Lessons learned from ESA INTEGRAL: cataclysmic variables and blazars

Czech Academy of Sciences Publication Activity Database

Hudec, René; Gális, R.; Kocka, Matúš

2010-01-01

Roč. 81, č. 1 (2010), s. 320-325 ISSN 0037-8720. [Multifrequency behaviour of high energy cosmic sources. Vulcano, 25.05.2009-30.05. 2009] Institutional research plan: CEZ:AV0Z10030501 Keywords : high-energy sources * cataclysmic variables * INTEGRAL Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

CVcat: An interactive database on cataclysmic variables

Science.gov (United States)

Kube, J.; Gänsicke, B. T.; Euchner, F.; Hoffmann, B.

2003-06-01

CVcat is a database that contains published data on cataclysmic variables and related objects. Unlike in the existing online sources, the users are allowed to add data to the catalogue. The concept of an ``open catalogue'' approach is reviewed together with the experience from one year of public usage of CVcat. New concepts to be included in the upcoming AstroCat framework and the next CVcat implementation are presented. CVcat can be found at http://www.cvcat.org.

White-dwarf rotational equilibria in magnetic cataclysmic variable stars

Energy Technology Data Exchange (ETDEWEB)

Warner, B. (Cape Town Univ. (South Africa). Dept. of Astronomy Australian National Univ., Canberra (Australia). Dept. of Mathematics); Wickramasinghe, D.T. (Australian National Univ., Canberra (Australia). Dept. of Mathematics)

1991-02-01

The magnetic cataclysmic variable stars (polars, intermediate polars and DQ Her stars) are grouped about three lines in the orbital period-spin period diagram. This segregation is shown to be the consequence of competition between braking and accretion torques when combined with the effects of cyclical variations in rate of mass transfer. (author).

Far Ultraviolet Spectroscopic Explorer Spectroscopy of the Nova-Like Cataclysmic Variable BB Doradus

Science.gov (United States)

2008-06-27

which we have best-fit models in the parameter space, we use the infrared magnitudes J, H, and K from the Two Micron All Sky Survey ( 2MASS ) to assess the...in a high state with a visual red magnitude R ¼ 14:60 and a blue magnitude B ¼ 13:90 (whereas B 16:5 in the low state). The 2MASS IR apparent...therefore certainly larger than 300 pc, and most likely in the range of 500 pc. Since BB Dor was observed in a high state (with 2MASS ), it is likely

White dwarf models of supernovae and cataclysmic variables

International Nuclear Information System (INIS)

Nomoto, K.; Hashimoto, M.

1986-01-01

If the accreting white dwarf increases its mass to the Chandrasekhar mass, it will either explode as a Type I supernova or collapse to form a neutron star. In fact, there is a good agreement between the exploding white dwarf model for Type I supernovae and observations. We describe various types of evolution of accreting white dwarfs as a function of binary parameters (i.e,. composition, mass, and age of the white dwarf, its companion star, and mass accretion rate), and discuss the conditions for the precursors of exploding or collapsing white dwarfs, and their relevance to cataclysmic variables. Particular attention is given to helium star cataclysmics which might be the precursors of some Type I supernovae or ultrashort period x-ray binaries. Finally we present new evolutionary calculations using the updated nuclear reaction rates for the formation of O+Ne+Mg white dwarfs, and discuss the composition structure and their relevance to the model for neon novae. 61 refs., 14 figs

Observing cataclysmic variables and related objects with different techniques

Czech Academy of Sciences Publication Activity Database

Šimon, Vojtěch

2012-01-01

Roč. 83, č. 2 (2012), s. 675-682 ISSN 0037-8720. [Workshop on the golden age of cataclysmic variables and related objects /2./. Palermo , 09.09.2013-14.09.2013] R&D Projects: GA ČR GA205/08/1207 Institutional research plan: CEZ:AV0Z10030501 Keywords : X-rays * binaries * circumstellar matter Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

The intermediate-age pre-cataclysmic variables SDSS J172406+562003 and RE J2013+4002

Science.gov (United States)

Shimansky, V. V.; Borisov, N. V.; Nurtdinova, D. N.; Mitrofanova, A. A.; Vlasyuk, V. V.; Spiridonova, O. I.

2012-06-01

We have analyzed the physical status of the pre-cataclysmic variables SDSSJ172406+562003 and RE J2013+4002, which have evolved after their common-envelope stage a time t = 106-107 years. Spectroscopy and photometry of these systems were performed with the 6-m and 1-m telescopes of the Special Astrophysical Observatory. We demonstrate that emission lines in the spectra were formed solely by the reflection of radiation emitted by the white dwarfs on the surfaces of their cool companions, under conditions close to local thermodynamic equilibrium. These effects are also responsible for most of the objects' photometric variability amplitude. However, comparing the light curves of SDSS 172406 from different epochs, we find aperiodic brightness variations, probably due to spottedness of the surface of the secondary. Jointly analyzing the spectra, radial-velocity curves, and light curves of the pre-cataclysmic variables and modeling the reflection effects, we have derived their fundamental parameters. We demonstrate that the secondaries in these systems are consistent with evolutionary models for main-sequence stars and do not have the luminosity excesses characteristic of cool stars in young pre-cataclysmic variables.

On the masses of the white dwarfs in cataclysmic variables

International Nuclear Information System (INIS)

Livio, M.; Soker, N.

1984-01-01

The question of the masses of the white dwarfs in cataclysmic binaries is examined. It is shown that selection effects can explain an overabundance of massive white dwarfs in novae but not in dwarf novae. It is proposed that the spiralling-in process in the common envelope favours the formation of more massive white dwarfs A number of simplified spiralling-in calculations are performed. The calculations demonstrate that the probability of coalescence of the secondary with the primary core, or secondary dissipation, is higher in the case of a giant envelope than in the case of a super giant envelope. Consequently, binaries with primary core masses greater than approx. 0.7 Msolar masses (and thus massive white dwarf remnants), have a better chance of surviving common envelope evolution and are therefore better candidates for the formation of cataclysmic variables. (author)

Evolution and Outbursts of Cataclysmic Variables

Directory of Open Access Journals (Sweden)

S.-B. Qian

2015-02-01

Full Text Available Mass transfer and accretion are very important to understand the evolution and observational properties of cataclysmic variables (CVs. Due to the lack of an accretion disk, eclipsing profiles of polars are the best source to study the character of mass transfer in CVs. By analyzing long-term photometric variations in the eclipsing polar HU Aqr, the property of mass transfer and accretion are investigated. The correlation between the brightness state change and the variation of the ingress profile suggests that both the accretion hot spot and the accretion stream are produced instantaneously. The observations clearly show that it is the variation of mass transfer causing the brightness state changes that is a direct evidence of variable mass transfer in a CV. It is shown that it is the local dark-spot activity near the L1 point to cause the change of the mass transfer rather than the activity cycles of the cool secondary star. Our results suggest that the evolution of CVs is more complex than that predicted by the standard model and we should consider the effect of variable mass accretion in nova and dwarf nova outbursts.

Winds in cataclysmic variable stars

International Nuclear Information System (INIS)

Cordova, F.A.; Ladd, E.F.; Mason, K.O.

1984-01-01

Ultraviolet spectrophotometry of two dwarf novae, CN Ori and RX And, at various phases of their outburst cycles confirms that the far uv flux increases dramatically about 1-2 days after the optical outburst begins. At this time the uv spectral line profiles indicate the presence of a high velocity wind. The detectability of the wind depends more on the steepness of the spectrum, and thus on the flux in the extreme ultraviolet, than on the absolute value of the far uv luminosity. The uv continuum during outburst consists of (at least) two components, the most luminous of which is located behind the wind and is completely absorbed by the wind at the line frequencies. Several pieces of evidence suggest that the uv emission lines that are observed in many cataclysmic variables during quiescence have a different location in the binary than the wind, and are affected very little by the outburst

Cataclysmic variables as probes of x-ray properties of interstellar grains

International Nuclear Information System (INIS)

Bode, M.F.; Evans, A.; Norwell, G.A.

1983-01-01

Interstellar-grain properties have previously been probed at wavelengths ranging from the infrared to the ultraviolet. Recent work by other authors has shown that we may also observe the effects of scattering by such grains at x-ray wavelengths. In this paper we suggest that investigations of the x-ray properties of interstellar grains may profitably be conducted in sight lines to variable sources. Particular emphasis is given in this context to cataclysmic variables and related objects

The X-ray cataclysmic variable 1E0643.0-1648

International Nuclear Information System (INIS)

Bailey, J.; Hough, J.H.

1981-01-01

A new simultaneous IR/optical high-speed photometer on the UK IR telescope has been used to study the recently discovered cataclysmic variable 1 E0643.0-1648. The light curve shows it to be a dwarf nova with a recurrence time scale of 15 days. Photometry obtained during the decline from an outburst showed slow flickering, with the IR and optical curves correlated with no delay. (author)

White Dwarfs in Cataclysmic Variables: An Update

Directory of Open Access Journals (Sweden)

E. M. Sion

2015-02-01

Full Text Available In this review, we summarize what is currently known about the surface temperatures of accreting white dwarfs in nonmagnetic and magnetic cataclysmic variables (CVs based upon synthetic spectral analyses of far ultraviolet data. We focus only on white dwarf surface temperatures, since in the area of chemical abundances, rotation rates, WD masses and accretion rates, relatively little has changed since our last review, pending the results of a large HST GO programinvolving 48 CVs of different CV types. The surface temperature of the white dwarf in SS Cygni is re-examined in the light of its revised distance. We also discuss new HST spectra of the recurrent nova T Pyxidis as it transitioned into quiescence following its April 2011 nova outburst.

Cataclysmic variables from a ROSAT/2MASS selection - I. Four new intermediate polars

NARCIS (Netherlands)

Gänsicke, B.T.; Marsh, T.R.; Edge, A.; Rodríguez-Gil, P.; Steeghs, D.; Araujo-Betancor, S.; Harlaftis, E.; Giannakis, O.; Pyrzas, S.; Morales-Rueda, L.; Aungwerojwit, A.

2005-01-01

We report the first results from a new search for cataclysmic variables (CVs) using a combined X-ray (ROSAT)/infrared (2MASS) target selection that discriminates against background active galactic nuclei. Identification spectra were obtained at the Isaac Newton Telescope for a total of 174 targets,

Cataclysmic Variables as Supernova Ia Progenitors

Directory of Open Access Journals (Sweden)

Stella Kafka

2012-06-01

Full Text Available Although the identification of the progenitors of type Ia supernovae (SNeIa remains controversial, it is generally accepted that they originate from binary star systems in which at least one component is a carbon-oxygen white dwarf (WD; those systems are grouped under the wide umbrella of cataclysmic variables. Current theories for SNeIa progenitors hold that, either via Roche lobe overflow of the companion or via a wind, the WD accumulates hydrogen or helium rich material which is then burned to C and O onto the WD’s surface. However, the specifics of this scenario are far from being understood or defined, allowing for a wealth of theories fighting for attention and a dearth of observations to support them. I discuss the latest attempts to identify and study those controversial SNeIa progenitors. I also introduce the most promising progenitor in hand and I present observational diagnostics that can reveal more members of the category.

Visualizing SPH Cataclysmic Variable Accretion Disk Simulations with Blender

Science.gov (United States)

Kent, Brian R.; Wood, Matthew A.

2015-01-01

We present innovative ways to use Blender, a 3D graphics package, to visualize smoothed particle hydrodynamics particle data of cataclysmic variable accretion disks. We focus on the methods of shape key data constructs to increasedata i/o and manipulation speed. The implementation of the methods outlined allow for compositing of the various visualization layers into a final animation. The viewing of the disk in 3D from different angles can allow for a visual analysisof the physical system and orbits. The techniques have a wide ranging set of applications in astronomical visualization,including both observation and theoretical data.

Cataclysmic variables in the SUPERBLINK proper motion survey

Energy Technology Data Exchange (ETDEWEB)

Skinner, Julie N.; Thorstensen, John R. [Department of Physics and Astronomy, 6127 Wilder Laboratory, Dartmouth College, Hanover, NH 03755-3528 (United States); Lépine, Sébastien, E-mail: jns@dartmouth.edu [Department of Physics and Astronomy, Georgia State University, 25 Park Place NE, Atlanta, GA 30303 (United States)

2014-12-01

We have discovered a new high proper motion cataclysmic variable (CV) in the SUPERBLINK proper motion survey, which is sensitive to stars with proper motions greater than 40 mas yr{sup −1}. This CV was selected for follow-up observations as part of a larger search for CVs selected based on proper motions and their near-UV−V and V−K{sub s} colors. We present spectroscopic observations from the 2.4 m Hiltner Telescope at MDM Observatory. The new CV's orbital period is near 96 minutes, its spectrum shows the double-peaked Balmer emission lines characteristic of quiescent dwarf novae, and its V magnitude is near 18.2. Additionally, we present a full list of known CVs in the SUPERBLINK catalog.

The Golden Age of Cataclysmic Variables and Related Objects - II Concluding Address

Directory of Open Access Journals (Sweden)

F. Giovannelli

2015-02-01

Full Text Available Before to conclude officially this workshop — far from me the idea to attempt some concluding remarks already dealt at the meeting with various burning by Joseph Patterson, Mariko Kato, Dmitry Bisikalo, and Rene Hudec —, I would like to comment few highlights coming out from our fruitful week of discussions about The Golden Age of Cataclysmic Variables and Related Objects - II, without any pretension of completeness.

Exploratory Spectroscopy of Magnetic Cataclysmic Variables Candidates and Other Variable Objects

Energy Technology Data Exchange (ETDEWEB)

Oliveira, A. S.; Palhares, M. S. [IP and D, Universidade do Vale do Paraíba, 12244-000, São José dos Campos, SP (Brazil); Rodrigues, C. V.; Cieslinski, D.; Jablonski, F. J. [Divisão de Astrofísica, Instituto Nacional de Pesquisas Espaciais, 12227-010, São José dos Campos, SP (Brazil); Silva, K. M. G. [Gemini Observatory, Casilla 603, La Serena (Chile); Almeida, L. A. [Instituto de Astronomia, Geofísica e Ciências Atmosféricas, Universidade de São Paulo, 05508-900, São Paulo, SP (Brazil); Rodríguez-Ardila, A., E-mail: alexandre@univap.br [Laboratório Nacional de Astrofísica LNA/MCTI, 37504-364, Itajubá MG (Brazil)

2017-04-01

The increasing number of synoptic surveys made by small robotic telescopes, such as the photometric Catalina Real-Time Transient Survey (CRTS), provides a unique opportunity to discover variable sources and improves the statistical samples of such classes of objects. Our goal is the discovery of magnetic Cataclysmic Variables (mCVs). These are rare objects that probe interesting accretion scenarios controlled by the white-dwarf magnetic field. In particular, improved statistics of mCVs would help to address open questions on their formation and evolution. We performed an optical spectroscopy survey to search for signatures of magnetic accretion in 45 variable objects selected mostly from the CRTS. In this sample, we found 32 CVs, 22 being mCV candidates, 13 of which were previously unreported as such. If the proposed classifications are confirmed, it would represent an increase of 4% in the number of known polars and 12% in the number of known IPs. A fraction of our initial sample was classified as extragalactic sources or other types of variable stars by the inspection of the identification spectra. Despite the inherent complexity in identifying a source as an mCV, variability-based selection, followed by spectroscopic snapshot observations, has proved to be an efficient strategy for their discoveries, being a relatively inexpensive approach in terms of telescope time.

Astrometry with Hubble Space Telescope Fine Guidance Sensor 3: The Parallax of the Cataclysmic Variable RW Triangulum

Science.gov (United States)

McArthur, B. E.; Benedict, G. F.; Lee, J.; Lu, C.-L.; van Altena, W. F.; Deliyannis, C. P.; Girard, T.; Fredrick, L. W.; Nelan, E.; Duncombe, R. L.; Hemenway, P. D.; Jefferys, W. H.; Shelus, P. J.; Franz, O. G.; Wasserman, L. H.

1999-07-01

RW Triangulum (RW Tri) is a 13th magnitude nova-like cataclysmic variable star with an orbital period of 0.2319 days (5.56 hr). Infrared observations of RW Tri indicate that its secondary is most likely a late-K dwarf (Dhillon). Past analyses predicted a distance of 270 pc, derived from a blackbody fit to the spectrum of the central part of the disk (Rutten, van Paradijs, & Tinbergen). Recently completed Hubble Space Telescope Fine Guidance Sensor interferometric observations allow us to determine the first trigonometric parallax to RW Tri. This determination puts the distance of RW Tri at 341-31+38, one of the most distant objects with a direct parallax measurement. We compare our result with methods previously employed to estimate distances to cataclysmic variables.

Searching for nova shells around cataclysmic variables

Science.gov (United States)

Sahman, D. I.; Dhillon, V. S.; Knigge, C.; Marsh, T. R.

2015-08-01

We present the results of a search for nova shells around 101 cataclysmic variables (CVs), using H α images taken with the 4.2-m William Herschel Telescope (WHT) and the 2.5-m Isaac Newton Telescope Photometric H α Survey of the Northern Galactic Plane (IPHAS). Both telescopes are located on La Palma. We concentrated our WHT search on nova-like variables, whilst our IPHAS search covered all CVs in the IPHAS footprint. We found one shell out of the 24 nova-like variables we examined. The newly discovered shell is around V1315 Aql and has a radius of ˜2.5 arcmin, indicative of a nova eruption approximately 120 yr ago. This result is consistent with the idea that the high mass-transfer rate exhibited by nova-like variables is due to enhanced irradiation of the secondary by the hot white dwarf following a recent nova eruption. The implications of our observations for the lifetime of the nova-like variable phase are discussed. We also examined four asynchronous polars, but found no new shells around any of them, so we are unable to confirm that a recent nova eruption is the cause of the asynchronicity in the white dwarf spin. We find tentative evidence of a faint shell around the dwarf nova V1363 Cyg. In addition, we find evidence for a light echo around the nova V2275 Cyg, which erupted in 2001, indicative of an earlier nova eruption ˜300 yr ago, making V2275 Cyg a possible recurrent nova.

Measurement of the ratio Γbb/Γhad using event shape variables

Science.gov (United States)

Buskulic, D.; de Bonis, I.; Decamp, D.; Ghez, P.; Goy, C.; Lees, J.-P.; Minard, M.-N.; Pietrzyk, B.; Ariztizabal, F.; Comas, P.; Crespo, J. M.; Delfino, M.; Efthymiopoulos, I.; Fernandez, E.; Fernandez-Bosman, M.; Gaitan, V.; Garrido, Ll.; Mattison, T.; Pacheco, A.; Padilla, C.; Pascual, A.; Creanza, D.; de Palma, M.; Farilla, A.; Iaselli, G.; Maggi, G.; Natali, S.; Nuzzo, S.; Quattromini, M.; Ranieri, A.; Raso, G.; Romano, F.; Ruggieri, F.; Selvaggi, G.; Silvestris, L.; Tempesta, P.; Zito, G.; Chai, Y.; Hu, H.; Huang, D.; Huang, X.; Lin, J.; Wang, T.; Xie, Y.; Xie, D.; Xu, D.; Xu, R.; Zhang, J.; Zhang, L.; Zhao, W.; Blucher, E.; Bonvicini, G.; Boudreau, J.; Casper, D.; Drevermann, H.; Forty, R. W.; Ganis, G.; Gay, C.; Hagelberg, R.; Harvey, J.; Hilgart, J.; Jacobsen, R.; Jost, B.; Knobloch, J.; Lehraus, I.; Lohse, T.; Maggi, M.; Markou, C.; Martinez, M.; Mato, P.; Meinhard, H.; Minten, A.; Miotto, A.; Miquel, R.; Moser, H.-G.; Palazzi, P.; Pater, J. R.; Perlas, J. A.; Pusztaszeri, J.-F.; Ranjard, F.; Redlinger, G.; Rolandi, L.; Rothberg, J.; Ruan, T.; Saich, M.; Schlatter, D.; Schmelling, M.; Sefkow, F.; Tejessy, W.; Tomalin, I. R.; Veenhof, R.; Wachsmuth, H.; Wasserbaech, S.; Wiedenmann, W.; Wildish, T.; Witzeling, W.; Wotschack, J.; Ajaltouni, Z.; Badaud, F.; Bardadin-Otwinowska, M.; El Fellous, R.; Falvard, A.; Gay, P.; Guicheney, C.; Henrard, P.; Jousset, J.; Michel, B.; Montret, J.-C.; Pallin, D.; Perret, P.; Podlyski, F.; Proriol, J.; Prulhière, F.; Saadi, F.; Fearnley, T.; Hansen, J. B.; Hansen, J. D.; Hansen, J. R.; Hansen, P. H.; Møllerud, R.; Nilsson, B. S.; Kyriakis, A.; Simopoulou, E.; Siotis, I.; Vayaki, A.; Zachariadou, K.; Badier, J.; Blondel, A.; Bonneaud, G.; Brient, J. C.; Fouque, G.; Orteu, S.; Rougé, A.; Rumpf, M.; Tanaka, R.; Verderi, M.; Videau, H.; Candlin, D. J.; Parsons, M. I.; Veitch, E.; Focardi, E.; Moneta, L.; Parrini, G.; Corden, M.; Georgiopoulos, C.; Ikeda, M.; Levinthal, D.; Antonelli, A.; Baldini, R.; Bencivenni, G.; Bologna, G.; Bossi, F.; Campana, P.; Capon, G.; Cerutti, F.; Chiarella, V.; D'Ettorre-Piazzoli, B.; Felici, G.; Laurelli, P.; Mannocchi, G.; Murtas, F.; Murtas, G. P.; Passalacqua, L.; Pepe-Altarelli, M.; Picchi, P.; Colrain, P.; Ten Have, I.; Lynch, J. G.; Maitland, W.; Morton, W. T.; Raine, C.; Reeves, P.; Scarr, J. M.; Smith, K.; Smith, M. G.; Thompson, A. S.; Turnbull, R. M.; Brandl, B.; Braun, O.; Geweniger, C.; Hanke, P.; Hepp, V.; Kluge, E. E.; Maumary, Y.; Putzer, A.; Rensch, B.; Stahl, A.; Tittel, K.; Wunsch, M.; Beuselinck, R.; Binnie, D. M.; Cameron, W.; Cattaneo, M.; Colling, D. J.; Dornan, P. J.; Greene, A. M.; Hassard, J. F.; Lieske, N. M.; Moutoussi, A.; Nash, J.; Patton, S.; Payne, D. G.; Phillips, M. J.; San Martin, G.; Sedgbeer, J. K.; Wright, A. G.; Girtler, P.; Kuhn, D.; Rudolph, G.; Vogl, R.; Bowdery, C. K.; Brodbeck, T. J.; Finch, A. J.; Foster, F.; Hughes, G.; Jackson, D.; Keemer, N. R.; Nuttall, M.; Patel, A.; Sloan, T.; Snow, S. W.; Whelan, E. P.; Kleinknecht, K.; Raab, J.; Renk, B.; Sander, H.-G.; Schmidt, H.; Steeg, F.; Walther, S. M.; Wanke, R.; Wolf, B.; Bencheikh, A. M.; Benchouk, C.; Bonissent, A.; Carr, J.; Coyle, P.; Drinkard, J.; Etienne, F.; Nicod, D.; Papalexiou, S.; Payre, P.; Roos, L.; Rousseau, D.; Schwemling, P.; Talby, M.; Adlung, S.; Assmann, R.; Bauer, C.; Blum, W.; Brown, D.; Cattaneo, P.; Dehning, B.; Dietl, H.; Dydak, F.; Frank, M.; Halley, A. W.; Jakobs, K.; Lauber, J.; Lütjens, G.; Lutz, G.; Männer, W.; Richter, R.; Schröder, J.; Schwarz, A. S.; Settles, R.; Seywerd, H.; Stierlin, U.; Stiegler, U.; St. Denis, R.; Wolf, G.; Alemany, R.; Boucrot, J.; Callot, O.; Cordier, A.; Davier, M.; Duflot, L.; Grivaz, J.-F.; Heusse, Ph.; Jaffe, D. E.; Janot, P.; Kim, D. W.; Le Diberder, F.; Lefrançois, J.; Lutz, A.-M.; Schune, M.-H.; Veillet, J.-J.; Videau, I.; Zhang, Z.; Abbaneo, D.; Bagliesi, G.; Batignani, G.; Bottigli, U.; Bozzi, C.; Calderini, G.; Carpinelli, M.; Ciocci, M. A.; dell'Orso, R.; Ferrante, I.; Fidecaro, F.; Foà, L.; Forti, F.; Giassi, A.; Giorgi, M. A.; Gregorio, A.; Ligabue, F.; Lusiani, A.; Mannelli, E. B.; Marrocchesi, P. S.; Messineo, A.; Palla, F.; Rizzo, G.; Sanguinetti, G.; Spagnolo, P.; Steinberger, J.; Tenchini, R.; Tonelli, G.; Triggiani, G.; Vannini, C.; Venturi, A.; Verdini, P. G.; Walsh, J.; Betteridge, A. P.; Gao, Y.; Green, M. G.; March, P. V.; Mir, Ll. M.; Medcalf, T.; Quazi, I. S.; Strong, J. A.; West, L. R.; Botterill, D. R.; Clifft, R. W.; Edgecock, T. R.; Haywood, S.; Norton, P. R.; Thompson, J. C.; Bloch-Devaux, B.; Colas, P.; Duarte, H.; Emery, S.; Kozanecki, W.; Lançon, E.; Lemaire, M. C.; Locci, E.; Marx, B.; Perez, P.; Rander, J.; Renardy, J.-F.; Rosowsky, A.; Roussarie, A.; Schuller, J.-P.; Schwindling, J.; Si Mohand, D.; Vallage, B.; Johnson, R. P.; Litke, A. M.; Taylor, G.; Wear, J.; Ashman, J. G.; Babbage, W.; Booth, C. N.; Buttar, C.; Cartwright, S.; Combley, F.; Dawson, I.; Thompson, L. F.; Barberio, E.; Böhrer, A.; Brandt, S.; Cowan, G.; Grupen, C.; Lutters, G.; Rivera, F.; Schäfer, U.; Smolik, L.; Bosisio, L.; della Marina, R.; Giannini, G.; Gobbo, B.; Ragusa, F.; Bellantoni, L.; Chen, W.; Conway, J. S.; Feng, Z.; Ferguson, D. P. S.; Gao, Y. S.; Grahl, J.; Harton, J. L.; Hayes, O. J.; Nachtman, J. M.; Pan, Y. B.; Saadi, Y.; Schmitt, M.; Scott, I.; Sharma, V.; Shi, Z. H.; Turk, J. D.; Walsh, A. M.; Weber, F. V.; Lan Wu, Sau; Wu, X.; Zheng, M.; Zobernig, G.

1993-09-01

The branching fraction of Z --> bb relative to all hadronic decays of the Z has been measured using event shape variables to preferentially select Z --> bb events. The method chosen applies a combination of shape discriminators and the selection of high transverse momentum leptons to event hemispheres. From a sample of 440 000 hadronic Z decays collected with the ALEPH detector at LEP, the ration Γbb/Γhad = 0.228+/-0.005(stat.)+/-0.005(syst.) is measured. Supported by the US Department of Energy, contract DE-AC02-76ER00881.

CATACLYSMIC VARIABLES FROM SDSS. VII. THE SEVENTH YEAR (2006)

International Nuclear Information System (INIS)

Szkody, Paula; Anderson, Scott F.; Hayden, Michael; Kronberg, Martin; McGurk, Rosalie; Riecken, Thomas; Schmidt, Gary D.; West, Andrew A.; Gaensicke, Boris T.; Gomez-Moran, Ada N.; Schwope, Axel D.; Schneider, Donald P.; Schreiber, Matthias R.

2009-01-01

Coordinates, magnitudes, and spectra are presented for 39 cataclysmic variables (CVs) found in Sloan Digital Sky Survey (SDSS) spectra that were primarily obtained in 2006. Of these, 13 were CVs identified prior to the SDSS spectra (AK Cnc, GY Cnc, GO Com, ST LMi, NY Ser, MR Ser, QW Ser, EU UMa, IY UMa, HS1340+1524, RXJ1610.1+0352, Boo 1, Leo 5). Follow-up spectroscopic observations of seven systems (including one from year 2005 and another from year 2004) were obtained, resulting in estimates of the orbital periods for three objects. The new CVs include two candidates for high inclination, eclipsing systems, four new polars, and three systems whose spectra clearly reveal atmospheric absorption lines from the underlying white dwarf.

The evolution of polar caps in magnetic cataclysmic variables

International Nuclear Information System (INIS)

Frank, J.; Chanmugam, G.

1986-01-01

A simple analysis of the evolution of the size of the magnetic polar cap in accreting white dwarfs is made on the basis of current theories of the secular evolution of magnetic cataclysmic variables. For white dwarfs with dipolar fields it is shown that the size of the polar cap in DQ Her binaries is larger than in AM Her binaries. The size of the former is, however, smaller than deduced from interpretation of their X-ray light curves, while that of the latter is in rough agreement. If the dwarf contains an aligned magnetic quadrupole the size of the polar caps of the DQ Her binaries is significantly increased. Magnetic field decay of the quadrupole moment in the older AM Her binaries implies that their fields are predominantly dipolar. (author)

SWSex Stars, Old Novae, and the Evolution of Cataclysmic Variables

Directory of Open Access Journals (Sweden)

L. Schmidtobreick

2015-02-01

Full Text Available The population of cataclysmic variables with orbital periods right above the period gap are dominated by systems with extremely high mass transfer rates, the so-called SW Sextantis stars. On the other hand, some old novae in this period range which are expected to show high mass transfer rate instead show photometric and/or spectroscopic resemblance to low mass transfer systems like dwarf novae. We discuss them as candidates for so-called hibernating systems, CVs that changed their mass transfer behaviour due to a previously experienced nova outburst. This paper is designed to provide input for further research and discussion as the results as such are still very preliminary.

White Dwarfs in Cataclysmic Variable Stars: Surface Temperatures and Evolution

Directory of Open Access Journals (Sweden)

Edward M. Sion

2012-06-01

Full Text Available A summary is presented of what is currently known about the surface temperatures of accreting white dwarfs (WDs detected in non-magnetic and magnetic cataclysmic variables (CVs based upon synthetic spectral analyses of far ultraviolet data. A special focus is placed on WD temperatures above and below the CV period gap as a function of the orbital period, Porb. The principal uncertainty of the temperatures for the CV WDs in the Teff - Porb distribution, besides the distance to the CV, is the mass of the WD. Only in eclipsing CV systems, an area of eclipsing binary studies, which was so central to Robert H. Koch’s career, is it possible to know CV WD masses with high precision.

Study of the eclipses of cataclysmic variables

International Nuclear Information System (INIS)

Zhang, E.H.

1986-01-01

The cataclysmic variables (CV's) are all close binary stars in which a secondary star fills its Roche lobe and transfers mass to its white dwarf companion. The transferred mass forms an accretion disk or ring, around the white dwarf. Reliable determinations of the masses of the two-component stars, the distributions of temperature and brightness across the disk, and other parameters, are necessary to understand both the CV's and the accretion processes, but they are extremely difficult to measure. The best way to obtain this data is to observe eclipsing CV's. The author developed a computer program to synthesize light curves of eclipsing CV's using the most realistic model built so far to analyze the eclipses of CV's. A statistical method was developed to perform a complete error analysis of the results of the numerical studies. High-speed, multi-color photometry of three eclipsing CV's - HT Cas, U Gem, and AC Cnc - was obtained. Using the program to analyze the observed light curves, the author derived, for each system, the orbital inclination, the sizes, masses and temperature of the two component stars, and the temperature distribution across the disk

SPECTROSCOPY OF NEW AND POORLY KNOWN CATACLYSMIC VARIABLES IN THE KEPLER FIELD

International Nuclear Information System (INIS)

Howell, Steve B.; Still, Martin; Everett, Mark E.; Seebode, Sally A.; Szkody, Paula; Wood, Matt; Ramsay, Gavin; Cannizzo, John; Smale, Alan

2013-01-01

The NASA Kepler mission has been in science operation since 2009 May and is providing high precision, high cadence light curves of over 150,000 targets. Prior to launch, nine cataclysmic variables were known to lie within Kepler's field of view. We present spectroscopy for seven systems, four of which were newly discovered since launch. All of the stars presented herein have been observed by, or are currently being observed by, the Kepler space telescope. Three historic systems and one new candidate could not be detected at their sky position and two candidates are called into question as to their true identity.

Exploratory Spectroscopy of Magnetic Cataclysmic Variables Candidates and Other Variable Objects

Science.gov (United States)

Oliveira, A. S.; Rodrigues, C. V.; Cieslinski, D.; Jablonski, F. J.; Silva, K. M. G.; Almeida, L. A.; Rodríguez-Ardila, A.; Palhares, M. S.

2017-04-01

The increasing number of synoptic surveys made by small robotic telescopes, such as the photometric Catalina Real-Time Transient Survey (CRTS), provides a unique opportunity to discover variable sources and improves the statistical samples of such classes of objects. Our goal is the discovery of magnetic Cataclysmic Variables (mCVs). These are rare objects that probe interesting accretion scenarios controlled by the white-dwarf magnetic field. In particular, improved statistics of mCVs would help to address open questions on their formation and evolution. We performed an optical spectroscopy survey to search for signatures of magnetic accretion in 45 variable objects selected mostly from the CRTS. In this sample, we found 32 CVs, 22 being mCV candidates, 13 of which were previously unreported as such. If the proposed classifications are confirmed, it would represent an increase of 4% in the number of known polars and 12% in the number of known IPs. A fraction of our initial sample was classified as extragalactic sources or other types of variable stars by the inspection of the identification spectra. Despite the inherent complexity in identifying a source as an mCV, variability-based selection, followed by spectroscopic snapshot observations, has proved to be an efficient strategy for their discoveries, being a relatively inexpensive approach in terms of telescope time. Based on observations obtained at the Observatório do Pico dos Dias/LNA, and at the Southern Astrophysical Research (SOAR) telescope, which is a joint project of the Ministério da Ciência, Tecnologia, e Inovação (MCTI) da República Federativa do Brasil, the U.S. National Optical Astronomy Observatory (NOAO), the University of North Carolina at Chapel Hill (UNC), and Michigan State University (MSU).

SPECTROSCOPY OF NEW AND POORLY KNOWN CATACLYSMIC VARIABLES IN THE KEPLER FIELD

Energy Technology Data Exchange (ETDEWEB)

Howell, Steve B.; Still, Martin [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Everett, Mark E. [National Optical Astronomy Observatory, 950 North Cherry Avenue, Tucson, AZ 85719 (United States); Seebode, Sally A. [San Mateo High School, San Mateo, CA 94401 (United States); Szkody, Paula [Astronomy Department, University of Washington, Seattle, WA 98195 (United States); Wood, Matt [Physics and Astronomy Department, Texas A and M University-Commerce, Commerce, TX 75429 (United States); Ramsay, Gavin [Armagh Observatory, College Hill, Armagh BT61 9DG (United Kingdom); Cannizzo, John [CRESST and Astroparticle Physics Laboratory, NASA/GSFC, Greenbelt, MD 20771 (United States); Smale, Alan [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

2013-04-15

The NASA Kepler mission has been in science operation since 2009 May and is providing high precision, high cadence light curves of over 150,000 targets. Prior to launch, nine cataclysmic variables were known to lie within Kepler's field of view. We present spectroscopy for seven systems, four of which were newly discovered since launch. All of the stars presented herein have been observed by, or are currently being observed by, the Kepler space telescope. Three historic systems and one new candidate could not be detected at their sky position and two candidates are called into question as to their true identity.

Eclipses of cataclysmic variables. II. U Geminorum

International Nuclear Information System (INIS)

Zhang, E.H.; Robinson, E.L.

1987-01-01

U Gem is an eclipsing dwarf nova with an orbital period of 4 h 15 m. High-speed, multicolor photometric observations of U Gem in its quiescent state were obtained. A program was used that synthesizes the light curves of cataclysmic variables to derive the properties of U Gem from its eclipses. Using radial velocity curves published by Wade (1981) and by Stover (1981), it was found that i = 69.7 + or - 0.7 deg, M1 = 1.12 + or - 0.13 solar masses, and M2 = 0.53 + or - 0.06 solar mass. The radial temperature distribution across the accretion disk in U Gem shows that the disk is a hollow ring around the white dwarf with R(out) = 0.30 + or - 0.04 and R(in) = 0.12 + or - 0.05 a, where a is the separation of the two stars. The temperature of the ring is 4800 + or - 300 K. The model also reproduces the published infrared light curves and ultraviolet spectral distributions of U Gem. A mass transfer rate of 7.8 x 10 to the -10th solar mass/yr is derived. The structure of the ring around the white dwarf is consistent with the current theories of accretion disk instabilities in dwarf novae. 39 references

Investigations of a New Eclipsing Cataclysmic Variable HBHA 4705-03

Science.gov (United States)

Yakin, D. G.; Suleimanov, V. F.; Shimansky, V. V.; Vlasyuk, V. V.; Spiridonova, O. I.

2013-01-01

Results of photometric and spectroscopic investigations of the recently discovered eclipsing cataclysmic variable star HBHA 4705-03 are presented. The emission spectra of the system show broad hydrogen and helium emission lines. The bright spots with an approximately zero velocity components are found in the Doppler maps for the hydrogen and ionized helium lines. The disc structure is more prominent in the maps for the neutral helium lines. The masses of the components (MWD = 0.54 ± 0.10M⊙ and MRD = 0.45 ± 0.05 M⊙), and the orbit inclination (i = 71.°8 ± 0.°7) were estimated using the radial velocity light curve and the eclipse width. The modeling of the light curve allows us to evaluate the bright spot parameters and the mass accretion rate (M ≍ 2 ·1017 g s-1).

SPECTROSCOPIC ORBITAL PERIODS FOR 29 CATACLYSMIC VARIABLES FROM THE SLOAN DIGITAL SKY SURVEY

Energy Technology Data Exchange (ETDEWEB)

Thorstensen, John R.; Taylor, Cynthia J.; Peters, Christopher S.; Skinner, Julie N. [Department of Physics and Astronomy 6127 Wilder Laboratory, Dartmouth College Hanover, NH 03755-3528 (United States); Southworth, John [Astrophysics Group Keele University Staffordshire ST5 5BG (United Kingdom); Gänsicke, Boris T. [Department of Physics University of Warwick Coventry CV4 7AL (United Kingdom)

2015-04-15

We report follow-up spectroscopy of 29 cataclysmic variables from the Sloan Digital Sky Survey (SDSS), 22 of which were discovered by SDSS and seven of which are previously known systems that were recovered in SDSS. The periods for 16 of these objects were included in the tabulation by Gänsicke et al. While most of the systems have periods less than 2 hr, only one has a period in the 80–86 minutes “spike” found by Gänsicke et al., and 11 have periods longer than 3 hr, indicating that the present sample is skewed toward longer-period, higher-luminosity objects. Seven of the objects have spectra resembling dwarf novae, but have apparently never been observed in outburst, suggesting that many cataclysmics with relatively low variability amplitude remain to be discovered. Some of the objects are notable. SDSS J07568+0858 and SDSS J08129+1911 were previously known to have deep eclipses; in addition to spectroscopy, we use archival data from the Catalina Real Time Transient Survey to refine their periods. We give a parallax-based distance of 195 (+54, −39) pc for LV Cnc (SDSS J09197+0857), which at P{sub orb} = 81 m has the shortest orbital period in our sample. SDSS J08091+3814 shows both the spectroscopic phase offset and phase-dependent absorption found in SW Sextantis stars. The average spectra of SDSS J08055+0720 and SDSS J16191+1351 show contributions from K-type secondaries, and SDSS J080440+0239 shows a contribution from an early M star. We use these to constrain the distances. SDSS J09459+2922 has characteristics typical of a magnetic system. SDSS11324+6249 may be a novalike variable, and if so, its orbital period (99 minutes) is unusually short for that subclass.

X-Ray Emission of Cataclysmic Variables Observed by Integral

Czech Academy of Sciences Publication Activity Database

Gális, R.; Eckert, D.; Paltani, S.; Münz, F.; Kocka, Matúš

2009-01-01

Roč. 18, 3-4 (2009), s. 321-326 ISSN 1392-0049 Grant - others:ESA(XE) ESA- PECS project No. 98023; VEGA(SK) 2/0078/10 Institutional research plan: CEZ:AV0Z10030501 Keywords : binaries starss * cataclysmic * X-rays Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.032, year: 2009

VHE gamma-rays from radio pulsars and cataclysmic variables

International Nuclear Information System (INIS)

De Jager, O.C.; Brink, C.; Meintjies, P.J.; Nel, H.I.; North, A.R.; Raubenheimer, B.C.; Van der Walt, D.J.

1990-01-01

We present the results of observations (above 1 TeV) of radio pulsars and cataclysmic variables with the Potchefstroom air Cerenkov facility. We were able to confirm our previous detection of PSR 1509-58 and the final significance is 1.7x10 -5 . A DC enhancement at the 10 -3 significance level was seen from the L 4 Lagrange position in the PSR 1957+20 system. This result was confirmed by COS-B data. We were also able to detect the 5.4 ms pulsar PSR 1855+09 at a marginal significance level of 5%. However, the best and longest observation indicates non-uniformity at the 0.005 significance level. The TeV light curve resembles the radio light curve. The latter is also reminiscent of other millisecond pulsar observed above 1 TeV. The intermediate polar AEAQR (P = 33.08s) shows a period shift which is consistent with recent model predictions. However, the present significance of this results does not allow an unambiguous claim. (orig.)

Features of the mass transfer in magnetic cataclysmic variables with fast-rotating white dwarfs

Directory of Open Access Journals (Sweden)

Isakova Polina

2014-01-01

Full Text Available The flow structure in magnetic cataclysmic variables was investigated taking into account the effects of strong magnetic field and fast rotation of the white dwarf. We modeled the AE Aqr system as a unique object that has the rotation period of the white dwarf is about 1000 times shorter than the orbital period of the binary system. Observations show that in spite of fast rotation of the white dwarf some part of the stream from the inner Lagrange point comes into the Roche lobe region. We analyzed possible mechanisms preventing material to outflow from the system.

Follow-up Observations of SDSS and CRTS Candidate Cataclysmic Variables II

Science.gov (United States)

Szkody, Paula; Everett, Mark E.; Dai, Zhibin; Serna-Grey, Donald

2018-01-01

Spectra of 38 candidate or known cataclysmic variables are presented. Most are candidate dwarf novae or systems containing possible highly magnetic white dwarfs, while a few (KR Aur, LS Peg, V380 Oph, and V694 Mon) are previously known objects caught in unusual states. Individual spectra are used to confirm a dwarf nova nature or other classification while radial velocities of 15 systems provide orbital periods and velocity amplitudes that aid in determining the nature of the objects. Our results substantiate a polar nature for four objects, find an eclipsing SW Sex star below the period gap, another as a likely intermediate polar, as well as two dwarf novae with periods in the middle of the gap. Based on observations obtained with the Apache Point Observatory (APO) 3.5 m telescope, which is owned and operated by the Astrophysical Research Consortium (ARC).

Dynamics of Line-Driven Winds from Disks in Cataclysmic Variables. I. Solution Topology and Wind Geometry

OpenAIRE

Feldmeier, Achim; Shlosman, Isaac

1999-01-01

We analyze the dynamics of 2-D stationary, line-driven winds from accretion disks in cataclysmic variable stars. The driving force is that of line radiation pressure, in the formalism developed by Castor, Abbott & Klein for O stars. Our main assumption is that wind helical streamlines lie on straight cones. We find that the Euler equation for the disk wind has two eigenvalues, the mass loss rate and the flow tilt angle with the disk. Both are calculated self-consistently. The wind is characte...

Hydrodynamic simulations of accretion disks in cataclysmic variables

International Nuclear Information System (INIS)

Hirose, Masahito; Osaki, Yoji

1990-01-01

The tidal effects of secondary stars on accretion disks in cataclysmic variables are studied by two-dimensional hydrodynamical simulations. The time evolution of an accretion disk under a constant mass supply rate from the secondary is followed until it reaches a quasi-steady state. We have examined various cases of different mass ratios of binary systems. It is found that the accretion disk settles into a steady state of an elongated disk fixed in the rotating frame of the binary in a binary system with comparable masses of component stars. On the other hand, in the case of a low-mass secondary, the accretion disk develops a non-axisymmetric (eccentric) structure and finally settles into a periodically oscillating state in which a non-axisymmetric eccentric disk rotates in the opposite direction to the orbital motion of the binary in the rotating frame of the binary. The period of oscillation is a few percent longer than the orbital period of the binary, and it offers a natural explanation for the ''superhump'' periodicity of SU UMa stars. Our results thus confirm basically those of Whitehurst (1988, AAA 45.064.032) who discovered the tidal instability of an accretion disk in the case of a low-mass secondary. We then discuss the cause of the tidal instability. It is shown that the tidal instability of accretion disks is caused by a parametric resonance between particle orbits and an orbiting secondary star with a 1:3 period ratio. (author)

Follow up observations of SDSS and CRTS candidate cataclysmic variables

Energy Technology Data Exchange (ETDEWEB)

Szkody, Paula; Vasquez-Soltero, Stephanie [Department of Astronomy, University of Washington, P.O. Box 351580, Seattle, WA 98195 (United States); Everett, Mark E.; Silva, David R. [National Optical Astronomy Observatory, 950 North Cherry Avenue, Tucson, AZ 85719 (United States); Howell, Steve B. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Landolt, Arlo U. [Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803 (United States); Bond, Howard E., E-mail: szkody@astro.washington.edu, E-mail: dsilva@noao.edu, E-mail: steve.b.howell@nasa.gov, E-mail: landolt@rouge.phys.lsu.edu, E-mail: heb11@psu.edu [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States)

2014-10-01

We present photometry and spectroscopy of 11 and 35 potential cataclysmic variables, respectively, from the Sloan Digital Sky Survey, the Catalina Real-Time Transient Survey, and vsnet alerts. The photometry results include quasi-periodic oscillations during the decline of V1363 Cyg, nightly accretion changes in the likely Polar (AM Herculis binary) SDSS J1344+20, eclipses in SDSS J2141+05 with an orbital period of 76 ± 2 minutes, and possible eclipses in SDSS J2158+09 at an orbital period near 100 minutes. Time-resolved spectra reveal short orbital periods near 80 minutes for SDSS J0206+20, 85 minutes for SDSS J1502+33, and near 100 minutes for CSS J0015+26, RXS J0150+37, SDSS J1132+62, SDSS J2154+15, and SDSS J2158+09. The prominent He II line and velocity amplitude of SDSS J2154+15 are consistent with a Polar nature for this object, while the absence of this line and a low velocity amplitude argue against this classification for RXS J0150+37. Single spectra of 10 objects were obtained near outburst and the rest near quiescence, confirming the dwarf novae nature of these objects.

Discovery of a New Classical Nova Shell Around a Nova-like Cataclysmic Variable

Science.gov (United States)

Guerrero, Martín A.; Sabin, Laurence; Tovmassian, Gagik; Santamaría, Edgar; Michel, Raul; Ramos-Larios, Gerardo; Alarie, Alexandre; Morisset, Christophe; Bermúdez Bustamante, Luis C.; González, Chantal P.; Wright, Nick J.

2018-04-01

The morphology and optical spectrum of IPHASX J210204.7+471015, a nebula classified as a possible planetary nebula are, however, strikingly similar to those of AT Cnc, a classical nova shell around a dwarf nova. To investigate its true nature, we have obtained high-resolution narrowband [O III] and [N II] images and deep optical spectra. The nebula shows an arc of [N II]-bright knots notably enriched in nitrogen, while an [O III]-bright bow shock is progressing throughout the ISM. Diagnostic line ratios indicate that shocks are associated with the arc and bow shock. The central star of this nebula has been identified by its photometric variability. Time-resolved photometric and spectroscopic data of this source reveal a period of 4.26 hr, which is attributed to a binary system. The optical spectrum is notably similar to that of RW Sex, a cataclysmic variable star (CV) of the UX UMa nova-like (NL) type. Based on these results, we propose that IPHASX J210204.7 + 471015 is a classical nova shell observed around a CV-NL system in quiescence.

Theoretical, numerical and experimental study of accretion shocks dynamics in magnetic cataclysmic variables

International Nuclear Information System (INIS)

Busschaert, Clotilde

2013-01-01

Magnetic cataclysmic variables are interacting binary Systems containing a highly magnetized white dwarf which accretes material from a companion. Material is led along magnetic field lines and falls onto the magnetic pole(s) supersonically forming an accretion column. As the material hits the surface, a reverse shock is formed and the shocked region is structured by the cooling effect of radiation processes. This work is a multidisciplinary study of the dynamics of the accretion column. Firstly, a numerical study of the accretion column structure at the astrophysical scale is presented. The observational consequences are discussed. This approach is completed by experiments using radiative flows generated by powerful lasers. The relevance of such experiments is based on the establishment of scaling laws. News scaling laws in the frame of radiative ideal or resistive MHD are exposed. The results of the sizing and the interpretation of the POLAR experimental campaign of 2012 on LULI2000 installation are presented. (author) [fr

Period changes of cataclysmic variables below the period gap: V2051 Oph, OY Car and Z Cha

Science.gov (United States)

Pilarčík, L.; Wolf, M.; Zasche, P.; Vraštil, J.

2018-04-01

We present our results of a long-term monitoring of cataclysmic variable stars (CVs). About 40 new eclipses were measured for the three southern SU UMa-type eclipsing CVs: V2051 Oph, OY Car and Z Cha. Based on the current O - C diagrams we confirmed earlier findings that V2051 Oph and OY Car present cyclic changes of their orbital periods lasting 25 and 29 years, respectively. In case of Z Cha we propose the light-time effect caused probably by a presence of the third component orbiting the eclipsing CV with the period of 43.5 years. The minimal mass of this companion results about 15 MJup.

DISCOVERY OF A NOVA-LIKE CATACLYSMIC VARIABLE IN THE KEPLER MISSION FIELD

International Nuclear Information System (INIS)

Williams, Kurtis A.; De Martino, Domitilla; Silvotti, Roberto; Bruni, Ivan; Dufour, Patrick; Riecken, Thomas S.; Kronberg, Martin; Mukadam, Anjum; Handler, G.

2010-01-01

We announce the identification of a new cataclysmic variable (CV) star in the field of the Kepler Mission, KIC J192410.81+445934.9. This system was identified during a search for compact pulsators in the Kepler field. High-speed photometry reveals coherent large-amplitude variability with a period of 2.94 hr. Rapid, large-amplitude quasi-periodic variations are also detected on time scales of ∼1200 s and ∼650 s. Time-resolved spectroscopy covering one half photometric period shows shallow, broad Balmer and He I absorption lines with bright emission cores as well as strong He II and Bowen blend emission. Radial velocity variations are also observed in the Balmer and He I emission lines that are consistent with the photometric period. We therefore conclude that KIC J192410.81+445934.9 is a nova-like (NL) variable of the UX UMa class in or near the period gap, and it may belong to the rapidly growing subclass of SW Sex systems. Based on Two Micron All Sky Survey photometry and companion star models, we place a lower limit on the distance to the system of ∼500 pc. Due to limitations of our discovery data, additional observations including spectroscopy and polarimetry are needed to confirm the nature of this object. Such data will enable further understanding of the behavior of NL variables in the critical period range of 3-4 hr, where standard CV evolutionary theory finds major problems. The presence of this system in the Kepler Mission field of view also presents a unique opportunity to obtain a continuous photometric data stream of unparalleled length and precision on a CV system.

Machine learning from hard x-ray surveys: applications to magnetic cataclysmic variable studies

Science.gov (United States)

Scaringi, Simone

2009-11-01

Within this thesis are discussed two main topics of contemporary astrophysics. The first is that of machine learning algorithms for astronomy whilst the second is that of magnetic cataclysmic variables (mCVs). To begin, an overview is given of ISINA: INTEGRAL Scouce Identifiction Network Algorithm. This machine learning algorithm, using random forests, is applied to the IBIS/ISGRI data set in order to ease the production of unbiased future soft gamma-ray source catalogues. The feature extraction process on an initial candidate list is described together with feature merging. Three trainng and testing sets are created in order to deal with the diverse time-scales encountered when dealing with the gamma-ray sky: one dealing with faint persistent source recognition, one dealing with strong persistent sources and a final one dealing with transients. For the latter, a new transient detection technique is introduced and described: the transient matrix. Finally the performance of the network is assessed and discussed using the testing set and some illustrative source examples. ISINA is also compared to the more conventional approach of visual inspection. Next mCVs are discussed, and in particular the properties arising from a hard X-ray selected sample which has proven remarkably efficient in detecting intermediate polars and asynchronous polars, two of the rarest type of cataclysmic variables (CVs). This thesis focuses particularly on the link between hard X-ray properties and spin/orbital periods. To this end, a new sample of these objects is constructed by cross-corelating candidate sources detected in INTEGRAL/IBIS observations against catalogues of known CVs. Also included in the analysis are hard X-ray Observations from Swift/BAT and SUZAKU/HXD in order to make the study more complete. It is found that most hard X-ray detected mCVs have Pspin/Porb<0.1 above the period gap. In this respect, attention is given to the very low number of detected systems in any ban

Analysis of cataclysmic variable GSC02197-00886 evolution

Science.gov (United States)

Mitrofanova, A. A.; Borisov, N. V.; Shimansky, V. V.

2014-01-01

We present the spectral analysis of the physical state and evolution of the WZSge-type cataclysmic variable GSC02197-00886. The spectra of the system, covering the total orbital period at the time of the outburst on May 8, 2010, at the late relaxation stage, and in the quiescent state, were obtained at the SAO RAS 6-m BTA telescope in 2010-2012. From the absorption and emission HI, He I, and Fe II lines, we have determined the radial velocities for all the nights of observations and constructed the maps of Doppler tomography for the quiescent state. It was found that during the outburst the spectra of the object were formed in an optically thick accretion disk with an effective temperature of T eff ≈ 45 000 K and in a hotter boundary layer. During the relaxation of the system, the accretion disk gradually became optically thinner in the continuum and in the emission lines. In the quiescent state (July 2012), the continuous spectrum was dominated by the radiation of the cooling white dwarf with T eff = 18 000 K. The emission lines are formed on the surface of the cool star by the X-ray irradiation of the 1RXSJ213807.1+261958 source. We propose a method for determining the parameters of the white dwarf, based on the numerical modeling of the system spectra in the quiescent state and their comparison with the observed spectra. It is shown that the effective temperature of white dwarf has decreased by Δ T eff = 6000 K during the relaxation from August 2010 to July 2012. We have obtained a set of parameters for GSC02197-00886 and shown their good agreement with the average parameters of the W Z Sge-type systems, presented in the literature.

XMM-NEWTON AND OPTICAL OBSERVATIONS OF CATACLYSMIC VARIABLES FROM THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Hilton, Eric J.; Szkody, Paula; Mukadam, Anjum; Henden, Arne; Dillon, William; Schmidt, Gary D.

2009-01-01

We report on XMM-Newton and optical results for six cataclysmic variables that were selected from Sloan Digital Sky Survey (SDSS) spectra because they showed strong He II emission lines, indicative of being candidates for containing white dwarfs with strong magnetic fields. While high X-ray background rates prevented optimum results, we are able to confirm SDSS J233325.92+152222.1 as an intermediate polar from its strong pulse signature at 21 minutes and its obscured hard X-ray spectrum. Ground-based circular polarization and photometric observations were also able to confirm SDSS J142256.31 - 022108.1 as a polar with a period near 4 hr. Photometry of SDSS J083751.00+383012.5 and SDSS J093214.82+495054.7 solidifies the orbital period of the former as 3.18 hr and confirms the latter as a high-inclination system with deep eclipses.

The primary role of the SW Sextantis stars in the evolution of cataclysmic variables

Science.gov (United States)

Torres, Manuel; Gaensicke, Boris; Rodriguez-Gil, Pablo; Long, Knox; Marsh, Tom; Steeghs, Danny; Munoz-Darias, Teodoro; Shahbaz, Tariq; Schmidtobreick, Linda; Schreiber, Matthias

2009-02-01

SW Sextantis stars are a relatively large group of cataclysmic variables (CVs) which plays a fundamental role in our understanding of CV structure and evolution. Very little is known about the properties of their accreting white dwarfs and their donor stars, as the stellar components are usually outshone by an extremely bright accretion flow. Consequently, a proper assesment of their evolutionary state is illusionary. We are monitoring the brightness of a number of SW Sex stars and request here Gemini/GMOS-N ToO time to obtain orbital phase-resolved spectroscopy if one of them enters a low state, since this is the only opportunity for studying the stellar components individually. These data will be used to accurately measure the binary parameters, white dwarf temperature, and distance to the system for a SW Sex star for the first time. The measured stellar masses and radii will especially be a precious input to the theory of compact binary evolution as a whole.

Unravelling the role of the SW Sextantis stars in the evolution of cataclysmic variables

Science.gov (United States)

Torres, Manuel; Steeghs, Danny; Gaensicke, Boris; Marsh, Tom; Rodriguez-Gil, Pablo; Schmidtobreick, Linda; Long, Knox; Schreiber, Matthias

2007-08-01

SW Sextantis stars are a relatively large group of cataclysmic variables (CVs) whose properties contradict all predictions made by the current CV evolution theories. Very little is known about the properties of their accreting white dwarfs and their donor stars, as the stellar components are usually outshone by an extremely bright accretion flow. Consequently, a proper assesment of their evolutionary state is illusionary. We are monitoring the brightness of a number of SW Sex stars and request here Gemini/GMOS-N ToO time to obtain orbital phase-resolved spectroscopy if one of them enters a low state, since this is the only opportunity for studying the stellar components individually. These data will be used to accurately measure the mass ratio of the system which, combined with the orbital inclination derived from modelling of either the disc eclipses in the high state or the ellipsoidal modulation in the low state, will eventually provide the first detailed system parameters for any SW Sex star.

PN G068.1+11.0: A young pre-cataclysmic variable with an extremely hot primary

Science.gov (United States)

Mitrofanova, A. A.; Shimansky, V. V.; Borisov, N. V.; Spiridonova, O. I.; Gabdeev, M. M.

2016-02-01

An analysis of spectroscopic and photometric data for the young pre-cataclysmic variable (PCV) PN G068.1+11.0, which passed through its common-envelope stage relatively recently, is presented. The spectroscopic and photometric data were obtained with the 6-m telescope and Zeiss-1000 telescope of the Special Astrophysical Observatory. The light curves show sinusoidal brightness variations with the orbital-period time scale and brightness-variation amplitudes of Δ m = 1. m41, 1. m62, and 1. m57 in the B, V, and R bands, respectively. The system's spectrum exhibits weak HI (H β-H δ) andHeII λλ4541, 4686, 5411 Å absorption lines during the phases of minimum brightness, as well as HI, HeII, CIII, CIV, NIII, and OII emission lines whose intensity variations are synchronized with variations of the integrated brightness of the system. The emission-line formation in the spectra can be fully explained by the effects of fluorescence of the ultraviolet light from the primary at the surface of the cool star. All the characteristics of the optical light of PN G068.1+11.0 confirm that it is a young PCV containing sdO subdwarf. The radial velocities were measured from a blend of lines of moderately light elements, CIII+NIII λ4640 Å, which is formed at the surface of the secondary due to reflection effects. The ephemeris of the system has been improved through a joint analysis of the radial-velocity curves and light curves of pre-cataclysmic variable, using modelling of the reflection effects. The fundamental parameters of PN G068.1+11.0 have been determined using two evolutionary tracks for planetary-nebula nuclei of different masses (0.7 M ⊙and 0.78 M ⊙). The model spectra for the system and a comparison with the observations demonstrate the possibility of refining the components' effective temperatures if the quality of the spectra used is improved.

CATACLYSMIC VARIABLES FROM THE SLOAN DIGITAL SKY SURVEY. VIII. THE FINAL YEAR (2007–2008)

International Nuclear Information System (INIS)

Szkody, Paula; Anderson, Scott F.; Brooks, Keira; Kronberg, Martin; Riecken, Thomas; Gänsicke, Boris T.; Ross, Nicholas P.; Schmidt, Gary D.; Schneider, Donald P.; Agüeros, Marcel A.; Gomez-Moran, Ada N.; Schwope, Axel D.; Knapp, Gillian R.; Schreiber, Matthias R.

2011-01-01

This paper completes the series of cataclysmic variables (CVs) identified from the Sloan Digital Sky Survey (SDSS) I/II. The coordinates, magnitudes, and spectra of 33 CVs are presented. Among the 33 are eight systems known prior to SDSS (CT Ser, DO Leo, HK Leo, IR Com, V849 Her, V405 Peg, PG1230+226, and HS0943+1404), as well as nine objects recently found through various photometric surveys. Among the systems identified since the SDSS are two polar candidates, two intermediate polar candidates, and one candidate for containing a pulsating white dwarf. Our follow-up data have confirmed a polar candidate from Paper VII and determined tentative periods for three of the newly identified CVs. A complete summary table of the 285 CVs with spectra from SDSS I/II is presented as well as a link to an online table of all known CVs from both photometry and spectroscopy that will continue to be updated as future data appear.

Unravelling the role of SW Sextantis stars in the evolution of cataclysmic variables

Science.gov (United States)

Araujo-Betancor, Sofia; Gansicke, Boris; Long, Knox; Rodriguez-Gil, Pablo

2005-08-01

SW Sextantis stars are a relatively large group of cataclysmic variables whose properties contradict all predictions made by the current CV evolution theories. Very little is known about the properties of their accreting white dwarfs and their donor stars, as the stellar components are usually outshone by an extremely bright accretion flow. Consequently, a proper assessment of their evolutionary state is illusionary. There is one particular behavior of the SW Sex stars that can allow us to overcome this problem: SW Sex stars exhibit low states during which accretion onto the white dwarf decreases or shuts off completely. Only during this rare occasions we can directly observe the white dwarf and the donor star in these systems, and measurements of the white dwarf temperature, spectral type of the donor, mass and distance to the system can be carried out. With this aim in mind, we have set up a long-term monitoring of a group of five SW Sex stars using the 1.3 m telescope at CTIO. Here we propose to activate follow-up TOOs to obtain optical spectra of the low states to accurately determine the fundamental properties of these systems.

VizieR Online Data Catalog: Faint cataclysmic variables from SDSS (Woudt+, 2012)

Science.gov (United States)

Woudt, P. A.; Warner, B.; de Bude, D.; Macfarlane, S.; Schurch, M. P. E.; Zietsman, E.

2013-01-01

We present high-speed photometric observations of 20 faint cataclysmic variables (CVs) selected from the Sloan Digital Sky Survey (SDSS) and Catalina catalogues. Measurements are given of 15 new directly measured orbital periods, including four eclipsing dwarf novae (SDSS 0904+03, CSS 0826-00, CSS 1404-10 and CSS 1626-12), two new polars (CSS 0810+00 and CSS 1503-22) and two dwarf novae with superhumps in quiescence (CSS 0322+02 and CSS 0826-00). Whilst most of the dwarf novae presented here have periods below 2h, SDSS 0805+07 and SSS 0617-36 have relatively long orbital periods of 5.489 and 3.440h, respectively. The double-humped orbital modulations observed in SSS 0221-26, CSS 0345-01, CSS 1300+11 and CSS 1443-17 are typical of low-mass transfer rate dwarf novae. The white dwarf primary of SDSS 0919+08 is confirmed to have non-radial oscillations, and quasi-periodic oscillations were observed in the short-period dwarf nova CSS 1028-08 during outburst. We further report the detection of a new nova-like variable (SDSS 1519+06). The frequency distribution of orbital periods of CVs in the Catalina Real-time Transient Survey (CRTS) has a high peak near ~80min orbital period, independently confirming that found by Gansicke et al. (2009MNRAS.397.2170G) from SDSS sources. We also observe a marked correlation between the median in the orbital period distribution and the outburst class, in the sense that dwarf novae with a single observed outburst (over the 5-year baseline of the CRTS coverage) occur predominantly at shortest orbital period. (2 data files).

NON-THERMAL EMISSION FROM CATACLYSMIC VARIABLES: IMPLICATIONS ON ASTROPARTICLE PHYSICS

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Vojtech Šimon

2013-12-01

Full Text Available We review the lines of evidence that some cataclysmic variables (CVs are the sources of non-thermal radiation. It was really observed in some dwarf novae in outburst, a novalike CV in the high state, an intermediate polar, polars, and classical novae (CNe during outburst. The detection of this radiation suggests the presence of highly energetic particles in these CVs. The conditions for the observability of this emission depend on the state of activity, and the system parameters. We review the processes and conditions that lead to the production of this radiation in various spectral bands, from gamma-rays including TeV emission to radio. Synchrotron and cyclotron emissions suggest the presence of strong magnetic fields in CV. In some CVs, e.g. during some dwarf nova outbursts, the magnetic field generated in the accretion disk leads to the synchrotron jets radiating in radio. The propeller effect or a shock in the case of the magnetized white dwarf (WD can lead to a strong acceleration of the particles that produce gamma-ray emission via pi0 decay; even Cherenkov radiation is possible. In addition, a gamma-ray production via pi0 decay was observed in the ejecta of an outburst of a symbiotic CN. Nuclear reactions during thermonuclear runaway in the outer layer of the WD undergoing CN outburst lead to the production of radioactive isotopes; their decay is the source of gamma-ray emission. The production of accelerated particles in CVs often has episodic character with a very small duty cycle; this makes their detection and establishing the relation of the behavior in various bands difficult.

The effect of nitrogen rate on transgenic corn Cry3Bb1 protein expression.

Science.gov (United States)

Marquardt, Paul T; Krupke, Christian H; Camberato, James J; Johnson, William G

2014-05-01

Combining herbicide-resistant and Bacillus thuringiensis (Bt) traits in corn (Zea mays L.) hybrids may affect insect resistance management owing to volunteer corn. Some Bt toxins may be expressed at lower levels by nitrogen-deficient corn roots. Corn plants with sublethal levels of Bt expression could accelerate the evolution of Bt resistance in target insects. The present objective was to quantify the concentration of Bt (Cry3Bb1) in corn root tissue with varying tissue nitrogen concentrations. Expression of Cry3Bb1 toxin in root tissue was highly variable, but there were no differences in the overall concentration of Cry3Bb1 expressed between roots taken from Cry3Bb1-positive volunteer and hybrid corn plants. The nitrogen rate did affect Cry3Bb1 expression in the greenhouse, less nitrogen resulted in decreased Cry3Bb1 expression, yet this result was not documented in the field. A positive linear relationship of plant nitrogen status on Cry3Bb1 toxin expression was documented. Also, high variability in Cry3Bb1 expression is potentially problematic from an insect resistance management perspective. This variability could create a mosaic of toxin doses in the field, which does not fit into the high-dose refuge strategy and could alter predictions about the speed of evolution of resistance to Cry3Bb1 in western corn rootworm Diabrotica virgifera virgifera LeConte. © 2013 Society of Chemical Industry.

The origin of the infrared light of cataclysmic variable stars

International Nuclear Information System (INIS)

Berriman, G.; Szkody, P.; Capps, R.W.

1985-01-01

This paper presents a model-independent overview of the origin of the near infrared (1-2 μm) light of a sample of 28 cataclysmic binary stars, largely dwarf novae in quiescence. The infrared light comes from the red dwarf that supplies matter to the white dwarf companion and the accretion disc around the white dwarf. The complex nature of the disc prevents near-infrared photometry from being a good probe of the red dwarfs, even in those systems where they are seen in the visual. All that can be found reliably is an upper limit to the proportion light that the red dwarfs supply, and consequently lower limits to the distances to the systems. The infrared light of the discs comes from opaque material and from the optically thin gas that gives rise to the visual and UV emission lines. (author)

PG 1316+678: A young pre-cataclysmic binary with weak reflection effects

Science.gov (United States)

Shimansky, V. V.; Borisov, N. V.; Bikmaev, I. F.; Sakhibullin, N. A.; Shimanskaya, N. N.; Spiridonova, O. I.; Irtuganov, E. N.

2013-03-01

The PG 1316+678 star is classified as a pre-cataclysmic binary, as is evidenced by its photometric and spectroscopic observations. Its orbital period is determined to be P orb = 3.3803d, which coincides with the photometric period. The intensities of the emission HI and HeI lines are shown to vary synchronously with the brightness of the object (Δ m V = 0.065 m , Δ m R = 0.08 m ). These variations arise as the UV radiation from the DAO white dwarf is reflected from the surface of the cold companion. The parameters of the binary are estimated and the time of its evolution after the common-envelope phase is determined to be t ≈ 240 000 years. Thus, PG 1316+678 is a young pre-cataclysmic NN Ser variable with the smallest known photometric reflection effect.

Cataclysmic Variables and Active Binary Stars in Omega Centauri

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Arias, T.; Brochmann, M.; Dorfman, J. L.; White, M. V.; Cool, A. M.

2004-12-01

We report findings from our ongoing research on the globular cluster Omega Centauri (NGC 5139) using a 3x3 mosaic of Wide Field Camera pointings with the HST Advanced Camera for Surveys (ACS). The data consist of F435W (B435), F625W (R625), and F658N (Hα ) images and cover roughly 10x10 arcminutes, out to beyond the cluster's half-mass radius. Our current work is a search for cataclysmic variables (CVs) and active binaries (ABs) (e.g., RS CVn and BY Dra stars) as counterparts to X-ray point sources previously detected with Chandra. The ACS field encompasses 109 of the Chandra sources, 20-50 of which are likely to be cluster members according to our statistical estimates (the rest being primarily active galaxies). Using DAOPHOT to obtain photometry in 20x20 arcsecond patches surrounding each X-ray source, we are constructing color-magnitude diagrams to search for stars with Hα -R625 and/or B435-R625 colors indicative of CVs or ABs in ˜ 1 arcsecond Chandra error circles. With roughly half of the patches analyzed, several AB candidates and only a small number of CV candidates have emerged. Our tentative conclusion is that CVs may be significantly rarer in Omega Cen than in 47 Tuc, in contrast to the comparable numbers ( ˜100) predicted for these two clusters from tidal capture theory (Di Stefano and Rappaport 1994). Alternatively, the CVs could be strongly concentrated toward the cluster center, and thus not yet appear in our sample. To date, most of the patches we have analyzed are 3-4 arcminutes from the cluster center and thus are outside the cluster core (radius 2.6 arcminutes). Our continuing work should soon enable us to resolve this question. This work is supported by NASA grant GO-9442 from the Space Telescope Science Institute.

Non-radial oscillations of rotating stars and their relevance to the short-period oscillations of cataclysmic variables

International Nuclear Information System (INIS)

Papaloizou, J.; Pringle, J.E.

1978-01-01

The usual hypothesis, that the short-period coherent oscillations seen in cataclysmic variables are attributable to g modes in a slowly rotating white dwarf, is considered. It is shown that this hypothesis is untenable for three main reasons: (i) the observed periods are too short for reasonable white dwarf models, (ii) the observed variability of the oscillations is too rapid and (iii) the expected rotation of the white dwarf, due to accretion, invalidates the slow rotation assumption on which standard g-mode theory is based. The low-frequency spectrum of a rotating pulsating star is investigated taking the effects of rotation fully into account. In this case there are two sets of low-frequency modes, the g modes, and modes similar to Rossby waves in the Earth's atmosphere and oceans, which are designated r modes. Typical periods for such modes are 1/m times the rotation period of the white dwarfs outer layers (m is the aximuthal wavenumber). It is concluded that non-radial oscillations of rotating white dwarfs can account for the properties of the oscillations seen in dwarf novae. Application of these results to other systems is also discussed. (author)

EVOLUTION OF CATACLYSMIC VARIABLES AND RELATED BINARIES CONTAINING A WHITE DWARF

International Nuclear Information System (INIS)

Kalomeni, B.; Rappaport, S.; Molnar, M.; Nelson, L.; Quintin, J.; Yakut, K.

2016-01-01

We present a binary evolution study of cataclysmic variables (CVs) and related systems with white dwarf (WD) accretors, including for example, AM CVn systems, classical novae, supersoft X-ray sources (SXSs), and systems with giant donor stars. Our approach intentionally avoids the complications associated with population synthesis algorithms, thereby allowing us to present the first truly comprehensive exploration of all of the subsequent binary evolution pathways that zero-age CVs might follow (assuming fully non-conservative, Roche-lobe overflow onto an accreting WD) using the sophisticated binary stellar evolution code MESA. The grid consists of 56,000 initial models, including 14 WD accretor masses, 43 donor-star masses (0.1–4.7 M ⊙ ), and 100 orbital periods. We explore evolution tracks in the orbital period and donor-mass ( P orb – M don ) plane in terms of evolution dwell times, masses of the WD accretor, accretion rate, and chemical composition of the center and surface of the donor star. We report on the differences among the standard CV tracks, those with giant donor stars, and ultrashort period systems. We show where in parameter space one can expect to find SXSs, present a diagnostic to distinguish among different evolutionary paths to forming AM CVn binaries, quantify how the minimum orbital period in CVs depends on the chemical composition of the donor star, and update the P orb ( M wd ) relation for binaries containing WDs whose progenitors lost their envelopes via stable Roche-lobe overflow. Finally, we indicate where in the P orb – M don the accretion disks will tend to be stable against the thermal-viscous instability, and where gravitational radiation signatures may be found with LISA.

EVOLUTION OF CATACLYSMIC VARIABLES AND RELATED BINARIES CONTAINING A WHITE DWARF

Energy Technology Data Exchange (ETDEWEB)

Kalomeni, B.; Rappaport, S.; Molnar, M. [Department of Physics, and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Nelson, L. [Department of Physics, Bishop’s University, 2600 College St., Sherbrooke, Quebec, QC J1M 1Z7 (Canada); Quintin, J. [Department of Physics, McGill University, Montréal, QC H3A 2T8 (Canada); Yakut, K., E-mail: kalomeni@mit.edu, E-mail: sar@mit.edu, E-mail: momchil.molnar@gmail.com, E-mail: belinda.kalomeni@ege.edu.tr, E-mail: kadri.yakut@ege.edu.tr, E-mail: lnelson@ubishops.ca, E-mail: jquintin@physics.mcgill.ca [Department of Astronomy and Space Sciences, Ege University, 35100, İzmir (Turkey)

2016-12-10

We present a binary evolution study of cataclysmic variables (CVs) and related systems with white dwarf (WD) accretors, including for example, AM CVn systems, classical novae, supersoft X-ray sources (SXSs), and systems with giant donor stars. Our approach intentionally avoids the complications associated with population synthesis algorithms, thereby allowing us to present the first truly comprehensive exploration of all of the subsequent binary evolution pathways that zero-age CVs might follow (assuming fully non-conservative, Roche-lobe overflow onto an accreting WD) using the sophisticated binary stellar evolution code MESA. The grid consists of 56,000 initial models, including 14 WD accretor masses, 43 donor-star masses (0.1–4.7 M {sub ⊙}), and 100 orbital periods. We explore evolution tracks in the orbital period and donor-mass ( P {sub orb}– M {sub don}) plane in terms of evolution dwell times, masses of the WD accretor, accretion rate, and chemical composition of the center and surface of the donor star. We report on the differences among the standard CV tracks, those with giant donor stars, and ultrashort period systems. We show where in parameter space one can expect to find SXSs, present a diagnostic to distinguish among different evolutionary paths to forming AM CVn binaries, quantify how the minimum orbital period in CVs depends on the chemical composition of the donor star, and update the P {sub orb}( M {sub wd}) relation for binaries containing WDs whose progenitors lost their envelopes via stable Roche-lobe overflow. Finally, we indicate where in the P {sub orb}– M {sub don} the accretion disks will tend to be stable against the thermal-viscous instability, and where gravitational radiation signatures may be found with LISA.

Accretion torques due to three-dimensional channelled flows in magnetic cataclysmic variables

International Nuclear Information System (INIS)

Campbell, C.G.

1986-01-01

Angular momentum transfer due to three-dimensional magnetically channelled accretion flows in cataclysmic binaries is considered. The white dwarf experiences a torque due to the twist in that part of its magnetic field which interacts with the accretion stream. The channelling process can also enhance angular momentum exchange between the stream and the orbit by increasing the gravitational torques. The components of the accretion torque are calculated for an arbitrary static magnetic orientation of the white dwarf, and their variation with orientation is presented. For high inclinations of the accreting pole to the orbital plane the component of the accretion torque parallel to this plane can be comparable to its perpendicular component. It is shown that the parallel component of the torque is still significant relative to the perpendicular component if material links to the white dwarf's magnetic field well away from the L 1 region. (author)

Minimum period and the gap in periods of Cataclysmic binaries

International Nuclear Information System (INIS)

Paczynski, B.; Sienkiewicz, R.

1983-01-01

The 81 minute cutoff to the orbital periods of hydrogen-rich cataclysmic binaries is consistent with evolution of those systems being dominated by angular momentum losses due to gravitational radiation. Unfortunately, many uncertainties, mainly poorly known atmospheric opacities below 2000 K, make is physically impossible to verify the quadrupole formula for gravitational radiation by using the observed cutoff at 81 minutes. The upper boundary of the gap in orbital periods observed at about 3 hours is almost certainly due to enhanced angular momentum losses from cataclysmic binaries which have longer periods. The physical mechanism of those losses is not identified, but a possible importance of stellar winds is pointed out. The lower boundary of the gap may be explained with the oldest cataclysmic binaries, whose periods evolved past the minimum at 81 minutes and reached the value of 2 hours within about 12 x 10 9 years after the binary had formed. Those binaries should have secondary components of only 0.02 solar masses, and their periods could be used to estimate ages of the oldest cataclysmic stars, and presumably the age of Galaxy. An alternative explanation for the gap requires that binaries should be detached while crossing the gap. A possible mechanism for this phenomenon is discussed. It requires the secondary components to be about 0.2 solar masses in the binaries just below the gap

A NEW SUB-PERIOD-MINIMUM CATACLYSMIC VARIABLE WITH PARTIAL HYDROGEN DEPLETION AND EVIDENCE OF SPIRAL DISK STRUCTURE

International Nuclear Information System (INIS)

Littlefield, C.; Garnavich, P.; Magno, K.; Applegate, A.; Pogge, R.; Irwin, J.; Marion, G. H.; Kirshner, R.; Vinkó, J.

2013-01-01

We present time-resolved spectroscopy and photometry of CSS 120422:111127+571239 (=SBS 1108+574), a recently discovered SU UMa-type dwarf nova whose 55 minute orbital period is well below the cataclysmic variable (CV) period minimum of ∼78 minutes. In contrast with most other known CVs, its spectrum features He I emission of comparable strength to the Balmer lines, implying a hydrogen abundance less than 0.1 of long-period CVs—but still at least 10 times higher than that in AM CVn stars. Together, the short orbital period and remarkable helium-to-hydrogen ratio suggest that mass transfer in CSS 120422 began near the end of the donor star's main-sequence lifetime, meaning that this CV is a strong candidate progenitor of an AM CVn system as described by Podsiadlowski et al. Moreover, a Doppler tomogram of the Hα line reveals two distinct regions of enhanced emission. While one is the result of the stream-disk impact, the other is probably attributable to spiral disk structure generated when material in the outer disk achieves a 2:1 orbital resonance with respect to the donor.

New cataclysmic variables and other exotic binaries in the globular cluster 47 Tucanae*

Science.gov (United States)

Rivera Sandoval, L. E.; van den Berg, M.; Heinke, C. O.; Cohn, H. N.; Lugger, P. M.; Anderson, J.; Cool, A. M.; Edmonds, P. D.; Wijnands, R.; Ivanova, N.; Grindlay, J. E.

2018-04-01

We present 22 new (+3 confirmed) cataclysmic variables (CVs) in the non-core-collapsed globular cluster 47 Tucanae (47 Tuc). The total number of CVs in the cluster is now 43, the largest sample in any globular cluster so far. For the identifications we used near-ultraviolet (NUV) and optical images from the Hubble Space Telescope, in combination with X-ray results from the Chandra X-ray Observatory. This allowed us to build the deepest NUV CV luminosity function of the cluster to date. We found that the CVs in 47 Tuc are more concentrated towards the cluster centre than the main-sequence turn-off stars. We compared our results to the CV populations of the core-collapsed globular clusters NGC 6397 and NGC 6752. We found that 47 Tuc has fewer bright CVs per unit mass than those two other clusters. That suggests that dynamical interactions in core-collapsed clusters play a major role creating new CVs. In 47 Tuc, the CV population is probably dominated by primordial and old dynamically formed systems. We estimated that the CVs in 47 Tuc have total masses of ˜1.4 M⊙. We also found that the X-ray luminosity function of the CVs in the three clusters is bimodal. Additionally, we discuss a possible double degenerate system and an intriguing/unclassified object. Finally, we present four systems that could be millisecond pulsar companions given their X-ray and NUV/optical colours. For one of them we present very strong evidence for being an ablated companion. The other three could be CO or He white dwarfs.

Comments on the evolution and origin of cataclysmic binaries

International Nuclear Information System (INIS)

Whyte, C.A.; Eggleton, P.P.

1980-01-01

Aspects of the observational data on cataclysmic binaries are discussed and possible correlations between type of behaviour and binary period are noted. A gap between 2 and 3 hr in binary periods is judged to be real. A simple numerical procedure for evolving Roche-lobe-filling stars is described, and applied to white dwarf-red dwarf binaries for various mass loss and angular momentum loss mechanisms, and initial conditions. The results, in which the short-time-scale behaviour of the systems is ignored, are classified into four modes of evolution: normal, nuclear evolution dominated, angular momentum loss dominated and hydrodynamical. The clustering below 2 hr is interpreted in terms of evolution following the hydrodynamical mode, and it is suggested that both stars in such systems are of low mass. This may be the commonest type of cataclysmic binary. A possible explanation for the apparent clustering of classical novae to periods of 3 to 5 hr is given, and evolutionary schemes for cataclysmic binaries outlined. It is suggested that the short-period systems (approximately < 2 hr) arise mainly from late case B mass transfer in the original binary and the longer period systems mainly from case C. (author)

Broad-Band Variability in Accreting Compact Objects

Directory of Open Access Journals (Sweden)

S. Scaringi

2015-02-01

Full Text Available Cataclysmic variable stars are in many ways similar to X-ray binaries. Both types of systems possess an accretion disk, which in most cases can reach the surface (or event horizon of the central compact object. The main difference is that the embedded gravitational potential well in X-ray binaries is much deeper than those found in cataclysmic variables. As a result, X-ray binaries emit most of their radiation at X-ray wavelengths, as opposed to cataclysmic variables which emit mostly at optical/ultraviolet wavelengths. Both types of systems display aperiodic broad-band variability which can be associated to the accretion disk. Here, the properties of the observed X-ray variability in XRBs are compared to those observed at optical wavelengths in CVs. In most cases the variability properties of both types of systems are qualitatively similar once the relevant timescales associated with the inner accretion disk regions have been taken into account. The similarities include the observed power spectral density shapes, the rms-flux relation as well as Fourier-dependant time lags. Here a brief overview on these similarities is given, placing them in the context of the fluctuating accretion disk model which seeks to reproduce the observed variability.

Radioimmunoassay of creatine kinase BB isoenzyme

International Nuclear Information System (INIS)

Geng Jianguo

1988-01-01

A radioimmunoassay of creatine kinase BB isoenzyme (CK-BB) was developed by using CK-BB purified from human brain. The CK-BB antiserum was raised by immunizing rabbite and 125 I-CK-BB iodinated with Bolton-Hunter reagent. The affinity constant was 3.0 x 10 9 mol/L. No cross reactions with creatine kinase MM isoenzyme and neuron-specific enolase were found. The measuring range was 3.5 x 10 -8 ∼ 1.2 x 10 -5 mmol/L, the average recovery rate 97.5%, with the inter and intrassay CV 3.1% and 12%, respectively. The average serum CK-BB concentration in 83 normal persons was 1.5 x 10 -7 +- 8.1 x 10 -8 mmol/L, quite different from the values of acute myocardial infarction (5.2 x 10 -6 +- 1.2 x 10 -4 mmol/L, n = 28) and cerebral vascular accident (8.4 x 10 -4 +- 5.0 x 10 -4 mmol/L, n = 10)

Selective method for identification and quantification of Bifidobacterium animalis subspecies lactis BB-12 (BB-12) from the gastrointestinal tract of healthy volunteers ingesting a combination probiotic of BB-12 and Lactobacillus rhamnosus GG.

Science.gov (United States)

Poutsiaka, D D; Mahoney, I J; McDermott, L A; Stern, L L; Thorpe, C M; Kane, A V; Baez-Giangreco, C; McKinney, J; Davidson, L E; Leyva, R; Goldin, B; Snydman, D R

2017-05-01

To develop a novel validated method for the isolation of Bifidobacterium animalis ssp. lactis BB-12 (BB-12) from faecal specimens and apply it to studies of BB-12 and Lactobacillus rhamnosus GG (LGG) recovered from the healthy human gastrointestinal (GI) tract. A novel method for isolating and enumerating BB-12 was developed based on its morphologic features of growth on tetracycline-containing agar. The method identified BB-12 correctly from spiked stool close to 100% of the time as validated by PCR confirmation of identity, and resulted in 97-104% recovery of BB-12. The method was then applied in a study of the recovery of BB-12 and LGG from the GI tract of healthy humans consuming ProNutrients ® Probiotic powder sachet containing BB-12 and LGG. Viable BB-12 and LGG were recovered from stool after 21 days of probiotic ingestion compared to baseline. In contrast, no organisms were recovered 21 days after baseline in the nonsupplemented control group. We demonstrated recovery of viable BB-12, using a validated novel method specific for the isolation of BB-12, and LGG from the GI tract of healthy humans who consumed the probiotic supplement. This method will enable more detailed and specific studies of BB-12 in probiotic supplements, including when in combination with LGG. © 2017 The Society for Applied Microbiology.

Radioimmunoassay of creatine kinase BB isoenzyme

Energy Technology Data Exchange (ETDEWEB)

Jianguo, Geng [Shanghai Medical Univ. (China). Zhongshan Hospital; and others

1988-11-01

A radioimmunoassay of creatine kinase BB isoenzyme (CK-BB) was developed by using CK-BB purified from human brain. The CK-BB antiserum was raised by immunizing rabbite and {sup 125}I-CK-BB iodinated with Bolton-Hunter reagent. The affinity constant was 3.0 x 10{sup 9} mol/L. No cross reactions with creatine kinase MM isoenzyme and neuron-specific enolase were found. The measuring range was 3.5 x 10{sup -8} {approx} 1.2 x 10{sup -5} mmol/L, the average recovery rate 97.5%, with the inter and intrassay CV 3.1% and 12%, respectively. The average serum CK-BB concentration in 83 normal persons was 1.5 x 10{sup -7} +- 8.1 x 10{sup -8} mmol/L, quite different from the values of acute myocardial infarction (5.2 x 10{sup -6} +- 1.2 x 10{sup -4} mmol/L, n = 28) and cerebral vascular accident (8.4 x 10{sup -4} +- 5.0 x 10{sup -4} mmol/L, n = 10).

The autophagy-related genes BbATG1 and BbATG8 have different functions in differentiation, stress resistance and virulence of mycopathogen Beauveria bassiana

Science.gov (United States)

Ying, Sheng-Hua; Liu, Jing; Chu, Xin-Ling; Xie, Xue-Qin; Feng, Ming-Guang

2016-01-01

Autophagy-related proteins play significantly different roles in eukaryotes. In the entomopathogenic fungus Beauveria bassiana, autophagy is associated with fungal growth and development. BbATG1 (a serine/threonine protein kinase) and BbATG8 (a ubiquitin-like protein) have similar roles in autophagy, but different roles in other processes. Disruption mutants of BbATG1 and BbATG8 had impaired conidial germination under starvation stress. The mutant ΔBbATG8 exhibited enhanced sensitivity to oxidative stress, while a ΔBbATG1 mutant did not. BbATG1 and BbATG8 showed different roles in spore differentiation. The blastospore yield was reduced by 70% and 92% in ΔBbATG1 and ΔBbATG8 mutants, respectively, and the double mutant had a reduction of 95%. Conidial yield was reduced by approximately 90% and 50% in ΔBbATG1 and ΔBbATG8 mutants, respectively. A double mutant had a reduction similar to ΔBbATG1. Additionally, both BbATG1 and BbATG8 affected the levels of conidial protein BbCP15p required for conidiation. The virulence of each autophagy-deficient mutant was considerably weakened as indicated in topical and intrahemocoel injection assays, and showed a greater reduction in topical infection. However, BbATG1 and BbATG8 had different effects on fungal virulence. Our data indicate that these autophagy-related proteins have different functions in fungal stress response, asexual development and virulence. PMID:27197558

Mind the Gap when Data Mining the Ritter-Kolb Cataclysmic Variable Catalogue

Science.gov (United States)

Sparks, Warren M.; Sion, Edward M.

2017-01-01

The cataclysmic variable (CV) binary consists of a white dwarf primary and a low-mass secondary which overflows its Roche lobe. The Ritter-Kolb catalogue (2003, A&A, 404, 301) is a collection (~1000) of CV binaries and related objects. We have mined this catalogue for CVs with unevolved secondaries whose mass ratio (secondary/primary) is known (~130). A plot of the secondary mass verses the log of the orbital period exhibits the well-known period gap at 2-3 hrs. In addition, this plot shows that the secondary masses just above the period gap are collectively much larger than those just below. The average of the first ten secondary masses above the period is 180% larger than the average below the gap.The disrupted magnetic braking hypothesis (Howell, Nelson, and Rappaport 2001, ApJ, 550, 897 [HNR]) predicts that when the secondary becomes fully convective, the magnetic braking, which has driven the secondary out of thermal equilibrium, stops. In adjusting to thermal equilibrium the secondary shrinks below its Roche lobe and no longer loses mass. The binary system ceases to appear as a CV until gravitational radiation loss brings the secondary back in contact with its Roche lobe. This scenario is at odds with the apparent secondary mass loss across the period gap. Either the secondary continues to lose mass while crossing the period gap or the secondary masses are miscalculated!Magnetic braking causes the secondary to expand or inflate larger than its single star counterpart. Any orbital parameter calculation which assumes a radius-mass relationship based on single main-sequence stars will overestimate the mass of the secondary. We can approximate this mass overestimation from calculations by HNR which take into account the thermal heating from magnetic braking. Using this approximation as a first-order correction to the secondary mass, we replot the deflated secondary mass versus the binary period. The deflated masses immediately above and below the period gap are

VizieR Online Data Catalog: Radial velocities of 35 cataclysmic variables (Thorstensen+, 2016)

Science.gov (United States)

Thorstensen, J. R.; Alper, E. H.; Weil, K. E.

2017-02-01

We present spectroscopic follow-up observations of 35 newly discovered cataclysmic variables (CVs), 32 of which were found by the Catalina Real Time Transient Surveys (CRTS; Drake et al. 2009, Cat. J/ApJ/696/870; Drake et al. 2014, Cat. J/MNRAS/441/1186; Breedt et al. 2014, Cat. J/MNRAS/443/3174), ASAS-SN (Shappee et al. 2014ApJ...788...48S), and/or MASTER (Lipunov et al. 2010AdAst2010E..30L). All our observations are from Michigan-Dartmouth-MIT (MDM) Observatory on Kitt Peak, Arizona. For nearly all the spectra, we used the "modspec" spectrograph (a description of the modspec can be found at http://mdm.kpno.noao.edu/Manuals/ModSpec/modspec_man.html) with a 600line/mm grating. We mostly used a SITe 20482 CCD detector, which yielded 2Å/pixel from 4210 to 7500Å, with declining throughput toward the ends of the spectral range. When this detector was unavailable, we used a very similar 10242 SITe detector ("Templeton"), which covered 4660 to 6730Å. The modspec was mounted mostly on the 2.4m Hiltner telescope, but for some of the brighter objects, we used the 1.3m McGraw-Hill telescope. For a few of the 1.3m spectra, we used the Mark III grism spectrograph, which covered 4580 to 6850Å at 2.3Å/pixel. On both telescopes and with both spectrographs, we used an Andor Ikon camera to view the reflective slit jaws through a microscope and guided the telescope with a separate off-axis guider. With this arrangement we could place any object that was bright enough for a usable spectrum in the slit and track it accurately even if the portion of the light spilling onto the slit jaws was invisible. Our emission-line radial velocities are almost entirely of Hα, since it almost always gives the best signal-to-noise ratio with our instrument. (3 data files).

Hydrodynamic ejection of bipolar flows from objects undergoing disk accretion: T Tauri stars, massive pre-main-sequence objects, and cataclysmic variables

International Nuclear Information System (INIS)

Torbett, M.V.

1984-01-01

A general mechanism is presented for generating pressure-driven winds that are intrinsically bipolar from objects undergoing disk accretion. The energy librated in a boundary layer shock as the disk matter impacts the central object is shown to be sufficient to eject a fraction βapprox.10 -2 to 10 -3 of the accreted mass. These winds are driven by a mechanism that accelerates the flow perpendicular to the plane of the disk and can therefore account for the bipolar geometry of the mass loss observed near young stars. The mass loss contained in these winds is comparable to that inferred for young stars. Thus, disk accretion-driven winds may constitute the T Tauri phase of stellar evolution. This mechanism is generally applicable, and thus massive pre-main-sequence objects as well as cataclysmic variables at times of enhanced accretion are predicted to eject bipolar outflows as well. Unmagnetized accreting neutron stas are also expected to eject bipolar flows. Since this mechanism requires stellar surfaces, however, it will not operate in disk accretion onto black holes

Diagnostic value of serum creatine kinase-BB for acute meningitis in adults

Directory of Open Access Journals (Sweden)

Seyed Mohammad Alavi

2017-01-01

Full Text Available Objective: To find out an easy and feasible test instead of cerebrospinal fluid analysis for the diagnosis of acute meningitis. Methods: This cross-sectional study was conducted in 2013 in Ahvaz, a city located in the Southwest Iran including 75 patients with clinical diagnosis of fever, headache, vomiting and neck stiffness suspected to have acute meningitis based on cerebrospinal fluid analysis. In the beginning, the patients were divided into two categories as acute meningitis, and non-acute meningitis. Then, 5 L of blood was taken from each patient to determine serum creatine kinase isoenzyme-BB by using ELISA method. After that, the related data including demographics, clinical and laboratory results were analyzed by SPSS software version 16 using Chi-square test for qualitative variables and student’s t-test for quantitative variables. Results: Among the total 75 patients, 37 (49.3% were males and 38 (50.7% were females including 45 patients (60% with acute meningitis and 30 patients (40% without acute meningitis. On the other hand, CK-BB serum levels in acute meningitis and non-acute meningitis patients were 18.23 ± 7.56 and 2.67 ± 1.62, respectively, so significant difference was found between acute meningitis group and non-acute meningitis group (P < 0.000 1. Conclusions: Serum creatine kinase isoenzyme-BB test is a useful test to differentiate acute meningitis from non-acute meningitis among suspected cases of meningitis disease, so measuring the CK-BB serum level in Iran's health system with an expanded health setting especially in remote areas will be useful and helpful in prompt diagnosis and treatment of the acute meningitis.

Bb4l event generator, interferences and off-shell effects

CERN Document Server

Peyruchat, Leo Paul

2017-01-01

Proton-proton collisions happening in LHC create lots of data. To understand the underlying physics behind these events, the real data must be compared to simulated events. A new generator,called the bb4l model, is able to simulate collisions happening in LHC with new interesting features regarding process creating two W bosons and two b quarks. One of them is that it takes interferences between different processes into account. Such effects have always been neglected in the case of top pair or single top production, but with the increasing sensitivity of the detectors it is becoming important to know precisely their amplitude. The goal of this study is to separate events generated with bb4l into different categories, and then to look at many variables and look for differences between categories.

Specificity of EIA immunoassay for complement factor Bb testing.

Science.gov (United States)

Pavlov, Igor Y; De Forest, Nikol; Delgado, Julio C

2011-01-01

During the alternative complement pathway activation, factor B is cleaved in two fragments, Ba and Bb. Concentration of those fragments is about 2 logs lower than of factor B present in the blood, which makes fragment detection challenging because of potential cross-reactivity. Lack of information on Bb assay cross-reactivity stimulated the authors to investigate this issue. We ran 109 healthy donor EDTA plasmas and 80 sera samples with both factor B immunodiffusion (The Binding Site) and Quidel Bb EIA assays. During the study it was shown that physiological concentrations of gently purified factor B demonstrated approximately 0.15% cross-reactivity in the Quidel Bb EIA assay. We also observed that Bb concentration in serum is higher than in plasma due to complement activation during clot formation which let us use sera as samples representing complement activated state. Our study demonstrated that despite the potential 0.15% cross-reactivity between endogenous factor B and cleaved Bb molecule, measuring plasma concentrations of factor Bb is adequate to evaluate the activation of the alternative complement pathway.

Radio emission from the nova-like variable AC Cancri and the symbiotic variable AG Draconis

International Nuclear Information System (INIS)

Torbett, M.V.; Campbell, B.; Mount Wilson and Las Campanas Observatories, Pasadena, CA)

1987-01-01

Radio emission at 6 cm has been detected from the nova-like cataclysmic variable AC Cnc and the symbiotic variable AG Dra. The AC Cnc observation constitutes the first radio detection in this class of objects. The AG Dra source is probably resolved and appears to show asymmetric, extended structure. The radio emission can best be explained by thermal bremsstrahlung. 26 references

Research of Precataclysmic Variables with Radius Excesses

Science.gov (United States)

Deminova, N. R.; Shimansky, V. V.; Borisov, N. V.; Gabdeev, M. M.; Shimanskaya, N. N.

2017-06-01

The results of spectroscopic observations of the pre-cataclysmic variable NSVS 14256825, which is a HW Vir binary system, were analyzed. The chemical composition is determined, the radial velocities and equivalent widths of a given star are measured. The fundamental parameters of the components were determined (R1 = 0.166 R⊙ , M2 = 0.100 M⊙ , R2 = 0.122 R⊙). It is shown that the secondary component has a mass close to the mass of brown dwarfs. A comparison of two close binary systems is made: HS 2333 + 3927 and NSVS 14256825. A radius-to-mass relationship for the secondary components of the studied pre-cataclysmic variables is constructed. It is concluded that an excess of radii relative to model predictions for MS stars is observed in virtually all systems.

Krakatoa Erupts!: Using a Historic Cataclysm to Teach Modern Science

Science.gov (United States)

Clary, Renee; Wandersee, James

2011-01-01

Through integration of geology, biology, chemistry, and the history of science, the historic Krakatoa eruption offers a unique portal for student inquiry in the classroom. Students are inherently fascinated by natural disasters, and modern comparisons to the Krakatoa cataclysm are as close as the day's news. This article uses the historic Krakatoa…

EST Table: BB991540 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available BB991540 E_ET_MSV3_15F09_R_0 10/09/28 37 %/160 aa ref|NP_001129360.1| osiris 9 [Bom...byx mori] gb|ACI23620.1| osiris 9 [Bombyx mori] 10/08/28 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h BB992168 MSV3 ...

Security of BB84 with weak randomness and imperfect qubit encoding

Science.gov (United States)

Zhao, Liang-Yuan; Yin, Zhen-Qiang; Li, Hong-Wei; Chen, Wei; Fang, Xi; Han, Zheng-Fu; Huang, Wei

2018-03-01

The main threats for the well-known Bennett-Brassard 1984 (BB84) practical quantum key distribution (QKD) systems are that its encoding is inaccurate and measurement device may be vulnerable to particular attacks. Thus, a general physical model or security proof to tackle these loopholes simultaneously and quantitatively is highly desired. Here we give a framework on the security of BB84 when imperfect qubit encoding and vulnerability of measurement device are both considered. In our analysis, the potential attacks to measurement device are generalized by the recently proposed weak randomness model which assumes the input random numbers are partially biased depending on a hidden variable planted by an eavesdropper. And the inevitable encoding inaccuracy is also introduced here. From a fundamental view, our work reveals the potential information leakage due to encoding inaccuracy and weak randomness input. For applications, our result can be viewed as a useful tool to quantitatively evaluate the security of a practical QKD system.

Rotavirus shedding following administration of RV3-BB human neonatal rotavirus vaccine.

Science.gov (United States)

Cowley, Daniel; Boniface, Karen; Bogdanovic-Sakran, Nada; Kirkwood, Carl D; Bines, Julie E

2017-08-03

The RV3-BB human neonatal rotavirus vaccine aims to provide protection from severe rotavirus disease from birth. A phase IIa safety and immunogenicity trial was undertaken in Dunedin, New Zealand between January 2012 and April 2014. Healthy, full-term (≥ 36 weeks gestation) babies, who were 0-5 d old were randomly assigned (1:1:1) to receive 3 doses of oral RV3-BB vaccine with the first dose given at 0-5 d after birth (neonatal schedule), or the first dose given at about 8 weeks after birth (infant schedule), or to receive placebo (placebo schedule). Vaccine take (serum immune response or stool shedding of vaccine virus after any dose) was detected after 3 doses of RV3-BB vaccine in >90% of participants when the first dose was administered in the neonatal and infant schedules. The aim of the current study was to characterize RV3-BB shedding and virus replication following administration of RV3-BB in a neonatal and infant vaccination schedule. Shedding was defined as detection of rotavirus by VP6 reverse transcription polymerase chain reaction (RT-PCR) in stool on days 3-7 after administration of RV3-BB. Shedding of rotavirus was highest following vaccination at 8 weeks of age in both neonatal and infant schedules (19/30 and 17/27, respectively). Rotavirus was detected in stool on days 3-7, after at least one dose of RV3-BB, in 70% (21/30) of neonate, 78% (21/27) of infant and 3% (1/32) placebo participants. In participants who shed RV3-BB, rotavirus was detectable in stool on day 1 following RV3-BB administration and remained positive until day 4-5 after administration. The distinct pattern of RV3-BB stool viral load demonstrated using a NSP3 quantitative qRT-PCR in participants who shed RV3-BB, suggests that detection of RV3-BB at day 3-7 was the result of replication rather than passage through the gastrointestinal tract.

On the history of the early meteoritic bombardment of the Moon: Was there a terminal lunar cataclysm?

Science.gov (United States)

Michael, Greg; Basilevsky, Alexander; Neukum, Gerhard

2018-03-01

This work revisits the hypothesis of the so-called 'lunar terminal cataclysm' suggested by Tera et al. (1973, 1974) as a strong peak in the meteorite bombardment of the Moon around 3.9 Ga ago. According to the hypothesis, most of the impact craters observed on the lunar highlands formed during this short time period and thus formed the majority of the lunar highland impact breccias and melts. The hypothesis arose from the observation that the ages of highland samples from all the lunar missions are mostly grouped around 3.9-4.0 Ga. Since those missions, however, radiometric dating techniques have progressed and many samples, both old and new, have been re-analyzed. Nevertheless, the debate over whether there was a terminal cataclysm persists. To progress in this problem we summarized results of 269 K-Ar datings (mostly made using the 40Ar-39Ar technique) of highland rocks represented by the Apollo 14, 15, 16, 17 and Luna 20 samples and 94 datings of clasts of the highland rocks from 23 lunar meteorites representing 21 localities on the lunar surface, and considered them jointly with the results of our modelling of the cumulative effect of the impact gardening process on the presence of impact melt of different ages at the near-surface of the Moon. The considered results of K-Ar dating of the Apollo-Luna samples of lunar highland rocks confirmed a presence of strong peak centered at 3.87 Ga. But since the time when the hypothesis of terminal cataclysm was suggested, it has become clear that this peak could be a result of sampling bias: it is the only prominent feature at the sites with an apparent domination of Imbrium basin ejecta (Apollo 14 and 15) and the age pattern is more complicated for the sites influenced not only by Imbrium ejecta but also that of other basins (Nectaris at the Apollo 16 site and Serenitatis at the Apollo 17 site). Our modelling shows that the cataclysm, if it occurred, should produce a strong peak in the measured age values but we see in

The Evolution of Cataclysmic Variables as Revealed by Their Donor Stars

Science.gov (United States)

Knigge, Christian; Baraffe, Isabelle; Patterson, Joseph

2011-06-01

We present an attempt to reconstruct the complete evolutionary path followed by cataclysmic variables (CVs), based on the observed mass-radius relationship of their donor stars. Along the way, we update the semi-empirical CV donor sequence presented previously by one of us, present a comprehensive review of the connection between CV evolution and the secondary stars in these systems, and reexamine most of the commonly used magnetic braking (MB) recipes, finding that even conceptually similar ones can differ greatly in both magnitude and functional form. The great advantage of using donor radii to infer mass-transfer and angular-momentum-loss (AML) rates is that they sample the longest accessible timescales and are most likely to represent the true secular (evolutionary average) rates. We show explicitly that if CVs exhibit long-term mass-transfer-rate fluctuations, as is often assumed, the expected variability timescales are so long that other tracers of the mass-transfer rate—including white dwarf (WD) temperatures—become unreliable. We carefully explore how much of the radius difference between CV donors and models of isolated main-sequence stars may be due to mechanisms other than mass loss. The tidal and rotational deformation of Roche-lobe-filling stars produces ~= 4.5% radius inflation below the period gap and ~= 7.9% above. A comparison of stellar models to mass-radius data for non-interacting stars suggests a real offset of ~= 1.5% for fully convective stars (i.e., donors below the gap) and ~= 4.9% for partially radiative ones (donors above the gap). We also show that donor bloating due to irradiation is probably smaller than, and at most comparable to, these effects. After calibrating our models to account for these issues, we fit self-consistent evolution sequences to our compilation of donor masses and radii. In the standard model of CV evolution, AMLs below the period gap are assumed to be driven solely by gravitational radiation (GR), while AMLs

THE EVOLUTION OF CATACLYSMIC VARIABLES AS REVEALED BY THEIR DONOR STARS

International Nuclear Information System (INIS)

Knigge, Christian; Baraffe, Isabelle; Patterson, Joseph

2011-01-01

We present an attempt to reconstruct the complete evolutionary path followed by cataclysmic variables (CVs), based on the observed mass-radius relationship of their donor stars. Along the way, we update the semi-empirical CV donor sequence presented previously by one of us, present a comprehensive review of the connection between CV evolution and the secondary stars in these systems, and reexamine most of the commonly used magnetic braking (MB) recipes, finding that even conceptually similar ones can differ greatly in both magnitude and functional form. The great advantage of using donor radii to infer mass-transfer and angular-momentum-loss (AML) rates is that they sample the longest accessible timescales and are most likely to represent the true secular (evolutionary average) rates. We show explicitly that if CVs exhibit long-term mass-transfer-rate fluctuations, as is often assumed, the expected variability timescales are so long that other tracers of the mass-transfer rate-including white dwarf (WD) temperatures-become unreliable. We carefully explore how much of the radius difference between CV donors and models of isolated main-sequence stars may be due to mechanisms other than mass loss. The tidal and rotational deformation of Roche-lobe-filling stars produces ≅ 4.5% radius inflation below the period gap and ≅ 7.9% above. A comparison of stellar models to mass-radius data for non-interacting stars suggests a real offset of ≅ 1.5% for fully convective stars (i.e., donors below the gap) and ≅ 4.9% for partially radiative ones (donors above the gap). We also show that donor bloating due to irradiation is probably smaller than, and at most comparable to, these effects. After calibrating our models to account for these issues, we fit self-consistent evolution sequences to our compilation of donor masses and radii. In the standard model of CV evolution, AMLs below the period gap are assumed to be driven solely by gravitational radiation (GR), while AMLs

InterProScan Result: BB993418 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available BB993418 BB993418_6_ORF2 7325F21342D1E3DD PANTHER PTHR12479:SF4 LYSOSOMAL-ASSOCIATED TRANSME...MBRANE PROTEIN 1.9e-69 T IPR018400 Lysosomal-associated transmembrane protein, CG14767-PB ...

Los destructivos B&B

Directory of Open Access Journals (Sweden)

Daniel López

2015-01-01

Full Text Available En los últimos años varios dibujos animados para jóvenes han cautivado a los mayores por la temática que tratan. Ese es el caso de los Simpson o de Vida de Perros, que son fiel representación de la sociedad norteamericana. Ahora se suma a este fenómeno el dúo juvenil integrado por los destructivos BEAVIS & BUTT HEAD -B&B- jóvenes desempleados piromaniáticos cuyas vidas están marcadas por sus locuras, el amor a la música heavy metal, viven en una zona suburbana y retratan fielmente a la sociedad estadounidense. La exhibición de esta serie en América Latina es tomada como otra forma de penetración cultural norteamericana, son productos de mala calidad que nada tienen que ver con nuestra manera de ser, pero el marketing se impone y muy posiblemente en poco tiempo los B&B se impondrá como los Simpson.

A precise measurement of ΓZ-->bb/ΓZ-->hadrons

Science.gov (United States)

Buskulic, D.; de Bonis, I.; Decamp, D.; Ghez, P.; Goy, C.; Lees, J.-P.; Minard, M.-N.; Pietrzyk, B.; Ariztizabal, F.; Comas, P.; Crespo, J. M.; Delfino, M.; Efthymiopoulos, I.; Fernandez, E.; Fernandez-Bosman, M.; Gaitan, V.; Garrido, Ll.; Mattison, T.; Pacheco, A.; Padilla, C.; Pascual, A.; Creanza, D.; de Palma, M.; Farilla, A.; Iaselli, G.; Maggi, G.; Natali, S.; Nuzzo, S.; Quattromini, M.; Ranieri, A.; Raso, G.; Romano, F.; Ruggieri, F.; Selvaggi, G.; Silvestris, L.; Tempesta, P.; Zito, G.; Chai, Y.; Hu, H.; Huang, D.; Huang, X.; Lin, J.; Wang, T.; Xie, Y.; Xu, D.; Xu, R.; Zhang, J.; Zhang, L.; Zhao, W.; Blucher, E.; Bonvicini, G.; Boudreau, J.; Casper, D.; Drevermann, H.; Forty, R. W.; Ganis, G.; Gay, C.; Hagelberg, R.; Harvey, J.; Hilgart, J.; Jacobsen, R.; Jost, B.; Knobloch, J.; Lehraus, I.; Lohse, T.; Maggi, M.; Markou, C.; Martinez, M.; Mato, P.; Meinhard, H.; Minten, A.; Miotto, A.; Miquel, R.; Moser, H.-G.; Palazzi, P.; Pater, J. R.; Perlas, J. A.; Pusztaszeri, J.-F.; Ranjard, F.; Redlinger, G.; Rolandi, L.; Rothberg, J.; Ruan, T.; Saich, M.; Schlatter, D.; Schmelling, M.; Sefkow, F.; Tejessy, W.; Tomalin, I. R.; Veenhof, R.; Wachsmuth, H.; Wasserbaech, S.; Wiedenmann, W.; Wildish, T.; Witzeling, W.; Wotschack, J.; Ajaltouni, Z.; Badaud, F.; Bardadin-Otwinowska, M.; El Fellous, R.; Falvard, A.; Gay, P.; Guicheney, C.; Henrard, P.; Jousset, J.; Michel, B.; Montret, J.-C.; Pallin, D.; Perret, P.; Podlyski, F.; Proriol, J.; Prulhière, F.; Saadi, F.; Fearnley, T.; Hansen, J. B.; Hansen, J. D.; Hansen, J. R.; Hansen, P. H.; Møllerud, R.; Nilsson, B. S.; Kyriakis, A.; Simopoulou, E.; Siotis, I.; Vayaki, A.; Zachariadou, K.; Badier, J.; Blondel, A.; Bonneaud, G.; Brient, J. C.; Fouque, G.; Orteu, S.; Rougé, A.; Rumpf, M.; Tanaka, R.; Verderi, M.; Videau, H.; Candlin, D. J.; Parsons, M. I.; Veitch, E.; Focardi, E.; Moneta, L.; Parrini, G.; Corden, M.; Georgiopoulos, C.; Ikeda, M.; Levinthal, D.; Antonelli, A.; Baldini, R.; Bencivenni, G.; Bologna, G.; Bossi, F.; Campana, P.; Capon, G.; Cerutti, F.; Chiarella, V.; D'Ettorre-Piazzoli, B.; Felici, G.; Laurelli, P.; Mannocchi, G.; Murtas, F.; Murtas, G. P.; Passalacqua, L.; Pepe-Altarelli, M.; Picchi, P.; Colrain, P.; Ten Have, I.; Lynch, J. G.; Maitland, W.; Morton, W. T.; Raine, C.; Reeves, P.; Scarr, J. M.; Smith, K.; Smith, M. G.; Thompson, A. S.; Turnbull, R. M.; Brandl, B.; Braun, O.; Geweniger, C.; Hanke, P.; Hepp, V.; Kluge, E. E.; Maumary, Y.; Putzer, A.; Rensch, B.; Stahl, A.; Tittel, K.; Wunsch, M.; Beuselinck, R.; Binnie, D. M.; Cameron, W.; Cattaneo, M.; Colling, D. J.; Dornan, P. J.; Greene, A. M.; Hassard, J. F.; Lieske, N. M.; Moutoussi, A.; Nash, J.; Patton, S.; Payne, D. G.; Phillips, M. J.; San Martin, G.; Sedgbeer, J. K.; Wright, A. G.; Girtler, P.; Kuhn, D.; Rudolph, G.; Vogl, R.; Bowdery, C. K.; Brodbeck, T. J.; Finch, A. J.; Foster, F.; Hughes, G.; Jackson, D.; Keemer, N. R.; Nuttall, M.; Patel, A.; Sloan, T.; Snow, S. W.; Whelan, E. P.; Kleinknecht, K.; Raab, J.; Renk, B.; Sander, H.-G.; Schmidt, H.; Steeg, F.; Walther, S. M.; Wanke, R.; Wolf, B.; Bencheikh, A. M.; Benchouk, C.; Bonissent, A.; Carr, J.; Coyle, P.; Drinkard, J.; Etienne, F.; Nicod, D.; Papalexiou, S.; Payre, P.; Roos, L.; Rousseau, D.; Schwemling, P.; Talby, M.; Adlung, S.; Assmann, R.; Bauer, C.; Blum, W.; Brown, D.; Cattaneo, P.; Dehning, B.; Dietl, H.; Dydak, F.; Frank, M.; Halley, A. W.; Jakobs, K.; Lauber, J.; Lütjens, G.; Lutz, G.; Männer, W.; Richter, R.; Schröder, J.; Schwarz, A. S.; Settles, R.; Seywerd, H.; Stierlin, U.; Stiegler, U.; St. Denis, R.; Wolf, G.; Alemany, R.; Boucrot, J.; Callot, O.; Cordier, A.; Davier, M.; Duflot, L.; Grivaz, J.-F.; Heusse, Ph.; Jaffe, D. E.; Janot, P.; Kim, D. W.; Le Diberder, F.; Lefrançois, J.; Lutz, A.-M.; Schune, M.-H.; Veillet, J.-J.; Videau, I.; Zhang, Z.; Abbaneo, D.; Bagliesi, G.; Batignani, G.; Bottigli, U.; Bozzi, C.; Calderini, G.; Carpinelli, M.; Ciocci, M. A.; dell'Orso, R.; Ferrante, I.; Fidecaro, F.; Foà, L.; Forti, F.; Giassi, A.; Giorgi, M. A.; Gregorio, A.; Ligabue, F.; Lusiani, A.; Mannelli, E. B.; Marrocchesi, P. S.; Messineo, A.; Palla, F.; Rizzo, G.; Sanguinetti, G.; Spagnolo, P.; Steinberger, J.; Tenchini, R.; Tonelli, G.; Triggiani, G.; Vannini, C.; Venturi, A.; Verdini, P. G.; Walsh, J.; Betteridge, A. P.; Gao, Y.; Green, M. G.; March, P. V.; Mir, Ll. M.; Medcalf, T.; Quazi, I. S.; Strong, J. A.; West, L. R.; Botterill, D. R.; Clifft, R. W.; Edgecock, T. R.; Haywood, S.; Norton, P. R.; Thompson, J. C.; Bloch-Devaux, B.; Colas, P.; Duarte, H.; Emery, S.; Kozanecki, W.; Lançon, E.; Lemaire, M. C.; Locci, E.; Marx, B.; Perez, P.; Rander, J.; Renardy, J.-F.; Rosowsky, A.; Roussarie, A.; Schuller, J.-P.; Schwindling, J.; Si Mohand, D.; Vallage, B.; Johnson, R. P.; Litke, A. M.; Taylor, G.; Wear, J.; Ashman, J. G.; Babbage, W.; Booth, C. N.; Buttar, C.; Cartwright, S.; Combley, F.; Dawson, I.; Thompson, L. F.; Barberio, E.; Böhrer, A.; Brandt, S.; Cowan, G.; Grupen, C.; Lutters, G.; Rivera, F.; Schäfer, U.; Smolik, L.; Bosisio, L.; Della Marina, R.; Giannini, G.; Gobbo, B.; Ragusa, F.; Bellantoni, L.; Chen, W.; Conway, J. S.; Feng, Z.; Ferguson, D. P. S.; Gao, Y. S.; Grahl, J.; Harton, J. L.; Hayes, O. J.; Nachtman, J. M.; Pan, Y. B.; Saadi, Y.; Schmitt, M.; Scott, I.; Sharma, V.; Shi, Z. H.; Turk, J. D.; Walsh, A. M.; Weber, F. V.; Sau, Lan, Wu; Wu, X.; Zheng, M.; Zobernig, G.

1993-09-01

A measurement of the partial width ratio Γbb/Γhad using a method which tags the Z --> bb decays through the lif etime of the produced heavy hadrons is presented. This method relies on the tracking precision afforded by a double-sided silicon vertex detector. The tag algorithm makes a probabilistic interpretation of three-dimensional track impact parameters, using the data to measure the resolution. By tagging the two b hadrons separately, both Γbb/Γhad and the tag efficiency can be determined from the data. For a 26% efficiency of tagging a single b hadron within the vertex detector solid angle coverage, a purity of 96% is achieved. A value of Γbb/Γhad = 0.2192+/-0.0026(stat.)+/-0.0016(Γcc/ Γhad) is found. Combining this result with other recent ALEPH Γbb/Γhad measurements gives a 95% confidence upper limit on the Standard Model top mass of Mt < 228 GeV. Supported by the US Department of Energy, contract DE-AC02-76ER00881.

Platelet-Derived Growth Factor BB Influences Muscle Regeneration in Duchenne Muscle Dystrophy.

Science.gov (United States)

Piñol-Jurado, Patricia; Gallardo, Eduard; de Luna, Noemi; Suárez-Calvet, Xavier; Sánchez-Riera, Carles; Fernández-Simón, Esther; Gomis, Clara; Illa, Isabel; Díaz-Manera, Jordi

2017-08-01

Duchenne muscular dystrophy (DMD) is characterized by a progressive loss of muscle fibers, and their substitution by fibrotic and adipose tissue. Many factors contribute to this process, but the molecular pathways related to regeneration and degeneration of muscle are not completely known. Platelet-derived growth factor (PDGF)-BB belongs to a family of growth factors that regulate proliferation, migration, and differentiation of mesenchymal cells. The role of PDGF-BB in muscle regeneration in humans has not been studied. We analyzed the expression of PDGF-BB in muscle biopsy samples from controls and patients with DMD. We performed in vitro experiments to understand the effects of PDGF-BB on myoblasts involved in the pathophysiology of muscular dystrophies and confirmed our results in vivo by treating the mdx murine model of DMD with repeated i.m. injections of PDGF-BB. We observed that regenerating and necrotic muscle fibers in muscle biopsy samples from DMD patients expressed PDGF-BB. In vitro, PDGF-BB attracted myoblasts and activated their proliferation. Analysis of muscles from the animals treated with PDGF-BB showed an increased population of satellite cells and an increase in the number of regenerative fibers, with a reduction in inflammatory infiltrates, compared with those in vehicle-treated mice. Based on our results, PDGF-BB may play a protective role in muscular dystrophies by enhancing muscle regeneration through activation of satellite cell proliferation and migration. Copyright © 2017 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Molecular characterization of a new Babesia bovis thrombospondin-related anonymous protein (BbTRAP2.

Directory of Open Access Journals (Sweden)

Mohamad Alaa Terkawi

Full Text Available A gene encoding a Babesia bovis protein that shares significant degree of similarity to other apicomplexan thrombospondin-related anonymous proteins (TRAPs was found in the genomic database and designated as BbTRAP2. Recombinant protein containing a conserved region of BbTRAP2 was produced in E. coli. A high antigenicity of recombinant BbTRAP2 (rBbTRAP2 was observed with field B. bovis-infected bovine sera collected from geographically different regions of the world. Moreover, antiserum against rBbTRAP2 specifically reacted with the authentic protein by Western blot analysis and an indirect fluorescent antibody test. Three bands corresponding to 104-, 76-, and 44-kDa proteins were identified in the parasite lysates and two bands of 76- and 44-kDa proteins were detected in the supernatant of cultivated parasites, indicating that BbTRAP2 was proteolytically processed and shed into the culture. Apical and surface localizations of BbTRAP2 were observed in the intracellular and extracellular parasites, respectively, by confocal laser microscopic examination. Moreover, native BbTRAP2 was precipitated by bovine erythrocytes, suggesting its role in the attachment to erythrocytes. Furthermore, the specific antibody to rBbTRAP2 inhibited the growth of B. bovis in a concentration-dependent manner. Consistently, pre-incubation of the free merozoites with the antibody to rBbTRAP2 resulted in an inhibition of the parasite invasion into host erythrocytes. Interestingly, the antibody to rBbTRAP2 was the most inhibitive for the parasite's growth as compared to those of a set of antisera produced against different recombinant proteins, including merozoite surface antigen 2c (BbMSA-2c, rhoptry-associated protein 1 C-terminal (BbRAP-1CT, and spherical body protein 1 (BbSBP-1. These results suggest that BbTRAP2 might be a potential candidate for development of a subunit vaccine against B. bovis infection.

INFRARED VARIABILITY OF THE GLIESE 569B SYSTEM

International Nuclear Information System (INIS)

Kenworthy, Matthew A.; Scuderi, Louis J.

2012-01-01

Gliese 569B is a multiple brown dwarf system whose exact nature has been the subject of several investigations over the past few years. Interpretation has partially relied on infrared photometry and spectroscopy of the resolved components of the system. We present seeing-limited K s photometry over four nights, searching for variability in this young low-mass substellar system. Our photometry is consistent with other reported photometry, and we report the tentative detection of several periodic signals consistent with rotational modulation due to spots on their surfaces. The five significant periods range from 2.90 hr to 12.8 hr, with peak-to-peak variabilities from 28 mmag to 62 mmag in the K s band. If both components are rotating with the shortest periods, then their rotation axes are not parallel with each other, and the rotation axis of the Bb component is not perpendicular to the Ba-Bb orbital plane. If Bb has one of the longer rotational periods, then the Bb rotation axis is consistent with being parallel to the orbital axis of the Ba-Bb system.

InterProScan Result: BB993418 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available BB993418 BB993418_6_ORF2 7325F21342D1E3DD PANTHER PTHR12479 LYSOSOMAL-ASSOCIATED TRANSME...MBRANE PROTEIN 1.9e-69 T IPR004687 Golgi 4-transmembrane spanning transporter Biological Process: transport (GO:0006810)|Cellular Component: integral to membrane (GO:0016021) ...

Measure of the e+e-{yields}bb Cross Section at the LEP Energies; Medida de la seccion eficaz e''+e''-{yields}bb a las Energias de LEP

Energy Technology Data Exchange (ETDEWEB)

Arce Dubois, P

1992-07-01

In the present work I analyse the data collected during 1990 by the L3 detector, situated in the electron-positron collider LEP. After selecting the events e''+e''-{yields} bb through their semileptonic decays into muons, I calculate the cross section for the process e''+e''- {yields} bb at different energy points around the mass of the vectorial boson Z, and I measure some parameters of the Standard Model, namely, the Br(b{yields}{mu} ),{gamma}{sub z}n-{yields}bb/{gamma}{sub z}n{yields}had and {gamma}{sub z}n{yields}bb{gamma}{sub z}n{yields}e''+e''-. (Author) 26 refs.

SN 2009bb: A PECULIAR BROAD-LINED TYPE Ic SUPERNOVA ,

International Nuclear Information System (INIS)

Pignata, Giuliano; Stritzinger, Maximilian; Phillips, M. M.; Morrell, Nidia; Boldt, Luis; Campillay, Abdo; Contreras, Carlos; Gonzalez, Sergio; Krzeminski, Wojtek; Roth, Miguel; Salgado, Francisco; Soderberg, Alicia; Mazzali, Paolo; Anderson, J. P.; Folatelli, Gaston; Foerster, Francisco; Hamuy, Mario; Maza, Jose; Levesque, Emily M.; Rest, Armin

2011-01-01

Ultraviolet, optical, and near-infrared photometry and optical spectroscopy of the broad-lined Type Ic supernova (SN) 2009bb are presented, following the flux evolution from -10 to +285 days past B-band maximum. Thanks to the very early discovery, it is possible to place tight constraints on the SN explosion epoch. The expansion velocities measured from near maximum spectra are found to be only slightly smaller than those measured from spectra of the prototype broad-lined SN 1998bw associated with GRB 980425. Fitting an analytical model to the pseudobolometric light curve of SN 2009bb suggests that 4.1 ± 1.9 M sun of material was ejected with 0.22 ± 0.06 M sun of it being 56 Ni. The resulting kinetic energy is 1.8 ± 0.7 x 10 52 erg. This, together with an absolute peak magnitude of M B = -18.36 ± 0.44, places SN 2009bb on the energetic and luminous end of the broad-lined Type Ic (SN Ic) sequence. Detection of helium in the early time optical spectra accompanied with strong radio emission and high metallicity of its environment makes SN 2009bb a peculiar object. Similar to the case for gamma-ray bursts (GRBs), we find that the bulk explosion parameters of SN 2009bb cannot account for the copious energy coupled to relativistic ejecta, and conclude that another energy reservoir (a central engine) is required to power the radio emission. Nevertheless, the analysis of the SN 2009bb nebular spectrum suggests that the failed GRB detection is not imputable to a large angle between the line-of-sight and the GRB beamed radiation. Therefore, if a GRB was produced during the SN 2009bb explosion, it was below the threshold of the current generation of γ-ray instruments.

Methane and Trichloroethylene Oxidation by an Estuarine Methanotroph, Methylobacter sp. Strain BB5.1

OpenAIRE

Smith, Kelly S.; Costello, Andria M.; Lidstrom, Mary E.

1998-01-01

An estuarine methanotroph was isolated from sediment enrichments and designated Methylobacter sp. strain BB5.1. In cells grown on medium with added copper, oxidation of methane and trichloroethylene occurred with similar Ks values, but the Vmax for trichloroethylene oxidation was only 0.1% of the methane oxidation Vmax. Cells grown on low-copper medium did not oxidize trichloroethylene and showed a variable rate of methane oxidation.

Erratum: PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

DEFF Research Database (Denmark)

Cao, R.H.; Bjorndahl, M.A.; Religa, P.

2006-01-01

This corrects the article "PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis", Cancer Cell, 2004, vol. 6(4), pg 333-45.......This corrects the article "PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis", Cancer Cell, 2004, vol. 6(4), pg 333-45....

Resonant Higgs boson pair production in the hh→bb̄ WW→bb̄ℓ{sup +}νℓ{sup −}ν̄ decay channel

Energy Technology Data Exchange (ETDEWEB)

Lozano, Víctor Martín [Instituto de Física Teórica, IFT-UAM/CSIC, UAM Cantoblanco,Nicolás Cabrera 13, 28049 Madrid (Spain); Departamento de Física Teórica, Universidad Autónoma de Madrid,Cantoblanco, E-28049, Madrid (Spain); Moreno, Jesús M. [Instituto de Física Teórica, IFT-UAM/CSIC, UAM Cantoblanco,Nicolás Cabrera 13, 28049 Madrid (Spain); Park, Chan Beom [School of Physics, Korea Institute for Advanced Study,Seoul, 130-722 (Korea, Republic of); TH Division, Physics Department, CERN,CH-1211, Geneve 23 (Switzerland)

2015-08-03

The addition of a scalar singlet provides one of the simplest extensions of the Standard Model. In this work we briefly review the latest constraints on the mass and mixing of the new Higgs boson and study its production and decay at the LHC. We mainly focus on double Higgs production in the hh→bb̄WW→bb̄ℓ{sup +}νℓ{sup −}ν̄ decay channel. This decay is found to be efficient in a region of masses of the heavy Higgs boson of 260–500 GeV, so it is complementary to the 4b channel, more efficient for Higgs bosons with masses greater than 500 GeV. We analyse this di-leptonic decay channel in detail using kinematic variables such as M{sub T2} and the M{sub T2}-assisted on-shell reconstruction of invisible momenta. Using proper cuts, a significance of ∼ 3σ for 3000 fb{sup −1} can be achieved at the 14 TeV LHC for m{sub H}=260–400 GeV if the mixing is close to its present limit and BR(H→hh)≈1. Smaller values for the mixing would require combining various decay channels in order to reach a similar significance. The complementarity among H→hh, H→ZZ and H→WW channels is studied for arbitrary BR(H→hh) values.

Measure of the e+e-→bb Cross Section at the LEP Energies

International Nuclear Information System (INIS)

Arce Dubois, P.

1992-01-01

In the present work I analyse the data collected during 1990 by the L3 detector, situated in the electron-positron collider LEP. After selecting the events e''+e''-→ bb through their semileptonic decays into muons, I calculate the cross section for the process e''+e''- → bb at different energy points around the mass of the vectorial boson Z, and I measure some parameters of the Standard Model, namely, the Br(b→μ ),Γ z n-→bb/Γ z n→had and Γ z n→bbΓ z n→e''+e''-. (Author) 26 refs

THE HIGH-METALLICITY EXPLOSION ENVIRONMENT OF THE RELATIVISTIC SUPERNOVA 2009bb

International Nuclear Information System (INIS)

Levesque, E. M.; Kewley, L. J.; Soderberg, A. M.; Foley, R. J.; Berger, E.; Torres, M. A. P.; Challis, P.; Kirshner, R. P.; Copete, A.; Chakraborti, S.; Ray, A.; Barthelmy, S. D.; Bietenholz, M. F.; Chandra, P.; Chaplin, V.; Connaughton, V.; Chevalier, R. A.; Fox, O.; Chugai, N.; Fransson, C.

2010-01-01

We investigate the environment of the nearby (d ∼ 40 Mpc) broad-lined Type Ic supernova (SN) 2009bb. This event was observed to produce a relativistic outflow likely powered by a central accreting compact object. While such a phenomenon was previously observed only in long-duration gamma-ray bursts (LGRBs), no LGRB was detected in association with SN 2009bb. Using an optical spectrum of the SN 2009bb explosion site, we determine a variety of interstellar medium properties for the host environment, including metallicity, young stellar population age, and star formation rate. We compare the SN explosion site properties to observations of LGRB and broad-lined SN Ic host environments on optical emission line ratio diagnostic diagrams. Based on these analyses, we find that the SN 2009bb explosion site has a metallicity between 1.7 Z sun and 3.5 Z sun , in agreement with other broad-lined SN Ic host environments and at odds with the low-redshift LGRB host environments and recently proposed maximum metallicity limits for relativistic explosions. We consider the implications of these findings and the impact that SN 2009bb's unusual explosive properties and environment have on our understanding of the key physical ingredient that enables some SNe to produce a relativistic outflow.

Very-high-energy gamma-ray observations of pulsar wind nebulae and cataclysmic variable stars with MAGIC and development of trigger systems for IACTs

Science.gov (United States)

Lopez-Coto, Ruben

2015-07-01

lowest possible energy threshold with the LSTs of CTA. Together with this work, the trigger of the MAGIC telescopes was improved. We have simulated, tested and commissioned a new concept of stereoscopic trigger. This new system, that uses the information of the position of the showers on each of the MAGIC cameras, is dubbed "Topo-trigger". The scientific fraction of the thesis deals with galactic sources observed with the MAGIC telescopes. In Part III, I talk about the analysis of the VHE γ-ray emission of Pulsar Wind Nebulae (PWNe): the discovery of VHE γ-ray emission from the puzzling PWN 3C 58, the likely remnant of the SN 1181 AD and the weakest PWN detected at VHE to date; the characterization of the VHE tail of the Crab nebula by observing it at the highest zenith angles; and the search for an additional inverse Compton component during the Crab nebula flares reported by Fermi-LAT in the synchrotron regime. Part IV is concerned with searches for VHE γ-ray emission of cataclysmic variable stars. I studied, on a multiwavelength context, the VHE γ-ray nature of the previously claimed pulsed γ-ray emission of the cataclysmic variable AE Aqr. I also performed observations of novae and a dwarf nova to pinpoint the ac- celeration mechanisms taking place in this kind of objects and to discover a putative hadronic component of the soft γ-ray emission. A conclusion chapter summarizes all the work performed and lists prospects related with the topics treated in this thesis.

Crystal structure of the human 4-1BB/4-1BBL complex.

Science.gov (United States)

Gilbreth, Ryan N; Oganesyan, Vaheh Y; Amdouni, Hamza; Novarra, Shabazz; Grinberg, Luba; Barnes, Arnita; Baca, Manuel

2018-05-02

4-1BBL is a member of the TNF superfamily and is the ligand for the TNFRsuperfamily receptor, 4-1BB. 4-1BB plays an immunomodulatory role in T cells and NK cells and agonists of this receptor have garnered strong attention as potentialimmunotherapy agents. Broadly speaking, the structural features of TNF superfamilymembers, their receptors and ligand/receptor complexes are similar. However, apublished crystal structure of human 4-1BBL suggests that it may be unique in thisregard, exhibiting a three-bladed propeller-like trimer assembly that is distinctly different from that observed in other family members. This unusual structure also suggests that the human 4-1BB/4-1BBL complex may be structurally unique within the TNF/TNFR superfamily, but to date no structural data have been reported. Here we report the crystal structure of the human 4-1BB/4-1BBL complex at 2.4 Å resolution. In this structure, 4-1BBL does not adopt the unusual trimer assembly previously reported, but instead forms a canonical bell-shaped trimer typical of other TNF superfamily members. The structure of 4-1BB is also largely canonical as is the 4-1BB/4-1BBL complex. Mutational data support the 4-1BBL structure reported here as being biologically relevant, suggesting that the previously reported structure is not. Together, the data presented here offer insight into structure/function relationships in the 4-1BB/4-1BBL system and improve our structural understanding of the TNF/TNFR superfamily more broadly. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

Differences in acid tolerance between Bifidobacterium breve BB8 and its acid-resistant derivative B. breve BB8dpH, revealed by RNA-sequencing and physiological analysis.

Science.gov (United States)

Yang, Xu; Hang, Xiaomin; Tan, Jing; Yang, Hong

2015-06-01

Bifidobacteria are common inhabitants of the human gastrointestinal tract, and their application has increased dramatically in recent years due to their health-promoting effects. The ability of bifidobacteria to tolerate acidic environments is particularly important for their function as probiotics because they encounter such environments in food products and during passage through the gastrointestinal tract. In this study, we generated a derivative, Bifidobacterium breve BB8dpH, which displayed a stable, acid-resistant phenotype. To investigate the possible reasons for the higher acid tolerance of B. breve BB8dpH, as compared with its parental strain B. breve BB8, a combined transcriptome and physiological approach was used to characterize differences between the two strains. An analysis of the transcriptome by RNA-sequencing indicated that the expression of 121 genes was increased by more than 2-fold, while the expression of 146 genes was reduced more than 2-fold, in B. breve BB8dpH. Validation of the RNA-sequencing data using real-time quantitative PCR analysis demonstrated that the RNA-sequencing results were highly reliable. The comparison analysis, based on differentially expressed genes, suggested that the acid tolerance of B. breve BB8dpH was enhanced by regulating the expression of genes involved in carbohydrate transport and metabolism, energy production, synthesis of cell envelope components (peptidoglycan and exopolysaccharide), synthesis and transport of glutamate and glutamine, and histidine synthesis. Furthermore, an analysis of physiological data showed that B. breve BB8dpH displayed higher production of exopolysaccharide and lower H(+)-ATPase activity than B. breve BB8. The results presented here will improve our understanding of acid tolerance in bifidobacteria, and they will lead to the development of new strategies to enhance the acid tolerance of bifidobacterial strains. Copyright © 2015 Elsevier Ltd. All rights reserved.

In vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review

Directory of Open Access Journals (Sweden)

O Evrova

2017-07-01

Full Text Available To promote and support tendon healing, one viable strategy is the use or administration of growth factors at the wound/rupture site. Platelet derived growth factor-BB (PDGF-BB, together with other growth factors, is secreted by platelets after injury. PDGF-BB promotes mitogenesis and angiogenesis, which could accelerate tendon healing. Therefore, in vitro studies with PDGF-BB have been performed to determine its effect on tenocytes and tenoblasts. Moreover, accurate and sophisticated drug delivery devices, aiming for a sustained release of PDGF-BB, have been developed, either by using heparin-binding and fibrin-based matrices or different electrospinning techniques. In this review, the structure and composition, as well as the healing process of tendons, are described. Part A deals with in vitro studies. They focus on the multiple effects evoked by PDGF-BB on the cellular level. Moreover, they address strategies for the sustained delivery of PDGF-BB. Part B focuses on animal models used to test different delivery strategies for PDGF-BB, in the context of tendon reconstruction. These studies showed that dosage and timing of PDGF-BB application are the most important factors for deciding which delivery device should be applied for a specific tendon laceration.

Cataclysm No More: New Views on the Timing and Delivery of Lunar Impactors.

Science.gov (United States)

Zellner, Nicolle E B

2017-09-01

If properly interpreted, the impact record of the Moon, Earth's nearest neighbour, can be used to gain insights into how the Earth has been influenced by impacting events since its formation ~4.5 billion years (Ga) ago. However, the nature and timing of the lunar impactors - and indeed the lunar impact record itself - are not well understood. Of particular interest are the ages of lunar impact basins and what they tell us about the proposed "lunar cataclysm" and/or the late heavy bombardment (LHB), and how this impact episode may have affected early life on Earth or other planets. Investigations of the lunar impactor population over time have been undertaken and include analyses of orbital data and images; lunar, terrestrial, and other planetary sample data; and dynamical modelling. Here, the existing information regarding the nature of the lunar impact record is reviewed and new interpretations are presented. Importantly, it is demonstrated that most evidence supports a prolonged lunar (and thus, terrestrial) bombardment from ~4.2 to 3.4 Ga and not a cataclysmic spike at ~3.9 Ga. Implications for the conditions required for the origin of life are addressed.

Restriction fragment polymorphisms in the major histocompatibility complex of diabetic BB rats

DEFF Research Database (Denmark)

Kastern, W.; Dyrberg, T.; Scholler, J.

1984-01-01

DNA isolated from diabetic BB (BB/Hagedorn) rats was examined for restriction fragment length differences within the major histocompatibility complex (MHC) as compared with nondiabetic (W-subline) BB rats. Polymorphisms were detected using a mouse class I MHC gene as probe. Specifically, a 2-kb Bam......HI fragment was present in all the nondiabetic rats examined, but absent in the diabetic rats. Similar polymorphisms were observed with various other restriction enzymes, particularly XbaI, HindII, and SacI. There were no polymorphisms detected using either a human DR-alpha (class II antigen heavy chain...

Perbandingan antara Tramadol 2 mg/kgBB dan Fentanil 2 mg/kgBB Intravena Sebagai Analgetik Intraoperatif pada Operasi Laparotomi Ginekologis; Pengaruhnya terhadap Skor PRST

Directory of Open Access Journals (Sweden)

Arief Kurniawan

2017-12-01

Full Text Available Perkembangan dan kemajuan teknologi serta ilmu pengetahuan telah mendorong pelaksanaan pelayanan kesehatan yang lebih efektif dan lebih ekonomis dibanding dengan cara yang lazim dikerjakan. Telah dilakukan penelitian terhadap 32 pasien operasi laparotomi ginekologis yang dibagi menjadi dua kelompok. Kelompok Tramadol (n=16 diberikan tramadol 2 mg/kgBB (pengenceran akuabides sampai 10 mL lewat jalur infus selama satu menit, sedangkan pada kelompok Fentanil (n=16 diberikan fentanil 2 µg/kgBB dengan cara yang sama. Lima menit kemudian diberikan propofol 2 mg/kgBB, atrakurium 0,5 mg/kgBB, enfluran 2 volume %, N2O:O2=2 L/menit:2 L/menit. Setelah tiga menit dilakukan laringoskopi intubasi. Pasien diventilasi kendali dengan mode ventilator IPPV. Operasi dilaksanakan bila kedalaman anestesi tercapai berdasar atas skor PRST (P=systolic arterial pressure, R=heart rate, S=sweat, dan T=tears 2 sampai dengan 4. Analgetik pertolongan 50 µg fentanil diberikan bila skor PRST lebih dari 4. Analgetik postoperatif 30 mg ketorolak dan antimuntah 10 mg metoklopramid diberikan saat jahit kulit. Pencatatan tekanan darah, laju nadi, saturasi O2, dan skor PRST dilakukan sebagai berikut: T0 = penderita tiba di kamar operasi, T1= preintubasi, T2= satu menit setelah intubasi, T3= satu menit setelah insisi, T4 dan seterusnya diukur tiap 15 menit sampai selesai operasi. Pasien diekstubasi setelah pernapasan adekuat. Skala sedasi dan muntah dinilai setiap 15 menit setelah ekstubasi selama dua jam. Dari hasil penelitian didapatkan skor PRST mulai T1 sampai T12 secara statistis tidak berbeda bermakna antara kelompok tramadol dan fentanil (p>0,05. Kedua kelompok mengalami peningkatan skor PRST satu menit setelah intubasi. Skor PRST dipertahankan antara 0 sampai 2. Pada kelompok tramadol dan fentanil masing-masing satu orang mendapatkan analgetik pertolongan fentanil 50 µg karena skor PRST 5. Tidak ditemukan perbedaan skala sedasi dan muntah antara dua kelompok perlakuan

Measure of the e+e-{yields}bb Cross Section at the LEP Energies; Medida de la seccion eficaz e''+e''-{yields}bb a las Energias de LEP

Energy Technology Data Exchange (ETDEWEB)

Arce Dubois, P.

1992-07-01

In the present work I analyse the data collected during 1990 by the L3 detector, situated in the electron-positron collider LEP. After selecting the events e''+e''-{yields} bb through their semileptonic decays into muons, I calculate the cross section for the process e''+e''- {yields} bb at different energy points around the mass of the vectorial boson Z, and I measure some parameters of the Standard Model, namely, the Br(b{yields}{mu} ),{gamma}{sub z}n-{yields}bb/{gamma}{sub z}n{yields}had and {gamma}{sub z}n{yields}bb{gamma}{sub z}n{yields}e''+e''-. (Author) 26 refs.

Elevated platelet-derived growth factor-BB concentrations in premature neonates who develop chronic lung disease

Directory of Open Access Journals (Sweden)

Adcock Kim G

2004-06-01

Full Text Available Abstract Background Chronic lung disease (CLD in the preterm newborn is associated with inflammation and fibrosis. Platelet-derived growth factor-BB (PDGF-BB, a potent chemotactic growth factor, may mediate the fibrotic component of CLD. The objectives of this study were to determine if tracheal aspirate (TA concentrations of PDGF-BB increase the first 2 weeks of life in premature neonates undergoing mechanical ventilation for respiratory distress syndrome (RDS, its relationship to the development of CLD, pulmonary hemorrhage (PH and its relationship to airway colonization with Ureaplasma urealyticum (Uu. Methods Infants with a birth weight less than 1500 grams who required mechanical ventilation for RDS were enrolled into this study with parental consent. Tracheal aspirates were collected daily during clinically indicated suctioning. Uu cultures were performed on TA collected in the first week of life. TA supernatants were assayed for PDGF-BB and secretory component of IgA concentrations using ELISA techniques. Results Fifty premature neonates were enrolled into the study. Twenty-eight infants were oxygen dependent at 28 days of life and 16 infants were oxygen dependent at 36 weeks postconceptual age. PDGF-BB concentrations peaked between 4 and 6 days of life. Maximum PDGF-BB concentrations were significantly higher in infants who developed CLD or died from respiratory failure. PH was associated with increased risk of CLD and was associated with higher PDGF-BB concentrations. There was no correlation between maximum PDGF-BB concentrations and Uu isolation from the airway. Conclusions PDGF-BB concentrations increase in TAs of infants who undergo mechanical ventilation for RDS during the first 2 weeks of life and maximal concentrations are greater in those infants who subsequently develop CLD. Elevation in lung PDGF-BB may play a role in the development of CLD.

Measure of the e+e-→ bb-bar cross section at the LEP energies

International Nuclear Information System (INIS)

Arce Dubois, P.

1992-01-01

In the present work I analyse the data collected during 1990 by the L3 detector, situated in the electron-positron collider LEP. After selecting the events e + e - → bb-bar through their semileptonic decays into muons, I calculate the cross section for the process e + e - → bb-bar at different energy points around the mass of the vectorial Z 0 , and I measure some parameters of the Standard Model, namely the Br(b→μ),γ Z degree celsius →bb/γ Z degree celsius → had and γ Z degree celsius → bb γ Z degree celsius → e + e -

EST Table: BB985913 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available ar to putative lysosomal glucocerebrosidase [Tribolium castaneum] 10/08/28 30 %/249 aa FBpp0129766|DereGG112...EDICTED: similar to putative lysosomal glucocerebrosidase [Tribolium castaneum] BB985877 MSV3 ...

4-1BB Aptamer-Based Immunomodulation Enhances the Therapeutic Index of Radiation Therapy in Murine Tumor Models

Energy Technology Data Exchange (ETDEWEB)

Benaduce, Ana Paula; Brenneman, Randall; Schrand, Brett; Pollack, Alan; Gilboa, Eli; Ishkanian, Adrian, E-mail: aishkanian@med.miami.edu

2016-10-01

Purpose: To report a novel strategy using oligonucleotide aptamers to 4-1BB as an alternate method for costimulation, and show that combinatorial therapy with radiation improves the therapeutic ratio over equivalent monoclonal antibodies. Methods and Materials: Subcutaneous 4T1 (mouse mammary carcinoma) tumors were established (approximately 100 mm{sup 3}), and a radiation therapy (RT) dose/fractionation schedule that optimally synergizes with 4-1BB monoclonal antibody (mAb) was identified. Comparable tumor control and animal survival was observed when either 4-1BB antibody or aptamer were combined with RT using models of breast cancer and melanoma (4T1 and B16-F10). Off-target CD8{sup +} T-cell toxicity was evaluated by quantification of CD8{sup +} T cells in livers and spleens of treated animals. Results: When combined with 4-1BB mAb, significant differences in tumor control were observed by varying RT dose and fractionation schedules. Optimal synergy between RT and 4-1BB mAb was observed at 5 Gy × 6. Testing 4-1BB mAb and aptamer independently using the optimal RT (5 Gy × 6 for 4T1/Balb/c and 12 Gy × 1 for B16/C57BL6J mouse models) revealed equivalent tumor control using 4-1BB aptamer and 4-1BB mAb. 4-1BB mAb, but not 4-1BB aptamer-treated animals, exhibited increased lymphocytic liver infiltrates and increased splenic and liver CD8{sup +} T cells. Conclusions: Radiation therapy synergizes with 4-1BB mAb, and this effect is dependent on RT dose and fractionation. Tumor control by 4-1BB aptamer is equivalent to 4-1BB mAb when combined with optimal RT dose, without eliciting off-target liver and spleen CD8{sup +} expansion. 4-1BB aptamer-based costimulation affords a comparable and less toxic strategy to augment RT-mediated tumor control.

An investigation of hierachical protein recruitment to the inhibitory platelet receptor, G6B-b.

Directory of Open Access Journals (Sweden)

Carmen H Coxon

Full Text Available Platelet activation is regulated by both positive and negative signals. G6B-b is an inhibitory platelet receptor with an immunoreceptor tyrosine-based inhibitory motif (ITIM and an immunoreceptor tyrosine-based switch motif (ITSM. The molecular basis of inhibition by G6B-b is currently unknown but thought to involve the SH2 domain-containing tyrosine phosphatase SHP-1. Here we show that G6B-b also associates with SHP-2, as well as SHP-1, in human platelets. Using a number of biochemical approaches, we found these interactions to be direct and that the tandem SH2 domains of SHP-2 demonstrated a binding affinity for G6B-b 100-fold higher than that of SHP-1. It was also observed that while SHP-1 has an absolute requirement for phosphorylation at both motifs to bind, SHP-2 can associate with G6B-b when only one motif is phosphorylated, with the N-terminal SH2 domain and the ITIM being most important for the interaction. A number of other previously unreported SH2 domain-containing proteins, including Syk and PLCγ2, also demonstrated specificity for G6B-b phosphomotifs and may serve to explain the observation that G6B-b remains inhibitory in the absence of both SHP-1 and SHP-2. In addition, the presence of dual phosphorylated G6B-b in washed human platelets can reduce the EC(50 for both CRP and collagen.

Categorization of the processes contributing to ttH(H→bb) using deep neural networks with the CMS experiment

Energy Technology Data Exchange (ETDEWEB)

Rath, Yannik; Erdmann, Martin; Fischer, Benjamin; Fischer, Robert; Heidemann, Fabian; Quast, Thorben; Rieger, Marcel [III. Physikalisches Institut A, RWTH Aachen University (Germany)

2016-07-01

In ttH(H→bb) analyses, event categorization is introduced to simultaneously constrain signal and background processes. A common procedure is to categorize events according to both their jet and b-tag multiplicities. The separation power of this approach is limited by the b-tagging efficiency. Especially ttH(H→bb) events with their high b-tag multiplicities suffer from migrations to background categories. In this presentation, we explore deep neural networks (DNNs) as a method of categorizing events according to their jet multiplicity and a DNN event class hypothesis. DNNs have the advantage of being able to learn discriminating features from low level variables, e.g. kinematic properties, and are naturally suited for multiclass classification problems. We compare the ttH signal separation achieved with the DNN method with that of a common categorization approach.

Fetal rat pancreas transplantation in BB rats: immunohistochemical and functional evaluation

DEFF Research Database (Denmark)

Yderstræde, Knud Bonnet; Starklint, Henrik; Steinbrüchel, Daniel Andreas

1993-01-01

Spontaneously diabetic BB/Wor rats received either a syngeneic fetal pancreas transplant or adult islets. In the former, 4-8 fetal pancreases were transplanted, and in the latter, 3-5000 islets. Transplantation was performed by transferring a blood clot containing the pancreases or islets...... to the renal subcapsular space. Insulin therapy was undertaken postoperatively, except in one experiment with adult islets. Of the fetal pancreas transplanted BB rats, 52% became normoglycaemic, and 21% remained so throughout an observation period of 10 months. Nephrectomy caused a prompt return of diabetes...... that recurrent diabetes is not inevitable following syngeneic fetal pancreas transplantation to spontaneously diabetic BB rats. Recurrent diabetes was only occasionally associated with mononuclear cell infiltration. Transplanted tissue was well-preserved and vascularized; mega-islets were a constant finding....

Measurement of the ratio of branching fractions ${\\cal B}(B^0 \\to K^{\\ast 0} \\gamma)/{\\cal B}(B^0_s \\to \\phi \\gamma)$

CERN Document Server

Aaij, R; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amhis, Y; Anderson, J; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Arrabito, L; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Bailey, D S; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bates, A; Bauer, C; Bauer, Th; Bay, A; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blanks, C; Blouw, J; Blusk, S; Bobrov, A; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Büchler-Germann, A; Burducea, I; Bursche, A; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chiapolini, N; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Collins, P; Comerma-Montells, A; Constantin, F; Contu, A; Cook, A; Coombes, M; Corti, G; Couturier, B; Cowan, G A; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Lorenzi, F; De Miranda, J M; De Paula, L; De Simone, P; Decamp, D; Deckenhoff, M; Degaudenzi, H; Del Buono, L; Deplano, C; Derkach, D; Deschamps, O; Dettori, F; Dickens, J; Dijkstra, H; Diniz Batista, P; Domingo Bonal, F; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisele, F; Eisenhardt, S; Ekelhof, R; Eklund, L; Elsasser, Ch; Elsby, D; Esperante Pereira, D; Falabella, A; Fanchini, E; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Fernandez Albor, V; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garnier, J-C; Garofoli, J; Garra Tico, J; Garrido, L; Gascon, D; Gaspar, C; Gauld, R; Gauvin, N; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hampson, T; Hansmann-Menzemer, S; Harji, R; Harnew, N; Harrison, J; Harrison, P F; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Holubyev, K; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Huston, R S; Hutchcroft, D; Hynds, D; Iakovenko, V; Ilten, P; Imong, J; Jacobsson, R; Jaeger, A; Jahjah Hussein, M; Jans, E; Jansen, F; Jaton, P; Jean-Marie, B; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Keaveney, J; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kim, Y M; Knecht, M; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kruzelecki, K; Kucharczyk, M; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leroy, O; Lesiak, T; Li, L; Li Gioi, L; Lieng, M; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Luisier, J; Mac Raighne, A; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Magnin, J; Malde, S; Mamunur, R M D; Manca, G; Mancinelli, G; Mangiafave, N; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinez Santos, D; Massafferri, A; Mathe, Z; Matteuzzi, C; Matveev, M; Maurice, E; Maynard, B; Mazurov, A; McGregor, G; McNulty, R; Meissner, M; Merk, M; Merkel, J; Messi, R; Miglioranzi, S; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Musy, M; Mylroie-Smith, J; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Nedos, M; Needham, M; Neufeld, N; Nguyen, A D; Nguyen-Mau, C; Nicol, M; Niess, V; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palacios, J; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Paterson, S K; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petrella, A; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pie Valls, B; Pietrzyk, B; Pilař, T; Pinci, D; Plackett, R; Playfer, S; Plo Casasus, M; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodrigues, F; Rodriguez Perez, P; Rogers, G J; Roiser, S; Romanovsky, V; Rosello, M; Rouvinet, J; Ruf, T; Ruiz, H; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santinelli, R; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schleich, S; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Sobczak, K; Soler, F J P; Solomin, A; Soomro, F; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tsaregorodtsev, A; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urquijo, P; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Viaud, B; Videau, I; Vieira, D; Vilasis-Cardona, X; Visniakov, J; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Voss, H; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Witzeling, W; Wotton, S A; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhong, L; Zvyagin, A

2012-01-01

The ratio of branching fractions of the radiative $B$ decays $B^0\\to K^{*0}\\gamma$ and $B^0_s\\to \\phi\\gamma$ has been measured using $0.37\\,$fb$^{-1}$ of $pp$ collisions at a centre of mass energy of $\\sqrt{s}=7\\,$TeV, collected by the LHCb experiment. The value obtained is \\begin{equation} \\frac{{\\cal B}(B^0\\to K^{*0}\\gamma)}{{\\cal B}(B^0_s\\to \\phi\\gamma)} = 1.12 \\pm 0.08^{+0.06}_{-0.04}\\phantom{.}^{+0.09}_{-0.08},\

Phase I trial of RV3-BB rotavirus vaccine: a human neonatal rotavirus vaccine.

Science.gov (United States)

Danchin, M; Kirkwood, C D; Lee, K J; Bishop, R F; Watts, E; Justice, F A; Clifford, V; Cowley, D; Buttery, J P; Bines, J E

2013-05-28

RV3 is a human neonatal rotavirus strain (G3P[6]) that has been associated with asymptomatic neonatal infection and replicates well in the infant gut. RV3-BB rotavirus vaccine has been developed as a rotavirus vaccine candidate for administration at birth. A single-centre, double-blind, randomised placebo-controlled Phase I study evaluated the safety and tolerability of a single oral dose of the second generation RV3-BB rotavirus vaccine (8.3×10(6)FFU/mL) in 20 adults, 20 children and 20 infants (10 vaccine and 10 placebo per age cohort). Vaccine take was defined as seroconversion (a 3-fold increase in serum anti-rotavirus IgA or serum neutralising antibody (SNA) from baseline at day 28 post-dose) or evidence of RV3-BB viral replication in the faeces by RT-PCR analysis 3-6 days post-vaccination. RV3-BB presence was confirmed by sequence analysis. The RV3-BB vaccine was well tolerated in all participants, with no pattern of adverse events shown to be associated with the study vaccine. In the infant cohort, vaccine take was demonstrated in 8/9 infants following a single dose of vaccine compared with 2/7 placebo recipients. In the infant vaccine group, 5/9 infants exhibited either IgA or SNA seroconversion and 7/9 infants had evidence of RV3-BB replication on days 3-6, compared with 2/7 infants who seroconverted and 0/10 infants with evidence of replication in the placebo group. Two infants in the placebo group had serological evidence of a rotavirus infection within the 28-day study period: one demonstrated an IgA and the other an SNA response, with wild-type virus replication detected in another infant. A single dose of RV3-BB rotavirus vaccine was well tolerated in adults, children and infants. Most infants (8/9) who received RV3-BB demonstrated vaccine take following a single dose. These data support progression of RV3-BB to Phase II immunogenicity and efficacy trials. Copyright © 2013 Elsevier Ltd. All rights reserved.

EST Table: BB985877 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available 13 aa ref|XP_975608.1| PREDICTED: similar to putative lysosomal glucocerebrosidas...el|GB10584-PA 10/09/10 43 %/213 aa gi|91087345|ref|XP_975608.1| PREDICTED: similar to putative lysosomal glucocerebrosidase [Tribolium castaneum] BB985877 MSV3 ...

Polarimetry of magnetic catalysmic variables

Energy Technology Data Exchange (ETDEWEB)

Cropper, M

1985-01-01

The design and construction of an astronomical polarimeter is described and an evaluation made of its performance. Extensive observations of cataclysmic variables with emphasis on the AM Her and DQ Her classes are then presented. The polarimeter permitted simultaneous linear and circular polarisation measurements, or, by rearranging the order of the retarders in the beam, linear polarisation measurements alone, or circular polarisation measurements alone, with enhanced efficiency. Extensive sets of observations using the polarimeter were obtained for six of the ten AM Her variables. A comparison was made between the competing models for the cyclotron emission, showing that those which take into account the temperature structure of the accretion region provide the best results.

Radioimmunoassay of serum creatine kinase BB as index of brain damage after head injury

Energy Technology Data Exchange (ETDEWEB)

Phillips, J P; Jones, H M; Hitchcock, R; Adams, N; Thompson, R J [Addenbrooke' s Hospital, Cambridge (UK)

1980-09-20

Brain-type creatine kinase isoenzyme (CK-BB) was measured by radioimmunoassay in the serum of 54 patients with head injuries. CK-BB was not detectable in 476 out of 1006 controls, the remaining 530 normal samples containing a mean of 1.5 +- SDO.75 ..mu..g/l. The mean CK-BB concentrations in patients with mild, moderate, and fatal head injuries were all significantly higher than the control value (p<0.01 in each instance). Patients with serious head injury had serum concentrations many times the normal value, in two cases within 30 minutes after impact. Fatally injured patients continued to have high serum concentrations several days after injury. In less serious cases values approached normal within two or three days. Every patient with evidence of cerebral laceration, bruising, or swelling had a serum CK-BB concentration above normal. Raised concentrations were found in 14 out of 22 patients with concussion only. Thus the serum CK-BB concentration appears to be a sensitive index of brain damage and may prove useful in the management and follow-up of head-injured patients.

Radioimmunoassay of serum creatine kinase BB as index of brain damage after head injury

International Nuclear Information System (INIS)

Phillips, J.P.; Jones, H.M.; Hitchcock, R.; Adams, N.; Thompson, R.J.

1980-01-01

Brain-type creatine kinase isoenzyme (CK-BB) was measured by radioimmunoassay in the serum of 54 patients with head injuries. CK-BB was not detectable in 476 out of 1006 controls, the remaining 530 normal samples containing a mean of 1.5 +- SDO.75 μg/l. The mean CK-BB concentrations in patients with mild, moderate, and fatal head injuries were all significantly higher than the control value (p<0.01 in each instance). Patients with serious head injury had serum concentrations many times the normal value, in two cases within 30 minutes after impact. Fatally injured patients continued to have high serum concentrations several days after injury. In less serious cases values approached normal within two or three days. Every patient with evidence of cerebral laceration, bruising, or swelling had a serum CK-BB concentration above normal. Raised concentrations were found in 14 out of 22 patients with concussion only. Thus the serum CK-BB concentration appears to be a sensitive index of brain damage and may prove useful in the management and follow-up of head-injured patients. (author)

Search for new resonances decaying to a W or Z boson and a Higgs boson in the ℓ+ℓ−bb¯, ℓνbb¯, and νν¯bb¯ channels with pp collisions at s=13 TeV with the ATLAS detector

Directory of Open Access Journals (Sweden)

M. Aaboud

2017-02-01

Full Text Available A search is presented for new resonances decaying to a W or Z boson and a Higgs boson in the ℓ+ℓ−bb¯, ℓνbb¯, and νν¯bb¯ channels in pp collisions at s=13 TeV with the ATLAS detector at the Large Hadron Collider using a total integrated luminosity of 3.2 fb−1. The search is conducted by looking for a localized excess in the WH/ZH invariant or transverse mass distribution. No significant excess is observed, and the results are interpreted in terms of constraints on a simplified model based on a phenomenological Lagrangian of heavy vector triplets.

Nitrogen Rate Effects on Cry3Bb1 and Cry3Bb1 + Cry34/35Ab1 Expression in Transgenic Corn Roots, Resulting Root Injury, and Corn Rootworm Beetle Emergence.

Science.gov (United States)

Leaf, T M; Ostlie, K R

2017-06-01

Nitrogen (N) application rates have been recommended historically for maximum economic yield of corn (Zea mays L.), but not for optimal expression or impacts of Bt (Bacillus thuringiensis Berliner) Cry protein(s) on target insects. This study explored the need to adjust N rates to optimize expression of corn rootworm-active Bt (Bt-RW) protein(s) in a single and a pyramided trait hybrid and resulting impacts on beetle emergence and root injury, under field conditions. The experiment featured a factorial treatment arrangement in a split-plot randomized complete block design with six N rates as the main plots and three hybrids (MON88017 expressing Cry3Bb1, MON88017 x DAS-59122 expressing Cry3Bb1 + Cry34/35Ab1, and a non-Bt-RW hybrid) as the subplots. Corn roots were sampled at the beginning of, and after, peak larval feeding to determine Bt-expression levels using an enzyme-linked immunosorbent assay. Beetles were collected every 2-3 d during emergence using cut-plant emergence cages. Cry3Bb1 expression was significantly reduced when little or no N was applied. Cry34Ab1 and Cry35Ab1 expression was highly variable and unaffected by N rate. Beetle emergence increased with N rate in the non-Bt-RW hybrid while root injury declined. Provided Bt-RW hybrids had sufficient applied N, root injury was relatively low. Results indicate that N management could affect Bt-RW expression and success of insect resistance management plans provided N is applied at rates that enhance production of susceptible beetles emerging from the non-Bt-RW (refuge) hybrid, and achieve optimal expression and efficacy of Bt traits. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Safety of recombinant human platelet-derived growth factor-BB in Augment® Bone Graft

Directory of Open Access Journals (Sweden)

Luis A Solchaga

2012-12-01

Full Text Available This article discusses nonclinical and clinical data regarding the safety of recombinant human platelet-derived growth factor-BB as a component of the Augment® Bone Graft (Augment. Augment is a bone graft substitute intended to be used as an alternative to autologous bone graft in the fusion of hindfoot and ankle joints. Nonclinical studies included assessment of the pharmacokinetic profile of intravenously administered recombinant human platelet-derived growth factor-BB in rat and dog, effects of intravenous administration of recombinant human platelet-derived growth factor-BB in a reproductive and development toxicity study in rats, and chronic toxicity and carcinogenicity of Augment in a 12-month implantation model. These studies showed that systemic exposure was brief and clearance was rapid. No signs of toxicity, carcinogenicity, or tumor promotion were observed even with doses far exceeding the maximum clinical dose. Results of clinical trials (605 participants and commercial use of recombinant human platelet-derived growth factor-BB containing products indicate that these products are not associated with increased incidence of adverse events or cancer. The safety data presented provide evidence that recombinant human platelet-derived growth factor-BB is a safe therapeutic when used in combination products as a single administration during surgical procedures for bone repair and fusion. There is no evidence associating use of recombinant human platelet-derived growth factor-BB in Augment with chronic toxicity, carcinogenicity, or tumor promotion.

EST Table: BB982318 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available BB982318 ovS3005A12r 10/09/28 68 %/119 aa ref|XP_002092422.1| GE14184 [Drosophila yakuba] gb|EDW92134.1| GE1...4184 [Drosophila yakuba] 10/08/28 68 %/119 aa FBpp0259194|DyakGE14184-PA 10/08/27 3

The inter-outburst behavior of cataclysmic variables

International Nuclear Information System (INIS)

Szkody, P.; Mattei, J.A.; Waagen, E.O.; Stablein, C.

1990-01-01

Existing International Ultraviolet Explorer (IUE) and American Association of Variable Star Observers (AAVSO) archive data was used to accomplish a large scale study of what happens to the ultraviolet flux of accretion disk systems during the quiescent intervals between outbursts and how it relates to the preceding outburst characteristics of amplitude and width. The data sample involved multiple IUE observations for 16 dwarf novae and 8 novae along with existing optical coverage. Results indicate that most systems show correlated ultraviolet (UV) flux behavior with interoutburst phase, with 60 percent of the dwarf novae and 50 percent of the novae having decreasing flux trends while 33 percent of the dwarf novae and 38 percent of the novae show rising UV flux during the quiescent interval. All of the dwarf novae with decreasing UV fluxes at 1475A have orbital periods longer than 4.4 hours, while all (except BV Cen) with flat or rising fluxes at 1475A have orbital periods less than two hours. There are not widespread correlations of the UV fluxes with the amplitude of the preceding outburst and no correlations with the width of the outburst. From a small sample (7) that have relatively large quiescent V magnitude changes between the IUE observations, most show a strong correlation between the UV and optical continuum. Interpretation of the results is complicated by not being able to determine how much the white dwarf contributes to the ultraviolet flux. However, it is now evident that noticeable changes are occurring in the hot zones in accreting systems long after the outburst, and not only for systems that are dominated by the white dwarf. Whether these differences are due to different outburst mechanisms or to changes on white dwarfs which provide varying contributions to the UV flux remains to be determined

The Plant-Derived Bauhinia bauhinioides Kallikrein Proteinase Inhibitor (rBbKI Attenuates Elastase-Induced Emphysema in Mice

Directory of Open Access Journals (Sweden)

Bruno Tadeu Martins-Olivera

2016-01-01

Full Text Available Background. Elastase mediates important oxidative actions during the development of chronic obstructive pulmonary disease (COPD. However, few resources for the inhibition of elastase have been investigated. Our study evaluated the ability of the recombinant plant derived Bauhinia bauhinioides Kallikrein proteinase Inhibitor (rBbKI to modulate elastase-induced pulmonary inflammation. Methods. C57Bl/6 mice were given intratracheal elastase (ELA group or saline (SAL group and were treated intraperitoneally with rBbKI (ELA-rBbKI and SAL-rBbKI groups. At day 28, the following analyses were performed: (I lung mechanics, (II exhaled nitric oxide (ENO, (III bronchoalveolar lavage fluid (BALF, and (IV lung immunohistochemical staining. Results. In addition to decreasing mechanical alterations and alveolar septum disruption, rBbKI reduced the number of cells in the BALF and decreased the cellular expression of TNF-α, MMP-9, MMP-12, TIMP-1, eNOS, and iNOS in airways and alveolar walls compared with the ELA group. rBbKI decreased the volume proportion of 8-iso-PGF2α, collagen, and elastic fibers in the airways and alveolar walls compared with the ELA group. A reduction in the number of MUC-5-positive cells in the airway walls was also observed. Conclusion. rBbKI reduced elastase-induced pulmonary inflammation and extracellular matrix remodeling. rBbKI may be a potential pharmacological tool for COPD treatment.

Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice

Directory of Open Access Journals (Sweden)

Rafael Almeida-Reis

2017-01-01

Full Text Available Background. Proteinases play a key role in emphysema. Bauhinia bauhinioides cruzipain inhibitor (BbCI is a serine-cysteine proteinase inhibitor. We evaluated BbCI treatment in elastase-induced pulmonary alterations. Methods.  C57BL/6 mice received intratracheal elastase (ELA group or saline (SAL group. One group of mice was treated with BbCI (days 1, 15, and 21 after elastase instillation, ELABC group. Controls received saline and BbCI (SALBC group. After 28 days, we evaluated respiratory mechanics, exhaled nitric oxide, and bronchoalveolar lavage fluid. In lung tissue we measured airspace enlargement, quantified neutrophils, TNFα-, MMP-9-, MMP-12-, TIMP-1-, iNOS-, and eNOS-positive cells, 8-iso-PGF2α, collagen, and elastic fibers in alveolar septa and airways. MUC-5-positive cells were quantified only in airways. Results. BbCI reduced elastase-induced changes in pulmonary mechanics, airspace enlargement and elastase-induced increases in total cells, and neutrophils in BALF. BbCI reduced macrophages and neutrophils positive cells in alveolar septa and neutrophils and TNFα-positive cells in airways. BbCI attenuated elastic and collagen fibers, MMP-9- and MMP-12-positive cells, and isoprostane and iNOS-positive cells in alveolar septa and airways. BbCI reduced MUC5ac-positive cells in airways. Conclusions. BbCI improved lung mechanics and reduced lung inflammation and airspace enlargement and increased oxidative stress levels induced by elastase. BbCI may have therapeutic potential in chronic obstructive pulmonary disease.

Structure of the vitreoretinal border region in spontaneously diabetic BB rats

DEFF Research Database (Denmark)

Heegaard, S

1993-01-01

The morphology of the vitreoretinal border region, also termed the inner limiting membrane, was examined in spontaneously diabetic rats (BB rats), in non-diabetes-prone rats (WB rats) and in Buffalo rats (BUF rats) by scanning electron microscopy (SEM) and transmission electron microscopy (TEM......). This was performed in order to visualize a possible increase in thickness of the lamina densa or in the whole vitreoretinal border region complex with duration of diabetes. The median thickness of the lamina densa in the three groups varied between 34 and 68 nm. In BB rats the thickness decreased with age...... and duration of diabetes. In WB rats the lamina densa thickened up to the 9th month and then decreased to the level of the young rats. In BUF rats the lamina densa decreased in thickness with age. The median thickness of the whole vitreoretinal border region varied between: BB rats: 84 and 126 nm (SEM) and 68...

EST Table: BB986249 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available ar to putative lysosomal glucocerebrosidase [Tribolium castaneum] 10/08/28 low homology 10/08/27 35 %/211 aa... %/206 aa gnl|Amel|GB13722-PA 10/09/10 42 %/206 aa gi|91087345|ref|XP_975608.1| PREDICTED: similar to putative lysosomal glucocerebrosidase [Tribolium castaneum] BB985877 MSV3 ...

EST Table: BB986379 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available ar to putative lysosomal glucocerebrosidase [Tribolium castaneum] 10/08/28 low homology 10/08/27 35 %/211 aa... %/206 aa gnl|Amel|GB13722-PA 10/09/10 43 %/206 aa gi|91087345|ref|XP_975608.1| PREDICTED: similar to putative lysosomal glucocerebrosidase [Tribolium castaneum] BB985877 MSV3 ...

Safety of Bifidobacterium animalis Subsp. Lactis (B. lactis) Strain BB-12-Supplemented Yogurt in Healthy Children.

Science.gov (United States)

Tan, Tina P; Ba, Zhaoyong; Sanders, Mary E; D'Amico, Frank J; Roberts, Robert F; Smith, Keisha H; Merenstein, Daniel J

2017-02-01

Probiotics are live microorganisms that may provide health benefits to the individual when consumed in sufficient quantities. For studies conducted on health or disease endpoints on probiotics in the United States, the Food and Administration has required those studies to be conducted as investigational new drugs. This phase I, double-blinded, randomized, controlled safety study represents the first requirement of this pathway. The purpose of the study was to determine the safety of Bifidobacterium animalis subsp. lactis (B lactis) strain BB-12 (BB-12)-supplemented yogurt when consumed by a generally healthy group of children. The secondary aim was to assess the effect of BB-12-supplemented yogurt on the gut microbiota of the children. Sixty children ages 1 to 5 years were randomly assigned to consume 4 ounces of either BB-12-supplemented yogurt or nonsupplemented control yogurt daily for 10 days. The primary outcome was to assess safety and tolerability, as determined by the number of reported adverse events. A total of 186 nonserious adverse events were reported, with no significant differences between the control and BB-12 groups. No significant changes due to probiotic treatment were observed in the gut microbiota of the study cohort. BB-12-supplemented yogurt is safe and well-tolerated when consumed by healthy children. The present study will form the basis for future randomized clinical trials investigating the potential effects of BB-12-supplemented yogurt in different disease states.

[Creatine kinase BB and lactate in the cerebrospinal fluid of neonates and infants with perinatal injuries of the CNS].

Science.gov (United States)

Alatyrtsev, V V; Iakunin, Iu A; Burkova, A S; Podkopaev, V N; Afonina, L G

1989-01-01

A study was made of the content of creatine kinase-BB (CK-BB) and lactate in cerebrospinal fluid (CSF) of 202 neonates and infants with perinatal CNS injuries. The relationship was found between the rise of the CK-BB content and the gravity of perinatal CNS injuries. The highest content of CK-BB in CSF was marked in neonates with cerebral disorders complicated by infectious and inflammatory diseases (pneumonia, sepsis). Within the first 5 days of life, the children of this group demonstrated the relationship between the content of CK-BB and lactate of CSF. The measurement of the content of CK-BB in CSF should be used for early diagnosis, assessment of the gravity and course of perinatal CNS injuries in neonates and in infants.

Simple and efficient generation of virus-specific T cells for adoptive therapy using anti-4-1BB antibody.

Science.gov (United States)

Imahashi, Nobuhiko; Nishida, Tetsuya; Goto, Tatsunori; Terakura, Seitaro; Watanabe, Keisuke; Hanajiri, Ryo; Sakemura, Reona; Imai, Misa; Kiyoi, Hitoshi; Naoe, Tomoki; Murata, Makoto

2015-01-01

Although recent studies of virus-specific T-cell (VST) therapy for viral infections after allogeneic hematopoietic stem cell transplantation have shown promising results, simple and less time-intensive and labor-intensive methods are required to generate VSTs for the wider application of VST therapy. We investigated the efficacy of anti-CD28 and anti-4-1BB antibodies, which can provide T cells with costimulatory signals similar in strength to those of antigen-presenting cells, in generating VSTs. When peripheral blood mononuclear cells were stimulated with viral peptides together with isotype control, anti-CD28, or anti-4-1BB antibodies, anti-4-1BB antibodies yielded the highest numbers of VSTs, which were on an average 7.9 times higher than those generated with isotype control antibody. The combination of anti-CD28 and anti-4-1BB antibodies did not result in increased numbers of VSTs compared with anti-4-1BB antibody alone. Importantly, the positive effect of anti-4-1BB antibody was observed regardless of the epitopes of the VSTs. In contrast, the capacity of dendritic cells (DCs) to generate VSTs differed considerably depending on the epitopes of the VSTs. Furthermore, the numbers of VSTs generated with DCs were at most similar to those generated with the anti-4-1BB antibody. Generation of VSTs with anti-4-1BB antibody did not result in excessive differentiation or deteriorated function of the generated VSTs compared with those generated with control antibody or DCs. In conclusion, VSTs can be generated rapidly and efficiently by simply stimulating peripheral blood mononuclear cells with viral peptide and anti-4-1BB antibody without using antigen-presenting cells. We propose using anti-4-1BB antibody as a novel strategy to generate VSTs for adoptive therapy.

Radioimmunoassay of serum creatine kinase-BB as a tumour marker in breast cancer

Energy Technology Data Exchange (ETDEWEB)

Thompson, R J; Rubery, E D; Jones, H M [Addenbrooke' s Hospital, Cambridge (UK)

1980-09-27

Brain type creatine kinase-BB (CPK-BB) was measured by radioimmunoassay in the serum of 113 women with breast cancer and 354 female controls. 80% of women with metastatic breast cancer had levels above 3 ng/ml (control range 0.5-3.7 ng/ml); the highest level was 23 ng/ml. 60% of women with local disease but no evidence of distant metastases showed levels above 3 ng/ml, the highest being 9.0 ng/ml. Of women who had presented with stage I, II, or III disease and postoperatively had no evidence of persistent disease 30% had levels above 3 ng/ml. Serial measurements in 31 patients indicated that the serum CPK-BB correlated with clinical response to treatment.

Radioimmunoassay of serum creatine kinase-BB as a tumour marker in breast cancer

International Nuclear Information System (INIS)

Thompson, R.J.; Rubery, E.D.; Jones, H.M.

1980-01-01

Brain type creatine kinase-BB (CPK-BB) was measured by radioimmunoassay in the serum of 113 women with breast cancer and 354 female controls. 80% of women with metastatic breast cancer had levels above 3 ng/ml (control range 0.5-3.7 ng/ml); the highest level was 23 ng/ml. 60% of women with local disease but no evidence of distant metastases showed levels above 3 ng/ml, the highest being 9.0 ng/ml. Of women who had presented with stage I, II, or III disease and postoperatively had no evidence of persistent disease 30% had levels above 3 ng/ml. Serial measurements in 31 patients indicated that the serum CPK-BB correlated with clinical response to treatment. (author)

Clinical usefulness of creatine Kinase BB determination by a Ria method in serum of patients with cerebrovascular accidents

Energy Technology Data Exchange (ETDEWEB)

Nuti, A; Giraldi, C; Piccini, P; Bonucelli, U; Clerico, A; Del Chicca, M G

1988-01-01

The measurement of creatine kinase BB isoenzyme (CK-BB) using RIA methods could have diagnostic utility as a biological marker of cerebral damage. The aim of the present study is to evaluate whether frequent sampling (4 samples/day for 3 days) permits a better correlation between serum CK/sub B/B values and the clinical outcomes of patients with cerebrovascular accidents. 16 in-patients (12 men and 4 women) with stroke (15 of an ischemic nature and 1 hemorrhagic) have benn studied. The presence of stroke was confirmed by clinical symptoms and by CAT results. Blood samples were drawn at 6 and 12 a.m. and at 6 and 12 p.m. over 3 consecutive days after hospitalization. Values of serum CK-BB above the normal range (>7 ng/ml) were found in the 5 of the 16 (31.3%) patients studied. The mean CK-BB value observed in the patients' group was significantly higher than that found in a group of 112 control subjects (controls, mean+-SD=2.1+-1.7 ng/ml vs patients 3.3+-3.4 ng/ml, unpaired t-test p<0.025). We observed a very wide range of serum CKBB levels in most of the patients studied. Some prominent peaks of CK-BB concetrations were found in patients' outcame (Spearman correlation coefficient r-s=0.618, p<0,01). Although our results indicate that the measurement of CK-BB concentrations cannot be considered a sensitive marker of stroke, the significant correlation between serum CK-BB values and outcome suggests that high CK-BB levels could be a sign of worse prognosis in patients with cerebrovascular accidents. 24 refs.

An Evaluation of Taiwanese B&B Service Quality Using the IPA Model

Directory of Open Access Journals (Sweden)

Gao-Liang Wang

2012-09-01

Full Text Available According to a December 2011 report released by Taiwan’s Tourism Bureau, there were 3,763 bed-and-breakfast guesthouses (B&B in Taiwan, 3,367 of which were legal with a combined 13,389 rooms, increasing by 96 percent from December 2006. It seems that the B&B sector is quite a popular target for investors. As the word-of-mouth advertising has been considered one of the most influential marketing methods, those who invest in B&Bs must manage to utilize their limited resources to improve customer satisfaction in a fast-growing and competitive market. The best marketing approach in reaching out to B&B customers, as suggested by this study’s author, would be word-of-mouth adverting. A PZB framed questionnaire is used in this study to explore the expectations and satisfaction of B&B customers both before and after the accommodation period, with the Importance-Performance Analysis (IPA model applied to analyze and measure the service quality. Findings from the questionnaire survey showed 3 out of the totally 23 service factors falling in the “concentrated concerned” quadrant (i.e., tidiness, architectural characteristics, and reasonable rates; 6 factors falling in the “continued maintenance” quadrant (i.e., adequate parking place, commitment to customers, handling of customers’ opinions, legality of B&B, grievance handling, and the local specialties-ordering service; 10 factors falling in the “low priority” quadrant (i.e., modern facilities, safety devices, availability of breakfast, security of online reservations; 4 factors falling in the “over-strived” quadrant (i.e., the availability of custom-made services, the ability to grasp customers’ needs, the availability of tour packages, and the availability of experiences regarding local industries.

Atorvastatin calcium inhibits phenotypic modulation of PDGF-BB-induced VSMCs via down-regulation the Akt signaling pathway.

Science.gov (United States)

Chen, Shuang; Liu, Baoqin; Kong, Dehui; Li, Si; Li, Chao; Wang, Huaqin; Sun, Yingxian

2015-01-01

Plasticity of vascular smooth muscle cells (VSMCs) plays a central role in the onset and progression of proliferative vascular diseases. In adult tissue, VSMCs exist in a physiological contractile-quiescent phenotype, which is defined by lack of the ability of proliferation and migration, while high expression of contractile marker proteins. After injury to the vessel, VSMC shifts from a contractile phenotype to a pathological synthetic phenotype, associated with increased proliferation, migration and matrix secretion. It has been demonstrated that PDGF-BB is a critical mediator of VSMCs phenotypic switch. Atorvastatin calcium, a selective inhibitor of 3-hydroxy-3-methyl-glutaryl l coenzyme A (HMG-CoA) reductase, exhibits various protective effects against VSMCs. In this study, we investigated the effects of atorvastatin calcium on phenotype modulation of PDGF-BB-induced VSMCs and the related intracellular signal transduction pathways. Treatment of VSMCs with atorvastatin calcium showed dose-dependent inhibition of PDGF-BB-induced proliferation. Atorvastatin calcium co-treatment inhibited the phenotype modulation and cytoskeleton rearrangements and improved the expression of contractile phenotype marker proteins such as α-SM actin, SM22α and calponin in comparison with PDGF-BB alone stimulated VSMCs. Although Akt phosphorylation was strongly elicited by PDGF-BB, Akt activation was attenuated when PDGF-BB was co-administrated with atorvastatin calcium. In conclusion, atorvastatin calcium inhibits phenotype modulation of PDGF-BB-induced VSMCs and activation of the Akt signaling pathway, indicating that Akt might play a vital role in the modulation of phenotype.

Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice

OpenAIRE

Almeida-Reis, Rafael; Theodoro-Junior, Osmar A.; Oliveira, Bruno T. M.; Oliva, Leandro V.; Toledo-Arruda, Alessandra C.; Bonturi, Camila R.; Brito, Marlon V.; Lopes, Fernanda D. T. Q. S.; Prado, Carla M.; Florencio, Ariana C.; Martins, Mílton A.; Owen, Caroline A.; Leick, Edna A.; Oliva, Maria L. V.; Tibério, Iolanda F. L. C.

2017-01-01

Background. Proteinases play a key role in emphysema. Bauhinia bauhinioides cruzipain inhibitor (BbCI) is a serine-cysteine proteinase inhibitor. We evaluated BbCI treatment in elastase-induced pulmonary alterations. Methods.??C57BL/6 mice received intratracheal elastase (ELA group) or saline (SAL group). One group of mice was treated with BbCI (days 1, 15, and 21 after elastase instillation, ELABC group). Controls received saline and BbCI (SALBC group). After 28 days, we evaluated respirator...

Insights into physiological traits of Bifidobacterium animalis subsp. lactis BB-12 through membrane proteome analysis

DEFF Research Database (Denmark)

Gilad, Ofir; Hjernø, Karin; Østerlund, Eva Christina

2012-01-01

Bifidobacterium animalis subsp. lactis BB-12 is a widely used probiotic strain associated with a variety of health-promoting traits. There is, however, only limited knowledge available regarding the membrane proteome and the proteins involved in oligosaccharide transport in BB-12. We applied two...

Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat

International Nuclear Information System (INIS)

Rossini, A.A.; Slavin, S.; Woda, B.A.; Geisberg, M.; Like, A.A.; Mordes, J.P.

1984-01-01

Total lymphoid irradiation (TLI) at doses of 2200 rads or greater prevented diabetes in susceptible BB/W rats. Two of 29 (7%) treated rats became diabetic compared with 23 of 39 (59%) controls. TLI did not, however, prevent insulitis or thyroiditis in nondiabetic rats, nor did it restore the depressed concanavalin-A responsiveness of BB rat lymphocytes. T-lymphocyte subset proportions were the same in both groups. TLI was associated with significant radiation-related mortality, and nondiabetic TLI-treated rats weighed significantly less than controls. It was concluded that TLI is effective in the prevention of BB rat diabetes. However, TLI fails to correct the subclinical immunologic abnormalities of the model and is associated with significant morbidity

T cell dysfunction in the diabetes-prone BB rat. A role for thymic migrants that are not T cell precursors

International Nuclear Information System (INIS)

Georgiou, H.M.; Lagarde, A.C.; Bellgrau, D.

1988-01-01

Diabetes-prone BB (BB-DP) rats express several T cell dysfunctions which include poor proliferative and cytotoxic responses to alloantigen. The goal of this study was to determine the origin of these T cell dysfunctions. When BB-DP rats were thymectomized, T cell depleted, and transplanted with neonatal thymus tissue from diabetes-resistant and otherwise normal DA/BB F1 rats, the early restoration of T cell function proceeded normally on a cell-for-cell basis; i.e., peripheral T cells functioned like those from the thymus donor. Because the thymus in these experiments was subjected to gamma irradiation before transplantation and there was no evidence of F1 chimerism in the transplanted BB-DP rats, it appeared that the BB-DP T cell precursors could mature into normally functioning T cells if the maturation process occurred in a normal thymus. If the F1 thymus tissue was treated with dGua before transplantation, the T cells of these animals functioned poorly like those from untreated BB-DP rats. dGua poisons bone marrow-derived cells, including gamma radiation-resistant cells of the macrophage/dendritic cell lineages, while sparing the thymic epithelium. Therefore, the reversal of the T cell dysfunction depends on the presence in the F1 thymus of gamma radiation-resistant, dGua-sensitive F1 cells. Conversely, thymectomized and T cell-depleted F1 rats expressed T cell dysfunction when transplanted with gamma-irradiated BB thymus grafts. T cell responses were normal in animals transplanted with dGua-treated BB thymus grafts. With increasing time after thymus transplantation, T cells from all animals gradually expressed the functional phenotype of the bone marrow donor. Taken together these results suggest that BB-DP bone marrow-derived cells that are not T cell precursors influence the maturation environment in the thymus of otherwise normal BB-DP T cell precursors

Can the use of the Leggett-Garg inequality enhance security of the BB84 protocol?

Science.gov (United States)

Shenoy H., Akshata; Aravinda, S.; Srikanth, R.; Home, Dipankar

2017-08-01

Prima facie, there are good reasons to answer in the negative the question posed in the title: the Bennett-Brassard 1984 (BB84) protocol is provably secure subject to the assumption of trusted devices, while the Leggett-Garg-type inequality (LGI) does not seem to be readily adaptable to the device independent (DI) or semi-DI scenario. Nevertheless, interestingly, here we identify a specific device attack, which has been shown to render the standard BB84 protocol completely insecure, but against which our formulated LGI-assisted BB84 protocol (based on an appropriate form of LGI) is secure.

Measurement Properties of the Smartphone-Based B-B Score in Current Shoulder Pathologies

Directory of Open Access Journals (Sweden)

Claude Pichonnaz

2015-10-01

Full Text Available This study is aimed at the determination of the measurement properties of the shoulder function B-B Score measured with a smartphone. This score measures the symmetry between sides of a power-related metric for two selected movements, with 100% representing perfect symmetry. Twenty healthy participants, 20 patients with rotator cuff conditions, 23 with fractures, 22 with capsulitis, and 23 with shoulder instabilities were measured twice across a six-month interval using the B-B Score and shoulder function questionnaires. The discriminative power, responsiveness, diagnostic power, concurrent validity, minimal detectable change (MDC, minimal clinically important improvement (MCII, and patient acceptable symptom state (PASS were evaluated. Significant differences with the control group and significant baseline—six-month differences were found for the rotator cuff condition, fracture, and capsulitis patient groups. The B-B Score was responsive and demonstrated excellent diagnostic power, except for shoulder instability. The correlations with clinical scores were generally moderate to high, but lower for instability. The MDC was 18.1%, the MCII was 25.2%, and the PASS was 77.6. No floor effect was observed. The B-B Score demonstrated excellent measurement properties in populations with rotator cuff conditions, proximal humerus fractures, and capsulitis, and can thus be used as a routine test to evaluate those patients.

Measurement Properties of the Smartphone-Based B-B Score in Current Shoulder Pathologies

Science.gov (United States)

Pichonnaz, Claude; Duc, Cyntia; Gleeson, Nigel; Ancey, Céline; Jaccard, Hervé; Lécureux, Estelle; Farron, Alain; Jolles, Brigitte M.; Aminian, Kamiar

2015-01-01

This study is aimed at the determination of the measurement properties of the shoulder function B-B Score measured with a smartphone. This score measures the symmetry between sides of a power-related metric for two selected movements, with 100% representing perfect symmetry. Twenty healthy participants, 20 patients with rotator cuff conditions, 23 with fractures, 22 with capsulitis, and 23 with shoulder instabilities were measured twice across a six-month interval using the B-B Score and shoulder function questionnaires. The discriminative power, responsiveness, diagnostic power, concurrent validity, minimal detectable change (MDC), minimal clinically important improvement (MCII), and patient acceptable symptom state (PASS) were evaluated. Significant differences with the control group and significant baseline—six-month differences were found for the rotator cuff condition, fracture, and capsulitis patient groups. The B-B Score was responsive and demonstrated excellent diagnostic power, except for shoulder instability. The correlations with clinical scores were generally moderate to high, but lower for instability. The MDC was 18.1%, the MCII was 25.2%, and the PASS was 77.6. No floor effect was observed. The B-B Score demonstrated excellent measurement properties in populations with rotator cuff conditions, proximal humerus fractures, and capsulitis, and can thus be used as a routine test to evaluate those patients. PMID:26506355

Entropies, Partitionings and Heart Rate Variability

Czech Academy of Sciences Publication Activity Database

Paluš, Milan; Zebrowski, J.

2009-01-01

Roč. 51, č. 2 (2009), s. 65-72 ISSN 0001-7604 Institutional research plan: CEZ:AV0Z10300504 Keywords : coarse-grained entropy rate * HR variability * entropy Subject RIV: BB - Applied Statistics, Operational Research http://www.activitas.org/index.php/nervosa/article/view/25

Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12®-supplemented yogurt in healthy children

Science.gov (United States)

Tan, Tina P.; Ba, Zhaoyong; Sanders, Mary Ellen; D’Amico, Frank J.; Roberts, Robert F.; Smith, Keisha Herbin; Merenstein, Daniel J.

2016-01-01

Objectives Probiotics are live microorganisms that may provide health benefits to the individual when consumed in sufficient quantities. For studies conducted on health or disease endpoints on probiotics in the United States, the Food and Administration (FDA) has required those studies to be conducted as investigational new drugs. This phase I, double-blinded, randomized, controlled safety study represents the first requirement of this pathway. The purpose of the study was to determine the safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12® (BB-12®)-supplemented yogurt when consumed by a generally healthy group of children. The secondary aim was to assess the effect of BB-12®-supplemented yogurt on the gut microbiota of the children. Methods Sixty children aged 1–5 years were randomly assigned to consume four ounces of either BB-12®-supplemented yogurt or non-supplemented control yogurt daily for 10 days. The primary outcome was to assess safety and tolerability, as determined by the number of reported adverse events. Results A total of 186 non-serious adverse events were reported, with no significant differences between the control and BB-12® groups. No significant changes due to probiotic treatment were observed in the gut microbiota of the study cohort. Conclusions BB-12®-supplemented yogurt is safe and well-tolerated when consumed by healthy children. This study will form the basis for future randomized clinical trials investigating the potential effects of BB-12®-supplemented yogurt in different disease states. PMID:28114246

Regulation of a phenylalanine ammonia lyase (BbPAL) by calmodulin in response to environmental changes in the entomopathogenic fungus Beauveria bassiana.

Science.gov (United States)

Kim, Jiyoung; Park, Hyesung; Han, Jae-Gu; Oh, Junsang; Choi, Hyung-Kyoon; Kim, Seong Hwan; Sung, Gi-Ho

2015-11-01

Phenylalanine ammonia lyase (PAL, E.C. 4.3.1.5) catalyses the deamination of L -phenylalanine to trans-cinnamic acid and ammonia, facilitating a critical step in the phenylpropanoid pathway that produces a variety of secondary metabolites. In this study, we isolated BbPAL gene in the entomopathogenic fungus Beauveria bassiana. According to multiple sequence alignment, homology modelling and in vitro PAL activity, we demonstrated that BbPAL acts as a typical PAL enzyme in B. bassiana. BbPAL interacted with calmodulin (CaM) in vitro and in vivo, indicating that BbPAL is a novel CaM-binding protein. The functional role of CaM in BbPAL action was to negatively regulate the BbPAL activity in B. bassiana. High-performance liquid chromatography analysis revealed that L -phenylalanine was reduced and trans-cinnamic acid was increased in response to the CaM inhibitor W-7. Dark conditions suppressed BbPAL activity in B. bassiana, compared with light. In addition, heat and cold stresses inhibited BbPAL activity in B. bassiana. Interestingly, these negative effects of BbPAL activity by dark, heat and cold conditions were recovered by W-7 treatment, suggesting that the inhibitory mechanism is mediated through stimulation of CaM activity. Therefore, this work suggests that BbPAL plays a role in the phenylpropanoid pathway mediated by environmental stimuli via the CaM signalling pathway. © 2015 Society for Applied Microbiology and John Wiley & Sons Ltd.

EST Table: BB987165 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available BB987165 E_ET_MSV3_27C09_F_0 10/09/28 36 %/162 aa ref|NP_001129360.1| osiris 9 [Bom...byx mori] gb|ACI23620.1| osiris 9 [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h FS937505 MSV3 ...

EST Table: BB987373 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available BB987373 E_ET_MSV3_30C12_F_0 10/09/28 39 %/185 aa ref|NP_001129360.1| osiris 9 [Bom...byx mori] gb|ACI23620.1| osiris 9 [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h FS937505 MSV3 ...

EST Table: BB986178 [KAIKOcDNA[Archive

Lifescience Database Archive (English)

Full Text Available BB986178 E_ET_MSV3_14E04_F_0 10/09/28 38 %/173 aa ref|NP_001129360.1| osiris 9 [Bom...byx mori] gb|ACI23620.1| osiris 9 [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h FS937505 MSV3 ...

Confirmation of a predicted lack of IgE binding to Cry3Bb1 from genetically modified (GM) crops.

Science.gov (United States)

Nakajima, Osamu; Koyano, Satoru; Akiyama, Hiroshi; Sawada, Jun-Ichi; Teshima, Reiko

2010-04-01

Some GM crops including MON863 corn and stack varieties contain Cry3Bb1 protein. Cry3Bb1 is very important from the standpoint of assessing the safety of GM crops. In this study Cry3Bb1 was assessed from the standpoint of possible binding to IgE from allergy patients. First, an ELISA that was improved in our laboratory was used to test serum samples from 13 corn allergy patients in the United States with recombinant Cry3Bb1 expressed in Escherichia coli, and serum samples from 55 patients in Japan with various food allergies were also assayed. Two samples from the Japanese allergy patients were suspected of being positive, but Western blotting analysis with purified Cry3Bb1 indicated that the binding between IgE and Cry3Bb1 was nonspecific. Ultimately, no specific binding between IgE and recombinant Cry3Bb1 was detected. Next, all proteins extracted from MON863 corn and non-GM corn were probed with IgE antibodies in serum samples from the corn allergy patients by Western blotting, but the staining patterns of MON863 and non-GM corn were similar, meaning that unintended allergic reactions to MON863 are unlikely to occur. Our study provides additional information that confirms the predicted lack of IgE binding to Cry3Bb1 in people with existing food allergies. Copyright 2009 Elsevier Inc. All rights reserved.

Clinical usefulness of creatine Kinase BB determination by a Ria method in serum of patients with cerebrovascular accidents

International Nuclear Information System (INIS)

Nuti, A.; Giraldi, C.; Piccini, P.; Bonucelli, U.; Clerico, A.; Del Chicca, M. G.

1988-01-01

The measurement of creatine kinase BB isoenzyme (CK-BB) using RIA methods could have diagnostic utility as a biological marker of cerebral damage. The aim of the present study is to evaluate whether frequent sampling (4 samples/day for 3 days) permits a better correlation between serum CK B B values and the clinical outcomes of patients with cerebrovascular accidents. 16 in-patients (12 men and 4 women) with stroke (15 of an ischemic nature and 1 hemorrhagic) have benn studied. The presence of stroke was confirmed by clinical symptoms and by CAT results. Blood samples were drawn at 6 and 12 a.m. and at 6 and 12 p.m. over 3 consecutive days after hospitalization. Values of serum CK-BB above the normal range (>7 ng/ml) were found in the 5 of the 16 (31.3%) patients studied. The mean CK-BB value observed in the patients' group was significantly higher than that found in a group of 112 control subjects (controls, mean+-SD=2.1+-1.7 ng/ml vs patients 3.3+-3.4 ng/ml, unpaired t-test p<0.025). We observed a very wide range of serum CKBB levels in most of the patients studied. Some prominent peaks of CK-BB concetrations were found in patients' outcame (Spearman correlation coefficient r-s=0.618, p<0,01). Although our results indicate that the measurement of CK-BB concentrations cannot be considered a sensitive marker of stroke, the significant correlation between serum CK-BB values and outcome suggests that high CK-BB levels could be a sign of worse prognosis in patients with cerebrovascular accidents

Randomness determines practical security of BB84 quantum key distribution

Science.gov (United States)

Li, Hong-Wei; Yin, Zhen-Qiang; Wang, Shuang; Qian, Yong-Jun; Chen, Wei; Guo, Guang-Can; Han, Zheng-Fu

2015-11-01

Unconditional security of the BB84 quantum key distribution protocol has been proved by exploiting the fundamental laws of quantum mechanics, but the practical quantum key distribution system maybe hacked by considering the imperfect state preparation and measurement respectively. Until now, different attacking schemes have been proposed by utilizing imperfect devices, but the general security analysis model against all of the practical attacking schemes has not been proposed. Here, we demonstrate that the general practical attacking schemes can be divided into the Trojan horse attack, strong randomness attack and weak randomness attack respectively. We prove security of BB84 protocol under randomness attacking models, and these results can be applied to guarantee the security of the practical quantum key distribution system.

Star-planet systems as possible progenitors of cataclysmic binaries

International Nuclear Information System (INIS)

Livio, M.; Soker, N.

1984-01-01

The evolution of a star-planet system is studied, in the phase in which the star becomes a red giant, thus enabling the planet to accrete mass either from its envelope or from its wind. It is found that for planets which are embedded in the envelope, there exists a certain critical initial mass, under which the planets are totally evaporated while spiralling-in. Planets with an initial mass above this critical value are all transformed into low-mass stellar companions to the giant's core. The final masses of these secondaries are almost independent of their initial mass and their initial separation, as long as the latter is greater than a certain critical value. The final masses are essentially determined by the giant's envelope mass. The star-planet separation is found to increase for planets that accrete from the stellar wind, when tidal effects are neglected. Possible consequences of these results on the problem of formation of low-mass cataclysmic binaries are discussed. (author)

Perbandingan Granisetron 0,01 mg/KgBb dengan Ondansetron 0,08 Mg/Kg.Bb Untuk Mencegah Mual Muntah Pascaoperasi Dini Mastektomi Radikal Modifikasi

Directory of Open Access Journals (Sweden)

Budi Fitriyana

2013-04-01

Full Text Available Postoperative nausea and vomiting not only cause discomfort to the patient, but also lead to electrolyte imbalance, regurgitation and aspiration, bleeding and loss of surgical sutures. Patients who experience postoperative nausea and vomiting will require further attention and treatment which of course increases the cost of medical services. Women who underwent mastectomy with accompanying decision underarm lymph nodes have a high risk of postoperative nausea and vomiting. Many anti-vomiting are given including antihistamines, butyrophenon, and dopamine receptor antagonists have been reported to have undesirable side effects including excessive sedation, hypotension, dry mouth, dysphoria, hallucinations and extrapyramidal effects. 5 HT3 receptor antagonists provide a major advancement for treatment of postoperative nausea and vomiting due to fewer side effects when compared with anti-vomiting medications before. This study will compare the two drugs 5 HT3 receptor antagonist granisetron with ondansetron in preventing postoperative nausea and vomiting modified radical mastectomy early. Conducted research on 58 patients ASA I and II modified radical mastectomy is performed under general anesthesia. Sampling was carried out using double-blind randomized controlled trial. Samples were divided into two groups by block randomization. Group G is given granisetron 0.01 gr / kg.bb and group O is given ondansetron 0.08 mg / kg.bb. Drug treatment is administered intravenously 30 minutes before the surgery ended on a complete evaluation of blood pressure, heart rate, oxygen saturation and length of surgery. Postoperative nausea and vomiting shortly after surgery assessed every hour until 6 hours after surgery (early postoperative nausea and vomiting to 4 scale (0-3. Data were analyzed by t-test, Chi-square test, Mann-Whitney test and Fisher's Exact test on Windows SPSS ver.16 The results suggest there is a tendency complaints of postoperative nausea and

bb̅ud̅ four-quark systems in the Born-Oppenheimer approximation: prospects and challenges

Science.gov (United States)

Peters, Antje; Bicudo, Pedro; Wagner, Marc

2018-03-01

We summarize previous work on b̅b̅ud four-quark systems in the Born-Oppenheimer approximation and discuss first steps towards an extension to the theoretically more challenging bb̅ud̅ system. Strategies to identify a possibly existing bb̅ud̅ bound state are discussed and first numerical results are presented.

Expression of platelet-derived growth factor BB, erythropoietin and erythropoietin receptor in canine and feline osteosarcoma.

Science.gov (United States)

Meyer, F R L; Steinborn, R; Grausgruber, H; Wolfesberger, B; Walter, I

2015-10-01

The discovery of expression of the erythropoietin receptor (EPO-R) on neoplastic cells has led to concerns about the safety of treating anaemic cancer patients with EPO. In addition to its endocrine function, the receptor may play a role in tumour progression through an autocrine mechanism. In this study, the expression of EPO, EPO-R and platelet-derived growth factor BB (PDGF-BB) was analysed in five feline and 13 canine osteosarcomas using immunohistochemistry (IHC) and reverse transcription polymerase chain reaction (RT-PCR). EPO expression was positive in all tumours by IHC, but EPO mRNA was only detected in 38% of the canine and 40% of the feline samples. EPO-R was expressed in all samples by quantitative RT-PCR (RT-qPCR) and IHC. EPO-R mRNA was expressed at higher levels in all feline tumours, tumour cell lines, and kidney when compared to canine tissues. PDGF-BB expression was variable by IHC, but mRNA was detected in all samples. To assess the functionality of the EPO-R on tumour cells, the proliferation of canine and feline osteosarcoma cell lines was evaluated after EPO administration using an alamarBlue assay and Ki67 immunostaining. All primary cell lines responded to EPO treatment in at least one of the performed assays, but the effect on proliferation was very low indicating only a weak responsiveness of EPO-R. In conclusion, since EPO and its receptor are expressed by canine and feline osteosarcomas, an autocrine or paracrine tumour progression mechanism cannot be excluded, although in vitro data suggest a minimal role of EPO-R in osteosarcoma cell proliferation. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Energy control centres and traction power management of the OeBB infrastructure; Energieleitstellen und Traktionsstrommanagement der OeBB-Infrastruktur

Energy Technology Data Exchange (ETDEWEB)

Gammer, Michael; Heinze, Florian [OeBB-Infrastruktur AG, Vienna (Austria). Geschaeftsbereich Energie

2013-04-15

According to the OeBB control centre concept, the currently four operations management sites for the 15 kV railway power network will be reduced to just two locations which will be reoriented to operate as energy control centres. For the support of the operators, tools have been developed under the title traction power management, which are based on combined simulations of overhead line network and train operations. (orig.)

Flickering of the symbiotic variable CH Cygni during outburst

Energy Technology Data Exchange (ETDEWEB)

Slovak, M H [Texas Univ., Austin (USA). Dept. of Astronomy; Africano, J

1978-11-01

High-speed and conventional BVRI photometry are reported for the bright symbiotic variable CH Cygni (M6 IIIe), obtained during the course of a recent outburst. Unlike the quiescent symbiotic stars, the presence of flickering similar in nature to that seen in the cataclysmic variables has been confirmed during this active phase. The BVRI photometry for a sample of stars in the field is used to derive the reddening and the distance to CH Cyg. A composite energy distribution is derived from 0.35 to 11.0 ..mu..m which clearly establishes the existence of a variable, blue continuum. The lack of variability in the near infrared suggests that the blue continuum arises from a hot companion. A binary model including a subluminous hot companion accreting material from the stellar wind of an SRa variable is discussed to account for the observed photometric properties.

Air rifles are more than toys: BB gun-related traumatic brain injury.

Science.gov (United States)

Klopotek, Blaine; Weibley, Richard; Chapados, Rene

2014-12-01

Gunshot wounds are traumatic events that emergency departments around the country treat on a daily basis. An increasing number of these wounds are being caused by air rifles that shoot ball bearings (ie, BB guns) and, although uncommon, the results can be fatal. The general public and most practitioners may not realize the damage these "toys" can inflict. This article highlights an unfortunate event involving a BB gun accidentally discharged at close range and the consequences. Data from recent and older studies are discussed regarding the firepower of these guns and their potential for injury. Copyright 2014, SLACK Incorporated.

Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice.

Directory of Open Access Journals (Sweden)

Gloria H Y Lin

2010-06-01

Full Text Available Manipulation of the immune system represents a promising avenue for cancer therapy. Rational advances in immunotherapy of cancer will require an understanding of the precise correlates of protection. Agonistic antibodies against the tumor necrosis factor receptor family member 4-1BB are emerging as a promising tool in cancer therapy, with evidence that these antibodies expand both T cells as well as innate immune cells. Depletion studies have suggested that several cell types can play a role in these immunotherapeutic regimens, but do not reveal which cells must directly receive the 4-1BB signals for effective therapy.We show that re-activated memory T cells are superior to resting memory T cells in control of an 8-day pre-established E.G7 tumor in mice. We find that ex vivo activation of the memory T cells allows the activated effectors to continue to divide and enter the tumor, regardless of antigen-specificity; however, only antigen-specific reactivated memory T cells show any efficacy in tumor control. When agonistic anti-4-1BB antibody is combined with this optimized adoptive T cell therapy, 80% of mice survive and are fully protected from tumor rechallenge. Using 4-1BB-deficient mice and mixed bone marrow chimeras, we find that it is sufficient to have 4-1BB only on the endogenous host alphabeta T cells or only on the transferred T cells for the effects of anti-4-1BB to be realized. Conversely, although multiple immune cell types express 4-1BB and both T cells and APC expand during anti-4-1BB therapy, 4-1BB on cells other than alphabeta T cells is neither necessary nor sufficient for the effect of anti-4-1BB in this adoptive immunotherapy model.This study establishes alphabeta T cells rather than innate immune cells as the critical target in anti-4-1BB therapy of a pre-established tumor. The study also demonstrates that ex vivo activation of memory T cells prior to infusion allows antigen-specific tumor control without the need for

Depressed glucose utilization in lungs of BB wistar spontaneously diabetic rats

International Nuclear Information System (INIS)

Uhal, B.D.; Moxley, M.A.; Longmore, W.J.

1986-01-01

Lungs of BB wistar spontaneously diabetic rats were perfused with [ 14 C(U)]glucose in modified Krebs Ringer bicarbonate medium for 1.5 hours. Lungs from non-diabetic BB Wistar rats were perfused simultaneously and served as controls. The perfusions were terminated by rapid freezing of the tissue in liquid N 2 followed by separation of surfactant and residual lung fractions. The rates of glucose incorporation into surfactant DSPC, PG, and PE were decreased 4.7, 2.4 and 2.5-fold, respectively, in lungs of spontaneously diabetic rats when expressed as final product specific activities. The rate of glucose incorporation into residual PC was also reduced by 2.3-fold. Expressed as moles incorporated per gram wet weight of lung, incorporations into surfactant DSPC, PG and residual PC were also reduced by 4.1, 6.3 and 3.8-fold respectively. These data; (1) agree with previous studies of the lungs of streptozotocin and alloxan-diabetic rats; (2) show that the depressed glucose utilization for lipid synthesis observed previously is not due to streptozotocin or alloxan toxicity; (3) suggest that the BB Wistar rat will provide a useful model for the study of the effects of insulin-dependent diabetes on lung metabolism

Yukawa corrections from PGBs in OGTC model to the process γγ→bb-bar

International Nuclear Information System (INIS)

Huang Jinshu; Song Taiping; Song Haizhen; Lu gongru

2000-01-01

The Yukawa corrections from the pseudo-Goldstone bosons (PGBs) in the one generation technicolor (OGTC) model to the process γγ→bb-bar are calculated. The authors find the corrections from the PGBs to the cross section γγ→bb-bar are more than 10% in the certain parameter values region. The maximum of the relative corrections to the process e + e - →γγ→bb-bar may reach -51% in laser back-scattering photos mode, and is only -17.9% in Beamstrahlung photons mode. The corrections are greatly larger the contributions from the relevant particles in the standard model and the supersymmetric model. It can be considered as a signatures of finding the technicolor at the next-generation high energy photons collision

Multimodal Broadband Vibrational Sum Frequency Generation (MM-BB-V-SFG) Spectrometer and Microscope.

Science.gov (United States)

Lee, Christopher M; Kafle, Kabindra; Huang, Shixin; Kim, Seong H

2016-01-14

A broadband sum frequency generation (BB-SFG) spectrometer with multimodal (MM) capabilities was constructed, which could be routinely reconfigured for tabletop experiments in reflection, transmission, and total internal reflection (TIR) geometries, as well as microscopic imaging. The system was constructed using a Ti:sapphire amplifier (800 nm, pulse width = 85 fs, repetition rate = 2 kHz), an optical parameter amplification (OPA) system for production of broadband IR pulses tunable between 1000 and 4000 cm(-1), and two Fabry-Pérot etalons arranged in series for production of narrowband 800 nm pulses. The key feature allowing the MM operation was the nearly collinear alignment of the visible (fixed, 800 nm) and infrared (tunable, 1000-4000 cm(-1)) pulses which were spatially separated. Physical insights discussed in this paper include the comparison of spectral bandwidth produced with 40 and 85 fs pump beams, the improvement of spectral resolution using etalons, the SFG probe volume in bulk analysis, the normalization of SFG signals, the stitching of multiple spectral segments, and the operation in different modes for air/liquid and adsorbate/solid interfaces, bulk samples, as well as spectral imaging combined with principle component analysis (PCA). The SFG spectral features obtained with the MM-BB-SFG system were compared with those obtained with picosecond-scanning-SFG system and high-resolution BB-SFG system (HR-BB-SFG) for dimethyl sulfoxide, α-pinene, and various samples containing cellulose (purified commercial products, Cladophora cell wall, cotton and flax fibers, and onion epidermis cell wall).

Variation of Surface Air Temperature in Relation to El Nino and Cataclysmic Volcanic Eruptions, 1796-1882

Science.gov (United States)

Wilson, Robert M.

1999-01-01

During the contemporaneous interval of 1796-1882 a number of significant decreases in temperature are found in the records of Central England and Northern Ireland. These decreases appear to be related to the occurrences of El Nino and/or cataclysmic volcanic eruptions. For example, a composite of residual temperatures of the Central England dataset, centering temperatures on the yearly onsets of 20 El Nino of moderate to stronger strength, shows that, on average, the change in temperature varied by about +/- 0.3 C from normal being warmer during the boreal fall-winter leading up to the El Nino year and cooler during the spring-summer of the El Nino year. Also, the influence of El Nino on Central England temperatures appears to last about 1-2 years. Similarly, a composite of residual temperatures of the Central England dataset, centering temperatures on the month of eruption for 26 cataclysmic volcanic eruptions, shows that, on average, the change in temperature decreased by about 0.1 - 0.2 C, typically, 1-2 years after the eruption, although for specific events, like Tambora, the decrease was considerably greater. Additionally, tropical eruptions appear to produce greater changes in temperature than extratropical eruptions, and eruptions occurring in boreal spring-summer appear to produce greater changes in temperature than those occurring in fall-winter.

Dual-signal amplification strategy for ultrasensitive chemiluminescence detection of PDGF-BB in capillary electrophoresis.

Science.gov (United States)

Cao, Jun-Tao; Wang, Hui; Ren, Shu-Wei; Chen, Yong-Hong; Liu, Yan-Ming

2015-12-01

Many efforts have been made toward the achievement of high sensitivity in capillary electrophoresis coupled with chemiluminescence detection (CE-CL). This work describes a novel dual-signal amplification strategy for highly specific and ultrasensitive CL detection of human platelet-derived growth factor-BB (PDGF-BB) using both aptamer and horseradish peroxidase (HRP) modified gold nanoparticles (HRP-AuNPs-aptamer) as nanoprobes in CE. Both AuNPs and HRP in the nanoprobes could amplify the CL signals in the luminol-H2 O2 CL system, owing to the excellent catalytic behavior of AuNPs and HRP in the CL system. Meanwhile, the high affinity of aptamer modified on the AuNPs allows detection with high specificity. As proof-of-concept, the proposed method was employed to quantify the concentration of PDGF-BB from 0.50 to 250 fm with a detection limit of 0.21 fm. The applicability of the assay was further demonstrated in the analysis of PDGF-BB in human serum samples with acceptable accuracy and reliability. The result of this study exhibits distinct advantages, such as high sensitivity, good specificity, simplicity, and very small sample consumption. The good performances of the proposed strategy provide a powerful avenue for ultrasensitive detection of rare proteins in biological sample, showing great promise in biochemical analysis. Copyright © 2015 John Wiley & Sons, Ltd.

First observation of forward Z→bb¯ production in pp collisions at s=8 TeV

Directory of Open Access Journals (Sweden)

R. Aaij

2018-01-01

Full Text Available The decay Z→bb¯ is reconstructed in pp collision data, corresponding to 2 fb−1 of integrated luminosity, collected by the LHCb experiment at a centre-of-mass energy of s=8 TeV. The product of the Z production cross-section and the Z→bb¯ branching fraction is measured for candidates in the fiducial region defined by two particle-level b-quark jets with pseudorapidities in the range 2.220 GeV and dijet invariant mass in the range 45bb¯ events, where the uncertainty is statistical, a production cross-section times branching fraction of 332±46±59 pb is obtained, where the first uncertainty is statistical and the second systematic. The measured significance of the signal yield is 6.0 standard deviations. This measurement represents the first observation of the Z→bb¯ production in the forward region of pp collisions.

Fourth-generation effects in Z0 to bb-bar decay

International Nuclear Information System (INIS)

Ma Wengan; Xu Zizong

1991-01-01

Possible fourth generation effects in partial widths in Z 0 into bb-bar decay are discussed with the consideration of all quark mixing within the minimal standard model. We show that it is possible to disentangle the effects from the fourth generation. (author)

Decoy-state BB84 protocol using space division multiplexing in silicon photonics

DEFF Research Database (Denmark)

Bacco, Davide; Ding, Yunhong; Dalgaard, Kjeld

2017-01-01

Quantum key distribution (QKD), a technique based on quantum physics, provides unconditional secure quantum keys to be shared between two or more clients (Alice and Bob) [1]. Most QKD systems are implemented in a point-to-point link using bulky and expensive devices. Consequently a large scale...... experiments have already demonstrated conventional binary QKD systems, using polarization and phase reference degrees of freedom [2, 3]. In this paper, we show the first silicon chip-to-chip decoy-state BB84 protocol based on spatial degrees of freedom (the cores of a multi-core fiber-MCF-). By tuning...... the superposition of the quantum state between cores, combined with a positive/negative phase relation. A train of weak coherent pulses (5 kHz repetition and 10 ns wide) are injected into the transmitter chip (Alice), where multiple variable optical attenuators (VOAs) are used to decrease the number of photons per...

White dwarfs in cataclysmic variables

International Nuclear Information System (INIS)

Sion, E.M.

1987-01-01

The physical properties and evolutionary state of the underlying white dwarfs in CVs are explored. Observations of 25 white dwarfs with effective temperature upper limits of 9000-75,000 K are discussed. Correlations between effective temperature, orbital period, accretion rate, and CV type with respect to the CV period gap are considered. Quasi-static and hydrodynamic evolutionary models are used to explain the surface temperature/luminosity distribution ratios. 42 references

Towards the first B[B0(s) → μ+μ-] measurements with the LHCb detector

International Nuclear Information System (INIS)

Adrover Pacheco, C.

2012-01-01

The rare decays B 0 s → μ + μ - are benchmark channels to constrain models beyond the Standard Model (BSM) with a larger Higgs sector. In the SM, the branching fraction of these decays is predicted with a good accuracy: B(B 0 s → μ + μ - )=(3.2±0.2)*10 -9 and B(B 0 → μ + μ - )=(0.10±0.01)*10 -10 . Any deviation from these values can lead to indications of physics BSM. The core of this thesis comprises two main topics: the background rejection and the signal yields extraction. We have optimized a multivariate classifier based on the boosted decision trees technique allowing for a drastic reduction of the B→h + h' - (h=p,K) background. After the selection process, about 76% of the combinatorial background for B 0 s → μ + μ - is removed, while keeping a signal efficiency of about 92%. A further discrimination between signal and background is accomplished with another multivariate classifier optimized to have a large background rejection in the low signal efficiency region. The work presented in this thesis describes the optimization of a boosted decision trees classifier that suppresses 99.9% of the background, after the afore-mentioned selection process, for a signal efficiency of 50%. We have proposed a method to estimate the signal yields present in our data sample using an extended maximum likelihood fit. The validation of the fit using simulation reflects the proper estimation of the statistical uncertainties, and systematic uncertainties have been carefully studied and taken into account in the final results for the 2011 1 fb -1 data sample: B(B 0 s → μ + μ - )=(1.4(+1.6-1.1)(stat)(+0.5-0.8)(syst))*10 -9 and B(B 0 → μ + μ - )=(0.3(+0.5-0.4)(stat)(+0.4-0.3)(syst))*10 -9 . Given the lack of signal evidence, upper limits on the branching fractions are computed: B(B 0 s → μ + μ - ) -9 and B(B 0 → μ + μ - ) -10 , which are the most restrictive limits up to date. (author)

Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent

Directory of Open Access Journals (Sweden)

Diogo Gomes-Silva

2017-10-01

Full Text Available Antigen-independent tonic signaling by chimeric antigen receptors (CARs can increase differentiation and exhaustion of T cells, limiting their potency. Incorporating 4-1BB costimulation in CARs may enable T cells to resist this functional exhaustion; however, the potential ramifications of tonic 4-1BB signaling in CAR T cells remain unclear. Here, we found that tonic CAR-derived 4-1BB signaling can produce toxicity in T cells via continuous TRAF2-dependent activation of the nuclear factor κB (NF-κB pathway and augmented FAS-dependent cell death. This mechanism was amplified in a non-self-inactivating gammaretroviral vector through positive feedback on the long terminal repeat (LTR promoter, further enhancing CAR expression and tonic signaling. Attenuating CAR expression by substitution with a self-inactivating lentiviral vector minimized tonic signaling and improved T cell expansion and anti-tumor function. These studies illuminate the interaction between tonic CAR signaling and the chosen expression platform and identify inhibitory properties of the 4-1BB costimulatory domain that have direct implications for rational CAR design.

Crystallization and preliminary X-ray crystallographic study of the extracellular domain of the 4-1BB ligand, a member of the TNF family

Energy Technology Data Exchange (ETDEWEB)

Byun, Jung-Sue; Kim, Dong-Uk [Department of Biology, Yonsei University, Seoul 120-749 (Korea, Republic of); Ahn, Byungchan; Kwon, Byoung Se [Immunomodulation Research Center, Ulsan University, Ulsan 680-749 (Korea, Republic of); Cho, Hyun-Soo, E-mail: hscho8@yonsei.ac.kr [Department of Biology, Yonsei University, Seoul 120-749 (Korea, Republic of)

2006-01-01

The extracellular domain of the 4-1BB ligand fused with glutathione-S-transferase was expressed in Escherichia coli (Origami) and purified by using affinity and ion-exchange column chromatographic methods. Crystals of the 4-1BB ligand were obtained at 290 K by the hanging-drop vapour-diffusion method. The 4-1BB ligand, a member of the tumour necrosis factor (TNF) family, is an important co-stimulatory molecule that plays a key role in the clonal expansion and survival of CD8+ T cells. Signalling through binding of the 4-1BB ligand and 4-1BB has been reported to enhance CD8+ T-cell expansion and protect activated CD8+ T cells from death. The 4-1BB ligand is an integral protein expressed on activated antigen-presenting cells. The extracellular domain of the 4-1BB ligand fused with glutathione-S-transferase was expressed in Escherichia coli (Origami) and purified by using affinity and ion-exchange column chromatographic methods. Crystals of the 4-1BB ligand were obtained at 290 K by the hanging-drop vapour-diffusion method. X-ray diffraction data were collected from these crystals to 2.8 Å resolution and the crystals belong to space group C2, with unit-cell parameters a = 114.6, b = 73.8, c = 118.50 Å, β = 115.5°.

Crystallization and preliminary X-ray crystallographic study of the extracellular domain of the 4-1BB ligand, a member of the TNF family

International Nuclear Information System (INIS)

Byun, Jung-Sue; Kim, Dong-Uk; Ahn, Byungchan; Kwon, Byoung Se; Cho, Hyun-Soo

2005-01-01

The extracellular domain of the 4-1BB ligand fused with glutathione-S-transferase was expressed in Escherichia coli (Origami) and purified by using affinity and ion-exchange column chromatographic methods. Crystals of the 4-1BB ligand were obtained at 290 K by the hanging-drop vapour-diffusion method. The 4-1BB ligand, a member of the tumour necrosis factor (TNF) family, is an important co-stimulatory molecule that plays a key role in the clonal expansion and survival of CD8+ T cells. Signalling through binding of the 4-1BB ligand and 4-1BB has been reported to enhance CD8+ T-cell expansion and protect activated CD8+ T cells from death. The 4-1BB ligand is an integral protein expressed on activated antigen-presenting cells. The extracellular domain of the 4-1BB ligand fused with glutathione-S-transferase was expressed in Escherichia coli (Origami) and purified by using affinity and ion-exchange column chromatographic methods. Crystals of the 4-1BB ligand were obtained at 290 K by the hanging-drop vapour-diffusion method. X-ray diffraction data were collected from these crystals to 2.8 Å resolution and the crystals belong to space group C2, with unit-cell parameters a = 114.6, b = 73.8, c = 118.50 Å, β = 115.5°

DELPHI results on the Z0 → bb-bar partial width and on the average B hadrons semileptonic branching ratio

International Nuclear Information System (INIS)

Bambade, P.

1992-05-01

Results from DELPHI on the Z 0 → bb-bar partial width (Γ ( bb-bar)) and on the average B hadron semileptonic branching ratio (B s.l. ) are reviewed. Prospects are given for improving these measurements, using different complementary techniques. A new and potentially powerful method for extracting the branching ratio R b with minimal errors is suggested, based on using the redundancy provided by two independent discriminators for bb-bar events. (R.P.) 12 refs., 3 figs

REFIR/BB initial observations in the water vapour rotational band: Results from a field campaign

International Nuclear Information System (INIS)

Esposito, F.; Grieco, G.; Leone, L.; Restieri, R.; Serio, C.; Bianchini, G.; Palchetti, L.; Pellegrini, M.; Cuomo, V.; Masiello, G.; Pavese, G.

2007-01-01

There is a growing interest in the far infrared spectral region 17-50 μm as a remote sensing tool in atmospheric sciences, since this portion of the spectrum contains the characteristic molecular rotational band for water vapour. Much of the Earth energy lost to space is radiated through this spectral region. The Radiation Explorer in the Far InfraRed Breadboard (REFIR/BB) spectrometer was born because of the quest to make observations in the far infrared. REFIR/BB is a Fourier Transform Spectrometer with a sampling resolution of 0.5 cm -1 and it was tested for the first time in the field to check its reliability and radiometric performance. The field campaign was held at Toppo di Castelgrande (40 o 49' N, 15 o 27' E, 1258 m a. s. l.), a mountain site in South Italy. The spectral and radiometric performance of the instrument and initial observations are shown in this paper. Comparisons to both (1) BOMEM MR100 Fourier Transform spectrometer observations and (2) line-by-line radiative transfer calculations for selected clear sky are presented and discussed. These comparisons (1) show a very nice agreement between radiance measured by REFIR/BB and by BOMEM MR100 and (2) demonstrate that REFIR/BB accurately observes the very fine spectral structure in the water vapour rotational band

Effect of platelet-derived growth factor-BB on bone formation in calvarial defects: an experimental study in rabbits

DEFF Research Database (Denmark)

Vikjaer, D; Blom, S; Hjørting-Hansen, E

1997-01-01

The effect of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) on bone healing was examined in calvarial defects in rabbits. Bicortical circular (critical size) defects were prepared in the calvarial bone of 16 rabbits. The defects were closed on the dural side and covered externally...

Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways

Energy Technology Data Exchange (ETDEWEB)

Chan, Chi-Ming [School of Medicine, Fu Jen Catholic University, Taipei Hsien, Taiwan, ROC (China); Department of Ophthalmology, Cardinal Tien Hospital, Taipei Hsien, Taiwan, ROC (China); Fang, Jia-You [Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan, ROC (China); Lin, Hsin-Huang [School of Medicine, Fu Jen Catholic University, Taipei Hsien, Taiwan, ROC (China); Yang, Chi-Yea [Department of Biotechnology, Vanung University, Taoyuan, Taiwan, ROC (China); Hung, Chi-Feng, E-mail: 054317@mail.fju.edu.tw [School of Medicine, Fu Jen Catholic University, Taipei Hsien, Taiwan, ROC (China)

2009-10-09

Retinal pigment epithelial (RPE) cells play a dominant role in the development of proliferative vitreoretinopathy (PVR), which is the leading cause of failure in retinal reattachment surgery. Several studies have shown that platelet-derived growth factor (PDGF) exhibits chemotaxis and proliferation effects on RPE cells in PVR. In this study, the inhibitory effect of lycopene on PDGF-BB-induced ARPE19 cell migration is examined. In electric cell-substrate impedance sensing (ECIS) and Transwell migration assays, significant suppression of PDGF-BB-induced ARPE19 cell migration by lycopene is observed. Cell viability assays show no cytotoxicity of lycopene on RPE cells. Lycopene shows no effect on ARPE19 cell adhesion and is found to inhibit PDGF-BB-induced tyrosine phosphorylation and the underlying signaling pathways of PI3K, Akt, ERK and p38 activation. However, PDGF-BB and lycopene show no effects on JNK activation. Taken together, our results demonstrate that lycopene inhibits PDGF-BB-induced ARPE19 cell migration through inhibition of PI3K/Akt, ERK and p38 activation.

Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways

International Nuclear Information System (INIS)

Chan, Chi-Ming; Fang, Jia-You; Lin, Hsin-Huang; Yang, Chi-Yea; Hung, Chi-Feng

2009-01-01

Retinal pigment epithelial (RPE) cells play a dominant role in the development of proliferative vitreoretinopathy (PVR), which is the leading cause of failure in retinal reattachment surgery. Several studies have shown that platelet-derived growth factor (PDGF) exhibits chemotaxis and proliferation effects on RPE cells in PVR. In this study, the inhibitory effect of lycopene on PDGF-BB-induced ARPE19 cell migration is examined. In electric cell-substrate impedance sensing (ECIS) and Transwell migration assays, significant suppression of PDGF-BB-induced ARPE19 cell migration by lycopene is observed. Cell viability assays show no cytotoxicity of lycopene on RPE cells. Lycopene shows no effect on ARPE19 cell adhesion and is found to inhibit PDGF-BB-induced tyrosine phosphorylation and the underlying signaling pathways of PI3K, Akt, ERK and p38 activation. However, PDGF-BB and lycopene show no effects on JNK activation. Taken together, our results demonstrate that lycopene inhibits PDGF-BB-induced ARPE19 cell migration through inhibition of PI3K/Akt, ERK and p38 activation.

The ability of the biological control agent Bacillus subtilis, strain BB, to colonise vegetable brassicas endophytically following seed inoculation

NARCIS (Netherlands)

Wulff, E.G.; Vuurde, van J.W.L.; Hockenhull, J.

2003-01-01

The ability of Bacillus subtilis, strain BB, to colonise cabbage seedlings endophytically was examined following seed inoculation. Strain BB was recovered from different plant parts including leaves (cotyledons), stem (hypocotyl) and roots. While high bacterial populations persisted in the roots and

Z → bb-bar probability and asymmetry in a model of dynamical electroweak symmetry breaking

International Nuclear Information System (INIS)

Arbuzov, B.A.; Osipov, M.Yu.

1997-01-01

The deviations from the standard model in the probability of Z → bb-bar decay and in the forward-backward asymmetry in the reaction e + e - → bb-bar are studied in the framework of the model of dynamical electroweak symmetry breaking, the basic point of which is the existence of a triple anomalous W-boson vertex in a region of momenta restricted by a cutoff. A set of equations for additional terms in the W b t-bar vertex is obtained and its solution to the process Z → bb-bar is applied. It is shown that it is possible to obtain a consistent description of both deviations, which is quite nontrivial because these effects are not simply correlated. The necessary value of the anomalous W interaction coupling, λ = -0.22 ± 0.01, is consistent with existing limitations and leads to definite predictions, e.g., for pair W production in e + e - collisions at LEP 200

The Transcription Factor DAF-16 is Essential for Increased Longevity in C. elegans Exposed to Bifidobacterium longum BB68.

Science.gov (United States)

Zhao, Liang; Zhao, Yang; Liu, Ruihai; Zheng, Xiaonan; Zhang, Min; Guo, Huiyuan; Zhang, Hao; Ren, Fazheng

2017-08-07

The longevity-promoting benefits of lactobacilli were hypothesized as early as 1907. Although the anti-aging effects of lactic acid bacteria (LAB) have been observed in nematodes, rodents and humans for over a century, the mechanisms underlying the effects of probiotics on aging have rarely been assessed. Using the Caenorhabditis elegans (C. elegans) model, various studies have elucidated the role of different signaling cascades, especially the DAF-16 cascade, on lifespan extension by LAB. In this study, the mechanisms through which Bifidobacterium longum strain BB68 affects the longevity of C. elegans were assessed. The lifespan of nematodes increased by 28% after worms were fed BB68, and this extension of lifespan was completely lost in backgrounds containing a mutated DAF-16 gene. High levels of DAF-16 (in the daf-16 (mu86); muIs61 strain) nuclear accumulation and high expression of the SOD-3 gene (a DAF-16-specific target gene) were observed as a result of BB68 treatment. Immunofluorescence microscopy revealed that TIR-1 and JNK-1 are involved in the phosphorylation and activation of DAF-16. Thus, BB68 increased the longevity of nematodes by activating the TIR-1 - JNK-1 - DAF-16 signaling pathway, and the cell wall component of BB68 contributed to longevity.

Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy adults on antibiotics: a phase I safety study.

Science.gov (United States)

Merenstein, Daniel J; Tan, Tina P; Molokin, Aleksey; Smith, Keisha Herbin; Roberts, Robert F; Shara, Nawar M; Mete, Mihriye; Sanders, Mary Ellen; Solano-Aguilar, Gloria

2015-01-01

Probiotics are live microorganisms that, when administered in sufficient doses, provide health benefits on the host. The United States Food and Drug Administration (FDA) requires phase I safety studies for probiotics when the intended use of the product is as a drug. The purpose of the study was to determine the safety of Bifidobacterium animalis subsp lactis (B. lactis) strain BB-12 (BB-12)-supplemented yogurt when consumed by a generally healthy group of adults who were prescribed a 10-day course of antibiotics for a respiratory infection. Secondary aims were to assess the ability of BB-12 to affect the expression of whole blood immune markers associated with cell activation and inflammatory response. A phase I, double-blinded, randomized controlled study was conducted in compliance with FDA guidelines for an Investigational New Drug (IND). Forty participants were randomly assigned to consume 4 ounces of either BB-12 -supplemented yogurt or non-supplemented control yogurt daily for 10 d. The primary outcome was to assess safety and tolerability, assessed by the number of reported adverse events. A total of 165 non-serious adverse events were reported, with no differences between the control and BB-12 groups. When compared to the control group, B lactis fecal levels were modestly higher in the BB-12-supplemented group. In a small subset of patients, changes in whole blood expression of genes associated with regulation and activation of immune cells were detected in the BB-12-supplemented group. BB-12-supplemented yogurt is safe and well tolerated when consumed by healthy adults concurrently taking antibiotics. This study will form the basis for future randomized clinical trials investigating the potential immunomodulatory effects of BB-12-supplemented yogurt in a variety of disease states.

De Novo whole genome sequence of Xylella fastidiosa subsp. multiplex strain BB01 from blueberry in Georgia, USA

Science.gov (United States)

This study reports a de novo assembled draft genome sequence of Xylella fastidiosa subsp. multiplex strain BB01 causing blueberry bacterial leaf scorch in Georgia, USA. The BB01 genome is 2,517,579 bp with a G+C content of 51.8% and 2,943 open reading frames (ORFs) and 48 RNA genes....

76 FR 61129 - BB Liquidation Inc., Order of Suspension of Trading

Science.gov (United States)

2011-10-03

... current and accurate information concerning the securities of BB Liquidation Inc. because of assertions in third-party press releases to investors concerning, among other things, the company's current financial... protection of investors require a suspension of trading in the securities of the company listed above...

Iptakalim inhibits PDGF-BB-induced human airway smooth muscle cells proliferation and migration

Energy Technology Data Exchange (ETDEWEB)

Liu, Wenrui; Kong, Hui; Zeng, Xiaoning; Wang, Jingjing; Wang, Zailiang; Yan, Xiaopei; Wang, Yanli; Xie, Weiping, E-mail: wpxie@njmu.edu.cn; Wang, Hong, E-mail: hongwang@njmu.edu.cn

2015-08-15

Chronic airway diseases are characterized by airway remodeling which is attributed partly to the proliferation and migration of airway smooth muscle cells (ASMCs). ATP-sensitive potassium (K{sub ATP}) channels have been identified in ASMCs. Mount evidence has suggested that K{sub ATP} channel openers can reduce airway hyperresponsiveness and alleviate airway remodeling. Opening K{sup +} channels triggers K{sup +} efflux, which leading to membrane hyperpolarization, preventing Ca{sup 2+}entry through closing voltage-operated Ca{sup 2+} channels. Intracellular Ca{sup 2+} is the most important regulator of muscle contraction, cell proliferation and migration. K{sup +} efflux decreases Ca{sup 2+} influx, which consequently influences ASMCs proliferation and migration. As a K{sub ATP} channel opener, iptakalim (Ipt) has been reported to restrain the proliferation of pulmonary arterial smooth muscle cells (PASMCs) involved in vascular remodeling, while little is known about its impact on ASMCs. The present study was designed to investigate the effects of Ipt on human ASMCs and the mechanisms underlying. Results obtained from cell counting kit-8 (CCK-8), flow cytometry and 5-ethynyl-2′-deoxyuridine (EdU) incorporation showed that Ipt significantly inhibited platelet-derived growth factor (PDGF)-BB-induced ASMCs proliferation. ASMCs migration induced by PDGF-BB was also suppressed by Ipt in transwell migration and scratch assay. Besides, the phosphorylation of Ca{sup 2+}/calmodulin-dependent kinase II (CaMKII), extracellular regulated protein kinases 1/2 (ERK1/2), protein kinase B (Akt), and cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) were as well alleviated by Ipt administration. Furthermore, we found that the inhibition of Ipt on the PDGF-BB-induced proliferation and migration in human ASMCs was blocked by glibenclamide (Gli), a selective K{sub ATP} channel antagonist. These findings provide a strong evidence to support that Ipt

Identification of two Th1 cell epitopes on the Babesia bovis-encoded 77-kilodalton merozoite protein (Bb-1) by use of truncated recombinant fusion proteins.

Science.gov (United States)

Brown, W C; Zhao, S; Woods, V M; Tripp, C A; Tetzlaff, C L; Heussler, V T; Dobbelaere, D A; Rice-Ficht, A C

1993-01-01

Previous studies have demonstrated the serologic and T-cell immunogenicity for cattle of a recombinant form of the apical complex-associated 77-kDa merozite protein of Babesia bovis, designated Bb-1. The present study characterizes the immunogenic epitopes of the Bb-1 protein. A series of recombinant truncated fusion proteins spanning the majority of the Bb-1 protein were expressed in Escherichia coli, and their reactivities with bovine peripheral blood mononuclear cells and T-cell clones derived from B. bovis-immune cattle and with rabbit antibodies were determined. Lymphocytes from two immune cattle were preferentially stimulated by the N-terminal half of the Bb-1 protein (amino acids 23 to 266, termed Bb-1A), localizing the T-cell epitopes to the Bb-1A portion of the molecule. CD4+ T-cell clones derived by stimulation with the intact Bb-1 fusion protein were used to identify two T-cell epitopes in the Bb-1A protein, consisting of amino acids SVVLLSAFSGN VWANEAEVSQVVK and FSDVDKTKSTEKT (residues 23 to 46 and 82 to 94). In contrast, rabbit antiserum raised against the intact fusion protein reacted only with the C-terminal half of the protein (amino acids 267 to 499, termed Bb-1B), which contained 28 tandem repeats of the tetrapeptide PAEK or PAET. Biological assays and Northern (RNA) blot analyses for cytokines revealed that following activation with concanavalin A, T-cell clones reactive against the two Bb-1A epitopes produced interleukin-2, gamma interferon, and tumor necrosis factors beta and alpha, but not interleukin-4, suggesting that the Bb-1 antigen preferentially stimulates the Th1 subset of CD4+ T cells in cattle. The studies described here report for the first time the characterization, by cytokine production, of the Th1 subset of bovine T cells and show that, as in mice, protozoal antigens can induce Th1 cells in ruminants. This first demonstration of B. bovis-encoded Th1 cell epitopes provides a rationale for incorporation of all or part of the Bb-1

Platelet-derived growth factor (PDGF-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation

Directory of Open Access Journals (Sweden)

Bethel-Brown Crystal

2012-12-01

Full Text Available Abstract Chemokine (C-C motif ligand 2, also known as monocyte chemoattractant protein 1 (MCP-1 is an important factor for the pathogenesis of HIV-associated neurocognitive disorders (HAND. The mechanisms of MCP-1-mediated neuropathogenesis, in part, revolve around its neuroinflammatory role and the recruitment of monocytes into the central nervous system (CNS via the disrupted blood-brain barrier (BBB. We have previously demonstrated that HIV-1/HIV-1 Tat upregulate platelet-derived growth factor (PDGF-BB, a known cerebrovascular permeant; subsequently, the present study was aimed at exploring the regulation of MCP-1 by PDGF-BB in astrocytes with implications in HAND. Specifically, the data herein demonstrate that exposure of human astrocytes to HIV-1 LAI elevated PDGF-B and MCP-1 levels. Furthermore, treating astrocytes with the human recombinant PDGF-BB protein significantly increased the production and release of MCP-1 at both the RNA and protein levels. MCP-1 induction was regulated by activation of extracellular-signal-regulated kinase (ERK1/2, c-Jun N-terminal kinase (JNK and p38 mitogen-activated protein (MAP kinases and phosphatidylinositol 3-kinase (PI3K/Akt pathways and the downstream transcription factor, nuclear factor κB (NFκB. Chromatin immunoprecipitation (ChIP assays demonstrated increased binding of NFκB to the human MCP-1 promoter following PDGF-BB exposure. Conditioned media from PDGF-BB-treated astrocytes increased monocyte transmigration through human brain microvascular endothelial cells (HBMECs, an effect that was blocked by STI-571, a tyrosine kinase inhibitor (PDGF receptor (PDGF-R blocker. PDGF-BB-mediated release of MCP-1 was critical for increased permeability in an in vitro BBB model as evidenced by blocking antibody assays. Since MCP-1 is linked to disease severity, understanding its modulation by PDGF-BB could aid in understanding the proinflammatory responses in HAND. These results suggest that astrocyte

Silicon photonic transceiver circuit for high-speed polarization-based discrete variable quantum key distribution.

Science.gov (United States)

Cai, Hong; Long, Christopher M; DeRose, Christopher T; Boynton, Nicholas; Urayama, Junji; Camacho, Ryan; Pomerene, Andrew; Starbuck, Andrew L; Trotter, Douglas C; Davids, Paul S; Lentine, Anthony L

2017-05-29

We demonstrate a silicon photonic transceiver circuit for high-speed discrete variable quantum key distribution that employs a common structure for transmit and receive functions. The device is intended for use in polarization-based quantum cryptographic protocols, such as BB84. Our characterization indicates that the circuit can generate the four BB84 states (TE/TM/45°/135° linear polarizations) with >30 dB polarization extinction ratios and gigabit per second modulation speed, and is capable of decoding any polarization bases differing by 90° with high extinction ratios.

Improved Cytotoxic T Lymphocyte Responses to Vaccination with Porcine Reproductive and Respiratory Syndrome Virus in 4-1BB Transgenic Pigs

Directory of Open Access Journals (Sweden)

Guangping Huang

2017-12-01

Full Text Available Vaccination is the most reliable measure to prevent infectious diseases in domestic animals. Development of novel vaccines demands extensive studies with new technologies, such as using novel adjuvants and immunomodulatory molecules. The co-stimulatory molecule 4-1BB provides a key signal that directs the fate of T cells during activation, and thus is important to their function in immune protection. To determine whether host immune responses to viral infection could be promoted by enhancing 4-1BB co-stimulation, in this study, we produced transgenic pig clones expressing an extra copy of the 4-1BB gene by clustered regularly interspaced short palindromic repeats/CRISPR-associated gene 9-mediated homologous recombination at the Rosa26 locus. The immune responses of transgenic pigs to porcine reproductive and respiratory syndrome virus (PRRSV vaccine were determined on day 14. We show that peripheral blood lymphocytes of transgenic pigs expressed around twice the level of 4-1BB mRNA than those of control pigs. We also found IL-2, TNF-α, and granzyme B mRNA levels as well as PRRSV-specific IFN-γ response were significantly upregulated in 4-1BB transgenic pigs, leading to more efficient cytotoxic T lymphocyte (CTL killing, whereas the expressions of IL-4, IL-17, and Foxp3 were not affected. These results indicate that higher levels of 4-1BB expression involve in promoting Th1 differentiation and enhancing specific CTL responses to PRRSV, and provide a novel approach to increase the efficacy of current vaccines to control the infectious diseases.

Human neonatal rotavirus vaccine (RV3-BB) targets rotavirus from birth

Science.gov (United States)

Thobari, Jarir At; Satria, Cahya Dewi; Handley, Amanda; Watts, Emma; Cowley, Daniel; Nirwati, Hera; Ackland, James; Standish, Jane; Justice, Frances; Byars, Gabrielle; Lee, Katherine J.; Barnes, Graeme L.; Bachtiar, Novilia S.; Icanervilia, Ajeng Viska; Boniface, Karen; Bogdanovic-Sakran, Nada; Pavlic, Daniel; Bishop, Ruth F.; Kirkwood, Carl D.; Buttery, Jim P.; Soenarto, Yati

2018-01-01

Background A birth dose strategy using a neonatal rotavirus vaccine to target early prevention of rotavirus disease may address remaining barriers to global vaccine implementation. Methods We conducted a randomized, placebo-controlled trial in Indonesia to evaluate the efficacy of an oral human neonatal rotavirus vaccine (RV3-BB) to prevent rotavirus gastroenteritis. Healthy newborns received three doses of RV3-BB administered in a neonatal schedule at 0-5 days, 8 and 14 weeks or infant schedule at 8, 14 and 18 weeks, or placebo. Laboratory-confirmed rotavirus gastroenteritis was graded using a modified Vesikari score. The primary analysis was efficacy against severe rotavirus gastroenteritis from two weeks after all doses to 18 months in the combined vaccine group (neonatal and infant schedule) compared with placebo. Results Vaccine efficacy against severe rotavirus gastroenteritis to 18 months was 63% in the combined vaccine group (95% CI 34, 80; p<0.001), 75% in the neonatal vaccine group (95% confidence interval [CI] 44, 91; p<0.001) and 51% in the infant vaccine group (95% CI 7, 76; p=0.03) in the per protocol analysis, with similar results in the intention-to-treat analysis. Vaccine efficacy to 12 months was 94% in the neonatal vaccine group (95%CI 56, 99; p=0.006). Vaccine take occurred in 78/83 (94%) in the neonatal vaccine group and 83/84 (99%) in the infant vaccine group. The vaccine was well tolerated, with similar incidence of adverse events in vaccine and placebo recipients. Conclusion RV3-BB was efficacious, immunogenic and well-tolerated when administered in a neonatal or infant schedule in Indonesia. PMID:29466164

Creatine kinase BB and beta-2-microglobulin as markers of CNS metastases in patients with small-cell lung cancer

DEFF Research Database (Denmark)

Pedersen, A G; Bach, F W; Nissen, Mogens Holst

1985-01-01

Creatine kinase (CK) and its BB isoenzyme (CK-BB) were measured in CSF in 65 evaluable patients suspected of CNS metastases secondary to small-cell lung cancer (SCLC). In addition, CSF and plasma levels of beta-2-microglobulin (beta-2-m) were measured in a group of 73 evaluable patients. Of the 65...

A disintegrin and metalloprotease-17 and galectin-9 are important regulators of local 4-1BB activity and disease outcome in rheumatoid arthritis

DEFF Research Database (Denmark)

Nielsen, Morten Aagaard; Andersen, Thomas; Etzerodt, Anders

2016-01-01

OBJECTIVE: Co-stimulatory T cell cytokines are important in the progression of RA. This study investigates the interplay between 4-1BB, a disintegrin and metalloprotease-17 (ADAM17) and galectin-9 (Gal-9) in RA. METHODS: Stimulated mononuclear cells from patients with chronic RA (n = 12) were co...... treatment outcome serially over a 2-year period. RESULTS: RA CD4(+) and CD8(+) synovial T cells express high levels of 4-1BB. The addition of TNF-α to cultured synovial mononuclear cells increased shedding of 4-1BB. 4-1BB ligand only increased TNF-α shedding in combination with Gal-9. RNA interference...

VHE gamma-rays from radio pulsars and cataclysmic variables. [PSR 1055-52; PSR 1509-58; PSR 1620-26; PSR 1747-46; PSR 1800-21; PSR 1818-04; PSR 1821-24; PSR 1822-09; PSR 1823-13; PSR 1855+09; PSR 1929+10; PSR 1957+20

Energy Technology Data Exchange (ETDEWEB)

De Jager, O.C.; Brink, C.; Meintjies, P.J.; Nel, H.I.; North, A.R.; Raubenheimer, B.C.; Van der Walt, D.J. (Potchefstroom Univ. for C.H.E. (South Africa). Dept. of Physics)

1990-03-01

We present the results of observations (above 1 TeV) of radio pulsars and cataclysmic variables with the Potchefstroom air Cerenkov facility. We were able to confirm our previous detection of PSR 1509-58 and the final significance is 1.7x10{sup -5}. A DC enhancement at the 10{sup -3} significance level was seen from the L{sub 4} Lagrange position in the PSR 1957+20 system. This result was confirmed by COS-B data. We were also able to detect the 5.4 ms pulsar PSR 1855+09 at a marginal significance level of 5%. However, the best and longest observation indicates non-uniformity at the 0.005 significance level. The TeV light curve resembles the radio light curve. The latter is also reminiscent of other millisecond pulsar observed above 1 TeV. The intermediate polar AEAQR (P = 33.08s) shows a period shift which is consistent with recent model predictions. However, the present significance of this results does not allow an unambiguous claim. (orig.).

Association between Virulence Factors and TRAF1/4-1BB/Bcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori

Directory of Open Access Journals (Sweden)

Fen Wang

2015-01-01

Full Text Available Objective. CagA+/vacAs1+/vacAm1+ Helicobacter pylori upregulates the expression of tumor necrosis factor receptor–associated factor 1 (TRAF1, tumor necrosis factor receptor superfamily member 9 (4-1BB, and B-cell lymphoma-extra large (Bcl-xL in human gastric epithelial cells. We investigated the correlation between cagA/vacAs1/vacAm1 and TRAF1/4-1BB/Bcl-xL expression in gastric mucosal tissue of patients with gastric disorders. Methods. We collected gastric mucosa samples from 35 chronic, nonatrophic gastritis (CG patients, 41 atrophic gastritis patients, 44 intestinal metaplasia with atypical hyperplasia (IM patients, and 28 gastric carcinoma (Ca patients. The expression of  TRAF1, 4-1BB, and Bcl-xL was determined using western blotting. The expression of cagA, vacAs1, and vacAm1 in H. pylori was examined with polymerase chain reaction. Results. The expression of TRAF1, 4-1BB, and Bcl-xL was significantly upregulated in IM and Ca patients (P<0.05 compared with CG. There were more cases of cagA+/vacAs1+/vacAm1+ H. pylori infection in samples with elevated TRAF1, 4-1BB, or Bcl-xL expression (P<0.05. Additionally, there were a remarkably large number of samples with upregulated TRAF1/4-1BB/Bcl-xL expression in cases of cagA+/vacAs1+/vacAm1+ H. pylori infection (44 cases, 67.7%; P<0.05. Conclusions. The pathogenesis of IM and Ca may be promoted by cagA+/vacAs1+/vacAm1+ H. pylori, possibly via upregulated TRAF1, 4-1BB, and Bcl-xL in gastric mucosal tissue.

Exploring the Hard and Soft X-ray Emission of Magnetic Cataclysmic Variables

Science.gov (United States)

de Martino, D.; Anzolin, G.; Bonnet-Bidaud, J.-M.; Falanga, M.; Matt, G.; Mouchet, M.; Mukai, K.; Masetti, N.

2009-05-01

A non-negligible fraction of galactic hard (>20 keV) X-ray sources were identified as CVs of the magnetic Intermediate Polar type in INTEGRAL, SWIFT and RXTE surveys, that suggests a still hidden but potentially important population of faint hard X-ray sources. Simbol-X has the unique potential to simultaneously characterize their variable and complex soft and hard X-ray emission thus allowing to understand their putative role in galactic populations of X-ray sources.

Application of central composite design to optimize the amount of carbon source and prebiotics for Bifidobacterium bifidum BB01

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Shu Guowei

2016-06-01

Full Text Available The objective of the present study was to obtain the optimum proportion of the carbon source and prebiotics for Bifidobacterium bifidum BB01 by the central composite design (CCD. The effect of carbon source (lactose and two prebiotics (inulin and fructooligosaccharides on the BB01 were observed by measuring the OD600 value, pH value and the viable counts at 18h. The final optimized concentrations of carbon source and prebiotics were: lactose 1.6%, inulin 0.26%, and fructooligosaccharides 0.22%. The result indicates that the growth of B. bifidum BB01 shows an significant increase in the optimized culture medium (p < 0.05, the OD600 value reached 1.434 at 18h, which increased 6.58% compared to the control. And the viable counts of B. bifidum BB01 increased 24.36% and reached (2.17±0.06 ×109cfu/mL. The results show that the optimization of the carbon source and prebiotics using CCD in this study is workable and necessary.

Selection of Co-Substrate and Aeration Conditions for Vanillin Production by Escherichia coli JM109/pBB1

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Paolo Torre

2004-01-01

Full Text Available Yeast extract, Luria-Bertani medium and tryptone were tested as co-substrates for vanillin production from ferulic acid by resting cells of Escherichia coli JM109/pBB1. Yeast extract proved to be the best component for sustaining such a bioconversion, which is not self-sustained from the bioenergetic point of view. Tests were also performed under variable aeration conditions by simultaneously varying the ratio of medium to vessel volume and the agitation speed. The results of these tests suggest that, under excess aeration, a non-specific oxidase activity was very likely responsible for the oxidation of a significant portion of vanillin to vanillic acid, thus reducing the vanillin yield.

La mort de Tupac Amaru, l’ultime cataclysme ?

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Nejma Jalal-Kermele

2011-06-01

Full Text Available L’exécution du jeune Inca Tupac Amaru en 1572 fut pour les Indiens du Pérou un véritable cataclysme. Il s’insérait dans un contexte particulier : celui de la vice-royauté du Pérou qui connaissait, depuis de longues années, une série de guerres et de complots. Au cœur de cet espace troublé, se trouvait un royaume néo-inca que la Couronne espérait vaincre par une politique du compromis. Toledo, envoyé pour faire rentrer le Pérou dans un ordre nouveau, avait marqué, dès le début de son gouvernement, son opposition au régime de Vilcabamba dont la seule présence fragilisait la légitimité du pouvoir du roi de Castille aux Indes. C’était donc la question des Justes Titres qui préoccupait Toledo, décidé à lutter activement contre la pensée de Las Casas. La mort d’un messager, envoyé pour négocier avec l’Inca, servit de prétexte à une attaque de Vilcabamba qui permit l’arrestation du jeune Tupac Amaru que le vice-roi décida de condamner à mort, en dépit de sa conversion au catholicisme. L’exécution marqua pour les Indiens la fin d’un monde, la fin d’un espoir et apparut comme l’ultime catastrophe, une répétition de la mort de l’Inca et des Dieux. De nombreux récits rapportent la détresse infinie des Indiens et la désapprobation quasi générale des témoins. Nous voudrions proposer ici une rapide analyse des différentes lectures du cataclysme et tenter de montrer que, pour Toledo, il s’inséra dans une politique claire et assumée. Outre la question idéologique, le vice-roi s’appuya sur des arguments sécuritaires et fit finalement de Tupac Amaru non un prince mais un simple délinquant de droit commun. Cette réécriture de l’Histoire permit d’instaurer une nouvelle définition de la politique espagnole au Pérou mais le cataclysme marqua les esprits et Tupac Amaru, loin d’être oublié, devint un symbole qui traversa les siècles jusqu’à aujourd’hui.La ejecución del joven

Slow-roll inflation and BB-mode angular power spectrum of CMB

Energy Technology Data Exchange (ETDEWEB)

Malsawmtluangi, N.; Suresh, P.K. [University of Hyderabad, School of Physics, Hyderabad (India)

2016-05-15

The BB-mode correlation angular power spectrum of CMB is obtained by considering the primordial gravitational waves in the squeezed vacuum state for various inflationary models and results are compared with the joint analysis of the BICEP2/Keck Array and Planck 353 GHz data. The present results may constrain several models of inflation. (orig.)

Predictive modeling of Bifidobacterium animalis subsp. lactis Bb-12 growth in cow’s, goat’s and soy milk

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Vedran Slačanac

2013-11-01

Full Text Available The aim of this study was to use a predictive model to analyse the growth of a probiotic strain Bifidobacterium animalis subsp. lactis Bb-12 in cow’s, goat’s and soy milk. The Gompertz model was used, and the suitability of the model was estimated by the Schnute algorithm. Except for the analysis of Bifidobacterium animalis subsp. lactis Bb-12 growth, the Gompertz model was also used for the analysis of pH changes during the fermentation process. Experimental results, as well as the values of kinetic parameters obtained in this study, showed that the highest growth rate of Bifidobacterium animalis subsp. lactis Bb-12 was obtained in goat’s milk, and the lowest in soy milk. Contrary to the growth of Bifidobacterium animalis subsp. lactis Bb-12, pH decreased faster in soy milk than in cow’s milk. The highest rate of pH decrease was also observed in goat’s milk, which is in correspondence with results of various previous studies. The Gompertz model proved to be highly suitable for analysing the course and the fermentation kinetics in these three kinds of milk, and might be used to analyse the growth kinetics of other probiotic and starter cultures in milk.

Radioimmunoassay measurement of creatine kinase BB in the serum of schizophrenic patients

Energy Technology Data Exchange (ETDEWEB)

Lerner, M H; Friedhoff, A J [New York Univ., NY (USA). Medical Center

1980-10-23

Brain type creatine kinase (BB) isoenzyme was measured using a highly sensitive and specific radioimmunoassay procedure (limit of detection, 1 ..mu..g/l of sample) in two schizophrenic populations, an acute non-medicated group consisting of 35 subjects and a chronic group of 15 subjects. Since the assay can also measure the B subunit of MB isoenzyme, patients were selected so as to exclude subjects with possible heart, kidney or other ailments which might result in an increased serum creatine kinase B subunit. Both the acute schizophrenics (3.0 +- 0.23) x S.E.M. and the chronic schizophrenics (2.9 +- 0.33) had serum levels of creatine kinase BB similar to those of controls (2.8 +- 0.21) and non-cardiac patients (3.5 +- 0.58). Patients having myocardial infarction or neurovascular surgery had elevated creatine kinase B subunit. Similar but much less sensitive quantitative results were obtained using agarose multizonal electrophoresis.

Radioimmunoassay measurement of creatine kinase BB in the serum of schizophrenic patients

International Nuclear Information System (INIS)

Lerner, M.H.; Friedhoff, A.J.

1980-01-01

Brain type creatine kinase (BB) isoenzyme was measured using a highly sensitive and specific radioimmunoassay procedure (limit of detection, 1 μg/l of sample) in two schizophrenic populations, an acute non-medicated group consisting of 35 subjects and a chronic group of 15 subjects. Since the assay can also measure the B subunit of MB isoenzyme, patients were selected so as to exclude subjects with possible heart, kidney or other ailments which might result in an increased serum creatine kinase B subunit. Both the acute schizophrenics (3.0 +- 0.23) x S.E.M. and the chronic schizophrenics (2.9 +- 0.33) had serum levels of creatine kinase BB similar to those of controls (2.8 +- 0.21) and non-cardiac patients (3.5 +- 0.58). Patients having myocardial infarction or neurovascular surgery had elevated creatine kinase B subunit. Similar but much less sensitive quantitative results were obtained using agarose multizonal electrophoresis. (Auth.)

The interoutburst behavior of cataclysmic variables

International Nuclear Information System (INIS)

Szkody, P.; Stablein, C.; Mattei, J.A.; Waagen, E.O.

1991-01-01

Existing IUE and AAVSO archive data were used to accomplish a large scale study of what happens to the UV flux of accretion disk systems during the quiescent intervals between outbursts, and how it relates to the preceding outburst characteristics of amplitude and width. The data sample involved multiple IUE observations for 16 dwarf novae and 8 novae along with existing optical coverage. Results indicate that most systems show correlated UV flux behavior with interoutburst phase, with 60 percent of the dwarf novae and 50 percent of the novae having decreasing flux trends while 33 percent of the dwarf novae and 38 percent of the novae show rising UV flux during the quiescent interval. All of the dwarf novae with decreasing UV fluxes at 1475 A have orbital periods longer than 4.4 hours, while all (except BV Cen) with flat or rising fluxes at 1475 A have orbital periods less than two hours. From a small sample (7) that have relatively large quiescent V magnitude changes between the IUE observations, most show a strong correlation between the UV and optical continuum. Interpretation of the results is complicated by not being able to determine how much the white dwarf contributes to the ultraviolet flux. However, it is now evident that noticeable changes are occurring in the hot zones in accreting systems long after the outburst, and not only for systems that are dominated by the white dwarf. 25 refs

The Magnetospheric Boundary in Cataclysmic Variables

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Hellier Coel

2014-01-01

During outbursts, when the accretion flow increases by orders of magnitude, the disk pushes the magnetosphere inwards, and appears to feed field lines over a much greater range of magnetic azimuth. The non-equilibrium outburst behaviour shows an even richer phenomenology than in quiescence, adding DNOs and QPOs into the mix.

Tehokkuutta B&B Purola Farmin digitaaliseen markkinointiviestintään

OpenAIRE

Luoma-aho, Lilli

2016-01-01

Opinnäytetyön tarkoituksena oli selvittää, miten B&B Purola Farmin markkinointia saadaan tehostettua ja kohdennettua digitaalisen markkinointiviestinnän keinoin, yleisesti ja keskittyen hollantilaisiin, sveitsiläisiin ja luxemburgilaisiin matkailijoihin. Tavoitteena oli syventää ymmärrystä siitä, miten digitaalista markkinointiviestintää tulee toteuttaa toivottujen kohderyhmien tavoittamiseksi. Opinnäytetyöhön tietoa kerättiin aiheesta kertovasta kirjallisuudesta ja asiantuntijablogeista. ...

Spatiotemporal modes of climatic variability: building blocks of complex networks?

Czech Academy of Sciences Publication Activity Database

Vejmelka, Martin; Hlinka, Jaroslav; Hartman, David; Paluš, Milan

2012-01-01

Roč. 14, - (2012), s. 14275 ISSN 1607-7962. [European Geosciences Union General Assembly 2012. 22.04.2012-27.04.2012, Vienna] R&D Projects: GA ČR GCP103/11/J068 Institutional support: RVO:67985807 Keywords : climate variability * dimensionality reduction * principal component analysis * surrogate data * climate network Subject RIV: BB - Applied Statistics, Operational Research

Hybrid CATV/MMW/BB lightwave transmission system based on fiber-wired/fiber-wireless/fiber-VLLC integrations.

Science.gov (United States)

Li, Chung-Yi; Lu, Hai-Han; Lu, Ting-Chieh; Chu, Chien-An; Chen, Bo-Rui; Lin, Chun-Yu; Peng, Peng-Chun

2015-12-14

A hybrid lightwave transmission system for cable television (CATV)/millimeter-wave (MMW)/baseband (BB) signal transmission based on fiber-wired/fiber-wireless/fiber-visible laser light communication (VLLC) integrations is proposed and demonstrated. For down-link transmission, the light is intensity-modulated with 50-550 MHz CATV signal and optically promoted from 25 GHz radio frequency (RF) signal to 10 Gbps/50 GHz and 20 Gbps/100 GHz MMW data signals based on fiber-wired and fiber-wireless integrations. Good performances of carrier-to-noise ratio (CNR), composite second-order (CSO), composite triple-beat (CTB), and bit error rate (BER) are obtained over a 40-km single-mode fiber (SMF) and a 10-m RF wireless transport. For up-link transmission, the light is successfully intensity-remodulated with 5-Gbps BB data stream based on fiber-VLLC integration. Good BER performance is achieved over a 40-km SMF and a 10-m free-space VLLC transport. Such a hybrid CATV/MMW/BB lightwave transmission system is an attractive alternative, it gives the benefits of a communication link for broader bandwidth and higher transmission rate.

On Solving Aircraft Conflict Avoidance Using Deterministic Global Optimization (sBB) Codes

OpenAIRE

Cafieri , Sonia; Messine , Frédéric; Touhami , Ahmed

2016-01-01

International audience; In this paper, some improvements of spatial Branch and Bound (sBB) algorithms are discussed to solve aircraft conflict avoidance problems formulated as MINLP. We propose a new quadratic convex relaxation technique based on affine arithmetic. Moreover, a branching strategy is also proposedfor the considered problem. Preliminary numerical results validates the proposed approach

Dual delivery of rhPDGF-BB and bone marrow mesenchymal stromal cells expressing the BMP2 gene enhance bone formation in a critical-sized defect model.

Science.gov (United States)

Park, Shin-Young; Kim, Kyoung-Hwa; Shin, Seung-Yun; Koo, Ki-Tae; Lee, Yong-Moo; Seol, Yang-Jo

2013-11-01

Bone tissue healing is a dynamic, orchestrated process that relies on multiple growth factors and cell types. Platelet-derived growth factor-BB (PDGF-BB) is released from platelets at wound sites and induces cellular migration and proliferation necessary for bone regeneration in the early healing process. Bone morphogenetic protein-2 (BMP-2), the most potent osteogenic differentiation inducer, directs new bone formation at the sites of bone defects. This study evaluated a combinatorial treatment protocol of PDGF-BB and BMP-2 on bone healing in a critical-sized defect model. To mimic the bone tissue healing process, a dual delivery approach was designed to deliver the rhPDGF-BB protein transiently during the early healing phase, whereas BMP-2 was supplied by rat bone marrow stromal cells (BMSCs) transfected with an adenoviral vector containing the BMP2 gene (AdBMP2) for prolonged release throughout the healing process. In in vitro experiments, the dual delivery of rhPDGF-BB and BMP2 significantly enhanced cell proliferation. However, the osteogenic differentiation of BMSCs was significantly suppressed even though the amount of BMP-2 secreted by the AdBMP2-transfected BMSCs was not significantly affected by the rhPDGF-BB treatment. In addition, dual delivery inhibited the mRNA expression of BMP receptor type II and Noggin in BMSCs. In in vivo experiments, critical-sized calvarial defects in rats showed enhanced bone regeneration by dual delivery of autologous AdBMP2-transfected BMSCs and rhPDGF-BB in both the amount of new bone formed and the bone mineral density. These enhancements in bone regeneration were greater than those observed in the group treated with AdBMP2-transfected BMSCs alone. In conclusion, the dual delivery of rhPDGF-BB and AdBMP2-transfected BMSCs improved the quality of the regenerated bone, possibly due to the modulation of PDGF-BB on BMP-2-induced osteogenesis.

The cc-bar and bb-bar spectroscopy in the two-step potential model

International Nuclear Information System (INIS)

Kulshreshtha, D.S.; Kaiserslautern Univ.

1984-07-01

We investigate the spectroscopy of the charmonium (cc-bar) and bottonium (bb-bar) bound states in a static flavour independent nonrelativistic quark-antiquark (qq-bar) two-step potential model proposed earlier. Our predictions are in good agreement with experimental data and with other theoretical predictions. (author)

Treatment of acute lymphoblastic leukaemia with the second generation of CD19 CAR-T containing either CD28 or 4-1BB.

Science.gov (United States)

Li, Shiqi; Zhang, Jiasi; Wang, Meiling; Fu, Gang; Li, Yunyan; Pei, Li; Xiong, Zhouxing; Qin, Dabing; Zhang, Rui; Tian, Xiaobo; Wei, Zhihao; Chen, Run; Chen, Xuejiao; Wan, Jia; Chen, Jun; Wei, Xia; Xu, Yanmin; Zhang, Pei; Wang, Ping; Peng, Xi; Yang, Sainan; Shen, Junjie; Yang, Zhi; Chen, Jieping; Qian, Cheng

2018-04-10

T cells modified with anti-CD19 chimeric antigen receptor (CAR) containing either CD28 or 4-1BB (also termed TNFRSF9, CD137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia (ALL). However, the difference between CD28 and 4-1BB costimulatory signalling in CAR-T treatment has not been well elucidated in clinical trials. In this study, we treated 10 relapsed or refractory ALL patients with the second generation CD19 CAR-T. The first 5 patients were treated with CD28-CAR and the other 5 patients were treated with 4-1BB CAR-T. All the 10 patients were response-evaluable. Three patients achieved complete remission and 1 patient with extramedullary disease achieved partial response after CD28-CAR-T treatment. In the 4-1BB CAR-T treatment group, 3 patients achieved complete remission. Furthermore, FLT-3 ligand (FLT3LG) was highly correlated with response time and may serve as a prognosis factor. No severe adverse events were observed in these 10 treated patients. Our study showed that both CD28 CAR-T and 4-1BB CAR-T both worked for response but they differed in response pattern (peak reaction time, reaction lasting time and reaction degree), adverse events, cytokine secretion and immune-suppressive factor level. © 2018 John Wiley & Sons Ltd.

Identification and characterization of an insect toxin protein, Bb70p, from the entomopathogenic fungus, Beauveria bassiana, using Galleria mellonella as a model system.

Science.gov (United States)

Khan, Sehroon; Nadir, Sadia; Lihua, Guo; Xu, Jianchu; Holmes, Keith A; Dewen, Qiu

2016-01-01

An insect-toxic protein, Bb70p, was purified from Beauveria bassiana 70 using ammonium sulfate precipitation, ion exchange chromatography, and gel filtration. Bb70p has a high affinity for anion exchangers and 2D electrophoresis results revealed a single spot with a molecular weight of 35.5 kDa and an iso-electric point of ∼4.5. Bb70p remains active from 4 to 60°C, within a pH range of 4-10, but is more active in slightly acidic pH. A pure protein, Bb70p does not have any carbohydrate side chains. The protein caused high mortality by intra-haemocelic injection into Galleria mellonella with LD50 of 334.4 μg/g body weight and activates the phenol oxidase cascade. With a partial amino acid sequence comparison using the NCBI database, we showed no homology to known toxin proteins of entomopathogenic fungi. Thus, Bb70p appears to be an insect toxin protein, demonstrating novelty. Identification of this insect-toxic protein presents potential to enhance the virulence of B. bassiana through genetic manipulation. Copyright © 2015 Elsevier Inc. All rights reserved.

Consumption of Bifidobacterium animalis subsp. lactis BB-12 in yogurt reduced expression of TLR-2 on peripheral blood-derived monocytes and pro-inflammatory cytokine secretion in young adults.

Science.gov (United States)

Meng, Huicui; Ba, Zhaoyong; Lee, Yujin; Peng, Jiayu; Lin, Junli; Fleming, Jennifer A; Furumoto, Emily J; Roberts, Robert F; Kris-Etherton, Penny M; Rogers, Connie J

2017-03-01

Probiotic bacteria modulate immune parameters and inflammatory outcomes. Emerging evidence demonstrates that the matrix used to deliver probiotics may influence the efficacy of probiotic interventions in vivo. The aims of the current study were to evaluate (1) the effect of one species, Bifidobacterium animalis subsp. lactis BB-12 at a dose of log10 ± 0.5 CFUs/day on immune responses in a randomized, partially blinded, 4-period crossover, free-living study, and (2) whether the immune response to BB-12 differed depending on the delivery matrix. Healthy adults (n = 30) aged 18-40 years were recruited and received four treatments in a random order: (A) yogurt smoothie alone; smoothie with BB-12 added (B) before or (C) after yogurt fermentation, or (D) BB-12 given in capsule form. At baseline and after each 4-week treatment, peripheral blood mononuclear cells (PBMCs) were isolated, and functional and phenotypic marker expression was assessed. BB-12 interacted with peripheral myeloid cells via Toll-like receptor 2 (TLR-2). The percentage of CD14 + HLA-DR + cells in peripheral blood was increased in male participants by all yogurt-containing treatments compared to baseline (p = 0.0356). Participants who consumed yogurt smoothie with BB-12 added post-fermentation had significantly lower expression of TLR-2 on CD14 + HLA-DR + cells (p = 0.0186) and reduction in TNF-α secretion from BB-12- (p = 0.0490) or LPS-stimulated (p = 0.0387) PBMCs compared to baseline. These findings not only demonstrate a potential anti-inflammatory effect of BB-12 in healthy adults, but also indicate that the delivery matrix influences the immunomodulatory properties of BB-12.

Camptothecin inhibits platelet-derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells through inhibition of PI3K/Akt signaling pathway

Energy Technology Data Exchange (ETDEWEB)

Park, Eun-Seok [Department of Applied Biochemistry, Division of Life Science, College of Health and Biomedical Science, Konkuk University, Chungju, Chungbuk (Korea, Republic of); Kang, Shin-il [College of Pharmacy Medical Research Center, Chungbuk National University, Cheongju (Korea, Republic of); Yoo, Kyu-dong [Hazardous Substances Analysis Division, Gwangju Regional Food and Drug Administration, Gwangju (Korea, Republic of); Lee, Mi-Yea [Department of Nursing Kyungbok University, Pocheon (Korea, Republic of); Yoo, Hwan-Soo; Hong, Jin-Tae [College of Pharmacy Medical Research Center, Chungbuk National University, Cheongju (Korea, Republic of); Shin, Hwa-Sup [Department of Applied Biochemistry, Division of Life Science, College of Health and Biomedical Science, Konkuk University, Chungju, Chungbuk (Korea, Republic of); Kim, Bokyung [Department of Physiology, Konkuk Medical School, Konkuk University, Chungju, Chungbuk (Korea, Republic of); Yun, Yeo-Pyo, E-mail: ypyun@chungbuk.ac.kr [College of Pharmacy Medical Research Center, Chungbuk National University, Cheongju (Korea, Republic of)

2013-04-15

The abnormal proliferation of vascular smooth muscle cells (VSMCs) in arterial wall is a major cause of vascular disorders such as atherosclerosis and restenosis after angioplasty. In this study, we investigated not only the inhibitory effects of camptothecin (CPT) on PDGF-BB-induced VSMC proliferation, but also its molecular mechanism of this inhibition. CPT significantly inhibited proliferation with IC50 value of 0.58 μM and the DNA synthesis of PDGF-BB-stimulated VSMCs in a dose-dependent manner (0.5–2 μM ) without any cytotoxicity. CPT induced the cell cycle arrest at G0/G1 phase. Also, CPT decreased the expressions of G0/G1-specific regulatory proteins including cyclin-dependent kinase (CDK)2, cyclin D1 and PCNA in PDGF-BB-stimulated VSMCs. Pre-incubation of VSMCs with CPT significantly inhibited PDGF-BB-induced Akt activation, whereas CPT did not affect PDGF-receptor beta phosphorylation, extracellular signal-regulated kinase (ERK) 1/2 phosphorylation and phospholipase C (PLC)-γ1 phosphorylation in PDGF-BB signaling pathway. Our data showed that CPT pre-treatment inhibited VSMC proliferation, and that the inhibitory effect of CPT was enhanced by LY294002, a PI3K inhibitor, on PDGF-BB-induced VSMC proliferation. In addition, inhibiting the PI3K/Akt pathway by LY294002 significantly enhanced the suppression of PCNA expression and Akt activation by CPT. These results suggest that the anti-proliferative activity of CPT is mediated in part by downregulating the PI3K/Akt signaling pathway. - Highlights: ► CPT inhibits proliferation of PDGF-BB-induced VSMC without cytotoxicity. ► CPT arrests the cell cycle in G0/G1 phase by downregulation of cyclin D1 and CDK2. ► CPT significantly attenuates Akt phosphorylation in PDGF-BB signaling pathway. ► LY294002 enhanced the inhibitory effect of CPT on VSMC proliferation. ► Thus, CPT is mediated by downregulating the PI3K/Akt signaling pathway.

Camptothecin inhibits platelet-derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells through inhibition of PI3K/Akt signaling pathway

International Nuclear Information System (INIS)

Park, Eun-Seok; Kang, Shin-il; Yoo, Kyu-dong; Lee, Mi-Yea; Yoo, Hwan-Soo; Hong, Jin-Tae; Shin, Hwa-Sup; Kim, Bokyung; Yun, Yeo-Pyo

2013-01-01

The abnormal proliferation of vascular smooth muscle cells (VSMCs) in arterial wall is a major cause of vascular disorders such as atherosclerosis and restenosis after angioplasty. In this study, we investigated not only the inhibitory effects of camptothecin (CPT) on PDGF-BB-induced VSMC proliferation, but also its molecular mechanism of this inhibition. CPT significantly inhibited proliferation with IC50 value of 0.58 μM and the DNA synthesis of PDGF-BB-stimulated VSMCs in a dose-dependent manner (0.5–2 μM ) without any cytotoxicity. CPT induced the cell cycle arrest at G0/G1 phase. Also, CPT decreased the expressions of G0/G1-specific regulatory proteins including cyclin-dependent kinase (CDK)2, cyclin D1 and PCNA in PDGF-BB-stimulated VSMCs. Pre-incubation of VSMCs with CPT significantly inhibited PDGF-BB-induced Akt activation, whereas CPT did not affect PDGF-receptor beta phosphorylation, extracellular signal-regulated kinase (ERK) 1/2 phosphorylation and phospholipase C (PLC)-γ1 phosphorylation in PDGF-BB signaling pathway. Our data showed that CPT pre-treatment inhibited VSMC proliferation, and that the inhibitory effect of CPT was enhanced by LY294002, a PI3K inhibitor, on PDGF-BB-induced VSMC proliferation. In addition, inhibiting the PI3K/Akt pathway by LY294002 significantly enhanced the suppression of PCNA expression and Akt activation by CPT. These results suggest that the anti-proliferative activity of CPT is mediated in part by downregulating the PI3K/Akt signaling pathway. - Highlights: ► CPT inhibits proliferation of PDGF-BB-induced VSMC without cytotoxicity. ► CPT arrests the cell cycle in G0/G1 phase by downregulation of cyclin D1 and CDK2. ► CPT significantly attenuates Akt phosphorylation in PDGF-BB signaling pathway. ► LY294002 enhanced the inhibitory effect of CPT on VSMC proliferation. ► Thus, CPT is mediated by downregulating the PI3K/Akt signaling pathway

Continuous 4-1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy.

Science.gov (United States)

Chacon, Jessica Ann; Pilon-Thomas, Shari; Sarnaik, Amod A; Radvanyi, Laszlo G

2013-09-01

Co-stimulation through members of the tumor necrosis factor receptor (TNFR) family appears to be critical for the generation of T cells with optimal effector-memory properties for adoptive cell therapy. Our work suggests that continuous 4-1BB/CD137 co-stimulation is required for the expansion of T cells with an optimal therapeutic profile and that the administration of 4-1BB agonists upon adoptive cell transfer further improves antitumor T-cell functions.

BB0347, from the lyme disease spirochete Borrelia burgdorferi, is surface exposed and interacts with the CS1 heparin-binding domain of human fibronectin.

Directory of Open Access Journals (Sweden)

Robert A Gaultney

Full Text Available The causative agent of Lyme disease, Borrelia burgdorferi, codes for several known fibronectin-binding proteins. Fibronectin a common the target of diverse bacterial pathogens, and has been shown to be essential in allowing for the development of certain disease states. Another borrelial protein, BB0347, has sequence similarity with these other known fibronectin-binding proteins, and may be important in Lyme disease pathogenesis. Herein, we perform an initial characterization of BB0347 via the use of molecular and biochemical techniques. We found that BB0347 is expressed, produced, and presented on the outer surface of intact B. burgdorferi. We also demonstrate that BB0347 has the potential to be important in Lyme disease progression, and have begun to characterize the nature of the interaction between human fibronectin and this bacterial protein. Further work is needed to define the role of this protein in the borrelial infection process.

76 FR 13615 - B&B Manufacturing Site; Mobile, Mobile County, AL; Notice of Settlement

Science.gov (United States)

2011-03-14

... settlement for reimbursement of past response costs concerning the B&B Manufacturing Site located in Mobile, Mobile County, Alabama for publication. DATES: The Agency will consider public comments on the settlement... Site; Mobile, Mobile County, AL; Notice of Settlement AGENCY: Environmental Protection Agency. ACTION...

Boosted H­->bb Tagger In Run II

CERN Document Server

Sahinsoy, Merve; The ATLAS collaboration

2016-01-01

Several searches for Higgs bosons decaying to b­quark pairs benefit from the increased Run II centre­of­mass energy by exploiting the large transvers­momentum (boosted) Higgs boson regime, where the two b­jets are merged into one large­radius jet. ATLAS uses a boosted H­>bb tagger algorithm to separate the Higgs signal from the background processes (QCD, W and Z bosons, top quarks). The tagger takes as input a large­R=1.0 jet calibrating the pseudorapidity, energy and mass scale. The tagger employs b­tagging, Higgs candidate mass, and substructure information. The performance of several operating points in Higgs boson signal and QCD and ttbar all­hadronic backgrounds are presented. Systematic uncertainties are evaluated so that this tagger can be used in analyses.

The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B

Directory of Open Access Journals (Sweden)

Antonio F. Mendes-Sousa

2017-08-01

Full Text Available Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP. Lufaxin inhibited the deposition of C3b, Bb, Properdin, C5b, and C9b on agarose-coated plates in a dose-dependent manner. It also inhibited the activation of factor B in normal serum, but had no effect on the components of the membrane attack complex. Surface plasmon resonance (SPR experiments demonstrated that Lufaxin stabilizes the C3b-B proconvertase complex when passed over a C3b surface in combination with factor B. Lufaxin was also shown to inhibit the activation of factor B by factor D in a reconstituted C3b-B, but did not inhibit the activation of C3 by reconstituted C3b-Bb. Proconvertase stabilization does not require the presence of divalent cations, but addition of Ni2+ increases the stability of complexes formed on SPR surfaces. Stabilization of the C3b-B complex to prevent C3 convertase formation (C3b-Bb formation is a novel mechanism that differs from previously described strategies used by other organisms to inhibit the AP of the host complement system.

The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B.

Science.gov (United States)

Mendes-Sousa, Antonio F; do Vale, Vladimir Fazito; Silva, Naylene C S; Guimaraes-Costa, Anderson B; Pereira, Marcos H; Sant'Anna, Mauricio R V; Oliveira, Fabiano; Kamhawi, Shaden; Ribeiro, José M C; Andersen, John F; Valenzuela, Jesus G; Araujo, Ricardo N

2017-01-01

Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP. Lufaxin inhibited the deposition of C3b, Bb, Properdin, C5b, and C9b on agarose-coated plates in a dose-dependent manner. It also inhibited the activation of factor B in normal serum, but had no effect on the components of the membrane attack complex. Surface plasmon resonance (SPR) experiments demonstrated that Lufaxin stabilizes the C3b-B proconvertase complex when passed over a C3b surface in combination with factor B. Lufaxin was also shown to inhibit the activation of factor B by factor D in a reconstituted C3b-B, but did not inhibit the activation of C3 by reconstituted C3b-Bb. Proconvertase stabilization does not require the presence of divalent cations, but addition of Ni 2+ increases the stability of complexes formed on SPR surfaces. Stabilization of the C3b-B complex to prevent C3 convertase formation (C3b-Bb formation) is a novel mechanism that differs from previously described strategies used by other organisms to inhibit the AP of the host complement system.

The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B

Science.gov (United States)

Mendes-Sousa, Antonio F.; do Vale, Vladimir Fazito; Silva, Naylene C. S.; Guimaraes-Costa, Anderson B.; Pereira, Marcos H.; Sant’Anna, Mauricio R. V.; Oliveira, Fabiano; Kamhawi, Shaden; Ribeiro, José M. C.; Andersen, John F.; Valenzuela, Jesus G.; Araujo, Ricardo N.

2017-01-01

Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP. Lufaxin inhibited the deposition of C3b, Bb, Properdin, C5b, and C9b on agarose-coated plates in a dose-dependent manner. It also inhibited the activation of factor B in normal serum, but had no effect on the components of the membrane attack complex. Surface plasmon resonance (SPR) experiments demonstrated that Lufaxin stabilizes the C3b-B proconvertase complex when passed over a C3b surface in combination with factor B. Lufaxin was also shown to inhibit the activation of factor B by factor D in a reconstituted C3b-B, but did not inhibit the activation of C3 by reconstituted C3b-Bb. Proconvertase stabilization does not require the presence of divalent cations, but addition of Ni2+ increases the stability of complexes formed on SPR surfaces. Stabilization of the C3b-B complex to prevent C3 convertase formation (C3b-Bb formation) is a novel mechanism that differs from previously described strategies used by other organisms to inhibit the AP of the host complement system. PMID:28912782

A theoretical model of the tridimensional structure of Bacillus thuringiensis subsp. medellin Cry 11Bb toxin deduced by homology modelling

Directory of Open Access Journals (Sweden)

Gutierrez Pablo

2001-01-01

Full Text Available Cry11Bb is an insecticidal crystal protein produced by Bacillus thuringiensis subsp. medellin during its stationary phase; this ¶-endotoxin is active against dipteran insects and has great potential for mosquito borne disease control. Here, we report the first theoretical model of the tridimensional structure of a Cry11 toxin. The tridimensional structure of the Cry11Bb toxin was obtained by homology modelling on the structures of the Cry1Aa and Cry3Aa toxins. In this work we give a brief description of our model and hypothesize the residues of the Cry11Bb toxin that could be important in receptor recognition and pore formation. This model will serve as a starting point for the design of mutagenesis experiments aimed to the improvement of toxicity, and to provide a new tool for the elucidation of the mechanism of action of these mosquitocidal proteins.

Non-resonant Higgs-pair production in the b anti bb anti b final state at the LHC

Energy Technology Data Exchange (ETDEWEB)

Wardrope, David; Jansen, Eric; Konstantinidis, Nikos; Cooper, Ben; Falla, Rebecca; Norjoharuddeen, Nurfikri [University College London, Department of Physics and Astronomy, London (United Kingdom)

2015-05-15

We present a particle-level study of the Standard Model non-resonant Higgs-pair production process in the b anti bb anti b final state, at the Large Hadron Collider at √(s) = 14 TeV. Each Higgs boson is reconstructed from a pair of close-by jets formed with the anti-k{sub t} jet clustering algorithm, with radius parameter R = 0.4. Given the kinematic properties of the produced Higgs bosons, this Higgs reconstruction approach appears to be more suitable than the use of largeradius jets that was previously proposed in the literature.We find that the sensitivity for observing this final state can be improved significantly when the full set of uncorrelated angular and kinematic variables of the 4b system is exploited, leading to a statistical significance of 1.8 per experiment with an integrated luminosity of 3 ab{sup -1}. (orig.)

Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats.

Science.gov (United States)

Watts, Tammara; Berti, Irene; Sapone, Anna; Gerarduzzi, Tania; Not, Tarcisio; Zielke, Ronald; Fasano, Alessio

2005-02-22

Increased intestinal permeability has been observed in numerous human autoimmune diseases, including type-1 diabetes (T1D) and its' animal model, the BB-wor diabetic prone rat. We have recently described zonulin, a protein that regulates intercellular tight junctions. The objective of this study was to establish whether zonulin-dependent increased intestinal permeability plays a role in the pathogenesis of T1D. In the BB diabetic-prone rat model of T1D, intestinal intraluminal zonulin levels were elevated 35-fold compared to control BB diabetic-resistant rats. Zonulin up-regulation was coincident with decreased small intestinal transepithelial electrical resistance, and was followed by the production of autoantibodies against pancreatic beta cells, which preceded the onset of clinically evident T1D by approximately 25 days. In those diabetic prone rats that did not progress to diabetes, both intraluminal zonulin and transepithelial electrical resistance were similar to those detected in diabetic-resistant animal controls. Blockade of the zonulin receptor reduced the cumulative incidence of T1D by 70%, despite the persistence of intraluminal zonulin up-regulation. Moreover, treatment responders did not seroconvert to islet cell antibodies. Combined together, these findings suggest that the zonulin-induced loss in small intestinal barrier function is involved in the pathogenesis of T1D in the BB diabetic-prone animal model.

Search for the H->bb decay in LHCb

CERN Document Server

Vieites Díaz, María

2014-01-01

The recent discovery of a Higgs-like boson by ATLAS and CMS has drawn the general attention to this topic, promoting the development of tools needed for the study of this new particle. The mass of this boson has been found to be close to 125 GeV=c2, what, as shown in Figure 1, enhances the H ! bb mode over the other possible decays of this particle. Since the mass of the Higgs boson has to be reconstructed from two jets, this mode is particularly challenging in LHCb due to its limited acceptance (when compared with ATLAS or CMS). However, jet b-tagging is expected to be easier due to the highly specic design for b-physics of the detector.

WR 120bb and WR 120bc: a pair of WN9h stars with possibly interacting circumstellar shells

Science.gov (United States)

Burgemeister, S.; Gvaramadze, V. V.; Stringfellow, G. S.; Kniazev, A. Y.; Todt, H.; Hamann, W.-R.

2013-03-01

Two optically obscured Wolf-Rayet (WR) stars have been recently discovered by means of their infrared (IR) circumstellar shells, which show signatures of interaction with each other. Following the systematics of the WR star catalogues, these stars obtain the names WR 120bb and WR 120bc. In this paper, we present and analyse new near-IR, J-, H- and K-band spectra using the Potsdam Wolf-Rayet model atmosphere code. For that purpose, the atomic data base of the code has been extended in order to include all significant lines in the near-IR bands. The spectra of both stars are classified as WN9h. As their spectra are very similar the parameters that we obtained by the spectral analyses hardly differ. Despite their late spectral subtype, we found relatively high stellar temperatures of 63 kK. The wind composition is dominated by helium, while hydrogen is depleted to 25 per cent by mass. Because of their location in the Scutum-Centaurus Arm, WR 120bb and WR 120bc appear highly reddened, A_{K_s} ≈ 2 mag. We adopt a common distance of 5.8 kpc to both stars, which complies with the typical absolute K-band magnitude for the WN9h subtype of -6.5 mag, is consistent with their observed extinction based on comparison with other massive stars in the region, and allows for the possibility that their shells are interacting with each other. This leads to luminosities of log ({textit {L}/L}_{odot }) = 5.66 and 5.54 for WR 120bb and WR 120bc, with large uncertainties due to the adopted distance. The values of the luminosities of WR 120bb and WR 120bc imply that the immediate precursors of both stars were red supergiants (RSG). This implies in turn that the circumstellar shells associated with WR 120bb and WR 120bc were formed by interaction between the WR wind and the dense material shed during the preceding RSG phase.

Pulsed estrogen therapy prevents post-OVX porcine dura mater microvascular network weakening via a PDGF-BB-dependent mechanism.

Directory of Open Access Journals (Sweden)

Olga V Glinskii

Full Text Available In postmenopausal women, estrogen (E2 deficiencies are frequently associated with higher risk of intracranial hemorrhage, increased incidence of stroke, cerebral aneurysm, and decline in cognitive abilities. In younger postpartum women and those using oral contraceptives, perturbations in E2 are associated with higher risk of cerebral venous thrombosis. A number of serious intracranial pathologic conditions linked to E2 deficiencies, such as dural sinus thrombosis, dural fistulae, non-parenchymal intracranial hemorrhages, migraines, and spontaneous cerebrospinal fluid leaks, involve the vessels not of the brain itself, but of the outer fibrous membrane of the brain, the dura mater (DM. The pathogenesis of these disorders remains mysterious and how estrogen regulates structural and functional integrity of DM vasculature is largely unknown. Here, we demonstrate that post ovariectomy (OVX DM vascular remodeling is manifested by microvessel destabilization, capillary rarefaction, increased vascular permeability, and aberrant angio-architecture, and is the result of disrupted E2-regulated PDGF-BB signaling within dura microvasculature. These changes, associated with the reduction in systemic PDGF-BB levels, are not corrected by a flat-dose E2 hormone replacement therapy (HRT, but are largely prevented using HRT schedules mimicking physiological E2 fluctuations. We demonstrate that 1 E2 regulates PDGF-BB production by endothelial cells in a dose-dependent manner and 2 optimization of PDGF-BB levels and induction of robust PDGF-mediated endothelial cell-vascular pericyte interactions require high (estrous E2 concentrations. We conclude that high (estrous levels of E2 are important in controlling PDGF-mediated crosstalk between endothelial cells and pericytes, a fundamental mechanism governing microvessel stability and essential for preserving intracranial homeostasis.

Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard.

Science.gov (United States)

van Vuuren, B Jansen; Bergseth, G; Mollnes, T E; Shaw, A M

2014-01-15

Electroluminescent assays for epitopes on the complement components C3dg, terminal complement complex (TCC) and factor B/Bb (fB/Bb) have been developed with capture and detection antibodies to produce detection limits C3dg=91±9ng/mL, TCC=3±0.1ng/mL and fB=55.7±0.1ng/mL. The assay performance was assessed against a series of zymosan and heat aggregated IgG (HAIgG) in vitro activations of complement using a calibrated activated complement serum (ACS) as calibration standard. The ACS standard was stable within 20% accuracy over a 6-month period with freeze-thaw cycles as required. Differential activation of the complement cascade was observed for TCC showing a pseudo-first order formation half-life of 3.5h after activation with zymosan. The C3dg activation fragment indicates a 10% total activation for both activation agents. The kinetic-epitope analysis for fB indicates that the capture epitope is on the fB/Bb protein fragment which can then become covered by the formation of C3bBb or C3bBbP complexes during the time course of the cascade. Copyright © 2013 Elsevier B.V. All rights reserved.

Rotavirus specific maternal antibodies and immune response to RV3-BB neonatal rotavirus vaccine in New Zealand

Science.gov (United States)

Chen, Mee-Yew; Kirkwood, Carl D.; Bines, Julie; Cowley, Daniel; Pavlic, Daniel; Lee, Katherine J.; Orsini, Francesca; Watts, Emma; Barnes, Graeme; Danchin, Margaret

2017-01-01

ABSTRACT Background: Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccines observed in children in developing countries. This study aimed to investigate the effect of rotavirus specific maternal antibodies on the serum IgA response or stool excretion of vaccine virus after any dose of an oral rotavirus vaccine, RV3-BB, in parallel to a Phase IIa clinical trial conducted at Dunedin Hospital, New Zealand. At the time of the study rotavirus vaccines had not been introduced in New Zealand and the burden of rotavirus disease was evident. Methods: Rotavirus specific IgG and serum neutralizing antibody (SNA) levels in cord blood and IgA levels in colostrum and breast milk samples collected ∼4 weeks, ∼20 weeks and ∼28 weeks after birth were measured. Infants were randomized to receive the first dose of vaccine at 0–5 d (neonatal schedule) or 8 weeks (infant schedule). Breast feeding was with-held for 30 minutes before and after vaccine administration. The relationship between rotavirus specific IgG and SNA levels in cord blood and IgA in colostrum and breast milk at the time of first active dose of RV3-BB vaccine and level of IgA response and stool excretion after 3 doses of vaccine was assessed using linear and logistic regression. Results: Forty infants received 3 doses of RV3-BB rotavirus vaccine and were included in the analysis of the neonatal and infant groups. Rotavirus specific IgA in colostrum (neonatal schedule group) and breast milk at 4 weeks (infant schedule group) was identified in 14/21 (67%) and 14/17 (82%) of infants respectively. There was little evidence of an association between IgA in colostrum or breast milk IgA at 4 weeks, or between cord IgG or SNA level, and IgA response or stool excretion after 3 doses of RV3-BB, or after one dose (neonatal schedule) (all p>0.05). Conclusions: The level of IgA in colostrum or breast milk and level of placental Ig

Rotavirus specific maternal antibodies and immune response to RV3-BB neonatal rotavirus vaccine in New Zealand.

Science.gov (United States)

Chen, Mee-Yew; Kirkwood, Carl D; Bines, Julie; Cowley, Daniel; Pavlic, Daniel; Lee, Katherine J; Orsini, Francesca; Watts, Emma; Barnes, Graeme; Danchin, Margaret

2017-05-04

Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccines observed in children in developing countries. This study aimed to investigate the effect of rotavirus specific maternal antibodies on the serum IgA response or stool excretion of vaccine virus after any dose of an oral rotavirus vaccine, RV3-BB, in parallel to a Phase IIa clinical trial conducted at Dunedin Hospital, New Zealand. At the time of the study rotavirus vaccines had not been introduced in New Zealand and the burden of rotavirus disease was evident. Rotavirus specific IgG and serum neutralizing antibody (SNA) levels in cord blood and IgA levels in colostrum and breast milk samples collected ∼4 weeks, ∼20 weeks and ∼28 weeks after birth were measured. Infants were randomized to receive the first dose of vaccine at 0-5 d (neonatal schedule) or 8 weeks (infant schedule). Breast feeding was with-held for 30 minutes before and after vaccine administration. The relationship between rotavirus specific IgG and SNA levels in cord blood and IgA in colostrum and breast milk at the time of first active dose of RV3-BB vaccine and level of IgA response and stool excretion after 3 doses of vaccine was assessed using linear and logistic regression. Forty infants received 3 doses of RV3-BB rotavirus vaccine and were included in the analysis of the neonatal and infant groups. Rotavirus specific IgA in colostrum (neonatal schedule group) and breast milk at 4 weeks (infant schedule group) was identified in 14/21 (67%) and 14/17 (82%) of infants respectively. There was little evidence of an association between IgA in colostrum or breast milk IgA at 4 weeks, or between cord IgG or SNA level, and IgA response or stool excretion after 3 doses of RV3-BB, or after one dose (neonatal schedule) (all p>0.05). The level of IgA in colostrum or breast milk and level of placental IgG and SNA did not impact on the serum IgA response or

Reducing the devastating effects of cataclysmic events: Cooperation

International Nuclear Information System (INIS)

Jing Ding; Fong, P.

1989-01-01

Natural calamities, including earthquakes, land sinkings, volcanos, floods, tsunamis, hurricanes, avalanches, lightnings, forest fires, are discussed. Their devastating effects can be alleviated by cooperative efforts, sometimes international, among all concerned. The successful earthquake management of the Haicheng event is discussed as an example. Now the authors have environmental calamities, including erosion floods, dam failures, acid rain, ozone depletion, and the global greenhouse effect. There are empirical and theoretical questions about whether the greenhouse effect leads to global warming or polar ice melting. The warming prediction was based on model calculation with an incorrect boundary condition. When corrected with the right boundary condition, the models predict ice melting. The same is borne out in independent static and dynamic theories. Thus, there will be no greenhouse warming, only a sea level rise of up to 200 feet, which is much worse. The only way out is replacing fossil fuels by nuclear power. The nuclear fear is analyzed in terms of the Don Quixote syndrome and Laplace dictum. The lessons of Three Mile Island and Chernobyl actually strengthen the case of nuclear safety. New reactor technology and design will make it even safer. After 250 years of studying the history of the earth, geologists are now able to show that it is nothing but a long series of gradual changes and violent events. What was true in the past will remain so in the future, and cataclysms will occur again and again. Earthquakes, land subsidence and volcanic eruptions; flood and drought; the tsunami, tropical cyclones and avalanches; lightning and forest fires; have occurred ever since mountains, oceans, rivers, atmosphere, and ice sheets have been on the earth, and they will continue to happen

Exposure of a distinct PDCA-1+ (CD317 B cell population to agonistic anti-4-1BB (CD137 inhibits T and B cell responses both in vitro and in vivo.

Directory of Open Access Journals (Sweden)

Dass S Vinay

Full Text Available 4-1BB (CD137 is an important T cell activating molecule. Here we report that it also promotes development of a distinct B cell subpopulation co-expressing PDCA-1. 4-1BB is expressed constitutively, and its expression is increased when PDCA-1(+ B cells are activated. We found that despite a high level of surface expression of 4-1BB on PDCA-1(+ B cells, treatment of these cells with agonistic anti-4-1BB mAb stimulated the expression of only a few activation markers (B7-2, MHC II, PD-L2, cytokines (IL-12p40/p70, and chemokines (MCP-1, RANTES, as well as sTNFR1, and the immunosuppressive enzyme, IDO. Although the PDCA-1(+ B cells stimulated by anti-4-1BB expressed MHC II at high levels and took up antigens efficiently, Ig class switching was inhibited when they were pulsed with T-independent (TI or T-dependent (TD Ags and adoptively transferred into syngeneic recipients. Furthermore, when anti-4-1BB-treated PDCA-1(+ B cells were pulsed with OVA peptide and combined with Vα2(+CD4(+ T cells, Ag-specific cell division was inhibited both in vitro and in vivo. Our findings suggest that the 4-1BB signal transforms PDCA-1(+ B cells into propagators of negative immune regulation, and establish an important role for 4-1BB in PDCA-1(+ B cell development and function.

Pengaruh Quality of Work Life terhadap Kinerja Perawat Pelaksana di Rumah Sakit Tk II Putri Hijau Kesdam I/BB Medan

OpenAIRE

Pratama, Muchti Yuda

2012-01-01

Quality of work life is a problem which should have been paid attention by the management of Level II Putri Hijau Hospital Kesdam I/BB Medan because quality of work life is regarded as being able to improve the participation and contribution of the nurses working here to this hospital. The purpose of this analytical survey study with cross-sectional design conducted at Level II Putri Hijau Hospital Kesdam I/BB Medan was to analyze the influence of quality of work life including employees’ ...

Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis

Directory of Open Access Journals (Sweden)

Xingqi Wang

2016-05-01

Full Text Available PDGF-BB/PDGFR-ββ signaling plays very crucial roles in the process of many diseases such as liver fibrosis. However, drug candidates with selective affinities for PDGF-B/PDGFR-β remain deficient. Here, we identified a natural cyclopeptide termed destruxin A5 that effectively inhibits PDGF-BB-induced PDGFR-β signaling. Interestingly and importantly, the inhibitory mechanism is distinct from the mechanism of tyrosine kinase inhibitors because destruxin A5 does not have the ability to bind to the ATP-binding pocket of PDGFR-β. Using Biacore T200 technology, thermal shift technology, microscale thermophoresis technology and computational analysis, we confirmed that destruxin A5 selectively targets the PDGF-B/PDGFR-β interaction interface to block this signaling. Additionally, the inhibitory effect of destruxin A5 on PDGF-BB/PDGFR-ββ signaling was verified using in vitro, ex vivo and in vivo models, in which the extent of liver fibrosis was effectively alleviated by destruxin A5. In summary, destruxin A5 may represent an efficacious and more selective inhibitor of PDGF-BB/PDGFR-ββ signaling.

Radiative Transfer Through Discs of Cataclysmic Variables

Czech Academy of Sciences Publication Activity Database

Korčáková, Daniela; Nagel, T.; Werner, K.; Suleimanov, V.; Votruba, Viktor

2010-01-01

Roč. 1273, - (2010), s. 350-353 ISSN 1551-7616. [European White Dwarf Workshop /17./. Tübingen, 16.08.2010-20.08.2010] R&D Projects: GA ČR GP205/09/P476 Institutional research plan: CEZ:AV0Z10030501 Keywords : radiative transfer * Doppler effect, * accretion disks Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

Brown dwarfs in retrogradely precessing cataclysmic variables?

Directory of Open Access Journals (Sweden)

Martin E.L.

2011-07-01

Full Text Available We compare Smoothed Particle Hydrodynamic simulations of retrogradely precessing accretion disks that have a white dwarf primary and a main sequence secondary with observational data and with theory on retrograde precession via tidal torques like those by the Moon and the Sun on the Earth [1, 2]. Assuming the primary does not accrete much of the mass lost from the secondary, we identify the theoretical low mass star/brown dwarf boundary. We find no observational candidates in our study that could qualify as brown dwarfs.

Impact of Cry3Bb1-expressing Bt maize on adults of the western corn rootworm, Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae).

Science.gov (United States)

Meissle, Michael; Hellmich, Richard L; Romeis, Jörg

2011-07-01

Genetically engineered maize producing insecticidal Cry3Bb1 protein from Bacillus thuringiensis (Bt) is protected from root damage by corn rootworm larvae. An examination was made to establish whether western corn rootworm (Diabrotica virgifera virgifera) adults are affected by Cry3Bb1-expressing maize (MON88017) when feeding on above-ground tissue. In laboratory bioassays, adult D. v. virgifera were fed for 7 weeks with silk, leaves or pollen from Bt maize or the corresponding near-isoline. Male, but not female, survival was reduced in the Bt-leaf treatment compared with the control. Female weight was lower when fed Bt maize, and egg production was reduced in the Bt-silk treatment. ELISA measurements demonstrated that beetles feeding on silk were exposed to higher Cry3Bb1 concentrations than beetles collected from Bt-maize fields in the United States. In contrast to silk and pollen, feeding on leaves resulted in high mortality and low fecundity. Females feeding on pollen produced more eggs than on silk. C:N ratios indicated that silk does not provide enough nitrogen for optimal egg production. Direct effects of Cry3Bb1 on adult beetles could explain the observed effects, but varietal differences between Bt and control maize are also possible. The impact of Bt maize on adult populations, however, is likely to be limited. Copyright © 2011 Society of Chemical Industry.

Prototypic implementations of the building block for component based open Hypermedia systems (BB/CB-OHSs)

DEFF Research Database (Denmark)

Mohamed, Omer I. Eldai

2005-01-01

In this paper we describe the prototypic implementations of the BuildingBlock (BB/CB-OHSs) that proposed to address some of the Component-based Open Hypermedia Systems (CB-OHSs) issues, including distribution and interoperability [4, 11, 12]. Four service implementations were described below. The...

A recombination outside the BB deletion refines the location of the X-linked retinitis pigmentosa locus RP3

Energy Technology Data Exchange (ETDEWEB)

Fujita, R.; Bingham, E.; Forsythe, P.; McHenry, C. [Univ. of Michigan, Ann Arbor, MI (United States)] [and others

1996-07-01

Genetic loci for X-linked retinitis pigmentosa (XLRP) have been mapped between Xp11.22 and Xp22.13 (RP2, RP3, RP6, and RP15). The RP3 gene, which is responsible for the predominant form of XLRP in most Caucasian populations, has been localized to Xp21.1 by linkage analysis and the map positions of chromosomal deletions associated with the disease. Previous linkage studies have suggested that RP3 is flanked by the markers DXS1110 (distal) and OTC (proximal). Patient BB was though to have RP because of a lesion at the RP3 locus, in addition to chronic granulomatous disease, Duchenne muscular dystrophy (DMD), mild mental retardation, and the McLeod phenotype. This patient carried a deletion extending {approximately}3 Mb from DMD in Xp21.3 to Xp21.1, with the proximal breakpoint located {approximately}40 kb centromeric to DXS1110. The RP3 gene, therefore, is believed to reside between DXS1110 and the proximal breakpoint of the BB deletion. In order to refine the location of RP3 and to ascertain patients with RP3, we have been analyzing several XLRP families for linkage to Xp markers. Linkage analysis in an American family of 27 individuals demonstrates segregation of XLRP with markers in Xp21.1, consistent with the RP3 subtype. One affected male shows a recombination event proximal to DXS1110. Additional markers within the DXS1110-OTC interval show that the crossover is between two novel polymorphic markers, DXS8349 and M6, both of which are present in BB DNA and lie centromeric to the proximal breakpoint. This recombination places the XLRP mutation in this family outside the BB deletion and redefines the location of RP3. 22 refs., 3 figs., 2 tabs.

Daily low-dose/continuous capecitabine combined with neo-adjuvant irradiation reduces VEGF and PDGF-BB levels in rectal carcinoma patients

International Nuclear Information System (INIS)

Loven, David; B e'Ery, Einat; Yerushalmi, Rinat; Koren, Claude; Sulkes, Aaron; Fenig, Eyal; Lavi, Idit; Shaked, Yuval

2008-01-01

Metronomic low-dose chemotherapy regimen was found to have an antiangiogenic effect in tumors. However, its effect on levels of circulating pro-angiogenic and anti-angiogenic factors is not fully explored. Materials and methods. The levels of both VEGF and PDGF-BB were measured in three time points, in the serum of 32 rectal carcinoma patients receiving daily reduced-dose/continuous capecitabine in combination with preoperative pelvic irradiation. Results. We found a significant decrease in VEGF and PDGF-BB serum levels during the combination treatment (p<0.0001), followed by an increase in the successive rest-period (p<0.0001). In addition, substantial changes in platelets counts were observed during treatment in correlation with the changes of VEGF and PDGF-BB serum levels. Discussion. These results suggest that combined chemo-irradiation affect levels of pro-angiogenic factors during treatment, and may reflect an anti-angiogenic window induced during this treatment. The potential implications of this inducible phenomenon, including a possible clinical benefit from the administration of long lasting metronomic chemotherapy immediately following combined chemo-irradiation, would warrant further investigation

Identification of Hard X-ray Sources in Galactic Globular Clusters: Simbol-X Simulations

Science.gov (United States)

Servillat, M.

2009-05-01

Globular clusters harbour an excess of X-ray sources compared to the number of X-ray sources in the Galactic plane. It has been proposed that many of these X-ray sources are cataclysmic variables that have an intermediate magnetic field, i.e. intermediate polars, which remains to be confirmed and understood. We present here several methods to identify intermediate polars in globular clusters from multiwavelength analysis. First, we report on XMM-Newton, Chandra and HST observations of the very dense Galactic globular cluster NGC 2808. By comparing UV and X-ray properties of the cataclysmic variable candidates, the fraction of intermediate polars in this cluster can be estimated. We also present the optical spectra of two cataclysmic variables in the globular cluster M 22. The HeII (4868 Å) emission line in these spectra could be related to the presence of a magnetic field in these objects. Simulations of Simbol-X observations indicate that the angular resolution is sufficient to study X-ray sources in the core of close, less dense globular clusters, such as M 22. The sensitivity of Simbol-X in an extended energy band up to 80 keV will allow us to discriminate between hard X-ray sources (such as magnetic cataclysmic variables) and soft X-ray sources (such as chromospherically active binaries).

Rapid oscillations in cataclysmic variables. III. An oblique rotator in AE aquarii

International Nuclear Information System (INIS)

Patternson, J.

1979-01-01

A rapid, strictly periodic oscillation has been discovered in the light curve of the novalike variable AE Aquarii. The fundamental period is 33.076737 s, with comparable power at the first harmonic. The amplitude averages 0.2--0.3% but can exceed 1% in flares. Pulse timings around the binary orbit prove that the periodicity arises in the white dwarf, and lead to an accurate measurement of the projected orbital velocity. The velocity curve and other constraints lead to a mass determination for the component stars :0.74 +- 0.06 M/sub sun/ for the late-type star and 0.94 +- 0.10 M/sub sun/ for the white dwarf. Estimates are also given for the system dimensions, luminosity, distance, and mass transfer rate.Quasi-periodic oscillations are also detected in flares, and have periods near the coherent periods of 16.5 and 33 s. Their characteristics suggest an origin in gaseous blobs produced by instabilities near the inner edge of the accretion disk.A model is presented in which the strict periodicity arises from the rotation of an accreting, magnetized white dwarf, with a surface field of 10 6 --10 7 gauss. Future spectroscopic, polarimetric, and X-ray observations should provide critical tests for predictions of the model

DISCOVERY OF A WOLF-RAYET STAR THROUGH DETECTION OF ITS PHOTOMETRIC VARIABILITY

Energy Technology Data Exchange (ETDEWEB)

Littlefield, Colin [Law School, University of Notre Dame, Notre Dame, IN 46556 (United States); Garnavich, Peter; McClelland, Colin; Rettig, Terrence [Physics Department, University of Notre Dame, Notre Dame, IN 46556 (United States); Marion, G. H. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Vinko, Jozsef [Department of Optics, University of Szeged (Hungary); Wheeler, J. Craig [Astronomy Department, University of Texas, Austin, TX 78712 (United States)

2012-06-15

We report the serendipitous discovery of a heavily reddened Wolf-Rayet star that we name WR 142b. While photometrically monitoring a cataclysmic variable, we detected weak variability in a nearby field star. Low-resolution spectroscopy revealed a strong emission line at 7100 A, suggesting an unusual object and prompting further study. A spectrum taken with the Hobby-Eberly Telescope confirms strong He II emission and an N IV 7112 A line consistent with a nitrogen-rich Wolf-Rayet star of spectral class WN6. Analysis of the He II line strengths reveals no detectable hydrogen in WR 142b. A blue-sensitive spectrum obtained with the Large Binocular Telescope shows no evidence for a hot companion star. The continuum shape and emission line ratios imply a reddening of E(B - V) = 2.2-2.6 mag. We estimate that the distance to WR 142b is 1.4 {+-} 0.3 kpc.

DISCOVERY OF A WOLF-RAYET STAR THROUGH DETECTION OF ITS PHOTOMETRIC VARIABILITY

International Nuclear Information System (INIS)

Littlefield, Colin; Garnavich, Peter; McClelland, Colin; Rettig, Terrence; Marion, G. H.; Vinkó, József; Wheeler, J. Craig

2012-01-01

We report the serendipitous discovery of a heavily reddened Wolf-Rayet star that we name WR 142b. While photometrically monitoring a cataclysmic variable, we detected weak variability in a nearby field star. Low-resolution spectroscopy revealed a strong emission line at 7100 Å, suggesting an unusual object and prompting further study. A spectrum taken with the Hobby-Eberly Telescope confirms strong He II emission and an N IV 7112 Å line consistent with a nitrogen-rich Wolf-Rayet star of spectral class WN6. Analysis of the He II line strengths reveals no detectable hydrogen in WR 142b. A blue-sensitive spectrum obtained with the Large Binocular Telescope shows no evidence for a hot companion star. The continuum shape and emission line ratios imply a reddening of E(B – V) = 2.2-2.6 mag. We estimate that the distance to WR 142b is 1.4 ± 0.3 kpc.

Observability of B0 - B vector0 mixing in the e+e- → BB vector X reaction at √s approx. = 15 - 30 GeV

International Nuclear Information System (INIS)

Fridman, A.; Schwarz, A.

1985-01-01

The possibility of observing mixing in the B 0 B vector B 0 system has been rather widely discussed. In particular theoretical estimates have been made for the case of B 0 B vector 0 production in the e + e - → upsilon (4S) → B 0 B vector 0 reaction. Mixing in this specific channel is expected to appear as a small effect and might thus be hardly measurable. Here the authors will therefore consider the e + e - → BB vector X reaction (X meaning anything well above the BB vector threshold where any combination of BB vector mesons (B/sub u/B vector/sub u/, B/sub u/B vector/sub d/, B/sub u/B vector/sub s/, etc.) can be produced. This reaction might be advantageous as mixing is expected to be almost complete for the B/sub s/ mesons. In this respect the study of mixing effects in the e + e - → BB vector X reaction is complementary to that in the e + e - → upsilon (4S) → B/sub d/ 0 B vector /sub e/ 0 process. In Section B.2 the authors recall briefly the parameters used to describe the BB vector mixing and in Section B.3 they give estimates for the mixing effects which could be observed in the e + e - → BB vector X reaction as well as in the upsilon (4S) decays. The authors have also evaluated the influence of a non-spectator component in the B-decay on the observability of the mixing phenomenon. Finally, in Section B.4 they give estimates for the number of signal and background events which could be observed in an e + e - experiment with an accumulated luminosity of 1000 pb -1 . 33 references, 4 figures

Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+ melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy.

Directory of Open Access Journals (Sweden)

Jessica Ann Chacon

Full Text Available Adoptive T-cell therapy (ACT using tumor-infiltrating lymphocytes (TIL can induce tumor regression in up to 50% or more of patients with unresectable metastatic melanoma. However, current methods to expand melanoma TIL, especially the "rapid expansion protocol" (REP were not designed to enhance the generation of optimal effector-memory CD8(+ T cells for infusion. One approach to this problem is to manipulate specific co-stimulatory signaling pathways to enhance CD8(+ effector-memory T-cell expansion. In this study, we determined the effects of activating the TNF-R family member 4-1BB/CD137, specifically induced in activated CD8(+ T cells, on the yield, phenotype, and functional activity of expanded CD8(+ T cells during the REP. We found that CD8(+ TIL up-regulate 4-1BB expression early during the REP after initial TCR stimulation, but neither the PBMC feeder cells in the REP or the activated TIL expressed 4-1BB ligand. However, addition of an exogenous agonistic anti-4-1BB IgG4 (BMS 663513 to the REP significantly enhanced the frequency and total yield of CD8(+ T cells as well as their maintenance of CD28 and increased their anti-tumor CTL activity. Gene expression analysis found an increase in bcl-2 and survivin expression induced by 4-1BB that was associated with an enhanced survival capability of CD8(+ post-REP TIL when re-cultured in the absence or presence of cytokines. Our findings suggest that adding an agonistic anti-4-1BB antibody during the time of TIL REP initiation produces a CD8(+ T cell population capable of improved effector function and survival. This may greatly improve TIL persistence and anti-tumor activity in vivo after adoptive transfer into patients.

Serial measurements of serum PDGF-AA, PDGF-BB, FGF2, and VEGF in multiresistant ovarian cancer patients treated with bevacizumab

Directory of Open Access Journals (Sweden)

Madsen Christine

2012-09-01

Full Text Available Abstract Introduction Anti-VEGF treatment has proven effective in recurrent ovarian cancer. However, the identification of the patients most likely to respond is still pending. It is well known that the angiogenesis is regulated by several other pro-angiogenic proteins, e.g. the platelet - derived growth factor (PDGF system and the fibroblast growth factor (FGF system. These other signaling pathways may remain active or become upregulated during anti-VEGF treatment. The aim of the present study was to investigate if potential changes of PDGF-BB, PDGF-AA, and FGF2 before and during bevacizumab treatment had predictive value for early progression or survival. Furthermore, we wanted to investigate the importance of serum VEGF in the same cohort. Methods This study included 106 patients with chemotherapy-resistant epithelial ovarian cancer who were treated with single agent bevacizumab as part of a biomarker protocol. Patients were evaluated for response by the Response Evaluation Criteria In Solid Tumors (RECIST and/ or Gynecologic Cancer Intergroup (GCIG CA125 criteria. Serum samples were collected at baseline and prior to each treatment. FGF2, PDGF-BB, PDGF-AA were quantified simultaneously using the Luminex system, and VEGF-A was measured by ELISA. Eighty-eight baseline samples were avaliable for FGF2, PDGF-BB, PDGF-AA analysis, and 93 baseline samples for VEGF. Results High baseline serum VEGF was related to poor overall survival. Furthermore, high serum PDGF-BB and FGF2 was of prognostic significance. None of the markers showed predictive value, neither at baseline level nor during the treatment.

Matched predictions for the bb̄H cross section at the 13 TeV LHC

International Nuclear Information System (INIS)

Bonvini, Marco; Papanastasiou, Andrew S.; Tackmann, Frank J.

2016-01-01

We present up-to-date matched predictions for the bb̄H inclusive cross section at the LHC at √s=13 TeV. Using a previously developed method, our predictions consistently combine the complete NLO contributions that are present in the 4-flavor scheme calculation, including finite b-quark mass effects as well as top-loop induced Y_bY_t interference contributions, with the resummation of collinear logarithms of m_b/m_H as present in the 5-flavor scheme calculation up to NNLO. We provide a detailed estimate of the perturbative uncertainties of the matched result by examining its dependence on the factorization and renormalization scales, the scale of the Yukawa coupling, and also the low b-quark matching scale in the PDFs. We motivate the use of a central renormalization scale of m_H/2, which is halfway between the values typically chosen in the 4-flavor and 5-flavor scheme calculations. We evaluate the parametric uncertainties due to the PDFs and the b-quark mass, and in particular discuss how to systematically disentangle the parametric m_b dependence and the unphysical b-quark matching scale dependence. Our best prediction for the bb̄H production cross section in the Standard Model at 13 TeV and for m_H=125 GeV is σ(bb̄H)=0.52 pb [1±9.6%(perturbative) _−_3_._6_%"+"2"."9"%(parametric)]. We also provide predictions for a range of Higgs masses m_H∈[50,750] GeV. Our method to compute the matched prediction and to evaluate its uncertainty can be readily applied to other heavy-quark-initiated processes at the LHC.

THE TIME DOMAIN SPECTROSCOPIC SURVEY: VARIABLE SELECTION AND ANTICIPATED RESULTS

Energy Technology Data Exchange (ETDEWEB)

Morganson, Eric; Green, Paul J. [Harvard Smithsonian Center for Astrophysics, 60 Garden St, Cambridge, MA 02138 (United States); Anderson, Scott F.; Ruan, John J. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Myers, Adam D. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Eracleous, Michael; Brandt, William Nielsen [Department of Astronomy and Astrophysics, 525 Davey Laboratory, The Pennsylvania State University, University Park, PA 16802 (United States); Kelly, Brandon [Department of Physics, Broida Hall, University of California, Santa Barbara, CA 93106-9530 (United States); Badenes, Carlos [Department of Physics and Astronomy and Pittsburgh Particle Physics, Astrophysics and Cosmology Center (PITT PACC), University of Pittsburgh, 3941 O’Hara St, Pittsburgh, PA 15260 (United States); Bañados, Eduardo [Max-Planck-Institut für Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany); Blanton, Michael R. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Bershady, Matthew A. [Department of Astronomy, University of Wisconsin, 475 N. Charter St., Madison, WI 53706 (United States); Borissova, Jura [Instituto de Física y Astronomía, Universidad de Valparaíso, Av. Gran Bretaña 1111, Playa Ancha, Casilla 5030, and Millennium Institute of Astrophysics (MAS), Santiago (Chile); Burgett, William S. [GMTO Corp, Suite 300, 251 S. Lake Ave, Pasadena, CA 91101 (United States); Chambers, Kenneth, E-mail: emorganson@cfa.harvard.edu [Institute for Astronomy, University of Hawaii at Manoa, Honolulu, HI 96822 (United States); and others

2015-06-20

We present the selection algorithm and anticipated results for the Time Domain Spectroscopic Survey (TDSS). TDSS is an Sloan Digital Sky Survey (SDSS)-IV Extended Baryon Oscillation Spectroscopic Survey (eBOSS) subproject that will provide initial identification spectra of approximately 220,000 luminosity-variable objects (variable stars and active galactic nuclei across 7500 deg{sup 2} selected from a combination of SDSS and multi-epoch Pan-STARRS1 photometry. TDSS will be the largest spectroscopic survey to explicitly target variable objects, avoiding pre-selection on the basis of colors or detailed modeling of specific variability characteristics. Kernel Density Estimate analysis of our target population performed on SDSS Stripe 82 data suggests our target sample will be 95% pure (meaning 95% of objects we select have genuine luminosity variability of a few magnitudes or more). Our final spectroscopic sample will contain roughly 135,000 quasars and 85,000 stellar variables, approximately 4000 of which will be RR Lyrae stars which may be used as outer Milky Way probes. The variability-selected quasar population has a smoother redshift distribution than a color-selected sample, and variability measurements similar to those we develop here may be used to make more uniform quasar samples in large surveys. The stellar variable targets are distributed fairly uniformly across color space, indicating that TDSS will obtain spectra for a wide variety of stellar variables including pulsating variables, stars with significant chromospheric activity, cataclysmic variables, and eclipsing binaries. TDSS will serve as a pathfinder mission to identify and characterize the multitude of variable objects that will be detected photometrically in even larger variability surveys such as Large Synoptic Survey Telescope.

Growth and adhesion to HT-29 cells inhibition of Gram-negatives by Bifidobacterium longum BB536 e Lactobacillus rhamnosus HN001 alone and in combination.

Science.gov (United States)

Inturri, R; Stivala, A; Furneri, P M; Blandino, G

2016-12-01

The aim of this study was to test the inhibitory effect of supernatants of broth cultures of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001, both individually and in combination, against Gram-negative strains (uropathogens, enteropathogens and a reference strain). Moreover, in vitro protection of B. longum BB536 and L. rhamnosus HN001, both individually and in combination, against pathogen adhesion to HT-29 cell line, was investigated. The inhibitory activity was performed by the agar diffusion test and in vitro antagonistic activity against pathogen adhesion to human epithelial intestinal HT-29 cells was performed using standardized culture techniques. The study showed that B. longum BB536 and L. rhamnosus HN001, individually and in combination have inhibitory activity against the majority of the Gram negative strains tested. Furthermore, the results showed that both probiotic strains have a good capacity to inhibit pathogenic adhesion to HT-29 cells. Moreover, the ability of B. longum BB536 and L. rhamnosus HN001 to inhibit pathogenic adhesion increased when they were used in combination. The combination of B. longum BB536 and L. rhamnosus HN001 showed inhibitory activity against Gram-negatives and an improved ability to reduce their adhesion properties and to compete with them. The simultaneous presence of the two-probiotic strains could promote competitive mechanisms able to reduce the adhesion properties of pathogen strains and have an important ecological role within the highly competitive environment of the human gut.

Effect of PDGF-BB and beta-tricalcium phosphate (β-TCP) on bone formation around dental implants: a pilot study in sheep.

Science.gov (United States)

Choo, Tina; Marino, Victor; Bartold, P Mark

2013-02-01

The aim of this investigation was to examine the effect of a combination of purified recombinant human platelet-derived growth factor (rhPDGF-BB) mixed with a synthetic beta-tricalcium phosphate (β-TCP) on bone healing around dental implants with critical size circumferential defects. Three critical size circumferential defects were prepared in the ilium of six sheep. Three dental implants were placed into the centre of each defect and the 3.25 mm circumferential gap was filled with (a) blood clot alone; (b) β-TCP; (c) rhPDGF-BB (0.3 mg/ml) with β-TCP. All the defects in each group were covered with a Bio-Gide(®) resorbable barrier membrane. The sheep were sacrificed at 2 and 4 weeks and histological and histomorphometric analyses were performed to determine the percentage of new mineralized bone formation and residual β-TCP graft particles in the defects. Defects filled with rhPDGF-BB/β-TCP showed the highest rate of bone formation after 2 and 4 weeks with limited degradation of the β-TCP particles over 4 weeks. Defects filled with β-TCP showed the least bone fill after 2 and 4 weeks, and faster degradation of the β-TCP particles over 4 weeks compared with defects filled with rhPDGF-BB/β-TCP. Percentage of new mineralized bone was comparable in defects to blood clot alone and β-TCP after 4 weeks of healing, but there was a collapse in the defect area in defects with blood clot alone. In comparison, the space was maintained when β-TCP was used in defects at 4 weeks. Defects which had β-TCP alone showed an inhibition in bone healing at 2 and 4 weeks; however, the combination of rhPDGF-BB with β-TCP enhanced bone regeneration in these peri-implant bone defects at the same time intervals. © 2011 John Wiley & Sons A/S.

Development of a Mailing List on Variable Stars, VSNET

Science.gov (United States)

Nogami, D.; Kato, T.; Baba, H.; Kunjaya, C.

Various usages of the Internet have been developed and made remarkable progress these years, which is now dramatically changing the style of astronomical study. Among those, the maing list is thought to be most useful to study of unpredictable objects for the characteristics, especially rapidness and equality. We started a mailing list (VSNET) on variable stars, mainly on cataclysmic variables and supernovae, in 1994 July for mutual exchange of information and ideas between astronomers including professionals and amateurs. Up to now, the various articles have been distributed, for example, calls for follow up observations of transient objects discovered in the UV or X-ray region, calls for ground-based observations simultaneous with ones by the space telescopes, discoveries of supernovae, alert notices of outbursts in long dormant dwarf novae (EG Cnc, AL Com, UZ Boo, HT Cas, etc), and so on. You can get long-term light curves of variable stars drawn using VSNET data on the VSNET web pages http://www.kusastro.kyoto-u.ac.jp/vsnet/. The archives of VSNET mails are available via VSNET web pages and anonymous ftp ftp://ftp.kusastro.kyoto-u.ac.jp/pub/vsnet/Mail/. If you have any questions and suggestions on VSNET, please feel free to contact us (vsnet-adm@kusastro.kyoto-u.ac.jp).

MRI of intracranial vertebral artery dissection: evaluation of intramural haematoma using a black blood, variable-flip-angle 3D turbo spin-echo sequence

Energy Technology Data Exchange (ETDEWEB)

Takano, Koichi; Yamashita, Shinnichi; Kuwabara, Yasuo; Yoshimitsu, Kengo [Fukuoka University, Department of Radiology, Faculty of Medicine, Fukuoka-shi, Fukuoka (Japan); Takemoto, Koichiro; Inoue, Tooru [Fukuoka University, Department of Neurosurgery, Faculty of Medicine, Fukuoka (Japan)

2013-07-15

We investigated the efficacy of three-dimensional black blood T1-weighted imaging (3D-BB-T1WI) using a variable refocusing flip angle turbo spin-echo sequence in the diagnosis of intracranial vertebral artery dissection (VAD). Sixteen consecutive patients diagnosed with intracranial VAD underwent magnetic resonance imaging that included 3D time-of-flight-MRA, axial spin-echo T1-weighted images (SE-T1WI) and oblique coronal 3D-BB-T1WI sequences. The visualization, morphology and extent of intramural haematomas were assessed and compared among the sequences. Results obtained by digital subtraction angiography (DSA), 3D-angiography and/or 3D-CT angiography (CTA) were used as standards of reference. 3D-BB-T1WI revealed intramural haematomas in all cases, whereas SE-T1WI and magnetic resonance angiography (MRA) failed to reveal a haematoma in one case and three cases, respectively. The mean visualization grading score for the intramural haematoma was the highest for 3D-BB-T1WI, and there was a statistically significant difference among the sequences (p < 0.001). At least a portion of the intramural haematoma was distinguishable from the lumen on 3D-BB-T1WI, whereas the haematomas were entirely indistinguishable from intraluminal signals on MRA in two cases (12.5 %) and on SE-T1WI in one case (6.3 %). 3D-BB-T1WI revealed the characteristic crescent shape of the intramural haematoma in 14 cases (87.5 %), whereas SE-T1WI and MRA revealed a crescent shape in only 7 cases (43.8 %) and 8 cases (50 %), respectively. In a consensus reading, 3D-BB-T1WI was considered the most consistent sequence in representing the extent and morphology of the lesion in 14 cases (87.5 %), compared to DSA and CTA. 3D-BB-T1WI is a promising method to evaluate intramural haematoma in patients with suspected intracranial VAD. (orig.)

Mating Success, Longevity, and Fertility of Diabrotica virgifera virgifera LeConte (Chrysomelidae: Coleoptera in Relation to Body Size and Cry3Bb1-Resistant and Cry3Bb1-Susceptible Genotypes

Directory of Open Access Journals (Sweden)

Bryan Wade French

2015-11-01

Full Text Available Insect resistance to population control methodologies is a widespread problem. The development of effective resistance management programs is often dependent on detailed knowledge regarding the biology of individual species and changes in that biology associated with resistance evolution. This study examined the reproductive behavior and biology of western corn rootworm beetles of known body size from lines resistant and susceptible to the Cry3Bb1 protein toxin expressed in transgenic Bacillus thuringiensis maize. In crosses between, and within, the resistant and susceptible genotypes, no differences occurred in mating frequency, copulation duration, courtship duration, or fertility; however, females mated with resistant males showed reduced longevity. Body size did not vary with genotype. Larger males and females were not more likely to mate than smaller males and females, but larger females laid more eggs. Moderately strong, positive correlation occurred between the body sizes of successfully mated males and females; however, weak correlation also existed for pairs that did not mate. Our study provided only limited evidence for fitness costs associated with the Cry3Bb1-resistant genotype that might reduce the persistence in populations of the resistant genotype but provided additional evidence for size-based, assortative mating, which could favor the persistence of resistant genotypes affecting body size.

Human Neonatal Rotavirus Vaccine (RV3-BB) to Target Rotavirus from Birth.

Science.gov (United States)

Bines, Julie E; At Thobari, Jarir; Satria, Cahya Dewi; Handley, Amanda; Watts, Emma; Cowley, Daniel; Nirwati, Hera; Ackland, James; Standish, Jane; Justice, Frances; Byars, Gabrielle; Lee, Katherine J; Barnes, Graeme L; Bachtiar, Novilia S; Viska Icanervilia, Ajeng; Boniface, Karen; Bogdanovic-Sakran, Nada; Pavlic, Daniel; Bishop, Ruth F; Kirkwood, Carl D; Buttery, Jim P; Soenarto, Yati

2018-02-22

A strategy of administering a neonatal rotavirus vaccine at birth to target early prevention of rotavirus gastroenteritis may address some of the barriers to global implementation of a rotavirus vaccine. We conducted a randomized, double-blind, placebo-controlled trial in Indonesia to evaluate the efficacy of an oral human neonatal rotavirus vaccine (RV3-BB) in preventing rotavirus gastroenteritis. Healthy newborns received three doses of RV3-BB, administered according to a neonatal schedule (0 to 5 days, 8 weeks, and 14 weeks of age) or an infant schedule (8 weeks, 14 weeks, and 18 weeks of age), or placebo. The primary analysis was conducted in the per-protocol population, which included only participants who received all four doses of vaccine or placebo within the visit windows, with secondary analyses performed in the intention-to-treat population, which included all participants who underwent randomization. Among the 1513 participants in the per-protocol population, severe rotavirus gastroenteritis occurred up to the age of 18 months in 5.6% of the participants in the placebo group (28 of 504 babies), in 1.4% in the neonatal-schedule vaccine group (7 of 498), and in 2.7% in the infant-schedule vaccine group (14 of 511). This resulted in a vaccine efficacy of 75% (95% confidence interval [CI], 44 to 91) in the neonatal-schedule group (PBill and Melinda Gates Foundation and others; Australian New Zealand Clinical Trials Registry number, ACTRN12612001282875 .).

Time dependence of the UV resonance lines in the cataclysmic variables SU UMa, RX And and 0623+71

International Nuclear Information System (INIS)

Woods, J.A.; Drew, J.E.; Verbunt, Frank

1990-01-01

We present IUE observations of the dwarf novae SU UMa and RX And, and of the nova-like variable 0623 + 71. At the time of observation, SU UMa and RX And were in outburst. All three systems show variability in the wind-formed UV resonance lines of N v λ 1240, Si IV λ 1397 and C IV λ 1549 on timescale of hours. The amplitude of variation is smallest in RX And and largest in 0623 + 71. There is evidence that the variations observed in SU UMa's UV spectrum repeat on the orbital period. Our observations of SU UMa also reveal variability in the continuum flux during the decline from outburst maximum that is much more marked in the UV than at optical wavelengths. (author)

Advances in astronomy and astrophysics

CERN Document Server

Kopal, Zdenek

1963-01-01

Advances in Astronomy and Astrophysics, Volume 2 brings together numerous research works on different aspects of astronomy and astrophysics. This volume is composed of six chapters and begins with a summary of observational record on twilight extensions of the Venus cusps. The next chapter deals with the common and related properties of binary stars, with emphasis on the evaluation of their cataclysmic variables. Cataclysmic variables refer to an object in one of three classes: dwarf nova, nova, or supernova. These topics are followed by discussions on the eclipse phenomena and the eclipses i

Search for W→cs-bar, Z→cc-bar,bb-bar in muon-jet events at the CERN proton-antiproton collider

International Nuclear Information System (INIS)

Ransdell, J.

1988-01-01

A search for quark decays of the W and Z particles produced in proton-antiproton collisions at √s of 630 GeV in the UA1 experiment at the CERN collider is described. The search was made in the channels W→cs-bar, Z→cc-bar,bb-bar where b and c quarks were identified by the presence of a high-p/sub T/ muon in or near a jet. Although these decay channels avoid the copious background of QCD produced light quark and gluon jets, it was not possible to detect a W or Z signal because of the large cross section for strong cc-bar and bb-bar production

Impact of genetically modified maize expressing Cry 3Bb1 on some non-target arthropods

Czech Academy of Sciences Publication Activity Database

Hussein, Hany; Svobodová, Zdeňka; Habuštová, Oxana; Půža, Vladimír; Sehnal, František

2012-01-01

Roč. 8, č. 10 (2012), s. 5124-5131 ISSN 1819-544X R&D Projects: GA MZe QH91093 Grant - others:projekt MOBITAG(CZ) REGPOT-2008-1, GA 229518 Institutional support: RVO:60077344 Keywords : MON 88017 * Cry3Bb1 * non-target organisms Subject RIV: GF - Plant Pathology, Vermin, Weed, Plant Protection http://www.aensiweb.com/jasr/jasr/2012/5124-5131.pdf

Decays of Higgs bosons to bb-bar, ττ-bar, and cc-bar as signatures of supersymmetry and CP phases

International Nuclear Information System (INIS)

Ibrahim, Tarek; Nath, Pran

2003-01-01

The branching ratio of the lightest Higgs boson decay into bb(bar sign), ττ-bar and cc-bar is sensitive to supersymmetric effects. We include in this work the effects of CP phases on the Higgs boson decays. Specifically we compute the deviation of the CP phase dependent branching ratio from the standard model result. The analysis includes the full one loop corrections of fermion masses including CP phases involving the gluino, the chargino and the neutralino exchanges. The analysis shows that the supersymmetric effects with CP phases can change the branching ratios by as much as 100% for the lightest Higgs boson decay into bb(bar sign) and ττ-bar with similar results holding for the heavier Higgs boson decays. A detailed analysis is also given for the effects of CP phases on the Higgs boson decays into cc-bar. The deviations of R b/τ and R b/c from the standard model result are investigated as a possible signature of supersymmetry and CP effects. Thus a measurement of the decays of the Higgs boson into bb-bar, ττ-bar and cc-bar may provide important clues regarding the existence of supersymmetry and CP phases

Cataclysms and Catastrophes: A Case Study of Improving K-12 Science Education Through a University Partnership

Science.gov (United States)

Fennell, T.; Ellins, K. K.; Morris, M.; Christeson, G.

2003-12-01

The K-12 science teacher is always seeking ways of improving and updating their curriculum by integrating the latest research into their most effective classroom activities. However, the daily demands of delivering instruction to large numbers of students coupled with the rapid advances in some fields of science can often overwhelm this effort. The NSF-sponsored Cataclysms and Catastrophes curriculum, developed by scientists from the The University of Texas at Austin Institute for Geophysics (UTIG) and Bureau of Economic Geology (BEG), middle and high school teachers, and UT graduate students (NSF GK-12 fellows) working together through the GK-12 program, is a textbook example of how universities can facilitate this quest, benefiting education at both K-12 and university levels. In 1992, "The Great K-T Extinction Debate" was developed as an activity in the Planet Earth class at the Liberal Arts and Science Academy of Austin as an interdisciplinary approach to science. Taking advantage of the media attention generated by the impact scenario for the K-T extinction, the activity consists of students participating in a simulated senate hearing on the potential causes of the K-T extinction and their implications for society today. This activity not only exposes students to the wide range of science involved in understanding mass extinctions, but also to the social, political and economic implications when this science is brought into the public arena and the corresponding use of data in decision making and disaster preparedness. While "The Great K-T Extinction Debate" was always a popular and effective activity with students, it was in desperate need of updating to keep pace with the evolving scientific debate over the cause of the K-T extinction and the growing body of impact evidence discovered over the past decade. By adding two inquiry-based learning activities that use real geophysical data collected by scientists studying the buried Chicxulub feature as a

Combined Transcriptome and Proteome Analysis of Bifidobacterium animalis subsp. lactis BB-12 Grown on Xylo-Oligosaccharides and a Model of Their Utilization

DEFF Research Database (Denmark)

Gilad, Ofir; Jacobsen, Susanne; Stuer-Lauridsen, B.

2010-01-01

-documented and widely used probiotic strain B. animalis subsp. lactis BB-12, a combined proteomic and transcriptomic approach was applied, involving DNA microarrays, real-time quantitative PCR (qPCR), and two-dimensional difference gel electrophoresis (2D-DIGE) analyses of samples obtained from cultures grown on either...... of these (beta-D-xylosidase, sugar-binding protein, and xylose isomerase) showed higher abundance on XOS. Based on the obtained results, a model for the catabolism of XOS in BB-12 is suggested, according to which the strain utilizes an ABC (ATP-binding cassette) transport system (probably for oligosaccharides...

Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpura.

Science.gov (United States)

Cao, Wenjing; Pham, Huy P; Williams, Lance A; McDaniel, Jenny; Siniard, Rance C; Lorenz, Robin G; Marques, Marisa B; Zheng, X Long

2016-11-01

Acquired thrombotic thrombocytopenic purpura is primarily caused by the deficiency of plasma ADAMTS13 activity resulting from autoantibodies against ADAMTS13. However, ADAMTS13 deficiency alone is often not sufficient to cause acute thrombotic thrombocytopenic purpura. Infections or systemic inflammation may precede acute bursts of the disease, but the underlying mechanisms are not fully understood. Herein, 52 patients with acquired autoimmune thrombotic thrombocytopenic purpura and 30 blood donor controls were recruited for the study. The plasma levels of human neutrophil peptides 1-3 and complement activation fragments (i.e. Bb, iC3b, C4d, and sC5b-9) were determined by enzyme-linked immunosorbent assays. Univariate analyses were performed to determine the correlation between each biomarker and clinical outcomes. We found that the plasma levels of human neutrophil peptides 1-3 and Bb in patients with acute thrombotic thrombocytopenic purpura were significantly higher than those in the control (Ppurpura patients and the control. We conclude that innate immunity, i.e. neutrophil and complement activation via the alternative pathway, may play a role in the pathogenesis of acute autoimmune thrombotic thrombocytopenic purpura, and a therapy targeted at these pathways may be considered in a subset of these patients. Copyright© Ferrata Storti Foundation.

Pretreatment with platelet derived growth factor-BB modulates the ability of costochondral resting zone chondrocytes incorporated into PLA/PGA scaffolds to form new cartilage in vivo.

Science.gov (United States)

Lohmann, C H; Schwartz, Z; Niederauer, G G; Carnes, D L; Dean, D D; Boyan, B D

2000-01-01

Optimal repair of chondral defects is likely to require both a suitable population of chondrogenic cells and a biodegradable matrix to provide a space-filling structural support during the early stages of cartilage formation. This study examined the ability of chondrocytes to support cartilage formation when incorporated into biodegradable scaffolds constructed from copolymers (PLG) of polylactic acid (PLA) and polyglycolic acid (PGA) and implanted in the calf muscle of nude mice. Scaffolds were fabricated to be more hydrophilic (PLG-H) or were reinforced with 10% PGA fibers (PLG-FR), increasing the stiffness of the implant by 20-fold. Confluent primary cultures of rat costochondral resting zone chondrocytes (RC) were loaded into PLG-H foams and implanted intramuscularly. To determine if growth factor pretreatment could modulate the ability of the cells to form new cartilage, RC cells were pretreated with recombinant human platelet derived growth factor-BB IPDGF-BB) for 4 or 24 h prior to implantation. To assess whether scaffold material properties could affect the ability of chondrogenic cells to form cartilage, RC cells were also loaded into PLG-FR scaffolds. To determine if the scaffolds or treatment with PDGF-BB affected the rate of chondrogenesis, tissue at the implant site was harvested at four and eight weeks post-operatively, fixed, decalcified and embedded in paraffin. Sections were obtained along the transverse plane of the lower leg, stained with haematoxylin and eosin, and then assessed by morphometric analysis for area of cartilage, area of residual implant, and area of fibrous connective tissue formation (fibrosis). Whether or not the cartilage contained hypertrophic cells was also assessed. The amount of residual implant did not change with time in any of the implanted tissues. The area occupied by PLG-FR implants was greater than that occupied by PLG-H implants at both time points. All implants were surrounded by fibrous connective tissue, whether

Proliferation and mitogenic response to PDGF-BB of fibroblasts isolated from chronic venous leg ulcers is ulcer-age dependent

DEFF Research Database (Denmark)

Agren, M S; Steenfos, H H; Dabelsteen, S

1999-01-01

Several pathophysiologic mechanisms have been proposed to explain slow-healing leg ulcers, but little is known about the growth behavior of cells in these wounds. Platelet-derived growth factor-BB applied topically to chronic wounds has shown beneficial effects, although the effects have been less...... pronounced than would have been expected based on studies on acute wounds. The objective of this study was to compare fibroblasts in culture obtained from chronic wounds (non-healing chronic venous leg ulcers), acute wounds and normal dermis regarding growth, mitogenic response to platelet-derived growth...... chronic wounds have approached or even reached the end of their lifespan (phase III). This might provide one explanation for the non-healing state and therapy resistance to topical platelet-derived growth factor-BB of some venous leg ulcers....

rhPDGF-BB promotes early healing in a rat rotator cuff repair model.

Science.gov (United States)

Kovacevic, David; Gulotta, Lawrence V; Ying, Liang; Ehteshami, John R; Deng, Xiang-Hua; Rodeo, Scott A

2015-05-01

Tendon-bone healing after rotator cuff repair occurs by fibrovascular scar tissue formation, which is weaker than a normal tendon-bone insertion site. Growth factors play a role in tissue formation and have the potential to augment soft tissue healing in the perioperative period. Our study aim was to determine if rhPDGF-BB delivery on a collagen scaffold can improve tendon-to-bone healing after supraspinatus tendon repair compared with no growth factor in rats as measured by (1) gross observations; (2) histologic analysis; and (3) biomechanical testing. Ninety-five male Sprague-Dawley rats underwent acute repair of the supraspinatus tendon. Rats were randomized into one of five groups: control (ie, repair only), scaffold only, and three different platelet-derived growth factor (PDGF) doses on the collagen scaffold. Animals were euthanized 5 days after surgery to assess cellular proliferation and angiogenesis. The remaining animals were analyzed at 4 weeks to assess repair site integrity by gross visualization, fibrocartilage formation with safranin-O staining, and collagen fiber organization with picrosirius red staining, and to determine the biomechanical properties (ie, load-to-failure testing) of the supraspinatus tendon-bone construct. The repaired supraspinatus tendon was in continuity with the bone in all animals. At 5 days, rhPDGF-BB delivery on a scaffold demonstrated a dose-dependent response in cellular proliferation and angiogenesis compared with the control and scaffold groups. At 28 days, with the numbers available, rhPDGF-BB had no effect on increasing fibrocartilage formation or improving collagen fiber maturity at the tendon-bone insertion site compared with controls. The control group had higher tensile loads to failure and stiffness (35.5 ± 8.8 N and 20.3 ± 4.5 N/mm) than all the groups receiving the scaffold, including the PDGF groups (scaffold: 27 ± 6.4 N, p = 0.021 and 13 ± 5.7 N/mm, p = 0.01; 30 µg/mL PDGF: 26.5 ± 7.5 N, p = 0.014 and 13

Intermediate polars as low-field magnetic cataclysmic variables

International Nuclear Information System (INIS)

Wickramasinghe, D.T.; Kinwah Wu; Ferrario, Lilia

1991-01-01

We present the first detailed calculations of the polarization properties of extended accretion shocks on the surface of a magnetic white dwarf where allowance is made both for field spread and for the change in shock height as a function of specific accretion rate. These results are used to show conclusively that the null detection of circular polarization in most IPs imply fields of less than 5 MG. We suggest that the X-ray properties of MCVs depends critically on the fractional area of the white-dwarf surface over which accretion occurs, and on the type of accretion (smooth or clumpy). We argue that in the known IPs, accretion occurs via a disc. The accretion flow is smooth and a strong shock forms making them a powerful source of hard X-rays. We propose that there is a new class of MCV distinct from the IPs, where the white dwarf is asynchronous and accretes without a disc in which the accretion is clumpy and the radiation is mainly in the EUV region. (author)

Search for Higgs boson production via weak boson fusion and decaying to bb¯in association with a high-energy photon using the ATLAS detector

CERN Document Server

Liang, Zhijun; The ATLAS collaboration

2017-01-01

A search for the bb¯ decay of the Standard Model Higgs boson produced through vector boson fusion in association with a high transverse energy (ET) photon has been conducted with the ATLAS detector. The high-ET photon provides a distinct signature for both triggering and reducing the large QCD jet background present in the inclusive bb¯jj signature. The talk will focus on new trigger strategy implemented in 2016 data taking to target the specific final state as well as the implementation of the multivariate strategy for the signal extraction. This analysis has been combined with a complementary analysis in the more inclusive bb¯jj final state, which results in a significant improvement in the sensitivity. Results with pp collision data collected in 2015 and 2016 at a centre-of-mass energy of 13 TeV are presented.

In vivo binding of the Cry11Bb toxin of Bacillus thuringiensis subsp. medellin to the midgut of mosquito larvae (Diptera: Culicidae

Directory of Open Access Journals (Sweden)

Ruiz Lina María

2004-01-01

Full Text Available Bacillus thuringiensis subsp. medellin produces numerous proteins among which 94 kDa known as Cry11Bb, has mosquitocidal activity. The mode of action of the Cry11 proteins has been described as similar to those of the Cry1 toxins, nevertheless, the mechanism of action is still not clear. In this study we investigated the in vivo binding of the Cry11Bb toxin to the midgut of the insect species Anopheles albimanus, Aedes aegypti, and Culex quinquefasciatus by immunohistochemical analysis. Spodoptera frugiperda was included as negative control. The Cry11Bb protein was detected on the apical microvilli of the midgut epithelial cells, mostly on the posterior midgut and gastric caeca of the three mosquito species. Additionally, the toxin was detected in the Malpighian tubules of An. albimanus, Ae. aegypti, Cx. quinquefasciatus, and in the basal membrane of the epithelial cells of Ae. aegypti midgut. No toxin accumulation was observed in the peritrophic membrane of any of the mosquito species studied. These results confirm that the primary site of action of the Cry11 toxins is the apical membrane of the midgut epithelial cells of mosquito larvae.

(Tele)Connectivity in climate variability at different spatial/temporal scales in relation to solar and geomagnetic activity

Czech Academy of Sciences Publication Activity Database

Paluš, Milan; Hartman, David; Vejmelka, Martin; Novotná, Dagmar

2011-01-01

Roč. 13, - (2011), s. 9579 ISSN 1607-7962. [European Geosciences Union General Assembly 2011. 03.04.2011-08.04.2011, Vienna] R&D Projects: GA AV ČR IAA300420805 Institutional research plan: CEZ:AV0Z10300504; CEZ:AV0Z30420517 Keywords : climate variability * phase coherence * synchronization * North Atlantic Oscillation * solar activity Subject RIV: BB - Applied Statistics, Operational Research

Assessment of fitness costs in Cry3Bb1 resistant and susceptible western corn rootworm (Coleoptera:Chrysomelidae) laboratory colonies

Science.gov (United States)

Maize production in the United States is dominated by plants genetically modified with transgenes from Bacillus thuringiensis (Bt). Varieties of Bt maize expressing Cry3Bb endotoxins that specifically target corn rootworms (genus Diabrotica) have proven highly efficacious. Howeve...

Search for rare processes with a Z+bb signature at the LHC, with the matrix element method

CERN Document Server

Beluffi, Camille; Lemaitre, Vincent

This thesis presents a detailed study of the final state with the Z boson decaying into two leptons, produced in the CMS detector at the LHC. In order to tag this topology, sophisticated b jet tagging algorithms have been used, and the calibration of one of them, the Jet Probability (JP) tagger is exposed. A study of the tagger degradation at high energy has been done and led to a small gain of performance. This investigation is followed by the search for the associated production of the standard model (SM) Higgs boson with a Z boson and decaying into two b quarks (ZH channel), using the Matrix Element Method (MEM) and two b-taggers: JP and Combined Secondary Vertex (CSV). The MEM is an advanced tool that produces an event-by-event discriminating variable, called weight. To apply it, several sets of transfer function have been produced. The final results give an observed limit on the ZH production cross section with the H → bb branching ratio of 5.46xσSM when using the CSV tagger and 4.89xσSM when using t...

Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis

NARCIS (Netherlands)

Meenan, J.; Grool, T. A.; Hommes, D. W.; Dijkhuizen, S.; ten Kate, F. J.; Wood, M.; Whittaker, M.; Tytgat, G. N.; van Deventer, S. J.

1996-01-01

To assess the anti-inflammatory action of lexipafant (BB-882), a platelet activating factor antagonist, in an animal model of acute colitis. An animal intervention study. Following the rectal instillation of formalin 0.75% into male New Zealand White (NZW) rabbits, 0.85 ml of aggregated

OPTICAL STUDIES OF 13 HARD X-RAY SELECTED CATACLYSMIC BINARIES FROM THE SWIFT-BAT SURVEY

International Nuclear Information System (INIS)

Halpern, Jules P.; Thorstensen, John R.

2015-01-01

From a set of 13 cataclysmic binaries that were discovered in the Swift Burst Alert Telescope (BAT) survey, we conducted time-resolved optical spectroscopy and/or time-series photometry of 11, with the goal of measuring their orbital periods and searching for spin periods. Seven of the objects in this study are new optical identifications. Orbital periods are found for seven targets, ranging from 81 minutes to 20.4 hr. PBC J0706.7+0327 is an AM Herculis star (polar) based on its emission-line variations and large amplitude photometric modulation on the same period. Swift J2341.0+7645 may be a polar, although the evidence here is less secure. Coherent pulsations are detected from two objects, Swift J0503.7−2819 (975 s) and Swift J0614.0+1709 (1412 s and 1530 s, spin and beat periods, respectively), indicating that they are probable intermediate polars (DQ Herculis stars). For two other stars, longer spin periods are tentatively suggested. We also present the discovery of a 2.00 hr X-ray modulation from RX J2015.6+3711, possibly a contributor to Swift J2015.9+3715, and likely a polar

Linking optical and infrared observations with gravitational wave sources through transient variability

International Nuclear Information System (INIS)

Stubbs, C W

2008-01-01

Optical and infrared observations have thus far detected more celestial cataclysms than have been seen in gravity waves (GW). This argues that we should search for gravity wave signatures that correspond to transient variables seen at optical wavelengths, at precisely known positions. There is an unknown time delay between the optical and gravitational transient, but knowing the source location precisely specifies the corresponding time delays across the gravitational antenna network as a function of the GW-to-optical arrival time difference. Optical searches should detect virtually all supernovae that are plausible gravitational radiation sources. The transient optical signature expected from merging compact objects is not as well understood, but there are good reasons to expect detectable transient optical/IR emission from most of these sources as well. The next generation of deep wide-field surveys (for example PanSTARRS and LSST) will be sensitive to subtle optical variability, but we need to fill the 'blind spots' that exist in the galactic plane, and for optically bright transient sources. In particular, a galactic plane variability survey at λ∼ 2 μm seems worthwhile. Science would benefit from closer coordination between the various optical survey projects and the gravity wave community

Hyaluronic acid/Chitosan nanoparticles as delivery vehicles for VEGF and PDGF-BB.

Science.gov (United States)

Parajó, Yolanda; D'Angelo, Ivana; Welle, Alexander; Garcia-Fuentes, Marcos; Alonso, María José

2010-11-01

The development of a vascular network in tissue-engineered constructs is a fundamental bottleneck of bioregenerative medicine, particularly when the size of the implant exceeds a certain limit given by diffusion lengths and/or if the host tissue shows a very active metabolism. One of the approaches to achieve the vascularization of tissue constructs is generating a sustained release of proangiogenic factors from the ischemic site. This work describes the formation and characterization of hyaluronic acid-chitosan (HA/CS) nanoparticles for the delivery of two pro-angiogenic growth factors: vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF-BB). These nanoparticles were prepared by an ionic gelification technique, and different formulations were developed by encapsulating the growth factors in association with two stabilizing agents: bovine serum albumin or heparin sodium salt. These carriers were characterized with regard to their physicochemical properties, their stability in biological media, and their cytotoxicity in the C3a hepatoma cell line. The results show that nanoparticles around 200 nm can be prepared by this method. HA/CS nanoparticles were stable when incubated in EMEM cell culture medium or in water at 37°C for 24 h. Cell culture tests confirmed that HA/CS nanoparticles are not cytotoxic within the concentration range used for growth factor delivery. Moreover, HA/CS nanoparticles were able to entrap efficiently both growth factors, reaching association values of 94% and 54% for VEGF and PDGF, respectively. In vitro release studies confirm that PDGF-BB is released from HA/CS nanoparticles in a sustained manner over approximately 1 week. On the other hand, VEGF is completely released within the first 24 h.

Magnetic Properties of New Triangular Lattice Magnets A${_4}$B'B${_2}$O$_{12}$

OpenAIRE

Rawl, Ryan; Lee, Minseong; Choi, Eun Sang; Li, Guang; Chen, Kuan-Wen; Baumbach, Ryan; Cruz, Clarina R. dela; Ma, Jie; Zhou, Haidong

2017-01-01

The geometrically frustrated two dimensional triangular lattice magnets A${_4}$B'B${_2}$O$_{12}$ (A = Ba, Sr, La; B' = Co, Ni, Mn; B = W, Re) have been studied by x-ray diffraction, AC and DC susceptibilities, powder neutron diffraction, and specific heat measurements. The results reveal that (i) the samples containing Co$^{2+}$ (effective spin-1/2) and Ni$^{2+}$ (spin-1) ions with small spin numbers exhibit ferromagnetic (FM) ordering while the sample containing Mn$^{2+}$ (spin-5/2) ions wit...

Role of 4-1BB receptor in the control played by CD8(+ T cells on IFN-gamma production by Mycobacterium tuberculosis antigen-specific CD4(+ T Cells.

Directory of Open Access Journals (Sweden)

Carla Palma

Full Text Available BACKGROUND: Antigen-specific IFN-gamma producing CD4(+ T cells are the main mediators of protection against Mycobacterium tuberculosis infection both under natural conditions and following vaccination. However these cells are responsible for lung damage and poor vaccine efficacy when not tightly controlled. Discovering new tools to control nonprotective antigen-specific IFN-gamma production without affecting protective IFN-gamma is a challenge in tuberculosis research. METHODS AND FINDINGS: Immunization with DNA encoding Ag85B, a candidate vaccine antigen of Mycobacterium tuberculosis, elicited in mice a low but protective CD4(+ T cell-mediated IFN-gamma response, while in mice primed with DNA and boosted with Ag85B protein a massive increase in IFN-gamma response was associated with loss of protection. Both protective and non-protective Ag85B-immunization generated antigen-specific CD8(+ T cells which suppressed IFN-gamma-secreting CD4(+ T cells. However, ex vivo ligation of 4-1BB, a member of TNF-receptor super-family, reduced the massive, non-protective IFN-gamma responses by CD4(+ T cells in protein-boosted mice without affecting the low protective IFN-gamma-secretion in mice immunized with DNA. This selective inhibition was due to the induction of 4-1BB exclusively on CD8(+ T cells of DNA-primed and protein-boosted mice following Ag85B protein stimulation. The 4-1BB-mediated IFN-gamma inhibition did not require soluble IL-10, TGF-beta, XCL-1 and MIP-1beta. In vivo Ag85B stimulation induced 4-1BB expression on CD8(+ T cells and in vivo 4-1BB ligation reduced the activation, IFN-gamma production and expansion of Ag85B-specific CD4(+ T cells of DNA-primed and protein-boosted mice. CONCLUSION/SIGNIFICANCE: Antigen-specific suppressor CD8(+ T cells are elicited through immunization with the mycobacterial antigen Ag85B. Ligation of 4-1BB receptor further enhanced their suppressive activity on IFN-gamma-secreting CD4(+ T cells. The selective

Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study.

Science.gov (United States)

Toscano, Marco; De Grandi, Roberta; Stronati, Laura; De Vecchi, Elena; Drago, Lorenzo

2017-04-21

To evaluate the ability of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 to colonize the intestinal environment of healthy subjects and modify the gut microbiota composition. Twenty healthy Italian volunteers, eight males and twelve females, participated in the study. Ten subjects took a sachet containing 4 × 10 9 colony-forming units (CFU) of Bifidobacterium longum BB536 and 10 9 CFU of Lactobacillus rhamnosus HN001, 30 min before breakfast (pre-prandial administration), while ten subjects took a sachet of probiotic product 30 min after breakfast (post-prandial administration). The ability of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 to colonize human gut microbiota was assessed by means of quantitative real-time PCR, while changes in gut microbiota composition were detected by using Ion Torrent Personal Genome Machine. Immediately after 1-mo of probiotic administration, B. longum BB536 and L. rhamnosus HN001 load was increased in the majority of subjects in both pre-prandial and post-prandial groups. This increase was found also 1 mo after the end of probiotic oral intake in both groups, if compared to samples collected before probiotic consumption. At phyla level a significant decrease in Firmicutes abundance was detected immediately after 1-mo of B. longum BB536 and L. rhamnosus HN001 oral intake. This reduction persisted up to 1 mo after the end of probiotic oral intake together with a significant decrease of Proteobacteria abundance if compared to samples collected before probiotic administration. Whereas, at species level, a higher abundance of Blautia producta , Blautia wexlerae and Haemophilus ducrey was observed, together with a reduction of Holdemania filiformis , Escherichia vulneris , Gemmiger formicilis and Streptococcus sinensis abundance. In addition, during follow-up period we observed a further reduction in Escherichia vulneris and Gemmiger formicilis , together with a decrease in Roseburia faecis and

A visible and infrared study of the eclipsing dwarf nova OY Carinae

International Nuclear Information System (INIS)

Berriman, G.

1984-01-01

This paper presents four visible light curves of the highly inclined, short-period cataclysmic binary star OY Carinae in quiescence. These light curves show that the red dwarf eclipses both its white dwarf companion and the accretion disc and hotspot, which originate from material transferred from the red dwarf to the white dwarf. The consequences of the findings are discussed in the light of current ideas about the evolution of cataclysmic variable stars. (author)

The spectrum and variability of radio emission from AE Aquarii

Science.gov (United States)

Abada-Simon, Meil; Lecacheux, Alain; Bastian, Tim S.; Bookbinder, Jay A.; Dulk, George A.

1993-01-01

The first detections of the magnetic cataclysmic variable AE Aquarii at millimeter wavelengths are reported. AE Aqr was detected at wavelengths of 3.4 and 1.25 mm. These data are used to show that the time-averaged spectrum is generally well fitted by a power law S(nu) varies as nu exp alpha, where alpha is approximately equal to 0.35-0.60, and that the power law extends to millimeter wavelengths, i.e., the spectral turnover is at a frequency higher than 240 GHz. It is suggested that the spectrum is consistent with that expected from a superposition of flarelike events where the frequency distribution of the initial flux density is a power law f (S0) varies as S0 exp -epsilon, with index epsilon approximately equal to 1.8. Within the context of this model, the high turnover frequency of the radio spectrum implies magnetic field strengths in excess of 250 G in the source.

Search for the Higgs boson in the tt-bar H(H→bb-bar) channel and the identification of jets containing 2 B hadrons with the ATLAS experiment

International Nuclear Information System (INIS)

Ticse Torres, R.E.

2016-01-01

In July 2012, CERN announced the discovery of the Higgs boson, the last missing piece of the Standard Model (SM). The Higgs boson has been observed coupling directly to W and Z bosons and tau leptons, and indirectly to top quarks. Observing the Higgs boson production in association with a pair of top quarks (tt-bar H) would allow a direct measurement of the top quark Yukawa coupling and provides an important test of the Higgs mechanism within the SM. This thesis presents a search for the Higgs boson in the tt-bar H(H→ bb-bar) channel using proton-proton collisions at √s=13 TeV, collected with the ATLAS detector in 2015 and 2016. The Higgs boson decays to two b quarks and top quark pair decays with one lepton, the tt-bar H → (lνb)(jjb)(bb-bar) single lepton channel, are considered. This document details in particular the contributions made by the author in this search: the full reconstruction of the tt-bar H(H → bb-bar) single lepton system and the final discrimination between signal and the main background, tt-bar+jets. A new method was developed to solve the large combinatorial background by fully reconstructing the tt-bar H(H → bb-bar) final state using a multivariate technique to uniquely associate each reconstructed jets to the initial quarks. A multivariate technique was also used to discriminate between the signal and the main tt-bar+jets background further increasing the sensitivity of the search compared to the Run 1 analysis. Finally, the first result at √s=13 TeV shown. The signal strength (the ratio between the measured and predicted cross sections) is found to be 1.6 ± 1.1. No significant excess of events above the background expectation is found and an observed (expected) limit of 3.6 (2.2) is set at 95% confidence level. The tt-bar bb-bar is one of the main backgrounds for the tt-bar H(bb-bar) search. Recent studies with Monte Carlo events generators show that there is a large fraction of tt-bar bb-bar events with jets containing two b

Vertical ridge augmentation using an equine bone and collagen block infused with recombinant human platelet-derived growth factor-BB: a randomized single-masked histologic study in non-human primates.

Science.gov (United States)

Nevins, Myron; Al Hezaimi, Khalid; Schupbach, Peter; Karimbux, Nadeem; Kim, David M

2012-07-01

This study tests the effectiveness of hydroxyapatite and collagen bone blocks of equine origin (eHAC), infused with recombinant human platelet-derived growth factor-BB (rhPDGF-BB), to augment localized posterior mandibular defects in non-human primates (Papio hamadryas). Bilateral critical-sized defects simulating severe atrophy were created at the time of the posterior teeth extraction. Test and control blocks (without growth factor) were randomly grafted into the respective sites in each non-human primate. All sites exhibited vertical ridge augmentation, with physiologic hard- and soft-tissue integration of the blocks when clinical and histologic examinations were done at 4 months after the vertical ridge augmentation procedure. There was a clear, although non-significant, tendency to increased regeneration in the test sites. As in the first two preclinical studies in this series using canines, experimental eHAC blocks infused with rhPDGF-BB proved to be a predictable and technically viable method to predictably regenerate bone and soft tissue in critical-sized defects. This investigation supplies additional evidence that eHAC blocks infused with rhPDGF-BB growth factor is a predictable and technically feasible option for vertical augmentation of severely resorbed ridges.

Short-term dietary adjustment with a hydrolyzed casein-based diet postpones diabetes development in the diabetes-prone BB rat

NARCIS (Netherlands)

Visser, J; Brugman, S; Klatter, F; Vis, L; Groen, H; Strubbe, J; Rozing, J

From earlier studies it appears that weaning associated changes in the animal's physiology and that of the pancreas in particular, render diabetes-prone Bio-Breeding (DP-BB) rats susceptible to the induction and development of insulin-dependent diabetes mellitus (IDDM). In this study we tested

Spatial and temporal variability of carbonaceous aerosols: Assessing the impact of biomass burning in the urban environment.

Science.gov (United States)

Titos, G; Del Águila, A; Cazorla, A; Lyamani, H; Casquero-Vera, J A; Colombi, C; Cuccia, E; Gianelle, V; Močnik, G; Alastuey, A; Olmo, F J; Alados-Arboledas, L

2017-02-01

Biomass burning (BB) is a significant source of atmospheric particles in many parts of the world. Whereas many studies have demonstrated the importance of BB emissions in central and northern Europe, especially in rural areas, its impact in urban air quality of southern European countries has been sparsely investigated. In this study, highly time resolved multi-wavelength absorption coefficients together with levoglucosan (BB tracer) mass concentrations were combined to apportion carbonaceous aerosol sources. The Aethalometer model takes advantage of the different spectral behavior of BB and fossil fuel (FF) combustion aerosols. The model was found to be more sensitive to the assumed value of the aerosol Ångström exponent (AAE) for FF (AAE ff ) than to the AAE for BB (AAE bb ). As result of various sensitivity tests the model was optimized with AAE ff =1.1 and AAE bb =2. The Aethalometer model and levoglucosan tracer estimates were in good agreement. The Aethalometer model was further applied to data from three sites in Granada urban area to evaluate the spatial variation of CM ff and CM bb (carbonaceous matter from FF or BB origin, respectively) concentrations within the city. The results showed that CM bb was lower in the city centre while it has an unexpected profound impact on the CM levels measured in the suburbs (about 40%). Analysis of BB tracers with respect to wind speed suggested that BB was dominated by sources outside the city, to the west in a rural area. Distinguishing whether it corresponds to agricultural waste burning or with biomass burning for domestic heating was not possible. This study also shows that although traffic restrictions measures contribute to reduce carbonaceous concentrations, the extent of the reduction is very local. Other sources such as BB, which can contribute to CM as much as traffic emissions, should be targeted to reduce air pollution. Copyright © 2016 Elsevier B.V. All rights reserved.

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

DEFF Research Database (Denmark)

Yang, Yunlong; Andersson, Patrik; Hosaka, Kayoko

2016-01-01

Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33......-ST2-dependent pathway in xenograft mouse models of cancer. IL-33 is the highest upregulated gene through activation of SOX7 transcription factor in PDGF-BB-stimulated pericytes. Gain- and loss-of-function experiments validate that IL-33 promotes metastasis through recruitment of TAMs. Pharmacological...... inhibition of the IL-33-ST2 signalling by a soluble ST2 significantly inhibits TAMs and metastasis. Genetic deletion of host IL-33 in mice also blocks PDGF-BB-induced TAM recruitment and metastasis. These findings shed light on the role of tumour stroma in promoting metastasis and have therapeutic...

Doppler Tomography

Science.gov (United States)

Marsh, T. R.

I review the method of Doppler tomography which translates binary-star line profiles taken at a series of orbital phases into a distribution of emission over the binary. I begin with a discussion of the basic principles behind Doppler tomography, including a comparison of the relative merits of maximum entropy regularisation versus filtered back-projection for implementing the inversion. Following this I discuss the issue of noise in Doppler images and possible methods for coping with it. Then I move on to look at the results of Doppler Tomography applied to cataclysmic variable stars. Outstanding successes to date are the discovery of two-arm spiral shocks in cataclysmic variable accretion discs and the probing of the stream/magnetospheric interaction in magnetic cataclysmic variable stars. Doppler tomography has also told us much about the stream/disc interaction in non-magnetic systems and the irradiation of the secondary star in all systems. The latter indirectly reveals such effects as shadowing by the accretion disc or stream. I discuss all of these and finish with some musings on possible future directions for the method. At the end I include a tabulation of Doppler maps published in refereed journals.

4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4+CD25+FoxP3+ T Regulatory Cell Suppression.

Directory of Open Access Journals (Sweden)

Hampartsoum B Barsoumian

Full Text Available Costimulation with the recombinant SA-4-1BBL agonist of 4-1BB receptor on conventional CD4+ T cells (Tconvs overcomes the suppression mediated by naturally occurring CD4+CD25+FoxP3+ T regulatory cells (Tregs. The mechanistic basis of this observation has remained largely unknown. Herein we show that Tconvs, but not Tregs, are the direct target of SA-4-1BBL-mediated evasion of Treg suppression. IL-2 produced by Tconvs in response to 4-1BB signaling is both necessary and sufficient for overcoming Treg suppression. Supernatant from Tconvs stimulated with SA-4-1BBL contains high levels of IL-2 and overcomes Treg suppression in ex vivo Tconv:Treg cocultures. Removal of IL-2 from such supernatant restores Treg suppression and repletion of Tconv:Treg cocultures with exogenous recombinant IL-2 overcomes suppression. This study establishes 4-1BB signaling as a key circuit that regulates physical and functional equilibrium between Tregs and Tconvs with important implications for immunotherapy for indications where a fine balance between Tregs and Teffs plays a decisive role.

Short-Term Dietary Adjustment With a Hydrolyzed Casein–Based Diet Postpones Diabetes Development in the Diabetes-Prone BB Rat

NARCIS (Netherlands)

Visser, Jeroen; Brugman, Sylvia; Klatter, Flip; Vis, Lotte; Groen, Herman; Strubbe, Jan; Rozing, Jan

2003-01-01

From earlier studies it appears that weaning associated changes in the animal’s physiology and that of the pancreas in particular, render diabetes-prone Bio-Breeding (DP-BB) rats susceptible to the induction and development of insulin-dependent diabetes mellitus (IDDM). In this study we tested

A decadal (2002-2014 analysis for dynamics of heterotrophic bacteria in an Antarctic coastal ecosystem: variability and physical and biogeochemical forcings

Directory of Open Access Journals (Sweden)

Hyewon Kim

2016-11-01

Full Text Available We investigated the dynamics of heterotrophic bacteria in the coastal western Antarctic Peninsula (WAP, using decadal (2002-2014 time series of two bacterial variables, bacterial production (BP via 3H-leucine incorporation rates and bacterial biomass (BB via bacterial abundance, collected at Palmer Antarctica Long Term Ecological Research (LTER Station B (64.8°S, 64.1°W over a full austral growing season (October-March. Strong seasonal and interannual variability in the degree of bacterial coupling with phytoplankton processes were observed with varying lags. On average, BP was only 4% of primary production (PP, consistent with low BP:PP ratios observed in polar waters. BP was more strongly correlated with chlorophyll (Chl, than with PP, implying that bacteria feed on DOC produced from a variety of trophic levels (e.g. zooplankton sloppy feeding and excretion as well as directly on phytoplankton-derived DOC. The degree of bottom-up control on bacterial abundance was moderate and relatively consistent across entire growing seasons, suggesting that bacteria in the coastal WAP are under consistent DOC limitation. Temperature also influenced BP rates, though its effect was weaker than DOC. We established generalized linear models (GLMs for monthly composites of BP and BB via stepwise regression to explore a set of physical and biogeochemical predictors. Physically, high BP and large BB were shaped by a stratified water-column, similar to forcing mechanisms favoring phytoplankton blooms, but high sea surface temperature (SST also significantly promoted bacterial processes. High BP and large BB were influenced by high PP and bulk DOC concentrations. Based on these findings, we suggest an increasingly important role of marine heterotrophic bacteria in the coastal WAP food-web as climate change introduces a more favorable environmental setting for promoting BP, with increased DOC from retreating glaciers, a more stabilized upper water-column from ice

Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions.

Directory of Open Access Journals (Sweden)

Bérengère Vire

Full Text Available Histone deacetylase inhibitors (HDACi have demonstrated promising therapeutic potential in clinical trials for hematological malignancies. HDACi, such as SAHA/Vorinostat, Trichostatin A, and MS-275 were found to induce apoptosis of leukemic blasts through activation of the death receptor pathway and transcriptional induction of the Tumor Necrosis Factor (TNF-related pro-apoptotic family members, TRAIL and FasL. The impact of HDACi on TNF-related costimulatory molecules such as 4-1BB ligand (4-1BBL/TNFSF9 is however not known. Following exposure to SAHA/Vorinostat, Trichostatin A, and MS-275, transcript levels were determined by real time PCR in Jurkat, Raji and U937 cells. Treatment with HDACi up-regulated TNFSF9 gene expression in the three leukemia cell lines, yet to different extend and with distinct kinetics, which did not require de novo protein synthesis and was not associated with DNAse I hypersensitive chromatin remodeling. Transcriptional activity of TNFSF9 promoter-luciferase constructs was induced up to 12 fold by HDACi, and implication of Sp1/Sp3 transcription factors binding to functional GC-box elements was evidenced by reporter gene assays, site-directed mutagenesis, and electrophoretic mobility shift assays. Functionality of modulated target genes was assessed in allogeneic mixed leukocyte reaction experiments. MS-275- and to a lesser extent Trichostatin A- and SAHA-treated Raji cells significantly up regulated T lymphocytes proliferation which was reduced by about 50% by a 4-1BB blocking recombinant protein, while MS-275- but neither Trichostatin A- nor SAHA-treated cells up-regulated IFNgamma secretion by T lymphocytes. Our results identify 4-1BBL/4-1BB as a downstream target of HDACi, especially of MS-275 anti-leukemia action in vitro. Thus, HDACi such as MS-275 displaying dual TNF-dependent proapoptotic and costimulatory activities might be favored for inclusion in HDACi-based anti-cancer therapeutic strategies.

Evidence for the H to bb decay in VH production with the ATLAS detector

CERN Multimedia

CERN. Geneva

2017-01-01

Most Higgs bosons are expected to decay to a pair of b-quarks, with the Standard Model predicting a branching fraction of about 58%. Probing this decay is important to furthering our understanding of the Higgs sector, but its observation at hadron colliders is complicated by overwhelming Standard Model backgrounds. In this seminar, a search for the Higgs to bb decay, looking at the associated production of the Higgs boson with a W or Z boson, is presented using 36 fb-1 of 13 TeV LHC Run 2 data.

Microencapsulation and Fermentation of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12

Directory of Open Access Journals (Sweden)

Maryam Yari

2015-09-01

Full Text Available Because of poor survival of probiotic bacteria, microencapsulation evolved from the immobilized cell culture technology used in the biotechnological industry. Two probiotic strains, Bifidobacterium (BB-12 and Lactobacillus acidophilus (LA-5 were immobilized in calcium alginate by extrusion method. Encapsulation parameters and efficacy of this method were evaluated. Growth factors of these two bacteria were also measured by culturing in 10-L fermenter. Growth curves were obtained with respect to optical density and dry biomass weight. Encapsulation yield was over than 60% in each experiment. Scanning electron microscopy (SEM of Entrapment of cells in alginate matrix and cross-sections of dried bead were obtained and illustrated. Bifidobacterium have been shown better biotechnological properties.

The Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models.

Science.gov (United States)

Brito, Marlon V; de Oliveira, Cleide; Salu, Bruno R; Andrade, Sonia A; Malloy, Paula M D; Sato, Ana C; Vicente, Cristina P; Sampaio, Misako U; Maffei, Francisco H A; Oliva, Maria Luiza V

2014-05-01

The Bauhinia bauhinioides Kallikrein Inhibitor (BbKI) is a Kunitz-type serine peptidase inhibitor of plant origin that has been shown to impair the viability of some tumor cells and to feature a potent inhibitory activity against human and rat plasma kallikrein (Kiapp 2.4 nmol/L and 5.2 nmol/L, respectively). This inhibitory activity is possibly responsible for an effect on hemostasis by prolonging activated partial thromboplastin time (aPTT). Because the association between cancer and thrombosis is well established, we evaluated the possible antithrombotic activity of this protein in venous and arterial thrombosis models. Vein thrombosis was studied in the vena cava ligature model in Wistar rats, and arterial thrombosis in the photochemical induced endothelium lesion model in the carotid artery of C57 black 6 mice. BbKI at a concentration of 2.0 mg/kg reduced the venous thrombus weight by 65% in treated rats in comparison to rats in the control group. The inhibitor prolonged the time for total artery occlusion in the carotid artery model mice indicating that this potent plasma kallikrein inhibitor prevented thrombosis. Copyright © 2014 Elsevier Ltd. All rights reserved.

Strategic Marketing Proposal Plan For A Cosmetics Company : BB Cream of Maybelline New York Vietnam

OpenAIRE

Nguyen, Quynh

2015-01-01

Background. Maybelline New York is one of the world’s leading cosmetics brands, with availability in more than 100 countries around the world. Since it first entered the Vietnamese market in 2007, the brand has grown rapidly and dominated the mass makeup market in the categories of Eye and Lip. However, BB Cream is a highly potential market that the company has not exploited. Aims. The aim of this study is about gaining valuable consumer insights in order to suggest strategic proposals t...

Facile insertion of a cyclic alkyl(amino) carbene carbon into the B-B bond of diboron(4) reagents.

Science.gov (United States)

Eichhorn, Antonius F; Kuehn, Laura; Marder, Todd B; Radius, Udo

2017-10-24

We report herein the room temperature insertion of the carbene carbon atom of the cyclic (alkyl)(amino) carbene cAAC Me into the B-B single bonds of the diboron(4) compounds B 2 pin 2 , B 2 cat 2 , B 2 neop 2 , and B 2 eg 2 (pin = pinacolato, cat = catecholato, neop = neopentylglycolato, eg = ethyleneglycolato).

The Impact of Storage Conditions on the Stability of Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis Bb12 in Human Milk.

Science.gov (United States)

Mantziari, Anastasia; Aakko, Juhani; Kumar, Himanshu; Tölkkö, Satu; du Toit, Elloise; Salminen, Seppo; Isolauri, Erika; Rautava, Samuli

2017-11-01

Human milk is the optimal source of complete nutrition for neonates and it also guides the development of infant gut microbiota. Importantly, human milk can be supplemented with probiotics to complement the health benefits of breastfeeding. Storage of human milk for limited periods of time is often unavoidable, but little is known about the effect of different storage conditions (temperature) on the viability of the added probiotics. Therefore, in this study, we evaluated how different storage conditions affect the viability of two specific widely used probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis subsp. lactis (Bb12), in human milk by culturing and quantitative polymerase chain reaction. Our results indicate that LGG and Bb12 remained stable throughout the storage period. Thus, we conclude that human milk offers an appropriate matrix for probiotic supplementation.

Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats: relationships to islet volume and glucose transport rate.

OpenAIRE

Tominaga, M; Komiya, I; Johnson, J H; Inman, L; Alam, T; Moltz, J; Crider, B; Stefan, Y; Baetens, D; McCorkle, K

1986-01-01

The insulin and glucagon responses to 10 mM glucose and 10 mM arginine were studied in pancreata isolated from nondiabetic diabetes-prone and diabetes-resistant BB/W rats at 60, 80, and 140 days of age and in diabetic BB/W rats on the 1st and 14th days of their diabetes. In the former group the insulin response to glucose declined progressively with age (r = -0.575; P less than 0.01) and at 140 days was significantly below age-matched diabetes-resistant controls (P less than 0.05). The insuli...

Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi.

Science.gov (United States)

Cordes, Frank S; Kraiczy, Peter; Roversi, Pietro; Simon, Markus M; Brade, Volker; Jahraus, Oliver; Wallis, Russell; Goodstadt, Leo; Ponting, Chris P; Skerka, Christine; Zipfel, Peter F; Wallich, Reinhard; Lea, Susan M

2006-05-01

Borrelia burgdorferi, a spirochaete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease, the most frequent vector-borne disease in Eurasia and North America. Sporadically Lyme disease develops into a chronic, multisystemic disorder. Serum-resistant B. burgdorferi strains bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochaete surface. This binding is dependent on the expression of proteins termed complement-regulator acquiring surface proteins (CRASPs). The atomic structure of BbCRASP-1, the key FHL-1/FH-binding protein of B. burgdorferi, has recently been determined. Our analysis indicates that its protein topology apparently evolved to provide a high affinity interaction site for FH/FHL-1 and leads to an atomic-level hypothesis for the functioning of BbCRASP-1. This work demonstrates that pathogens interact with complement regulators in ways that are distinct from the mechanisms used by the host and are thus obvious targets for drug design.

Assessment of stress tolerance acquisition in the heat-tolerant derivative strains of Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus rhamnosus GG.

Science.gov (United States)

Aakko, J; Sánchez, B; Gueimonde, M; Salminen, S

2014-07-01

The purpose of this study was to investigate the heat-shock response at molecular level in Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12 and their heat-tolerant derivatives and to characterize the changes that make the derivatives more robust in terms of heat stress. The study strains were exposed for 2 h to a heat-shock treatment, Bif. animalis subsp. lactis BB-12 and its derivative at 50°C and the Lact. rhamnosus GG and its derivative at 60°C. Protein synthesis before and after heat shock was examined using proteomics and RT-qPCR. The analysis revealed that the regulation of seven proteins in both strain pairs was modified as a response to heat or between the original and the derivative strain. The comparison of wild-type strains and the heat-tolerant derivatives suggests that the acquisition of heat tolerance in the Bif. animalis subsp. lactis BB-12 derivative is due to a slightly increased constitutive level of chaperones, while in Lact. rhamnosus GG derivative, the main reason seems to be a higher ability to induce the production of chaperones. This study revealed possible markers of heat tolerance in B. lactis and Lact. rhamnosus strains. This study increases our knowledge on how Lactobacillus and Bifidobacterium strains may acquire heat tolerance. These findings may be useful for improving the heat tolerance of existing probiotic strains as well as screening new heat-tolerant strains. © 2014 The Society for Applied Microbiology.

Excited state mass spectra of doubly heavy baryons Ω{sub cc}, Ω{sub bb} and Ω{sub bc}

Energy Technology Data Exchange (ETDEWEB)

Shah, Zalak; Rai, Ajay Kumar [Sardar Vallabhbhai National Institute of Technology, Department of Applied Physics, Surat, Gujarat (India); Thakkar, Kaushal [GIDC Degree Engineering college, Department of Applied Sciences and Humanities, Abrama, Navsari (India)

2016-10-15

We discuss the mass spectrum of Ω baryon with two heavy quarks and one light quark (ccs, bbs, and bcs). The main goal of the paper is to calculate the ground state masses and after that, the positive and negative parity excited states masses are also obtained within a hypercentral constituent quark model, using Coulomb plus linear potential framework. We also added a first order correction to the potential. The mass spectra up to 5S for radial excited states and 1P-5P, 1D-4D, and 1F-2F states for orbital excited states are computed for Ω{sub cc}, Ω{sub bb} and Ω{sub bc} baryons. Our obtained results are compared with other theoretical predictions, which could be a useful complementary tool for the interpretation of experimentally unknown heavy baryon spectra. The Regge trajectory is constructed in both the (n{sub r}, M{sup 2}) and the (J, M{sup 2}) planes for Ω{sub cc}, Ω{sub bb} and Ω{sub bc} baryons and their slopes and intercepts are also determined. Magnetic moments of doubly heavy Ω{sup '}s are also calculated. (orig.) 8.

76 FR 55720 - BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the...

Science.gov (United States)

2011-09-08

... approval under section 312 of the Act and Section 107.730 (a)(4), Provide Financing to a Small Business to... SMALL BUSINESS ADMINISTRATION [License No. 04/04-0311] BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of...

40 CFR 174.518 - Bacillus thuringiensis Cry3Bb1 protein in corn; exemption from the requirement of a tolerance.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Bacillus thuringiensis Cry3Bb1 protein in corn; exemption from the requirement of a tolerance. 174.518 Section 174.518 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PROCEDURES AND REQUIREMENTS FOR PLANT-INCORPORATED PROTECTANTS Tolerances and...

IGF-1 and PDGF-bb Suppress IL-1β-Induced Cartilage Degradation through Down-Regulation of NF-κB Signaling: Involvement of Src/PI-3K/AKT Pathway

Science.gov (United States)

Mobasheri, Ali; Buhrmann, Constanze; Aldinger, Constance; Rad, Jafar Soleimani; Shakibaei, Mehdi

2011-01-01

Objective Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA. Herein, we investigated the potential synergistic effects of insulin-like growth factor (IGF-1) and platelet-derived growth factor (PDGF-bb) on different mechanisms participating in IL-1β-induced activation of nuclear transcription factor-κB (NF-κB) and apoptosis in chondrocytes. Methods Primary chondrocytes were treated with IL-1β to induce dedifferentiation and co-treated with either IGF-1 or/and PDGF-bb and evaluated by immunoblotting and electron microscopy. Results Pretreatment of chondrocytes with IGF-1 or/and PDGF-bb suppressed IL-1β-induced NF-κB activation via inhibition of IκB-α kinase. Inhibition of IκB-α kinase by GFs led to the suppression of IκB-α phosphorylation and degradation, p65 nuclear translocation and NF-κB-regulated gene products involved in inflammation and cartilage degradation (COX-2, MMPs) and apoptosis (caspase-3). GFs or BMS-345541 (specific inhibitor of the IKK) reversed the IL-1β-induced down-regulation of collagen type II, cartilage specific proteoglycans, β1-integrin, Shc, activated MAPKinase, Sox-9 and up-regulation of active caspase-3. Furthermore, the inhibitory effects of IGF-1 or/and PDGF-bb on IL-1β-induced NF-κB activation were sensitive to inhibitors of Src (PP1), PI-3K (wortmannin) and Akt (SH-5), suggesting that the pathway consisting of non-receptor tyrosine kinase (Src), phosphatidylinositol 3-kinase and protein kinase B must be involved in IL-1β signaling. Conclusion The results presented suggest that IGF-1 and PDGF-bb are potent inhibitors of IL-1β-mediated activation of NF-κB and apoptosis in chondrocytes, may be mediated in part through suppression of Src/PI-3K/AKT pathway, which may contribute to their anti-inflammatory effects. PMID

Studies of b-jets reconstruction and identification in LHCb experiment in order to determine its sensibility to a standard model Higgs decaying in bb-bar pairs

International Nuclear Information System (INIS)

Coco, Victor

2008-01-01

LHCb sensitivity to a standard model Higgs in the H + (W, Z) → bb-bar + (ll-bar, ν l l) channel has been studied. Different effects affecting jet reconstruction have been studied at generator and full simulation of the detector level. After correction di-b-jet, mass resolution is σ m /m moyen = 22%. b-jet identification procedure has been set up, selecting ∼ 80% of b-jets while rejecting ∼ 99.5% of other jets. After reducing the bb-bar + l physical background, a statistical significance of 1 is obtained for 4 years of data taking at a luminosity of 5.10 32 cm -2 s -1 . (author)

Relationship of classical novae to other eruptive variables

International Nuclear Information System (INIS)

Vogt, N.

1989-01-01

Classical novae are characterized by their well known large-amplitude outbursts, accompanied by the ejection of a shell. The same stars, however, apparently pass through much longer quiescent phases whose duration exceeds that of the outburst phase by a factor ∼ 10 5 and that of historical nova records by a factor 10 2 -10 3 . Therefore a large number of variable stars should exist which actually are classical nova systems but whose last outbursts occurred in prehistoric times. We assume that some of these stars are hidden among the so-called 'nova-lies' in the literature. However some eruptive variables and symbiotic stars, i.e. stars which certainly are not nova remnants, are mentioned. Variables related to classical novae can be divided into three main classes: (i) Potential novae which are possibly classical novae in their quiescent state. Potential novae must share the basic configuration and parameters (orbital period, masses) with classical novae; they must be semi-detached cataclysmic binaries with a white dwarf as primary and a Roche-lobe-filling red dwarf on, or near, the mainsequence as secondary. (ii) Stars which share some outburst characteristics with classical novae without having the same binary configuration. For example recurrent novae with giant secondaries, very slow novae (and symbiotic binary stars). (iii) Stars which are evolutionarily related to classical novae, i.e. which possibly are progenitors or successors of novae in their secular evolution, such as binary nuclei of planetary nebulae and close, but detached, white dwarf-red dwarf pairs (e.g. V 471 Tau), both resulting from common-envelope evolution. These three main groups of nova-related stars are discussed. (author)

The R band light curves of eclipses of U Gem in outburst

Czech Academy of Sciences Publication Activity Database

Šimon, Vojtěch

č. 5453 (2003), s. 1-4 ISSN 0374-0676 Institutional research plan: CEZ:AV0Z1003909 Keywords : cataclysmic variables * general binaries stars Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model.

Directory of Open Access Journals (Sweden)

Zineb Belcaid

Full Text Available Glioblastoma (GBM is the most common malignant brain tumor in adults and is associated with a poor prognosis. Cytotoxic T lymphocyte antigen -4 (CTLA-4 blocking antibodies have demonstrated an ability to generate robust antitumor immune responses against a variety of solid tumors. 4-1BB (CD137 is expressed by activated T lymphocytes and served as a co-stimulatory signal, which promotes cytotoxic function. Here, we evaluate a combination immunotherapy regimen involving 4-1BB activation, CTLA-4 blockade, and focal radiation therapy in an immune-competent intracranial GBM model.GL261-luciferace cells were stereotactically implanted in the striatum of C57BL/6 mice. Mice were treated with a triple therapy regimen consisted of 4-1BB agonist antibodies, CTLA-4 blocking antibodies, and focal radiation therapy using a small animal radiation research platform and mice were followed for survival. Numbers of brain-infiltrating lymphocytes were analyzed by FACS analysis. CD4 or CD8 depleting antibodies were administered to determine the relative contribution of T helper and cytotoxic T cells in this regimen. To evaluate the ability of this immunotherapy to generate an antigen-specific memory response, long-term survivors were re-challenged with GL261 glioma en B16 melanoma flank tumors.Mice treated with triple therapy had increased survival compared to mice treated with focal radiation therapy and immunotherapy with 4-1BB activation and CTLA-4 blockade. Animals treated with triple therapy exhibited at least 50% long-term tumor free survival. Treatment with triple therapy resulted in a higher density of CD4+ and CD8+ tumor infiltrating lymphocytes. Mechanistically, depletion of CD4+ T cells abrogated the antitumor efficacy of triple therapy, while depletion of CD8+ T cells had no effect on the treatment response.Combination therapy with 4-1BB activation and CTLA-4 blockade in the setting of focal radiation therapy improves survival in an orthotopic mouse

Forsythoside A Inhibits BVDV Replication via TRAF2-Dependent CD28-4-1BB Signaling in Bovine PBMCs.

Directory of Open Access Journals (Sweden)

Quan-Jiang Song

Full Text Available Bovine viral diarrhea virus (BVDV, the causative agent of bovine viral diarrhea/mucosal disease (BVD/MD, is an important pathogen of cattle and other wild animals throughout the world. BVDV infection typically leads to an impaired immune response in cattle. In the present study, we investigated the effect of Forsythoside A (FTA on BVDV infection of bovine peripheral blood mononuclear cells (PBMCs. We found that Forsythoside A could not only promote proliferation of PBMCs and T cells activation but also inhibit the replication of BVDV as well as apoptosis induced by BVDV. FTA treatment could counteract the BVDV-induced overproduction of IFN-γ to maintain the immune homeostasis in bovine PBMCs. At same time, FTA can enhance the secretion of IL-2. What's more, BVDV promotes the expression of CD28, 4-1BB and TRAF-2, which can be modulated by FTA. Our data suggest that FTA protects PBMCs from BVDV infection possibly via TRAF2-dependent CD28-4-1BB signaling, which may activate PBMCs in response to BVDV infection. Therefore, this aids in the development of an effective adjuvant for vaccines against BVDV and other specific FTA-based therapies for preventing BVDV infection.

Rotavirus specific maternal antibodies and immune response to RV3-BB neonatal rotavirus vaccine in New Zealand

OpenAIRE

Chen, Mee-Yew; Kirkwood, Carl D.; Bines, Julie; Cowley, Daniel; Pavlic, Daniel; Lee, Katherine J.; Orsini, Francesca; Watts, Emma; Barnes, Graeme; Danchin, Margaret

2017-01-01

Background: Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccines observed in children in developing countries. This study aimed to investigate the effect of rotavirus specific maternal antibodies on the serum IgA response or stool excretion of vaccine virus after any dose of an oral rotavirus vaccine, RV3-BB, in parallel to a Phase IIa clinical trial conducted at Dunedin Hospital, New Zealand. At the time o...

Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII

DEFF Research Database (Denmark)

Gbahou, F; Holst, B; Schwartz, T W

2010-01-01

Epitopes determining the agonist property of two structurally distinct selective ligands for the human bombesin receptor subtype 3 (BB3), [D-Tyr6,(R)-Apa11,Phe13, Nle14]-bombesin(6-14) (Pep-1) and Ac-Phe-Trp-Ala-His(TauBzl)-Nip-Gly-Arg-NH2 (Pep-2), were mapped through systematic mutagenesis...

Forsythoside A Inhibits BVDV Replication via TRAF2-Dependent CD28–4-1BB Signaling in Bovine PBMCs

Science.gov (United States)

Song, Quan-Jiang; Weng, Xiao-Gang; Cai, Dong-Jie; Zhang, Wang; Wang, Jiu-Feng

2016-01-01

Bovine viral diarrhea virus (BVDV), the causative agent of bovine viral diarrhea/mucosal disease (BVD/MD), is an important pathogen of cattle and other wild animals throughout the world. BVDV infection typically leads to an impaired immune response in cattle. In the present study, we investigated the effect of Forsythoside A (FTA) on BVDV infection of bovine peripheral blood mononuclear cells (PBMCs). We found that Forsythoside A could not only promote proliferation of PBMCs and T cells activation but also inhibit the replication of BVDV as well as apoptosis induced by BVDV. FTA treatment could counteract the BVDV-induced overproduction of IFN-γ to maintain the immune homeostasis in bovine PBMCs. At same time, FTA can enhance the secretion of IL-2. What’s more, BVDV promotes the expression of CD28, 4-1BB and TRAF-2, which can be modulated by FTA. Our data suggest that FTA protects PBMCs from BVDV infection possibly via TRAF2-dependent CD28–4-1BB signaling, which may activate PBMCs in response to BVDV infection. Therefore, this aids in the development of an effective adjuvant for vaccines against BVDV and other specific FTA-based therapies for preventing BVDV infection. PMID:27617959

Využití měr variability pro nominální proměnné ve vícerozměrné statistické analýze

Czech Academy of Sciences Publication Activity Database

Řezanková, Hana; Šulc, Z.; Húsek, Dušan

2016-01-01

Roč. 12, č. 1 (2016), s. 34-43 ISSN 1336-7420 Grant - others:IGA VŠE(CZ) F4/41/2016 Institutional support: RVO:67985807 Keywords : míry variability * nominální proměnné * vícerozměrná analýza * míry závislosti * míry podobnosti * shluková analýza * rozhodovací stromy * hodnocení klasifikace * variability measures * nominal variables * multivariate analysis * dependence measures * similarity measures * cluster analysis * decision trees * classification evaluation Subject RIV: BB - Applied Statistics, Operational Research http://www.ssds.sk/casopis/archiv/2016/fss0116.pdf

Interleukin-1 beta (IL-1) does not reduce the diabetes incidence in diabetes-prone BB rats

DEFF Research Database (Denmark)

Reimers, J I; Mørch, L; Markholst, H

1994-01-01

The cytokine interleukin 1 beta (IL-1) has been implicated as a pathogenetic factor in the initial events leading to insulin-dependent diabetes mellitus. Previous studies investigating the impact of IL-1 on diabetes incidence in spontaneously diabetic rodent models have been conflicting. IL-1...... concentrations at diagnosis, but did not change the diabetes incidence in DP BB rats. The results are not in conflict with the hypothesis that IL-1 is a pathogenetic factor in IDDM, caused by high local concentrations of rat IL-1 in the islets during early insulitis. The results also show the necessity of pair...

Influence of the addition of Lactobacillus acidophilus La-05, Bifidobacterium animalis subsp. lactis Bb-12 and inulin on the technological, physicochemical, microbiological and sensory features of creamy goat cheese.

Science.gov (United States)

Barbosa, Ilsa C; Oliveira, Maria E G; Madruga, Marta S; Gullón, Beatriz; Pacheco, Maria T B; Gomes, Ana M P; Batista, Ana S M; Pintado, Maria M E; Souza, Evandro L; Queiroga, Rita C R E

2016-10-12

The effects of the addition of Lactobacillus acidophilus LA-05, Bifidobacterium animalis subsp. lactis BB-12 and inulin on the quality characteristics of creamy goat cheese during refrigerated storage were evaluated. The manufactured cheeses included the addition of starter culture (Lactococcus lactis subsp. lactis and Lactococcus lactis subsp. cremoris - R-704) (CC); starter culture, L. acidophilus LA-05 and inulin (CLA); starter culture, B. lactis BB-12 and inulin (CBB); or starter culture, L. acidophilus LA-05, B. lactis BB-12 and inulin (CLB). In the synbiotic cheeses (CLA, CBB and CLB), the counts of L. acidophilus LA-05 and B. lactis BB-12 were greater than 6log CFU g -1 , the amount of inulin was greater than 6 g per 100 g, and the firmness was reduced. The cheeses evaluated had high brightness values (L*), with a predominance of yellow (b*). CC had higher contents of proteins, lipids and minerals compared to the other cheeses. There was a decrease in the amount of short-chain fatty acids (SCFAs) and an increase of medium-chain (MCFAs) and long-chain fatty acids (LCFAs) in the synbiotic cheeses compared to CC. The amount of conjugated linoleic acid increased in CLA, CBB and CLB. The highest depth of proteolysis and the greatest changes in the release of free amino acids were found in CLB. The addition of inulin and probiotics, alone or in co-culture, did not affect the cheese acceptance. Inulin and probiotics can be used together for the production of creamy goat cheese without negatively affecting the general quality characteristics of the product, and to add value because of its synbiotic potential.

Evidence for idiotypic- and antiidiotypic B-B cellular interaction with the use of cloned antiidiotypic B cell line.

Science.gov (United States)

Bitoh, S; Fujimoto, S; Yamamoto, H

1990-03-15

Immunization of BALB/c mice with MOPC104E myeloma protein induces antiidiotypic B lymphocytes that have Id-specific enhancing activity on antibody production. The B-B cell interaction was restricted to both Igh and class II MHC. However, anti-Thy-1 and C-treated splenic B cells were maintained for more than 1 y in a mixture of Con A-stimulated splenocyte culture supernatant and synthetic medium. In applying the long term culture method, we have established a cloned B cell line named B19-1d, B19-1d cells are specific to MOPC104E or J558 cross-reactive Id and they express surface mu, lambda but no Ly-1. B19-1d do not spontaneously secrete Ig but produce them upon stimulation with bacterial LPS. The effect of B19-1d cell line on idiotypic antibody production was tested. Addition of only 10 to 100 B19-1d cells into dextran-immune B cell culture greatly enhanced the Id+ antidextran antibody responses. On the contrary, the antidextran antibody production was suppressed by the higher doses of B19-1d cells. The effective cooperation between dextran-immune B cells and B19-1d cloned B cells was restricted to class II MHC. The role of idiotypic- and antiidiotypic B-B cell interaction in immune regulation and repertoire generation was suggested.

Local Application of Gelatin Hydrogel Sheets Impregnated With Platelet-Derived Growth Factor BB Promotes Tendon-to-Bone Healing After Rotator Cuff Repair in Rats.

Science.gov (United States)

Tokunaga, Takuya; Ide, Junji; Arimura, Hitoshi; Nakamura, Takayuki; Uehara, Yusuke; Sakamoto, Hidetoshi; Mizuta, Hiroshi

2015-08-01

To determine whether the local application of platelet-derived growth factor BB (PDGF-BB) in hydrogel sheets would promote healing and improve histologic characteristics and biomechanical strength after rotator cuff (RC) repair in rats. To assess the effect of PDGF-BB on tendon-to-bone healing we divided 36 adult male Sprague-Dawley rats treated with bilateral surgery to repair the supraspinatus tendon at its insertion site into 3 groups: group 1 = suture-only group; group 2 = suture and gelatin hydrogel sheets impregnated with phosphate-buffered saline (PBS); and group 3 = suture and gelatin hydrogel sheets impregnated with PDGF-BB (0.5 μg). Semiquantitative histologic evaluation was carried out 2, 6, and 12 weeks later; cell proliferation was assessed 2 and 6 weeks postoperatively by immunostaining for proliferating cell nuclear antigen (PCNA), and biomechanical testing, including ultimate load to failure, stiffness, and ultimate stress to failure, was performed 12 weeks after the operation. At 2 weeks, the average percentage of PCNA-positive cells at the insertion site was significantly higher in group 3 (40.5% ± 2.4%) than in group 1 (32.1% ± 6.9%; P = .03) and group 2 (31.9% ± 3.7%; P = .02). At 2 and 6 weeks, the histologic scores were similar among the 3 groups. At 12 weeks, the histologic score was significantly higher in group 3 (10.3 ± 0.8) than in group 1 (8.5 ± 0.5; P = .002) or group 2 (8.8 ± 0.8; P = .009), whereas ultimate load to failure, stiffness, and ultimate load to stress (normal control population, 44.73 ± 9.75 N, 27.59 ± 4.32 N/mm, and 21.33 ± 4.65 N/mm(2), respectively) were significantly higher in group 3 (28.28 ± 6.28 N, 11.05 ± 2.37 N/mm, and 7.99 ± 2.13 N/mm(2), respectively) than in group 1 (10.44 ± 1.98 N, 4.74 ± 1.31 N/mm, and 3.28 ± 1.27 N/mm(2), respectively; all P repair in humans. Copyright © 2015 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

The January 2015 outburst of a red nova in M31

Czech Academy of Sciences Publication Activity Database

Kurtenkov, A.A.; Pessev, P.; Tomov, T.; Barsukova, E.A.; Fabrika, S.; Vida, K.; Hornoch, Kamil; Ovcharov, E.P.; Goranskij, V.P.; Valeev, A.F.; Molnár, L.; Sárneczky, K.; Kostov, A.; Nedialkov, P.; Valenti, S.; Geier, S.; Wiersema, K.; Henze, M.; Shafter, A.W.; Dimitrova, R.V.M.; Popov, V.N.; Stritzinger, M.

2015-01-01

Roč. 578, June (2015), L10/1-L10/5 ISSN 0004-6361 Institutional support: RVO:67985815 Keywords : novae * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.378, year: 2014

Human histologic evaluation of anorganic bovine bone mineral combined with recombinant human platelet-derived growth factor BB in maxillary sinus augmentation: case series study.

Science.gov (United States)

Nevins, Myron; Garber, David; Hanratty, James J; McAllister, Bradley S; Nevins, Marc L; Salama, Maurice; Schupbach, Peter; Wallace, Steven; Bernstein, Simon M; Kim, David M

2009-12-01

The objective of this proof-of-principle study was to examine the potential for improved bone regenerative outcomes in maxillary sinus augmentation procedures when recombinant human platelet-derived growth factor BB (0.3 mg/mL) is combined with particulate anorganic bovine bone mineral. The surgical outcomes in all treated sites were uneventful at 6 to 8 months, with sufficient regenerated bone present to allow successful placement of maxillary posterior implants. Large areas of dense, well-formed lamellar bone were seen throughout the intact core specimens in more than half of the grafted sites. Abundant numbers of osteoblasts were noted in concert with significant osteoid in all sites, indicating ongoing osteogenesis. A number of cores demonstrated efficient replacement of the normally slowly resorbing anorganic bovine bone mineral matrix particles with newly formed bone when the matrix was saturated with recombinant human platelet-derived growth factor BB.

Modeling the optical radiation of the precataclysmic variable SDSS J212531-010745

Science.gov (United States)

Shimansky, V. V.; Borisov, N. V.; Nurtdinova, D. N.; Solovyeva, Yu. N.; Sakhibullin, N. A.; Spiridonova, O. I.

2015-03-01

Optical observations are analyzed to derive a set of basic parameters for the precataclysmic variable star SDSS J212531-010745, whose primary is a PG1159-type star. Spectroscopic and multiband photometric observations of the star were performed in 2008-2011 with the 6-m telescope and the Zeiss-1000 telescope of the Special Astrophysical Observatory. The shape of the binary's orbital light curves is nearly sinusoidal, with the amplitude increasing with wavelength from Δ m = 0.40 m in the B band to Δ m = 0.73 m in the R band. The spectra contain absorption lines of HeII and neutral atoms, along with HI, HeI, CII, MgII, FeII emission lines, whose intensity increases synchronously with the brightness of the system. The optical radiation from SDSS J212531-010745 has a composite nature, corresponding to a model for a pre-cataclysmic variable with strong reflection effects. Cross-correlation techniques are used to measure the radial velocities and derive the component masses. Numerical modeling of the binary's light curves, radial velocities, and spectra is performed, and a complete set of parameters determined. Considerable abundance anomalies (to 1 dex) were detected for the secondary. The primary's characteristics correspond to the evolutionary predictions for DAO dwarfs with masses M ≈ 0.5 M ⊙, and the secondary's characteristics to low-mass, main-sequence stars with the solar metallicity.

Procesos técnicos y culturales durante el Holoceno inicial en el noroeste de la Península Ibérica. Los niveles B y Bb de La Cativera (El Catllar, Tarragona

Directory of Open Access Journals (Sweden)

Morales, Juan Ignacio

2013-06-01

Full Text Available This study presents the technological structure observed in levels B and Bb (Boreal from La Cativera. A dual technological pattern is observed. For one side simplified blade exploitation is observed and for the other, a normalized short flake production is documented too. A new 14C data corroborates the chronological position of both levels despite showing technical schemes which significantly vary from those of synchronous sites. The B and Bb levels match in time with the so called Notched and Denticulate Mesolithic industries, however the observed knapping patterns present a major affinity with the Late Magdalenian or Epipalaeolithic Late Glacial knapping schemes.Este trabajo presenta la estructura tecnológica observada en los niveles B y Bb (Boreal de La Cativera, donde se observa una dualidad entre explotaciones laminares simplificadas y una producción de lascas cortas normalizadas. Una nueva datación inédita refuerza la posición cronológica de estos niveles pese a que las estrategias de talla de los mismos difieren significativamente de las documentadas en yacimientos sincrónicos. Los niveles B y Bb coinciden en el tiempo con los conjuntos del Mesolítico de Muescas y Denticulados, sin embargo el análisis tecnológico de la industria lítica lo pone en relación más directa con los conjuntos del Magdaleniense final y/o Epipaleolítico microlaminar propios del Tardiglaciar.

Potencial do soro de leite líquido como agente encapsulante de Bifidobacterium Bb-12 por spray drying: comparação com goma arábica Potential of liquid whey as the encapsulating agent of Bifidobacterium Bb-12 by spray drying: comparison with arabic gum

Directory of Open Access Journals (Sweden)

Fabiane Picinin de Castro-Cislaghi

2012-09-01

Full Text Available O objetivo do trabalho foi avaliar o potencial do soro de leite líquido como agente encapsulante de Bifidobacterium Bb-12 por spray drying, comparando-o com a goma arábica, a qual é tradicionalmente utilizada na tecnologia de microencapsulação. Foram determinados o rendimento da microencapsulação e a viabilidade das microcápsulas durante o armazenamento. Quando o soro de leite foi utilizado como agente encapsulante, o rendimento da microencapsulação foi maior e a viabilidade das células manteve-se elevada e constante durante doze semanas. O soro de leite apresentou-se como um eficiente agente encapsulante de Bifidobacterium por spray drying.The objective of this study was to evaluate the potential of liquid whey as the encapsulating agent Bifidobacterium Bb-12 by spray drying, compared with arabic gum, which is typically used in microencapsulation technology. The microencapsulation yield and viability during storage were determined. When the whey was used as the encapsulating agent, the microencapsulation yield was higher, and cell viability remained high and steady for twelve weeks. The whey was shown to be an effective encapsulating agent of Bifidobacterium by spray drying.

Anupama, Prof. Gadiyara Chakrapani

Indian Academy of Sciences (India)

Specialization: Time Domain Astronomy, Cataclysmic Variables, Supernovae, Gamma-Ray Burst Sources, Active Galactic Nuclei Address: Senior Professor, Indian Institute of Astrophysics, Sarjapur Road, Koramangala, Bengaluru 560 034, Karnataka Contact: Office: (080) 2254 1344. Residence: (080) 6697 3104

The Nova Rate in NGC 2403

Czech Academy of Sciences Publication Activity Database

Franck, J.R.; Shafter, A.W.; Hornoch, Kamil; Misselt, K.A.

2012-01-01

Roč. 760, č. 1 (2012), 13-1-13-8 ISSN 0004-637X Institutional support: RVO:67985815 Keywords : galaxy NGC 2403 * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 6.733, year: 2012

Chromospheric activity of periodic variable stars (including eclipsing binaries) observed in DR2 LAMOST stellar spectral survey

Science.gov (United States)

Zhang, Liyun; Lu, Hongpeng; Han, Xianming L.; Jiang, Linyan; Li, Zhongmu; Zhang, Yong; Hou, Yonghui; Wang, Yuefei; Cao, Zihuang

2018-05-01

The LAMOST spectral survey provides a rich databases for studying stellar spectroscopic properties and chromospheric activity. We cross-matched a total of 105,287 periodic variable stars from several photometric surveys and databases (CSS, LINEAR, Kepler, a recently updated eclipsing star catalogue, ASAS, NSVS, some part of SuperWASP survey, variable stars from the Tsinghua University-NAOC Transient Survey, and other objects from some new references) with four million stellar spectra published in the LAMOST data release 2 (DR2). We found 15,955 spectra for 11,469 stars (including 5398 eclipsing binaries). We calculated their equivalent widths (EWs) of their Hα, Hβ, Hγ, Hδ and Caii H lines. Using the Hα line EW, we found 447 spectra with emission above continuum for a total of 316 stars (178 eclipsing binaries). We identified 86 active stars (including 44 eclipsing binaries) with repeated LAMOST spectra. A total of 68 stars (including 34 eclipsing binaries) show chromospheric activity variability. We also found LAMOST spectra of 12 cataclysmic variables, five of which show chromospheric activity variability. We also made photometric follow-up studies of three short period targets (DY CVn, HAT-192-0001481, and LAMOST J164933.24+141255.0) using the Xinglong 60-cm telescope and the SARA 90-cm and 1-m telescopes, and obtained new BVRI CCD light curves. We analyzed these light curves and obtained orbital and starspot parameters. We detected the first flare event with a huge brightness increase of more than about 1.5 magnitudes in R filter in LAMOST J164933.24+141255.0.

Optimising charged Higgs boson searches at the Large Hadron Collider across bb¯W± final states

Directory of Open Access Journals (Sweden)

Stefano Moretti

2016-09-01

Full Text Available In the light of the most recent data from Higgs boson searches and analyses, we re-assess the scope of the Large Hadron Collider in accessing heavy charged Higgs boson signals in bb¯W± final states, wherein the contributing channels can be H+→tb¯, hW±, HW± and AW±. We consider a 2-Higgs Doublet Model Type-II and we assume as production mode bg→tH−+c.c., the dominant one over the range MH±≥480 GeV, as dictated by b→sγ constraints. Prospects of detection are found to be significant for various Run 2 energy and luminosity options.

The intermediate polar GK Persei: An unstable relation of the X-ray and the optical intensities in a series of outbursts

Czech Academy of Sciences Publication Activity Database

Šimon, Vojtěch

2015-01-01

Roč. 575, March (2015), A65/1-A65/8 ISSN 0004-6361 Institutional support: RVO:67985815 Keywords : accretion disks * radiation mechanisms * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.378, year: 2014

Quantum authentication based on the randomness of measurement bases in BB84

International Nuclear Information System (INIS)

Dang Minh Dung; Bellot, P.; Alleaume, R.

2005-01-01

Full text: The establishment of a secret key between two legitimate end points of a communication link, let us name them Alice and Bob, using Quantum key distribution (QKD) is unconditionally secure thanks to Quantum Physics laws.However, the various QKD protocols do not intend to provide the authentication of the end points: Alice cannot be sure that she is communicating with Bob and reciprocally. Therefore, these protocols are subjects to various attacks. The most obvious attack is the man-in-the-middle attack in which an eavesdropper, let us name her Eve, stands in the middle of the communication link. Alice communicates with Eve meanwhile she thinks she communicate with Bob. And Bob communicates with Eve meanwhile he thinks he is communicating with Alice. Eve, acting as a relay, can read all the communications between Alice and Bob and retransmit them. To prevent this kind of attack, the solution is to authenticate the two end points of the communication link. One solution is that Alice and Bob share an authentication key prior to the communication. In order to improve the security, Alice and Bob must share a set of authentication one-time keys. One-time key means that the key has to be used only once because each time a key is used, the eavesdropper Eve can gain a few information on the key. Re-using the same key many times would finally reveal the key to Eve. However, Eve can simulate many times the authentication process with Alice. Each time Eve simulates the authentication process, one of the pre-positioned keys is depleted leading to the exhaustion of the set of pre-positioned keys. This type of attack is named Denial of Service attack. In this work, we propose to use the randomness of the measurement bases in BB84 to build an authentication scheme based on the existence of a prepositioned authentication key. This authentication scheme can be used with BB84 but also with any other Quantum Key Distribution protocols. It is protected against the Denial of

Estimates of genetic variability in mutated population of triticum aestivum

International Nuclear Information System (INIS)

Larik, A.S.; Siddiqui, K.A.; Soomoro, A.H.

1980-01-01

M 2 populations of four cultivars of Mexican origin (Mexipak-65, Nayab, Pak-70 and 6134 x C-271) and two locally bred cultivars (H-68 and C-591) of bread wheat, triticum aestivum (2n = 6x = AA BB DD) derived from six irradiation treatments (gamma rays 60sub(Co); 10, 15 and 20 kR and fast neutrons; 300, 600 and 900 RADS) were critically examined for spike length, spikelets per spike, grains per spike and grain yield. Genotypes varied significantly (p>=0.01) for all the characters. Irradiation treatment were instrumental in creating significant variability for all the characters, indicating that varieties did not perform uniformly across different gamma rays as well as fast neutron treatments. In the M 2 generation there was a considerable increase in variance for all the four metrical traits. Comparisons were made between controls and treated populations. Mutagenic treatments shifted the mean values mostly towards the negative direction, but the shift was not unidirectional nor equally effective for all the characters. The differences in mean values and the nature of variability observed in M 2 indicated a possible preference of selection M 3 generation. In general, estimates of genetic variability and heritability (b.s) increased with increasing doses of gamma rays and fast neutrons. Genetic advance also exhibited similar trend. The observed variability can be utilized in the evolution of new varieties. (authors)

Recurrent Novae in M31

Czech Academy of Sciences Publication Activity Database

Shafter, A.W.; Henze, M.; Rector, T. A.; Schweizer, F.; Hornoch, Kamil; Orio, M.; Pietsch, W.; Darnley, M.J.; Williams, S.C.; Bode, M.F.; Bryan, J.

2015-01-01

Roč. 216, č. 2 (2015), 34/1-34/35 ISSN 0067-0049 Institutional support: RVO:67985815 Keywords : individual (M31) galaxies * stellar content * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 11.257, year: 2015

M31N 2008-12a - The Remarkable Recurrent Nova in M31: Panchromatic Observations of the 2015 Eruption

Czech Academy of Sciences Publication Activity Database

Darnley, M.J.; Henze, M.; Bode, M.F.; Haciusu, I.; Hernanz, M.; Hornoch, Kamil; Hounsell, R.; Kato, M.; Ness, J.-U.; Osborne, J.P.

2016-01-01

Roč. 833, č. 2 (2016), 149/1-149/38 ISSN 0004-637X Institutional support: RVO:67985815 Keywords : individual galaxies * novae cataclysmic variables * individual stars Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 5.533, year: 2016

A remarkable recurrent nova in M31: Discovery and optical/UV observations of the predicted 2014 eruption

Czech Academy of Sciences Publication Activity Database

Darnley, M.J.; Henze, M.; Steele, I.A.; Bode, M.F.; Ribeiro, V.A.R.M.; Rodriguez-Gil, P.; Shafter, A.W.; Williams, S.C.; Baer, D.; Hachisu, I.; Hernanz, M.; Hornoch, Kamil; Hounsell, R.A.; Kato, M.; Kiyota, S.; Kučáková, Hana; Maehara, H.; Ness, J.-U.; Piascik, A.S.; Sala, G.; Skillen, I.; Smith, R. J.; Wolf, M.

2015-01-01

Roč. 580, August (2015), A45/1-A45/23 ISSN 0004-6361 Institutional support: RVO:67985815 Keywords : individual (M31) galaxies * novae * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.378, year: 2014

Supersoft X-rays reveal a classical nova in the M 31 globular cluster Bol 126

Czech Academy of Sciences Publication Activity Database

Henze, M.; Pietsch, W.; Haberl, F.; Della Valle, M.; Riffeser, A.; Salla, G.; Hatzidimitriou, D.; Hofmann, F.; Hartmann, D.H.; Koppenhoefer, J.; Seitz, S.; Williams, G.; Hornoch, Kamil; Itagaki, K.; Kabashima, F.; Nishiyama, K.; Xing, G.; Lee, C.H.; Magnier, E.; Chambers, K.

2013-01-01

Roč. 549, January (2013), A120/1-A120/15 ISSN 0004-6361 Institutional support: RVO:67985815 Keywords : galaxies individual M 31 * novae * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.479, year: 2013

Safety and immunogenicity of RV3-BB human neonatal rotavirus vaccine administered at birth or in infancy: a randomised, double-blind, placebo-controlled trial.

Science.gov (United States)

Bines, Julie E; Danchin, Margaret; Jackson, Pamela; Handley, Amanda; Watts, Emma; Lee, Katherine J; West, Amanda; Cowley, Daniel; Chen, Mee-Yew; Barnes, Graeme L; Justice, Frances; Buttery, Jim P; Carlin, John B; Bishop, Ruth F; Taylor, Barry; Kirkwood, Carl D

2015-12-01

Despite the success of rotavirus vaccines, suboptimal vaccine efficacy in regions with a high burden of disease continues to present a challenge to worldwide implementation. A birth dose strategy with a vaccine developed from an asymptomatic neonatal rotavirus strain has the potential to address this challenge and provide protection from severe rotavirus disease from birth. This phase 2a randomised, double-blind, three-arm, placebo-controlled safety and immunogenicity trial was undertaken at a single centre in New Zealand between Jan 13, 2012, and April 17, 2014. Healthy, full-term (≥36 weeks gestation) babies, who weighed at least 2500 g, and were 0-5 days old at the time of randomisation were randomly assigned (1:1:1; computer-generated; telephone central allocation) according to a concealed block randomisation schedule to oral RV3-BB vaccine with the first dose given at 0-5 days after birth (neonatal schedule), to vaccine with the first dose given at about 8 weeks after birth (infant schedule), or to placebo. The primary endpoint was cumulative vaccine take (serum immune response or stool shedding of vaccine virus after any dose) after three doses. The immunogenicity analysis included all randomised participants with available outcome data. This trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611001212943. 95 eligible participants were randomised, of whom 89 were included in the primary analysis. A cumulative vaccine take was detected in 27 (90%) of 30 participants in the neonatal schedule group after three doses of RV3-BB vaccine compared with four (13%) of 32 participants in the placebo group (difference in proportions 0·78, 95% CI 0·55-0·88; pvaccine take after three doses compared with eight (25%) of 32 participants in the placebo group (difference in proportions 0·68, 0·44-0·81; pvaccine was not associated with an increased frequency of fever or gastrointestinal symptoms compared with placebo. RV3-BB vaccine was

The relation between the long-term X-ray and optical activity of the polar AM Her (RX J1816.2+4952)

Czech Academy of Sciences Publication Activity Database

Šimon, Vojtěch

2011-01-01

Roč. 16, č. 6 (2011), s. 405-411 ISSN 1384-1076 Institutional research plan: CEZ:AV0Z10030501 Keywords : radiation mechanisms * cataclysmic variables * X-rays Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.411, year: 2011

Multicolour photometry and spectroscopy of the slow nova V475 Sct (Nova Scuti 2003)

Czech Academy of Sciences Publication Activity Database

Chochol, D.; Katysheva, N.A.; Pribulla, T.; Schmidtobreick, L.; Shugarov, S.Yu.; Škoda, Petr; Šlechta, Miroslav; Vittone, A.A.; Volkov, I. M.

2006-01-01

Roč. 6, č. 1 (2006), s. 137-142 ISSN 1009-9271 Institutional research plan: CEZ:AV0Z10030501 Keywords : cataclysmic variables * circumstellar matter * stars: novae Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 0.746, year: 2006

Influence of experimental parameters inherent to optical fibers on Quantum Key Distribution, the protocol BB84

Directory of Open Access Journals (Sweden)

L. Bouchoucha

2018-03-01

Full Text Available In this work, we represent the principle of quantum cryptography (QC that is based on fundamental laws of quantum physics. QC or Quantum Key Distribution (QKD uses various protocols to exchange a secret key between two communicating parties. This research paper focuses and examines the quantum key distribution by using the protocol BB84 in the case of encoding on the single-photon polarization and shows the influence of optical components parameters on the quantum key distribution. We also introduce Quantum Bit Error Rate (QBER to better interpret our results and show its relationship with the intrusion of the eavesdropper called Eve on the optical channel to exploit these vulnerabilities.

Cooperative effects in differentiation and proliferation between PDGF-BB and matrix derived synthetic peptides in human osteoblasts

Directory of Open Access Journals (Sweden)

Vordemvenne Thomas

2011-11-01

Full Text Available Abstract Background Enhancing osteogenic capabilities of bone matrix for the treatment of fractures and segmental defects using growth factors is an active area of research. Recently, synthetic peptides like AC- 100, TP508 or p-15 corresponding to biologically active sequences of matrix proteins have been proven to stimulate bone formation. The platelet-derived growth factor (PDGF BB has been identified as an important paracrine factor in early bone healing. We hypothesized that the combined use of PDGF-BB with synthetic peptides could result in an increase in proliferation and calcification of osteoblast-like cells. Methods Osteoblast-like cell cultures were treated with PDGF and synthetic peptides, singly and as combinations, and compared to non-treated control cell cultures. The cultures were evaluated at days 2, 5, and 10 in terms of cell proliferation, calcification and gene expression of alkaline phosphate, collagen I and osteocalcin. Results Experimental findings revealed that the addition of PDGF, p-15 and TP508 and combinations of PDGF/AC-100, PDGF/p-15 and PDGF/TP508 resulted in an increase in proliferating osteoblasts, especially in the first 5 days of cultivation. Proliferation did not significantly differ between single factors and factor combinations (p > 0.05. The onset of calcification in osteoblasts occurred earlier and was more distinct compared to the corresponding control or PDGF stimulation alone. Significant difference was found for the combined use of PDGF/p-15 and PDGF/AC-100 (p Conclusions Our findings indicate that PDGF exhibits cooperative effects with synthetic peptides in differentiation and proliferation. These cooperative effects cause a significant early calcification of osteoblast-like cells (p

Impact of Bifidobacterium animalis subsp. lactis BB-12 and, Lactobacillus acidophilus LA-5-containing yoghurt, on fecal bacterial counts of healthy adults.

Science.gov (United States)

Savard, Patricia; Lamarche, Benoît; Paradis, Marie-Eve; Thiboutot, Hélène; Laurin, Émilie; Roy, Denis

2011-09-01

This randomized, placebo-controlled, double blind, parallel dose-response study investigated the impact of 4-week commercial yoghurt consumption supplemented with Bifidobacterium animalis subsp. lactis (BB-12) and Lactobacillus acidophilus (LA-5) on fecal bacterial counts of healthy adults. Fifty-eight volunteers were randomly assigned to three different groups: 1. placebo (no probiotic, no starter and no green tea extract); 2. Yoptimal (10(9)cfu/100g of BB-12 and LA-5 and 40mg of green tea extract) and 3. Yoptimal-10 (10(10)cfu/100g of BB-12, 10(9)cfu/100g of LA-5 and 40mg of green tea extract). These yoghurt products also contained Lactobacillus delbrueckii subsp. bulgaricus (10(7)cfu/100g) and Streptococcus thermophilus (10(10)cfu/100g). The quantitative PCR (qPCR) results showed that there were significant increases (P=0.02) in bifidobacteria counts with the Yoptimal treatment as compared to baseline. The fecal numbers of B. animalis subsp. lactis and LA-5 significantly increased in the two probiotic treatments compared to the placebo treatment. Viable counts of fecal lactobacilli were significantly higher (P=0.05) and those of enterococci were significantly lower (P=0.04) after the intervention when compared to placebo. No significant difference was observed between treatments in volunteers' weight, waist girth, blood pressure, fasting plasma triglyceride and HDL-C concentrations, as well as cholesterol/HDL-cholesterol ratio. However, a significant increase in plasma cholesterol levels was observed in the placebo group (P=0.0018) but the levels remained stable in the two probiotic yoghurt groups. These results show that probiotic strains supplemented in the form of yoghurt remain active during gut transit and are associated with an increase in beneficial bacteria and a reduction in potentially pathogenic bacteria. This trial was registered at clinicaltrials.gov as NCT00730626. Copyright © 2011 Elsevier B.V. All rights reserved.

A Spectroscopic and Photometric Survey of Novae in M31

Czech Academy of Sciences Publication Activity Database

Shafter, A.W.; Darnley, M.J.; Hornoch, Kamil; Filippenko, A.V.; Bode, M.F.; Ciardullo, R.; Misselt, K.A.; Hounsell, R.A.; Chornock, R.; Matheson, T.

2011-01-01

Roč. 734, č. 1 (2011), 12/1-12/28 ISSN 0004-637X Institutional research plan: CEZ:AV0Z10030501 Keywords : individual galaxy (M31) * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 6.024, year: 2011

Journal of Astrophysics and Astronomy | Indian Academy of Sciences

Indian Academy of Sciences (India)

2016-01-27

14 a cataclysmic variable, PG 1336-018 a binary with an sdB pulsator and finally HR 1217 a roAp star. The paper concludes with what the limitations are in our observations and how we can overcome them in the future.

New Fellows and Honorary Fellow

Indian Academy of Sciences (India)

Date of birth: 19 June 1952. Specialization: X-ray Instrumentation for Astronomy, Active Galactic Nuclei and Cataclysmic Variables, Stellar Coronae, Hot Interstellar & Intracluster Media and Supernova Remnants Address: 28A, Bank Colony, Patiala 147 001, Panjab Contact: Mobile: 90048 38965. Email: kulinderpal@gmail.

The spectroscopic evolution of the symbiotic-like recurrent nova V407 Cygni during its 2010 outburst II. The circumstellar environment and the aftermath

Czech Academy of Sciences Publication Activity Database

Shore, S. N.; Wahlgren, G.M.; Augusteijn, T.; Liimets, T.; Koubský, Pavel; Šlechta, Miroslav; Votruba, Viktor

2012-01-01

Roč. 540, April (2012), A55/1-A55/15 ISSN 0004-6361 Institutional support: RVO:67985815 Keywords : gamma-ray burst * cataclysmic variables stars * star V407 Cygni Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 5.084, year: 2012

IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis

DEFF Research Database (Denmark)

Sparre, T; Bjerre-Christensen, Ulla; Mose Larsen, P

2002-01-01

of 82 out of 1 815 protein spots detected by two dimensional gel electrophoresis in IL-1beta exposed diabetes prone Bio Breeding (BB-DP) rat islets of Langerhans in vitro. The aim of this study was to identify the proteins in these 82 spots by mass spectrometry and compare these changes with those seen......Type I (insulin-dependent) diabetes mellitus is characterized by selective destruction of the insulin producing beta cells. Interleukin-1beta (IL-1beta) modulates the beta-cell function, protein synthesis, energy production and causes apoptosis. We have previously shown changes in the expression...

High-velocity winds from a dwarf nova during outburst

Science.gov (United States)

Cordova, F. A.; Mason, K. O.

1982-01-01

An ultraviolet spectrum of the dwarf nova TW Vir during an optical outburst shows shortward-shifted absorption features with edge velocities as high as 4800 km/s, about the escape velocity of a white dwarf. A comparison of this spectrum with the UV spectra of other cataclysmic variables suggests that mass loss is evident only for systems with relatively high luminosities (more than about 10 solar luminosities) and low inclination angles with respect to the observer's line of sight. The mass loss rate for cataclysmic variables is of order 10 to the -11th solar mass per yr; this is from 0.01 to 0.001 of the mass accretion rate onto the compact star in the binary. The mass loss may occur by a mechanism similar to that invoked for early-type stars, i.e., radiation absorbed in the lines accelerates the accreting gas to the high velocities observed.

The TT, TB, EB and BB correlations in anisotropic inflation

Energy Technology Data Exchange (ETDEWEB)

Chen, Xingang [Department of Physics, The University of Texas at Dallas, Richardson, TX 75083 (United States); Emami, Razieh [School of Physics, Institute for Research in Fundamental Sciences (IPM), P. O. Box 19395-5531, Tehran (Iran, Islamic Republic of); Firouzjahi, Hassan [School of Astronomy, Institute for Research in Fundamental Sciences (IPM), P. O. Box 19395-5531, Tehran (Iran, Islamic Republic of); Wang, Yi, E-mail: Xingang.Chen@utdallas.edu, E-mail: emami@ipm.ir, E-mail: firouz@ipm.ir, E-mail: yw366@cam.ac.uk [Centre for Theoretical Cosmology, DAMTP, University of Cambridge, Cambridge CB3 0WA (United Kingdom)

2014-08-01

The ongoing and future experiments will measure the B-mode from different sky coverage and frequency bands, with the potential to reveal non-trivial features in polarization map. In this work we study the TT, TB, EB and BB correlations associated with the B-mode polarization of CMB map in models of charged anisotropic inflation. The model contains a chaotic-type large field complex inflaton which is charged under the U(1) gauge field. We calculate the statistical anisotropies generated in the power spectra of the curvature perturbation, the tensor perturbation and their cross-correlation. It is shown that the asymmetry in tensor power spectrum is a very sensitive probe of the gauge coupling. While the level of statistical anisotropy in temperature power spectrum can be small and satisfy the observational bounds, the interactions from the gauge coupling can induce large directional dependence in tensor modes. This will leave interesting anisotropic fingerprints in various correlations involving the B-mode polarization such as the TB cross-correlation which may be detected in upcoming Planck polarization data. In addition, the TT correlation receives an anisotropic contribution from the tensor sector which naturally decays after l ∼> 100. We expect that the mechanism of using tensor sector to induce asymmetry at low l to be generic which can also be applied to address other low l CMB anomalies.

Dark blood versus bright blood T2* acquisition in cardiovascular magnetic resonance (CMR) for thalassaemia major (TM) patients: Evaluation of feasibility, reproducibility and image quality

Energy Technology Data Exchange (ETDEWEB)

Liguori, Carlo, E-mail: c.liguori@unicampus.it [Department of Diagnostic Imaging, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy); Di Giampietro, Ilenia; Pitocco, Francesca; De Vivo, Aldo Eros [Department of Diagnostic Imaging, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy); Schena, Emiliano [Unit of Measurements and Biomedical Instrumentation, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy); Mortato, Luca [Department of Diagnostic Imaging, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy); Pirro, Federica [Department of Biomaging and Radiological Sciences, Catholic University of Sacred Herart, Largo A. Gemelli 1, 00135 Rome (Italy); Cianciulli, Paolo [Thalassemia Unit, Ospedale Sant Eugenio, Piazzale dell’Umanesimo 10, 00143 Rome (Italy); Zobel, Bruno Beomonte [Department of Diagnostic Imaging, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy)

2014-01-15

Objectives: To compare the effectiveness of dark blood (DB) versus bright blood (BB) sequences. To assess the intra and inter-observer variability and inter-study reproducibility between BB versus DB. To evaluate image quality level in the two sequences. Methods: In a setting of 138 patients we performed CMR using cardiac gated Gradient-multiecho single breath-hold BB and DB sequences in the middle ventricular septum. Each acquisition was repeated during the same exam. Truncation method was used to account for background noise. Image quality (IQ) was assessed using a 5 point grading scale and image analysis was conducted by 2 experienced observers. Results: Compared with the conventional BB acquisition, the coefficient of correlation and significance of the DB technique was superior for intra-observer reproducibility (p < 0.001), inter-observer reproducibility (p < 0.001) and inter-study reproducibility (p < 0.001). The variability is also lower for DB sequences for T2* values <14 ms. Assessment of artifacts showed a superior score for DB versus BB scans (4 versus 3, p < 0.001). Conclusions: Improvement in terms of inter observer and inter study variability using DB sequences was obtained. The greatest disparity between them was seen in inter-study reproducibility and higher IQ in DB was seen. Study demonstrates better performance of DB imaging compared to BB in presence of comparable effectiveness.

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.

OpenAIRE

Forsberg, K; Valyi-Nagy, I; Heldin, C H; Herlyn, M; Westermark, B

1993-01-01

Human WM9 melanoma cells, previously shown to be devoid of PDGF expression, were stably transfected with a PDGF-B cDNA under the transcriptional control of a cytomegalovirus promoter. Northern blot analysis revealed high expression of an mRNA of the expected size in the PDGF-B-transfected cells. Synthesis and secretion of PDGF-BB was confirmed by immunoprecipitation. Furthermore, conditioned medium from PDGF-B-transfected cells contained a mitogenic activity for fibroblasts. For analysis of t...

Inflows, Outflows, and a Giant Donor in the Remarkable Recurrent Nova M31N 2008-12a?-Hubble Space Telescope Photometry of the 2015 Eruption

Czech Academy of Sciences Publication Activity Database

Darnley, M.J.; Hounsell, R.; Godon, M.; Perley, D.A.; Henze, M.; Kuindersma, S.; Williams, B. F.; Williams, S.C.; Bode, M.F.; Harman, D. J.; Hornoch, Kamil; Link, M.; Ness, J.-U.; Ribeiro, V.A.R.M.; Sion, E. M.; Shafter, A.W.; Shara, M. M.

2017-01-01

Roč. 849, č. 2 (2017), 96/1-96/17 ISSN 0004-637X Institutional support: RVO:67985815 Keywords : accretion * accretion disks * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics OBOR OECD: Astronomy (including astrophysics,space science) Impact factor: 5.533, year: 2016

Interacting binaries

CERN Document Server

Shore, S N; van den Heuvel, EPJ

1994-01-01

This volume contains lecture notes presented at the 22nd Advanced Course of the Swiss Society for Astrophysics and Astronomy. The contributors deal with symbiotic stars, cataclysmic variables, massive binaries and X-ray binaries, in an attempt to provide a better understanding of stellar evolution.

Seasonal variability of the parameters of the Ball-Berry model of stomatal conductance in maize (Zea mays L.) and sunflower (Helianthus annuus L.) under well-watered and water-stressed conditions.

Science.gov (United States)

Miner, Grace L; Bauerle, William L

2017-09-01

The Ball-Berry (BB) model of stomatal conductance (g s ) is frequently coupled with a model of assimilation to estimate water and carbon exchanges in plant canopies. The empirical slope (m) and 'residual' g s (g 0 ) parameters of the BB model influence transpiration estimates, but the time-intensive nature of measurement limits species-specific data on seasonal and stress responses. We measured m and g 0 seasonally and under different water availability for maize and sunflower. The statistical method used to estimate parameters impacted values nominally when inter-plant variability was low, but had substantial impact with larger inter-plant variability. Values for maize (m = 4.53 ± 0.65; g 0  = 0.017 ± 0.016 mol m -2 s -1 ) were 40% higher than other published values. In maize, we found no seasonal changes in m or g 0 , supporting the use of constant seasonal values, but water stress reduced both parameters. In sunflower, inter-plant variability of m and g 0 was large (m = 8.84 ± 3.77; g 0  = 0.354 ± 0.226 mol m -2 s -1 ), presenting a challenge to clear interpretation of seasonal and water stress responses - m values were stable seasonally, even as g 0 values trended downward, and m values trended downward with water stress while g 0 values declined substantially. © 2017 John Wiley & Sons Ltd.

Measurement of Inclusive Ds, D0, and J/ψ Rates and Determination of the Bs(*)Bs(*) Production Fraction in bb Events at the Υ(5S) Resonance

International Nuclear Information System (INIS)

Drutskoy, A.; Goldenzweig, P.; Kinoshita, K.; Kulasiri, R.; Schwartz, A. J.; Somov, A.; Abe, K.; Adachi, I.; Dragic, J.; Gershon, T.; Haba, J.; Hazumi, M.; Higuchi, T.; Itoh, R.; Iwasaki, Y.; Katayama, N.; Kichimi, H.; Krokovny, P.; Limosani, A.; Nakao, M.

2007-01-01

The inclusive production of D s , D 0 , and J/ψ mesons is studied using a 1.86 fb -1 data sample collected on the Υ(5S) resonance with the Belle detector at the KEKB asymmetric-energy e + e - collider. The number of bb events in this Υ(5S) data sample is determined. We measure the branching fractions B(Υ(5S)→D s X)/2=(23.6±1.2±3.6)%, B(Υ(5S)→D 0 X)/2=(53.8±2.0±3.4)%, and B(Υ(5S)→J/ψX)/2=(1.030±0.080±0.067)%. From the D s and D 0 inclusive branching fractions the ratio f s =(18.0±1.3±3.2)% of B s (*) B s (*) to the total bb quark pair production at the Υ(5S) energy is obtained in a model-dependent way

Assimilable organic carbon (AOC) in soil water extracts using Vibrio harveyi BB721 and its implication for microbial biomass.

Science.gov (United States)

Ma, Jincai; Ibekwe, A Mark; Wang, Haizhen; Xu, Jianming; Leddy, Menu; Yang, Ching-Hong; Crowley, David E

2012-01-01

Assimilable organic carbon (AOC) is commonly used to measure the growth potential of microorganisms in water, but has not yet been investigated for measuring microbial growth potential in soils. In this study, a simple, rapid, and non-growth based assay to determine AOC in soil was developed using a naturally occurring luminous strain Vibrio harveyi BB721 to determine the fraction of low molecular weight organic carbon in soil water extract. Calibration of the assay was achieved by measuring the luminescence intensity of starved V. harveyi BB721 cells in the late exponential phase with a concentration range from 0 to 800 µg l(-1) glucose (equivalent to 0-16.0 mg glucose C kg(-1) soil) with the detection limit of 10 µg l(-1) equivalent to 0.20 mg glucose C kg(-1) soil. Results showed that bioluminescence was proportional to the concentration of glucose added to soil. The luminescence intensity of the cells was highly pH dependent and the optimal pH was about 7.0. The average AOC concentration in 32 soils tested was 2.9±2.2 mg glucose C kg(-1). Our data showed that AOC levels in soil water extracts were significantly correlated (Pgrowth bioluminescence based assay. Understanding the levels of AOC in soil water extract provides new insights into our ability to estimate the most available carbon pool to bacteria in soil that may be easily assimilated into cells for many metabolic processes and suggest possible the links between AOC, microbial regrowth potential, and microbial biomass in soils.

A remarkable recurrent nova in M 31: The optical observations

Czech Academy of Sciences Publication Activity Database

Darnley, M.J.; Williams, S.C.; Bode, M.F.; Henze, M.; Ness, J.-U.; Shafter, A.W.; Hornoch, Kamil; Votruba, Viktor

2014-01-01

Roč. 563, March (2014), L9/1-L9/4 ISSN 0004-6361 R&D Projects: GA MŠk LG12001 Institutional support: RVO:67985815 Keywords : galaxies: individual: M 31 * novae * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.378, year: 2014

Evolution of the optical and hard X-ray activity of AM Her in a season dominated by the high states

Czech Academy of Sciences Publication Activity Database

Šimon, Vojtěch

2016-01-01

Roč. 361, č. 7 (2016), 235/1-235/8 ISSN 0004-640X Grant - others:GAO(CZ) GC13-39464J Institutional support: RVO:67985815 Keywords : X-rays binaries * cataclysmic variables * radiation mechanisms Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.622, year: 2016

Observations of TT Ari requested in support of MOST observations

Science.gov (United States)

Waagen, Elizabeth O.

2012-08-01

Dr. Nikolaus Vogt (Universidad de Valparaiso, Chile) requested simultaneous photometry and spectroscopy of the novalike (VY Scl subtype) cataclysmic variable TT Ari in support of upcoming observations with the Canadian Microvariability and Oscillations of Stars (MOST) satellite 2012 September 13 through October 20. The Departamento de Fisica y Astronomia of the Valparaiso University will carry out photometry with small telescopes in central Chile but the assistance of other observers, particularly in other latitudes and longitudes, is requested. The observations are being carried out to study superhump behavior, which is still not well understood despite the amount of research done in all classes of cataclysmic variables. TT Ari exibits superhumps - both positive (the superhump period is longer than the orbital period) and negative (the superhump period is shorter than the orbital period). While positive superhumps are thought probably to be the result of an eccentric configuration in the accretion disk, the mechanism for negative superhumps is not yet understood except that it may be related to the disk's being warped out of the orbital plane, leading to complex torque phenomena. TT Ari, one of the brightest cataclysmic variables, exhibits occasional fadings of several magnitudes, from its usual high-state (maximum) magnitude of ~10.5V to a low-state magnitude as faint as 16V. These fadings occur every 20-25 years, and last between 500 and 1000 days. According to observations in the AAVSO International Database, TT Ari is currently magnitude 10.5V. Finder charts with sequence may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details, particularly regarding goals of the campaign, and observing instructions.

On the SW Sex-type eclipsing cataclysmic variable SDSS0756+0858

Energy Technology Data Exchange (ETDEWEB)

Tovmassian, Gagik; Hernandez, Mercedes Stephania; González-Buitrago, Diego; Zharikov, Sergey; García-Díaz, Maria Teresa, E-mail: gag@astro.unam.mx [Instituto de Astronomía, Universidad Nacional Autonoma de México, Apdo. Postal 877, Ensenada, Baja California 22800 (Mexico)

2014-03-01

We conducted a spectroscopic and photometric study of SDSS J075653.11+085831. X-ray observations were also attempted. We determined the orbital period of this binary system to be 3.29 hr. It is a deep eclipsing system, whose spectra show mostly single-peaked, Balmer emission lines and a rather intense He II line. There is also the presence of faint (often double-peaked) He I emission lines as well as several absorption lines, Mg I being the most prominent. All of these features point toward the affiliation of this object with the growing number of SW Sex-type objects. We developed a phenomenological model of an SW Sex system to reproduce the observed photometric and spectral features.

On the SW Sex-type eclipsing cataclysmic variable SDSS0756+0858

International Nuclear Information System (INIS)

Tovmassian, Gagik; Hernandez, Mercedes Stephania; González-Buitrago, Diego; Zharikov, Sergey; García-Díaz, Maria Teresa

2014-01-01

We conducted a spectroscopic and photometric study of SDSS J075653.11+085831. X-ray observations were also attempted. We determined the orbital period of this binary system to be 3.29 hr. It is a deep eclipsing system, whose spectra show mostly single-peaked, Balmer emission lines and a rather intense He II line. There is also the presence of faint (often double-peaked) He I emission lines as well as several absorption lines, Mg I being the most prominent. All of these features point toward the affiliation of this object with the growing number of SW Sex-type objects. We developed a phenomenological model of an SW Sex system to reproduce the observed photometric and spectral features.

Rapid oscillations in cataclysmic variables. VI. Periodicities in erupting dwarf novae

International Nuclear Information System (INIS)

Patterson, J.

1981-01-01

We report an extensive study of the coherent oscillations observed in high-speed photometry of dwarf novae during eruption. The oscillations are in all cases singly periodic and sinusoidal to the limits of measurement. The detection of oscillations in 14 separate eruptions of AH Her and SY Cnc enables a general study of period variations. The stars trace out characteristic loops (''banana diagrams'') in the period-intensity plane. New detections are also reported for SS Cyg, EM Cyg, and HT Cas

Mass loss from interacting close binary systems

Science.gov (United States)

Plavec, M. J.

1981-01-01

The three well-defined classes of evolved binary systems that show evidence of present and/or past mass loss are the cataclysmic variables, the Algols, and Wolf-Rayet stars. It is thought that the transformation of supergiant binary systems into the very short-period cataclysmic variables must have been a complex process. The new evidence that has recently been obtained from the far ultraviolet spectra that a certain subclass of the Algols (the Serpentids) are undergoing fairly rapid evolution is discussed. It is thought probable that the remarkable mass outflow observed in them is connected with a strong wind powered by accretion. The origin of the circumbinary clouds or flat disks that probably surround many strongly interacting binaries is not clear. Attention is also given to binary systems with hot white dwarf or subdwarf components, such as the symbiotic objects and the BQ stars; it is noted that in them both components may be prone to an enhanced stellar wind.

X-ray and optical observations of the ultrashort period dwarf nova SW Ursae Majoris - A likely new DQ Herculis star

Science.gov (United States)

Shafter, A. W.; Szkody, P.; Thorstensen, J. R.

1986-01-01

Time-resolved X-ray and optical photometric and optical spectroscopic observations of the ultrashort period cataclysmic variable SW UMa are reported. The spectroscopic observations reveal the presence of an s-wave component which is almost in phase with the extreme line wings and presumably the white dwarf. This very unusual phasing in conjunction with the available optical and X-ray data seems to indicate that a region of enhanced emission exists on the opposite side of the disk from the expected location of the hot spot. The photometric observations reveal the presence of a hump in the light curve occurring at an orbital phase which is consistent with the phase at which the region of enhanced line emission is most favorably seen. Changes in the hump amplitude are seen from night to night, and a 15.9 min periodicity is evident in the light curve. The optical and X-ray periodicities suggest that SW UMa is a member of the DQ Her class of cataclysmic variables.

Disturbed zone modelling SVC validation drift using UDEC-BB, models 1 to 8 - Stripa phase 3

International Nuclear Information System (INIS)

Monsen, K.; Makurat, A.; Barton, N.

1991-01-01

Several rock mechanics studies were performed within the site characterization and validation (SCV) project at Stripa. Joints represented in Harwell's stochastically generated 8m x 8m x 8m cubes were used to select four possible joints geometries for two-dimensional rock mechanics simulations of the 2.8 x 2.2 m validation drift, and the rock mass response to its excavation. The joints intersecting the four end faces of these cubes were set up in distinct element UDEC-BB models, and loaded with boundary stresses of 10 MPa vertically and 14 to 18 MPa horizontally. In numerical models 1, 2, 3 and 4 average values of the Barton Bandis joint parameters JRC, JCS and φ r were utilized for all joints, irrespective of length. These values were obtained from NGI's index characterization of 220 joints in 100 mm core and from 200 mm diameter and 1 x 1 2m block testing were coupled closure-shear-flow testing (CSFT) was also performed. In numerical models 5, 6, 7, 8 the same joint geometries were utilized with length-dependent values of JRC, JCS and φ r . The longest joints were given low values representing mineralized persistent discontinuities, while the shortest joints were given high values. Detailed analyses were made of the tangential and radial stress magnitudes that were obtained in the four UDEC-BB discontinuum models 5, 6, 7 and 8. Results were presented for all sectors of the models as a function of radius from the drift walls. These stress magnitudes were compared with those from an equivalent continuum model which showed, as expected, much more predictable stress gradients. Modelled drift closures ranged from 2 to 3 mm in the jointed models and from 1 to 1.5 mm in the continuum model. Local tensile stress development maximum 28 MPa, and local shearing of individual joints, maximum 1.0 mm, were a feature of the jointed models. Peak tangential stresses locally reached 54 to 74 MPa in the jointed models compared to 43 MPa in the continuum model. (au)

Late Pleistocene-Holocene cataclysmic eruptions at Nevado de Toluca and Jocotitlan volcanoes, central Mexico

Science.gov (United States)

Macias, J.L.; Garcia, P.A.; Arce, J.L.; Siebe, C.; Espindola, J.M.; Komorowski, J.C.; Scott, K.

1997-01-01

This field guide describes a five day trip to examine deposits of Late Pleistocene-Holocene cataclysmic eruptions at Nevado de Toluca and Jocotitlan volcanoes in central Mexico. We will discuss the stratigraphy, petrology, and sedimentological characteristics of these deposits which provide insights into the eruptive history, type of volcanic activity, and transport and emplacement mechanisms of pyroclastic materials. These parameters will allow us to discuss the kinds of hazards and the risk that they pose to populations around these volcanoes. The area to be visited is tectonically complex thus we will also discuss the location of the volcanoes with respect to the tectonic environment. The first four days of the field trip will be dedicated to Nevado de Toluca Volcano (19 degrees 09'N; 99 degrees 45'W) located at 23 km. southwest of the City of Toluca, and is the fourth highest peak in the country, reaching an elevation of 4,680 meters above sea level (m.a.s.l.). Nevado de Toluca is an andesitic-dacitic stratovolcano, composed of a central vent excavated upon the remains of older craters destroyed by former events. Bloomfield and Valastro, (1974, 1977) concluded that the last cycle of activity occurred nearly equal 11,600 yr. ago. For this reason Nevado de Toluca has been considered an extinct volcano. Our studies, however, indicate that Nevado de Toluca has had at least two episodes of cone destruction by sector collapse as well as several explosive episodes including plinian eruptions and dome-destruction events. These eruptions occurred during the Pleistocene but a very young eruption characterized by surge and ash flows occurred ca. 3,300 yr. BP. This new knowledge of the volcano's eruptive history makes the evaluation of its present state of activity and the geological hazards necessary. This is important because the area is densely populated and large cities such as Toluca and Mexico are located in its proximity.

The spectroscopic evolution of the symbiotic-like recurrent nova V407 Cygni during its 2010 outburst

Czech Academy of Sciences Publication Activity Database

Shore, S. N.; Wahlgren, G.M.; Augusteijn, T.; Liimets, T.; Page, K.L.; Osborne, J.P.; Beardmore, A.P.; Koubský, Pavel; Šlechta, Miroslav; Votruba, Viktor

2011-01-01

Roč. 527, March (2011), A98/1-A98/15 ISSN 0004-6361 Grant - others:EU(XE) ESA PECS project No 98058. Institutional research plan: CEZ:AV0Z10030501 Keywords : novae * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.587, year: 2011

Assessment of Inheritance and Fitness Costs Associated with Field-Evolved Resistance to Cry3Bb1 Maize by Western Corn Rootworm.

Science.gov (United States)

Paolino, Aubrey R; Gassmann, Aaron J

2017-05-11

The western corn rootworm, Diabrotica virgifera virgifera LeConte, is among the most serious insect pests of maize in North America. One strategy used to manage this pest is transgenic maize that produces one or more crystalline (Cry) toxins derived from the bacterium Bacillus thuringiensis (Bt). To delay Bt resistance by insect pests, refuges of non-Bt maize are grown in conjunction with Bt maize. Two factors influencing the success of the refuge strategy to delay resistance are the inheritance of resistance and fitness costs, with greater delays in resistance expected when inheritance of resistance is recessive and fitness costs are present. We measured inheritance and fitness costs of resistance for two strains of western corn rootworm with field-evolved resistance to Cry3Bb1 maize. Plant-based and diet-based bioassays revealed that the inheritance of resistance was non-recessive. In a greenhouse experiment, in which larvae were reared on whole maize plants in field soil, no fitness costs of resistance were detected. In a laboratory experiment, in which larvae experienced intraspecific and interspecific competition for food, a fitness cost of delayed larval development was identified, however, no other fitness costs were found. These findings of non-recessive inheritance of resistance and minimal fitness costs, highlight the potential for the rapid evolution of resistance to Cry3Bb1 maize by western corn rootworm, and may help to improve resistance management strategies for this pest.

Assessment of Inheritance and Fitness Costs Associated with Field-Evolved Resistance to Cry3Bb1 Maize by Western Corn Rootworm

Directory of Open Access Journals (Sweden)

Aubrey R. Paolino

2017-05-01

Full Text Available The western corn rootworm, Diabrotica virgifera virgifera LeConte, is among the most serious insect pests of maize in North America. One strategy used to manage this pest is transgenic maize that produces one or more crystalline (Cry toxins derived from the bacterium Bacillus thuringiensis (Bt. To delay Bt resistance by insect pests, refuges of non-Bt maize are grown in conjunction with Bt maize. Two factors influencing the success of the refuge strategy to delay resistance are the inheritance of resistance and fitness costs, with greater delays in resistance expected when inheritance of resistance is recessive and fitness costs are present. We measured inheritance and fitness costs of resistance for two strains of western corn rootworm with field-evolved resistance to Cry3Bb1 maize. Plant-based and diet-based bioassays revealed that the inheritance of resistance was non-recessive. In a greenhouse experiment, in which larvae were reared on whole maize plants in field soil, no fitness costs of resistance were detected. In a laboratory experiment, in which larvae experienced intraspecific and interspecific competition for food, a fitness cost of delayed larval development was identified, however, no other fitness costs were found. These findings of non-recessive inheritance of resistance and minimal fitness costs, highlight the potential for the rapid evolution of resistance to Cry3Bb1 maize by western corn rootworm, and may help to improve resistance management strategies for this pest.

Effect of yoghurt containing Bifidobacterium lactis Bb12® on faecal excretion of secretory immunoglobulin A and human beta-defensin 2 in healthy adult volunteers

Directory of Open Access Journals (Sweden)

Kabeerdoss Jayakanthan

2011-12-01

Full Text Available Abstract Background Probiotics are used to provide health benefits. The present study tested the effect of a probiotic yoghurt on faecal output of beta-defensin and immunoglobulin A in a group of young healthy women eating a defined diet. Findings 26 women aged 18-21 (median 19 years residing in a hostel were given 200 ml normal yoghurt every day for a week, followed by probiotic yoghurt containing Bifidobacterium lactis Bb12® (109 in 200 ml for three weeks, followed again by normal yoghurt for four weeks. Stool samples were collected at 0, 4 and 8 weeks and assayed for immunoglobulin A and human beta-defensin-2 by ELISA. All participants tolerated both normal and probiotic yoghurt well. Human beta-defensin-2 levels in faeces were not altered during the course of the study. On the other hand, compared to the basal sample, faecal IgA increased during probiotic feeding (P = 0.0184 and returned to normal after cessation of probiotic yoghurt intake. Conclusions Bifidobacterium lactis Bb12® increased secretory IgA output in faeces. This property may explain the ability of probiotics to prevent gastrointestinal and lower respiratory tract infections.

General Relativity Theory Explains the Shnoll Effect and Makes Possible Forecasting Earthquakes and Weather Cataclysms (Letters to Progress in Physics

Directory of Open Access Journals (Sweden)

Rabounski D.

2014-04-01

Full Text Available The Shnoll effect manifests itself in the fine structure of the noise registered in very sta- ble processes, where the magnitude of signal and the average noise remain unchanged. It is found in the periodic fluctuation of the fine structure of the noise according to the cosmic cycles connected with stars, the Sun, and the Moon. Th e Shnoll effect is ex- plained herein, employing the framework of General Relativity, as the twin / entangled synchronization states of the observer’s reference frame. The states are repeated while the observer travels, in common with the Earth, through the c osmic grid of the geodesic synchronization paths that connect his local reference fra me with the reference frames of other cosmic bodies. These synchronization periods matc h the periods that are man- ifested due to the Shnoll e ff ect, regardless of which process produces the noise. These synchronization periods are expected to exist in the noise o f natural processes of any type (physics, biology, social, etc. as well as in such arti ficial processes as computer- software random-number generation. This conclusion accor ds with what was registered according the Shnoll effect. The theory not only explains the Shnoll effect but also al- lows for forecasting fluctuations in the stock exchange mark et, fluctuations of weather, earthquakes, and other cataclysms.

First search for boosted Higgs boson production using the H->bb decay with CMS

CERN Multimedia

CERN. Geneva

2017-01-01

An inclusive search for the standard model Higgs boson produced with high transverse momentum decaying to a bottom-antibottom quark pair has been performed using a data set of pp collisions at √s = 13 TeV collected with the CMS experiment at LHC. The data sample corresponds to an integrated luminosity of 35.9 fb−1. High-transverse-momentum Higgs bosons are reconstructed in a single jet with radius R = 0.8. Jet substructure and dedicated b-tagging techniques are used to identify boosted H → bb. The resulting experimental signature is a peak over a falling background in the distribution of the invariant mass of the jet. The Z process validates the analysis strategy and is observed with a local significance of 5.1 standard deviations for the first time in the single jet topology. An excess of events is observed above the expected background with a local significance of 1.3 standard deviations for a Higgs boson mass of 125 GeV. The signal strength corresponding to this excess, relative to that of the standa...

Viability of Lactobacillus acidophilus LA-5 and Bifidobacterium bifidum BB-12 in Rice Pudding

Directory of Open Access Journals (Sweden)

Tulay Ozcan

2010-06-01

Full Text Available The purpose of this study was to determine the survival of two probiotic micro-organisms (Lactobacillus acidophilus LA-5 and Bifidobacterium bifidum BB-12 in a rice pudding, the impact of these bacteria on hygienic quality, and to verify the perspectives of the product with regard to consumer sensorial acceptance. The products were monitored for the microbial population, pH, titratable acidity and consistency, during storage at 4±1 °C for up to 21 days. Sensory preference was also tested. Even though the viability of the probiotic bacteria was reduced over 21 days of storage, the viable cell concentrations were still sufficient to obtain the desired therapeutic impact. The counts of yeasts-moulds and Staphylococcus spp. decreased in samples with added probiotic bacteria. The sensorial properties of probiotic rice pudding demonstrated similar acceptability to the control up to 14 days and declined thereafter. Rice pudding was considered suitable food for the delivery of probiotic micro-organisms, with sufficient viability and acceptable sensory characteristics.

Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a study protocol for a randomised controlled trial.

Science.gov (United States)

Lee, Bonsan Bonne; Toh, Swee-Ling; Ryan, Suzanne; Simpson, Judy M; Clezy, Kate; Bossa, Laetitia; Rice, Scott A; Marial, Obaydullah; Weber, Gerard; Kaur, Jasbeer; Boswell-Ruys, Claire; Goodall, Stephen; Middleton, James; Tudehope, Mark; Kotsiou, George

2016-04-16

Urinary tract infections [UTIs] are very common in people with Spinal Cord Injury [SCI]. UTIs are increasingly difficult and expensive to treat as the organisms that cause them become more antibiotic resistant. Among the SCI population, there is a high rate of multi-resistant organism [MRO] colonisation. Non-antibiotic prevention strategies are needed to prevent UTI without increasing resistance. Probiotics have been reported to be beneficial in preventing UTIs in post-menopausal women in several in vivo and in vitro studies. The main aim of this study is to determine whether probiotic therapy with combinations of Lactobacillus reuteri RC-14 + Lactobacillus rhamnosus GR-1 [RC14-GR1] and/or Lactobacillus rhamnosus GG + Bifidobacterium BB-12 [LGG-BB12] are effective in preventing UTI in people with SCI compared to placebo. This is a multi-site randomised double-blind double-dummy placebo-controlled factorial design study conducted in New South Wales, Australia. All participants have a neurogenic bladder as a result of spinal injury. Recruitment started in April 2011. Participants are randomised to one of four arms, designed for factorial analysis of LGG-BB12 and/or RC14-GR1 v Placebo. This involves 24 weeks of daily oral treatment with RC14-GR1 + LGG-BB12, RC14-GR1 + placebo, LGG-BB12 + placebo or two placebo capsules. Randomisation is stratified by bladder management type and inpatient status. Participants are assessed at baseline, three months and six months for Short Form Health Survey [SF-36], microbiological swabs of rectum, nose and groin; urine culture and urinary catheters for subjects with indwelling catheters. A bowel questionnaire is administered at baseline and three months to assess effect of probiotics on bowel function. The primary outcome is time from randomisation to occurrence of symptomatic UTI. The secondary outcomes are change of MRO status and bowel function, quality of life and cost-effectiveness of probiotics in persons

Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135.

Science.gov (United States)

De Luca, Maria Antonietta; Castelli, M Paola; Loi, Barbara; Porcu, Alessandra; Martorelli, Mariella; Miliano, Cristina; Kellett, Kathryn; Davidson, Colin; Stair, Jacqueline L; Schifano, Fabrizio; Di Chiara, Gaetano

2016-06-01

In order to investigate the in vivo dopamine (DA) stimulant properties of selected 3rd generation Spice/K2 cannabinoids, BB-22, 5F-PB-22, 5F-AKB-48 and STS-135, their in vitro affinity and agonist potency at native rat and mice CB1 receptors was studied. The compounds bind with high affinity to CB1 receptors in rat cerebral cortex homogenates and stimulate CB1-induced [(35)S]GTPγS binding with high potency and efficacy. BB-22 and 5F-PB-22 showed the lowest Ki of binding to CB1 receptors (0.11 and 0.13 nM), i.e., 30 and 26 times lower respectively than that of JWH-018 (3.38 nM), and a potency (EC50, 2.9 and 3.7 nM, respectively) and efficacy (Emax, 217% and 203%, respectively) as CB1 agonists higher than JWH-018 (EC50, 20.2 nM; Emax, 163%). 5F-AKB-48 and STS-135 had higher Ki for CB1 binding, higher EC50 and lower Emax as CB1 agonists than BB-22 and 5F-PB-22 but still comparatively more favourable than JWH-018. The agonist properties of all the compounds were abolished or drastically reduced by the CB1 antagonist/inverse agonist AM251 (0.1 μM). No activation of G-protein was observed in CB1-KO mice. BB-22 (0.003-0.01 mg/kg i.v.) increased dialysate DA in the accumbens shell but not in the core or in the medial prefrontal cortex, with a bell shaped dose-response curve and an effect at 0.01 mg/kg and a biphasic time-course. Systemic AM251 (1.0 mg/kg i.p.) completely prevented the stimulant effect of BB-22 on dialysate DA in the NAc shell. All the other compounds increased dialysate DA in the NAc shell at doses consistent with their in vitro affinity for CB1 receptors (5F-PB-22, 0.01 mg/kg; 5F-AKB-48, 0.1 mg/kg; STS-135, 0.15 mg/kg i.v.). 3rd generation cannabinoids can be even more potent and super-high CB1 receptor agonists compared to JWH-018. Future research will try to establish if these properties can explain the high toxicity and lethality associated with these compounds. Copyright © 2015 Elsevier Ltd. All rights reserved.

Long-term activity of QU Car

Czech Academy of Sciences Publication Activity Database

Šimon, Vojtěch

2017-01-01

Roč. 338, č. 6 (2017), s. 696-699 ISSN 0004-6337 Grant - others:GA ČR(CZ) GA13-33324S Institutional support: RVO:67985815 Keywords : novae * cataclysmic variables * accretion disks Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics OBOR OECD: Astronomy (including astrophysics,space science) Impact factor: 0.916, year: 2016

Photometry of the three eclipsing novalike variables EC 21178-5417, GS Pav and V345 Pav

Science.gov (United States)

Bruch, Albert

2017-10-01

As part of a project to better characterize comparatively bright, yet little studied cataclysmic variables time resolved photometry of the three eclipsing novalike variables EC 21178-5417, GS Pav und V345 Pav is presented. Previously known orbital periods are significantly improved and long-term ephemeris are derived. Variations of eclipse profiles, occurring on time scales of days to weeks, are analyzed. Out of eclipse the light curves are characterized by low scale flickering superposed on more gradual variations with amplitudes limited to a few tenths of a magnitude and profiles which at least in EC 21178-5417 and GS Pav roughly follow the same pattern in all observed cycles. Additionally, signs for variations on the time scale of some tens of minutes are seen in GS Pav, most clearly in two subsequent nights when in the first of these a signal with a period of 15.7 min was observed over several hours. In the second night variations with twice this period were seen. While no additional insight could be gained on quasi periodic oscillations (QPOs) and dwarf nova oscillations in EC 21178-5417, previously detected by Warner et al. (2003), and while such oscillations could not be found in V345 Pav, stacked power spectra of GS Pav clearly reveal the presence of QPOs over time intervals of several hours with periods varying between 200 s and 500 s in that system.

Assimilable organic carbon (AOC in soil water extracts using Vibrio harveyi BB721 and its implication for microbial biomass.

Directory of Open Access Journals (Sweden)

Jincai Ma

Full Text Available Assimilable organic carbon (AOC is commonly used to measure the growth potential of microorganisms in water, but has not yet been investigated for measuring microbial growth potential in soils. In this study, a simple, rapid, and non-growth based assay to determine AOC in soil was developed using a naturally occurring luminous strain Vibrio harveyi BB721 to determine the fraction of low molecular weight organic carbon in soil water extract. Calibration of the assay was achieved by measuring the luminescence intensity of starved V. harveyi BB721 cells in the late exponential phase with a concentration range from 0 to 800 µg l(-1 glucose (equivalent to 0-16.0 mg glucose C kg(-1 soil with the detection limit of 10 µg l(-1 equivalent to 0.20 mg glucose C kg(-1 soil. Results showed that bioluminescence was proportional to the concentration of glucose added to soil. The luminescence intensity of the cells was highly pH dependent and the optimal pH was about 7.0. The average AOC concentration in 32 soils tested was 2.9±2.2 mg glucose C kg(-1. Our data showed that AOC levels in soil water extracts were significantly correlated (P<0.05 with microbial biomass determined as microbial biomass carbon, indicating that the AOC concentrations determined by the method developed might be a good indicator of soil microbial biomass. Our findings provide a new approach that may be used to determine AOC in environmental samples using a non-growth bioluminescence based assay. Understanding the levels of AOC in soil water extract provides new insights into our ability to estimate the most available carbon pool to bacteria in soil that may be easily assimilated into cells for many metabolic processes and suggest possible the links between AOC, microbial regrowth potential, and microbial biomass in soils.

Search for Higgs pair-production in the bb$\\tau$$\\tau$ final state with the ATLAS detector

CERN Document Server

Saha, Puja

2016-01-01

We present the result of Higgs boson pair production and subsequent decay into the bbττ channel in pp collision at centre-of-mass energy of 8 TeV using the ATLAS detector at the LHC. This analysis is based on the full 2012 data corresponding to a total luminosity of 20.3 fb−1 . We have explored resonant and non-resonant production of Higgs pair in the final state where one τ decays leptonically and the other hadronically. The observed upper limit at 95% CL on the cross-section σ (gg → hh) is found to be 1.6 pb for non-resonant production. For resonant production the observed limit ranges between 4.2 pb for mH = 260 GeV and 0.46 pb for mH = 1000 GeV. H is the heavy scalar, which decays to two Standard-Model-like Higgs, h.

Combined search for the standard model Higgs boson decaying to a bb pair using the full CDF data set.

Science.gov (United States)

Aaltonen, T; Álvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Bae, T; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M E; Bisello, D; Bizjak, I; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brigliadori, L; Bromberg, C; Brucken, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Calamba, A; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chung, W H; Chung, Y S; Ciocci, M A; Clark, A; Clarke, C; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuevas, J; Culbertson, R; Dagenhart, D; d'Ascenzo, N; Datta, M; de Barbaro, P; Dell'Orso, M; Demortier, L; Deninno, M; Devoto, F; d'Errico, M; Di Canto, A; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, M; Dorigo, T; Ebina, K; Elagin, A; Eppig, A; Erbacher, R; Errede, S; Ershaidat, N; Eusebi, R; Farrington, S; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Funakoshi, Y; Furic, I; Gallinaro, M; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldin, D; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Grinstein, S; Grosso-Pilcher, C; Group, R C; Guimaraes da Costa, J; Hahn, S R; Halkiadakis, E; Hamaguchi, A; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Hewamanage, S; Hocker, A; Hopkins, W; Horn, D; Hou, S; Hughes, R E; Hurwitz, M; Husemann, U; Hussain, N; Hussein, M; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeans, D T; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kim, Y J; Kimura, N; Kirby, M; Klimenko, S; Knoepfel, K; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Kruse, M; Krutelyov, V; Kuhr, T; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; LeCompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leo, S; Leone, S; Lewis, J D; Limosani, A; Lin, C-J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, H; Liu, Q; Liu, T; Lockwitz, S; Loginov, A; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Madrak, R; Maeshima, K; Maestro, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Martínez, M; Mastrandrea, P; Matera, K; Mattson, M E; Mazzacane, A; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Noh, S Y; Norniella, O; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Poprocki, S; Potamianos, K; Prokoshin, F; Pranko, A; Ptohos, F; Punzi, G; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Rescigno, M; Riddick, T; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Safonov, A; Sakumoto, W K; Sakurai, Y; Santi, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shochet, M; Shreyber-Tecker, I; Simonenko, A; Sinervo, P; Sliwa, K; Smith, J R; Snider, F D; Soha, A; Sorin, V; Song, H; Squillacioti, P; Stancari, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Tipton, P; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Ukegawa, F; Uozumi, S; Varganov, A; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vizán, J; Vogel, M; Volpi, G; Wagner, P; Wagner, R L; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Wester, W C; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Wick, F; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamato, D; Yang, T; Yang, U K; Yang, Y C; Yao, W-M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhou, C; Zucchelli, S

2012-09-14

We combine the results of searches for the standard model (SM) Higgs boson based on the full CDF Run II data set obtained from sqrt[s]=1.96  TeV pp collisions at the Fermilab Tevatron corresponding to an integrated luminosity of 9.45  fb(-1). The searches are conducted for Higgs bosons that are produced in association with a W or Z boson, have masses in the range 90-150  GeV/c(2), and decay into bb pairs. An excess of data is present that is inconsistent with the background prediction at the level of 2.5 standard deviations (the most significant local excess is 2.7 standard deviations).

New stars for old

International Nuclear Information System (INIS)

Henbest, N.

1980-01-01

Observations of novas made through the ages, the identity of the close double stars which make up these cataclysmic variables and the physics of nova explosions, are discussed. A picture is outlined which explains novas, dwarf novas and recurrent novas and provides a basis for interpreting the latest so called x-ray novas. (U.K.)

The BINSYN Program Package

Directory of Open Access Journals (Sweden)

Albert P. Linnell

2012-06-01

Full Text Available The BINSYN program package, recently expanded to calculate synthetic spectra of cataclysmic variables, is being further extended to include synthetic photometry of ordinary binary stars in addition to binary stars with optically thick accretion disks. The package includes a capability for differentials correction optimization of eclipsing binary systems using synthetic photometry.

YY Sex: a Polar Candidate

Science.gov (United States)

Gabdeev, M. M.; Shimanskiy, V. V.; Borisov, N. V.; Tazieva, Z. R.

2017-06-01

We present spectroscopic investigations of a cataclysmic variable star, YY Sex. There are some uncertainties in the classification of this object. We calculate Doppler maps for Hβ and HeII λ4686Å and show that there is no sign of disk accretion in YY Sex. Consequently, we conclude that YY Sex is a polar.

Platelet glycoprotein IIb/IIIa polymorphism HPA-3 b/b is associated with increased risk of ischemic stroke in patients under 60 years of age.

Science.gov (United States)

Duan, Hao; Cai, Yan; Sun, Xiaojiang

2012-01-01

The role of genetic risk factors in ischemic stroke is unclear. Platelet glycoprotein IIb/IIIa (GpIIb-IIIa) has been implicated in the pathogenesis of ischemic stroke. We sought to evaluate the relationship between the GpIIb/IIIa complex gene polymorphism and ischemic stroke. We investigated the association of the GpIIb/IIIa complex gene polymorphism with stroke risk in 306 patients with acute ischemic stroke and 266 control subjects by determining the GpIIb and GpIIIa genotype from leukocyte DNA by polymerase chain reaction (PCR) followed by FokI and ScrFI digestion, respectively. Compared with controls, more patients presented with coronary heart disease, hypertension, smoking history, and diabetes. In addition, the patients had higher levels of cholesterol and glucose compared with the control subjects. All donors in the GpIIIa (n=572) group expressed the GpIIIa PlA1 (HPA-1 aa) phenotype. There were no significant differences between the HPA-3 genotype (GpIIb) patient distribution (aa=39.9%, ab=41.4%, bb=28.7%) and healthy control subjects (aa=36.1%, ab=35.0%, bb=28.9%) (P=0.580). Among study participants ischemic stroke >2-fold (P=0.008). The GpIIb Ile/Ser843 gene polymorphism is associated with ischemic stroke among young and middle-aged adults (ischemic stroke.

Search for the Higgs boson in the ZH → νν-bar bb-bar channel with the D0 experiment at the TeVatron

International Nuclear Information System (INIS)

Ochando, Ch.

2008-09-01

The origin of the electroweak symmetry breaking is one the pending questions at the beginning of the 21. century. Imagined in the 1960's, the Higgs mechanism offers a theoretical solution to this problem, while predicting a new particle, the Higgs boson, undiscovered up to now. This particle has been searched with the DO detector at the Tevatron hadronic collider, with a center of mass energy of 1,96 TeV. The analysis channel is ZH → νν-bar bb-bar. For this search, an optimization of the trigger conditions specific to signals with jets plus missing transverse energy final states has been performed. Moreover, a tool was designed to measure the corresponding efficiencies. A precise determination of the jet energies is also an essential ingredient for this analysis. A method was developed in order to correct the simulated jets for the differences observed in jet energy scale, energy resolution and reconstruction efficiency between data and simulation. The data analysis, performed with an integrated luminosity of 2.1 fb -1 , did not reveal any excess. For a Higgs boson mass of 115 GeV, a limit has been set at 95% C.L. on the cross section times branching fraction of (pp-barb → H(Z/W)) x (H → bar bb-bar), which is 7.5 times larger than the standard model value. (author)

VizieR Online Data Catalog: Radio observations of SN 2009bb (Soderberg+, 2010)

Science.gov (United States)

Soderberg, A. M.; Chakraborti, S.; Pignata, G.; Chevalier, R. A.; Chandra, P.; Ray, A.; Wieringa, M. H.; Copete, A.; Chaplin, V.; Connaughton, V.; Barthelmy, S. D.; Bietenholz, M. F.; Chugai, N.; Stritzinger, M. D.; Hamuy, M.; Fransson, C.; Fox, O.; Levesque, E. M.; Grindlay, J. E.; Challis, P.; Foley, R. J.; Kirshner, R. P.; Milne, P. A.; Torres, M. A. P.

2010-02-01

Long duration gamma-ray bursts (GRBs) mark the explosive death of some massive stars and are a rare sub-class of type Ibc supernovae. They are distinguished by the production of an energetic and collimated relativistic outflow powered by a central engine (an accreting black hole or neutron star). Observationally, this outflow is manifested in the pulse of gamma-rays and a long-lived radio afterglow. Until now, central-engine-driven supernovae have been discovered exclusively through their gamma-ray emission, yet it is expected that a larger population goes undetected because of limited satellite sensitivity or beaming of the collimated emission away from our line of sight. In this framework, the recovery of undetected GRBs may be possible through radio searches for type Ibc supernovae with relativistic outflows. Here we report the discovery of luminous radio emission from the seemingly ordinary type Ibc SN 2009bb, which requires a substantial relativistic outflow powered by a central engine. A comparison with our radio survey of type Ibc supernovae reveals that the fraction harbouring central engines is low, about one per cent, measured independently from, but consistent with, the inferred rate of nearby GRBs. Independently, a second mildly relativistic supernova has been reported. (1 data file).

Workshop on The Golden Age of Cataclysmic Variables and Related Objects - II .

Directory of Open Access Journals (Sweden)

Editorial, Foreword

2015-02-01

Full Text Available Organizing Institutions:INAF – Istituto di Astrofisica e Planetologia Spaziali, Roma – INAF-IAPS, Roma, ItalyINTA – Dpt. de Cargas Utiles y Ciencias del Espacio, INTA-DCUCE, Madrid, SpainCzech Republic Academy of Sciences – Astronomical Institute, ASCR-AI, Ondřejov, Czech RepublicCzech Technical University, CTU in Prague, Czech RepublicDepartment of Physics, Technion, Haifa, IsraelRussian Academy of Sciences – Institute of Astronomy, RAS-IA, Moscow, RussiaINAF - Osservatorio Astronomico di Capodimonte, INAF-OAC, Napoli, ItalyDepartment of Astronomy, University of Washington, Seattle, WA, USA

Lominous binary supersoft X-ray sources: optical colors and absolute magnitudes

Czech Academy of Sciences Publication Activity Database

Šimon, Vojtěch

2003-01-01

Roč. 406, č. 2 (2003), s. 613-621 ISSN 0004-6361 R&D Projects: GA AV ČR KSK1048102; GA ČR GA205/00/P013 Institutional research plan: CEZ:AV0Z1003909 Keywords : close star binaries * circumstellar matter * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 3.843, year: 2003

The dance of the double stars

International Nuclear Information System (INIS)

Theokas, A.

1985-01-01

The paper concerns pairs of stars orbiting one another. The evolutionary path model for close binary stars, involving a mass transfer of gases between the stars, is described. The life history of a single star; cataclysmic variables; the algol paradox, matter and lagranges' point; x-ray binaries and bursters; and pulsars; are all briefly discussed. (U.K.)

The classical nova outburst

International Nuclear Information System (INIS)

Starrfield, S.G.

1988-01-01

The classical nova outburst occurs on the white dwarf component in a close binary system. Nova systems are members of the general class of cataclysmic variables and other members of the class are the Dwarf Novae, AM Her variables, Intermediate Polars, Recurrent Novae, and some of the Symbiotic variables. Although multiwavelength observations have already provided important information about all of these systems, in this review I will concentrate on the outbursts of the classical and recurrent novae and refer to other members of the class only when necessary. 140 refs., 1 tab

ASAS-SN Discovery of a Possible Galactic Nova ASASSN-18ix

Science.gov (United States)

Stanek, K. Z.; Kochanek, C. S.; Shields, J. V.; Thompson, T. A.; Chomiuk, L.; Strader, J.; Shappee, B. J.; Holoien, T. W.-S.; Prieto, J. L.; Dong, Subo; Stritzinger, M.

2018-04-01

During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN, Shappee et al. 2014), using data from multiple ASAS-SN telescopes, we detect a new bright transient source, possibly a classical nova, but it might also be a young, large amplitude outburst of a cataclysmic variable Object RA (J2000) DEC (J2000) Gal l (deg) Gal b (deg) Disc.

Prompt Neutrinos from Atmospheric cc-bar and bb-bar Production and the Gluon at Very Small x

CERN Document Server

Martin, A D; Stasto, A M

2003-01-01

We improve the accuracy of the extrapolation of the gluon distribution of the proton to very small x, and show that the charm production cross section, needed to calculate the cosmic ray-induced 'atmospheric' flux of ultrahigh energy prompt nu submu and nu subtau neutrinos, may be predicted within perturbative QCD to within about a factor of three. We follow the sequence of interactions and decays in order to calculate the neutrino fluxes as a function of energy up to 10 sup 9 GeV. We also compute the prompt nu subtau flux from bb-bar production, hadronization and decay. New cosmic sources of neutrinos will be indicated if more prompt neutrinos are observed than predicted. If fewer neutrinos are observed than predicted, then constraints will be imposed on the nuclear composition of cosmic rays. The advantages of studying nu subtau neutrinos are emphasized. We provide a simple parametrization of the prediction for the inclusive cross section for c quark production in high energy proton-air collisions.

ENIGMATIC RECURRENT PULSATIONAL VARIABILITY OF THE ACCRETING WHITE DWARF EQ LYN (SDSS J074531.92+453829.6)

Energy Technology Data Exchange (ETDEWEB)

Mukadam, Anjum S.; Szkody, Paula [Department of Astronomy, University of Washington, Seattle, WA 98195-1580 (United States); Townsley, D. M.; Brockett, T. [Department of Physics and Astronomy, University of Alabama, Tuscaloosa, AL 35487 (United States); Gaensicke, B. T.; Parsons, S. [Department of Physics, University of Warwick, Coventry CV4 7AL (United Kingdom); Southworth, J. [Astrophysics Group, Keele University, Staffordshire ST5 5BG (United Kingdom); Hermes, J. J.; Montgomery, M. H.; Winget, D. E.; Harrold, S. [Department of Astronomy, University of Texas at Austin, Austin, TX 78759 (United States); Tovmassian, G.; Zharikov, S. [Observatorio Astronomico Nacional SPM, Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Ensenada, BC (Mexico); Drake, A. J. [Department of Astronomy and the Center for Advanced Computing Research, California Institute of Technology, Pasadena, CA 91225 (United States); Henden, A. [American Association of Variable Star Observers, 25 Birch Street, Cambridge, MA 02138 (United States); Rodriguez-Gil, P. [Departamento de Astrofisica, Universidad de La Laguna, La Laguna, E-38204 Santa Cruz de Tenerife (Spain); Sion, E. M. [Department of Astronomy and Astrophysics, Villanova University, Villanova, PA 19085 (United States); Zola, S.; Szymanski, T. [Astronomical Observatory, Jagiellonian University, ul. Orla 171, PL-30-244 Krakow (Poland); Pavlenko, E. [Crimean Astrophysical Observatory, Crimea 98409 (Ukraine); and others

2013-09-15

Photometric observations of the cataclysmic variable EQ Lyn (SDSS J074531.92+453829.6), acquired from 2005 October to 2006 January, revealed high-amplitude variability in the range 1166-1290 s. This accreting white dwarf underwent an outburst in 2006 October, during which its brightness increased by at least five magnitudes, and it started exhibiting superhumps in its light curve. Upon cooling to quiescence, the superhumps disappeared and it displayed the same periods in 2010 February as prior to the outburst within the uncertainties of a couple of seconds. This behavior suggests that the observed variability is likely due to nonradial pulsations in the white dwarf star, whose core structure has not been significantly affected by the outburst. The enigmatic observations begin with an absence of pulsational variability during a multi-site campaign conducted in 2011 January-February without any evidence of a new outburst; the light curve is instead dominated by superhumps with periods in the range of 83-87 minutes. Ultraviolet Hubble Space Telescope time-series spectroscopy acquired in 2011 March reveals an effective temperature of 15,400 K, placing EQ Lyn within the broad instability strip of 10,500-16,000 K for accreting pulsators. The ultraviolet light curve with 90% flux from the white dwarf shows no evidence of any pulsations. Optical photometry acquired during 2011 and Spring 2012 continues to reflect the presence of superhumps and an absence of pulsations. Subsequent observations acquired in 2012 December and 2013 January finally indicate the disappearance of superhumps and the return of pulsational variability with similar periods as previous data. However, our most recent data from 2013 March to May reveal superhumps yet again with no sign of pulsations. We speculate that this enigmatic post-outburst behavior of the frequent disappearance of pulsational variability in EQ Lyn is caused either by heating the white dwarf beyond the instability strip due to an

In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia.

Science.gov (United States)

Cheng, Zhi; Wei, Runhong; Ma, Qiuling; Shi, Lin; He, Feng; Shi, Zixiao; Jin, Tao; Xie, Ronglin; Wei, Baofeng; Chen, Jing; Fang, Hongliang; Han, Xiaolu; Rohrs, Jennifer A; Bryson, Paul; Liu, Yarong; Li, Qi-Jing; Zhu, Bo; Wang, Pin

2018-04-04

Several recent clinical trials have successfully incorporated a costimulatory domain derived from either CD28 or 4-1BB with the original CD3ζ T cell activating domain to form second-generation chimeric antigen receptors (CARs) that can increase the responsiveness and survival of CAR-engineered T (CAR-T) cells. However, a rigorous assessment of the individual benefits of these costimulatory components relative to the in vivo performance of infused T cells in patients is still lacking. Therefore, we have designed a study that allows us to investigate and compare the impact of different costimulatory signal domains on CAR-T cells in vivo. Patients with B cell leukemia were infused with a mixture of two types of CD19-specific CAR-T cells, individually bearing CD28 (28ζ) and 4-1BB (BBζ) costimulatory signaling domains. We found that such a clinical procedure was feasible and safe. Complete remission (CR) was observed in five of seven enrolled patients, with two patients exhibiting durable CR lasting more than 15 months. The in vivo expansion pattern of 28ζ and BBζ CAR-T cells varied significantly among individual patients. These results confirm a feasible method of comparing different CAR designs within individual patients, potentially offering objective insights that may facilitate the development of optimal CAR-T cell-based immunotherapies. Copyright © 2018 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

Present status of the interlaboratorial co-operative study for standards rocks of granite (GB-1) and basalt (BB-1) from the Geochemistry Department of I.G.U.F. Ba./Brazil

International Nuclear Information System (INIS)

Linhares, P.S.

1987-01-01

Results for major, minor and trace elements obtained by twelve laboratories for the standards rocks, Granite (GB-1) and Basalte (BB-1), of the Geochemistry Department of Geociences Institute-U-F.Ba are presented. At present status of the study it is possible to approach the most probably correct value (usable value) for the concentration of each of the major and minor elements. (author) [pt

Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial.

Science.gov (United States)

Bogovič Matijašić, Bojana; Obermajer, Tanja; Lipoglavšek, Luka; Sernel, Tjaša; Locatelli, Igor; Kos, Mitja; Šmid, Alenka; Rogelj, Irena

2016-07-01

We conducted a randomized double-blind, placebo-controlled multicentric study to investigate the influence of a synbiotic fermented milk on the fecal microbiota composition of 30 adults with irritable bowel syndrome (IBS). The synbiotic product contained Lactobacillus acidophilus La-5, Bifidobacterium animalis ssp. lactis BB-12, Streptococcus thermophilus, and dietary fiber (90% inulin, 10% oligofructose), and a heat-treated fermented milk without probiotic bacteria or dietary fiber served as placebo. Stool samples were collected after a run-in period, a 4-wk consumption period, and a 1-wk follow-up period, and were subjected to real-time PCR and 16S rDNA profiling by next-generation sequencing. After 4wk of synbiotic (11 subjects) or placebo (19 subjects) consumption, a greater increase in DNA specific for L. acidophilus La-5 and Bifidobacterium animalis ssp. lactis was detected in the feces of the synbiotic group compared with the placebo group by quantitative real-time PCR. After 1wk of follow-up, the content of L. acidophilus La-5 and B. animalis ssp. lactis decreased to levels close to initial levels. No significant changes with time or differences between the groups were observed for Lactobacillus, Enterobacteriaceae, Bifidobacterium, or all bacteria. The presence of viable BB-12- and La-5-like bacteria in the feces resulting from the intake of synbiotic product was confirmed by random amplification of polymorphic DNA (RAPD)-PCR. At the end of consumption period, the feces of all subjects assigned to the synbiotic group contained viable bacteria with a BB-12-like RAPD profile, and after 1wk of follow-up, BB-12-like bacteria remained in the feces of 87.5% of these subjects. The presence of La-5-like colonies was observed less frequently (37.5 and 25% of subjects, respectively). Next-generation sequencing of 16S rDNA amplicons revealed that only the percentage of sequences assigned to Strep. thermophilus was temporarily increased in both groups, whereas the

Search for the Standard Model Higgs boson produced in association with top quarks and decaying into bb in the ATLAS detector

CERN Document Server

Honda, Shunsuke; The ATLAS collaboration

2017-01-01

The Standard Model Higgs boson produced in association with a top-quark pair(ttbar) can permit direct measurement of the top Yukawa coupling. This poster is focused on the Higgs->bb channel with ttbar decaying into one or two electrons or muons. The analysis used pp collision data at the center of mass energy of 13 TeV, collected with the LHC-ATLAS detector in 2015-2016. The search is already limited by systematic uncertainties mostly in background modeling. In order to improve the sensitivity of the analysis, events are categorized according to their jet multiplicities and b-tagging properties. We present the latest result from the ATLAS experiment with improved techniques to discriminate signal from background dominated by ttbar+jets production.

Measurement of the ratio of branching fractions $B(B^0 \\to K^{\\ast 0} \\gamma) / B(B^0_s \\to \\phi \\gamma)$ and the direct $C\\!P$ asymmetry in $B^0 \\to K^{\\ast 0} \\gamma$

CERN Document Server

Aaij, R; Adametz, A; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amhis, Y; Anderlini, L; Anderson, J; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bates, A; Bauer, C; Bauer, Th; Bay, A; Beddow, J; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blanks, C; Blouw, J; Blusk, S; Bobrov, A; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Büchler-Germann, A; Burducea, I; Bursche, A; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Corti, G; Couturier, B; Cowan, G A; Craik, D; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Simone, P; Decamp, D; Deckenhoff, M; Degaudenzi, H; Del Buono, L; Deplano, C; Derkach, D; Deschamps, O; Dettori, F; Dickens, J; Dijkstra, H; Diniz Batista, P; Domingo Bonal, F; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisele, F; Eisenhardt, S; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Elsby, D; Esperante Pereira, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garnier, J-C; Garofoli, J; Garra Tico, J; Garrido, L; Gascon, D; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Harrison, P F; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Hill, D; Hoballah, M; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Huston, R S; Hutchcroft, D; Hynds, D; Iakovenko, V; Ilten, P; Imong, J; Jacobsson, R; Jaeger, A; Jahjah Hussein, M; Jans, E; Jansen, F; Jaton, P; Jean-Marie, B; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Keaveney, J; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kim, Y M; Knecht, M; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leroy, O; Lesiak, T; Li, L; Li, Y; Li Gioi, L; Lieng, M; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Luisier, J; Mac Raighne, A; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Magnin, J; Malde, S; Mamunur, R M D; Manca, G; Mancinelli, G; Mangiafave, N; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Massafferri, A; Mathe, Z; Matteuzzi, C; Matveev, M; Maurice, E; Mazurov, A; McCarthy, J; McGregor, G; McNulty, R; Meissner, M; Merk, M; Merkel, J; Milanes, D A; Minard, M-N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Mylroie-Smith, J; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen-Mau, C; Nicol, M; Niess, V; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pie Valls, B; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodriguez Perez, P; Rogers, G J; Roiser, S; Romanovsky, V; Romero Vidal, A; Rosello, M; Rouvinet, J; Ruf, T; Ruiz, H; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santinelli, R; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schleich, S; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Smith, M; Sobczak, K; Soler, F J P; Solomin, A; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tsaregorodtsev, A; Tuning, N; Ubeda Garcia, M; Ukleja, A; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Videau, I; Vieira, D; Vilasis-Cardona, X; Visniakov, J; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Witzeling, W; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhong, L; Zvyagin, A

2013-01-01

The ratio of branching fractions of the radiative $B$ decays $B^0\\rightarrow K^{*0}\\gamma$ and $B^0_s\\rightarrow\\phi\\gamma$ has been measured using an integrated luminosity of $1.0\\mbox{fb}^{-1}$ of $pp$ collision data collected by the LHCb experiment at a centre-of-mass energy of $\\sqrt{s}=7\\mathrm{\\,Te\\kern -0.1em V}$. The value obtained is \\begin{equation*} \\frac{{\\cal B}(B^0\\rightarrow K^{*0}\\gamma)}{{\\cal B} (B^0_s\\rightarrow\\phi\\gamma)} = 1.23 \\pm 0.06\\mathrm{\\,(stat.)} \\pm 0.04\\mathrm{\\,(syst.)} \\pm 0.10\\,(f_s/f_d)\\,, \\end{equation*} where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions $f_s/f_d$. Using the world average value for ${\\cal{B}}(B^0\\rightarrow K^{*0}\\gamma)$, the branching fraction ${\\cal{B}}(B^0_s\\rightarrow\\phi\\gamma)$ is measured to be $(3.5\\pm 0.4)\\times10^{-5}$. The direct CP asymmetry in $B^0\\rightarrow K^{*0}\\gamma$ decays has also been measured with the same data and f...

Soil variability in engineering applications

Science.gov (United States)

Vessia, Giovanna

2014-05-01

Finite Element Method (RFEM). This method has been used to investigate the random behavior of soils in the context of a variety of classical geotechnical problems. Afterward, some following studies collected the worldwide variability values of many technical parameters of soils (Phoon and Kulhawy 1999a) and their spatial correlation functions (Phoon and Kulhawy 1999b). In Italy, Cherubini et al. (2007) calculated the spatial variability structure of sandy and clayey soils from the standard cone penetration test readings. The large extent of the worldwide measured spatial variability of soils and rocks heavily affects the reliability of geotechnical designing as well as other uncertainties introduced by testing devices and engineering models. So far, several methods have been provided to deal with the preceding sources of uncertainties in engineering designing models (e.g. First Order Reliability Method, Second Order Reliability Method, Response Surface Method, High Dimensional Model Representation, etc.). Nowadays, the efforts in this field have been focusing on (1) measuring spatial variability of different rocks and soils and (2) developing numerical models that take into account the spatial variability as additional physical variable. References Cherubini C., Vessia G. and Pula W. 2007. Statistical soil characterization of Italian sites for reliability analyses. Proc. 2nd Int. Workshop. on Characterization and Engineering Properties of Natural Soils, 3-4: 2681-2706. Griffiths D.V. and Fenton G.A. 1993. Seepage beneath water retaining structures founded on spatially random soil, Géotechnique, 43(6): 577-587. Mandelbrot B.B. 1983. The Fractal Geometry of Nature. San Francisco: W H Freeman. Matheron G. 1962. Traité de Géostatistique appliquée. Tome 1, Editions Technip, Paris, 334 p. Phoon K.K. and Kulhawy F.H. 1999a. Characterization of geotechnical variability. Can Geotech J, 36(4): 612-624. Phoon K.K. and Kulhawy F.H. 1999b. Evaluation of geotechnical property

Estimation of snowfall limit for the Kashmir Valley, Indian Himalayas, with TRMM PR Bright Band information

Directory of Open Access Journals (Sweden)

S. Schauwecker

2016-09-01

Full Text Available Knowing the height of the snowfall limit during precipitation events is crucial for better understanding a number of hydro-climatic processes, for instance glacier-climate interactions or runoff from high mountain catchments. However, knowledge on heights of the phase change during precipitation events is limited by the small number of meteorological measurements available at high altitudes, such as the Himalayas. The bright band (BB of satellite based radar data may be a promising proxy for the snow/rain transition during particular stratiform precipitation events over high mountain regions. The BB is a horizontal layer of stronger radar reflectivity caused by the melting of hydrometeors at the level where solid precipitation turns into rain. Here, we present BB heights detected by the Tropical Rainfall Measuring Mission (TRMM Precipitation Radar (PR 2A23 algorithm over a mountainous area. To assess the performance of BB heights, we have compared a 17‑year data set of BB estimations of the TRMM PR with radiosonde observations and meteorological station data from Srinagar, Kashmir Valley, India. During March to November, the BB lies mostly about 200 to 800 m below the freezing level (FL recorded by radiosondes. The correlation between BB and FL heights extrapolated from a ground-based station is smaller and depends on the timing of the air temperature measurement – an important finding for applying extrapolation techniques in data sparse regions. Further on, we found a strong seasonal and monthly variability of the BB height, e.g. extending in summer months from about 2700 m to almost 6000 m asl. Comparison with near surface rain intensity from the TRMM PR product 2A25 indicates that – during intense monsoonal summer precipitation events – the BB height is concentrated between about 3500 and 4000 m asl. We can conclude that TRMM PR BB data deliver valuable complementary information for regional or seasonal variability

New Method To Estimate Total Polyphenol Excretion: Comparison of Fast Blue BB versus Folin-Ciocalteu Performance in Urine.

Science.gov (United States)

Hinojosa-Nogueira, Daniel; Muros, Joaquín; Rufián-Henares, José A; Pastoriza, Silvia

2017-05-24

Polyphenols are bioactive substances of vegetal origin with a significant impact on human health. The assessment of polyphenol intake and excretion is therefore important. The Folin-Ciocalteu (F-C) method is the reference assay to measure polyphenols in foods as well as their excretion in urine. However, many substances can influence the method, making it necessary to conduct a prior cleanup using solid-phase extraction (SPE) cartridges. In this paper, we demonstrate the use of the Fast Blue BB reagent (FBBB) as a new tool to measure the excretion of polyphenols in urine. Contrary to F-C, FBBB showed no interference in urine, negating the time-consuming and costly SPE cleanup. In addition, it showed excellent linearity (r 2 = 0.9997), with a recovery of 96.4% and a precision of 1.86-2.11%. The FBBB method was validated to measure the excretion of polyphenols in spot urine samples from Spanish children, showing a good correlation between polyphenol intake and excretion.

Discovery of an old nova shell surrounding the cataclysmic variable V1315 Aql

Science.gov (United States)

Sahman, D. I.; Dhillon, V. S.; Littlefair, S. P.; Hallinan, G.

2018-04-01

Following our tentative discovery of a faint shell around V1315 Aql reported in Sahman et al. (2015), we undertook deep Hα imaging and intermediate-resolution spectroscopy of the shell. We find that the shell has its geometric centre located on V1315 Aql. The mass, spectral features and density of the shell are consistent with other nova shells, rather than planetary nebulae or supernova remnants. The radial velocity of the shell is consistent with the systemic velocity of V1315 Aql. We believe this evidence strongly suggests that the shell originates from an earlier nova event. This is the first nova shell discovered around a novalike, and supports the theory of nova-induced cycles in mass transfer rates (hibernation theory) first proposed by Shara et al. (1986).

PI3K is involved in PDGF-beta receptor upregulation post-PDGF-BB treatment in mouse HSC.

Science.gov (United States)

Lechuga, Carmen G; Hernández-Nazara, Zamira H; Hernández, Elizabeth; Bustamante, Marcia; Desierto, Gregory; Cotty, Adam; Dharker, Nachiket; Choe, Moran; Rojkind, Marcos

2006-12-01

Increased expression of PDGF-beta receptors is a landmark of hepatic stellate cell activation and transdifferentiation into myofibroblasts. However, the molecular mechanisms that regulate the fate of the receptor are lacking. Recent studies suggested that N-acetylcysteine enhances the extracellular degradation of PDGF-beta receptor by cathepsin B, thus suggesting that the absence of PDGF-beta receptors in quiescent cells is due to an active process of elimination and not to a lack of expression. In this communication we investigated further molecular mechanisms involved in PDGF-beta receptor elimination and reappearance after incubation with PDGF-BB. We showed that in culture-activated hepatic stellate cells there is no internal protein pool of receptor, that the protein is maximally phosphorylated by 5 min and completely degraded after 1 h by a lysosomal-dependent mechanism. Inhibition of receptor autophosphorylation by tyrphostin 1296 prevented its degradation, but several proteasomal inhibitors had no effect. We also showed that receptor reappearance is time and dose dependent, being more delayed in cells treated with 50 ng/ml (48 h) compared with 10 ng/ml (24 h).

Tracking variable sedimentation rates in orbitally forced paleoclimate proxy series

Science.gov (United States)

Li, M.; Kump, L. R.; Hinnov, L.

2017-12-01

This study addresses two fundamental issues in cyclostratigraphy: quantitative testing of orbital forcing in cyclic sedimentary sequences and tracking variable sedimentation rates. The methodology proposed here addresses these issues as an inverse problem, and estimates the product-moment correlation coefficient between the frequency spectra of orbital solutions and paleoclimate proxy series over a range of "test" sedimentation rates. It is inspired by the ASM method (1). The number of orbital parameters involved in the estimation is also considered. The method relies on the hypothesis that orbital forcing had a significant impact on the paleoclimate proxy variations, and thus is also tested. The null hypothesis of no astronomical forcing is evaluated using the Beta distribution, for which the shape parameters are estimated using a Monte Carlo simulation approach. We introduce a metric to estimate the most likely sedimentation rate using the product-moment correlation coefficient, H0 significance level, and the number of contributing orbital parameters, i.e., the CHO value. The CHO metric is applied with a sliding window to track variable sedimentation rates along the paleoclimate proxy series. Two forward models with uniform and variable sedimentation rates are evaluated to demonstrate the robustness of the method. The CHO method is applied to the classical Late Triassic Newark depth rank series; the estimated sedimentation rates match closely with previously published sedimentation rates and provide a more highly time-resolved estimate (2,3). References: (1) Meyers, S.R., Sageman, B.B., Amer. J. Sci., 307, 773-792, 2007; (2) Kent, D.V., Olsen, P.E., Muttoni, G., Earth-Sci. Rev.166, 153-180, 2017; (3) Li, M., Zhang, Y., Huang, C., Ogg, J., Hinnov, L., Wang, Y., Zou, Z., Li, L., 2017. Earth Plant. Sc. Lett. doi:10.1016/j.epsl.2017.07.015

The type Ia supernova SNLS-03D3bb from a super-Chandrasekhar-masswhite dwarf star

Energy Technology Data Exchange (ETDEWEB)

Howell, D.Andrew; Sullivan, Mark; Nugent, Peter E.; Ellis,Richard S.; Conley, Alexander J.; Le Borgne, Damien; Carlberg, RaymondG.; Guy, Julien; Balam, David; Basa, Stephane; Fouchez, Dominique; Hook,Isobel M.; Hsiao, Eric Y.; Neill, James D.; Pain, Reynald; Perrett,Kathryn M.; Pritchet, Christopher J.

2006-02-01

The acceleration of the expansion of the universe, and theneed for Dark Energy, were inferred from the observations of Type Iasupernovae (SNe Ia) 1;2. There is consensus that SNeIa are thermonuclearexplosions that destroy carbon-oxygen white dwarf stars that accretematter from a companion star3, although the nature of this companionremains uncertain. SNe Ia are thought to be reliable distance indicatorsbecause they have a standard amount of fuel and a uniform trigger theyare predicted to explode when the mass of the white dwarf nears theChandrasekhar mass 4 - 1.4 solar masses. Here we show that the highredshift supernova SNLS-03D3bb has an exceptionally high luminosity andlow kinetic energy that both imply a super-Chandrasekhar mass progenitor.Super-Chandrasekhar mass SNeIa shouldpreferentially occur in a youngstellar population, so this may provide an explanation for the observedtrend that overluminous SNe Ia only occur in young environments5;6. Sincethis supernova does not obey the relations that allow them to becalibrated as standard candles, and since no counterparts have been foundat low redshift, future cosmology studies will have to considercontamination from such events.

Measurements of partial widths and forward-backward asymmetries in Z sup 0 decays into ss-bar, cc-bar and bb-bar-preliminary results

CERN Document Server

Axelsson, M G

1999-01-01

Measurements are reported of partial widths and forward-backward asymmetries in flavour-identified quark final states based on the full LEP1 statistics, corresponding to 3x10 sup 6 hadronic Z sup 0 decays collected by the DELPHI experiment from 1992 to 1995. Particle identification provided by the Ring Imaging Cherenkov counters and the Time Projection Chamber is used to obtain clear D sup 0 , D sup + , D sub s sup + and LAMBDA sub c sup + signatures. A measurement of the charm multiplicity in bb-bar events is also presented. Identification of high-energy charged kaons is used to tag the s quark. Two methods for determination of the forward-backward asymmetry of the s quark are presented.

Superoutburst of 0203+56A UV Persei

Science.gov (United States)

Waagen, Elizabeth O.

1991-12-01

Cataclysmic variable 0203+56A UV Per is currently undergoing a superoutburst reaching ~11.5 magnitude. SU UMa is also in superoutburst reaching ~11.7 magnitude. Reiki Kushida made a visual discovery of a supernova in NGC 4374 on December 9.844 UT. 1950 Epoch position is set at 12h 22' 31.54", +13° 08' 52.4". Observations of the supernova its magnitude at ~14.7.

Photometry and Low Dispersion Spectroscopy with ESA Gaia

Czech Academy of Sciences Publication Activity Database

Hudec, R.; Šimon, Vojtěch; Hudec, L.

2010-01-01

Roč. 2010, - (2010), 781421/1-781421/7 ISSN 1687-7969 R&D Projects: GA ČR GA205/08/1207 Grant - others:GA AV ČR(CZ) GA102/09/0997; GA MŠk(CZ) ME09027; ESA(XE) ESA- PECS project No. Institutional research plan: CEZ:AV0Z10030501 Keywords : high-energy sources * cataclysmic variables * low-dispersion spectra Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

CP violation in single top quark production and decay via pp-bar --> tb-bar + X --> W sup + bb-bar + X within the MSSM A possible application for measuring arg(At) at hadron colliders

CERN Document Server

Bar-Shalom, S; Soni, A

1998-01-01

CP-nonconserving effects in the reaction pp-bar-->tb-bar+X--> W sup + bb-bar+X, driven by the supersymmetric CP-odd phase of the top squark trilinear soft breaking term arg(A sub t), are studied. We discuss the CP-nonconserving effects in both production and the associated decay amplitudes of the top quark. We find that, within a plausible low energy scenario of the MSSM and keeping the neutron electric dipole moment below its current limit, a CP-violating cross-section asymmetry as large as 2-3% can arise if some of the parameters lie in a favorable range. A partial rate asymmetry originating only in the top quark decay t --> W sup + b is found to be, in general, below the 0.1% level which is somewhat smaller than previous claims. For a low tan beta of order one the decay asymmetry can reach at the most approx 0.3%. This (few) percent level overall CP-violating signal in pp-bar --> tb-bar + X --> W sup + bb-bar + X might be within the reach of the future 2(4) TeV pp-bar Fermilab Tevatron collider that may be...

Spectral analysis in overmodulated holographic reflection gratings recorded with BB640 ultrafine grain emulsion

Science.gov (United States)

Mas-Abellán, P.; Madrigal, R.; Fimia, A.

2015-05-01

Silver halide emulsions have been considered one of the most energetic sensitive materials for holographic applications. Nonlinear recording effects on holographic reflection gratings recorded on silver halide emulsions have been studied by different authors obtaining excellent experimental results. In this communication specifically we focused our investigation on the effects of refractive index modulation, trying to get high levels of overmodulation. We studied the influence of the grating thickness on the overmodulation and its effects on the transmission spectra for a wide exposure range by use of two different thickness ultrafine grain emulsion BB640, thin films (6 μm) and thick films (9 μm), exposed to single collimated beams using a red He-Ne laser (wavelength 632.8 nm) with Denisyuk configuration obtaining a spatial frequency of 4990 l/mm recorded on the emulsion. The experimental results show that high overmodulation levels of refractive index could offer some benefits such as high diffraction efficiency (reaching 90 %), increase of grating bandwidth (close to 80 nm), making lighter holograms, or diffraction spectra deformation, transforming the spectrum from sinusoidal to approximation of square shape. Based on these results, we demonstrate that holographic reflection gratings spectra recorded with overmodulation of refractive index is formed by the combination of several non-linear components due to very high overmodulation. This study is the first step to develop a new easy multiplexing technique based on the use of high index modulation reflection gratings.

Rare earths determination methods, with separation pre-irradiation followed by neutron activation. Utilization of brazilian standards BB-I and GB-I

International Nuclear Information System (INIS)

Alcala, A.L.; Figueiredo, A.M.G.; Marques, L.S.; Astolfo, R.

1989-01-01

In order to determine the rare earth elements (REE) in rocks, by neutron activation analysis, a group separation, before irradiation, was developed. The Brazilian geological standards BB-1 and GB-1, from Instituto de Geociencias da Universidade da Bahia, were analyzed. The method was based on acid digestion of the samples, cation exchange separation with a Dowex 50WX8 column and coprecipitation of the REE with calcium oxalate. Interferents like U, Th, Ta and Fe were eliminated. The concentration values of ten REE (La, Ce, Pr, Nd, Sm, Eu, Tb, Ho, Yb, and Lu) were determined. The analysis of Pr brought a contribution to the knowledge of the REE contents in these geological standards, since there are not yet results in the literature. The other REE data obtained were compared with literature values and some discrepancies are discussed. (author) [pt

Gluon fusion and bb¯ corrections to HW+W−/HZZ production in the POWHEG-BOX

Directory of Open Access Journals (Sweden)

Julien Baglio

2017-01-01

Full Text Available The study of the Higgs boson properties is one of the most important tasks to be accomplished in the next years, at the Large Hadron Collider (LHC and at future colliders such as the Future Circular Collider in hadron–hadron mode (FCC-hh, the potential 100 TeV follow-up of the LHC machine. In this view the precise study of the Higgs couplings to weak gauge bosons is crucial and requires as much information as possible. After the recent calculation of the next-to-leading order QCD corrections to the production cross sections and differential distributions of a Standard Model Higgs boson in association with a pair of weak bosons, matched with parton shower in the POWHEG-BOX framework, we present the gluon fusion correction gg→HW+W−(HZZ to the process pp→HW+W−(HZZ. This correction can be sizeable and amounts to +3% (+10% in the HW+W− process and +5% (+18% in the HZZ process at the LHC (FCC-hh. We also present the first study of the impact of the bottom-quark initiated channels bb¯→HW+W−/HZZ and find that they induce a significant +18% correction in the HW+W− channel at the FCC-hh. We present results on total cross sections and distributions at the LHC and at the FCC-hh.

Fractional analytic perturbation theory in Minkowski space and application to Higgs boson decay into a bb pair

International Nuclear Information System (INIS)

Bakulev, A. P.; Mikhailov, S. V.; Stefanis, N. G.

2007-01-01

We work out and discuss the Minkowski version of fractional analytic perturbation theory for QCD observables, recently developed and presented by us for the Euclidean region. The original analytic approach to QCD, initiated by Shirkovand Solovtsov, is summarized and relations to other proposals to achieve an analytic strong coupling are pointed out. The developed framework is applied to the Higgs boson decay into a bb pair, using recent results for the massless correlator of two quark scalar currents in the MS scheme.We present calculations for the decay width within the Minkowski version off ractional analytic perturbation theory including those non-power-series contributions that correspond to the O(α s 3 )-terms, also taking into account evolution effects of the running coupling and the b-quark-mass renormalization. Comparisons with previous results within standard QCD perturbation theory are performed and the differences are pointed out. The interplay between effects originating from the analyticity requirement and the analytic continuation from the spacelike to the timelike region and those due to the evolution of the heavy-quark mass is addressed, highlighting the differences from the conventional QCD perturbation theory

Role of mixed precipitating cloud systems on the typhoon rainfall

Directory of Open Access Journals (Sweden)

C. J. Pan

2010-01-01

Full Text Available L-band wind profiler data are utilized to diagnose the vertical structure of the typhoon precipitating cloud systems in Taiwan. For several typhoons, a pronounced bright band (BB around 5 km is commonly observed from the observation. Since strong convection within typhoon circulation may disturb and/or disrupt the melting layer, the BB shall not appear persistently. Hence, an understanding of the vertical structure of the BB region is important because it holds extensive hydrometeors information on the type of precipitation and its variability. Wind profiler observational results suggest that the mixture of convective and stratiform (embedded type clouds are mostly associated with typhoons. In the case of one typhoon, BB is appeared around 5.5 km with embedded precipitation and also BB height of 1 km higher than ordinary showery precipitation. This is evident from the long-term observations of wind profiler and Tropical Rainfall Measuring Mission. The Doppler velocity profiles show hydrometers (ice/snow at 6 km but liquid below 5 km for typhoons and 4 km for showery precipitation. In the BB region the melting particles accelerations of 5.8 ms−1 km−1 and 3.2 ms−1 km−1 are observed for typhoon and showery precipitation, respectively.

Search for the standard model Higgs boson in the ZH→νν¯bb¯ channel in 9.5 fb−1 of pp¯ collisions at √(s)=1.96 TeV

International Nuclear Information System (INIS)

Abazov, V.M.; Abbott, B.; Acharya, B.S.; Adams, M.; Adams, T.; Alexeev, G.D.; Alkhazov, G.; Alton, A.; Alverson, G.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D.V.; Banerjee, S.; Barberis, E.; Baringer, P.

2012-01-01

We present a search for the standard model Higgs boson in 9.5 fb -1 of pp ¯ collisions at √(s)=1.96 TeV collected with the D0 detector at the Fermilab Tevatron Collider. The final state considered contains a pair of b jets and is characterized by an imbalance in transverse energy, as expected from pp ¯ →ZH→νν ¯ bb ¯ production. The search is also sensitive to the WH→ℓνbb ¯ channel when the charged lepton is not identified. The data are found to be in good agreement with the expected background. For a Higgs boson mass of 125 GeV, we set a limit at the 95% C.L. on the cross section σ(pp ¯ →[Z/W]H), assuming standard model branching fractions, that is a factor of 4.3 times larger than the theoretical standard model value, while the expected factor is 3.9. The search is also used to measure a combined WZ and ZZ production cross section that is a factor of 0.94±0.31(stat)±0.34(syst) times the standard model prediction of 4.4 pb, with an observed significance of 2.0 standard deviations.

Effects of Indole-Butyric Acid Doses, Different Rooting Media and Cutting Thicknesses on Rooting Ratios and Root Qualities of 41B, 5 BB and 420A American Grapevine Rootstocks

OpenAIRE

DOĞAN, Adnan; UYAK, Cüneyt; KAZANKAYA, Ahmet

2016-01-01

The present study was conducted to investigate the effects of different rooting media [perlite, perlite+sand (1:1), perlite+sand+soil (1:1:1)], different indole butyric acid (IBA) doses (control, 1000, 2000, 3000 and 4000 ppm) and different cutting thicknesses [thin (4-7 mm), medium (8-10 mm) and thick (10-12 mm)] on rooting and root qualities of 41B, 5BB and 420A American grapevine rootstocks adapted to Van region of Turkey. Within the scope of the study, rooting ratios (%), number of roots,...

Request for Observations of V405 Peg

Science.gov (United States)

Templeton, Matthew R.

2009-12-01

Dr. Axel Schwope (Astrophysikalisches Institut Potsdam) requests time-series monitoring of the magnetic cataclysmic variable V405 Pegasi from 2009 December 28 through 2009 December 30. These observations are requested in support of a planned XMM-Newton observation of V405 Peg on 2009 December 29 beginning at 18:51 UT (JD 2455195.2854) and continuing for 12.5 hours. Observers are asked to provide intensive coverage during the three day window centered on the XMM-Newton observation to provide information on the activity state of V405 Peg, to improve the orbital ephemeris, and to provide optical data that will help constrain the spectral energy distribution of this poorly understood cataclysmic variable. The primary filters for this observation are Johnson B and Cousins I, but all observations will be useful for determining the orbital ephemeris. V405 Peg may show both orbital modulation as well as changes in its activity level. The orbital period is approximately four hours, and observers are asked to obtain at least ten and preferably more data points per cycle in each filter. Please use exposure times that provide S/N of at least 20 in both the comparison and target stars but short exposure times are preferred to detect flickering and other short-timescale variations. Finder charts with sequence may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details.

Search for heavy resonances decaying to a W or Z boson and a Higgs boson in the qq¯(′bb¯ final state in pp collisions at s=13 TeV with the ATLAS detector

Directory of Open Access Journals (Sweden)

M. Aaboud

2017-11-01

Full Text Available A search for heavy resonances decaying to a W or Z boson and a Higgs boson in the qq¯(′bb¯ final state is described. The search uses 36.1 fb−1 of proton–proton collision data at s=13 TeV collected by the ATLAS detector at the CERN Large Hadron Collider in 2015 and 2016. The data are in agreement with the Standard Model expectations, with the largest excess found at a resonance mass of 3.0 TeV with a local (global significance of 3.3 (2.1 σ. The results are presented in terms of constraints on a simplified model with a heavy vector triplet. Upper limits are set on the production cross-section times branching ratio for resonances decaying to a W (Z boson and a Higgs boson, itself decaying to bb¯, in the mass range between 1.1 and 3.8 TeV at 95% confidence level; the limits range between 83 and 1.6 fb (77 and 1.1 fb at 95% confidence level.

Search for the standard model Higgs boson decaying to a bb pair in events with two oppositely charged leptons using the full CDF data set.

Science.gov (United States)

Aaltonen, T; Álvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Bae, T; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M E; Bisello, D; Bizjak, I; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brigliadori, L; Bromberg, C; Brucken, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Calamba, A; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chung, W H; Chung, Y S; Ciocci, M A; Clark, A; Clarke, C; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuevas, J; Culbertson, R; Dagenhart, D; d'Ascenzo, N; Datta, M; de Barbaro, P; Dell'Orso, M; Demortier, L; Deninno, M; Devoto, F; d'Errico, M; Di Canto, A; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, M; Dorigo, T; Ebina, K; Elagin, A; Eppig, A; Erbacher, R; Errede, S; Ershaidat, N; Eusebi, R; Farrington, S; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Funakoshi, Y; Furic, I; Gallinaro, M; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldin, D; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Grinstein, S; Grosso-Pilcher, C; Group, R C; Guimaraes da Costa, J; Hahn, S R; Halkiadakis, E; Hamaguchi, A; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Hewamanage, S; Hocker, A; Hopkins, W; Horn, D; Hou, S; Hughes, R E; Hurwitz, M; Husemann, U; Hussain, N; Hussein, M; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeans, D T; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kim, Y J; Kimura, N; Kirby, M; Klimenko, S; Knoepfel, K; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Kruse, M; Krutelyov, V; Kuhr, T; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; LeCompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leo, S; Leone, S; Lewis, J D; Limosani, A; Lin, C-J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, H; Liu, Q; Liu, T; Lockwitz, S; Loginov, A; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Madrak, R; Maeshima, K; Maestro, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Martínez, M; Mastrandrea, P; Matera, K; Mattson, M E; Mazzacane, A; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Noh, S Y; Norniella, O; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Poprocki, S; Potamianos, K; Prokoshin, F; Pranko, A; Ptohos, F; Punzi, G; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Rescigno, M; Riddick, T; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Safonov, A; Sakumoto, W K; Sakurai, Y; Santi, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shochet, M; Shreyber-Tecker, I; Simonenko, A; Sinervo, P; Sliwa, K; Smith, J R; Snider, F D; Soha, A; Sorin, V; Song, H; Squillacioti, P; Stancari, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Tipton, P; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Ukegawa, F; Uozumi, S; Varganov, A; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vizán, J; Vogel, M; Volpi, G; Wagner, P; Wagner, R L; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Wester, W C; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Wick, F; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamato, D; Yang, T; Yang, U K; Yang, Y C; Yao, W-M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhou, C; Zucchelli, S

2012-09-14

We present a search for the standard model Higgs boson produced in association with a Z boson in data collected with the CDF II detector at the Tevatron, corresponding to an integrated luminosity of 9.45  fb(-1). In events consistent with the decay of the Higgs boson to a bottom-quark pair and the Z boson to electron or muon pairs, we set 95% credibility level upper limits on the ZH production cross section times the H→bb branching ratio as a function of Higgs boson mass. At a Higgs boson mass of 125  GeV/c(2), we observe (expect) a limit of 7.1 (3.9) times the standard model value.

Pulsating White Dwarfs in Cataclysmic Variables: The Marriage of ZZ Cet and Dwarf Nova

OpenAIRE

Warner, Brian; Woudt, Patrick A.

2003-01-01

There are now four dwarf novae known with white dwarf primaries that show large amplitude non-radial oscillations of the kind seen in ZZ Cet stars. We compare the properties of these stars and point out that by the end of the Sloan Digital Sky Survey more than 30 should be known.

MASTER OT J072007.30+451611.6: Cataclysmic Variable with an Extreme Hot Spot

Science.gov (United States)

Denisenko, D.

2018-05-01

MASTER team has reported an unusual object MASTER OT J072007.30+451611.6 in ATel #11620 (T. Pogrosheva et al.). The object was observed at 17.0-17.2m during 9 minutes from 22:15:26 to 22:24:30 UT on 2018-04-26, but was below the detection limit (18.8m) 45 minutes before the first positive observation and 43 minutes after the last one. As noted by S. Otero in AAVSO VSX entry, MASTER OT J072007.30+451611.6 has an X-ray counterpart XMMSL2 J072007.4+451615.

Analysis of the Latitudinal Variability of Tropospheric Ozone in the Arctic Using the Large Number of Aircraft and Ozonesonde Observations in Early Summer 2008

Science.gov (United States)

Ancellet, Gerard; Daskalakis, Nikos; Raut, Jean Christophe; Quennehen, Boris; Ravetta, Francois; Hair, Jonathan; Tarasick, David; Schlager, Hans; Weinheimer, Andrew J.; Thompson, Anne M.;

Methods for Clustering Variables and the Use of them in Statistical Packages

Czech Academy of Sciences Publication Activity Database

Řezanková, H.; Húsek, Dušan

2002-01-01

Roč. 10, - (2002), s. 153-160 ISSN 1210-809X. [Applications of Mathematics and Statistics in Economy. Zadov, 13.09.2001-14.09.2001] R&D Projects: GA ČR GA201/01/1192 Institutional research plan: AV0Z1030915 Keywords : factor analysis * cluster analysis * multidimensional * statistical packages Subject RIV: BB - Applied Statistics, Operational Research

New Insights from Inside-Out Doppler Tomography

Directory of Open Access Journals (Sweden)

E. J. Kotze

2015-02-01

Full Text Available We present preliminary results from our investigation into using an “inside-out” velocity space for creating a Doppler tomogram. The aim is to transpose the inverted appearance of the Cartesian velocity space used in normal Doppler tomography. In a comparison between normal and inside-out Doppler tomograms of cataclysmic variables, we show that the inside-out velocity space has the potential to produce new insights into the accretion dynamics in these systems.

Intermediate polars observed from Brazil in the last eight years

International Nuclear Information System (INIS)

Jablonski, F.

1988-01-01

The results of observations done, in the last eight years, of the Intermidiate Polars (IP): EX Hya, V1223 Sgr, FO Agr and Ao Psc, are presented. The IP define a subclass of cataclysmic variable stars that present coherent oscillations in their optical and/or X-ray emission. The observations were done from Laboratorio Nacional de Astrofisica, in Itajuba (Brazil). The stability of oscillations in IP was analysed to study the nature of compact stars. (M.C.K.) [pt

Infrared photometry of cataclysmic variables. II - Evidence for ellipsoidal variations in CW MoN, X Leo, IP Peg, and AF CaM

Science.gov (United States)

Szkody, P.; Mateo, M.

1986-08-01

Broadband H or K light curves of the dwarf novae CM Mon, X Leo, IP Peg, and AF Cam reveal variations that can be attributed to ellipsoidal modulation of the secondaries in these systems. The present data imply orbital periods of 4.23 + or - 0.01 hr for CW Mon and 5.0 + or - 0.1 hr for X Leo. The high-amplitude ellipsoidal modulation of the secondary of CW Mon implies a large orbital inclination. The interpretation of the low-amplitude variability seen in X Leo is complicated by details in its light curve and a recent determination of its orbital period by Shafter and Harkness (1986) which differs significantly from the period inferred from the present observations. The light variations of the eclipsing system IP Peg are interpreted as showing a 0.2 mag ellipsoidal variation from the secondary superposed on a deep eclipse of the IR light of the white dwarf and hotspot. AF Cam shows marginal evidence for a low-amplitude variation implying a very short orbital period of 76 min. IR colors of SS Aur, AH Eri, and IR Gem as well as the above four objects are used to place limits on the properties of the secondaries and the distances to these systems.

Role of mixed precipitating cloud systems on the typhoon rainfall

Directory of Open Access Journals (Sweden)

C. J. Pan

2010-01-01

Full Text Available L-band wind profiler data are utilized to diagnose the vertical structure of the typhoon precipitating cloud systems in Taiwan. For several typhoons, a pronounced bright band (BB around 5 km is commonly observed from the observation. Since strong convection within typhoon circulation may disturb and/or disrupt the melting layer, the BB shall not appear persistently. Hence, an understanding of the vertical structure of the BB region is important because it holds extensive hydrometeors information on the type of precipitation and its variability. Wind profiler observational results suggest that the mixture of convective and stratiform (embedded type clouds are mostly associated with typhoons. In the case of one typhoon, BB is appeared around 5.5 km with embedded precipitation and also BB height of 1 km higher than ordinary showery precipitation. This is evident from the long-term observations of wind profiler and Tropical Rainfall Measuring Mission. The Doppler velocity profiles show hydrometers (ice/snow at 6 km but liquid below 5 km for typhoons and 4 km for showery precipitation. In the BB region the melting particles accelerations of 5.8 ms⁻¹ km⁻¹ and 3.2 ms⁻¹ km⁻¹ are observed for typhoon and showery precipitation, respectively.

The type Ia supernova SNLS-03D3bb from a super-Chandrasekhar-mass white dwarf star.

Science.gov (United States)

Howell, D Andrew; Sullivan, Mark; Nugent, Peter E; Ellis, Richard S; Conley, Alexander J; Le Borgne, Damien; Carlberg, Raymond G; Guy, Julien; Balam, David; Basa, Stephane; Fouchez, Dominique; Hook, Isobel M; Hsiao, Eric Y; Neill, James D; Pain, Reynald; Perrett, Kathryn M; Pritchet, Christopher J

2006-09-21

The accelerating expansion of the Universe, and the need for dark energy, were inferred from observations of type Ia supernovae. There is a consensus that type Ia supernovae are thermonuclear explosions that destroy carbon-oxygen white dwarf stars that have accreted matter from a companion star, although the nature of this companion remains uncertain. These supernovae are thought to be reliable distance indicators because they have a standard amount of fuel and a uniform trigger: they are predicted to explode when the mass of the white dwarf nears the Chandrasekhar mass of 1.4 solar masses (M(o)). Here we show that the high-redshift supernova SNLS-03D3bb has an exceptionally high luminosity and low kinetic energy that both imply a super-Chandrasekhar-mass progenitor. Super-Chandrasekhar-mass supernovae should occur preferentially in a young stellar population, so this may provide an explanation for the observed trend that overluminous type Ia supernovae occur only in 'young' environments. As this supernova does not obey the relations that allow type Ia supernovae to be calibrated as standard candles, and as no counterparts have been found at low redshift, future cosmology studies will have to consider possible contamination from such events.

Photometry and Multipolar Magnetic Field Modeling of Polars: BY Camelopardalis and FL Ceti

Directory of Open Access Journals (Sweden)

P. A. Mason

2015-02-01

Full Text Available We present new broad band optical photometry of two magnetic cataclysmic variable stars, the asynchronous polar BY Camelopardalis and the short period polar FL Ceti. Observations were obtained at the 2.1-m Otto Struve Telescope of McDonald Observatory with 3s and 1s integration times respectively. In an attempt to understand the observed complex changes in accretion flow geometry observed in BY Cam, we performed full 3D MHD simulations assuming a variety of white dwarf magnetic field structures. We investigate fields with increasing complexity including both aligned and non-aligned dipole plus quadrupole field components. We compare model predictions with photometry at various phases of the beat cycle and find that synthetic light curves derived from a multipolar field structure are broadly consistent with optical photometry. FL Ceti is observed to have two very small accretion regions at the foot-points of the white dwarf’s magnetic field. Both accretion regions are visible at the same time in the high state and are about 100 degrees apart. MHD modeling using a dipole plus quadrupole field structure yields quite similar accretion regions as those observed in FL Ceti. We conclude that accretion flows calculated from MHD modeling of multi-polar magnetic fields produce synthetic light curves consistent with photometry of these magnetic cataclysmic variables.

Determination of rare earth elements with group separation irradiation followed by neutron activation analysis. Application to brazilian standards BB-1 and GB-1

International Nuclear Information System (INIS)

Alcala, A.L.; Figueiredo, A.M.G.; Marques, L.S.; Astolfo, R.

1989-01-01

In order to determine the rare earth elements (REE) in rocks, by neutron activation analysis, a group separation, before irradiation, was developed. The Brazilian geological standards BB-1 and GB-1, provided by Instituto de Geociencias da Universidade da Bahia, were analyzed. The method was based on acid digestion of the samples, cation exchange separation with a Dowex 50WX8 column and coprecipitation of the REE with calcium oxalate. Interferents, like U, Th, Ta and Fe were eliminated. The concentration values of ten REE's (La, Ce, Pr, Nd, Sm, Eu, Tb, Ho, Yb and Lu) were determined. The analysis of Pr made a contribution to the knowledge of the REE contents in these geological standards, since there are not yet results in the literature. The other REE data obtained were compared with literature values and some discrepancies are discussed. (author) [pt

On the nature of WX Ceti

International Nuclear Information System (INIS)

Downes, R.A.; Margon, B.

1981-01-01

WX Ceti is a large amplitude (8 mag) variable which has undergone at least four outbursts during this century. Bailey has suggested that this object may be related to WZ Sge, and is part of a small but distinct subgroup of dwarf novae. Spectroscopy of WX Cet has been obtained at minimum light, revealing extremely strong, broad Balmer emission, but no He II lambda 4686. The spectrum indeed resembles WZ Sge at minimum, although it lacks the broad Balmer absorptions of the latter object. The data confirm the cataclysmic variable nature of WX Cet, and indicate that the proposed association with WZ Sge is plausible. (author)

Biochemical and kinetic characterisation of a novel xylooligosaccharide-upregulated GH43 β-d-xylosidase/α-l-arabinofuranosidase (BXA43) from the probiotic Bifidobacterium animalis subsp. lactis BB-12

DEFF Research Database (Denmark)

Viborg, Alexander Holm; Sørensen, Kim Ib; Gilad, Ofir

2013-01-01

The Bifidobacterium animalis subsp. lactis BB-12 gene BIF_00092, assigned to encode a β-d-xylosidase (BXA43) of glycoside hydrolase family 43 (GH43), was cloned with a C-terminal His-tag and expressed in Escherichia coli. BXA43 was purified to homogeneity from the cell lysate and found to be a dual......-specificity exo-hydrolase active on para-nitrophenyl-β-d-xylopyranoside (pNPX), para-nitrophenyl-α-L-arabinofuranoside (pNPA), β-(1 → 4)-xylopyranosyl oligomers (XOS) of degree of polymerisation (DP) 2–4, and birchwood xylan. A phylogenetic tree of the 92 characterised GH43 enzymes displayed five distinct groups...

Measurement of ${\\mathcal B}(B^0_s\\rightarrow D_s^{(*)}D_s^{(*)})$ > and the Lifetime Difference in the $B_s^0$ System

Energy Technology Data Exchange (ETDEWEB)

Youn, Sungwoo [Northwestern Univ., Evanston, IL (United States)

2009-06-01

We search for the semi-inclusive process $B^0_s\\rightarrow D_s^{(*)}D_s^{(*)}$ using 2.8 fb$^{-1}$ of $p \\bar{p}$ collisions at $\\sqrt{s} = 1.96$ TeV recorded by the D0 detector operating at the Fermilab Tevatron Collider. Under certain theoretical assumptions, these double-charm final states saturate CP-even eigenstates in the $B_s^0$ decays, allowing the lifetime difference of the $B_s^0$ system to be related to the branching ratio. We observe $26.6\\pm 8.4$ signal events with a significance above background of 3.2 standard deviations. The branching ratio is measured as ${\\cal B}(B^0_s\\rightarrow D_s^{(*)}D_s^{(*)}) = 0.035\\pm0.010\\text{(stat)}\\pm0.011\\text{(syst)}$ and, in the Standard Model, the width difference is derived as $\\Delta \\Gamma_s^{\\rm CP}/\\Gamma_s = 0.072\\pm0.021\\text{(stat)}\\pm0.022\\text{(syst)}$.

Disc structure and variability in dwarf novae

Science.gov (United States)

Harlaftis, Emilios Theofanus

An introduction is given to dwarf novae reviewing the current research status in the field. We present IUE observations of Z Cha which support the mass transfer instability as the cause of the superoutbursts observed in SU UMa type dwarf novae. Comparison between the superoutburst and a normal outburst of Z Cha shows that the disc is flatter and has significantly less azimuthal structure than during superoutburst. Z Cha exhibits a soft x-ray deficit during superoutburst compared to OY Car. We find that the secondary star of Z Cha contributes approximately 30 percent of the infrared flux at peak of outburst. The second part of the thesis presents results from the 1988 International Time Project at the Observatorio del Roque de los Muchachos. Investigation of the behavior of SU UMa and YZ Cnc is carried out through the outburst cycle. The secular changes of the equivalent widths of both systems shows an increasing trend even during quiescence and are caused by the continuum decrease. Both systems show a low-velocity emission component which contaminates the wings of the H(alpha) profile. In addition to doppler broadening, the Stark effect is found to cause significant broadening to the line profile. The radial dependence of the emission lines is discussed in relation to other cataclysmic variables. H(alpha) emission from the secondary star of YZ Cnc is found during superoutburst, during outburst and during quiescence after outburst. Photometry during late decline of outburst shows a sinusoidal, weak variation peaking at 0.5 orbital phase and which is related to heating of the red star or to a transient disc event. During quiescence, the flickering is found to be caused by the bright spot. This modulation increases with time and is maximum before the outburst. Doppler tomography of IP Peg during quiescence reveals an emission line distribution not consistent to the standard model. We find Balmer emission from the secondary star, at a level of only 2.5 percent of the

Discovery of proteins involved in the interaction between prebiotics carbohydrates and probiotics & whole proteome analysis of the probiotic strain Bifidobacterium animalis susp. lactis BB-12

DEFF Research Database (Denmark)

Gilad, Ofir

Probiotic bacteria, which primarily belong to the genera Lactobascillus and Bifidobacterium, are live microorganisms that have been related to a variety of health-promoting effects. Prebiotics are indigestible food components that specifically stimulate the growth of probiotic organisms...... in the human gastrointestinal tract. Despite an increased scientific focus within this field, the mechanisms behind the beneficial effects exerted by pre- and probiotics are still far from fully understood. The purpose of the present industrial-PhD project was to identify proteins involved in interactions...... between the widely-used, extensively-studied probiotic strain Bifidobacterium animalis subsp. lactis BB-12 and potentially-prebiotic carbohydrates. The project was initiated with a screening phase in which more than 40 carbohydrates were tested for their ability to promote the growth of the bacterium...

The Impact of Uncertainties in African Biomass Burning Emission Estimates on Modeling Global Air Quality, Long Range Transport and Tropospheric Chemical Lifetimes

Directory of Open Access Journals (Sweden)

Guido R. van der Werf

2012-02-01

Full Text Available The chemical composition of the troposphere in the tropics and Southern Hemisphere (SH is significantly influenced by gaseous emissions released from African biomass burning (BB. Here we investigate how various emission estimates given in bottom-up BB inventories (GFEDv2, GFEDv3, AMMABB affect simulations of global tropospheric composition using the TM4 chemistry transport model. The application of various model parameterizations for introducing such emissions is also investigated. There are perturbations in near-surface ozone (O3 and carbon monoxide (CO of ~60–90% in the tropics and ~5–10% in the SH between different inventories. Increasing the update frequency of the temporal distribution to eight days generally results in decreases of between ~5 and 10% in near-surface mixing ratios throughout the tropics, which is larger than the influence of increasing the injection heights at which BB emissions are introduced. There are also associated differences in the long range transport of pollutants throughout the SH, where the composition of the free troposphere in the SH is sensitive to the chosen BB inventory. Analysis of the chemical budget terms reveals that the influence of increasing the tropospheric CO burden due to BB on oxidative capacity of the troposphere is mitigated by the associated increase in NOx emissions (and thus O3 with the variations in the CO/N ratio between inventories being low. For all inventories there is a decrease in the tropospheric chemical lifetime of methane of between 0.4 and 0.8% regardless of the CO emitted from African BB. This has implications for assessing the effect of inter-annual variability in BB on the annual growth rate of methane.

BMI, Income, and Social Capital in a Native Amazonian Society: Interaction between Relative and Community Variables

Czech Academy of Sciences Publication Activity Database

Brabec, Marek; Godoy, R.; Reyes-García, V.; Leonard, W.E.

2007-01-01

Roč. 19, č. 4 (2007), s. 459-474 ISSN 1042-0533 Institutional research plan: CEZ:AV0Z10300504 Keywords : BMI * economic factors * social capital * interaction models * separation of hierarchical effects * random effects models Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 1.805, year: 2007

The White Dwarf Mass and the Accretion Rate of Recurrent Novae: An X-ray Perspective

Science.gov (United States)

Mukai, Koji; Sokoloski, Jennifer L.; Nelson, Thomas; Luna, Gerardo J. M.

2011-01-01

We present recent results of quiescent X-ray observations of recurrent novae (RNe) and related objects. Several RNe are luminous hard X-ray sources in quiescence, consistent with accretion onto a near Chandrasekhar mass white dwarf. Detection of similar hard X-ray emissions in old novae and other cataclysmic variables may lead to identification of additional RN candidates. On the other hand, other RNe are found to be comparatively hard X-ray faint. We present several scenarios that may explain this dichotomy, which should be explored further.

Using variants of CHC Algorithms in the Design of Radio Frequency Networks in Wireless Communications.

Directory of Open Access Journals (Sweden)

Daniel Antonio Molina

2015-09-01

Full Text Available In this paper we apply to solve the Radio Network Design problem (RND a series  of the non-conventional genetic algorithms called Cross generational elitist selection Heterogeneous recombination Cataclysmic mutation (CHC. A set of genetic algorithms is used to perform a comparative performance of the proposed algorithms. An objective function based on signal coverage efficiency is used. Genetic variability of the population is used for both, as a parameter of convergence and detection of incest. Furthermore the variability of the best individual is proposed as a shaking mechanism. This allows generating dynamic populations according to the most promising solutions generating different search spaces. The results obtained by the proposed algorithms are satisfactory.

Infrared observations of AE Aquarii

Science.gov (United States)

Tanzi, E. G.; Chincarini, G.; Tarenghi, M.

1981-01-01

Broadband infrared observations of the cataclysmic variable AE Aquarii are reported. The observations were obtained in the J, H, K and L filters with the InSb photometer attached to the 1-m telescope of the European Southern Observatory. The infrared energy distribution observed from 0.35 to 3.5 microns for phase 0.5 suggests a spectral type of K5 V for the secondary and a distance to the system of approximately 70 pc if an absolute magnitude of 7.3 is assumed. Monitoring of the flux at 2.2 microns reveals a variability with an amplitude of approximately 0.3 magnitude over one third of the orbital period, the nature of which is under investigation.

Computing Cosmic Cataclysms

Science.gov (United States)

Centrella, Joan M.

2010-01-01

The final merger of two black holes releases a tremendous amount of energy, more than the combined light from all the stars in the visible universe. This energy is emitted in the form of gravitational waves, and observing these sources with gravitational wave detectors requires that we know the pattern or fingerprint of the radiation emitted. Since black hole mergers take place in regions of extreme gravitational fields, we need to solve Einstein's equations of general relativity on a computer in order to calculate these wave patterns. For more than 30 years, scientists have tried to compute these wave patterns. However, their computer codes have been plagued by problems that caused them to crash. This situation has changed dramatically in the past few years, with a series of amazing breakthroughs. This talk will take you on this quest for these gravitational wave patterns, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed.

Search for supersymmetric Higgs bosons in the Aleph experiment; Recherche de bosons de higgs supersymetriques dans l'experience ALEPH

Energy Technology Data Exchange (ETDEWEB)

Tuchming, B

2000-04-25

A search for the neutral Higgs bosons of the standard model and its minimal supersymmetric extension (MSSM) is performed in the four-jet channels, e{sup +}e{sup -} {yields} hZ {yields} qq-bar bb-bar and e{sup +}e{sup -} {yields} hA {yields} bb-bar bb-bar. To this end, the data collected in the ALEPH detector at LEP in 1998 and 1999 at centre-of-mass energies from 189 GeV up to 202 GeV is analyzed. Both selections rely upon the tagging of b quarks which is performed with the help of a neural network which combines the accurate reconstruction of the charged particle tracks, the lepton transverse momentum and the jet kinematics. Topological and kinematical variables which characterize the production of four jets are combined with the b content of the events to define the bb-bar bb-bar and the qq-bar bb-bar selections. When these analyses are applied on the ALEPH data, no evidence for a signal is observed. Therefore constraints are obtained on the mass of the standard model Higgs and on the MSSM parameter space. The following limit at 95% confidence level are established: m{sub h} > 107.4 GeV/c{sup 2} in the standard model and m{sub h} > 91.4 GeV/c{sup 2} in the MSSM. Moreover, for the benchmark set of MSSM parameters, the range 0.8 < tan {beta} < 1.9 and the infrared fixed point scenario at low tan {beta} are excluded. (author)

Field Trial Performance of Herculex XTRA (Cry34Ab1/Cry35Ab1) and SmartStax (Cry34Ab1/Cry35Ab1 + Cry3Bb1) Hybrids and Soil Insecticides Against Western and Northern Corn Rootworms (Coleoptera: Chrysomelidae).

Science.gov (United States)

Johnson, K D; Campbell, L A; Lepping, M D; Rule, D M

2017-06-01

Western corn rootworm, Diabrotica virgifera virgifera LeConte (Coleoptera: Chrysomelidae), and northern corn rootworm, Diabrotica barberi Smith and Lawrence (Coleoptera: Chrysomelidae), are important insect pests in corn, Zea mays L. For more than a decade, growers have been using transgenic plants expressing proteins from the bacterium Bacillus thuringiensis (Bt) to protect corn roots from feeding. In 2011, western corn rootworm populations were reported to have developed resistance to Bt hybrids expressing Cry3Bb1 and later found to be cross-resistant to hybrids expressing mCry3A and eCry3.1Ab. The identification of resistance to Cry3 (Cry3Bb1, mCry3A, and eCry3.1Ab) hybrids led to concerns about durability and efficacy of products with single traits and of products containing a pyramid of a Cry3 protein and the binary Bt proteins Cry34Ab1 and Cry35Ab1. From 2012 to 2014, 43 field trials were conducted across the central United States to estimate root protection provided by plants expressing Cry34Ab1/Cry35Ab1 alone (Herculex RW) or pyramided with Cry3Bb1 (SmartStax). These technologies were evaluated with and without soil-applied insecticides to determine if additional management measures provided benefit where Cry3 performance was reduced. Trials were categorized for analysis based on rootworm damage levels on Cry3-expressing hybrids and rootworm feeding pressure within each trial. Across scenarios, Cry34Ab1/Cry35Ab1 hybrids provided excellent root protection. Pyramided traits provided greater root and yield protection than non-Bt plus a soil-applied insecticide, and only in trials where larval feeding pressure exceeded two nodes of damage did Cry34Ab1/Cry35Ab1 single-trait hybrids and pyramided hybrids show greater root protection from the addition of soil-applied insecticides. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

A Generally Applicable Computer Algorithm Based on the Group Additivity Method for the Calculation of Seven Molecular Descriptors: Heat of Combustion, LogPO/W, LogS, Refractivity, Polarizability, Toxicity and LogBB of Organic Compounds; Scope and Limits of Applicability

Directory of Open Access Journals (Sweden)

Rudolf Naef

2015-10-01

Full Text Available A generally applicable computer algorithm for the calculation of the seven molecular descriptors heat of combustion, logPoctanol/water, logS (water solubility, molar refractivity, molecular polarizability, aqueous toxicity (protozoan growth inhibition and logBB (log (cblood/cbrain is presented. The method, an extendable form of the group-additivity method, is based on the complete break-down of the molecules into their constituting atoms and their immediate neighbourhood. The contribution of the resulting atom groups to the descriptor values is calculated using the Gauss-Seidel fitting method, based on experimental data gathered from literature. The plausibility of the method was tested for each descriptor by means of a k-fold cross-validation procedure demonstrating good to excellent predictive power for the former six descriptors and low reliability of logBB predictions. The goodness of fit (Q2 and the standard deviation of the 10-fold cross-validation calculation was >0.9999 and 25.2 kJ/mol, respectively, (based on N = 1965 test compounds for the heat of combustion, 0.9451 and 0.51 (N = 2640 for logP, 0.8838 and 0.74 (N = 1419 for logS, 0.9987 and 0.74 (N = 4045 for the molar refractivity, 0.9897 and 0.77 (N = 308 for the molecular polarizability, 0.8404 and 0.42 (N = 810 for the toxicity and 0.4709 and 0.53 (N = 383 for logBB. The latter descriptor revealing a very low Q2 for the test molecules (R2 was 0.7068 and standard deviation 0.38 for N = 413 training molecules is included as an example to show the limits of the group-additivity method. An eighth molecular descriptor, the heat of formation, was indirectly calculated from the heat of combustion data and correlated with published experimental heat of formation data with a correlation coefficient R2 of 0.9974 (N = 2031.

On the formation of TW Crv optical radiation

Science.gov (United States)

Shimansky, V. V.; Mitrofanova, A. A.; Borisov, N. V.; Fabrika, S. N.; Galeev, A. I.

2016-10-01

We present the analysis of the optical radiation of the young pre-cataclysmic variable TW Crv. Spectroscopic and photometric observations were obtained at the SAO RAS 6-m BTA telescope and at the Russian-Turkish RTT-150 telescope. The light curves of the system posses nearly sinusoidal shapes with the amplitudes of Δ m > 0.m7, what is typical for young pre-cataclysmic variables with sdO-subdwarfs and orbit inclinations of less than 45◦. The optical spectrum contains dominant radiation of the hot subdwarf with the HI and He II absorption lines and strong emission lines, which are formed in the atmosphere of the secondary owing to the reflection effects. Radial velocities of the cool star were measured by analyzing the λλ 4630-4650 Å Bowen blend, which for the first time allowed to determine the component masses. A numerical simulation of the light curves and spectra of TW Crv, obtaining a complete set of systems fundamental parameters was carried out. The hot star parameters prompt its belonging to the sdOsubdwarf class at the stage of transition to the cooling white dwarf sequence. The absence of its observable planetary nebula is caused by a long-lasting evolution of the system after the common envelope state. The secondary component has a luminosity excess, which is typical for other young sdO-subdwarf precataclysmic variables. Its position on the " age-luminosity excess" diagram points at the accuracy of the obtained set of TW Crv fundamental parameters and at the similarity of its evolutionary and physical conditions with that of other BE UMa-type objects.

Double-parton scattering effects in D0B+ and B+B+ meson-meson pair production in proton-proton collisions at the LHC

Science.gov (United States)

Maciuła, Rafał; Szczurek, Antoni

2018-05-01

We extend our previous studies of double-parton scattering (DPS) to simultaneous production of c c ¯ and b b ¯ and production of two pairs of b b ¯. The calculation is performed within a factorized ansatz. Each parton scattering is calculated within the kT-factorization approach. The hadronization is done with the help of fragmentation functions. Production of D mesons in our framework was tested in our previous works. Here, we present our predictions for B mesons. A good agreement is achieved with the LHCb data. We present our results for c c ¯b b ¯ and b b ¯b b ¯ final states. For completeness, we compare results for double- and single-parton scattering (SPS). As for the c c ¯c c ¯ final state, the DPS dominates over the SPS, especially for small transverse momenta. We present several distributions and integrated cross sections with realistic cuts for simultaneous production of D0B+ and B+B+, suggesting future experimental studies at the LHC.

An analysis of feature relevance in the classification of astronomical transients with machine learning methods

Science.gov (United States)

D'Isanto, A.; Cavuoti, S.; Brescia, M.; Donalek, C.; Longo, G.; Riccio, G.; Djorgovski, S. G.

2016-04-01

The exploitation of present and future synoptic (multiband and multi-epoch) surveys requires an extensive use of automatic methods for data processing and data interpretation. In this work, using data extracted from the Catalina Real Time Transient Survey (CRTS), we investigate the classification performance of some well tested methods: Random Forest, MultiLayer Perceptron with Quasi Newton Algorithm and K-Nearest Neighbours, paying special attention to the feature selection phase. In order to do so, several classification experiments were performed. Namely: identification of cataclysmic variables, separation between galactic and extragalactic objects and identification of supernovae.

Recent advances on the formation and evolution of white dwarfs

International Nuclear Information System (INIS)

Sion, E.M.

1986-01-01

Advances made in the past seven years in both the theory and observation of white dwarfs which have led to major progress in understanding white dwarf formation and evolution are reviewed. The roles of convective dredge-up, mixing and dilution, accretion, gravitational and thermal diffusion in dense plasmas, radiate forces and mass outflow, nuclear shell burning, diffusion-induced reactions, late thermonuclear shell flashes, rotation, and magnetic fields in white dwarf evolution are considered. Recent work on the properties of white dwarfs in cataclysmic variables is briefly addressed. 153 references

Investigation of high-energy sources in optical light by ESA Gaia

Czech Academy of Sciences Publication Activity Database

Hudec, R.; Šimon, Vojtěch; Hudec, L.; Hudcová, Věra

2010-01-01

Roč. 81, č. 1 (2010), s. 476-481 ISSN 0037-8720. [Multifrequency behaviour of high energy cosmic sources. Vulcano, 25.05.2009-30.05. 2009] R&D Projects: GA ČR GA205/08/1207 Grant - others:ESA(XE) ESA- PECS project No. 98058; GA ČR(CZ) GA102/09/0997; GA MŠk(CZ) ME09027; ESA(XE) ESA- PECS project No. 98023 Institutional research plan: CEZ:AV0Z10030501 Keywords : high-energy sources * cataclysmic variables * low-dispersion spectra Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

The evolutionary status of symbiotic stars

International Nuclear Information System (INIS)

Rudak, B.

1982-01-01

The evolutionary relations between symbiotic stars and cataclysmic variables are presented. The symbiotic stars are assumed to be long period detached binaries containing a carbon-oxygen degenerate primary and a red giant losing its mass through a spherically symmetric wind. Such systems can be obtained in Case C evolution, provided a common envelope during a rapid mass transfer phase was not formed. The same way recurrent novae containing a red giant as a secondary component may be produced. The factors influencing the differences between symbiotic stars and nova-type stars are discussed. (Auth.)

Use of the Wii Gaming System for Balance Rehabilitation: Establishing Parameters for Healthy Individuals.

Science.gov (United States)

Burns, Melissa K; Andeway, Kathleen; Eppenstein, Paula; Ruroede, Kathleen

2014-06-01

This study was designed to establish balance parameters for the Nintendo(®) (Redmond, WA) "Wii Fit™" Balance Board system with three common games, in a sample of healthy adults, and to evaluate the balance measurement reproducibility with separation by age. This was a prospective, multivariate analysis of variance, cohort study design. Seventy-five participants who satisfied all inclusion criteria and completed an informed consent were enrolled. Participants were grouped into age ranges: 21-35 years (n=24), 36-50 years (n=24), and 51-65 years (n=27). Each participant completed the following games three consecutive times, in a randomized order, during one session: "Balance Bubble" (BB) for distance and duration, "Tight Rope" (TR) for distance and duration, and "Center of Balance" (COB) on the left and right sides. COB distributed weight was fairly symmetrical across all subjects and trials; therefore, no influence was assumed on or interaction with other "Wii Fit" measurements. Homogeneity of variance statistics indicated the assumption of distribution normality of the dependent variables (rates) were tenable. The multivariate analysis of variance included dependent variables BB and TR rates (distance divided by duration to complete) with age group and trials as the independent variables. The BB rate was statistically significant (F=4.725, PWii Fit" can discriminate among age groups across trials. The results show promise as a viable tool to measure balance and distance across time (speed) and center of balance distribution.

WIND VARIABILITY IN BZ CAMELOPARDALIS

International Nuclear Information System (INIS)

Honeycutt, R. K.; Kafka, S.; Robertson, J. W.

2013-01-01

Sequences of spectra of the nova-like cataclysmic variable (CV) BZ Cam were acquired on nine nights in 2005-2006 in order to study the time development of episodes of wind activity known to occur frequently in this star. We confirm the results of Ringwald and Naylor that the P-Cygni absorption components of the lines mostly evolve from higher expansion velocity to lower velocity as an episode progresses. We also commonly find blueshifted emission components in the Hα line profile, whose velocities and durations strongly suggest that they are also due to the wind. Curiously, Ringwald and Naylor reported common occurrences of redshifted Hα emission components in their BZ Cam spectra. We have attributed these emission components in Hα to occasions when gas concentrations in the bipolar wind (both front side and back side) become manifested as emission lines as they move beyond the disk's outer edge. We also suggest, based on changes in the P-Cygni profiles during an episode, that the progression from larger to smaller expansion velocities is due to the higher velocity portions of a wind concentration moving beyond the edge of the continuum light of the disk first, leaving a net redward shift of the remaining absorption profile. We derive a new orbital ephemeris for BZ Cam, using the radial velocity of the core of the He I λ5876 line, finding P = 0.15353(4). Using this period, the wind episodes in BZ Cam are found to be concentrated near the inferior conjunction of the emission line source. This result helps confirm that the winds in nova-like CVs are often phase dependent, in spite of the puzzling implication that such winds lack axisymmetry. We argue that the radiation-driven wind in BZ Cam receives an initial boost by acting on gas that has been lifted above the disk by the interaction of the accretion stream with the disk, thereby imposing flickering timescales onto the wind events, as well as leading to an orbital modulation of the wind due to the non

Backyard Telescopes Watch an Expanding Binary

Science.gov (United States)

Kohler, Susanna

2018-01-01

What can you do with a team of people armed with backyard telescopes and a decade of patience? Test how binary star systems evolve under Einsteins general theory of relativity!Unusual VariablesCataclysmic variables irregularly brightening binary stars consisting of an accreting white dwarf and a donor star are a favorite target among amateur astronomers: theyre detectable even with small telescopes, and theres a lot we can learn about stellar astrophysics by observing them, if were patient.Diagram of a cataclysmic variable. In an AM CVn, the donor is most likely a white dwarf as well, or a low-mass helium star. [Philip D. Hall]Among the large family of cataclysmic variables is one unusual type: the extremely short-period AM Canum Venaticorum (AM CVn) stars. These rare variables (only 40 are known) are unique in having spectra dominated by helium, suggesting that they contain little or no hydrogen. Because of this, scientists have speculated that the donor stars in these systems are either white dwarfs themselves or very low-mass helium stars.Why study AM CVn stars? Because their unusual configuration allows us to predict the behavior of their orbital evolution. According to the general theory of relativity, the two components of an AM CVn will spiral closer and closer as the system loses angular momentum to gravitational-wave emission. Eventually they will get so close that the low-mass companion star overflows its Roche lobe, beginning mass transfer to the white dwarf. At this point, the orbital evolution will reverse and the binary orbit will expand, increasing its period.CBA member Enrique de Miguel, lead author on the study, with his backyard telescope in Huelva, Spain. [Enrique de Miguel]Backyard Astronomy Hard at WorkMeasuring the evolution of an AM CVns orbital period is the best way to confirm this model, but this is no simple task! To observe this evolution, we first need a system with a period that can be very precisely measured best achieved with an

Classification of X-ray sources in the XMM-Newton serendipitous source catalog: Objects of special interest

Energy Technology Data Exchange (ETDEWEB)

Lin, Dacheng; Webb, Natalie A.; Barret, Didier, E-mail: dlin@ua.edu [CNRS, IRAP, 9 Avenue du Colonel Roche, BP 44346, F-31028 Toulouse Cedex 4 (France)

2014-01-01

We analyze 18 sources that showed interesting properties of periodicity, very soft spectra, and/or large long-term variability in X-rays in our project of classification of sources from the 2XMMi-DR3 catalog, but were poorly studied in the literature, in order to investigate their nature. Two hard sources show X-ray periodicities of ∼1.62 hr (2XMM J165334.4–414423) and ∼2.1 hr (2XMM J133135.2–315541) and are probably magnetic cataclysmic variables. One source, 2XMM J123103.2+110648, is an active galactic nucleus (AGN) candidate showing very soft X-ray spectra (kT ∼ 0.1 keV) and exhibiting an intermittent ∼3.8 hr quasi-periodic oscillation. There are six other very soft sources (with kT < 0.2 keV), which might be in other galaxies with luminosities between ∼10{sup 38}-10{sup 42} erg s{sup –1}. They probably represent a diverse group that might include objects such as ultrasoft AGNs and cool thermal disk emission from accreting intermediate-mass black holes. Six highly variable sources with harder spectra are probably in nearby galaxies with luminosities above 10{sup 37} erg s{sup –1} and thus are great candidates for extragalactic X-ray binaries. One of them (2XMMi J004211.2+410429, in M31) is probably a new-born persistent source, having been X-ray bright and hard in 0.3-10 keV for at least four years since it was discovered entering an outburst in 2007. Three highly variable hard sources appear at low galactic latitudes and have maximum luminosities below ∼10{sup 34} erg s{sup –1} if they are in our Galaxy. Thus, they are great candidates for cataclysmic variables or very faint X-ray transients harboring a black hole or neutron star. Our interpretations of these sources can be tested with future long-term X-ray monitoring and multi-wavelength observations.

Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood–brain barrier model for drug permeability studies

OpenAIRE

Eigenmann, Daniela E; Xue, Gongda; Kim, Kwang S; Moses, Ashlee V; Hamburger, Matthias; Oufir, Mouhssin

2013-01-01

Background: Reliable human in vitro blood brain barrier (BBB) models suitable for high throughput screening are urgently needed in early drug discovery and development for assessing the ability of promising bioactive compounds to overcome the BBB. To establish an improved human in vitro BBB model we compared four currently available and well characterized immortalized human brain capillary endothelial cell lines hCMEC/D3 hBMEC TY10 and BB19 with respect to barrier tightness and paracellular p...

Rating of Perceived Exertion and Physiological Responses in Water-Based Exercise

Directory of Open Access Journals (Sweden)

Santana Pinto Stephanie

2015-12-01

Full Text Available The aim of the present study was to relate the overall rating of perceived exertion (RPE-overall with cardiorespiratory and neuromuscular variables during stationary running with the elbow flexion/extension performed with water-floating equipment. The sample consisted of eleven women that performed the water-based exercise at submaximal cadences. The heart rate, oxygen uptake, ventilation, and electromyographic signal (EMG from biceps brachii (%EMG BB, triceps brachii (%EMG TB, biceps femoris (%EMG BF and rectus femoris (%EMG RF muscles were measured during the exercise, and the overall RPE was measured immediately following its completion. The Pearson product-moment linear correlation was used to investigate associations between the variables analyzed in the present study. Significant relationships were observed between the RPE-overall and all the cardiorespiratory variables, with the r values ranging from 0.60 to 0.70 (p<0.05. In addition, the RPE-overall showed a significant (p<0.05 relationship with %EMG BB (r=0.55 and %EMG BF (r=0.50. These results suggest an association between the RPE-overall with all cardiorespiratory and two neuromuscular variables during the execution of a water-based aerobic exercise using water-floating equipment.

Search for Higgs bosons decaying to bb and produced in association with W bosons in pp collisions at square root of s = 1.96 TeV.

Science.gov (United States)

Abulencia, A; Acosta, D; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J-F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Ben-Haim, E; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Bourov, S; Boveia, A; Brau, B; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carron, S; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chapman, J; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Chu, P H; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Connolly, A; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Cruz, A; Cuevas, J; Culbertson, R; Cyr, D; DaRonco, S; D'Auria, S; D'onofrio, M; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'Orso, M; Demers, S; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Dionisi, C; Dittmann, J R; DiTuro, P; Dörr, C; Dominguez, A; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Ebina, K; Efron, J; Ehlers, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Flores-Castillo, L R; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Fujii, Y; Furic, I; Gajjar, A; Gallinaro, M; Galyardt, J; Garcia, J E; Garcia Sciverez, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerchtein, E; Gerdes, D; Giagu, S; di Giovanni, G P; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giokaris, N; Giolo, K; Giordani, M; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Y; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Haber, C; Hahn, S R; Hahn, K; Halkiadakis, E; Hamilton, A; Han, B-Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hatakeyama, K; Hauser, J; Hays, C; Hayward, H; Heijboer, A; Heinemann, B; Heinrich, J; Hennecke, M; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Huston, J; Ikado, K; Incandela, J; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, Y K; Kirby, M; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kobayashi, H; Kondo, K; Kong, D J; Konigsberg, J; Kordas, K; Korytov, A; Kotwal, A V; Kovalev, A; Kraus, J; Kravchenko, I; Kreps, M; Kreymer, A; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecci, C; LeCompte, T; Lee, J; Lee, J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Li, K; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Liss, T M; Lister, A; Litvintsev, D O; Liu, T; Liu, Y; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Maksimovic, P; Manca, G; Margaroli, F; Marginean, R; Marino, C; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P; McNamara, P; McNulty, R; Mehta, A; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; von der Mey, M; Miao, T; Miladinovic, N; Miles, J; Miller, R; Miller, J S; Mills, C; Milnik, M; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Mulhearn, M; Muller, Th; Mumford, R; Murat, P; Nachtman, J; Nahn, S; Nakano, I; Napier, A; Naumov, D; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Ogawa, T; Oh, S H; Oh, Y D; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagliarone, C; Palencia, E; Paoletti, R; Papadimitriou, V; Papikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pitts, K; Plager, C; Pondrom, L; Pope, G; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Rakitin, A; Rappoccio, S; Ratnikov, F; Reisert, B; Rekovic, V; van Remortel, N; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Rinnert, K; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Rott, C; Ruiz, A; Russ, J; Rusu, V; Ryan, D; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Salto, O; Saltzberg, D; Sanchez, C; Santi, L; Sarkar, S; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sill, A; Sinervo, P; Sisakyan, A; Sjolin, J; Skiba, A; Slaughter, A J; Sliwa, K; Smirnov, D; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Taffard, A; Tafirout, R; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Tönnesmann, M; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, A; Vallecorsa, S; Varganov, A; Vataga, E; Velev, G; Veramendi, G; Veszpremi, V; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vollrath, I; Volobouev, I; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Wan, Z; Wang, M J; Wang, S M; Warburton, A; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Worm, S; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, Y; Yang, C; Yang, U K; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhang, X; Zhou, J; Zucchelli, S

2006-03-03

We present a search for Higgs bosons decaying into bb and produced in association with W bosons in pp collisions at square root of s = 1.96 TeV. This search uses 320 pb(-1) of the data set accumulated by the upgraded Collider Detector at Fermilab. Events are selected that have a high-transverse momentum electron or muon, missing transverse energy, and two jets, at least one of which is consistent with the hadronization of a b quark. Both the number of events and the dijet mass distribution are consistent with standard model background expectations, and we set 95% confidence level upper limits on the production cross section times branching ratio for the Higgs boson or any new particle with similar decay kinematics. These upper limits range from 10 pb for mH = 110 GeV/c2 to 3 pb for mH = 150 GeV/c2.

ORIGIN OF THE GALACTIC DIFFUSE X-RAY EMISSION: IRON K-SHELL LINE DIAGNOSTICS

Energy Technology Data Exchange (ETDEWEB)

Nobukawa, Masayoshi [Department of Teacher Training and School Education, Nara University of Education, Takabatake-cho, Nara, 630-8528 (Japan); Uchiyama, Hideki [Faculty of Education, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529 (Japan); Nobukawa, Kumiko K.; Koyama, Katsuji [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwake-cho, Sakyo-ku, Kyoto, 606-8502 (Japan); Yamauchi, Shigeo, E-mail: nobukawa@nara-edu.ac.jp [Department of Physics, Nara Women’s University, Kitauoyanishimachi, Nara, 630-8506 (Japan)

2016-12-20

This paper reports detailed K-shell line profiles of iron (Fe) and nickel (Ni) of the Galactic Center X-ray Emission (GCXE), Galactic Bulge X-ray Emission (GBXE), Galactic Ridge X-ray Emission (GRXE), magnetic Cataclysmic Variables (mCVs), non-magnetic Cataclysmic Variables (non-mCVs), and coronally Active Binaries (ABs). For the study of the origin of the GCXE, GBXE, and GRXE, the spectral analysis is focused on equivalent widths of the Fe i-K α , Fe xxv-He α , and Fe xxvi-Ly α  lines. The global spectrum of the GBXE is reproduced by a combination of the mCVs, non-mCVs, and ABs spectra. On the other hand, the GRXE spectrum shows significant data excesses at the Fe i-K α and Fe xxv-He α  line energies. This means that additional components other than mCVs, non-mCVs, and ABs are required, which have symbiotic phenomena of cold gas and very high-temperature plasma. The GCXE spectrum shows larger excesses than those found in the GRXE spectrum at all the K-shell lines of iron and nickel. Among them the largest ones are the Fe i-K α , Fe xxv-He α , Fe xxvi-Ly α , and Fe xxvi-Ly β  lines. Together with the fact that the scale heights of the Fe i-K α , Fe xxv-He α , and Fe xxvi-Ly α lines are similar to that of the central molecular zone (CMZ), the excess components would be related to high-energy activity in the extreme envelopment of the CMZ.

Synthesis, magnetic properties and Moessbauer spectroscopy for the pyrochlore family Bi{sub 2}BB Prime O{sub 7} with B=Cr and Fe and B Prime =Nb, Ta and Sb

Energy Technology Data Exchange (ETDEWEB)

Blanco, Maria C. [INFIQC (CONICET), Dpto. de Fisicoquimica, Fac. de Ciencias Quimicas, U.N.C., Cordoba (X5000HUA) (Argentina); Franco, Diego G. [INFIQC (CONICET), Dpto. de Fisicoquimica, Fac. de Ciencias Quimicas, U.N.C., Cordoba (X5000HUA) (Argentina); Centro Atomico Bariloche - CNEA, Av. E. Bustillo 9500, S.C. de Bariloche (8500), R.N. (Argentina); Jalit, Yamile; Pannunzio Miner, Elisa V. [INFIQC (CONICET), Dpto. de Fisicoquimica, Fac. de Ciencias Quimicas, U.N.C., Cordoba (X5000HUA) (Argentina); Berndt, Graciele; Paesano, Andrea [Departamento de Fisica, Universidade Estadual de Maringa, Parana (Brazil); Nieva, Gladys [Centro Atomico Bariloche - CNEA, Av. E. Bustillo 9500, S.C. de Bariloche (8500), R.N. (Argentina); Carbonio, Raul E., E-mail: carbonio@mail.fcq.unc.edu.ar [INFIQC (CONICET), Dpto. de Fisicoquimica, Fac. de Ciencias Quimicas, U.N.C., Cordoba (X5000HUA) (Argentina)

2012-08-15

The samples Bi{sub 2}BB Prime O{sub 7}, with B=Cr and Fe and B Prime =Nb, Ta and Sb were prepared by solid state method. The crystallographic structure was investigated on the basis of X-ray powder diffraction data. Rietveld refinements show that the crystal structure is cubic, space group Fd-3m. The Bi{sup 3+} cation on the eight-coordinate pyrochlore A-site shows displacive disorder, as a consequence of its lone pair electron configuration. There is also a considerable A-site disorder shown by Rietveld Analysis and confirmed in the case of the iron containing samples with Moessbauer spectroscopy. The magnetic measurements show paramagnetic behavior at all temperatures for the Cr oxides. The Fe pyrochlores show antiferromagnetic order around 10 K.

Search for Dark Matter Produced in Association with a Higgs Boson Decaying to bb[over ¯] Using 36  fb^{-1} of pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Science.gov (United States)

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, S H; AbouZeid, O S; Abraham, N L; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, B S; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adye, T; Affolder, A A; Agatonovic-Jovin, T; Agheorghiesei, C; Aguilar-Saavedra, J A; Ahlen, S P; Ahmadov, F; Aielli, G; Akatsuka, S; Akerstedt, H; Åkesson, T P A; Akilli, E; Akimov, A V; Alberghi, G L; Albert, J; Albicocco, P; Alconada Verzini, M J; Alderweireldt, S C; Aleksa, M; Aleksandrov, I N; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Aliev, M; Alimonti, G; Alison, J; Alkire, S P; Allbrooke, B M M; Allen, B W; Allport, P P; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, A A; Alstaty, M I; Alvarez Gonzalez, B; Álvarez Piqueras, D; Alviggi, M G; Amadio, B T; Amaral Coutinho, Y; Amelung, C; Amidei, D; Amor Dos Santos, S P; Amorim, A; Amoroso, S; Amundsen, G; Anastopoulos, C; Ancu, L S; Andari, N; Andeen, T; Anders, C F; Anders, J K; Anderson, K J; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, A V; Anjos, N; Annovi, A; Antel, C; Antonelli, M; Antonov, A; Antrim, D J; Anulli, F; Aoki, M; Aperio Bella, L; Arabidze, G; Arai, Y; Araque, J P; Araujo Ferraz, V; Arce, A T H; Ardell, R E; Arduh, F A; Arguin, J-F; Argyropoulos, S; Arik, M; Armbruster, A J; Armitage, L J; Arnaez, O; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Artz, S; Asai, S; Asbah, N; Ashkenazi, A; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, N B; Augsten, K; Avolio, G; Axen, B; Ayoub, M K; Azuelos, G; Baas, A E; Baca, M J; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Bagnaia, P; Bahmani, M; Bahrasemani, H; Baines, J T; Bajic, M; Baker, O K; Baldin, E M; Balek, P; Balli, F; Balunas, W K; Banas, E; Bandyopadhyay, A; Banerjee, Sw; Bannoura, A A E; Barak, L; Barberio, E L; Barberis, D; Barbero, M; Barillari, T; Barisits, M-S; Barkeloo, J T; Barklow, T; Barlow, N; Barnes, S L; Barnett, B M; Barnett, R M; Barnovska-Blenessy, Z; Baroncelli, A; Barone, G; Barr, A J; Barranco Navarro, L; Barreiro, F; Barreiro Guimarães da Costa, J; Bartoldus, R; Barton, A E; Bartos, P; Basalaev, A; Bassalat, A; Bates, R L; Batista, S J; Batley, J R; Battaglia, M; Bauce, M; Bauer, F; Bawa, H S; Beacham, J B; Beattie, M D; Beau, T; Beauchemin, P H; Bechtle, P; Beck, H P; Beck, H C; Becker, K; Becker, M; Beckingham, M; Becot, C; Beddall, A J; Beddall, A; Bednyakov, V A; Bedognetti, M; Bee, C P; Beermann, T A; Begalli, M; Begel, M; Behr, J K; Bell, A S; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Belyaev, N L; Benary, O; Benchekroun, D; Bender, M; Bendtz, K; Benekos, N; Benhammou, Y; Benhar Noccioli, E; Benitez, J; Benjamin, D P; Benoit, M; Bensinger, J R; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Bergeaas Kuutmann, E; Berger, N; Beringer, J; Berlendis, S; Bernard, N R; Bernardi, G; Bernius, C; Bernlochner, F U; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertram, I A; Bertsche, C; Bertsche, D; Besjes, G J; Bessidskaia Bylund, O; Bessner, M; Besson, N; Betancourt, C; Bethani, A; Bethke, S; Bevan, A J; Beyer, J; Bianchi, R M; Biebel, O; Biedermann, D; Bielski, R; Bierwagen, K; Biesuz, N V; Biglietti, M; Billoud, T R V; Bilokon, H; Bindi, M; Bingul, A; Bini, C; Biondi, S; Bisanz, T; Bittrich, C; Bjergaard, D M; Black, C W; Black, J E; Black, K M; Blair, R E; Blazek, T; Bloch, I; Blocker, C; Blue, A; Blum, W; Blumenschein, U; Blunier, S; Bobbink, G J; Bobrovnikov, V S; Bocchetta, S S; Bocci, A; Bock, C; Boehler, M; Boerner, D; Bogavac, D; Bogdanchikov, A G; Bohm, C; Boisvert, V; Bokan, P; Bold, T; Boldyrev, A S; Bolz, A E; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Bortfeldt, J; Bortoletto, D; Bortolotto, V; Boscherini, D; Bosman, M; Bossio Sola, J D; Boudreau, J; Bouffard, J; Bouhova-Thacker, E V; Boumediene, D; Bourdarios, C; Boutle, S K; Boveia, A; Boyd, J; Boyko, I R; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, J E; Breaden Madden, W D; Brendlinger, K; Brennan, A J; Brenner, L; Brenner, R; Bressler, S; Briglin, D L; Bristow, T M; Britton, D; Britzger, D; Brochu, F M; Brock, I; Brock, R; Brooijmans, G; Brooks, T; Brooks, W K; Brosamer, J; Brost, E; Broughton, J H; Bruckman de Renstrom, P A; Bruncko, D; Bruni, A; Bruni, G; Bruni, L S; Brunt, B H; Bruschi, M; Bruscino, N; Bryant, P; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, A G; Budagov, I A; Buehrer, F; Bugge, M K; Bulekov, O; Bullock, D; Burch, T J; Burdin, S; Burgard, C D; Burger, A M; Burghgrave, B; Burka, K; Burke, S; Burmeister, I; Burr, J T P; Busato, E; Büscher, D; Büscher, V; Bussey, P; Butler, J M; Buttar, C M; Butterworth, J M; Butti, P; Buttinger, W; Buzatu, A; Buzykaev, A R; Cabrera Urbán, S; Caforio, D; Cairo, V M; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Callea, G; Caloba, L P; Calvente Lopez, S; Calvet, D; Calvet, S; Calvet, T P; Camacho Toro, R; Camarda, S; Camarri, P; Cameron, D; Caminal Armadans, R; Camincher, C; Campana, S; Campanelli, M; Camplani, A; Campoverde, A; Canale, V; Cano Bret, M; Cantero, J; Cao, T; Capeans Garrido, M D M; Caprini, I; Caprini, M; Capua, M; Carbone, R M; Cardarelli, R; Cardillo, F; Carli, I; Carli, T; Carlino, G; Carlson, B T; Carminati, L; Carney, R M D; Caron, S; Carquin, E; Carrá, S; Carrillo-Montoya, G D; Carvalho, J; Casadei, D; Casado, M P; Casolino, M; Casper, D W; Castelijn, R; Castillo Gimenez, V; Castro, N F; Catinaccio, A; Catmore, J R; Cattai, A; Caudron, J; Cavaliere, V; Cavallaro, E; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Celebi, E; Ceradini, F; Cerda Alberich, L; Cerqueira, A S; Cerri, A; Cerrito, L; Cerutti, F; Cervelli, A; Cetin, S A; Chafaq, A; Chakraborty, D; Chan, S K; Chan, W S; Chan, Y L; Chang, P; Chapman, J D; Charlton, D G; Chau, C C; Chavez Barajas, C A; Che, S; Cheatham, S; Chegwidden, A; Chekanov, S; Chekulaev, S V; Chelkov, G A; Chelstowska, M A; Chen, C; Chen, H; Chen, J; Chen, S; Chen, S; Chen, X; Chen, Y; Cheng, H C; Cheng, H J; Cheplakov, A; Cheremushkina, E; Cherkaoui El Moursli, R; Cheu, E; Cheung, K; Chevalier, L; Chiarella, V; Chiarelli, G; Chiodini, G; Chisholm, A S; Chitan, A; Chiu, Y H; Chizhov, M V; Choi, K; Chomont, A R; Chou, Y; Chouridou, S; Chow, Y S; Christodoulou, V; Chu, M C; Chudoba, J; Chuinard, A J; Chwastowski, J J; Chytka, L; Ciftci, A K; Cinca, D; Cindro, V; Cioara, I A; Ciocca, C; Ciocio, A; Cirotto, F; Citron, Z H; Citterio, M; Ciubancan, M; Clark, A; Clark, B L; Clark, M R; Clark, P J; Clarke, R N; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Colasurdo, L; Cole, B; Colijn, A P; Collot, J; Colombo, T; Conde Muiño, P; Coniavitis, E; Connell, S H; Connelly, I A; Constantinescu, S; Conti, G; Conventi, F; Cooke, M; Cooper-Sarkar, A M; Cormier, F; Cormier, K J R; Corradi, M; Corriveau, F; Cortes-Gonzalez, A; Cortiana, G; Costa, G; Costa, M J; Costanzo, D; Cottin, G; Cowan, G; Cox, B E; Cranmer, K; Crawley, S J; Creager, R A; Cree, G; Crépé-Renaudin, S; Crescioli, F; Cribbs, W A; Cristinziani, M; Croft, V; Crosetti, G; Cueto, A; Cuhadar Donszelmann, T; Cukierman, A R; Cummings, J; Curatolo, M; Cúth, J; Czekierda, S; Czodrowski, P; D'amen, G; D'Auria, S; D'eramo, L; D'Onofrio, M; Da Cunha Sargedas De Sousa, M J; Da Via, C; Dabrowski, W; Dado, T; Dai, T; Dale, O; Dallaire, F; Dallapiccola, C; Dam, M; Dandoy, J R; Daneri, M F; Dang, N P; Daniells, A C; Dann, N S; Danninger, M; Dano Hoffmann, M; Dao, V; Darbo, G; Darmora, S; Dassoulas, J; Dattagupta, A; Daubney, T; Davey, W; David, C; Davidek, T; Davis, D R; Davison, P; Dawe, E; Dawson, I; De, K; de Asmundis, R; De Benedetti, A; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Lorenzi, F; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; De Vasconcelos Corga, K; De Vivie De Regie, J B; Dearnaley, W J; Debbe, R; Debenedetti, C; Dedovich, D V; Dehghanian, N; Deigaard, I; Del Gaudio, M; Del Peso, J; Delgove, D; Deliot, F; Delitzsch, C M; Dell'Acqua, A; Dell'Asta, L; Dell'Orso, M; Della Pietra, M; Della Volpe, D; Delmastro, M; Delporte, C; Delsart, P A; DeMarco, D A; Demers, S; Demichev, M; Demilly, A; Denisov, S P; Denysiuk, D; Derendarz, D; Derkaoui, J E; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Devesa, M R; Deviveiros, P O; Dewhurst, A; Dhaliwal, S; Di Bello, F A; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, W K; Di Donato, C; Di Girolamo, A; Di Girolamo, B; Di Micco, B; Di Nardo, R; Di Petrillo, K F; Di Simone, A; Di Sipio, R; Di Valentino, D; Diaconu, C; Diamond, M; Dias, F A; Diaz, M A; Diehl, E B; Dietrich, J; Díez Cornell, S; Dimitrievska, A; Dingfelder, J; Dita, P; Dita, S; Dittus, F; Djama, F; Djobava, T; Djuvsland, J I; do Vale, M A B; Dobos, D; Dobre, M; Doglioni, C; Dolejsi, J; Dolezal, Z; Donadelli, M; Donati, S; Dondero, P; Donini, J; Dopke, J; Doria, A; Dova, M T; Doyle, A T; Drechsler, E; Dris, M; Du, Y; Duarte-Campderros, J; Dubreuil, A; Duchovni, E; Duckeck, G; Ducourthial, A; Ducu, O A; Duda, D; Dudarev, A; Dudder, A Chr; Duffield, E M; Duflot, L; Dührssen, M; Dumancic, M; Dumitriu, A E; Duncan, A K; Dunford, M; Duran Yildiz, H; Düren, M; Durglishvili, A; Duschinger, D; Dutta, B; Duvnjak, D; Dyndal, M; Dziedzic, B S; Eckardt, C; Ecker, K M; Edgar, R C; Eifert, T; Eigen, G; Einsweiler, K; Ekelof, T; El Kacimi, M; El Kosseifi, R; Ellajosyula, V; Ellert, M; Elles, S; Ellinghaus, F; Elliot, A A; Ellis, N; Elmsheuser, J; Elsing, M; Emeliyanov, D; Enari, Y; Endner, O C; Ennis, J S; Erdmann, J; Ereditato, A; Ernst, M; Errede, S; Escalier, M; Escobar, C; Esposito, B; Estrada Pastor, O; Etienvre, A I; Etzion, E; Evans, H; Ezhilov, A; Ezzi, M; Fabbri, F; Fabbri, L; Fabiani, V; Facini, G; Fakhrutdinov, R M; Falciano, S; Falla, R J; Faltova, J; Fang, Y; Fanti, M; Farbin, A; Farilla, A; Farina, C; Farina, E M; Farooque, T; Farrell, S; Farrington, S M; Farthouat, P; Fassi, F; Fassnacht, P; Fassouliotis, D; Faucci Giannelli, M; Favareto, A; Fawcett, W J; Fayard, L; Fedin, O L; Fedorko, W; Feigl, S; Feligioni, L; Feng, C; Feng, E J; Feng, H; Fenton, M J; Fenyuk, A B; Feremenga, L; Fernandez Martinez, P; Fernandez Perez, S; Ferrando, J; Ferrari, A; Ferrari, P; Ferrari, R; Ferreira de Lima, D E; Ferrer, A; Ferrere, D; Ferretti, C; Fiedler, F; Filipčič, A; Filipuzzi, M; Filthaut, F; Fincke-Keeler, M; Finelli, K D; Fiolhais, M C N; Fiorini, L; Fischer, A; Fischer, C; Fischer, J; Fisher, W C; Flaschel, N; Fleck, I; Fleischmann, P; Fletcher, R R M; Flick, T; Flierl, B M; Flores Castillo, L R; Flowerdew, M J; Forcolin, G T; Formica, A; Förster, F A; Forti, A; Foster, A G; Fournier, D; Fox, H; Fracchia, S; Francavilla, P; Franchini, M; Franchino, S; Francis, D; Franconi, L; Franklin, M; Frate, M; Fraternali, M; Freeborn, D; Fressard-Batraneanu, S M; Freund, B; Froidevaux, D; Frost, J A; Fukunaga, C; Fusayasu, T; Fuster, J; Gabaldon, C; Gabizon, O; Gabrielli, A; Gabrielli, A; Gach, G P; Gadatsch, S; Gadomski, S; Gagliardi, G; Gagnon, L G; Galea, C; Galhardo, B; Gallas, E J; Gallop, B J; Gallus, P; Galster, G; Gan, K K; Ganguly, S; Gao, Y; Gao, Y S; Garay Walls, F M; García, C; García Navarro, J E; García Pascual, J A; Garcia-Sciveres, M; Gardner, R W; Garelli, N; Garonne, V; Gascon Bravo, A; Gasnikova, K; Gatti, C; Gaudiello, A; Gaudio, G; Gavrilenko, I L; Gay, C; Gaycken, G; Gazis, E N; Gee, C N P; Geisen, J; Geisen, M; Geisler, M P; Gellerstedt, K; Gemme, C; Genest, M H; Geng, C; Gentile, S; Gentsos, C; George, S; Gerbaudo, D; Gershon, A; Geßner, G; Ghasemi, S; Ghneimat, M; Giacobbe, B; Giagu, S; Giangiacomi, N; Giannetti, P; Gibson, S M; Gignac, M; Gilchriese, M; Gillberg, D; Gilles, G; Gingrich, D M; Giokaris, N; Giordani, M P; Giorgi, F M; Giraud, P F; Giromini, P; Giugliarelli, G; Giugni, D; Giuli, F; Giuliani, C; Giulini, M; Gjelsten, B K; Gkaitatzis, S; Gkialas, I; Gkougkousis, E L; Gkountoumis, P; Gladilin, L K; Glasman, C; Glatzer, J; Glaysher, P C F; Glazov, A; Goblirsch-Kolb, M; Godlewski, J; Goldfarb, S; Golling, T; Golubkov, D; Gomes, A; Gonçalo, R; Goncalves Gama, R; Goncalves Pinto Firmino Da Costa, J; Gonella, G; Gonella, L; Gongadze, A; González de la Hoz, S; Gonzalez-Sevilla, S; Goossens, L; Gorbounov, P A; Gordon, H A; Gorelov, I; Gorini, B; Gorini, E; Gorišek, A; Goshaw, A T; Gössling, C; Gostkin, M I; Gottardo, C A; Goudet, C R; Goujdami, D; Goussiou, A G; Govender, N; Gozani, E; Graber, L; Grabowska-Bold, I; Gradin, P O J; Gramling, J; Gramstad, E; Grancagnolo, S; Gratchev, V; Gravila, P M; Gray, C; Gray, H M; Greenwood, Z D; Grefe, C; Gregersen, K; Gregor, I M; Grenier, P; Grevtsov, K; Griffiths, J; Grillo, A A; Grimm, K; Grinstein, S; Gris, Ph; Grivaz, J-F; Groh, S; Gross, E; Grosse-Knetter, J; Grossi, G C; Grout, Z J; Grummer, A; Guan, L; Guan, W; Guenther, J; Guescini, F; Guest, D; Gueta, O; Gui, B; Guido, E; Guillemin, T; Guindon, S; Gul, U; Gumpert, C; Guo, J; Guo, W; Guo, Y; Gupta, R; Gupta, S; Gustavino, G; Gutierrez, P; Gutierrez Ortiz, N G; Gutschow, C; Guyot, C; Guzik, M P; Gwenlan, C; Gwilliam, C B; Haas, A; Haber, C; Hadavand, H K; Haddad, N; Hadef, A; Hageböck, S; Hagihara, M; Hakobyan, H; Haleem, M; Haley, J; Halladjian, G; Hallewell, G D; Hamacher, K; Hamal, P; Hamano, K; Hamilton, A; Hamity, G N; Hamnett, P G; Han, L; Han, S; Hanagaki, K; Hanawa, K; Hance, M; Haney, B; Hanke, P; Hansen, J B; Hansen, J D; Hansen, M C; Hansen, P H; Hara, K; Hard, A S; Harenberg, T; Hariri, F; Harkusha, S; Harrington, R D; Harrison, P F; Hartmann, N M; Hasegawa, M; Hasegawa, Y; Hasib, A; Hassani, S; Haug, S; Hauser, R; Hauswald, L; Havener, L B; Havranek, M; Hawkes, C M; Hawkings, R J; Hayakawa, D; Hayden, D; Hays, C P; Hays, J M; Hayward, H S; Haywood, S J; Head, S J; Heck, T; Hedberg, V; Heelan, L; Heer, S; Heidegger, K K; Heim, S; Heim, T; Heinemann, B; Heinrich, J J; Heinrich, L; Heinz, C; Hejbal, J; Helary, L; Held, A; Hellman, S; Helsens, C; Henderson, R C W; Heng, Y; Henkelmann, S; Henriques Correia, A M; Henrot-Versille, S; Herbert, G H; Herde, H; Herget, V; Hernández Jiménez, Y; Herr, H; Herten, G; Hertenberger, R; Hervas, L; Herwig, T C; Hesketh, G G; Hessey, N P; Hetherly, J W; Higashino, S; Higón-Rodriguez, E; Hildebrand, K; Hill, E; Hill, J C; Hiller, K H; Hillier, S J; Hils, M; Hinchliffe, I; Hirose, M; Hirschbuehl, D; Hiti, B; Hladik, O; Hoad, X; Hobbs, J; Hod, N; Hodgkinson, M C; Hodgson, P; Hoecker, A; Hoeferkamp, M R; Hoenig, F; Hohn, D; Holmes, T R; Homann, M; Honda, S; Honda, T; Hong, T M; Hooberman, B H; Hopkins, W H; Horii, Y; Horton, A J; Hostachy, J-Y; Hou, S; Hoummada, A; Howarth, J; Hoya, J; Hrabovsky, M; Hrdinka, J; Hristova, I; Hrivnac, J; Hryn'ova, T; Hrynevich, A; Hsu, P J; Hsu, S-C; Hu, Q; Hu, S; Huang, Y; Hubacek, Z; Hubaut, F; Huegging, F; Huffman, T B; Hughes, E W; Hughes, G; Huhtinen, M; Huo, P; Huseynov, N; Huston, J; Huth, J; Iacobucci, G; Iakovidis, G; Ibragimov, I; Iconomidou-Fayard, L; Idrissi, Z; Iengo, P; Igonkina, O; Iizawa, T; Ikegami, Y; Ikeno, M; Ilchenko, Y; Iliadis, D; Ilic, N; Introzzi, G; Ioannou, P; Iodice, M; Iordanidou, K; Ippolito, V; Isacson, M F; Ishijima, N; Ishino, M; Ishitsuka, M; Issever, C; Istin, S; Ito, F; Iturbe Ponce, J M; Iuppa, R; Iwasaki, H; Izen, J M; Izzo, V; Jabbar, S; Jackson, P; Jacobs, R M; Jain, V; Jakobi, K B; Jakobs, K; Jakobsen, S; Jakoubek, T; Jamin, D O; Jana, D K; Jansky, R; Janssen, J; Janus, M; Janus, P A; Jarlskog, G; Javadov, N; Javůrek, T; Javurkova, M; Jeanneau, F; Jeanty, L; Jejelava, J; Jelinskas, A; Jenni, P; Jeske, C; Jézéquel, S; Ji, H; Jia, J; Jiang, H; Jiang, Y; Jiang, Z; Jiggins, S; Jimenez Pena, J; Jin, S; Jinaru, A; Jinnouchi, O; Jivan, H; Johansson, P; Johns, K A; Johnson, C A; Johnson, W J; Jon-And, K; Jones, R W L; Jones, S D; Jones, S; Jones, T J; Jongmanns, J; Jorge, P M; Jovicevic, J; Ju, X; Juste Rozas, A; Köhler, M K; Kaczmarska, A; Kado, M; Kagan, H; Kagan, M; Kahn, S J; Kaji, T; Kajomovitz, E; Kalderon, C W; Kaluza, A; Kama, S; Kamenshchikov, A; Kanaya, N; Kanjir, L; Kantserov, V A; Kanzaki, J; Kaplan, B; Kaplan, L S; Kar, D; Karakostas, K; Karastathis, N; Kareem, M J; Karentzos, E; Karpov, S N; Karpova, Z M; Karthik, K; Kartvelishvili, V; Karyukhin, A N; Kasahara, K; Kashif, L; Kass, R D; Kastanas, A; Kataoka, Y; Kato, C; Katre, A; Katzy, J; Kawade, K; Kawagoe, K; Kawamoto, T; Kawamura, G; Kay, E F; Kazanin, V F; Keeler, R; Kehoe, R; Keller, J S; Kellermann, E; Kempster, J J; Kendrick, J; Keoshkerian, H; Kepka, O; Kerševan, B P; Kersten, S; Keyes, R A; Khader, M; Khalil-Zada, F; Khanov, A; Kharlamov, A G; Kharlamova, T; Khodinov, A; Khoo, T J; Khovanskiy, V; Khramov, E; Khubua, J; Kido, S; Kilby, C R; Kim, H Y; Kim, S H; Kim, Y K; Kimura, N; Kind, O M; King, B T; Kirchmeier, D; Kirk, J; Kiryunin, A E; Kishimoto, T; Kisielewska, D; Kitali, V; Kiuchi, K; Kivernyk, O; Kladiva, E; Klapdor-Kleingrothaus, T; Klein, M H; Klein, M; Klein, U; Kleinknecht, K; Klimek, P; Klimentov, A; Klingenberg, R; Klingl, T; Klioutchnikova, T; Kluge, E-E; Kluit, P; Kluth, S; Kneringer, E; Knoops, E B F G; Knue, A; Kobayashi, A; Kobayashi, D; Kobayashi, T; Kobel, M; Kocian, M; Kodys, P; Koffas, T; Koffeman, E; Köhler, N M; Koi, T; Kolb, M; Koletsou, I; Komar, A A; Komori, Y; Kondo, T; Kondrashova, N; Köneke, K; König, A C; Kono, T; Konoplich, R; Konstantinidis, N; Kopeliansky, R; Koperny, S; Kopp, A K; Korcyl, K; Kordas, K; Korn, A; Korol, A A; Korolkov, I; Korolkova, E V; Kortner, O; Kortner, S; Kosek, T; Kostyukhin, V V; Kotwal, A; Koulouris, A; Kourkoumeli-Charalampidi, A; Kourkoumelis, C; Kourlitis, E; Kouskoura, V; Kowalewska, A B; Kowalewski, R; Kowalski, T Z; Kozakai, C; Kozanecki, W; Kozhin, A S; Kramarenko, V A; Kramberger, G; Krasnopevtsev, D; Krasny, M W; Krasznahorkay, A; Krauss, D; Kremer, J A; Kretzschmar, J; Kreutzfeldt, K; Krieger, P; Krizka, K; Kroeninger, K; Kroha, H; Kroll, J; Kroll, J; Kroseberg, J; Krstic, J; Kruchonak, U; Krüger, H; Krumnack, N; Kruse, M C; Kubota, T; Kucuk, H; Kuday, S; Kuechler, J T; Kuehn, S; Kugel, A; Kuger, F; Kuhl, T; Kukhtin, V; Kukla, R; Kulchitsky, Y; Kuleshov, S; Kulinich, Y P; Kuna, M; Kunigo, T; Kupco, A; Kupfer, T; Kuprash, O; Kurashige, H; Kurchaninov, L L; Kurochkin, Y A; Kurth, M G; Kus, V; Kuwertz, E S; Kuze, M; Kvita, J; Kwan, T; Kyriazopoulos, D; La Rosa, A; La Rosa Navarro, J L; La Rotonda, L; La Ruffa, F; Lacasta, C; Lacava, F; Lacey, J; Lacker, H; Lacour, D; Ladygin, E; Lafaye, R; Laforge, B; Lagouri, T; Lai, S; Lammers, S; Lampl, W; Lançon, E; Landgraf, U; Landon, M P J; Lanfermann, M C; Lang, V S; Lange, J C; Langenberg, R J; Lankford, A J; Lanni, F; Lantzsch, K; Lanza, A; Lapertosa, A; Laplace, S; Laporte, J F; Lari, T; Lasagni Manghi, F; Lassnig, M; Laurelli, P; Lavrijsen, W; Law, A T; Laycock, P; Lazovich, T; Lazzaroni, M; Le, B; Le Dortz, O; Le Guirriec, E; Le Quilleuc, E P; LeBlanc, M; LeCompte, T; Ledroit-Guillon, F; Lee, C A; Lee, G R; Lee, S C; Lee, L; Lefebvre, B; Lefebvre, G; Lefebvre, M; Legger, F; Leggett, C; Lehmann Miotto, G; Lei, X; Leight, W A; Leite, M A L; Leitner, R; Lellouch, D; Lemmer, B; Leney, K J C; Lenz, T; Lenzi, B; Leone, R; Leone, S; Leonidopoulos, C; Lerner, G; Leroy, C; Lesage, A A J; Lester, C G; Levchenko, M; Levêque, J; Levin, D; Levinson, L J; Levy, M; Lewis, D; Li, B; Li, Changqiao; Li, H; Li, L; Li, Q; Li, S; Li, X; Li, Y; Liang, Z; Liberti, B; Liblong, A; Lie, K; Liebal, J; Liebig, W; Limosani, A; Lin, S C; Lin, T H; Linck, R A; Lindquist, B E; Lionti, A E; Lipeles, E; Lipniacka, A; Lisovyi, M; Liss, T M; Lister, A; Litke, A M; Liu, B; Liu, H; Liu, H; Liu, J K K; Liu, J; Liu, J B; Liu, K; Liu, L; Liu, M; Liu, Y L; Liu, Y; Livan, M; Lleres, A; Llorente Merino, J; Lloyd, S L; Lo, C Y; Lo Sterzo, F; Lobodzinska, E M; Loch, P; Loebinger, F K; Loesle, A; Loew, K M; Loginov, A; Lohse, T; Lohwasser, K; Lokajicek, M; Long, B A; Long, J D; Long, R E; Longo, L; Looper, K A; Lopez, J A; Lopez Mateos, D; Lopez Paz, I; Lopez Solis, A; Lorenz, J; Lorenzo Martinez, N; Losada, M; Lösel, P J; Lou, X; Lounis, A; Love, J; Love, P A; Lu, H; Lu, N; Lu, Y J; Lubatti, H J; Luci, C; Lucotte, A; Luedtke, C; Luehring, F; Lukas, W; Luminari, L; Lundberg, O; Lund-Jensen, B; Lutz, M S; Luzi, P M; Lynn, D; Lysak, R; Lytken, E; Lyu, F; Lyubushkin, V; Ma, H; Ma, L L; Ma, Y; Maccarrone, G; Macchiolo, A; Macdonald, C M; Maček, B; Machado Miguens, J; Madaffari, D; Madar, R; Mader, W F; Madsen, A; Maeda, J; Maeland, S; Maeno, T; Maevskiy, A S; Magerl, V; Mahlstedt, J; Maiani, C; Maidantchik, C; Maier, A A; Maier, T; Maio, A; Majersky, O; Majewski, S; Makida, Y; Makovec, N; Malaescu, B; Malecki, Pa; Maleev, V P; Malek, F; Mallik, U; Malon, D; Malone, C; Maltezos, S; Malyukov, S; Mamuzic, J; Mancini, G; Mandić, I; Maneira, J; Manhaes de Andrade Filho, L; Manjarres Ramos, J; Mankinen, K H; Mann, A; Manousos, A; Mansoulie, B; Mansour, J D; Mantifel, R; Mantoani, M; Manzoni, S; Mapelli, L; Marceca, G; March, L; Marchese, L; Marchiori, G; Marcisovsky, M; Marjanovic, M; Marley, D E; Marroquim, F; Marsden, S P; Marshall, Z; Martensson, M U F; Marti-Garcia, S; Martin, C B; Martin, T A; Martin, V J; Martin Dit Latour, B; Martinez, M; Martinez Outschoorn, V I; Martin-Haugh, S; Martoiu, V S; Martyniuk, A C; Marzin, A; Masetti, L; Mashimo, T; Mashinistov, R; Masik, J; Maslennikov, A L; Massa, L; Mastrandrea, P; Mastroberardino, A; Masubuchi, T; Mättig, P; Maurer, J; Maxfield, S J; Maximov, D A; Mazini, R; Maznas, I; Mazza, S M; Mc Fadden, N C; Mc Goldrick, G; Mc Kee, S P; McCarn, A; McCarthy, R L; McCarthy, T G; McClymont, L I; McDonald, E F; Mcfayden, J A; Mchedlidze, G; McMahon, S J; McNamara, P C; McPherson, R A; Meehan, S; Megy, T J; Mehlhase, S; Mehta, A; Meideck, T; Meier, K; Meirose, B; Melini, D; Mellado Garcia, B R; Mellenthin, J D; Melo, M; Meloni, F; Melzer, A; Menary, S B; Meng, L; Meng, X T; Mengarelli, A; Menke, S; Meoni, E; Mergelmeyer, S; Mermod, P; Merola, L; Meroni, C; Merritt, F S; Messina, A; Metcalfe, J; Mete, A S; Meyer, C; Meyer, J-P; Meyer, J; Meyer Zu Theenhausen, H; Miano, F; Middleton, R P; Miglioranzi, S; Mijović, L; Mikenberg, G; Mikestikova, M; Mikuž, M; Milesi, M; Milic, A; Miller, D W; Mills, C; Milov, A; Milstead, D A; Minaenko, A A; Minami, Y; Minashvili, I A; Mincer, A I; Mindur, B; Mineev, M; Minegishi, Y; Ming, Y; Mir, L M; Mistry, K P; Mitani, T; Mitrevski, J; Mitsou, V A; Miucci, A; Miyagawa, P S; Mizukami, A; Mjörnmark, J U; Mkrtchyan, T; Mlynarikova, M; Moa, T; Mochizuki, K; Mogg, P; Mohapatra, S; Molander, S; Moles-Valls, R; Monden, R; Mondragon, M C; Mönig, K; Monk, J; Monnier, E; Montalbano, A; Montejo Berlingen, J; Monticelli, F; Monzani, S; Moore, R W; Morange, N; Moreno, D; Moreno Llácer, M; Morettini, P; Morgenstern, S; Mori, D; Mori, T; Morii, M; Morinaga, M; Morisbak, V; Morley, A K; Mornacchi, G; Morris, J D; Morvaj, L; Moschovakos, P; Mosidze, M; Moss, H J; Moss, J; Motohashi, K; Mount, R; Mountricha, E; Moyse, E J W; Muanza, S; Mueller, F; Mueller, J; Mueller, R S P; Muenstermann, D; Mullen, P; Mullier, G A; Munoz Sanchez, F J; Murray, W J; Musheghyan, H; Muškinja, M; Myagkov, A G; Myska, M; Nachman, B P; Nackenhorst, O; Nagai, K; Nagai, R; Nagano, K; Nagasaka, Y; Nagata, K; Nagel, M; Nagy, E; Nairz, A M; Nakahama, Y; Nakamura, K; Nakamura, T; Nakano, I; Naranjo Garcia, R F; Narayan, R; Narrias Villar, D I; Naryshkin, I; Naumann, T; Navarro, G; Nayyar, R; Neal, H A; Nechaeva, P Yu; Neep, T J; Negri, A; Negrini, M; Nektarijevic, S; Nellist, C; Nelson, A; Nelson, M E; Nemecek, S; Nemethy, P; Nessi, M; Neubauer, M S; Neumann, M; Newman, P R; Ng, T Y; Nguyen Manh, T; Nickerson, R B; Nicolaidou, R; Nielsen, J; Nikolaenko, V; Nikolic-Audit, I; Nikolopoulos, K; Nilsen, J K; Nilsson, P; Ninomiya, Y; Nisati, A; Nishu, N; Nisius, R; Nitsche, I; Nitta, T; Nobe, T; Noguchi, Y; Nomachi, M; Nomidis, I; Nomura, M A; Nooney, T; Nordberg, M; Norjoharuddeen, N; Novgorodova, O; Nowak, S; Nozaki, M; Nozka, L; Ntekas, K; Nurse, E; Nuti, F; O'connor, K; O'Neil, D C; O'Rourke, A A; O'Shea, V; Oakham, F G; Oberlack, H; Obermann, T; Ocariz, J; Ochi, A; Ochoa, I; Ochoa-Ricoux, J P; Oda, S; Odaka, S; Oh, A; Oh, S H; Ohm, C C; Ohman, H; Oide, H; Okawa, H; Okumura, Y; Okuyama, T; Olariu, A; Oleiro Seabra, L F; Olivares Pino, S A; Oliveira Damazio, D; Olszewski, A; Olszowska, J; Onofre, A; Onogi, K; Onyisi, P U E; Oppen, H; Oreglia, M J; Oren, Y; Orestano, D; Orlando, N; Orr, R S; Osculati, B; Ospanov, R; Otero Y Garzon, G; Otono, H; Ouchrif, M; Ould-Saada, F; Ouraou, A; Oussoren, K P; Ouyang, Q; Owen, M; Owen, R E; Ozcan, V E; Ozturk, N; Pachal, K; Pacheco Pages, A; Pacheco Rodriguez, L; Padilla Aranda, C; Pagan Griso, S; Paganini, M; Paige, F; Palacino, G; Palazzo, S; Palestini, S; Palka, M; Pallin, D; Panagiotopoulou, E St; Panagoulias, I; Pandini, C E; Panduro Vazquez, J G; Pani, P; Panitkin, S; Pantea, D; Paolozzi, L; Papadopoulou, Th D; Papageorgiou, K; Paramonov, A; Paredes Hernandez, D; Parker, A J; Parker, M A; Parker, K A; Parodi, F; Parsons, J A; Parzefall, U; Pascuzzi, V R; Pasner, J M; Pasqualucci, E; Passaggio, S; Pastore, Fr; Pataraia, S; Pater, J R; Pauly, T; Pearson, B; Pedraza Lopez, S; Pedro, R; Peleganchuk, S V; Penc, O; Peng, C; Peng, H; Penwell, J; Peralva, B S; Perego, M M; Perepelitsa, D V; Peri, F; Perini, L; Pernegger, H; Perrella, S; Peschke, R; Peshekhonov, V D; Peters, K; Peters, R F Y; Petersen, B A; Petersen, T C; Petit, E; Petridis, A; Petridou, C; Petroff, P; Petrolo, E; Petrov, M; Petrucci, F; Pettersson, N E; Peyaud, A; Pezoa, R; Phillips, F H; Phillips, P W; Piacquadio, G; Pianori, E; Picazio, A; Piccaro, E; Pickering, M A; Piegaia, R; Pilcher, J E; Pilkington, A D; Pin, A W J; Pinamonti, M; Pinfold, J L; Pirumov, H; Pitt, M; Plazak, L; Pleier, M-A; Pleskot, V; Plotnikova, E; Pluth, D; Podberezko, P; Poettgen, R; Poggi, R; Poggioli, L; Pohl, D; Polesello, G; Poley, A; Policicchio, A; Polifka, R; Polini, A; Pollard, C S; Polychronakos, V; Pommès, K; Ponomarenko, D; Pontecorvo, L; Popeneciu, G A; Portillo Quintero, D M; Pospisil, S; Potamianos, K; Potrap, I N; Potter, C J; Poulsen, T; Poveda, J; Pozo Astigarraga, M E; Pralavorio, P; Pranko, A; Prell, S; Price, D; Primavera, M; Prince, S; Proklova, N; Prokofiev, K; Prokoshin, F; Protopopescu, S; Proudfoot, J; Przybycien, M; Puri, A; Puzo, P; Qian, J; Qin, G; Qin, Y; Quadt, A; Queitsch-Maitland, M; Quilty, D; Raddum, S; Radeka, V; Radescu, V; Radhakrishnan, S K; Radloff, P; Rados, P; Ragusa, F; Rahal, G; Raine, J A; Rajagopalan, S; Rangel-Smith, C; Rashid, T; Raspopov, S; Ratti, M G; Rauch, D M; Rauscher, F; Rave, S; Ravinovich, I; Rawling, J H; Raymond, M; Read, A L; Readioff, N P; Reale, M; Rebuzzi, D M; Redelbach, A; Redlinger, G; Reece, R; Reed, R G; Reeves, K; Rehnisch, L; Reichert, J; Reiss, A; Rembser, C; Ren, H; Rescigno, M; Resconi, S; Resseguie, E D; Rettie, S; Reynolds, E; Rezanova, O L; Reznicek, P; Rezvani, R; Richter, R; Richter, S; Richter-Was, E; Ricken, O; Ridel, M; Rieck, P; Riegel, C J; Rieger, J; Rifki, O; Rijssenbeek, M; Rimoldi, A; Rimoldi, M; Rinaldi, L; Ripellino, G; Ristić, B; Ritsch, E; Riu, I; Rizatdinova, F; Rizvi, E; Rizzi, C; Roberts, R T; Robertson, S H; Robichaud-Veronneau, A; Robinson, D; Robinson, J E M; Robson, A; Rocco, E; Roda, C; Rodina, Y; Rodriguez Bosca, S; Rodriguez Perez, A; Rodriguez Rodriguez, D; Roe, S; Rogan, C S; Røhne, O; Roloff, J; Romaniouk, A; Romano, M; Romano Saez, S M; Romero Adam, E; Rompotis, N; Ronzani, M; Roos, L; Rosati, S; Rosbach, K; Rose, P; Rosien, N-A; Rossi, E; Rossi, L P; Rosten, J H N; Rosten, R; Rotaru, M; Rothberg, J; Rousseau, D; Rozanov, A; Rozen, Y; Ruan, X; Rubbo, F; Rühr, F; Ruiz-Martinez, A; Rurikova, Z; Rusakovich, N A; Russell, H L; Rutherfoord, J P; Ruthmann, N; Ryabov, Y F; Rybar, M; Rybkin, G; Ryu, S; Ryzhov, A; Rzehorz, G F; Saavedra, A F; Sabato, G; Sacerdoti, S; Sadrozinski, H F-W; Sadykov, R; Safai Tehrani, F; Saha, P; Sahinsoy, M; Saimpert, M; Saito, M; Saito, T; Sakamoto, H; Sakurai, Y; Salamanna, G; Salazar Loyola, J E; Salek, D; Sales De Bruin, P H; Salihagic, D; Salnikov, A; Salt, J; Salvatore, D; Salvatore, F; Salvucci, A; Salzburger, A; Sammel, D; Sampsonidis, D; Sampsonidou, D; Sánchez, J; Sanchez Martinez, V; Sanchez Pineda, A; Sandaker, H; Sandbach, R L; Sander, C O; Sandhoff, M; Sandoval, C; Sankey, D P C; Sannino, M; Sano, Y; Sansoni, A; Santoni, C; Santos, H; Santoyo Castillo, I; Sapronov, A; Saraiva, J G; Sarrazin, B; Sasaki, O; Sato, K; Sauvan, E; Savage, G; Savard, P; Savic, N; Sawyer, C; Sawyer, L; Saxon, J; Sbarra, C; Sbrizzi, A; Scanlon, T; Scannicchio, D A; Scarcella, M; Schaarschmidt, J; Schacht, P; Schachtner, B M; Schaefer, D; Schaefer, L; Schaefer, R; Schaeffer, J; Schaepe, S; Schaetzel, S; Schäfer, U; Schaffer, A C; Schaile, D; Schamberger, R D; Schegelsky, V A; Scheirich, D; Schernau, M; Schiavi, C; Schier, S; Schildgen, L K; Schillo, C; Schioppa, M; Schlenker, S; Schmidt-Sommerfeld, K R; Schmieden, K; Schmitt, C; Schmitt, S; Schmitz, S; Schnoor, U; Schoeffel, L; Schoening, A; Schoenrock, B D; Schopf, E; Schott, M; Schouwenberg, J F P; Schovancova, J; Schramm, S; Schuh, N; Schulte, A; Schultens, M J; Schultz-Coulon, H-C; Schulz, H; Schumacher, M; Schumm, B A; Schune, Ph; Schwartzman, A; Schwarz, T A; Schweiger, H; Schwemling, Ph; Schwienhorst, R; Schwindling, J; Sciandra, A; Sciolla, G; Scornajenghi, M; Scuri, F; Scutti, F; Searcy, J; Seema, P; Seidel, S C; Seiden, A; Seixas, J M; Sekhniaidze, G; Sekhon, K; Sekula, S J; Semprini-Cesari, N; Senkin, S; Serfon, C; Serin, L; Serkin, L; Sessa, M; Seuster, R; Severini, H; Sfiligoj, T; Sforza, F; Sfyrla, A; Shabalina, E; Shaikh, N W; Shan, L Y; Shang, R; Shank, J T; Shapiro, M; Shatalov, P B; Shaw, K; Shaw, S M; Shcherbakova, A; Shehu, C Y; Shen, Y; Sherafati, N; Sherwood, P; Shi, L; Shimizu, S; Shimmin, C O; Shimojima, M; Shipsey, I P J; Shirabe, S; Shiyakova, M; Shlomi, J; Shmeleva, A; Shoaleh Saadi, D; Shochet, M J; Shojaii, S; Shope, D R; Shrestha, S; Shulga, E; Shupe, M A; Sicho, P; Sickles, A M; Sidebo, P E; Sideras Haddad, E; Sidiropoulou, O; Sidoti, A; Siegert, F; Sijacki, Dj; Silva, J; Silverstein, S B; Simak, V; Simic, Lj; Simion, S; Simioni, E; Simmons, B; Simon, M; Sinervo, P; Sinev, N B; Sioli, M; Siragusa, G; Siral, I; Sivoklokov, S Yu; Sjölin, J; Skinner, M B; Skubic, P; Slater, M; Slavicek, T; Slawinska, M; Sliwa, K; Slovak, R; Smakhtin, V; Smart, B H; Smiesko, J; Smirnov, N; Smirnov, S Yu; Smirnov, Y; Smirnova, L N; Smirnova, O; Smith, J W; Smith, M N K; Smith, R W; Smizanska, M; Smolek, K; Snesarev, A A; Snyder, I M; Snyder, S; Sobie, R; Socher, F; Soffer, A; Søgaard, A; Soh, D A; Sokhrannyi, G; Solans Sanchez, C A; Solar, M; Soldatov, E Yu; Soldevila, U; Solodkov, A A; Soloshenko, A; Solovyanov, O V; Solovyev, V; Sommer, P; Son, H; Sopczak, A; Sosa, D; Sotiropoulou, C L; Soualah, R; Soukharev, A M; South, D; Sowden, B C; Spagnolo, S; Spalla, M; Spangenberg, M; Spanò, F; Sperlich, D; Spettel, F; Spieker, T M; Spighi, R; Spigo, G; Spiller, L A; Spousta, M; St Denis, R D; Stabile, A; Stamen, R; Stamm, S; Stanecka, E; Stanek, R W; Stanescu, C; Stanitzki, M M; Stapf, B S; Stapnes, S; Starchenko, E A; Stark, G H; Stark, J; Stark, S H; Staroba, P; Starovoitov, P; Stärz, S; Staszewski, R; Steinberg, P; Stelzer, B; Stelzer, H J; Stelzer-Chilton, O; Stenzel, H; Stewart, G A; Stockton, M C; Stoebe, M; Stoicea, G; Stolte, P; Stonjek, S; Stradling, A R; Straessner, A; Stramaglia, M E; Strandberg, J; Strandberg, S; Strauss, M; Strizenec, P; Ströhmer, R; Strom, D M; Stroynowski, R; Strubig, A; Stucci, S A; Stugu, B; Styles, N A; Su, D; Su, J; Suchek, S; Sugaya, Y; Suk, M; Sulin, V V; Sultan, Dms; Sultansoy, S; Sumida, T; Sun, S; Sun, X; Suruliz, K; Suster, C J E; Sutton, M R; Suzuki, S; Svatos, M; Swiatlowski, M; Swift, S P; Sykora, I; Sykora, T; Ta, D; Tackmann, K; Taenzer, J; Taffard, A; Tafirout, R; Tahirovic, E; Taiblum, N; Takai, H; Takashima, R; Takasugi, E H; Takeshita, T; Takubo, Y; Talby, M; Talyshev, A A; Tanaka, J; Tanaka, M; Tanaka, R; Tanaka, S; Tanioka, R; Tannenwald, B B; Tapia Araya, S; Tapprogge, S; Tarem, S; Tartarelli, G F; Tas, P; Tasevsky, M; Tashiro, T; Tassi, E; Tavares Delgado, A; Tayalati, Y; Taylor, A C; Taylor, G N; Taylor, P T E; Taylor, W; Teixeira-Dias, P; Temple, D; Ten Kate, H; Teng, P K; Teoh, J J; Tepel, F; Terada, S; Terashi, K; Terron, J; Terzo, S; Testa, M; Teuscher, R J; Theveneaux-Pelzer, T; Thiele, F; Thomas, J P; Thomas-Wilsker, J; Thompson, P D; Thompson, A S; Thomsen, L A; Thomson, E; Tibbetts, M J; Ticse Torres, R E; Tikhomirov, V O; Tikhonov, Yu A; Timoshenko, S; Tipton, P; Tisserant, S; Todome, K; Todorova-Nova, S; Todt, S; Tojo, J; Tokár, S; Tokushuku, K; Tolley, E; Tomlinson, L; Tomoto, M; Tompkins, L; Toms, K; Tong, B; Tornambe, P; Torrence, E; Torres, H; Torró Pastor, E; Toth, J; Touchard, F; Tovey, D R; Treado, C J; Trefzger, T; Tresoldi, F; Tricoli, A; Trigger, I M; Trincaz-Duvoid, S; Tripiana, M F; Trischuk, W; Trocmé, B; Trofymov, A; Troncon, C; Trottier-McDonald, M; Trovatelli, M; Truong, L; Trzebinski, M; Trzupek, A; Tsang, K W; Tseng, J C-L; Tsiareshka, P V; Tsipolitis, G; Tsirintanis, N; Tsiskaridze, S; Tsiskaridze, V; Tskhadadze, E G; Tsui, K M; Tsukerman, I I; Tsulaia, V; Tsuno, S; Tsybychev, D; Tu, Y; Tudorache, A; Tudorache, V; Tulbure, T T; Tuna, A N; Tupputi, S A; Turchikhin, S; Turgeman, D; Turk Cakir, I; Turra, R; Tuts, P M; Ucchielli, G; Ueda, I; Ughetto, M; Ukegawa, F; Unal, G; Undrus, A; Unel, G; Ungaro, F C; Unno, Y; Unverdorben, C; Urban, J; Urquijo, P; Urrejola, P; Usai, G; Usui, J; Vacavant, L; Vacek, V; Vachon, B; Vadla, K O H; Vaidya, A; Valderanis, C; Valdes Santurio, E; Valente, M; Valentinetti, S; Valero, A; Valéry, L; Valkar, S; Vallier, A; Valls Ferrer, J A; Van Den Wollenberg, W; van der Graaf, H; van Gemmeren, P; Van Nieuwkoop, J; van Vulpen, I; van Woerden, M C; Vanadia, M; Vandelli, W; Vaniachine, A; Vankov, P; Vardanyan, G; Vari, R; Varnes, E W; Varni, C; Varol, T; Varouchas, D; Vartapetian, A; Varvell, K E; Vasquez, J G; Vasquez, G A; Vazeille, F; Vazquez Schroeder, T; Veatch, J; Veeraraghavan, V; Veloce, L M; Veloso, F; Veneziano, S; Ventura, A; Venturi, M; Venturi, N; Venturini, A; Vercesi, V; Verducci, M; Verkerke, W; Vermeulen, A T; Vermeulen, J C; Vetterli, M C; Viaux Maira, N; Viazlo, O; Vichou, I; Vickey, T; Vickey Boeriu, O E; Viehhauser, G H A; Viel, S; Vigani, L; Villa, M; Villaplana Perez, M; Vilucchi, E; Vincter, M G; Vinogradov, V B; Vishwakarma, A; Vittori, C; Vivarelli, I; Vlachos, S; Vogel, M; Vokac, P; Volpi, G; von der Schmitt, H; von Toerne, E; Vorobel, V; Vorobev, K; Vos, M; Voss, R; Vossebeld, J H; Vranjes, N; Vranjes Milosavljevic, M; Vrba, V; Vreeswijk, M; Vuillermet, R; Vukotic, I; Wagner, P; Wagner, W; Wagner-Kuhr, J; Wahlberg, H; Wahrmund, S; Wakabayashi, J; Walder, J; Walker, R; Walkowiak, W; Wallangen, V; Wang, C; Wang, C; Wang, F; Wang, H; Wang, H; Wang, J; Wang, J; Wang, Q; Wang, R; Wang, S M; Wang, T; Wang, W; Wang, W; Wang, Z; Wanotayaroj, C; Warburton, A; Ward, C P; Wardrope, D R; Washbrook, A; Watkins, P M; Watson, A T; Watson, M F; Watts, G; Watts, S; Waugh, B M; Webb, A F; Webb, S; Weber, M S; Weber, S W; Weber, S A; Webster, J S; Weidberg, A R; Weinert, B; Weingarten, J; Weirich, M; Weiser, C; Weits, H; Wells, P S; Wenaus, T; Wengler, T; Wenig, S; Wermes, N; Werner, M D; Werner, P; Wessels, M; Weston, T D; Whalen, K; Whallon, N L; Wharton, A M; White, A S; White, A; White, M J; White, R; Whiteson, D; Whitmore, B W; Wickens, F J; Wiedenmann, W; Wielers, M; Wiglesworth, C; Wiik-Fuchs, L A M; Wildauer, A; Wilk, F; Wilkens, H G; Williams, H H; Williams, S; Willis, C; Willocq, S; Wilson, J A; Wingerter-Seez, I; Winkels, E; Winklmeier, F; Winston, O J; Winter, B T; Wittgen, M; Wobisch, M; Wolf, T M H; Wolff, R; Wolter, M W; Wolters, H; Wong, V W S; Worm, S D; Wosiek, B K; Wotschack, J; Wozniak, K W; Wu, M; Wu, S L; Wu, X; Wu, Y; Wyatt, T R; Wynne, B M; Xella, S; Xi, Z; Xia, L; Xu, D; Xu, L; Xu, T; Yabsley, B; Yacoob, S; Yamaguchi, D; Yamaguchi, Y; Yamamoto, A; Yamamoto, S; Yamanaka, T; Yamatani, M; Yamauchi, K; Yamazaki, Y; Yan, Z; Yang, H; Yang, H; Yang, Y; Yang, Z; Yao, W-M; Yap, Y C; Yasu, Y; Yatsenko, E; Yau Wong, K H; Ye, J; Ye, S; Yeletskikh, I; Yigitbasi, E; Yildirim, E; Yorita, K; Yoshihara, K; Young, C; Young, C J S; Yu, J; Yu, J; Yuen, S P Y; Yusuff, I; Zabinski, B; Zacharis, G; Zaidan, R; Zaitsev, A M; Zakharchuk, N; Zalieckas, J; Zaman, A; Zambito, S; Zanzi, D; Zeitnitz, C; Zemaityte, G; Zemla, A; Zeng, J C; Zeng, Q; Zenin, O; Ženiš, T; Zerwas, D; Zhang, D; Zhang, F; Zhang, G; Zhang, H; Zhang, J; Zhang, L; Zhang, L; Zhang, M; Zhang, P; Zhang, R; Zhang, R; Zhang, X; Zhang, Y; Zhang, Z; Zhao, X; Zhao, Y; Zhao, Z; Zhemchugov, A; Zhou, B; Zhou, C; Zhou, L; Zhou, M; Zhou, M; Zhou, N; Zhu, C G; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zibell, A; Zieminska, D; Zimine, N I; Zimmermann, C; Zimmermann, S; Zinonos, Z; Zinser, M; Ziolkowski, M; Živković, L; Zobernig, G; Zoccoli, A; Zou, R; Zur Nedden, M; Zwalinski, L

2017-11-03

Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a bb[over ¯] pair with the ATLAS detector using 36.1  fb^{-1} of pp collisions at a center-of-mass energy of 13 TeV at the LHC. The observed data are in agreement with the standard model predictions and limits are placed on the associated production of dark-matter particles and a Higgs boson.

Cardiac Autonomic Neuropathy May Play a Role in Pathogenesis of Atherosclerosis in Type 1 Diabetes Mellitus

Czech Academy of Sciences Publication Activity Database

Malá, Š.; Potočková, V.; Hoskovcová, L.; Pithová, P.; Brabec, Marek; Kulhánková, J.; Keil, R.; Riedlbauchová, L.; Brož, J.

2017-01-01

Roč. 134, December (2017), s. 139-144 ISSN 0168-8227 Institutional support: RVO:67985807 Keywords : autonomic neuropathy * diabetes mellitus * intima media thickness * atherosclerosis * heart rate variability Subject RIV: BB - Applied Statistics, Operational Research OBOR OECD: Statistics and probability Impact factor: 3.639, year: 2016

Search for the standard model Higgs boson decaying to a bb pair in events with one charged lepton and large missing transverse energy using the full CDF data set.

Science.gov (United States)

Aaltonen, T; Álvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Bae, T; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M E; Bisello, D; Bizjak, I; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brigliadori, L; Bromberg, C; Brucken, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Calamba, A; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chung, W H; Chung, Y S; Ciocci, M A; Clark, A; Clarke, C; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuevas, J; Culbertson, R; Dagenhart, D; d'Ascenzo, N; Datta, M; de Barbaro, P; Dell'Orso, M; Demortier, L; Deninno, M; Devoto, F; d'Errico, M; Di Canto, A; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, M; Dorigo, T; Ebina, K; Elagin, A; Eppig, A; Erbacher, R; Errede, S; Ershaidat, N; Eusebi, R; Farrington, S; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Funakoshi, Y; Furic, I; Gallinaro, M; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldin, D; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Grinstein, S; Grosso-Pilcher, C; Group, R C; Guimaraes da Costa, J; Hahn, S R; Halkiadakis, E; Hamaguchi, A; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Hewamanage, S; Hocker, A; Hopkins, W; Horn, D; Hou, S; Hughes, R E; Hurwitz, M; Husemann, U; Hussain, N; Hussein, M; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeans, D T; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kim, Y J; Kimura, N; Kirby, M; Klimenko, S; Knoepfel, K; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Kruse, M; Krutelyov, V; Kuhr, T; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; LeCompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leo, S; Leone, S; Lewis, J D; Limosani, A; Lin, C-J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, H; Liu, Q; Liu, T; Lockwitz, S; Loginov, A; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Madrak, R; Maeshima, K; Maestro, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Martínez, M; Mastrandrea, P; Matera, K; Mattson, M E; Mazzacane, A; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Noh, S Y; Norniella, O; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Poprocki, S; Potamianos, K; Prokoshin, F; Pranko, A; Ptohos, F; Punzi, G; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Rescigno, M; Riddick, T; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Safonov, A; Sakumoto, W K; Sakurai, Y; Santi, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shochet, M; Shreyber-Tecker, I; Simonenko, A; Sinervo, P; Sliwa, K; Smith, J R; Snider, F D; Soha, A; Sorin, V; Song, H; Squillacioti, P; Stancari, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Ukegawa, F; Uozumi, S; Varganov, A; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vizán, J; Vogel, M; Volpi, G; Wagner, P; Wagner, R L; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Wester, W C; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Wick, F; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamato, D; Yang, T; Yang, U K; Yang, Y C; Yao, W-M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhou, C; Zucchelli, S

2012-09-14

We present a search for the standard model Higgs boson produced in association with a W boson in sqrt[s]=1.96  TeV pp collision data collected with the CDF II detector at the Tevatron corresponding to an integrated luminosity of 9.45  fb(-1). In events consistent with the decay of the Higgs boson to a bottom-quark pair and the W boson to an electron or muon and a neutrino, we set 95% credibility level upper limits on the WH production cross section times the H→bb branching ratio as a function of Higgs boson mass. At a Higgs boson mass of 125  GeV/c(2), we observe (expect) a limit of 4.9 (2.8) times the standard model value.

Origin of very-short orbital-period binary systems

International Nuclear Information System (INIS)

Miyaji, S.

1983-01-01

Recent observations of four close binaries have established that there is a group of very-short orbital-period (VSOP) binaries whose orbital periods are less than 60 minutes. The VSOP binaries consist of both X-ray close binaries and cataclysmic variables. Their orbital periods are too short to have a main-sequence companion. However, four binaries, none of which belongs to any globular cluster, are too abundant to be explained by the capturing mechanism of a white dwarf. Therefore it seemed to be worthwhile to present an evolutionary scenario from an original binary system which can be applied for all VSOP binaries. (Auth.)

Is Green Regulation Effective or a Failure: Comparative Analysis between Bangladesh Bank (BB Green Guidelines and Global Reporting Initiative Guidelines

Directory of Open Access Journals (Sweden)

Md. Abdul Kaium Masud

2018-04-01

Full Text Available Green reporting and green regulation have been commonly used in the sustainability movement. This study evaluates Bangladesh Bank’s (BB’s green regulation by considering the global reporting initiative (GRI of environmental regulation along with self-determined content to justify BB’s institutional effort in the banking sector. The analytical study has considered secondary data of all listed banks on the Dhaka Stock Exchange between 2013 to 2016. A multi-theoretical framework has been adopted in which the research is comprised of institutional, stakeholder, and legitimacy theories. Considering the analytical research, we have drawn-up a green reporting score and undertaken SWOT analysis. The results of the study have identified the narrow coverage of BB’s regulation and strategic limitations. Moreover, the findings of the study show that banking companies disclosed more green information in line with BB’s regulation. Furthermore, our analysis has found the lack of transparency of green reporting in terms of absent global reporting as well as external verification. Additionally, we have documented that BB’s regulation falls into a legitimacy threat owing to political, corporate, and social responsibility. Therefore, we concluded that for BB to overcome all possible weaknesses and threats, it should consider all possible opportunities for a holistic international reporting framework while taking into account a transparent financial sector.

Complete mitochondrial genome sequence of black mustard (Brassica nigra; BB) and comparison with Brassica oleracea (CC) and Brassica carinata (BBCC).

Science.gov (United States)

Yamagishi, Hiroshi; Tanaka, Yoshiyuki; Terachi, Toru

2014-11-01

Crop species of Brassica (Brassicaceae) consist of three monogenomic species and three amphidiploid species resulting from interspecific hybridizations among them. Until now, mitochondrial genome sequences were available for only five of these species. We sequenced the mitochondrial genome of the sixth species, Brassica nigra (nuclear genome constitution BB), and compared it with those of Brassica oleracea (CC) and Brassica carinata (BBCC). The genome was assembled into a 232 145 bp circular sequence that is slightly larger than that of B. oleracea (219 952 bp). The genome of B. nigra contained 33 protein-coding genes, 3 rRNA genes, and 17 tRNA genes. The cox2-2 gene present in B. oleracea was absent in B. nigra. Although the nucleotide sequences of 52 genes were identical between B. nigra and B. carinata, the second exon of rps3 showed differences including an insertion/deletion (indel) and nucleotide substitutions. A PCR test to detect the indel revealed intraspecific variation in rps3, and in one line of B. nigra it amplified a DNA fragment of the size expected for B. carinata. In addition, the B. carinata lines tested here produced DNA fragments of the size expected for B. nigra. The results indicate that at least two mitotypes of B. nigra were present in the maternal parents of B. carinata.

Layered Atlantic Smoke Interactions with Clouds (LASIC) Science Plan

Energy Technology Data Exchange (ETDEWEB)

Zuidema, P [University of Miami; Chiu, C [University of Reading; Fairall, CW [NOAA - Environmental Technology Laboratory; Ghan, SJ [Pacific Northwest National Laboratory; Kollias, P [Stony Brook University; McFarguhar, GM; Mechem, DB [University of Kansas; Romps, DM [Lawrence Berkeley National Laboratory; Wong, H; Yuter, SE [North Carolina State University; Alvarado, MJ [Atmospheric and Environmental Research, Inc.; DeSzoeke, SP; Feingold, G [NOAA - Earth System Research Laboratory; Haywood, JM; Lewis, ER [Brookhaven National Laboratory; McComiskey, A [National Oceanic and Atmospheric Administration; Redemann, J [NASA - Ames Research Center; Turner, DD [National Oceanic and Atmospheric Administration; Wood, R [University of Washington; Zhu, P [Florida International University

2015-12-01

Southern Africa is the world’s largest emitter of biomass-burning (BB) aerosols. Their westward transport over the remote southeast Atlantic Ocean colocates some of the largest atmospheric loadings of absorbing aerosol with the least examined of the Earth’s major subtropical stratocumulus decks. Global aerosol model results highlight that the largest positive top-of-atmosphere forcing in the world occurs in the southeast Atlantic, but this region exhibits large differences in magnitude and sign between reputable models, in part because of high variability in the underlying model cloud distributions. Many uncertainties contribute to the highly variable model radiation fields: the aging of shortwave-absorbing aerosol during transport, how much of the aerosol mixes into the cloudy boundary layer, and how the low clouds adjust to smoke-radiation and smoke-cloud interactions. In addition, the ability of the BB aerosol to absorb shortwave radiation is known to vary seasonally as the fuel type on land changes.

Salivary mutans streptococci and lactobacilli modulations in young children on consumption of probiotic ice-cream containing Bifidobacterium lactis Bb12 and Lactobacillus acidophilus La5.

Science.gov (United States)

Singh, Richa Polka; Damle, Satyawan Gangaram; Chawla, Amrita

2011-11-01

To compare the levels of mutans streptococci and lactobacilli in saliva of school children, before and after consumption of probiotic and control ice-cream. A double-blind, cross-over, placebo-controlled trial was carried out in forty, 12-14 year-old children, with no clinically detectable caries. The selected children were randomized equally into two groups I and II. Following an initial run-in period of 1 week, children in group I and II were given ice-creams 'A' and 'B', respectively, for 10 days. Being a cross-over study, the ice-creams were interchanged in the two groups after a 2-week wash-out period. Saliva samples at baseline and follow-up were assessed using Dentocult SM and Dentocult LB kits. On statistical evaluation, it was seen that probiotic ice-cream brought about a statistically significant reduction (p-value = 0.003) in salivary mutans streptococci levels with no significant effect on lactobacilli levels. In conclusion, probiotic ice-cream containing Bifidobacterium lactis Bb-12 ATCC27536 and Lactobacillus acidophilus La-5 can reduce the levels of certain caries-associated micro-organisms in saliva.

Deletion of the B-B' and C-C' regions of inverted terminal repeats reduces rAAV productivity but increases transgene expression.

Science.gov (United States)

Zhou, Qingzhang; Tian, Wenhong; Liu, Chunguo; Lian, Zhonghui; Dong, Xiaoyan; Wu, Xiaobing

2017-07-14

Inverted terminal repeats (ITRs) of the adeno-associated virus (AAV) are essential for rescue, replication, packaging, and integration of the viral genome. While ITR mutations have been identified in previous reports, we designed a new truncated ITR lacking the B-B' and C-C' regions named as ITRΔBC and investigated its effects on viral genome replication, packaging, and expression of recombinant AAV (rAAV). The packaging ability was compared between ITRΔBC rAAV and wild-type (wt) ITR rAAV. Our results showed the productivity of ITRΔBC rAAV was reduced 4-fold, which is consistent with the 8-fold decrease in the replication of viral genomic DNA of ITRΔBC rAAV compared with wt ITR rAAV. Surprisingly, transgene expression was significantly higher for ITRΔBC rAAV. A preliminary exploration of the underlying mechanisms was carried out by inhibiting and degrading the ataxia telangiectasia mutated (ATM) protein and the Mre11 complex (MRN), respectively, since the rAAV expression was inhibited by the ATM and/or MRN through cis interaction or binding with wt ITRs. We demonstrated that the inhibitory effects were weakened on ITRΔBC rAAV expression. This study suggests deletion in ITR can affect the transgene expression of AAV, which provides a new way to improve the AAV expression through ITRs modification.

Growth/differentiation factor-5 significantly enhances periodontal wound healing/regeneration compared with platelet-derived growth factor-BB in dogs.

Science.gov (United States)

Kwon, Hyuk-Rak; Wikesjö, Ulf M E; Park, Jung-Chul; Kim, Young-Taek; Bastone, Patrizia; Pippig, Susanne D; Kim, Chong-Kwan

2010-08-01

Recombinant human growth/differentiation factor-5 (rhGDF-5) in a particulate beta-tricalcium phosphate (beta-TCP) carrier is being evaluated to support periodontal regeneration. The objective of this study was to evaluate periodontal wound healing/regeneration following an established clinical (benchmark) protocol including surgical implantation of rhGDF-5/beta-TCP in comparison with that following implantation of recombinant human platelet-derived growth factor-BB (rhPDGF) combined with a particulate beta-TCP biomaterial using an established canine defect model. Bilateral, 4 x 5 mm (width x depth), one-wall, critical-size, intrabony periodontal defects were surgically created at the mandibular second and fourth pre-molar teeth in five adult Beagle dogs. Defect sites were randomized to receive rhGDF-5/beta-TCP or the rhPDGF construct followed by wound closure for primary intention healing. The animals were sacrificed following an 8-week healing interval for histological and histometric examination. Clinical healing was generally uneventful. Sites receiving rhGDF-5/beta-TCP exhibited a significantly enhanced cementum formation compared with sites receiving the rhPDGF construct, averaging (+/-SD) 4.49+/-0.48 versus 2.72+/-0.91 mm (palveolar bone. Both protocols displayed beta-TCP residues apparently undergoing resorption. Application of both materials appears safe, as they were associated with limited, if any, adverse events. rhGDF-5/beta-TCP shows a significant potential to support/accelerate periodontal wound healing/regeneration. Application of rhGDF-5/beta-TCP appears safe and should be further evaluated in human clinical trials.

High-speed photometry of Gaia14aae: an eclipsing AM CVn that challenges formation models

Science.gov (United States)

Green, M. J.; Marsh, T. R.; Steeghs, D. T. H.; Kupfer, T.; Ashley, R. P.; Bloemen, S.; Breedt, E.; Campbell, H. C.; Chakpor, A.; Copperwheat, C. M.; Dhillon, V. S.; Hallinan, G.; Hardy, L. K.; Hermes, J. J.; Kerry, P.; Littlefair, S. P.; Milburn, J.; Parsons, S. G.; Prasert, N.; van Roestel, J.; Sahman, D. I.; Singh, N.

2018-05-01

AM CVn-type systems are ultracompact, hydrogen-deficient accreting binaries with degenerate or semidegenerate donors. The evolutionary history of these systems can be explored by constraining the properties of their donor stars. We present high-speed photometry of Gaia14aae, an AM CVn with a binary period of 49. 7 min and the first AM CVn in which the central white dwarf is fully eclipsed by the donor star. Modelling of the light curves of this system allows for the most precise measurement to date of the donor mass of an AM CVn, and relies only on geometric and well-tested physical assumptions. We find a mass ratio q = M2/M1 = 0.0287 ± 0.0020 and masses M1 = 0.87 ± 0.02 M⊙ and M2 = 0.0250 ± 0.0013 M⊙. We compare these properties to the three proposed channels for AM CVn formation. Our measured donor mass and radius do not fit with the contraction that is predicted for AM CVn donors descended from white dwarfs or helium stars at long orbital periods. The donor properties we measure fall in a region of parameter space in which systems evolved from hydrogen-dominated cataclysmic variables are expected, but such systems should show spectroscopic hydrogen, which is not seen in Gaia14aae. The evolutionary history of this system is therefore not clear. We consider a helium-burning star or an evolved cataclysmic variable to be the most likely progenitors, but both models require additional processes and/or fine-tuning to fit the data. Additionally, we calculate an updated ephemeris which corrects for an anomalous time measurement in the previously published ephemeris.

Immunization with a dicistronic plasmid expressing a truncated form of bovine herpesvirus-1 glycoprotein D and the amino-terminal subunit of glycoprotein B results in reduced gB-specific immune responses

International Nuclear Information System (INIS)

Manoj, Sharmila; Babiuk, Lorne A.; Drunen Littel van-Hurk, Sylvia van den

2003-01-01

As an approach to create a divalent DNA vaccine, a truncated secreted version of bovine herpesvirus-1 (BHV-1) glycoprotein D (tgD) and the amino-terminal subunit of glycoprotein B (gBb) were expressed from a dicistronic plasmid, designated pSLIAtgD-IRES-gBb. Intradermal immunization of mice with pSLIAtgD-IRES-gBb or a mixture of plasmids encoding tgD (pSLIAtgD) and gBb (pSLIAgBb) by needle injection or gene gun elicited strong tgD-specific immune responses. However, a significant reduction in gBb-specific immune responses was observed upon immunization of mice with pSLIAtgD-IRES-gBb or a mixture of pSLIAtgD and pSLIAgBb in comparison to immunization with pSLIAgBb alone. This reduction in gBb-specific immune responses induced by pSLIAtgD-IRES-gBb was due to production of low amounts of gBb from pSLIAtgD-IRES-gBb, inefficient processing and transport of gBb, and possibly competition for antigen-presenting cells by tgD and gBb. These results indicate that, although divalent plasmids may be used to express different antigens, the efficacy of vaccination with such plasmids may be influenced by the plasmid design and the characteristics of the expressed antigens

Seasonal and regional differentiation of bio-optical properties within the north polar Atlantic

Science.gov (United States)

Stramska, Malgorzata; Stramski, Dariusz; Kaczmarek, SłAwomir; Allison, David B.; Schwarz, Jill

2006-08-01

Using field data from the north polar Atlantic, we examined seasonal variability of the spectral absorption, a(λ), and backscattering, bb(λ), coefficients of surface waters in relation to phytoplankton pigments. For a given chlorophyll a concentration, the concentrations of accessory pigments were lower in spring than in summer. This effect contributed to lower chlorophyll-specific absorption of phytoplankton and total particulate matter in spring. The spring values of the green-to-blue band ratio of a(λ) were higher than the summer ratios. The blue-to-green ratios of bb(λ) were also higher in spring. The higher bb values and lower blue-to-green bb ratios in summer were likely associated with higher concentrations of detrital particles in summer compared to spring. Because the product of these band ratios of a and bb is a proxy for the blue-to-green ratio of remote-sensing reflectance, the performance of ocean color band-ratio algorithms for estimating pigments is significantly affected by seasonal shifts in the relationships between absorption, backscattering, and chlorophyll a. Our results suggest that the algorithm for the spring season would predict chlorophyll a that is higher by as much as a factor of 4-6 compared to that predicted from the summer algorithm. This indicates a need for a seasonal approach in the north polar Atlantic. However, we also found that a fairly good estimate of the particulate beam attenuation coefficient at 660 nm (a proxy for total particulate matter or particulate organic carbon concentration) can be obtained by applying a single blue-to-green band-ratio algorithm regardless of the season.

IPHAS J025827.88+635234.9 and IPHAS J051814.33+294113.0: Two probable eclipsing intermediate polars

Science.gov (United States)

Joshi, Arti; Pandey, Jeewan Chandra

2018-04-01

We present photometry in the R-band and linear polarimetry of two cataclysmic variables, namely IPHAS J025827.88 + 635234.9 and IPHAS J051814.33 + 294113.0. The data were obtained from 1-m class tele-scopes of the Aryabhatta Research Institute of Observational Sciences (ARIES; Nainital, India). In addition to the deep eclipse, strong short-period oscillations are also found. We derived a pulse period of (1203 ± 25) s for IPHAS J025827.88 + 635234.9 and (3277 ± 81) s for IPHAS J051814.33 + 294113.0. The presence of both orbital and spin modulations in these systems indicate that they belong to a class of intermediate polars. The full width at half depth of the eclipse is also found to be variable from epoch to epoch for IPHAS J025827.88 + 635234.9. The presence of a variable linear polarization of high value in these two sources indicates that these systems possess a strong magnetic field.

CCD Photometry Using Multiple Comparison Stars

Directory of Open Access Journals (Sweden)

Yonggi Kim

2004-09-01

Full Text Available The accuracy of CCD observations obtained at the Korean 1.8 m telescope has been studied. Seventeen comparison stars in the vicinity of the cataclysmic variable BG CMi have been measured. The ``artificial" star has been used instead of the ``control" star, what made possible to increase accuracy estimates by a factor of 1.3-2.1 times for ``good" and ``cloudy" nights, respectively. The algorithm of iterative determination of accuracy and weights of few comparison stars contributing to the artificial star, has been presented. The accuracy estimates for 13-mag stars are around 0.002 m mag for exposure times of 30 sec.

OV Bootis: Forty Nights of World-Wide Photometry (Abstract)

Science.gov (United States)

Patterson, J.; de Miguel, E.; Barret, D.; Brincat, S.; Boardman, J., Jr.; Buczynski, D.; Campbell, T.; Cejudo, D.; Cook, L.; Cook, M. J.; Collins, D.; Cooney, W.; Dubois, F.; Dvorak, S.; Halpern, J. P.; Kroes, A. J.; Lemay, D.; Licchelli, D.; Mankel, D.; Marshall, M.; Novak, R.; Oksanen, A.; Roberts, G.; Seargeant, J.; Sears, H.; Silcox, A.; Slauson, D.; Stone, G.; Thorstensen, J. R.; Ulowetz, J.; Vanmunster, T.; Wallgren, J.; Wood, M.

2017-12-01

(Abstract only) Among the 1000 known cataclysmic variables, only one appears to belong to the "Galactic halo"-the Population II stars. We report round-the-world photometry of this star (OV Boo) during March-April 2017, when it staged its first certified dwarf-nova outburst. The star is remarkable for its short binary period (66 minutes), high proper motion, metal-poor composition, substellar secondary, sharp white-dwarf eclipses, and nonradial pulsations. Something for everybody - and it even had the good manners to erupt in northern springtime, when it transits near local midnight. Move over, SS Cyg and WZ Sge; there's a new celebrity in town!

How to Model Super-Soft X-ray Sources?

Science.gov (United States)

Rauch, Thomas

2012-07-01

During outbursts, the surface temperatures of white dwarfs in cataclysmic variables exceed by far half a million Kelvin. In this phase, they may become the brightest super-soft sources (SSS) in the sky. Time-series of high-resolution, high S/N X-ray spectra taken during rise, maximum, and decline of their X-ray luminosity provide insights into the processes following such outbursts as well as in the surface composition of the white dwarf. Their analysis requires adequate NLTE model atmospheres. The Tuebingen Non-LTE Model-Atmosphere Package (TMAP) is a powerful tool for their calculation. We present the application of TMAP models to SSS spectra and discuss their validity.

QPOs in CVs: An executive summary

Science.gov (United States)

Warner, Brian; Woudt, Patrick A.

2008-09-01

An overview is given of the properties of the various kinds of quasi-periodic luminosity modulations observed in cataclysmic variables (CVs). The two principal types, known in the CV literature as dwarf nova oscillations and quasi-periodic oscillations, have similarities to the high and low frequency quasi-periodic oscillations in X-Ray binaries. There is a further well observed class known as longer period dwarf nova oscillations. In CVs the observed interrelations between these oscillations suggests a model of magnetically controlled accretion onto a rapidly rotating equatorial belt of accreted gas. Non-radial oscillations of the central white dwarf are observed in some systems.

Tagging b and c quark events in e+e- collisions with neural networks

International Nuclear Information System (INIS)

Proriol, J.; Falvard, A.; Henrard, P.; Jousset, J.; Brandl, B.

1992-01-01

High purity samples of b quark events and, if possible, of c quark events are attempted to produce, and the width of Γ(Z 0 → bb-bar) is measured. The different variables and the method to select the most discriminating variables are given. The physical results obtained with these methods are recalled, and new results are presented with variables connected with the impact parameter. Some neural networks used throughout this work and some results on c quark events selection are also presented. (K.A.) 9 refs.; 6 figs

The effects of the massless O(αs2), O(ααs), O(α2) QCD and QED corrections and of the massive contributions to Γ(H0→bb-bar)

International Nuclear Information System (INIS)

Kataev, A.L.

1992-11-01

The expression for the decay width of H 0 →bb-bar process in terms of the b-quark pole mass is presented, with the order O(α s 2 ), O(αα s ) and O(α 2 ) massless corrections and of the order O(m b 2 /M H 2 ) QCD contributions taken into account. The results demonstrate that in the region 50 GeV H ≤2M W the higher order QCD effects reduce the Born expression for Γ Hb( b-bar) by over 50%. The theoretical uncertainties of the QCD predictions for Γ Hb( b-bar) are analyzed in detail. The importance of taking into account of the order O(m b 2 /M H 2 )-corrections for modelling the threshold effects is stressed. (author) 33 refs.; 7 figs