-01-01

    La resistencia genética ofrece el más amplio potencial para el control de la resistencia a la pudrición de mazorca y tallo de maíz causado por Fusarium moniliforme, el cual tiene una distribución cosmopolita y afecta la calidad del grano y tallos de plantas afectadas. Además, es una amenaza para la salud del hombre y los animales por la producción de toxinas cancerígenas. Por lo anterior, se propuso como objetivo determinar la aptitud combinatoria general (ACG), la aptitud combinatoria espec...

  16. Causes of Red Eye-Uveitis

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    Selçuk Sızmaz

    2012-12-01

    Full Text Available Uveitis, being an important cause of ocular morbidity, must be taken into consideration in the differential diagnosis and the management of patients with red eye. Uveitis entities can demonstrate variable clinical features. Patients presenting with uveitis must undergo careful systemic evaluation for exact diagnosis and treatment. Studies for standardization of uveitis with variable clinical pictures are emerging. Acute anterior uveitis and panuveitis can cause red eye. The purpose of this current study is to summarize the clinical features and laboratory investigations that could help the differential diagnosis of acute anterior uveitis and panuveitis cases. (Turk J Ophthalmol 2012; 42: Supplement 57-62

  17. Lesiones histológicas en músculo esquelético, causadas por larvas de Eustrongylides sp (Nematoda: Dictophymatidae) en ranas comestibles del Lago Cuitzeo, Michoacán, México

    OpenAIRE

    José Ramírez Lezama; David Osorio Sarabia

    2002-01-01

    El presente estudio tiene como objetivo informar sobre las lesiones microscópicas provocadas por larvas de Eustrongylides sp en músculo esquelético de ranas en el Lago Cuitzeo, Michoacán, México, considerado un parásito potencialmente zoonótico. Se revisaron 146 ejemplares de las cuatro especies: 80 de Rana megapoda, 43 de Rana dunni, 16 de Rana catesbiana y siete de Rana verlandieri, a los cuales se le aplicó la eutanasia con sobredosis de pentobarbital por vía intraperitoneal. Se registró e...

  18. Síndrome do ápice orbitário causada por herpes zóster oftálmico: relato de caso e revisão da literatura Herpes zoster ophthalmicus and orbital apex syndrome: case report and literature review

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    Kenzo Hokazono

    2009-10-01

    Full Text Available OHerpes Zoster Oftálmico (HZO decorre da infecção pelo vírus da varicela-zoster que permanece latente no gânglio de Gasser até que seja reativado e comprometa a divisão oftálmica do nervo trigêmeo. HZO freqüentemente causa manifestações oftalmológicas como lesões vesiculares palpebrais, ceratoconjuntivite, esclerite, uveíte, paralisia oculomotora, miosite orbitária e neurite óptica. Raramente o acometimento do ápice da órbita pode ser a manifestação inicial desta grave afecção. Este trabalho relata um caso de síndrome do ápice orbitário associado à meningite, causado por HZO e que foi tratado com corticosteróide e aciclovir sistêmicos.Herpes Zoster ophthalmicus (HZO is caused by a varicella-zoster virus infection which remains latent in the ganglion of Gasser until it is reactivated and compromise the ophthalmic division of the trigeminal nerve. HZO commonly causes neuro-ophthalmic complications such as vesicular lesions in the eyelids, keratoconjunctivitis, sclertis, uveitis, ocular palsy, orbital miositis and optic neuritis. HZO rarely presents as an orbital apex syndrome. This paper describes a patient with of orbital apex syndrome associate and meningitis caused by HZO which was treated with systemic steroids and acyclovir.

  19. Erlotinib-related bilateral anterior uveitis

    Science.gov (United States)

    Ali, Kashif; Kumar, Indu; Usman-Saeed, Muniba; Usman Saeed, Muhammad

    2011-01-01

    The authors report the case of a 68-year-old woman with secondary adenocarcinoma of the lungs from an unknown primary. Erlotinib was started which produced symptoms suggestive of uveitis. Erlotinib was stopped and restarted a month later at a lower dose, which resulted in severe bilateral anterior uveitis. The uveitis settled after stopping erlotinib and treatment with topical steroids and cycloplegics. To the best of the authors’ knowledge, this is the first case of erlotinib-related anterior uveitis. PMID:22694887

  20. Estimativas de perdas econômicas causadas por reação granulomatosa local após uso de vacina oleosa contra febre aftosa em bovinos de Mato Grosso do Sul

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    Paula V. Leal

    2014-08-01

    Full Text Available Lesões exacerbadas à vacina contra a febre aftosa foram observadas em 1.815 de um total de 5.000 bovinos abatidos em frigorífico com inspeção federal. Essas lesões resultaram na condenação de parte das carcaças de acordo com o Regulamento da Inspeção Industrial e Sanitária de Produtos de Origem Animal. Os bovinos haviam sido vacinados em maio de 2012 e abatidos em setembro do mesmo ano e divididos em Lotes 1 e 2 constituídos respectivamente por 1.500 e 315 bovinos. As lesões de reação vacinal eram caracterizadas por nódulos protuberantes, circunscritos, bem delimitados, firmes e de tamanhos variáveis, distribuídos multifocalmente na musculatura do aspecto lateral do pescoço; ao corte apresentavam exsudato purulento. Amostras da lesão de 28 bovinos foram avaliadas histologicamente e os principais achados foram piogranulomas com espaços claros circulares de tamanhos variados no centro, circundados por intenso infiltrado de neutrófilos íntegros e necróticos, circundados por macrófagos epitelioides com citoplasma vacuolizado, ocasionais células gigantes multinucleadas e, mais externamente, por abundante tecido conjuntivo em meio observavam-se linfócitos e plasmócitos. Culturas bacterianas realizadas em amostras do exsudato da lesão de seis bovinos resultaram negativas. Quando as carcaças afetadas foram submetidas ao toalete foi retirado em média 1,8 e 2,0 kg de músculo da área afetada, respectivamente dos Lotes 1 e 2. O prejuízo econômico da propriedade de origem dos bovinos afetados foi de R$ 20.424,00, considerando o preço pago pela arroba do boi no mês e ano da ocorrência. Esses valores à época seriam suficientes para adquirir 29,17 bezerros desmamados para engorda. Se considerarmos 5.000 bovinos vacinados forem considerados como população sob risco o coeficiente de morbidade seria de 0,36%. Os resultados deste estudo demonstram que perdas por reação vacinal, mesmo quando não provocam sinais cl

  1. Infecções causadas por fungos demácios e suas correlações anátomo-clinicas Infections caused by dematiaceous fungi and their anatomoclinical correlations

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    Camila de Camargo Hoffmann

    2011-02-01

    Full Text Available O gênero Exophiala é composto por fungos melanizados dimórficos, responsáveis por um espectro de doenças, incluindo feohifomicoses, micetomas, cromoblastomicoses e fungemia. A espécie E. jeanselmei é a predominante nestas infecções, seguida de E. dermatitidis. Este trabalho tem como objetivo relatar quatro casos e discutir aspectos clínicos, histológicos, micológicos e epidemiológicos para o seu diagnóstico.The Exophiala genus comprises dimorphic melanized fungi responsible for a spectrum of diseases including phaeohyphomycosis, mycetoma, chromoblastomycosis and fungemia. The E. jeanselmei species is predominant in such infections, followed by E. dermatitidis. This paper aims at reporting four cases and at discussing clinical, histologycal, mycologycal and epidemiologycal aspects for its diagnosis.

  2. Caracterización de la respuesta morfológica de variedades susceptibles y resistentes de yuca (Manihot esculenta Crantz a la bacteriosis vascular causada por Xanthomonas axonopodis pv. manihotis

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    Tamara Sandino

    2015-06-01

    Full Text Available Xanthomonas axonopodis pv. manihotis es una de las principales limitaciones del cultivo de yuca. En esta investigación, mediante microscopía óptica, se realizó un análisis comparativo de los cambios morfológicos e histoquímicos en tallos de una variedad de yuca susceptible (TMS60444 y una resistente (CM6438-14, 7 y 14 días después de ser inoculadas con la cepa patogénica CIO151. Se pudo detectar que la variedad resistente genera barreras de calosa en las paredes celulares del parénquima cortical y del floema, manteniendo funcional este tejido. En tanto que los tejidos vasculares de la variedad susceptible colapsan, el floema por obstrucción total con tapones de calosa y por formación de compuestos fenólicos, y el xilema por formación de tílides y/o acumulación de compuestos fenólicos, sin poder frenar el avance sistémico de la enfermedad.

  3. Lama glama con signología y lesiones compatibles con paratuberculosis causadas por Mycobacterium avium subespecie avium Lama glama with signology and lesion compatible with paratuberculosis and injuries caused by Mycobacterium avium subspecies avium

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    M.C Jorge

    2008-06-01

    Full Text Available Los camélidos sudamericanos (CS incluyen cuatro especies, guanaco, vicuña, alpaca y llama (Lama glama. En Argentina las llamas eran consideradas fauna y actualmente ganado, revalorizando su carne, fibra, cueros y pieles, también son un medio de subsistencia. Los CS son susceptibles a las enfermedades ocasionadas por micobacterias. El diagnóstico presuntivo se realiza por los signos clínicos y los hallazgos de necropsia y se confirma por técnicas bacteriológicas, moleculares e histopatología. El objetivo de este trabajo es describir un caso clínico con signos compatibles de paratuberculosis y el diagnóstico de laboratorio en una llama en cautiverio perteneciente a un zoológico de Olavarría, Provincia de Buenos Aires. En la necropsia se observaron lesiones granulomatosas en yeyuno, íleon y linfonodos mesentéricos compatibles con paratuberculosis, en los frotis directos y en la histopatología se observaron bacilos ácido-alcohol resistentes en cluster. Se confirmó la presencia de Mycobacterium avium subespecie avium por bacteriología y por PCR fue detectada la IS1245 característica de este agente, no detectando la IS900 correspondiente a Mycobacterium avium subespecie paratuberculosis. Esto permitió arribar al diagnóstico etiológico, combinando técnicas, de un caso de enteritis granulomatosa en llamas causado por Mycobacterium avium subespecie avium con signología y lesiones compatibles con paratuberculosis.Guanaco, vicuña, alpaca and llama (Lama glama are also known as Sudamerican camelids (SC. In Argentina llama was considered non profitable wildlife specie but now it is considered a mean for surviving because their meat, wool, leather and skin is valuable. SC are susceptible hosts of mycobacterial infections. A presumptive diagnosis is based on clinical and necropsy findings and is confirmed with bacterial isolation, molecular identification and histopathology. The objective of this publication is to describe a clinical

  4. Relación entre Condiciones de Suelo y Manejo de Huertas de Nogal Pecanero Carya illinoensis Koch con la Dinámica de la Pudrición Texana, causada por Phymatotrichum omnivorum Duggar

    OpenAIRE

    José Alfredo Samaniego Gaxiola; Teodoro Herrera Pérez; Aurelio Pedroza Sandoval; Jesús Santamaría César

    2001-01-01

    De 1995 a 1998, 26 lotes de tres ha cada uno fueron seleccionadas en huertas comerciales de nogal pecanero. El objetivo del muestreo fue relacionar la dinámica de la Pudrición Texana con el manejo de las huertas y condición de suelo. Las variables en el manejo del cultivo fueron: edad de los árboles, distancia de plantación, árboles por hectárea, manejo de plagas, número de riegos e incidencia de árboles enfermos (en 1995); para el factor suelo se consideraron tres profundidades (0-30, 30-60 ...

  5. Macrophages and Uveitis in Experimental Animal Models

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    Salvador Mérida

    2015-01-01

    Full Text Available Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In the last few years, experimental animal models of uveitis have enabled us to enhance our understanding of the leading role of macrophages in eye inflammation processes, including macrophage polarization in experimental autoimmune uveoretinitis and the major role of Toll-like receptor 4 in endotoxin-induced uveitis. This improved knowledge should guide advantageous iterative research to establish mechanisms and possible therapeutic targets for human uveitis resolution.

  6. Reações adversas causadas por fármacos que atuam no sistema nervoso: análise de registros de um centro de farmacovigilância do Brasil Adverse reaction caused by drugs acting in nervous system: records analysis of a farmacovigilance center in Brazil

    Directory of Open Access Journals (Sweden)

    Marta Maria de França Fonteles

    2009-01-01

    Full Text Available CONTEXTO: A morbimortalidade por uso de medicamentos é um grande problema de saúde. As reações adversas a medicamentos podem resultar em óbito, aumento de internações hospitalares e dos custos com a saúde. OBJETIVOS: Descrever e analisar as notificações de suspeitas de reações adversas causadas por medicamentos que atuam no sistema nervoso (RAM-SN, registradas no Centro de Farmacovigilância do Ceará, de janeiro de 1997 a março de 2008. MÉTODOS: As RAM-SN foram classificadas segundo os critérios da Organização Mundial da Saúde. Uma relação de causalidade entre o fármaco administrado e a reação adversa identificada foi realizada, bem como a análise da reação quanto à gravidade. RESULTADOS: Foram registradas 176 notificações de RAM-SN. A maioria (n = 145; 82,4% ocorreu no ambiente hospitalar. O principal notificador foi o farmacêutico. As RAM-SN foram classificadas como: possíveis (n = 110, prováveis (n = 37 e definidas (n = 17. Quanto à gravidade, foram consideradas: leves (n = 21, moderadas (n = 127, graves (n = 15 e fatais (n = 1. O caso fatal foi notificado por médico e envolveu medicamentos anestésicos. Geralmente, as reações adversas observadas foram causadas predominantemente por analgésicos, anestésicos e antiepilépticos. DISCUSSÃO: Os dados demonstram o valor potencial de se ter acesso a sistemas de farmacovigilância local para registrar possíveis riscos com o uso de fármacos.BACKGROUND: The morbi-mortality by the use of medicines is a major health problem. The drug adverse reactions may result in death, increased hospitalizations and healthcare costs. OBJECTIVES: Describe and analyze reports of suspected adverse reactions caused by drugs that act on the nervous system (SN-ADR, registered in the database of the Pharmacovigilance Centre of Ceará, from January 1997 to March 2008. METHODS: All the NS-ADRs were classified according to criteria of the World Health Organization. The causality

  7. The association between multiple sclerosis and uveitis

    DEFF Research Database (Denmark)

    Olsen, Tine Gadegaard; Frederiksen, Jette

    2016-01-01

    The association between multiple sclerosis (MS) and uveitis has been questioned. Nerve tissue and eye tissue develop from the same embryonic cells; thus, MS and uveitis could be etiologically associated. In published studies, the prevalence of MS in patients with uveitis differe from 0.7% to 30.......4%, whereas the prevalence of uveitis in patients with MS differe from 0.65% to 36.7%. Based on the largest retrospective studies, the prevalence of uveitis among MS patients is ∼1%, and the prevalence of MS among patients with uveitis is ∼1%. This is considerably higher than in the general population; thus......, more research on this topic is needed to further understand the relationship between MS and uveitis....

  8. Screening for uveitis in juvenile chronic arthritis.

    Science.gov (United States)

    Kanski, J J

    1989-03-01

    Three hundred and fifteen patients with anterior uveitis associated with juvenile chronic arthritis (JCA) were studied in order to identify the various risk factors for uveitis. Girls were more susceptible to uveitis than boys by a ratio of 3:1. In 94% of cases the uveitis was diagnosed after the development of arthritis. The risk of uveitis was small after seven or more years had elapsed from the onset of arthritis. Patients with pauciarticular onset JCA had the highest risk of uveitis and systemic onset patients the least risk. The presence of circulating antinuclear antibody was also an important marker for an increased risk of uveitis. A regimen for routine screening of patients is suggested.

  9. Chocolate das bagas e clorose foliar: anomalia da videira causada por deficiência de boro Internal browning ("chocolate" and leaf chlorosis of the 'pink Niagara' grafe, a boron deficiency anomaly

    Directory of Open Access Journals (Sweden)

    Hugo Kuniyuki

    1985-01-01

    Full Text Available A anomalia do cultivar de videira Niagara Rosada, caracterizada por sintomas de clorose nas folhas, chocolate das bagas e cachos malformados, não é de natureza virótica, de acordo com resultados de testes de transmissão e de perpetuação. Essa anomalia, presente em áreas definidas de alguns vinhedos de Indaiatuba e Jundiaí (SP, está associada à deficiência nutricional de boro. O teor médio de boro em amostras de plantas afetadas de 'Niagara Rosada' (18 ppm no limbo e 7 ppm nos frutos foi menor do que nas de plantas normais (24 ppm no limbo e 10 ppm nos frutos das mesmas plantaçoes; um material coletado de um vinhedo bastante afetado mostrou 13 e 1 ppm respectivamente no limbo e nos frutos de plantas deficientes contra 20 e 6 ppm nos de plantas sem sintomas. Amostras de três vinhedos vizinhos sem essa anomalia apresentaram um teor médio de 35 ppm no limbo. As do porta-enxerto 'Traviú' com clorose e sem clorose mostraram 16 ppm e 43 ppm de boro respectivamente. A aplicação de bórax, nas doses de 5, 10 e 20g por planta, 1ogo após a poda de inverno, ou pulverização de ácido bórico nas concentraçoes de 0,3% e 0,6% sobre a folhagem, durante o início do florescimento e durante a fase de uva chumbinho, permitiram controlar a anomalia nas condições de campo. Foi notada resposta favorável por um ciclo vegetativo, pelo menos, indicando controle por efeito residual de uma aplicação.The 'pink Niagara' grape (V. labrusca L. x V. vinifera L. anomaly characterized by leaf chlorosis and "chocolate" (internal browning of the young fruit, at first thought to be a virus disease, has been found to be a result of boron deficiency. The anomaly was first recorded in 1974. It occurs in patches in vineyards of Indaiatuba and Jundiaí, two grape-growing counties of the State of São Paulo, Brazil. Affected plants show yellowing between the primary and secondary veins of the upper leaves and malformed clusters, with normal-sized berries and

  10. Meningoencefalite em bovinos causada por herpesvírus bovino-5 no Mato Grosso do Sul e São Paulo Meningoencephalitis in cattle caused by bovine herpesvirus-5 in Mato Grosso do Sul and São Paulo

    Directory of Open Access Journals (Sweden)

    Sandro César Salvador

    1998-04-01

    Full Text Available Quinze focos de meningoencefalite por herpesvírus bovino-5 (BHV-5 foram diagnosticados entre agosto de 1993 e dezembro de 1996, sendo 14 provenientes do estado do Mato Grosso do Sul e um do estado de São Paulo. A doença ocorreu em diversos municípios e em diferentes épocas do ano. Foram afetados bovinos de 6 a 60 meses de idade, com uma morbidade de 0,05% a 5% e letalidade próxima a 100%. Os sinais clínicos foram exclusivamente nervosos e o curso da enfermidade variou de 1 a 15 dias. As principais lesões histológicas detectadas foram meningite e encefalite difusa com malacia do córtex cerebral e presença de corpúsculos de inclusão intranucleares em astrócitos e neurônios. O vírus foi isolado do cérebro de 11 de um total de 12 animais, e sua identidade confirmada por imunoperoxidase, utilizando-se anticorpos monoclonais específicos. Os surtos de encefalite por BHV-5 representam 5% dos diagnósticos realizados em bovinos pelo Hospital Veterinário da Universidade Federal do Mato Grosso do Sul. Os resultados deste trabalho evidenciam a importância da doença no Mato Grosso do Sul e indicam a necessidade de incluir a encefalite por BHV-5 no diagnóstico diferencial de outras doenças do sistema nervoso de bovinos frequentes no Estado.Fifteen outbreaks of bovine herpesvirus-type 5 (BHV-5 infection were diagnosed from August 1993 to December 1996. Fourteen outbreaks occurred in the State of Mato Grosso do Sul and one in the State of São Paulo. Cattle 6 to 60 months old were affected. Morbidity reached 0.05% to 5% and case fatality rate was nearly 100%. The disease occurred in different municipalities and at different times of the year. Clinical signs were exclusively nervous, and the clinical course varied from 1 to 15 days. The main histologic lesions were meningitis, diffuse encephalitis and necrosis of the cerebral cortex with intranuclear inclusion bodies in astrocytes and neurons. BHV-5 was isolated from 11 out of 12 brains of

  11. Estimativas de perdas econômicas causadas por reação granulomatosa local após uso de vacina oleosa contra febre aftosa em bovinos de Mato Grosso do Sul

    OpenAIRE

    Paula V. Leal; Pupin,Rayane C.; Ariany C. Santos; Tatiane C. Faccin; Eduardo Surdi; Leal,Cassia R.B.; Ricardo Carneiro Brumatti; Lemos,Ricardo A.A.

    2014-01-01

    Lesões exacerbadas à vacina contra a febre aftosa foram observadas em 1.815 de um total de 5.000 bovinos abatidos em frigorífico com inspeção federal. Essas lesões resultaram na condenação de parte das carcaças de acordo com o Regulamento da Inspeção Industrial e Sanitária de Produtos de Origem Animal. Os bovinos haviam sido vacinados em maio de 2012 e abatidos em setembro do mesmo ano e divididos em Lotes 1 e 2 constituídos respectivamente por 1.500 e 315 bovinos. As lesões de reação vacinal...

  12. Prevalência da mordida aberta anterior causada por hábitos deletérios de sucção em crianças de cinco anos de idade

    OpenAIRE

    Rosseto, Célia Maria Mamoni

    2015-01-01

    As maloclusões são problemas de saúde bucal em Saúde Coletiva, definidas como agravos à saúde pela Organização Mundial de Saúde. Representam variações significantes do crescimento e da morfologia dos arcos dentários comprometendo funções e a estética do indivíduo. Uma das maloclusões é a mordida aberta, caracterizada por uma deficiência no contato vertical normal entre os dentes antagonistas, que pode manifestar-se em uma região limitada ou, mais raramente, em todo o arco dentário. Quando a f...

  13. Primary cutaneous cryptococcosis due to Cryptococcus neoformans var. gattii serotype B, in an immunocompetent patient Criptococose cutânea primária causada por Cryptococcus neoformans var. gattii sorotipo B em paciente imunocomprometido

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    Carlos da Silva LACAZ

    2002-07-01

    Full Text Available The authors report a male patient, a seller with no detected immunosuppression, with an extensive ulcerated skin lesion localized on the left forearm, caused by Cryptococcus neoformans var. gattii serotype B. Oral treatment with fluconazole was successful. A review of the literature showed the rarity of this localization in HIV-negative patients. In contrast, skin lesions frequently occurs in HIV-positive patients, with Cryptococcus neoformans var. neoformans serotype A predominating as the etiological agent. In this paper, the pathogenicity of C. neoformans to skin lesions in patients immunocompromised or not, is discussed, showing the efficacy of fluconazole for the treatment of these processes.Os autores registram em paciente do sexo masculino, vendedor ambulante sem qualquer doença de base, lesão cutânea extensa, localizada no antebraço esquerdo, sob forma ulcerada, provocada pelo Cryptococcus neoformans var. gattii sorotipo B. Sucesso terapêutico com fluconazol, por via oral. Revisão da literatura foi realizada, mostrando raridade de tal localização em pacientes HIV-negativos. Já em pacientes HIV-positivos, lesões cutâneas ocorrem com freqüência, predominando como agente etiológico o Cryptococcus neoformans var. neoformans, sorotipo A. A patogenicidade do C. neoformans nas lesões cutâneas é discutida em pacientes imunocomprometidos ou não, mostrando a eficácia do fluconazol no tratamento de tais processos.

  14. Epidemiology of extended spectrum β-lactamase producing Enterobacter bacteremia in a brazilian hospital Epidemiologia de bacteremia causadas por Enterobacter produtores de β-lactamases de espectro estendido em um hospital brasileiro

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    Felipe Francisco Tuon

    2010-08-01

    Full Text Available INTRODUCTION: Enterobacter can be included in the group of extended spectrum β-lactamases (EBSL-producing bacteria, though few studies exist evaluating risk factors associated with this microorganism. A retrospective cohort study was conducted to determine risk factors associated with ESBL-producing-Enterobacter and mortality METHODS: A retrospective cohort study with 58 bacteremia caused by ESBL-producing-Enterobacter (28 cases and non-ESBL (30 cases RESULTS: Risk factors associated with ESBL-Enterobacter were trauma, length of hospitalization, admission to the intensive care unit, urinary catheter and elective surgery (pINTRODUÇÃO: Enterobacter pode ser incluído no grupo de bactérias produtoras de β-lactamases de espectro estendido (ESBL, mas existem poucos estudos avaliando fatores de risco para ESBL. Nós realizamos uma coorte retrospective para determiner fatores de risco associados com Enterobacter produtores de ESBL MÉTODOS: Uma coorte retrospectiva com 58 bacteremias por Enterobacter ESBL (28 casos e não-ESBL (30 casos RESULTADOS: Fatores de risco para ESBL-Enterobacter foram trauma, tempo de internação, admissão em UTI, sonda vesical e cirurgia eletiva (p<0.05. A mortalidade foi similar entre ESBL e não-ESBL CONCLUSÕES: Enterobacter produtor de ESBL é prevalente e a curva de mortalidade foi semelhante com o grupo não-ESBL.

  15. Insuficiência respiratória aguda causada por pneumonia em organização secundária à terapia antineoplásica para linfoma não Hodgkin

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    Adriell Ramalho Santana

    2012-12-01

    Full Text Available Doenças difusas do parênquima pulmonar pertencem a um grupo de doenças de evolução geralmente subaguda ou crônica, mas que podem determinar insuficiência respiratória aguda. Paciente masculino, 37 anos, em terapia para linfoma não Hodgkin, admitido com tosse seca, febre, dispneia e insuficiência respiratória aguda hipoxêmica. Iniciadas ventilação mecânica e antibioticoterapia, porém houve evolução desfavorável. Tomografia computadorizada de tórax mostrava opacidades pulmonares em "vidro fosco" bilaterais. Devido ao paciente ter feito uso de três drogas relacionadas à pneumonia em organização (ciclofosfamida, doxorrubicina e rituximabe e quadros clínico e radiológico serem sugestivos, iniciou-se pulsoterapia com metilprednisolona com boa resposta. Pneumonia em organização pode ser idiopática ou associada a colagenoses, drogas e neoplasias, e geralmente responde bem a corticoterapia. O diagnóstico é anatomopatológico, mas condições clínicas do paciente não permitiam a realização de biópsia pulmonar. Pneumonia em organização deve ser diagnóstico diferencial em pacientes com aparente pneumonia de evolução desfavorável ao tratamento antimicrobiano.

  16. Cutaneous cryptococcosis due to Cryptococcus gattii in a patient on chronic corticotherapy Criptococose cutânea causada por Cryptococcus gattii em um paciente sob corticoterapia crônica

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    Fernando Bellissimo-Rodrigues

    2010-04-01

    Full Text Available Cryptococcus gattii causes a form of endemic mycosis that most commonly affects the lungs and central nervous system of immunocompetent patients living in tropical and subtropical areas of the world. Case report. A 66-year-old man who had chronic obstructive pulmonary disease without HIV infection and had been on systemic corticotherapy for several years developed extensive ulceration of the left forearm that was associated with ipsilateral supraclavicular adenomegaly, consequent to infection with Cryptococcus gattii. The patient was treated with fluconazole 400mg/day for eight months, which led to complete healing of the lesion. This case emphasizes that, although rare, C. gattii may cause opportunistic cutaneous-lymphatic infection in patients living in the southeastern region of Brazil who are immunocompromised through chronic corticotherapy.Cryptococcus gattii é agente causador de uma micose endêmica que afeta principalmente os pulmões e o sistema nervoso central de pacientes imunocompetentes em regiões tropicais e subtropicais do globo. Relato de caso. Um paciente de 66 anos, portador de doença pulmonar obstrutiva crônica, não infectado pelo vírus HIV, em corticoterapia sistêmica prolongada, desenvolveu extensa ulceração do antebraço esquerdo, associada a adenomegalia supraclavicular ipsilateral, em conseqüência à infecção por Cryptococcus gattii. O paciente foi tratado com fluconazol 400mg/dia durante 8 meses, obtendo resolução completa da lesão. Este caso enfatiza que, ainda que raramente, C. gattii pode causar infecção cutâneo-linfática oportunista, em paciente imunocomprometido pelo uso sistêmico de corticosteróides vivendo na região sudeste do Brasil.

  17. Impact of the Haemophilus influenzae type b vaccination program on HIB meningitis in Brazil Impacto do programa de vacinação contra meningites causadas por Haemophilus influenzae tipo b no Brasil

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    Sybelle de Souza Castro Miranzi

    2007-07-01

    Full Text Available This study aimed to evaluate the impact of vaccination against Haemophilus influenzae type b (HIB in Brazil on the morbidity, mortality, and case fatality of HIB meningitis, using the Ministry of Health database and population data from the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística - IBGE. Impact was evaluated through a time series analysis (1983-2002, using regression forecasting (RF by dividing the time series into two periods: (a historical (1983-1998 and (b validation (1999-2002. Impact of the vaccination was positive, although more significant for incidence and mortality than for case fatality rates.A proposta deste trabalho foi avaliar o impacto da vacinação contra Haemophilus influenzae tipo b (HIB no Brasil sobre a morbi-mortalidade e a letalidade das meningites por HIB, a partir de base de dados fornecida pelo Ministério da Saúde e as estimativas populacionais provenientes do Instituto Brasileiro de Geografia e Estatística (IBGE. Para a avaliação do impacto utilizou-se análise de tendência temporal (1983-2002, aplicando-se a técnica RF (regression forecasting, dividindo-se a série em dois períodos: (a período histórico (1983-1998 e (b período de estimação (1999-2002. O impacto da vacinação foi positivo, embora tenha se revelado mais expressivo sobre a morbi-mortalidade que sobre a letalidade.

  18. Endocardite valvar mitral causada por Chlamydia psittaci: apresentação de um caso raro Chlamydia psittaci as a cause of mitral valve endocarditis: presentation of a rare case

    Directory of Open Access Journals (Sweden)

    Rinaldo Luiz Wolker

    2006-06-01

    Full Text Available Relatamos o caso de um criador de pássaros que desenvolveu um quadro consuntivo, febril, com mialgia e hemoculturas negativas. Internado por três ocasiões, foi tratado empiricamente com antibióticos, sem melhora. Após quatro meses, apresentou piora com sinais de infecção sistêmica. Ecocardiograma demonstrou insuficiência mitral moderada, com vegetações, não presentes em exame prévio. Sorologia positiva para Chlamydia psittaci (imunofluorescência indireta. Na cirurgia, identificou-se grande destruição da valva mitral, com cúspide anterior rota e vegetações. Após a cirurgia, apresentou melhora clínica, recebendo alta em treze dias, com antibioticoterapia específica. Apesar de pouco freqüente, a Chlamydia psittaci deve ser lembrada em casos de endocardite com hemoculturas negativas, quando houver história de exposição a pássaros.The authors report a clinical case of bird breeder who evolved with fever, myalgia, weight lost and negative blood cultures. On three occasions he was treated with different antibiotics, without improvement. He became progressively worse and after four months a diagnosis of endocarditis was made. An echocardiogram showed mitral valve dysfunction with vegetation that had not been seen previously. A blood test proved positive for Chlamydia psittaci (indirect immunofluorescence. In surgery the mitral valve was seen to have severe lesions with anterior cuspid rupture and large areas with vegetation. After surgery, he presented with a clinical improvement and was discharged on the thirteenth post-operative day on specific antibiotic therapy. Although rare, Chlamydia psittaci must be considered in cases of endocarditis with negative blood cultures, when there is a possibility of contact with birds.

  19. Coleção fluídica na interface do LASIK causada por glaucoma secundário à ceratouveíte herpética: relato de caso LASIK interface fluid accumulation caused by glaucoma associated with herpetic keratouveitis: case report

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    Eliane Mayumi Nakano

    2007-02-01

    Full Text Available A infecção por Herpes simplex vírus (HSV é causa freqüente de inflamação intra-ocular ou uveíte anterior. A hipertensão ocular é característica comumente observada nas ceratouveítes herpéticas. Neste relato descrevemos o acúmulo de fluido e descolamento do "flap" corneano da ceratomileusis, no pós-operatório tardio de LASIK (28 meses, associado a quadro hipertensivo ocular secundário a ceratouveíte herpética. Este achado corrobora a suposição que a cicatrização corneana após LASIK seja apenas parcial e o espaço virtual produzido pela ceratomileuisis permaneça indefinidamente. Condições de aumento excessivo da pressão intra-ocular podem causar edema corneano com acúmulo de fluido da interface.Herpes simplex virus infection is a frequent cause of intraocular inflammation or anterior uveitis. Ocular hypertension is a common feature in herpetic keratouveitis. We describe a fluid accumulation and flap displacement in late postoperative period (28 months of LASIK associated with ocular hypertension caused by herpetic keratouveitis. This finding supports the theory that flap attachment after LASIK is only partial and the virtual space remains indefinitely. The presence of ocular hypertension may lead to corneal edema and fluid accumulation in the interface.

  20. Uveitis--manifestation af syfilis

    DEFF Research Database (Denmark)

    Andersen, Ellen Sloth; Kofoed, Kristian; Andersen, Mads Varis Nis

    2007-01-01

    We describe two cases of neurosyphilis whose diagnosis was based on ocular symptoms. Both patients were treated in the Eye Department for bilateral uveitis, and they were tested serologically positive for syphilis. The diagnoses of neurosyphilis were confirmed by demonstration of CSF pleocytosis ...

  1. La marchitez tardía del maíz (Zea mays L. causada por Cephalosporium maydis en la Península Ibérica, y otros hongos asociados

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    Carmen Maria Ortiz-Bustos

    2015-06-01

    Full Text Available Las especies de hongos de suelo asociadas a Cephalosporium maydis como agente causal de la marchitez tardía del maíz en la Península Ibérica se identificaron muestreando 19 campos con síntomas de marchitez en las principales zonas de cultivo entre 2011 y 2012. En el 47% de los campos no se identificó C. maydis, pero sí Fusarium graminearum, F. verticillioides, F. equiseti, F. proliferatum, Macrophomina phaseolina, Rhizoctonia solani y Trichoderma harzianum infectando las plantas de maíz. En los campos restantes, junto a C. maydis se identificaron otros hongos de suelo en porcentajes apreciables: F. verticillioides (19%, F. proliferatum (19%, F.equiseti (9%, F. oxysporum (9% y Pythium oligandrum (9%. El crecimiento vascular de C. maydis y de otras especies fúngicas en plantas de maíz se confirmó analizando plantas con marchitez procedentes de tres campos diferentes. Tanto C. maydis como F. graminearum, F. equiseti, F. proliferatum y T. harzianum se aislaron de la inserción entre la raíz y tallo y a 10 cm de altura en el tallo de las plantas. El efecto de la infección por C. maydis sobre la producción de las plantas de maíz se cuantificó en macetas y condiciones seminaturales en el 2011. En plantas inoculadas se obtuvo una reducción del peso de las mazorcas del 54%, además de pesos de raíz y de parte aérea (tallo y hojas significativamente menores en comparación con el control no inoculado, lo que sugiere el gran impacto económico que puede tener la marchitez tardía en condiciones naturales. Asimismo este trabajo pone de manifiesto el grado de complejidad de la etiología de la marchitez tardía, que debería ser estudiado mediante la confirmación de la patogenicidad de los hongos de suelo identificados en maíz, con el fin de determinar el papel que puede jugar cada una de estas especies en el desarrollo de la enfermedad y/o severidad de los síntomas.

  2. Relación entre Incidencia y Severidad de la Roya Asiática de la Soya Causada por Phakopsora pachyrhizi Sydow & Sydow Relationship Between Incidence and Severity of Asian Soybean Rust Caused by Phakopsora pachyrhizi Sydow & Sydow

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    Felipe Rafael Garcés Fiallos

    2011-12-01

    Full Text Available Se relaciona la incidencia con la severidad de la roya asiática de la soya, donde los valores generados por las ecuaciones pueden ser usados en cualquier estudio de este patosistema, proporcionando una herramienta para evaluar la incidencia como también la severidad. Se generaron gradientes de la enfermedad mediante el uso de fungicidas y momentos de aplicación, de manera preventiva y curativa. El experimento de campo con el cultivar Nidera 5909 RG, fue distribuido en bloques completos al azar. La intensidad de la roya asiática fue medida en los estratos inferior, medio y superior de la planta, a través de diferentes conteos de incidencia (porcentaje y severidad (lesiones cm-2, urédias cm-2 y porcentaje en folíolos. Las regresiones realizadas, presentaron una correlación significativa entre incidencia y severidad a 1% de probabilidad. Con los datos obtenidos, el evaluador puede escoger el método de cuantificación mas razonable o confiable a su criterio para otros trabajos de investigación o aplicar un determinado control de la enfermedad, utilizando las ecuaciones lineales generadas, facilitando el trabajo de cuantificar la roya asiática, bien se busque medir la incidencia (% o el número de lesiones cm-2, urédias cm-2 o severidad (%.Incidence is related to severity of the Asian soybean rust, where values generated by the equations can be used in any study of this pathosystem, providing a tool to evaluate incidence as well severity. Gradients of the disease were generated by means of the use of fungicides and moments of application, in a preventive and curative way. The field experiment with the cultivar Nidera RG 5909, was distributed in a randomized complete block. The intensity of Asian rust layers was measured in the lower, middle and top of the plant, through various counts of incidence (percentage and severity (lesions cm-2, uredinia cm-2 and percentage in leaflets. The regressions showed a significant correlation between

  3. Fatores de risco e letalidade de infecção da corrente sanguínea laboratorialmente confirmada, causada por patógenos não contaminantes da pele em recém-nascidos

    Directory of Open Access Journals (Sweden)

    Roberta M.C. Romanelli

    2013-04-01

    Full Text Available OBJETIVO: Avaliar os fatores de risco e a letalidade da infecção da corrente sanguínea laboratorialmente confirmada (ICSLC de início tardio em uma Unidade Neonatal de Cuidados Progressivos (UNCP brasileira. MÉTODOS: Trata-se de um estudo caso-controle realizado de 2008 a 2012. Os casos foram definidos como todos os recém-nascidos com ICSLC de início tardio, excluindo pacientes isolados com contaminantes da pele comuns. Os controles foram recém-nascidos que não mostraram qualquer evidência de ICSLC de início tardio, sendo separados por peso e tempo de permanência na UNCP. As variáveis foram obtidas na base de dados da Comissão de Controle de Infecção Hospitalar (CCIH. A análise foi realizada utilizando o Pacote Estatístico para Ciências Sociais. O teste χ² foi utilizado e a relevância estatística foi definida como p < 0,05, seguida pela análise multivariada. RESULTADOS: No estudo, 50 pacientes com ICSLC de início tardio foram combinados com 100 pacientes sem ICSLC de início tardio. No grupo de pacientes com ICSLC de início tardio, identificamos uma proporção significativamente maior de pacientes que foram submetidos a procedimentos cirúrgicos (p = 0,001 e que usaram cateter venoso central (CVC (p = 0,012 e ventilação mecânica (p = 0,001. Na análise multivariada, cirurgia prévia e uso de CVC permaneceram significativamente associados à infecção (p = 0,006 e p = 0,047; OU: 4,47 e 8,99, respectivamente. A Enterobacteriacea foi identificada em 14 casos, com três (21,4% óbitos, e Staphylococcus aureus foi identificado em 20 casos, com três (15% óbitos. CONCLUSÕES: Procedimentos cirúrgicos e uso de CVC constituíram fatores de risco significativos para ICSLC. Portanto, práticas de prevenção para cirurgia segura, inserção e manipulação de CVC são essenciais para reduzir essas infecções, além de treinamento e educação contínua às equipes cirúrgicas e de assistência.

  4. [Epidemiologic profile of uveitis: about 105 cases].

    Science.gov (United States)

    Souley, Abdoul Salam Youssoufou; Abdellah, Hamed Ould Mohamed; Khmamouche, Mehdi; Naji, Alwan Alsubari; Elasri, El Ouatassi Narjis Fouad; Reda, Karim; Oubaaz, Abdelbarre

    2016-01-01

    The multiplicity of causes of uveitis makes diagnosis difficult. Determining epidemiological factors associated with uveitis allows better diagnostic orientation and facilitates therapeutic management. This is a retrospective study spanning four years from January 2012 to December 2015. We collected 105 cases with uveitis and studied its epidemiological, clinical and etiological aspects. The average age was 42 years, the most affected age group was 40-50 years. Men were more affected (57.14%) than women (42.86%). Uveitis was unilateral in 60.95% of cases. Anterior uveitis was found in 35.24%, intermediate uveitis in 5.71%, posterior uveitis in 10.48% and panuveitis in 48.57%. Etiologies were dominated by Behçet's disease, sarcoidosis and Vogt-Koyanagi-Harada disease. The origin remained unknown in 43.81% of cases. The evolution was variable. Uveitis is an intraocular inflammation which may represent a real threat to vision. The approach to discover its cause needs to be codified and based on several steps. Our results are relatively close to those found in the literature. Uveitis is a clinical entity where ophthalmology and internal medicine meet. The field of its causes and investigations for the diagnosis is extensive or even unlimited. This study highlighted the clinical challenges and emphasized the limitations of our clinical training in the management of uveitis.

  5. Efeitos da esplenectomia na peritonite causada por lesão traumática do cólon: estudo em ratos Effects of splenectomy on peritonitis produced by a colonic injury: study in rats

    Directory of Open Access Journals (Sweden)

    Luís Sérgio Nassif

    2004-09-01

    Full Text Available OBJETIVO: Estudar o efeito da esplenectomia na infecção intra-abdominal com bactérias da flora enteral, liberadas para a cavidade abdominal através de uma lesão induzida no cólon de ratos Wistar. MÉTODOS: Foram utilizados 64 animais, sendo 20 do Grupo A1 (normais sem sutura da lesão, 22 do Grupo A2 (normais com sutura da lesão e 22 do Grupo B (esplenectomizados e com sutura da lesão. Os animais foram submetidos à laparotomia mediana e a indução da peritonite intra-operatória foi obtida através de lesão do cólon previamente distendido pela introdução de uma sonda naso-gástrica via retal e injeção de 2 ml de soro fisiológico. Foram realizados exames bacteriológicos de lavado abdominal obtido por swab esterelizado e exame microscópico de segmento suturado do cólon de amostras obtidas dos grupos A2 e B com 48hs, 96hs e 12 dias de pós-operatório. Todos os animais foram submetidos a necropsia por ocasião do óbito ou no 12º. dia de pós-operatório quando os sobreviventes foram sacrificados. RESULTADOS: Agentes bacterianos semelhantes foram encontrados nos três grupos: E.coli (100%; Enterococcus faecalis (97%; P. mirabilis (90%; Klebsiela pneumoniae (70%; Citobacter freundi (70% e Enterobacter aglomerans (63%. O exame microscópico revelou menor reação inflamatória no grupo esplenectomizado. A causa da morte na maioria foi peritonite nas primeiras 96hs. Houve alto índice de significância de mortalidade entre os animais do Grupo B (80% em relação ao Grupo A2 (sem mortalidade e em relação ao Grupo A1 (35%. CONCLUSÃO: Houve alto índice de significância de mortalidade em vigência de peritonite nos animais esplenectomizados em relação aos animais que não foram esplenectomizados.BACKGROUND: Study the effects of splenectomy on the intra-abdominal infection by bowel flora, consequent to a colonic injury in Wistar rats. METHODS: We used 64 animals, 20 for Group A1 (normal with colon lesion left open, 22 for Group

  6. Therapeutic trial in experimental tegumentary leishmaniasis caused by Leishmania (Leishmania amazonensis. A comparative study between mefloquine and aminosidine Ensaio terapêutico na leishmaniose tegumentar experimental causada por Leishmania (Leishmania amazonensis. Um estudo comparativo entre mefloquina e aminosidine

    Directory of Open Access Journals (Sweden)

    Letícia Oba Galvão

    2000-08-01

    mefloquina (16mg/kg/dia/10 dias, 2 52 animais tratados com aminosidina [Paramomicina ®] (20mg/kg/dia/20 dias, 3 78 animais controles, não manipulados. Vinte e seis animais de cada grupo tratado foram sacrificados nove e quinze semanas após a inoculação. Animais do grupo controle foram sacrificados na sexta, nona e décima quinta semanas após a inoculação. Ao final do tratamento, em relação à curva de peso da orelhas, somente nos animais tratados com aminosidina, houve nítida redução do peso em comparação com grupo controle. Na histopatologia verificou-se: a não houve diferença entre o grupo tratado com mefloquina e o grupo controle; o grupo tratado com aminosidina, ao final do tratamento, teve menor infiltração por macrófagos vacuolizados; b as avaliações da extensão das áreas de necrose e do nível da fibrose tecidual não mostraram diferenças entre os grupos tratados. Os animais do grupo controle apresentaram fibrose mais acentuada, seis semanas após o fim do tratamento. Pode-se concluir que ocorreu efeito terapêutico reduzido com a mefloquina e houve significativa melhora com a aminosidina. Entretanto, em todos os grupos as lesões não chegaram a curar.

  7. Padrão dermatoscópico das alopecias cicatriciais causadas por lúpus eritematoso discoide e líquen plano pilar Dermoscopy patterns of cicatricial alopecia resulting from discoid lupus erythematosus and lichen planopilaris

    Directory of Open Access Journals (Sweden)

    Bruna Duque Estrada

    2010-04-01

    Full Text Available FUNDAMENTOS: A dermatoscopia é método importante de diagnóstico de doenças melanocíticas benignas e malignas. Recentemente, o uso desse método tem demonstrado grande ajuda também no diagnóstico e acompanhamento das alopecias. OBJETIVO: Descrever e demonstrar os achados dermatoscópicos de pacientes com quadros clínicos e histopatológicos de alopecia cicatricial. MÉTODOS: Estudo transversal descritivo em que foram selecionados, pelos achados clínicos e histopatológicos do couro cabeludo, 14 pacientes com alopecia cicatricial, sendo quatro casos de líquen plano pilar clássico, cinco casos de alopecia fibrosante frontal e cinco com lúpus eritematoso discoide. Os pacientes foram avaliados com videodermatoscópio e dermatoscópio manual por três examinadores diferentes, de forma independente. Os aumentos variaram de 10 a 70 vezes. RESULTADOS: Foram achados predominantes no lúpus eritematoso discoide placas brancas, capilares arboriformes, tampões ceratósicos e áreas com diminuição dos óstios foliculares; no líquen plano pilar clássico, escamas perifoliculares, pontos brancos e diminuição de óstios foliculares; na alopecia fibrosante frontal, diminuição de óstios foliculares, escama e eritema perifolicular, além de capilares arboriformes. As estruturas azul-acinzentadas, demonstradas neste estudo, não foram descritas na literatura. CONCLUSÕES: O uso da dermatoscopia na avaliação clínica das alopecias ajudou a estabelecer elementos semióticos, melhorou a capacidade de diagnóstico em relação à simples inspeção e revelou novas características das alopecias cicatriciais.BACKGROUND: Dermoscopy is an important tool for the diagnosis of benign and malignant melanocytic diseases. Recently, this method has also been found to be extremely useful in the diagnosis and follow-up of alopecias. OBJECTIVE: The objective of this study was to describe dermoscopic findings in patients with clinical and histopathological

  8. Estudos histomorfométrico e histológico das lesões ósseas causadas por flúor em aves Histomorphometric and histological evaluations of the bone lesions caused by fluoride in chickens

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    Margarida Buss Raffi

    1997-04-01

    Full Text Available Fluoreto de sódio foi administrado na água de 2 grupos de 25 aves, fêmeas, da raça Shaver. O grupo A recebeu flúor do 1 ao 120 dia de idade e o grupo B do 61 ao 120 dia de idade. Cada grupo foi dividido em 5 níveis de tratamento: 0, 25, 50, 200 e 400 ppm de flúor, com 5 animais por tratamento. Todos os animais foram sacrificados aos 120 dias de idade. Para o estudo histomorfométrico foram coletados o fêmur e a tíbia esquerdos, e para o estudo histológico foram coletados fêmur e tíbia direitos. No estudo histomorfométrico do osso compacto observou-se um discreto aumento da porosidade cortical, que não foi estatisticamente significativo. A espessura do osso cortical aumentou nos animais tratados com flúor (pSodium fluoride was administered in the water to 2 groups of 25 Shaver female poultry. Group A received fluoride from 1 to 120 days of age and group B from 61 to 120 days. Each group was divided into 5 treatments, with 5 chickens each, which received 0, 25, 50, 200, and 400 ppm of fluoride in the water, respectively. All animals were killed at 120 days of age. For histomorphometric studies the left femur and tibia were used, and for histologic studies the right femur and tibia. In the cortical bone, cortical porosity was slightly increased by fluoride, but the differences with the control group were not significant. Cortical thickness increased in the animals treated with fluoride (p<0,05, r2 = 0,59 . In the trabecular bone, of group A, trabecular thickness (TT (p<0,05, r2 = 0,63 and trabecular bone volume (TBV (p<0,05, r2 = 0,72 increased in treatments receiving 25-200 ppm, and decreased in the 400 ppm treatment, as it was demonstrated by quadratic regression analysis. In group B there was a positive linear correlation on TT (p<0,05, r2 = 0,98 and TBV (p<0,05, r2 = 0,77 with fluoride ingestion.The osteoid surface was also positively correlated with the amount of fluoride ingested by the animals (p<0,001, r2 = 0,80. These

  9. Linfadenite granulomatosa em suínos: linfonodos afetados e diagnóstico patológico da infecção causada por agentes do Complexo Mycobacterium avium Granulomatous lymphadenitis in swine: lymph nodes affected and pathologic diagnosis of the infection caused by Mycobacterium avium Complex agents

    Directory of Open Access Journals (Sweden)

    Nelson Morés

    2007-01-01

    Full Text Available Realizou-se um estudo com o objetivo de avaliar a distribuição de lesões granulomatosas nos linfonodos das carcaças de suínos abatidos e de comparar os métodos de isolamento do Complexo Mycobacterium avium (MAC, coloração de Ziehl-Neelsen (ZN, exames histopatológico e de imunohisto-química (IHQ para o diagnóstico da linfadenite granulomatosa causada por micobactérias do MAC. Foram utilizadas 431 amostras de linfonodos colhidos de 394 carcaças de suínos abatidos em 12 frigoríficos da Região Sul do Brasil, com o Serviço de Inspeção Federal (SIF. Os linfonodos que apresentavam lesões granulomatosas foram submetidos aos exames histológicos, ZN e IHQ com anticorpo monoclonal produzido com extrato celular de M. avium. A concordância entre os exames foi medida pelo teste Kappa, com nível de confiança de 95%. O exame macroscópico realizado pelo SIF identifica corretamente 90,3% das lesões granulomatosas, quando comparado com o exame histológico e a maioria das carcaças (92,5 apresentam lesões apenas nos linfonodos cadeia alimentar. O exame histológico confirmou a presença de lesões granulo-matosas em 90,3% dos linfonodos. As concordâncias entre os exames histopatológico e coloração de ZN (Kappa: 0,342 e de IHQ e o isolamento do MAC (Kappa: 0,102 foram baixas, porém alta entre os exames de IHQ e histológico com a presença de granulomas típicos nos linfonodos (Kappa: 0,973. O exame de IHQ associado ao exame histopatológico mostrou-se eficiente na identificação das lesões de linfadenite granulomatosa causadas pelo MAC.A study to evaluate the distribution of granulomatous lesions in the lymph nodes of swine carcasses was accomplished. The main objective was to compare the methods of isolation of mycobacteria of the Mycobacterium avium Complex (MAC, Ziehl-Neelsen (ZN staining, histopathological examination and immunohistochemistry (IHC for the diagnosis of granulomatous lymphadenitis caused by MAC. A total of 431

  10. Alterations of the myenteric plexus of the ileum and the descending colon caused by Toxoplasma gondii (genotype III Alterações do plexo mientérico do íleo e cólon descendente causadas por Toxoplasma gondii (genótipo III

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    Elaine Yae Yamashita Sugauara

    2008-09-01

    Full Text Available Alterations caused by a genotype III strain of Toxoplasma gondii were assessed with respect to the number and the morphometry of the myenteric neurons in the terminal ileum and the descending colon. Eighteen rats were divided into four groups: Acute Control Group (ACG, n=4; Acute Experimental Group (AEG, n=4; Chronic Control Group (CCG, n=5 and Chronic Experimental Group (CEG, n=5. NaCl solution was administered through gavage to the animals in the ACG and CCG. Toxoplasma gondii tachyzoites (10(4 from a genotype III strain were orally administered to the AEG and CEG. Acute Groups were died after 24 hours, and the Chronic Groups after 30 days. Neuronal loss was not observed in both organs. The neurons atrophied in the terminal ileum as the opposite occurred with the neurons at the descending colon during the chronic phase of infection. In the terminal ileum, the neurons atrophied during the chronic phase of the infection as no alteration was found during the acute phase. For the descending colon, the neurons became hypertrophic during the chronic infection in opposition to the atrophy found during the acute phase.Objetivou-se avaliar as alterações causadas por uma cepa genótipo III de Toxoplasma gondii, sobre o número e a morfometria de neurônios mientéricos, do íleo terminal e do cólon descendente. Dividiu-se dezoitos ratos em quatro grupos: controle agudo (GCA, n=4, experimental agudo (GEA, n=4, controle crônico (GCC, n=5 e experimental crônico (GEC, n=5. Os animais do GCA e GCC receberam solução de NaCl por gavagem, e os animais do GEA e GEC 10(4 taquizoítos de uma cepa genótipo III de T. gondii por via oral. Os grupos agudos após 24 horas foram mortos e os crônicos após 30 dias. Observou-se que não houve perda neuronal em ambos os órgãos. No íleo terminal, os neurônios atrofiaram-se na fase crônica da infecção, enquanto nenhuma alteração ocorreu na fase aguda. Já no cólon descendente, os neurônios tornaram

  11. Intermediate uveitis, posterior uveitis, and panuveitis in the Mid-Atlantic USA

    OpenAIRE

    Engelhard SB; Patel V; Reddy AK

    2015-01-01

    Stephanie B Engelhard, Vandan Patel, Ashvini K Reddy Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA Background: The purpose of this study was to identify the causes, clinical features, and outcomes of intermediate uveitis, posterior uveitis, and panuveitis in patients managed in a mid-Atlantic tertiary care center.Methods: This was a retrospective observational study of intermediate uveitis, posterior uveitis, and panuveitis patients seen at the University of...

  12. Resultados de una encuesta sobre tratamiento de la cifosis torácica causada por enfermedad de Scheuermann Resultados de uma pesquisa sobre o tratamento da cifose torácica de Scheuermann Results of a survey on the treatment of thoracic Scheuermann´s kyphosis

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    Claudio Silveri

    2012-06-01

    Full Text Available OBJETIVO: Conocer que parámetros se deben considerar para encarar el tratamiento de la cifosis torácica causada por la enfermedad de Scheuermann. MÉTODO: Se realizó una recolección de informaciones consistente en aplicar un cuestionario a 25 informantes calificados, colegas de diferentes países de Íbero/Latinoamérica miembros de SILACO (Sociedad Íbero/Latinoamericana de Columna y se analizaron los resultados de las mismas. RESULTADOS: Como tratamiento ortopédico, la mayoría se inclinó por el uso del corsé de Milwaukee, indicado en pacientes prepúberes y pospúberes con curvas mayores de 60º y en curvas de menos de 60º si tienen dolor. El tiempo de uso: 22 hrs por día, su mantenimiento hasta llegar a Risser 4 o 5. Se observó una tasa de abandono de 48% al plan terapéutico. En lo referente a tratamiento quirúrgico, las indicaciones surgen: por localización de la deformidad, el valor angular, dolor, edad y estética. La extensión del área a fusionar fue determinada con los espinogramas y radiografías dinámicas. Se eligió la vía posterior como vía de abordaje con barras y tornillos, y en algunos casos la combinación con ganchos. Se evaluaron los resultados del tratamiento quirúrgico (de acuerdo a la opinión del médico, que fueron catalogados como buenos en un 64%. CONCLUSIONES: Se realizó una encuesta de opinión sobre el tratamiento de la cifosis torácica causada por enfermedad de Scheuermann .y se analizaron 25 formularios de respuestas de calificados cirujanos de columna, de diferentes países de Ibero/Latinoamérica miembros de SILACO. La encuesta ha permitido establecer normas de conducta terapéuticas (ortopédicas y quirúrgicas para el tratamiento de esta afección.OBJETIVO: Obter os parâmetros a serem considerados para realizar o tratamento da cifose torácica de Scheuermann. MÉTODOS: Os dados foram obtidos por meio de um questionário que foi respondido por 25 membros da SILACO (Sociedad Ibero

  13. [Recent advances in gene therapy of uveitis].

    Science.gov (United States)

    Tao, Xue-ying; Yang, Pei-zeng; Lei, Bo

    2013-03-01

    Uveitis is a group of common eye disease and is one of the major causes of blindness worldwide. Corticosteroids and immunosuppressive agents are commonly used for the treatment of uveitis. However, long-term application of these drugs frequently lead to numerous side effects. Recently, with the development of gene transfer techniques, viral vector mediated gene therapy has achieved remarkable success in experimental uveitis. Inhibition of ocular inflammation in animal models is obtained mainly by two ways: first, increase of the expression of different immune modulators including IL-10, IL-1Ra, IL-4 and IFN-alpha, or IL-27p28; secondly, induction of immune tolerance by transferring uveitis related antigens via viral vectors. Uveitis is characterized by long-lasting and recurrent, the unique properties of local administration, long-term effectiveness and minor side effects of gene therapy may provide a novel strategy for the treatment of the devastating uveitis.

  14. Association of Psoriatic Disease With Uveitis

    DEFF Research Database (Denmark)

    Egeberg, Alexander; Khalid, Usman; Gislason, Gunnar Hilmar

    2015-01-01

    IMPORTANCE: Psoriasis, psoriatic arthritis, and uveitis are inflammatory disorders with significant overlap in their inflammatory pathways. Limited evidence is available about the relationship between psoriatic disease and uveitis. OBJECTIVE: To investigate the potential bidirectional relationship...... between psoriatic disease, including psoriasis and psoriatic arthritis, and uveitis. DESIGN, SETTING, AND PARTICIPANTS: We performed a nationwide cohort study of the Danish population from January 1, 1997, through December 31, 2011. We included 74,129 Danish patients with psoriasis who were 18 years......, 2015. EXPOSURES: Diagnosis of mild or severe psoriasis or psoriatic arthritis for uveitis risk and diagnosis of uveitis for the risk for psoriasis or psoriatic arthritis. MAIN OUTCOMES AND MEASURES: Diagnosis of uveitis, mild psoriasis, severe psoriasis, or psoriatic arthritis. We calculated incidence...

  15. Care of children with anterior uveitis.

    Science.gov (United States)

    Kanski, J J

    1981-09-01

    The clinical features of 290 children with anterior uveitis are presented. The vast majority suffered from chronic uveitis. Specific uveitis entities in children include the syndrome of 'chronic iridocyclitis' in girls, heterochromic cyclitis, and pars planitis. Systemic associations include sarcoidosis, the Vogt-Harada-Koyanagi syndrome, and the seronegative arthritides (juvenile chronic arthritis, juvenile ankylosing spondylitis, psoriatic arthritis, and rarely Reiter's and Beçet's syndromes). Children with a pauciarticular onset of juvenile chronic arthritis, especially when combined with positive findings for antinuclear antibody, are at particular risk of developing chronic anterior uveitis. Most cases of chronic anterior uveitis can be controlled with topical corticosteroids. Those that are resistant to both topical and systemic corticosteroids may have to be treated with chlorambucil. The operation of lensectomy is a great advance in the management of complicated cataract. Secondary glaucoma is the most devastating complication of chronic anterior uveitis in children and responds poorly to therapy.

  16. Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China

    NARCIS (Netherlands)

    Yang, P.; Zhang, Z.; Zhou, H.; Li, B.; Huang, X.; Gao, Y.; Zhu, L.; Ren, Y.; Klooster, J.; Kijlstra, A.

    2005-01-01

    Purpose: To address the clinical pattern and characteristics of uveitis in a tertiary center for uveitis in China and compare the similarity and difference in the distribution of uveitis entities between China and other countries. Methods: A retrospective study was performed on the patients with uve

  17. Recent advances in managing and understanding uveitis

    Science.gov (United States)

    Chen, Shih-Chou; Sheu, Shwu-Jiuan

    2017-01-01

    Uveitis is a sight-threatening disease entity with intraocular inflammation that arises from various causes. It mainly affects working-age individuals and may lead to irreversible visual loss if not treated properly in a timely manner. This article reviews recent advances in the management and understanding of uveitis since 2014, including treatment with new immunosuppressive therapies that use biological agents, local therapy with steroid implants, and imaging studies for the evaluation of uveitis. PMID:28357059

  18. Alteraciones dentales y periodontales causadas por el stripping en ortodoncia.

    OpenAIRE

    Aparicio Merchán, Helena

    2015-01-01

    Desde hace más de setenta años el desgaste interproximal o stripping forma parte de las opciones de las que disponemos en los tratamientos de ortodoncia. Inicialmente fue un procedimiento indicado solo para pacientes adultos principalmente para el tratamiento de las discrepancias dentarias y la prevención de las recidivas mediante la estabilización de los puntos de contacto. Además comenzó a emplearse como alternativa en los casos dudosos de extracción, la eliminación de triángulos n...

  19. Surto de mastite bovina causada por Arcanobacterium pyogenes

    Directory of Open Access Journals (Sweden)

    R.G. Motta

    2011-06-01

    Full Text Available An uncommon outbreak of mastitis caused by Arcanobacterium pyogenes in 26 cows is reported. The epidemiological findings, clinical signs, microbiological exams, somatic cell count, in vitro susceptibility profile of strains, efficacy of intramammary treatment and control measures were discussed. Florfenicol (96.2%, cefoperazona (92.3%, cefaloxin (84.6% and ceftiofur (84.6% were the most effective antimicrobials, and neomicin (27.0% and enrofloxacin (17.4% the least effective antimicrobials.

  20. Nucleotídeos na dieta de frangos de corte e seus efeitos sobre taxa de turnover da mucosa intestinal antes e após lesões causadas por coccidiose Nucleotides in broilers challenged diet and its effects on intestinal mucosa turnover rate before and after injuries caused by coccidiose

    Directory of Open Access Journals (Sweden)

    Vanessa Cristina Pelícia

    2011-09-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito da dieta suplementada com nucleotídeos sobre taxa de turnover da mucosa intestinal de frangos antes e após lesões causadas por coccidiose por meio de análise isotópica, utilizando a variação do carbono-13 em plantas C3 e C4. Foram utilizados 264 pintos submetidos a dois tratamentos: dieta controle e dieta suplementada com 0,07% nucleotídeos. Os pintos possuíam sinais isotópicos em seus tecidos semelhantes ao de ditas C4. Após o alojamento, para avaliar taxa de turnover da mucosa, as aves receberam dietas predominantemente C3. Com 16 dias de idade, 50% das aves de cada tratamento foram inoculadas com oocistos de Eimeria acervulina e, a partir de 21 dias, para avaliar a taxa de turnover após desafio, as aves passaram a receber dieta predominantemente C4. Amostras de mucosa foram analisadas isotopicamente por espectrometria de massa. Na fase inicial, a suplementação com nucleotídeos propiciou aceleração na troca do carbono na mucosa, com meia-vida de 1,06 e 1,01 dias para dieta controle e com nucleotídeos, respectivamente, acelerando o crescimento intestinal. Na fase de 21 a 42 dias de idade, para os grupos não desafiados com coccidiose, as meias-vidas do carbono foram 1,81 e 1,80 dias para dieta controle e com nucleotídeos, respectivamente, não havendo influência dos tratamentos. Porém, nos grupos desafiados, as meias-vidas foram 1,01 dias no grupo controle e 0,75 dias no que recebeu dieta com nucleotídeos, indicando maior turnover da mucosa nesse último grupo. A adição de nucleotídeos promove aceleração no processo de renovação da mucosa intestinal e na regeneração após danos causados por coccidiose.The objective was to evaluate the effect of nucleotides supplementation diet on the intestinal mucosa turnover rate of broilers before and after injury caused by coccidiosis, through isotopic analysis, using the carbon-13 variation in C³ and C4 plants. It was used 264

  1. Equine uveitis: a UK perspective.

    Science.gov (United States)

    Lowe, R C

    2010-03-01

    Uveitis in the equine population of the UK does not appear to be as prevalent or disastrous as seen across regions of Europe and the USA. Some cases perceived to be recurrent uveitis may be poorly resolved single episodes of uveitis and care should be taken not to make the diagnosis of recurrence without ensuring effective control of the initial episode. Leptospira spp. appear to play only a minor role ERU in the UK which is probably the main reason for the prevalence of the disease being much lower compared to the USA and mainland Europe. Actual data are relatively few on the ground as far as disease surveillance in concerned. This has 2 implications. Firstly unless we are able to effectively monitor the levels of uveitic disease, it will be difficult to pick up early changes in the trend which may allow quicker intervention. Secondly, it is difficult to secure funding for further research if the prevalence of the problem is poorly defined. This may leave the UK equine population at risk should the disease profile suddenly alter for the worse.

  2. Effect of topical 0.5% povidone-iodine compared to 5% natamycin in fungal keratitis caused by Fusarium solani in a rabbit model: a pilot study Efeito tópico de iodo-povidona 0,5% comparado com natamicina 5% em ceratites fúngicas causadas por Fusarium solani em um modelo animal de coelhos: estudo piloto

    Directory of Open Access Journals (Sweden)

    Lauro Augusto de Oliveira

    2008-12-01

    tratados por 3 dias e sacrificados em seguida. As córneas foram removidas cirurgicamente, maceradas e incubadas em meio BHI. Semeou-se culturas em placas de ágar Sabouraud, diariamente, durante 7 dias, e contou-se o número de unidades formadoras de colônias (UFC. Os coelhos foram avaliados clinicamente durante o período de tratamento. RESULTADOS: Os grupos iodo-povidona e natamicina demonstraram melhor eficácia do que o grupo controle considerando-se o número de coelhos nos quais não houve crescimento de colônias. Entretanto, não houve diferença estatística significante entre os 3 grupos quando se analizou o número de UFC (p>0,05. CONCLUSÃO: Este estudo demonstrou considerações metodológicas importantes na utilização de modelos animais para o teste de agentes antifúngicos. Usando a metodologia de contar UFC e com este tamanho amostral, administração tópica de iodo-povidona 0,5% não demonstrou benefício do tratamento de ceratite fúngica experimental causada por Fusarium solani quando comparado com a administração tópica de natamicina 5%.

  3. Perspectives for uveitis treatment in rheumatic diseases

    Directory of Open Access Journals (Sweden)

    Alla Aleksandrovna Godzenko

    2011-01-01

    Full Text Available The paper describes current approaches to treating uveitis in rheumatic diseases and theoretical backgrounds for using tumor necrosis factor-α (TNF-α inhibitors. The data available in the literature suggest that anti-TNF-α therapy is highly effective in relieving and preventing uveitis attacks.

  4. Uveitis in Children: Diagnosis and Management.

    Science.gov (United States)

    Gupta, Anju; Ramanan, A V

    2016-01-01

    Uveitis is a term used to describe inflammation of uvea, which is the middle layer of eye. It is an important cause of blindness in children in both developed and developing countries. Delayed diagnosis, inadequate treatment and risk of amblyopia are some of the factors that are unique to childhood uveitis and are responsible for significant morbidity seen with this disease.

  5. Contribuição das projeções oblíquas em mielografias de pequenos animais para a localização de lesões medulares causadas por processo degenerativo do disco intervertebral Contribution of oblique projections in small animals myelography to the localization of spinal lesions caused by intervertebral disc degeneration

    Directory of Open Access Journals (Sweden)

    Karen Maciel Zardo

    2010-11-01

    Full Text Available Mielografia é uma técnica radiográfica na qual se administra meio de contraste no espaço subaracnóideo para avaliar a medula espinhal. Múltiplas projeções radiográficas fornecem uma exploração circunferencial da medula, auxiliando na localização mais precisa de compressões nesta região. Objetivou-se demonstrar a contribuição das projeções oblíquas, pouco exploradas em exames de mielografia, para a localização de lesões medulares extradurais em cães e gatos causadas por processo degenerativo do disco intervertebral. Foram avaliadas 116 mielografias e observou-se que em 36,2% dos casos as projeções oblíquas foram imprescindíveis para a localização exata das lesões. A associação entre as projeções ventrodorsal e oblíquas se mostraram mais úteis para a localização da lesão do que quando avaliadas isoladamente e as projeções oblíquas esquerda e direita foram igualmente importantes.Myelography is a radiographic technique in which is administered contrast in the subarachnoid space to assess the spinal cord. Multiple radiographic projections provide a circumferential view of the spinal cord, aiding in more precise localization of compression in this region. This paper aimed to demonstrate the contribution of oblique projections, little explored in myelography, for the location of extradural spinal cord injuries in dogs and cats caused by degeneration of the intervertebral disc. It was evaluated 116 myelography and it was observed that in 36.2% of cases, oblique views were essential to the exact localization of lesions. The association between the oblique and ventrodorsal projections was more effective to find the lesion´s lateralization than when taken separately, and the left and right oblique view was equally important.

  6. Intermediate uveitis, posterior uveitis, and panuveitis in the Mid-Atlantic USA

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    Engelhard SB

    2015-08-01

    Full Text Available Stephanie B Engelhard, Vandan Patel, Ashvini K Reddy Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA Background: The purpose of this study was to identify the causes, clinical features, and outcomes of intermediate uveitis, posterior uveitis, and panuveitis in patients managed in a mid-Atlantic tertiary care center.Methods: This was a retrospective observational study of intermediate uveitis, posterior uveitis, and panuveitis patients seen at the University of Virginia from 1984 to 2014. Results: One hundred and fifty-nine intermediate uveitis, posterior uveitis, and panuveitis patients (237 eyes were identified. The patient population was 54.72% female; 67.30% of patients were Caucasian, and 22.01% were African–American. Mean age at diagnosis was 45.5 years. Mean duration of follow-up was 3.95 years. Mean number of visits to the clinic was 10.35. Of 491 uveitis patients, 26 (5.30% had intermediate uveitis, 62 (12.60% had posterior uveitis, and 71 (14.50% had panuveitis. The leading diagnoses in the intermediate uveitis group were pars planitis (73.08% and sarcoidosis (11.54%; toxoplasma uveitis (17.74%, multifocal choroiditis (14.52%, undifferentiated posterior uveitis (14.52%, and birdshot chorioretinitis (11.29% in the posterior uveitis group; and undifferentiated panuveitis (29.58%, post-surgical panuveitis (18.31%, sarcoidosis (12.68%, acute retinal necrosis (12.68%, and toxoplasma uveitis (4.23% in the panuveitis group. The most common treatment modalities included local steroids (57.23% and systemic steroids (42.14%. Ocular hypertension was found in 38 patients (23.90%. Glaucoma surgery was performed in 18.24% of patients and cataract surgery in 21.38%. Mean best-corrected visual acuity was 0.66 logMAR at baseline across all anatomical locations and 0.57 logMAR at final follow-up. Best-corrected visual acuity improved or remained stable during follow-up in all groups. Conclusion: The most common diagnoses

  7. Current approach in diagnosis and management of anterior uveitis

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    Agrawal Rupesh

    2010-01-01

    Full Text Available Uveitis is composed of a diverse group of disease entities, which in total has been estimated to cause approximately 10% of blindness. Uveitis is broadly classified into anterior, intermediate, posterior and panuveitis based on the anatomical involvement of the eye. Anterior uveitis is, however, the commonest form of uveitis with varying incidences reported in worldwide literature. Anterior uveitis can be very benign to present with but often can lead to severe morbidity if not treated appropriately. The present article will assist ophthalmologists in accurately diagnosing anterior uveitis, improving the quality of care rendered to patients with anterior uveitis, minimizing the adverse effects of anterior uveitis, developing a decision-making strategy for management of patients at risk of permanent visual loss from anterior uveitis, informing and educating patients and other healthcare practitioners about the visual complications, risk factors, and treatment options associated with anterior uveitis.

  8. Surtos epidêmicos de dermatite causada por mariposas do gênero Hylesia (Lepidóptera: Hemileucidae no Estado de São Paulo, Brasil Epidemic outbreaks of dermatitis caused by Hylesia (Lepidoptera: Hemileucidae, in S. Paulo State, Brazil

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    Carmen Moreno Glasser

    1993-06-01

    Full Text Available Surtos epidêmicos de dermatite causada por Hylesia sp foram assinalados no litoral do Estado de São Paulo, no período de dezembro de 1989 a dezembro de 1991. O fenômeno assumiu sua maior intensidade em Bertioga, Município de Santos, onde foram registrados 612 casos. Foram atingidos outros 12 municípios da região, estimando-se que algumas centenas de casos procuraram os serviços de saúde locais. Na maioria dos casos verificou-se lesões eritemato-pápulo-pruriginosas, que regrediram em média de 7 a 14 dias. Para tratamento foram utilizados anti-histamímicos sistêmicos corticosteróides tópicos e compressas frias. Ocorreram três episódios epidêmicos no período citado, todos eles coincidindo com o início da estação chuvosa (novembro a janeiro. A cada episódio verificou-se um deslocamento do fenômeno no sentido Norte-Sul. A principal medida profilática utilizada foi a divulgação, junto à população, das medidas de redução de exposição ao agente. Para prédios com elevada infestação por mariposas, foi estudada a efetividade da aplicação de inseticida residual, como medida de redução dos níveis de infestação por mariposas. Obteve-se resultados satisfatórios com deltametrina na dose de 50 mg/m² de parede.Epidemic outbreaks of dermatitis caused by Hylesia sp wich occurred in the coastal region of the State of S. Paulo during the period of December 1989 to December 1991 are confirmed. The incident assumed its greatest intensity in Bertioga, in Santos County, where 612 cases were registered. The outbreak also affected 12 other counties in that region and it was estimated that hundred of affected persons sought the Local Health Service Care. The majority presented with erythematous and prutiginous lesions and papula which lasted 7 to 14 days on average. Treatment consisted of systemic administration of antihistamines, and the use of topic corticosteroides and cold compresses. During the abovementioned period, three

  9. Prevalence and clinical impact of antiretinal antibodies in uveitis

    OpenAIRE

    Ten Berge, Josianne C.E.M.; Schreurs, Marco W.; Vermeer, Jacolien; Meester-Smoor, Magda; Rothova, Aniki

    2016-01-01

    textabstractPurpose: To determine the prevalence of serum antiretinal antibodies (ARAs) among patients with uveitis and establish their clinical relevance. Methods: This prospective study assessed the presence of ARAs by indirect immunofluorescence (IIF) using primate retina in 126 patients with uveitis and 60 healthy controls. Clinical data of uveitis patients were collected from medical charts and included the classification of uveitis, cause of uveitis or its association with systemic dise...

  10. Juvenile idiopathic arthritis-associated uveitis.

    Science.gov (United States)

    Clarke, Sarah L N; Sen, Ethan S; Ramanan, Athimalaipet V

    2016-04-27

    Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood, with JIA-associated uveitis its most common extra-articular manifestation. JIA-associated uveitis is a potentially sight-threatening condition and thus carries a considerable risk of morbidity. The aetiology of the condition is autoimmune in nature with the predominant involvement of CD4(+) T cells. However, the underlying pathogenic mechanisms remain unclear, particularly regarding interplay between genetic and environmental factors. JIA-associated uveitis comes in several forms, but the most common presentation is of the chronic anterior uveitis type. This condition is usually asymptomatic and thus screening for JIA-associated uveitis in at-risk patients is paramount. Early detection and treatment aims to stop inflammation and prevent the development of complications leading to visual loss, which can occur due to both active disease and burden of disease treatment. Visually disabling complications of JIA-associated uveitis include cataracts, glaucoma, band keratopathy and macular oedema. There is a growing body of evidence for the early introduction of systemic immunosuppressive therapies in order to reduce topical and systemic glucocorticoid use. This includes more traditional treatments, such as methotrexate, as well as newer biological therapies. This review highlights the epidemiology of JIA-associated uveitis, the underlying pathogenesis and how affected patients may present. The current guidelines and criteria for screening, diagnosis and monitoring are discussed along with approaches to management.

  11. Inefficacy of albendazole sulphoxide and ivermectin for the treatment of bovine parasitic otitis caused by rhabditiform nematodes Ineficácia do sulfóxido de albendazole e da ivermectina no tratamento da otite parasitária bovina causada por nematóides rhabditiformes

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    Guilherme G. Verocai

    2009-11-01

    Full Text Available The purpose of this study was to evaluate the efficacy of orally administered albendazole sulphoxide and pour-on ivermectin for the treatment of bovine parasitic otitis caused by rhabditiform nematodes. Eighteen Gyr cows presenting clinical otitis were divided in three groups with six animals each. The first one did not receive any treatment (control group. The second one was treated with 0.5% pour-on ivermectin, 500µg/kg of body weight, and the third group was treated with oral 6% albendazole sulphoxide, at 6.0mg/kg. Both ear canals of each animal were reexamined on days 7 and 21 post treatment. The animals in the control group remained infected throughout the days of observation. Ivermectin treatment did not show effectiveness on days 7 or 21 post treatment. The albendazole sulphoxide treatment had an efficacy of 16.7 and 25% on days 7 and 21, respectively. Further studies are required to assess an effective treatment for this parasitic disease, especially via alternative administration routes, because of its significant impact on Bos taurus indicus cattle breeding in Tropical and Subtropical Regions.O objetivo deste estudo foi avaliar a eficácia do sulfóxido de albendazol administrado oralmente e da ivermectina "pour-on" no tratamento da otite parasitária bovina causada por nematóides rhabditiformes. Dezoito vacas Gir apresentando otite clínica foram divididas em três grupos de seis animais cada. O primeiro não recebeu tratamento (grupo controle. O segundo foi tratado com ivermectina "pour-on" a 0,05% na dose de 500µg/kg de peso vivo. O terceiro grupo foi tratado com sulfóxido de albendazol oral a 6% na dose 6,0mg/kg. Os condutos auditivos de todos os animais foram reexaminados nos dias 7 e 21 pós-tratamento. Os animais do grupo controle permaneceram infectados nos dias de observação. O tratamento com ivermectina não demonstrou eficácia alguma para os dias 7 e 21 pós-tratamento. O tratamento com sulfóxido de albendazol obteve

  12. Efeitos do tratamento prévio com lidocaína, paracetamol e lidocaína-fentanil por via venosa na dor causada pela injeção de propofol: estudo comparativo Efectos del tratamiento previo con lidocaína, paracetamol y lidocaína-fentanil intravenosos en el dolor causado por la inyección de propofol: estudio comparativo Effect of pretreatment with lidocaine, intravenous paracetamol and lidocaine-fentanyl on propofol injection pain: comparative study

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    Khaled M. El-Radaideh

    2007-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Foi realizado estudo duplamente encoberto, aleatório, para avaliar a eficácia do tratamento prévio, por via venosa, com lidocaína, paracetamol (Perfalgan® ou lidocaína associada ao fentanil na redução da dor causada pela injeção de propofol. MÉTODOS: Imediatamente após a oclusão venosa com torniquete de borracha foi feita a administração venosa de 4 mL de lidocaína a 1% (Grupo L, n = 50, 4 mL de paracetamol (Perfalgan® (40 mg (Grupo R, n = 50, lidocaína a 2% associada a 100 µg de fentanil (Grupo LF, n = 50 ou 4 mL de solução fisiológica a 0,9% (Grupo P, n = 50; grupo-controle com placebo a 200 adultos. A liberação da obstrução venosa foi feita após 60 segundos, sendo seguida da administração venosa de propofol, 2,5 mg.kg-1 a uma velocidade de 0,5 mg.s-1 através de cateter 20G inserido na veia do dorso da mão. A avaliação da dor foi feita durante a injeção de propofol. Ela incluiu movimentos da mão, expressão verbal espontânea de dor, caretas e gemidos durante a injeção de propofol. RESULTADOS: Lidocaína-fentanil (70% sem dor e lidocaína (68% sem dor foram mais eficazes na redução da dor causada pela injeção de propofol do que o paracetamol (54% sem dor e o placebo (36% sem dor (p JUSTIFICATIVA Y OBJETIVOS: Se realizó estudio doblemente encubierto, aleatorio, para evaluar la eficacia del tratamiento previo, intravenoso (IV, con lidocaína, paracetamol (Perfalgan® o lidocaína asociada con fentanil en la reducción del dolor causado por la inyección de propofol. MÉTODOS: Inmediatamente después de la oclusión venosa con un torniquete de goma, se hizo la administración intravenosa de 4 mL de lidocaína a 1% (Grupo L, n = 50, 4 mL de paracetamol (Perfalgan® (40 mg (Grupo R, n = 50, lidocaína a 2% asociada con 100 µg de fentanil (Grupo LF, n = 50 o 4 mL de solución fisiológica (Grupo P, n = 50; grupo control con placebo a 200 adultos. La liberación de la obstrucci

  13. Uveitis in Spondyloarthritis: An Overview.

    Science.gov (United States)

    Cantini, Fabrizio; Nannini, Carlotta; Cassarà, Emanuele; Kaloudi, Olga; Niccoli, Laura

    2015-11-01

    Autoimmune anterior uveitis (AU) accounts for at least half of the cases of noninfectious uveitis, and similarly to spondyloarthritis (SpA), its occurrence is related to HLA-B27 positivity. AU is significantly more frequently found in HLA-B27-positive subjects with SpA and is characterized by unilateral eye involvement, marked tendency to recur with involvement of both eyes in alternate fashion, and has good prognosis in the majority of cases. The estimated frequency of SpA in patients with AU is around 50%, whereas AU in SpA has been reported in at least 30% of cases. Across the SpA disease spectrum, AU has a frequency peak of 33.4% in patients with ankylosing spondylitis, while the estimated prevalence in psoriatic arthritis (PsA) and inflammatory bowel disease-associated SpA is 2%-25%, and 25%, respectively. In early PsA, the frequency of AU has been found in 9% of patients. The wide range of prevalence reported in PsA may be explained by the variable sets of classification criteria used for patient selection and the different length of followup. AU may precede the clinical features of SpA, may be present at diagnosis, or may complicate the SpA clinical course. However, the occurrence of AU in SpA as well as AU flares has been reduced through treatment of SpA with anti-tumor necrosis factor-α agents.

  14. Unilateral subretinal fibrosis and uveitis syndrome.

    Science.gov (United States)

    Rehan, S; Javaid, Z; Al-Bermani, A

    2015-05-01

    Subretinal fibrosis and uveitis syndrome is a rare, potentially devastating, posterior uveitis of unknown aetiology, characterised bilaterally by initial multifocal choroiditis with later progressive subretinal fibrosis. We report a rare case of unilateral subretinal fibrosis and uveitis syndrome. To date, there are only two case reports of unilateral disease. Our patient presented with unilateral blur and was found to have reduced visual acuity. A Bartonella profile was positive and a diagnosis of Bartonella posterior uveitis was made. Several positive ocular findings in the anterior chamber and on fundoscopy consistent with the syndrome were found. When steroid therapy alone could no longer control active inflammation, the immunosuppressive agent mycophenolate was added. Over time subretinal fibrosis became established sparing the macula and associated complications occurred, but with mycophenolate, at four years, our patient's visual acuity had improved and remains stable. Moreover, four years after her initial presentation, her condition remains strictly unilateral.

  15. Anterior uveitis in juvenile rheumatoid arthritis.

    Science.gov (United States)

    Kanski, J J

    1977-10-01

    The ocular and systemic characteristics of 160 patients with anterior uveitis and seronegative juvenile rheumatoid arthritis are reviewed. Chronic uveitis occurred in 131 patients, 76% of whom were girls. Both eyes were involved in 70% of the cases. Band keratopathy occurred in 41% of the eyes, cataract in 42%, and secondary glaucoma in 19%. Only 11 patients had uveitis before the onset of arthritis. Notable correlations included a pauciarticular onset of arthritis in 95% of the patients, and positive tests for antinuclear antibody in 82%. Of 29 patients with acute anterior uveitis, 27 were boys. The inflammation responded well to therapy, and serious complications did not occur. At follow-up 21 patients had typical ankylosing spondylitis, and five had sacroiliitis. The incidence of positive results of tests for HLA-B27 antigen was 94%.

  16. The Use of Biologic Therapies in Uveitis.

    Science.gov (United States)

    Schwartzman, Sergio; Schwartzman, Monica

    2015-12-01

    Therapy for autoimmune ophthalmic disease is currently evolving. The improved understanding of the abnormal immune response in the various forms of uveitis has resulted in targeted therapy. The aberrations of the immune system have been characterized by atypical cell populations, cytokine expression, and cell-cell interactions. Different patterns of cytokine expression have now been delineated in the abnormal uveal tract with exaggerated and/or abnormal expression of TNF, IL-1, IL-2, IL-6, and IL-17. The development of therapies for other conditions in which these cytokines play an important role has resulted in the availability of biological agents that have been adopted for use in the therapy for uveitis. Adalimumab and infliximab have been the best studied anti-TNF agents and indeed have now been recommended by an expert panel as first-line treatment of ocular manifestations of Behçet's disease and second-line treatment for other forms of uveitis (Levy-Clarke et al. (Ophthalmology, 2013). Other anti-TNF agents have been studied as well. Daclizumab, a monoclonal antibody directed against the IL-2 receptor, has also demonstrated utility in treating uveitis as have some of the anti-IL1 agents. Gevokizumab has been granted orphan drug designation for the treatment of resistant forms of uveitis. Therapies affecting IL-6, including tocilizumab are being studied, and available medications that block antigen presenting cell and T cell interaction such as abatacept have been reported to be effective in uveitis. Interferons as well as rituximab have also been evaluated in small studies. Although these biologic therapies have provided a larger armamentarium to treat uveitis, challenges remain. Uveitis is not a single illness; rather, it is a manifestation of many potential systemic diseases that may have very specific individual therapeutic targets. Identifying and characterizing these underlying diseases is not always achieved, and more importantly, the most effective

  17. Clinical Characteristics of Fuchs’ Uveitis Syndrome

    OpenAIRE

    2016-01-01

    Objectives: To evaluate the clinical and demographic properties of Fuchs’ uveitis syndrome (FUS) in Turkish patients. Materials and Methods: The medical records of 161 patients with FUS followed in the Uveitis Division of Ulucanlar Eye Hospital between 1996 and 2014 were respectively reviewed. The mean age at diagnosis, sex, the number of affected eyes, follow-up period, clinical findings at presentation, complications during the follow-up period, medical and surgical treatments, and best cor...

  18. Clinical Characteristics of Fuchs’ Uveitis Syndrome

    OpenAIRE

    2016-01-01

    Objectives: To evaluate the clinical and demographic properties of Fuchs’ uveitis syndrome (FUS) in Turkish patients. Materials and Methods: The medical records of 161 patients with FUS followed in the Uveitis Division of Ulucanlar Eye Hospital between 1996 and 2014 were respectively reviewed. The mean age at diagnosis, sex, the number of affected eyes, follow-up period, clinical findings at presentation, complications during the follow-up period, medical and surgical treatments, and...

  19. Causes of visual loss in uveitis

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    Stanković Zora

    2009-01-01

    Full Text Available Background/Aim. Epidemiological studies of blindness in a working age population require a precise definition of the true connection of uveitis and visual damage. Since most patients with more severe types of uveitis are hospitalized in tertiary referral uveitis service, our aim was to determine whether age, sex and age of onset of uveitis, as well as duration of visual loss and its causes influence the degree of visual damage in patients with different types of uveitis. Methods. The data were collected from medical records of 237 patients at the Department for Uveitis of the Institute for Eye Diseases in Belgrade over a three-year period (March 2005 to March 2008. Results. Visual acuity reduction (≤ 0.3 was found in 161/237 (67.9% patients, 85 of whom had visual acuity of ≤ 0.1 later. Working age patients (up to 60 years of age most often suffered from uveitis (173/237; 73%. The highest number of patients with visual loss was in the group suffering from panuveitis (77/94; 81.91%. The age of onset of uveitis and sex have no statistically significant influence on visual loss. The most common causes of visual loss (34/161; 21.1% were cystoid macular oedema (CMO (43/161; 26.7%, cataract (28/161; 17.39% and combination of CMO and cataract. Conclusion. The risk factors for severe visual loss (≤ 0.1 are panuveitis, bilateral inflammation, prolonged visual reduction and a significant number of relapses. The main causes of visual loss in 65.2% of our patients were CMO and cataract.

  20. Utilização da vacina Escherichia coli J5 na imunização de vacas leiteiras contra mastites causadas por E. coli Use of an Escherichia coli J5 vaccine on immunization of dairy cows against mastitis caused by E. coli

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    Lívio R. Molina

    2013-03-01

    Full Text Available Avaliou-se a utilização da vacina Escherichia coli J5, na imunização de vacas leiteiras, para prevenção e controle da mastite causada por E. coli através da análise da prevalência das infecções intramamárias (IMM no pós-parto, ocorrência e intensidade dos casos clínicos de mastite nos primeiros 100 dias de lactação, influência na contagem de células somáticas (CCS e produção de leite. O grupo experimental foi composto de 187 animais, divididos em 2 grupos, vacas vacinadas e não vacinadas. As imunizações ocorreram 60 dias antes do parto, 30 dias antes do parto e na primeira semana pós-parto. No dia da secagem e sete dias após o parto foram coletadas amostras para diagnóstico microbiológico dos patógenos causadores de mastite. A ocorrência de casos clínicos foi verificada pelo teste da caneca durante as ordenhas sendo registrados os dados relacionados à intensidade. Amostras foram coletadas mensalmente, a partir do décimo dia de lactação, para avaliação da CCS. A produção de leite foi registrada mensalmente nos primeiros 100 dias de lactação. Verificou-se no grupo vacinado, redução na prevalência de E. coli no pós-parto, na ocorrência de casos clínicos por E.coli nos primeiros 100 dias de lactação bem como na intensidade destes casos clínicos. Não foram observadas diferenças estatísticas significativas na CCS, entretanto vacas vacinadas apresentaram maior produção de leite, comparadas às vacas não vacinadas. A vacinação com E. coli J5 foi eficaz em reduzir a prevalência de infecções intramamárias (IMM ao parto, ocorrência e intensidade dos casos clínicos e aumento na produção de leite nos primeiros 100 dias de lactação.We evaluated the use of Escherichia coli J5 vaccine immunization in dairy cows for the prevention and control of mastitis caused by E. coli. Were analyzed the prevalence of postpartum intramammary infections (IMM, occurrence and severity of clinical cases of

  1. New Immunosuppressive Therapies in Uveitis Treatment

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    Salvador Mérida

    2015-08-01

    Full Text Available Uveitis is an inflammatory process that initially starts in the uvea, but can also affect other adjacent eye structures, and is currently the fourth cause of blindness in developed countries. Corticoids are probably the most widespread treatment, but resorting to other immunosuppressive treatments is a frequent practice. Since the implication of different cytokines in uveitis has been well demonstrated, the majority of recent treatments for this disease include inhibitors or antibodies against these. Nevertheless, adequate treatment for each uveitis type entails a difficult therapeutic decision as no clear recommendations are found in the literature, despite the few protocolized clinical assays and many case-control studies done. This review aims to present, in order, the mechanisms and main indications of the most modern immunosuppressive drugs against cytokines.

  2. Follow-up of erlotinib related uveitis

    Science.gov (United States)

    Kumar, Indu; Ali, Kashif; Usman-Saeed, Muniba; Saeed, Muhammad Usman

    2012-01-01

    The authors report the follow-up of a 68-year-old lady with bilateral anterior uveitis secondary to erlotinib. Erlotinib was started and stopped after symptoms and signs suggestive of severe bilateral anterior uveitis were noted. The patient developed signs of a non-ST elevation myocardial infarction, 12 days after stopping the erlotinib, and recovered without major problems. The patient also reported intermittent low-grade fever since starting erlotinib which resolved after stopping this drug. No further symptoms of uveitis were noted up to 6 month follow-up. The patient reported improved well being, resolution of ocular symptoms and intermittent low-grade fever at last follow-up (6 months after stopping erlotinib). PMID:22892235

  3. Equine recurrent uveitis: Human and equine perspectives.

    Science.gov (United States)

    Malalana, Fernando; Stylianides, Amira; McGowan, Catherine

    2015-10-01

    Equine recurrent uveitis (ERU) is a spontaneous disease characterised by repeated episodes of intraocular inflammation. The epidemiology of ERU has not been fully elucidated, but the condition appears to be much more common in horses than is recurrent uveitis in humans, especially in certain breeds and geographical regions. Both humans and horses show a similarly altered immune response and a marked autoimmune response as the primary disease pathophysiology. However, an inciting cause is not always clear. Potential inciting factors in horses include microbial agents such as Leptospira spp. Microbial factors and genetic predisposition to the disease may provide clues as to why the horse appears so susceptible to this disease. The aim of this review is to discuss the immunology and genetics of ERU, compare the disease in horses with autoimmune anterior uveitis in humans, and discuss potential reasons for the increased prevalence in the horse.

  4. Dermatoses provocadas por plantas (fitodermatoses Dermatosis due to plants (phytodermatosis

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    Vitor Manoel Silva dos Reis

    2010-08-01

    Full Text Available As dermatoses causadas por plantas são relativamente comuns no nosso meio e podem ocorrer por diversos mecanismos patogênicos. São descritas dermatoses por trauma físico, por ação farmacológica, mediadas por IgE, por irritação, por ação conjunta da luz e por sensibilização. Também são descritas na introdução desta revisão as pseudofitodermatoses causadas por elementos veiculados pelas plantas e, por isso, aparentemente causadas pelas plantas.Dermatosis caused by plants is relatively common and may occur by various pathogenic mechanisms. Dermatitis due to physical trauma, pharmacological action, irritation, sensitization, mediated by IgE and induced by light are described. Pseudophytodermatosis caused by plant-delivered elements is also described in the introduction to this work.

  5. Uveitis in adults: What do rheumatologists need to know?

    Science.gov (United States)

    Sève, Pascal; Kodjikian, Laurent; Adélaïde, Léopold; Jamilloux, Yvan

    2015-10-01

    Rheumatologists may need to establish the etiological diagnosis and handle the therapeutic management of adults with uveitis. To date, no diagnostic strategy for uveitis has been validated by prospective studies. Investigations are selected based on the clinical features and on the anatomic location of the ocular abnormalities. Infections such as syphilis, Lyme disease, tuberculosis, and Whipple's disease may cause uveitis, with concomitant joint inflammation in a few cases. In patients with a known history of chronic inflammatory joint disease, causes of uveitis include bisphosphonate therapy and immunodepression-related infections (e.g., due to Toxoplasma or a herpes virus). Sarcoidosis is an underestimated cause of uveitis, which occurs in 15% of cases, with a predilection for middle-aged women. In spondyloarthritis, uveitis is almost always acute, unilateral, and anterior. Among patients with uveitis and spondyloarthritis, about two thirds have their joint disease diagnosed during an evaluation for uveitis. Therefore, patients with inflammatory or noninflammatory back pain should be routinely evaluated for spondyloarthritis, which is the leading cause of uveitis in western countries. The risk of blindness is extremely low, and the main complication is recurrent uveitis, seen in 50% to 60% of cases. Sulfasalazine decreases the frequency, duration, and severity of uveitis and can be used prophylactically.

  6. Reação de híbridos, linhagens e progênies de pimentão à requeima causada por Phytophthora capsici e ao mosaico amarelo causado por Pepper yellow mosaic vírus (PepYMV Reaction of hybrids, lines and progenies of sweet pepper the blight caused by Phytophthora capsici and to Pepper yellow mosaic virus (PepYMV

    Directory of Open Access Journals (Sweden)

    Ildon Rodrigues do Nascimento

    2007-02-01

    Full Text Available A requeima do pimentão (Capsicum annuum L. causada por Phytophthora capsici e o mosaico amarelo causado por PepYMV são prioridades nos programas de melhoramento de pimentão em andamento no Brasil. Foram avaliados três híbridos comerciais (Magali R, Atenas F1 e Fortuna Super F1, cinco linhagens, 20 híbridos experimentais e duas progênies F2:4 do programa de melhoramento da Universidade Federal de Lavras/HortiAgro Sementes quanto à reação a P. capsici e a PepYMV. Os experimentos foram montados independentemente em blocos casualizados, com quatro e duas repetições, respectivamente. Cada parcela foi constituída de oito plantas instaladas em bandejas de 128 células, que foram mantidas em estufa com cobertura plástica e laterais teladas. As avaliações foram feitas do 4º ao 14º e do 15º ao 40º dias após a inoculação (DAI para P. capsici e PepYMV, respectivamente. A inoculação com P. capsici foi feita pormeio da distribuição de 5 mL de suspensão com 10(4 zoósporos/mL no solo ao redor do colo de cada planta. A inoculação mecânica de PepYMV foi feita a partir de macerados de folhas de Nicotiana tabacum cv. TNN, previamente infectadas. Os híbridos Magali R e Fortuna Super, foram suscetíveis a P. capsici, enquanto que o acesso Criollo de Morellos 334, a linhagem PIM-013 e as progênies PIX-03 pl#03-2 e PIX-030 pl#06-3 (ambas originadas do cruzamento com Criollo de Morellos, foram resistentes. Reação de resistência a P. capsici foi também observada para os híbridos experimentais que tiveram PIM-013 como uma das linhagens parentais. Criollo de Morellos 334, as progênies PIX-03 pl#03-2 e PIX-030 pl#06-3, o híbrido comercial Magali R e outros 6 híbridos experimentais que tinham como um dos genitores a linhagem MYR-29 forma ressitentes ao PepYMV. As progênies PIX-03 pl#03-2 e PIX-030 pl#06-3 são fontes promissoras de resistência a ambos os patógenos para serem desenvolvidas e exploradas em programas de melhoramento

  7. Study of aqueous humour in anterior uveitis

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    Kalsy Jairaj

    1990-01-01

    Full Text Available Aetiological diagnosis of anterior uveitis was made clinically and substantiated with relevant investigations. Aqueous humour obtained under aseptic conditions, was analyzed for the cells study, culture and protein profile, using polyacrylamide gel electrophoresis. The results were analysed with the help of known clinical facts. Culture and smears were invariably negative, while the lymphocytes were present in varying numbers, polymorphs and macrophages afforded a useful clue for confirmatory diagnosis. The electrophoretic pattern of the proteins was related to the duration of the disease and was same in a group while it was distinctive among different groups of anterior uveitis.

  8. A systematic approach to emergencies in uveitis

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    Hassan A. Al-Dhibi

    2014-01-01

    Full Text Available Uveitis is a common cause of preventable blindness although it is consider a sight-threatening condition particularly in cases with posterior segment inflammation. To deal with emergency conditions in uveitis, we must aware of the essential signs and symptoms that reflect a true uveitic emergency. Failure to recognize these essential signs and symptoms of a true uveitic emergency may result in a devastating visual outcome. This review provides general ophthalmologists and residents, clinical guidelines for the main uveitic entities that require immediate recognition and urgent intervention in the emergency room to prevent severe permanent visual loss.

  9. Terapia de resgate com amiodarona em crianças com grave disfunção ventricular esquerda causada por veneno de escorpião Terapia de rescate con amiodarona en niños con severa disfunción ventricular izquierda ocasionada por veneno de escorpión Antiadrenergic rescue therapy with amiodarone in children with severe left ventricular dysfunction secondary to scorpion envenomation

    Directory of Open Access Journals (Sweden)

    Justo J. Santiago

    2010-01-01

    Full Text Available FUNDAMENTO: As crianças picadas por escorpião, pressintam ativação maciça do sistema nervoso simpática com vários graus de disfunção sistólica ventricular esquerda. OBJETIVO: Testar um protocolo de resgate em crianças com grave disfunção ventricular esquerda causada por picada de escorpião. Métodos: Quatro crianças após serem picadas por escorpião foram submetidas a: Encubação endotraqueal e suporte respiratório, eletrocardiograma, radiografia de tórax, ecocardiograma e determinação sérica da norepinefrina e troponina I. As análises foram repetidas após 12, 24 e 48 horas. As seguintes medicações intravenosas foram administradas: dobutamina 4-6 μg/kg/min; amiodarona 3 mg/kg durante duas horas, com dose de manutenção de 5 mg/kg/dia; e furosemida 0,5 mg/kg. Amiodarona, dobutamina e furosemida foram administradas durante as primeiras 48 horas. Bloqueadores beta-adrenérgicos e inibidores da enzima conversora da angiotensina foram administrados até 48 após a internação, uma vez que o estado clínico havia melhorado e a fração de ejeção ventricular esquerda encontrava-se acima de 0,35%. RESULTADOS: Na admissão, a dosagem da norepinefrina foi 1.727,50± 794,96 pg/ml, a de troponina I 24,53 ± 14,09 ng/ml e a fração de ejeção do ventrículo esquerdo foi 0,20 ± 0,056. Após 12 horas, os níveis séricos de norepinefrina e de troponina I diminuíram para a metade dos valores iniciais e a fração de ejeção aumentou para 0,32 ± 0,059. Durante as 24 e 48 horas subseqüentes, a fração de ejeção elevou-se para 0,46 ± 0,045 (pFUNDAMENTO: Los niños con picaduras de escorpión sufren activación masiva del sistema nervioso simpático con varios grados de disfunción sistólica ventricular izquierda. OBJETIVO: Probar un protocolo de rescate en niños con disfunción ventricular severa izquierda ocasionada por picadura de escorpión. MÉTODOS: Cuatro niños tras un escorpión picarlas se sometieron a: incubaci

  10. Human cutaneous leishmaniasis caused by Leishmania (Viannia braziliensis in Santiago del Estero, Argentina: identification of parasites by monoclonal antibodies and isoenzymes Leishmaniose cutânea humana causada por Leishmania (Viannia braziliensis na Província de Santiago del Estero, Argentina: identificação dos parasitas por anticorpos monoclonais e isoenzimas

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    C.A. Cuba Cuba

    1996-12-01

    pacientes humanos com lesões cutâneas de leishmaniose na Província de Santiago del Estero, no Norte da Argentina. Os procedimentos de diagnóstico foram: biópsias de lesões para utilização em esfregaços e inoculação em hamster; aspiração (com agulha de úlceras, para cultura "in vitro". As técnicas imunodiagnósticas empregadas foram a IFAT-IgG e o teste intradérmico de Montenegro. Oito cepas de parasitas foram isoladas, sendo estas obtidas de pacientes com lesões ativas. Todas as cepas foram inicialmente caracterizadas biologicamente por seu comportamento na infecção experimental do hamster, mensuração dos amastigotas e promastigotas e crescimento "in vitro". As mesmas oito cepas foram logo identificadas e caracterizadas a nível de espécie, devido a sua reatividade frente a um painel de anticorpos monoclonais subgênero e espécie-específicos. Isso foi realizado utilizando o teste de Imunofluorescência Indireta (IFAT/MAbs e de um procedimento de Dot-ELISA. Nós concluímos a partir da análise de serodema dos isolados argentinos que: MHOM/AR/92/SE-1; SE-2; SE-4; SE-8; SE-8-I; SE-30; SE-34 e SE-36 são Leishmania (Viannia braziliensis. Entretanto, três dos isolados de Leishmania (SE-1; SE-2 e SE-30 não foram reconhecidos quando testados com um anticorpo monoclonal de reconhecida alta espécie-especificidade (clone B-18, marcador consagrado de Leishmania (Viannia braziliensis, revelando a existência de dois tipos de serodemas entre as cepas estudadas. Cinco dos oito extratos solúveis de Leishmania foram submetidos à eletroforese em gel de amido de camada fina e subseqüentemente examinadas a fim de constatar a atividade das enzimas MPI, MDH, 6PGD, NH, NH-D, SOD, GPI e ES. Fundamentados nos estudos dos corridos eletroforéticos obtidos nos ensaios isoenzimáticos chegamos à conclusão que as cepas MHOM/AR/92 SE-1; SE-2; SE-4; SE-8 e SE-8-I são Leishmania (Viannia braziliensis. É necessário analisar mais enzimas antes de enquadrá-los nos

  11. Managing juvenile idiopathic arthritis-associated uveitis.

    Science.gov (United States)

    Hawkins, Madeleine J; Dick, Andrew D; Lee, Richard J W; Ramanan, Athimalaipet V; Carreño, Ester; Guly, Catherine M; Ross, Adam H

    2016-01-01

    Bilateral chronic anterior uveitis is an extra-articular feature of juvenile idiopathic arthritis. Although figures vary, uveitis occurs in approximately 11%-13% of patients with this disease and is most commonly associated with the female gender, oligoarthritis, and presence of antinuclear antibodies. The disease has an insidious onset and is often asymptomatic. Managing patients with juvenile idiopathic arthritis-associated uveitis remains challenging as the disease may prove to be refractory to traditional treatment regimens. Stepwise immunomodulatory therapy is indicated, with new biologic drugs being used last in cases of refractory uveitis. Small scale studies and practice have provided the evidence to undertake randomized control trials to evaluate the efficacy, safety, and cost-effectiveness of anti-tumor necrosis factor-α therapies, such as infliximab and adalimumab. These have demonstrated promising results, with further data awaited from ongoing trials for adalimumab (as SYCAMORE and ADJUVITE trials). Lower grade evidence is supporting the use of newer biologics such as rituximab, daclizumab, tocilizumab, and abatacept in those cases refractory to anti-tumor necrosis factor-α therapy.

  12. THERAPY OF FIBRINOUS PLASTIC ANTERIOR UVEITIS

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    A. L. Onishchenko

    2015-01-01

    Full Text Available Aim. To analyze the efficacy of modified pupillary massage technique using cycloplegic agent Appamide Plus in the treatment of anterior uveitis. Patients and methods. 45 patients (25 men and 20 women aged 21‑69 with endogenous uveitis (51 eyes were enrolled in the study. Etiology of uveitis was identified in 57.7 % of cases: herpes simplex virus (22.2 %; systemic disorders — rheumatoid arthritis, Reiter syndrome, Bechterew’s disease, psoriasis (17.7 %; local infection — purulent periodontitis or sinusitis (11 %. Patients were divided into two groups. Group I received basic therapy in combination with traditional pupillary massage. Group II received basic therapy in combination with modified pupillary massage using Appamide Plus (muscarinic receptor antagonist and alpha adrenergic agonist and plasma exchange with cell mass ozonation. Results. Inflammation of the uveal tract was prevented in all patients. In group I (traditional pupil massage, posterior synechiae persisted in 26 % of cases. In group II (pupil massage using Appamide Plus, anterior chamber humor was transparent, posterior synechiae were broken, normal pupillary response was re-established. Additionally, inflammatory exudate in the anterior chamber and endothelial precipitates resolved by 3.3 days earlier than in group I (р < 0.05. Visual outcomes were also better in Appamide Plus group. T cell-mediated immunity study revealed initial CD3+ cell and T cell subpopulation deficiency. Relative and absolute references of T cells and their subpopulations tended to decrease even when uveitis signs reduced. Conclusions. T cell-mediated immunity depression is probably due to pharmacotherapy. Appamide Plus eye drops are highly effective for therapeutic mydriasis and pupillary massage in the course of anterior uveitis treatment to prevent synechiae formation in enlarged or small pupil.

  13. Avaliação das perdas causadas por vírus na produção da batata I: Vírus do enrolamento da fôlha Evaluation of yield losses induced by potato leaf roll

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    F. P. Cupertino

    1970-01-01

    Full Text Available A comparação entre as produções de 50 pares de plantas sadias e afetadas, de nove variedades de batata, mostra que a redução na produção causada pela infecção secundária do vírus do enrolamento da fôlha foi, em média, de 60,8% no pêso total dos tubérculos produzidos e de 75,5% no pêso dos tubérculos do tipo graúdo ("especial" mais "primeira". As perdas na produção total variaram de 44,6% (variedade Patrones a 73,4% (variedade Aquila, e na de tubérculos graúdos, de 49,8% (Delta A a 86,0% (Gunda.A comparison of 50 pairs of field healthy and leaf roll infected potato plants of nine varieties indicated that the total yield reduction was on the average 60.7 per cent. Yield reduction of the two largest and most marketable potato sizes ("especial" and "primeira" reached 75.6 per cent. Aquila and Gunda had the highest yield losses (73.4 and 72.0 per cent; Delta A and Patrones had the lowest (47.6 and 44.6 per cent. Reduction in the yield of the larger tuber sizes was generally greater than total losses.

  14. Sex and Reproduction in the Transmission of Infectious Uveitis

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    Janet L. Davis

    2014-01-01

    Full Text Available Current data permit only speculations regarding sex differences in the prevalence of infectious uveitis between women and men because uveitis case surveys do not uniformly report gender data. Differences in prevalence that are reported in the literature could relate to simple differences in the number of women and men at risk for infection or to biological differences between men and women. Compared to other types of uveitis, infectious uveitis may be directly related to occupational exposures or sexual behaviors, which differ between women and men, and may mask actual biological differences in susceptibility to ocular manifestations of the infection and its prognosis. In infectious uveitis for which there is no element of sexual transmission and data is available, prevalence of ocular disease is roughly equal between women and men. Women also have a unique relationship with infectious uveitis in their role as mothers. Vertical transmission of infections such as herpes simplex, toxoplasmosis, and cytomegalovirus can produce severe chorioretinitis in neonates.

  15. Mycobacterial heat shock protein 65 and experimental autoimmune uveitis

    Institute of Scientific and Technical Information of China (English)

    杨俊杰

    2010-01-01

    @@ Uveitis, common cause of human visual disability and blindness, is an inflammatory eye disease of unknown etiology. Human autoimmune uveiti, which characterizes inflammation of different tissues of the eyes, is diverse and complex. Approximately 50% of patients with uveitis were found to occur in families in which clustering of other underlying systemic autoimmune diseases has been observed (multiplex families) such as diabetes, sarcoidosis, rheumatoid arthritis (RA), Behcet disease, multiple sclerosis (MS), and others [1-3]. Animal models of experimental autoimmune uveitis (EAU), which represent different forms of clinical uveitis, have been widely used for studying the immunopathological mechanisms of uveitis to develop preventive or therapeutic strategies because of the difficulties in obtaining tissues from a patient's inflamed eye for experiments [4].

  16. Presenting A Case with Tubulointerstitial Nephritis and Uveitis (TINU- Syndrome

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    E Fotouhi Ardakani

    2008-10-01

    Full Text Available Concurrence of interstitial nephritis and uveitis named tubulointestitioal nephritis and uveitis syndrome (TINU are unusual and uncommon presentations of interstitial nephritis. This syndrome is considered after ruling out other differential diagnoses. A-38-year old man presented with acute renal failure and uveitis. The histologic findings of renal biopsy showed acute tubulointestitioal nephritis. The patient had no clinical and paraclinical manifestations of other etiologies of interstitial nephritis and uveitis such as Wegener's granulomatosis , Sjogren's syndrome or sarcoidosis. The diagnosis of TINU-Syndrome was therefore considered. The patient was treated by oral and ophthalmic prednisolone and had a good response to treatment.

  17. Ipsilateral Uveitis and Optic Neuritis in Multiple Sclerosis

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    Eric Thouvenot

    2012-01-01

    Full Text Available Background. Uveitis is 20 times more frequent in multiple sclerosis (MS patients than in the general population. Methods. A retrospective study of local multiple sclerosis (n=700 and uveitis cohorts (n=450 described the ophthalmological and neurological characteristics of patients with multiple sclerosis and uveitis. Results. Uveitis and multiple sclerosis were associated in seven patients. The time intervals between diagnoses of MS and uveitis ranged from 6 months to 15 years. Analysis of the patients’ characteristics revealed that multiple sclerosis was associated with an older age of onset than usually expected, that is, 39 years. Uveitis was bilateral in three cases and mainly posterior (5/10. Five patients presented with acute optic neuritis (two in one eye and three in both eyes. All eyes presenting with acute optic neuritis were also affected by uveitis (P=0.02, though not simultaneously. Conclusion. The ipsilateral association between optic neuritis and uveitis in this series of patients with multiple sclerosis may suggest a reciprocal potentiation between optic neuritis and uveitis in multiple sclerosis.

  18. Causes of uveitis in children without juvenile idiopathic arthritis

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    Engelhard SB

    2015-06-01

    Full Text Available Stephanie B Engelhard, Asima Bajwa, Ashvini K ReddyDepartment of Ophthalmology, University of Virginia, Charlottesville, VA, USABackground: The purpose of this study was to report the demographics, disease characteristics, treatments, and visual outcomes of pediatric uveitis patients without juvenile idiopathic arthritis managed in a tertiary medical center.Methods: A retrospective, observational study was performed in pediatric uveitis patients without juvenile idiopathic arthritis and aged 0–18 years, who were seen at the University of Virginia from 1984 to 2014.Results: Thirty-nine pediatric uveitis patients (57 eyes were identified. The patient population was 51.28% female, 51.28% Caucasian, and 33.33% African American. The mean age at diagnosis was 11.9 years. The mean duration of follow-up was 3.11 years. The mean number of visits to the clinic was 10.41. Of 57 eyes, 31 (54.39% had anterior uveitis, 12 (21.05% had intermediate uveitis, nine (15.79% had posterior uveitis, and five (8.77% had panuveitis. The leading diagnoses were traumatic uveitis (25.64%, undifferentiated anterior uveitis (17.95%, undifferentiated intermediate uveitis (15.38%, HLA-B27-associated anterior uveitis (7.69%, and herpetic anterior uveitis (7.69%. Systemic associations included sarcoidosis, ulcerative colitis, and psoriatic arthritis (n=3. The most common treatment modalities included local steroids (66.67%, systemic steroids (23.08%, and antimetabolites (20.51%. Ocular hypertension was found in five (12.82% patients. Ocular surgery was performed in six (15.38% patients. Mean best-corrected visual acuity (BCVA at baseline across all anatomical locations was 0.458 logMAR, and was 0.411 logMAR at final follow-up. Mean BCVA improved during follow-up in all but the anterior uveitis group. The mean baseline intraocular pressure was 14.27 mmHg, and was 14.22 mmHg at final follow-up.Conclusion: Uveitis in childhood is a vision-threatening group of inflammatory

  19. Histochemical analysis of experimental granulomatous uveitis.

    Science.gov (United States)

    Kristeva, M; Biswas, J; Pararajasegaram, G; Sevanian, A; Rao, N A

    1991-01-01

    We have previously demonstrated the effects of various inhibitors of arachidonic acid metabolism on experimental lens-induced granulomatous uveitis. In the present study, we investigated the effect of these same inhibitors on the expression of lysosomal enzymes at different stages of choroidal inflammation in experimental lens-induced granulomatous uveitis and compared this to the inflammation observed at each stage examined. Lysosomal enzymes such as acid phosphatase, beta-glucuronidase and succinate dehydrogenase are known to be liberated during the maturation of mononuclear phagocytes to epithelioid cell granulomas. Although animals treated with nordihydroguaiaretic acid showed less severe inflammation than did indomethacin-treated or control animals, none of these agents appeared to affect the expression of acid phosphatase and beta-glucuronidase, as determined histochemically. Succinate dehydrogenase could not be detected in any of the eyes examined, even though sections of liver and kidney from these same animals were positive for this enzyme.

  20. Pseudomonas aeruginosa endophthalmitis masquerading as chronic uveitis

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    Kalpana Badami Nagaraj

    2013-01-01

    Full Text Available A 65-year-old male presented with decreased vision in the left eye of 15-day duration after having undergone an uneventful cataract surgery 10 months back. He had been previously treated with systemic steroids for recurrent uveitis postoperatively on three occasions in the same eye. B-scan ultrasonography showed multiple clumplike echoes suggestive of vitreous inflammation. Aqueous tap revealed Pseudomonas aeruginosa sensitive to ciprofloxacin. The patient was treated with intravitreal ciprofloxacin and vancomycin along with systemic ciprofloxacin with good clinical response. Even a virulent organism such as P.aeruginosa can present as a chronic uveitis, which, if missed, can lead to a delay in accurate diagnosis and appropriate management.

  1. Ocular immunology in equine recurrent uveitis.

    Science.gov (United States)

    Deeg, Cornelia A

    2008-09-01

    Equine recurrent uveitis (ERU) is a disease with high prevalence and relevance for the equine population, since it results in blindness. Over the last decade, important advancements have been made in our understanding of the underlying immune responses in this disease. ERU is mediated by an autoaggressive Th1 response directed against several retinal proteins. Interphotoreceptor-retinoid binding protein (IRBP) and cellular retinaldehyde-binding protein (CRALBP) are capable to induce ERU-like disease in experimental horses, with the unique possibility to activate relapses in a well-defined manner. Further, proteomic evidence now suggests that retinal Mueller glial cells (RMG) may play a fatal role in uveitic disease progression by directly triggering inflammation processes through the expression and secretion of interferon-gamma. Ongoing relapses in blind eyes can be associated with stable expression of the major autoantigens in ERU retinas. This review briefly summarizes the most significant developments in uveitis immune response research.

  2. Fuchs uveitis,heterochromia,and uveitis as a coincidental finding in a case

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    Gholamhossein Yaghoobi

    2013-08-01

    Full Text Available The classical clinical triad of retinitis pigmentosa is arteriolar attenuation , retinal bone-spicule pigmentation and waxy disc pallor.   A 33 year old female patient is introduced here. She had unilateral posterior subcapsular cataract, heterochromic iris, and uveitis.The patient also suffered night blindness , had a family history of low vision ,and reduced visual acuity in her right eye. After the best correction, visual acuity was: OD=20.200 and OS=20.20 (with-1.5 spher-0.50cyl x 170. Anterior segment examination revealed trace cell with diffused moderate keratic precipitate and heterochoromia with posterior subcapsular cataract .But the examination revealed a normal condition in the left eye. Both eyes had characteristic retinal changes of retinitis pigmentosa. Retinitis pigmentosa can be associated with Fuch’s- like uveitis sporadicallybut Fuch’s heterochromic uveitis of affected pedigree was not found.

  3. Birdshot uveitis: current and emerging treatment options

    OpenAIRE

    Menezo V; Taylor SRJ

    2013-01-01

    Victor Menezo,1,2 Simon RJ Taylor3,4 1Institut Catala de Retina, Barcelona, Spain; 2Department of Ophthalmology, Provincial Hospital Consortium Castellon, Castello, Spain; 3Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK; 4Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK Abstract: Birdshot chorioretinopathy is a relatively uncommon subtype of idiopathic posterior uveitis with distinct clinical characteristics and a strong genetic association wit...

  4. [Efficiency evaluation of non-infectious uveitis].

    Science.gov (United States)

    Krásná, J; Mezerová, V; Krásný, J

    2013-08-01

    Authors compared clinical and economic effeciency of treatment of the classical corticosteroids therapy and modern immunosuppressive treatment or their combination. Retrospective evaluation carried out in 2012, covering 2006-2011, monitored sample of 27 patients, 16 women and 11 men, 45 eyes with disabilities. The average age in the last year of follow-up monitoring was 30.2, ranging from 14 to 76 years. The mean duration of disease for the whole sample is 16.5 years with a range from 6 to 36 years. Three basic diagnoses were included in investigated group: chronic iridocyclitis in 59 % of eyes, intermediate uveitis in 30 % of eyes and sympathetic ophthalmia in 11 % of eyes. The optimal treatment not be determined, however, combined corticosteroid sparing therapy was the most beneficial to maintain in terms of visual acuity with minimal side effects and cost effectiveness. Successful outcomes of treatment were observed for intermediate uveitis, because the visual acuity improved in nine letetters of ETDRS chart in the study. Satisfactory treatment was proved in chronic iridocyclitis and sympathetic ophthalmia in general, because visual acuity improved in a few letters of ETDRS chart, in the same line as in the beginning of the six-year follow-up. Rounded average annual prize for treatment including pharmacotherapy, outpatient and inpatient care and laboratory follow-up was in chronic iridocyclitis € 990, in intermediate uveitis € 310 and sympathetic ophthalmia € 1550. Pharmacotherapy exceeded the financial appraisal of specialized medical and inpatient care in total cost. Key words: uveitis, corticosteorids, immunosuppression, costeffectivness.

  5. Equine recurrent uveitis: new methods of management.

    Science.gov (United States)

    Gilger, Brian C; Michau, Tammy Miller

    2004-08-01

    Equine recurrent uveitis (ERU) is one of the most common causes of blindness in horses. Until recently, treatment of this condition consisted only of symptomatic therapy, typically with steroidal and nonsteroidal medications. A better understanding of the disease process(es) has permitted new medical and surgical therapies that have recently been described. This article highlights clinical features of ERU, the causes of ERU, and new management and treatment options for horses with ERU.

  6. Twenty-five gauge vitrectomy in uveitis

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    Roger Roberto Wada Kamei

    2012-04-01

    Full Text Available PURPOSE: To evaluate anatomical and functional results of 25-gauge transconjunctival sutureless pars plana vitrectomy in patients with uveitis. METHODS: Vitrectomy was performed on 20 eyes with residual vitritis secondary to infectious and noninfectious uveitis. Patients were evaluated 1 week before surgery and after surgery at day 1, week 1, week 4 and week 12. Visual acuity (VA, intraocular pressure, anterior chamber cells and flare and vitreous haze were measured. RESULTS: Mean VA improved from 2.06 ± 0.94 logMAR before surgery to 0.58 ± 0.46 logMAR at week 12 (p<0.05. No case required conversion to standard 20-gauge instrumentation or suture placement, no intraoperative complications were noted. Transient postoperative hypotony was seen in three eyes. One patient with toxoplasmic retinochoroiditis had a relapse during follow-up. CONCLUSION: 25-gauge vitrectomy has proven its efficacy on cleansing vitreous opacities and improving visual acuity on patients with residual vitritis secondary to uveitis with minimal postoperative inflammation and complications.

  7. Incidência e etiologia de uveítes em Curitiba Incidence and etiology of uveitis in Curitiba

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    Marcelo Luis Gehlen

    1999-10-01

    Full Text Available Objetivo: Determinar a incidência e a etiologia dos casos de uveítes em Curitiba-PR. Métodos: Foram estudados 68 casos de uveítes em Curitiba, PR, atendidos no ambulatório de oftalmologia no período de janeiro a abril de 1998 procurando estabelecer o diagnóstico a partir de ampla investigação clínica e laboratorial. Resultados: Em nosso estudo, constatamos que a uveíte posterior foi a mais encontrada (49%, seguindo-se a panuveíte (29% e, com menor freqüência, a uveíte anterior (22%. A etiologia mais freqüente para as uveítes posteriores foi a toxoplasmose, responsável por 88% dos casos. Entre as panuveítes, novamente a toxoplasmose prevaleceu, com 85% e, dentro das uveítes anteriores, a principal causa foi a espondilite anquilosante com 20%. Conclusão: Em Curitiba, há um predomínio de uveítes posteriores e panuveítes, sendo a causa mais comum a toxoplasmose. No entanto, enfatiza-se que existem outras causas importantes de uveítes que devem ser lembradas pelo oftalmologista na investigação clínica.Purpose: To study the incidence and etiology of uveitis in Curitiba, PR, Brazil. Methods: Sixty-eight cases of uveitis were studied in Curitiba, PR between January and April, 1998. Clinical and laboratorial research was performed in order to establish the diagnosis. Results: In this study, we found that posterior uveitis was the most frequent (49%, followed by panuveitis (29%, and, less frequently, anterior uveitis (22%. The major etiology of posterior uveitis was toxoplasmosis, responsible for 88% of the cases; among panuveitis, toxoplasmosis also predomi-nated, representing 85% and, the main cause of anterior uveitis was ankylosing spondilytis with 20%. Conclusions: In Curitiba, posterior uveitis and panuveitis predominate, and the most frequent etiology is toxoplas-mosis. However, its important to emphasize that there are other important causes of uveitis which should be remem-bered by the ophthalmologist during the

  8. Otitis externa por Demodex cati

    OpenAIRE

    L. Real; Ortuñez, A.; Verde Arribas, Mª T.; Navarro, L.; Vilela, C

    2010-01-01

    La demodicosis por Demodex cati es una enfermedad parasitaria poco común que se presenta bajo tres formas clínicas: generalizada, localizada y otitis externa ceruminosa u otodemodicosis. El objetivo de esta comunicación es presentar dos casos clínicos de otitis ceruminosa causada por D.cati sin la presencia de otros síntomas cutáneos.

  9. PROGRESSION AND OUTCOMES OF UVEITIS IN PATIENTS WITH ANKYLOSING SPONDILITIS

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    A. A. Godzenko

    2014-01-01

    Full Text Available Uveitis is a common extraskeletal manifestation of ankylosing spondylitis (AS occurring in 20–40% of patients. Mostauthors underline a favorable prognosis for AS-associated uveitis.Objective: to study features of clinical picture and progression of AS-associated uveitis and to estimate the occurrence of its complications.Subjects and methods. Across-sectional study of 140 patients (98 males and 42 females with AS, who had at least one uveitis attack over the period of disease and was followed up at V.A. Nasonova Research Institute of Rheumatology during 2008–2012. In addition to standard rheumatologic examination all patients were examined by ophthalmologist. Biomicroscopy, ophthalmoscopy, tonometry, computer-assisted perimetry, ultrasonography (B-scanning of eyes and, if needed, fluorescein angiography and electrophysiological examination of retina were performed. Localization of uveitis, presence of complications affecting vision, total number of uveitis attacks by the moment of examination, mean number of uveitis attacks per year, correlation between the frequency of attacks and complications, presence of other extraskeletal manifestations and peripheral arthritis were assessed. The total number of uveitis attacks was defined from patients' interviews and respective medical documentation. Mean number of uveitis attacks was calculated as ratio of total number of uveitis attacks to the duration of disease for each patient. In the case of more than two attacks per year uveitis progression was consideredrefractory.Results.Mean duration of the disease was 17.7±11.03 years. In 19 patients (14% AS manifested before and in 121 (86% – after the age of 16 years. HLA-B27 was revealed in 135 (96% patients, peripheral arthritis – in 43 (30%, whereas other extraskeletal manifestations – in 46 (32%. Early onset of uveitis in first 10 years of the disease was recorded in 81 (58% patients, after10 years – in 21 (15%. Uveitis was the

  10. Uveitis as first manifestation of probably Crohn's disease

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    Ieda Maria Alexandre Barreira

    2012-12-01

    Full Text Available Extraintestinal manifestations of Crohn's disease are common. Although ocular complications of Crohn's disease are infrequent, most ocular manifestations include iritis, uveitis, episcleritis, scleritis and conjuntivitis. We report a patient who developed uveitis two years before diagnose of Crohn's disease.

  11. Impact of Juvenile Idiopathic Arthritis Associated Uveitis in Early Adulthood

    NARCIS (Netherlands)

    Haasnoot, Anne-Mieke J. W.; Vernie, Lenneke A.; Rothova, Aniki; van der Doe, Patricia; Los, Leonoor I.; Schalij-Delfos, Nicoline E.; de Boer, Joke H.

    2016-01-01

    Background Typically juvenile idiopathic arthritis (JIA)-associated uveitis (further referred as 'JIA-uveitis') has its onset in childhood, but some patients suffer its, sometimes visual threatening, complications or ongoing disease activity in adulthood. The objective of this study was to analyze u

  12. Impact of juvenile idiopathic arthritis associated uveitis in early adulthood

    NARCIS (Netherlands)

    Haasnoot, A.-M.J.W. (Anne-Mieke J. W.); Vernie, L.A. (Lenneke A.); A. Rothova (Aniki); Doe, P.V.D. (Patricia V. D.); L.I. Los (Leonoor I.); N.E. Schalij-Delfos (Nicoline); J.H. de Boer (Joke)

    2016-01-01

    textabstractBackground: Typically juvenile idiopathic arthritis (JIA)-associated uveitis (further referred as 'JIA-uveitis') has its onset in childhood, but some patients suffer its, sometimes visual threatening, complications or ongoing disease activity in adulthood. The objective of this study was

  13. Infectious uveitis. New developments in etiology and pathogenesis

    NARCIS (Netherlands)

    de Visser, L.

    2009-01-01

    Uveitis is an inflammation of the inner-eye and is initiated by various infectious and noninfectious causes. In a large portion of patients the etiology is unknown and might be associated with until now undiagnosed infections.The identification of infectious uveitis is of crucial importance since it

  14. Impact of Juvenile Idiopathic Arthritis Associated Uveitis in Early Adulthood

    NARCIS (Netherlands)

    Haasnoot, AJW; Vernie, Lenneke A; Rothova, Aniki; V D Doe, Patricia; Los, Leonoor I; Schalij-Delfos, Nicoline E; de Boer, Joke H

    2016-01-01

    BACKGROUND: Typically juvenile idiopathic arthritis (JIA)-associated uveitis (further referred as 'JIA-uveitis') has its onset in childhood, but some patients suffer its, sometimes visual threatening, complications or ongoing disease activity in adulthood. The objective of this study was to analyze

  15. SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis

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    Chang He

    2016-01-01

    Full Text Available Uveitis is a potentially sight-threatening disease characterized by repeated cycles of remission and recurrent inflammation. The JAK/STAT pathway regulates the differentiation of pathogenic Th1 and Th17 cells that mediate uveitis. A SOCS1 mimetic peptide (SOCS1-KIR that inhibits JAK2/STAT1 pathways has recently been shown to suppress experimental autoimmune uveitis (EAU. However, it is not clear whether SOCS1-KIR ameliorated uveitis by targeting JAK/STAT pathways of pathogenic lymphocytes or via inhibition of macrophages and antigen-presenting cells that also enter the retina during EAU. To further investigate mechanisms that mediate SOCS1-KIR effects and evaluate the efficacy of SOCS1-KIR as an investigational drug for chronic uveitis, we induced EAU in rats by adoptive transfer of uveitogenic T-cells and monitored disease progression and severity by slit-lamp microscopy, histology, and optical coherence tomography. Topical administration of SOCS1-KIR ameliorated acute and chronic posterior uveitis by inhibiting Th17 cells and the recruitment of inflammatory cells into retina while promoting expansion of IL-10-producing Tregs. We further show that SOCS1-KIR conferred protection of resident retinal cells that play critical role in vision from cytotoxic effects of inflammatory cytokines by downregulating proapoptotic genes. Thus, SOCS1-KIR suppresses uveitis and confers neuroprotective effects and might be exploited as a noninvasive treatment for chronic uveitis.

  16. Uveitis in juvenile chronic arthritis: incidence, clinical features and prognosis.

    Science.gov (United States)

    Kanski, J J

    1988-01-01

    Three hundred and fifteen patients with anterior uveitis and juvenile chronic arthritis were reviewed in order to determine the incidence, visual prognosis, and the clinical characteristics of the intraocular inflammation. The overall incidence of uveitis was 20%. Approximately 25% of patients had relatively mild and/or transient involvement and an excellent visual prognosis. In 50% the uveitis was more severe but could be controlled with topical medication. In the remaining 25% the visual prognosis was poor due to the intractable nature of the uveitis and the subsequent development of vision-threatening complications. The majority of patients (74%) were under the age of 8 years when the uveitis was first diagnosed. Clinically, the intraocular inflammation was most frequently an asymptomatic, chronic, non-granulomatous, iridocyclitis which was bilateral in 71% of cases. Other ocular lesions, which were rare, included keratoconjunctivitis sicca and corneal melting.

  17. Uveitis: advances in understanding of pathogenesis and treatment.

    Science.gov (United States)

    Read, Russell W

    2006-08-01

    Uveitis is a leading cause of blindness affecting individuals of all ages, genders, and races. Uveitis may be due to autoimmune, infectious, toxic, malignant, or traumatic processes. Some evidence supports an association between conditions previously presumed to be autoimmune and viral infectious agents. For autoimmune uveitis, therapy is nonspecific, typically beginning with corticosteroids. For nonresponsive disease or for corticosteroid sparing, recent reports on mycophenolate mofetil, infliximab, and interferon therapy show success for various forms of uveitis. Treatment of the complications of uveitis, especially cystoid macular edema, is difficult. Vitamin E appears to offer little benefit, whereas octreotide may be effective. Recent collaborative efforts at standardization in the field should enhance studies on these conditions.

  18. Is uveitis associated with topiramate use? A cumulative review

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    Goldberg JL

    2016-08-01

    Full Text Available Jeffrey L Goldberg,1 Amy G Lau,2 Bo Fan,2 Lisa Ford,3 Howard E Greenberg3 1Byers Eye Institute, Stanford University, Palo Alto, CA, 2Janssen Research & Development, LLC, Horsham, PA, 3Janssen Research & Development, LLC, Titusville, NJ, USA Abstract: Occasional reports of uveitis following topiramate use necessitated an investigation of relevant cases from safety databases and published biomedical literature. Data mining of the Food and Drug Administration Adverse Event Reporting System and cumulative review of cases from the global safety database (sponsor database and published literature were conducted to assess association between topiramate use and uveitis. The Food and Drug Administration Adverse Event Reporting System search identified disproportional reporting of uveitis (n=23 and related terms (choroidal detachment, n=25; iridocyclitis, n=17. The postmarketing reporting frequency of uveitis and related events from the global safety database and based on an estimated topiramate exposure of 11,185,740 person-years from launch to April 2015 was 0.38 per 100,000 person-years and assigned as very rare. A total of 14 potential uveitis cases were identified from the cumulative review. Seven of these 14 cases were complicated by inadequate documentation, appearance of uveitic signs following drug withdrawal, or concurrent use of other sulfonamides. In acute angle-closure glaucoma and uveal effusions cases, insufficient evidence for underlying inflammation suggested that uveitis was not a component. Only seven of 14 cases were well documented, potentially topiramate-associated uveitis cases. Uveitis may occur in the setting of topiramate use only in very rare instances. Current evidence did not reveal a dose- or duration-dependent relationship between uveitis and topiramate use. Keywords: topiramate, uveitis, acute angle-closure glaucoma, drug safety, Food and Drug Administration Adverse Event Reporting System, postmarketing 

  19. Traumatic uveitis in the mid-Atlantic United States

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    Engelhard SB

    2015-10-01

    Full Text Available Stephanie B Engelhard,1 James Patrie,2 John Prenshaw,1 Asima Bajwa,1 Rose Monahan,1 Ashvini K Reddy1 1Department of Ophthalmology, 2Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Purpose: The purpose of this study was to conduct an in-depth analysis of traumatic uveitis in patients managed in a mid-Atlantic tertiary care center with the goal of better characterizing the clinical features and outcomes of this large and important subset of uveitis patients.Methods: This was a retrospective, observational study comparing traumatic uveitis patients with nontraumatic uveitis patients seen at the University of Virginia, Charlottesville, VA, USA, from 1984 to 2014.Results: Fifty-four traumatic uveitis patients (55 eyes were identified. The patient population was 70.4% male, 57.4% Caucasian, and 37.0% African American. Mean age at diagnosis was 31.2 years; mean duration of follow-up was 5.4 years; and mean number of visits to the clinic was 4. The most common treatment modality was local steroids (77.8%. Glaucoma was medically managed in eight patients (14.8%. Cataract surgery was performed in five patients (9.3%. Mean best-corrected visual acuity at baseline for traumatic uveitis patients was 0.33 logMAR (SD 0.42 at the initial visit and 0.16 logMAR (SD 0.33 at the final visit. Mean baseline intraocular pressure (IOP in the traumatic uveitis group was 15.5 mmHg (SD 7.4 at the initial visit and 14.6 mmHg (SD 4.0 at the final visit. Patients in the traumatic uveitis cohort tended to have better visual outcomes than those in the nontraumatic uveitis cohort.Conclusion: In our series, traumatic uveitis patients tended to be young and male and present with unilateral disease, all findings consistent with other reports. Despite relatively good visual outcomes, the traumatic uveitis patients still experienced a high burden of disease, measured both in the number of clinic visits and duration of follow-up. Due to the

  20. Patterns of Uveitis in the Middle East and Europe

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    Ebrahim M Nashtaei

    2011-01-01

    Full Text Available Purpose: To compare the patterns of uveitis, emphasizing similarities and discrepancies, in the Middle East and Europe. Methods: Six articles reporting uveitis patterns from the Middle East including a total of 2,693 cases, and seven articles with a sum of 4,379 cases from Europe were analyzed and patterns in each region were defined and compared. Results: In both regions, uveitis was most commonly seen in the fourth decade of life with anterior uveitis being the most common anatomical form. Idiopathic cases accounted for the majority of anterior and intermediate uveitis; toxoplasmosis was the most frequent entity in posterior uveitis while Behcet′s disease and idiopathic forms were the next most common causes in the Middle East and in Europe, respectively. Conclusion: Since patterns of uveitis differ in various geographic regions, discovering these patterns would be helpful for the diagnosis and treatment of this broad category of conditions. This necessitates applying a universal diagnostic classification system to enable accurate comparisons.

  1. Equine recurrent uveitis: the viewpoint from the USA.

    Science.gov (United States)

    Gilger, B C

    2010-03-01

    Equine recurrent uveitis (ERU) is a common disease in horses in the USA. There have been many advances in the treatment of ERU; however, frequent misdiagnosis of ERU occurs in cases of primary corneal or uveal disease. It is critical to remember that primary uveitis (i.e. one bout of inflammation) is a different disease to ERU, which is an immune mediated recurrent uveitis. Standard symptomatic anti-inflammatory therapy is effective to control most cases of ERU; however, some horses require advanced therapy, such as placement of drug delivery devices or removal of the vitreous, when they fail to respond to the standard therapy.

  2. Protocolo en el tratamiento de lesiones causadas por ondas expansivas: impacto sobre el diagnóstico tardío y una mejor oportunidad de manejo en un hospital académico nivel III – IV de atención

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    Juan Sanjuán

    2016-12-01

    Full Text Available Introducción: Las lesiones producidas por ondas expansivas comprometen diferentes áreas anatómicas por su mecanismo de lesión y se traducen en traumatismos severos. En Colombia, las principales causas de estas lesiones las constituyen situaciones de guerra y ataques terroristas puesto que el país se ha visto inmerso en la violencia durante varios años. Material y Métodos: Debido a la severidad y el compromiso de áreas resultantes de ese tipo de eventos, se diseñó e implemento un protocolo de atención que se propuso realizar lo siguiente: 1 Aplicar la evaluación primaria y secundaria del paciente, según los lineamientos del Soporte Vital Avanzado en Trauma del Colegio Americano de Cirujanos. 2 Hacer la evaluación sistemática por áreas anatómicas por parte del departamento quirúrgico, orientándola hacia el examen de las lesiones descritas con mayor frecuencia. 3 Llevar a cabo posteriormente una valoración de las lesiones específicas de acuerdo con las especialidades relacionadas. Para identificar las lesiones más frecuentes, se realizó un análisis retrospectivo de los casos registrados en el Hospital Universitario de Neiva, centro de referencia para el suroccidente de Colombia. Resultados: Durante ese periodo, se atendieron 35 pacientes cuyas áreas anatómicas comprometidas más frecuentes fueron las extremidades inferiores (con un registro del 60% de los casos, el abdomen (54,3% y el tórax (42,9%. La mortalidad general del grupo fue de 9,1%. Después de la implementación, se demostró una mejoría en la oportunidad de evaluación por cirugía general y se identificaron 6 pacientes con diagnósticos tardíos, previos a la implementación del protocolo. Conclusión: Este estudio determinó que la implementación de una revisión secuencial y un protocolo sistemático permiten mejorar la tasa de diagnósticos tardíos optimizando la evaluación diagnostica y el abordaje terapéutico.

  3. [The surgical therapy of equine recurrent uveitis].

    Science.gov (United States)

    Werry, H; Gerhards, H

    1992-04-01

    Equine recurrent uveitis (ERU) is the most frequently encountered cause of eye problems and blindness in horses. Classic treatment of ERU includes mydriatics, corticosteroids and nonsteroidal anti-inflammatory drugs. Despite vigorous topical and systemic treatment, however, in many cases, the prognosis for preserving vision remains poor. Experiences with surgical treatment of chronic endogenous uveitis in human patients have shown that vision-impairing axial opacities in the vitreous body can be removed by pars plana vitrectomy, and that a considerable decrease in the frequency and severity of uveitic relapses results. So far, 11 eyes of 10 horses were subjected to vitrectomy. All horses had suffered from 3 or more uveitic attacks and had a hazy vitreous. In all cases, at discharge from the clinic, the vitreous chamber was less hazy compared to preoperative findings. At follow-up examinations, 8 eyes (8/10) had normal i.o. pressure, and 2 (2/10) had subnormal i.o. pressure and the vitreous chambers were clear or contained only small floaters. Uveitic attacks had not been observed in the operated eyes. Postoperative complications included fibrinous, or fibrinous-haemorrhagic exudate in the anterior chamber of all eyes, and in one eye, a minor haemorrhage in the vitreous chamber. Our preliminary results indicate that pars plana vitrectomy assuring proper case selection and accurate surgical technique, may contribute to improvement of vision and may delay the progression of uveitic complications in horses.

  4. Behçet′s uveitis

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    Tugal-Tutkun Ilknur

    2009-01-01

    Full Text Available Behcet′s disease is a multisystem inflammatory disorder that is most common in countries along the ancient "Silk Road". The eye is the most commonly involved vital organ in Behηet′s patients and the typical form of involvement is a relapsing remitting panuveitis and retinal vasculitis. Uveitis is the initial manifestation of the disease in 10-15% of the patients. Anterior uveitis is always nongranulomatous. Diffuse vitritis, retinal infiltrates, sheathing of predominantly retinal veins, and occlusive vasculitis are the typical signs of posterior segment inflammation. Spontaneous resolution of acute inflammatory signs is a diagnostic feature. Fundus fluorescein angiography is the gold standard in monitoring inflammatory activity. Laser flare photometry is a useful noninvasive tool since flare readings correlate with fluorescein angiographic leakage. The most common complications are cataract, maculopathy, and optic atrophy. Male patients have a more severe disease course and worse visual prognosis. Immunomodulatory therapy is indicated in all patients with posterior segment involvement. Corticosteroids combined with azathioprine and/or cyclosporine is used initially. Biologic agents, including interferon alfa and infliximab, are used in resistant cases. Visual prognosis has improved in recent years with an earlier and more aggressive use of immunomodulatory therapy and the use of biologic agents in resistant cases.

  5. Diagnosis of neonatal group B Streptococcus sepsis by nested-PCR of residual urine samples Diagnóstico de sepse neonatal causada pelo estreptococo do grupo B por meio de dupla amplificação de amostras residuais de urina

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    Bruno Nicolino Cezarino

    2008-03-01

    four patients. Moreover, PCR has enabled us to use residue volumes of urine samples collected by non invasive, non sterile methods, what is technically adequate as GBS is not part of the normal urine flora, thus avoiding invasive procedures such as suprapubic bladder punction or transurethral catheterization. At the same time, the use of urine instead of blood samples could help preventing newborns blood spoliation.O estreptococo do grupo B (GBS constitui a causa mais freqüente de sepse neonatal precoce. O teste de referência continua sendo o isolamento em cultura, apesar de apresentar problemas de sensibilidade. O objetivo do presente estudo foi validar uma técnica de dupla amplificação e determinar a possibilidade do uso de amostras residuais de urina colhidas por método não invasivo, não estéril, para a confirmação da sepse por GBS em recém-nascidos. As amostras foram amplificadas com primers do principal gene de superfície do GBS. A insuficiência de volume de material biológico para a realização de exames para suporte de vida, além de outros necessários à identificação do agente etiológico de infecções é muito freqüente em recém-nascidos. Mesmo assim, decidimos definir critérios bastante rigorosos para a inclusão de pacientes na casuística: os recém-nascidos deveriam apresentar sinais e sintomas compatíveis com infecção pelo GBS; deveriam ter tido ao menos uma amostra enviada para cultura, podendo ser sangue, urina ou líquor; disponibilidade de volumes residuais dessas amostras, ou de outras colhidas no dia da hospitalização, antes da introdução da antibioticoterapia, de forma a possibilitar a análise por PCR, e evolução favorável com a antibioticoterapia empírica. Em apenas um dos quatro recém-nascidos a infecção foi confirmada por cultura, enquanto nos outros três casos a infecção foi considerada presuntiva (pacientes preencheram os critérios de inclusão, mas o GBS não foi isolado. De um total de 12 amostras

  6. Clinical patterns and characteristics of uveitis in a secondary hospital in southern China

    Institute of Scientific and Technical Information of China (English)

    Yang; Zheng; Li-Xin; Zhang; Qian-Li; Meng; Min; Zhang; Ying; Cui; Qing-Yang; Liu; Zhong-Ling; Luo; Li-Ping; Du

    2015-01-01

    AIM: To investigate the characteristics of uveitis in a secondary hospital in southern China.METHODS: We reviewed all records of patients with uveitis at Hengli Hospital from January 2008 to December2011. Demographic data, past history, ophthalmic examinations and other laboratory tests were analyzed.RESULTS: One hundred and ninety-nine uveitis patients were enrolled in this study, including 134(67.3%) males and 65 females(32.7%) with an average age of 41.0 ±15.1y. The anatomical distribution included103(51.8%) cases of anterior uveitis, followed by panuveitis(65, 32.7%), posterior uveitis(29, 14.6%) and intermediate uveitis(2, 1.0%). Of the 98(49.2%) non-idiopathic cases, there were 10.1% Behcet’s disease,9.5% Vogt-Koyanagi-Harada(VKH) syndrome, 7.5%infectious uveitis, 7.5% traumatic uveitis and 3.5%postoperative uveitis.CONCLUSION: Idiopathic anterior and posterior uveitis,Behcet’s disease, VKH syndrome, infectious uveitis and traumatic uveitis are the most common uveitis entities in a secondary hospital in southern China. Additional measures should be taken to prevent infectious and traumatic uveitis.

  7. Immunohistochemical changes in kidney glomerular and tubular proteins caused by rattlesnake (Crotalus vegrandis venom Cambios inmunohistoquímicos en proteínas de túbulo y glomérulo renal causadas por el veneno de la serpiente de cascabel (Crotalus vegrandis

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    María E. Girón

    2003-10-01

    Full Text Available Renal damage is an important cause of death in patients who have survived the early effects of severe crotalid envenomation. Extracellular matrix of renal tissue is altered by Crotalus toxin activities. The aim of this study was to describe how cytoskeletal proteins and basal membrane components undergo substantial alterations under the action of Crotalus vegrandis crude venom and its hemorrhagic fraction (Uracoina-1 in mice. To detect the proteins in question, the immunoperoxidase method with monoclonal and polyclonal antibodies was used. Cell types within renal lesions were characterized by phenotypic identification, by means of immunohistologic analysis of marker proteins using different primary antibodies against mesangial cells, endothelial cells, cytoskeletal proteins (intermediate filament, extracellular matrix and basal membranes. Samples for morphological study by standard procedures (biotin-streptavidin-peroxidase technique using light microscopy were processed. Positive and negative controls for each antigen tested in the staining assay were included. After crude venom and hemorrhagic fraction inoculation of mice, the disappearance of cytoskeletal vimentin and desmin and collagen proteins in the kidney was observed. In extracellular matrix and basal membranes, collagen type IV from envenomed animals tends to disappear from 24 h to 120 h after venom injection.El daño renal es una causa importante de muerte en pacientes que sobreviven a los efectos iniciales de los severos envenenamientos crotálicos. El objetivo de este estudio ha sido el describir como las proteínas del citoesqueleto y los componentes de membrana basal muestran alteraciones importantes en su manifestación, bajo la acción del veneno crudo de Crotalus vegrandis y una fracción hemorrágica (Uracoina-1 del mismo veneno ya que, la matriz extracelular del tejido renal es alterada por la actividad de estas toxinas. Para detectar las proteínas en cuestión se utiliz

  8. Cytomegalovirus as a cause of anterior uveitis in immunocompetent patients

    NARCIS (Netherlands)

    van Boxtel, Lonneke A. A.; van der Lelij, Allegonda; van der Meer, Johannes; Los, Leonoor I.

    2007-01-01

    Purpose: To describe 7 cases of unilateral, chronic and/or recurrent anterior uveitis caused by cytomegalovirus (CMV) in immunocompetent patients; to identify specific ophthalmologic characteristics; and to evaluate the clinical effect of valganciclovir treatment. Design: Retrospective observational

  9. Anatomical and ultrastructural aspects of leaf galls in Ficus microcarpa L.f. (Moraceae induced by Gynaikothrips ficorum Marchal (Thysanoptera Aspectos anatômicos e ultra-estruturais de galhas foliares em Ficus microcarpa L.f. (Moraceae causadas por Gynaikothrips ficorum Marchal (Thysanoptera

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    Silvana Cristina P. M. de Souza

    2000-04-01

    Full Text Available Several species of Ficus present leaf galls and the goal of this research is to study the structural alterations involved in the formation of leaf galls caused by Gynaikothrips ficorum on F. microcarpa, an ornamental plant. The galls of young and mature leaves were separated into two developmental stages based on the presence of lesions on leaf lamina and the degree of leaf folding. Swellings of the lamina were observed in young and mature leaves during gall development which coincided with the areas of cellular hypertrophy and tissue hyperplasia. Swellings were detected in a greater amount and more precociously on young leaves when compared to mature ones. In young leaves, the cecidogenetic responses were quicker and led to further structural differences because younger cells are not completely differentiated. Cell hypertrophy and tissue hyperplasia were striking processes involved in the ontogenesis of the studied gall, similar to other galls induced by thrips. Nevertheless, in spite of the numerous sites of feeding and the wide area of attack, F microcarpa galls can be considered rudimentary, since no new tissue differentiation was observed.Galhas foliares são comuns em diversas espécies de Ficus. O objetivo deste trabalho é estudar as alterações estruturais envolvidas na formação das galhas foliares induzidas por Gynaikothripsficorum (Thysanoptera em Ficus microcarpa, uma planta ornamental. As galhas de folhas jovens e maduras foram separadas em dois estádios de desenvolvimento, com base na presença de lesões e no grau de dobramento da lâmina. Durante o desenvolvimento da galha formam-se intumescimentos na lâmina tanto nas folhas jovens quanto nas maduras, os quais coincidem com as áreas de hipertrofia celular e hiperplasia dos tecidos. Estes intumescimentos foram detectados em maior quantidade e mais precocemente em folhas jovens, que, por possuirem células menos diferenciadas, mostraram respostas cecidogenéticas mais r

  10. Ocular hypertension and hypotony as determinates of outcomes in uveitis

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    Aman R

    2015-12-01

    Full Text Available Rabia Aman,1 Stephanie B Engelhard,1 Asima Bajwa,1 James Patrie,2 Ashvini K Reddy1 1Department of Ophthalmology, 2Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Purpose: To assess ocular hypertension (OHT and hypotony as outcomes of uveitis in patients managed in a mid-Atlantic tertiary care center. Methods: Retrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014. Results: A total of 442 patients (582 eyes with uveitis were identified and included in the study. The patient population was 57.0% female. Overall, 61.9% were Caucasian and 26.6% were African American. Mean age was 46.8 years. Overall, 11.5% of the eyes had OHT at initial visit, and 7.9% had OHT at final visit (P=0.035. For each additional decade of life, the odds that an eye had OHT were elevated by a factor of 1.15 (95% confidence interval [CI]: [1.02, 1.30], P=0.027 at initial visit and by a factor of 1.15 (95% CI: [1.00, 1.32], P=0.055 at final visit. The odds that an anterior uveitis eye had OHT were greater by a factor of 2.50 (95% CI: [1.22, 5.14], P=0.013 than the odds for a nonanterior uveitis eye at initial visit and greater by a factor of 2.61 (95% CI: [1.24, 5.50], P=0.011 at final visit. For each additional 0.5 logarithm of the minimum angle of resolution increase in initial visual acuity, the odds that an affected eye had OHT were elevated by a factor of 1.18 (95% CI: [1.00, 1.39], P=0.047 at initial visit and 1.23 (95% CI: [0.99, 1.54], P=0.065 at final visit. Overall, 21 of 582 eyes (3.6% were hypotonous initially, while 24 of 582 eyes (4.1% were hypotonous at final follow-up (P=0.631. Conclusion: OHT was associated with increasing age, anterior uveitis, and poor presenting visual acuity. Ocular hypotony was more common in anterior uveitis than in nonanterior uveitis. Fluctuations in intraocular pressure are an important cause of visual impairment in patients with uveitis

  11. Fluorescein angiographic findings and clinical features in Fuchs' uveitis.

    Science.gov (United States)

    Bouchenaki, Nadia; Herbort, Carl P

    2010-10-01

    Fuchs' uveitis is very often diagnosed with substantial delay, which is at the origin of deleterious effects such as unnecessary treatment and its consequences. The aim of this study was to analyse the type and frequency of posterior inflammatory and fluorescein angiographic signs in Fuchs' uveitis in conjunction with other clinical signs. Patients seen at the Centre for Ophthalmic Specialised Care (COS) in Lausanne and the Memorial A. de Rothschild, Clinique Générale-Beaulieu in Geneva between 1995 and 2008 with the diagnosis of Fuchs' uveitis and who had undergone a fundus fluorescein angiography (FFA) were analysed. In addition to FFA signs, the data collected included age, gender, initial and final visual acuities, clinical findings at presentation, mean diagnostic delay and ocular complications. Between 1995 and 2008, 105 patients seen in our centres in Lausanne and Geneva were diagnosed with Fuchs' uveitis. Forty of them (38.1%) had undergone at least one FFA. One patient was excluded because of a concomittant diagnosis of multiple sclerosis. In 28 of 39 patients (71.2%) diagnosis was not reached at presentation with a mean diagnosis delay of 3.67 ± 4.86 years (range: 1 month-24 years). The original erroneous diagnosis was intermediate uveitis in 16 patients (57.1%), posterior uveitis in two patients (7.1%), panuveitis in four patients (14.3%) and anterior granulomatous uveitis in six patients (21.4%). Fluorescein angiography demonstrated the presence of disc hyperfluorescence in 43/44 eyes (97.7%), sectorial peripheral retinal vascular leaking in 6/44 eyes (13.6%) and cystoid macular oedema in 4/44 eyes (9.1%), all of which were seen in eyes having undergone cataract surgery. Fuchs' uveitis was bilateral in 5/39 patients (12.8%). The most frequent clinical signs were vitritis in 42/44 eyes (95.5%), stellate keratic precipitates in 41 eyes (93.2%), posterior subcapsular opacities or cataract in 19 eyes (43.2%), and heterochromia in 19 eyes (43.2%). Fuchs

  12. The histopathology of cutaneous leishmaniasis due to Leishmania (Leishmania mexicana in the Yucatan peninsula, Mexico Histopatologia de la leishmaniasis cutánea causada por Leishmania (Leishmania mexicana en la península de Yucatán, México

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    Fernando J. Andrade-Narvaez

    2005-08-01

    Full Text Available Localized Cutaneous Leishmaniasis (LCL known as "chiclero's ulcer" in southeast Mexico, was described by SEIDELIN in 1912. Since then the sylvatic region of the Yucatan peninsula has been documented as an endemic focus of LCL. This study of 73 biopsies from parasitological confirmed lesions of LCL cases of Leishmania (Leishmania mexicana infection was undertaken: 1 to examine host response at tissue level; and 2 to relate manifestations of this response to some characteristics of clinical presentation. Based on Magalhães' classification we found that the most common pattern in our LCL cases caused by L. (L. mexicana was predominantly characterized by the presence of unorganized granuloma without necrosis, (43.8%. Another important finding to be highlighted is the fact that in 50/73 (68.5% parasite identification was positive. There was direct relation between the size of the lesion and time of evolution (r s = 0.3079, p = 0.03, and inverse correlation between size of the lesion and abundance of amastigotes (r s = -0.2467, p = 0.03. In view of the complexity of clinical and histopathological findings, cell-mediated immune response of the disease related to clinical and histopathological features, as so genetic background should be studied.La Leishmaniosis Cutánea Localizada (LCL mejor conocida como "úlcera del chiclero" en el sureste de México fue descrita por SEIDELIN en 1912. Desde entonces la región selvática de la península de Yucatán ha sido identificada como un área endémica de LCL. En el presente estudio se analizaron 73 biopsias de lesiones de casos de LCL causados por Leishmania (Leishmania mexicana con el fin de: 1 examinar la respuesta a nivel tisular; y 2 relacionar las manifestaciones de esta respuesta con ciertas características de la presentación clínica. Con base en la clasificación histopatológica de Magalhães el patrón histopatológico más frecuente se caracterizó por la presencia de granuloma desorganizado y

  13. Uveitis as a Result of MAP Kinase Pathway Inhibition

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    Lavnish Joshi

    2013-11-01

    Full Text Available We report the case of a patient treated with dabrafenib and trametinib (mitogen-activated protein kinase pathway inhibitors for stage 3b cutaneous melanoma who developed bilateral uveitis. Although there have been reports of ocular side effects with this class of drugs, uveitis has not been previously reported to the best of our knowledge. This case indicates the wide range of side effects that can be seen with the newer targeted biological therapies.

  14. Increased CD40 ligand in patients with acute anterior uveitis

    DEFF Research Database (Denmark)

    Øgard, Carsten; Sørensen, Torben Lykke; Krogh, Erik

    2005-01-01

    The inflammatory response in acute anterior uveitis (AU) is believed to be primarily mediated by autoreactive T-cells. We wanted to evaluate whether the T-cell activation marker CD40 ligand is involved in the AU immunopathogenesis.......The inflammatory response in acute anterior uveitis (AU) is believed to be primarily mediated by autoreactive T-cells. We wanted to evaluate whether the T-cell activation marker CD40 ligand is involved in the AU immunopathogenesis....

  15. Association of Cryptogenic Organizing Pneumonia in Bilateral Anterior Uveitis

    OpenAIRE

    Kaori Fujimoto; Miki Hiraoka; Shuichiro Inatomi; Hiroshi Ohguro

    2014-01-01

    Two female patients with histories of cancer who showed cryptogenic organizing pneumonia (COP) complications and bilateral anterior uveitis with hypopyon were examined. Both patients had suffered from COP and received intermitted systemic corticosteroid administration (SCA). The first patient, a 65-year-old woman with a history of breast cancer, showed bilateral uveitis with hypopyon. The topical corticosteroid treatment was ineffective. After SCA for the treatment of COP was started, the hyp...

  16. Fotossensibilização primária em eqüídeos e ruminantes no semi-árido causada por Froelichia humboldtiana (Amaranthaceae Primary photosensitization in equidae and ruminants in the Brazilian semi-arid caused by Froelichia humboldtiana (Amaranthaceae

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    Luciano A. Pimentel

    2007-01-01

    Full Text Available Fotossensibilização é freqüente em eqüinos no semi-árido da região Nordeste, mas jumentos, mulas, ovinos e bovinos são, também, afetados. A dermatite afeta, principalmente, áreas de pele despigmentadas e os animais se recuperam após serem retirados das pastagens. Para comprovar a etiologia da enfermidade Froelichia humboldtiana (Roem. et Schult. Seub., coletada no campo foi administrada no mesmo dia da colheita ou após ser mantida em refrigerador por 1-4 dias, por períodos de 30 ou mais dias, ad libitum como único alimento, a 2 jumentos e um ovino branco e, como único alimento volumoso, a um eqüino branco. Esses animais não manifestaram sinais clínicos e as atividades séricas de gama-glutamiltransferase (GGT, aspartato-aminotransferase (AST e alanino-aminotransferase (ALT ficaram dentro dos valores normais. Em outro experimento, um ovino foi colocado a pastar diariamente, durante o dia, preso por uma corda em uma área que tinha exclusivamente F. humboldtiana, por um período de 26 dias. Lesões características de fotossensibilização foram observadas 4-5 dias após o início do experimento. Após cessar o consumo da planta, no 26º dia, o ovino recuperou-se totalmente em 30 dias. Em outro experimento, 4 ovinos foram também colocados, presos por cordas, na mesma área. Outros 4 permaneceram como controles em uma pastagem vizinha, mas sem F. humboldtiana. Lesões de pele, características de fotossensibilização foram observadas após 11-25 dias de consumo de F. humboldtiana. As atividades séricas de AST e GGT, e os níveis de bilirrubina sérica permaneceram dentro dos valores normais. No final do período de permanência em pastagens de F. humboldtiana, 2 ovinos foram abatidos e 2 foram retirados da pastagem. Os que foram abatidos não apresentaram lesões macroscópicas nem histológicas do fígado; os outros dois se recuperaram das lesões da pele 17 e 20 dias após o fim do pastejo. Uma égua e seu potro foram

  17. Identificação de enfermidades agudas causadas por animais e plantas em ambientes rurais e litorâneos: auxílio à prática dermatológica Identification of acute diseases caused by animals and plants in wild environments: contribution to dermatologic practice

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    Vidal Haddad Junior

    2009-08-01

    Full Text Available FUNDAMENTOS: Nos últimos anos, existe um aumento progressivo do contato de moradores urbanos com ambientes selvagens devido a atividades de lazer. Com isso, algumas dermatites pouco conhecidas podem ser observadas nas clínicas privadas e ambulatórios dermatológicos, especialmente nos inícios de semana e finais de férias. OBJETIVOS: Obter e fornecer informações para dermatologistas sobre o problema. PACIENTES E MÉTODOS: O autor observou, em adultos e crianças, dermatites agudas associadas a plantas ou animais em Ubatuba, cidade litorânea de São Paulo, por dois meses (junho/julho de 2006 e na Faculdade de Medicina de Botucatu, também por dois meses (junho/julho de 2007. RESULTADOS: Foram observados 25 pacientes na área rural e 43 na área litorânea nas condições estabelecidas. Em áreas rurais, foram mais observadas fitofotodermatites e picadas de insetos, enquanto em áreas litorâneas traumas por ouriços-do-mar e fitofotodermatites predominaram; entretanto, em ambas as áreas ocorreram outros acidentes de difícil identificação na prática diária. CONCLUSÕES: Devemos estar atentos ao fato de o paciente procurar o dermatologista somente após as fases agudas dos acidentes. Informações sobre as enfermidades mais comuns e suas características podem ser muito úteis para a prática nos consultórios. O autor sugere uma tabela algorítmica para auxílio diagnóstico.BACKGROUND: In recent years, there has been increasing contact between human beings that live in urban regions and the wild environment due to a series of activities. As a result, some poorly known dermatitis may present in private and dermatological clinics, especially early in the week and at the end of vacation periods. OBJECTIVES: To obtain and provide information for dermatologists on the problem. PATIENTS AND METHODS: The author observed adult and pediatric patients with acute dermatitis associated with plants or animals in Ubatuba, coastal city of Sao Paulo

  18. Efeito de fungicidas cúpricos, aplicados isoladamente ou em combinação com mancozeb, na expressão de sintomas de fitotoxicidade e controle da ferrugem causada por Puccinia psidii em goiabeira Effect of copper fungicides, sprayed alone or in combination with mancozeb, in expression of phytotoxicity symptoms and rust control caused by Puccinia psidii in guava

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    Antonio de Goes

    2004-08-01

    Full Text Available Dois experimentos foram conduzidos em pomares de goiabeira 'Paluma', nos municípios de Monte Alto e Vista Alegre do Alto-SP. No primeiro experimento, avaliou-se o efeito de formulações de fungicidas cúpricos, aplicados isoladamente e em mistura com mancozeb, quanto ao efeito fitotóxico em botões florais e em frutos de goiabeira, em três estádios de desenvolvimento. No segundo experimento, foram avaliados os mesmos fungicidas usados no primeiro experimento, sendo, porém, acrescido do tratamento constituído por tebuconazole, cujo alvo foi sua eficiência no controle da ferrugem. No primeiro experimento, verificou-se que nenhum dos fungicidas testados causou abortamento de flores ou outros tipos de sintomas de fitotoxicidade em frutos de tamanho inferior a 15 mm de diâmetro. Contrariamente, estes fungicidas, quando aplicados isoladamente, em frutos entre 25 a 35 mm de diâmetro, causaram sintomas severos de fitotoxicidade. Em frutos de tamanho superior a 40 mm de diâmetro, estes fungicidas causaram sintomas de fitotoxicidade de níveis leves a moderados. A combinação de fungicidas cúpricos com mancozeb causou sintomas de fitotoxicidade em níveis leves, enquanto com mancozeb isoladamente não foram verificados sintomas de fitotoxicidade. No segundo experimento, verificou-se que os fungicidas cúpricos, aplicados isoladamente, foram eficientes no controle da ferrugem da goiabeira, apresentando eficiência comparável ao tratamento-padrão representado por tebuconazole. Esta eficiência foi também observada mediante o emprego da combinação mancozeb e óxido cuproso ou hidróxido de cobre.Two experiments were carried out in guava orchards cv. 'Paluma' at Monte Alto and Vista Alegre do Alto/SP. In Experiment 1 it was used copper fungicides applied alone and in combination with mancozeb to evaluate the effect of phytotoxicity on floral buds and guava fruits in three developmental stages. In Experiment 2 it was used the same fungicides

  19. Lipid peroxidation in experimental uveitis: sequential studies.

    Science.gov (United States)

    Goto, H; Wu, G S; Chen, F; Kristeva, M; Sevanian, A; Rao, N A

    1992-06-01

    Previously we have detected the occurrence of retinal lipid peroxidation initiated by phagocyte-derived oxygen radicals in experimental autoimmune uveitis (EAU). In the current studies, the confirmation of inflammation-mediated lipid peroxidation was proceeded further to include measurement of multiple parameters, including conjugated dienes, ketodienes, thiobarbituric acid reactive substances and fluorescent chromolipids. The assay for myeloperoxidase, a measure for the number of polymorphonuclear leukocytes in the inflammatory sites was also carried out. The levels of all these parameters were followed through the course of EAU development. The sequential evaluation of histologic changes using both light and electron microscopy was also carried out and the results were correlated with lipid peroxidation indices. These data suggest that the retinal lipid peroxidation plays a causative role in the subsequent retinal degeneration.

  20. Equine recurrent uveitis: the European viewpoint.

    Science.gov (United States)

    Spiess, B M

    2010-03-01

    Equine recurrent uveitis (ERU) has always been and still is an important disease with a significant impact on the horse industry in Europe, with a prevalence of 8-10%. The need to understand and manage the disease has spurred the development of veterinary ophthalmology in general, although the aetiology of the disease remains the subject of intense discussion. It is most probably an autoimmune disease triggered, at least in Europe, in the majority of cases by Leptospira spp. The therapy of ERU has evolved over the centuries from various methods of bloodletting to rational medical therapy using mydriatics and steroidal and nonsteroidal anti-inflammatory drugs, to surgical therapies, such as vitrectomy or implantation of cyclosporin-releasing devices. In Europe, pars plana vitrectomy in horses testing positive for Leptospira spp. appears to be the most successful form of therapy at the present time.

  1. Anterior uveitis and diabetes mellitus: immunological study.

    Science.gov (United States)

    Castagna, I; Famà, F; Salmeri, G

    1995-01-01

    The association between anterior uveitis (AU) and diabetes mellitus (DM) has always been known. The purpose of this study was to estimate the incidence of this association and to consider a possible role of the cell-mediated immune system. During the years 1989-1992, 196 diabetics (66 patients affected by type I DM and 130 by type II DM) were studied. The study of the lymphocytic subsets and the measurement of the circulating immunocomplexes and autoantibodies (ANA, AMA, ADNA, ASMA, APCA) were carried out, and the results were compared with those of a control group. The results underline the correlation between AU and type I DM. Many immunological reactions could play a crucial role: the high levels of CD8 subsets found could be an expression of the unstable lymphocytic equilibrium.

  2. Ocorrência de surto de tuberculose causada pelo complexo Mycobacterium tuberculosis em uma criação de suínos

    OpenAIRE

    Schwarz, Patrícia; Silva,Luís Eduardo da; Marchetti, Alexandre Nólibos; Bortolozzo,Fernando Pandolfo; Driemeier, David; Dias,Cleandro Pazinato; Fernandes, Joaquim Cesar Teixeira; Wentz, Ivo; Cardoso,Marisa Ribeiro de Itapema

    2002-01-01

    A tuberculose continua sendo um importante problema de saúde pública, por ser uma zoonose que tornou-se reemergente devido, principalmente, a grande incidência entre portadores de imunodeficiências. A tuberculose, causada por micobactérias do grupo mamífero, em suínos criados em sistemas comerciais, é uma doença raramente encontrada. Neste trabalho, foram necropsiados três animais, provenientes de uma granja de suínos com aproximadamente 90 animais alimentados com resíduos alimentares. Alguns...

  3. Autoimmune uveitis: clinical, pathogenetic, and therapeutic features.

    Science.gov (United States)

    Prete, Marcella; Dammacco, Rosanna; Fatone, Maria Celeste; Racanelli, Vito

    2016-05-01

    Autoimmune uveitis (AU), an inflammatory non-infectious process of the vascular layer of the eye, can lead to visual impairment and, in the absence of a timely diagnosis and suitable therapy, can even result in total blindness. The majority of AU cases are idiopathic, whereas fewer than 20 % are associated with systemic diseases. The clinical severity of AU depends on whether the anterior, intermediate, or posterior part of the uvea is involved and may range from almost asymptomatic to rapidly sight-threatening forms. Race, genetic background, and environmental factors can also influence the clinical picture. The pathogenetic mechanism of AU is still poorly defined, given its remarkable heterogeneity and the many discrepancies between experimental and human uveitis. Even so, the onset of AU is thought to be related to an aberrant T cell-mediated immune response, triggered by inflammation and directed against retinal or cross-reactive antigens. B cells may also play a role in uveal antigen presentation and in the subsequent activation of T cells. The management of AU remains a challenge for clinicians, especially because of the paucity of randomized clinical trials that have systematically evaluated the effectiveness of different drugs. In addition to topical treatment, several different therapeutic options are available, although a standardized regimen is thus far lacking. Current guidelines recommend corticosteroids as the first-line therapy for patients with active AU. Immunosuppressive drugs may be subsequently required to treat steroid-resistant AU and for steroid-sparing purposes. The recent introduction of biological agents, such as those targeting tumor necrosis factor-α, is expected to remarkably increase the percentages of responders and to prevent irreversible sight impairment. This paper reviews the clinical features of AU and its crucial pathogenetic targets in relation to the current therapeutic perspectives. Also, the largest clinical trials

  4. Clinical Characteristics of Fuchs’ Uveitis Syndrome

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    Pınar Çakar Özdal

    2016-04-01

    Full Text Available Objectives: To evaluate the clinical and demographic properties of Fuchs’ uveitis syndrome (FUS in Turkish patients. Materials and Methods: The medical records of 161 patients with FUS followed in the Uveitis Division of Ulucanlar Eye Hospital between 1996 and 2014 were respectively reviewed. The mean age at diagnosis, sex, the number of affected eyes, follow-up period, clinical findings at presentation, complications during the follow-up period, medical and surgical treatments, and best corrected visual acuity at the initial and final visits were recorded. Results: The study included 171 eyes of 161 patients diagnosed with FUS. Of the patients, 94 (58.4% were female and 67 (41.6% were male. The mean age at presentation was 35.2±11.0 (11-65 years. The mean follow-up period was 23.5±32.8 (2-216 months. Ten (6.2% patients had bilateral involvement. The most common symptoms at presentation were decreased visual acuity or blurred vision in 63 (39.1% and floaters in 19 (11.8% patients. Clinical findings at presentation included diffuse small, round, white keratic precipitates in 128 (74.8% eyes, anterior chamber reaction in 82 (47.9%, vitreous cells in 122 (71.3%, heterochromia in 47 (27.4% and iris nodules in 32 (18.7% eyes. During the follow-up period, elevated intraocular pressure occured in 31 (18.1% eyes and the most common complication was cataract development (89 eyes, 52.0%. Conclusion: Heterochromia was observed in 27.4% of patients in our study. However, the diffuse small, round keratic precipitates, low-grade anterior chamber reaction and varying degrees of vitreous reaction are more common clinical characteristics that are helpful in making the diagnosis.

  5. Clinical Characteristics of Fuchs’ Uveitis Syndrome

    Science.gov (United States)

    Nalçacıoğlu, Pınar; Çakar Özdal, Pınar; Şimşek, Mert

    2016-01-01

    Objectives: To evaluate the clinical and demographic properties of Fuchs’ uveitis syndrome (FUS) in Turkish patients. Materials and Methods: The medical records of 161 patients with FUS followed in the Uveitis Division of Ulucanlar Eye Hospital between 1996 and 2014 were respectively reviewed. The mean age at diagnosis, sex, the number of affected eyes, follow-up period, clinical findings at presentation, complications during the follow-up period, medical and surgical treatments, and best corrected visual acuity at the initial and final visits were recorded. Results: The study included 171 eyes of 161 patients diagnosed with FUS. Of the patients, 94 (58.4%) were female and 67 (41.6%) were male. The mean age at presentation was 35.2±11.0 (11-65) years. The mean follow-up period was 23.5±32.8 (2-216) months. Ten (6.2%) patients had bilateral involvement. The most common symptoms at presentation were decreased visual acuity or blurred vision in 63 (39.1%) and floaters in 19 (11.8%) patients. Clinical findings at presentation included diffuse small, round, white keratic precipitates in 128 (74.8%) eyes, anterior chamber reaction in 82 (47.9%), vitreous cells in 122 (71.3%), heterochromia in 47 (27.4%) and iris nodules in 32 (18.7%) eyes. During the follow-up period, elevated intraocular pressure occured in 31 (18.1%) eyes and the most common complication was cataract development (89 eyes, 52.0%). Conclusion: Heterochromia was observed in 27.4% of patients in our study. However, the diffuse small, round keratic precipitates, low-grade anterior chamber reaction and varying degrees of vitreous reaction are more common clinical characteristics that are helpful in making the diagnosis. PMID:27800260

  6. Immunohistochemical studies in equine recurrent uveitis (ERU).

    Science.gov (United States)

    Romeike, A; Brügmann, M; Drommer, W

    1998-11-01

    Despite extensive clinical research, the etiology of equine recurrent uveitis (ERU) is still unknown. After an immunologic pathogenesis was established in recurrent uveitis in humans, a similar pathogenic mechanism was assumed to exist in ERU. To investigate whether immunopathologic mechanisms are involved in ERU, 20 eyes of 15 horses with ERU were examined immunohistochemically with a T cell marker, B cell marker, and anti-major histocompatibility complex (MHC) class II antibodies. Twenty-six eyes of 20 horses were used for investigation of MHC class II antigen expression in normal equine eyes. In 18 eyes of 14 horses, the number of T cells in the inflammatory cell population within the uvea was assessed. In 16/18 eyes (89%), the T lymphocyte fraction was > 70%. This cell population was distributed mostly in a diffuse manner throughout the uvea and also within the mantle zone of follicular lymphocytic aggregates. Foci of B lymphocytes could be found within the center of follicular aggregates in three eyes. The expression of MHC class II antigen on resident ocular cells was evaluated in 10 eyes of six horses with ERU. An increase of MHC class II antigen expression in the trabecular meshwork and on the nonpigmented ciliary epithelium was noted as was a deviant expression on proliferating Müller cells and retinal pigment epithelial cells. The predominance of T cells in the inflammatory infiltrates supports the central role of a cell-mediated immune response. Furthermore, the observation of a deviant MHC class II expression on resident ocular cells suggests that aberrant immune regulation may play a role in the pathogenesis of ERU.

  7. Omeprazole and misoprostol for preventing gastric mucosa effects caused by indomethacin and celecoxib in rats Omeprazol e misoprostol na prevenção de lesões de mucosa gástrica causadas por indometacina e celecoxib em ratos

    Directory of Open Access Journals (Sweden)

    Míriam Elias Cavallini

    2006-06-01

    ástrica com omeprazol e misoprostol. MÉTODOS: A amostragem consistiu 150 ratos machos da raça Wistar, com peso médio de 200g, divididos em quatro grupos, a saber: grupo A, subdividido em grupos A1 e A2 - pré-tratamento com omeprazol (20 mg/rato durante sete dias, e no oitavo dia receberam o AINEs, sendo A1 (20 ratos receberam celecoxib (1mg/rato e A2 (20 ratos receberam indometacina (12,5mg/rato. O grupo B, subdividido em grupo B1 e B2 - pré-tratamento com misoprostol (20ìg/rato durante sete dias e no oitavo dia receberam AINEs, sendo B1 (20 ratos receberam celecoxib (1mg/rato e B2 (20 ratos receberam indometacina (12,5mg/rato. O grupo C não recebeu citoproteção durante sete dias e no oitavo dia recebeu AINEs, sendo C1 (20 ratos receberam celecoxib (1mg/rato , C2 (20ratos receberam indometacina (12,5mg/rato, C3 (20 ratos receberam celecoxib e grupo D - grupo controle, no qual dez ratos foram observados recebendo ração e água ad libitum. A seguir, no 9º dia (de todos os grupos, os estômagos eram removidos e avaliados macro e microscopicamente para a identificação das lesões gástricas. RESULTADOS: Na análise macroscópica, os grupos A2, B2 e C2 apresentaram número de lesões por cm²/animal significativamente elevados, sendo respectivamente 18,55 lesões por cm²/animal, 16,25 lesões por cm²/animal e 13,55 lesões por cm²/animal. Na análise microscópica, a porcentagem da mucosa com lesão mostrou diferença significativa entre os grupos A1, B1, C1 quando comparados com os grupos A2, B2 e C2 (p<0,0001. Os resultados da média da extensão/lesão e da média da profundidade das lesões não mostraram diferenças estatísticas significativas entre os grupos A2, B2 e C2. A média do edema mostrou diferença estatística significativa entre os grupos A2 e D; B2 e C2 e entre C2 e D (p<0,05. CONCLUSÕES: A indometacina na concentração empregada provoca número significativo de lesões macro e microscópicas na mucosa gástrica de ratos quando comparadas ao

  8. Chlorotic spots on Clerodendrum, a disease caused by a nuclear type of Brevipalpus (Acari:Tenuipalpidae transmitted virus Mancha clorótica do Clerodendrum, uma enfermidade causada por um vírus do tipo nuclear, transmitido pelo ácaro Brevipalpus phoenicis (Acari:Tenuipalpidae

    Directory of Open Access Journals (Sweden)

    Elliot Watanabe Kitajima

    2008-02-01

    por ácaros Brevipalpus (VTB. Brevipalpus phoenicis coletados de C. x speciosum sintomático e transferidos para plantas sadias de C. x speciosum reproduziram as lesões. O ácaro também transmitiu o patógeno para C. thomsonae, Gomphrena globosa, Hibiscus cannabinus, H. coccineus, H. schizopetalus, Salvia leucantha, Spathiphyllum wallasi e Tetragonia expansa, as quais exibiram manchas cloróticas e/ou necróticas. O vírus também foi transmitido mecanicamente para Chenopodium amaranticolor, C. quinoa, G. globosa, H. cannabinus, H. coccineus e T. expansa, além de C. x speciosum. Plantas de C. amaranticolor e C. quinoa mantidas a 28 - 30ºC desenvolveram infecção sistêmica. Em todos os tecidos sintomáticos das plantas-teste inoculadas, examinados ao microscópio eletrônico, foram encontrados efeitos citopáticos do tipo nuclear causado por VTB. O vírus foi purificado a partir de folhas com infecção sistêmica de C. amaranticolor e C. quinoa. Injeções de preparações purificadas em coelho geraram um anti-soro policlonal que reagiu especificamente com o antígeno homólogo em teste de ELISA. As evidências obtidas indicam que as manchas cloróticas do Clerodendrum estão associadas a um VTB do tipo nuclear, tentativamente denominado de vírus da mancha clorótica do Clerodendrum (Clerodendrum chlorotic spot virus- ClCSV.

  9. Glycemic acute changes in type 2 diabetics caused by low and high glycemic index diets Las variaciones de la glucosa aguda en individuos con diabetes tipo 2 causada por las dietas de bajo y alto índice glucémico

    Directory of Open Access Journals (Sweden)

    C. E. Gonçalves Reis

    2011-06-01

    Full Text Available Introduction: Low-glycemic index diets may improve the glycemic control in type 2 diabetes but the debate over their effectiveness continues. Objectives: To test the effects of low-glycemic index diets on acute glycemic control (2 days by measuring capillary blood glucose in patients with type 2 diabetes. Methods: This was a crossover randomized clinical trial with 12 type 2 diabetics which were randomly divided into 2 groups and targeted the following draft diets for low and high glycemic index (LGI and HGI for 2 consecutive days in 2 consecutive weeks. Group 1 followed an LGI diet in week 1 and an HGI diet in week 2, group 2 adopted the contrary. They were oriented to maintain medication and lifestyle and to follow the recommendations. Measurements were made of glycemia capillaries in 2 days (fasting, before lunch, post-prandial lunch and before dinner and one last in fasting on day 3. A food record during the days and the counting of carbohydrates meals was made. The software SigmaStat (version 2.03 was used, with a statistical significance criterion of p Introducción: Dietas de bajo índice glucémico pueden mejorar el control glucémico en la diabetes tipo 2, pero sigue el debate sobre su eficacia. Objetivos: Evaluar los efectos de las dietas bajas en el índice glucémico en el control glucémico agudo (2 días por la medición de glucosa en sangre capilar en pacientes con diabetes tipo 2. Métodos: Se realizó un ensayo clínico cruzado y aleatorizado con 12 pacientes diabéticos tipo 2. Fueron divididos en 2 grupos: dietas de bajo y alto índice glucémico (BIG y AIG. Las dietas fueron consumidas por 2 días consecutivos, en 2 semanas distintas. Para el grupo 1 fue administrado la dieta BIG en la semana 1 seguida de la dieta AIG en la semana 2. En contrario se dio para el grupo 2. Se recomendó a los pacientes que mantuviesen la medicación y el estilo de vida estables. Se midió y registro la glucemia capilar en 2 días (en ayunas

  10. Reaction of arracacha genotypes to the root soft rot caused by Pectobacterium chrysanthemi Reação de genótipos de mandioquinha-salsa à podridão-mole das raízes causada por Pectobacterium chrysanthemi

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    Gilmar Paulo Henz

    2005-01-01

    Full Text Available The purpose of this paper was to screen thirty-two arracacha genotypes for their reaction to root soft rot. Twenty roots of each genotype were inoculated with two Pectobacterium chrysanthemi isolates in a randomized experiment (10 roots/isolate. After inoculation, roots were individually wrapped with PVC film and kept at 26ºC in closed plastic bags. Soft rot lesions were recorded after 36 hours and genotypes were grouped in four classes of susceptibility by cluster analysis: 10 were less susceptible, 16 intermediate, 3 susceptible and 3 very susceptible. All the tested arracacha genotypes showed only variation in the degree of susceptibility.O objetivo deste trabalho foi avaliar a reação de 32 genótipos de mandioquinha-salsa à podridão-mole das raízes. Vinte raízes de cada genótipo foram inoculadas com dois isolados de Pectobacterium chrysanthemi em um experimento casualizado (10 raízes/isolado. Após a inoculação, as raízes foram embaladas com filmes de PVC e mantidas a 26ºC em sacos de plástico. As lesões de podridão-mole foram avaliadas após 36 horas e os genótipos agrupados em quatro classes de suscetibilidade por análise de agrupamento: 10 foram menos suscetíveis, 16 intermediários, 3 suscetíveis e 3 muito suscetíveis. Todos os genótipos avaliados demonstraram apenas variação no grau de suscetibilidade.

  11. Ocular hypertension and hypotony as determinates of outcomes in uveitis

    Science.gov (United States)

    Aman, Rabia; Engelhard, Stephanie B; Bajwa, Asima; Patrie, James; Reddy, Ashvini K

    2015-01-01

    Purpose To assess ocular hypertension (OHT) and hypotony as outcomes of uveitis in patients managed in a mid-Atlantic tertiary care center. Methods Retrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014. Results A total of 442 patients (582 eyes) with uveitis were identified and included in the study. The patient population was 57.0% female. Overall, 61.9% were Caucasian and 26.6% were African American. Mean age was 46.8 years. Overall, 11.5% of the eyes had OHT at initial visit, and 7.9% had OHT at final visit (P=0.035). For each additional decade of life, the odds that an eye had OHT were elevated by a factor of 1.15 (95% confidence interval [CI]: [1.02, 1.30], P=0.027) at initial visit and by a factor of 1.15 (95% CI: [1.00, 1.32], P=0.055) at final visit. The odds that an anterior uveitis eye had OHT were greater by a factor of 2.50 (95% CI: [1.22, 5.14], P=0.013) than the odds for a nonanterior uveitis eye at initial visit and greater by a factor of 2.61 (95% CI: [1.24, 5.50], P=0.011) at final visit. For each additional 0.5 logarithm of the minimum angle of resolution increase in initial visual acuity, the odds that an affected eye had OHT were elevated by a factor of 1.18 (95% CI: [1.00, 1.39], P=0.047) at initial visit and 1.23 (95% CI: [0.99, 1.54], P=0.065) at final visit. Overall, 21 of 582 eyes (3.6%) were hypotonous initially, while 24 of 582 eyes (4.1%) were hypotonous at final follow-up (P=0.631). Conclusion OHT was associated with increasing age, anterior uveitis, and poor presenting visual acuity. Ocular hypotony was more common in anterior uveitis than in nonanterior uveitis. Fluctuations in intraocular pressure are an important cause of visual impairment in patients with uveitis. Careful monitoring of all uveitis patients, and especially those most at risk for fluctuations in intraocular pressure, can preserve vision and improve patient outcomes. PMID:26672771

  12. Pathogenesis of innate immunity and adaptive immunity in the mouse model of experimental autoimmune uveitis.

    Science.gov (United States)

    Bi, Hong-Sheng; Liu, Zheng-Feng; Cui, Yan

    2015-05-01

    Experimental autoimmune uveitis, a well-established model for human uveitis, is similar to human uveitis in many pathological features. Studies concerning the mechanisms of experimental autoimmune uveitis would cast a light on the pathogenesis of human uveitis as well as the search for more effective therapeutic agents. The cellular components of innate immunity include natural killer cells, gamma delta T lymphocytes, antigen-presenting dendritic cells, phagocytic macrophages, and granulocytes. It is believed that T cells are central in the generation of human uveitis. It has already become clear that CD4(+) effecter cells that predominantly produce interleukin-17 (the so-called Th17 cells) may play an important role in uveitis. In addition, the occurrence and recurrence of uveitis depends on a complex interplay between the elements of innate and adaptive immunity.

  13. Tumornekrosefaktor alpha-haemning som led i behandling af uveitis hos børn

    DEFF Research Database (Denmark)

    Fledelius, Hans Callø; Nielsen, Susan M; Nissen, Kamilla Rothe

    2007-01-01

    To present our experience with anti-TNFalpha treatment of juvenile idiopatic arthritis (JIA) associated uveitis.......To present our experience with anti-TNFalpha treatment of juvenile idiopatic arthritis (JIA) associated uveitis....

  14. HLA-B27-ASSOCIATED UVEITIS: EPIDEMIOLOGY, CLINICAL PICTURE, AND COMPLICATIONS

    Directory of Open Access Journals (Sweden)

    T. V. Dubinina

    2014-01-01

    Full Text Available Anterior uveitis is the most common form of intraocular inflammation. Among them, HLA-B27-associated uveitis occupies one of the leading places, which may be an independent disease or one of the manifestations of spondy- loarthritis (SA. The paper considers the general issues of the nomenclature and classification of uveitis, by using the classification criteria of the International Uveitis Study Group and the Standardization of Uveitis Nomenclature Workshop. The epidemiological aspects of uveitis are described. Emphasis is laid on a difference in the detection rate of uveitis in different countries, in men and women, as well as in different forms of SA. The clinical features of SA- associated uveitis and its complications are discussed. 

  15. Demographic and clinical features of pediatric uveitis at a tertiary referral center in Iran

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    Mansour Rahimi

    2016-01-01

    Conclusions: Uveitis in the majority of children had an insidious onset and was chronic. Over half the patients had a specific diagnosis. Idiopathic cases were more common in the intermediate uveitis group.

  16. Papel da lipoperoxidação na intensificação da remodelação causada pelo betacaroteno após o infarto Rol de la lipoperoxidación en la intensificación de la remodelación ocasionada por el betacaroteno tras infarto Role of lipoperoxidation in the remodeling intensification induced by beta-carotene after infarction

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    Paula S. Azevedo

    2009-07-01

    Full Text Available FUNDAMENTO: Os mecanismos envolvidos na maior remodelação causada pelo betacaroteno após o infarto são desconhecidos. OBJETIVO: Analisar o papel da lipoperoxidação na remodelação ventricular após o infarto do miocárdio, em ratos suplementados com betacaroteno. MÉTODOS: Ratos foram infartados e distribuídos em dois grupos: C (controle e BC (500mg/kg/dieta. Após seis meses, foram realizados ecocardiograma e avaliação bioquímica. Utilizamos o teste t, com significância de 5%. RESULTADOS: Os animais do grupo BC apresentaram maiores médias das áreas diastólicas (C = 1,57 ± 0,4 mm²/g, BC = 2,09 ± 0,3 mm²/g; p FUNDAMENTO: Los mecanismos implicados en la mayor remodelación ocasionada por betacaroteno tras el infarto son desconocidos. OBJETIVO: Analizar el rol que juega la lipoperoxidación en la remodelación ventricular tras el infarto de miocardio, en ratas suplementadas con betacaroteno. MÉTODOS: Se había inducido a un infarto a las ratas y se las distribuyó en grupos: C (control y BC (500mg/kg/dieta. Tras seis meses, se realizaron ecocardiograma y evaluación bioquímica. Utilizamos la prueba t, con significancia del 5%. RESULTADOS: Los animales del grupo BC presentaron mayores promedios de las áreas diastólicas (C = 1,57 ± 0,4 mm²/g, BC = 2,09 ± 0,3 mm²/g; p BACKGROUND: The mechanisms involved in the biggest remodeling caused by the post-infarct beta-carotene are unknown. OBJECTIVE: To analyze the role of lipoperoxidation in the ventricular remodeling after infarct of the myocardium in rats supplemented with beta-carotene. METHODS: Rats were infarcted and divided into two groups: C (control and BC (500mg/kg/regimen. After six months, echocardiogram and biochemical evaluation were performed. The t test was used, with 5% significance. RESULTS: The animals from BC group presented highest means of the diastolic (C = 1.57 ± 0.4 mm²/g, BC = 2.09 ± 0.3 mm²/g; p < 0.001 and systolic (C = 1.05 ± 0.3 mm²/g, BC = 1.61

  17. Insuficiência respiratória aguda causada por pneumonia em organização secundária à terapia antineoplásica para linfoma não Hodgkin Acute respiratory failure caused by organizing pneumonia secondary to antineoplastic therapy for non-Hodgkin's lymphoma

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    Adriell Ramalho Santana

    2012-12-01

    Full Text Available Doenças difusas do parênquima pulmonar pertencem a um grupo de doenças de evolução geralmente subaguda ou crônica, mas que podem determinar insuficiência respiratória aguda. Paciente masculino, 37 anos, em terapia para linfoma não Hodgkin, admitido com tosse seca, febre, dispneia e insuficiência respiratória aguda hipoxêmica. Iniciadas ventilação mecânica e antibioticoterapia, porém houve evolução desfavorável. Tomografia computadorizada de tórax mostrava opacidades pulmonares em "vidro fosco" bilaterais. Devido ao paciente ter feito uso de três drogas relacionadas à pneumonia em organização (ciclofosfamida, doxorrubicina e rituximabe e quadros clínico e radiológico serem sugestivos, iniciou-se pulsoterapia com metilprednisolona com boa resposta. Pneumonia em organização pode ser idiopática ou associada a colagenoses, drogas e neoplasias, e geralmente responde bem a corticoterapia. O diagnóstico é anatomopatológico, mas condições clínicas do paciente não permitiam a realização de biópsia pulmonar. Pneumonia em organização deve ser diagnóstico diferencial em pacientes com aparente pneumonia de evolução desfavorável ao tratamento antimicrobiano.Interstitial lung diseases belong to a group of diseases that typically exhibit a subacute or chronic progression but that may cause acute respiratory failure. The male patient, who was 37 years of age and undergoing therapy for non-Hodgkin's lymphoma, was admitted with cough, fever, dyspnea and acute hypoxemic respiratory failure. Mechanical ventilation and antibiotic therapy were initiated but were associated with unfavorable progression. Thoracic computed tomography showed bilateral pulmonary "ground glass" opacities. Methylprednisolone pulse therapy was initiated with satisfactory response because the patient had used three drugs related to organizing pneumonia (cyclophosphamide, doxorubicin and rituximab, and the clinical and radiological symptoms were

  18. Avaliação de produtos químicos comerciais, in vitro e in vivo, no controle da doença foliar, mancha branca do milho, causada por Pantoea ananatis Evaluation of commercial chemical products, in vitro and in vivo in the control of foliar disease, maize white spot, caused by Pantoea ananais

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    Cleide Aparecida Bomfeti

    2007-03-01

    Full Text Available Uma bactéria identificada como Pantoea ananatis foi recentemente isolada de lesões jovens da doença mancha branca do milho de plantas naturalmente infectadas. Esta bateria reproduziu sintomas semelhantes aos da doença quando inoculada em plantas de milho em casa de vegetação. Estudos anteriores realizados por outros autores demonstraram que o controle desta doença em condições de campo foi obtido pelo uso de fungicidas, principalmente o Mancozeb, nas fases iniciais de seu desenvolvimento. O objetivo deste estudo foi avaliar a freqüência de isolamento da bactéria P. ananatis a partir de plantas infectadas coletadas na região de Londrina, Estado do Paraná, e reproduzir sintomas da doença através de inoculações artificiais em plantas de milho em casa de vegetação. Utilizando os produtos químicos testados anteriormente por outros autores para o controle desta doença a campo, foi também objetivo deste trabalho avaliar o potencial destes produtos na inibição da bactéria tanto em condições de laboratório como em condições de infecção natural. Os resultados mostraram que P. ananatis foi isolada em 40% das lesões jovens coletadas a campo e quando inoculada em casa de vegetação sob condições controladas reproduziu sintomas semelhantes aos observados a campo. Entre os produtos químicos testados, o fungicida Mancozeb mostrou-se eficiente no controle da doença a campo, em concordância com os relatos anteriores. Este produto inibiu completamente o crescimento da bactéria em laboratório, explicando os resultados obtidos a campo. Os demais produtos não foram eficientes no controle a campo e eles também não inibiram a bactéria em laboratório. Estes resultados representam evidências adicionais de que a bactéria P. ananatis é o agente causal da doença mancha branca do milho.A bacterium identified as Pantoea ananatis was recently isolated from young lesions of the disease maize white spot from infected plants in

  19. Treatment of noninfectious posterior uveitis with dexamethasone intravitreal implant

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    Jane S Myung

    2010-12-01

    Full Text Available Jane S Myung, Grant D Aaker, Szilárd KissDepartment of Ophthalmology, Weill Cornell Medical Center, New York, NY, USAPurpose: To report our experience with dexamethasone 0.7 mg sustained-release intravitreal implant (Ozurdex®; Allergan, Inc, Irvine, CA in noninfectious posterior uveitis.Methods: A retrospective chart review of patients with noninfectious uveitis treated with sustained-release dexamethasone 0.7 mg intravitreal implant was performed. Complete ophthalmic examination including signs of inflammatory activity, visual acuity, fundus photography, fluorescein angiography, optical coherence tomography, and tolerability of the implant were assessed.Results: Six eyes of 4 consecutive patients treated with a total of 8 dexamethasone 0.7 mg sustained-release intravitreal implants for posterior noninfectious uveitis were included. Two patients presented with unilateral idiopathic posterior uveitis; 2 patients had bilateral posterior uveitis, one secondary to sarcoidosis and the other to Vogt-Koyanagi-Harada syndrome. All eyes showed clinical and angiographic evidence of decreased inflammation following implant placement. Mean follow-up time post-injection was 5.25 months. Four eyes received 1 and 2 eyes received 2 Ozurdex implants during the follow-up period. The duration of effect of the implant was 3 to 4 months. No serious ocular or systemic adverse events were noted during the follow-up period.Conclusions: In patients with noninfectious posterior uveitis, sustained-release dexamethasone 0.7 mg intravitreal implant may be an effective treatment option for controlling intraocular inflammation.Keywords: corticosteroids, dexamethasone implant, Ozurdex, uveitis

  20. Primeiro registro de galhas em panículas de cajazeira causadas por Clinodiplosis (Diptera: Cecidomyiidae e avaliação de genótipos no estado do Piauí First record of galls in hog plum (Spondias mombim L. panicles caused by Clinodiplosis (Diptera: Cecidomyiidae and evaluation of genotypes in Piauí State

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    Jaqueline Zanon de Moura

    2010-09-01

    Full Text Available A cajazeira (Spondias mombin L. é uma Anacardiaceae que se destaca pela considerável importância social e econômica no Nordeste brasileiro. Vários autores mencionam insetos que atacam folhas, ramos e frutos de cajazeiras; no entanto, em relação às flores, as informações são limitadas. Cecidomyiidae é uma família bastante diversificada de Nematocera (Diptera. Cecidomyiinae têm hábitos variados e grande riqueza de espécies fitófagas. Neste trabalho, objetivou-se a identificação de uma espécie de Cecidimyiinae galhador em cajazeira, caracterização dos sintomas do ataque e avaliação do nível de infestação em panículas da cajazeira em diferentes genótipos. O experimento foi desenvolvido em pomar de cajazeira do Departamento de Fitotecnia do Centro de Ciências Agrárias da Universidade Federal do Piauí. Foram avaliados oito genótipos: JL 15, LA1, Fazenda Soares I, Fazenda Soares II, Fazenda Soares III, Major, Vagner e Jardim. O inseto foi identificado como Clinodiplosis sp. Considerando-se a alta especificidade de Cecidomyiinae (Clinodiplosini na relação galhador X planta hospedeira, a espécie de Clinodiplosis associada a Spondias mombin provavelmente é nova. Os genótipos Major, LA 1, Soares I e Jardim apresentaram menor infestação. Já os genótipos JL 15, Vagner, Soares III e Soares II apresentaram maior infestação. Pode-se concluir que o nível de infestação das cajazeiras por Clinodiplosis sp. varia de acordo com o genótipo avaliado.Hog plum (Spondias mombim L. is an Anacardiaceae of considerable social and economical importance in Brazilian northeast. Various authors mentioned insects that affect leaves, branches and the fruits, but information related to flower pestsis limited. Cecidomyiidae is a very well diversified family of Nematocera (Diptera. Cecidomyinae has varied habits and a great variety of phytophagaus species. This study had as objective the identification of a galling Cecidomyiinae

  1. Fatores de risco e letalidade de infecção da corrente sanguínea laboratorialmente confirmada, causada por patógenos não contaminantes da pele em recém-nascidos Risk factors and lethality of laboratory-confirmed bloodstream infection caused by non-skin contaminant pathogens in neonates

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    Roberta M.C. Romanelli

    2013-04-01

    Full Text Available OBJETIVO: Avaliar os fatores de risco e a letalidade da infecção da corrente sanguínea laboratorialmente confirmada (ICSLC de início tardio em uma Unidade Neonatal de Cuidados Progressivos (UNCP brasileira. MÉTODOS: Trata-se de um estudo caso-controle realizado de 2008 a 2012. Os casos foram definidos como todos os recém-nascidos com ICSLC de início tardio, excluindo pacientes isolados com contaminantes da pele comuns. Os controles foram recém-nascidos que não mostraram qualquer evidência de ICSLC de início tardio, sendo separados por peso e tempo de permanência na UNCP. As variáveis foram obtidas na base de dados da Comissão de Controle de Infecção Hospitalar (CCIH. A análise foi realizada utilizando o Pacote Estatístico para Ciências Sociais. O teste χ² foi utilizado e a relevância estatística foi definida como p OBJECTIVE: To evaluate risk factors and lethality of late onset laboratory-confirmed bloodstream infection (ICSLC in a Brazilian neonatal unit for progressive care (NUPC. Methods: This was a case-control study, performed from 2008 to 2012. Cases were defined as all newborns with late onset ICSLC, excluding patients with isolated common skin contaminants. Controls were newborns who showed no evidence of late onset ICSLC, matched by weight and time of permanence in the NUPC. Variables were obtained in the Hospital Infection Control Committee (HICC database. Analysis was performed using the Statistical Package for the Social Sciences (SPSS. The chi-squared test was used, and statistical significance was defined as p < 0.05, followed by multivariate analysis. RESULTS: 50 patients with late onset ICSLC were matched with 100 patients without late onset ICSLC. In the group of patients with late onset ICSLC, a a significant higher proportion of patients who underwent surgical procedures (p = 0.001 and who used central venous catheter (CVC (p = 0.012 and mechanical ventilation (p = 0.001 was identified. In multivariate

  2. Relationships of systemic IgG antibody response and lesions caused by Oestrus ovis L. larvae (Diptera: Oestridae in infected goats - Interacciones de la respuesta sistémica de anticuerpos IgG y las lesiones causadas por larvas de Oestrus ovis L. (Diptera: Oestridae en cabras infectadas

    Directory of Open Access Journals (Sweden)

    Angulo-Valadez, Carlos E

    2009-11-01

    la glándula salival para elserodiagnóstico de la estrosis caprina usando la prueba de ELISA. Secapturaron larvas de tercer estadio (L3, se disectaron para removerla glándula salival y obtener la fuente de antígenos (CGS. Seexaminaron en necropsias 250 cabras. El peso, sexo y edad fueronregistrados. Los senos frontales y cavidades cornuales se examinaronpara la presencia de O. ovis. La intensidad de las lesiones en cabrasinfectadas (n=38 se registraron de acuerdo con una tabla deseveridad. Los sueros (n=125 se analizaron por ELISA para detectarla respuesta humoral de IgG. La prevalencia anual de la estrosiscaprina fue 73.9%. Una asociación baja positiva (r=0.38, P<0.05 seobservó entre la carga larvaria y la severidad de las lesionesencontradas. En general, se observaron alta sensibilidad (90.82% ybaja especificidad (25.93% en la prueba de ELISA. Comoconclusiones, los daños patológicos mayores se asociaron al númeroy presencia de larvas tempranas L2 y L3, probablemente inducidospor la muda larvaria. Los antígenos CGS demostraron ser valiosos enla prueba de ELISA para el diagnóstico de la estrosis caprina.

  3. The clinical course of juvenile idiopathic arthritis-associated uveitis in childhood and puberty

    NARCIS (Netherlands)

    Hoeve, Maretta; Ayuso, Viera Kalinina; Schalij-Delfos, Nicoline E.; Los, Leonoor I.; Rothova, Aniki; de Boer, Joke H.

    2012-01-01

    Aim The long-term course of juvenile idiopathic arthritis (JIA)-associated uveitis is not known yet. This study investigates the course and activity of JIA-associated uveitis in childhood and puberty. Design Retrospective study of the clinical data of 62 JIA patients with uveitis. The main outcome m

  4. Micetoma por Nocardia brasiliensis: reporte de caso

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    Miriam Guevara R

    2003-07-01

    Full Text Available Se presenta el caso de un paciente peruano, agricultor, con una infección cutánea de origen traumático causada por Nocardia brasiliensis, que evolucionó hacia la amputación del miembro inferior afectado. El diagnóstico se realizó por examen directo y cultivo del espécimen.

  5. Birdshot uveitis: current and emerging treatment options

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    Menezo V

    2013-12-01

    Full Text Available Victor Menezo,1,2 Simon RJ Taylor3,4 1Institut Catala de Retina, Barcelona, Spain; 2Department of Ophthalmology, Provincial Hospital Consortium Castellon, Castello, Spain; 3Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK; 4Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK Abstract: Birdshot chorioretinopathy is a relatively uncommon subtype of idiopathic posterior uveitis with distinct clinical characteristics and a strong genetic association with the Human Leukocyte Antigen (HLA-A29 allele. The diagnosis remains clinical and is based on the presence of typical clinical features, including multiple, distinctive, hypopigmented choroidal lesions throughout the fundus. The long-term visual prognosis of this disorder, however, remains guarded – central visual acuity can be preserved until late in the disease and it is not uncommon for patients to receive inadequate immunosuppressive treatment, leading to a poor long-term outcome in which peripheral retinal damage eventually leads to visual deterioration. Birdshot chorioretinopathy has proven a particularly attractive area of study within the field of uveitis, as it is a relatively easily defined disease with an associated human leukocyte antigen haplotype. Despite this, however, the immune mechanisms involved in its pathogenesis remain unclear, and some patients continue to lose retinal function despite therapy with corticosteroids and conventional immunosuppressive agents. Laboratory research continues to investigate the underlying mechanisms of disease, and clinical research is now being driven to improve the phenotyping and monitoring of this condition as, in the era of so-called personalized medicine, it is becoming increasingly important to identify patients at risk of visual loss early so that they can be treated more aggressively with targeted therapies such as the newer biological agents. This approach requires the formation of collaborative

  6. Uveitis in autoimmune hepatitis: A case report

    Institute of Scientific and Technical Information of China (English)

    Roberto Giulio Romanelli; Giorgio La Villa; Fabio Almerigogna; Francesco Vizzutti; Elena Di Pietro; Valentina Fedi; Paolo Gentilini; Giacomo Laffi

    2006-01-01

    In this case report we describe for the first time an association between autoimmune hepatitis (AIH)and uveitis, without any doubts about other possible etiologies, such as HCV, since all the old reports describe the association of AIH with iridocyclitis before tests for HCV-related hepatitis could be available. A 38-year-old businessman with abnormal liver function tests and hyperemia of the bulbar conjunctiva was admitted to the hospital. Six years before admission,the patient presented with persistent fever, arthralgias,conjunctival hyperemia, leukocytosis and increased ESR, referred to acute rheumatic fever. The presence of systemic diseases, most commonly associated with uveitis, was investigated without results and the patient was then treated with topical corticosteroids. His symptoms resolved. A test for anti-nuclear antibodies was positive, at a titre of 1:320, with a speckled and nucleolar staining pattern. Liver ultrasound showed mild hepatomegaly with an increased echostructure of the liver. Percutaneous liver biopsy was performed under ultrasound assistance. Histological examination showed necroinflammation over the portal, periportal and lobular areas, fibrotic portal tracts, with periportal fibrosis and occasional portal-to-portal bridgings, but intact hepatic architecture. Some hepatocytes showed barely discernible granules of hemosiderin in the lobular area. Bile ductules had not any significant morphological alterations. METAVIR score was A2-F3, according to the modified HAI grading/fibrosis staging. The patient was diagnosed to have AIH with mild activity and fibrosis and was discharged on 25 mg prednisone, entering clinical and biochemical remission, further confirming diagnosis. After discharge the patient continued to have treatment with corticosteroids as an outpatient at a dose of 5 mg. On January 2002 the patient was readmitted to the hospital. A test for anti-nuclear antibodies was positive, at a titre of 1:320, with a speckled and

  7. Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer

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    El Saghir Nagi S

    2005-12-01

    Full Text Available Abstract Background Zoledronic acid is very widely used in patients with metastatic bone disease and osteoporosis. Only one case of bilateral uveitis was recently reported related to its use. Case presentation We report the first case of severe unilateral anterior uveitis in a patient with breast cancer and an intraocular lens. Following zoledronic acid infusion, the patient developed severe and dramatic right eye pain with decreased visual acuity within 24 hours and was found to have a fibrinous anterior uveitis of moderate severity The patient was treated with topical prednisone and atropine eyedrops and recovered slowly over several months. Conclusion Internists, oncologists, endocrinologists, and ophtalmologists should be aware of uveitis as a possible complication of zoledronic acid therapy. Patients should be instructed to report immediately to their physicians and treatment with topical prednisone and atropine eyedrops should be instituted immediately at the onset of symptoms. This report documents anterior uveitis as a complication of zoledronic acid therapy. This reaction could be an idiosyncratic one but further research may shed more light on the etiology.

  8. Diagnosis and treatment of anterior uveitis: optometric management

    Directory of Open Access Journals (Sweden)

    Harthan JS

    2016-03-01

    Full Text Available Jennifer S Harthan,1 Dominick L Opitz,2 Stephanie R Fromstein,1 Christina E Morettin3 1Cornea Center for Clinical Experience, 2Ophthalmology Services and Practice Development, 3Urgent Eye Care Service, Illinois College of Optometry, Chicago, IL, USA Abstract: Anterior uveitis encompasses inflammation of the iris and/or ciliary body and is one of the most common types of ocular inflammation that primary eye care practitioners will encounter. Anterior uveitis may be caused by a variety of etiologies, including infectious, noninfectious, and masquerade diseases. The short-term and long-term treatment of uveitis should include the evaluation of location, duration, pathology, and laterality, in addition to presenting signs and symptoms of the disease. A complete review of systems, thorough examination, and laboratory testing, may assist the practitioner in narrowing the list of possible causes for the uveitis. This is imperative as once a list of diagnoses has been made, a targeted approach to treatment can be pursued. Keywords: anterior uveitis, iritis, inflammation

  9. Immunomodulation in human and experimental uveitis: Recent advances

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    Singh Vijay

    1999-01-01

    Full Text Available Experimental autoimmune uveitis (EAU is a T-cell mediated autoimmune disease that targets the neural retina and serves as a model of human uveitis. EAU can be induced against several retinal proteins in rats, mice, and subhuman primates. These include the S-antigen, a major protein in retinal photoreceptor cells; interphotoreceptor retinoid-binding protein (IRBP; and rhodopsin and other antigens of retinal origin. There are many similarities between clinical uveitis and EAU, but the latter differs in being self-limited, and needs adjuvant for disease induction. The experimental disease can be induced only in susceptible animal strains. Use of the EAU model has helped investigators understand the pathophysiology of the disease and to evaluate disease-modifying strategies, which could be applied in the clinic. There has been significant progress in this field during last decade, but much more understanding is needed before the knowledge can be transferred to clinical practice. A deeper understanding of the immune mechanisms involved in the EAU model may lead to the development of new therapeutic approaches targeted at various components of the immune response by immunomodulation to control uveitis. This review summarises the evidence from the EAU model, which could be of relevance to the clinical management of patients with uveitis.

  10. Intraocular Implants for the Treatment of Autoimmune Uveitis

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    Darren J. Lee

    2015-07-01

    Full Text Available Uveitis is the third leading cause of blindness in developed countries. Currently, the most widely used treatment of non-infectious uveitis is corticosteroids. Posterior uveitis and macular edema can be treated with intraocular injection of corticosteroids, however, this is problematic in chronic cases because of the need for repeat injections. Another option is systemic immunosuppressive therapies that have their own undesirable side effects. These systemic therapies result in a widespread suppression of the entire immune system, leaving the patient susceptible to infection. Therefore, an effective localized treatment option is preferred. With the recent advances in bioengineering, biodegradable polymers that allow for a slow sustained-release of a medication. These advances have culminated in drug delivery implants that are food and drug administration (FDA approved for the treatment of non-infectious uveitis. In this review, we discuss the types of ocular implants available and some of the polymers used, implants used for the treatment of non-infectious uveitis, and bioengineered alternatives that are on the horizon.

  11. Gender and Uveitis in Patients with Multiple Sclerosis

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    Lynn K. Gordon

    2014-01-01

    Full Text Available Multiple sclerosis (MS, a demyelinating disease of the central nervous system, is more commonly seen in women. It has been associated with both anterior and intermediate uveitis as well as retinal vasculitis. Ocular inflammation may develop concurrent with, prior to, or after the development of neurologic signs and symptoms. Patients with MS have an approximately 1% chance of developing intraocular inflammation. Patients with intermediate uveitis have an 8–12% risk of being diagnosed with MS. This risk is higher in females and in those with bilateral disease. This should be kept in mind when evaluating patients with uveitis, particularly in those patients for whom TNF inhibitor therapy is being considered, as these agents may worsen demyelinating disease.

  12. Anterior Uveitis as an Initial Manifestation of Polymyalgia Rheumatica

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    Hiromasa Tsuda

    2011-01-01

    Full Text Available A 74-year-old woman without contributory medical history presented with acute iridocyclitis in the right eye. Although the iridocyclitis disappeared within two weeks under topical steroid, she complained of acute progressing bilateral shoulder pain and morning stiffness of upper extremities. She was diagnosed as having polymyalgia rheumatica (PMR, and iridocyclitis was considered as its related manifestation. PMR and giant cell arteritis (GCA are closely related conditions and frequently occur together. GCA with uveitis has been rarely noted. However, ocular symptoms in PMR have not been previously mentioned. This is a first reported case of PMR presented with uveitis, without a complication of GCA. This anterior uveitis might be caused by ischemia of the posterior ciliary arteries and their branches.

  13. Phacoemulsification in Patients with Secondary Glaucoma Caused by Uveitis

    Institute of Scientific and Technical Information of China (English)

    Mingkai Lin; Jian Ge; Yizhi Liu; Yuqing Lan; Yehong Zhou

    2001-01-01

    Purposes: To evaluate the effect of phacoemulsification in the patients with uveitis,secondary glaucoma and complicated cataract. Methods: Phacoemulsification and implantation of a foldable intraocular len was performed in 12 patients(13 eyes) with uveitis, secondary glaucoma and complicated cataract. The complications, intraocular pressures (IOP), and visual acuity were observed postoperatively. Results: No severe complication was found in the patients postoperatively or within the operation procedure. The visual acuity was improved after the operation ( P < 0.05) .The intraocular pressures and/or the number of antiglaucoma medications reduced in 3months of the follow-up time. Conclusion: phacoemulsification is the best way to treat the patients with secondary glaucoma and complicated cataract caused by uveitis. Eye Science 2001; 17: 8 ~ 10.

  14. Management of noninfectious posterior uveitis with intravitreal drug therapy

    Science.gov (United States)

    Tan, Hui Yi; Agarwal, Aniruddha; Lee, Cecilia S; Chhablani, Jay; Gupta, Vishali; Khatri, Manoj; Nirmal, Jayabalan; Pavesio, Carlos; Agrawal, Rupesh

    2016-01-01

    Uveitis is an important cause of vision loss worldwide due to its sight-threatening complications, especially cystoid macular edema, as well as choroidal neovascularization, macular ischemia, cataract, and glaucoma. Systemic corticosteroids are the mainstay of therapy for noninfectious posterior uveitis; however, various systemic side effects can occur. Intravitreal medication achieves a therapeutic level in the vitreous while minimizing systemic complications and is thus used as an exciting alternative. Corticosteroids, antivascular endothelial growth factors, immunomodulators such as methotrexate and sirolimus, and nonsteroidal anti-inflammatory drugs are currently available for intravitreal therapy. This article reviews the existing literature for efficacy and safety of these various options for intravitreal drug therapy for the management of noninfectious uveitis (mainly intermediate, posterior, and panuveitis).

  15. Bilateral sacroiliitis and uveitis comorbidity: brucellosis? Ankylosing spondylitis?

    Science.gov (United States)

    Akyol, Lütfi; Aslan, Kerim; Özgen, Metin; Sayarlioglu, Mehmet

    2015-09-22

    We present a rare case of a comorbidity of sacroiliitis and brucellosis infection. A 28-year-old woman received irregular medication due to ongoing backache and hip pain for 5 years. The patient presented to our hospital for evaluation of visual loss and was diagnosed with uveitis. Sacroiliac MRI was performed to investigate the inflammatory backache and hip pain, and the aetiology of the uveitis, revealing the presence of sacroiliitis. The patient's blood test results were as follows: positive brucellosis Rose Bengal test and positive tube agglutination test with a titre of 1/640. The patient was treated with doxycycline and rifampicin for 8 weeks for the brucellosis infection, and with acemetacin for the ankylosing spondylitis. The patient's back and hip pain decreased significantly 8 weeks later; however, the uveitis was not controlled by the treatment. Therefore, anti-tumour necrosis factor (infliximab) treatment was started.

  16. Uveitis as first manifestation of probably Crohn's disease Uveíte como primeira manifestação de provável doença de Crohn

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    Ieda Maria Alexandre Barreira

    2012-12-01

    Full Text Available Extraintestinal manifestations of Crohn's disease are common. Although ocular complications of Crohn's disease are infrequent, most ocular manifestations include iritis, uveitis, episcleritis, scleritis and conjuntivitis. We report a patient who developed uveitis two years before diagnose of Crohn's disease.Manifestações extraintestinais da doença de Crohn são comuns. As manifestações oculares são infrequentes e caracterizam-se em sua maioria por irite, uveíte, episclerite, esclerite e conjuntivite. Relatamos o caso de uma paciente que desenvolveu uveíte dois anos antes de firmado o diagnóstico de doenca de Crohn.

  17. Comportamiento de la diarrea causada por virus y bacterias en regiones cercanas a la zona ecuatorial

    OpenAIRE

    María Fernanda Gutiérrez; Delfina Urbina; Adriana Matiz; Martha Puello; Marcela Mercado; Miguel Parra; Nadim Ajami; Piedad Serrano; Alba Alicia Trespalacios

    2005-01-01

    INTRODUCCIÓN: La enfermedad diarreica aguda (EDA) es un problema de salud a nivel mundial que afecta a la población infantil de distintas regiones. Casi todos los estudios epidemiológicos se han hecho en países con estaciones y poco se informa su comportamiento en países sin estaciones, donde la EDA es endémica con picos epidémicos. OBJETIVOS: Contribuir a conocer la conducta de EDA en Colombia y determinar si su comportamiento es diferente en niños menores de cinco años en dos regiones disti...

  18. Caída de la flor en kiwi causada por bacterias fitopatógenas

    OpenAIRE

    González, A.J.

    2010-01-01

    La cáida de flor en kiwi causa pérdidas importantes de producción cuando las condiciones climatológicas son favorables al desarrollo de las bacterias. En Asturias se han descrito dos especies bacterianas, "Pseudomonas viridiflava" y "P. syringae", como agentes causales de este problema

  19. Cerebelite aguda causada por vírus Epstein-Barr: relato de caso

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    Teive Hélio A.G.

    2001-01-01

    Full Text Available A cerebelite aguda pode ocorrer em associação a infecção pelo vírus da varicela-zoster, enterovirus, caxumba, micoplasma e outros agentes infecciosos. A cerebelite aguda é uma complicação rara da infecção pelo vírus Epstein-Barr (EBV. Relatamos o caso de uma mulher de 21 anos com história de 12 dias de evolução com náuseas, vômitos, ataxia de marcha e membros, tremor cefálico e de membros, opsoclono, mioclonias e rash cutâneo. Sorologia para EBV foi positiva. A infecção pelo EBV, com complicações neurológicas, pode não se apresentar com os sinais e sintomas clássicos da mononucleose infeciosa.

  20. Enoftalmia causada por uso tópico unilateral de Bimatoprost

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    Guilherme Herzog Neto

    2016-02-01

    Full Text Available RESUMO O autor descreve o caso de uma paciente que apresenta o olho direito com o sulco palpebral profundo e enoftalmia deste lado, tratado durante uma década com Bimatoprost tópica. Concluem que os achados clínicos são provavelmente efeitos colaterais do medicamento.

  1. SENSIBILIDAD ANTIMICROBIANA CAUSADA POR EL Streptococcus Pyogenes EN MUESTRAS DE CULTIVO DE EXUDADO FARÍNGEO

    OpenAIRE

    Solórzano Solórzano, Stalin Lorenzo; Universidad Técnica de Machala, El Oro – Ecuador

    2016-01-01

    El Streptococcus pyogenes es uno de los de los gérmenes patógenos más frecuentes, causante de enfermedades supurativas y no supurativas; son la causa más habitual de faringitis bacteriana y constituye una de las mayores causas de enfermedad infecciosa relacionada con morbi-mortalidad en todo el mundo. Después de un período de incubación de 2 a 4 días; el aislamiento del microorganismo causal en el exudado faríngeo no implica necesariamente su patogenicidad; y  es necesaria la demostración de ...

  2. Characterization of amyloid in equine recurrent uveitis as AA amyloid.

    Science.gov (United States)

    Ostevik, L; de Souza, G A; Wien, T N; Gunnes, G; Sørby, R

    2014-01-01

    Two horses with chronic uveitis and histological lesions consistent with equine recurrent uveitis (ERU) were examined. Microscopical findings in the ciliary body included deposits of amyloid lining the non-pigmented epithelium, intracytoplasmic, rod-shaped, eosinophilic inclusions and intraepithelial infiltration of T lymphocytes. Ultrastructural examination of the ciliary body of one horse confirmed the presence of abundant extracellular deposits of non-branching fibrils (9-11 nm in diameter) consistent with amyloid. Immunohistochemistry revealed strong positive labelling for AA amyloid and mass spectrometry showed the amyloid to consist primarily of serum amyloid A1 in both cases. The findings suggest that localized, intraocular AA amyloidosis may occur in horses with ERU.

  3. Macular edema in uveitis with emphasis on ocular sarcoidosis

    NARCIS (Netherlands)

    Norel, J. van

    2015-01-01

    This thesis investigates the accumulation of fluid in the yellow spot (macular edema) in ocular inflammation (uveitis). Macular edema may result in definitive loss of vision.Two methods of imaging of macular edema are fluorescein angiography (FA) and optical coherence tomography (OCT). The first met

  4. Prevalence and clinical impact of antiretinal antibodies in uveitis

    NARCIS (Netherlands)

    J.C.E.M. Ten Berge (Josianne C.E.M.); M.W. Schreurs (Marco W.); J. Vermeer (Jacolien); M.A. Meester-Smoor (Magda); A. Rothova (Aniki)

    2016-01-01

    textabstractPurpose: To determine the prevalence of serum antiretinal antibodies (ARAs) among patients with uveitis and establish their clinical relevance. Methods: This prospective study assessed the presence of ARAs by indirect immunofluorescence (IIF) using primate retina in 126 patients with uve

  5. Association between intermediate uveitis and toxocariasis in the Korean population.

    Science.gov (United States)

    Kwon, Jin-Woo; Sim, Yoonseob; Jee, Donghyun

    2017-02-01

    The aim of the study was to investigate the characteristics of ocular toxocariasis (OT) presenting with intermediate uveitis in the Korean population.We studied intermediate uveitis patients using ocular and systemic evaluations and a Toxocara IgG serology test.Of 50 intermediate uveitis patients, 19 were seropositive for Toxocara IgG. Of the 19 OT patients, 4 presented with recurrence within 6 months and were significantly younger than nonrecurrence patients (P = 0.009). Thirteen patients had a history of eating raw cow liver.There were 14 males and 5 females in the OT group, and 11 males and 20 females in the non-OT group (P = 0.009). There was bilateral involvement in 7 out of 19 patients in the OT group, and 20 out of 31 patients in non-OT group (P = 0.033).Intermediate uveitis patients in OT were predominately male and had more unilateral presentation than non-OT patients.

  6. Patterns of uveitis in children presenting at a tertiary eye care centre in south India

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    Narayana Kannan

    2003-01-01

    Full Text Available Purpose: To study the patterns of uveitis in the paediatric age group in a referral eye care centre in south India. Materials and Methods: Thirty-one patients 15 years or younger with uveitis, examined in the year 2000, were included in this study. The uveitis was classified according to the anatomical site of ocular involvement and the most probable aetiological factor. The final diagnosis was based on clinical manifestations and results of specific laboratory investigations. Results: A total 31 (6.29% paediatric uveitis cases were seen among the 493 uveitic cases in the year 2000. The male: female ratio was 17:14. Anterior (9 cases, intermediate (9 cases and posterior uveitis (9 cases were seen in equal number. Four patients had panuveitis. Twenty-seven patients had visual acuity of 6/36 or better at presentation. Approximately 25% (8 of 31 patients had cataract secondary to inflammation. Immunosuppressives were administered in 4 patients and one patient required cataract surgery. Conclusion: Uveitis in children comprises approximately 6% of uveitis cases in a referral practice in south India. Anterior, intermediate and posterior uveitis are seen in equal numbers. We recommend that intermediate uveitis be ruled out in all cases of anterior uveitis by careful clinical evaluation including examination under anesthesia (EUA when required.

  7. Toxicidade ocular causada pela cloroquina: relato de caso Ocular toxicity caused by chloroquine: case report

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    Eliane Terumi Inada

    2005-06-01

    Full Text Available Relatar um caso de toxicidade ocular causada pela cloroquina. Aferiu-se a acuidade visual de ambos os olhos em tabela de Snellen. Foram realizados biomicroscopia do segmento anterior, refração, oftalmoscopia, angiofluoresceinografia e retinografia numa paciente de 53 anos, sexo feminino, portadora de artrite reumatóide. Fez uso de cloroquina por 6 anos e havia parado há um ano, quando veio ao nosso serviço. Apresentava acuidade visual corrigida de 20/200 e 20/40. À biomicroscopia do segmento anterior apresentava lente intra-ocular no olho direito e catarata nuclear 1+/4+ no olho esquerdo, com opacidade corneana subepitelial inferior ao eixo visual em ambos os olhos. À oftalmoscopia, apresentava mácula com aspecto de tacho batido (atrofia do epitélio pigmentar da retina. A angiofluoresceinografia mostrou maculopatia com aspecto de olho de boi. Relata-se um caso típico de ceratopatia e maculopatia causados pela cloroquina.To report a case of ocular toxicity due to chloroquine. The best visual acuity was measured in both eyes with the Snellen chart. Slit-lamp examination of anterior segment, refraction, dilated fundus examination, fluorescein angiography and retinography was done in a 53-year-old patient, female, with rheumatoid arthritis. She had used chloroquine during 6 years and had stopped for 1 year when she came to our service. She had best corrected visual acuity of 20/200 and 20/40. Slit-lamp examination showed intraocular lens in right eye and nuclear cataract (1+/4 in the other, and bilateral corneal subepithelial opacity inferior to the visual axis. Fundus examination showed macular area with retinal pigment epithelium atrophy. Fluorescein angiography showed a bull's eye maculopathy. Report of a typical keratopathy and maculopathy caused by chloroquine.

  8. Management of noninfectious posterior uveitis with intravitreal drug therapy

    Directory of Open Access Journals (Sweden)

    Tan HY

    2016-10-01

    Full Text Available Hui Yi Tan,1 Aniruddha Agarwal,2 Cecilia S Lee,3 Jay Chhablani,4 Vishali Gupta,5 Manoj Khatri,6 Jayabalan Nirmal,7 Carlos Pavesio,8 Rupesh Agrawal1,7–9 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 2Department of Vitreoretina, Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, 3Department of Ophthalmology, University of Washington, Seattle, WA, USA; 4Department of Vitreoretina, L V Prasad Eye Institute, Hyderabad, Telangana, 5Department of Retina and Uvea, Post Graduate Institute of Medical Education and Research, Chandigarh, 6Department of Retina, Rajan Eye Care Hospital, Chennai, Tamil Nadu, India; 7School of Material Science and Engineering, Nanyang Technological University, Singapore; 8Department of Medical Retina, Moorfields Eye Hospital, NHS Foundation Trust, London, UK; 9Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore Abstract: Uveitis is an important cause of vision loss worldwide due to its sight-threatening complications, especially cystoid macular edema, as well as choroidal neovascularization, macular ischemia, cataract, and glaucoma. Systemic corticosteroids are the mainstay of therapy for noninfectious posterior uveitis; however, various systemic side effects can occur. Intravitreal medication achieves a therapeutic level in the vitreous while minimizing systemic complications and is thus used as an exciting alternative. Corticosteroids, antivascular endothelial growth factors, immunomodulators such as methotrexate and sirolimus, and nonsteroidal anti-inflammatory drugs are currently available for intravitreal therapy. This article reviews the existing literature for efficacy and safety of these various options for intravitreal drug therapy for the management of noninfectious uveitis (mainly intermediate, posterior, and panuveitis. Keywords: intravitreal therapy, noninfectious uveitis, posterior uveitis

  9. A case of recurrent bilateral uveitis independently associated with dabrafenib and pembrolizumab therapy

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    Stanford C. Taylor

    2016-07-01

    Conclusions and importance: Dabrafenib and pembrolizumab therapy have both previously been associated with uveitis. Here, we document a case of a woman who developed acute uveitis in response to beginning therapy with dabrafenib and then later developed acute uveitis soon after initiating pembrolizumab. To our knowledge, this is the first time this uncommon side-effect has been reported in the same patient after receiving sequential targeted agents and checkpoint inhibitors.

  10. A new era of uveitis: impact of polymerase chain reaction in intraocular inflammatory diseases.

    Science.gov (United States)

    Mochizuki, Manabu; Sugita, Sunao; Kamoi, Koju; Takase, Hiroshi

    2017-01-01

    Uveitis is a sight-threatening intraocular inflammatory disorder which may occur from both infectious and non-infectious or autoimmune causes. The frequency of infectious uveitis and autoimmune uveitis varies depending on countries and regions. According to a nationwide survey conducted by the Japanese Ocular Inflammation Society, infectious and non-infectious uveitis accounted for 16.4 and 50.1% of new patients, respectively while the remaining 33.5% of new uveitis cases were not classified or were idiopathic uveitis. Infectious uveitis is particularly important because it causes tissue damage to the eye and may result in blindness unless treated. However, it can be treated if the pathogenic microorganisms are identified promptly and accurately. Remarkable advancements in molecular and immunological technologies have been made in the last decade, and the diagnosis of infectious uveitis has been greatly improved by the application of molecular and immunological investigations, particularly polymerase chain reaction (PCR). PCR performed on a small amount of ocular samples provides a prompt, sensitive, and specific molecular diagnosis of pathogenic microorganisms in the eye. This technology has opened a new era in the diagnosis and treatment of uveitis, enabling physicians to establish new clinical entities of uveitis caused by infectious microorganisms, identify pathogens in the eyes of many patients with uveitis, and determine prompt diagnosis and appropriate therapy. Here we review the PCR process, new PCR tests specialized for ocular diseases, microorganisms detected by the PCR tests, diseases in the eye caused by these microorganisms, and the clinical characteristics, diagnosis, and therapy of uveitis.

  11. Patterns of Uveitis at a Tertiary Referral Center in Southern Iran

    OpenAIRE

    Mansour Rahimi; Ghazaleh Mirmansouri

    2014-01-01

    Purpose: To ascertain the patterns of uveitis at Motahari uveitis clinic, Shiraz University of Medical Sciences, a tertiary referral center in Shiraz, Southern Iran. Methods: All new cases of uveitis referred from June 2005 to July 2011 to our center were consecutively enrolled in the study. After taking a complete history of systemic and ocular diseases, all patients underwent a complete ophthalmologic examination including determination of Snellen visual acuity, slit lamp biomicroscopy,...

  12. A case with chronic hepatitis B and anterior uveitis - Is there any connection?

    OpenAIRE

    Köse, Şükran; Senger, Süheyla Serin; Çavdar, Gülsün; Ersan, Gürsel

    2015-01-01

    Acute anterior uveitis is an intraocular inflammation and the responsible factors of its pathogenesis are mostly unknown. Some viruses such as HSV, CMV and VZV may be implicated in the etiology. Noninfectious uveitis is thought to be autoimmune. Chronic hepatitis B virus (HBV) infection may cause multiple complications, which are thought to be immune system mediated. Recently, some studies suggested that HBV could be one of the triggers for uveitis. In this paper we present an anterior uve...

  13. Rubella Virus-associated Anterior Uveitis in a Vaccinated Patient: A Case Report.

    Science.gov (United States)

    ten Berge, Josianne C E M; van Daele, Paul L A; Rothova, Aniki

    2016-01-01

    Rubella virus is involved in the pathogenesis of Fuchs heterochromic uveitis and almost all cases in Europe show an active antibody production in the aqueous humor against rubella virus. Herein we report a case of a fully vaccinated patient with common variable immunodeficiency who developed unilateral Fuchs heterochromic uveitis secondary to rubella virus which was proven by intraocular fluid examination. Awareness of rubella associated anterior uveitis should remain also in vaccinated patients, especially those without a fully competent immune system.

  14. A Review of the Course and Treatment of Non-Infectious Uveitis during Pregnancy.

    Science.gov (United States)

    Grotting, Lindsay A; Papaliodis, George N

    2017-01-01

    Inflammatory conditions such as autoimmune uveitis often occur in women of childbearing age. During pregnancy, women may experience exacerbations of their disease in the first trimester. In the later stages of pregnancy, however, the uveitis tends to remain less active. The management of uveitis during pregnancy is a challenging task, forcing the physician to re-evaluate the patient's current therapy and offer alternative options that pose the least risk to the patient and fetus. This article will review treatments widely used for uveitis, including corticosteroid therapy, anti-metabolites, calcineurin inhibitors, and biologic therapy. It will evaluate the use of these medications in pregnancy and the postpartum state.

  15. Enfermedad mixta del tejido conectivo como causa de fiebre de origen por determinar.

    OpenAIRE

    Trejo Ayala, Rafael; Montúfar, Rubén

    2013-01-01

    La Fiebre de Origen por Determinar,constituye un verdadero reto para el médico,ya que puede ser causada y desarrollada por múltiples causas entre las que se pueden mencionar: las enfermedades infecciosas, neopáticas, colágeno vascular, misceláneas e idiopáticas.

  16. The Ocular Immunology and Uveitis Foundation preferred practice patterns of uveitis management.

    Science.gov (United States)

    Foster, C Stephen; Kothari, Srishti; Anesi, Stephen D; Vitale, Albert T; Chu, David; Metzinger, Jamie Lynne; Cerón, Olga

    2016-01-01

    Ocular inflammatory disease is a leading cause of vision loss worldwide. Uveitis encompasses a wide spectrum of pathology, both with respect to its etiology and the anatomic location within the eye. Inflammation can be confined to the eye and may also be seen systemically. The cornerstone of management of ocular inflammatory disease historically has been corticosteroids, which are invaluable in the immediate control of inflammation; however, corticosteroids are inappropriate for long-term use as they are associated with a wide array of toxic side effects. As we continue to learn more about the various etiologies and elucidate the basic science pathways and mechanisms of action that cause intraocular inflammation, new therapeutic approaches have evolved. They include employment of immunomodulatory agents (corticosteroid-sparing therapies) that have expanded our treatment options for these vision-threatening diseases. These pharmacologics provide therapy for ocular and systemic inflammation in an individualized, patient-tailored, stepladder approach with the ultimate goal of durable, corticosteroid-free remission. We review the preferred practice patterns of a tertiary care center specializing in ocular inflammatory disease.

  17. Relapsing acute myeloid leukemia presenting as hypopyon uveitis

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    Sapna P Hegde

    2011-01-01

    Full Text Available Anterior segment infiltration in acute myeloid leukemia (AML presenting as hypopyon uveitis is very rare. We report this case as an uncommon presentation in a patient on remission after bone marrow transplant for AML. In addition to the hypopyon, the patient presented with "red eye" caused by ocular surface disease due to concurrent graft-versus-host disease and glaucoma. The classical manifestations of masquerade syndrome due to AML were altered by concurrent pathologies. Media opacities further confounded the differential diagnosis. We highlight the investigations used to arrive at a definitive diagnosis. In uveitis, there is a need to maintain a high index of clinical suspicion, as early diagnosis in ocular malignancy can save sight and life.

  18. Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis

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    Roesel M

    2011-09-01

    Full Text Available Martin Roesel1, Christoph Tappeiner2, Arnd Heiligenhaus1,3, Carsten Heinz1,31Department of Ophthalmology, St Franziskus-Hospital, Muenster, Germany; 2Department of Ophthalmology, Inselspital, University of Bern, Switzerland; 3University Duisburg-Essen, GermanyAbstract: Voclosporin, a novel immunomodulatory drug inhibiting the calcineurin enzyme, was developed to prevent organ graft rejection and to treat autoimmune diseases. The chemical structure of voclosporin is similar to that of cyclosporine A, with a difference in one amino acid, leading to superior calcineurin inhibition and less variability in plasma concentration. Compared with placebo, voclosporin may significantly reduce inflammation and prevent recurrences of inflammation in patients with noninfectious uveitis. Future studies have to show if these advantages are accompanied by greater clinical efficacy and fewer side effects compared with the classic calcineurin inhibitors.Keywords: uveitis, immunosuppression, voclosporin

  19. Granulomatous uveitis in Crohn's disease. A clinicopathologic case report.

    Science.gov (United States)

    Salmon, J F; Wright, J P; Bowen, R M; Murray, A D

    1989-05-01

    Recurrent episodes of uveitis occurred in a young male patient with clinical as well as radiologic and histologic evidence of Crohn's ileocolitis. His left eye became blind and painful, and was enucleated. Histopathologic examination of the eye revealed a panuveitis with evidence of granuloma formation in the choroid. While granulomatous inflammation has previously been demonstrated in extraintestinal sites, to our knowledge, this is the first histopathologic evidence of granuloma formation within the eye in Crohn's disease.

  20. Peripheral Vasculitis, Intermediate Uveitis and Interferon Use in Multiple Sclerosis

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    Haluk Esgin

    2016-01-01

    Full Text Available Multiple sclerosis (MS is a chronic inflammatory demyelinating disease of the central nervous system. A 40-year-old female patient with a 12-year history of MS was admitted to our clinic with blurred vision and floaters in her right eye for about 1 month. Here, we share the findings and the management of intermediate uveitis and retinal periphlebitis in an MS case being treated with interferon beta-1a for 7 years.

  1. A Rare Manifestation of Uveitis-glaucoma-hyphema Syndrome

    Science.gov (United States)

    Leal, Inês; Faria, Mun Yueh; Pinto, Luís Abegão

    2016-01-01

    ABSTRACT Aims: To report a case of a patient who developed uveitis-glaucoma-hyphema (UGH) syndrome after an uneventful cataract surgery and to discuss risk factors, diagnostic challenges, management options, and clinical implications. Background: Uveitis-glaucoma-hyphema syndrome is a rare but potentially serious cataract surgery complication. Clinical manifestations include increased intraocular pressure (IOP), anterior chamber inflammation, and recurrent hyphema or microhyphema. Uveitis-glaucoma-hyphema Plus syndrome also includes accompanying vitreous hemorrhage. Although classically associated with rigid anterior chamber intraocular lenses (lOLs), cases of malpositioning and subluxated posterior chamber lOLs have also been described as possible triggers. Case description: We report a case of a 70-year-old Caucasian man who developed UGH Plus syndrome after an uneventful cataract surgery with an lOL implanted in the capsular bag. During postoperative follow-up, persistent intraocular inflammation, increased IOP, hyphema, and vitreous hemorrhage were consistent with this diagnosis. Slit-lamp examination demonstrated progressive localized iris atrophy, compatible with chafing of the posterior iris by the IOL haptic as the trigger for UGH syndrome. A pars plana vitrectomy was performed and a retropupillary intraocular lens was implanted. No further complications occurred during follow-up. Conclusion and clinical significance: Given the increasing prevalence of single-piece lOLs implanted in the capsular bag, it is important to recognize UGH syndrome as a rare but potentially serious complication. How to cite this article: Sousa DC, Leal I, Faria MY, Pinto LA. A Rare Manifestation of Uveitis-glaucoma-hyphema Syndrome. J Curr Glaucoma Pract 2016;10(2):76-78. PMID:27536051

  2. Total antioxidant capacity in Eales’ disease, uveitis & cataract

    OpenAIRE

    Selvi, Radhakrishnan; Angayarkanni, Narayanasamy; Biswas, Jyotirmay; Ramakrishnan, Sivaramakrishnan

    2011-01-01

    Background & objectives: The human system possesses antioxidants that act harmoniously to neutralize the harmful oxidants. This study was aimed to evaluate the serum total antioxidant capacity (TAC) as a single parameter in Eales’ disease (ED) and in an acute inflammatory condition such as uveitis and in cataract which is chronic, compared to healthy controls. Methods: The TAC assay was done spectrophotometrically in the serum of Eales’ disease cases (n=20) as well as in other ocular patholog...

  3. Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats.

    Science.gov (United States)

    Nussenblatt, R B; Rodrigues, M M; Wacker, W B; Cevario, S J; Salinas-Carmona, M C; Gery, I

    1981-01-01

    Cyclosporin A (CS-A), a selective inhibitor of T lymphocytes, is reported here to prevent S antigen (S-Ag) induced uveitis in Lewis rats. The S-Ag, found in all mammalian retinas, is uveitogenic under experimental conditions and patients with certain uveitic entities demonstrate cell mediated responses to this antigen. Daily treatment with CS-A (10 mg/kg) begun on the same day as S-Ag immunization totally inhibited the development of the uveitis in this experimental autoimmune model. Moreover a greater CS-A dose (40 mg/kg) efficiently prevented the disease process when therapy was started 7 d after S-Ag immunization. Anti-S-Ag antibody titers were observed to be similar in rats either protected or not protected with CS-A. Our data support strongly the need for T cell participation in this disease model. Since ocular inflammatory disease is an important cause of visual impairment, the data further suggest that CS-A may be useful in the treatment of patients with intractable uveitis. Images PMID:7204576

  4. Controversies in intraocular lens implantation in pediatric uveitis.

    Science.gov (United States)

    Phatak, Sumita; Lowder, Careen; Pavesio, Carlos

    2016-12-01

    Cataract is one of the most common and visually debilitating complications of pediatric uveitis. It develops as a consequence of chronic inflammation and steroid use and is seen most often in juvenile idiopathic arthritis (JIA)-associated uveitis. Cataract extraction with intraocular lens (IOL) insertion has been carried out with a measure of success in non-uveitic pediatric eyes, but in cases of uveitis, multiple factors affect the final outcome. Chronic inflammation and its sequelae such as band keratopathy, posterior synechiae, and cyclitic membranes make surgical intervention more challenging and outcome less certain. Postoperative complications like increased inflammation, glaucoma, posterior capsular opacification, retrolental membranes, and hypotony may compromise the visual outcome. Early refractive correction is imperative in pediatric eyes to prevent amblyopia. The use of contact lenses and intraocular lenses in pediatric uveitic eyes were fraught with complications in the past. Surgical interventions such as vitreo-lensectomy followed by contact lens fitting and small incision cataract surgery followed by different types of intraocular lenses have been utilized, and many reports have been published, albeit in small patient groups. This review analyzes and discusses the existing literature on intraocular lens implantation in cases of pediatric uveitic cataract surgery.

  5. Efficacy of Ozurdex implant in treatment of noninfectious intermediate uveitis

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    Swetha Palla

    2015-01-01

    Full Text Available Aims: To report our experiences using Ozurdex, a biodegradable implant, containing 0.7 mg of dexamethasone in the treatment of noninfectious intermediate uveitis. Settings and Design: Retrospective study design. Methods: We conducted a retrospective study of medical records of patients with noninfectious intermediate uveitis having either cystoid macular edema (CME or vitritis who were not responsive to standard treatment and subsequently received Ozurdex implant from March 2011 to April 2013. The outcomes measured were best-corrected visual acuity, central retinal thickness (CRT, and vitreous haze score. Statistical Analysis Used: Paired t-test was used to test the significance of difference between quantitative variables. A P < 0.05 is taken to denote significant relationship. Results: Twenty eyes of 15 patients with mean age of 39.8 years who received Ozurdex implant were included in the study. The mean baseline visual acuity improved from 0. 666 logarithm of the minimum angle of resolution (logMAR units to 0.479 logMAR units at 6 weeks after the implant. The mean CRT improved from 536.1 to 361.4 microns at 6 weeks postimplant both parameters were statistically significant. The ocular inflammation was controlled in almost all the patients. Cataract and raised intraocular pressure were documented complications. Conclusion: Ozurdex implant is a promising treatment option and efficient in controlling the inflammation and CME in cases of noninfectious intermediate uveitis not responding to standard treatment.

  6. Complement factor B expression profile in a spontaneous uveitis model.

    Science.gov (United States)

    Zipplies, Johanna K; Kirschfink, Michael; Amann, Barbara; Hauck, Stefanie M; Stangassinger, Manfred; Deeg, Cornelia A

    2010-12-01

    Equine recurrent uveitis serves as a spontaneous model for human autoimmune uveitis. Unpredictable relapses and ongoing inflammation in the eyes of diseased horses as well as in humans lead to destruction of the retina and finally result in blindness. However, the molecular mechanisms leading to inflammation and retinal degeneration are not well understood. An initial screening for differentially regulated proteins in sera of uveitic cases compared to healthy controls revealed an increase of the alternative pathway complement component factor B in ERU cases. To determine the activation status of the complement system, sera were subsequently examined for complement split products. We could demonstrate a significant higher concentration of the activation products B/Ba, B/Bb, Bb neoantigen, iC3b and C3d in uveitic condition compared to healthy controls, whereas for C5b-9 no differences were detected. Additionally, we investigated complement activation directly in the retina by immunohistochemistry, since it is the main target organ of this autoimmune disease. Interestingly, infiltrating cells co-expressed activated factor Bb neoantigen, complement split product C3d as well as CD68, a macrophage marker. In this study, we could demonstrate activation of the complement system both systemically as well as in the eye, the target organ of spontaneous recurrent uveitis. Based on these novel findings, we postulate a novel role for macrophages in connection with complement synthesis at the site of inflammation.

  7. Noninfectious uveitis: strategies to optimize treatment compliance and adherence

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    Dolz-Marco R

    2015-08-01

    Full Text Available Rosa Dolz-Marco,1 Roberto Gallego-Pinazo,1 Manuel Díaz-Llopis,2 Emmett T Cunningham Jr,3–6 J Fernando Arévalo7,8 1Unit of Macula, Department of Ophthalmology, University and Polytechnic Hospital La Fe, 2Faculty of Medicine, University of Valencia, Spain; 3Department of Ophthalmology, California Pacific Medical Center, San Francisco, 4Department of Ophthalmology, Stanford University School of Medicine, Stanford, 5The Francis I Proctor Foundation, University of California San Francisco Medical Center, 6West Coast Retina Medical Group, San Francisco, CA, USA; 7Vitreoretina Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 8Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: Noninfectious uveitis includes a heterogenous group of sight-threatening ocular and systemic disorders. Significant progress has been made in the treatment of noninfectious uveitis in recent years, particularly with regard to the effective use of corticosteroids and non-corticosteroid immunosuppressive drugs, including biologic agents. All of these therapeutic approaches are limited, however, by any given patient’s ability to comply with and adhere to their prescribed treatment. In fact, compliance and adherence are among the most important patient-related determinants of treatment success. We discuss strategies to optimize compliance and adherence. Keywords: noninfectious uveitis, intraocular inflammation, immunosuppressive treatment, adherence, compliance, therapeutic failure

  8. In Vivo Bioluminescence Imaging for Longitudinal Monitoring of Inflammation in Animal Models of Uveitis

    Science.gov (United States)

    Gutowski, Michal B.; Wilson, Leslie; Van Gelder, Russell N.; Pepple, Kathryn L.

    2017-01-01

    Purpose We develop a quantitative bioluminescence assay for in vivo longitudinal monitoring of inflammation in animal models of uveitis. Methods Three models of experimental uveitis were induced in C57BL/6 albino mice: primed mycobacterial uveitis (PMU), endotoxin-induced uveitis (EIU), and experimental autoimmune uveitis (EAU). Intraperitoneal injection of luminol sodium salt, which emits light when oxidized, provided the bioluminescence substrate. Bioluminescence images were captured by a PerkinElmer In Vivo Imaging System (IVIS) Spectrum and total bioluminescence was analyzed using Living Image software. Bioluminescence on day zero was compared to bioluminescence on the day of peak inflammation for each model. Longitudinal bioluminescence imaging was performed in EIU and EAU. Results In the presence of luminol, intraocular inflammation generates detectable bioluminescence in three mouse models of uveitis. Peak bioluminescence in inflamed PMU eyes (1.46 × 105 photons/second [p/s]) was significantly increased over baseline (1.47 × 104 p/s, P = 0.01). Peak bioluminescence in inflamed EIU eyes (3.18 × 104 p/s) also was significantly increased over baseline (1.09 × 104 p/s, P = 0.04), and returned to near baseline levels by 48 hours. In EAU, there was a nonsignificant increase in bioluminescence at peak inflammation. Conclusions In vivo bioluminescence may be used as a noninvasive, quantitative measure of intraocular inflammation in animal models of uveitis. Primed mycobacterial uveitis and EIU are both acute models with robust anterior inflammation and demonstrated significant changes in bioluminescence corresponding with peak inflammation. Experimental autoimmune uveitis is a more indolent posterior uveitis and generated a more modest bioluminescent signal. In vivo imaging system bioluminescence is a nonlethal, quantifiable assay that can be used for monitoring inflammation in animal models of uveitis. PMID:28278321

  9. Clinical and epidemiological characteristics of patients with uveitis in an emergency eye care center in Brazil

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    Eduardo Nery Rossi Camilo

    2014-01-01

    Full Text Available Purpose: To analyze the clinical and epidemiological characteristics of patients with uveitis in an emergency eye care center. Methods: We conducted a prospective, observational study of patients with active uveitis admitted between May 2012 and July 2012 to an emergency eye care center. Results: The majority of patients were male (63.2%, with a mean age of 43.2 years; 66.2% patients were of mixed ethnicity, 22.5% were Caucasian, and 11.3% were black. Anterior uveitis was observed in 70.1% patients, posterior uveitis in 26.5%, and panuveitis in 3.4%; no patient was diagnosed with intermediate uveitis. All patients had a sudden and acute presentation. The most frequent symptoms were ocular pain (76.9%, redness (59.8%, and visual blurring (46.2%. The majority of patients had unilateral disease (94.9% with a mean symptom duration of 6.2 days. Diffuse and anterior uveitis were associated with ocular pain (p<0.001. Scotomata and floaters were more frequent in patients with posterior uveitis (p=0.003 and p=0.016, respectively. Patients with anterior uveitis presented with better visual acuity (p=0.025. Granulomatous keratotic precipitates were more frequent in patients with posterior uveitis (p=0.038. An etiological diagnosis based on the evaluation at the emergency center was made in 45 patients (38.5%. Conclusions: Acute anterior uveitis was the most frequent form of uveitis. Initial patient evaluation provided sufficient information for deciding primary therapy and aided in arriving at an etiological diagnosis in a considerable number of patients.

  10. Uveitis in childhood-onset systemic lupus erythematosus patients: a multicenter survey.

    Science.gov (United States)

    Kahwage, Paola Pinheiro; Ferriani, Mariana Paes Leme; Furtado, João M; de Carvalho, Luciana Martins; Pileggi, Gecilmara Salviato; Gomes, Francisco Hugo Rodrigues; Terreri, Maria Teresa; Magalhães, Claudia Saad; Pereira, Rosa Maria Rodrigues; Sacchetti, Silvana Brasilia; Marini, Roberto; Bonfá, Eloisa; Silva, Clovis Artur; Ferriani, Virgínia Paes Leme

    2017-03-01

    The aim of this study is to assess uveitis prevalence in a large cohort of childhood-onset systemic lupus erythematosus (cSLE) patients. A retrospective multicenter cohort study including 852 cSLE patients was performed in ten pediatric rheumatology centers (Brazilian cSLE group). An investigator meeting was held and all participants received database training. Uveitis was diagnosed through clinical assessment by the uveitis expert ophthalmologist of each center. Patients with and without uveitis were assessed for lupus clinical/laboratory features and treatments. Uveitis was observed in 7/852 cSLE patients (0.8%). Two of them had ocular complications: cataract and irreversible blindness in one patient and retinal ischemia with subsequent neovascularization and unilateral blindness in another. Uveitis was identified within the first 6 months of cSLE diagnosis in 6/7 patients (86%). Comparison of a subgroup of cSLE patients with (n = 7) and without uveitis (n = 73) and similar length of disease duration showed that patients with uveitis had increased SLEDAI-2K score (19 vs. 6; p uveitis, as compared to those without this manifestation, respectively. Presence of fever was significantly associated with uveitis, independently of SLEDAI scores or use of intravenous methylprednisolone pulses, as shown by adjusted regression analysis (adjusted prevalence ratio 35.7, 95% CI 2.4-519.6; p Uveitis was a rare and initial manifestation of active cSLE patients. Early recognition is essential due to the possibility of irreversible blindness.

  11. Multiple etiologies of equine recurrent uveitis--A natural model for human autoimmune uveitis: A brief review.

    Science.gov (United States)

    Witkowski, Lucjan; Cywinska, Anna; Paschalis-Trela, Katarzyna; Crisman, Mark; Kita, Jerzy

    2016-02-01

    Equine recurrent uveitis (ERU) has various etiologies, with Leptospira infection and genetic predisposition being the leading risk factors. Regardless of etiology, expression of ocular proteins associated with maintenance of the blood-ocular barrier is impaired in ERU. The recurring-remitting cycle of ERU repeatedly disrupts the blood-ocular barrier, allowing the previously immune-privileged ocular environment to become the site of a progressive local autoimmune pathology that ultimately results in tissue destruction and vision loss. The immune-mediated process involves humoral and cellular mechanisms. Intraocular antibodies either produced in the eye or that leak through the blood-ocular barrier, are often present at higher levels than in serum and react with antigens in ocular tissue of horses with ERU. Ocular infiltration of auto-aggressive lymphocytes occurs with each uveitis episode and is the most crucial contributor to inflammation and eye damage. Recurring uveitis episodes may be initiated when epitopes of an ocular antigen become visible to the immune system (intramolecular spreading) or another autoantigen (intermolecular spreading), resulting in a new inflammatory reaction.

  12. Osteomalacia inducida por tumor: hemangiopericitoma rinosinusal

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    Enriqueta M. Serafini

    2013-02-01

    Full Text Available La osteomalacia inducida por tumor es una rara enfermedad del metabolismo óseo caracterizada por el aumento en la excreción de fosfato a nivel renal seguido de hipofosfatemia. Es causada por agentes fosfatúricos producidos por determinados tumores. La resección total del tumor resulta en la completa reversión de las anormalidades bioquímicas, la desaparición de las manifestaciones clínicas y los hallazgos en los estudios por imágenes. Presentamos el caso de un varón de 61 años con cuadro clínico y laboratorio compatibles con osteomalacia oncogénica inducida por tumor mesenquimático de localización rinosinusal. En nuestro caso el diagnóstico histológico correspondió a una neoplasia de tipo vascular: hemangiopericitoma.

  13. Evaluation of sterile uveitis after iris-fixated phakic intraocular lens implantation

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    Mohamadreza Sedaghat

    2012-01-01

    Conclusion: Although the prognosis is usually benign, sterile uveitis occurred in 10.3% of patients after iris-fixated pIOL implantation. The implantation of a foldable pIOL was the only variable associated with sterile uveitis. Appropriate medical management can be effective treatment, without the need for pIOL replacement.

  14. Potential Predictors of Poor Visual Outcome in Human Leukocyte Antigen-B27-Associated Uveitis

    NARCIS (Netherlands)

    Verhagen, Fleurieke H; Brouwer, Anna H; Kuiper, Jonas J W; Ossewaarde-van Norel, Jeannette; ten Dam-van Loon, Ninette H; de Boer, Joke H

    2016-01-01

    PURPOSE: To identify potential predictors of permanent vision loss in patients with human leukocyte antigen (HLA)-B27-associated uveitis in a tertiary referral center. DESIGN: Retrospective case-control study. METHODS: The charts of 212 patients (338 eyes) with HLA-B27-associated uveitis that visite

  15. The evaluation of uveitis in juvenile idiopathic arthritis (JIA) patients : are current ophthalmologic screening guidelines adequate?

    NARCIS (Netherlands)

    Reininga, J K; Los, L I; Wulffraat, N M; Armbrust, W

    2008-01-01

    OBJECTIVE: The aims of this study are to examine in our juvenile idiopathic arthritis (JIA) population: 1) the prevalence and characteristics of uveitis, 2) the complications and outcome of uveitis, 3) prognostic factors, and 4) the adequacy of the current ophthalmologic screening guidelines. METHOD

  16. Pattern of Uveitis in a Referral Eye Clinic in North India

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    Singh Ramandeep

    2004-01-01

    Full Text Available Purpose: To report the pattern of uveitis in a north Indian tertiary eye center. Methods: A retrospective study was done to identify the pattern of uveitis in a uveitis clinic population of a major referral center in north India from January 1996 to June 2001. A standard clinical protocol, the "naming and meshing" approach with tailored laboratory investigations, was used for the final diagnosis. Results: 1233 patients were included in the study; 641 (51.98% were males and 592 (48.01% females ranging in age from 1.5 to 75 years. The anterior uveitis was seen in 607 patients (49.23% followed by posterior uveitis (247 patients, 20.23%, intermediate uveitis (198 patients, 16.06% and panuveitis (181 patients, 14.68%. A specific diagnosis could be established in 602 patients (48.82%. The infective aetiology was seen in 179 patients, of which tuberculosis was the commonest cause in 125 patients followed by toxoplasmosis (21 patients, 11.7%. Non-infectious aetiology was seen in 423 patients, of which ankylosing spondylitis was the commonest cause in 80 patients followed by sepigionous choroidopathy (62 patients, 14.65% . Conclusion: Tuberculosis and toxoplasmosis were the commonest form of infective uveitis, while ankylosing spondylitis and serpiginous choroidopathy were commonly seen as the non-infective causes of uveitis in North India.

  17. Uveitis in childhood : Complications and treatment with emphasis on juvenile idiopathic arthritis

    NARCIS (Netherlands)

    Sijssens, K.M.

    2008-01-01

    The aim of this study was to gain more insight into the development of complications in childhood uveitis and to evaluate the treatment options for these mostly sight-threatening conditions with emphasis on juvenile idiopathic arthritis (JIA)-associated uveitis. The second aim was to investigate whi

  18. Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis-associated uveitis

    DEFF Research Database (Denmark)

    Heiligenhaus, Arnd; Foeldvari, Ivan; Edelsten, Clive

    2012-01-01

    To develop a set of core outcome measures for use in randomized controlled trials (RCTs) and longitudinal observational studies in juvenile idiopathic arthritis (JIA)-associated uveitis.......To develop a set of core outcome measures for use in randomized controlled trials (RCTs) and longitudinal observational studies in juvenile idiopathic arthritis (JIA)-associated uveitis....

  19. Acute tubulointerstitial nephritis and uveitis syndrome: A report on four adult cases

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    Yosra Ben Ariba

    2017-01-01

    Full Text Available Acute tubulointerstitial nephritis and uveitis (TINU syndrome is a rare disease, generally presenting in children and young women. The interstitial nephritis may precede, follow, or develop concurrent to the uveitis. We report the clinical features and outcomes of four adult patients, aged 41-70 years with the TINU syndrome.

  20. Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease.

    Science.gov (United States)

    Chancellor, John R; Padmanabhan, Sriranjani P; Greenough, Thomas C; Sacra, Richard; Ellison, Richard T; Madoff, Lawrence C; Droms, Rebecca J; Hinkle, David M; Asdourian, George K; Finberg, Robert W; Stroher, Ute; Uyeki, Timothy M; Cerón, Olga M

    2016-02-01

    We report a case of probable Zaire Ebola virus-related ophthalmologic complications in a physician from the United States who contracted Ebola virus disease in Liberia. Uveitis, immune activation, and nonspecific increase in antibody titers developed during convalescence. This case highlights immune phenomena that could complicate management of Ebola virus disease-related uveitis during convalescence.

  1. Effect of vitamin E in the treatment of bovine-albumin-induced uveitis in rabbits.

    Science.gov (United States)

    Yücel, I; Paksoy, N; Yücel, G; Aksu, G; Aksu, T A

    1992-01-01

    In order to assess the role of vitamin E, an antioxidant, in the treatment of uveitis, a controlled experimental study was carried out on 20 New Zealand albino rabbits with bovine-albumin-induced uveitis. In all vitamin-E-treated animals, clinical and histopathological study of the retina and uvea revealed no significant changes in comparison with those in untreated rabbits.

  2. The Role of Gender in Juvenile Idiopathic Arthritis-Associated Uveitis

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    Ahmadreza Moradi

    2014-01-01

    Full Text Available Uveitis is a common complication of juvenile idiopathic arthritis (JIA affecting up to 30% of patients with JIA. Although the typical bilateral chronic anterior uveitis associated with the persistent and extended oligoarticular and polyarticular, rheumatoid factor negative variants of JIA occurs predominantly in girls, boys may be more commonly affected in the HLA-B27 positive, enthesitis variant of JIA. While female gender has been associated with the development of the chronic anterior uveitis in children with JIA, the clinical course of JIA-associated uveitis may be worse in boys than in girls. The purpose of this paper is to review the available published literature to determine the role of gender in the clinical presentation and outcomes of patients with JIA-associated uveitis.

  3. Juvenile idiopathic arthritis-associated uveitis: a nationwide population-based study in Taiwan.

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    Hsin-Hui Yu

    Full Text Available OBJECTIVE: The incidence and prevalence of juvenile idiopathic arthritis (JIA vary widely across the world but data in East Asia is lacking. Uveitis is a serious cause of morbidity in JIA. This study aimed to analyze the incidence and prevalence of JIA, and the characteristics of JIA-associated uveitis in Taiwan. METHODS: A population-based cohort study was conducted using the Taiwan National Health Insurance Research Database. Each patient was individually tracked from 1999 to 2009 to identify the diagnosis of JIA and uveitis using the International Classification of Diseases diagnostic codes. Multivariate logistic regression was used to determine the risk factors and complications of uveitis in patients with JIA. RESULTS: The study cohort had 2636 cases of JIA and included juvenile rheumatoid arthritis (57.7%, enthesitis-related arthritis (ERA (39.2%, and psoriatic arthritis (3.1%. The average annual incidence of JIA and JIA-associated uveitis were 4.93 (range, 3.93-6.23 and 0.25 (range, 0.12-0.37 cases per 100,000 population, respectively. The average period prevalence of JIA was 33.8 cases per 100,000 population. Uveitis occurred in 4.7% of patients with JIA, while JIA-associated uveitis was complicated by cataract (11.2% and glaucoma (24.8%. Enthesitis-related arthritis was significantly associated with uveitis (OR: 3.47; 95% CI: 2.24-5.37 (p<0.0001. Uveitis diagnosed before JIA was the most significant risk factor for complications of glaucoma or cataract (OR: 3.54; 95% CI: 1.44-8.72 (p = 0.006. CONCLUSIONS: The incidence of JIA is low but that of JIA-associated uveitis is increasing. Higher percentage of males in patients with ERA and the strong association between ERA and uveitis are unique for children with JIA in Taiwan. Uveitis diagnosed before arthritis is an important risk factor for complications. Continuous ophthalmologic follow-up is needed for children with JIA or uveitis of unknown etiology.

  4. Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats.

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    Cheng-bo Fang

    Full Text Available PURPOSE: To investigate the efficacy of leflunomide in experimental autoimmune uveitis (EAU in rats. METHODS: Lewis rats were immunized with interphotoreceptor retinoid-binding peptide (IRBP in order to generate EAU. Rats received three dose of leflunomide through intragastric administration (prevention or treatment protocols after immunization at three separate doses (3 mg/kg/d; 6 mg/kg/d; 12 mg/kg/d. Cyclosporin A was administered as a positive control. Rats were euthanized during peak disease activity (day 14 or 15. Treatment effectiveness was evaluated in vivo using clinical EAU scoring (d14 and histopathological evaluation of enucleated eyes after experimental termination. The expression levels of inflammatory cytokines in the serum were quantified by ELISA. Eyeball of rats were harvested and mRNA expression of interleukin 17 (IL17 and IFN-γ were quantified through RT-PCR. Intracellular expression of interleukin (IL-17 in the activated CD4(+ T cells was assessed by flow cytometry. The effects of leflunomide inhibition on immune responses in rats were investigated in isolated lymphocytes. RESULTS: Histopathological and clinical data revealed severe intraocular inflammation in the immunized rat. Inflammation reached its peak on day 14 in this EAU model. Treatment with leflunomide significantly prevented and treated EAU-induced ocular inflammation and decreased clinical and pathological scores compared to vehicle-treated eyes. Gene expression of IL17 and IFN-γ was markedly reduced in leflunomide-treated eyes. Leflunomide significantly decreased the serum levels of IL17 and IFN-γ. The study of IL17+ T cells in peripheral blood and spleen by flow cytometry showed a decreased number of Th17 cell in rats of leflunomide prevented group. Lymphocytes from animals treated with leflunomide had decreased antigen-specific proliferation in vitro compared with lymphocytes from untreated animals. CONCLUSIONS: Oral administration of leflunomide

  5. Caracterização da uveíte na espondilite anquilosante Characterization of uveitis in ankylosing spondylitis

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    Percival Degrava Sampaio-Barros

    2003-12-01

    Full Text Available OBJETIVO: analisar a apresentação clínica e a evolução da uveíte em uma população de 207 pacientes com espondilite anquilosante (EA. MÉTODOS: estudo retrospectivo (1988-2001 analisando 207 pacientes com o diagnóstico de EA segundo os critérios de Nova York modificados. Todos apresentavam investigação clínica (envolvimento axial e periférico, entesopatias, manifestações extra-articulares e radiológica (sacroilíaca, coluna lombar, dorsal e cervical completas, além da pesquisa do HLA-B27 (com seus respectivos alelos, quando possível. Os dados foram comparados com a presença de uveíte durante o período de seguimento dos pacientes. RESULTADOS: trinta pacientes (14,5% apresentaram 55 episódios de uveíte anterior aguda unilateral durante o seguimento ambulatorial. Vinte e sete pacientes encontravam-se em atividade articular da EA no momento da crise de uveíte, enquanto três pacientes encontravam-se inativos do ponto de vista articular. Um único paciente, em tratamento de tuberculose pulmonar, apresentou um episódio de uveíte posterior. Entre os pacientes com uveíte, houve predomínio de sexo masculino (82,6%, raça caucasóide (77,8%, início da EA na idade adulta (83,1%, HLA-B27 positivo (79,2%, sem história familiar de EA (84,5%. Houve associação estatística entre uveíte e idade de início juvenil (p = 0,0094 e entesopatias aquileana (p = 0,0003 e plantar (p = 0,0067. Nenhum paciente apresentou seqüela ocular grave da uveíte. Dezesseis pacientes fizeram uso de sulfassalazina (1,0 g/dia a 2,0 g/dia, por prazo mínimo de seis meses. CONCLUSÕES: a uveíte anterior aguda foi comum na evolução da EA nesta casuística, estando associada preferencialmente à EA de início juvenil e ao acometimento articular entesopático de membros inferiores.OBJECTIVE: To analyze the clinical picture and outcome of uveitis in a series of 207 patients with ankylosing spondylitis (AS. METHODS: Retrospective study (1988-2001 analyzing

  6. Effects of Qingkailing on Experimental Allergic Uveitis in Rabbits

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    Experimental allergic uveitis(EAU)in rabbits was induced by singleintraocular injection of bovine serum albumin(BSA).The average of protein con-centration in aqueous humor of untreated group of rabbits was 14.33±1.21mg/mland the count of tritiated thymidine(~3H-TdR)incorporated into lymphocyte T was3,987±1,156cpm/10~6.The specific antibody responses to BSA in the serum andthe aqueous were 0.508±0.034 and 0.369±0.019(OD)respectively.Meanwhile,the effect of Qingkailing on EAU was observed in comparison wi...

  7. A 10-year review of pediatric uveitis at a Hispanic-dominated tertiary pediatric ophthalmic clinic

    Science.gov (United States)

    Dajee, Kruti P; Rossen, Jennifer Landau; Bratton, Monica L; Whitson, Jess T; He, Yu-Guang

    2016-01-01

    Purpose The aim of this study was to evaluate the characteristics and outcomes of pediatric uveitis cases at a large tertiary referral center in Dallas, TX, USA. Materials and methods The authors performed a retrospective chart review between 2001 and 2011 to identify children with uveitis. Results A total of 46 children (68 eyes) with uveitis were identified. Sixty-seven percent were Hispanic, and the mean age was 9.2 years. The majority of cases were idiopathic (74%). Anterior uveitis accounted for 42% of cases followed by intermediate uveitis/pars planitis (33%), posterior uveitis/retinitis (7%), and panuveitis (20%). Most patients were treated with corticosteroids (98% topical), 52% with systemic immunosuppression therapy, and 30% with surgery. Complications occurred in 74% of patients, with the most common complication being cataract development (26%), followed by posterior synechiae (24%). Twenty-four percent of patients had recurrences. Hispanic patients had worse visual acuities at presentation (P-value =0.073) and follow-up (P-value =0.057), compared to non-Hispanic patients. Conclusion Pediatric uveitis cases seen in a large center in Dallas were largely idiopathic, had commonly developed complications, and were associated with worse visual outcomes in Hispanic patients. PMID:27601874

  8. Two cases of uveitis masquerade syndrome caused by bilateral intraocular large B-cell lymphoma

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    Jovanović Svetlana

    2013-01-01

    Full Text Available Introduction. Sometimes it is not easy to clinically recognize subtle differences between intraocular lymphoma and noninfectious uveitis. The most common lymphoma subtype involving the eye is B-cell lymphoma. Case report. We presented two patients aged 59 and 58 years with infiltration of the subretinal space with a large B-cell non-Hodgkin intraocular lymphoma. The patients originally had clinically masked syndrome in the form of intermediate uveitis. As it was a corticosteroid-resistant uveitis, we focused on the possible diagnosis of neoplastic causes of this syndrome. During hospitalization, the neurological symptoms emerged and multiple subretinal changes accompanied by yellowish white patches of retinal pigment epithelium with signs of vitritis, which made us suspect the intraocular lymphoma. Endocranial magnetic resonance imaging established tumorous infiltration in the region of the left hemisphere of the cerebellum. The histopathological finding confirmed the diagnosis of large B-cell non-Hodgkin lymphoma of risk moderate degree, immunoblast - centroblast cytological type. The other patient had clinical chronic uveitis accompanied by yellowish shaped white echographic changes of the retina and localized changes in the level of the subretina. The diagnosis of lymphoma was made by brain biopsy. Conclusion. Uveitis masquerade syndrome should be considered in all patients over 40 years with idiopathic steroid-resistant uveitis. Treatment begun on time can affect the course and improve the prognosis of uveitis masquerade syndrome (UMS and systemic disease.

  9. A Rare Case of Tubulointerstitial Nephritis and Uveitis Syndrome Treated with a Multi-Specialty Approach.

    Science.gov (United States)

    Purt, Boonkit; Hiremath, Siri; Smith, Sarah; Erzurum, Sergul; Sarac, Erdal

    2016-11-21

    BACKGROUND It is important for an ophthalmologist and nephrologist to look for hidden causes of uveitis and nephritis, respectively. Delay in diagnosis leads to increased morbidity and failure to systemically manage the patient results in future recurrence of disease. It is likely that TINU remains underdiagnosed and could potentially account for some of the cases of idiopathic uveitis, especially when greater than 50% of uveitis cases have no identifiable cause. Fewer than 300 cases of tubulointerstitial nephritis and uveitis (TINU) syndrome have been reported. In TINU syndrome, inflammation affects the renal tubules, interstitial tissue, and uveal tract. Its pathogenesis remains poorly understood. CASE REPORT We report a rare case of TINU syndrome in a 23-year-old female who was treated using a multispecialty approach. Her primary care physician diagnosed her with proteinuria and acute kidney injury and referred her to the nephrologist, who later referred her to the ophthalmologist. A left kidney biopsy confirmed acute interstitial nephritis. Following the discovery of a "pink eye", the patient was referred to ophthalmology and diagnosed with anterior uveitis, confirming TINU syndrome. Without the additional findings of uveitis, the diagnosis would have been missed. Resolution was obtained through steroid therapy. CONCLUSIONS Correctly diagnosing TINU syndrome requires a multispecialty approach and may not be obvious upon initial presentation. Therefore, the ophthalmologist needs to consider TINU in the differential diagnosis for a patient with bilateral uveitis and evaluate a urinalysis for proteinuria as part of the work up.

  10. [Recurrent new-onset uveitis in a patient with rheumatoid arthritis during anti-TNFalpha treatment].

    Science.gov (United States)

    Di Gangi, M; Foti, R; Leonardi, R; Leonetti, C; Castellino, P

    2007-01-01

    Inflammation involving the uveal tract of the eye, termed uveitis, is frequently associated with various rheumatic disease, including seronegative spondylarthropathies, juvenile rheumatoid arthritis, Crohn's disease and Behçet's disease. Scleritis and keratitis may be associated with rheumatoid arthritis and systemic vasculitides such as Wegener's granulomatosis. Immune-mediated uveitis can have a chronic relapsing course and produce numerous possible complications, many of which can result in permanent vision loss. Treatment typically includes topical or systemic corticosteroids with cycloplegic-mydriatic drugs and/or noncorticosteroid immunosuppressants, but often there is an insufficient clinical effectiveness. Anti-TNFalpha therapy is promising in the treatment of sight threatening uveitis, particularly in patients with Behçet's disease. However, there have been also reports of new-onset uveitis during treatment of joint disease with TNFalpha inhibitors. We describe a case of new-onset uveitis in a patient with rheumatoid arthritis during therapy with etanercept at first and infliximab at last. Although we cannot exclude uveitis as linked to rheumatoid arthritis, it is unlike that the uveitis arises when the joint disease is well controlled. The hypothetical paradoxical effect of anti-TNF is here discussed.

  11. Recurrent new-onset uveitis in a patient with rheumatoid arthritis during anti-TNFα treatment

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    C. Leonetti

    2011-09-01

    Full Text Available Inflammation involving the uveal tract of the eye, termed uveitis, is frequently associated with various rheumatic disease, including seronegative spondylarthropathies, juvenile rheumatoid arthritis, Crohn’s disease and Behçet’s disease. Scleritis and keratitis may be associated with rheumatoid arthritis and systemic vasculitides such as Wegener’s granulomatosis. Immune-mediated uveitis can have a chronic relapsing course and produce numerous possible complications, many of which can result in permanent vision loss. Treatment typically includes topical or systemic corticosteroids with cycloplegic-mydriatic drugs and/or noncorticosteroid immunosuppressants, but often there is an insufficient clinical effectiveness. Anti-TNFα therapy is promising in the treatment of sight threatening uveitis, particularly in patients with Behçet’s disease. However, there have been also reports of new-onset uveitis during treatment of joint disease with TNFα inhibitors. We describe a case of new-onset uveitis in a patient with rheumatoid arthritis during therapy with etanercept at first and infliximab at last. Although we cannot exclude uveitis as linked to rheumatoid arthritis, it is unlike that the uveitis arises when the joint disease is well controlled. The hypothetical paradoxical effect of anti-TNF is here discussed.

  12. Demographic, clinical, laboratory and treatment characteristics of spondyloarthritis patients with and without acute anterior uveitis

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    Marcelo Gehlen

    Full Text Available CONTEXT AND OBJECTIVE: Acute anterior uveitis is a common extra-articular manifestation in spondyloarthritis patients. The aim of this study was to compare demographic, clinical, laboratory and treatment data among spondyloarthritis patients with and without acute anterior uveitis. DESIGN AND SETTING: This was a cross-sectional analytical study at the Rheumatology Outpatient Clinic of the Evangelical University Hospital, Curitiba, Brazil. METHODS: Spondyloarthritis patients with without acute anterior uveitis were compared regarding demographic data, spondyloarthritis subtype, peripheral arthritis, enthesitis, disease activity, functional index, physical examination, radiological involvement, HLA-B27 and treatment. RESULTS: Presence of acute anterior uveitis was not found to have any relationship with functional index, degree of radiological involvement, peripheral arthritis or enthesitis. Acute anterior uveitis showed a negative association with skin manifestations (P = 0.04 and a trend towards higher disease activity (P = 0.06. CONCLUSION: In the study sample, it could not be shown that AAU had any association with the functional and radiological prognoses. The patients with spondyloarthritis with and without acute anterior uveitis did not differ clinically except for a higher proportion of ankylosing spondylitis and smaller presence of skin involvement in those with uveitis.

  13. Uveitis in horses induced by interphotoreceptor retinoid-binding protein is similar to the spontaneous disease.

    Science.gov (United States)

    Deeg, Cornelia A; Thurau, Stephan R; Gerhards, Hartmut; Ehrenhofer, Marion; Wildner, Gerhild; Kaspers, Bernd

    2002-09-01

    Equine recurrent uveitis (ERU) is an inflammatory eye disease with high similarity to uveitis in man. It is the only spontaneous animal model for uveitis and the most frequent eye disease in horses affecting up to 10% of the population. To further investigate the pathophysiology of ERU we now report the establishment of an inducible uveitis model in horses. An ERU-like disease was elicited in seven out of seven horses by injection of interphotoreceptor retinoid-binding protein (IRBP) in complete Freund's adjuvant. Control horses did not develop uveitis. The disease model is characterized by a highly reproducible disease course and recurrent episodes with an identical time course elicited in all horses by repeated IRBP injections. The histology revealed the formation of lymphoid follicle-like structures in the eyes and an intraocular infiltration dominated by CD3(+) lymphocytes, morphological patterns typical for the spontaneous disease. Antigen-specific T cell proliferation of PBL was monitored prior to clinical uveitis and during disease episodes. An initial T cell response to IRBP-derived peptides was followed by epitope spreading to S-antigen-derived peptides in response to subsequent immunizations. Thus, horse experimental uveitis represents a valuable disease model for comparative studies with the spontaneous disease and the investigation of immunomodulatory therapeutic approaches after onset of the disease.

  14. Etanercept therapy-associated acute uveitis: a case report and literature review.

    Science.gov (United States)

    Wang, F; Wang, N-S

    2009-01-01

    A female patient diagnosed with ankylosing spondylitis experienced a new onset acute iritis following the initiation of etanercept therapy and recurrent episodes of iritis continues during the treatment of etanercept. Etanercept-associated iritis was suspected. Anti-TNF therapies can alleviate uveitis in some studies, but in some other anecdotal reports etanercept is considered as the main cause of uveitis. A literature review is presented below. For clinicians, more attention must be paid to the potential association between uveitis or iritis and etanercept, and more careful surveillance of patients under etanercept treatment is necessary.

  15. Anterior uveitis following eyebrow epilation with alexandrite laser

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    Karabela Y

    2015-09-01

    Full Text Available Yunus Karabela,1 Mustafa Eliaçik2 1Department of Ophthalmology, Esenler Hospital, Istanbul Medipol University, Istanbul, Turkey; 2Department of Ophthalmology, Kadiköy Medipol Hospital, Istanbul Medipol University, Istanbul, Turkey Abstract: Ocular tissues are known to be sensitive to damage from exposure to laser emissions. This study reports the case of a female patient with acute unilateral anterior uveitis caused by alexandrite laser-assisted hair removal of the eyebrows. We report a 38-year-old female who presented with unilateral eye pain, redness, and photophobia after receiving alexandrite (755 nm laser epilation of both eyebrows. Best corrected visual acuity was 20/20 in both eyes. Right eye examination was normal. Left eye examination showed conjunctival injection and 2+/3+ cells in the anterior chamber. Intraocular pressure and fundus examination were normal. Topical steroids and cycloplegic drops were prescribed for 3 weeks. At the end of the 3-week follow-up, best corrected visual acuity was 20/20, and intraocular pressure and fundus examination were normal in both eyes. The left eye was white, and the anterior chamber was clear. The patient continues to be monitored. In conclusion, without adequate protective eyewear, laser hair removal of the eyebrows with alexandrite laser can lead to ocular damage. Keywords: uveitis, laser exposure, photothermolysis, laser hair removal, photoepilation

  16. A case of anterior ischemic optic neuropathy associated with uveitis

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    Sugahara M

    2013-05-01

    Full Text Available Michitaka Sugahara, Takayuki Fujimoto, Kyoko Shidara, Kenji Inoue, Masato Wakakura Inouye Eye Hospital, Tokyo, Japan Introduction: Here, we describe a patient who presented with anterior ischemic optic neuropathy (AION and subsequently developed uveitis. Case: A 69-year-old man was referred to our hospital and initially presented with best-corrected visual acuities (BCVA of 20/40 (right eye and 20/1000 (left eye and relative afferent pupillary defect. Slit-lamp examination revealed no signs of ocular inflammation in either eye. Fundus examination revealed left-eye swelling and a pale superior optic disc, and Goldmann perimetry revealed left-eye inferior hemianopia. The patient was diagnosed with nonarteritic AION in the left eye. One week later, the patient returned to the hospital because of vision loss. The BCVA of the left eye was so poor that the patient could only count fingers. Slit-lamp examination revealed 1+ cells in the anterior chamber and the anterior vitreous in both eyes. Funduscopic examination revealed vasculitis and exudates in both eyes. The patient was diagnosed with bilateral panuveitis, and treatment with topical betamethasone was started. No other physical findings resulting from other autoimmune or infectious diseases were found. No additional treatments were administered, and optic disc edema in the left eye improved, and the retinal exudates disappeared in 3 months. The patient's BCVA improved after cataract surgery was performed. Conclusion: Panuveitis most likely manifests after the development of AION. Keywords: anterior ischemic optic neuropathy, uveitis

  17. Effects of different antioxidants on lens-induced uveitis.

    Science.gov (United States)

    Koch, F H; Augustin, A J; Grus, F H; Spitznas, M

    1996-07-01

    For evaluation of the effects of different free-radical scavengers on biochemical changes in lens-induced uveitis (LIU), ten male Wistar rats were sensitized for 8 weeks using bovine lens protein and Freund's adjuvant. The uveitis was induced by disruption of the lens capsule. One group of animals received superoxide dismutase and catalase (SOD/CAT); a second group of animals was treated with vitamin E. Lipid peroxides (LPO) of the retinal tissue and aqueous humor served as parameter of oxidative tissue damage. Glutathione (GSH/GSSG) of the aqueous humor was evaluated as a parameter of the tissue's redox state. For evaluation of the inflammatory response, myeloperoxidase activity (MPO) was determined in the iris/ciliary-body complex. SOD/CAT produced no improvement in the significantly (P vitamin E treatment the GSH/GSSG and LPO values in aqueous humor were markedly improved as compared with controls. Retinal LPO values were significantly (P vitamin E can do so. However, the inflammatory response itself is not reduced. To achieve global results, drugs are necessary that act on both free radicals produced by noninflammatory pathways and those originating from inflammation.

  18. Abiotic alterations caused by forest fragmentation affect tree regeneration: a shade and drought tolerance gradient in the remnants of Coastal Maulino Forest Alteraciones abióticas causadas por la fragmentación del bosque afectan la regeneración arbórea: un gradiente de tolerancia a la sombra y la sequía en los remanentes del Bosque Maulino Costero

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    PABLO C GUERRERO

    2009-01-01

    by regeneration niche attributes for implementing conservation actions and ecological restoration.La regeneración en plantas está determinada por las diferencias de luz y humedad del suelo entre hábitats, ambas variables son modificadas por la fragmentación de bosques a gran escala. Varios estudios consideran esas alteraciones como parte del mecanismo involucrado en el cambio comunitario en bosques tropicales. Sin embargo, en bosques mediterráneos y deciduos esa tendencia podría ser más severa, debido a que las plantas presentan un "trade off" entre la tolerancia a la sombra y a la sequía. Nuestro estudio fue realizado en el Bosque Maulino Costero: Reserva Nacional Los Queules (RNLQ y fragmentos aledaños de bosque. Hipotetizamos que Aristotelia chilensis (sombra intolerante pero tolerante a la sequía debería aumentar su regeneración en fragmentos pequeños de bosque, como consecuencia del cambio en la idoneidad del habitat (i.e. más luminoso y seco, mientras que, Cryptocarya alba (sombra tolerante pero sequía intolerante debería reducir su regeneración en fragmentos pequeños de bosque. Nosotros además esperamos que Nothofagus glauca y N. obliqua, ambas con tolerancias a la sombra y a la sequía intermedias entre A. chilensis y C. alba, deberían responder en menor medida a la fragmentación del bosque. En este estudio utilizamos dos evaluaciones: (i la abundancia de plántulas y juveniles a través de observaciones de campo y (ii la germinación y establecimiento de plántulas vía un experimento de campo. Los patrones de regeneración natural de C. alba indican una reducción en la regeneración dentro de los fragmentos pequeños de bosque comparado con la RNLQ, a pesar de que en el experimento de campo, la proporción de semillas germinadas, de plántulas establecidas y reclutadas no variaron entre hábitats. Por el contrario, la regeneración de A. chilensis y de N. glauca fueron favorecidas por la fragmentación del bosque, con un aumento en las

  19. O papel das quimiocinas nas uveítes The role of chemokines in uveitis

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    Roberto Martins Gonçalves

    2007-03-01

    Full Text Available A inflamação é parte do processo fisiológico que visa reparar o dano tecidual causado por infecção, trauma, auto-imunidade. Quando este processo fisiológico encontra-se alterado, pode contribuir para o aumento do dano tecidual. As quimiocinas e seus receptores são importantes elementos envolvidos no processo de migração celular para os tecidos inflamados. Nas doenças oculares, principalmente nas uveítes, estas proteínas estão sendo identificadas como importantes mediadores da resposta inflamatória. Esta revisão visa discutir o papel das quimiocinas em diversas doenças oculares, dando ênfase aos processos uveíticos.Inflammation is part of the physiological process that aims at repairing the damage produced by different causes such as infection, trauma, and autoimmune disease. However, when this physiological process is not regulated, it can contribute to the increase in tissue damage. Chemokines and their receptors are major factors involved in the process of cell migration into inflamed tissues. In the ocular diseases, mainly in uveitis, such proteins have been identified as important mediators of the inflammation process. This review discusses the role of chemokines in several ocular diseases, with emphasis on the uveitic process.

  20. Pansinusitis y afectación intracraneal por implante dental Pansinusitis and intracranial impact of a dental implant

    OpenAIRE

    Josep Rubio-Palau; Jordi García-Linares; Javier Gutiérrez-Santamaría; Juan Antonio Hueto-Madrid; Mitchel Chávez-Gatty; Eduard Ferrés-Padró

    2012-01-01

    Las sinusitis odontógenas son una patología relativamente frecuente causada por infecciones dentales, quistes periapicales así como tras procedimientos bucodentales como una endodoncia, una elevación sinusal o la colocación de un implante. A continuación se presenta un caso extremo de una pansinusitis derecha con fistulización a espacio epidural causada por un implante osteointegrado. Ante la sospecha de una sinusitis maxilar de origen odontogénico se debe iniciar rápidamente un tratamiento a...

  1. Tubercular Uveitis with Ocular Manifestation as the First Presentation of Tuberculosis: A Case Series.

    Science.gov (United States)

    Shah, Jayashree S; Shetty, Niharika; Shah, Sharath Kumar D; Shah, Neelesh Kumar S

    2016-03-01

    Tuberculosis is very common disease in India. It is one of the most common causes of Granulomatous Uveitis in our Country even today. So the strongest suspicion in our mind when we are treating a case of Uveitis, should be TB. We reviewed all the cases of clinically suspected ocular tuberculosis attending the Ophthalmology OPD of Sri Siddhartha Medical College between December 2012 and December 2014 who were refractory to routine uveitis management and later on responded to anti-Tubercular treatment. History of TB contact, Ocular manifestation, Demographic Profile of the patients, Diagnostic test, Treatment regime were looked into. Here by we present a case series of 15 cases of refractory uveitis that later were detected to be of tuberculous origin. We studied the characteristic features, complications and correlation of mantoux test, ESR and Koch's contact with these cases.

  2. Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept

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    Bernd Raffeiner

    2014-01-01

    Full Text Available Ankylosing spondylitis (AS is presented with axial and peripheral articular involvement. Uveitis is a severe and rather specific manifestation of AS. Biologics targeting tumor necrosis factor (TNF α are effective on both articular and ocular manifestations of disease. The occurrence of uveitis in patients that never had eye involvement or the relapse of uveitis is described during anti-TNFα treatment. The frequency of these events is slightly higher during therapy with etanercept. The available TNFα blockers show different pharmacokinetics and pharmacodynamics yielding different biological effects. There is an ongoing debate whether uveitis during anti-TNFα has to be considered as paradoxical effect or an inadequate response to therapy. Here, we present a case report and review what the evidences for the two hypotheses are.

  3. [Multiple pulmonary nodules and posterior uveitis as unusual manifestation of pulmonary tuberculosis].

    Science.gov (United States)

    Ibarburen González-Arenas, C; Zapatero Gaviria, A; Gómez Santos, D; García-Castaño, B; Tomás Ros, M; Merino Morales, F

    1990-12-01

    Pulmonar tuberculosis still being one of the diseases more frequent in our area, this producing different clinical and radiological presentation. A case with posterior uveitis and bilateral lungs nodules which required a thoracotomy to perform a diagnosis, is presented.

  4. Fragilización por envejecimiento de aceros inoxidables moldeados

    OpenAIRE

    Mazorra Incera, Luis; Gutiérrez-Solana Salcedo, Federico; González Martínez, Javier Jesús; Varona Ruiz, José María

    1989-01-01

    RESUMEN. En este artículo se presenta, por una parte, la exposición resumida de los modelos teóricos existentes sobre la fragilización de aceros inoxidables moldeados austenoferríticos causada por envejecimiento térmico a 280ºC y, por otra, el análisis-aplicación a un acero real fragilizado, procedente del circuito de recirculación de una central nuclear. Los resultados obtenidos advierten de una importante fragilización al prever una reducción del 50% de la tenacidad a temperatura ambiente e...

  5. Anti-TNFα agents and methotrexate in spondyloarthritis related uveitis in a Chinese population.

    Science.gov (United States)

    Lian, Fan; Zhou, Jun; Wei, Cui; Wang, Yu; Xu, Hanshi; Liang, Liuqin; Yang, Xiuyan

    2015-11-01

    This study seeks to evaluate the clinical characteristics of spondyloarthritis (SpA)-related uveitis in a cohort from South China and to assess the efficacy and safety of therapies based on TNF blockers. SpA patients with uveitis admitted to a south China hospital were enrolled. Demographic information, clinical characteristics, laboratory findings, intraocular inflammation, visual acuity, macular thickness, and treatments were documented. Of the 1,036 SpA patients reviewed, 182 had uveitis. Ankylosing spondylitis (AS) was the most common subtype. Unilateral uveitis was found in 51 cases (51/182, 28.0%), and unilateral alternating uveitis was found in 75 cases (75/182, 41.2%). Half of the cases were recurrent uveitis (52.2%), and acute onset was common (76.4%). The most serious complication was vision loss (0.5%). No significant difference in disease activity was found between the SpA patients with or without uveitis. Predominant improvements were found in cases treated with all three anti-TNFs (infliximab, adalimumab, and etanercept) and anti-TNFs plus methotrexate (MTX). Monotherapy of methotrexate was not adequate for inducing remission. Monotherapy of etanercept was not as effective as adalimumab and infliximab, mainly in the prevention of recurrence. No significant difference in effectiveness was found among the three anti-TNFs if MTX was added. Etanercept plus MTX were well tolerated. Infliximab and adalimumab were associated with more tuberculosis and/or hepatitis flares. Uveitis is common in SpA patients. Severe complications may develop in prolonged and intractable cases. Treatments based on anti-TNFs had good clinical response, and better safety documentation were observed in etanercept plus MTX compared to the other two anti-TNF monoclonal antibodies plus MTX.

  6. Update on the use of systemic biologic agents in the treatment of noninfectious uveitis

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    Pasadhika S

    2014-02-01

    Full Text Available Sirichai Pasadhika,1 James T Rosenbaum2 1Department of Ophthalmology, Southern Arizona Veterans Administration Health Care System, Tucson, AZ, USA; 2Legacy Devers Eye Institute, Portland, OR, USA Abstract: Uveitis is one of the leading causes of blindness worldwide. Noninfectious uveitis may be associated with other systemic conditions, such as human leukocyte antigen B27-related spondyloarthropathies, inflammatory bowel disease, juvenile idiopathic arthritis, Behçet's disease, and sarcoidosis. Conventional therapy with corticosteroids and immunosuppressive agents (such as methotrexate, azathioprine, mycophenolate mofetil, and cyclosporine may not be sufficient to control ocular inflammation or prevent non-ophthalmic complications in refractory patients. Off-label use of biologic response modifiers has been studied as primary and secondary therapeutic agents. They are very useful when conventional immunosuppressive therapy has failed or has been poorly tolerated, or to treat concomitant ophthalmic and systemic inflammation that might benefit from these medications. Biologic therapy, primarily infliximab, and adalimumab, have been shown to be rapidly effective for the treatment of various subtypes of refractory uveitis and retinal vasculitis, especially Behçet's disease-related eye conditions and the uveitis associated with juvenile idiopathic arthritis. Other agents such as golimumab, abatacept, canakinumab, gevokizumab, tocilizumab, and alemtuzumab may have great future promise for the treatment of uveitis. It has been shown that with proper monitoring, biologic therapy can significantly improve quality of life in patients with uveitis, particularly those with concurrent systemic symptoms. However, given high cost as well as the limited long-term safety data, we do not routinely recommend biologics as first-line therapy for noninfectious uveitis in most patients. These agents should be used with caution by experienced clinicians. The present

  7. Lymphocyte Proliferation Response to S Antigen in Patients with Uveitis and Optic Neuritis

    Institute of Scientific and Technical Information of China (English)

    PeixianRen; XiuzhenYan

    1995-01-01

    Purpose:To evaluate the autoimmunity which may play a major role in the etiolo-gy of certain forms of uveitis and optic neuritis.Methods:lymphocyte proliferation response to retinal soluble antigen in vitro by gy of certain forms of uveitis and optic neuritis.Methods:Lymphocyte proliferation response toretinal soluble antigen in vitro by incoperation3H-thymidine withDNA was tested in 115patients with anterior u-veitis,posterior/pan-uveitis,optic neuritis,and 50volunteers with unrelated diseases such as congenital ptosis,strabismus,or completely healthy persons as control.Results:The positive rate of lymphocyte stimulation was34%(18/53)in anteri-or uveitis,41.5%(17/41)in posterior/pan-uveitis,and57.1%(12/21)in optic euritis,The results in the experimental groups were significantly different from those of the control group(x2=14.76,P<0.05,x2=19.14P<0.005,x2=26.38,P<0.005,respectively).Conclusion:The autoimmunity plays a role in the patogenesis in certain forms of uveitis and optic neuritis,Such immune responses may be secondary to the expo-sition or release of retinal antigens by various causes,leading to activation or augmentation of meager or low-affinity S antigen specific lymphocytes which may preexist in the circulation and starting the pathogenic autoimmune process.Eye Science 1995;11:120-123.

  8. High Levels of Serum Ubiquitin and Proteasome in a Case of HLA-B27 Uveitis

    Science.gov (United States)

    Rossi, Settimio; Gesualdo, Carlo; Maisto, Rosa; Trotta, Maria Consiglia; Di Carluccio, Nadia; Brigida, Annalisa; Di Iorio, Valentina; Testa, Francesco; Simonelli, Francesca; D’Amico, Michele; Di Filippo, Clara

    2017-01-01

    In this paper, the authors describe a case of high serum levels of ubiquitin and proteasome in a woman under an acute attack of autoimmune uveitis. The woman was 52 years old, diagnosed as positive for the Human leukocyte antigen-B27 gene, and came to our observation in January 2013 claiming a severe uveitis attack that involved the right eye. During the acute attack of uveitis, this woman had normal serum biochemical parameters but higher levels of serum ubiquitin and proteasome 20S subunit, with respect to a healthy volunteer matched for age and sex. These levels correlated well with the clinical score attributed to uveitis. After the patient was admitted to therapy, she received oral prednisone in a de-escalation protocol (doses from 50 to 5 mg/day) for four weeks. Following this therapy, she had an expected reduction of clinical signs and score for uveitis, but concomitantly she had a reduction of the serum levels of ubiquitin, poliubiquitinated proteins (MAb-FK1) and proteasome 20S activity. Therefore, a role for ubiquitin and proteasome in the development of human autoimmune uveitis has been hypothesized. PMID:28245629

  9. EPIDEMIOLOGICAL ASPECTS OF LEAF BLIGHT OF CARROT (Daucus carota L. CAUSED BY Alternaria dauci (KÜHN GROVES & SKOLKO: SURVIVAL OF Alternaria dauci IN VEGETAL RESIDUES OF CARROT (Daucus carota L. CROP ASPECTOS EPIDEMIOLÓGICOS DA QUEIMA DAS FOLHAS DA CENOURA (Daucus carota L. CAUSADA POR Alternaria dauci (Kühn GROVES & SKOLKO: Sobrevivência de Alternaria dauci (Kühn Groves & SKOLKO em restos culturais da cenoura (Daucus carota L.

    Directory of Open Access Journals (Sweden)

    Geraldo Martins Chaves

    2007-09-01

    Full Text Available

    The spore viability of Alternaria dauci (Kühn Groves & Skolko in carrot (Daucus carota L. debris which were kept at different levels of temperature and relative humidity, without light, was studied. The temperature levels tested were 8, 16, 24 and 32°C, and the relative humidity levels 3, 18, 51, 73 and 100%. The treatments were different combinations of these levels. Humidity was the more important factor in preserving the fungus spore ability to germinate and its infectivity. Under conditions of high relative humidity and temperatures of 24 and 32°C, the spores rapidly lost their viability. This did not happen when the relative humidity was equal to, or below, 51%. The survival of fungus mycelium on carrot petioles was studied in non-treated organic soil, at different humidity levels, at three different depths, during a period of 120 days. Soil humidity was the factor of major significance in the persistence of the mycelium, followed by depths and time factors. In petioles kept at depths of 10 and 20 cm in humid soil, the survival was greatly reduced, while survival was markedly higher in those kept at the surface of dry soil. The effect of humidity on the viability of mycelium was studied also under soiless condition. Petioles were maintained in relative humidity controlled chamber, at 24°C. In saturated atmosphere (100% humidity, the mycelium viability was lost in less than 20 days. It was concluded that both, the conidial and mycelial form of Alternaria dauci are quite sensitive to high humidity levels.

    Estudou-se a sobrevivência das formas conidial e miceliana de Alternaria dauci, respectivamente, sobre folhas necrosadas e pecíolos de cenoura, sob diferentes condições mesológicas. Os esporos do fungo sobre conidióforos em folhas necrosadas de cenoura foram mantidos por 120 dias sob condi

  10. Uveitis and glaucoma: new insights in the pathogenesis and treatment.

    Science.gov (United States)

    Sng, Chelvin C A; Ang, Marcus; Barton, Keith

    2015-01-01

    Glaucoma is a potentially blinding complication of uveitis, where intraocular inflammation, secondary corticosteroid response, and varying types and degrees of angle abnormalities contribute to its pathogenesis. Management of uveitic glaucoma remains challenging. Treatment is targeted at reducing the inflammation and lowering the intraocular pressure. Recent studies have highlighted the role of viruses, such as cytomegalovirus, herpes simplex virus, and more recently Ebola virus, in the pathogenesis of uveitic glaucoma. Antiviral therapy may be beneficial in eyes with detectable viral DNA. The success of glaucoma surgery is decreased in eyes with uveitic glaucoma, and surgical interventions are associated with a higher incidence of postoperative complications. Novel glaucoma surgical and laser treatments may improve the predictability of surgery for uveitic glaucoma, but these require further evaluation.

  11. [Posterior uveitis caused by highly malignant B cell lymphoma].

    Science.gov (United States)

    Held, R; Eckardt, C; Brix, F; Feller, A C

    1989-01-01

    A diagnostic vitrectomy was performed on three patients with posterior uveitis of unknown origin and whose vitrous body was markedly affected. In all cases, cells of high-grade B-cell lymphoma (earlier referred to as reticulum cell sarcoma) were identified by cytological analysis of the specimen. In addition to the ocular findings, one of the three patients showed clinical and radiological evidence of a tumorous mass in the area of the right thalamus at the time of diagnosis. This was interpreted as a cerebral manifestation of the lymphoma. Initially, the other two patients did not show any cerebral involvement. One of them, however, developed clinical symptoms 9 months after diagnosis, which were radiologically verified as tumor infiltration of the cerebellum and the diencephalon. Under radiation therapy, the ocular findings disappeared within a few weeks.

  12. Meningoencefalite causada pelo vírus vacinal da febre amarela transmitido pelo leite materno

    OpenAIRE

    Cristiane Traiber; Priscila Coelho-Amaral; Valéria Raymundo Fonteles Ritter; Annelise Winge

    2011-01-01

    OBJETIVO: Relatar um caso de meningoencefalite, provavelmente causada pelo vírus vacinal da febre amarela transmitido pelo leite materno. DESCRIÇÃO: Paciente de 38 dias de idade, internado em 23/05/09 para investigação de febre. No dia 25/05/09 iniciaram-se as crises convulsivas. O exame do líquido cefalorraquidiano (LCR) foi sugestivo de meningoencefalite. A mãe havia recebido dose da vacina contra febre amarela e o bebê estava em aleitamento materno exclusivo. Recebeu alta com controle das ...

  13. Clinical uveitis evaluation and its value in the diagnosis of spondyloarthritis

    Directory of Open Access Journals (Sweden)

    Alla Aleksandrovna Godzenko

    2011-01-01

    Full Text Available Objective: to estimate the value of clinical parameters of uveitis for the diagnosis of spondyloarthritis (SA. Subjects and methods. One hundred and five uveitis patients referred by ophthalmologists to the Research Institute of Rheumatology, Russian Academy of Medical Sciences, in 2007–2009 were examined. X-ray study of the pelvis and lumbar spine, HLA-B27 test, and objective examination were performed in all the patients to detect inflammatory back pain, arthritis, and enthesitis. Results. The diagnosis of SA was verified in 60 patients: 24 had ankylosing spondylitis, 2 had reactive arthritis, and 38 had undifferentiat ed SA. The diagnosis of SA was discarded in 45 patients. Subsequent examination of these patients diagnosed BehНet's disease in 2 of them, sarcoidosis in 1, toxoplasmosis in 4, virus infection-associated uveitis in 8, Fuchs' syndrome in 1, and unspecified uveitis in 29. There was unilateral uveitis in 51 (85% of the 60 patients with SP and in 26 (58% of the 45 patients without SP (p = 0.0033; alternat ing eye lesion in 30 (50% of the 60 patients with SP and in 4 (8.9% of the 45 patients without SP (p = 0.00001; anterior uveitis in 57 (95% of the 60 patients with SP and in 32 of the 45 patients without SP (p = 0.0017; posterior uveitis in 6 (10% of the 60 patients with SP and in 20 (44% of the 45 patients without SP (p = 0.0001; panuveitis in 2 (3.3% of the 60 patients with SP and in 10 (22.2% of the 45 patients without SP (p = 0.0039, acute recurrent uveitis in 15 (33.3% of the 45 patients without SP and in 44 (73% of the 60 patients with SP (p = 0.0001. The age at onset was less than 30 years in 38 patients with SP and in 19 patients without SP (p = 0.04. Conclusion. The estimation of the location and course of uveitis is important in diagnosing SP that is probable in patients with acute anteri or unilateral uveitis with alternating eye lesion, which occurred before the age of 30 years.

  14. Alteraciones histológicas en el intestino delgado en Tupinambis rufescens (Sauria: Teiidae causadas por Diaphanocephalus galestus (Nematoda: Diaphanocephalidae

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    Spinelli, C. Mónica

    1992-01-01

    Full Text Available Histopathological changes in the gut of the lizard T. rufescens due to the parasitic worm D. galeatus are described here. Superficial damage of the mucosae due to mechanical action of bucal capsule, without involving deeper layers; their implication in the metabolism and immunity of the host.

  15. HIPERAMONEMIA NEONATAL CAUSADA POR DEFECTOS DEL CICLO DE LA UREA Neonatal hyperammonemia in urea cycle disorders patients

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    Yolanda Cifuentes C

    2010-12-01

    Full Text Available Los defectos del ciclo de la úrea se deben a deficiencias de diferentes enzimas; las manifestaciones clínicas son similares y están relacionadas con la hiperamonemia. Se presentan las historias clínicas de tres neonatos a término, sin evidencia de alteración al nacimiento. Se les detectó hiperamonemia y se sospechó enfermedad metabólica. La cromatografía de aminoácidos sugirió defectos del ciclo de la úrea. El manejo incluyó dieta con restricción de proteínas, administración de benzoato de sodio, exsanguinotransfusión y diálisis peritoneal pese a lo cual fallecieron. Se revisan las causas de hiperamonemia en el neonato y se propone una secuencia para su diagnósticoThe urea cycle disorders result from deficiency of activity of enzymes N-acetyl glutamate synthetase, carbamyl phosphate synthase, ornithine transcarbamylase, argininosuccinic acid synthetase, argininosuccinic acid lyase and arginase. Except for the last one, the clinical features are similar and related with the hiperammonaemia. It reports three full term, newborn cases, they had encephalopathy and needed respiratory support after be well in neonatal period. They had hyperammonemia as inborn error. The thin layer amino acids chromatography showed alanine and glutamine, in the siblings appeared citruline, suggesting urea cycle disorders. Despite protein restriction diet, sodium benzoate administration, blood exchange and peritoneal dialysis,babies died. High argininosuccinic acid levels in the first case and high citrulline levels with argininosuccinic acid absence in the third case, which was diagnosed as argininosuccinic aciduria with citrullinemia. This report provide an overview of neonatal hyperammonemia causes and propose a secuency for diagnosis

  16. Cervical celullitis in broiler chickens for Escherichia coli/ Celulite cervical em frangos de corte causada por Escherichia coli

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    Ivens Gomes Guimarães

    2002-05-01

    Full Text Available In this paper was report the isolation of Escherichia coli in broiler chickens with cellulitis in the cervical region. It was carried through the isolation of E. coli of the lesion of cellulitis from broilers and carried through histopathological examination of skin that had characterized the lesion. Focal ulcerations of epidermis, fibrin in dermis and difuse infiltrated by lymphocytes and heterophils on subcutaneous tissues.Neste trabalho, relata-se o isolamento de Escherichia coli em frangos de corte apresentando lesão de celulite na região cervical. Foi realizado o isolamento de E. coli da lesão de celulite e realizado exames histopatológicos que caracterizaram a lesão. Na epiderme foram verificadas lesões ulcerativas, presença de fibrina na derme e infiltração difusa de linfócitos e heterófilos no tecido subcutâneo.

  17. Características laboratoriais das ceratites e conjuntivites causadas por Streptococcus sp Laboratorial findings of Streptococcus keratitis and conjunctivitis

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    Helena Parente Solari

    2004-10-01

    Full Text Available OBJETIVOS: Analisar os resultados laboratoriais de conjuntivites e ceratites com cultura positiva para Streptococcus sp, avaliando a incidência das diferentes espécies e os dados dos antibiogramas. MÉTODOS: Estudo retrospectivo de revisão de prontuários de pacientes encaminhados ao laboratório de Doenças Externas do Departamento de Oftalmologia da UNIFESP com resultado de cultivo bacteriano positivo de córnea ou conjuntiva e com identificação de alguma cepa do gênero Streptococcus sp, no período de janeiro de 1995 a dezembro de 2001. Analisou-se idade do paciente, espécie de Streptococcus e os testes de sensibilidade aos seguintes antibióticos: cefalotina, amicacina, gentamicina, tobramicina, ciprofloxacina, lomefloxacina, ofloxacina, norfloxacina e vancomicina. RESULTADOS: As espécies mais encontradas foram Streptococcus pneumoniae e Streptococcus viridans. Com relação aos antibióticos, a sensibilidade foi maior à cefalotina, às quinolonas e à vancomicina. CONCLUSÕES: Considerando-se os antibióticos tópicos comercialmente disponíveis, as quinolonas apresentam melhor espectro de ação quando comparadas aos aminoglicosídios.PURPOSE: To evaluate laboratorial findings of Streptococcus keratitis and conjunctivitis, analyzing the different species and the results of bacterial susceptibility to an antibiotics. METHODS: Retrospective study of the records from the External Disease Laboratory of the Ophthalmology Department of the Federal University of São Paulo, with conjunctival or corneal positive bacterial culture for Streptococcus sp, between January 1995 and December 2001. The collected data were age, Streptococcus species and the bacterial susceptibility to the following antibiotics: cephalotin, amikacin, gentamicin, tobramicin, ciprofloxacin, lomefloxacin, ofloxacin, norfloxacin and vancomicin. RESULTS: The most frequent species were Streptococcus pneumoniae and Streptococcus viridans. Regarding bacterial susceptibility to antibiotics we found a higher susceptibility to the following antibiotics: cephalotin, quinolones and vancomicin. CONCLUSIONS: Considering the commercially available topic antibiotics, the quinolones presented better results when compared to the aminoglycosides.

  18. Experimental encephalitis caused by Taenia crassiceps cysticerci in mice Encefalite experimental causada por cisticercos de Taenia crassiceps em camundongos

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    Hidelberto Matos-Silva

    2012-04-01

    Full Text Available OBJECTIVES: To present the experimental model of neurocysticercosis (NCC caused by Taenia crassiceps cysticerci, to describe the inflammatory process, susceptibility, or resistance of BALB/c and C57BL/6 mice to this infection, and to describe the host-parasite relationship. METHODS: The animals were intracranially inoculated with initial stage T. crassiceps cysticerci. They were euthanized at 7, 30, 60, and 90 days after the inoculation. Their encephala were removed for the histopathologic analysis, classification of the parasites, and inflammatory lesions. RESULTS: Experimental NCC was observed on both mice lineages. BALB/c mice presented inflammatory lesions with greater intensity, inducing necrosis on late stage parasites, and with an acute inflammation pattern, while C57BL/6 mice showed greater capability on provoking early necrosis in the cysticerci, which showed a chronic inflammation pattern. CONCLUSIONS: This experimental model induced NCC on mice with characteristic inflammation and lesions. C57BL/6 mice were able to induce precocious necrosis of the parasites presenting inflammatory lesions with lower intensity.OBJETIVOS: Apresentar o modelo experimental de neurocisticercose (NCC com cisticercos de Taenia crassiceps, descrever a inflamação, suscetibilidade e resistência em camundongos BALB/c e C57BL/6, caracterizando melhor a relação parasito-hospedeiro. MÉTODOS: Os animais foram inoculados intracranialmente com cisticercos de T. crassiceps em estádio inicial e eutanasiados aos 7, 30, 60 e 90 dias após a infecção. Retiraram-se os encéfalos para análise histopatológica, classificação dos parasitos e lesões inflamatórias. RESULTADOS: Foi possível induzir NCC nas duas linhagens de camundongos utilizados como modelo experimental. Os animais BALB/c apresentaram lesões inflamatórias mais intensas do que os camundongos C57BL/6 e induziram nos parasitos necrose na fase tardia com padrão inflamatório agudo. Os C57BL/6 mostraram-se mais hábeis em provocar necrose precocemente nos cisticercos, mas com padrão inflamatório crônico. CONCLUSÕES: Este modelo experimental induziu NCC nos animais com inflamações e lesões. Os camundongos C57BL/6 foram hábeis em induzir precocemente necrose nos parasitos, apresentando lesões inflamatórias com menor intensidade.

  19. Lesiones causadas por helmintos del aparato digestivo en peces estuarinos de la Laguna Tres Palos, Guerrero, México

    OpenAIRE

    Ramón Vázquez Núñez; José Ramírez Lezama; David Osorio Sarabia; Larisa Adriana Chávez Soriano; Fernando Constantino Casas

    2004-01-01

    Se realizó el presente estudio con el fi n de identificar y comparar las lesiones macro y microscópicas asociadas a helmintos en el tracto digestivo del Ariopsis guatemalensis (“cuatete”) y Eleotris picta (“alahuate”) de la Laguna de Tres Palos, Guerrero, México. En Mayo, Julio y Diciembre del 2001 se colectaron 30 peces de cada especie. A 15 individuos de cada muestra se les practicó el examen histopatológico y a los 15 restantes el examen parasitológico. Se identifi caron tres grupos de hel...

  20. Caracterização de infeções nosocomiais causadas por bactérias resistentes

    OpenAIRE

    Silva, Inês Madail Marques e

    2016-01-01

    As Infeções Nosocomiais são um grave problema de saúde a nível mundial, produzindo endemias e epidemias. O elevado consumo de antibióticos e a transmissão microbiana das resistências nos hospitais são as principais causas do seu aparecimento, sobretudo em Unidades de Cuidados Intensivos. A transmissão de resistências nos hospitais tem levado ao aparecimento de estirpes bacterianas multirresistentes cujo tratamento é dificultado pela falta de recursos terapêuticos, o que resulta em aumento dos...

  1. Técnica de correção de hipernasalidade causada por adenoidectomia Management of hipernasality caused by adenoidectomy

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    Patrícia Junqueira

    2002-08-01

    Full Text Available A tonsila faríngea quando aumentada, pode causar obstrução nas vias aéreas superiores e levar à respiração bucal de suplência¹. Em alguns casos adenoidectomia e/ou adenoamigdalectomia são indicadas para remoção do fator obstrutivo, possibilitando a respiração nasal. Temos observado que algumas crianças mesmo sem apresentar queixas e/ou alterações vocais no período pré-operatório, desenvolvem uma qualidade vocal hipernasal após adenoidectomia12. Este artigo tem como objetivo descrever um caso de hipernasalidade após adenoidectomia e relatar o tratamento fonoaudiológico, bem como, os possíveis riscos e seqüelas após o procedimento cirúrgico.Hipertrophic adenoid is a frequent cause of obstruction of the upper respiratory tract and may lead to a mouth breathing condition. in some cases, surgical procedures such as adenoidectomy and or tonsillectomy are necessary to reestablish the nasal breathing. We have observed that following adenoidectomy, many children present with vocal hipernasality, even when there is no previous history or complains. In this paper, the authors describe a case of severe hipernasality following adenoidectomy, as well as detailed steps of the speech therapy approach. The risks and sequelae of this vocal condition related to adenoidectomy are also discussed.

  2. Meningoradiculitis due to Cryptococcus neofermans in an immunocompetent patient Meningorradiculite lombossacra causada por Cryptococcus neoformans em paciente imunocompetente

    OpenAIRE

    Leonardo Deus-Silva; Costa,Alexandre E.; Juliano M. Bevilacqua; Assis,Denise B.; Ferraz Jr.,Carlos A.; Oliveira, Augusto C P; Anamarli Nucci

    2004-01-01

    Meningoradiculitis refers to combined involvement of meninges and nerve roots. The most frequent location is the lumbosacral region. Etiology is diverse, including inflammatory, infectious and neoplastic disorders. Meningoradiculitis is a rare form of involvement in cryptococcal infection. We describe a case of subacute lower limbs flaccid paresis diagnosed as lumbosacral meningoradiculitis in view of cerebrospinal fluid (CSF) inflammatory changes and typical enhancement on MRI of lumbar spin...

  3. "O corpo que eu fui e o corpo que eu sou": concepções de mulheres com alterações causadas pela hanseníase

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    Iací Proença Palmeira

    2012-01-01

    Full Text Available Se objetivó comprender las concepciones de las mujeres sobre el cuerpo femenino con alteraciones provocadas por la lepra. Estudio de naturaleza cualitativa y descriptiva, que aplicó los conceptos de la teoría de las representaciones. Participaron cuarenta y tres mujeres con alteraciones corporales causadas por la lepra, frecuentadoras de una unidad de referencia especializada en dermatología sanitaria. Se realizó entrevista semi-estructurada, individual, y análisis temático de contenido. Los resultados muestran concepciones del cuerpo relacionadas a la salud (pasado y a la enfermedad (presente, mostrando la fuerza de la estética y la funcionalidad del cuerpo, influenciando en la participación e inserción social de estas mujeres. Se concluye que las concepciones de las mujeres sobre su cuerpo explican sus prácticas de cuidado de sí, y conocerlas contribuye para que enfermería mejore la atención de las necesidades de estas mujeres.

  4. Blau Syndrome-Related CARD15/NOD2 Mutations Are Not Linked to Idiopathic Uveitis in Spanish Patients

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    Noelia Rodríguez-Pérez

    2009-01-01

    Full Text Available Uveitis is a clinical feature of the Blau syndrome, a disease linked to CARD15 (also referred to as NOD2 mutations. Three main mutations in this gene (R334W, R334Q and L469F have been reported as Blau syndrome risk factors, a disease that manifests uveitis as one of its clinical features. However, little is known on the involvement of this gene in idiopathic uveitis. We thus sought to determine the frequency of these Blau-related CARD15 mutations in a cohort of Spanish patients with idiopathic uveitis. To this aim, 110 patients with idiopathic uveitis, followed at the Department of Ophtalmology of a tertiary hospital (Hospital Universitario Alcalá de Henares, Madrid. Spain were enrolled. As a control population, 104 healthy subjects were used. DNA was extracted from blood samples and the Blau-related CARD15 mutations were analysed either by PCR-RFLP or direct DNA sequencing. None of the mutations studied was found in any of the individuals tested, whether diseased or healthy. It seems thus that Blau syndrome-related CARD15 mutations are not involved in idiopathic uveitis, a finding which allows us to suggest that the genetic aetiology of the idiopathic uveitis or the Blau-associated uveitis is different.

  5. Supramolecular nanofibers of triamcinolone acetonide for uveitis therapy

    Science.gov (United States)

    Li, Xingyi; Wang, Yuqin; Yang, Chengbiao; Shi, Shuai; Jin, Ling; Luo, Zichao; Yu, Jing; Zhang, Zhaoliang; Yang, Zhimou; Chen, Hao

    2014-11-01

    Supramolecular nanofibers of prodrugs hold advantages for drug release due to their high drug payload, sustained and constant drug release behavior, and stimuli responsiveness. In this study, we report on a supramolecular hydrogel mainly formed by a clinically used drug triamcinolone acetonide (TA). Such a hydrogel could only be prepared via an ester bond hydrolysis process from its prodrug of succinated triamcinolone acetonide (STA). The resulting hydrogel could constantly release TA in the in vitro release experiment. The TA hydrogel possessed an excellent transscleral penetration ability, as evaluated by the in vitro transscleral transport study. The developed TA hydrogel also exhibited a great ocular compatibility in rats, as indicated by the optical coherence tomography (OCT) images, HE observation, and glial fibrillary acidic protein (GFAP) and vimentin immuno-staining assays of the retinas. Our TA hydrogel showed a decreased efficacy to inhibit ocular inflammation in the rat's experiment autoimmune uveitis (EAU) model compared to the commercial TA suspension (Transton®), but without causing complications such as high intraocular pressure and cataracts. These promising properties of the hydrogel indicated its great potential for the treatment of eye diseases.Supramolecular nanofibers of prodrugs hold advantages for drug release due to their high drug payload, sustained and constant drug release behavior, and stimuli responsiveness. In this study, we report on a supramolecular hydrogel mainly formed by a clinically used drug triamcinolone acetonide (TA). Such a hydrogel could only be prepared via an ester bond hydrolysis process from its prodrug of succinated triamcinolone acetonide (STA). The resulting hydrogel could constantly release TA in the in vitro release experiment. The TA hydrogel possessed an excellent transscleral penetration ability, as evaluated by the in vitro transscleral transport study. The developed TA hydrogel also exhibited a great ocular

  6. Acute Tubulointerstitial Nephritis and Anterior Uveitis (TINU Syndrome: A Report of Two Cases

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    Mortajil Fatima

    2006-01-01

    Full Text Available TINU or Dobrin syndrome is a rare oculo-renal inflammatory condition which is comprised of acute idiopathic tubulointerstitial nephritis and uveitis. We report here two female patients aged 35 and 44 years, who were admitted with severe renal failure of acute onset (serum creatinine of 607 and 310 Umol/L [Editor note: do you mean "µmol/L"?] respectively with the first patient requiring hemodialysis. The cause of acute renal failure was unclear on clinical and laboratory assessment, and a percutaneous renal biopsy was performed which showed features of acute tubulointerstitial nephritis in both cases. Both patients were started on oral steroids at a dose of 1 mg/kg/day. There was progressive improvement of their renal function. Three months later, the two patients presented with bilateral anterior uveitis requiring local corticosteroid therapy. This was followed by total resolution of the uveitis. The cause of the interstitial nephritis and the uveitis could not be identified in the two cases. The renal function was normal in these patients after 24 and 27 months of follow-up, respectively. Dobrin or TINU syndrome is rare, and must be considered in patients who present with acute tubular interstitial [Editor note: for consistency with the title, you may wish to replace this with "tubulointerstitial"] nephritis and anterior uveitis.

  7. Cytokines and Biologics in non-infectious autoimmune uveitis: Bench to Bedside

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    Rupesh Agrawal

    2014-01-01

    Full Text Available Intraocular inflammatory eye disease is one of the important causes of ocular morbidity. Even though the prevalence of uveitis is less common in relation to diabetic retinopathy, glaucoma or age related macular degeneration, the complexity and heterogeneity of the disease makes it more unique. Putative uveitogenic retinal antigens incite innate immunity by the process of antigen mimicry and have been shown to be associated in patients with intraocular inflammatory disease by numerous experimental studies. Laboratory diagnostic tools to aid the etiologic association in intraocular inflammatory disease have evolved over the last two decades and we are entering into an era of molecular diagnostic tests. Sophisticated novel technologies such as multiplex bead assays to assess biological signatures have revolutionized the management of complex refractory uveitis. Nevertheless, there is still a long way to go to establish the causal relationship between these biomarkers and specific uveitic entities. Experimental studies have shown the supreme role of infliximab in the management of Behcet′s disease. Despite significant experimental and case control studies, the deficiency of randomized clinical trials using these biologic agents has handicapped us in exploring them as a front line therapy in severe refractory uveitis. Studies still need to answer the safety of these potentially life threatening drugs in a selected group of patients and determine when to commence and for how long the treatment has to be given. This review article covers some basic concepts of cytokines in uveitis and their potential application for therapy in refractory uveitis.

  8. Characterization of rat model of acute anterior uveitis using optical coherence tomography angiography

    Science.gov (United States)

    Choi, Woo June; Pepple, Kathryn L.; Zhi, Zhongwei; Wang, Ruikang K.

    2015-03-01

    Uveitis, or ocular inflammation, is a cause of severe visual impairment. Rodent models of uveitis are powerful tools used to investigate the pathological mechanisms of ocular inflammation and to study the efficacy of new therapies prior to human testing. In this paper, we report the utility of spectral-domain optical coherence tomography (SD-OCT) angiography in characterizing the inflammatory changes induced in the anterior segment of a rat model of uveitis. Acute anterior uveitis (AAU) was induced in two rats by intravitreal injection of a killed mycobacterial extract. One of them received a concurrent periocular injection of steroids to model a treatment effect. OCT imaging was performed prior to inflammation induction on day 0 (baseline), and 2 days post-injection (peak inflammation). Baseline and inflamed images were compared. OCT angiography identified swelling of the cornea, inflammatory cells in the anterior and posterior chambers, a fibrinous papillary membrane, and dilation of iris vessels in the inflamed eyes when compared to baseline images. Steroid treatment was shown to prevent the changes associated with inflammation. This is a novel application of anterior OCT imaging in animal models of uveitis, and provides a high resolution, in vivo assay for detecting and quantifying ocular inflammation and the response to new therapies.

  9. UVEITIS INA RHEUMATOLOGISTS PRACTICE: A ROLE OF TUMOR NECROSIS FACTOR-а INHIBITORS

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    Sergey Valentinovich Moiseyev

    2009-01-01

    Full Text Available Uveitis frequently develops in patients with ankylosing spondylitis (AS and other autoimmune diseases. It is occasionally characterized by a severe recurrent course and untreatable with systemic glucocorticoids (GC and standard immunosuppressive agents. The results of (mainly small clinical trials, as well as some observations suggest that therapy with tumor necrosis factor-а (TNF-а inhibitors is effective in such patients. There is the strongest evidence that they are beneficial in treating recurrent uveitis in patients with AS, infliximab having some efficacy advantages over etanercept and adalimumab. Accordingly, chronic uveitis in AS can be considered as an additional argument in favor of the use of TNF-а inhibitors. Furthermore, treatment with drugs of this group is warranted in severe uveitis refractory to GC and immunosuppressants. It is conceivable that in some forms of uveitis, for example, in patients with Behcet's disease, treatment with TNF-а inhibitors should be initiated at an earlier stage as the efficacy of standard immunosuppressants is generally limited

  10. Tubulointerstitial Nephritis and Uveitis Syndrome in an Elderly Man: Case Report and Literature Review.

    Science.gov (United States)

    Lei, Wen-Hui; Xin, Jun; Yu, Xue-Ping; Li, Jie; Mao, Ming-Feng; Ji, Jian-Song; Wu, Chui-Fen; Zhu, Chao-Yong; Jin, Lie

    2015-11-01

    Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease of unknown etiology defined by the combination of tubulointerstitial nephritis, uveitis, and biochemical abnormalities. It has been reported that TINU mainly affects adolescents and young women. Here we reported a special case regarding a 60-year-old man with acute renal failure due to TINU syndrome documented by renal biopsy.We present a rare case of an elderly patient, who had been suffering from a fever for 2 weeks, characterized by sudden onset and resolving spontaneously, and accompanied by extreme fatigue, loss of appetite, and shivering. Renal biopsy showed a tubulointerstitial nephritis, with polymorphonuclear infiltration and acute tubulitis. In the outpatient clinic, he was diagnosed with idiopathic bilateral anterior uveitis 1 month ago. Ophthalmological examination revealed anterior asymptomatic bilateral uveitis. Human leukocyte antigen (HLA) typing (HLA-DQA1*0101/0201 and HLA-DQB1*0303/0503) was found which supported the suspect of TINU syndrome. The patient was treated with oral prednisone (1 mg/kg) and continued for 8 weeks on tapering doses. Serum creatinine normalized within 3 and 6 months later renal function also recovered completely.This case highlights that TINU syndrome is probably an underdiagnosed disease responsible for some cases of idiopathic anterior uveitis in elderly male patients. It is of critical importance to be aware of this syndrome by nephrologist and ophthalmologists in this special population. Further studies are needed to elucidate clinical characteristic and pathogenesis of TINU syndrome in elderly population.

  11. Refractory Uveitis in Patient with Castleman Disease Successfully Treated with Tocilizumab

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    Toshiyuki Oshitari

    2012-01-01

    Full Text Available Although multicentric Castleman disease is a rare but life-threatening disease, eye complications are extremely uncommon. We present a case of refractory uveitis accompanied with Castleman disease successfully treated with tocilizumab. A 58-year-old man with Castleman disease was introduced for refractory uveitis to Chiba University Hospital. Large cells were detected in the anterior chamber and increased vascular permeability of retinal vessels has been found in both eyes. Although the patient was treated with oral and eye drop steroid treatment, the uveitis symptoms had not decreased. The serum levels of CRP and IL-6 were increased. The level of IL-6 concentration in the anterior chamber was the same as the serum level of IL-6. The humanized anti-IL-6 receptor-antibody (tocilizumab was administrated for the patient because of poor general condition. After tocilizumab treatment, large cells in the anterior chamber were undetectable and vascular permeability was improved in FA. The serum levels of CRP and IL-6 decreased and the general condition improved. The side effect of tocilizumab was not observed during the treatment. Tocilizumab treatment was significantly effective for uveitis accompanied with Castleman disease. Although it is extremely rare, uveitis accompanied with Castleman disease may be one of the hallmarks to consider tocilizumab treatment.

  12. [Clinical features of uveitis in childhood during the past 20 years].

    Science.gov (United States)

    Fujioka, S; Nakagawa, Y; Tada, R; Ohji, M; Hara, Y; Hagihara, M; Fujii, S; Haruta, Y; Yuasa, T

    1990-08-01

    One hundred and fifty five cases (237 eyes) of children with uveitis were clinically observed in the past 20 years. There was no fluctuation in the number of patients during the period. Concerning the age as the first visit, the smallest group was under 4 years of age and the numbers of patients increased at ages 14 and 15. Chief complaints usually corresponded to the age of the cases. Cases with anterior uveitis accounted for 25% of all cases, intermediate uveitis 12%, posterior uveitis 45% and panuveitis consisted of 17% of all cases, respectively. In the course of treatment, improvement of visual acuity was not statistically significant; the visual prognosis of cases affected under age 7 years was relatively poor. At the time of final observation, the visual acuity of cases, who had first visited during the past 10 years, were better than those who presented during the previous decade. Uveitis had healed or improved in 68% of cases treated in our clinic. As complications, band-shaped keratopathy was seen in 8% of the patients, cataract in 22% and glaucoma in 5%, respectively. Thirty two per cent of the cases received systemic steroid therapy and the average duration was 3.8 months. Fifty two operations were performed in 30 cases (19%), 37 eyes (16%); 16 were cataract operations and 24 were operations for glaucoma.

  13. [Effect of melatonin instillations on the clinical course of experimental uveitis and biochemical processes in tears and aqueous humor].

    Science.gov (United States)

    Chesnokova, N B; Beznos, O V; Lozinskaya, N A; Beyshenova, G A; Nesterova, T V

    2016-01-01

    Acute immunogenic uveitis was modeled in rabbits via the subcutaneous and intravitreal injections of normal horse serum. We studied the effect of instillations of 0.1% melatonin solution on the clinical course of uveitis and biochemical parameters of tear fluid and aqueous humor: antioxi-dant activity, protein concentration and α(2)-macroglobulin level. Melatonin instillations decreased clinical manifestations of uveitis. We found that the antioxidant activity in tears of the rabbits treated with melatonin was substantially higher and the α(2)-macroglobulin level lower than in untreated animals. Antioxidant activity in aqueous humor taken on day 10 of uveitis was also twice higher while protein and α(2)-macroglobulin levels were 1.5-2 times lower than in untreated animals. These data indicate that instillations of melatonin increase the local antioxidant activity and decrease the acuity of inflammation and permeability of hematoophthalmic barrier in uveitis.

  14. Chronic Refractory Uveitis in a Patient with Childhood-Onset Cyclic Neutropenia

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    Li-Li Chen

    2011-05-01

    Full Text Available We report a rare case of chronic refractory uveitis in a patient with childhood-onset cyclic neutropenia (CN. A 19-year-old woman, who had a history of CN beginning at age 2, presented with bilateral chronic nongranulomatous uveitis, complicated cataract, retinal vasculitis, cystoids macular edema, and vitreous hemorrhage. She had recurrent episodes of oral ulcers, tonsillitis, genital ulcers, and folliculitis during neutropenic nadir. After the resumption of granulocyte colony-stimulating factor therapy for her CN, vitreous hemorrhage in both eyes followed. Her eyes were treated with topical corticosteroids, retinal photocoagulation, and cataract surgery. Blood and bone marrow test results confirmed the diagnosis of CN. She also fulfilled the diagnostic criteria of Behçet’s disease, though clinical features of her uveitis were dissimilar to those found in that disease.

  15. Scintigraphy of sacroliac joints in acute anterior uveitis. A study of thirty patients

    Energy Technology Data Exchange (ETDEWEB)

    Russell, A.S.; Lentle, B.C.; Percy, J.S.; Jackson, F.I.

    1976-11-01

    HLA-B27 is a transplantation antigen found in a high proportion of patients with ankylosing spondylitis. Recently, an association has been shown to exist between HLA-B27 and acute uveitis, even in the absence of ankylosing spondylitis. We have examined the HLA antigen profile of 45 patients with acute nongranulomatous anterior uveitis and have confirmed this relation. In addition, using 90m technetium stannous pyrophosphate we have been able to demonstrate abnormal bone scan in 19 of 30 patients studied. Such abnormalities are limited to the sacroiliac joints but are otherwise the same as those seen in overt ankylosing spondylitis. Seven of the 19 patients did not have HLA-B27. These factors suggest that acute anterior uveitis may often represent a manifestation of a spondylitic diathesis even in the complete absence of any suggestive symptomatic or radiologic change and, in some cases, even through the antigenic marker HLA-B27 may be absent.

  16. Scintigraphy of sacroiliac joints in acute anterior uveitis. A study of thirty patients.

    Science.gov (United States)

    Russell, A S; Lentle, B C; Percy, J S; Jackson, F I

    1976-11-01

    HLA-B27 is a transplantation antigen found in a high proportion of patients with ankylosing spondylitis. Recently, an association has been shown to exist between HLA-B27 and acute uveitis, even in the absence of ankylosing spondylitis. We have examined the HLA antigen profile of 45 patients with acute nongranulomatous anterior uveitis and have confirmed this relation. In addition, using 90mtechnetium stannous pyrophosphate we have been able to demonstrate abnormal bone scan in 19 of 30 patients studied. Such abnormalities are limited to the sacroiliac joints but are otherwise the same as those seen in overt ankylosing spondylitis. Seven of the 19 patients did not have HLA-B27. These factors suggest that acute anterior uveitis may often represent a manifestation of a spondylitic diathesis even in the complete absence of any suggestive symptomatic or radiologic change and, in some cases, even though the antigenic marker HLA-B27 may be absent.

  17. A proteomic approach for studying the pathogenesis of spontaneous equine recurrent uveitis (ERU).

    Science.gov (United States)

    Deeg, Cornelia A

    2009-03-15

    Equine recurrent uveitis (ERU) is a wide spread disease of the eye, which is the main cause for blindness in horses worldwide. Meanwhile, ERU is also accepted as the only reliable spontaneous model for human autoimmune uveitis. We identified and characterized novel autoantigens by analyzing the autoantibody-binding pattern from ERU cases to the retinal proteome. Cellular retinaldehyde-binding protein (CRALBP) and malate dehydrogenase (MDH) were detected as novel ERU autoantigens by this approach. B- and T-cell autoreactivity was detected to both autoantigens in ERU cases. The evaluation of the pathological relevance of CRALBP and MDH brought surprising results. While CRALBP-induced uveitis with high incidence in rats and horses, MDH was only uveitogenic in Lewis rats, but not in the horse itself.

  18. A review and update on orphan drugs for the treatment of noninfectious uveitis

    Directory of Open Access Journals (Sweden)

    You C

    2017-01-01

    Full Text Available Caiyun You,1–3 Haitham F Sahawneh,1,2 Lina Ma,1,2 Buraa Kubaisi,1,2 Alexander Schmidt,1,2 C Stephen Foster1,2,4 1Massachusetts Eye Research and Surgery Institution (MERSI, Waltham, 2Ocular Immunology and Uveitis Foundation, Weston, MA, USA; 3Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 4Harvard Medical School, Boston, MA, USA Introduction: Uveitis, a leading cause of preventable blindness around the world, is a critically underserved disease in regard to the medications approved for use. Multiple immunomodulatory therapy (IMT drugs are appropriate for uveitis therapy but are still off-label. These IMT agents, including antimetabolites, calcineurin inhibitors, alkylating agents, and biologic agents, have been designated as “orphan drugs” and are widely used for systemic autoimmune diseases or organ transplantation.Area covered: The purpose of this paper is to comprehensively review and summarize the approved orphan drugs and biologics that are being used to treat systemic diseases and to discuss drugs that have not yet received approval as an “orphan drug for treating uveitis” by the US Food and Drug Administration (FDA.Our perspective: IMT, as a steroid-sparing agent for uveitis patients, has shown promising clinical results. Refractory and recurrent uveitis requires combination IMT agents. IMT is continued for a period of 2 years while the patient is in remission before considering tapering medication. Our current goals include developing further assessments regarding the efficacy, optimal dose, and safety in efforts to achieve FDA approval for “on-label” use of current IMT agents and biologics more quickly and to facilitate insurance coverage and expand access to the products for this orphan disease. Keywords: immunomodulatory, orphan drug, steroid sparing, uveitis

  19. A Case of Syphilitic Uveitis in Which Vitreous Surgery Was Useful for the Diagnosis and Treatment

    Science.gov (United States)

    Kobayashi, Takatoshi; Katsumura, Chihiro; Shoda, Hiromi; Takai, Nanae; Takeda, Sayako; Okamoto, Takako; Maruyama, Koichi; Tada, Rei; Tajiri, Kensuke; Kida, Teruyo; Ikeda, Tsunehiko

    2017-01-01

    Purpose To report a case of atypical syphilitic uveitis complicated with retinal vasculitis, proliferative retinopathy, and vitreous hemorrhage in which vitreous surgery was useful for the diagnosis and treatment. Case Report A 38-year-old female was referred to our hospital after noticing visual disturbance in her right eye. Fundoscopy examination of that eye revealed retinal phlebitis accompanied by retinal hemorrhage and soft exudate, and remarkable exudative changes in the retinal vessels from the upper arcade to the macula region. After a blood examination, a serological test showed positive for syphilis; however, systemic findings were scarce. Syphilitic uveitis was suspected, so we administered treatment for syphilis, anticoagulant treatment for retinal vasculitis, steroids for intraocular inflammation, and photocoagulation for the retinal nonperfusion area. However, her visual acuity (VA) decreased to 30 cm/counting fingers due to vitreous hemorrhage resulting from fibrovascular membrane at the optic disc. Since the vitreous hemorrhage was insufficiently absorbed, vitreous surgery was performed to remove the hemorrhage and fibrovascular tissue. Following surgery, the uveitis and retinal vasculitis subsided, and her corrected VA improved to 0.3. Postoperative examination of a fixed quantity of collected vitreous fluid for syphilis showed a Treponema pallidum hemagglutination value of 5,120 times the normal amount, thus confirming the syphilitic uveitis diagnosis. Conclusions Our findings show that when observing patients with obstructive retinal vasculitis of unknown causes, syphilitic uveitis should be considered as a differential diagnosis, and that vitreous surgery is useful for the diagnosis and treatment of atypical syphilitic uveitis which has progressed to proliferative retinopathy. PMID:28203197

  20. Certolizumab-Induced Uveitis: A Case Report and Review of the Literature

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    Elad Moisseiev

    2014-02-01

    Full Text Available We report the case of a 64-year-old woman with rheumatoid arthritis and bilateral visual deterioration. The patient had been treated with certolizumab, a new tumor necrosis factor alpha (TNFα antagonist, and her findings were consistent with bilateral uveitis, suggestive of sarcoidosis. Here, we review the literature on TNFα antagonist-induced sarcoidosis and report the first case of uveitis induced by certolizumab. Awareness of the possibility of this unique complication is important for both rheumatologists and ophthalmologists who treat patients with this new agent.

  1. Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice

    OpenAIRE

    Yao Xin-Sheng; Yao Nan; Lan Fang; Tsoi Bun; He Rong-Rong; Kurihara Hiroshi

    2011-01-01

    Abstract Background Lutein is an important eye-protective nutrient. This study investigates the protective effects and mechanisms of lutein on lipopolysaccharides (LPS)-induced uveitis in mice. Methods Lutein, suspended in drinking water at a final concentration of 12.5 and 25 mg/mL, was administered to mice at 0.1 mL/10 g body weight for five consecutive days. Control and model group received drinking water only. Uveitis was induced by injecting LPS (100 mg per mouse) into the footpad in the...

  2. Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice

    OpenAIRE

    He, Rong-rong; Tsoi, Bun; Lan, Fang; Yao, Nan; Yao, Xin-Sheng; Kurihara, Hiroshi

    2011-01-01

    Background Lutein is an important eye-protective nutrient. This study investigates the protective effects and mechanisms of lutein on lipopolysaccharides (LPS)-induced uveitis in mice. Methods Lutein, suspended in drinking water at a final concentration of 12.5 and 25 mg/mL, was administered to mice at 0.1 mL/10 g body weight for five consecutive days. Control and model group received drinking water only. Uveitis was induced by injecting LPS (100 mg per mouse) into the footpad in the model an...

  3. Enfermedades sistémicas no infecciosas y uveítis Non-infectious systemic diseases and uveitis

    Directory of Open Access Journals (Sweden)

    D. Díaz-Valle

    2008-01-01

    Full Text Available La uveítis se define como la inflamación del tracto uveal, aunque en la práctica clínica hace referencia a cualquier proceso inflamatorio intraocular. El origen de esta inflamación puede atribuirse a un mecanismo endógeno, ya sea formando parte de una enfermedad sistémica (sarcoidosis, enfermedad de Behçet, esclerosis múltiple, síndrome de Vogt-Koyanagi-Harada, etc. o de forma ocular aislada. En muchas ocasiones, la enfermedad ocular constituye la forma de comienzo de una enfermedad sistémica. Por otra parte, la afectación ocular constituye, en ocasiones, la principal causa de morbilidad derivada de la enfermedad, por lo que su diagnóstico y tratamiento precoz son de la máxima importancia para evitar secuelas irreversibles. En este artículo se revisan los aspectos clínicos, diagnósticos y terapéuticos más relevantes de la afectación ocular en el contexto clínico de las enfermedades sistémicas no infecciosas más comúnmente asociadas a uveítis.Uveitis can be defined as any inflammation affecting the uveal tract, although in clinical practice this term includes any intraocular inflammatory event. The etiology of this inflammation can be related to an endogenous mechanism in the clinical course of a systemic disease (sarcoidosis, Behçet’s disease, multiple sclerosis, Vogt-Koyanagi-Harada disease, etc., or an isolated ocular entity. Sometimes, ocular inflammation is the initial manifestation of an undiagnosed systemic disease. On the other hand, ocular involvement could be the main cause of morbidity of the disease, and early diagnosis and treatment is an important issue in order to avoid irreversible ocular damage. In this article, the authors review some relevant clinical, diagnostic and therapeutic topics related to the most common non-infectious systemic diseases associated with uveitis.

  4. Visual impairment from uveitis in a reference hospital of Southeast Brazil: a retrospective review over a twenty years period

    Directory of Open Access Journals (Sweden)

    Luci Meire Pereira da Silva

    2013-12-01

    Full Text Available PURPOSE: To identify the frequency and causes of uveitis leading to visual impairment in patients referred to the Low Vision Service - Department of Ophthalmology - UNIFESP, over a twenty years period. METHODS: In a retrospective study, medical records of 5,461 patients were reviewed. Data from the first clinical evaluation at the Low Vision Service were collected, patient's age, gender and cause of visual impairment were analyzed. Patients with uveitis had their chart reviewed for anatomical classification and clinical diagnosis. RESULTS: The mean age of the patients referred to the Low Vision Service was 42.86 years and the mean age of patients with uveitis diagnosis was 25.51 years. Retinal disorders were the most common cause of visual impairment (N=2,835 patients; 51.9% followed by uveitis (862 patients, 15.7%. Uveitis was posterior in 792 patients (91.9% of uveitis and toxoplasmosis was the most common diagnosis (765 patients, 88.7%. CONCLUSIONS: In our study, uveitis represents the second cause of visual impairment in patients referred for visual rehabilitation and toxoplasmic retinochoroiditis was the most common clinical diagnosis. It affects a young working age population with a relevant social and economic impact, but the early diagnosis and treatment can improve the quality of life of these patients.

  5. Clinical characteristics of intermediate uveitis in adult Turkish patients

    Institute of Scientific and Technical Information of China (English)

    Esra; Kardes; Betul; Ilkay; Sezgin; Akcay; Kansu; Bozkurt; Cihan; Unlu; Gurkan; Erdogan; Gulunay; Akcali

    2015-01-01

    ·AIM: To describe the clinical characteristics of Turkish patients with intermediate uveitis(IU) and to investigate the effect of clinical findings and complications on final visual acuity(VA).·METHODS: We retrospectively analyzed the medical records of patients with IU who had at least 6mo of follow-up and were older than 16 y.· RESULTS: A total of 78 eyes of 45 patients were included in the study and the mean follow-up period was19.4mo. The mean age at the time of presentation was42.9s. Systemic disease associations were found in17.7% of cases; sarcoidosis(8.8%) and multiple sclerosis(6.6%) were the most common diseases. Recurrence rate(odds ratio=45.53; 95%CI: 2.181-950.58), vitritis equals to or more than 3+ cells(odds ratio =57.456; 95%CI: 4.154-794.79) and presenting with VA less than 20/40(odds ratio =43.81; 95% CI: 2.184-878.71) were also found as high risk factors for poor final VA. At the last follow-up examination, 67.9% of eyes had VA of 20/40 or better.·CONCLUSION: IU is frequently seen at the beginning of the fourth decade of life. The disease is most commonly idiopathic in adult Turkish patients. Patients with severe vitritis at presentation and patients with frequent recurrences are at high risk for poor visual outcome.

  6. Immunopathology of recurrent uveitis in spontaneously diseased horses.

    Science.gov (United States)

    Deeg, C A; Ehrenhofer, M; Thurau, S R; Reese, S; Wildner, G; Kaspers, B

    2002-08-01

    Equine recurrent uveitis (ERU) is the most serious eye disease in horses worldwide. Despite the fact that ERU is generally considered to be immune mediated, a detailed description of the histopathology of the posterior part of ERU eyes is lacking. Here, we examined sections of paraffin-embedded eyes using histological and immunhistological methods. Twenty seven eyes of 20 horses with ERU and 30 eyes of 15 healthy control horses were included in this study. We could consistently demonstrate an involvement of the retina and the choroid in all examined eyes of horses with spontaneous ERU. In eyes with minimal histopathological changes, the infiltrates consisted almost exclusively of T-cells. Histopathological changes start with the destruction of the photoreceptor outer segments, which often leads to focal retinal detachment. In more severely affected eyes, there is additional disintegration of the ganglion cell layer and the inner nuclear layer. In almost all examined eyes, lymphoid follicle formation could be demonstrated. Typical localizations of these follicles were the iris stroma and the choroid underneath the transition zone of the retina without photoreceptor cells to the region containing photoreceptor cells. These follicles consist of a T-cell rich periphery with a small center of CD3-negative lymphocytes. In cases with extreme histopathological changes, the retinal architecture is widely disintegrated with massive infiltration of the retina, the choroid, and the ciliary body by several types of inflammatory cells. Necrotic remnants of the retina are end-stage findings and there is only a minor inflammatory infiltration left. This study provides clear evidence that the retina is involved in all stages of ERU. Inflammation is mainly driven by T-cells as T-cells were demonstrated in mild stages of the disease and are also the predominating cell type in all other stages of ERU.

  7. Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up

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    Pia Allegri

    2010-10-01

    Full Text Available Pia Allegri1, Antonio Mastromarino1, Piergiorgio Neri21Uveitis Center, Ophthalmological Department of Lavagna Hospital, Genova, Italy; 2Uveitis Unit, The Eye Clinic, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Ancona, Ancona, ItalyAbstract: Curcumin has been successfully applied to treat inflammatory conditions in experimental research and in clinical trials. The purpose of our study is to evaluate the efficacy of an adjunctive-to-traditional treatment with Norflo tablets (curcumin-phosphatidylcholine complex; Meriva administered twice a day in recurrent anterior uveitis of different etiologies. The study group consisted of 106 patients who completed a 12-month follow-up therapeutic period. We divided the patients into three main groups of different uveitis origin: group 1 (autoimmune uveitis, group 2 (herpetic uveitis, and group 3 (different etiologies of uveitis. The primary end point of our work was the evaluation of relapses frequency in all treated patients, before and after Norflo treatment, followed by the number of relapse in the three etiological groups. Wilcoxon signed-rank test showed a P < 0.001 in all groups. The secondary end points were the evaluation of relapse severity and of the overall quality of life. The results showed that Norflo was well tolerated and could reduce eye discomfort symptoms and signs after a few weeks of treatment in more than 80% of patients. In conclusion, our study is the first to report the potential therapeutic role of curcumin and its efficacy in eye relapsing diseases, such as anterior uveitis, and points out other promising curcumin-related benefits in eye inflammatory and degenerative conditions, such as dry eye, maculopathy, glaucoma, and diabetic retinopathy.Keywords: curcumin, anterior recurrent uveitis, phosphatidylcholine-bound-curcumin (Meriva

  8. Pneumonia grave por "Chlamydia psittaci"

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    MOSCHIONI CRISTIANE

    2001-01-01

    Full Text Available A psitacose, também conhecida como ornitose, é causada pela Chlamydia psittaci; caracteriza-se por doença de início insidioso, sintomas brandos e inespecíficos, lembrando infecção de vias aéreas superiores. Acomete principalmente o pulmão, sendo raramente doença sistêmica e fatal. Descreve-se um caso raro de pneumonia por Chlamydia psittaci que evoluiu para insuficiência respiratória aguda, necessitando de ventilação mecânica. Destaca-se a importância em considerar o diagnóstico, especialmente em casos de pneumonia comunitária que evolui de modo insatisfatório, que não responde à terapia antimicrobiana e cuja epidemiologia é positiva para exposição às aves. O diagnóstico precoce é fundamental devido à excelente resposta terapêutica. O diagnóstico tardio pode levar a curso grave e fatal da doença.

  9. Rabdomiólisis aguda masiva secundaria a neumonía con bacteriemia por Moraxella catarrhalis

    OpenAIRE

    Fajardo, Miguel; Vergara, Esther; Hernández-Blázquez, Antonia; Hernández-Rastrollo, Ramón

    2014-01-01

    Moraxella catarrhalis es una bacteria implicada en infecciones respiratorias, otitis, sinusitis, mastoiditis o conjuntivitis. Menos frecuente es su participación en bacteriemias y artritis, siendo éste el primer caso descrito de rabdomiolisis (RM) aguda difusa. La RM aguda difusa de etiología infecciosa generalmente está causada por virus, seguido de bacterias con un conocido poder patógeno, como Streptococcus pneumoniae, Mycoplasma pneumoniae o Legionella pneumophyla. Se diagnostica por la p...

  10. A correlation of pregnancy term, disease activity, serum female hormones, and cytokines in uveitis

    OpenAIRE

    Chan, C-C; Reed, G F; Kim, Y.; Agrón, E; Buggage, R R

    2004-01-01

    Background/aims: Pregnancy and the postpartum period are associated with the activity of autoimmune diseases including uveitis. Although the exact mechanism is unknown, hormones are reported to alter inflammatory cytokines and influence disease activity. The authors studied ocular inflammation, female hormones, and serum cytokine levels during and after pregnancy.

  11. Anterior Uveitis Caused by Ocular Side Effects of Afatinib: A Case Report.

    Science.gov (United States)

    Todokoro, Daisuke; Itakura, Hirotaka; Ibe, Takashi; Kishi, Shoji

    2016-01-01

    Afatinib is a second-generation epidermal growth factor receptor (EGFR) inhibitor that has been shown to be effective against EGFR-mutated non-small cell lung cancer (NSCLC) resistant to conventional EGFR inhibitors such as gefitinib and erlotinib. Although ocular side effects of gefitinib and erlotinib have been reported, those for afatinib have yet to be definitively established. This report presents details on the first case of unilateral iridocyclitis associated with the side effects of afatinib therapy. A 75-year-old Japanese male ex-smoker with EGFR-mutated NSCLC underwent afatinib therapy for multiple metastases. At 2 weeks, bilateral conjunctivitis developed. Topical medication and a 1-week afatinib washout period resulted in the improvement of the conjunctivitis. However, 3 days after the resumption of afatinib, the patient developed unilateral granulomatous anterior uveitis in his right eye. Best-corrected visual acuity (BCVA) measurement indicated a decimal visual acuity of 0.2, while the slit-lamp findings were characterized by granulomatous inflammation, keratic precipitates, Koeppe nodules and posterior synechiae. There was no evidence suggesting other intraocular inflammatory disease or metastatic tumor. The left eye was intact. The use of topical medication including steroids and a washout of afatinib resulted in a gradual subsiding of the anterior uveitis. After resolution of the anterior uveitis, oral afatinib was resumed. BCVA of the right eye finally recovered to a decimal acuity of 1.0. Ophthalmologists should be aware of the possibility that side effects associated with afatinib could cause granulomatous anterior uveitis.

  12. Intermediate Uveitis and Alopecia Areata : Is There a Relationship? Report of 3 Pediatric Cases

    NARCIS (Netherlands)

    Ayuso, Viera Kalinina; Pott, Jan Willem; de Boer, Joke Helena

    2011-01-01

    Three previously healthy children, aged 5, 8, and 15 years, with idiopathic intermediate uveitis (IU) and alopecia areata (AA) are described. These are the first 3 cases of which we are aware with this coexistence. The results of extensive diagnostic evaluations were negative in all 3 cases. AA prec

  13. Coincidence of Varicella-Zoster Virus Anterior Uveitis in a Patient with Chandler's Syndrome

    Directory of Open Access Journals (Sweden)

    Takeshi Joko

    2013-11-01

    Full Text Available Purpose: We report a patient who, based on the clinical manifestations, was originally diagnosed as having Chandler's syndrome and later developed varicella-zoster virus (VZV DNA-positive anterior uveitis. Methods: The patient with Chandler's syndrome who manifested anterior uveitis underwent a complete ophthalmologic examination. Polymerase chain reaction (PCR was used to amplify the viral DNA in the aqueous humor to determine the cause of the intraocular inflammation. Results: Slit-lamp biomicroscopy showed focal iris atrophy and peripheral anterior synechiae (PAS; specular microscopy of the corneal endothelium disclosed the hammered-silver appearance. Based on these clinical findings, we diagnosed this patient as having Chandler's syndrome. During the follow-up period, however, the inflammatory cells suddenly appeared in the anterior chamber with formation of keratic precipitates and an increased intraocular pressure (IOP. VZV DNA was displayed in the aqueous humor by PCR. Based upon the diagnosis of VZV anterior uveitis, corticosteroids and acyclovir were given topically and systemically. The inflammation subsided with these medications; however, trabeculectomy was finally needed to control the IOP due to PAS progression. Conclusion: The coincidence of VZV anterior uveitis with Chandler's syndrome may constitute an implication for the possible viral etiology of iridocorneal endothelial syndrome.

  14. Uveitis in Thailand : emphasis on clinical patterns and novel developments in diagnostics using intraocular fluid analysis

    NARCIS (Netherlands)

    Pathanapitoon, K.

    2010-01-01

    In this thesis, we report on the so far unknown causes of uveitis in Thailand and describe their clinical manifestations. We found out that intraocular infections were the second most common cause of blindness and low vision in a tertiary center in northern Thailand. These infections predominantly c

  15. A review and update on orphan drugs for the treatment of noninfectious uveitis

    Science.gov (United States)

    You, Caiyun; Sahawneh, Haitham F; Ma, Lina; Kubaisi, Buraa; Schmidt, Alexander; Foster, C Stephen

    2017-01-01

    Introduction Uveitis, a leading cause of preventable blindness around the world, is a critically underserved disease in regard to the medications approved for use. Multiple immunomodulatory therapy (IMT) drugs are appropriate for uveitis therapy but are still off-label. These IMT agents, including antimetabolites, calcineurin inhibitors, alkylating agents, and biologic agents, have been designated as “orphan drugs” and are widely used for systemic autoimmune diseases or organ transplantation. Area covered The purpose of this paper is to comprehensively review and summarize the approved orphan drugs and biologics that are being used to treat systemic diseases and to discuss drugs that have not yet received approval as an “orphan drug for treating uveitis” by the US Food and Drug Administration (FDA). Our perspective IMT, as a steroid-sparing agent for uveitis patients, has shown promising clinical results. Refractory and recurrent uveitis requires combination IMT agents. IMT is continued for a period of 2 years while the patient is in remission before considering tapering medication. Our current goals include developing further assessments regarding the efficacy, optimal dose, and safety in efforts to achieve FDA approval for “on-label” use of current IMT agents and biologics more quickly and to facilitate insurance coverage and expand access to the products for this orphan disease. PMID:28203051

  16. Serum PEDF levels are decreased in a spontaneous animal model for human autoimmune uveitis.

    Science.gov (United States)

    Zipplies, Johanna K; Hauck, Stefanie M; Schoeffmann, Stephanie; Amann, Barbara; Stangassinger, Manfred; Ueffing, Marius; Deeg, Cornelia A

    2009-02-01

    Identification of biomarkers is of critical relevance toward improving diagnosis and therapy of autoimmune disorders. Serum markers are a desirable choice as sera are easily accessible and the development of assays for routine clinical detection prompts feasible. Autoimmune uveitis, a recurrent disease affecting the eye, is characterized by returning inflammatory attacks of the inner eye followed by variable periods of quiescent stages. Spontaneous equine recurrent uveitis (ERU) is the equine equivalent and serves as a model for the human disease. To identify potential biomarker candidates, we first systematically compared the proteomes of individual ERU cases with healthy controls by proteomic profiling using 2-D difference-gel-electrophoresis (2-D DIGE) followed by tandem mass spectrometry. A total of seven differentially expressed proteins were identified. Besides the upregulation of IgG and the significant lower expression of albumin, Antithrombin III, and Vitamin D binding protein, we found complement components C1q and C4, to be downregulated in uveitic state. Interestingly, Pigment epithelium-derived factor (PEDF), a marker already detected by 2DE differential proteome analysis in ERU target tissues, vitreous and retina, was found to be also significantly downregulated in sera. The lower expression of PEDF in sera of horses with uveitis could be verified in a cohort of 116 ERU cases and 115 healthy controls. Our findings of a significant lower PEDF expression in ERU cases also in the periphery of the eye proves PEDF as a promising uveitis biomarker.

  17. Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice

    Directory of Open Access Journals (Sweden)

    Yao Xin-Sheng

    2011-10-01

    Full Text Available Abstract Background Lutein is an important eye-protective nutrient. This study investigates the protective effects and mechanisms of lutein on lipopolysaccharides (LPS-induced uveitis in mice. Methods Lutein, suspended in drinking water at a final concentration of 12.5 and 25 mg/mL, was administered to mice at 0.1 mL/10 g body weight for five consecutive days. Control and model group received drinking water only. Uveitis was induced by injecting LPS (100 mg per mouse into the footpad in the model and lutein groups on day 5 after the last drug administration. Eyes of the mice were collected 24 hours after the LPS injection for the detection of indicators using commercial kits and reverse transcription-polymerase chain reaction. Results LPS-induced uveitis was confirmed by significant pathological damage and increased the nitric oxide level in eye tissue of BALB/C mice 24 hours after the footpad injection. The elevated nitric oxide level was significantly reduced by oral administration of lutein (125 and 500 mg/kg/d for five days before LPS injection. Moreover, lutein decreased the malondialdehyde content, increased the oxygen radical absorbance capacity level, glutathione, the vitamin C contents and total superoxide dismutase (SOD and glutathione peroxidase (GPx activities. Lutein further increased expressions of copper-zinc SOD, manganese SOD and GPx mRNA. Conclusion The antioxidant properties of lutein contribute to the protection against LPS-induced uveitis, partially through the intervention of inflammation process.

  18. In vivo Confocal Microscopy in Differentiating Ipilimumab-Induced Anterior Uveitis from Metastatic Uveal Melanoma

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    Hayyam Kiratli

    2016-09-01

    Full Text Available This report aims to describe the facilitating role of in vivo confocal microscopy in differentiating inflammatory cells from a metastatic process in a patient with uveal melanoma and multiple systemic metastases who developed anterior uveitis while under ipilimumab treatment. A 43-year-old woman developed systemic metastases 11 months after treatment of amelanotic choroidal melanoma in her right eye with 30 Gy fractionated stereotactic radiotherapy. She first received temozolomide and then 4 cycles of ipilimumab 3 mg/kg/day. After the third cycle, severe anterior uveitis with coarse pigment clumps on the lens was seen in the left eye. Her left visual acuity declined from 20/20 to 20/80. Confocal microscopy revealed globular keratic precipitates with hyperreflective inclusions and endothelial blebs all suggestive of granulomatous uveitis. The uveitic reaction subsided after a 3-week course of topical corticosteroids, and her visual acuity was 20/20 again. Although uveal melanoma metastatic to the intraocular structures of the fellow eye is exceedingly rare and metastasis masquerading uveitis without any identifiable uveal lesion is even more unusual, it was still mandatory to rule out this distant possibility in our particular patient who already had widespread systemic metastases. Confocal microscopy was a useful complementary tool by identifying the inflammatory features of the keratic precipitates.

  19. Clinical course and signs in patients with uveitis associated with ankylosing spondylitis

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    Refik Oltulu

    2013-09-01

    Full Text Available Aim: To evaluate clinical course and signs in patients withuveitis associated ankylosing spondylitis (AS.Methods: In this retrospective study we evaluated thepatients who were diagnosed as uveitis related to AS andfollowed up at the Ophthalmology Department of NecmettinErbakan University Hospital between May 2009 andJune 2012. Demographical features and clinical courseswere assessed.Results: Seventeen eyes of 13 patients were includedin the study. Nine patients (69.2% were male and four(30.8% were female. The mean age at presentation was38.54±9.61 years (range 28-63. Bilateral involvementwas observed in four (30.8% patients. The mean followuptime was 17.46±11.86 months (range 3-36. The meannumber of attacks was 1.15±0.37 (range 1-2. Posteriorsegment manifestation accompanied anterior uveitis inthree eyes (17.6%. Posterior synechia developed in one(7.7% and cataract in one patient (7.7%, cystoid macularedema in two patients (15.4%, and epiretinal membranein one patient (%7.7. The mean final visual acuitywas 0.975±0.07 (range 0.2-1.0.Conclusion: The prognosis of anterior uveitis associatedwith AS is good if the treatment is administered at theappropriate time. However, the posterior segment complicationsmay develop in these patients, treatment andfollow-up should be done in co-operation with the departmentof rheumatology.Key words: Ankylosing spondylitis, uveitis, rheumatology,clinical course

  20. Is there a genetic basis for Fuchs' heterochromic uveitis? Discordance in monozygotic twins.

    OpenAIRE

    Jones, N. P.; Read, A P

    1992-01-01

    One pair, and probably two pairs, of monozygotic twins are reported with discordance for Fuchs' heterochromic uveitis (FHU). Regular Mendelian inheritance of this disease is now proved to be impossible. The heritability of FHU is low and may be zero. The possibility of any genetic predisposition to the disease and its association with 'simple' heterochromia are discussed.

  1. Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis

    Science.gov (United States)

    Mehta, H; Sim, D A; Keane, P A; Zarranz-Ventura, J; Gallagher, K; Egan, C A; Westcott, M; Lee, R W J; Tufail, A; Pavesio, C E

    2015-01-01

    Aim The aim of this study is to characterise the choroidal features of patients diagnosed with sarcoid- and tuberculosis (TB)-associated granulomatous uveitis using spectral domain optical coherence tomography (OCT). Methods Twenty-seven patients (27 eyes) diagnosed with sarcoid- (13 eyes) and TB (14 eyes)-related uveitis were included in this retrospective, cross-sectional study. Over a six-month period, patients diagnosed with sarcoid and TB granulomatous uveitis were scanned using enhanced depth imaging OCT. Clinical and demographical characteristics were recorded, including the method of diagnosis, disease activity, site of inflammation (anterior or posterior), treatments, and visual acuity (VA). Manual segmentation of the choroidal layers was performed using custom image analysis software. Results The main outcome measure was OCT-derived thickness measurements of the choroid and choroidal sublayers (Haller's large vessel and Sattler's medium vessel layers) at the macula region. The ratio of Haller's large vessel to Sattler's medium vessel layer was significantly different at the total macula circle in eyes diagnosed with TB uveitis (1.47 (=140.71/95.72 μm)) compared with sarcoid uveitis (1.07 (=137.70/128.69 μm)) (P=0.001). A thinner choroid was observed in eyes with a VA ≥0.3 LogMAR (Snellen 6/12; 198.1 μm (interquartile range (IQR)=147.0–253.4 μm) compared with those with VA <0.3 LogMAR (292.4 μm (IQR=240.1–347.6 μm)) at the total macula circle (P=0.004). At the foveal central subfield, the median choroidal thickness was 336.8 μm (IQR=272.3–375.4 μm) in active compared with 239.3 μm (IQR=195.3–330.9 μm) in quiescent disease (P=0.04). Conclusion A disproportionately enlarged Sattler's layer may indicate a diagnosis of sarcoid-related uveitis, and choroidal thickening may be a feature of active granulomatous uveitis. PMID:26021867

  2. Sepsis neonatal por Estreptococos Pyogenes

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    Gilberto Rodríguez-Herrera

    2009-09-01

    Full Text Available Se presenta el caso de un paciente masculino, recién nacido a término adecuado para la edad gestacional, quien nace por parto vaginal, con el antecedente de fiebre en la madre durante el periodo de postparto inmediato. Los padres consultan a los 2 días de vida pues le notan dificultad respiratoria, hipoactividad y rechazo a la leche materna. El paciente se interna y se aborda como una sepsis. Durante su estancia en el servicio de neonatología del Hospital Nacional de Niños asocia fallo respiratorio que amerita ventilación mecánica asistida por varios días en diferentes ocasiones, derrame pleural exudativo, convulsiones de origen hipóxico isquémico. Con reporte de hemocultivos positivos por Estreptococos pyogenes. El Estreptococos pyogenes o estreptococo β-hemolνtico del grupo A, fue un problema en los comienzos del siglo pasado, siendo frecuente en las infecciones puerperales y del reciιn nacido. En la actualidad es un germen sumamente raro en los procesos de sepsis neonatal.2 La gravedad de la enfermedad causada por este microorganismo en el periodo neonatal varνa desde una onfalitis crónica de bajo grado a una septicemia, una meningitis fulminante y la muerte.1 El presente artículo pretende hacer un resumen del paciente, con su evolución clínica, radiológica y además ejemplificar todas las complicaciones que tuvimos con este germen tan poco frecuente en la actualidad en sepsis neonatal.

  3. Optic neuritis and acute anterior uveitis associated with influenza A infection: a case report

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    Nakagawa H

    2017-01-01

    Full Text Available Hayate Nakagawa, Hidetaka Noma, Osamu Kotake, Ryosuke Motohashi, Kanako Yasuda, Masahiko Shimura Department of Ophthalmology, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan Background: A few reports have described ocular complications of influenza A infection, such as impaired ocular movement, parasympathetic ocular nerve, keratitis, macular lesion, and frosted branch angiitis. We encountered a rare case of acute anterior uveitis and optic neuritis associated with influenza A infection. Case presentation: A 70-year-old man presented with symptoms of upper respiratory tract infection. A rapid diagnostic test showed a positive result for influenza A. At the same time, he developed ocular symptoms including blurred vision with optic disk edema and hemorrhage in the left eye, and bilateral red eyes. Multiplex polymerase chain reaction performed on aqueous humor sample detected no viral infection. Visual field testing with a Goldmann perimeter showed central and paracentral scotomas in the left eye. In addition to antiviral agent (oseltamivir phosphate 75 mg, the patient was prescribed topical prednisolone acetate ophthalmic suspension eye drops every 5 hours and high-dose intravenous methylprednisolone 1,000 mg daily for 3 days. Two months later, his best-corrected visual acuity improved to 20/50 with regression of visual field defects in his left eye. Conclusion: We report a case of bilateral acute anterior uveitis and unilateral optic neuritis concomitant with influenza A infection. Topical and systemic corticosteroids were effective to resolve acute anterior uveitis and neuritis. Analysis of aqueous humor sample suggested that acute anterior uveitis and optic neuritis in this case were not caused by influenza A virus infection per se but by autoimmune mechanism. Keywords: optic neuritis, anterior uveitis, influenza virus, multiplex polymerase chain reaction

  4. Analysis of juvenile idiopathic arthritis associated uveitis in India over the last 16 years

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    Sudharshan S

    2007-01-01

    Full Text Available Aim: Juvenile idiopathic arthritis (JIA associated uveitis is one of the most common causes of visual morbidity in children. We report the systemic, clinical and investigational features of a cohort of all cases of JIA associated uveitis seen at our referral uveitis clinic between 1988 and 2004. Study Design: Retrospective case series Materials and Methods: All patients of JIA seen at the uveitis clinic of tertiary eye care hospital, between 1988 and 2004 with minimum follow up of 3 months were included. Complete history and ophthalmic evaluation and findings on each visit were noted. Ocular complications were identified and recorded. Results of laboratory investigations and diagnostic as well as therapeutic procedures were analyzed. A rheumatologist managed systemic status. Results: There were 40 patients (64 eyes with JIA. Thirty four patients (85% had pauciarticular type and 6 patients (15% had polyarticular type of JIA. Complicated cataract and band shaped keratopathy were seen in 38 eyes (63% and 37 eyes (62% respectively. Twenty-two patients (17 bilateral and 5 unilateral were treated with immunosuppressives and in 19 of these patients, the disease went into remission. Twenty-three eyes (38% had improvement in visual acuity while in 27 eyes (45%, the vision remained stable and in 10 eyes (17%, vision deteriorated despite therapy. Conclusion: In India, JIA associated uveitis commonly presented in pauciarticular type with preponderance in males. Rheumatoid arthritis factor and anti nuclear antibodies were not as common as compared to the western population. Among long-term treatment options, immunosuppressives are a better choice. Ocular surgery was performed when mandatory for visual rehabilitation.

  5. Meningoencefalite causada pelo vírus vacinal da febre amarela transmitido pelo leite materno

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    Cristiane Traiber

    2011-06-01

    Full Text Available OBJETIVO: Relatar um caso de meningoencefalite, provavelmente causada pelo vírus vacinal da febre amarela transmitido pelo leite materno. DESCRIÇÃO: Paciente de 38 dias de idade, internado em 23/05/09 para investigação de febre. No dia 25/05/09 iniciaram-se as crises convulsivas. O exame do líquido cefalorraquidiano (LCR foi sugestivo de meningoencefalite. A mãe havia recebido dose da vacina contra febre amarela e o bebê estava em aleitamento materno exclusivo. Recebeu alta com controle das crises convulsivas. Foi detectado anticorpo IgM específico para febre amarela no soro e no LCR. COMENTÁRIOS: Em 2009, ocorreu o primeiro caso confirmado de meningoencefalite pelo vírus vacinal da febre amarela transmitido pelo leite materno. Descrevemos o segundo caso, em que, possivelmente, o vírus vacinal tenha sido o agente etiológico da meningoencefalite. O Ministério da Saúde do Brasil recomenda adiar a vacinação de nutrizes até a criança completar 6 meses ou orientar alternativas para evitar o risco de transmissão do vírus vacinal pelo leite materno.

  6. Lesões traumáticas de pele causadas pelos espinhos de Mimosa pudica e Mimosa debilis em equídeos

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    Alessandra S. Belo Reis

    2011-09-01

    Full Text Available Foram realizadas pesquisas sobre a natureza e causa de lesões de pele em equídeos em uma propriedade no município de Castanhal, região Nordeste do Estado do Pará. Foram realizadas visitas técnicas, estudos epidemiológicos, coletas de sangue, biópsias de pele afetada e a inspeção da pastagem. O estudo incluiu 25 equídeos, dos quais 14 machos e 11 fêmeas, de seis meses e oito anos de idade. Os animais apresentaram lesões ulcerativas, de bordos irregulares, na cabeça (narinas, focinho, lábios superiores e inferiores e chanfro, na cavidade oral (vestíbulo bucal e gengiva e nos membros (boletos, metacarpos e metatarsos e articulação escápulo-umeral. No exame histopatológico foram observados focos de erosões cutâneas, caracterizados por perda e necrose da epiderme, com espongiose, degeneração vesicular da epiderme remanescente e leve infiltrado inflamatório na derme subjacente, constituído predominantemente por macrófagos e, em menor grau, eosinófilos. Na inspeção da pastagem, constituída de Brachiaria humidicola, foi constatada grande invasão de duas plantas providas de espinhos, Mimosa pudica e Mimosa debilis, ambas da família Leg. Mimosoideae. Concluiu-se, que as lesões de pele foram causadas pela ação traumática dos espinhos de Mimosa pudica e Mimosa debilis.

  7. Vigilancia de diarreas por rotavirus en hospitales centinelas, Chile 2006-2008

    OpenAIRE

    Díaz Tito, Janepsy

    2010-01-01

    La infección por rotavirus es una de las más importantes causas de diarrea moderada a grave en niños menores de cinco años en todo el mundo. En Chile, la enteritis por rotavirus ha ido en aumento con el transcurso de los años. En el periodo de enero a diciembre de 2006-2008, se condujo una investigación operacional, con el propósito de desarrollar una estrategia de vigilancia que permitiera la caracterización integral de las diarreas causadas por rotavirus en niños chilenos menores de cinco a...

  8. Infección por toxoplasma: panorama actual

    OpenAIRE

    Palmezano Díaz, Jorge Mario; Plazas Rey, Lisette Katherine; Rojas Carvajal, Daniela

    2015-01-01

    Tema y alcance: este artículo pretende ofrecer al lector una mirada general sobre la toxoplasmosis, una zoonosis causada por Toxoplasma gondii, que afecta tanto a los hospederos intermediarios, como a los definitivos; buscamos que pueda entenderse la dinámica de la enfermedad, dejando de lado ciertos mitos sobre esta. Características: los félidos (Felidae) son los hospederos definitivos, entre los cuales encontramos a los gatos como los más cercanos al ser humano, que desarrollan la forma sex...

  9. Results of intravitreal dexamethasone implant 0.7 mg (Ozurdex~) in non-infectious posterior uveitis

    Institute of Scientific and Technical Information of China (English)

    Yew; Chong; Yap; Thomas; Papathomas; Ahmed; Kamal

    2015-01-01

    · AIM: To evaluate the safety and efficacy of dexamethasone implant in patients with non-infectious posterior uveitis with cystoid macular edema(CME).·METHODS: Retrospective analysis of patients reports with CME secondary to non-infectious uveitis treated with dexamethasone implant. Data included type of posterior uveitis, any systemic immunosuppressive therapy, Early Treatment Diabetic Retinopathy Study(ETDRS) best-corrected visual acuity(BCVA), central macular thickness(CMT) on optical coherence tomography(OCT) and signs of intraocular inflammation at baseline and then at 2wk postoperatively and monthly thereafter. Follow-up is up to 10 mo. Any per-operative and post-operative complications were recorded.·RESULTS: Six eyes of 4 patients with CME due to non-infectious posterior uveitis treated with dexamethasone implant. Diagnosis included idiopathic panuveitis, birdshot chorioretinopathy and idiopathic intermediate uveitis. At baseline mean ETDRS BCVA was63 letters and mean CMT 556 μm at 2wk postoperatively mean ETDRS BCVA improved to 70 letters and mean CMT decreased to 329 μm. All eyes showed clinical evidence of decreased inflammation. The duration of effect of the implant was 5 to 6mo and retreatment was required in 2 eyes. Two patients required antiglaucoma therapy for increased intraocular pressures.·CONCLUSION: In patients with non-infectious posterior uveitis dexamethasone implant can be a short-term effective treatment option for controlling intraocular inflammation.

  10. Patterns of uveitis at the Apex Institute for Eye Care in India: Results from a prospectively enrolled patient data base (2011-2013).

    Science.gov (United States)

    Venkatesh, Pradeep; Gogia, Varun; Shah, Bhavin; Gupta, Shikha; Sagar, Pradeep; Garg, Satpal

    2016-06-01

    The purpose of the study was to identify the clinical and etiological profile of uveitis at the apex institute for eye care in India. This is a prospective, prevalence study. 980 consecutive patients with uveitis referred to uvea clinic, Dr. RP Centre for Ophthalmic Sciences (Ophthalmology division, All India Institute of Medical Sciences). Demographic data of each patient were noted and a thorough ocular examination including slit lamp examination and dilated fundus evaluation was carried out. OCT and fluorescein angiography were undertaken whenever indicated. Uveitis was classified based on the anatomic location of inflammation (IUSG classification). Relevant serological and radiological investigations were obtained based on systemic symptomatology, and if the uveitis was recurrent (even in the absence of systemic symptoms). The presence of a systemic disease was confirmed by obtaining an internist consultation. The main outcome measures include pattern of uveitis according to anatomical classification and the etiology. Out of 980 patients with uveitis, 413 (42.14 %) patients had anterior uveitis, 131 (13.36 %) had intermediate uveitis, 165 (16.83 %) had posterior uveitis, 91 (9.2 %) had panuveitis, 47 (4.7 %) had retinal vasculitis, 22 (2.24 %) had scleritis, 17 (1.7 %) had masquerade syndromes, 8 (0.8 %) had keratouveitis, 22 (2.24 %) had sclerokeratouveitis, 19 (1.9 %) had endophthalmitis and 45 (4.5 %) had other causes of inflammation including trauma and intraocular surgery. Out of all uveitic patients definite etiological correlation could be made out in 225 (23 %) patients; thus 77 % were categorised as idiopathic. Only 9 % of all patients were found to have uveitis with an infectious etiology. Amongst infectious causes of uveitis tuberculosis was the leading cause, accounting for sixty percent of all infectious uveitis (approximately 5 % of overall uveitis). Non-infectious uveitis etiology accounted for more than 90 % of all cases with

  11. [Fuchs uveitis syndrome--heterochromia is no "conditio sine qua non"].

    Science.gov (United States)

    Becker, M D; Zierhut, M

    2005-07-01

    Fuchs uveitis syndrome (FUS) is typically a unilateral, chronic, low-grade inflammation of the anterior segment which manifests in young adulthood. It is underdiagnosed because of its variable clinical spectrum. Although it can mimic various forms of anterior uveitis, it is important to make the correct diagnosis, based on clinical grounds, because both the management and prognosis differ from those of other uveitides. While its etiology remains unknown, it is possible that the disease has multiple causes that lead through different pathogenic mechanisms to the same clinical entity. Although many patients do not require treatment, it is not a benign condition, as often perceived. The high incidence of glaucoma makes it mandatory that all patients with FUS should be screened at regular intervals, even if they are not being actively treated and are relatively asymptomatic.

  12. Two cases of exudative retina detachment and uveitis following H1N1 influenza vaccination

    Institute of Scientific and Technical Information of China (English)

    TAO Yong; CHANG Li-bing; ZHAO Min; LI Xiao-xin

    2011-01-01

    Uveitis was a rare adverse event of vaccination.We met two cases of acute uveitis with exudative retinal detachment following vaccination of H1N1 influenza.Case 1 was a 10-year-old boy who was admitted for bilateral blurred vision at 10 days after vaccination of H1N1 influenza.Vitreous opacity was obvious in both eyes.Broad exudative retinal detachment was observed in the right eye.Case 2 was a 47-year-old female who suffered from an acute high fever at 2 days after the vaccination of H1 N1 influenza.Later,she encountered bilateral headache and decreasing vision.In both eyes,mutton fat keratic precipitates,positive Tyndall phenomenon,congestion of optic disc and exudative retinal detachment were observed.

  13. Investigating the anti-inflammatory effects of curcumin on Endotoxin-induced uveitis in rabbits' eyes

    OpenAIRE

    Nader Kavian; 2Mohammadreza Talebnjad; Aida Seif; Ladan Mirzaei

    2016-01-01

    Corticosteriods are used in the treatment of inflammatory diseases of the eye such as uveitis, but these drugs have many side effects such as cataract and primary open angle glaucoma (POAG) and aggravation of keratitis caused by herpes simplex, fungal keratitis, etc. Therefore, the efforts to find new medicines that control ocular inflammation while lacking any steroid side effects continue. Curcumin is a yellow substance found in turmeric and in traditional medicine it is used as...

  14. Anterior Uveitis Caused by Ocular Side Effects of Afatinib: A Case Report

    Directory of Open Access Journals (Sweden)

    Daisuke Todokoro

    2016-02-01

    Full Text Available Afatinib is a second-generation epidermal growth factor receptor (EGFR inhibitor that has been shown to be effective against EGFR-mutated non-small cell lung cancer (NSCLC resistant to conventional EGFR inhibitors such as gefitinib and erlotinib. Although ocular side effects of gefitinib and erlotinib have been reported, those for afatinib have yet to be definitively established. This report presents details on the first case of unilateral iridocyclitis associated with the side effects of afatinib therapy. A 75-year-old Japanese male ex-smoker with EGFR-mutated NSCLC underwent afatinib therapy for multiple metastases. At 2 weeks, bilateral conjunctivitis developed. Topical medication and a 1-week afatinib washout period resulted in the improvement of the conjunctivitis. However, 3 days after the resumption of afatinib, the patient developed unilateral granulomatous anterior uveitis in his right eye. Best-corrected visual acuity (BCVA measurement indicated a decimal visual acuity of 0.2, while the slit-lamp findings were characterized by granulomatous inflammation, keratic precipitates, Koeppe nodules and posterior synechiae. There was no evidence suggesting other intraocular inflammatory disease or metastatic tumor. The left eye was intact. The use of topical medication including steroids and a washout of afatinib resulted in a gradual subsiding of the anterior uveitis. After resolution of the anterior uveitis, oral afatinib was resumed. BCVA of the right eye finally recovered to a decimal acuity of 1.0. Ophthalmologists should be aware of the possibility that side effects associated with afatinib could cause granulomatous anterior uveitis.

  15. 警惕梅毒性葡萄膜炎%To pay attention to syphilitic uveitis

    Institute of Scientific and Technical Information of China (English)

    张美芬

    2008-01-01

    近年来,世界各地的梅毒发病均呈上升趋势.有些患者以眼部葡萄膜炎为梅毒的首发表现,常被贻误诊治.梅毒的眼部表现多种多样,包括基质性角膜炎、前葡萄膜炎、中间葡萄膜炎、后葡萄膜炎、全葡萄膜炎及视神经病变,其中葡萄膜炎是梅毒最常见的眼部表现,可单眼或双眼发病.因此,对于病因不明的葡萄膜炎患者,眼科医师要警惕梅毒所致的葡萄膜炎,进行相关的血清学检查,一经确诊梅毒,首先除外是否合并有人免疫缺陷病毒感染,随后给予及时对症、对因的治疗.%There has been a dramatic increase in the incidence of syphilis over the last five years in the world.Some of the syphilitic patients have ocular uveitis as the initial presentation of syphilis,which may be misdiagnosed and can lead to a delay of treatment. Multiple manifestations of ocular syphilis include interstitial keratitis:anterior,intermediate,posterior uveitis and optic neuropathies.Uveitis,which my involve unilateral or bilateral eyes,is the most common ocular manifestation of syphilis.The serologic tests for syphilis should be considered for unexplained uveitis patients.All patients diagnosed with ocular syphilis should be tested for co-infection with human inununodeftciency virus.The preferred treatment for ocular syphilis remains hiish dose intravenous penicillin G.

  16. Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats

    DEFF Research Database (Denmark)

    Mangano, K; Sardesai, N Y; Quattrocchi, C

    2008-01-01

    VGX-1027 is a novel, low molecular weight, immunomodulatory compound that has shown efficacy against a variety of immuno-inflammatory disease models in animals including autoimmune diabetes in NOD mice, collagen-induced arthritis and chemically induced inflammatory colitis. Here, we have studied ...... the effects of VGX-1027 on the development of endotoxin-induced uveitis (EIU) in male Lewis rats, as a model of inflammatory ocular diseases in humans....

  17. Recurrent symptomatic intraocular pressure spikes during hemodialysis in a patient with unilateral anterior uveitis

    Directory of Open Access Journals (Sweden)

    Lim Su-Ho

    2013-02-01

    Full Text Available Abstract Background The relationship between intraocular pressure (IOP changes and hemodialysis has been evaluated for several decades. However, no report on an IOP rise in uveitis patients during hemodialysis has been previously documented. This report describes the case of an uveitis patient with repetitive IOP spikes associated with severe ocular pain during hemodialysis sessions, which resolved after glaucoma filtering surgery. Case presentation A 47-year-old male with diabetes and hypertension had complained of recurrent ocular pain in the left eye during hemodialysis sessions. A slit-lamp examination showed diffuse corneal epithelial edema with several white keratic precipitates and inflammatory cells (Grade 3+ in the anterior chamber of the left eye. No visible neovascularization or synechiae were visible on the iris or angle. Topical glaucoma eye-drops and intravenous mannitol before hemodialysis did not prevent subsequent painful IOP spikes in the left eye. At the end of hemodialysis, IOP averaged ~40 mmHg. After trabeculectomy with mitomycin C in the left eye, his IOP stabilized in the low-teens (range, 10–14 mmHg and no painful IOP spikes occurred during hemodialysis over the first postoperative year. Conclusion We present a case of recurrent painful IOP spikes during hemodialysis in a patient with unilateral anterior uveitis unresponsive to conventional medical treatment prior to hemodialysis. To our knowledge, this is the first case report of repetitive symptomatic IOP rise during hemodialysis in an uveitic glaucoma patient. This case highlights the importance of the awareness of the possibility that IOP may rise intolerably during hemodialysis in uveitis patients with a compromised outflow facility.

  18. Anti-ocular-inflammatory Effects of Salvia hypoleuca Extract on Rat Endotoxin-Induced Uveitis

    OpenAIRE

    Jasem Estakhr; Nasim Javdan

    2012-01-01

    Salvia hypoleuca is used in Iranian traditional medicine as an agent for treatment of some diseases and troubles. In this study, attention was focused on the antioxidant effect of Salvia hypoleuca. The aim of the present study was to determine the effects of Salvia hypoleuca extract on Endotoxin-Induced Uveitis (EIU) in rats. In addition, the endotoxin-induced expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins was determined in a mouse macrophage cell...

  19. Severe anterior uveitis associated with idiopathic dacryoadenitis in diabetes mellitus patient

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    Takahashi YY

    2011-05-01

    Full Text Available Yasuhiro Takahashi¹, Hirohiko Kakizaki¹, Akihiro Ichinose², Masayoshi Iwaki¹¹Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan; ²Department of Plastic Surgery, Kobe University, Kobe, Hyogo, JapanAbstract: A 38-year-old woman with diabetes mellitus complained of acute visual loss in the left eye (20/200 and swollen left upper eyelid. Slit lamp examination of the left eye revealed ciliary injection, posterior synechia iritis, numerous inflammatory cells, and fibrin exudates in the anterior chamber. T1-weighted enhanced magnetic resonance imaging demonstrated left lacrimal gland enhancement with inflammatory spread to the left anterior ocular segment. Blood examination showed increased blood sugar but the other components were within normal limits. The patient was treated with steroid pulse therapy (methylprednisolone 1 g/day × 3 days under a blood sugar control regimen in consultation with an endocrinologist, after which additional peribulbar injection of triamcinolone acetonide (40 mg was performed. Resolution of the anterior uveitis and the dacryoadenitis was obtained after 2 months and there was no recurrence 1 year after the therapy. This is a rare case of severe anterior uveitis caused by idiopathic dacryoadenitis in a patient with diabetes mellitus.Keywords: anterior uveitis, idiopathic dacryoadenitis, diabetes mellitus, magnetic resonance imaging, steroid

  20. Current aspects on the management of viral uveitis in immunocompetent individuals

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    Pleyer U

    2015-06-01

    Full Text Available Uwe Pleyer,1 Soon-Phaik Chee1–51Augenklinik, Charité– Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany; 2Ocular Inflammation and Immunology Service, Singapore National Eye Centre, 3Singapore Eye Research Institute, 4Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 5Duke-NUS Graduate Medical School Singapore, SingaporeAbstract: Viruses are a fundamental etiology of ocular inflammation, which may affect all structures of the organ. Advances in molecular diagnostics reveal an increasingly broader spectrum of virus-associated intraocular inflammation, including all members of the herpes family, rubella virus, and other more rare causes such as Epstein–Barr and chikungunya virus. In particular, viruses of the herpes family are important causes of anterior and posterior uveitis. Owing to their often fulminant clinical course and persistence in ocular tissues, a clear differential diagnosis between alpha- and beta-type herpes viruses is essential to guide acute and long-term treatment. Here, we review the epidemiology, clinical, and laboratory findings of virus-associated uveitis with emphasis on their therapy and management and include our own experience.Keywords: clinical trials, cytomegalovirus, herpes virus, infection, inflammation, treatment, uveitis

  1. [Clinical-immunological disorders in uveitis in patients with Behçet's syndrome].

    Science.gov (United States)

    Teplinskaia, L E; Kaliberdina, A F; Zaĭtseva, N S; Bulanova, T D; Katsnel'son, L A

    1994-01-01

    The results of comprehensive clinicoimmunologic examinations of 38 uveitis patients with Behçet's disease indicate that uveitis in the presence of Behçet's disease should be referred to multifactorial diseases to whose pathogenesis immunopathologic reactions in various combinations and genetic predisposition contribute much. Generalization of the process in the eye predominated in the clinical picture with involvement of the anterior and posterior segments, retinal vessels, this being combined with general somatic symptoms (aphthae on the buccal mucosa, genitals, arthritides, urethritis/cystitis symptoms, positive 'pricking' test). Study of the immunity status revealed depressed lymphocyte proliferative response to mitogen in 58.8% of patients, hyperimmunoglobulinemia of the A and M classes in 63.3%, impaired complex formation (increased levels of circulating immune complexes in 78.3% and cryoglobulin presence in 57.1%), and various combinations of these immunologic signs. The results indicated patients' infection with herpes virus, streptococcus, toxoplasma. An associative connection of Behçet's disease with A (II) red cell phenotype in 54.8% of patients (p < 0.05) suggests a relationship between genetic factors and the conditions of a specific geographic region. A variety of immunologic changes necessitated the use of corticosteroids, hemoperfusion, cytostatics, and immunity stimulants in the treatment of uveitis in Behçet's disease patients.

  2. Development of a dexamethasone intravitreal implant for the treatment of noninfectious posterior segment uveitis.

    Science.gov (United States)

    Whitcup, Scott M; Robinson, Michael R

    2015-11-01

    Uveitis is a group of ocular inflammatory disorders that can lead to severe vision loss. Despite advances in anti-inflammatory therapy, many patients are resistant to or intolerant of existing treatments. A biodegradable, sustained-release implant, dexamethasone intravitreal implant 0.7 mg (Ozurdex), has been developed to deliver dexamethasone to target tissues in the posterior segment of the eye, minimizing systemic drug exposure and limiting side effects. The implant releases dexamethasone over a period of up to 6 months as the poly(D,L-lactide-co-glycolide) polymer matrix of the implant is metabolized to carbon dioxide and water. The implant is placed in the vitreous of the eye with a single-use applicator in a sutureless, office-based procedure. Treatment with a single dexamethasone intravitreal implant in patients with noninfectious intermediate or posterior uveitis has been shown to produce significant improvements in intraocular inflammation and best-corrected visual acuity with treatment benefit sustained for 6 months. Dexamethasone intravitreal implant has also been shown to reduce central retinal thickness and improve best-corrected visual acuity in patients with macular edema of various etiologies. The implant has been approved for treatment of noninfectious uveitis involving the posterior segment, diabetic macular edema, and macular edema associated with branch and central retinal vein occlusion.

  3. Expression changes and novel interaction partners of talin 1 in effector cells of autoimmune uveitis.

    Science.gov (United States)

    Degroote, Roxane L; Hauck, Stefanie M; Treutlein, Gudrun; Amann, Barbara; Fröhlich, Kristina J H; Kremmer, Elisabeth; Merl, Juliane; Stangassinger, Manfred; Ueffing, Marius; Deeg, Cornelia A

    2013-12-06

    Autoimmune uveitis is characterized by crossing of blood-retinal barrier (BRB) by autoaggressive immune cells. Equine recurrent uveitis (ERU) is a valuable spontaneous model for autoimmune uveitis and analyses of differentially expressed proteins in ERU unraveled changed protein clusters in target tissues and immune system. Healthy eyes are devoid of leukocytes. In ERU, however, leukocytes enter the inner eye and subsequently destroy it. Molecular mechanisms enabling cell migration through BRB still remain elusive. Previously, we detected decreased talin 1 expression in blood-derived granulocytes of ERU cases, linking the innate immune system to ERU. Because changes in leukocyte protein expression pattern may play a role in pathological abnormalities leading to migration ability, we aimed at identifying interactors of talin 1 in leukocytes with immunoprecipitation, followed by LC-MS/MS for candidate identification. This enabled us to identify CD90 (Thy1) as novel interactor of talin 1 besides several other interactors. In blood-derived granulocytes from healthy individuals, CD90 was highly abundant and significantly reduced in ERU, especially in effector cells. Connection between talin 1 and CD90 and their expression differences in inflammation is an interesting novel finding allowing deeper insight into immune response of innate immune system and granulocyte migration ability in this organ-specific autoimmune disease.

  4. Enfermedades articulares y uveítis Articular diseases and uveitis

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    J.M. Benítez del Castillo

    2008-01-01

    Full Text Available La inflamación ocular es una manifestación clínica frecuente de múltiples enfermedades sistémicas autoinmunes, siendo de gran relevancia en las espondiloartropatías. Dentro del grupo de las espondiloartropatías existen diferentes entidades clínicas, asociándose a diferentes patrones de uveítis. Se han definido una serie de patrones discriminativos que relacionan formas concretas de uveítis con determinadas enfermedades sistémicas u oculares. La uveítis anterior aguda unilateral recidivante es la más frecuente en las espondiloartropatías, y puede ser la forma de inicio de una espondiloartropatía no diagnosticada previamente. La colaboración entre oftalmólogos y reumatólogos o internistas es fundamental para el correcto manejo y tratamiento de estos pacientes.Ocular inflammation is a common clinical manifestation related to several autoimmune systemic disorders, specially spondyloarthropaties. In this group, there are different clinical diseases that are related to special uveitic patterns. Several discriminative patterns have been defined that closely link uveitis with certain systemic or ophthalmic diseases. Unilateral recurrent anterior acute uveitis is the most frequent form of uveitis related to spondyloarthropaties, and is sometimes the initial manifestation of an undiagnosed spondyloarthropaty. The collaboration of ophthalmologists, rheumatologists and internal medicine specialists is very important for the correct management and treatment of these patients.

  5. Real-time PCR in infectious uveitis as an alternative diagnosis

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    Fabio Felipe dos Santos

    2011-08-01

    Full Text Available PURPOSE: Uveitis is a major visual impairment disease affecting parts or the entire uveal tract and occasionally the sclera, the cornea or the optic nerve. The disease is a major cause of ocular morbidity and blindness in immunocompetent and immunocompromised patients. In this work we analyzed the sensitivity and specificity of real-time PCR to detect the etiological agent from blood, plasma, vitreous and aqueous humor and compared with the diagnostic hypothesis. METHODS: Twenty-seven patients (13 male were studied and Real-time PCR method was used for the detection of herpes simplex virus 1 (HSV-1, herpes simplex virus 2 (HSV-2, varicella zoster virus (VZV, cytomegalovirus (CMV, Mycobacterium tuberculosis (TB and Toxoplasma gondii (Toxo in the aqueous humor as well as in the vitreous, blood and plasma. RESULTS: Our results showed the presence of Toxo, CMV, VZV or HSV-2 in 19.2% of aqueous humor samples, and in 30% of vitreous humor samples. In plasma and blood samples, only CMV was detected (11.1% and 3.7%, respectively. CONCLUSION: Real-time PCR was able to detect and to confirm diagnostic hypothesis in uveitis. Our data also confirms that vitreous humor is the best source for molecular diagnosis of infectious uveitis but indicates aqueous humor samples that are easier to obtain may also be appropriate to be tested by Real-time PCR.

  6. Golimumab as Rescue Therapy for Refractory Immune-Mediated Uveitis: A Three-Center Experience

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    Miguel Cordero-Coma

    2014-01-01

    Full Text Available Objective. To evaluate, in three Spanish tertiary referral centres, the short-term safety and efficacy of golimumab (GLM for treatment of immune-mediated uveitis resistant to previous immunosuppressive therapy. Methods. Nonrandomized retrospective interventional case series. Thirteen patients with different types of uveitis that were resistant to treatment with at least 2 previous immunosuppressors were included in this study. All included patients were treated with GLM (50 mg every four weeks during at least 6 months. Clinical evaluation and treatment-related side effects were assessed at least four times in all included patients. Results. Eight men and 5 women (22 affected eyes with a median age of 30 years (range 20–38 and active immune-mediated uveitides were studied. GLM was used in combination with conventional immunosuppressors in 7 patients (53.8%. GLM therapy achieved complete control of inflammation in 12/13 patients (92.3% after six months of treatment. There was a statistically significant improvement in mean BCVA (0.60 versus 0.68, P=0.009 and mean 1 mm central retinal thickness (317 versus 261.2 μ, P=0.05 at the six-month endpoint when compared to basal values. No major systemic adverse effects associated with GLM therapy were observed. Conclusions. GLM is a new and promising therapeutic option for patients with severe and refractory uveitis.

  7. Validation of a Brief Questionnaire Measuring Positive Mindset in Patients With Uveitis

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    John A. Barry

    2014-03-01

    Full Text Available AimIllness may impact the positivity of a person’s mindset. However, patients with visual impairment, such as uveitis, may struggle to complete questionnaires. The aim of this study was to validate a brief and simple measure of positive mindset in people with uveitis.MethodThis study was a cross-sectional survey of 200 people with uveitis. The Positive Mindset Index (PMI questionnaire uses six items to measure a patient’s happiness, confidence, sense of being in control, stability, motivation, and optimism. ResultsExploratory factor analysis revealed a well-fitting unidimensional factor structure (KMO = .898, with strong factor loadings (from .616 to .721 and excellent internal reliability (Cronbach’s α = .926. The PMI showed strong concurrent validity with the mental health subscale of the SF-36 (r = .789 and good construct validity relative to the physical health subscale of the SF-36 (r = .468. Excellent test-retest reliability was seen (r = .806. Patients taking 10 mg or more corticosteroid daily had significantly lower PMI scores than those on a lower dose or no dose (t (170 = 2.298, p < .023.ConclusionThe PMI has good face validity and sound psychometric properties. It is a very brief and simple measure, thus user-friendly for patients with visual impairment, as well as researchers and others using the scale.

  8. Regulatory T cell levels and cytokine production in active non-infectious uveitis: in-vitro effects of pharmacological treatment.

    Science.gov (United States)

    Molins, B; Mesquida, M; Lee, R W J; Llorenç, V; Pelegrín, L; Adán, A

    2015-03-01

    The aim of this study was to quantify the proportion of regulatory T cells (Treg ) and cytokine expression by peripheral blood mononuclear cells (PBMCs) in patients with active non-infectious uveitis, and to evaluate the effect of in-vitro treatment with infliximab, dexamethasone and cyclosporin A on Treg levels and cytokine production in PBMCs from uveitis patients and healthy subjects. We included a group of 21 patients with active non-infectious uveitis and 18 age-matched healthy subjects. The proportion of forkhead box protein 3 (FoxP3)(+) Treg cells and intracellular tumour necrosis factor (TNF)-α expression in CD4(+) T cells was determined by flow cytometry. PBMCs were also either rested or activated with anti-CD3/anti-CD28 and cultured in the presence or absence of dexamethasone, cyclosporin A and infliximab. Supernatants of cultured PBMCs were collected and TNF-α, interleukin (IL)-10, IL-17 and interferon (IFN)-γ levels were measured by enzyme-linked immunosorbent assay (ELISA). No significant differences were observed in nTreg levels between uveitis patients and healthy subjects. However, PBMCs from uveitis patients produced significantly higher amounts of TNF-α and lower amounts of IL-10. Dexamethasone treatment in vitro significantly reduced FoxP3(+) Treg levels in PBMCs from both healthy subjects and uveitis patients, and all tested drugs significantly reduced TNF-α production in PBMCs. Dexamethasone and cyclosporin A significantly reduced IL-17 and IFN-γ production in PBMCs and dexamethasone up-regulated IL-10 production in activated PBMCs from healthy subjects. Our results suggest that PBMCs from patients with uveitis express more TNF-α and less IL-10 than healthy subjects, and this is independent of FoxP3(+) Treg levels. Treatment with infliximab, dexamethasone and cyclosporin A in vitro modulates cytokine production, but does not increase the proportion of FoxP3(+) Treg cells.

  9. Expression of intercellular adhesion molecule-1and HLA-DR antigens in uveitis

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    目的:研究细胞间粘附分子-1(intellular adhesion molecule-1,ICAM-1)和人体组织相关抗原(human leudocyte antigen,HLA-DR)在萄萄膜炎免疫反应中的作用.方法:应用免疫组织化学染色检查20只正常眼和54例葡萄糖膜炎眼球摘除眼(其中外源性33例和内源性21例)的脉络膜和视网膜组织中ICAM-1和HLA-DR的表达.结果:正常眼的脉络膜和视网膜组织没有ICAM-1的阳性染色,没有或较少有HLA-DR的表达,葡萄膜炎眼中二者有增高表达(P<0.01),而外源性和内源性葡萄膜炎眼组间表达统计学上无显著差异(P>0.05).结论:ICAM-1、HLA-DR分子能够介导白细胞和炎症部位组织细胞的识别和粘附,二者的共同表达说明它们在葡萄糖膜炎脉络膜视网膜组织的免疫性损伤中具有重要意义.%Objective :To study the effects of intercellular adhesion molecule-1 (ICAM-1) and human leukocyte antigen (HAL-DR) on the immunopathologic process of uveitis. Methods:Imn- munohistochemical techniques were applied to detect their expression in eyes of both the health (20 cases from eye bank) and patients with uveitis (54 cases with 54 eyes which included 33 ex- ogenous uveitis and 21 endogenous one). Results:Both the two ant igens were detectable in the choroidal and retinal tissues in eyes of uveitis while all the normal eyes showed negative expres- sion of ICAM-1 and negative or little expression of HLA-DR (P<0. 01). However,there was no statistically significant difference between exogenous and endogenous types (P>0. 05). Conclu- sion: Both ICAM-1 and HLA-DR may be responsible for cell recognition and binding in the in- flarnmatory tissues. The co-expression of ICAM-1 and HAL-DR showed that these two factors might play an important role in the immunologic damage of the choroid and retina in uveitis.

  10. Efficacy of genetically engineered biological agents in the treatment of uveitis associated with rheumatic diseases in children

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    V V Neroyev

    2012-01-01

    Full Text Available The efficiency of incorporating genetically engineered biological agents (GEBAs into a combination treatment regimen for rheumatic diseases (RD (juvenile idiopathic arthritis, Behcet's disease in relation to associated uveitis of varying severity was studied in 92 children aged 2 to 17 years. The follow-up lasted 1.5 to 49 months. Twenty-three patients took consecutively 2 to 5 GEBAs. When infliximab was used, remission of uveitis occurred in 21% of 38 children and the disease activity and/or recurrence rates reduced in an additional 21%. These were in 45 and 38.6% of 44 patients on adalimumab (ADA and in 27.8 and 27.8% of 18 patients on abatacept, respectively. There was an association of the efficiency of therapy with the severity of uveitis at the start of treatment. The use of ADA induced a steady remission of panuveitis resistant to therapy with glucocorticoids and cyclosporine in both patients with Behcet's disease. One of 4 rituximab-treated patients achieved a steady remission. Tocilizumab therapy caused an exacerbation of uveitis in 1 patient. The postoperative period showed no inflammatory complications in most cases (37 operations, 26 eyes, 20 patients. No local adverse reactions were seen; systemic reactions occurred in 14% of the patients, this caused GEBAs to be discontinued in 7%. There is evidence for a need for further investigations into the efficacy of GEBAs in RD-associated uveitis in children in order to define success criteria, differentiated indications, and therapy regimens.

  11. 葡萄膜炎的生物治疗进展%Advance in the biological therapy of uveitis

    Institute of Scientific and Technical Information of China (English)

    李燕利; 杨炜

    2013-01-01

    葡萄膜炎多发于青壮年,多为自身免疫性疾病,常反复发作.研究表明,生物制剂可以干扰机体内引起炎症反应过程的具有特定分子或途径,在葡萄膜炎的发病过程中发挥了关键的治疗作用,以达到治疗葡萄膜炎的目的.本文意在探讨抗肿瘤坏死因子制剂、白细胞介素受体拮抗剂、干扰素、抗淋巴细胞特异性抑制剂等生物制剂在葡萄膜炎治疗过程中的治疗进展.%Most of uveitis is a kind of autoimmune diseases. Uveitis often occurs in the young adults and frequently relapses. Studies show that biological preparations can interfere with the specific molecules or pathways which cause inflammatory reaction process in the body, which play a critical role in the treatment of onset progress of uveitis to achieve the purpose of treatment of uveitis. This paper discusses the progress of biological preparations such as anti tumor necrosis factor agents, interleukin receptor antagonists, interferon and anti lymphocyte specific inhibitors applied in the treatment of uveitis.

  12. Dry eye disease and uveitis: A closer look at immune mechanisms in animal models of two ocular autoimmune diseases.

    Science.gov (United States)

    Bose, Tanima; Diedrichs-Möhring, Maria; Wildner, Gerhild

    2016-12-01

    Understanding the immunopathogenesis of autoimmune and inflammatory diseases is a prerequisite for specific and effective therapeutical intervention. This review focuses on animal models of two common ocular inflammatory diseases, dry eye disease (DED), affecting the ocular surface, and uveitis with inflammation of the inner eye. In both diseases autoimmunity plays an important role, in idiopathic uveitis immune reactivity to intraocular autoantigens is pivotal, while in dry eye disease autoimmunity seems to play a role in one subtype of disease, Sjögren' syndrome (SjS). Comparing the immune mechanisms underlying both eye diseases reveals similarities, and significant differences. Studies have shown genetic predispositions, T and B cell involvement, cytokine and chemokine signatures and signaling pathways as well as environmental influences in both DED and uveitis. Uveitis and DED are heterogeneous diseases and there is no single animal model, which adequately represents both diseases. However, there is evidence to suggest that certain T cell-targeting therapies can be used to treat both, dry eye disease and uveitis. Animal models are essential to autoimmunity research, from the basic understanding of immune mechanisms to the pre-clinical testing of potential new therapies.

  13. Sialoadenitis purulenta submaxilar producida por cuerpo extraño en el conducto de Wharton.

    OpenAIRE

    2014-01-01

    Una causa frecuente de infección crónica de la glándula submaxilar es la obstrucción de su  conducto excretor que puede ser causada por litiasis, tapones de moco o a por la presencia de un cuerpo extraño. En las tres circunstancias se desarrollan cuadros de inflamación crónica del conducto (sialodoquitis) y de la glándula (sialoadenitis). Los estudios de imágenes radiográficas adecuadas son de gran utilidad para el diagnóstico, puesto que revelan el elemento obstructivo.La presencia dentro de...

  14. CARACTERIZACIÓN NO DESTRUCTIVA DEL ENDURECIMIENTO POR PRECIPITACIÓN DE UN ACERO 17-4PH

    OpenAIRE

    García Pérez, Ivan Xicotencatl

    2012-01-01

    El acero endurecible por precipitación 17-4 PH ha sido usado ampliamente, debido a que presenta una combinación balanceada de propiedades mecánicas y una buena resistencia a la corrosión. La temperatura de trabajo de este acero está por debajo de los 390 ̊C. Existe una gran preocupación en la industria ya que después de una exposición prolongada a esta temperatura, presentan degradación de sus propiedades, causada por envejecimiento. Los ensayos no destructivos ofrecen gran ...

  15. DETERMINACION DEL ORIGEN Y MECANISMO DE CONTAMINACION POR METALES Y METALOIDES EN LOS SUELOS DEL VALLE DE PUCHUNCAVÍ (Chile)

    OpenAIRE

    Parra Vargas, Sonnia MarbelL

    2013-01-01

    El impacto ambiental que sobre el suelo está ejerciendo el hombre ha originado que su contaminación sea uno de los problemas medio ambientales que está recibiendo una constante atención en los últimos años. La contaminación del suelo en Chile ha sido causada principalmente por elementos traza que emiten diversas actividades industriales, los cuales pueden contaminar al suelo por vía aérea a través de la deposición de material particulado de diferente granulometría y por emisiones gaseosas....

  16. Espondilite anquilosante e uveíte: revisão Ankylosing spondylitis and uveitis: overview

    Directory of Open Access Journals (Sweden)

    Enéias Bezerra Gouveia

    2012-10-01

    Full Text Available O presente trabalho propõe uma revisão de epidemiologia, patogênese, quadro clínico, diagnóstico e tratamento da espondilite anquilosante e sua associação com alteração ocular com a devida condução da doença e suas manifestações. Os autores utilizaram em sua pesquisa os bancos de dados PubMed (MEDLINE, LILACS e Biblioteca do Centro de Estudos de Oftalmologia. A espondilite anquilosante é uma doença inflamatória crônica que acomete preferencialmente o esqueleto axial, podendo evoluir com rigidez e limitação funcional progressiva. Seu início costuma ocorrer por volta da segunda à terceira década de vida, preferencialmente em indivíduos do gênero masculino, caucasianos e HLA-B27-positivos. Sua etiologia e patogênese não são completamente elucidadas, e seu diagnóstico costuma ser tardio. O controle clínico e o tratamento são frequentemente satisfatórios.A uveíte anterior aguda é a manifestação extra-articular mais comum, ocorrendo em cerca de 20%-30% dos pacientes com espondilite anquilosante. Aproximadamente metade dos casos de uveíte anterior aguda está associada à presença do antígeno HLA-B27, podendo ser a primeira manifestação de uma doença reumatológica não diagnosticada, geralmente com boa resposta terapêutica e bom prognóstico. Concluímos que, para melhor avaliação e tratamento dos pacientes com uveíte, é importante maior integração entre oftalmologistas e reumatologistas.The present article reviews the epidemiology, pathogenesis, clinical features, diagnosis, and treatment of ankylosing spondylitis and its association with ocular changes. The authors used the PubMed (MEDLINE, LILACS, and Ophthalmology Library databases. Ankylosing spondylitis is a chronic inflammatory disease that usually affects the axial skeleton and can progress to stiffness and progressive functional limitation. Ankylosing spondylitis usually begins around the second to third decade of life, preferentially in HLA

  17. 儿童葡萄膜炎临床分析%Clinical characteristics and visual prognostics of pediatric uveitis

    Institute of Scientific and Technical Information of China (English)

    郑曰忠; 时冀川

    2010-01-01

    Objective To describe the disease characteristics, the rate of complications and the visual outcome of pediatric uveitis under the age of 16 years in Tianjin, Northern of China. Methods The retrospective cases analysis methods were used. Of 106 cases (165 eyes) of pediatric uveitis were collected in Tianjin Eye Hospital fiom January 2005 to January 2009. The classifications of uveitis were determined by the history,detailed ocular and systemic examinations. The uveitis characteristics, complications, treatments and visual outcomes were analyzed. Results Total of 106 cases of uveitis in children were collected. Males were 45 cases,females were 61 cases (1:1.4). The mean age at diagnosis was 10.9± 3.3 years old. The acute onset was 18 cases (17.0%), the chronic onset was 37 cases (34.9%) and the relapsed was 51 cases (48.1%). The unilateral onset was 47 cases (47 eyes), the bilateral onset was 59 cases (118 eyes). The most frequent clinical types of uveitis included anterior uveitis 52 cases (49.1%), intermediate uveitis 31 cases (29.2%), panuveitis 15 cases (14.2%)and posterior uveitis 8 cases (7.5%). The infectious uveitis was 15 cases (14.2%) and the non-infectious or idiopathic inflammation was 91 cases (85.8%). Among the 106 cases of patients, idiopathic anterior uveitis was 36cases (34.0%), idiopathic intermediate uveitis was 31 cases (29.2%), idiopathic panuveitis was 13 cases (12.3%), combined with juvenile idiopathic arthritis was 10 cases (9.4%) and viral anterior uveitis was 5 cases (4.7%). The complications occurred among the 58 eyes (35.2%), there were posterior synechiae (21.8%), complicated cataract (17.0%), secondary glaucoma (9.7%), band keratopathy (9.7%) and cystoid macular edema (8.5%). The prevalence of visual impairment (less than 0.5 at the final visit) was 27.3% and the legal blindness (less than 0.1) was 9.7%. Conclusions Anterior uveitis is the most common type among the pediatric uveitis,the following are intermediate uveitis and

  18. Uveitis in patients with diagnosis of seronegative spondyloarthropathies. Hospital Pablo Tobón Uribe, Medellín, Colombia.

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    Carlos Andrés Molina

    2009-11-01

    Full Text Available Objective: To describe the inflammatory ocular manifestations in patients with diagnosis of spondyloarthropathies. Design: Descriptive study, longitudinal series of cases. Methods: In patients fulfilling inclusion criteria was carried out a complete ophthalmologic examination. The medical histories were revised. Data were registered in a previously built form. Results and conclusions: Frequency of uveitis, 37.5%; unilateral, 88.9%; and bilateral, 11.1%; not alternating, 88.9%; recurrence, 77.8%; anterior uveitis, 88.9%; cataracts were the main complication; in most of the patients the inflammation was resolved spontaneously; ocular inflammation usually was present after the beginning of the systemic symptoms. The most frequent spondyloarthropathy was ankylosing spondylitis in 58.3%. In conclusion, this study describes the connection between uveitis and spondyloarthropathies as given in the literature and it represents the first study showing this relationship behavior in Medellín, Colombia.

  19. Cytokine profile in human eyes: contribution of a new cytokine combination for differential diagnosis between intraocular lymphoma or uveitis.

    Science.gov (United States)

    Fisson, Sylvain; Ouakrim, Hanane; Touitou, Valérie; Baudet, Sylvie; Ben Abdelwahed, Rym; Donnou, Sabrina; Miloudi, Amine; Galand, Claire; Bodaghi, Bahram; Lehoang, Phuc; Brissard, Martine; Le Garff-Tavernier, Magali; Fridman, Wolf Herman; Sautès-Fridman, Catherine; Cassoux, Nathalie; Merle-Béral, Hélène

    2013-01-01

    Primary intraocular lymphoma (PIOL), also called primary vitreoretinal lymphomas, often masquerades as uveitis. This misdiagnosis can result in subsequent brain involvement and oculocerebral lymphoma (OCL). In this study, we sought to characterize the helper T-cell type 1 (Th1)/Th2 cytokine profile in vitreous samples from patients with PIOL, OCL, uveitis and controls with non-inflammatory disease. Vitreous and aqueous humor samples from 87 patients with PIOL (n = 30), OCL (n = 12), uveitis (n = 34), and retinal detachment (RD) without hemorrhage (n = 11) were analyzed and their concentrations of interleukin (IL)-2, IL-4, IL-6, IL-10, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α were determined by flow cytometric bead arrays (CBA). The IL-10 levels determined by CBA were compared with those by ELISA. IL-10 concentrations measured by CBA and ELISA were highly correlated. IL-2, IL-4, and TNFα were not detected in any sample. The only cytokine detected at a significant level in samples from RD vitreous was IL-6. The IL-10/IL-6 ratio, as previously reported, was slightly higher in PIOL than in uveitis samples, but not for all patients. Cytokine profiles from PIOL and OCL samples did not differ. The combination of the IL-10/IL-6 and IL-10/IFNγ ratios was highly informative for discriminating PIOL/OCL from uveitis samples and for therapeutic follow up of PIOL. This strategy might be very helpful as an initial screening to rule out PIOL in patients thought to have uveitis.

  20. Spontaneously relapsing-remitting experimental autoimmune uveitis in rats allows successful therapeutic oral tolerance induction in ongoing disease.

    Science.gov (United States)

    Huber, Andrea; Diedrichs-Möhring, Maria; Wildner, Gerhild

    2015-02-01

    Antigen-specific tolerance induction is a desired therapy for uveitis patients. Our relapsing-remitting rat model of experimental autoimmune uveitis (EAU) induced with IRBP peptide R14 enables us to test the effect of oral tolerance on the prevention of relapsing uveitis. We investigated several peptides overlapping the sequence of R14 for prevention and different doses of R14 for therapy to determine the tolerogenic epitope and the most effective therapeutic regimen for uveitis. Lewis rats were immunized with R14-CFA to induce EAU. Oral tolerance was induced prior to immunization (prevention) or after onset of EAU to prevent relapses (therapy). Therapeutic feeding was performed with high and/or low doses of oral antigen for clonal deletion of effector and induction of regulatory T cells. Uveitis was determined clinically and histologically; mesenteric lymph node (mLN) cells of tolerized rats were tested for surface markers, cytokines and Foxp3 expression. Preventive feeding of R14 and its major epitope R16, but none of the overlapping peptides significantly suppressed EAU and also prevented relapses, irrespective of their pathogenicity. Therapeutic feeding with R14 dramatically reduced relapses, while only the consecutive feeding of high and low-dose R14 had an ameliorating effect on the first course of disease. IL-10-producing T cells from mLN decreased after oral tolerization, and with R14-stimulation in vitro the TCRαβ+/Foxp3+ population increased in the low-dose fed group. No mLN population could be clearly assigned to successful oral tolerance induction during active autoimmune uveitis.

  1. Clinical analysis of the uveitis%葡萄膜炎的临床分析

    Institute of Scientific and Technical Information of China (English)

    樊伟英; 李健; 李明新; 牟莉

    2012-01-01

    Objective To analyse the clinical classification , etiologies and the present therapeutic method of uvei -tis. Methods Collect ophthalmology treatment of uveitis 166 cases (236 eyes) from February 2008 to November 2011 , then make a retrospective analysis for their clinical data . Results In total number of 166 patients , Anterior uveitis were 90 cases accounting for 54. 22% of all the patients , Intermediate uveitis (15 cases ,9. 04% ) , Posterior uveitis (10 cases ,6. 02% ) , and Panuveitis (51 caes,30. 72% ). As the etiological factor, Anterior were found in 99 patients accounting for 57. 91% of all the patients , and the other 67 patients were idiopathic ones and complications were 105 cases (63. 25% ). By use of glucocorticoids to expand pupil , non-steroidal anti inflammatory drugs, and immunosuppressant treatment as a comprehensive treatment to make a active treatment for complication , the visual acuity of patients was significantly improved. Conclusion Treatment of uveitis is still difficult and the visual rehabilitation is not optimistic at present because of its complicated etiology , long duration , easy replase , esay blindness , esay complication , but the majority of blindness and low vision caused by uveitis can be prevented and treated if given a timely diagnosis and treatment .%目的 探讨葡萄膜炎的临床类型、病因和目前临床治疗方法.方法 收集2008年2月至2011年11月我院眼科治疗门诊及病房收集的各类葡萄膜炎病例166例(236只眼),对其临床资料进行回顾性分析.结果 在166例葡萄膜炎患者中,前葡萄膜炎90例,占54.22%;中间葡萄膜炎15例,占9.04%;后葡萄膜炎10例,占6.02%;全葡萄膜炎51例,占30.72%.能够确定病因99例,占59.64%,其余为特发性患者67例,占40.36%.出现并发症及合并症的有105例(63.25%).采用糖皮质激素、散瞳、非甾体类消炎药及免疫抑制剂等综合治疗方案,积极治疗其并发症和合并症,患者治疗

  2. American Uveitis Society Meeting October 30, 1995 Marriott Marquis Hotel, Atlanta, GA, USA.

    Science.gov (United States)

    Meisler, D M; Chern, K C

    1996-01-01

    1 Retinal vascular occlusion and scleroderma. Tessler H, Flores-Guevara J, Goldstein D, Chicago, IL, USA. 2 MHC Class II antigen expression in ciliary body in spontaneous and experimental uveitis. Kalsow C, Zhavoronkova M, Dwyer A, Rochester, NY & Scottsville, NY, USA. 3 IL-10 in the vitreous of patients with intraocular lymphoma. Whitcup S, Solomon D, Nussenblatt R, Chan C-C, Bethesda, MD, USA 4 Iris juvenile xanthogranuloma studied by immunohistochemistry. Shields J, Shields C, Eagle R, DePotter P, Collins M, Philadelphia, PA, USA. 5 Outcomes analysis in with JRA-associated uveitis. Dana M-R, Merayo-Lloves J, Foster C, Boston MA, USA. 6 Persistent glaucoma secondary to periocular steroids. Akduman L, Conway M, Burchfield J, Kolker A, Black D, DelPriore L, Kaplan H, St. Louis, MO, USA 7 The use of itraconazole in ocular histoplasmosis Callanan D, Fish G, Dallas, TX, USA 8 Succesful treatment of macular hole secondary to sympathetic ophthalmia. Cano J, Diaz M, Navea A, Ruiz C, Castilla M. Barcelona, Spain. 9 HLA-DR2+ intermediate uveitis. Pulido J, Tang W, Han D, Mieler W. Milwaukee, WI, USA. 10 Vein occlusion in AIDS misdiagnosed as CMV retinitis. Park K, Marx J, Rao N. Los Angeles, CA, USA. 11 HIV-associated foveal hemorrhage. Crews K, Zimmerman P, Lohner S. Salt Lake City, UT, USA. 12 Cytomegalovirus papillitis in patients with AIDS. Patel S, Rutzen A, Marx J, Thach A, Chong L, Rao N, Los Angeles, CA, USA. 13 Recurrence rate of CMV retinitis following the ganciclovir implant and pars plans vitrectomy and silicone oil. Marx J, Thach A, Rao N, Chong L. Los Angeles, CA, USA.

  3. Administration of Mycobacterium leprae rHsp65 aggravates experimental autoimmune uveitis in mice.

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    Eliana B Marengo

    Full Text Available The 60 kDa heat shock protein family, Hsp60, constitutes an abundant and highly conserved class of molecules that are highly expressed in chronic-inflammatory and autoimmune processes. Experimental autoimmune uveitis [EAU] is a T cell mediated intraocular inflammatory disease that resembles human uveitis. Mycobacterial and homologous Hsp60 peptides induces uveitis in rats, however their participation in aggravating the disease is poorly known. We here evaluate the effects of the Mycobacterium leprae Hsp65 in the development/progression of EAU and the autoimmune response against the eye through the induction of the endogenous disequilibrium by enhancing the entropy of the immunobiological system with the addition of homologous Hsp. B10.RIII mice were immunized subcutaneously with interphotoreceptor retinoid-binding protein [IRBP], followed by intraperitoneally inoculation of M. leprae recombinant Hsp65 [rHsp65]. We evaluated the proliferative response, cytokine production and the percentage of CD4(+IL-17(+, CD4(+IFN-gamma(+ and CD4(+Foxp3(+ cells ex vivo, by flow cytometry. Disease severity was determined by eye histological examination and serum levels of anti-IRBP and anti-Hsp60/65 measured by ELISA. EAU scores increased in the Hsp65 group and were associated with an expansion of CD4(+IFN-gamma(+ and CD4(+IL-17(+ T cells, corroborating with higher levels of IFN-gamma. Our data indicate that rHsp65 is one of the managers with a significant impact over the immune response during autoimmunity, skewing it to a pathogenic state, promoting both Th1 and Th17 commitment. It seems comprehensible that the specificity and primary function of Hsp60 molecules can be considered as a potential pathogenic factor acting as a whistleblower announcing chronic-inflammatory diseases progression.

  4. Retinal blood flow velocity in patients with active uveitis using the retinal function imager

    Institute of Scientific and Technical Information of China (English)

    FENG Xing; Kedhar Sanjay; Bhoomibunchoo Chavakij

    2013-01-01

    Background Previous studies suggest a link between macular edema and retinal blood flow velocity (RBFV).The effects of inflammation in the retinal blood vessels are not clearly understood.We want to evaluate the differences in retinal blood flow velocities of patients with active uveitis and healthy controls using the retinal function imager (RFI)and determine the correlation between retinal blood flow veiocity and central macular thickness in uveitis patients.Methods Twenty-eight eyes of 24 patients with active anterior uveitis and 51 eyes of 51 normal control subjects were enrolled.Retinal blood flow velocities evaluated by RFI and central macular thickness evaluated by optical coherence tomography (SLO-OCT) were obtained.Differences among the groups were assessed using Stata statistical software.Results Ten eyes had uveitic cystoid macular edema (CME).Median (first quartile,third quartile) venous velocity for uveitic eyes with CME,uveitic eyes without CME,and controls were 2.09 (1.92,2.44),2.64 (2.32,2.86),and 2.82 (2.39,3.53) mm/s respectively.Median (first and quartile) arterial velocity for uveitic eyes with CME,uveitic eyes without CME,and controls were 3.79 (3.61,4.09),3.46 (2.86,4.12),and 3.93 (3.35,4.65) mm/s.Uveitic eyes with CME had significantly lower venous velocity than controls (P=0.044).There was a strong linear relationship between venous velocity and central retinal thickness (P=-0.007).Conclusions Retinal venous velocities were significantly decreased in eyes with uveitic CME relative to controls.Decreased venous velocity was correlated with increased central retinal thickness in uveitic eyes.

  5. Acute anterior uveitis after discontinuation of tocilizumab in a patient with rheumatoid arthritis

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    Sato T

    2014-01-01

    Full Text Available Tomohito Sato,1 Shinya Minakuchi,1 Manabu Mochizuki,2 Masaru Takeuchi11Department of Ophthalmology, National Defense Medical College, Saitama, Japan; 2Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, JapanBackground: Tocilizumab is a humanized monoclonal anti-interleukin-6 (IL-6 receptor antibody and has been approved in Japan for the treatment of Castleman's disease, rheumatoid arthritis (RA, and systemic juvenile idiopathic arthritis. Conjunctivitis and dry eye are known ocular adverse effects, but uveitis has not been reported.Case report: A 72-year-old woman had undergone bilateral cataract surgery without complications. Six months after the surgery, she was diagnosed with RA and treated with tocilizumab infusion every 4 weeks. However, severe malaise and dizziness occurred after the third tocilizumab infusion, and the treatment was suspended. Since the symptoms associated with RA had resolved, she was followed without any medication thereafter. At 5 weeks after the third tocilizumab infusion, she developed severe anterior inflammation with hypopyon in her left eye, and her visual acuity dropped to less than 2/200. Considering her age and history of cataract surgery, endophthalmitis was suspected and a vitrectomy was performed, but no pathogens were detected from the intraocular fluid samples collected during surgery. The ocular inflammation was gradually resolved with systemic antibiotics and corticosteroids. However, severe anterior uveitis recurred in the same eye during the tapering of the systemic corticosteroids, when the aqueous humor IL-6 level was 46,100 pg/mL. The recurrent ocular inflammation was resolved with increased doses of topical and systemic corticosteroids, and the patient has since remained relapse-free. No symptom of inflammation was observed in the right eye during the follow-up period.Conclusion: This case indicates a possibility that acute

  6. Differenziell exprimierte Proteine im Serum von Pferden mit equiner rezidivierender Uveitis

    OpenAIRE

    Zipplies, Johanna

    2008-01-01

    Die equine rezidivierende Uveitis (ERU) ist eine schubweise auftretende Augenentzündung, die 10% der Pferdepopulation betrifft. Die Entzündungsschübe führen im Verlauf der Erkrankung zur Erblindung des Pferdes. Die intraokuläre Entzündung ist durch autoreaktive T-Zellen gekennzeichnet. Trotz zahlreicher Untersuchungen sind weder die Ätiologie noch die Pathogenese dieser häufigen Erkrankung bislang eindeutig geklärt. Das Blut zirkuliert ständig im Körper und spiegelt dessen Zustand sehr gen...

  7. Clinical and visual outcomes of patients with uveitis in the mid-Atlantic United States

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    Bajwa A

    2015-09-01

    Full Text Available Asima Bajwa,1 Chang Sup Lee,1 Jim Patrie,2 Wenjun Xin,2 Ashvini K Reddy1 1Department of Ophthalmology, 2Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Purpose: To report the clinical outcomes of uveitis patients at the University of Virginia. Methods: Retrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014. Parametric and nonparametric methods were used to analyze the change in best-corrected visual acuity (BCVA in relation to demographics, diagnoses, management, and complications. Results: The study included 644 eyes of 491 patients. Patients with mild visual loss (logMAR <0.4 at presentation were younger than those with severe visual loss (SVL, logMAR >1.0 (P=0.002. Females were more likely to have mild visual loss as compared to males (P=0.025. Median overall BCVA was logMAR 0.18 at initial and final presentation (P=1.00. Vision loss at diagnosis was a predictor for moderate visual loss (MVL, logMAR 0.4 to <1.0 to SVL at last follow-up (P<0.001. Eyes with ocular hypertension were positively associated with MVL and SVL as compared to normotensive eyes (1.89 times at baseline, 2.62 times at last follow-up. Median BCVA was 0.18 logMAR for the anterior uveitis (AU and 0.48 logMAR for the non-AU patients (P<0.001. AU patients were less likely to have SVL than non-AU group (P<0.001. AU group received local corticosteroids more frequently and systemic corticosteroids less commonly than non-AU patients (P<0.001. AU patients with MVL to SVL were more likely to have ophthalmic surgery (cataract, glaucoma or pars plana vitrectomy [PPV] than those without MVL or SVL (P<0.001. Non-AU patients with MVL to SVL were more likely to have PPV than those without MVL or SVL (P=0.001. Conclusion: Mean overall BCVA remained stable. Favorable visual results were associated with younger age, female gender, and AU. Poor visual prognosis was concomitant with SVL at presentation

  8. Uveitis associated to the infection by Leishmania chagasi in dog from the Olinda city, Pernambuco, Brazil

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    Brito Fábio Luiz da Cunha

    2004-01-01

    Full Text Available Among the parasitic diseases, Canine Visceral Leishmaniasis (CVL is included in the systemic illnesses of chronic evolution that attack men and dogs, presenting varied clinical manifestations as cachexia, dermatologic lesions, peripheral lymphadenopathies, besides the ocular lesions. This work report the case of a dog clinically suspected of having CVL, presenting skin lesions, cachexia, gryphosis, and ocular signs of uveitis. The parasitological diagnosis was accomplished for Canine Leishmaniasis through the visualization of amastigote forms of Leishmania chagasi in smears of bone marrow fluid aspirate, of non-lesioned, and lesioned skin. Alterations in the ocular structures are characterized mainly by mononuclear-plasmocitic infiltrate.

  9. Uveíte na artrite idiopática juvenil Uveitis in juvenile idiopathic arthritis

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    Adriana M. Roberto

    2002-02-01

    üente na população de pacientes com AIJ associada com uveíte (60% do que naqueles sem uveíte (12% (pObjective: to evaluate the frequency of chronic anterior uveitis in patients with juvenile idiopathic arthritis and its association with the presence of antinuclear antibodies. Patients and methods: we retrospectively studied 72 patients with juvenile idiopathic arthritis. All of them were submitted to slit-lamp examination of the anterior chamber at diagnosis. Both antinuclear antibodies and rheumatoid factor were determined. Patients with positive results for antinuclear antibodies were evaluated every three months and those with negative results were assessed every six months.Results: forty patients were male (55.5% and 36 were Caucasoid (50%. The mean age at the onset of juvenile idiopathic arthritis was 6.4 years (range = 1 to 14 years and the mean age at the beginning of the study was 10.4 years (1 to 19 years. According to the type of disease at onset, 32 were pauciarticular (44.4% (17 boys and 15 girls, 30 were polyarticular (41.6% (17 boys and 13 girls and 10 were systemic (14% (6 boys and 4 girls. We observed chronic anterior uveitis in five patients (6.5% (mean age = 11.4 years. Among them, four (80% had pauciarticular juvenile idiopathic arthritis at disease onset (three girls with type I juvenile idiopathic arthritis and positive antinuclear antibodies and one boy with type I juvenile idiopathic arthritis and negative antinuclear antibodies and one girl with polyarticular juvenile idiopathic arthritis (negative antinuclear antibodies and rheumatoid factor. In this group, the mean age at the onset of juvenile idiopathic arthritis was 5.1 years and the mean age of uveitis onset was 9 years. Antinuclear antibodies were positive in 3/5 patients (60% with uveitis. Antinuclear antibodies were positive in 12% of the patients without uveitis (n = 67. Among the patients with uveitis, three had only one flare and the other two had four flares with cataract. The

  10. Sustained-release dexamethasone intravitreal implant in juvenile idiopathic arthritis-related uveitis.

    Science.gov (United States)

    Pichi, Francesco; Nucci, Paolo; Baynes, Kimberly; Lowder, Careen Y; Srivastava, Sunil K

    2017-02-01

    The purpose of this study is to review the results of treatment of juvenile idiopathic arthritis-related uveitis with the use of intravitreal dexamethasone implant. Sixteen eyes with Juvenile idiopathic arthritis (JIA)-associated uveitis received intravitreal dexamethasone implant to treat recalcitrant anterior segment inflammation (43.7 %), chronic macular edema (6.2 %), or a combination of both (50 %). One month after injection, mean visual acuity had improvement to 39.6 ± 11 ETDRS letters (p < 0.001). Mean AC cells measure at 1 month was 0.79 and 0.75 at 3 months. One month after injection, there was a significant reduction of central retinal thickness (CRT) to 342.4 ± 79.3 µm (p < 0.01). One month after the second implant, 11 eyes (91.6 %) achieved improved activity of the anterior uveitis, and mean best-corrected visual acuity improved to 44.6 ± 8.1 ETDRS letters (p < 0.01). At 1 month after the second injection, 4/5 eyes had resolution of macular edema with CRT of 250.4 ± 13.7 µm (p < 0.01). Of the 16 eyes, 12 eyes received a second injection at mean of 7.5 ± 3.1 months after the first treatment, and 5 eyes received a third Ozurdex injection on average 7 ± 4.6 months after the second injection. Of the 16 eyes, five eyes were pseudophakic prior to injection. Of the remaining 11 eyes, 8 (73 %) developed worsening posterior subcapsular cataract at a mean of 7.3 ± 1.2 months after the first injection. After the first injection, only one eye required topical antiglaucoma therapy with maximum pressure of 25 mmHg. In patients with recalcitrant JIA-associated active uveitis, injection of sustained-release dexamethasone can achieve control of anterior inflammation and resolution of macular edema.

  11. Acute anterior uveitis and other extra-articular manifestations of spondyloarthritis

    Science.gov (United States)

    Mitulescu, TC; Popescu, C; Naie, A; Predeţeanu, D; Popescu, V; Alexandrescu, C; Voinea, LM

    2015-01-01

    Background: Spondyloarthritis (SpA) is associated with an array of peripheral manifestations. Our study aims to evaluate extra-articular manifestations of SpA in a Romanian academic clinical setting and to observe their associations with different disease measures. Methods: The study was designed to note the extra-articular manifestations of SpA patients in a cross-sectional and retrospective manner. Records included demographics, inflammation markers, SpA clinical characteristics, treatment regimes, associated osteoporosis and cardiovascular morbidity. Data were assessed by using appropriate non-parametric tests. Results: A total of 126 SpA patients were included. The most common extra-articular manifestations were skin involvement in the form of psoriasis (34.1%), eye involvement in the form of acute anterior uveitis (8.7%) and dactylitis (7.2%). Compared to patients with no record of uveitis, uveitis-affected cases were more frequently males, more frequently diagnosed with ankylosing spondylitis, but less frequently dyslipidemic and diagnosed with psoriasis. Psoriasis-affected patients were older and had a higher prevalence of peripheral SpA diagnosis, but a lower prevalence of radiographic sacroiliitis. Conclusions:Acute anterior uveitis in SpA predominantly affects males with AS. This is relevant both to clinical and fundamental science, since its management requires both ophthalmology and rheumatology clinical settings. Psoriasis was associated more frequently with peripheral SpA. Abbreviations: AHT = arterial hypertension, AS = ankylosing spondylitis, ASAS = Assessment in SpondyloArthritis international Society, aSpA = axial spondyloarthritis, BASFI = Bath Ankylosing Spondylitis Functional Index, BASDAI = Bath Ankylosing Spondylitis Disease Activity Index, CRP = C-reactive protein, ESR = erythrocyte sedimentation rate, DM2 = type 2 diabetes mellitus, HLA = human leukocyte antigen, IBD = inflammatory bowel disease, MRI = magnetic resonance imaging, m

  12. Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis.

    Science.gov (United States)

    Cid, L; Pararajasegaram, G; Sevanian, A; Gauderman, W; Romero, J L; Marak, G E; Rao, N A

    1992-01-01

    The anti-phlogistic effect of dietary vitamin E supplementation on the acute inflammation observed in experimental lens-induced uveitis in Brown Norway rats was studied. The effects of vitamin E were examined using histopathologic parameters as well as by measuring the levels of arachidonic acid metabolites. Histologic examination of the eyes revealed that the vitamin E-deficient animals had the most severe destruction of the retina, while those animals receiving the vitamin E-supplemented diet exhibited the best preservation of the retinal architecture. Levels of arachidonic acid metabolites, as determined by radioimmunoassay, were significantly higher in vitamin E deficient rats as compared with rats on a normal diet.

  13. Dermatofitose canina causada pelo fungo antropofílico Trichophyton tonsurans - Relato de caso

    OpenAIRE

    Oliveira, Lorena Mayana Beserra de; Universidade Estadual do Ceará; Pinheiro, Adriana de Queiroz; Universidade Estadual do Ceará; Macedo, Iara Tersia Freitas; Universidade Estadual do Ceará; Silva, Isaac Neto Goes da; Universidade Estadual do Ceará; Moreira, Odanir Cruz; Universidade Estadual do Ceará; Silva, Bárbara Wilka Leal; Universidade Estadual do Ceará; Alencar, Érika Carvalho de; Universidade Estadual do Ceará; Leite, João Jaime Giffoni; Universidade Estadual do Ceará

    2015-01-01

    A dermatofitose é uma enfermidade cutânea de origem fúngica que merece destaque por sua elevada incidência na clínica de pequenos animais e importância na saúde animal e humana, pois pode ser transmitida do animal para o homem ou do homem para o animal. Este trabalho teve como objetivo relatar um caso de dermatofitose canina causado por uma espécie antropofílica de dermatófito, envolvendo o diagnóstico clínico e laboratorial. Uma cadela, da raça York Shire, com aproximadamente três anos de id...

  14. por valores

    Directory of Open Access Journals (Sweden)

    Jazmín Díaz-Barrios

    2005-01-01

    Full Text Available La era actual se caracteriza por una búsqueda de la identidad del hombre, donde el pivote del cambio organizacional es el individuo; cambiar en este entorno depende, en gran medida, de los valores que imperen en la cultura de la organización. Este trabajo documental intenta identificar aquellos valores, condición sine-qua-non, para el logro de los objetivos de cambio y analizarlos a fin de determinar sus indicadores, con el objeto de presentar una herramienta a las organizaciones que les facilite adaptarse a los nuevos tiempos. Se encontró que los valores: Delegación, Comunicación, Colaboración, Participación y Aprendizaje, son esenciales en los cambios integrales de esta era. Se determinaron 20 indicadores de su presencia. Se concluye que con esta información cada ente puede elaborar instrumentos que le permitan saber si los valores requeridos están presentes y en caso contrario tomar decisiones que alineen a la organización alrededor de los valores humanistas planteados, incrementando así las posibilidades de éxito en el proceso de cambio y por ende, las posibilidades de supervivencia en esta nueva época.

  15. Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis.

    Science.gov (United States)

    Zhang, Lingjun; Bell, Brent A; Yu, Minzhong; Chan, Chi-Chao; Peachey, Neal S; Fung, John; Zhang, Xiaoming; Caspi, Rachel R; Lin, Feng

    2016-03-01

    Recent studies have suggested that reagents inhibiting complement activation could be effective in treating T cell mediated autoimmune diseases such as autoimmune uveitis. However, the precise role of the complement anaphylatoxin receptors (C3a and C5a receptors) in the pathogenesis of autoimmune uveitis remains elusive and controversial. We induced experimental autoimmune uveitis in mice deficient or sufficient in both C3a and C5a receptors and rigorously compared their retinal phenotype using various imaging techniques, including indirect ophthalmoscopy, confocal scanning laser ophthalmoscopy, spectral domain optical coherence tomography, topical endoscopic fundus imaging, and histopathological analysis. We also assessed retinal function using electroretinography. Moreover, we performed Ag-specific T cell recall assays and T cell adoptive transfer experiments to compare pathogenic T cell activity between wild-type and knockout mice with experimental autoimmune uveitis. These experiments showed that C3a receptor/C5a receptor-deficient mice developed much less severe uveitis than did control mice using all retinal examination methods and that these mice had reduced pathogenic T cell responses. Our data demonstrate that both complement anaphylatoxin receptors are important for the development of experimental autoimmune uveitis, suggesting that targeting these receptors could be a valid approach for treating patients with autoimmune uveitis.

  16. Choque séptico por ehrliquiosis

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    Viviana Hernández-de Mezerville

    2007-04-01

    Full Text Available La ehrliquiosis humana es una infección zoonótica transmitida por "garrapatas duras" causada por Anaplasma sp y Ehrlichia sp. Puede presentarse como un cuadro pseudogripal con fiebre, malestar general, mialgias y cefalea o hasta un choque séptico con falla multiorgánica y muerte. La mitad de los pacientes requieren atención hospitalaria en algún momento y se reporta una mortalidad de hasta el 5% secundaria a enfermedades oportunistas o a hemorragias. El diagnóstico se puede sospechar visualizando las mórulas intracitoplasmáticas en las células afectadas en frotis de sangre periférica, y se confirma con serología, con cultivos o con detección molecular. El tratamiento de elección es la doxiciclina con buena respuesta clínica. Se reporta un caso probable de ehrliquiosis humana asociado a choque séptico y falla multiorgánica tratado exitosamente en el Hospital Dr. Rafael Angel Calderón Guardia.

  17. IMPACT OF THE THERAPY WITH TUMOR NECROSIS FACTOR α INHIBITORS ON THE FREQUENCY OF UVEITIS EXACERBATIONS IN PATIENTS WITH ANKYLOSING SPONDYLITIS

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    Alla A Godzenko

    2014-01-01

    Full Text Available The course of uveitis in patients with ankylosing spondylitis (AS does not always correlate with inflammation in the axial skeleton and peripheral joints. Effect of tumor necrosis factor α (TNFα inhibitors on uveitis has been insufficiently studied yet, unlike their effect on the peripheral joints and spine.Objective. To compare the frequency of uveitis attacks in patients with AS during treatment with TNFα inhibitors and the conventional anti-inflammatory therapy.Materials and Methods. The study included 48 patients with AS and recurrent uveitis treated with TNFα inhibitors: 25 – infliximab, 15 – adalimumab, 9 – etanercept; 7 patients received two or more drugs sequentially. Median [25th, 75th percentiles] of the treatment duration was 3 [3.5; 5] years. The duration of treatment since the first attack of uveitis until administration of TNFα inhibitors was 5 [5; 9.7] years. Eighteen patients received only nonsteroidal anti-inflammatory drugs (NSAIDs, 30 patients received NSAIDs and basic anti-inflammatory drugs (DMARDs, including sulfasalazine (n = 23, methotrexate (n = 4, and cyclosporine (n = 4.Results. The median number of uveitis exacerbations during the standard anti-inflammatory therapy was 1 [0.4; 3] per year; during treatment with TNFα inhibitors – 0 [0; 0.5] per year (p = 0.0007. In 19 of 48 patients (40%, no exacerbations of uveitis were registered during therapy with these drugs. The frequency of uveitis attacks in patients treated with infliximab decreased from 1 [0.2; 2.75] to 0.1 [0; 0.8] episodes per year (p = 0.002, adalimumab – from 1.75 [1; 4.5] to 0 [0; 0.07] (p = 0.04, etanercept – from 0.95 [0.5; 1.75] to 0 [0; 0.07] (p = 0.001.Conclusion. Administration of TNFα inhibitors significantly reduces the frequency of uveitis attacks in patients with AS.

  18. Identificación y cuantificación de los efectos y consecuencias de los impactos ambientales generados por la mineria de extracción de oro por lixiviación de cianuro. Caso Mineria Yanacocha SRL, en Cajamarca, Perú

    OpenAIRE

    Yacoub López, Cristina

    2007-01-01

    En el proyecto realizado se ha estudiado la situación de vulnerabilidad medioambiental, específicamente del recurso hídrico, causada por la empresa Minera Yanacocha S.R.L (MYSRL) situada en la región de Cajamarca, en el Perú. La empresa minera es origen de conflictos en relación al agua, por su situación (cabecera de cuatro cuencas hidrográficas) y por la contaminación en la cantidad y calidad de sus aguas percibida por la población local. Para conocer los posibles impactos del...

  19. Emerging Therapies for Noninfectious Uveitis: What May Be Coming to the Clinics

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    Jose R. Maya

    2014-01-01

    Full Text Available Corticosteroids along with other immunomodulatory therapies remain as the mainstay of treatment tor all patients with noninfectious uveitis (NIU. However, the systemic side effects associated with the long-term use of these drugs has encouraged the development of new therapeutic agents in recent times. This review article discusses upcoming therapeutic agents and drug delivery systems that are currently being used to treat patients with NIU. These agents mediate their actions by blocking specific pathways involved in the inflammatory process. Agents discussed in this review include full or recombinant monoclonal antibodies against interleukins such as IL-17 (secukinumab, IL-l (gevokizumab, and IL-6 (tocilizumab and sarilumab, antibody fragments against inflammatory cytokines such as TNF-α (ESBA 105 and T-cell inhibitors such as fusion proteins (abatacept, and next generation calcineurin inhibitors (voclosporin. In addition, administration of immune modulatory therapies using methods such as iontophoresis (EGP-437 and intravitreal injection (sirolimus for the treatment of NIU' uveitis has also been discussed.

  20. Structural modeling of a novel CAPN5 mutation that causes uveitis and neovascular retinal detachment.

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    Alexander G Bassuk

    Full Text Available CAPN5 mutations have been linked to autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, a blinding autoimmune eye disease. Here, we link a new CAPN5 mutation to ADNIV and model the three-dimensional structure of the resulting mutant protein. In our study, a kindred with inflammatory vitreoretinopathy was evaluated by clinical eye examinations, DNA sequencing, and protein structural modeling to investigate the disease-causing mutation. Two daughters of an affected mother demonstrated symptoms of stage III ADNIV, with posterior uveitis, cystoid macular edema, intraocular fibrosis, retinal neovascularization, retinal degeneration, and cataract. The women also harbored a novel guanine to thymine (c.750G>T, p.Lys250Asn missense mutation in exon 6 of CAPN5, a gene that encodes a calcium-activated cysteine protease, calpain-5. Modeling based on the structures of all known calpains revealed the mutation falls within a calcium-sensitive flexible gating loop that controls access to the catalytic groove. Three-dimensional modeling placed the new mutation in a region adjacent to two previously identified disease-causing mutations, all three of which likely disrupt hydrogen bonding within the gating loop, yielding a CAPN5 with altered enzymatic activity. This is the third case of a CAPN5 mutation leading to inherited uveitis and neovascular vitreoretinopathy, suggesting patients with ADNIV features should be tested for CAPN5 mutations. Structural modeling of novel variants can be used to support mechanistic consequences of the disease-causing variants.

  1. Intraperitoneal Infusion of Mesenchymal Stem/Stromal Cells Prevents Experimental Autoimmune Uveitis in Mice

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    Joo Youn Oh

    2014-01-01

    Full Text Available Autoimmune uveitis is one of the leading causes of blindness. We here investigated whether intraperitoneal administration of human mesenchymal stem/stromal cells (hMSCs might prevent development of experimental autoimmune uveitis (EAU in mice. Time course study showed that the number of IFN-γ- or IL-17-expressing CD4+ T cells was increased in draining lymph nodes (DLNs on the postimmunization day 7 and decreased thereafter. The retinal structure was severely disrupted on day 21. An intraperitoneal injection of hMSCs at the time of immunization protected the retina from damage and suppressed the levels of proinflammatory cytokines in the eye. Analysis of DLNs on day 7 showed that hMSCs decreased the number of Th1 and Th17 cells. The hMSCs did not reduce the levels of IL-1β, IL-6, IL-12, and IL-23 which are the cytokines that drive Th1/Th17 differentiation. Also, hMSCs did not induce CD4+CD25+Foxp3+ cells. However, hMSCs increased the level of an immunoregulatory cytokine IL-10 and the population of IL-10-expressing B220+CD19+ cells. Together, data demonstrate that hMSCs attenuate EAU by suppressing Th1/Th17 cells and induce IL-10-expressing B220+CD19+ cells. Our results support suggestions that hMSCs may offer a therapy for autoimmune diseases mediated by Th1/Th17 responses.

  2. Surgical management of equine recurrent uveitis with single port pars plana vitrectomy.

    Science.gov (United States)

    Frühauf, B.; Ohnesorge, B.; Deegen, E.; Boevé, M.

    1998-01-01

    Current information suggests that equine recurrent uveitis (ERU) is an immune-mediated reaction to infectious agents or to autologous ophthalmic tissue. Recurrences are associated with progression of irreversible ocular damage. This report describes the intraoperative technique, complications, and long-term results of 38 eyes in 35 horses with ERU that underwent pars plana vitrectomy. The majority of the horses were warm-blooded. Recurrence of ERU was prevented in 35 of the 38 eyes. Some horses, especially in patients with incipient cataracts, developed vision loss in postoperative, quiescent eyes which was usually associated with cataract formation. Vision was stable in 85% of all eyes that underwent vitrectomy. Pars plana vitrectomy in horses appears successful in interrupting the cycle of repeated episodes of ERU, and the subsequent globe destruction in the majority of eyes. Removal of uveitis-induced 'immunologic memory' in the vitreous by vitrectomy may reduce adverse interaction between the vitreous and the uveal tract, and therefore reduce the recurrence of ERU.

  3. [35 leptospira isolated from the vitreous body of 32 horses with recurrent uveitis (ERU)].

    Science.gov (United States)

    Brem, S; Gerhards, H; Wollanke, B; Meyer, P; Kopp, H

    1999-01-01

    130 vitreous samples, systematically collected in 1998 from 117 horses during vitrectomy, were cultured for the presence of leptospires. All horses suffered from equine recurrent uveitis (ERU), also known as periodic ophthalmia or moon blindness, and were treated surgically to combat painful attacks, and to preserve vision. In 35 out of 130 vitreous samples (35/130 = 26.9%), leptospires could be isolated. These isolates belong to the grippotyphosa serogroup (n = 31) and to the australis serogroup (n = 4). So, for the first time, leptospires were recovered from eyes in vivo in a large number of horses with ERU. Vitreous samples and one serum sample from each horse were also tested for leptospiral antibodies using the microscopic agglutination test (MAT). In 92 vitreous samples (92/130 = 70.7%) and 96 serum samples (96/117 = 82.0%) leptospiral antibodies were detected at a dilution of > 1:100. The presence of intact leptospires and specific antibodies in eyes affected with ERU demonstrates a local antibody production to leptospiral antigen. These results indicate an important etiological role of leptospires in equine recurrent uveitis.

  4. [Demonstration of intraocular leptospira in 4 horses suffering from equine recurrent uveitis (ERU)].

    Science.gov (United States)

    Brem, S; Gerhards, H; Wollanke, B; Meyer, P; Kopp, H

    1998-01-01

    Vitreous samples from 43 horses which underwent vitrectomy because of equine recurrent uveitis (ERU) were cultured for leptospires. Out of 4 vitreous samples (4/43 = 9%), leptospires could be isolated. In 3 cases, serovar grippotyphosa, and in one case, a serovar out of the serogroup Australis were identified. So for the first time, in several horses with ERU in vivo cultures of vitreous material were positive for leptospires. A strong evidence of association between leptospiral infection and uveitis is discussed for many years. In this investigation the leptospiral etiology is confirmed. Vitreous material from 42 and serum samples from 40 horses were tested for specific antibodies to leptospira by microagglutination test (MAT). In 34 vitreous samples (34/42 = 81%), leptospiral antibody titers of 1:50 or higher were detected. In 33 horses (33/40 = 83%) leptospiral antibody titers of 1:50 or higher could also be detected in the serum. Altogether, leptospiral antibodies were detected by the MAT in the serum and in the vitreous material of 39 of 43 horses (= 91%) subjected to vitrectomy. These results indicate, that ERU is probably often a sequel to systemic Leptospira interrogans infection. The presence of intact leptospires and specific antibodies in eyes affected with ERU indicates a local antibody production to leptospira organisms and/or their antigens.

  5. The Role of M. leprae Hsp65 Protein and Peptides in the Pathogenesis of Uveitis

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    Alessandra Gonçalves Commodaro

    2012-01-01

    Full Text Available Experimental autoimmune uveitis (EAU is a well established model for immune-mediated organ-specific disease. Our group has recently shown that the M. leprae Hsp65 aggravated the uveitis in mice; in the present study, we evaluated the action of M. leprae  K409A mutant protein and the synthetic peptides Leader pep and K409A pep (covering amino acids residues 352–371 of WT and K409A proteins of M. leprae Hsp65, resp. on the pathogenesis of EAU. Mice received the 161–180 IRBP peptide and B. pertussis toxin followed by the intraperitoneal inoculation of K409A protein or the Leader pep or K409A pep. The Leader pep aggravated the disease, but mice receiving the K409A pep did not develop the disease and presented an increase in IL-10 levels by spleen cells and a decrease in t