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Sample records for case detection rate

  1. Integration of informal medical practitioners in DOTS implementation to improve case detection rate

    International Nuclear Information System (INIS)

    To integrate informal registered medical practitioners (IRMP) in Directly Observed Therapy Short Course (DOTS) implementation to improve case detection rate. This interventional study was conducted in the settlement area of Malir district whereas New Karachi was taken as control, between February to November 2005. All registered health care providers within 5 kilometer around Tuberculosis (T8) DOTS center Malir were included. New sputum positive and sputum direct smear negative cases of pulmonary Tuberculosis above 15 years residing in the catechumen's area were included as target population. Informal registered medical practitioners were trained for the referral of suspected cases to the TB DOTs center where three sputum samples were taken, and X-ray chest was done to confirm if sputum direct smear (D/S) was negative. Demographic data regarding age, gender, address, case number, onset of symptoms, treatment given, response, compliance to treatment was all collected. Out of 64 health care providers there were a drop out of 6 leaving 58 informal registered medical practitioners (36 homeopathic/ 22 Hakims) who referred 54 cases, of these 16 cases were actual suspects. Two out of these 16 (12.5%) were Tuberculosis positive. One was Sputum D/S positive and the other sputum direct smear negative with X-ray chest positive. Comparison of data (Malir and New Karachi diagnostic center) showed that by incorporating homeopathic and Hakims an increase in the proportion of case identification (0.477) was significantly higher in Malir (intervention area) vs New Karachi (non-intervention area) (0.316). Integration of informal registered medical practitioners was found to be effective in DOTS implementation hence they can be incorporated in other national programmes to improve public health (JPMA 60:33; 2010). (author)

  2. Nonlinear Heart Rate Variability features for real-life stress detection. Case study: students under stress due to university examination

    OpenAIRE

    Melillo Paolo; Bracale Marcello; Pecchia Leandro

    2011-01-01

    Abstract Background This study investigates the variations of Heart Rate Variability (HRV) due to a real-life stressor and proposes a classifier based on nonlinear features of HRV for automatic stress detection. Methods 42 students volunteered to participate to the study about HRV and stress. For each student, two recordings were performed: one during an on-going university examination, assumed as a real-life stressor, and one after holidays. Nonlinear analysis of HRV was performed by using P...

  3. Nonlinear Heart Rate Variability features for real-life stress detection. Case study: students under stress due to university examination

    Directory of Open Access Journals (Sweden)

    Melillo Paolo

    2011-11-01

    Full Text Available Abstract Background This study investigates the variations of Heart Rate Variability (HRV due to a real-life stressor and proposes a classifier based on nonlinear features of HRV for automatic stress detection. Methods 42 students volunteered to participate to the study about HRV and stress. For each student, two recordings were performed: one during an on-going university examination, assumed as a real-life stressor, and one after holidays. Nonlinear analysis of HRV was performed by using Poincaré Plot, Approximate Entropy, Correlation dimension, Detrended Fluctuation Analysis, Recurrence Plot. For statistical comparison, we adopted the Wilcoxon Signed Rank test and for development of a classifier we adopted the Linear Discriminant Analysis (LDA. Results Almost all HRV features measuring heart rate complexity were significantly decreased in the stress session. LDA generated a simple classifier based on the two Poincaré Plot parameters and Approximate Entropy, which enables stress detection with a total classification accuracy, a sensitivity and a specificity rate of 90%, 86%, and 95% respectively. Conclusions The results of the current study suggest that nonlinear HRV analysis using short term ECG recording could be effective in automatically detecting real-life stress condition, such as a university examination.

  4. Value of systematic intervention for chronic obstructive pulmonary disease in a regional Japanese city based on case detection rate and medical cost

    Directory of Open Access Journals (Sweden)

    Tawara Y

    2015-08-01

    Full Text Available Yuichi Tawara,1 Hideaki Senjyu,1 Kenichiro Tanaka,1 Takako Tanaka,1 Masaharu Asai,1 Ryo Kozu,2 Mitsuru Tabusadani,3 Sumihisa Honda,1 Terumitsu Sawai1 1Department of Cardiopulmonary Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; 2Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, Japan; 3Center for Industry, University and Government Cooperation, Nagasaki University, Nagasaki, Japan Objective: We established a COPD taskforce for early detection, diagnosis, treatment, and intervention. We implemented a pilot intervention with a prospective and longitudinal design in a regional city. This study evaluates the usefulness of the COPD taskforce and intervention based on COPD case detection rate and per capita medical costs.Method: We distributed a questionnaire to all 8,878 inhabitants aged 50–89 years, resident in Matsuura, Nagasaki Prefecture in 2006. Potentially COPD-positive persons received a pulmonary function test and diagnosis. We implemented ongoing detection, examination, education, and treatment interventions, performed follow-up examinations or respiratory lessons yearly, and supported the health maintenance of each patient. We compared COPD medical costs in Matsuura and in the rest of Nagasaki Prefecture using data from 2004 to 2013 recorded by the association of Nagasaki National Health Insurance Organization, assessing 10-year means and annual change.Results: As of 2014, 256 people have received a definitive diagnosis of COPD; representing 31% of the estimated total number of COPD patients. Of the cases detected, 87.5% were mild or moderate in severity. COPD medical costs per patient in Matsuura were significantly lower than the rest of Nagasaki Prefecture, as was rate of increase in cost over time.Conclusion: The COPD program in Matsuura enabled early detection and treatment of COPD patients and helped to lower the associated burden of medical costs. The

  5. 75 FR 27375 - Postal Rate Case Management

    Science.gov (United States)

    2010-05-14

    ... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION Postal Rate Case Management AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is seeking comments relevant to management of an anticipated exigent postal rate case. It...

  6. Wearable sensor for heart rate detection

    Science.gov (United States)

    Shi, Cong; Liu, Xiaohua; Kong, Lingqin; Wu, Jizhe; Liu, Ming; Dong, Liquan; Hui, Mei; Zhao, Yuejin

    2015-08-01

    In recent years heart and blood vessel diseases kill more people than everything else combined. The daily test of heart rate for the prevention and treatment of the heart head blood-vessel disease has the vital significance. In order to adapt the transformation of medical model and solve the low accuracy problem of the traditional method of heart rate measuring, we present a new method to monitor heart rate in this paper. The heart rate detection is designed for daily heart rate detection .The heart rate signal is collected by the heart rate sensor. The signal through signal processing circuits converts into sine wave and square wave in turn. And then the signal is transmitted to the computer by data collection card. Finally, we use LABVIEW and MATLAB to show the heart rate wave and calculate the heart rate. By doing contrast experiment with medical heart rate product, experimental results show that the system can realize rapidly and accurately measure the heart rate value. A measurement can be completed within 10 seconds and the error is less than 3beat/min. And the result shows that the method in this paper has a strong anti-interference ability. It can effectively suppress the movement interference. Beyond that the result is insensitive to light.

  7. Application of a conversion factor to estimate the adenoma detection rate from the polyp detection rate.

    LENUS (Irish Health Repository)

    Francis, Dawn L

    2011-03-01

    The adenoma detection rate (ADR) is a quality benchmark for colonoscopy. Many practices find it difficult to determine the ADR because it requires a combination of endoscopic and histologic findings. It may be possible to apply a conversion factor to estimate the ADR from the polyp detection rate (PDR).

  8. Drowsiness detection using heart rate variability.

    Science.gov (United States)

    Vicente, José; Laguna, Pablo; Bartra, Ariadna; Bailón, Raquel

    2016-06-01

    It is estimated that 10-30 % of road fatalities are related to drowsy driving. Driver's drowsiness detection based on biological and vehicle signals is being studied in preventive car safety. Autonomous nervous system activity, which can be measured noninvasively from the heart rate variability (HRV) signal obtained from surface electrocardiogram, presents alterations during stress, extreme fatigue and drowsiness episodes. We hypothesized that these alterations manifest on HRV and thus could be used to detect driver's drowsiness. We analyzed three driving databases in which drivers presented different sleep-deprivation levels, and in which each driving minute was annotated as drowsy or awake. We developed two different drowsiness detectors based on HRV. While the drowsiness episodes detector assessed each minute of driving as "awake" or "drowsy" with seven HRV derived features (positive predictive value 0.96, sensitivity 0.59, specificity 0.98 on 3475 min of driving), the sleep-deprivation detector discerned if a driver was suitable for driving or not, at driving onset, as function of his sleep-deprivation state. Sleep-deprivation state was estimated from the first three minutes of driving using only one HRV feature (positive predictive value 0.80, sensitivity 0.62, specificity 0.88 on 30 drivers). Incorporating drowsiness assessment based on HRV signal may add significant improvements to existing car safety systems. PMID:26780463

  9. Using Advanced Space-borne Radar Technology for Detection and Measurement of Land Subsidence and Interseismic Slip Rates, the Case Study: NW Iran

    Directory of Open Access Journals (Sweden)

    Sadra Karimzadeh

    2013-03-01

    Full Text Available We used synthetic aperture radar interferometry (InSAR to measure land subsidence in Tabriz Plain (TP and strain accumulation along North Tabriz Fault (NTF. Thermal power plant of Tabriz city locats in the area called Tabriz Plain which supplies electric energy for NW Iran. Its facilities need to be constantly cool, so there are more than twenty water pumping stations in some parts of TP. Moreover, the power plant, petrochemical, refinery and Vanyar dam are located near at a hazardous tectonic structure called North Tabriz Fault. InSAR is one of satellite radar observation methods which is used in space geodesy. In this paper, we have applied twenty ASAR SLC images of Envisat satellite from descending orbits during May 2003 to July 2010. InSAR analysis shows about 20mm/yr land subsidence and about 7mm/yr slip rate for NTF.

  10. Tuberculosis case detection in a state prison system.

    OpenAIRE

    Brock, N N; Reeves, M.; LaMarre, M; DeVoe, B

    1998-01-01

    OBJECTIVE: This study was designed to describe the epidemiology of tuberculosis ((TB) among inmates in the Georgia state prison system; to evaluate the effectiveness of the TB case detection methods used; to evaluate the use of contact tracing for inmate TB cases; and to determine rates of completion of therapy. METHODS: Using a standardized form, the authors abstracted data from reports to the Centers for Disease Control and Prevention, prison hospital medical charts, and county health depar...

  11. Additional Fault Detection Test Case Prioritization

    Directory of Open Access Journals (Sweden)

    Ritika Jain

    2013-07-01

    Full Text Available Regression testing is used to confirm that previous bugs have been fixed and that new bugs have not been introduced. Thus regression testing is done during maintenance phase and applied whenever a new version of a program is obtained by modifying an existing version. To perform a regression testing a set of new test cases and old test cases that were previously developed by software engineers are reused. This test suite is exhaustive in nature and it may take long time to rerun all test cases. Thus regression testing is too expensive and the number of test cases increases stridently as the software evolves. In present work, an additional fault detection test case prioritization technique is presented that prioritizes test cases in regression test suite based on number of concealed faults detected by test cases. Both noncost cognizant and cost cognizant prioritization of test cases have been performed using proposed technique and efficiency of prioritized suite is assessed using APFD and APFDc metric respectively.

  12. Case Fatality Rate of Severe Acute Respiratory Syndromes in Beijing

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Objective To describe the case fatality rate of SARS in Beijing. Methods Data of SARS cases notified from Beijing Center for Disease Control and Prevention (BCDC) and supplemented by other channels were collected. The data were analyzed by rate calculation. Results The case fatality rate of SARS in Beijing was 7.66%, and had an ascending trend while the age of cases was getting older, and a descending trend while the epidemic development. The case fatality rate in Beijing was lower than that in other main epidemic countries or regions. Conclusions The risk of death increases with the increment of age of SARS patients. Beijing is successful in controlling and treating SARS.

  13. Trichobezoar detected by ultrasonography: Case report

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Choon Sik; Kim, Myung Jun; Oh, Ki Keun [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    1993-07-15

    The authors experienced a case of gastroduodenojejunal trichobezoar detected by ultrasonographic examination. We thought that tricholbezoar had relatively specific ultrasonographic findings such as a broad hyperechogenic superficial bandlike rim with a complete posterior sonic shadowing and multiple linear echogenic strands on its surface representing hairs, which were better seen after water ingestion. So we were able to get the correct diagnosis of trichobezoar prior to conventional barium studies in a patient who could not be suspected clinically.

  14. Probabilistic pipe fracture evaluations for leak-rate-detection applications

    International Nuclear Information System (INIS)

    Regulatory Guide 1.45, open-quotes Reactor Coolant Pressure Boundary Leakage Detection Systems,close quotes was published by the U.S. Nuclear Regulatory Commission (NRC) in May 1973, and provides guidance on leak detection methods and system requirements for Light Water Reactors. Additionally, leak detection limits are specified in plant Technical Specifications and are different for Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs). These leak detection limits are also used in leak-before-break evaluations performed in accordance with Draft Standard Review Plan, Section 3.6.3, open-quotes Leak Before Break Evaluation Proceduresclose quotes where a margin of 10 on the leak detection limit is used in determining the crack size considered in subsequent fracture analyses. This study was requested by the NRC to: (1) evaluate the conditional failure probability for BWR and PWR piping for pipes that were leaking at the allowable leak detection limit, and (2) evaluate the margin of 10 to determine if it was unnecessarily large. A probabilistic approach was undertaken to conduct fracture evaluations of circumferentially cracked pipes for leak-rate-detection applications. Sixteen nuclear piping systems in BWR and PWR plants were analyzed to evaluate conditional failure probability and effects of crack-morphology variability on the current margins used in leak rate detection for leak-before-break

  15. Probabilistic pipe fracture evaluations for leak-rate-detection applications

    Energy Technology Data Exchange (ETDEWEB)

    Rahman, S.; Ghadiali, N.; Paul, D.; Wilkowski, G. [Battelle, Columbus, OH (United States)

    1995-04-01

    Regulatory Guide 1.45, {open_quotes}Reactor Coolant Pressure Boundary Leakage Detection Systems,{close_quotes} was published by the U.S. Nuclear Regulatory Commission (NRC) in May 1973, and provides guidance on leak detection methods and system requirements for Light Water Reactors. Additionally, leak detection limits are specified in plant Technical Specifications and are different for Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs). These leak detection limits are also used in leak-before-break evaluations performed in accordance with Draft Standard Review Plan, Section 3.6.3, {open_quotes}Leak Before Break Evaluation Procedures{close_quotes} where a margin of 10 on the leak detection limit is used in determining the crack size considered in subsequent fracture analyses. This study was requested by the NRC to: (1) evaluate the conditional failure probability for BWR and PWR piping for pipes that were leaking at the allowable leak detection limit, and (2) evaluate the margin of 10 to determine if it was unnecessarily large. A probabilistic approach was undertaken to conduct fracture evaluations of circumferentially cracked pipes for leak-rate-detection applications. Sixteen nuclear piping systems in BWR and PWR plants were analyzed to evaluate conditional failure probability and effects of crack-morphology variability on the current margins used in leak rate detection for leak-before-break.

  16. Pipe fracture evaluations for leak-rate detection: Deterministic models

    International Nuclear Information System (INIS)

    Regulatory Guide 1.45, Reactor Coolant Pressure Boundary Leakage Detection Systems was published by Nuclear Regulatory Commission (NRC) in May 1973, and its update is being considered. Updating this procedure can involve accounting for the current leak-detection instrumentation capabilities, experience from the accuracy of leak-detection systems in the past, and current analysis methods to assess the significance of the detectable leakage relative to the structural integrity of the plant. In this study, a three-phase effort was undertaken to conduct circumferentially cracked pipe fracture evaluations for applications to leak-rate detection requirement. Results from these probabilistic analyses can be used as a technical basis for future changes to leak-rate detection criterion. In this paper, a state-of-the-art review was conducted to evaluate the adequacy of current deterministic models for thermal-hydraulic analysis for estimation of leak rates, crack-opening area analysis for determination of crack geometry, and elastic-plastic fracture mechanics for prediction of maximum load-carrying capacity of circumferentially cracked piping systems (Phase 1). The results predicted from the above deterministic models were compared with experimental data obtained from the past NRC research programs. Based on the comparisons, it was concluded that the models considered in this study provide reasonably accurate estimates of leak rates, area of crack opening, and maximum load-carrying capacity of circumferentially cracked pipes. These validated deterministic models will be used for subsequent development of novel probabilistic models to evaluate structural reliability of degraded piping systems (Phase 2). Using these models, stochastic pipe fracture evaluation will be conducted for applications to leak-rate detection of piping in boiling water reactor and pressurized water reactor plants (Phase 3)

  17. Expected Detection and False Alarm Rates for Transiting Jovian Planets

    OpenAIRE

    Timothy M Brown

    2003-01-01

    Ground-based searches for transiting Jupiter-sized planets have so far produced few detections of planets, but many of stellar systems with eclipse depths, durations, and orbital periods that resemble those expected from planets. I show that these detection rates are consistent with our present knowledge of binary and multiple-star systems, and of Jovian-mass extrasolar planets. Upcoming space-based searches for transiting Earth-sized planets will be largely unaffected by the sources of false...

  18. Towards a quantitative prediction of the blob detection rate

    Science.gov (United States)

    Fuchert, G.; Carralero, D.; Manz, P.; Stroth, U.; Wolfrum, E.; ASDEX Upgrade Team

    2016-05-01

    To estimate the particle and energy flux to the plasma facing components of a future fusion power plant, the transport carried by filaments of increased pressure, called blobs, is of critical importance. To understand this transport the rate of the filaments has to be known. The novel approach presented here allows the prediction of both the blob generation and detection rates based on background plasma parameters only. The prediction is in a good overall agreement with recent experiments in ASDEX Upgrade.

  19. Rate of return on common equity: Annual survey of gas rate cases

    International Nuclear Information System (INIS)

    The results of the 1989-1990 gas rate survey are represented. The data is a tabular compilation of basic information from natural gas rate orders issued by state public utility commissions throughout the country. It includes a summary of rates of return on common equity approved in rate-making proceedings. The table covers rate orders issued between August 31, 1989, and September 1, 1990. The table provides other basic rate case information besides return on common equity, such as the dollar amount of rate increases applied for and granted, filing dates of the application and order, test year ending dates, and identifying docket or case numbers

  20. Heart rate detection from an electronic weighing scale

    International Nuclear Information System (INIS)

    We propose a novel technique for beat-to-beat heart rate detection based on the ballistocardiographic (BCG) force signal from a subject standing on a common electronic weighing scale. The detection relies on sensing force variations related to the blood acceleration in the aorta, works even if wearing footwear and does not require any sensors attached to the body because it uses the load cells in the scale. We have devised an approach to estimate the sensitivity and frequency response of three commercial weighing scales to assess their capability to detect the BCG force signal. Static sensitivities ranged from 490 nV V−1 N−1 to 1670 nV V−1 N−1. The frequency response depended on the subject's mass but it was broad enough for heart rate estimation. We have designed an electronic pulse detection system based on off-the-shelf integrated circuits to sense heart-beat-related force variations of about 0.24 N. The signal-to-noise ratio of the main peaks of the force signal detected was higher than 30 dB. A Bland–Altman plot was used to compare the RR time intervals estimated from the ECG and BCG force signals for 17 volunteers. The error was ±21 ms, which makes the proposed technique suitable for short-term monitoring of the heart rate

  1. The Impact of Colonoscopy Quality Control Table on Adenoma Detection Rates

    Science.gov (United States)

    Deng, Bin; Zhi, Jiehua; Chen, Yaosheng; Liang, Lanyu; Wu, Jian; Gao, Xuefen; Xiao, Weiming; Ding, Yanbing

    2016-01-01

    Objective. This study aims to investigate the effects of reporting colonoscopy findings and the regular review of outcomes on adenoma detection rates. Methods. Patients who underwent colonoscopy from August 2013 to February 2014 were selected as the intervention group. The preintervention group included patients who underwent colonoscopy from January 2013 to July 2013, in which the procedure sheet for this group of patients was not accomplished. The primary outcome was adenoma detection rate (ADR), and secondary outcomes included the success rate of intubation and withdrawal time. Results. This study included 2,467 cases: 1,302 cases in the intervention group and 1,165 cases in the preintervention group. There was no significant difference in demographic characteristics between the two groups. In the intervention group, withdrawal time of colonoscopy was longer (P quality indicators of colonoscopy.

  2. Energy efficiency rating of districts, case Finland

    International Nuclear Information System (INIS)

    There is an increasing political pressure on the city planning to create more energy efficient city plans. Not only do the city plans have to enable and promote energy efficient solutions, but it also needs to be clearly assessed how energy efficient the plans are. City planners often have no or poor know how about energy efficiency and building technologies which makes it difficult for them to answer to this need without new guidelines and tools. An easy to use tool for the assessment of the energy efficiency of detailed city plans was developed. The aim of the tool is for city planners to easily be able to assess the energy efficiency of the proposed detailed city plan and to be able to compare the impacts of changes in the plan. The tool is designed to be used with no in-depth knowledge about energy or building technology. With a wide use of the tool many missed opportunities for improving energy efficiency can be avoided. It will provide better opportunities for sustainable solutions leading to less harmful environmental impact and reduced emissions. - Highlights: • We have created a tool for assessing energy efficiency of detailed city plans. • The energy source is the most important factor for efficiency of districts in Finland. • Five case districts in Finland were analyzed. • In this paper one residential district has in-depth sensitivity analyses done

  3. Respiratory rate detection algorithms by photoplethysmography signal processing.

    Science.gov (United States)

    Lee, E M; Kim, N H; Trang, N T; Hong, J H; Cha, E J; Lee, T S

    2008-01-01

    Photoplethysmography (PPG) offers the clinically meaningful parameters, such as, heart rate, and respiratory rate. In this study, we presented three respiratory signal detection algorithms using photoplethysmography raw data generated from commercial PPG sensor: (1)Min-Max (2)Peak-to-Peak (3)Pulse Shape. As reference signal, nasal sensor signal was acquired simultaneously and compared and analyzed. We used two types of moving average filtering technique to process three PPG parameters. In laboratory experiment, 6 subjects' PPG signals were measured when they respire ten and fifteen, and arbitrary times per minute. From the results, following conclusions were drawn. Min-Max and Peak-to-Peak algorithms perform better than Pulse shape algorithm. They can be used to detect respiratory rate. But, Pulse Shape algorithm was accurate for subject 4 only. More experimental data is necessary to improve the accuracy and reliability. PMID:19162865

  4. Minimum Symbol Error Rate Detection in Single-Input Multiple-Output Channels with Markov Noise

    DEFF Research Database (Denmark)

    Christensen, Lars P.B.

    2005-01-01

    Minimum symbol error rate detection in Single-Input Multiple- Output(SIMO) channels with Markov noise is presented. The special case of zero-mean Gauss-Markov noise is examined closer as it only requires knowledge of the second-order moments. In this special case, it is shown that optimal detection...... can be achieved by a Multiple-Input Multiple- Output(MIMO) whitening filter followed by a traditional BCJR algorithm. The Gauss-Markov noise model provides a reasonable approximation for co-channel interference, making it an interesting single-user detector for many multiuser communication systems...

  5. Heart rate analysis by sparse representation for acute pain detection.

    Science.gov (United States)

    Tejman-Yarden, Shai; Levi, Ofer; Beizerov, Alex; Parmet, Yisrael; Nguyen, Tu; Saunders, Michael; Rudich, Zvia; Perry, James C; Baker, Dewleen G; Moeller-Bertram, Tobias

    2016-04-01

    Objective pain assessment methods pose an advantage over the currently used subjective pain rating tools. Advanced signal processing methodologies, including the wavelet transform (WT) and the orthogonal matching pursuit algorithm (OMP), were developed in the past two decades. The aim of this study was to apply and compare these time-specific methods to heart rate samples of healthy subjects for acute pain detection. Fifteen adult volunteers participated in a study conducted in the pain clinic at a single center. Each subject's heart rate was sampled for 5-min baseline, followed by a cold pressor test (CPT). Analysis was done by the WT and the OMP algorithm with a Fourier/Wavelet dictionary separately. Data from 11 subjects were analyzed. Compared to baseline, The WT analysis showed a significant coefficients' density increase during the pain incline period (p algorithm (p algorithm (p detection of pain events. Statistical analysis proved the OMP to be by far more specific allowing the Fourier coefficients to represent the signal's basic harmonics and the wavelet coefficients to focus on the time-specific painful event. This is an initial study using OMP for pain detection; further studies need to prove the efficiency of this system in different settings. PMID:26264057

  6. Stress Detection Using Low Cost Heart Rate Sensors

    Directory of Open Access Journals (Sweden)

    Mario Salai

    2016-01-01

    Full Text Available The automated detection of stress is a central problem for ambient assisted living solutions. The paper presents the concepts and results of two studies targeted at stress detection with a low cost heart rate sensor, a chest belt. In the device validation study (n=5, we compared heart rate data and other features from the belt to those measured by a gold standard device to assess the reliability of the sensor. With simple synchronization and data cleaning algorithm, we were able to select highly (>97% correlated, low average error (2.2% data segments of considerable length from the chest data for further processing. The protocol for the clinical study (n=46 included a relax phase followed by a phase with provoked mental stress, 10 minutes each. We developed a simple method for the detection of the stress using only three time-domain features of the heart rate signal. The method produced accuracy of 74.6%, sensitivity of 75.0%, and specificity of 74.2%, which is impressive compared to the performance of two state-of-the-art methods run on the same data. Since the proposed method uses only time-domain features, it can be efficiently implemented on mobile devices.

  7. Pipe fracture evaluations for leak-rate detection: Probabilistic models

    International Nuclear Information System (INIS)

    This is the second in series of three papers generated from studies on nuclear pipe fracture evaluations for leak-rate detection. This paper focuses on the development of novel probabilistic models for stochastic performance evaluation of degraded nuclear piping systems. It was accomplished here in three distinct stages. First, a statistical analysis was conducted to characterize various input variables for thermo-hydraulic analysis and elastic-plastic fracture mechanics, such as material properties of pipe, crack morphology variables, and location of cracks found in nuclear piping. Second, a new stochastic model was developed to evaluate performance of degraded piping systems. It is based on accurate deterministic models for thermo-hydraulic and fracture mechanics analyses described in the first paper, statistical characterization of various input variables, and state-of-the-art methods of modem structural reliability theory. From this model. the conditional probability of failure as a function of leak-rate detection capability of the piping systems can be predicted. Third, a numerical example was presented to illustrate the proposed model for piping reliability analyses. Results clearly showed that the model provides satisfactory estimates of conditional failure probability with much less computational effort when compared with those obtained from Monte Carlo simulation. The probabilistic model developed in this paper will be applied to various piping in boiling water reactor and pressurized water reactor plants for leak-rate detection applications

  8. High rates of detection of respiratory viruses in tonsillar tissues from children with chronic adenotonsillar disease.

    Directory of Open Access Journals (Sweden)

    Jose Luiz Proenca-Modena

    Full Text Available Chronic tonsillar diseases are an important health problem, leading to large numbers of surgical procedures worldwide. Little is known about pathogenesis of these diseases. In order to investigate the role of respiratory viruses in chronic adenotonsillar diseases, we developed a cross-sectional study to determine the rates of viral detections of common respiratory viruses detected by TaqMan real time PCR (qPCR in nasopharyngeal secretions, tonsillar tissues and peripheral blood from 121 children with chronic tonsillar diseases, without symptoms of acute respiratory infections. At least one respiratory virus was detected in 97.5% of patients. The viral co-infection rate was 69.5%. The most frequently detected viruses were human adenovirus in 47.1%, human enterovirus in 40.5%, human rhinovirus in 38%, human bocavirus in 29.8%, human metapneumovirus in 17.4% and human respiratory syncytial virus in 15.7%. Results of qPCR varied widely between sample sites: human adenovirus, human bocavirus and human enterovirus were predominantly detected in tissues, while human rhinovirus was more frequently detected in secretions. Rates of virus detection were remarkably high in tonsil tissues: over 85% in adenoids and close to 70% in palatine tonsils. In addition, overall virus detection rates were higher in more hypertrophic than in smaller adenoids (p = 0.05, and in the particular case of human enteroviruses, they were detected more frequently (p = 0.05 in larger palatine tonsils than in smaller ones. While persistence/latency of DNA viruses in tonsillar tissues has been documented, such is not the case of RNA viruses. Respiratory viruses are highly prevalent in adenoids and palatine tonsils of patients with chronic tonsillar diseases, and persistence of these viruses in tonsils may stimulate chronic inflammation and play a role in the pathogenesis of these diseases.

  9. A PC-aided optical foetal heart rate detection system.

    Science.gov (United States)

    Oweis, Rami J; As'ad, Hala; Aldarawsheh, Amany; Al-Khdeirat, Rawan; Lwissy, Kaldoun

    2014-01-01

    Safe monitoring of foetal heart rate is a valuable tool for the healthy evolution and wellbeing of both foetus and mother. This paper presents a non-invasive optical technique that allows for foetal heart rate detection using a photovoltaic infrared (IR) detector placed on the mother's abdomen. The system presented here consists of a photoplethysmography (PPG) circuit, abdomen circuit and a personal computer equipped with MATLAB. A near IR beam having a wavelength of 880 nm is transmitted through the mother's abdomen and foetal tissue. The received abdominal signal that conveys information pertaining to the mother and foetal heart rate is sensed by a low noise photodetector. The PC receives the signal through the National Instrumentation Data Acquisition Card (NIDAQ). After synchronous detection of the abdominal and finger PPG signals, the designed MATLAB-based software saves, analyses and extracts information related to the foetal heart rate. Extraction is carried out using recursive least squares adaptive filtration. Measurements on eight pregnant women with gestational periods ranging from 35-39 weeks were performed using the proposed system and CTG. Results show a correlation coefficient of 0.978 and a correlation confidence interval between 88-99.6%. The t test results in a p value of 0.034, which is less than 0.05. Low power, low cost, high signal-to-noise ratio, reduction of ambient light effect and ease of use are the main characteristics of the proposed system. PMID:24195701

  10. Laffer Taxation Rate: Estimations For Romania’S Case

    OpenAIRE

    Elena Pădurean; Andreea Stoian; Emilia Câmpeanu

    2011-01-01

    The relationship between taxation rate and tax revenues for the public budget has generated an important debate aiming that level of taxation rate that maximizes tax revenues collected for the public budget. Laffer curve involves the existence of a strong correlation between taxation rate and tax revenues. The aim of this paper is to estimate a Laffer taxation rate for Romania’s case using annual data over the period 1990-2008. The main findings highlight that a taxation rate higher than 28% ...

  11. Motion-compensated non-contact detection of heart rate

    Science.gov (United States)

    Yang, Lei; Liu, Ming; Dong, Liquan; Zhao, Yuejin; Liu, Xiaohua

    2015-12-01

    A new non-contact heart rate detection method based on the dual-wavelength technique is proposed and demonstrated experimentally. It is a well-known fact that the differences in the circuits of two detection modules result in different responses of two modules for motion artifacts. This poses a great challenge to compensate the motion artifacts during measurements. In order to circumvent this problem, we have proposed the amplitude spectrum and phase spectrum adaptive filter. Comparing with the time-domain adaptive filter and independent component analysis, the amplitude spectrum and phase spectrum adaptive filter can suppress the interference caused by the two circuit differences and effectively compensate the motion artifacts. To make the device is much compact and portable, a photoelectric probe is designed. The measurement distance is from several centimeters up to several meters. Moreover, the data obtained by using this non-contact detection system is compared with those of the conventional finger blood volume pulse (BVP) sensor by simultaneously measuring the heart rate of the subject. The data obtained from the proposed non-contact system are consistent and comparable with that of the BVP sensor.

  12. A change detection approach to moving object detection in low fame-rate video

    Science.gov (United States)

    Porter, Reid; Harvey, Neal; Theiler, James

    2009-05-01

    Moving object detection is of significant interest in temporal image analysis since it is a first step in many object identification and tracking applications. A key component in almost all moving object detection algorithms is a pixellevel classifier, where each pixel is predicted to be either part of a moving object or part of the background. In this paper we investigate a change detection approach to the pixel-level classification problem and evaluate its impact on moving object detection. The change detection approach that we investigate was previously applied to multi- and hyper-spectral datasets, where images were typically taken several days, or months apart. In this paper, we apply the approach to lowframe rate (1-2 frames per second) video datasets.

  13. A change detection approach to moving object detection in low frame-rate video

    Energy Technology Data Exchange (ETDEWEB)

    Porter, Reid B [Los Alamos National Laboratory; Harvey, Neal R [Los Alamos National Laboratory; Theiler, James P [Los Alamos National Laboratory

    2009-01-01

    Moving object detection is of significant interest in temporal image analysis since it is a first step in many object identification and tracking applications. A key component in almost all moving object detection algorithms is a pixel-level classifier, where each pixel is predicted to be either part of a moving object or part of the background. In this paper we investigate a change detection approach to the pixel-level classification problem and evaluate its impact on moving object detection. The change detection approach that we investigate was previously applied to multi-and hyper-spectral datasets, where images were typically taken several days, or months apart. In this paper, we apply the approach to low-frame rate (1-2 frames per second) video datasets.

  14. [Detection of Heart Rate of Fetal ECG Based on STFT and BSS].

    Science.gov (United States)

    Wang, Xu; Cai, Kun

    2016-01-01

    Changes in heart rate of fetal is function regulating performance of the circulatory system and the central nervous system, it is significant to detect heart rate of fetus in perinatal fetal. This paper puts forward the fetal heart rate detection method based on short time Fourier transform and blind source separation. First of all, the mixed ECG signal was preprocessed, and then the wavelet transform technique was used to separate the fetal ECG signal with noise from mixed ECG signal, after that, the short-time Fourier transform and the blind separation were carried on it, and then calculated the correlation coefficient of it, Finally, An independent component that it has strongest correlation with the original signal was selected to make FECG peak detection and calculated the fetal instantaneous heart rate. The experimental results show that the method can improve the detection rate of the FECG peak (R), and it has high accuracy in fixing peak(R) location in the case of low signal-noise ratio. PMID:27197491

  15. Local dynamics of heart rate: detection and prognostic implications

    International Nuclear Information System (INIS)

    The original observation that reduced heart rate variability (HRV) confers poor prognosis after myocardial infarction has been followed by many studies of heart rate dynamics. We tested the hypothesis that an entropy-based local dynamics measure gave prognostic information in ambulatory patients undergoing 24-h electrocardiography. In this context, entropy is the probability that short templates will find matches in the time series. We studied RR interval time series from 24-h Holter monitors of 1564 consecutive patients over age 39. We generated histograms of the count of templates as a function of the number of templates matches in short RR interval time series, and found characteristic appearance of histograms for atrial fibrillation, sinus rhythm with normal HRV, and sinus rhythm with reduced HRV and premature ventricular contractions (PVCs). We developed statistical models to detect the abnormal dynamic phenotype of reduced HRV with PVCs and fashioned a local dynamics score (LDs) that, after controlling for age, added more prognostic information than other standard risk factors and common HRV metrics, including, to our surprise, the PVC count and the HRV of normal-to-normal intervals. Addition of the LDs to a predictive model using standard risk factors significantly increased the ROC area and the net reclassification improvement was 27%. We conclude that abnormal local dynamics of heart rate confer adverse prognosis in patients undergoing 24-h ambulatory electrocardiography. (paper)

  16. Local dynamics of heart rate: detection and prognostic implications.

    Science.gov (United States)

    Moss, Travis J; Lake, Douglas E; Moorman, J Randall

    2014-10-01

    The original observation that reduced heart rate variability (HRV) confers poor prognosis after myocardial infarction has been followed by many studies of heart rate dynamics. We tested the hypothesis that an entropy-based local dynamics measure gave prognostic information in ambulatory patients undergoing 24-h electrocardiography. In this context, entropy is the probability that short templates will find matches in the time series. We studied RR interval time series from 24-h Holter monitors of 1564 consecutive patients over age 39. We generated histograms of the count of templates as a function of the number of templates matches in short RR interval time series, and found characteristic appearance of histograms for atrial fibrillation, sinus rhythm with normal HRV, and sinus rhythm with reduced HRV and premature ventricular contractions (PVCs). We developed statistical models to detect the abnormal dynamic phenotype of reduced HRV with PVCs and fashioned a local dynamics score (LDs) that, after controlling for age, added more prognostic information than other standard risk factors and common HRV metrics, including, to our surprise, the PVC count and the HRV of normal-to-normal intervals. Addition of the LDs to a predictive model using standard risk factors significantly increased the ROC area and the net reclassification improvement was 27%. We conclude that abnormal local dynamics of heart rate confer adverse prognosis in patients undergoing 24-h ambulatory electrocardiography. PMID:25229393

  17. Growth rate and characteristics of breast cancers detected by ultrasonography screening

    International Nuclear Information System (INIS)

    Breast cancer screening was carried out at our institution in a ''Human Dock'' style health check, by inspection and palpation, together with ultrasonography. Breast cancers detected were reviewed and the utility of ultrasonography was evaluated. A total of 14,063 women underwent the screening and the results were good, with a recall rate of 3.4%, a cancer detection rate of 0.30%, and a positive predictive value of 8.7%. Of 42 breast cancers detected by ultrasonography, 30 (71%) were 1.5 cm or less in diameter. For breast cancers detected by inspection and palpation, the detection rate for small cancers measuring 1.5 cm or less was 33% (10 out of 30 women), and 100% (12 women) for tumors measuring more than 1.5 cm. The cancer detection rate by mammography was 39% (9 out of 23 cancers) for tumors measuring 1.5 cm or less, and 91% (10 out of 11 cases) for those larger than 1.5 cm. Thus cancer detection by ultrasonography was optimal for tumors measuring 1.5 cm or less. Histologically proven lymph node metastasis was positive in 8 (25%) of 32 patients, among whom some had primary cancers measuring 1.5 cm or less. Tumor volume doubling time (TVDT) was measurable in 10 women; there was no change in size in one instance, and in the others TVDT was 4.8 to 32.5 months (mean 15.5 months), small cancers approximately 1 cm in size having a long TVDT. In women whose cancer size could be determined twice or more, TVDT tended to be short when a cancer measured about 1 cm or more. Cancers with a long TVDT showed low histological malignancy, and thus detection of breast cancers with a long TVDT at screening appears to be rewarding. (author)

  18. Worst-Case Portfolio Optimization under Stochastic Interest Rate Risk

    Directory of Open Access Journals (Sweden)

    Tina Engler

    2014-12-01

    Full Text Available We investigate a portfolio optimization problem under the threat of a market crash, where the interest rate of the bond is modeled as a Vasicek process, which is correlated with the stock price process. We adopt a non-probabilistic worst-case approach for the height and time of the market crash. On a given time horizon [0; T], we then maximize the investor’s expected utility of terminal wealth in the worst-case crash scenario. Our main result is an explicit characterization of the worst-case optimal portfolio strategy for the class of HARA (hyperbolic absolute risk aversion utility functions.

  19. Routine perinatal and paediatric post-mortem radiography: detection rates and implications for practice

    International Nuclear Information System (INIS)

    Routine perinatal and paediatric post-mortem plain radiography allows for the diagnosis and assessment of skeletal dysplasias, fractures and other bony abnormalities. The aim of this study was to review the diagnostic yield of this practice. We identified 1,027 cases performed in a single institution over a 21/2-year period, including babygrams (whole-body examinations) and full skeletal surveys. Images were reported prior to autopsy in all cases. Radiology findings were cross-referenced with the autopsy findings using an autopsy database. We scored each case from 0 to 4 according to the level of diagnostic usefulness. The overall abnormality rate was 126/1,027 (12.3%). There was a significantly higher rate of abnormality when a skeletal survey was performed (18%) rather than a babygram (10%; P < 0.01); 90% (665/739) of babygrams were normal. Of the 74 abnormal babygrams, we found 33 incidental non-contributory cases, 19 contributory, 20 diagnostic, and 2 false-positive cases. There were only 2 cases out of 739 (0.27%) in whom routine post-mortem imaging identified potentially significant abnormalities that would not have been detected if only selected imaging had been performed. A policy of performing selected, rather than routine, foetal post-mortem radiography could result in a significant cost saving. Routine post-mortem paediatric radiography in foetuses and neonates is neither diagnostically useful nor cost-effective. A more evidence-based, selective protocol should yield significant cost savings. (orig.)

  20. Routine perinatal and paediatric post-mortem radiography: detection rates and implications for practice

    Energy Technology Data Exchange (ETDEWEB)

    Arthurs, Owen J. [NHS Foundation Trust, Department of Radiology Great Ormond Street Hospital for Children, London (United Kingdom); University College London, Institute of Child Health, London (United Kingdom); Calder, Alistair D. [NHS Foundation Trust, Department of Radiology Great Ormond Street Hospital for Children, London (United Kingdom); Kiho, Liina [Camelia Botnar Laboratories Great Ormond Street Hospital for Children, Department of Paediatric Pathology, London (United Kingdom); Taylor, Andrew M. [Great Ormond Street Hospital for Children, Cardiorespiratory Unit, London (United Kingdom); UCL Institute of Cardiovascular Science, London (United Kingdom); University College London, Institute of Child Health, London (United Kingdom); Sebire, Neil J. [Camelia Botnar Laboratories Great Ormond Street Hospital for Children, Department of Paediatric Pathology, London (United Kingdom); University College London, Institute of Child Health, London (United Kingdom)

    2014-03-15

    Routine perinatal and paediatric post-mortem plain radiography allows for the diagnosis and assessment of skeletal dysplasias, fractures and other bony abnormalities. The aim of this study was to review the diagnostic yield of this practice. We identified 1,027 cases performed in a single institution over a 21/2-year period, including babygrams (whole-body examinations) and full skeletal surveys. Images were reported prior to autopsy in all cases. Radiology findings were cross-referenced with the autopsy findings using an autopsy database. We scored each case from 0 to 4 according to the level of diagnostic usefulness. The overall abnormality rate was 126/1,027 (12.3%). There was a significantly higher rate of abnormality when a skeletal survey was performed (18%) rather than a babygram (10%; P < 0.01); 90% (665/739) of babygrams were normal. Of the 74 abnormal babygrams, we found 33 incidental non-contributory cases, 19 contributory, 20 diagnostic, and 2 false-positive cases. There were only 2 cases out of 739 (0.27%) in whom routine post-mortem imaging identified potentially significant abnormalities that would not have been detected if only selected imaging had been performed. A policy of performing selected, rather than routine, foetal post-mortem radiography could result in a significant cost saving. Routine post-mortem paediatric radiography in foetuses and neonates is neither diagnostically useful nor cost-effective. A more evidence-based, selective protocol should yield significant cost savings. (orig.)

  1. Is the Mattis Dementia Rating Scale appropriate to detect Mild Cognitive Impairment?

    Directory of Open Access Journals (Sweden)

    Anabel Belaus

    2015-07-01

    Full Text Available Some studies have tried to assess the Mattis Dementia Rating Scale (MDRS capability to detect incipient dementia or Mild Cognitive Impairment (MCI, but the results are not clear. The aim of this research was to evaluate the sensitivity and specificity of the MDRS, and to localize the optimal cutoff score for MCI. Methodology. A neuropsychological battery that included the MDRS was administered to 60 older adults of both genders (Mean age=68.38, SD=6.80 in Cór- doba, Argentina, who were then classified as “Control” (34 cases or “MCI” (26 cases according to performance in the neuropsychological evaluation, excluding the MDRS. The criteria used were those stated by the Sociedad Española de Neurología. We performed mean comparisons in order to evaluate if the MDRS was able to detect the group differences. Then, a logistic regression with the MDRS total score as the predictor variable and the group as the criterion variable was performed to determine the cutoff score. Results. Even though the mean comparisons showed a significant difference in the MDRS (p=.004, the diagnostic accuracy was only 63% with a 133 points cutoff score. The sensitivity was 42% and the specificity was 79%. Conclusions. The MDRS does not seem to be a useful tool to detect MCI since it generates numerous misclassified cases. The development of more accurate tools becomes fundamental in order to detect MCI.

  2. Predicting the capture rate in the Sun from a direct detection signal independently of the astrophysics

    Science.gov (United States)

    Herrero-Garcia, Juan

    2016-05-01

    The goal of the works on which this talk is based is to relate a direct detection signal with neutrino limits from the Sun independently of the astrophysics. In order to achieve this we derive a halo-independent lower bound on the dark matter capture rate in the Sun from a direct detection signal, with which one can set upper limits on the branching ratios into different channels from the absence of a high-energy neutrino flux in neutrino observatories. We also extend this bound to the case of inelastic scattering, both endothermic and exothermic. From two inelastic signals we show how the dark matter mass, the mass difference of the states and the couplings to neutrons and protons can be obtained. Furthermore, one can also pin down the exothermic/endothermic nature of the scattering, and therefore a precise lower bound on the solar capture rate is predicted. We also discuss isospin violation and uncertainties due to form factors.

  3. Biometric Quantization through Detection Rate Optimized Bit Allocation

    Directory of Open Access Journals (Sweden)

    C. Chen

    2009-01-01

    Full Text Available Extracting binary strings from real-valued biometric templates is a fundamental step in many biometric template protection systems, such as fuzzy commitment, fuzzy extractor, secure sketch, and helper data systems. Previous work has been focusing on the design of optimal quantization and coding for each single feature component, yet the binary string—concatenation of all coded feature components—is not optimal. In this paper, we present a detection rate optimized bit allocation (DROBA principle, which assigns more bits to discriminative features and fewer bits to nondiscriminative features. We further propose a dynamic programming (DP approach and a greedy search (GS approach to achieve DROBA. Experiments of DROBA on the FVC2000 fingerprint database and the FRGC face database show good performances. As a universal method, DROBA is applicable to arbitrary biometric modalities, such as fingerprint texture, iris, signature, and face. DROBA will bring significant benefits not only to the template protection systems but also to the systems with fast matching requirements or constrained storage capability.

  4. Day case surgery: geographical variation, trends and readmission rates.

    OpenAIRE

    Henderson, J.; Goldacre, M J; Griffith, M.; Simmons, H M

    1989-01-01

    Data from the Oxford Record Linkage Study were analysed to determine the amount of work undertaken in day case surgery for 12 surgical conditions in five districts in the Oxford Region during the years 1976 to 1985. Record linkage was used to study readmission rates, comparing day surgery with inpatient care. The use of day surgery gradually increased in some conditions (eg, termination of pregnancy, female sterilisation) but did not increase from a fairly low base for others (eg, inguinal he...

  5. A coincidence detection algorithm for improving detection rates in coulomb explosion imaging

    International Nuclear Information System (INIS)

    A scheme for determining true coincidence events in Coulomb Explosion Imaging experiments is reported and compared with a simple design used in recently published work. The new scheme is able to identify any possible coincidence without the use of a priori knowledge of the fragmentation mechanism. Using experimental data from the triatomic molecule OCS, the advanced algorithm is shown to improve acquisition yield by a factor of between 2 and 6 depending on the amount of a priori knowledge included in the simple design search. Monte Carlo simulations for both systems suggest that detection yield can be improved by increasing the number of molecules in the laser focus from the standard ≤1 up to 3.5 and employing the advanced algorithm. Count rates for larger molecules would be preferentially improved with the rate for 6 atom molecules improved by a factor of up to five.

  6. Using uterine activity to improve fetal heart rate variability analysis for detection of asphyxia during labor.

    Science.gov (United States)

    Warmerdam, G J J; Vullings, R; Van Laar, J O E H; Van der Hout-Van der Jagt, M B; Bergmans, J W M; Schmitt, L; Oei, S G

    2016-03-01

    During labor, uterine contractions can cause temporary oxygen deficiency for the fetus. In case of severe and prolonged oxygen deficiency this can lead to asphyxia. The currently used technique for detection of asphyxia, cardiotocography (CTG), suffers from a low specificity. Recent studies suggest that analysis of fetal heart rate variability (HRV) in addition to CTG can provide information on fetal distress. However, interpretation of fetal HRV during labor is difficult due to the influence of uterine contractions on fetal HRV. The aim of this study is therefore to investigate whether HRV features differ during contraction and rest periods, and whether these differences can improve the detection of asphyxia. To this end, a case-control study was performed, using 14 cases with asphyxia that were matched with 14 healthy fetuses. We did not find significant differences for individual HRV features when calculated over the fetal heart rate without separating contractions and rest periods (p  >  0.30 for all HRV features). Separating contractions from rest periods did result in a significant difference. In particular the ratio between HRV features calculated during and outside contractions can improve discrimination between fetuses with and without asphyxia (p  <  0.04 for three out of four ratio HRV features that were studied in this paper). PMID:26862891

  7. The directional rate and the modulation effect for direct supersymmetric matter detection

    International Nuclear Information System (INIS)

    The detection of the theoretically expected dark matter is central to particle physics and cosmology. Current fashionable supersymmetric models provide a natural dark matter candidate which is the lightest supersymmetric particle (LSP). Such models, combined with fairly well understood physics like the quark substructure of the nucleon and the nuclear structure (form factor and/or spin response function), permit the evaluation of the event rate for LSP-nucleus elastic scattering. The thus obtained event rates are, however, very low or even undetectable. So it is imperative to exploit the modulation effect, i.e., the dependence of the event rate on the Earth's annual motion. Also it is useful to consider the directional rate, i.e., its dependence on the direction of the recoiling nucleus. We study such a modulation effect both in non-directional and directional experiments. We calculate both the differential and the total rates using isothermal, symmetric as well as only axially asymmetric, and non-isothermal, due to caustic rings, velocity distributions. We find that in the symmetric case the modulation amplitude is small. The same is true for the case of caustic rings. The inclusion of asymmetry, with a realistic enhanced velocity dispersion in the galactocentric direction, yields an enhanced modulation effect, especially in directional experiments

  8. High False-Positive Rate of Cytokeratin-19 in Detecting Circulating Tumor Cells for Nasopharyngeal Carcinoma

    Directory of Open Access Journals (Sweden)

    Ruey-Ho Kao

    2002-04-01

    Full Text Available Background: Nasopharyngeal carcinoma (NPC harbors a higher metastatic potential thanother head and neck cancers. In order to seek a possible surrogate marker forearly detection of recurrent or metastatic disease, we tested the feasibility ofcytokeratin-19 (CK-19-nested reverse-transcription polymerase chain reaction(RT-PCR for detecting circulating tumor cells in NPC patients.Methods: Two tubes of blood were sequentially collected in individual draws from 7NPC patients and 15 healthy persons. Total ribonucleic acid (RNA wasextracted from blood cells and treated with deoxyribonuclease. The RNAwas then subjected to RT and nested PCR with specific CK-19 primers. Thereaction products were run on an agarose gel and visualized under UV light.The sequences of the products were determined using an ABI377 automaticsequencer.Results: Among the 7 NPC cases, 4 cases presented CK-19 expression with 2 in bothtubes, 1 in the first tube, and 1 in the second tube. In the control group, 8 of15 cases also presented CK-19 expression with 6 in both tubes and 2 in thesecond tube resulting in a 53.3% false-positive rate. Incidentally, an aberrantsplicing product lacking exon 4 of CK-19 messenger RNA was discovered.Conclusion: Results of the present study indicate that the CK-19-nested RT-PCR is notsuitable for detecting circulating tumor cells in NPC patients because of ahigh false-positive rate in the control group. The reason for the high rate offalse-positives may be attributed to pseudogenes, different blood cell separationmethods, or illegitimate expression of CK-19 in blood cells.

  9. Detection relic gravitational waves in thermal case

    CERN Document Server

    Ghayour, Basem

    2016-01-01

    The thermal spectrum of relic gravitational waves causes the new amplitude that called `modified amplitude'. Our analysis shows that, there exist some chances for detection of the thermal spectrum in addition to the usual spectrum by Adv.LIGO and Dml detectors. The behaviour of the inflation and reheating stages are often known as power law expansion like $S(\\eta)\\propto \\eta^{1+\\beta}$, $S(\\eta)\\propto \\eta^{1+\\beta_s}$ respectively. The $\\beta$ and $\\beta_s$ have an unique effect on the shape of the spectrum. We find some upper bounds on the $\\beta$ and $\\beta_s$ by comparison the usual and thermal spectrum with the Adv.LIGO and Dml. As this result gives us more information about the nature of the evolution of inflation and reheating stages.

  10. MIMO Detection Algorithms for High Data Rate Wireless Transmission

    CERN Document Server

    Sinha, Nirmalendu Bikas; Mitra, M

    2010-01-01

    Motivated by MIMO broad-band fading channel model, in this section a comparative study is presented regarding various uncoded adaptive and non-adaptive MIMO detection algorithms with respect to BER/PER performance, and hardware complexity. All the simulations are conducted within MIMO-OFDM framework and with a packet structure similar to that of IEEE 802.11a/g standard. As the comparison results show, the RLS algorithm appears to be an affordable solution for wideband MIMO system targeting at Giga-bit wireless transmission. So MIMO can overcome huge processing power required for MIMO detection by using optimizing channel coding and MIMO detection.

  11. Gait Event Detection during Stair Walking Using a Rate Gyroscope

    Science.gov (United States)

    Formento, Paola Catalfamo; Acevedo, Ruben; Ghoussayni, Salim; Ewins, David

    2014-01-01

    Gyroscopes have been proposed as sensors for ambulatory gait analysis and functional electrical stimulation systems. These applications often require detection of the initial contact (IC) of the foot with the floor and/or final contact or foot off (FO) from the floor during outdoor walking. Previous investigations have reported the use of a single gyroscope placed on the shank for detection of IC and FO on level ground and incline walking. This paper describes the evaluation of a gyroscope placed on the shank for determination of IC and FO in subjects ascending and descending a set of stairs. Performance was compared with a reference pressure measurement system. The absolute mean difference between the gyroscope and the reference was less than 45 ms for IC and better than 135 ms for FO for both activities. Detection success was over 93%. These results provide preliminary evidence supporting the use of a gyroscope for gait event detection when walking up and down stairs. PMID:24651724

  12. Determining an Appropriate Weight attribute in Fraud Call Rate Data Using Case Based Reasoning

    Directory of Open Access Journals (Sweden)

    Musa Bala Shuaibu

    2014-03-01

    Full Text Available Fraud cases are significantly causing huge revenue losses in telecommunication companies around the world. Although previous cases are very important data in dealing with fraud patterns, there are variations in the dataset of different fraud case scenarios which in turns need specific detection system without necessarily involving the domain expert directly. This paper investigates the appropriate weight values for attributes using fraud Call Rate Data that is based on Artificial Intelligence technique (Case Based Reasoning with a meaningful confidence in telecommunication data. The experimental result on the fraud data reports that the weight for all attribute used in this study needs to be set at 0.9 in order to get the best performance of 98.33%.

  13. Time-Frequency Analysis of Heart Rate Variability for Neonatal Seizure Detection

    Science.gov (United States)

    Malarvili, M. B.; Mesbah, Mostefa; Boashash, Boualem

    2007-12-01

    There are a number of automatic techniques available for detecting epileptic seizures using solely electroencephalogram (EEG), which has been the primary diagnosis tool in newborns. The electrocardiogram (ECG) has been much neglected in automatic seizure detection. Changes in heart rate and ECG rhythm were previously linked to seizure in case of adult humans and animals. However, little is known about heart rate variability (HRV) changes in human neonate during seizure. In this paper, we assess the suitability of HRV as a tool for seizure detection in newborns. The features of HRV in the low-frequency band (LF: 0.03-0.07 Hz), mid-frequency band (MF: 0.07-0.15 Hz), and high-frequency band (HF: 0.15-0.6 Hz) have been obtained by means of the time-frequency distribution (TFD). Results of ongoing time-frequency (TF) research are presented. Based on our preliminary results, the first conditional moment of HRV which is the mean/central frequency in the LF band and the variance in the HF band can be used as a good feature to discriminate the newborn seizure from the nonseizure.

  14. Time-Frequency Analysis of Heart Rate Variability for Neonatal Seizure Detection

    Directory of Open Access Journals (Sweden)

    Boualem Boashash

    2007-01-01

    Full Text Available There are a number of automatic techniques available for detecting epileptic seizures using solely electroencephalogram (EEG, which has been the primary diagnosis tool in newborns. The electrocardiogram (ECG has been much neglected in automatic seizure detection. Changes in heart rate and ECG rhythm were previously linked to seizure in case of adult humans and animals. However, little is known about heart rate variability (HRV changes in human neonate during seizure. In this paper, we assess the suitability of HRV as a tool for seizure detection in newborns. The features of HRV in the low-frequency band (LF: 0.03–0.07 Hz, mid-frequency band (MF: 0.07–0.15 Hz, and high-frequency band (HF: 0.15–0.6 Hz have been obtained by means of the time-frequency distribution (TFD. Results of ongoing time-frequency (TF research are presented. Based on our preliminary results, the first conditional moment of HRV which is the mean/central frequency in the LF band and the variance in the HF band can be used as a good feature to discriminate the newborn seizure from the nonseizure.

  15. Toward an Integrated Rating Methodology for Corporate Risk Detection

    OpenAIRE

    Mantovani, Guido Max; Corò, Giancarlo; Gurisatti, Paolo; Mestroni, Mattia

    2014-01-01

    The need to innovate rating methodologies toward an integrated approach is crucial in the Italian financial contest. Currently, the banking system and the economic actors are unable to create effective and efficient information flows to react to the crisis. Banks weakness derives from the adopted rating models, which are mainly based on credit tendencies. They produce cyclical effects on credit availability and are not able to anticipate anticyclical firms’ trends. The separation between fina...

  16. Empirical evidence against the exchange rate anomaly: the Australian case

    Directory of Open Access Journals (Sweden)

    Luis A. Gil-Alana

    2006-06-01

    Full Text Available Though there is widespread agreement that the logarithmic spot and forward rates are both integrated of order one (I(1 variables, so that their corresponding returns are I(0 stationary, it has been recently claimed that they may be long memory. In this article, we examine this hypothesis by means of fractional integration techniques. The results based on parametric and semiparametric tests show that though fractional degrees of integration are plausible alternatives, the confidence intervals include the unit root case in both series. In addition, the hypothesis of unbiasedness of the forward rate as a forecaster for the future spot rate cannot be rejected for the Australian daily exchange rate market.Embora haja um acordo difundido de que o ponto logarítmico e as taxas para frente são ambas integradas de variáveis da ordem um (I(1, de modo que seus retornos correspondentes sejam I(0 estacionário, tem-se reivindicado recentemente que elas podem ser memória longa. Neste artigo, examinamos esta hipótese por meio do uso de técnicas fracionárias de integração. Os resultados baseados em testes paramétricos e semiparametricos mostram que embora os graus fracionários de integração sejam alternativas plausíveis, os intervalos de confiança incluem o caso da raiz unitária em ambas as séries. Além disso, a hipótese de não viés da taxa para frente como um preditor para a taxa a vista futura não pode ser rejeitada para o caso australiano.

  17. Crosstalk Cascades for Frame-rate Pedestrian Detection

    OpenAIRE

    Dollár, Piotr; Appel, Ron; Kienzle, Wolf

    2012-01-01

    Cascades help make sliding window object detection fast, nevertheless, computational demands remain prohibitive for numerous applications. Currently, evaluation of adjacent windows proceeds independently; this is suboptimal as detector responses at nearby locations and scales are correlated. We propose to exploit these correlations by tightly coupling detector evaluation of nearby windows. We introduce two opposing mechanisms: detector excitation of promising neighbors and inhibition of...

  18. Cardiac rate detection method based on the beam splitter prism

    Science.gov (United States)

    Yang, Lei; Liu, Xiaohua; Liu, Ming; Zhao, Yuejin; Dong, Liquan; Zhao, Ruirui; Jin, Xiaoli; Zhao, Jingsheng

    2013-09-01

    A new cardiac rate measurement method is proposed. Through the beam splitter prism, the common-path optical system of transmitting and receiving signals is achieved. By the focusing effect of the lens, the small amplitude motion artifact is inhibited and the signal-to-noise is improved. The cardiac rate is obtained based on the PhotoPlethysmoGraphy (PPG). We use LED as the light source and use photoelectric diode as the receiving tube. The LED and the photoelectric diode are on the different sides of the beam splitter prism and they form the optical system. The signal processing and display unit is composed by the signal processing circuit, data acquisition device and computer. The light emitted by the modulated LED is collimated by the lens and irradiates the measurement target through the beam splitter prism. The light reflected by the target is focused on the receiving tube through the beam splitter prism and another lens. The signal received by the photoelectric diode is processed by the analog circuit and obtained by the data acquisition device. Through the filtering and Fast Fourier Transform, the cardiac rate is achieved. We get the real time cardiac rate by the moving average method. We experiment with 30 volunteers, containing different genders and different ages. We compare the signals captured by this method to a conventional PPG signal captured concurrently from a finger. The results of the experiments are all relatively agreeable and the biggest deviation value is about 2bmp.

  19. Nuclear target effect on dark matter detection rate

    OpenAIRE

    Bednyakov, V. A.; Simkovic, F.

    2005-01-01

    Expected event rates for a number of dark matter nuclear targets were calculated in the effective low-energy minimal supersymmetric standard model, provided the lightest neutralino is the dark matter Weakly Interacting Massive Particle (WIMP). These calculations allow direct comparison of sensitivities of different dark matter detectors to intermediate mass WIMPs expected from the measurements of the DArk MAtter (DAMA) experiment.

  20. Metamorphic computer virus detection by Case- Based Reasoning (CBR) methods

    OpenAIRE

    Abdellatif Berkat

    2011-01-01

    Metamorphic virus employs code obfuscation techniques to mutate itself. It absconds from signaturebaseddetection system by modifying internal structure without compromising original functionality.In this paper, we propose a new method, for detecting metamorphic computer viruses, that is based on thetechnique of Case-Based Reasoning (CBR). In this method:-Can detect similar viruses with high probability.- The updating of the virus database is done automatically without connecting to the Intern...

  1. Detecting outliers in multivariate data while controlling false alarm rate

    Directory of Open Access Journals (Sweden)

    André Achim

    2012-06-01

    Full Text Available Outlier identification often implies inspecting each z-transformed variable and adding a Mahalanobis D^2. Multiple outliers may mask each other by increasing variance estimates. Caroni and Prescott (1992 proposed a multivariate extension of Rosner’s (1983 technique to circumvent masking, taking sample size into account to keep the false alarm risk below, say, alpha = .05. Simulations studies here compare the single multivariate approach to "multiple-univariate plus multivariate" tests, each at a Bonferroni corrected alpha level, in terms of power at detecting outliers. Results suggest the former is better only up to about 12 variables. Macros in an Excel spreadsheet implement these techniques.

  2. Using Case-Based Reasoning for detecting computer virus

    OpenAIRE

    Abdellatif Berkat

    2011-01-01

    The typical antivirus approach consists of waiting for a number of computers to be infected, detecting the virus, designing a solution, delivering and deploying a solution. In such a situation, it is very difficult to prevent every machine from being compromised by viruses. In this paper, we propose a new method, for detecting computer viruses, that is based on the technique of Case-Based Reasoning (CBR). In this method: (1) even new viruses that do not exist in the database can be detected (...

  3. Relationship of detection rate of PET cancer screening examinees and risk factors. Analysis of background of examinees

    International Nuclear Information System (INIS)

    Positron emission tomography (PET) cancer screening is performed widely in Japan as opportunistic screening, but no study has focused on the correlation with various cancer risk factors and the seeking bias of examinees and cancer detection rate. Analyzing our large series of PET cancer screening data, correlations with cancer detection rates according to general cancer risk factors and PET detection survey were reviewed, and the selection bias of the medical examinees was determined. 19189 examinees who underwent PET cancer screening were enrolled. Using logistic-regression analysis, we analyzed correlations between smoking history/drinking history/cancer family history and detection rates of thyroid cancer/breast cancer/colorectal cancer/lung cancer, which are the main malignancies detected in PET cancer screening. In addition, we evaluated seeking bias of examinees, analyzing correlations between the presence of cancer risk factors and prior screening checkups at other institutions to our PET cancer screening using a matched case-control study. Cancer detection rates by FDG-PET were 1.17% (224/19189), being much higher than those of standard cancer mass screenings. In males, statistically significant correlations were seen between lung cancer and smoking, and between prostate cancer and a family history of prostate cancer, but not between the detection rates of three other types of cancer (thyroid cancer/lung cancer/colorectal cancer) and other cancer risk factors. In females, detection rates of four types of cancer (thyroid cancer/lung cancer/colorectal cancer/breast cancer) were significantly higher in the examinees without cancer risks, and subgroup analysis according to types of cancer did not indicate significant correlations either. The matched case-control study evaluating seeking bias indicated that a significant proportion of the examinees with cancer risks had undergone prior cancer screening at other institutions. Our study indicated that there was

  4. Nominal effective exchange rate neutrality: the case of Macedonia

    OpenAIRE

    Josheski, Dushko; Lazarov, Darko

    2012-01-01

    urrently, the exchange rate regime in the Republic of Macedonia is what is refered to as a "managed float." The exchange rate of the denar is established on the basis of supply and demand of foreign exchange markets. The denar exchange rate against the euro serves as a fundamental of the Republic of Macedonia monetary policy. Money supply and interest rates are dictated by the exchange rate target. This paper uses Structural Vector Autoregression method to find empirical evidence ...

  5. PET-CT detection rate of primary breast cancer lesions. Correlation with the clinicopathological factors

    International Nuclear Information System (INIS)

    One hundred and forty lesions of primary breast cancer underwent positron emission tomography (PET)-CT between June 2006 and May 2007. The PET-CT detection rate of primary breast cancer lesions was 72.1%. The detection rate was 52.1% for invasive cancer ≤20 mm, 92.8% for invasive breast cancers >20 mm, and these results were significant. In the present study, no significant relationship was observed between tumor types, however, invasive lobular carcinoma showed a lower detection rate, 58.3%. The PET-CT results were not significantly affected by either estrogen and progesterone receptors or distant metastasis. A significant correlation regarding the detection rate of PET-CT was found with HER2 status, tumor grade, and axillary lymph node status. The detection rate was 100% for invasive cancer ≤20 mm when the interval between prior diagnostic Mammotome biopsies and PET-CT was less than 3 weeks, 18.8% for invasive cancer ≤20 mm when the interval was more than 3 weeks, and these results were significant. Mammotome biopsies may therefore affect the detection rate of PET-CT. Invasive cancers ≤20 mm showed a low detection rate, therefore, it is considered to be insufficient to use PET-CT for the detection of early breast cancer. (author)

  6. Using Case-Based Reasoning for detecting computer virus

    Directory of Open Access Journals (Sweden)

    Abdellatif Berkat

    2011-07-01

    Full Text Available The typical antivirus approach consists of waiting for a number of computers to be infected, detecting the virus, designing a solution, delivering and deploying a solution. In such a situation, it is very difficult to prevent every machine from being compromised by viruses. In this paper, we propose a new method, for detecting computer viruses, that is based on the technique of Case-Based Reasoning (CBR. In this method: (1 even new viruses that do not exist in the database can be detected (2 The updating of the virus database is done automatically without connecting to the Internet. Whenever a new virus is detected, it will be automatically added to the database used by our application. This presents a major advantage

  7. Provincial Variations in Divorce Rates: A Canadian Case.

    Science.gov (United States)

    Makabe, Tomoko

    1980-01-01

    Examines differentials in divorce rates in Canada. Provinces with higher population turnover are characterized by lower degrees of social integration and lower social costs attached to divorce, reflected in higher divorce rates. The hypothesis that divorce rates are higher where more economic opportunities are available for women is explored.…

  8. Detection rates of the MODIS active fire product in the United States

    Science.gov (United States)

    Hawbaker, T.J.; Radeloff, V.C.; Syphard, A.D.; Zhu, Z.; Stewart, S.I.

    2008-01-01

    MODIS active fire data offer new information about global fire patterns. However, uncertainties in detection rates can render satellite-derived fire statistics difficult to interpret. We evaluated the MODIS 1??km daily active fire product to quantify detection rates for both Terra and Aqua MODIS sensors, examined how cloud cover and fire size affected detection rates, and estimated how detection rates varied across the United States. MODIS active fire detections were compared to 361 reference fires (??? 18??ha) that had been delineated using pre- and post-fire Landsat imagery. Reference fires were considered detected if at least one MODIS active fire pixel occurred within 1??km of the edge of the fire. When active fire data from both Aqua and Terra were combined, 82% of all reference fires were found, but detection rates were less for Aqua and Terra individually (73% and 66% respectively). Fires not detected generally had more cloudy days, but not when the Aqua data were considered exclusively. MODIS detection rates decreased with fire size, and the size at which 50% of all fires were detected was 105??ha when combining Aqua and Terra (195??ha for Aqua and 334??ha for Terra alone). Across the United States, detection rates were greatest in the West, lower in the Great Plains, and lowest in the East. The MODIS active fire product captures large fires in the U.S. well, but may under-represent fires in areas with frequent cloud cover or rapidly burning, small, and low-intensity fires. We recommend that users of the MODIS active fire data perform individual validations to ensure that all relevant fires are included. ?? 2008 Elsevier Inc. All rights reserved.

  9. High rate of drug resistance among tuberculous meningitis cases in Shaanxi province, China.

    Science.gov (United States)

    Wang, Ting; Feng, Guo-Dong; Pang, Yu; Liu, Jia-Yun; Zhou, Yang; Yang, Yi-Ning; Dai, Wen; Zhang, Lin; Li, Qiao; Gao, Yu; Chen, Ping; Zhan, Li-Ping; Marais, Ben J; Zhao, Yan-Lin; Zhao, Gang

    2016-01-01

    The clinical and mycobacterial features of tuberculous meningitis (TBM) cases in China are not well described; especially in western provinces with poor tuberculosis control. We prospectively enrolled patients in whom TBM was considered in Shaanxi Province, northwestern China, over a 2-year period (September 2010 to December 2012). Cerebrospinal fluid specimens were cultured for Mycobacterium tuberculosis; with phenotypic and genotypic drug susceptibility testing (DST), as well as genotyping of all positive cultures. Among 350 patients included in the study, 27 (7.7%) had culture-confirmed TBM; 84 (24.0%) had probable and 239 (68.3%) had possible TBM. DST was performed on 25/27 (92.3%) culture positive specimens; 12/25 (48.0%) had "any resistance" detected and 3 (12.0%) were multi-drug resistant (MDR). Demographic and clinical features of drug resistant and drug susceptible TBM cases were similar. Beijing was the most common genotype (20/25; 80.0%) with 9/20 (45%) of the Beijing strains exhibiting drug resistance; including all 3 MDR strains. All (4/4) isoniazid resistant strains had mutations in the katG gene; 75% (3/4) of strains with phenotypic rifampicin resistance had mutations in the rpoB gene detected by Xpert MTB/RIF®. High rates of drug resistance were found among culture-confirmed TBM cases; most were Beijing strains. PMID:27143630

  10. 2007 Wholesale Power Rate Case Final Proposal : Wholesale Power Rate Development Study.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    2006-07-01

    The Wholesale Power Rate Development Study (WPRDS) serves two primary purposes. It synthesizes information supplied by the other final studies that comprise the BPA rate proposal and shows the actual calculations for BPA's power rates. In addition, the WPRDS is the primary source for certain information used in establishing the power rates. Information developed in the WPRDS includes rate design (including seasonal and diurnal shapes for energy rates, demand, and load variance rates), the risk mitigation tools (Cost Recovery Adjustment Clause (CRAC), along with the [N]ational Marine Fisheries Service [F]ederal Columbia River Power System [B]iological Opinion (NFB) Adjustment, the Emergency NFB Surcharge, and Dividend Distribution Clause (DDC)), development of the Slice rate, and all discounts and other adjustments that are included in the rate schedules and the General Rate Schedule Provisions. The WPRDS also includes the description of the methodology for the Cost of Service Analysis (COSA), and the various rate design steps necessary to establish BPA's power rates. The WPRDS also shows the calculations for inter-business line revenues and expenses, the revenue forecast and, finally, includes a description of all of the rate schedules. The actual rate schedules are shown in ''Administrator's Final Record of Decision (ROD), Appendix A: 2007 Wholesale Power Rate Schedules and General Rate Schedule Provisions, WP-07-A-02''. The WPRDS also includes the Partial Resolution of Issues, shown in Attachment 1 of the ROD. The Partial Resolution of Issues affected many of the features described in this study. These are noted where appropriate.

  11. Insights for Analyzing Earnings Growth Rates: A Case Study.

    Science.gov (United States)

    Hannah, Richard L.

    1994-01-01

    A study at one public university investigated the annualized rate of salary/wage increase of employees from the time of hiring until July 1992. It examined promotion patterns, equity adjustments, employee degree acquisition, and certification of clerical workers. The study underscored the wide variation in earnings growth rates due in large part…

  12. Incorporating a Time Horizon in Rate-of-Return Estimations: Discounted Cash Flow Model in Electric Transmission Rate Cases

    International Nuclear Information System (INIS)

    Electric transmission and other rate cases use a form of the discounted cash flow model with a single long-term growth rate to estimate rates of return on equity. It cannot incorporate information about the appropriate time horizon for which analysts' estimates of earnings growth have predictive powers. Only a non-constant growth model can explicitly recognize the importance of the time horizon in an ROE calculation. (author)

  13. Detection Rate and Clinical Impact of Respiratory Viruses in Children with Kawasaki Disease

    Directory of Open Access Journals (Sweden)

    Ja Hye Kim

    2012-12-01

    Full Text Available &lt;B&gt;Purpose:&lt;/B&gt; The purpose of this prospective case-control study was to survey the detection rate of respiratory viruses in children with Kawasaki disease (KD by using multiplex reverse transcriptasepolymerase chain reaction (RT-PCR, and to investigate the clinical implications of the prevalence of respiratory viruses during the acute phase of KD. &lt;B&gt;Methods:&lt;/B&gt; RT-PCR assays were carried out to screen for the presence of respiratory syncytial virus A and B, adenovirus, rhinovirus, parainfluenza viruses 1 to 4, influenza virus A and B, metapneumovirus, bocavirus, coronavirus OC43/229E and NL63, and enterovirus in nasopharyngeal secretions of 55 KD patients and 78 control subjects. &lt;B&gt;Results:&lt;/B&gt; Virus detection rates in KD patients and control subjects were 32.7% and 30.8%, respectively (P=0.811. However, there was no significant association between the presence of any of the 15 viruses and the incidence of KD. Comparisons between the 18 patients with positive RT-PCR results and the other 37 KD patients revealed no significant differences in terms of clinical findings (including the prevalence of incomplete presentation of the disease and coronary artery diameter. &lt;B&gt;Conclusion:&lt;/B&gt; A positive RT-PCR for currently epidemic respiratory viruses should not be used as an evidence against the diagnosis of KD. These viruses were not associated with the incomplete presentation of KD and coronary artery dilatation.

  14. The effects of pulse rate, power, width and coding on signal detectability

    Science.gov (United States)

    Carter, D. A.

    1983-01-01

    The effects on the signal detectability of varying the pulse repetition rate (PRF), peak pulse power (p(pk)) and pulse width (tau(p)) (tp) are examined. Both coded and uncoded pulses are considered. The following quantities are assumed to be constant; (1) antenna area, (z)echo reflectivity, (3) Doppler shift, (4) spectral width, (5) spectral resolution, (6) effective sampling rate, and (7) total incoherent spectral averagaing time. The detectability is computed for two types of targets.

  15. Exchange Rate Instability and Trade. The Case of Pakistan

    OpenAIRE

    M. Ali Kemal

    2005-01-01

    The variations in exchange rate play a vital role in the determination of trade balance. Volatile exchange rate shatters the investor’s and trader’s confidence, and slows down the process of trade, which results in slower growth. In this paper, other market instabilities—such as GDP growth instability in imports equation and agriculture and manufacturing instability in exports equation—have been used with exchange rate instability, and GARCH variance is used to measure it. It is found that th...

  16. Stock Returns and Interest Rates: The Case of Greece

    OpenAIRE

    Harissis, H.F.

    1999-01-01

    This paper examines the influence of interest rate changes on stocks’ returns for seven portfolios, which have been constructed from various industries of the Greek Economy. For that purpose we use the two–factors model. The present paper, using the Augmented Market Model, aims at analysing stock returns of those Greek Economy industries that are listed at the Athens Stock Exchange with reference to the interest rate changes.

  17. Government Spending and Real Exchange Rate Case of Albania

    Directory of Open Access Journals (Sweden)

    Edmira Cakrani

    2013-04-01

    Full Text Available Various studies have found that governmentspending can lead to overestimation orunderestimation of the real exchange rate, depending on the composition of theseexpenditures. The purpose of this paper is toassess the impact of government spendingon real exchange rate in Albania. In this paper is used a log liner model with quarterlydata. Other explanatory variables in this model are: foreign direct investment, remittances,real GDP per capita, openness. Variables are tested for unit root and cointegration. Theresults indicate that government spendingis associated with overvaluation of realexchange rate in Albania.JEL Classification: E62; F31Various studies have found that governmentspending can lead to overestimation orunderestimation of the real exchange rate, depending on the composition of theseexpenditures. The purpose of this paper is toassess the impact of government spendingon real exchange rate in Albania. In this paper is used a log liner model with quarterlydata. Other explanatory variables in this model are: foreign direct investment, remittances,real GDP per capita, openness. Variables are tested for unit root and cointegration. Theresults indicate that government spendingis associated with overvaluation of realexchange rate in Albania.JEL Classification: E62; F31

  18. A pilot study on low power pulse rate detection based on compressive sampling.

    Science.gov (United States)

    Huang, B Y; Wang, L; Wang, B; Lin, S J; Wu, D; Zhang, Y T

    2009-01-01

    Low power consumption is one of the key design challenges for various pervasive healthcare systems. Compressive Sampling (CS) is an emerging technique for reconstructing signals from data sampled under the Nyquist rate. CS has great potentials for low power pulse rate detection based on photoplethysmograph (PPG) signals, since by reducing the PPG data sampling rate the LEDs could be turned off for a prolonged period of time. Obviously the higher CS rate, the lower power consumption and lower pulse rate measurement accuracies. In this paper, a feasibility study of using CS for low power pulse rate detection was conducted. A miniature PPG measurement device based on our body sensor networks platform was employed for signal acquisition. Experiments for evaluation the pulse rate estimation and the power consumption were completed. Results suggested that the Gradient Projection for Sparse Reconstruction (GPSR) algorithm is a highly efficient for retrieving pulse rate from PPG signals. It was suggested that the CS rate should be approximate 3 for low power pulse rate detections with averaging estimation mean-square error being less than 5. PMID:19963730

  19. On comparison of jump point detection for an exchange rate series

    Institute of Scientific and Technical Information of China (English)

    IP Wai-Cheung; WONG Heung; XIE Zhongjie; LUAN Yihui

    2004-01-01

    The main purpose of this paper is to investigate the detection of jump points of a discontinuous function in the presence of a noise by the wavelet approach. A computing algorithm of our method is proposed and then applied to the daily exchange rate of US Dollar against Deutsche Mark. All the points detected by our method reflect very strong economic and political impacts. Other statistical methods to detect jump points have also been applied to the same exchange rate data. Our proposed method has produced more convincing empirical results than others.

  20. EXCHANGE RATE AND ECONOMIC GROWTH. THE CASE OF ROMANIA

    Directory of Open Access Journals (Sweden)

    Nicolae Ghiba

    2010-12-01

    Full Text Available Considering the difficulties created by the economic crisis, many exporters have criticized the National Bank of Romania (NBR’s policy regarding the exchange rate evolution. They argue that depreciation is a necessary condition for recovery and not financial stability. On the contrary, Romania cannot afford a shock in the exchange rate level. The risk associated with such a measure is too high for an emerging country and it annihilates any export competitive advantages. Therefore, depreciation may delay the imperative of Romanian economic recovery. A solid economic recovery should have as starting point a financial system sound and stable. Excessive exchange rate depreciation jeopardizes the financial soundness of banks and the borrower’s ability to repay their loans. Therefore, it creates inflationary flare-ups, particularly dangerous for the economy of any state.

  1. A Novel Microfluidic Flow Rate Detection Method Based on Surface Plasmon Resonance Temperature Imaging.

    Science.gov (United States)

    Deng, Shijie; Wang, Peng; Liu, Shengnan; Zhao, Tianze; Xu, Shanzhi; Guo, Mingjiang; Yu, Xinglong

    2016-01-01

    A novel microfluidic flow rate detection method based on surface plasmon resonance (SPR) temperature imaging is proposed. The measurement is performed by space-resolved SPR imaging of the flow induced temperature variations. Theoretical simulations and analysis were performed to demonstrate a proof of concept using this approach. Experiments were implemented and results showed that water flow rates within a wide range of tens to hundreds of μL/min could be detected. The flow rate sensor is resistant to disturbances and can be easily integrated into microfluidic lab-on-chip systems. PMID:27347960

  2. Correct Interpretation of Creep Rates: A Case Study of Cu

    Czech Academy of Sciences Publication Activity Database

    Blum, W.; Dvořák, Jiří; Král, Petr; Eisenlohr, P.; Sklenička, V.

    2015-01-01

    Roč. 31, č. 11 (2015), s. 1065-1068. ISSN 1005-0302 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0068 Institutional support: RVO:68081723 Keywords : Cu * Creep * Minimum creep rate * Activation energy * Stress exponent Subject RIV: JJ - Other Materials Impact factor: 1.909, year: 2014

  3. Cross-sectional survey of detectable rate of subclinical hypothyroidism in different people in China

    International Nuclear Information System (INIS)

    Objective: To investigate the detectable rates of subclinical hypothyroidism (SH) of children aged 8-10 years, adults aged 18-45 years, breast feeding women and pregnant women, and analyze the differences of the detectable rates in different people with different levels of urinary iodine concentrations and immune status in order to provide new indexes for prevention and treatment of iodine deficiency disorders. Methods: A cross-sectional survey was performed in four kinds of 1999 target people (633 children aged 8-10 years, 703 adults aged 18-45 years, 334 breast feeding women and 329 pregnant women) in six different areas in China from the April 2009 to April 2010. The morning blood samples and three urine samples selected randomly of different people were collected and the thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid microsome antibody (TMAb), thyroid globulin antibody (TGAb) in blood samples and iodine in urine samples were detected. Results: The detectable rates of subclinical hypothyroidism of children aged -10 years old, adults aged 18-45 years old, breast feeding women and pregnant women were 10.43% , 4.84% , 4.19% , and 3.95% , respectively. The detectable rate of SH in children group was significantly higher than that in adults group (P<0.01). There was no significant differences of the detectable rates of SH between children children whose urinary iodine were normal and children whose urinary iodine were elevated (P>0.05). The positive rates of TMAb and TGAb of people with SH were significantly higher than those of people with normal thyroid function (P<0.01). Conclusion: The detectable rate of SH of children aged 8-10 years is higher than those in other three groups, which indicates that the index of SH should be used in routine monitoring of iodine disorder control in children. (authors)

  4. Exchange Rate Exposure and Exchange Rate Risk Management: The case of Japanese exporting firms

    OpenAIRE

    Ito, Takatoshi; KOIBUCHI Satoshi; SATO Kiyotaka; SHIMIZU Junko

    2013-01-01

    In this paper, we estimate Japanese firms' exchange rate exposure and investigate the impact of exchange rate risk management on them. By using the results of the questionnaire survey sent to all Tokyo Stock Exchange listed firms in 2009, we conduct empirical analysis to investigate whether each risk management tool—financial and operational hedging, the choice of invoice currency, and the price revision strategy (pass-through)—specifically affects their foreign exchange exposure. As a result...

  5. Coalescence Rate of Supermassive Black Hole Binaries Derived from Cosmological Simulations: Detection Rates for LISA and ET

    CERN Document Server

    Filloux, Ch; Durier, F; de Araujo, J C N

    2011-01-01

    The coalescence history of massive black holes has been derived from cosmological simulations, in which the evolution of those objects and that of the host galaxies are followed in a consistent way. The present study indicates that supermassive black holes having masses greater than $\\sim 10^{9} M_{\\odot}$ underwent up to 500 merger events along their history. The derived coalescence rate per comoving volume and per mass interval permitted to obtain an estimate of the expected detection rate distribution of gravitational wave signals ("ring-down") along frequencies accessible by the planned interferometers either in space (LISA) or in the ground (Einstein). For LISA, in its original configuration, a total detection rate of about $15 yr^{-1}$ is predicted for events having a signal-to-noise ratio equal to 10, expected to occur mainly in the frequency range $4-9 mHz$. For the Einstein gravitational wave telescope, one event each 14 months down to one event each 4 years is expected with a signal-to-noise ratio o...

  6. Fluorescence in situ hybridization in uncultured amniocytes for detection of aneuploidy in 4210 prenatal cases

    Institute of Scientific and Technical Information of China (English)

    JIA Chan-wei; WANG Shu-yu; MA Yan-min; LAN Yong-lian; SI Yan-mei; YU Lan; ZHOU Li-ying

    2011-01-01

    Background Almost all reported fluorescence in situ hybridization (FISH) kits for prenatal diagnosis use probes from foreign (non-Chinese) countries. The aim of this study was to analyze the reliability of domestic (Chinese) FISH probe sets to detect aneuploidies of chromosomes 13, 18, 21, X, and Y related to prenatal diagnosis in 4210 cases.Methods Cytogenetic karyotyping was carded out as a standard prenatal diagnostic test, and amniotic fluid cell interphase FISH analysis was performed using two sets of probes (centromeric probes for chromosomes 18, X, and Y,and locus-specific probes for chromosomes 13 and 21) provided by GP Medical Technologies, Beijing, China. Then we compared the two results and found the performance characteristics for informative FISH results of aneuploidies by the domestic kit probes.Results In 4210 cases, 4126 cases generated karyotype results and 133 abnormal karyotypes (including 97 aneuploidies) were found. The FISH results of 98 cases (among them, 31 cases gave normal cytogenetic results) were uninformative. The rate of abnormal cases was 3.2% (133/4126). For the abnormal karyotypes, the rate of aneuploidy was 72.9% (97/133). Among the 97 aneuploidies, there were 58 cases of trisomy 21 (58/97, 59.8%), four cases of trisomy 13, 23 cases of trisomy 18, and 12 cases of sex chromosomal aneuploidies. The total concordance of the two methods was 97.9% (95/97; two cases were mosaics that had a low percentage of abnormal cells), and the concordance of trisomy 21, 13, and 18 by the two methods was 100%.Conclusions The two sets of the domestic FISH kit probes are reliable for prenatal diagnosis. The results demonstrate that FISH is a rapid and accurate clinical method for prenatal identification of chromosome aneuploidies.

  7. Link Between RI-ISI and Inspection Qualification: Relationship between Defect Detection Rate and Margin of Detection

    International Nuclear Information System (INIS)

    Quantitative risk-informed in-service inspection (RI-ISI) requires a quantitative measurement of inspection effectiveness if the risk change associated with an inspection is to be determined. Knowing the probability of detection (POD) as a function of defect depth (through wall dimension) would provide ideal information. However the main in-service inspection method for nuclear plant is ultrasonics, for which defect detection capability depends on a wide variety of parameters besides defect depth, such as defect orientation, roughness, location, shape etc. In recognition of this the European approach to inspection qualification is generally based on some combination of technical justification, and practical trials on a relatively limited number of defects. This inspection qualification process involves demonstrating that defects of concern will generate responses in excess of the specified recording level or noise, depending on the inspection. It is not currently designed to quantify the probability with which defects will be detected. The work described in this report has been performed in order to help address the problem of how the information generated during inspection qualification can be used as an input for RI-ISI. The approach adopted has been to recognise that as the defect response increases above the recording or noise level, the probability of detecting defects is likely to increase. The work therefore involved an investigation of the relationship between POD (strictly speaking defect detection rate) and margin of detection. It involved blind manual and automated ultrasonic trials on artificial defects in test plates designed to generate a range of signal responses. The detection rate for defects which provided signals at a particular level above noise or above a recording level was then measured. A relationship between defect detection rate and margin of detection has been established based on these trials. In addition to establishing a stronger link

  8. The Case for an M2 Growth Rate of 10%

    OpenAIRE

    William Carlson; Conway Lackman

    2013-01-01

    The recovery from the 2008-2009 recession has been much slower than the average recovery since the 1924 recession. As analysts who believe that the St. Louis model created by Leonall Andersen and Jerry Jordan still has relevance we believe that the slow rate of M2 growth since 2Q2009 is a major reason why GDP growth has been so slow. At the 9th Annual Missouri Economics Conference on March 27, 2009 we presented a paper, “Interwar Hoarding, Liquidity Traps, and the 2008 Solvency Trap” in whic...

  9. LASER: A Maximum Likelihood Toolkit for Detecting Temporal Shifts in Diversification Rates From Molecular Phylogenies

    Directory of Open Access Journals (Sweden)

    Daniel L. Rabosky

    2006-01-01

    Full Text Available Rates of species origination and extinction can vary over time during evolutionary radiations, and it is possible to reconstruct the history of diversification using molecular phylogenies of extant taxa only. Maximum likelihood methods provide a useful framework for inferring temporal variation in diversification rates. LASER is a package for the R programming environment that implements maximum likelihood methods based on the birth-death process to test whether diversification rates have changed over time. LASER contrasts the likelihood of phylogenetic data under models where diversification rates have changed over time to alternative models where rates have remained constant over time. Major strengths of the package include the ability to detect temporal increases in diversification rates and the inference of diversification parameters under multiple rate-variable models of diversification. The program and associated documentation are freely available from the R package archive at http://cran.r-project.org.

  10. Using the nucleotide substitution rate matrix to detect horizontal gene transfer

    Directory of Open Access Journals (Sweden)

    Betterton M D

    2006-10-01

    Full Text Available Abstract Background Horizontal gene transfer (HGT has allowed bacteria to evolve many new capabilities. Because transferred genes perform many medically important functions, such as conferring antibiotic resistance, improved detection of horizontally transferred genes from sequence data would be an important advance. Existing sequence-based methods for detecting HGT focus on changes in nucleotide composition or on differences between gene and genome phylogenies; these methods have high error rates. Results First, we introduce a new class of methods for detecting HGT based on the changes in nucleotide substitution rates that occur when a gene is transferred to a new organism. Our new methods discriminate simulated HGT events with an error rate up to 10 times lower than does GC content. Use of models that are not time-reversible is crucial for detecting HGT. Second, we show that using combinations of multiple predictors of HGT offers substantial improvements over using any single predictor, yielding as much as a factor of 18 improvement in performance (a maximum reduction in error rate from 38% to about 3%. Multiple predictors were combined by using the random forests machine learning algorithm to identify optimal classifiers that separate HGT from non-HGT trees. Conclusion The new class of HGT-detection methods introduced here combines advantages of phylogenetic and compositional HGT-detection techniques. These new techniques offer order-of-magnitude improvements over compositional methods because they are better able to discriminate HGT from non-HGT trees under a wide range of simulated conditions. We also found that combining multiple measures of HGT is essential for detecting a wide range of HGT events. These novel indicators of horizontal transfer will be widely useful in detecting HGT events linked to the evolution of important bacterial traits, such as antibiotic resistance and pathogenicity.

  11. Trends in detection of new leprosy cases at two centres in Himachal Pradesh, India: a ten-year study.

    Science.gov (United States)

    Mahajan, V K; Sharma, N L; Rana, P; Sood, N

    2003-01-01

    An impressive decline in leprosy prevalence rate (PR) in all endemic districts of India is seen in the post-MDT era. However, the new case-detection rate, an important statistical indicator in leprosy control programmes, has not shown significant decline in spite of all efforts. In Himachal Pradesh, a decline in PR from 7.8 to 0.56/10000 between 1991 to 2000 is seen, and recently the State has won national acclaim for having achieved the goal of elimination of leprosy in all the districts. The vertical leprosy programme has been integrated into general health services of the state. An analysis of data from 1991 to 2000 of two leprosy control units of Himachal Pradesh, the Urban Leprosy Clinic in Shimla (ULC-S) and the District Leprosy Control Unit in Mandi (DLCU-M), showed no significant decline in the new cases detected. 277 and 271 new cases were detected at these centres respectively; these included 2.2% and 1.5% children of less than 14 years of age. Almost 75% of these cases were males and of MB type. A steadily increasing trend in the annual detection of new cases was seen at both the centres during the decade. The cases registered at DLCU-M were mainly indigenous to the district. At ULC-S, 45 migrant cases from other endemic areas-mainly from Nepal, Bihar, and Uttar Pradesh-had also contributed to the increased number of new cases. Other possible causes discussed for this higher new case detection, e.g. overdiagnosis, detection of backlog "hidden cases" and voluntary reporting of patients, do not differ from those seen in other parts of the country or the world. PMID:15253391

  12. Bathtub-Shaped Failure Rate of Sensors for Distributed Detection and Fusion

    OpenAIRE

    Junhai Luo; Tao Li

    2014-01-01

    We study distributed detection and fusion in sensor networks with bathtub-shaped failure (BSF) rate of the sensors which may or not send data to the Fusion Center (FC). The reliability of semiconductor devices is usually represented by the failure rate curve (called the “bathtub curve”), which can be divided into the three following regions: initial failure period, random failure period, and wear-out failure period. Considering the possibility of the failed sensors which still work but in a ...

  13. Heart Rate Characteristics: Physiomarkers for Detection of Late-Onset Neonatal Sepsis

    OpenAIRE

    Fairchild, Karen D.; O'Shea, T. Michael

    2010-01-01

    Early detection of late onset neonatal sepsis, prior to obvious and potentially catastrophic clinical signs, is an important goal in neonatal medicine. Sepsis causes a well-known series of physiologic changes including abnormalities of blood pressure, respiration, temperature, and heart rate, and less well-known changes in heart rate variability. While vital signs are frequently or continuously monitored in NICU patients, changes in these parameters are subtle in the early phase of sepsis and...

  14. Rates of upgrade to malignancy for 271 cases of flat epithelial atypia (FEA) diagnosed by breast core biopsy.

    Science.gov (United States)

    Peres, Alexandre; Barranger, Emmanuel; Becette, Véronique; Boudinet, Alain; Guinebretiere, Jean-Marc; Cherel, Pascal

    2012-06-01

    Flat epithelial atypia (FEA) is a borderline lesion that might represent an early stage in the development of certain low-grade carcinomas in situ and invasive cancers. There are no guidelines on its management. Our objectives were to determine the upgrade to malignancy rate and identify a subpopulation of patients that might undergo just mammographic surveillance. We retrospectively reviewed the data for 271 FEA cases among 5,555 breast core biopsies obtained over a 7-year period (January 2003-2010). We collated clinical data (age, history of cancer, menopausal status), radiological data (lesion type, size, Bi-Rads category), technical data (number of biopsies, needle gauge, excision quality) and histological data and sought correlations between these factors and upgrade rate. The 271 FEA comprised 128 cases of pure FEA, 135 cases of FEA + atypical ductal hyperplasia, and 8 cases of FEA + atypical lobular hyperplasia. Overall, 184 patients underwent surgery and 46 mammographic surveillance. Surgery detected 34 cases of malignancy (23 CIS, 7 invasive cancers, and 4 mixed cases) giving a 15% upgrade rate. Quality of excision was the only factor associated with under-diagnosis. The presence of FEA at biopsy warrants surgery. PMID:22042365

  15. Impact of ASHA training on active case detection of visceral leishmaniasis in Bihar, India.

    Directory of Open Access Journals (Sweden)

    Vidya Nand Ravi Das

    2014-05-01

    Full Text Available BACKGROUND: One of the major challenges for management of visceral leishmaniasis (VL is early diagnosis of cases to improve treatment outcome and reduce transmission. We have therefore investigated active case detection of VL with the help of accredited social health activists (ASHA. ASHAs are women who live in the community and receive performance-based incentives for overseeing maternal and other health-related issues in their village. METHODS AND PRINCIPAL FINDING: Through conducting interviews with 400 randomly selected ASHAs from four primary health care centers (PHCs, it was observed that their level of knowledge about visceral leishmaniasis (VL regarding transmission, diagnosis, and treatment was limited. The baseline data indicated that less than 10% of VL cases seeking treatment at the PHCs were referred by ASHAs. To increase the knowledge and the referral rate of VL cases by ASHAs, training sessions were carried out during the monthly ASHA meetings at their respective PHCs. Following a single training session, the referral rate increased from less than 10% to over 27% and the overall knowledge about VL substantially improved. It was not possible, however, to demonstrate that ASHA training reduced the time that individuals had fever before treatment at the PHC. CONCLUSIONS: Training ASHAs to identify VL cases in villages for early diagnosis and treatment at the local PHC is feasible and should be undertaken routinely to improve knowledge about VL.

  16. High repetition rate laser-induced breakdown spectroscopy using acousto-optically gated detection

    Science.gov (United States)

    Pořízka, Pavel; Klessen, Benjamin; Kaiser, Jozef; Gornushkin, Igor; Panne, Ulrich; Riedel, Jens

    2014-07-01

    This contribution introduces a new type of setup for fast sample analysis using laser-induced breakdown spectroscopy (LIBS). The novel design combines a high repetition rate laser (up to 50 kHz) as excitation source and an acousto-optical modulator (AOM) as a fast switch for temporally gating the detection of the emitted light. The plasma radiation is led through the active medium of the AOM where it is diffracted on the transient ultrasonic Bragg grid. The diffracted radiation is detected by a compact Czerny-Turner spectrometer equipped with a CCD line detector. Utilizing the new combination of high repetition rate lasers and AOM gated detection, rapid measurements with total integration times of only 10 ms resulted in a limit of detection (LOD) of 0.13 wt.% for magnesium in aluminum alloys. This short integration time corresponds to 100 analyses/s. Temporal gating of LIP radiation results in improved LODs and consecutively higher sensitivity of the LIBS setup. Therefore, an AOM could be beneficially utilized to temporally detect plasmas induced by high repetition rate lasers. The AOM in combination with miniaturized Czerny-Turner spectrometers equipped with CCD line detectors and small footprint diode pumped solid state lasers results in temporally gateable compact LIBS setups.

  17. Detection and Modeling of Non-Tidal Oceanic Effects on the Earth's Rotation Rate

    Science.gov (United States)

    Marcus, S. L.; Chao, Y.; Dickey, J. O.; Gegout, P.

    1998-01-01

    Sub-decadal changes in the Earth's rotation rate, and hence in the length-of-day (LOD), are largely controlled by variations in atmospheric angular momentum. Results from two oceanic general circulation models (OGCMs), forced by observed wind stress and heat flux for the years 1992-1994, show that ocean current and mass distribution changes also induce detectable LOD variations.

  18. ECG signal analysis for detection of Heart Rate and Ischemic Episodes

    OpenAIRE

    Goutam Kumar Sahoo, Samit Ari, Sarat Kumar Patra

    2013-01-01

    Electrocardiogram (ECG) is generally used fordiagnosis ofcardiovascularabnormalitiesanddisorders.Anefficient method for analysingtheECG signal towards the detection ofheartrate(HR)andischemic episodesfollows mainly fivestages:pre-processing, feature extraction,heart ratedetection,beat classification and ischemicepisoderecognition.Theheart rate is calculatedusing theextracted featuresoftheECG signal. Thecalculated HRvaluecan beanalysedforthedetectionofvariouscardiovascularabnormalities.Theabil...

  19. A halo-independent lower bound on the dark matter capture rate in the Sun from a direct detection signal

    International Nuclear Information System (INIS)

    We show that a positive signal in a dark matter (DM) direct detection experiment can be used to place a lower bound on the DM capture rate in the Sun, independent of the DM halo. For a given particle physics model and DM mass we obtain a lower bound on the capture rate independent of the local DM density, velocity distribution, galactic escape velocity, as well as the scattering cross section. We illustrate this lower bound on the capture rate by assuming that upcoming direct detection experiments will soon obtain a significant signal. When comparing the lower bound on the capture rate with limits on the high-energy neutrino flux from the Sun from neutrino telescopes, we can place upper limits on the branching fraction of DM annihilation channels leading to neutrinos. With current data from IceCube and Super-Kamiokande non-trivial limits can be obtained for spin-dependent interactions and direct annihilations into neutrinos. In some cases also annihilations into ττ or bb start getting constrained. For spin-independent interactions current constraints are weak, but they may become interesting for data from future neutrino telescopes

  20. Real-time, low-complexity, low-memory solution to ECG-based heart rate detection.

    Science.gov (United States)

    Ravindran, Sourabh; Dunbar, Steven; Nisarga, Bhargavi

    2009-01-01

    This paper addresses the issue of heart rate detection from noisy ECG data, and presents a method with low complexity and low memory requirements that can detect QRS complex in the presence of noise and muscle artifacts. On the MIT-BIH arrhythmia database we were able to detect 99.3% of QRS complexes with 0.47% false detection. This method can also be applied to heart rate detection using phonocardio signals. PMID:19964757

  1. Reducing sojourn points from recurrence plots to improve transition detection: Application to fetal heart rate transitions.

    Science.gov (United States)

    Zaylaa, Amira; Charara, Jamal; Girault, Jean-Marc

    2015-08-01

    The analysis of biomedical signals demonstrating complexity through recurrence plots is challenging. Quantification of recurrences is often biased by sojourn points that hide dynamic transitions. To overcome this problem, time series have previously been embedded at high dimensions. However, no one has quantified the elimination of sojourn points and rate of detection, nor the enhancement of transition detection has been investigated. This paper reports our on-going efforts to improve the detection of dynamic transitions from logistic maps and fetal hearts by reducing sojourn points. Three signal-based recurrence plots were developed, i.e. embedded with specific settings, derivative-based and m-time pattern. Determinism, cross-determinism and percentage of reduced sojourn points were computed to detect transitions. For logistic maps, an increase of 50% and 34.3% in sensitivity of detection over alternatives was achieved by m-time pattern and embedded recurrence plots with specific settings, respectively, and with a 100% specificity. For fetal heart rates, embedded recurrence plots with specific settings provided the best performance, followed by derivative-based recurrence plot, then unembedded recurrence plot using the determinism parameter. The relative errors between healthy and distressed fetuses were 153%, 95% and 91%. More than 50% of sojourn points were eliminated, allowing better detection of heart transitions triggered by gaseous exchange factors. This could be significant in improving the diagnosis of fetal state. PMID:25308517

  2. Case-control comparison of bacterial and protozoan microorganisms associated with gastroenteritis: application of molecular detection.

    Science.gov (United States)

    Bruijnesteijn van Coppenraet, L E S; Dullaert-de Boer, M; Ruijs, G J H M; van der Reijden, W A; van der Zanden, A G M; Weel, J F L; Schuurs, T A

    2015-06-01

    The introduction of molecular detection of infectious organisms has led to increased numbers of positive findings, as observed for pathogens causing gastroenteritis (GE). However, because little is known about the prevalence of these pathogens in the healthy asymptomatic population, the clinical value of these additional findings is unclear. A case-control study was carried out in a population of patients served by general practitioners in the Netherlands. A total of 2710 fecal samples from case and matched control subjects were subjected to multiplex real-time PCR for the 11 most common bacterial and four protozoal causes of GE. Of 1515 case samples, 818 (54%) were positive for one or more target organisms. A total of 49% of the controls were positive. Higher positivity rates in cases compared to controls were observed for Campylobacter spp., Salmonella spp., Clostridium difficile, enteroinvasive Escherichia coli/Shigella spp., enterotoxigenic E. coli, enteroaggregative E. coli, atypical enteropathogenic E. coli (EPEC), Cryptosporidium parvum/hominis, and Giardia lamblia. However, Dientamoeba fragilis and Shiga-like toxigenic E. coli were detected significantly less frequent in cases than in controls, while no difference in prevalence was found for typical EPEC and enterohemorrhagic E. coli. The association between the presence of microorganisms and GE was the weakest in children aged 0 to 5 years. Higher relative loads in cases further support causality. This was seen for Campylobacter spp., Salmonella spp., enterotoxigenic E. coli, and C. parvum/hominis, and for certain age categories of those infected with C. difficile, enteroaggregative E. coli, and atypical EPEC. For D. fragilis and Shiga-like toxigenic E. coli/enterohemorrhagic E. coli, pathogen loads were lower in cases. Application of molecular diagnostics in GE is rapid, sensitive and specific, but results should be interpreted with care, using clinical and additional background information. PMID:25700890

  3. Real-time remote detection and measurement for airborne imaging spectroscopy: a case study with methane

    Directory of Open Access Journals (Sweden)

    D. R. Thompson

    2015-06-01

    Full Text Available Localized anthropogenic sources of atmospheric CH4 are highly uncertain and temporally variable. Airborne remote measurement is an effective method to detect and quantify these emissions. In a campaign context, the science yield can be dramatically increased by real-time retrievals that allow operators to coordinate multiple measurements of the most active areas. This can improve science outcomes for both single- and multiple-platform missions. We describe a case study of the NASA/ESA CO2 and Methane Experiment (COMEX campaign in California during June and August/September 2014. COMEX was a multi-platform campaign to measure CH4 plumes released from anthropogenic sources including oil and gas infrastructure. We discuss principles for real-time spectral signature detection and measurement, and report performance on the NASA Next Generation Airborne Visible Infrared Spectrometer (AVIRIS-NG. AVIRIS-NG successfully detected CH4 plumes in real-time at Gb s−1 data rates, characterizing fugitive releases in concert with other in situ and remote instruments. The teams used these real-time CH4 detections to coordinate measurements across multiple platforms, including airborne in situ, airborne non-imaging remote sensing, and ground-based in situ instruments. To our knowledge this is the first reported use of real-time trace gas signature detection in an airborne science campaign, and presages many future applications.

  4. Detecting rare variants in case-parents association studies.

    Directory of Open Access Journals (Sweden)

    Kuang-Fu Cheng

    Full Text Available Despite the success of genome-wide association studies (GWASs in detecting common variants (minor allele frequency ≥0.05 many suggested that rare variants also contribute to the genetic architecture of diseases. Recently, researchers demonstrated that rare variants can show a strong stratification which may not be corrected by using existing methods. In this paper, we focus on a case-parents study and consider methods for testing group-wise association between multiple rare (and common variants in a gene region and a disease. All tests depend on the numbers of transmitted mutant alleles from parents to their diseased children across variants and hence they are robust to the effect of population stratification. We use extensive simulation studies to compare the performance of four competing tests: the largest single-variant transmission disequilibrium test (TDT, multivariable test, combined TDT, and a likelihood ratio test based on a random-effects model. We find that the likelihood ratio test is most powerful in a wide range of settings and there is no negative impact to its power performance when common variants are also included in the analysis. If deleterious and protective variants are simultaneously analyzed, the likelihood ratio test was generally insensitive to the effect directionality, unless the effects are extremely inconsistent in one direction.

  5. Measurement of the modification and interference rate of urinary albumin detected by size-exclusion HPLC

    International Nuclear Information System (INIS)

    The measurement of the excretion of urinary albumin (albuminuria) is an important and well-established method to assess clinical outcomes. A high-performance liquid chromatography (HPLC) method has been introduced to measure albuminuria. Using this method, it was found that commonly used immunological methods do not measure a fraction of urinary albumin. Some authors presumed that the reason of immuno-unreactivity is the modification of urinary albumin; some others presumed that the difference is merely because of interference. In order to decide this question, we established an HPLC method equipped with tandem UV and fluorescent detection to assess the changes in the detectability of albumin with the rate of modification. For this measurement, differently modified forms of albumin were used. Urine samples of diabetic patients were also measured to find a potential connection between the modification rate and clinical parameters. Secondly, we have established a reversed phase HPLC method to assess the interference rate. We conclude that albumin modification does not affect immunoreactivity. The modification rate of urinary albumin in diabetic patients showed a correlation with renal function. The interference rate of the albumin peak was found to be 12.7% on average, which does not explain the difference between the two methods

  6. Stochastic optimization for the detection of changes in maternal heart rate kinetics during pregnancy

    Science.gov (United States)

    Zakynthinaki, M. S.; Barakat, R. O.; Cordente Martínez, C. A.; Sampedro Molinuevo, J.

    2011-03-01

    The stochastic optimization method ALOPEX IV has been successfully applied to the problem of detecting possible changes in the maternal heart rate kinetics during pregnancy. For this reason, maternal heart rate data were recorded before, during and after gestation, during sessions of exercises of constant mild intensity; ALOPEX IV stochastic optimization was used to calculate the parameter values that optimally fit a dynamical systems model to the experimental data. The results not only demonstrate the effectiveness of ALOPEX IV stochastic optimization, but also have important implications in the area of exercise physiology, as they reveal important changes in the maternal cardiovascular dynamics, as a result of pregnancy.

  7. The Diurnal Variation of the Wimp Detection Event Rates in Directional Experiments

    CERN Document Server

    Vergados, J D

    2009-01-01

    The recent WMAP data have confirmed that exotic dark matter together with the vacuum energy (cosmological constant) dominate in the flat Universe. Modern particle theories naturally provide viable cold dark matter candidates with masses in the GeV-TeV region. Supersymmetry provides the lightest supersymmetric particle (LSP), theories in extra dimensions supply the lightest Kaluza-Klein particle (LKP) etc. The nature of dark matter can only be unraveled only by its direct detection in the laboratory. All such candidates will be called WIMPs (Weakly Interacting Massive Particles). In any case the direct dark matter search, which amounts to detecting the recoiling nucleus, following its collision with WIMP, is central to particle physics and cosmology. In this work we briefly review the theoretical elements relevant to the direct dark matter detection experiments, paying particular attention to directional experiments. i.e experiments in which, not only the energy but the direction of the recoiling nucleus is ob...

  8. Luminance level of a monitor: influence on detectability and detection rate of breast cancer in 2D mammography

    Science.gov (United States)

    Bemelmans, Frédéric; Rashidnasab, Alaleh; Chesterman, Frédérique; Kimpe, Tom; Bosmans, Hilde

    2016-03-01

    Purpose: To evaluate lesion detectability and reading time as a function of luminance level of the monitor. Material and Methods: 3D mass models and microcalcification clusters were simulated into ROIs of for processing mammograms. Randomly selected ROIs were subdivided in three groups according to their background glandularity: high (>30%), medium (15-30%) and low (<15%). 6 non-spiculated masses (9 - 11mm), 6 spiculated masses (5 - 7mm) and 6 microcalcification clusters (2 - 4mm) were scaled in 3D to create a range of sizes. The linear attenuation coefficient (AC) of the masses was adjusted from 100% glandular tissue to 90%, 80%, 70%, to create different contrasts. Six physicists read the full database on Barco's Coronis Uniti monitor for four different luminance levels (300, 800, 1000 and 1200 Cd/m2), using a 4-AFC tool. Percentage correct (PC) and time were computed for all different conditions. A paired t-test was performed to evaluate the effect of luminance on PC and time. A multi-factorial analysis was performed using MANOVA.. Results: Paired t-test indicated a statistically significant difference for the average time per session between 300 and 1200; 800 and 1200; 1000 and 1200 Cd/m2, for all participants combined. There was no effect on PC. MANOVA denoted significantly lower reading times for high glandularity images at 1200 Cd/m2. Both types of masses were significantly faster detected at 1200 Cd/m2, for the contrast study. In the size study, microcalcification clusters and spiculated masses had a significantly higher detection rate at 1200 Cd/m2. Conclusion: These results demonstrate a significant decrease in reading time, while detectability remained constant.

  9. Nonlinear Detection for a High Rate Extended Binary Phase Shift Keying System

    OpenAIRE

    Le-Nan Wu; Xian-Qing Chen

    2013-01-01

    The algorithm and the results of a nonlinear detector using a machine learning technique called support vector machine (SVM) on an efficient modulation system with high data rate and low energy consumption is presented in this paper. Simulation results showed that the performance achieved by the SVM detector is comparable to that of a conventional threshold decision (TD) detector. The two detectors detect the received signals together with the special impacting filter (SIF) that can improve t...

  10. Independence of stimulus discriminability from absolute rate of reinforcement in a signal-detection procedure.

    OpenAIRE

    McCarthy, D; Davison, M.

    1982-01-01

    Three experiments are reported in which two pigeons were trained to detect differences in stimulus duration under varying levels of absolute rate of reinforcement. Two red stimuli, differing in duration, were arranged probabilistically on the center key of a three-key chamber. On completion of the center-key duration, the center keylight was extinguished and the two side keys were illuminated white. Correct responses were left-key pecks following the shorter duration and right-key pecks follo...

  11. Dynamic detection of a single bacterium: nonlinear rotation rate shifts of driven magnetic microsphere stages

    OpenAIRE

    McNaughton, Brandon H.; Agayan, Rodney R.; Kopelman, Raoul

    2006-01-01

    We report on a new technique which was used to detect single Escherichia coli that is based on the changes in the nonlinear rotation of a magnetic microsphere driven by an external magnetic field. The presence of one Escherichia Coli bacterium on the surface of a 2.0 micron magnetic microsphere caused an easily measurable change in the drag of the system and, therefore, in the nonlinear rotation rate. The straight-forward measurement uses standard microscopy techniques and the observed averag...

  12. Use of Schiller's test versus Pap smear to increase detection rate of cervical dysplasias

    OpenAIRE

    Ramaraju H. E.; Nagaveni Y. C.; A. A. Khazi

    2016-01-01

    Background: Application of Lugols iodine to cervix (Schillers test) is named as Visual Inspection of cervix after applying Lugols Iodine (VILI). VILI improves the detection rate of suspicious area over the cervix. The objectives of the study was to screening for early carcinoma or Dysplasia cervix by Schiller's test and Pap smear and to compare the results of Schiller's test with Pap smear results. Methods: The present prospective randomized control trials study was undertaken among 500 ...

  13. Factors influencing the detection rate of drug-related problems in community pharmacy

    DEFF Research Database (Denmark)

    Westerlund, T; Almarsdóttir, Anna Birna; Melander, A

    1999-01-01

    This study analyzes relationships between the number of drug-related problems detected in community pharmacy practice and the educational level and other characteristics of pharmacy personnel and their work sites. Random samples of pharmacists, prescriptionists and pharmacy technicians were drawn....... Previous participation in a study or activity on drug-related problems and the size of the pharmacy also had statistically significant effects on the problem detection rate. The use of open-ended questions to create a dialogue with the patient seemed to be a successful means to discover problems....... The results of this study indicate the importance of education and training of pharmacy personnel in detection of drug-related problems. This findings speaks in favor of increasing the pharmacist to other personnel ratio, provided the higher costs will be offset by societal benefits....

  14. SETI: The transmission rate of radio communication and the signal's detection

    CERN Document Server

    Fridman, P A

    2011-01-01

    The transmission rate of communication between radio telescopes on Earth and extraterrestrial intelligence (ETI) has been calculated up to the distances 1000 light years. Phase-shift-keying (PSK) and frequency-shift keying (FSK) modulation schemes are both considered here. It has been demonstrated that M-ary FSK is advantageous in terms of energy. Narrow-band pulses scattered over the spectrum can be the probable signals of ETI and modern SETI spectrum analyzers are well suited to searching for these types of signals. Such signals can be detected using the Hough transform which is a dedicated tool for detecting patterns on an image. The time-frequency plane representing the power output of the spectrum analyzer during the search for ETI gives an image from which the Hough transform (HT) can detect signal patterns with frequency drift.

  15. Computerized fetal heart rate analysis in labor: detection of intervals with un-assignable baseline

    International Nuclear Information System (INIS)

    The fetal heart rate (FHR) is monitored during labor to assess fetal health. Both visual and computerized interpretations of the FHR depend on assigning a baseline to detect key features such as accelerations or decelerations. However, it is sometimes impossible to assign a baseline reliably, by eye or by numerical methods. To address this issue, we used the Oxford Intrapartum FHR Database to derive an algorithm based on the distribution of the FHR that detects heart rate intervals without a clear baseline. We aimed to recognize when a fetus cannot maintain its heart rate baseline and use this to assist computerized FHR analysis. Twenty-three FHR windows (15 min long) were used to develop the method. The algorithm was then validated by comparison with experts who classified 50 FHR windows into two groups: baseline assignable or un-assignable. The average agreement between experts (κ = 0.76) was comparable to the agreement between method and experts (κ = 0.67). The algorithm was used in 22 559 patients with intrapartum FHR records to retrospectively determine the incidence of intervals (defined as 15 min windows) that had un-assignable baselines. Sixty-six percent had one or more such episodes at some stage, most commonly after the onset of pushing (55%) and least commonly pre-labor (16%). These episodes are therefore relatively common. Their detection should improve the reliability of computerized analysis and allow further studies of what they signify clinically

  16. Physical Activity in Individuals with Severe Mental Illness: Client versus Case Manager Ratings

    Science.gov (United States)

    Bezyak, Jill L.; Chan, Fong; Lee, Eun-Jeong; Catalano, Denise; Chiu, Chung-Yi

    2012-01-01

    The "Physical Activity Scale for Individuals With Physical Disabilities" was examined as a physical activity measure for people with severe mental illness. Case manager ratings were more closely related to body mass index than clients' ratings, challenging the accuracy of self-report physical activity measures for individuals with severe mental…

  17. A new islanding detection technique for multiple mini hydro based on rate of change of reactive power and load connecting strategy

    International Nuclear Information System (INIS)

    Highlights: • The requirement of DG interconnection with existing power system is discussed. • Various islanding detection techniques are discussed with their merits and demerits. • New islanding detection strategy is proposed for multiple mini hydro type DGs. • The proposed strategy is based on dq/dt and load connecting strategy. • The effectiveness of strategy is verified on various other cases. - Abstract: The interconnection of distributed generation (DG) into distribution networks is undergoing a rapid global expansion. It enhances the system’s reliability, while simultaneously reduces pollution problems related to the generation of electrical power. To fully utilize the benefits of DGs, certain technical issues need to be addressed. One of the most important issues in this context is islanding detection. This paper presents a new islanding detection technique that is suitable for multiple mini-hydro type DG units. The proposed strategy is based on the rate of change of reactive power and load connecting strategy to detect islanding within the system. For a large power mismatch, islanding is detected by rate of change of reactive power only. However, for a close power mismatch, the rate of change of reactive power initiates a load connecting strategy, which in turn alters the load on the distribution network. This load variation in the distribution network causes a variation in the rate of change of reactive power, which is utilized to distinguish islanding and other events. The simulation results show that the proposed strategy is effective in detecting islanding occurrence in a distribution network

  18. Variability in case-mix adjusted in-hospital cardiac arrest rates

    Science.gov (United States)

    Merchant, Raina M.; Yang, Lin; Becker, Lance B.; Berg, Robert A.; Nadkarni, Vinay; Nichol, Graham; Carr, Brendan G.; Mitra, Nandita; Bradley, Steven M.; Abella, Benjamin S.; Groeneveld, Peter W.

    2011-01-01

    Background It is unknown how in-hospital cardiac arrest (IHCA) rates vary across hospitals and predictors of variability. Objectives Measure variability in IHCA across hospitals and determine if hospital-level factors predict differences in case-mix adjusted event rates. Research design Get with the Guidelines Resuscitation (GWTG-R) (n=433 hospitals) was used to identify IHCA events between 2003-2007. The American Hospital Association survey, Medicare, and US Census were used to obtain detailed information about GWTG-R hospitals. Subjects adult patients with IHCA Measures Case-mix adjusted predicted IHCA rates were calculated for each hospital and variability across hospitals was compared. A regression model was used to predict case-mix adjusted event rates using hospital measures of volume, nurse-to-bed ratio, percent ICU beds, palliative care services, urban designation, volume of black patients, income, trauma designation, academic designation, cardiac surgery capability and a patient risk score. Results We evaluated 103,117 adult IHCAs at 433 US hospitals. The case mix adjusted IHCA event rate was highly variable across hospitals, median 1/1000 bed days (interquartile range: 0.7-1.3 events/1000 bed-days). In a multivariable regression model, case-mix adjusted IHCA event rates were highest in urban hospitals (rate ratio [RR] 1.1, 95% confidence interval [CI] 1.0-1.3, p=0.03) and hospitals with higher proportions of black patients (RR 1.2, 95% CI 1.0-1.3, p=0.01) and lower in larger hospitals (RR 0.54, 95% CI 0.45-0.66, p<.0001). Conclusion Case-mix adjusted IHCA event rates varied considerably across hospitals. Several hospital factors associated with higher IHCA event rates were consistent with factors often linked with lower hospital quality of care. PMID:22249921

  19. Rate of recurrence and malignant transformation in 88 cases with inverted papilloma between 1998-2008

    DEFF Research Database (Denmark)

    Nygren, Alexander; Kiss, Katalin; von Buchwald, Christian;

    2016-01-01

    continued need for long-term follow-up. The rate of malignant transformation in inverted papilloma cases has not changed in Denmark. Objectives Inverted papillomas are benign tumours located in the nasal cavity and paranasal sinuses. They are known for their tendency to recur after surgery and show invasive...... establish whether the recurrence rate and the rate of malignant transformation of IP have changed with the application of these new techniques. Method A retrospective study between 1998-2008 including 88 cases with inverted papilloma. Results In total, 25.3% had recurrence. Combined surgical approach with...

  20. Global parameter optimization for maximizing radioisotope detection probabilities at fixed false alarm rates

    International Nuclear Information System (INIS)

    Today there is a tremendous amount of interest in systems that can detect radiological or nuclear threats. Many of these systems operate in extremely high throughput situations where delays caused by false alarms can have a significant negative impact. Thus, calculating the tradeoff between detection rates and false alarm rates is critical for their successful operation. Receiver operating characteristic (ROC) curves have long been used to depict this tradeoff. The methodology was first developed in the field of signal detection. In recent years it has been used increasingly in machine learning and data mining applications. It follows that this methodology could be applied to radiological/nuclear threat detection systems. However many of these systems do not fit into the classic principles of statistical detection theory because they tend to lack tractable likelihood functions and have many parameters, which, in general, do not have a one-to-one correspondence with the detection classes. This work proposes a strategy to overcome these problems by empirically finding parameter values that maximize the probability of detection for a selected number of probabilities of false alarm. To find these parameter values a statistical global optimization technique that seeks to estimate portions of a ROC curve is proposed. The optimization combines elements of simulated annealing with elements of genetic algorithms. Genetic algorithms were chosen because they can reduce the risk of getting stuck in local minima. However classic genetic algorithms operate on arrays of Booleans values or bit strings, so simulated annealing is employed to perform mutation in the genetic algorithm. The presented initial results were generated using an isotope identification algorithm developed at Johns Hopkins University Applied Physics Laboratory. The algorithm has 12 parameters: 4 real-valued and 8 Boolean. A simulated dataset was used for the optimization study; the 'threat' set of spectra

  1. Global parameter optimization for maximizing radioisotope detection probabilities at fixed false alarm rates

    Energy Technology Data Exchange (ETDEWEB)

    Portnoy, David, E-mail: david.portnoy@jhuapl.edu [Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723 (United States); Feuerbach, Robert; Heimberg, Jennifer [Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723 (United States)

    2011-10-01

    Today there is a tremendous amount of interest in systems that can detect radiological or nuclear threats. Many of these systems operate in extremely high throughput situations where delays caused by false alarms can have a significant negative impact. Thus, calculating the tradeoff between detection rates and false alarm rates is critical for their successful operation. Receiver operating characteristic (ROC) curves have long been used to depict this tradeoff. The methodology was first developed in the field of signal detection. In recent years it has been used increasingly in machine learning and data mining applications. It follows that this methodology could be applied to radiological/nuclear threat detection systems. However many of these systems do not fit into the classic principles of statistical detection theory because they tend to lack tractable likelihood functions and have many parameters, which, in general, do not have a one-to-one correspondence with the detection classes. This work proposes a strategy to overcome these problems by empirically finding parameter values that maximize the probability of detection for a selected number of probabilities of false alarm. To find these parameter values a statistical global optimization technique that seeks to estimate portions of a ROC curve is proposed. The optimization combines elements of simulated annealing with elements of genetic algorithms. Genetic algorithms were chosen because they can reduce the risk of getting stuck in local minima. However classic genetic algorithms operate on arrays of Booleans values or bit strings, so simulated annealing is employed to perform mutation in the genetic algorithm. The presented initial results were generated using an isotope identification algorithm developed at Johns Hopkins University Applied Physics Laboratory. The algorithm has 12 parameters: 4 real-valued and 8 Boolean. A simulated dataset was used for the optimization study; the 'threat' set of

  2. Detection of change points in underlying earthquake rates, with application to global mega-earthquakes

    Science.gov (United States)

    Touati, Sarah; Naylor, Mark; Main, Ian

    2016-02-01

    The recent spate of mega-earthquakes since 2004 has led to speculation of an underlying change in the global `background' rate of large events. At a regional scale, detecting changes in background rate is also an important practical problem for operational forecasting and risk calculation, for example due to volcanic processes, seismicity induced by fluid injection or withdrawal, or due to redistribution of Coulomb stress after natural large events. Here we examine the general problem of detecting changes in background rate in earthquake catalogues with and without correlated events, for the first time using the Bayes factor as a discriminant for models of varying complexity. First we use synthetic Poisson (purely random) and Epidemic-Type Aftershock Sequence (ETAS) models (which also allow for earthquake triggering) to test the effectiveness of many standard methods of addressing this question. These fall into two classes: those that evaluate the relative likelihood of different models, for example using Information Criteria or the Bayes Factor; and those that evaluate the probability of the observations (including extreme events or clusters of events) under a single null hypothesis, for example by applying the Kolmogorov-Smirnov and `runs' tests, and a variety of Z-score tests. The results demonstrate that the effectiveness among these tests varies widely. Information Criteria worked at least as well as the more computationally expensive Bayes factor method, and the Kolmogorov-Smirnov and runs tests proved to be the relatively ineffective in reliably detecting a change point. We then apply the methods tested to events at different thresholds above magnitude M ≥ 7 in the global earthquake catalogue since 1918, after first declustering the catalogue. This is most effectively done by removing likely correlated events using a much lower magnitude threshold (M ≥ 5), where triggering is much more obvious. We find no strong evidence that the background rate of large

  3. Fetal QRS detection and heart rate estimation: a wavelet-based approach.

    Science.gov (United States)

    Almeida, Rute; Gonçalves, Hernâni; Bernardes, João; Rocha, Ana Paula

    2014-08-01

    Fetal heart rate monitoring is used for pregnancy surveillance in obstetric units all over the world but in spite of recent advances in analysis methods, there are still inherent technical limitations that bound its contribution to the improvement of perinatal indicators. In this work, a previously published wavelet transform based QRS detector, validated over standard electrocardiogram (ECG) databases, is adapted to fetal QRS detection over abdominal fetal ECG. Maternal ECG waves were first located using the original detector and afterwards a version with parameters adapted for fetal physiology was applied to detect fetal QRS, excluding signal singularities associated with maternal heartbeats. Single lead (SL) based marks were combined in a single annotator with post processing rules (SLR) from which fetal RR and fetal heart rate (FHR) measures can be computed. Data from PhysioNet with reference fetal QRS locations was considered for validation, with SLR outperforming SL including ICA based detections. The error in estimated FHR using SLR was lower than 20 bpm for more than 80% of the processed files. The median error in 1 min based FHR estimation was 0.13 bpm, with a correlation between reference and estimated FHR of 0.48, which increased to 0.73 when considering only records for which estimated FHR > 110 bpm. This allows us to conclude that the proposed methodology is able to provide a clinically useful estimation of the FHR. PMID:25070210

  4. Fetal QRS detection and heart rate estimation: a wavelet-based approach

    International Nuclear Information System (INIS)

    Fetal heart rate monitoring is used for pregnancy surveillance in obstetric units all over the world but in spite of recent advances in analysis methods, there are still inherent technical limitations that bound its contribution to the improvement of perinatal indicators. In this work, a previously published wavelet transform based QRS detector, validated over standard electrocardiogram (ECG) databases, is adapted to fetal QRS detection over abdominal fetal ECG. Maternal ECG waves were first located using the original detector and afterwards a version with parameters adapted for fetal physiology was applied to detect fetal QRS, excluding signal singularities associated with maternal heartbeats. Single lead (SL) based marks were combined in a single annotator with post processing rules (SLR) from which fetal RR and fetal heart rate (FHR) measures can be computed. Data from PhysioNet with reference fetal QRS locations was considered for validation, with SLR outperforming SL including ICA based detections. The error in estimated FHR using SLR was lower than 20 bpm for more than 80% of the processed files. The median error in 1 min based FHR estimation was 0.13 bpm, with a correlation between reference and estimated FHR of 0.48, which increased to 0.73 when considering only records for which estimated FHR > 110 bpm. This allows us to conclude that the proposed methodology is able to provide a clinically useful estimation of the FHR. (paper)

  5. Real-time remote detection and measurement for airborne imaging spectroscopy: a case study with methane

    Science.gov (United States)

    Thompson, D. R.; Leifer, I.; Bovensmann, H.; Eastwood, M.; Fladeland, M.; Frankenberg, C.; Gerilowski, K.; Green, R. O.; Kratwurst, S.; Krings, T.; Luna, B.; Thorpe, A. K.

    2015-10-01

    Localized anthropogenic sources of atmospheric CH4 are highly uncertain and temporally variable. Airborne remote measurement is an effective method to detect and quantify these emissions. In a campaign context, the science yield can be dramatically increased by real-time retrievals that allow operators to coordinate multiple measurements of the most active areas. This can improve science outcomes for both single- and multiple-platform missions. We describe a case study of the NASA/ESA CO2 and MEthane eXperiment (COMEX) campaign in California during June and August/September 2014. COMEX was a multi-platform campaign to measure CH4 plumes released from anthropogenic sources including oil and gas infrastructure. We discuss principles for real-time spectral signature detection and measurement, and report performance on the NASA Next Generation Airborne Visible Infrared Spectrometer (AVIRIS-NG). AVIRIS-NG successfully detected CH4 plumes in real-time at Gb s-1 data rates, characterizing fugitive releases in concert with other in situ and remote instruments. The teams used these real-time CH4 detections to coordinate measurements across multiple platforms, including airborne in situ, airborne non-imaging remote sensing, and ground-based in situ instruments. To our knowledge this is the first reported use of real-time trace-gas signature detection in an airborne science campaign, and presages many future applications. Post-analysis demonstrates matched filter methods providing noise-equivalent (1σ) detection sensitivity for 1.0 % CH4 column enhancements equal to 141 ppm m.

  6. Heart rate and blood pressure control in obesity - how to detect early dysregulation?

    Science.gov (United States)

    Javorka, Michal; Turianikova, Zuzana; Tonhajzerova, Ingrid; Lazarova, Zuzana; Czippelova, Barbora; Javorka, Kamil

    2016-09-01

    Obesity is accompanied by many severe complications including various cardiovascular disorders. An impairment of cardiovascular control by autonomic nervous system could be one of the possible links between obesity and cardiovascular complications development. The aim of this study was to compare spontaneous heart rate and systolic blood pressure oscillations reflecting cardiovascular autonomic control of young obese subjects with normal control subjects by linear and nonlinear methods and to find sensitive markers of early autonomic dysregulation. Continuous recordings of beat-to-beat systolic blood pressure and RR intervals from ECG were obtained from 40 obese subjects (25 female, age 14·2 [13·1-16·1] (median [interquartile range]) years) and gender and age matched non-obese control subjects. In addition to linear measures (time and frequency domain), we performed recurrence quantification analysis (RQA) and multiscale entropy analysis for both signals. While no significant differences in heart rate and systolic blood pressure dynamics were detected by linear measures and MSE, analysis of recurrence plots from RR intervals time series showed significant differences - indices trapping time and maximal length of vertical from RQA were significantly higher in obese compared to control group. We conclude that heart rate and blood pressure control by autonomic nervous system in young obese subjects is relatively well preserved. However, novel RQA-related measures are able to detect early subtle abnormalities in cardiac autonomic control in obese subjects indicating decreased signal complexity. PMID:25684329

  7. Micrometeorites in Antarctic ice detected by Ir. Estimation of 120k year old accretion rate

    International Nuclear Information System (INIS)

    The accretion rate of micrometeorites (MMs) was estimated from Ir contents in snow around Dome Fuji Station and ice shards obtained during ice core drilling at Dome Fuji Station, Antarctica. The snow and ice shards were melted and filtered from the residues. Although MMs were not found on filters, we tried to detect them from the residues as Ir peaks determined by instrumental neutron activation analysis (INAA). Although Ir is very rare in the earth's crust, its concentration is high in extraterrestrial matter (e.g., chondrites). Trace amounts of Ir can be easily detected by INAA, because the cross section of Ir is relatively large (e.g., 309 barn). The accretion rates were estimated for 120k year ago, 5k year ago and at present, as (3.2 ± 0.9) x 102 t/year (8.6 ± 0.18) x 103 t/year and (1.3 ± 0.10) x 103 t/year, respectively. These estimates were comparable to those of previous studies, however the rate of 120k year ago was approximately an order of magnitudes lower than the others. (author)

  8. Detecting Parental Deception Using a Behavior Rating Scale during Assessment of Attention-Deficit/Hyperactivity Disorder: An Experimental Study

    Science.gov (United States)

    Norfolk, Philip A.; Floyd, Randy G.

    2016-01-01

    It is often assumed that parents completing behavior rating scales during the assessment of attention-deficit/hyperactivity disorder (ADHD) can deliberately manipulate the outcomes of the assessment. To detect these actions, items designed to detect over-reporting or under-reporting of results are sometimes embedded in such rating scales. This…

  9. Do Case Rates Affect Physicians' Clinical Practice in Radiation Oncology?: An Observational Study

    Science.gov (United States)

    Loy, Bryan A.; Shkedy, Clive I.; Powell, Adam C.; Happe, Laura E.; Royalty, Julie A.; Miao, Michael T.; Smith, Gary L.; Long, James W.; Gupta, Amit K.

    2016-01-01

    Case rate payments combined with utilization monitoring may have the potential to improve the quality of care by reducing over and under-treatment. Thus, a national managed care organization introduced case rate payments at one multi-site radiation oncology provider while maintaining only fee-for-service payments at others. This study examined whether the introduction of the payment method had an effect on radiation fractions administered when compared to clinical guidelines. The number of fractions of radiation therapy delivered to patients with bone metastases, breast, lung, prostate, and skin cancer was assessed for concordance with clinical guidelines. The proportion of guideline-based care ascertained from the payer's claims database was compared before (2011) and after (2013) the payment method introduction using relative risks (RR). After the introduction of case rates, there were no significant changes in guideline-based care in breast, lung, and skin cancer; however, patients with bone metastases and prostate cancer were significantly more likely to have received guideline-based care (RR = 2.0 and 1.1, respectively, p<0.05). For the aggregate of all cancers, the under-treatment rate significantly declined (p = 0.008) from 4% to 0% after the introduction of case rate payments, while the over-treatment rate remained steady at 9%, with no significant change (p = 0.20). These findings suggest that the introduction of case rate payments did not adversely affect the rate of guideline-based care at the provider examined. Additional research is needed to isolate the effect of the payment model and assess implications in other populations. PMID:26870963

  10. Do Case Rates Affect Physicians' Clinical Practice in Radiation Oncology?: An Observational Study.

    Directory of Open Access Journals (Sweden)

    Bryan A Loy

    Full Text Available Case rate payments combined with utilization monitoring may have the potential to improve the quality of care by reducing over and under-treatment. Thus, a national managed care organization introduced case rate payments at one multi-site radiation oncology provider while maintaining only fee-for-service payments at others. This study examined whether the introduction of the payment method had an effect on radiation fractions administered when compared to clinical guidelines. The number of fractions of radiation therapy delivered to patients with bone metastases, breast, lung, prostate, and skin cancer was assessed for concordance with clinical guidelines. The proportion of guideline-based care ascertained from the payer's claims database was compared before (2011 and after (2013 the payment method introduction using relative risks (RR. After the introduction of case rates, there were no significant changes in guideline-based care in breast, lung, and skin cancer; however, patients with bone metastases and prostate cancer were significantly more likely to have received guideline-based care (RR = 2.0 and 1.1, respectively, p<0.05. For the aggregate of all cancers, the under-treatment rate significantly declined (p = 0.008 from 4% to 0% after the introduction of case rate payments, while the over-treatment rate remained steady at 9%, with no significant change (p = 0.20. These findings suggest that the introduction of case rate payments did not adversely affect the rate of guideline-based care at the provider examined. Additional research is needed to isolate the effect of the payment model and assess implications in other populations.

  11. [Design of Oxygen Saturation, Heart Rate, Respiration Rate Detection System Based on Smartphone of Android Operating System].

    Science.gov (United States)

    Zhu, Mingshan; Zeng, Bixin

    2015-03-01

    In this paper, we designed an oxygen saturation, heart rate, respiration rate monitoring system based on smartphone of android operating system, physiological signal acquired by MSP430 microcontroller and transmitted by Bluetooth module. PMID:26524782

  12. IMPROVED THEORETICAL PREDICTIONS OF MICROLENSING RATES FOR THE DETECTION OF PRIMORDIAL BLACK HOLE DARK MATTER

    Energy Technology Data Exchange (ETDEWEB)

    Cieplak, Agnieszka M.; Griest, Kim [Department of Physics, University of California, San Diego, CA 92093 (United States)

    2013-04-20

    Primordial black holes (PBHs) remain a dark matter (DM) candidate of the Standard Model of Particle Physics. Previously, we proposed a new method of constraining the remaining PBH DM mass range using microlensing of stars monitored by NASA's Kepler mission. We improve this analysis using a more accurate treatment of the population of the Kepler source stars, their variability, and limb darkening. We extend the theoretically detectable PBH DM mass range down to 2 Multiplication-Sign 10{sup -10} M{sub Sun }, two orders of magnitude below current limits and one-third order of magnitude below our previous estimate. We address how to extract the DM properties, such as mass and spatial distribution, if PBH microlensing events were detected. We correct an error in a well-known finite-source limb-darkening microlensing formula and also examine the effects of varying the light curve cadence on PBH DM detectability. We also introduce an approximation for estimating the predicted rate of detection per star as a function of the star's properties, thus allowing for selection of source stars in future missions, and extend our analysis to planned surveys, such as the Wide-Field Infrared Survey Telescope.

  13. IMPROVED THEORETICAL PREDICTIONS OF MICROLENSING RATES FOR THE DETECTION OF PRIMORDIAL BLACK HOLE DARK MATTER

    International Nuclear Information System (INIS)

    Primordial black holes (PBHs) remain a dark matter (DM) candidate of the Standard Model of Particle Physics. Previously, we proposed a new method of constraining the remaining PBH DM mass range using microlensing of stars monitored by NASA's Kepler mission. We improve this analysis using a more accurate treatment of the population of the Kepler source stars, their variability, and limb darkening. We extend the theoretically detectable PBH DM mass range down to 2 × 10–10 M☉, two orders of magnitude below current limits and one-third order of magnitude below our previous estimate. We address how to extract the DM properties, such as mass and spatial distribution, if PBH microlensing events were detected. We correct an error in a well-known finite-source limb-darkening microlensing formula and also examine the effects of varying the light curve cadence on PBH DM detectability. We also introduce an approximation for estimating the predicted rate of detection per star as a function of the star's properties, thus allowing for selection of source stars in future missions, and extend our analysis to planned surveys, such as the Wide-Field Infrared Survey Telescope.

  14. Improved Theoretical Predictions of Microlensing Rates for the Detection of Primordial Black Hole Dark Matter

    Science.gov (United States)

    Cieplak, Agnieszka M.; Griest, Kim

    2013-04-01

    Primordial black holes (PBHs) remain a dark matter (DM) candidate of the Standard Model of Particle Physics. Previously, we proposed a new method of constraining the remaining PBH DM mass range using microlensing of stars monitored by NASA's Kepler mission. We improve this analysis using a more accurate treatment of the population of the Kepler source stars, their variability, and limb darkening. We extend the theoretically detectable PBH DM mass range down to 2 × 10-10 M ⊙, two orders of magnitude below current limits and one-third order of magnitude below our previous estimate. We address how to extract the DM properties, such as mass and spatial distribution, if PBH microlensing events were detected. We correct an error in a well-known finite-source limb-darkening microlensing formula and also examine the effects of varying the light curve cadence on PBH DM detectability. We also introduce an approximation for estimating the predicted rate of detection per star as a function of the star's properties, thus allowing for selection of source stars in future missions, and extend our analysis to planned surveys, such as the Wide-Field Infrared Survey Telescope.

  15. Improved Theoretical Predictions of Microlensing Rates for the Detection of Primordial Black Hole Dark Matter

    CERN Document Server

    Cieplak, Agnieszka M

    2012-01-01

    Primordial Black Holes (PBHs) remain a Dark Matter (DM) candidate of the Standard Model of Particle Physics. Previously, we proposed a new method of constraining the remaining PBH DM mass range using microlensing of stars monitored by NASA's Kepler mission. We improve this analysis using a more accurate treatment of the population of the Kepler source stars, their variability and limb-darkening. We extend the theoretically detectable PBH DM mass range down to $2\\times10^{-10} M_\\sun$, two orders of magnitude below current limits and one third order of magnitude below our previous estimate. We address how to extract the DM properties such as mass and spatial distribution if PBH microlensing events were detected. We correct an error in a well-known finite-source limb-darkening microlensing formula and also examine the effects of varying the light curve cadence on PBH DM detectability. We also introduce an approximation for estimating the predicted rate of detection per star as a function of the star's propertie...

  16. How Knowledge Organizations Work: The Case of Detectives

    Science.gov (United States)

    Gottschalk, Petter; Holgersson, Stefan; Karlsen, Jan Terje

    2009-01-01

    Purpose: The purpose of this paper is to conceptualize detectives in police investigations as knowledge workers. Design/methodology/approach: The paper is based on a literature review covering knowledge organizations, police organizations, police investigations, and detectives as knowledge workers. Findings: The paper finds that the changing role…

  17. Digital Mammography Screening: Does Age Influence the Detection Rates of Low-, Intermediate-, and High-Grade Ductal Carcinoma in Situ?

    Science.gov (United States)

    Weigel, Stefanie; Hense, Hans W; Heidrich, Jan; Berkemeyer, Shoma; Heindel, Walter; Heidinger, Oliver

    2016-03-01

    Purpose To investigate the association between age at screening and detection rates for ductal carcinoma in situ (DCIS) separately for different nuclear grades after introduction of a population-based digital mammography screening program. Materials and Methods The retrospective study was approved by the ethics board and did not require informed consent. In 733 905 women aged 50-69 years who participated in a screening program for the first time in 2005-2008 (baseline examinations were performed with digital mammography), DCIS detection rates were determined for 5-year age groups (detection rates per 1000 women screened) to distinguish high-, intermediate-, and low-grade DCIS. Multivariable logistic regression was used to compare detection rates between age groups by adjusting for screening units (P DCIS diagnoses among 733 905 women (detection rate, 1.35‰): 419 diagnoses of high-grade DCIS (detection rate, 0.57‰), 388 diagnoses of intermediate-grade DCIS (detection rate, 0.53‰), and 182 diagnoses of low-grade DCIS (detection rate, 0.25‰). Detection rate for types of DCIS combined increased significantly across age groups (50-54 years, detection rate of 1.15‰ [254 of 220 985 women]; 55-59 years, detection rate of 1.23‰ [218 of 177 782 women]; 60-64 years, detection rate of 1.34‰ [201 of 150 415 women]; and 65-69 years, detection rate of 1.71‰ [316 of 184 723 women]; P DCIS showed a significant increase with age (odds ratio, 1.18 per 5-year age group; P DCIS (odds ratio, 1.11; P = .016) and not significant for low-grade DCIS (P = .10). Conclusion Total DCIS detection rates increase with age, mostly because of an increase in high- and intermediate-grade DCIS, which are precursor lesions that carry a higher risk for transition to more aggressive invasive breast cancer than low-grade DCIS. (©) RSNA, 2015. PMID:26505802

  18. Comparison of detectable bleeding rates of radiopharmaceuticals for localization of gastrointestinal bleeding in sheep using a closed system

    Energy Technology Data Exchange (ETDEWEB)

    Owunwanne, A.; Sadek, S.; Yacoub, T.; Awdeh, M.; Abdel-Dayem, H.M. (Kuwait Univ. (Kuwait). Dept. of Nuclear Medicine); Al-Wafai, I.; Vallgren, S. (Kuwait Univ. (Kuwait). Dept. of Surgery)

    1989-06-01

    The closed experimental animal model system was used to compare the detectable gastrointestinal (GI) bleeding rates of {sup 99m}Tc-DTPA, {sup 99m}Tc-RBCs and {sup 99m}Tc tin colloid in sheep. The three radiopharmaceuticals were used to detect the upper GI bleeding sites at rates of 0.57 and 0.25 ml/min. At the lower bleeding rate of 0.1 ml/min, both {sup 99m}Tc-DTPA and {sup 99m}Tc-RBCs were successful in detecting the bleeding site. At the lowest rate of 0.07 ml/min only {sup 99m}Tc-DTPA was successful in detecting the bleeding site. The results indicate that {sup 99m}Tc-DTPA is the most useful {sup 99m}Tc radiopharmaceutical for detecting the upper GI bleeding site at the slowest bleeding rate studied. (orig.).

  19. Automatic optimisation of gamma dose rate sensor networks: The DETECT Optimisation Tool

    Science.gov (United States)

    Helle, K. B.; Müller, T. O.; Astrup, P.; Dyve, J. E.

    2014-05-01

    Fast delivery of comprehensive information on the radiological situation is essential for decision-making in nuclear emergencies. Most national radiological agencies in Europe employ gamma dose rate sensor networks to monitor radioactive pollution of the atmosphere. Sensor locations were often chosen using regular grids or according to administrative constraints. Nowadays, however, the choice can be based on more realistic risk assessment, as it is possible to simulate potential radioactive plumes. To support sensor planning, we developed the DETECT Optimisation Tool (DOT) within the scope of the EU FP 7 project DETECT. It evaluates the gamma dose rates that a proposed set of sensors might measure in an emergency and uses this information to optimise the sensor locations. The gamma dose rates are taken from a comprehensive library of simulations of atmospheric radioactive plumes from 64 source locations. These simulations cover the whole European Union, so the DOT allows evaluation and optimisation of sensor networks for all EU countries, as well as evaluation of fencing sensors around possible sources. Users can choose from seven cost functions to evaluate the capability of a given monitoring network for early detection of radioactive plumes or for the creation of dose maps. The DOT is implemented as a stand-alone easy-to-use JAVA-based application with a graphical user interface and an R backend. Users can run evaluations and optimisations, and display, store and download the results. The DOT runs on a server and can be accessed via common web browsers; it can also be installed locally.

  20. The Enhanced Coronal Mass Ejection Detection Rate since the Solar Cycle 23 Polar Field Reversal

    Science.gov (United States)

    Petrie, Gordon

    2016-05-01

    Compared to cycle 23, coronal mass ejections (CMEs) with angular widths >30° have been observed to occur at a higher rate during solar cycle 24, per sunspot number. This result is supported by data from three independent databases constructed using Large Angle and Spectrometric Coronagraph Experiment coronagraph images, two employing automated detection techniques and one compiled manually by human observers. According to the two databases that cover a larger field of view, the enhanced CME rate actually began shortly after the cycle 23 polar field reversal, in 2004, when the polar fields returned with a 40% reduction in strength and the interplanetary radial magnetic field became ≈30% weaker. This result is consistent with the link between anomalous CME expansion and the heliospheric total pressure decrease recently reported by Gopalswamy et al.

  1. DETECTING CONGESTIVE HEART FAILURE USING HEART RATE SEQUENTIAL TREND ANALYSIS PLOT

    Directory of Open Access Journals (Sweden)

    SRINIVAS KUNTAMALLA,

    2010-12-01

    Full Text Available Heart rate variability analysis is gaining acceptance as a potential non-invasive means of autonomic nervous system assessment in research as well as clinical domains. In this study, a nonlinear analysis method is developed to detect congestive heart failure. The data obtained from an online and widely used public database (i.e., MIT/BIH physionet database, is used for testing the performance of the method. The method developed is based on the sequential trend analysis plot of heart rate variability and correlates well with the characteristic autonomic nervous system regulations in congestive heart failure. The proposed method can be used for screening as well as diagnosing the heart failure patients. The algorithm is computationally simple and can be implemented in a real time processing hardware. This method classifies 31 out of 32 subjects and has the highest discrimination power in terms of sensitivity, specificity and accuracy.

  2. Cooperation schemes for rate enhancement in detect-and-forward relay channels

    KAUST Repository

    Benjillali, Mustapha

    2010-05-01

    To improve the spectral efficiency of "Detect-and-Forward" (DetF) half-duplex relaying in fading channels, we propose a cooperation scheme where the relay uses a modulation whose order is higher than the one at the source. In a new common framework, we show that the proposed scheme offers considerable gains - in terms of achievable information rates - compared to the conventional DetF relaying schemes for both orthogonal and non-orthogonal source/relay cooperation. This allows us to propose an adaptive cooperation scheme based on the maximization of the information rate at the destination which needs to observe only the average signal-to-noise ratios of direct and relaying links. ©2010 IEEE.

  3. On the Enhanced Coronal Mass Ejection Detection Rate since the Solar Cycle 23 Polar Field Reversal

    Science.gov (United States)

    Petrie, G. J. D.

    2015-10-01

    Compared to cycle 23, coronal mass ejections (CMEs) with angular widths >30° have been observed to occur at a higher rate during solar cycle 24, per sunspot number. This result is supported by data from three independent databases constructed using Large Angle and Spectrometric Coronagraph Experiment coronagraph images, two employing automated detection techniques and one compiled manually by human observers. According to the two databases that cover a larger field of view, the enhanced CME rate actually began shortly after the cycle 23 polar field reversal, in 2004, when the polar fields returned with a 40% reduction in strength and the interplanetary radial magnetic field became ≈30% weaker. This result is consistent with the link between anomalous CME expansion and the heliospheric total pressure decrease recently reported by Gopalswamy et al.

  4. On the enhanced coronal mass ejection detection rate since the solar cycle 23 polar field reversal

    CERN Document Server

    Petrie, Gordon

    2015-01-01

    Coronal mass ejections (CMEs) with angular width $> 30^{\\circ}$ have been observed to occur at a higher rate during solar cycle 24 compared to cycle 23, per sunspot number. This result is supported by data from three independent databases constructed using Large Angle and Spectrometric Coronagraph Experiment (LASCO) coronagraph images, two employing automated detection techniques and one compiled manually by human observers. According to the two databases that cover a larger field of view, the enhanced CME rate actually began shortly after the cycle 23 polar field reversal, in 2004, when the polar fields returned with a 40\\% reduction in strength and interplanetary radial magnetic field became $\\approx 30\\%$ weaker. This result is consistent with the link between anomalous CME expansion and heliospheric total pressure decrease recently reported by Gopalswamy et al.

  5. Calculating inspector probability of detection using performance demonstration program pass rates

    Science.gov (United States)

    Cumblidge, Stephen; D'Agostino, Amy

    2016-02-01

    The United States Nuclear Regulatory Commission (NRC) staff has been working since the 1970's to ensure that nondestructive testing performed on nuclear power plants in the United States will provide reasonable assurance of structural integrity of the nuclear power plant components. One tool used by the NRC has been the development and implementation of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code Section XI Appendix VIII[1] (Appendix VIII) blind testing requirements for ultrasonic procedures, equipment, and personnel. Some concerns have been raised, over the years, by the relatively low pass rates for the Appendix VIII qualification testing. The NRC staff has applied statistical tools and simulations to determine the expected probability of detection (POD) for ultrasonic examinations under ideal conditions based on the pass rates for the Appendix VIII qualification tests for the ultrasonic testing personnel. This work was primarily performed to answer three questions. First, given a test design and pass rate, what is the expected overall POD for inspectors? Second, can we calculate the probability of detection for flaws of different sizes using this information? Finally, if a previously qualified inspector fails a requalification test, does this call their earlier inspections into question? The calculations have shown that one can expect good performance from inspectors who have passed appendix VIII testing in a laboratory-like environment, and the requalification pass rates show that the inspectors have maintained their skills between tests. While these calculations showed that the PODs for the ultrasonic inspections are very good under laboratory conditions, the field inspections are conducted in a very different environment. The NRC staff has initiated a project to systematically analyze the human factors differences between qualification testing and field examinations. This work will be used to evaluate and prioritize

  6. Heart Rate Variability based Classification of Normal and Hypertension Cases by Linear-nonlinear Method

    OpenAIRE

    M. G. Poddar; Vinod Kumar; Yash Paul Sharma

    2014-01-01

    The aim of this study is to analyse and compare the heart rate variability (HRV) of normal and hypertension cases using time domain, frequency domain, and nonlinear methods. For short term HRV analysis, a five-minute electrocardiogram (ECG) of 57 normal and 56 hypertension subjects were recorded with prior verification of their clinical status by a cardiologist. Most time domain features of hypertension cases have clearly reduced values over normal subjects, frequency domain features, like po...

  7. Explicit Solution of Worst-Case Secrecy Rate for MISO Wiretap Channels With Spherical Uncertainty

    Science.gov (United States)

    Li, Jiangyuan; Petropulu, Athina P.

    2012-07-01

    A multiple-input single-output (MISO) wiretap channel model is considered, that includes a multi-antenna transmitter, a single-antenna legitimate receiver and a single-antenna eavesdropper. For the scenario in which spherical uncertainty for both the legitimate and the eavesdropper channels is included, the problem of finding the optimal input covariance that maximizes the worst-case secrecy rate subject to a power constraint, is considered, and an explicit expression for the maximum worst-case secrecy rate is provided.

  8. Explicit Solution of Worst-Case Secrecy Rate for MISO Wiretap Channels with Spherical Uncertainty

    CERN Document Server

    Li, Jiangyuan

    2011-01-01

    A multiple-input single-output (MISO) wiretap channel model is considered, that includes a multi-antenna transmitter, a single-antenna legitimate receiver and a single-antenna eavesdropper. For the scenario in which spherical uncertainty for both the legitimate and the eavesdropper channels is included, the problem of finding the optimal input covariance that maximizes the worst-case secrecy rate subject to a power constraint, is considered, and an explicit expression for the maximum worst-case secrecy rate is provided.

  9. On Trade Impact of Exchange Rate Volatility and Institutional Quality: The Case of Central European Countries.

    OpenAIRE

    Ferto, Imre; Fogarasi, Jozsef

    2011-01-01

    This paper explores the effect of exchange rate volatility and of the institutional quality on international trade flows of transition economies in Central European Countries by applying a gravity model of balance panel between 1999 and 2008. The results show that nominal exchange rate volatility has had a significant negative effect on trade by applying Psuedo- Maximum-Likelihood (PML) estimator method over this period. The institutional quality need to be improved in case of size of governm...

  10. Count rate determination for quality control of combined lung ventilation and perfusion scintigraphy. Case report

    International Nuclear Information System (INIS)

    We present the case of a 43-year-old male patient who suffered from a massive pulmonary embolism, induced by a peritoneovenous shunt of the Denver type. Calculation of the count rates of the ventilation and perfusion scintigraphy respectively showed a too low ventilation/perfusion ratio. After reinjection of additional 99mTc-MAA the second perfusion study showed further mismatch areals. Count rate ratio determination is essential as a clinical quality control. (orig.)

  11. RS slope detection algorithm for extraction of heart rate from noisy, multimodal recordings.

    Science.gov (United States)

    Gierałtowski, Jan; Ciuchciński, Kamil; Grzegorczyk, Iga; Kośna, Katarzyna; Soliński, Mateusz; Podziemski, Piotr

    2015-08-01

    Current gold-standard algorithms for heart beat detection do not work properly in the case of high noise levels and do not make use of multichannel data collected by modern patient monitors. The main idea behind the method presented in this paper is to detect the most prominent part of the QRS complex, i.e. the RS slope. We localize the RS slope based on the consistency of its characteristics, i.e. adequate, automatically determined amplitude and duration. It is a very simple and non-standard, yet very effective, solution. Minor data pre-processing and parameter adaptations make our algorithm fast and noise-resistant. As one of a few algorithms in the PhysioNet/Computing in Cardiology Challenge 2014, our algorithm uses more than two channels (i.e. ECG, BP, EEG, EOG and EMG). Simple fundamental working rules make the algorithm universal: it is able to work on all of these channels with no or only little changes. The final result of our algorithm in phase III of the Challenge was 86.38 (88.07 for a 200 record test set), which gave us fourth place. Our algorithm shows that current standards for heart beat detection could be improved significantly by taking a multichannel approach. This is an open-source algorithm available through the PhysioNet library. PMID:26218763

  12. Dark matter direct detection rate in a generic model with micrOMEGAs_2.2

    Science.gov (United States)

    Bélanger, G.; Boudjema, F.; Pukhov, A.; Semenov, A.

    2009-05-01

    We present a new module of the micrOMEGAs package for the calculation of WIMP-nuclei elastic scattering cross sections relevant for the direct detection of dark matter through its interaction with nuclei in a large detector. With this new module, the computation of the direct detection rate is performed automatically for a generic model of new physics which contains a WIMP candidate. This model needs to be implemented within micrOMEGAs 2.2. Program summaryProgram title: micrOMEGAs2.2 Catalogue identifier: ADQR_v2_2 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADQR_v2_2.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 206 949 No. of bytes in distributed program, including test data, etc.: 2 245 230 Distribution format: tar.gz Programming language: C and Fortran Computer: PC, Alpha, Mac Operating system: UNIX (Linux, OSF1, Darwin, Cygwin) RAM: 17 MB depending on the number of processes required Classification: 1.9, 11.6 Catalogue identifier of previous version: ADQR_v2_1 Journal reference of previous version: Comput. Phys. Comm. 177 (2007) 894 Does the new version supersede the previous version?: Yes Nature of problem: Calculation of the relic density and of direct and indirect detection rates of the lightest stable particle in a generic new model of particle physics. Solution method: In numerically solving the evolution equation for the density of darkmatter, relativistic formulae for the thermal average are used. All tree-level processes for annihilation and coannihilation of new particles in the model are included. The cross-sections for all processes are calculated exactly with CalcHEP after definition of a model file. Higher-order QCD corrections to Higgs couplings to quark pairs are included. The coefficients of the effective Lagrangian which describes the

  13. Expansion of brucellosis detection in the country of Georgia by screening household members of cases and neighboring community members

    OpenAIRE

    Sanodze, Lia; Bautista, Christian T.; Garuchava, Natalia; Chubinidze, Svetlana; Tsertsvadze, Ekaterine; Broladze, Mariam; Chitadze, Nazibrola; Sidamonidze, Ketevan; Tsanava, Shota; Akhvlediani, Tamar; Rivard, Robert G.; Mody, Rupal; Hepburn, Matthew J.; Elzer, Philip H.; Nikolich, Mikeljon P.

    2015-01-01

    Background Brucellosis is considered as endemic zoonotic disease in the country of Georgia. However, the burden of the disease on a household level is not known. Therefore, this study sought to determine the benefits of active surveillance coupled to serological screening for the early detection of brucellosis among close contacts of brucellosis cases. Methods We used an active surveillance approach to estimate the rate of seropositivity among household family members and neighboring communit...

  14. Detection rates of geckos in visual surveys: Turning confounding variables into useful knowledge

    Science.gov (United States)

    Lardner, Bjorn; Rodda, Gordon H.; Yackel Adams, Amy A.; Savidge, Julie A.; Reed, Robert N.

    2016-01-01

    Transect surveys without some means of estimating detection probabilities generate population size indices prone to bias because survey conditions differ in time and space. Knowing what causes such bias can help guide the collection of relevant survey covariates, correct the survey data, anticipate situations where bias might be unacceptably large, and elucidate the ecology of target species. We used negative binomial regression to evaluate confounding variables for gecko (primarily Hemidactylus frenatus and Lepidodactylus lugubris) counts on 220-m-long transects surveyed at night, primarily for snakes, on 9,475 occasions. Searchers differed in gecko detection rates by up to a factor of six. The worst and best headlamps differed by a factor of at least two. Strong winds had a negative effect potentially as large as those of searchers or headlamps. More geckos were seen during wet weather conditions, but the effect size was small. Compared with a detection nadir during waxing gibbous (nearly full) moons above the horizon, we saw 28% more geckos during waning crescent moons below the horizon. A sine function suggested that we saw 24% more geckos at the end of the wet season than at the end of the dry season. Fluctuations on a longer timescale also were verified. Disturbingly, corrected data exhibited strong short-term fluctuations that covariates apparently failed to capture. Although some biases can be addressed with measured covariates, others will be difficult to eliminate as a significant source of error in longterm monitoring programs.

  15. A Spitzer survey of mid-infrared molecular emission from protoplanetary disks I: Detection rates

    CERN Document Server

    Pontoppidan, Klaus M; Blake, Geoffrey A; Meijerink, Rowin; Carr, John S; Najita, Joan

    2010-01-01

    We present a Spitzer InfraRed Spectrometer search for 10-36 micron molecular emission from a large sample of protoplanetary disks, including lines from H2O, OH, C2H2, HCN and CO2. This paper describes the sample and data processing and derives the detection rate of mid-infrared molecular emission as a function of stellar mass. The sample covers a range of spectral type from early M to A, and is supplemented by archival spectra of disks around A and B stars. It is drawn from a variety of nearby star forming regions, including Ophiuchus, Lupus and Chamaeleon. In total, we identify 22 T Tauri stars with strong mid-infrared H2O emission. Integrated water line luminosities, where water vapor is detected, range from 5x10^-4 to 9x10^-3 Lsun, likely making water the dominant line coolant of inner disk surfaces in classical T Tauri stars. None of the 5 transitional disks in the sample show detectable gaseous molecular emission with Spitzer upper limits at the 1% level in terms of line-to-continuum ratios (apart from H...

  16. Early pest detection in soy plantations from hyperspectral measurements: a case study for caterpillar detection

    Science.gov (United States)

    Tailanián, Matías; Castiglioni, Enrique; Musé, Pablo; Fernández Flores, Germán.; Lema, Gabriel; Mastrángelo, Pedro; Almansa, Mónica; Fernández Liñares, Ignacio; Fernández Liñares, Germán.

    2015-10-01

    Soybean producers suffer from caterpillar damage in many areas of the world. Estimated average economic losses are annually 500 million USD in Brazil, Argentina, Paraguay and Uruguay. Designing efficient pest control management using selective and targeted pesticide applications is extremely important both from economic and environmental perspectives. With that in mind, we conducted a research program during the 2013-2014 and 2014-2015 planting seasons in a 4,000 ha soybean farm, seeking to achieve early pest detection. Nowadays pest presence is evaluated using manual, labor-intensive counting methods based on sampling strategies which are time consuming and imprecise. The experiment was conducted as follows. Using manual counting methods as ground-truth, a spectrometer capturing reflectance from 400 to 1100 nm was used to measure the reflectance of soy plants. A first conclusion, resulting from measuring the spectral response at leaves level, showed that stress was a property of plants since different leaves with different levels of damage yielded the same spectral response. Then, to assess the applicability of unsupervised classification of plants as healthy, biotic-stressed or abiotic-stressed, feature extraction and selection from leaves spectral signatures, combined with a Supported Vector Machine classifier was designed. Optimization of SVM parameters using grid search with cross-validation, along with classification evaluation by ten-folds cross-validation showed a correct classification rate of 95%, consistently on both seasons. Controlled experiments using cages with different numbers of caterpillars--including caterpillar-free plants--were also conducted to evaluate consistency in trends of the spectral response as well as the extracted features.

  17. A case mix simulation decision support system model for negotiating hospital rates.

    Science.gov (United States)

    Hatcher, M E; Connelly, C

    1988-12-01

    The institution of prospective payment systems by many health care insurers has drawn increased attention to case-based financial planning in hospitals. When hospital revenues are directly linked to patient diagnoses rather than to the types and quantities of services supplied to patients, managers must be aware of the financial implications of different case mixes and must be prepared to influence insurers' price structures. A case-based financial planning model is presented here for the purpose of assisting managerial decision making in the strategic areas of case mix planning and pricing. The computerized model characterizes hospitals as product manufacturers, the product being discharged patients. Diagnosis serves to differentiate the "products"; however, diagnoses are grouped by payor and similar treatment cost experiences to create a limited set of managerially meaningful case types. Diagnostic and treatment costs are also aggregated to facilitate the modeling of the hospital production process. The computerized model projects the number of patients of each case-type and total patient volume, based on estimated patient volume growth rates. The model also projects prices and contribution margins for each case-type, as well as total contribution to hospital overhead. Testing the model with a hypothetical example of a hospital strategic planning problem demonstrates the model's potential as a decision-making aid in case mix planning and case-type pricing. It also reveals several model shortcomings that require further developmental effort. PMID:3148679

  18. Detection of changes in the fractal scaling of heart rate and speed in a marathon race

    Science.gov (United States)

    Billat, Véronique L.; Mille-Hamard, Laurence; Meyer, Yves; Wesfreid, Eva

    2009-09-01

    The aim of this study was to detect changes in the fractal scaling behavior of heart rate and speed fluctuations when the average runner’s speed decreased with fatigue. Scaling analysis in heart rate (HR) and speed (S) dynamics of marathon runners was performed using the detrended fluctuation analysis (DFA) and the wavelet based structure function. We considered both: the short-range ( α1) and the long-range ( α2) scaling exponents for the DFA method separated by a change-point, n0=64=5.3 min (box length), the same for all the races. The variability of HR and S decreased in the second part of the marathon race, while the cardiac cost time series (i.e. the number of cardiac beats per meter) increased due to the decreasing speed behavior. The scaling exponents α1 and α2 of HR and α1 of S, increased during the race ( pexercise on the heart rate and speed variability.

  19. Sensor fusion for antipersonnel landmine detection, a case study

    NARCIS (Netherlands)

    Breejen, E. den; Schutte, K.; Cremer, F.

    1999-01-01

    In this paper the multi sensor fusion results obtained within the European research project GEODE (Ground Explosive Ordnance Detection system) are presented. The lay out of the test lane and the individual sensors used are described. The implementation of the SCOOP algorithm improves the ROC curves,

  20. A case of cardiac sudden death related to abnormality of sympathetic nervous disturbance detected by 123I-metaiodobenzylguanidine (MIBG)

    International Nuclear Information System (INIS)

    A case of cardiac sudden death was reported. A female, 64 years old patient with multiple myeloma had been treated with total dose of 790 mg of adriamycin. Although treadmill examination, dobutamine-loaded cardiac echography and thallium-loaded myocardial scintigraphy gave normal findings, Holter ECG revealed bigeminy and discontinuous ventricular tachycardia. Mexiletine was not tolerated. 123I-MIBG image gave deficit of lateral to posterior wall and increased washing rate of 65%. At 36 days after hospitalization, the ventricular tachycardia changed to fatal fibrillation. The sympathetic nervous disturbance detected by the enhanced washing rate of 123I-MIBG might have participated in the death. (K.H.)

  1. From b → sγ to the LSP detection rates in minimal string unification models

    International Nuclear Information System (INIS)

    We exploit the measured branching ratio for b → sγ to derive lower limits on the sparticle and Higgs masses in the minimal string unification models. For the LSP ('bino'), chargino and the lightest Higgs, these turn out to be 50, 90 and 75 GeV respectively. Taking account of the upper bounds on the mass spectrum from the LSP relic abundance, we estimate the direct detection rate for the latter to vary from 10-1 to 10-4 events/kg/day. The muon flux, produced by neutrinos from the annihilating LSP's, varies in the range 10-2 - 10-9 muons/m2/day. (author). 26 refs, 9 figs

  2. Signal detection and threshold modeling of confidence-rating ROCs: A critical test with minimal assumptions.

    Science.gov (United States)

    Kellen, David; Klauer, Karl Christoph

    2015-07-01

    An ongoing discussion in the recognition-memory literature concerns the question of whether recognition judgments reflect a direct mapping of graded memory representations (a notion that is instantiated by signal detection theory) or whether they are mediated by a discrete-state representation with the possibility of complete information loss (a notion that is instantiated by threshold models). These 2 accounts are usually evaluated by comparing their (penalized) fits to receiver operating characteristic data, a procedure that is predicated on substantial auxiliary assumptions, which if violated can invalidate results. We show that the 2 accounts can be compared on the basis of critical tests that invoke only minimal assumptions. Using previously published receiver operating characteristic data, we show that confidence-rating judgments are consistent with a discrete-state account. (PsycINFO Database Record PMID:26120910

  3. Polyp detection rates using magnification with narrow bandimaging and white light

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    AIM To compare the yield of adenomas betweennarrow band imaging and white light when using highdefinition/magnification.METHODS: This prospective, non-randomized comparativestudy was performed at the endoscopy unit ofveteran affairs medical center in Phoenix, Arizona.Consecutive patients undergoing first average riskcolorectal cancer screening colonoscopy were selected.Two experienced gastroenterologists performed all theprocedures that were blinded to each other's findings.Demographic details were recorded. Data are presentedas mean ± SEM. Proportional data were comparedusing the χ 2 test and means were compared using theStudent's t test. Tandem colonoscopy was performedin a sequential and segmental fashion using one of 3strategies: white light followed by narrow band imaging[Group A: white light (WL) → narrow band imaging(NBI)]; narrow band imaging followed by white light(Group B: NBI → WL) and, white light followed by whitelight (Group C: WL → WL). Detection rate of missedpolyps and adenomas were evaluated in all threegroups.RESULTS: Three hundred patients were studied(100 in each Group). Although the total time for thecolonoscopy was similar in the 3 groups (23.8 ± 0.7,22.2 ± 0.5 and 24.1 ± 0.7 min for Groups A, B and C,respectively), it reached statistical significance betweenGroups B and C (P 〈 0.05). The cecal intubation timein Groups B and C was longer than for Group A (6.5± 0.4 min and 6.5 ± 0.4 min vs 4.9 ± 0.3 min; P 〈0.05). The withdrawal time for Groups A and C waslonger than Group B (18.9 ± 0.7 min and 17.6 ± 0.6 min vs 15.7 ± 0.4 min; P 〈 0.05). Overall miss rate forpolyps and adenomas detected in three groups duringthe second look was 18% and 17%, respectively (P= NS). Detection rate for polyps and adenomas afterfirst look with white light was similar irrespective of thelight used during the second look (WL → WL: 13.7%for polyps, 12.6% for adenomas; WL → NBI: 14

  4. Probabilistic pipe fracture evaluations for applications to leak-rate detection

    International Nuclear Information System (INIS)

    Stochastic pipe fracture evaluations are conducted for applications to leak-rate detection. A state-of-the-art review was first conducted to evaluate the adequacy of current deterministic models for thermo-hydraulic and elastic-plastic fracture analyses. Then a new probabilistic model was developed with the above deterministic models for structural reliability analysis of cracked piping systems and statistical characterization of crack morphology parameters, material properties of pipe, and crack location. The proposed models are then applied for computing conditional probability of failure for various nuclear piping systems in BWR and PWR plants. The PRAISE code was not used, and the probabilistic model is based on modern methods of stochastic mechanics, computationally far superior to Monte Carlo and Stratified Sampling methods used in PRAISE. 10 refs., 9 figs., 1 tab

  5. Direct Detection of Oil; Case History From Iran

    International Nuclear Information System (INIS)

    Iran is one of the main petroleum producers and also one of the countries which experiences contemporary geophysical techniques in Middle East region. Main aim of this study is direct detection of oil hydrocarbons by a special geophysical technique. To accomplish that, FEM, TEM and IP integrated geophysical techniques were successfully applied to measure IP phase shift which might relate to existence of oil traps. Target penetration for this prospecting is about 6 kms

  6. Signal Detection in High Dimension: The Multispiked Case

    OpenAIRE

    Onatski, Alexei; Moreira, Marcelo J.; Hallin, Marc

    2012-01-01

    This paper applies Le Cam’s asymptotic theory of statistical experiments to the signal detection problem in high dimension. We consider the problem of testing the null hypothesis of sphericity of a high-dimensional covariance matrix against an alternative of (unspecified) multiple symmetry-breaking directions (multispiked alternatives). Simple analytical expressions for the Gaussian asymptotic power envelope and the asymptotic powers of previously proposed tests are derived. Those asymptotic ...

  7. Detection of the oxygen consumption rate of migrating zebrafish by electrochemical equalization systems.

    Science.gov (United States)

    Yasukawa, Tomoyuki; Koide, Masahiro; Tatarazako, Norihisa; Abe, Ryoko; Shiku, Hitoshi; Mizutani, Fumio; Matsue, Tomokazu

    2014-01-01

    A novel measurement system to determine oxygen consumption rates via respiration in migrating Zebrafish (Danio rerio) has been developed. A signal equalization system was adapted to detect oxygen in a chamber with one fish, because typical electrochemical techniques cannot measure respiration activities for migrating organisms. A closed chamber was fabricated using a pipet tip attached to a Pt electrode, and a columnar Vycor glass tip was used as the salt bridge. Pt electrode, which was attached to the chamber with one zebrafish, and Ag electrode were immersed in 10 mM potassium iodide (KI), and both the electrodes were connected externally to form a galvanic cell. Pt and Ag electrodes act as the cathode and anode to reduce oxygen and oxidize silver, respectively, allowing the deposition of insoluble silver iodide (AgI). The AgI acts as the signal source accumulated on the Ag electrode by conversion of oxygen. The amount of AgI deposited on the Ag electrode was determined by cathodic stripping voltammetry. The presence of zebrafish or its embryo led to a decrease in the stripping currents generated by a 10 min conversion of oxygen to AgI. The conversion of oxygen to AgI is disturbed by the migration of the zebrafish and allows the detection of different equalized signals corresponding to respiration activity. The oxygen consumption rates of the zebrafish and its embryo were estimated and determined to be ∼4.1 and 2.4 pmol·s(-1), respectively. The deposited AgI almost completely disappeared with a single stripping process. The signal equalization system provides a method to determine the respiration activities for migrating zebrafish and could be used to estimate environmental risk and for effective drug screening. PMID:24328209

  8. Strong comovements of exchange rates: Theoretical and empirical cases when currencies become the same asset

    OpenAIRE

    Kühl, Michael

    2008-01-01

    The aim of this paper is to detect periods in which two currencies can be classified as being the ”same” asset. Two currencies can be treated as the same asset if their exchange rates vis-`a-vis the same base currency are cointegrated with a cointegration vector that is consistent with the triangular arbitrage condition. In a first step, it is theoretically derived under which conditions, with respect to the process of the fundamentals, the exchange rates are cointegrated. The empirical resul...

  9. Rates of Detection of Mood and Anxiety Disorders in Primary Care: A Descriptive, Cross-Sectional Study

    OpenAIRE

    Vermani, Monica; Marcus, Madalyn; Katzman, Martin A

    2011-01-01

    Objective: To determine the incidence of major depressive disorder, bipolar disorder, panic disorder, social anxiety disorder, and generalized anxiety disorder and to assess their detection rates in the Canadian primary care setting.

  10. Time of day variation in polyp detection rate for colonoscopies performed on a 3-hour shift schedule.

    LENUS (Irish Health Repository)

    Munson, Gregory W

    2011-03-01

    Recent research suggests that the colonoscopy polyp detection rate (PDR) varies by time of day, possibly because of endoscopist fatigue. Mayo Clinic Rochester (MCR) schedules colonoscopies on 3-hour shifts, which should minimize fatigue.

  11. Theoretical direct WIMP detection rates for transitions to nuclear excited states

    CERN Document Server

    Vergados, J D; Pirinen, P; Srivastava, P C; Kortelainen, M; Suhonen, J

    2015-01-01

    The recent WMAP and Planck data have confirmed that exotic dark matter together with the vacuum energy (cosmological constant) dominate in the flat Universe. Many extensions of the standard model provide dark matter candidates, in particular Weakly Interacting Massive Particles (WIMPs). Thus the direct dark matter detection is central to particle physics and cosmology. Most of the research on this issue has hitherto focused on the detection of the recoiling nucleus. In this paper we study transitions to the excited states, possible in some nuclei, which have sufficiently low lying excited states. Examples considered previously were the first excited states of $^{127}$I and $^{129}$Xe. We examine here $^{83}$Kr, which offers some kinematical advantages and is currently considered as a possible target. We find appreciable branching ratios for the inelastic scattering mediated by the spin cross sections, with an inelastic event rate of $4.4\\times 10^{-4}$kg$^{-1}$d$^{-1}$. So, the extra signature of the gamma ra...

  12. Research into Plagiarism Cases and Plagiarism Detection Methods

    OpenAIRE

    Kashkur, M; Paršutins, S; Borisovs, A

    2010-01-01

    In the age of information technology intellectual property becomes especially valuable. This is one of the causes why the cases of the plagiarism appear more frequently in all vital sectors. Due to that, there is a growing need for different instruments for the protection and verification of copyright for finding plagiarism. Before checking the document for plagiarism, reviewing algorithms and approaches for searching plagiarism, you must know and understand what constitutes the plagiarism. T...

  13. Illegal hunting cases detected with molecular forensics in Brazil

    Directory of Open Access Journals (Sweden)

    Sanches Alexandra

    2012-08-01

    Full Text Available Abstract Background Illegal hunting is one of the major threats to vertebrate populations in tropical regions. This unsustainable practice has serious consequences not only for the target populations, but also for the dynamics and structure of tropical ecosystems. Generally, in cases of suspected illegal hunting, the only evidence available is pieces of meat, skin or bone. In these cases, species identification can only be reliably determined using molecular technologies. Here, we reported an investigative study of three cases of suspected wildlife poaching in which molecular biology techniques were employed to identify the hunted species from remains of meat. Findings By applying cytochrome b (cyt-b and cytochrome oxidase subunit I (COI molecular markers, the suspected illegal poaching was confirmed by the identification of three wild species, capybara (Hydrochoerus hydrochaeris, Chaco Chachalaca (Ortalis canicollis and Pampas deer (Ozotoceros bezoarticus. In Brazil, hunting is a criminal offense, and based on this evidence, the defendants were found guilty and punished with fines; they may still be sentenced to prison for a period of 6 to 12 months. Conclusions The genetic analysis used in this investigative study was suitable to diagnose the species killed and solve these criminal investigations. Molecular forensic techniques can therefore provide an important tool that enables local law enforcement agencies to apprehend illegal poachers.

  14. Indirect detection analysis: wino dark matter case study

    International Nuclear Information System (INIS)

    We perform a multichannel analysis of the indirect signals for the Wino Dark Matter, including one-loop electroweak and Sommerfeld enhancement corrections. We derive limits from cosmic ray antiprotons and positrons, from continuum galactic and extragalactic diffuse γ-ray spectra, from the absence of γ-ray line features at the galactic center above 500 GeV in energy, from γ-rays toward nearby dwarf spheroidal galaxies and galaxy clusters, and from CMB power-spectra. Additionally, we show the future prospects for neutrino observations toward the inner Galaxy and from antideuteron searches. For each of these indirect detection probes we include and discuss the relevance of the most important astrophysical uncertainties that can impact the strength of the derived limits. We find that the Wino as a dark matter candidate is excluded in the mass range bellow ≅ 800 GeV from antiprotons and between 1.8 and 3.5 TeV from the absence of a γ-ray line feature toward the galactic center. Limits from other indirect detection probes confirm the main bulk of the excluded mass ranges

  15. The Impact of Treasury Bill Rate and Interest Rate On The Stock Market Returns: Case Of Ghana Stock Exchange

    OpenAIRE

    Augustine  Addo; Fidelis Sunzuoye

    2013-01-01

    Several studies have suggested that macroeconomic variables affect Stock market returns using Treasury bill rate as a measure of interest rate. The study examines the joint impact of  interest rates and Treasury bill rate on  stock market returns on Ghana Stock Exchange over the period between January 1995 and December 2011. Using Johansen’s Multivariate Cointegration Model and Vector Error  Correction Model the study establish that there is cointegration between Interest rate, Treasury bill ...

  16. Positive predictive value of device-detected atrial high-rate episodes at different rates and durations

    DEFF Research Database (Denmark)

    Kaufman, Elizabeth S; Israel, Carsten W; Nair, Girish M;

    2012-01-01

    oral anticoagulation, it is crucial to understand the relationship between AHREs and true AT/AF. OBJECTIVE: To compare the positive predictive value of AHREs for electrogram-confirmed AT/AF for various atrial rates and episode durations. METHODS: By using data from 2580 patients who participated in the...... ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the AF Reduction atrial pacing Trial, all AHREs >6 minutes and >190 beats/min with available electrograms were reviewed to determine whether they represented true AT/AF. The positive predictive value of these AHREs was assessed...... for episode durations of 6 minutes, 30 minutes, 6 hours, and 24 hours at atrial rates of 190 and 250 beats/min. RESULTS: Of 5769 AHREs >6 minutes and >190 beats/min, 82.7% were true AT/AF and 17.3% were false positives (predominantly due to repetitive non-re-entrant ventriculoatrial synchrony). False...

  17. The Seascale childhood leukaemia cases - the mutation rates implied by paternal preconceptional radiation doses

    International Nuclear Information System (INIS)

    Recent studies have demonstrated that paternal preconceptional radiation exposure is an insufficient explanation of the excess of leukaemia cases among children born in the West Cumbrian village of Seascale. Less than 10% of the children whose fathers were employed at the Sellafield nuclear installation and received a dose of radiation prior to their conception were born in Seascale; but the statistical association between paternal preconceptional radiation dose and leukaemia is apparent only in these Seascale-born children. This paper explores the speculative proposition that the Seascale leukaemia cases are caused by a strong interaction between paternal preconceptional irradiation and exposure after conception to a specific co-factor which is confined to Seascale. This hypothesis is demonstrated to be biologically implausible, the implied rate of transmitted radiation-induced leukaemogenic mutations being far beyond the established rates for hereditary effects. (Author)

  18. Case fatality ratio and mortality rate trends of community-onset Staphylococcus aureus bacteraemia

    DEFF Research Database (Denmark)

    Tom, S; Galbraith, J C; Valiquette, L;

    2014-01-01

    Lethal outcomes can be expressed as a case fatality ratio (CFR) or as a mortality rate per 100 000 population per year (MR). Population surveillance for community-onset methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus bacteraemia was conducted in Canada, Austral......-onset S. aureus bacteraemia, particularly MSSA, is associated with major disease burden. This study highlights complementary information provided by evaluating both CFR and MR.......Lethal outcomes can be expressed as a case fatality ratio (CFR) or as a mortality rate per 100 000 population per year (MR). Population surveillance for community-onset methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus bacteraemia was conducted in Canada, Australia...

  19. Are electricity prices affected by the US dollar to Euro exchange rate? The Spanish case

    International Nuclear Information System (INIS)

    The objective of this paper is to investigate the relationships between Spanish electricity spot prices and the US dollar/Euro (USD/Euro) exchange rate during the period 2005-2007, taking into account the study of the association between dollar and oil prices, in order to better understand the evolution of the former over time. The first finding in this study is that Spanish electricity spots prices, the USD/Euro exchange rate and oil prices are cointegrated; therefore there is a long-run equilibrium relationship between the three variables. Short-run relationships have been detected between oil prices and Spanish electricity prices and USD/Euro exchange rate in the sense that Spanish electricity prices and USD/Euro exchange rate are affected by oil prices in the short run. There is a transmission of volatility between USD/Euro exchange rate and oil prices to Spanish electricity prices; so although Spanish electricity prices are not affected in level by the movements of USD/Euro exchange rate, they are in volatility. In this kind of scenario the conclusions confirm that for countries so dependent on external causes as Spain, one possible solution for guarantying the energy security would be the promotion of the renewable energies. Therefore we cannot ignore the impact in the internal expenses of the cost of installation and generation of green energies so there must be a balance between the increase in renewables and the reasonable market price of the electricity. (author)

  20. Are electricity prices affected by the US dollar to Euro exchange rate? The Spanish case

    Energy Technology Data Exchange (ETDEWEB)

    Munoz, M. Pilar [Department of Statistics and Operations Research, Universitat Politecnica de Catalunya, Jordi Girona, 1-3. 08034 Barcelona (Spain); Dickey, David A. [Department of Statistics, North Carolina State University, 2311 Stinson Drive, Raleigh, NC 27695-8203 (United States)

    2009-11-15

    The objective of this paper is to investigate the relationships between Spanish electricity spot prices and the US dollar/Euro (USD/Euro) exchange rate during the period 2005-2007, taking into account the study of the association between dollar and oil prices, in order to better understand the evolution of the former over time. The first finding in this study is that Spanish electricity spots prices, the USD/Euro exchange rate and oil prices are cointegrated; therefore there is a long-run equilibrium relationship between the three variables. Short-run relationships have been detected between oil prices and Spanish electricity prices and USD/Euro exchange rate in the sense that Spanish electricity prices and USD/Euro exchange rate are affected by oil prices in the short run. There is a transmission of volatility between USD/Euro exchange rate and oil prices to Spanish electricity prices; so although Spanish electricity prices are not affected in level by the movements of USD/Euro exchange rate, they are in volatility. In this kind of scenario the conclusions confirm that for countries so dependent on external causes as Spain, one possible solution for guarantying the energy security would be the promotion of the renewable energies. Therefore we cannot ignore the impact in the internal expenses of the cost of installation and generation of green energies so there must be a balance between the increase in renewables and the reasonable market price of the electricity. (author)

  1. Heart rate variability analysis in postural orthostatic tachycardia syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Raffaele Calabrò

    2006-09-01

    Full Text Available The authors present a case of 36 year old male patient with idiopathic postural orthostatic tachycardia syndrome (POTS diagnosed during head-up tilt testing. Power spectral analysis of heart rate variability (HRV during the tilt test revealed that the ratio of low and high frequency powers (LF/HF increased with the onset of orthostatic intolerance. This analysis confirmed in our patient a strong activation in sympathetic tone.

  2. Heart Rate Variability based Classification of Normal and Hypertension Cases by Linear-nonlinear Method

    Directory of Open Access Journals (Sweden)

    M. G. Poddar

    2014-11-01

    Full Text Available The aim of this study is to analyse and compare the heart rate variability (HRV of normal and hypertension cases using time domain, frequency domain, and nonlinear methods. For short term HRV analysis, a five-minute electrocardiogram (ECG of 57 normal and 56 hypertension subjects were recorded with prior verification of their clinical status by a cardiologist. Most time domain features of hypertension cases have clearly reduced values over normal subjects, frequency domain features, like power in different spectral bands, also have the distinguishable decreased values, whereas sympathovagal balance has clear edge over hypertension cases than normal cases. Nonlinear parameters of Poincare plot, approximate entropy and sample entropy, have higher values in normal cases when compared with hypertension cases. Support vector machine-based binary system classifies these two classes with 100 per cent accuracy and 100 per cent sensitivity when all time domain, frequency domain, and nonlinear features were used. It may work as a better predictor for in patients with hypertension.Science Journal, Vol. 64, No. 6, November 2014, pp.542-548, DOI:http://dx.doi.org/10.14429/dsj.64.7867

  3. The Impact of Treasury Bill Rate and Interest Rate On The Stock Market Returns: Case Of Ghana Stock Exchange

    Directory of Open Access Journals (Sweden)

    Augustine  Addo

    2013-10-01

    Full Text Available Several studies have suggested that macroeconomic variables affect Stock market returns using Treasury bill rate as a measure of interest rate. The study examines the joint impact of  interest rates and Treasury bill rate on  stock market returns on Ghana Stock Exchange over the period between January 1995 and December 2011. Using Johansen’s Multivariate Cointegration Model and Vector Error  Correction Model the study establish that there is cointegration between Interest rate, Treasury bill rate and stock market returns indicating long run relationship. On the basis of the Multiple Regression Analysis (OLS carried out by Eviews 7 program, the results show that Treasury bill rate and interest rate both have a negative relationship with stock market returns but  are not  significant. These results lend support to the idea that interest rate and Treasury bill rate has both  negative  relationship  but  weak predictive  power on stock market returns independently. The study conclude that interest rate and Treasury bill rate jointly impact on stock market returns in the long run. Understanding the effects of both  Treasury bill rate and interest rate dynamics on stock market returns will help investors, fund  and portfolio managers and firms make better investment decisions.

  4. Intrusion Prevention and Detection in Grid Computing - The ALICE Case

    CERN Document Server

    Gomez, Andres; Kebschull, Udo

    2015-01-01

    Grids allow users flexible on-demand usage of computing resources through remote communication networks. A remarkable example of a Grid in High Energy Physics (HEP) research is used in the ALICE experiment at European Organization for Nuclear Research CERN. Physicists can submit jobs used to process the huge amount of particle collision data produced by the Large Hadron Collider (LHC). Grids face complex security challenges. They are interesting targets for attackers seeking for huge computational resources. Since users can execute arbitrary code in the worker nodes on the Grid sites, special care should be put in this environment. Automatic tools to harden and monitor this scenario are required. Currently, there is no integrated solution for such requirement. This paper describes a new security framework to allow execution of job payloads in a sandboxed context. It also allows process behavior monitoring to detect intrusions, even when new attack methods or zero day vulnerabilities are exploited, by a Machin...

  5. Microbubbles detection during cardiopulmonary bypass with transoesophageal echocardiography: a case report

    OpenAIRE

    Zanatta, Paolo; Bosco, Enrico; Salandin, Valeria; Salvador, Loris; Valfrè, Carlo; Sorbara, Carlo

    2008-01-01

    Introduction Microembolic signals are usually detected with transcranial doppler during cardiac surgery. This report focuses on suggesting the transesophageal echocardiography as a different diagnostic approach to detect microemboli during cardiopulmonary bypass. Case presentation A 58 year old male patient, caucasian race, was operated on video assisted minimally invasive mitral valve repair using right minithoracotomy approach. His past medical history included an uncontrolled hypertension,...

  6. Malaria incidence in children in South-West Burkina Faso: comparison of active and passive case detection methods.

    Directory of Open Access Journals (Sweden)

    Alfred B Tiono

    Full Text Available BACKGROUND: The aim of this study was to determine the incidence and seasonal pattern of malaria in children in South-West Burkina Faso, and to compare, in a randomized trial, characteristics of cases detected by active and passive surveillance. This study also enabled the planning of a malaria vaccine trial. METHODS: Households with young children, located within 5 kilometers of a health facility, were randomized to one of two malaria surveillance methods. In the first group, children were monitored actively. Each child was visited twice weekly; tympanic temperature was measured, and if the child had a fever or history of fever, a malaria rapid diagnostic test was performed and a blood smear collected. In the second group, children were monitored passively. The child's parent or caregiver was asked to bring the child to the nearest clinic if he was unwell. Follow up lasted 13 months from September 2009. RESULTS: Incidence of malaria (Fever with parasitaemia ≥5,000/µL was 1.18 episodes/child/year in the active cohort and 0.89 in the passive cohort (rate ratio 1.32, 95% CI 1.13-1.54. Malaria cases in the passive cohort were more likely to have high grade fever; but parasite densities were similar in the two groups. Incidence was highly seasonal; when a specific case definition was used, about 60% of cases occurred within the 4 months June-September. CONCLUSION: Passive case detection required at least a 30%-40% increase in the sample size for vaccine trials, compared to active detection, to achieve the same power. However we did not find any evidence that parasite densities were higher with passive than with active detection. The incidence of malaria is highly seasonal and meets the WHO criteria for Seasonal Malaria Chemoprevention (SMC. At least half of the malaria cases in these children could potentially be prevented if SMC was effectively deployed.

  7. Impaired face detection may explain some but not all cases of developmental prosopagnosia.

    Science.gov (United States)

    Dalrymple, Kirsten A; Duchaine, Brad

    2016-05-01

    Developmental prosopagnosia (DP) is defined by severe face recognition difficulties due to the failure to develop the visual mechanisms for processing faces. The two-process theory of face recognition (Morton & Johnson, 1991) implies that DP could result from a failure of an innate face detection system; this failure could prevent an individual from then tuning higher-level processes for face recognition (Johnson, 2005). Work with adults indicates that some individuals with DP have normal face detection whereas others are impaired. However, face detection has not been addressed in children with DP, even though their results may be especially informative because they have had less opportunity to develop strategies that could mask detection deficits. We tested the face detection abilities of seven children with DP. Four were impaired at face detection to some degree (i.e. abnormally slow, or failed to find faces) while the remaining three children had normal face detection. Hence, the cases with impaired detection are consistent with the two-process account suggesting that DP could result from a failure of face detection. However, the cases with normal detection implicate a higher-level origin. The dissociation between normal face detection and impaired identity perception also indicates that these abilities depend on different neurocognitive processes. PMID:25959299

  8. The clinical significance of detection to heart rate deceleration capacity and heart rate variability in patients with chronic heart failure

    Directory of Open Access Journals (Sweden)

    Jiang-rong Zhou

    2015-01-01

    Full Text Available Objective: To study the change of heart rate deceleration capacity ( DC and heart rate variability in patients with chronic heart failure (CHF and its relationship with left ventricular ejection fraction (LVEF. Methods: DC, LVEF, time and frequency domain parameters of HRV were measured in 66 patients with CHF and 34 healthy adults (control group by using 24h Holter recordings and Echocardiography. The standard deviation of normal R-R intervals( SDNN, squares of differences between adjacent NN intervals ( RMSSD,low frequency power( LFn and high frequency power( HFn and the changes of LVEF were compared between  the two groups,the relationship between DC,LVEF and HRV were studied in patients with CHF. Results: The median value of DC in the patients with CHF was significantly lower than that in control group( 3.1 ± 2.4 ms vs 7.2 ± 1.3 ms,P <0.01.Incidence of abnormal DC in the CHF group was 57.5%,which was significantly higher than that in the control group (P <0.01.The HRV index, including SDNN、RMSSD、LFn、HFn, in the CHF group was significantly lower than that in normal control group (P < 0.01. Significant positive correlation between HRV index and LVEF were confirmed (P < 0.01. Conclusions: DC and HRV index are lower in patients with CHF and have a good correlation with the left ventricular ejection fraction.

  9. Lifeline electric rates and alternative approaches to the problems of low-income ratepayers. Ten case studies of implemented programs

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    Program summaries, issue developments, governmental processes, and impacts are discussed for 10 case studies dealing with lifeline electric rates and alternative approaches to the problems of low-income ratepayers, namely; the Boston Edison rate freeze; the California lifeline; Florida Power and Light conservation rate; the Iowa-Illinois Gas and Electric small-use rate; the Maine demonstration lifeline program; the Massachusetts Electric Company A-65 rate; the Michigan optional senior citizen rate; the Narragansett Electric Company A-65 SSI rate; the Northern States Power Company conservation rate break; and the Potomac Electric Power Company rate freeze. (MCW)

  10. Another short-burst host galaxy with an optically obscured high star formation rate: The case of GRB 071227

    International Nuclear Information System (INIS)

    We report on radio continuum observations of the host galaxy of the short gamma-ray burst 071227 (z = 0.381) with the Australia Telescope Compact Array. We detect the galaxy in the 5.5 GHz band with an integrated flux density of F ν = 43 ± 11 μJy, corresponding to an unobscured star-formation rate of about 24 M ☉ yr–1, 40 times higher than what was found from optical emission lines. Among the ∼30 well-identified and studied host galaxies of short bursts this is the third case where the host is found to undergo an episode of intense star formation. This suggests that a fraction of all short-burst progenitors hosted in star-forming galaxies could be physically related to recent star formation activity, implying a relatively short merger timescale.

  11. Another short-burst host galaxy with an optically obscured high star formation rate: The case of GRB 071227

    Energy Technology Data Exchange (ETDEWEB)

    Nicuesa Guelbenzu, A.; Klose, S.; Kann, D. A.; Rossi, A.; Schmidl, S. [Thüringer Landessternwarte Tautenburg, Sternwarte 5, D-07778 Tautenburg (Germany); Michałowski, M. J.; McKenzie, M. R. G. [Scottish Universities Physics Alliance, Institute for Astronomy, University of Edinburgh, Royal Observatory, Edinburgh, EH9 3HJ (United Kingdom); Savaglio, S.; Greiner, J. [Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstraße, D-85748 Garching (Germany); Hunt, L. K. [INAF-Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy); Gorosabel, J. [Instituto de Astrofísica de Andalucía, Consejo Superior de Investigaciones Científicas (IAA-CSIC), Glorieta de la Astronomía s/n, E-18008 Granada (Spain); Palazzi, E. [INAF-IASF Bologna, Via Gobetti 101, I-40129 Bologna (Italy)

    2014-07-01

    We report on radio continuum observations of the host galaxy of the short gamma-ray burst 071227 (z = 0.381) with the Australia Telescope Compact Array. We detect the galaxy in the 5.5 GHz band with an integrated flux density of F {sub ν} = 43 ± 11 μJy, corresponding to an unobscured star-formation rate of about 24 M {sub ☉} yr{sup –1}, 40 times higher than what was found from optical emission lines. Among the ∼30 well-identified and studied host galaxies of short bursts this is the third case where the host is found to undergo an episode of intense star formation. This suggests that a fraction of all short-burst progenitors hosted in star-forming galaxies could be physically related to recent star formation activity, implying a relatively short merger timescale.

  12. Optimizing convergence rates of alternating minimization reconstruction algorithms for real-time explosive detection applications

    Science.gov (United States)

    Bosch, Carl; Degirmenci, Soysal; Barlow, Jason; Mesika, Assaf; Politte, David G.; O'Sullivan, Joseph A.

    2016-05-01

    X-ray computed tomography reconstruction for medical, security and industrial applications has evolved through 40 years of experience with rotating gantry scanners using analytic reconstruction techniques such as filtered back projection (FBP). In parallel, research into statistical iterative reconstruction algorithms has evolved to apply to sparse view scanners in nuclear medicine, low data rate scanners in Positron Emission Tomography (PET) [5, 7, 10] and more recently to reduce exposure to ionizing radiation in conventional X-ray CT scanners. Multiple approaches to statistical iterative reconstruction have been developed based primarily on variations of expectation maximization (EM) algorithms. The primary benefit of EM algorithms is the guarantee of convergence that is maintained when iterative corrections are made within the limits of convergent algorithms. The primary disadvantage, however is that strict adherence to correction limits of convergent algorithms extends the number of iterations and ultimate timeline to complete a 3D volumetric reconstruction. Researchers have studied methods to accelerate convergence through more aggressive corrections [1], ordered subsets [1, 3, 4, 9] and spatially variant image updates. In this paper we describe the development of an AM reconstruction algorithm with accelerated convergence for use in a real-time explosive detection application for aviation security. By judiciously applying multiple acceleration techniques and advanced GPU processing architectures, we are able to perform 3D reconstruction of scanned passenger baggage at a rate of 75 slices per second. Analysis of the results on stream of commerce passenger bags demonstrates accelerated convergence by factors of 8 to 15, when comparing images from accelerated and strictly convergent algorithms.

  13. Steel Casing Resistivity Technology (SCRT): Innovative Applications of Electrical Methods for Buried Tank Leak Detection

    Science.gov (United States)

    Fink, J. B.; Levitt, M. T.; Gee, G. W.

    2002-12-01

    The need for non-invasive leak detection methods is extremely important for monitoring cleanup efforts of nuclear waste contained in underground storage tanks at the Hanford Nuclear Facility in Washington. Drilling is both very expensive and undesirable in the tank farms. Various geophysical imaging methods were evaluated over the past two years at two "cold" sites but within geologic conditions similar to the tank farms. The "cold" sites consisted of 1. a dense array of 32 steel casings, and 2. a "mock tank" in which various controlled leaks (injections) of a saturated aqueous solution of Na2S2O35H20 were metered. Nearly all methods required invasive drilling for subsurface placement of sensors. An innovative direct-current electrical method using existing infrastructure as grounding electrodes, such as steel casings and steel tanks, has shown very promising results and is undergoing further testing. The most useful results have been obtained by using multiple grounding points for spatial determinations and continuous time-series monitoring for temporal variations. Although the large size of tanks and lengths of casings make discrete volume estimations difficult, data acquired for test leaks to date have shown a surprising correlation between leak rates and the rate-of-change of specific electrical measurements. First order volume approximations can be made based on existing knowledge of the geologic environment and hydraulic parameters. Spatial data provide general leak location and gross flow characteristics, whereas temporal data indicate test leak commencement, cessation, and approximate leak rates. On-going testing is providing quantitative calibration information that is expected to transfer to the tank farm environments. Procedures are being developed that will simplify the installation and operation of the system in the tank-farm environments. Implementation of the technology necessitated remote operation and monitoring of the electrical system

  14. Intrusion Prevention and Detection in Grid Computing - The ALICE Case

    Science.gov (United States)

    Gomez, Andres; Lara, Camilo; Kebschull, Udo

    2015-12-01

    Grids allow users flexible on-demand usage of computing resources through remote communication networks. A remarkable example of a Grid in High Energy Physics (HEP) research is used in the ALICE experiment at European Organization for Nuclear Research CERN. Physicists can submit jobs used to process the huge amount of particle collision data produced by the Large Hadron Collider (LHC). Grids face complex security challenges. They are interesting targets for attackers seeking for huge computational resources. Since users can execute arbitrary code in the worker nodes on the Grid sites, special care should be put in this environment. Automatic tools to harden and monitor this scenario are required. Currently, there is no integrated solution for such requirement. This paper describes a new security framework to allow execution of job payloads in a sandboxed context. It also allows process behavior monitoring to detect intrusions, even when new attack methods or zero day vulnerabilities are exploited, by a Machine Learning approach. We plan to implement the proposed framework as a software prototype that will be tested as a component of the ALICE Grid middleware.

  15. Correlation analysis of EV71 detection and case severity in hand, foot, and mouth disease in the Hunan Province of China.

    Directory of Open Access Journals (Sweden)

    Li-Dong Gao

    Full Text Available An increase in the incidence of hand, foot and mouth disease (HFMD cases has been observed in the Hunan province of mainland China since 2009 with a particularly higher level of severe cases in 2010-2012. Intestinal viruses of the picornaviridae family are responsible for the human syndrome associated with HFMD with enterovirus 71 (EV71 and Coxsackievirus A16 (Cox A16 being the most common causative strains. HFMD cases associated with EV71 are generally more severe with an increased association of morbidity and mortality. In this study, the etiology surveillance data of HFMD cases in Hunan province from March 2010 to October 2012 were analyzed to determine if there is a statistically relevant linear correlation exists between the detection rate of EV71 in mild cases and the proportion of severe cases among all HFMD patients. As the cases progressed from mild to severe to fatal, the likelihood of EV71 detection increased (25.78%, 52.20% and 84.18%, respectively. For all cases in the timeframe evaluated in this study, the presence of virus was detected in 63.21% of cases; among cases showing positivity for virus, EV71 infection accounted for 50.14%. These results provide evidence to support the observed higher morbidity and mortality associated with this outbreak and emphasizes the importance of early detection in order to implement necessary prevention measures to mitigate disease progression.

  16. Determinants of the Final Size and Case Rate of Nosocomial Outbreaks.

    Directory of Open Access Journals (Sweden)

    Amy Hurford

    Full Text Available Different nosocomial pathogen species have varying infectivity and durations of infectiousness, while the transmission route determines the contact rate between pathogens and susceptible patients. To determine if the pathogen species and transmission route affects the size and spread of outbreaks, we perform a meta-analysis that examines data from 933 outbreaks of hospital-acquired infection representing 14 pathogen species and 8 transmission routes. We find that the mean number of cases in an outbreak is best predicted by the pathogen species and the mean number of cases per day is best predicted by the species-transmission route combination. Our fitted model predicts the largest mean number of cases for Salmonella outbreaks (22.3 and the smallest mean number of cases for Streptococci outbreaks (8.5. The largest mean number of cases per day occurs during Salmonella outbreaks spread via the environment (0.33 and the smallest occurs for Legionella outbreaks spread by multiple transmission routes (0.005. When combined with information on the frequency of outbreaks these findings could inform the design of infection control policies in hospitals.

  17. Detection limits for ferrimagnetic particle concentrations using magnetic resonance imaging based proton transverse relaxation rate measurements

    Energy Technology Data Exchange (ETDEWEB)

    Pardoe, H [School of Physics, University of Western Australia, Crawley, Perth, WA 6009 (Australia); Chua-anusorn, W [School of Physics, University of Western Australia, Crawley, Perth, WA 6009 (Australia); Pierre, T G St [School of Physics, University of Western Australia, Crawley, Perth, WA 6009 (Australia); Dobson, J [Department of Biomedical Engineering and Medical Physics, Centre for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB (United Kingdom)

    2003-03-21

    A clinical magnetic resonance imaging (MRI) system was used to measure proton transverse relaxation rates (R{sub 2}) in agar gels with varying concentrations of ferrimagnetic iron oxide nanoparticles in a field strength of 1.5 T. The nanoparticles were prepared by coprecipitation of ferric and ferrous ions in the presence of either dextran or polyvinyl alcohol. The method of preparation resulted in loosely packed clusters (dextran) or branched chains (polyvinyl alcohol) of particles containing of the order of 600 and 400 particles, respectively. For both methods of particle preparation, concentrations of ferrimagnetic iron in agar gel less than 0.01 mg ml{sup -1} had no measurable effect on the value of R{sub 2} for the gel. The results indicate that MRI-based R{sub 2} measurements using 1.5 T clinical scanners are not quite sensitive enough to detect the very low concentrations of nanoparticulate biogenic magnetite reported in human brain tissue. (note)

  18. A case of cerebral cysticercosis detected by computed tomography

    International Nuclear Information System (INIS)

    Cysticercosis is well known as a parasitic infection that commonly affects the central nervous system. A 60-year-old man, who once lived in the mainland of China in the 1940s, was admitted to the hospital complaining of the right motor weakness and speech disturbance. Neurological examinations revealed the right hemiparesis with increase of deep tendon reflexes and motor dysphasia. The skull x-ray films showed no abnormal finding, but many small fusiform calcifications were found in the x-ray films of soft tissues of the limbs. Brain CT demonstrated several small rounded and calcified high density areas and cystic low density areas in the parenchyma with a marked dilatation of the ventricular system. And a large cystic mass of the left fronto-parietal region compressed the body of the left lateral ventricle. After infusion of contrast medium, a small ring-enhanced density area in the frontal region was revealed. By a craniotomy, the large cyst, which had a bluish transparent wall, was totally extirpated. The nature of the cystic content was similar to that of the cerebro-spinal fluid. On histological examination of the cyst wall any scolex was not found, but papillary folds and typical three layers of cysticercosis were observed. The immunological testing for cysticercosis was positive on the serum of the patient. These findings confirmed the diagnosis of human cysticercosis. Wider applications of CT in clinical practice could discover more cases of cysticercosis in the recent situation of world wide communication of population. This report will be the first one of cysticercosis which mainly discussed about the findings of CT in the Japanese literature. (author)

  19. Case of cerebral cysticercosis detected by computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Tomosugi, Tetsuzo; Gondo, Masazumi; Kanamaru, Reizo; Asakura, Tetsuhiko; Mihara, Tadahiro (Kagoshima Univ. (Japan). Faculty of Medicine)

    1983-03-01

    Cysticercosis is well known as a parasitic infection that commonly affects the central nervous system. A 60-year-old man, who once lived in the mainland of China in the 1940s, was admitted to the hospital complaining of the right motor weakness and speech disturbance. Neurological examinations revealed the right hemiparesis with increase of deep tendon reflexes and motor dysphasia. The skull x-ray films showed no abnormal finding, but many small fusiform calcifications were found in the x-ray films of soft tissues of the limbs. Brain CT demonstrated several small rounded and calcified high density areas and cystic low density areas in the parenchyma with a marked dilatation of the ventricular system. And a large cystic mass of the left fronto-parietal region compressed the body of the left lateral ventricle. After infusion of contrast medium, a small ring-enhanced density area in the frontal region was revealed. By a craniotomy, the large cyst, which had a bluish transparent wall, was totally extirpated. The nature of the cystic content was similar to that of the cerebro-spinal fluid. On histological examination of the cyst wall any scolex was not found, but papillary folds and typical three layers of cysticercosis were observed. The immunological testing for cysticercosis was positive on the serum of the patient. These findings confirmed the diagnosis of human cysticercosis. Wider applications of CT in clinical practice could discover more cases of cysticercosis in the recent situation of world wide communication of population. This report will be the first one of cysticercosis which mainly discussed about the findings of CT in the Japanese literature.

  20. Why The Rate Of Financing In Islamic Banks Is High? An Analysis Based On Malaysian Case

    Directory of Open Access Journals (Sweden)

    Irfan Syauqi Beik

    2008-01-01

    Full Text Available Islamic banking has grown rapidly and has become fi nancial-nerve centre in today’s world economy, particularly in the last three decades. It has attracted various entrepreneurs and enterprises to get its fi nancing. However, Islamic banks tend to have a higher rate of fi nancing compared to the conventional ones. This less competitiveness encourage the demand for Islamic products may fall leaving the Islamic banks. Good debtors opted for conventional loans since the interest rates paid were relatively lower and the rest (the bad debtors successfully made their way to Islamic banks. Therefore, the nonperforming financing of Islamic banks is high. This paper attempts to analyze factors that determine high rate of fi nancing in Islamic banks, by taking the case of Malaysian Islamic banks. In this paper, the top three of Islamic banks and conventional banks are selected for comparison. It finds that high default premium and overheads per capital contribute signifi cantly to the high fi nancing rate. Hence, the Islamic banks should diversify their assets and implement universal banking concept.Keywords: Islamic bank, rate of fi nancing, NPF (Non-Performing Financing, universal banking system

  1. Sustainability assessment, rating systems and historical buildings Case study: Rehabilitated construction in a university site

    Directory of Open Access Journals (Sweden)

    Sadrykia Somayeh

    2016-01-01

    Full Text Available This paper explores the relationship between the indicators and different factors that “rating systems for green projects” concentrates on, and principles and factors considered in the rehabilitation of historical buildings. In recent years, different methods and systems concerned and improved for assessing environmental sustainability. LEED (Leadership in Energy and Environmental Design and BREEAM (Building Research Establishment (BRE Environmental Assessment Method are two most commonly used rating systems, established in U.S and UK. These systems comprise some categories and different factors to achieve environmentally responsible design. Firstly, this study focuses on the list of rating systems indicators and criteria. Secondly this paper investigates a historical rehabilitated building in the site of Tabriz Art University, as a case study and has tried to compile its green design elements. Finally, this work intends to compare mentioned elements with indicators and factors of building rating systems. Findings of the study revealed that “Materials and Resources”, “indoor environmental quality” and also “Sustainable Sites” ,the most significant indicator of rating systems, had major and important role in the rehabilitation of the building. Beyond this materials’ life cycle was considerable in construction.

  2. Repeated training of accredited social health activists (ASHAs) for improved detection of visceral leishmaniasis cases in Bihar, India.

    Science.gov (United States)

    Das, Vidya Nand Ravi; Pandey, Ravindra Nath; Kumar, Vijay; Pandey, Krishna; Siddiqui, Niyamat Ali; Verma, Rakesh Bihari; Matlashewski, Greg; Das, Pradeep

    2016-02-01

    Accredited Social Health Activists (ASHAs) are incentive-based, female health workers responsible for a village of 1000 population and living in the same community and render valuable services towards maternal and child health care, polio elimination program and other health care-related activities including visceral leishmaniasis (VL). One of the major health concerns is that cases remain in the endemic villages for weeks without treatment causing increased likelihood to treatment failure and disease transmission in the community. To address this problem, we have begun a training program for ASHAs to enhance early detection of potential VL cases and referring them to their local Primary Health Centers (PHCs) for diagnosis and treatment. The result of this training showed increased referral rate to PHCs for diagnosis and treatment. Encouraged with the results from a single training session, we determined in the present study whether repeated training of ASHAs resulted in an a further increase in VL case referral to the local PHCs. After two training sessions, VL referrals by ASHAs increased to 46% as compared to 28% after a single training session in this cohort and a baseline of 7% before training. ASHA training is an effective way to conduct active case detection of VL cases and should be repeated once a year. PMID:27077313

  3. The System Kato: Detecting Cases of Plagiarism for Answer-Set Programs

    CERN Document Server

    Oetsch, Johannes; Schwengerer, Martin; Tompits, Hans; 10.1017/S1471068410000402

    2010-01-01

    Plagiarism detection is a growing need among educational institutions and solutions for different purposes exist. An important field in this direction is detecting cases of source-code plagiarism. In this paper, we present the tool Kato for supporting the detection of this kind of plagiarism in the area of answer-set programming (ASP). Currently, the tool is implemented for DLV programs but it is designed to handle other logic-programming dialects as well. We review the basic features of Kato, introduce its theoretical underpinnings, and discuss an application of Kato for plagiarism detection in the context of courses on logic programming at the Vienna University of Technology.

  4. Evaluation of the beat-to-beat detection accuracy of PulseOn wearable optical heart rate monitor.

    Science.gov (United States)

    Parak, Jakub; Tarniceriu, Adrian; Renevey, Philippe; Bertschi, Mattia; Delgado-Gonzalo, Ricard; Korhonen, Ilkka

    2015-08-01

    Heart rate variability (HRV) provides significant information about the health status of an individual. Optical heart rate monitoring is a comfortable alternative to ECG based heart rate monitoring. However, most available optical heart rate monitoring devices do not supply beat-to-beat detection accuracy required by proper HRV analysis. We evaluate the beat-to-beat detection accuracy of a recent wrist-worn optical heart rate monitoring device, PulseOn (PO). Ten subjects (8 male and 2 female; 35.9±10.3 years old) participated in the study. HRV was recorded with PO and Firstbeat Bodyguard 2 (BG2) device, which was used as an ECG based reference. HRV was recorded during sleep. As compared to BG2, PO detected on average 99.57% of the heartbeats (0.43% of beats missed) and had 0.72% extra beat detection rate, with 5.94 ms mean absolute error (MAE) in beat-to-beat intervals (RRI) as compared to the ECG based RRI BG2. Mean RMSSD difference between PO and BG2 derived HRV was 3.1 ms. Therefore, PO provides an accurate method for long term HRV monitoring during sleep. PMID:26738173

  5. Extragalactic Transients in the Era of Wide-Field Radio Surveys. I. Detection Rates and Light Curve Characteristics

    CERN Document Server

    Metzger, Brian D; Berger, Edo

    2015-01-01

    The impending era of wide-field radio surveys has the potential to revolutionize our understanding of astrophysical transients. Here we evaluate the prospects of a wide range of planned and hypothetical radio surveys using the properties and volumetric rates of known and hypothetical classes of extragalactic synchrotron radio transients (e.g., on- and off-axis gamma-ray bursts [GRB], supernovae, tidal disruption events [TDE], compact object mergers). Utilizing these sources and physically motivated considerations we assess the allowed phase-space of radio luminosity and peak timescale for extragalactic transients. We also include for the first time effects such as redshift evolution of the rates, K-corrections, and non-Euclidean luminosity distance, which affect the detection rates of the most sensitive surveys. The number of detected events is calculated by means of a Monte Carlo method, using the various survey properties (depth, cadence, area) and realistic detection criteria that include a cut on the mini...

  6. Low dose-rate intra-operative brachytherapy for soft tissue sarcomas: 85 cases report

    International Nuclear Information System (INIS)

    MATERIAL AND METHODS: Between May 1986 and January 1994, 85 patients with soft tissue sarcomas underwent intra-operative interstitial implants in conjunction with conservative tumor resections. Brachytherapy was part of the initial treatment in 62 cases, and was realized in 23 cases for recurrent tumor. 70/85 (82%) tumors were located in the limbs, 56/85 (66%) were T2 or T3. 38/85 (45%) were involving or close to neuro-vascular structures. The implant dose was 40 - 65 Gy when brachytherapy was the only treatment 31/85 p), mostly for recurrent sarcomas, and 12 - 25 Gy (mean 20 Gy) when combined with external irradiation ((54(85)) p). RESULTS: Median follow-up is 40 months. - 4 years actuarial survival rate is 70.8% for the whole series, 74.5% for previously untreated patients, 61.8 % for patients treated for recurrent tumors. - 4 years actuarial local control rate is respectively 86.4%, 95; 7% and 68.1%. Of the 8 patients with local relapse, 1 is alive without evolutive disease, 7 have developed pulmonary metastasis. Acute side-effects occurred in 18/85 patients (21 %) requiring surgical repair in 8 cases. Late side-effects were mostly fibrosis (30 p), lymphoedemas (8 p), neuropathies (5 p). As a result, functional impairment was observed in 13/85 (15 %) patients. No amputation was required for side-effects. CONCLUSION: This series emphasizes brachytherapy combined with external irradiation is a safe and efficient treatment technique in the treatment of soft tissue sarcomas. The local control rate appears satisfactory and the side-effects tolerable, with limited functional impairment

  7. Casing Pipe Damage Detection with Optical Fiber Sensors: A Case Study in Oil Well Constructions

    OpenAIRE

    Genda Chen; Jun He; Jianping He; Minghua Huang; Zhi Zhou

    2010-01-01

    Casing pipes in oil well constructions may suddenly buckle inward as their inside and outside hydrostatic pressure difference increases. For the safety of construction workers and the steady development of oil industries, it is critically important to measure the stress state of a casing pipe. This study develops a rugged, real-time monitoring, and warning system that combines the distributed Brillouin Scattering Time Domain Reflectometry (BOTDR) and the discrete fiber Bragg grating (FBG) mea...

  8. Proper price signals: The case for reflecting externalities in utility rates

    International Nuclear Information System (INIS)

    As a general proposition, proper pricing of utility energy products is honored more in the breach than the observance. As a result, and also as a general proposition, energy is underpriced. More of it is consumed and hence more scarce resources are devoted to its production than is wise. Increasingly, external cost are being recognized and accounted for in utilities resource planning. Relatively uncharted is the issue of external costs being reflected in rates to consumers. This paper makes the case for having externalities reflected in utility rates, not by complete internalization which while ideal may be unrealistic and therefore unachievable but by a method that simulates the outcome sought when all social costs are internalized and correct price signals transmitted

  9. Alteration in the erythrocyte sedimentation rate in dengue patients: analysis of 1,398 cases

    OpenAIRE

    Luiz José de Souza; Aldo Franklin Ferreira Reis; Fernanda Carlos Rodrigues de Almeida; Lara Assed de Souza; Marina Abukater; Maurício Assed Estefan Gomes; Olívia Araujo Abicair; Pedro Assed Gonçalves

    2008-01-01

    A study of the erythrocyte sedimentation rate during the first hour (ESR) in dengue patients would help determine how this parameter is affected by this disease, as well as whether it can be used for diagnosis. One thousand, three hundred and ninety-eight cases of dengue attended at the Dengue Treatment Center, Campos dos Goytacazes Rio de Janeiro, Brazil, were included. The ESR values were classified as normal or elevated and compared by gender and clinical form of the disease. Among the 1,3...

  10. Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup

    Institute of Scientific and Technical Information of China (English)

    Peter D Siersema; Amit Rastogi; Anke M Leufkens; Paul A Akerman; Kassem Azzouzi; Richard I Rothstein; Frank P Vleggaar

    2012-01-01

    AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye(R) Retroscope(R) Randomized Clinical Evaluation (TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TER-RACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy (SC)and Third Eye colonoscopy (TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects (51.0%),surveillance after previous polypectomy in 87 (25.2%) and diagnostic workup in 82 (23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate (ADR) with TEC of 23.2% compared to SC.Relative risk (RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92 (P =0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11 (P =0.815) for screening,3.15 (P =0.014) for surveillance,8.64 (P =0.039) for diagnostic and 3.34(P =0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was

  11. Duplicated gall bladder detected on 99m Tc HIDA hepatobiliary scintigraphy: A report of two cases

    International Nuclear Information System (INIS)

    Gall bladder (GB) duplication is a rare condition often found incidentally; most of these detected on screening Ultrasonography (USG) for abdominal colic. Nuclear hepatobiliary scan, popularly known as hepatobiliary iminodiacetic acid (HIDA) scan, with its biliary kinetics, is highly specific for picking up abnormalities related to biliary tract and GB. We report two cases of duplication of GB visualized on HIDA scan. First case highlights the role of HIDA scan in diagnosis of duplicated GB, where USG was equivocal with a number of differentials, whereas in the second case, HIDA helped to rule out obstruction in this case of duplicated GB identified on USG; ruling out biliary cause for the abdominal colic

  12. Polysplenia Syndrome Detected after Chest Symptoms in Two Adult Patients: Case Report and Review of Literature

    International Nuclear Information System (INIS)

    Polisplenia syndrome (PSS) is a rare subtype of heterotaxy syndrome and means ambiguous location of the major thoracic and abdominal organs with vascular anomalies and multiple spleens. We reported on the findings of computed tomography (CT) of PSS in adults, detected incidentally. Two woman underwent a CT examination of the thorax for different thoracic pathologies. There were common abnormalities such as hyparterial bronchi and absence of middle lobe fissure on CTscans suggesting heterotaxy syndrome. Therefore, the abdominal CTs were performed to detect the accompanying abdominal anomalies. Our two cases defined as PSS were diagnosed with multiple spleens in the normal location in the abdomen. The left-dominant liver and short pancreas with agenesis of the pancreatic tail and lateral part of the body were detected on CT scan. In the first case, the vascular abnormalities were as follows: variant entrance of the main portal vein into the liver and atypically located superior mesenteric vein (SMV) joining with the splenic vein to form the portal vein. In the second case, the preduodenal portal vein and hemiazygos continuation with interruption of the hepatic segment of the inferior vena cava (IVC) were the vascular anomalies. The bowels were malrotated in the second case. Although such cases are usually admitted as abdominal emergency, our two cases were detected during examinations for thoracic and cardiac pathologies. The knowledge and awareness of PSS can be helpful to diagnose pathology and plan surgical procedures

  13. Error-rate prediction for programmable circuits: methodology, tools and studied cases

    Science.gov (United States)

    Velazco, Raoul

    2013-05-01

    This work presents an approach to predict the error rates due to Single Event Upsets (SEU) occurring in programmable circuits as a consequence of the impact or energetic particles present in the environment the circuits operate. For a chosen application, the error-rate is predicted by combining the results obtained from radiation ground testing and the results of fault injection campaigns performed off-beam during which huge numbers of SEUs are injected during the execution of the studied application. The goal of this strategy is to obtain accurate results about different applications' error rates, without using particle accelerator facilities, thus significantly reducing the cost of the sensitivity evaluation. As a case study, this methodology was applied a complex processor, the Power PC 7448 executing a program issued from a real space application and a crypto-processor application implemented in an SRAM-based FPGA and accepted to be embedded in the payload of a scientific satellite of NASA. The accuracy of predicted error rates was confirmed by comparing, for the same circuit and application, predictions with measures issued from radiation ground testing performed at the cyclotron Cyclone cyclotron of HIF (Heavy Ion Facility) of Louvain-la-Neuve (Belgium).

  14. The Analysis of Relationship between the Rate of Stock Return and Interest Rate with Nonlinear Methods: The Case of Turkey

    OpenAIRE

    Yusuf Ekrem Akbas

    2013-01-01

    In this study, it was analyzed the structure of stationary of Istanbul Stock Exchange return rate and interest rate series and whether it’s are linear in the period of 1986:01-2012:07. It was used linearity and unit root tests developed by Caner and Hansen (2002). As a result of these tests, it was concluded that the series are non-linear and both of series have two regimes. Besides, it was concluded that both of two regimes have unit root in the series of interest rate and first regime has s...

  15. Factors associated with low cure rate of tuberculosis in remote poor areas of Shaanxi Province, China: a case control study

    Directory of Open Access Journals (Sweden)

    Zhang Hongwei

    2010-03-01

    Full Text Available Abstract Background The directly observed therapy-short course (DOTS strategy was introduced in Shaanxi province, China to improve tuberculosis (TB control by means of improved case detection (target: > = 70% and treatment success rates (target: > = 85% in new smear positive (SS+ TB patients. At a provincial level the targets were both reached in 2005. However in 30 (28% out of 107 counties of Shaanxi province the cure rate was below 85%. This study aimed to investigate patient and treatment characteristics associated with non-cure after tuberculosis (TB treatment in these counties. Methods In this case-control study, new smear positive TB cases in 30 counties with a cure rate Results Of the 659 patients included, 153 (23.2% did not have cure as treatment outcome. Interruption of treatment was most strongly associated with non-cure (OR = 8.7, 95% CI 3.9-18.4. Other independent risk factors were co-morbidity, low education level, lack of appetite as an initial symptom of TB disease, diagnosis of TB outside of the government TB control institutes, missing sputum re-examinations during treatment, and not having a treatment observer. Twenty-six percent of patients did not have a treatment observer. The non-cure rate was better for those with a doctor (odds ratio (OR 0.38, 95% confidence interval (CI 0.17-0.88 as treatment observer than for those with a family member (OR 0.62, 95%CI 0.37-1.03. The main reason for interrupted treatment mentioned by patients was presence of adverse effects during treatment (46.5%. Conclusions Interruption of treatment was most strongly associated with non-cure. Although treatment observation by medical staff is preferred, in order to diminish the proportion of patients who do not have a treatment observer and thereby reduce the proportion of patients who interrupt treatment, we suggest making it possible for family members, after sufficient training, to be treatment observers in remote areas where it is logistically

  16. Casing Pipe Damage Detection with Optical Fiber Sensors: A Case Study in Oil Well Constructions

    Directory of Open Access Journals (Sweden)

    Zhi Zhou

    2010-01-01

    Full Text Available Casing pipes in oil well constructions may suddenly buckle inward as their inside and outside hydrostatic pressure difference increases. For the safety of construction workers and the steady development of oil industries, it is critically important to measure the stress state of a casing pipe. This study develops a rugged, real-time monitoring, and warning system that combines the distributed Brillouin Scattering Time Domain Reflectometry (BOTDR and the discrete fiber Bragg grating (FBG measurement. The BOTDR optical fiber sensors were embedded with no optical fiber splice joints in a fiber-reinforced polymer (FRP rebar and the FBG sensors were wrapped in epoxy resins and glass clothes, both installed during the segmental construction of casing pipes. In situ tests indicate that the proposed sensing system and installation technique can survive the downhole driving process of casing pipes, withstand a harsh service environment, and remain intact with the casing pipes for compatible strain measurements. The relative error of the measured strains between the distributed and discrete sensors is less than 12%. The FBG sensors successfully measured the maximum horizontal principal stress with a relative error of 6.7% in comparison with a cross multipole array acoustic instrument.

  17. Postmortem computed tomography for detecting causes of sudden death in infants and children. Retrospective review of cases

    International Nuclear Information System (INIS)

    The aim of this study was to investigate the usefulness of postmortem computed tomography (PMCT) in detecting causes of sudden death in infants and children. Our subjects were 15 nontraumatically deceased patients (nine boys and six girls, ranging in age from 20 days after birth to 12 years old, mean age 1.6 years), who had been in a state of cardiopulmonary arrest on arrival at our hospital. PMCT was performed within 2 h after certification of death: head (15 cases), chest (11 cases), and abdomen (12 cases). Blood was collected from 11 of the patients at the time of cardiopulmonary resuscitation. An autopsy was conducted on two. PMCT did not show any traumatic changes indicating child abuse. It was difficult to presume the cause of death with PMCT alone, but the cause of death in 14 of 15 cases could be presumed by combining information from their medical history, clinical course before death, PMCT findings, laboratory data, and bacterial culture. The remaining subject was classified as cause unknown. The causes of sudden death in infants and children were detected at a high rate when we comprehensively investigated the PMCT and other examination findings. (author)

  18. Alteration in the erythrocyte sedimentation rate in dengue patients: analysis of 1,398 cases

    Directory of Open Access Journals (Sweden)

    Luiz José de Souza

    2008-12-01

    Full Text Available A study of the erythrocyte sedimentation rate during the first hour (ESR in dengue patients would help determine how this parameter is affected by this disease, as well as whether it can be used for diagnosis. One thousand, three hundred and ninety-eight cases of dengue attended at the Dengue Treatment Center, Campos dos Goytacazes Rio de Janeiro, Brazil, were included. The ESR values were classified as normal or elevated and compared by gender and clinical form of the disease. Among the 1,398 cases ESR was normal in 81.25% (n = 1,136, while in 18.75% (n=262 it was elevated. In 83.92% (n=514 of the male dengue patients ESR was normal, while in 16.08% (n=98 it was elevated. Among female dengue patients, 79.17% (n=622 had normal ESR, and in 20.83% (n=164 ESR was elevated (p=0.05. Among patients with classic dengue, 77.28% (n=961 had normal ESR, while in 22.72% (n=282, it was elevated. Also in 85.81% (n=133 of patients with hemorrhagic dengue, ESR was normal, while in 14.19% (n=22 ESR was elevated (p=0.026. We concluded that ESR was within normal ranges in most dengue cases, independent of gender or clinical presentation. Given the high frequency of normality and the ease of determination of this parameter, ESR data can help in the differential diagnosis of dengue.

  19. The significance of MGMT protein detection in evaluation of osteosarcoma necrosis rate after cisplatin chemotherapy

    OpenAIRE

    Cui, Qiu; Li, Dingfeng; Liu, Cheng; guo, Jun; Liu, Shubin; Liu, Yaosheng; Wang, Xiaohong; Zeng, Yanjun

    2011-01-01

    The aim of this article was to investigate the correlation between expression of O6-methylguanine-DNA methyltransferase (MGMT) in osteosarcoma and the curative effect of alkylating agent (Cis-diaminodichloroplatinum, CDDP). 42 male patients and 34 female patients with a median age of 17 years (9 to 43 years) were eligible for this study. According to histopathological types, there were 3 cases of telangiectatic osteogenic sarcoma, 22 cases of osteoblastic, 11 cases of chondroblastic and 16 ca...

  20. Detecting Well Casing Leaks in Bangladesh Using a Salt Spiking Method

    OpenAIRE

    Stahl, M.O.; Ong, J.B.; Harvey, C. F.; Johnson, C. D.; Badruzzaman, A.B.M.; Tarek, M.H.; van Geen, A.; J. A. Anderson; Lane, J. W.

    2014-01-01

    We apply fluid-replacement logging in arsenic-contaminated regions of Bangladesh using a low-cost, down-well fluid conductivity logging tool to detect leaks in the cased section of wells. The fluid-conductivity tool is designed for the developing world: it is lightweight and easily transportable, operable by one person, and can be built for minimal cost. The fluid-replacement test identifies leaking casing by comparison of fluid conductivity logs collected before and after spiking the wellbor...

  1. A Cholecystocolonic Fistula Detected by MRCP in a Patient with Chronic Cholecystitis: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Seong Su; Park, Soo Youn [Catholic University St. Vincent' s Hospital, Suwon (Korea, Republic of)

    2009-08-15

    A cholecystocolonic fistula is an uncommon late complication of chronic gallstone disease. Although it may cause acute life-threatening complications such as bowel obstruction or massive hemorrhaging, its accurate preoperative diagnosis may be difficult due to minimal or nonspecific symptoms. Cholecystocolonic fistulas have been diagnosed by various methods, including ERCP. However, the diagnosis of a cholecystocolonic fistula using MRCP has not been reported in the literature. In this case report, we describe a case of a cholecystocolonic fistula detected by MRCP.

  2. Microscopic polyangiitis complicated with ileal involvement detected by double-balloon endoscopy: a case report

    OpenAIRE

    Fukushima, Masashi; Inoue, Satoko; Ono, Yuichiro; Tamaki, Yoshitaka; Yoshimura, Hajime; Imai, Yukihiro; Inokuma, Tetsuro

    2013-01-01

    Background Microscopic polyangiitis is characterized by pauci-immune, necrotizing small-vessel vasculitis and an anti-neutrophil cytoplasmic antibody-associated vasculitis. Although gastrointestinal involvement in microscopic polyangiitis is not rare, endoscopic observation of it is extremely rare. To the best of our knowledge, this is the first case report of small intestinal involvement in microscopic polyangiitis detected and followed up by double-balloon endoscopy. Case presentation A 70-...

  3. Parathyroid adenoma detected with 99mTc-tetrofosmin dual-phase scintigraphy: a case report

    OpenAIRE

    Romanidis, Konstantinos; Karathanos, Evangelos; Nagorni, Eleni-Aikaterini; Giatromanolaki, Alexandra; Sibridis, Efthimios; Zissimopoulos, Athanassios; Vogiatzaki, Theodosia; Simopoulos, Constantinos; Pitiakoudis, Michael

    2014-01-01

    Background Tc-sestamibi is the most frequently used radionuclide agent for the detection of parathyroid adenomas in the clinical setting. However, Tc-tetrofosmin is another such agent that may be used for this purpose. This case report presents the significance and practicality of 99mTc-tetrofosmin for the diagnosis of parathyroid adenomas with probable high p-glycoprotein levels. Case presentation A 45-year-old woman was referred to our Nuclear Department with a palpable neck nodule suspicio...

  4. Do Instructional Videos on Sputum Submission Result in Increased Tuberculosis Case Detection? A Randomized Controlled Trial

    OpenAIRE

    Mhalu, Grace; Hella, Jerry; Doulla, Basra; Mhimbira, Francis; Mtutu, Hawa; Hiza, Helen; Sasamalo, Mohamed; Rutaihwa, Liliana; Rieder, Hans L; Seimon, Tamsyn; Mutayoba, Beatrice; Mitchell G Weiss; Fenner, Lukas

    2015-01-01

    OBJECTIVE We examined the effect of an instructional video about the production of diagnostic sputum on case detection of tuberculosis (TB), and evaluated the acceptance of the video. TRIAL DESIGN Randomized controlled trial. METHODS We prepared a culturally adapted instructional video for sputum submission. We analyzed 200 presumptive TB cases coughing for more than two weeks who attended the outpatient department of the governmental Municipal Hospital in Mwananyamala (Dar es Salaam, Ta...

  5. Do Instructional Videos on Sputum Submission Result in Increased Tuberculosis Case Detection? A Randomized Controlled Trial.

    OpenAIRE

    Mhalu, Grace; Hella, Jerry; Doulla, Basra; Mhimbira, Francis; Mtutu, Hawa; Hiza, Helen; Sasamalo, Mohamed; Rutaihwa, Liliana; Rieder, Hans L; Seimon, Tamsyn; Mutayoba, Beatrice; Mitchell G Weiss; Fenner, Lukas

    2015-01-01

    OBJECTIVE We examined the effect of an instructional video about the production of diagnostic sputum on case detection of tuberculosis (TB), and evaluated the acceptance of the video. TRIAL DESIGN Randomized controlled trial. METHODS We prepared a culturally adapted instructional video for sputum submission. We analyzed 200 presumptive TB cases coughing for more than two weeks who attended the outpatient department of the governmental Municipal Hospital in Mwananyamala (Da...

  6. Developing a New Model for Conversion Rate Optimization: A Case Study

    Directory of Open Access Journals (Sweden)

    Pim Soonsawad

    2013-04-01

    Full Text Available This paper will discuss conversion rate optimization in online retail environments. The paper reviews previousliterature on the topic and then examines how one company has created its own model and used the model tosuccessfully to enhance Internet businesses’ conversion rate optimization. The paper will then synthesize all ofthe factors seen in the literature and the case study model into a new model.A variety of academic papers on the factors affecting the decision-making process of online customers from2004 through 2012 were examined and an in-depth face-to-face interview was conducted with the founder ofClixo at a 2012 United States “online marketing” forum, with a follow-up interviews conducted via email. Thepaper discusses the effectiveness of the new model.This paper identifies the variables that influence online customer behavior and discusses the importance each ofthe seven elements; catalyst, persuasion, usability, interactivity, trust, aesthetics, and marketing mix. Theinterrelationship of the elements at each stage of the customer decision-making process is reviewed.The paper illustrates how e-Retailers can apply the elements of the framework in delivering a website experiencelikely to maximize the number of purchases from online visitors, and to reinforce post-purchase confidence.The paper identifies two additional key elements in conversion rate optimization and develops a new model thatincorporates the two new elements. This new hierarchical model presents the elements stage-by-stage to helponline retailers to convert visitors into customers.

  7. INTERNAL RATING – AN ACTIVE INSTRUMENT IN THE MANAGEMENT OF BANKING RISKS. CASE STUDY BCR

    Directory of Open Access Journals (Sweden)

    PhD Gabriela Cornelia Piciu

    2013-06-01

    Full Text Available This paper aims to clarify some aspects regarding the banking activity in general, of crediting, in particular, because it involves a risk by the very elements of anticipation underlying the decision of the banking specialists. For the bank it is very important to know this risk, to make an evaluation as close as possible to reality, and to reject or accept it in full awareness. The contribution of the internal rating in terms of efficiency and stability of a bank is shown via a case study – the Romanian Commercial Bank. The internal rating used by BCR is an active instrument for making credit decisions it provides valuable indicators to the banking analysts that can be used to develop de risk management policies and the prudential measures for the balanced risk dispersion. Given the fact that the credit rating contributes to the objective, professional analysis, the system must be continuously improved and developed by categories of clients and types of risk, so that the included criteria and the resulting conclusions are relevant.

  8. High False-Positive Rate of Cytokeratin-19 in Detecting Circulating Tumor Cells for Nasopharyngeal Carcinoma

    OpenAIRE

    Ruey-Ho Kao; Li-Chih Huang

    2002-01-01

    Background: Nasopharyngeal carcinoma (NPC) harbors a higher metastatic potential thanother head and neck cancers. In order to seek a possible surrogate marker forearly detection of recurrent or metastatic disease, we tested the feasibility ofcytokeratin-19 (CK-19)-nested reverse-transcription polymerase chain reaction(RT-PCR) for detecting circulating tumor cells in NPC patients.Methods: Two tubes of blood were sequentially collected in individual draws from 7NPC patients and 15 healthy perso...

  9. MR imaging fails to detect bone marrow oedema in osteomyelitis: report of two cases

    International Nuclear Information System (INIS)

    Bone marrow oedema is the earliest and most sensitive sign in diagnostic imaging of osteomyelitis. In the two demonstrated cases of acute and chronic osteomyelitis, MRI was not able to detect bone marrow oedema due to accompanying haemosiderosis and sclerosis surrounding a bone abscess. (orig.)

  10. MR imaging fails to detect bone marrow oedema in osteomyelitis: report of two cases

    Energy Technology Data Exchange (ETDEWEB)

    Wingen, M.; Alzen, G.; Guenther, R.W. [Technische Hochschule Aachen (Germany). Dept. of Diagnostic Radiology

    1998-03-01

    Bone marrow oedema is the earliest and most sensitive sign in diagnostic imaging of osteomyelitis. In the two demonstrated cases of acute and chronic osteomyelitis, MRI was not able to detect bone marrow oedema due to accompanying haemosiderosis and sclerosis surrounding a bone abscess. (orig.)

  11. Slip-rate increase at Parkfield in 1993 detected by high-precision EDM and borehole tensor strainmeters

    Science.gov (United States)

    Langbein, J.; Gwyther, R.L.; Hart, R.H.G.; Gladwin, M.T.

    1999-01-01

    On two of the instrument networks at Parkfield, California, the two-color Electronic Distance Meter (EDM) network and Borehole Tensor Strainmeter (BTSM) network, we have detected a rate change starting in 1993 that has persisted at least 5 years. These and other instruments capable of measuring crustal deformation were installed at Parkfield in anticipation of a moderate, M6, earthquake on the San Andreas fault. Many of these instruments have been in operation since the mid 1980s and have established an excellent baseline to judge changes in rate of deformation and the coherence of such changes between instruments. The onset of the observed rate change corresponds in time to two other changes at Parkfield. From late 1992 through late 1994, the Parkfield region had an increase in number of M4 to M5 earthquakes relative to the preceding 6 years. The deformation-rate change also coincides with the end of a 7-year period of sub-normal rainfall. Both the spatial coherence of the rate change and hydrological modeling suggest a tectonic explanation for the rate change. From these observations, we infer that the rate of slip increased over the period 1993-1998.On two of the instrument networks at Parkfield, California, the two-color Electronic Distance Meter (EDM) network and Borehole Tensor Strainmeter (BTSM) network, we have detected a rate change starting in 1993 that has persisted at least 5 years. These and other instruments capable of measuring crustal deformation were installed at Parkfield in anticipation of a moderate, M6, earthquake on the San Andreas fault. Many of these instruments have been in operation since the mid 1980s and have established an excellent baseline to judge changes in rate of deformation and the coherence of such changes between instruments. The onset of the observed rate change corresponds in time to two other changes at Parkfield. From late 1992 through late 1994, the Parkfield region had an increase in number of M4 to M5 earthquakes

  12. Gravitational Waves from Extragalactic Inspiraling Binaries: Selection Effects and Expected Detection Rates

    CERN Document Server

    Nutzman, P; Finn, L S; Hendrickson, C; Belczynski, K; Nutzman, Philip; Kalogera, Vicky; Finn, Lee Samuel; Hendrickson, Cy; Belczynski, Krzysztof

    2004-01-01

    We examine the selection effects that determine how the real population of inspiraling binaries is reflected by those potentially observed with ground-based interferometers like LIGO. We lay the ground-work for the interpretation of future observations in terms of constraints on the real population and, correspondingly, binary star evolution models. We combine galaxy catalog information with current models of the galactic BCO mass distribution to simulate the physical distribution of binaries in the nearby universe. We use Monte Carlo methods to determine the fraction of binaries observable by the LIGO detectors from each galaxy as a function of the BCO chirp mass, examining separately the role of source distance, sky position, time of detection, and binary system chirp mass on detection efficiency and selection effects relevant to the three LIGO detectors. Finally, we discuss the implications of the nearby geography of space on anticipated GW detection and compare our results to previous studies, which have ...

  13. The role of extended prostate biopsy on prostate cancer detection rate: a study performed on the bench

    Directory of Open Access Journals (Sweden)

    Luciano Nesrallah

    2008-10-01

    Full Text Available INTRODUCTION: The aim of this prospective study was to compare the advantage of performing prostate biopsy with a greater number of cores using the classic sextant procedure, with the aim of reducing false negative results. MATERIALS AND METHODS: 100 prostates were acquired from consecutive radical prostatectomies performed by the same surgeon. Fourteen cores were obtained on the bench following surgery using an automatic pistol with an 18-gauge needle. Six of these cores were obtained according to the sextant technique, as described by Hodge et al.; with the addition of a further three lateral cores from each lobe and one from the bilateral transition zone. The whole gland and the fragments were assessed by the same pathologist. An analysis of the frequency of the cancers identified in the cores of the sextant and the extended biopsies was undertaken and the results evaluated comparatively. The chi-square test was used for the comparative analysis of the cancer detection rate, according to the technique used. RESULTS: When 6 cores were removed, the positive cancer rate was 75%, which was increased to 88% when 14 cores were (p < 0.001. The withdrawal of 14 cores resulted in a significant 13% (95% CI [5%-21%] increase in the positive rate of cancer detection. CONCLUSION: Extended biopsy, with the removal of 14 cores, is more efficient than the sextant procedure in improving the rate of prostate cancer detection.

  14. The Probability Distribution of the Double Neutron Star Coalescence Rate and Predictions for More Detections

    OpenAIRE

    Kalogera, Vassiliki; Kim, Chunglee; Lorimer, Duncan R.

    2002-01-01

    We present an analysis method that allows us to estimate the Galactic formation of radio pulsar populations based on their observed properties and our understanding of survey selection effects. More importantly, this method allows us to assign a statistical significance to such rate estimates and calculate the allowed ranges of values at various confidence levels. Here, we apply the method to the question of the double neutron star (NS-NS) coalescence rate using the current observed sample, a...

  15. 49 CFR 1109.4 - Mandatory mediation in rate cases to be considered under the stand-alone cost methodology.

    Science.gov (United States)

    2010-10-01

    ... complaint under 49 CFR Part 1111. (b) Within 10 business days after the shipper files its formal complaint... cases, set forth at 49 CFR 1111.8(a). ... 49 Transportation 8 2010-10-01 2010-10-01 false Mandatory mediation in rate cases to be...

  16. Supernova relic neutrinos and the supernova rate problem: Analysis of uncertainties and detectability of ONeMg and failed supernovae

    Energy Technology Data Exchange (ETDEWEB)

    Mathews, Grant J. [Center for Astrophysics, Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Hidaka, Jun; Kajino, Toshitaka; Suzuki, Jyutaro [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan)

    2014-08-01

    Direct measurements of the core collapse supernova rate (R{sub SN}) in the redshift range 0 ≤ z ≤ 1 appear to be about a factor of two smaller than the rate inferred from the measured cosmic massive star formation rate (SFR). This discrepancy would imply that about one-half of the massive stars that have been born in the local observed comoving volume did not explode as luminous supernovae. In this work, we explore the possibility that one could clarify the source of this 'supernova rate problem' by detecting the energy spectrum of supernova relic neutrinos with a next generation 10{sup 6} ton water Čerenkov detector like Hyper-Kamiokande. First, we re-examine the supernova rate problem. We make a conservative alternative compilation of the measured SFR data over the redshift range 0 ≤z ≤ 7. We show that by only including published SFR data for which the dust obscuration has been directly determined, the ratio of the observed massive SFR to the observed supernova rate R{sub SN} has large uncertainties ∼1.8{sub −0.6}{sup +1.6} and is statistically consistent with no supernova rate problem. If we further consider that a significant fraction of massive stars will end their lives as faint ONeMg SNe or as failed SNe leading to a black hole remnant, then the ratio reduces to ∼1.1{sub −0.4}{sup +1.0} and the rate problem is essentially solved. We next examine the prospects for detecting this solution to the supernova rate problem. We first study the sources of uncertainty involved in the theoretical estimates of the neutrino detection rate and analyze whether the spectrum of relic neutrinos can be used to independently identify the existence of a supernova rate problem and its source. We consider an ensemble of published and unpublished core collapse supernova simulation models to estimate the uncertainties in the anticipated neutrino luminosities and temperatures. We illustrate how the spectrum of detector events might be used to establish the

  17. The First Case Report in Italy of Di George Syndrome Detected by Noninvasive Prenatal Testing

    Directory of Open Access Journals (Sweden)

    Giuseppina Rapacchia

    2015-01-01

    Full Text Available Panorama Plus (Natera, a single-nucleotide polymorphism- (SNP- based approach that relies on the identification of maternal and fetal allele distributions, allows the detection of common aneuploidies and also incorporates a panel of 5 microdeletions including Di George syndrome. We report here the first case of Di George syndrome detected by NIPT in Italy; blood was drawn at 12 weeks’ gestation. The patient had an amniocentesis to confirm the diagnosis by MLPA (multiplex ligation-dependent probe amplification and an ultrasound aimed to detect the features associated with the syndrome. A right aortic arch and suspect of thymus atrophy were detected, but not other severe malformations typical of the disease. The patient terminated the pregnancy at 17 weeks. NIPT allowed an early screening of Di George syndrome. As the patient was at low risk, it is likely that an ultrasound would have missed the condition.

  18. Constant false alarm rate algorithm for the dim-small target detection based on the distribution characteristics of target coordinates

    Science.gov (United States)

    Fei, Xiao-Liang; Ren, Kan; Qian, Wei-xian; Wang, Peng-cheng

    2015-10-01

    CFAR (Constant False Alarm Rate) is a key technology in Infrared dim-small target detection system. Because the traditional constant false alarm rate detection algorithm gets the probability density distribution which is based on the pixel information of each area in the whole image and calculates the target segmentation threshold of each area by formula of Constant false alarm rate, the problems including the difficulty of probability distribution statistics and large amount of algorithm calculation and long delay time are existing. In order to solve the above problems effectively, a formula of Constant false alarm rate based on target coordinates distribution is presented. Firstly, this paper proposes a new formula of Constant false alarm rate by improving the traditional formula of Constant false alarm rate based on the single grayscale distribution which objective statistical distribution features are introduced. So the control of false alarm according to the target distribution information is implemented more accurately and the problem of high false alarm that is caused of the complex background in local area as the cloud reflection and the ground clutter interference is solved. At the same time, in order to reduce the amount of algorithm calculation and improve the real-time characteristics of algorithm, this paper divides the constant false-alarm statistical area through two-dimensional probability density distribution of target number adaptively which is different from the general identifying methods of constant false-alarm statistical area. Finally, the target segmentation threshold of next frame is calculated by iteration based on the function of target distribution probability density in image sequence which can achieve the purpose of controlling the false alarm until the false alarm is down to the upper limit. The experiment results show that the proposed method can significantly improve the operation time and meet the real-time requirements on

  19. Effect of adding screening ultrasonography to screening mammography on patient recall and cancer detection rates: A retrospective study in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Tohno, Eriko, E-mail: tohno@tmch.or.jp [Total Health Evaluation Center Tsukuba, 1-2, Amakubo, Tsukuba, Ibaraki 305-0005 (Japan); Umemoto, Takeshi, E-mail: umemoto@tmch.or.jp [Tsukuba Medical Center Hospital, 1-3-1, Amakubo, Tsukuba, Ibaraki 305-0005 (Japan); Sasaki, Kyoko, E-mail: kdon@za.cyberhome.ne.jp [Tsukuba Medical Center Hospital, 1-3-1, Amakubo, Tsukuba, Ibaraki 305-0005 (Japan); Morishima, Isamu, E-mail: morishima@tmch.or.jp [Tsukuba Medical Center Hospital, 1-3-1, Amakubo, Tsukuba, Ibaraki 305-0005 (Japan); Ueno, Ei, E-mail: e-ueno@tmch.or.jp [Tsukuba Medical Center Hospital, 1-3-1, Amakubo, Tsukuba, Ibaraki 305-0005 (Japan)

    2013-08-15

    Purpose: To determine whether adding screening ultrasonography to screening mammography can reduce patient recall rates and increase cancer detection rates. Materials and methods: We analyzed the results of mammography and ultrasonography breast screenings performed at the Total Health Evaluation Center Tsukuba, Japan, between April 2011 and March 2012. We also reviewed the modalities and results of diagnostic examinations from women with mammographic abnormalities who visited the Tsukuba Medical Center Hospital for further testing. Results: Of 11,753 women screened, cancer was diagnosed in 10 (0.22%) of the 4529 participants who underwent mammography alone, 23 (0.37%) of the 6250 participants who underwent ultrasonography alone, and 5 (0.51%) of the 974 participants who underwent mammography and ultrasonography. The recall rate due to mammographic abnormalities was 4.9% for women screened only with mammography and 2.6% for those screened with both modalities. The cancer detection rate was 0.22% for women screened only with mammography (positive predictive value, 4.5%) and 0.31% for those screened with both modalities (positive predictive value, 12.0%). Of the 211 lesions presenting as mammographic abnormalities investigated further, diagnostic ultrasonography found no abnormalities in 63 (29.9%) and benign findings in 69 (33.7%). The rest 36.4% needed mammography, cytological or histological examinations or follow-up in addition to diagnostic ultrasonography. Conclusions: It is possible to reduce the recall rate in screening mammography by combining mammography and ultrasonography for breast screening.

  20. Effect of adding screening ultrasonography to screening mammography on patient recall and cancer detection rates: A retrospective study in Japan

    International Nuclear Information System (INIS)

    Purpose: To determine whether adding screening ultrasonography to screening mammography can reduce patient recall rates and increase cancer detection rates. Materials and methods: We analyzed the results of mammography and ultrasonography breast screenings performed at the Total Health Evaluation Center Tsukuba, Japan, between April 2011 and March 2012. We also reviewed the modalities and results of diagnostic examinations from women with mammographic abnormalities who visited the Tsukuba Medical Center Hospital for further testing. Results: Of 11,753 women screened, cancer was diagnosed in 10 (0.22%) of the 4529 participants who underwent mammography alone, 23 (0.37%) of the 6250 participants who underwent ultrasonography alone, and 5 (0.51%) of the 974 participants who underwent mammography and ultrasonography. The recall rate due to mammographic abnormalities was 4.9% for women screened only with mammography and 2.6% for those screened with both modalities. The cancer detection rate was 0.22% for women screened only with mammography (positive predictive value, 4.5%) and 0.31% for those screened with both modalities (positive predictive value, 12.0%). Of the 211 lesions presenting as mammographic abnormalities investigated further, diagnostic ultrasonography found no abnormalities in 63 (29.9%) and benign findings in 69 (33.7%). The rest 36.4% needed mammography, cytological or histological examinations or follow-up in addition to diagnostic ultrasonography. Conclusions: It is possible to reduce the recall rate in screening mammography by combining mammography and ultrasonography for breast screening

  1. Tracking a Screen and Detecting Its Rate of Change in 3-D Video Scenes of Multipurpose Halls

    Institute of Scientific and Technical Information of China (English)

    N.Charara; I.Jarkass; M.Sokhn; O.AbouKhaled; E.Mugellini

    2014-01-01

    An automatic approach is presented to track a wide screen in a multipurpose hall video scene. Once the screen is located, this system also generates the temporal rate of change by using the edge detection based method. Our approach adopts a scene segmentation algorithm that explores visual features (texture) and depth information to perform efficient screen localization. The cropped region which refers to the wide screen undergoes salient visual cues extraction to retrieve the emphasized changes required in rate-of-change computation. In addition to video document indexing and retrieval, this work can improve the machine vision capability in the behavior analysis and pattern recognition.

  2. A study on cycle slip detection and correction in case of ionospheric scintillation

    Science.gov (United States)

    Ji, Shengyue; Chen, Wu; Weng, Duojie; Wang, Zhenjie; Ding, Xiaoli

    2013-03-01

    This research is aiming for cycle slip detection and correction in case of ionospheric scintillation. Different from the normally discussed situation without ionospheric scintillation, ionospheric delay cannot be neglected due to abrupt ionosphere change. In this case, ionosphere-free testing quantities for cycle slip detection and correction have to be used.In the past research, several geometry-free and ionosphere-free testing quantities have been proposed and in every of them, code measurements are involved. So these geometry-free and ionosphere-free testing quantities are sensitive to code observation noise and multipath.In this research, non-geometry-free and ionosphere-free testing quantities are proposed. Different from previously proposed, the code measurements are not longer involved.Detailed discussion on cycle slip detection and correction in case of ionospheric scintillation are given and method using the new proposed non-geometry-free testing quantities in combination with one previously proposed geometry-free & ionosphere-free wide-lane testing quantity is described.The cycle slip detection and correction performance may not be very reliable with the new proposed method. But it is expected that this research will benefit for future work in this aspect.

  3. Plagiarism by Adult Learners Online: A case study in detection and remediation

    Directory of Open Access Journals (Sweden)

    Christine Jocoy

    2006-06-01

    Full Text Available Detecting and combating plagiarism from Web-based sources is a concern for administrators and instructors involved in online distance education. In this paper, we quantify copy-and-paste plagiarism among adult learners in an online geography course offered through Penn State’s World Campus Geographic Information Systems (GIS certificate program. We also evaluate the effectiveness of an “expectation management” strategy intended to discourage adult learners from unintentional violations. We found that while manual methods detected plagiarism in only about 3 percent of assignments, Turnitin.com revealed a 13 percent plagiarism rate among the same assignments. Our attempts to increase awareness and manage expectations decreased infractions measurably, but not significantly. In contrast, Turnitin.com substantially improved our ability to detect infractions. We conclude that raising awareness and managing expectations about plagiarism may be worthwhile, but is no substitute for systematic detection and vigilant enforcement, even among adult learners.

  4. The usability of green building rating systems in hot arid climates: A case study in Siwa, Egypt

    OpenAIRE

    Attia, Shady; Dabaieh, Marwa

    2013-01-01

    In the last ten years there has been a proliferation of regional building rating systems across the Middle East (ME). Most those emerging rating systems and labels emulate the British and American rating systems BREEAM and LEED that emerged in industrial countries context with an impact reduction paradigm. Thus they are neglecting the local historic, climatic, economic, technological, cultural and social context of the ME. This paper presents a case study of a recently constructed eco-lodge,...

  5. Amniotic fluid 'sludge' detected in patients with subchorionic hematoma: a report of two cases.

    Science.gov (United States)

    Tskitishvili, E; Tomimatsu, T; Kanagawa, T; Sawada, K; Kinugasa, Y; Mimura, K; Kimura, T

    2009-04-01

    Amniotic fluid 'sludge' is defined as the presence of dense aggregates of particulate matter in close proximity to the internal cervical os. It is of clinical significance in asymptomatic patients at high risk for spontaneous delivery, and in patients with preterm labor and intact membranes. Subchorionic hematoma is another ultrasound finding that is associated with a higher incidence of threatened miscarriage and preterm delivery. We report two cases of occurrence of amniotic fluid sludge in patients with previously detected large subchorionic hematoma. In the first case subchorionic hematoma and amniotic fluid sludge were detected by ultrasonography at 13 + 1 and 18 + 6 weeks' gestation, respectively, followed by preterm premature rupture of membranes, placental abruption and emergency Cesarean section. In the second case subchorionic hematoma and amniotic fluid sludge were detected by ultrasound at 11 + 3 and 15 + 5 weeks' gestation, respectively, followed by miscarriage with histological chorioamnionitis. The coincidence of subchorionic hematoma and amniotic fluid sludge in these cases points to a possible connection between these two significant ultrasound findings. PMID:19308930

  6. Low-Complexity Variable Frame Rate Analysis for Speech Recognition and Voice Activity Detection

    DEFF Research Database (Denmark)

    Tan, Zheng-Hua; Lindberg, Børge

    2010-01-01

    present a low-complexity and effective frame selection approach based on a posteriori signal-to-noise ratio (SNR) weighted energy distance: The use of an energy distance, instead of e.g. a standard cepstral distance, makes the approach computationally efficient and enables fine granularity search......, and the use of a posteriori SNR weighting emphasizes the reliable regions in noisy speech signals. It is experimentally found that the approach is able to assign a higher frame rate to fast changing events such as consonants, a lower frame rate to steady regions like vowels and no frames to silence, even...... for very low SNR signals. The resulting variable frame rate analysis method is applied to three speech processing tasks that are essential to natural interaction with intelligent environments. First, it is used for improving speech recognition performance in noisy environments. Secondly, the method is used...

  7. Outbreak detection algorithms for seasonal disease data: a case study using ross river virus disease

    Directory of Open Access Journals (Sweden)

    Gatton Michelle L

    2010-11-01

    Full Text Available Abstract Background Detection of outbreaks is an important part of disease surveillance. Although many algorithms have been designed for detecting outbreaks, few have been specifically assessed against diseases that have distinct seasonal incidence patterns, such as those caused by vector-borne pathogens. Methods We applied five previously reported outbreak detection algorithms to Ross River virus (RRV disease data (1991-2007 for the four local government areas (LGAs of Brisbane, Emerald, Redland and Townsville in Queensland, Australia. The methods used were the Early Aberration Reporting System (EARS C1, C2 and C3 methods, negative binomial cusum (NBC, historical limits method (HLM, Poisson outbreak detection (POD method and the purely temporal SaTScan analysis. Seasonally-adjusted variants of the NBC and SaTScan methods were developed. Some of the algorithms were applied using a range of parameter values, resulting in 17 variants of the five algorithms. Results The 9,188 RRV disease notifications that occurred in the four selected regions over the study period showed marked seasonality, which adversely affected the performance of some of the outbreak detection algorithms. Most of the methods examined were able to detect the same major events. The exception was the seasonally-adjusted NBC methods that detected an excess of short signals. The NBC, POD and temporal SaTScan algorithms were the only methods that consistently had high true positive rates and low false positive and false negative rates across the four study areas. The timeliness of outbreak signals generated by each method was also compared but there was no consistency across outbreaks and LGAs. Conclusions This study has highlighted several issues associated with applying outbreak detection algorithms to seasonal disease data. In lieu of a true gold standard, a quantitative comparison is difficult and caution should be taken when interpreting the true positives, false positives

  8. Y-STR analysis of digital and/or penile penetration cases with no detected spermatozoa.

    Science.gov (United States)

    McDonald, Andrew; Jones, Emma; Lewis, Jennie; O'Rourke, Paula

    2015-03-01

    This forensic casework trial involved Yfiler(®) testing samples from 47 digital and/or penile penetration cases where the medical examination had occurred within 48h of the alleged incident and no spermatozoa had been detected following Sperm Elution(©). 30% of these cases yielded at least one Y-STR profile comprising three or more alleles per profile and 21% yielded at least one Y-STR profile of ten or more alleles per profile. This trial further investigated the persistence of male DNA in different case types, the location of samples submitted for testing and whether samples from different locations benefit from being combined prior to testing. The data supports the use of Y-STR profiling to provide scientific evidence to investigate whether the alleged sexual activity had occurred as well as to obtain probative evidence in spermatozoa negative penetration cases. PMID:25458926

  9. Automatic optimisation of gamma dose rate sensor networks: The DETECT Optimisation Tool

    DEFF Research Database (Denmark)

    Helle, K.B.; Müller, T.O.; Astrup, Poul;

    2014-01-01

    chosen using regular grids or according to administrative constraints. Nowadays, however, the choice can be based on more realistic risk assessment, as it is possible to simulate potential radioactive plumes. To support sensor planning, we developed the DETECT Optimisation Tool (DOT) within the scope of...... monitoring network for early detection of radioactive plumes or for the creation of dose maps. The DOT is implemented as a stand-alone easy-to-use JAVA-based application with a graphical user interface and an R backend. Users can run evaluations and optimisations, and display, store and download the results....... The DOT runs on a server and can be accessed via common web browsers; it can also be installed locally. © 2014 Elsevier Ltd. All rights reserved...

  10. Theoretical direct WIMP detection rates for inelastic scattering to excited states

    International Nuclear Information System (INIS)

    The recent WMAP and Planck data have confirmed that exotic dark matter together with the vacuum energy (cosmological constant) dominate in the flat Universe. Many extensions of the standard model provide dark matter candidates, in particular Weakly Interacting Massive Particles (WIMPs). Thus the direct dark matter detection is central to particle physics and cosmology. Most of the research on this issue has hitherto focused on the detection of the recoiling nucleus. In this paper we study transitions to the excited states, possible in some nuclei, which have sufficiently low lying excited states. Good examples are the first excited states of 127I and 129Xe. We find appreciable branching ratios for the inelastic scattering mediated by the spin cross sections. So, in principle, the extra signature of the gamma ray following the de-excitation of these states can, in principle, be exploited experimentally

  11. Breast cancer detection rates using four different types of mammography detectors

    International Nuclear Information System (INIS)

    To compare the performance of different types of detectors in breast cancer detection. A mammography image set containing subtle malignant non-calcification lesions, biopsy-proven benign lesions, simulated malignant calcification clusters and normals was acquired using amorphous-selenium (a-Se) detectors. The images were adapted to simulate four types of detectors at the same radiation dose: digital radiography (DR) detectors with a-Se and caesium iodide (CsI) convertors, and computed radiography (CR) detectors with a powder phosphor (PIP) and a needle phosphor (NIP). Seven observers marked suspicious and benign lesions. Analysis was undertaken using jackknife alternative free-response receiver operating characteristics weighted figure of merit (FoM). The cancer detection fraction (CDF) was estimated for a representative image set from screening. No significant differences in the FoMs between the DR detectors were measured. For calcification clusters and non-calcification lesions, both CR detectors' FoMs were significantly lower than for DR detectors. The calcification cluster's FoM for CR NIP was significantly better than for CR PIP. The estimated CDFs with CR PIP and CR NIP detectors were up to 15 % and 22 % lower, respectively, than for DR detectors. Cancer detection is affected by detector type, and the use of CR in mammography should be reconsidered. (orig.)

  12. Breast cancer detection rates using four different types of mammography detectors

    Energy Technology Data Exchange (ETDEWEB)

    Mackenzie, Alistair; Warren, Lucy M.; Dance, David R.; Young, Kenneth C. [Royal Surrey County Hospital, National Coordinating Centre for the Physics in Mammography (NCCPM), Guildford (United Kingdom); University of Surrey, Department of Physics, Guildford (United Kingdom); Wallis, Matthew G. [Cambridge University Hospitals NHS Foundation Trust, Cambridge (United Kingdom); NIHR Cambridge Biomedical Research Centre, Cambridge Breast Unit, Cambridge (United Kingdom); Cooke, Julie [Jarvis Breast Screening and Diagnostic Centre, Guildford (United Kingdom); Given-Wilson, Rosalind M. [St George' s Healthcare NHS Trust, Department of Radiology, London (United Kingdom); Chakraborty, Dev P. [University of Pittsburgh, Department of Radiology, Pittsburgh, PA (United States); Halling-Brown, Mark D. [Royal Surrey County Hospital, Scientific Computing, Department of Medical Physics, Guildford (United Kingdom); Looney, Padraig T. [Royal Surrey County Hospital, National Coordinating Centre for the Physics in Mammography (NCCPM), Guildford (United Kingdom)

    2016-03-15

    To compare the performance of different types of detectors in breast cancer detection. A mammography image set containing subtle malignant non-calcification lesions, biopsy-proven benign lesions, simulated malignant calcification clusters and normals was acquired using amorphous-selenium (a-Se) detectors. The images were adapted to simulate four types of detectors at the same radiation dose: digital radiography (DR) detectors with a-Se and caesium iodide (CsI) convertors, and computed radiography (CR) detectors with a powder phosphor (PIP) and a needle phosphor (NIP). Seven observers marked suspicious and benign lesions. Analysis was undertaken using jackknife alternative free-response receiver operating characteristics weighted figure of merit (FoM). The cancer detection fraction (CDF) was estimated for a representative image set from screening. No significant differences in the FoMs between the DR detectors were measured. For calcification clusters and non-calcification lesions, both CR detectors' FoMs were significantly lower than for DR detectors. The calcification cluster's FoM for CR NIP was significantly better than for CR PIP. The estimated CDFs with CR PIP and CR NIP detectors were up to 15 % and 22 % lower, respectively, than for DR detectors. Cancer detection is affected by detector type, and the use of CR in mammography should be reconsidered. (orig.)

  13. Monetary and exchange rate regimes changes: The cases of Poland, Czech Republic, Slovakia and Republic of Serbia

    Directory of Open Access Journals (Sweden)

    Josifidis Kosta

    2009-01-01

    Full Text Available The paper explores (former transition economies, Poland, Czech Republic, Slovakia and the Republic of Serbia, concerning abandonment of the exchange rate targeting and fixed exchange rate regimes and movement toward explicit/implicit inflation targeting and flexible exchange rate regimes. The paper identifies different subperiods concerning crucial monetary and exchange rate regimes, and tracks the changes of specific monetary transmission channels i.e. exchange rate channel, interest rate channel, indirect and direct influences to the exchange rate, with variance decomposition of VAR/VEC model. The empirical results indicate that Polish monetary strategy toward higher monetary and exchange rate flexibility has been performed smoothly, gradually and planned, compared to the Slovak and, especially, Czech case. The comparison of three former transition economies with the Serbian case indicate strong and persistent exchange rate pass-through, low interest rate pass-through, significant indirect and direct influence to the exchange rate as potential obstacles for successful inflation targeting in the Republic of Serbia.

  14. Occult Invasive Lobular Carcinoma of Breast Detected by Stomach Metastasis: A Case Report

    International Nuclear Information System (INIS)

    Gastric metastasis from primary breast cancer is a rare phenomenon that is more prevalent in the invasive lobular type of breast cancer. We describe a very rare case of occult invasive lobular cancer of the breast detected by the initial presentation of gastric metastasis in a patient without a history of breast cancer. A 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) which showed increased FDG uptake in the stomach, abdominal mesentery and the right breast, and played pivotal roles in the detection of occult primary breast cancer and a diagnosis of gastric metastasis as an ancillary method for obtaining histological results and immunohistochemical stains.

  15. Occult Invasive Lobular Carcinoma of Breast Detected by Stomach Metastasis: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    KIm, So Jung; Jung, Hae Kyoung; Ko, Kyung Hee; Yoon, Jung Hyun [Dept. of Radiology, Bundang CHA general Hospital, CHA University College of Medicine, Seongnam (Korea, Republic of)

    2012-02-15

    Gastric metastasis from primary breast cancer is a rare phenomenon that is more prevalent in the invasive lobular type of breast cancer. We describe a very rare case of occult invasive lobular cancer of the breast detected by the initial presentation of gastric metastasis in a patient without a history of breast cancer. A 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) which showed increased FDG uptake in the stomach, abdominal mesentery and the right breast, and played pivotal roles in the detection of occult primary breast cancer and a diagnosis of gastric metastasis as an ancillary method for obtaining histological results and immunohistochemical stains.

  16. Response and Remission in Adolescent Mania: Signal Detection Analyses of the Young Mania Rating Scale

    Science.gov (United States)

    Patel, Nick C.; Patrick, Danielle M.; Youngstrom, Eric A.; Strakowski, Stephen M.; Delbello, Melissa P.

    2007-01-01

    Objective: The purpose of this study was to determine optimal criteria for defining response and remission in adolescents with acute mania. Method: Data were analyzed from three treatment studies of adolescents with acute mania (N = 99). Trained raters completed the Young Mania Rating Scale (YMRS), and clinicians completed the Clinical Global…

  17. 3D versus 2D Systematic Transrectal Ultrasound-Guided Prostate Biopsy: Higher Cancer Detection Rate in Clinical Practice

    Directory of Open Access Journals (Sweden)

    Alexandre Peltier

    2013-01-01

    Full Text Available Objectives. To compare prostate cancer detection rates of extended 2D versus 3D biopsies and to further assess the clinical impact of this method in day-to-day practice. Methods. We analyzed the data of a cohort of 220 consecutive patients with no prior history of prostate cancer who underwent an initial prostate biopsy in daily practice due to an abnormal PSA and/or DRE using, respectively, the classical 2D and the new 3D systems. All the biopsies were done by a single experienced operator using the same standardized protocol. Results. There was no significant difference in terms of age, total PSA, or prostate volume between the two groups. However, cancer detection rate was significantly higher using the 3D versus the 2D system, 50% versus 34% (P<0.05. There was no statistically significant difference while comparing the 2 groups in term of nonsignificant cancer detection. Conclusion. There is reasonable evidence demonstrating the superiority of the 3D-guided biopsies in detecting prostate cancers that would have been missed using the 2D extended protocol.

  18. Time-dependent first flight leakage rates for the general case of a two-region spherical medium

    International Nuclear Information System (INIS)

    Closed form analytical expressions for the time-dependent first-flight leakage rates for the general case of a two-region spherical medium have been obtained using elementary functions. Two cases were considered both for δ-distribution intime and isotropic source emission. The first case has a spatially uniform distributed source in the outer shell region. This result complements previous time-dependent solutions. The second case has a spatially uniform distributed source in the inner central region. This result has applications to spherical deuterium-tritium inertial confinement fusion targets. (Author)

  19. Improved Theoretical Predictions of Microlensing Rates for the Detection of Primordial Black Hole Dark Matter

    OpenAIRE

    Cieplak, Agnieszka M.; Griest, Kim

    2012-01-01

    Primordial Black Holes (PBHs) remain a Dark Matter (DM) candidate of the Standard Model of Particle Physics. Previously, we proposed a new method of constraining the remaining PBH DM mass range using microlensing of stars monitored by NASA's Kepler mission. We improve this analysis using a more accurate treatment of the population of the Kepler source stars, their variability and limb-darkening. We extend the theoretically detectable PBH DM mass range down to $2\\times10^{-10} M_\\sun$, two ord...

  20. Detection Rate of Prostate Cancer on the Basis of the Vienna Nomogram: A Singapore Study

    OpenAIRE

    Teo, Jin Kiat; Poh, Beow Kiong; Ng, Foo Cheong; Fong, Yan Kit

    2014-01-01

    Purpose The purpose of this study was to determine the efficacy of the Vienna nomogram prostate biopsy model in the detection of prostate cancer in our local population. We also assessed the incidence of complications from using such a template. Materials and Methods From January 2006 to June 2007, 120 men with either elevated prostate-specific antigen (PSA) scores (>4 ng/mL) and/or abnormal digital rectal examination were enrolled prospectively to undergo extraction of 6 to 18 cores for tran...

  1. Discrimination power of long-term heart rate variability measures for Chronic Heart Failure detection

    OpenAIRE

    Melillo, Paolo; Fusco, Roberta; Sansone, Mario; Bracale, Marcello; Pecchia, Leandro

    2011-01-01

    The aim of this study was to investigate the discrimination power of standard long-term Heart Rate Variability (HRV) measures for the diagnosis of Chronic Heart Failure (CHF). We performed a retrospective analysis on 4 public Holter databases, analyzing the data of 72 normal subjects and 44 patients suffering from CHF. To assess the discrimination power of HRV measures, we adopted an exhaustive search of all possible combinations of HRV measures and we developed classifiers based on Classi...

  2. Bayesian approach to change point detection of unemployment rate via MCMC methods

    Czech Academy of Sciences Publication Activity Database

    Reisnerová, Soňa

    Plzeň : University of West Bohemia in Pilsen, 2006 - (Lukáš, L.), s. 447-452 ISBN 978-80-7043-480-2. [Mathematical Methods in Economics 2006. Plzeň (CZ), 13.09.2006-15.09.2006] R&D Projects: GA AV ČR IAA101120604 Institutional research plan: CEZ:AV0Z10750506 Keywords : Change point * unemployment rate * MCMC * poisson model Subject RIV: BB - Applied Statistics, Operational Research

  3. Fitting the Stocking Rate with Pastoral Resources to Manage and Preserve Mediterranean Forestlands: A Case Study

    Directory of Open Access Journals (Sweden)

    Elisa Bianchetto

    2015-06-01

    Full Text Available Pasture practices have affected Mediterranean forest ecosystems for millennia, and they are still quite widespread in mountainous areas. Nevertheless, in the last decades, the stability of forest ecosystems has been jeopardized due to the abandonment of traditional agro-pastoral practices, so that the gradual reduction of open areas due to progressive succession processes has caused a high increase of grazing pressure by livestock and wild ungulates feeding on forest areas. This paper aims at showing a methodological approach for evaluating the effect of applying measures in order to improve the grazing value of grasslands and ecotonal patches and lower the grazing impact on native woodlands. A protected area in Sicily (Italy is considered as a representative case study. The analysis of remotely sensed imagery and several field surveys enabled to identify and map six different land use units subject to grazing, i.e., (1 forests; (2 grasslands (pastures dominated by palatable herbs and grasses; (3 overgrazed grasslands (dominated by poisonous and/or thorny herbs and forbs, not palatable; (4 encroached pastures; (5 roadside firebreaks (dominated by palatable herbs with no shrubs; and (6 wooded/ encroached roadside firebreaks. Several data were collected through sample plots selected within each land use unit, in order to assess their pastoral value. These data have been used to define current and optimal animal stock rates aiming at addressing pasture management planning towards a sustainable use of forestland and shrubland.

  4. Discrimination power of long-term heart rate variability measures for chronic heart failure detection.

    Science.gov (United States)

    Melillo, Paolo; Fusco, Roberta; Sansone, Mario; Bracale, Marcello; Pecchia, Leandro

    2011-01-01

    The aim of this study was to investigate the discrimination power of standard long-term heart rate variability (HRV) measures for the diagnosis of chronic heart failure (CHF). The authors performed a retrospective analysis on four public Holter databases, analyzing the data of 72 normal subjects and 44 patients suffering from CHF. To assess the discrimination power of HRV measures, an exhaustive search of all possible combinations of HRV measures was adopted and classifiers based on Classification and Regression Tree (CART) method was developed, which is a non-parametric statistical technique. It was found that the best combination of features is: Total spectral power of all NN intervals up to 0.4 Hz (TOTPWR), square root of the mean of the sum of the squares of differences between adjacent NN intervals (RMSSD) and standard deviation of the averages of NN intervals in all 5-min segments of a 24-h recording (SDANN). The classifiers based on this combination achieved a specificity rate and a sensitivity rate of 100.00 and 89.74%, respectively. The results are comparable with other similar studies, but the method used is particularly valuable because it provides an easy to understand description of classification procedures, in terms of intelligible "if … then …" rules. Finally, the rules obtained by CART are consistent with previous clinical studies. PMID:21203855

  5. Readout circuitry for continuous high-rate photon detection with arrays of InP Geiger-mode avalanche photodiodes

    Science.gov (United States)

    Frechette, Jonathan; Grossmann, Peter J.; Busacker, David E.; Jordy, George J.; Duerr, Erik K.; McIntosh, K. Alexander; Oakley, Douglas C.; Bailey, Robert J.; Ruff, Albert C.; Brattain, Michael A.; Funk, Joseph E.; MacDonald, Jason G.; Verghese, Simon

    2012-06-01

    An asynchronous readout integrated circuit (ROIC) has been developed for hybridization to a 32x32 array of single-photon sensitive avalanche photodiodes (APDs). The asynchronous ROIC is capable of simultaneous detection and readout of photon times of arrival, with no array blind time. Each pixel in the array is independently operated by a finite state machine that actively quenches an APD upon a photon detection event, and re-biases the device into Geiger mode after a programmable hold-off time. While an individual APD is in hold-off mode, other elements in the array are biased and available to detect photons. This approach enables high pixel refresh frequency (PRF), making the device suitable for applications including optical communications and frequency-agile ladar. A built-in electronic shutter that de-biases the whole array allows the detector to operate in a gated mode or allows for detection to be temporarily disabled. On-chip data reduction reduces the high bandwidth requirements of simultaneous detection and readout. Additional features include programmable single-pixel disable, region of interest processing, and programmable output data rates. State-based on-chip clock gating reduces overall power draw. ROIC operation has been demonstrated with hybridized InP APDs sensitive to 1.06-μm and 1.55-μm wavelength, and fully packaged focal plane arrays (FPAs) have been assembled and characterized.

  6. A case of prenatally detected hepatic cyst communicating with the hepatic duct

    OpenAIRE

    Shinsuke Katsuno; Minoru Horisawa; Hiroyuki Fujisaki; Takashi Arikawa; Katsuhiro Kotake; Tsuyoshi Kurokawa; Toshiaki Nonami

    2014-01-01

    Here, we describe the case of a 9-year-old girl. During the patient's prenatal period, her mother had suffered domestic violence perpetrated by the patient's father. On maternal ultrasonography and magnetic resonance imaging, an intraabdominal cystic lesion was detected in the fetus at around the 30th prenatal week. The patient was delivered normally, and there were no evident anomalies on her body. Computed tomography with drip infusion cholangiography and percutaneous retrograde transhepati...

  7. SPATCLUS: an R Package for Arbitrarily Shaped Multiple Spatial Cluster Detection for Case Event Data

    OpenAIRE

    Demattei, Christophe; Molinari, Nicolas

    2006-01-01

    International audience This paper describes an R package, named SPATCLUS, that implements a method recently proposed for spatial cluster detection of case event data. This method is based on a data transformation. This transformation is achieved by the definition of a trajectory which allows to attribute to each point a selection order and the distance to its nearest neighbour. The nearest point is searched among the points which have not yet been selected in the trajectory. Due to the tra...

  8. Real-time remote detection and measurement for airborne imaging spectroscopy: a case study with methane

    OpenAIRE

    Thompson, D. R.; I. Leifer; Bovensmann, H.; Eastwood, M; M. Fladeland; C. Frankenberg; K. Gerilowski; Green, R. O.; S. Kratwurst; Krings, T; B. Luna; A. K. Thorpe

    2015-01-01

    Localized anthropogenic sources of atmospheric CH4 are highly uncertain and temporally variable. Airborne remote measurement is an effective method to detect and quantify these emissions. In a campaign context, the science yield can be dramatically increased by real-time retrievals that allow operators to coordinate multiple measurements of the most active areas. This can improve science outcomes for both single- and multiple-platform missions. We describe a case study of th...

  9. ADAS on COTS with OpenCL: A Case Study with Lane Detection

    OpenAIRE

    Kai Huang, Biao Hu, Long Chen, Alois Knoll, Zhihua Wang

    2016-01-01

    The concept of autonomous cars is driving a boost for car electronics and the size of automotive semiconductor market is foreseen to double by 2025. How to benefit from this boost is an interesting question. This article presents a case study to test the feasibility of using OpenCL as the programming language and COTS components as the underlying platforms for ADAS development. For representative ADAS applications, a scalable lane detection is developed that can tune the trade-off be...

  10. A test case of the deformation rate analysis (DRA) stress measurement method

    Energy Technology Data Exchange (ETDEWEB)

    Dight, P.; Hsieh, A. [Australian Centre for Geomechanics, Univ. of WA, Crawley (Australia); Johansson, E. [Saanio and Riekkola Oy, Helsinki (Finland); Hudson, J.A. [Rock Engineering Consultants (United Kingdom); Kemppainen, K.

    2012-01-15

    As part of Posiva's site and ONKALO investigations, the in situ rock stress has been measured by a variety of techniques, including hydraulic fracturing, overcoring, and convergence measurements. All these techniques involve direct measurements in a drillhole or at the rock surface. An alternative method is to test drillhole core in a way that enables estimation of the magnitudes and orientations of the in situ rock stress. The Kaiser Effect (KE) and Deformation Rate Analysis (DRA) are two ways to do this. In the work reported here, a 'blind' DRA test was conducted on core obtained from the POSE (Posiva's Olkiluoto Spalling Experiment) niche in the ONKALO. The term 'blind' means that the two first authors of this report, who conducted the tests at the Australian Centre for Geomechanics, did not know the depths below surface at which the cores had been obtained. The results of this DRA Test Case are presented, together with an explanation of the DRA procedure. Also, additional information that would help in such DRA testing and associated analysis is explained. One of the problems in comparing the DRA results with the known Olkiluoto stress field is that the latter is highly variable across the site, as experienced by the previous in situ stress measurements and as predicted by numerical analysis. The variability is mainly caused by the presence of the large brittle deformation zones which perturb the local stress state. However, this variability reduces with depth and the stress field becomes more stable at the {approx} 350 m at which the drillhole cores were obtained. Another compounding difficulty is that the stress quantity, being a second order tensor, requires six independent components for its specification. In other words, comparison of the DRA results and the known stress field requires comparison of six different quantities. In terms of the major principal stress orientation, the DRA results predict an orientation completely

  11. Spatial Pattern Detection of Tuberculosis: A Case Study of Si Sa Ket Province, Thailand

    Directory of Open Access Journals (Sweden)

    Siriwan Hassarangsee

    2015-12-01

    Full Text Available This retrospective population-based study was conducted to analyze spatial patterns of tuberculosis (TB incidence in Si Sa Ket province, Thailand. TB notification data from 2004 to 2008 collected from TB clinics throughout the province was used along with population data to reveal a descriptive epidemiology of TB incidences. Global clustering patterns of the occurrence were assessed by using global spatial autocorrelation techniques. Additionally, local spatial pattern detection was performed by using local spatial autocorrelation and spatial scan statistic methods. The findings indicated clusters of the disease occurred in the study area. More specifically, significantly high-rate clusters were mostly detected in Mueang Si Sa Ket and Khukhan districts, which are located in the northwestern part of the province, while significantly low-rate clusters were persistent in Kantharalak and Benchalak districts, which are located at the southeastern area.

  12. Automatic Defect Detection and Classification Technique from Image: A Special Case Using Ceramic Tiles

    CERN Document Server

    Rahaman, G M Atiqur

    2009-01-01

    Quality control is an important issue in the ceramic tile industry. On the other hand maintaining the rate of production with respect to time is also a major issue in ceramic tile manufacturing. Again, price of ceramic tiles also depends on purity of texture, accuracy of color, shape etc. Considering this criteria, an automated defect detection and classification technique has been proposed in this report that can have ensured the better quality of tiles in manufacturing process as well as production rate. Our proposed method plays an important role in ceramic tiles industries to detect the defects and to control the quality of ceramic tiles. This automated classification method helps us to acquire knowledge about the pattern of defect within a very short period of time and also to decide about the recovery process so that the defected tiles may not be mixed with the fresh tiles.

  13. Use of GeneXpert Mycobacterium tuberculosis/rifampicin for rapid detection of rifampicin resistant Mycobacterium tuberculosis strains of clinically suspected multi-drug resistance tuberculosis cases

    Science.gov (United States)

    Guenaoui, Kheira; Ouardi, Aissa; Zeggai, Soumia; Sellam, Feriel; Bekri, Farid; Cherif Touil, Sakina

    2016-01-01

    Background Multi-drug resistance (MDR) TB is defined as tuberculosis (TB) disease caused by a strain of Mycobacterium tuberculosis (MTB) that was resistant to at least isoniazid and rifampicin (RIF). Emerging Multidrug-Resistant TB is one of the major concerns of health policy and rapid detection of M. tuberculosis and detection of RIF resistance in infected patients are essential for disease management. The aim of this study was to evaluate patterns of RIF resistance in cases of sputum positive pulmonary TB by using GeneXpert MTB/RIF and comparing between phenotypic and genotypic testing of RIF resistance in MTB strains of clinically suspected MDR-TB isolated cases in western Algeria. Methods In this study 50 sputum positive cases of pulmonary TB who were potential MDR suspect were included. Their sputum samples were collected and subjected to sputum smear microscopy, culture and conventional MTB/RIF test followed by GeneXpert MTB/RIF assay. Results Of total 50 cases included in this study, MTB was detected in all patients (100%) by GeneXpert MTB/RIF. However, RIF’s resistance was detected in only 21 cases (42%) by GeneXpert MTB/RIF. All RIF resistant strains detected by GeneXpert MTB/RIF were phenotypically confirmed as MDR strains. 42.85% of cases were retreatment failure cases, retreatment cases smear positive at 4 months were 23.82%. While 19.05% of cases were retreatment cases smear positive at diagnosis, and 14.28% patient had history of contact with MDR-TB. Sensitivity, specificity, positive predictive value and negative predictive value of Xpert MTB/RIF to detect RIF resistance in comparison to conventional phenotypic drug susceptibility technique were found equal to the rates of 100%, 100%, 100% and 100%, respectively. Conclusions GeneXpert MTB/RIF assay is efficient and reliable technique for the rapid diagnostic of TB. It’s simplicity, high sensitivity and specificity for RIF resistance detection make this technique a very attractive tool for

  14. Derivative Threshold Actuation for Single Phase Wormhole Detection With Reduced False Alarm Rate

    Directory of Open Access Journals (Sweden)

    K.Aathi Dharshini

    2014-06-01

    Full Text Available Communication in mobile Ad hoc networks is completed via multi-hop ways. Owing to the distributed specification and restricted resource of nodes, MANET is a lot prone to wormhole attacks i.e. wormhole attacks place severe threats to each Ad hoc routing protocol and a few security enhancements. Thus, so as to discover wormholes, totally different techniques are in use. In all those techniques fixation of threshold is merely by trial & error methodology or by random manner. Conjointly wormhole detection is in twin part by putting the nodes that is higher than the edge in a suspicious set, however predicting the node as a wormhole by using some other algorithms. Our aim in this paper is to deduce the traffic threshold level by derivational approach for identifying wormholes in a very single phase in relay network having dissimilar characteristics.

  15. Detecting a Defective Casing Seal at the Top of a Bedrock Aquifer.

    Science.gov (United States)

    Richard, Sandra K; Chesnaux, Romain; Rouleau, Alain

    2016-03-01

    An improperly sealed casing can produce a direct hydraulic connection between two or more originally isolated aquifers with important consequences regarding groundwater quantity and quality. A recent study by Richard et al. (2014) investigated a monitoring well installed in a fractured rock aquifer with a defective casing seal at the soil-bedrock interface. A hydraulic short circuit was detected that produced some leakage between the rock and the overlying deposits. A falling-head permeability test performed in this well showed that the usual method of data interpretation is not valid in this particular case due to the presence of a piezometric error. This error is the direct result of the preferential flow originating from the hydraulic short circuit and the subsequent re-equilibration of the piezometric levels of both aquifers in the vicinity of the inlet and the outlet of the defective seal. Numerical simulations of groundwater circulation around the well support the observed impact of the hydraulic short circuit on the results of the falling-head permeability test. These observations demonstrate that a properly designed falling-head permeability test may be useful in the detection of defective casing seals. PMID:26212855

  16. An investigation towards real time dose rate monitoring, and fuel rod detection in a First Generation Magnox Storage Pond (FGMSP).

    Science.gov (United States)

    Jackson, Sarah F; Monk, Stephen D; Riaz, Zahid

    2014-12-01

    The First Generation Magnox Storage Pond (FGMSP) is located on the Sellafield Nuclear Site, housing legacy spent Magnox nuclear fuel. Some of which has since corroded, forming a layer of Corroded Magnox Sludge (CMS) creating one of the largest decommissioning challenges the UK has faced. In this work the composition, physical properties and potentially high hazard nature of CMS are discussed, as are the gamma emission spectra of spent Magnox fuel rods typical of the ilk stored. We assess the potential use of a RadLine gamma detector to dose rate map this area and provide fuel rod detection. RadLine consists of a small scintillator, fibre optic cable and photon counter. The probe has the unusual advantage of not being electrically active and therefore fully submersible underwater, with the option to deploy hundreds of metres in length. Our experimental method encompasses general purpose Monte Carlo radiation transport code, MCNP, where we describe the modelling of CMS and pond liquor in comprehensive detail, including their radiological spectrum, chemical composition data, and physical properties. This investigation concludes that the maximum energy deposited within the scintillator crystal due to ambient CMS corresponds to a dose rate of 5.65Gy h(-1), thus above this value positive detection of a fuel rod would be anticipated. It is additionally established that the detectable region is within a 20cm range. PMID:25244071

  17. The glow duration time influence on the ionization rate detected in the diodes filled with noble gases on mbar pressures

    Directory of Open Access Journals (Sweden)

    Stepanović Olivera M.

    2003-01-01

    Full Text Available The results of the glow current duration time (glowing-time influence on the ionization rate detected in the gas filled diodes are presented. The electrical breakdown was detected as the minimal current impulse. After that diode glow from the minimal glowing-time (10-3 s, up to the maximal 103 s which overlap the time of the stationary regime formation in the gas diode tube. The diodes were with volumes of 300 cm3, but with a diode gap volume of about 1 cm3 and filled with helium, neon, argon or krypton, at the pressures of the order of mbar. The ionization rates were detected as the residual ionization after the glowing was interrupted, using the electrical breakdown time delay measuring method. The influence of the gap distance stationary current values and the relaxation period were also investigated. The result shows that the stationary regime in such a gas diode is established after the glowing time of 1-3 s, although the breakdown formative times were smaller then 1 ms.

  18. Case study regarding local revenue collection rate in Romania between 2008-2013

    OpenAIRE

    Paul Vasile Zai

    2015-01-01

    This article is trying to present local revenues collection rate in Romania between 2008-2013. It is treating local revenues collection rate from Romania at national, regional, county and local level. The highest local revenues collection rate was 85, 38% in 2013 and the lowest collection rate was 80, 23% in 2009. The average of the collection rate in urban area was 81, 69% and 81, 68%. NV Region has the best collection rate and S Region the lowest. From all 3228 local authorities Mintiu Gher...

  19. Case study regarding local revenue collection rate in Romania between 2008-2013

    OpenAIRE

    Zai Paul Vasile

    2015-01-01

    This article is trying to present local revenues collection rate in Romania between 2008-2013. It is treating local revenues collection rate from Romania at national, regional, county and local level. The highest local revenues collection rate was 85,38% in 2013 and the lowest collection rate was 80,23% in 2009. The average of the collection rate in urban area was 81,69% and 81,68%. NV Region has the best collection rate and S Region the lowest. From all 3228 local authorities Mintiu Gherlii...

  20. A Case Study Correlating Innovative Gamma Ray Scanning Detection Systems Data to Surface Soil Gamma Spectrometry Results - 13580

    International Nuclear Information System (INIS)

    HydroGeoLogic (HGL), Inc. completed a United States Environmental Protection Agency (USEPA) study to characterize radiological contamination at a site near Canoga Park, California. The characterized area contained 470 acres including the site of a prototype commercial nuclear reactor and other nuclear design, testing, and support operations from the 1950's until 1988 [1]. The site history included radiological releases during operation followed by D and D activities. The characterization was conducted under an accelerated schedule and the results will support the project remediation. The project has a rigorous cleanup to background agenda and does not allow for comparison to risk-based guidelines. To target soil sample locations, multiple lines of evidence were evaluated including a gamma radiation survey, geophysical surveys, historical site assessment, aerial photographs, and former worker interviews. Due to the time since production and decay, the primary gamma emitting radionuclide remaining is cesium-137 (Cs-137). The gamma ray survey covered diverse, rugged terrain using custom designed sodium iodide thallium-activated (NaI(Tl)) scintillation detection systems. The survey goals included attaining 100% ground surface coverage and detecting gamma radiation as sensitively as possible. The effectiveness of innovative gamma ray detection systems was tested by correlating field Cs-137 static count ratios to Cs-137 laboratory gamma spectrometry results. As a case study, the area encompassing the former location of the first nuclear power station in the U. S. was scanned, and second by second global positioning system (GPS)-linked gamma spectral data were evaluated by examining total count rate and nuclide-specific regions of interest. To compensate for Compton scattering from higher energy naturally occurring radionuclides (U-238, Th-232 and their progeny, and K-40), count rate ratios of anthropogenic nuclide-specific regions of interest to the total count rate were

  1. The detection rate of early UV emission from supernovae: A dedicated GALEX/PTF survey and calibrated theoretical estimates

    CERN Document Server

    Ganot, Noam; Ofek, Eran O; Sagiv, Ilan; Waxman, Eli; Lapid, Ofer; Kulkarni, Shrinivas R; Ben-Ami, Sagi; Kasliwal, Mansi M; Chelouche, Doron; Rafter, Stephen; Behar, Ehud; Laor, Ari; Poznanski, Dovi; Nakar, Udi; Maoz, Dan; Trakhtenbrot, Benny; Neill, James D; Barlow, Thomas A; Martin, Christofer D; Gezari, Suvi; Arcavi, Iair; Bloom, Joshua s; Nugent, Peter E; Sullivan, Mark

    2014-01-01

    The radius and surface composition of an exploding massive star, as well as the explosion energy per unit mass, can be measured using early UV observations of core collapse supernovae (SNe). We present the first results from a simultaneous GALEX/PTF search for early UV emission from SNe. Six Type II SNe and one Type II superluminous SN (SLSN-II) are clearly detected in the GALEX NUV data. We compare our detection rate with theoretical estimates based on early, shock-cooling UV light curves calculated from models that fit existing Swift and GALEX observations well, combined with volumetric SN rates. We find that our observations are in good agreement with calculated rates assuming that red supergiants (RSGs) explode with fiducial radii of 500 R_solar, explosion energies of 10^51 erg, and ejecta masses of 10 M_solar. Exploding blue supergiants and Wolf-Rayet stars are poorly constrained. We describe how such observations can be used to derive the progenitor radius, surface composition and explosion energy per u...

  2. Incorporating an Exercise Detection, Grading, and Hormone Dosing Algorithm Into the Artificial Pancreas Using Accelerometry and Heart Rate.

    Science.gov (United States)

    Jacobs, Peter G; Resalat, Navid; El Youssef, Joseph; Reddy, Ravi; Branigan, Deborah; Preiser, Nicholas; Condon, John; Castle, Jessica

    2015-11-01

    In this article, we present several important contributions necessary for enabling an artificial endocrine pancreas (AP) system to better respond to exercise events. First, we show how exercise can be automatically detected using body-worn accelerometer and heart rate sensors. During a 22 hour overnight inpatient study, 13 subjects with type 1 diabetes wearing a Zephyr accelerometer and heart rate monitor underwent 45 minutes of mild aerobic treadmill exercise while controlling their glucose levels using sensor-augmented pump therapy. We used the accelerometer and heart rate as inputs into a validated regression model. Using this model, we were able to detect the exercise event with a sensitivity of 97.2% and a specificity of 99.5%. Second, from this same study, we show how patients' glucose declined during the exercise event and we present results from in silico modeling that demonstrate how including an exercise model in the glucoregulatory model improves the estimation of the drop in glucose during exercise. Last, we present an exercise dosing adjustment algorithm and describe parameter tuning and performance using an in silico glucoregulatory model during an exercise event. PMID:26438720

  3. Development of Gas Micro-Strip Chambers for Radiation Detection and Tracking at High Rates

    CERN Multimedia

    2002-01-01

    % RD28 \\\\ \\\\ Micro-Strip Gas Chambers (GMSC) are a promising high rate, high resolution position detector suited for use in high luminosity hadron collider experiments, as general purpose tracker or to improve the performances of preshower counters, transition radiation and inner muon detectors. Large GMSC arrays have been included in proposed LHC and SSC experimental setups. The operating characteristics of GMSC make their use very attractive also for detectors at tau/beauty/charm factories, as well as for synchrotron radiation facilities and medical applications. At the present state of the art, some problems limiting the usefulness of microstrip chambers are the observed gain changes due to charging up of the support, possible long-term degradation due to ageing, limited sizes imposed by fabrication technologies and unavailability of dedicated high-speed, high-density readout electronics. Limited experience exists of operation of GMSC in real experimental conditions, and little if anything is known about p...

  4. Using the Autism Detection in Early Childhood (ADEC) and Childhood Autism Rating Scales (CARS) to Predict Long Term Outcomes in Children with Autism Spectrum Disorders

    Science.gov (United States)

    Nah, Yong-Hwee; Young, Robyn L.; Brewer, Neil

    2014-01-01

    This study evaluated the predictive validity of the Autism Detection in Early Childhood (ADEC; Young, Autism detection in early childhood: ADEC. Australian Council of Educational Research, Camberwell, VIC 2007) and a well-established screening tool, the Childhood Autism Rating Scale (CARS; Schopler et al. The childhood autism rating scale (CARS).…

  5. Case Study: IBM Watson Analytics Cloud Platform as Analytics-as-a-Service System for Heart Failure Early Detection

    Directory of Open Access Journals (Sweden)

    Gabriele Guidi

    2016-07-01

    Full Text Available In the recent years the progress in technology and the increasing availability of fast connections have produced a migration of functionalities in Information Technologies services, from static servers to distributed technologies. This article describes the main tools available on the market to perform Analytics as a Service (AaaS using a cloud platform. It is also described a use case of IBM Watson Analytics, a cloud system for data analytics, applied to the following research scope: detecting the presence or absence of Heart Failure disease using nothing more than the electrocardiographic signal, in particular through the analysis of Heart Rate Variability. The obtained results are comparable with those coming from the literature, in terms of accuracy and predictive power. Advantages and drawbacks of cloud versus static approaches are discussed in the last sections.

  6. Standoff detection and analysis of dust and particles : the state of the art and case studies

    International Nuclear Information System (INIS)

    Point sensors that use vacuum approaches to collect air samples are not well suited for real-time measurements or monitoring of aerosols or dust in large areas, such as mining environments. This paper demonstrated that developments in LiDAR (light detection and ranging) technologies offer capabilities for simple detection of dust particles as well as in-situ assessment of aerosol composition. LiDAR options also include the localization of remote dust clouds, the measurement of their concentration and constituent analysis. The technique involves probing the dust contaminated zones with a laser beam and measuring the level of backscattered light with a collocated detection system. Information regarding the location or content of a dust cloud can be obtained from either elastic response or inelastic response. This presentation included case studies that demonstrated the many technologies developed at Quebec City-based INO for aerosol detection. The technologies included simple range-finding of remote objects, cloud mapping and more complex spectroscopic technologies based on optical inelastic scattering such as laser-induced fluorescence and Raman scattering for particulate identification. The presentation also described the advantages and limitations of the technologies and their suitability for specific mining industry requirements. LiDAR with remote sensing capabilities for dust detection proved to be useful, reliable and affordable. 10 refs., 19 figs.

  7. Effectiveness and Feasibility of Active and Passive Case Detection in the Visceral Leishmaniasis Elimination Initiative in India, Bangladesh, and Nepal

    OpenAIRE

    Hirve, Siddhivinayak; Singh, Shri Prakash; Kumar, Narendra; Banjara, Megha Raj; Das, Pradeep; Sundar, Shyam; Rijal, Suman; Joshi, Anand,; Kroeger, Axel; Varghese, Beena; Thakur, Chandreshwar Prasad; Huda, M Mamun; Mondal, Dinesh

    2010-01-01

    This study analyzed the effectiveness of active case detection (ACD) for new visceral leishmaniasis (VL) cases. ACD detection was carried out using house to house screening in Bangladesh and India and by neighborhood screening around index cases in Nepal. The percent increase of new VL cases through ACD compared to PCD was 6.7–17.1% in India; 38.8% in Nepal; and 60% in Bangladesh. The screening effort was high in India and Bangladesh (house to house screening) compared to Nepal (index case sc...

  8. Real Shocks and the Equilibrium Real Exchange Rate: In the Case of Wage Rigidity

    OpenAIRE

    Hee-Ho Kim; John Dutton

    1997-01-01

    Using a simple exchange rate model, this paper investigates the role of unemployment in determining the ejfects of different shocks on the real exchange rate. The presence of unenioloyment in an economy is shown to significantly alter the relationship between real variables and the real exchange rate. This implies that the generally believed traditional propositions concerning real shocks and the exchange rate might not be valid anymore in the economy with unemployment and thus, that l ignori...

  9. the term structure of interest rates: a first look at the austrian case

    OpenAIRE

    Jäger, Albert

    1985-01-01

    abstract: first, the basic idea of the expectations theory on the term structure of interest rates is sketched. a brief review of empirical evidence on the expectations theory is presented. the paper then derives and estimates a term structure equation for austrian interest rates. the empirical results for this equation seem not to be at variance with the basic idea of the expectations theory, i. e., representing the long term interest rates as a weighted average of expected short rates. a li...

  10. Purchasing Power Parity and Real Exchange Rates in Case of Developing Countries

    OpenAIRE

    Murat Doganlar; Mehmet Ozmen

    2000-01-01

    Purchasing power parity states that changes in the nominal exchange rates should reflect the inflation differences. This indicates that if nominal exchange rate changes reflect home and foreign inflation differences, then real exchange rate should remain unchanged. Recent time series econometrics techniques can test this proposal. If the real exchange rate series contain a unit root, then the series are told to be nonstationary which means that PPP (Purchasing power parity) does not hold. Aug...

  11. The pandemic influenza A (H1N1 2009 vaccine does not increase the mortality rate of idiopathic interstitial pneumonia: a matched case-control study.

    Directory of Open Access Journals (Sweden)

    Hiroshi Yokomichi

    Full Text Available BACKGROUND: Evidence regarding the mortality rate after administration of the pandemic influenza A (H1N1 2009 vaccine on patients with underlying diseases is currently scarce. We conducted a case-control study in Japan to compare the mortality rates of patients with idiopathic interstitial pneumonia after the vaccines were administered and were not administered. METHODS: Between October 2009 and March 2010, we collected clinical records in Japan and conducted a 1:1 matched case-control study. Patients with idiopathic interstitial pneumonia who died during this period were considered case patients, and those who survived were considered control patients. We determined and compared the proportion of each group that received the pandemic influenza A (H1N1 2009 vaccine and estimated the odds ratio. Finally, we conducted simulations that compensated for the shortcomings of the study associated with adjusted severity of idiopathic interstitial pneumonia. RESULTS: The case and control groups each comprised of 75 patients with idiopathic interstitial pneumonia. The proportion of patients who received the pandemic influenza A (H1N1 2009 vaccine was 30.7% and 38.7% for the case and control groups, respectively. During that winter, the crude conditional odds ratio of mortality was 0.63 (95% confidence interval, 0.25-1.47 and the adjusted conditional odds ratio was 1.18 (95% confidence interval, 0.33-4.49; neither was significant. The simulation study showed more accurate conditional odds ratios of 0.63-0.71. CONCLUSIONS: In our study, we detected no evidence that the influenza A (H1N1 2009 vaccine increased the mortality rate of patients with idiopathic interstitial pneumonia. The results, however, are limited by the small sample size and low statistical power. A larger-scale study is required.

  12. Efficient detection of peripheral pulmonary embolism by ventilation/perfusion SPECT in cases where helical CT was non diagnostic

    International Nuclear Information System (INIS)

    In recent year's Helical CT (HCT) has played a major role in the diagnostics of pulmonary embolism (PE). However it may be non diagnostic in small and peripheral pulmonary embolism. For two years we have been using a new and fast pulmonary ventilation/perfusion SPECT method for precise detection of pulmonary embolism. Purpose: To study the feasibility of the fast SPECT method in detection of small PE at patients with negative HCT. Methods: 43 consecutive patients (17 males, 26 females, age 27 - 91 yr ,mean 64 yr) with clinical suspicion of pulmonary embolism but negative finding in HCT were included. A ventilation / perfusion SPECT was performed. The patient was positioned in the triple head gamma camera (Marconi/Philips Irix, LEHR collimators) and Technegas was inhaled until the count rate increased above 1000 c/s. Ventilation SPECT was acquired in ten minutes and then perfusion SPECT in six minutes after the injection, without moving the patient, of 120 - 150 MBq 99mTc-MAA resulting, at least, four times the ventilation count rate. The acquired data was grouped into 120 128 x 128 projections. It was reconstructed iteratively and filtered using the same parameters in both data sets. Both orthogonal slice sets were displayed simultaneously side by side for evaluation. The extension of affected (mismatch) segments at every patient was counted. The amount of the defect was scores as follows: 0 = no defect, 1 = subsegmental defect, 2= segmental defect. For diagnosis of PE the minimal score number was 2. Results: Pulmonary embolism was stated in 14 of 43 helical CT negative patients (32 %). The score number was 2 in six cases, 3 in four cases and 4 or more in four cases. So, the majority of the patients had relatively small and peripheral PE. Conclusion: Ventilation/perfusion SPECT revealed PE at 32 % of the patients with a negative helical CT finding. Ventilation/perfusion SPECT is a fast (acquired in 16 minutes) and precise method for clinical diagnostics of PE. It

  13. The determinants of state foreclosure rates: investigating the case of Indiana

    OpenAIRE

    Leslie McGranahan

    2007-01-01

    Foreclosure rates are defined as mortgages in the foreclosure process as a percentage of all mortgages. These rates vary fairly dramatically across states. While the average foreclosure rate in the 50 states and the District of Columbia in the second quarter of 2007 was 1.25 percent, these rates ranged from a high of 3.60 percent in Ohio to a low of 0.44 percent in Wyoming. One state that has exhibited high foreclosure rates over the past decade is Indiana. Indiana ranked second highest after...

  14. THE VARIANCE AND TREND OF INTEREST RATECASE OF COMMERCIAL BANKS IN KOSOVO

    Directory of Open Access Journals (Sweden)

    Fidane Spahija

    2015-09-01

    Full Text Available Today’s debate on the interest rate is characterized by three key issues: the interest rate as a phenomenon, the interest rate as a product of factors (dependent variable, and the interest rate as a policy instrument (independent variable. In this article, the variance in interest rates, as the dependent variable, comes in two statistical sizes: the variance and trend. The interest rates include the price of loans and deposits. The analysis of interest rates on deposits and loan is conducted for non-financial corporation and family economy. This study looks into a statistical analysis, to highlight the variance and trends of interest rates for the period 2004-2013, for deposits and loans in commercial banks in Kosovo. The interest rate is observed at various levels. Is it high, medium or low? Does it explain growth trends, keep constant, or reduce? The trend is observed whether commercial banks maintain, reduce, or increase the interest rate in response to the policy that follows the Central Bank of Kosovo. The data obtained will help to determine the impact of interest rate in the service sector, investment, consumption, and unemployment.

  15. Data-Driven Approaches for Computation in Intelligent Biomedical Devices: A Case Study of EEG Monitoring for Chronic Seizure Detection

    Directory of Open Access Journals (Sweden)

    Naveen Verma

    2011-04-01

    Full Text Available Intelligent biomedical devices implies systems that are able to detect specific physiological processes in patients so that particular responses can be generated. This closed-loop capability can have enormous clinical value when we consider the unprecedented modalities that are beginning to emerge for sensing and stimulating patient physiology. Both delivering therapy (e.g., deep-brain stimulation, vagus nerve stimulation, etc. and treating impairments (e.g., neural prosthesis requires computational devices that can make clinically relevant inferences, especially using minimally-intrusive patient signals. The key to such devices is algorithms that are based on data-driven signal modeling as well as hardware structures that are specialized to these. This paper discusses the primary application-domain challenges that must be overcome and analyzes the most promising methods for this that are emerging. We then look at how these methods are being incorporated in ultra-low-energy computational platforms and systems. The case study for this is a seizure-detection SoC that includes instrumentation and computation blocks in support of a system that exploits patient-specific modeling to achieve accurate performance for chronic detection. The SoC samples each EEG channel at a rate of 600 Hz and performs processing to derive signal features on every two second epoch, consuming 9 μJ/epoch/channel. Signal feature extraction reduces the data rate by a factor of over 40×, permitting wireless communication from the patient’s head while reducing the total power on the head by 14×.

  16. Hemoglobin Q-Iran detected in family members from Northern Iran: a case report

    Directory of Open Access Journals (Sweden)

    Khorshidi Mohammad

    2012-02-01

    Full Text Available Abstract Introduction Hemoglobin Q-Iran (α75Asp→His is an important member of the hemoglobin Q family, molecularly characterized by the replacement of aspartic acid by histidine. The first report of hemoglobin Q-Iran and the nomenclature of this hemoglobinopathy dates back to 1970. Iran is known as a country with a high prevalence of α- and β-thalassemia and different types of hemoglobinopathy. Many of these variants are yet to be identified as the practice of molecular laboratory techniques is limited in this part of the world. Applying such molecular methods, we report the first hemoglobin Q-Iran cases in Northern Iran. Case presentation An unusual band was detected in an isoelectric focusing test and cellulose acetate electrophoresis of a sample from a 22-year-old Iranian man from Mazandaran Province. Capillary zone electrophoresis analysis identified this band as hemoglobin Q. A similar band was also detected in his mother's electrophoresis (38 years, Iranian ethnicity. The cases underwent molecular investigation and the presence of a hemoglobin Q-Iran mutation was confirmed by the amplification refractory mutation system polymerase chain reaction method. Direct conventional sequencing revealed a single guanine to cytosine missense mutation (c.226G > C; GAC >CAC at codon 75 in the α-globin gene in both cases. Conclusion The wide spectrum and high frequency of nondeletional α-globin mutations in Mazandaran Province is remarkable and seem to differ considerably from what has been found in Mediterranean populations. This short communication reports the first cases of patients with hemoglobin Q found in that region.

  17. Unexpected second primary malignancies detected by f-18 FDG PET/CT during follow-up for primary malignancy: Two case report

    Energy Technology Data Exchange (ETDEWEB)

    Bang, Ji In; Lee, Eun Seong; Kim, Tae Sung; Kim, Seok Ki [Nuclear Medicine, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)

    2015-03-15

    As the survival rate of cancer patients has increased over the last few decades, the risk of cancer survivors developing second primary malignancies has gained attention. We report two rare cases of second primary hematologic malignancy detected by 18F-fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) during follow-up for primary solid malignancies. Acute lymphoblastic leukemia developed in a breast cancer patient and non-Hodgkin lymphoma in an anal cancer patient. F-18 FDG PET/CT findings led to the diagnosis of unexpected second primary hematologic malignancy in cancer survivors in these two cases.

  18. Analysis of variables affecting unemployment rate and detecting for cluster in West Java, Central Java, and East Java in 2012

    Science.gov (United States)

    Samuel, Putra A.; Widyaningsih, Yekti; Lestari, Dian

    2016-02-01

    The objective of this study is modeling the Unemployment Rate (UR) in West Java, Central Java, and East Java, with rate of disease, infant mortality rate, educational level, population size, proportion of married people, and GDRP as the explanatory variables. Spatial factors are also considered in the modeling since the closer the distance, the higher the correlation. This study uses the secondary data from BPS (Badan Pusat Statistik). The data will be analyzed using Moran I test, to obtain the information about spatial dependence, and using Spatial Autoregressive modeling to obtain the information, which variables are significant affecting UR and how great the influence of the spatial factors. The result is, variables proportion of married people, rate of disease, and population size are related significantly to UR. In all three regions, the Hotspot of unemployed will also be detected districts/cities using Spatial Scan Statistics Method. The results are 22 districts/cities as a regional group with the highest unemployed (Most likely cluster) in the study area; 2 districts/cities as a regional group with the highest unemployed in West Java; 1 district/city as a regional groups with the highest unemployed in Central Java; 15 districts/cities as a regional group with the highest unemployed in East Java.

  19. Prospective assessment of the false positive rate of the Australian snake venom detection kit in healthy human samples.

    Science.gov (United States)

    Nimorakiotakis, Vasilios Bill; Winkel, Kenneth D

    2016-03-01

    The Snake Venom Detection Kit (SVDK; bioCSL Pty Ltd, Australia) distinguishes venom from the five most medically significant snake immunotypes found in Australia. This study assesses the rate of false positives that, by definition, refers to a positive assay finding in a sample from someone who has not been bitten by a venomous snake. Control unbroken skin swabs, simulated bite swabs and urine specimens were collected from 61 healthy adult volunteers [33 males and 28 females] for assessment. In all controls, simulated bite site and urine samples [a total of 183 tests], the positive control well reacted strongly within one minute and no test wells reacted during the ten minute incubation period. However, in two urine tests, the negative control well gave a positive reaction (indicating an uninterpretable test). A 95% confidence interval for the false positive rate, on a per-patient rate, derived from the findings of this study, would extend from 0% to 6% and, on a per-test basis, it would be 0-2%. It appears to be a very low incidence (0-6%) of intrinsic true false positives for the SVDK. The clinical impresssion of a high SVDK false positive rate may be mostly related to operator error. PMID:26690978

  20. Characteristics of cirrhosis undiagnosed during life: a comparative analysis of 73 undiagnosed cases and 149 diagnosed cases of cirrhosis, detected in 4929 consecutive autopsies

    DEFF Research Database (Denmark)

    Graudal, Niels; Leth, Peter Mygind; Mårbjerg, Lone;

    1991-01-01

    In 4929 consecutive autopsies performed during a period of 4 years, 222 cases (4.5%) of cirrhosis were found, of which 149 (3%) were detected while the patients were alive (diagnosed cirrhosis) and 73 (1.5%) were not detected while the patients were living (undiagnosed cirrhosis). Fifty-three of...

  1. Event Detection for Hydrothermal Plumes: A case study at Grotto Vent

    Science.gov (United States)

    Bemis, K. G.; Ozer, S.; Xu, G.; Rona, P. A.; Silver, D.

    2012-12-01

    Evidence is mounting that geologic events such as volcanic eruptions (and intrusions) and earthquakes (near and far) influence the flow rates and temperatures of hydrothermal systems. Connecting such suppositions to observations of hydrothermal output is challenging, but new ongoing time series have the potential to capture such events. This study explores using activity detection, a technique modified from computer vision, to identify pre-defined events within an extended time series recorded by COVIS (Cabled Observatory Vent Imaging Sonar) and applies it to a time series, with gaps, from Sept 2010 to the present; available measurements include plume orientation, plume rise rate, and diffuse flow area at the NEPTUNE Canada Observatory at Grotto Vent, Main Endeavour Field, Juan de Fuca Ridge. Activity detection is the process of finding a pattern (activity) in a data set containing many different types of patterns. Among many approaches proposed to model and detect activities, we have chosen a graph-based technique, Petri Nets, as they do not require training data to model the activity. They use the domain expert's knowledge to build the activity as a combination of feature states and their transitions (actions). Starting from a conceptual model of how hydrothermal plumes respond to daily tides, we have developed a Petri Net based detection algorithm that identifies deviations from the specified response. Initially we assumed that the orientation of the plume would change smoothly and symmetrically in a consistent daily pattern. However, results indicate that the rate of directional changes varies. The present Petri Net detects unusually large and rapid changes in direction or amount of bending; however inspection of Figure 1 suggests that many of the events detected may be artifacts resulting from gaps in the data or from the large temporal spacing. Still, considerable complexity overlies the "normal" tidal response pattern (the data has a dominant frequency of

  2. Detection of Hodgkin Transformation in a Case of Chronic Lymphocytic Leukemia by PET/CT

    Directory of Open Access Journals (Sweden)

    Sabire Yılmaz

    2014-06-01

    Full Text Available Richter’s transformation (RT represents the development of high grade lymphoma, most commonly diffuse large B-cell lymphoma, in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL. CLL/SLL may convert also to Hodgkin’s lymphoma, the so-called Hodgkin’s variant of Richter transformation. Histopathological proof is needed to confirm a definitive diagnosis. Patients with RT generally have a poor prognosis, with prompt recognition optimise clinical management. Whole-body PET scan with 18F-FDG can be used for detection of RT of CLL/SLL. We describe the case of 64-year-old woman with CLL/SLL who developed Hodgkin lymphoma detected with PET/CT.

  3. [Detection of cephalopelvic disproportion using a virtual reality model: a feasibility study of three cases].

    Science.gov (United States)

    Ami, O; Chabrot, P; Jardon, K; Rocas, D; Delmas, V; Boyer, L; Mage, G

    2011-01-01

    Routine daily practice shows that successful vaginal delivery for women with suspected narrow pelvis or large fetus remains possible. We present a computer software for the detection of fetopelvic disproportion based on 3D vectorial reconstructions of the fetal head and maternal pelvis with simulation of head passage through the pelvis for collision detection. Three delivery simulations were generated from MR pelvimetry data in two patients, one with narrow pelvis and the other with macrosomic fetus. Based on the simulation, fetus size in both cases was appropriate for the pelvic size, but delivery simulation for the macrosomic fetus concluded that vaginal delivery was mechanically impossible. Further evaluation of this promising software on a larger patient population is necessary. PMID:21352725

  4. 76 FR 76711 - DCP Raptor Pipeline, LLC; Notice of Motion for Extension of Rate Case Filing Deadline

    Science.gov (United States)

    2011-12-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission DCP Raptor Pipeline, LLC; Notice of Motion for Extension of Rate Case Filing Deadline Take notice that on November 30, 2011, DCP Raptor Pipeline, LLC (Raptor) filed a request for an extension consistent with...

  5. Exchange Rate Exposure and Risk Management: The case of Japanese Exporting Firms

    OpenAIRE

    Takatoshi Ito; Satoshi Koibuchi; Kiyotaka Sato; Junko Shimizu

    2015-01-01

    This paper investigates the relationship between the Japanese firms’ exposure to the exchange rate risk and risk management, such as choice of invoicing currency, and financial and operational hedge. The firm’s exposure to the exchange rate risk is estimated by co-movements of the stock prices and exchange rates, following Dominguez (1998) and others. Data on risk management measures—financial and operational hedging, the choice of invoice currency and the price revision strategy (pass-throug...

  6. Fundamental determinants of the long run real exchange rate: The case of Norway

    OpenAIRE

    Bjørnland, Hilde C.; Hungnes, Håvard

    2003-01-01

    Modelling the Norwegian exchange rate against a basket of currencies, we find a robust long-term link between the real exchange rate and real interest differential that is consistent with purchasing power parity (PPP) and uncovered interest parity (UIP). However, PPP alone is rejected. These findings are confirmed focusing on the Norwegian bilateral exchange rate with Germany and (possibly) Sweden, but rejected against the UK and the US. We argue that rejection of bilateral relationships may ...

  7. Forecasting Exchange Rate Density Using Parametric Models: the Case of Brazil

    Directory of Open Access Journals (Sweden)

    Benjamin Miranda Tabak

    2007-06-01

    Full Text Available This paper employs a recently developed parametric technique to obtain density forecasts for the Brazilian exchange rate, using the exchange rate options market. Empirical results suggest that the option market contains useful information about future exchange rate density. These results suggests that density forecasts using options markets may add value for portfolio and risk management, and may be useful for financial regulators to assess financial stability.

  8. EXCHANGE RATE PASS-THROUGH TO DOMESTIC PRICES: THE CASE OF COLOMBIA

    OpenAIRE

    Peter Rowland

    2004-01-01

    This study uses two different econometric frameworks to study exchange rate passthrough to import, producer and consumer prices in Colombia. Both frameworks are based on vector autoregressive (VAR) models, the first using an unrestricted VAR model, and the second using the Johansen framework of multivariate cointegration. Exchange rate pass-through is shown to be incomplete. Import prices, nevertheless, respond quickly to an exchange rate change, where some 80 percent of such a change is pass...

  9. Purchasing Power Parity and ARIMA Models in Forecasting Exchange Rates: The Case of Turkey

    OpenAIRE

    Hasan Vergil; Filiz Ozkan

    2007-01-01

    This study aims to forecast the exchange rates of Turkey by using the Purchasing Power Parity theory (PPP) and its competitor the ARIMA models and compare their forecasting powers. In doing so, the models are estimated using the monthly real exchange rate data between Turkish Lira and Turkey's five biggest trading partners (The USA, Germany, England, France and Italy) for the period 1980- 2003 and using the monthly real exchange rate data between Turkish Lira and European Union for the period...

  10. Measurement of radiocesium concentration in trees using cumulative gamma radiation dose rate detection systems - A simple presumption for radiocesium concentration in living woods using glass-badge based gamma radiation dose rate detection system

    Energy Technology Data Exchange (ETDEWEB)

    Yoshihara, T.; Hashida, S.N. [Plant Molecular Biology, Laboratory of Environmental Science, Central Research Institute of Electric Power Industry (CRIEPI), 1646 Abiko, Chiba 270-1194 (Japan); Kawachi, N.; Suzui, N.; Yin, Y.G.; Fujimaki, S. [Radiotracer Imaging Gr., Quantum Beam Science Center, Japan Atomic Energy Agency (JAEA), 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan); Nagao, Y.; Yamaguchi, M. [Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA), 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan)

    2014-07-01

    Radiocesium from the severe accident at the Fukushima Dai-ichi Nuclear Power Plant on 11 March 2011 contaminates large areas. After this, a doubt for forest products, especially of mushroom, is indelible at the areas. Pruned woody parts and litters are containing a considerable amount of radiocesium, and generates a problem at incineration and composting. These mean that more attentive survey for each subject is expected; however, the present survey system is highly laborious/expensive and/or non-effective for this purpose. On the other hand, we can see a glass-badge based gamma radiation dose rate detection system. This system always utilized to detect a personal cumulative radiation dose, and thus, it is not suitable to separate a radiation from a specific object. However, if we can separate a radiation from a specific object and relate it with the own radiocesium concentration, it would enable us to presume the specific concentration with just an easy monitoring but without a destruction of the target nature and a complicated process including sampling, pre-treatment, and detection. Here, we present the concept of the measurement and results of the trials. First, we set glass-badges (type FS, Chiyoda Technol Corp., Japan) on a part of bough (approximately 10 cm in diameter) of Japanese flowering cherry trees (Prunus x yedoensis cv. Somei-Yoshino) with four different settings: A, a direct setting without any shield; B, a setting with an aluminum shield between bough and the glass-badge; C, a setting with a lead shield between bough and the glass-badge; D, a setting with a lead shield covering the glass-badge to shut the radiation from the surrounding but from bough. The deduction between the amount of each setting should separate a specific radiation of the bough from unlimited radiation from the surrounding. Even if the hourly dose rate is not enough to count the difference, a moderate cumulative dose would clear the difference. In fact, results demonstrated a

  11. Endoscopy Nurse Participation May Increase the Polyp Detection Rate by Second-Year Fellows during Screening Colonoscopies

    Science.gov (United States)

    Kim, Tae Sun; Lee, Do Young; Yoon, Jang Hyuk; Park, Jung Ho; Kim, Hong Joo; Cho, Yong Kyun; Sohn, Chong Il; Jeon, Woo Kyu; Kim, Byung Ik; Lim, Jae Wan

    2012-01-01

    Background/Aims The aim of this study was to assess the effects of endoscopy nurse participation on polyp detection rate (PDR) and adenoma detection rate (ADR) of second-year fellows during screening colonoscopies. Methods This was a single-center, prospective, randomized study comparing a fellow alone and a fellow plus an endoscopy nurse as an additional observer during afternoon outpatient screening colonoscopies. The primary end points were PDR and ADR. Results One hundred ninety-one colonoscopies performed by a fellow alone and 192 colonoscopies performed by a fellow plus an endoscopy nurse were analyzed. The PDR was significantly higher when the nurse was involved (53.1% vs. 41.3%, p<0.05); however, there was no significant difference in the ADR between the two groups (38.5% vs. 29.8%, p=0.073). There was no difference in the percentage of patients with ≥2 polyps, advanced adenomas, polyp size, polyp location, and polyp shapes between the two groups. There was no difference in the PDR according to the level of experience of the endoscopy nurse. Conclusions Endoscopy nurse participation as an additional observer during screening colonoscopy performed by second-year fellow increases the PDR; however, the level of experience of the nurse was not an important factor. PMID:22844563

  12. Time-resolved in vivo luminescence dosimetry for online error detection in pulsed dose-rate brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, Claus E.; Nielsen, Soeren Kynde; Lindegaard, Jacob Christian; Tanderup, Kari [Radiation Research Division, Risoe National Laboratory for Sustainable Energy, Technical University of Denmark, DK-4000 Roskilde (Denmark); Department of Medical Physics, Aarhus University Hospital, DK-8000 Aarhus C (Denmark); Department of Oncology, Aarhus University Hospital, DK-8000 Aarhus C (Denmark); Department of Medical Physics, Aarhus University Hospital, DK-8000 Aarhus C (Denmark)

    2009-11-15

    Purpose: The purpose of this study is to present and evaluate a dose-verification protocol for pulsed dose-rate (PDR) brachytherapy based on in vivo time-resolved (1 s time resolution) fiber-coupled luminescence dosimetry. Methods: Five cervix cancer patients undergoing PDR brachytherapy (Varian GammaMed Plus with {sup 192}Ir) were monitored. The treatments comprised from 10 to 50 pulses (1 pulse/h) delivered by intracavitary/interstitial applicators (tandem-ring systems and/or needles). For each patient, one or two dosimetry probes were placed directly in or close to the tumor region using stainless steel or titanium needles. Each dosimeter probe consisted of a small aluminum oxide crystal attached to an optical fiber cable (1 mm outer diameter) that could guide radioluminescence (RL) and optically stimulated luminescence (OSL) from the crystal to special readout instrumentation. Positioning uncertainty and hypothetical dose-delivery errors (interchanged guide tubes or applicator movements from {+-}5 to {+-}15 mm) were simulated in software in order to assess the ability of the system to detect errors. Results: For three of the patients, the authors found no significant differences (P>0.01) for comparisons between in vivo measurements and calculated reference values at the level of dose per dwell position, dose per applicator, or total dose per pulse. The standard deviations of the dose per pulse were less than 3%, indicating a stable dose delivery and a highly stable geometry of applicators and dosimeter probes during the treatments. For the two other patients, the authors noted significant deviations for three individual pulses and for one dosimeter probe. These deviations could have been due to applicator movement during the treatment and one incorrectly positioned dosimeter probe, respectively. Computer simulations showed that the likelihood of detecting a pair of interchanged guide tubes increased by a factor of 10 or more for the considered patients when

  13. Unusual Case of Occult Brucella Osteomyelitis in the Skull Detected by Bone Scintigraphy

    International Nuclear Information System (INIS)

    Brucellosis is a worldwide infectious disease of animals that can be transmitted to humans. Osteoarticular involvement is the most common complication of brucellosis. A 47-year-old man, who was a stock breeder, complained of myalgia with fever and chills for 2 weeks. The serology titers and blood cultures for brucellosis were positive. Bone scintigraphy demonstrated a focally increased uptake in the left supra orbital area. Plain radiographs showed an osteolytic lesion, and an MRI revealed signal abnormalities in the corresponding site. We present an unusual case of occult Brucella osteomyelitis in the frontal bone of the skull detected by done scintigraphy.

  14. Evidence-based early clinical detection of emerging diseases in food animals and zoonoses: two cases.

    Science.gov (United States)

    Saegerman, Claude; Humblet, Marie-France; Porter, Sarah Rebecca; Zanella, Gina; Martinelle, Ludovic

    2012-03-01

    If diseases of food-producing animals or zoonoses (re-)emerge, early clinical decision making is of major importance. In this particular condition, it is difficult to apply a classic evidence-based veterinary medicine process, because of a lack of available published data. A method based on the partition of field clinical observations (evidences) could be developed as an interesting alternative approach. The classification and regression tree (CART) analysis was used to improve the early clinical detection in two cases of emerging diseases: bovine spongiform encephalopathy (mad cow disease) and bluetongue due to the serotype 8-virus in cattle. PMID:22374122

  15. Complexity, signal detection, and the application of ergonomics: reflections on a healthcare case study.

    Science.gov (United States)

    Dekker, Sidney

    2012-05-01

    Complexity is a defining characteristic of healthcare, and ergonomic interventions in clinical practice need to take into account aspects vital for the success or failure of new technology. The introduction of new monitoring technology, for example, creates many ripple effects through clinical relationships and agents' cross-adaptations. This paper uses the signal detection paradigm to account for a case in which multiple clinical decision makers, across power hierarchies and gender gaps, manipulate each others' sensitivities to evidence and decision criteria. These are possible to analyze and predict with an applied ergonomics that is sensitive to the social complexities of the workplace, including power, gender, hierarchy and fuzzy system boundaries. PMID:21813110

  16. Stream computing for biomedical signal processing: A QRS complex detection case-study.

    Science.gov (United States)

    Murphy, B M; O'Driscoll, C; Boylan, G B; Lightbody, G; Marnane, W P

    2015-08-01

    Recent developments in "Big Data" have brought significant gains in the ability to process large amounts of data on commodity server hardware. Stream computing is a relatively new paradigm in this area, addressing the need to process data in real time with very low latency. While this approach has been developed for dealing with large scale data from the world of business, security and finance, there is a natural overlap with clinical needs for physiological signal processing. In this work we present a case study of streams processing applied to a typical physiological signal processing problem: QRS detection from ECG data. PMID:26737641

  17. Unusual Case of Occult Brucella Osteomyelitis in the Skull Detected by Bone Scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Myung Hee; Lim, Seok Tae; Jeong, Young Jin; Kim, Dong Wook; Jeong, Hwan Jeong; Lee, Chang Seob [Chonbuk National University Medical School, Jeonju (Korea, Republic of)

    2010-06-15

    Brucellosis is a worldwide infectious disease of animals that can be transmitted to humans. Osteoarticular involvement is the most common complication of brucellosis. A 47-year-old man, who was a stock breeder, complained of myalgia with fever and chills for 2 weeks. The serology titers and blood cultures for brucellosis were positive. Bone scintigraphy demonstrated a focally increased uptake in the left supra orbital area. Plain radiographs showed an osteolytic lesion, and an MRI revealed signal abnormalities in the corresponding site. We present an unusual case of occult Brucella osteomyelitis in the frontal bone of the skull detected by done scintigraphy.

  18. Detection of carbon monoxide poisoning that occurred before a house fire in three cases.

    Science.gov (United States)

    Oshima, Toru; Yonemitsu, Kosei; Sasao, Ako; Ohtani, Maki; Mimasaka, Sohtaro

    2015-09-01

    In our institutes, we perform a quantitative evaluation of volatile hydrocarbons in post-mortem blood in all fatal fire-related cases using headspace gas chromatography mass spectrometry. We previously reported that benzene concentrations in the blood were positively correlated with carbon monoxide-hemoglobin (CO-Hb) concentrations in fire-related deaths. Here, we present 3 cases in which benzene concentrations in the blood were not correlated with CO-Hb concentrations. A high CO-Hb concentration without a hydrocarbon component, such as benzene, indicates that the deceased inhaled carbon monoxide that was not related to the smoke from the fire. Comparing volatile hydrocarbons with CO-Hb concentrations can provide more information about the circumstances surrounding fire-related deaths. We are currently convinced that this is the best method to detect if carbon monoxide poisoning occurred before a house fire started. PMID:26004303

  19. How to Calculate Renyi Entropy from Heart Rate Variability, and Why it Matters for Detecting Cardiac Autonomic Neuropathy

    Directory of Open Access Journals (Sweden)

    David eCornforth

    2014-09-01

    Full Text Available Cardiac Autonomic Neuropathy (CAN is a disease that involves nerve damage leading to an abnormal control of heart rate. An open question is to what extent this condition is detectable from Heart Rate Variability (HRV, which provides information only on successive intervals between heart beats, yet is non-invasive and easy to obtain from a 3-lead ECG recording. A variety of measures may be extracted from HRV, including time domain, frequency domain and more complex non-linear measures. Among the latter, Renyi Entropy has been proposed as a suitable measure that can be used to discriminate CAN from controls. However, all entropy methods require estimation of probabilities, and there are a number of ways in which this estimation can be made. In this work, we calculate Renyi entropy using several variations of the histogram method, and a density method based on sequences of RR intervals. In all, we calculate Renyi entropy using nine methods, and compare their effectiveness in separating the different classes of participants. We find that the histogram method using single RR intervals yields an entropy measure that is either incapable of discriminating CAN from controls, or that it provides little information that could not be gained from the standard deviation of the RR intervals. In contrast, probabilities calculated using a density method, based on sequences of RR intervals, yield an entropy measure that provides good separation between groups of participants, and provides information not available from the standard deviation. The main contribution of this work is that different approaches to calculating probability may affect the success of detecting disease. Our results bring new clarity to the methods used to calculate the Renyi entropy in general, and in particular, to the successful detection of CAN.

  20. Heart rate variability parameters and fetal movement complement fetal behavioral states detection via magnetography to monitor vegetative development

    Directory of Open Access Journals (Sweden)

    Rossitza Draganova

    2015-04-01

    Full Text Available Fetal behavioral states are defined by fetal movement and heart rate variability (HRV. At 32 weeks of gestational age (GA the distinction of four fetal behavioral states represented by combinations of quiet or active sleep or awakeness is possible. Prior to 32 weeks, only periods of fetal activity and quiesence can be distinguished. The increasing synchronization of fetal movement and HRV reflects the development of the autonomic nervous system (ANS control. Fetal magnetocardiography (fMCG detects fetal heart activity at high temporal resolution, enabling the calculation of HRV parameters. This study combined the criteria of fetal movement with the HRV analysis to complete the criteria for fetal state detection. HRV parameters were calculated including the standard deviation of the normal-to-normal R–R interval (SDNN, the mean square of successive differences of the R–R intervals (RMSSD, SDNN/RMSSD ratio, and permutation entropy (PE to gain information about the developing influence of the ANS within each fetal state. In this study, 55 magnetocardiograms from healthy fetuses of 24 – 41 weeks’ GA were recorded for up to 45 minutes using a fetal biomagnetometer. Fetal states were classified based on HRV and movement detection. HRV parameters were calculated for each state. Before GA 32 weeks, 58.4% quiescence and 41.6% activity cycles were observed. Later, 24% quiet sleep state (1F, 65.4% active sleep state (2F, and 10.6% active awake state (4F were observed. SDNN increased over gestation. Changes of HRV parameters between the fetal behavioral states, especially between 1F and 4F, were statistically significant. Increasing fetal activity was confirmed by a decrease in PE complexity measures. The fHRV parameters support the differentiation between states and indicate the development of autonomous nervous control of heart rate function.

  1. A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies.

    Science.gov (United States)

    Balliu, Brunilda; Zaitlen, Noah

    2016-04-01

    Epistasis plays a significant role in the genetic architecture of many complex phenotypes in model organisms. To date, there have been very few interactions replicated in human studies due in part to the multiple-hypothesis burden implicit in genome-wide tests of epistasis. Therefore, it is of paramount importance to develop the most powerful tests possible for detecting interactions. In this work we develop a new SNP-SNP interaction test for use in case-only trio studies called the trio correlation (TC) test. The TC test computes the expected joint distribution of marker pairs in offspring conditional on parental genotypes. This distribution is then incorporated into a standard 1 d.f. correlation test of interaction. We show via extensive simulations under a variety of disease models that our test substantially outperforms existing tests of interaction in case-only trio studies. We also demonstrate a bias in a previous case-only trio interaction test and identify its origin. Finally, we show that a previously proposed permutation scheme in trio studies mitigates the known biases of case-only tests in the presence of population stratification. We conclude that the TC test shows improved power to identify interactions in existing, as well as emerging, trio association studies. The method is publicly available atwww.github.com/BrunildaBalliu/TrioEpi. PMID:26865367

  2. Remnant Pancreatectomy for Recurrent or Metachronous Pancreatic Carcinoma Detected by FDG-PET: Two Case Reports

    Directory of Open Access Journals (Sweden)

    Masaru Koizumi

    2010-01-01

    Full Text Available Context Although surgical resection is the only curative therapeutic option for recurrent or metachronous pancreatic carcinomas, most such cancers are beyond surgical curability. We herein report on two rare cases of remnant pancreatectomy used to treat recurrent or metachronous pancreatic carcinomas. Case reports Case#1 A 65-year-old male developed weight loss and diabetes mellitus 83 months after a pylorus-preserving pancreaticoduodenectomy followed by two years of adjuvant chemotherapy (5- fluorouracil plus leucovorin plus mitomycin C for a pancreatic carcinoma in the head of the pancreas (stage IA. An abdominal CT scan revealed a 3 cm tumor in the remnant pancreas which appeared as a ‘hot’ nodule on FDG-PET. A remnant distal pancreatectomy was performed and a pancreatic carcinoma similar in profile to the primary lesion (stage IIB was confirmed pathologically. Case#2 A 67-year-old male showed increased CA 19-9 levels 25 months after a distal pancreatectomy for a pancreatic carcinoma in the body of the pancreas (stage IA. An abdominal CT scan revealed a cystic lesion in the cut end of the pancreas which appeared as a ‘hot’ nodule on FDG-PET. A remnant proximal pancreatectomy with duodenectomy was performed and a metachronous pancreatic carcinoma (stage III was confirmed pathologically. Conclusion Remnant pancreatectomy can be considered a treatment option for recurrent or metachronous pancreatic carcinomas. FDG-PET can play a key role in detecting remnant pancreatic carcinomas.

  3. AN ANALYSIS OF INTERNATIONAL PRICE AND EXCHANGE RATE ELASTICITY FOR US SOYBEANS: THE CASE OF JAPAN

    OpenAIRE

    Paudel, Laxmi; Kinnucan, Henry W.; Adhikari, Murali; Houston, Jack E.

    2004-01-01

    Stepwise model selection criteria were tested against the restrictive forms to determine the appropriate model and to confirm the law of one price for the US soybeans. Analysis shows less than one international price transmission and exchange rate elasticities in the long run indicate an incomplete exchange rate pass through.

  4. 1. Detection of sodium leakages in sodium circuits. 2. Actions in case of potentially dangerous situations. 3. Actual case histories

    International Nuclear Information System (INIS)

    It is of fundamental importance for sodium circuits to detect leakages as fast as possible. This is necessary both for small and large leakages. In case of large leakages the level of the free sodium surfaces will decrease quickly. Sodium vapour as well as Na2O and NaOH aerosols will cause an alarm of the intallated smoke detectors. With the exception of a leak in an oil-fired sodium heater we never had a large leak due to a rupture of a tube. It seems to us that small leakages, caused by pinholes or a crack are as dangerous for a sodium circuit as large leakage. Small leakages may remain undiscovered for a long time as practice has shown. During that time severe corrosion can occur even in a nitrogen atmosphere which has only a small concentration of oxygen and humidity. Simultaneously an increasing deterioriation by nitriding of the material which is in contact with the sodium vapour will happen probably. As a consequence of nitriding hardness and tensile strength will incease and elongation will be reduced. As observed, a complete rupture of the structural materil in the region of the leak is possible, due to the above-mentioned reasons. We have published some interesting observations we made after dismantling of the KNK steam generator prototype for post-operational metallurgical examinations. The detection of small leakages which may possibly remain unobserved within the thermal insulation during a longer period of time is of high importance with respect to safety of sodium circuits

  5. Detecting Direct Collapse Black Holes: making the case for CR7

    Science.gov (United States)

    Agarwal, Bhaskar; Johnson, Jarrett L.; Zackrisson, Erik; Labbe, Ivo; van den Bosch, Frank C.; Natarajan, Priyamvada; Khochfar, Sadegh

    2016-05-01

    We propose that one of the sources in the recently detected system CR7 by Sobral et al. (2015) through spectro-photometric measurements at z = 6.6 harbors a direct collapse blackhole (DCBH). We argue that the LW radiation field required for direct collapse in source A is provided by sources B and C. By tracing the LW production history and star formation rate over cosmic time for the halo hosting CR7 in a ΛCDM universe, we demonstrate that a DCBH could have formed at z ˜ 20. The spectrum of source A is well fit by nebular emission from primordial gas around a BH with MBH ˜4.4 × 106~M⊙ accreting at a 40% of the Eddington rate, which strongly supports our interpretation of the data. Combining these lines of evidence, we argue that CR7 might well be the first DCBH candidate.

  6. Detecting Direct Collapse Black Holes: making the case for CR7

    CERN Document Server

    Agarwal, Bhaskar; Zackrisson, Erik; Labbe, Ivo; Bosch, Frank C van den; Natarajan, Priyamvada; Khochfar, Sadegh

    2015-01-01

    We propose that one of the sources in the recently detected system CR7 by Sobral et al. (2015) through spectro-photometric measurements at $z = 6.6$ harbors a direct collapse blackhole (DCBH). We argue that the LW radiation field required for direct collapse in source A is provided by sources B and C. By tracing the LW production history and star formation rate over cosmic time for the halo hosting CR7 in a $\\Lambda$CDM universe, we demonstrate that a DCBH could have formed at $z\\sim 20$. The spectrum of source A is well fit by nebular emission from primordial gas around a BH with MBH $\\sim 4.4 \\times 10^6 \\ M_{\\odot}$ accreting at a 40% of the Eddington rate, which strongly supports our interpretation of the data. Combining these lines of evidence, we argue that CR7 might well be the first DCBH candidate.

  7. Detecting direct collapse black holes: making the case for CR7

    Science.gov (United States)

    Agarwal, Bhaskar; Johnson, Jarrett L.; Zackrisson, Erik; Labbe, Ivo; van den Bosch, Frank C.; Natarajan, Priyamvada; Khochfar, Sadegh

    2016-08-01

    We propose that one of the sources in the recently detected system CR7 by Sobral et al. through spectrophotometric measurements at z = 6.6 harbours a direct collapse black hole (DCBH). We argue that the LW radiation field required for direct collapse in source A is provided by sources B and C. By tracing the LW production history and star formation rate over cosmic time for the halo hosting CR7 in a ΛCDM universe, we demonstrate that a DCBH could have formed at z ˜ 20. The spectrum of source A is well fit by nebular emission from primordial gas around a BH with MBH ˜4.4 × 106 M⊙ accreting at a 40 per cent of the Eddington rate, which strongly supports our interpretation of the data. Combining these lines of evidence, we argue that CR7 might well be the first DCBH candidate.

  8. Testing the Relationship between Interest Rates Volatility and Market Capitalization: the case of Mauritius

    Directory of Open Access Journals (Sweden)

    Edesiri Godsday Okoro

    2014-12-01

    Full Text Available This paper tests the relationship between interest rates volatility and market capitalization in Mauritius. Using annual time series data sourced from the Financial Services Commission Annual Statistical Bulletin of Mauritius during the period 2006 through 2010, data of interest rates volatility and market capitalization were estimated in a non-linear model using the Vector Auto-regression technique. The study found that interest rates volatility has significant effect on the level of market capitalization although a negative effect. This implies a negative relationship between interest rates volatility and market capitalization. Thus, if market capitalization is affected by interest rates, then the economy becomes highly susceptible to volatile external distress. This indicates some dangers for the economic survival of Mauritius. It was on this note that we recommended an effective policy aimed at stabilizing macroeconomic variable like interest rates, focusing at the same time on alternative measures of promoting market capitalization if aggregate economic growth must be harnessed. Policymakers should design the optimal policy mix that would help the nation cope efficiently with the economic and social costs of the external distress accompanying higher and dwindling interest rates in Mauritius.

  9. Common factors and the exchange rate: results from the Brazilian case

    Directory of Open Access Journals (Sweden)

    Wilson Rafael de Oliveira Felício

    2014-03-01

    Full Text Available This paper studies the usefulness of factor models in explaining the dynamics of the exchange rate Real / Dollar from January 1999 to August 2011. The paper verifies that the inclusion of factors embedded on the common movements of exchange rates of a set of countries significantly improves the in-sample and out-of-sample predictive power of the models comprising only macroeconomic fundamentals commonly used in the literature to forecast the exchange rate. The paper also links the information contained in the factors to global shocks like the demand for dollars - a "dollar effect", volatility and liquidity of global financial markets.

  10. High utility of contact investigation for latent and active tuberculosis case detection among the contacts: a retrospective cohort study in Tbilisi, Georgia, 2010-2011.

    Directory of Open Access Journals (Sweden)

    Tsira Chakhaia

    Full Text Available The study was conducted at the National Center for Tuberculosis and Lung Diseases (NCTBLD in Tbilisi, Georgia.To assess the utility of contact investigation for tuberculosis (TB case detection. We also assessed the prevalence and risk factors for active TB disease and latent TB infection (LTBI among contacts of active pulmonary TB cases.A retrospective cohort study was conducted among the contacts of active pulmonary TB cases registered in 2010-2011 at the NCTBLD in Tbilisi, Georgia. Contacts of active TB patients were investigated according to an "invitation model": they were referred to the NCTBLD by the index case; were queried about clinical symptoms suggestive of active TB disease; tuberculin skin testing and chest radiographs were performed. Demographic, laboratory, and clinical data of TB patients and their contacts were abstracted from existing records up to February 2013.869 contacts of 396 index cases were enrolled in the study; a median of 2 contacts were referred per index case. Among the 869 contacts, 47 (5.4% were found to have or developed active TB disease: 30 (63.8% were diagnosed with TB during the baseline period (co-prevalent cases and 17 (36.2% developed active TB disease during the follow-up period (mean follow up of 21 months (incident TB cases. The incidence rate of active TB disease among contacts was 1126.0 per 100,000 person years (95% CI 655.7-1802.0 per 100,000 person-years. Among the 402 contacts who had a tuberculin skin test (TST performed, 52.7% (95% CI 47.7-57.7% had LTBI.A high prevalence of LTBI and active TB disease was found among the contacts of TB cases in Tbilisi, Georgia. Our findings demonstrated that an "invitation" model of contact investigation was an effective method of case detection. Therefore, contact investigation should be scaled up in Georgia.

  11. On The Exchange Rate Risk Contribution To The Performance Of International Investments: The Case Of Romania

    Directory of Open Access Journals (Sweden)

    Alexandra HOROBET

    2009-05-01

    Full Text Available The paper examines the impact of changes in the Romanian currency exchange rates against the US dollar and the euro on an investment in the Romanian stock market from the perspective of a US dollar and euro based investor. Our analysis is directed towards identifying the significance of exchange rate volatility for the total risk of a Romanian investment from the perspective of investors with the US dollar and euro as reference currencies. Our results indicate that during more turbulent times investors were better off if invested in their home markets. We also find that the exchange rate risk decreased the risk that a US dollar or a euro-based investor was exposed to in Romania. The contribution of exchange rate risk to the risk of an international investor diversified in his home market and the Romanian market is small, even negative, with no significant differences turbulent versus normal times.

  12. High prevalence of tuberculosis and insufficient case detection in two communities in the Western Cape, South Africa.

    Directory of Open Access Journals (Sweden)

    Mareli Claassens

    Full Text Available BACKGROUND: In South Africa the estimated incidence of all forms of tuberculosis (TB for 2008 was 960/100000. It was reported that all South Africans lived in districts with Directly Observed Therapy, Short-course. However, the 2011 WHO report indicated South Africa as the only country in the world where the TB incidence is still rising. AIMS: To report the results of a TB prevalence survey and to determine the speed of TB case detection in the study communities. METHODS: In 2005 a TB prevalence survey was done to inform the sample size calculation for the ZAMSTAR (Zambia South Africa TB and AIDS Reduction trial. It was a cluster survey with clustering by enumeration area; all households were visited within enumeration areas and informed consent obtained from eligible adults. A questionnaire was completed and a sputum sample collected from each adult. Samples were inoculated on both liquid mycobacterium growth indicator tube (MGIT and Löwenstein-Jensen media. A follow-up HIV prevalence survey was done in 2007. RESULTS: In Community A, the adjusted prevalence of culture positive TB was 32/1000 (95%CI 25-41/1000 and of smear positive TB 8/1000 (95%CI 5-13/1000. In Community B, the adjusted prevalence of culture positive TB was 24/1000 (95%CI 17-32/1000 and of smear positive TB 9/1000 (95%CI 6-15/1000. In Community A the patient diagnostic rate was 0.38/person-year while in community B it was 0.30/person-year. In both communities the adjusted HIV prevalence was 25% (19-30%. DISCUSSION: In both communities a higher TB prevalence than national estimates and a low patient diagnostic rate was calculated, suggesting that cases are not detected at a sufficient rate to interrupt transmission. These findings may contribute to the rising TB incidence in South Africa. The TB epidemic should therefore be addressed rapidly and effectively, especially in the presence of the concurrently high HIV prevalence.

  13. The impact of real oil price on real effective exchange rate: The case of Azerbaijan

    OpenAIRE

    Hasanov, Fakhri

    2010-01-01

    Using quarterly data from 2000-2007 and applying Error Correction Model and Johansen Co- integration Approaches I estimate the impact of real oil price on the real exchange rate of Azerbaijani manat. Estimation outputs derived from these approaches are very close to each other and indicate that real oil price has statistically significant positive impact on real exchange rate in the long-run. Besides, revealed that relative price as a proxy for productivity has also explana...

  14. The exchange rate as an adjustment mechanism: a structural VAR approach to the case of Ireland

    OpenAIRE

    Dermot Hodson

    2003-01-01

    Ireland’s participation in stage three of Economic and Monetary Union precludes exchange rate adjustment in response to asymmetric shocks. A Structural VAR model is used to decompose the effects of asymmetric supply, demand and nominal disturbances on macroeconomic imbalances between Ireland and the UK and on the Irish pound-sterling exchange rate. The results indicate that supply shocks account for a significant degree of the fluctuation in both variables. This lends weight to the view that ...

  15. Central Bank Communication and Interest Rates: The Case of the Czech National Bank

    OpenAIRE

    Horvath, Roman; Karas, Pavel

    2013-01-01

    We examine how written and oral central bank communications affect the level and volatility of interest rates. We use detailed daily data on the Czech central bank’s communication in 2007–2012. We find that financial markets respond to central bank communication. Short-term interest rates rise if the bank communicates that economic conditions are good. The results suggest that written communication, but not oral communication, decreases the volatility of both short-term and long-term interest...

  16. Convergence Rate of Stochastic Gradient Search in the Case of Multiple and Non-Isolated Minima

    OpenAIRE

    Tadić, Vladislav B.

    2009-01-01

    The convergence rate of stochastic gradient search is analyzed in this paper. Using arguments based on differential geometry and Lojasiewicz inequalities, tight bounds on the convergence rate of general stochastic gradient algorithms are derived. As opposed to the existing results, the results presented in this paper allow the objective function to have multiple, non-isolated minima, impose no restriction on the values of the Hessian (of the objective function) and do not require the algorith...

  17. Option pricing under stochastic volatility and stochastic interest rate in the Spanish case

    OpenAIRE

    S??ez, Marc

    1995-01-01

    Among the underlying assumptions of the Black-Scholes option pricing model, those of a fixed volatility of the underlying asset and of a constant short-term riskless interest rate, cause the largest empirical biases. Only recently has attention been paid to the simultaneous effects of the stochastic nature of both variables on the pricing of options. This paper has tried to estimate the effects of a stochastic volatility and a stochastic interest rate in the Spanish...

  18. Gold Price, Stock Price and Exchange rate Nexus: The Case of India

    OpenAIRE

    Srinivasan P.

    2014-01-01

    The paper investigates the causal nexus between gold price, stock price and exchange rate in India through the Autoregressive Distributed Lag (ARDL) bounds testing approach and Granger Causality test. Using monthly time series data, the empirical analysis is carried out for the period from June 1990 to April 2014. Our analysis reveals that gold price and stock price tend to have long-run relationship with exchange rate in India. Besides, there is no evidence of stable long-run cointegration r...

  19. Corporate Governance Rating and Ownership Structure in the Case of Turkey

    OpenAIRE

    Sevin Gurarda; Emre Ozsoz; Abidin Ates

    2016-01-01

    By using corporate governance data on 22 publicly traded Turkish companies we estimate the determinants of corporate governance ratings for these companies with a focus on ownership structure. Our results show that company earnings, financial risk and firm size positively influence the corporate governance ratings (CGR) that Turkish firms receive. In the meantime, we find some weak evidence that family ownership has a negative and foreign ownership has a positive impact on CGR scores.

  20. Ventilation Rates and Airflow Pathways in Patient Rooms: A Case Study of Bioaerosol Containment and Removal.

    Science.gov (United States)

    Mousavi, Ehsan S; Grosskopf, Kevin R

    2015-11-01

    Most studies on the transmission of infectious airborne disease have focused on patient room air changes per hour (ACH) and how ACH provides pathogen dilution and removal. The logical but mostly unproven premise is that greater air change rates reduce the concentration of infectious particles and thus, the probability of airborne disease transmission. Recently, a growing body of research suggests pathways between pathogenic source (patient) and control (exhaust) may be the dominant environmental factor. While increases in airborne disease transmission have been associated with ventilation rates below 2 ACH, comparatively less data are available to quantify the benefits of higher air change rates in clinical spaces. As a result, a series of tests were conducted in an actual hospital to observe the containment and removal of respirable aerosols (0.5-10 µm) with respect to ventilation rate and directional airflow in a general patient room, and, an airborne infectious isolation room. Higher ventilation rates were not found to be proportionately effective in reducing aerosol concentrations. Specifically, increasing mechanical ventilation from 2.5 to 5.5 ACH reduced aerosol concentrations only 30% on average. However, particle concentrations were more than 40% higher in pathways between the source and exhaust as was the suspension and migration of larger particles (3-10 µm) throughout the patient room(s). Computational analyses were used to validate the experimental results, and, to further quantify the effect of ventilation rate on exhaust and deposition removal in patient rooms as well as other particle transport phenomena. PMID:26187326

  1. Determination of the enzyme reaction rate in a differential fixed-bed reactor: a case study

    Directory of Open Access Journals (Sweden)

    Baruque Filho E.A.

    2001-01-01

    Full Text Available The reaction rate of starch hydrolysis catalyzed by a glucoamylase covalently bound to chitin particles was measured in a Differential Fixed-Bed Reactor (DFBR. Under selected test conditions the initial reaction rate may represent biocatalyst activity. Some aspects which influence measurement of the initial reaction rate of an immobilized enzyme were studied: the amount of desorbed enzyme and its hydrolytic activity, the extent of pore blockage of the biocatalyst caused by substrate solution impurities and the internal and external diffusional mass transfer effects. The results showed that the enzyme glucoamylase was firmly bound to the support, as indicated by the very low amount of desorbed protein found in the recirculating liquid. Although this protein was very active, its contribution to the overall reaction rate was negligible. It was observed that the biocatalyst pores were susceptible to being blocked by the impurities of the starch solution. This latter effect was accumulative, increasing with the number of sequential experiments carried out. When the substrate solution was filtered before use, very reliable determinations of immobilized enzyme reaction rates could be performed in the DFBR. External and internal diffusional resistences usually play a significant role in fixed-bed reactors. However, for the experimental system studied, internal mass transfer effects were not significant, and it was possible to select an operational condition (recirculation flow rate value that minimized the external diffusional limitations.

  2. Clinical case management: a strategy to coordinate detection, reporting, and prosecution of elder abuse.

    Science.gov (United States)

    Luu, Arlene D; Liang, Bryan A

    2005-01-01

    Despite civil and criminal sanctions, elder abuse is a prevalent, underreported, and underprosecuted event in the United States. Traditional reporting legislation and common law remedies have had minimal effect on the incidence and prevalence of elder abuse. The epidemic nature of elder abuse is projected to increase exponentially as the elderly population grows disproportionately over the next several decades. The fragmented system of detecting, reporting, and prosecuting this abuse across a wide range of medical and legal settings creates a poor structure to effectively allow a potentially abused patient to have his/her abuse circumstance communicated to the relevant parties to protect the patient, have his/her situation reported and investigated, and, if necessary, have the perpetrator brought to justice. Emergency rooms and other facilities where elders present for care should be staffed by clinically trained persons who have familiarity interacting with patients and providers across settings of care, and who are trained to detect and report abuse. Nursing case managers fill this role well because they are able to coordinate efforts among acute and long-term care facilities while also being able to supply patients with legal and clinical information about elder abuse. In addition they may support prosecution efforts through their clinical observations and expertise. Hence, clinical case managers are able to coordinate efforts lacking in the current system to effectively evaluate, report, protect, and arrange for relevant services for the patient. Through clinical and special training in elder abuse, nursing case managers can provide support to prosecution efforts against the perpetrators of this most egregious crime. PMID:16838454

  3. [Tuberculosis in 2015: From diagnosis to the detection of multiresistant cases].

    Science.gov (United States)

    Hervé, C; Bergot, E; Veziris, N; Blanc, F-X

    2015-10-01

    Incidence of pulmonary tuberculosis, a contagious infectious disease, decreases in France with 4934 reported cases in 2013. Tuberculosis remains a global health problem as smear is positive in only 50% cases and culture methods require time. In such a context, genotypic diagnostic tools such as Xpert® MTB/RIF gained interest. This rapid and simple-to-use nucleic acid amplification test allows a diagnosis in two hours and prevents further invasive investigations in pulmonary and mediastinal tuberculosis. Because of its low sensitivity, it cannot be used in pleural fluid. Indirect immunologic tests are of no use to diagnose active tuberculosis disease. Another current area of interest is the emergence of resistant tuberculosis. In France, approximately 100 cases of multidrug resistant tuberculosis and a few extensively drug resistant tuberculosis have been reported in 2014. Even though these forms of tuberculosis are imported, it is crucial to identify hazardous situations and to optimize care of these patients. Xpert® MTB/RIF is again of marked interest here as it detects rifampin resistance with a 95% sensitivity and a 98% specificity. Interpretation of genotypic tests such as Genotype® MTBDR or Xpert® MTB/RIF depends on known detected mutations, although they do not always have a clinical or phenotypic expression. In multidrug resistant tuberculosis, the new drug bedaquiline obtained approval for temporarily use in combination with other molecules when there is no other treatment option. Results of bedaquiline are encouraging but adverse events like QT prolongation or the development of new specific drug resistance should convince clinicians to use it with caution. PMID:26169235

  4. The Experience of Detecting a Case of Plagiarism in Hepatitis Monthly

    Directory of Open Access Journals (Sweden)

    Zahra Goodarzi

    2008-08-01

    Full Text Available Plagiarism is the unauthorized use or close imitation of the language and thoughts of another author and the representation of them as one's own original work (1. The National Library of Medicine (NLM defines a duplicate publication as one that 'substantially duplicates another article without acknowledgement' (2. Scientific misconduct may take place simply out of reasons of reputation - academic scientists are under pressure to produce publications in peer-reviewed journals. Alternatively, there may be commercial or political motivations where the financial or political success of a project depends on publishing evidence of efficacy (1, 3. While plagiarism in scholarship and journalism has a centuries-old history, the development of the Internet, where articles appear as electronic text, has made the physical act of copying the work of others much easier, simply by copying and pasting text from one web page to another (1, 2. The ease with which electronic text can be reproduced from online sources has lured a number of reporters into acts of plagiarism: Journalists have been caught "copying-and-pasting" articles and text from a number of websites (1, 4, 5. Although detecting the cases of plagiarism is very complex and challenging, we have to consider plagiarism as the first part of the manuscript review process (6. In Iran, we have neither an online tool for detecting suspicious and doubtful articles, nor a national database for including cases of plagiarism. So what can we do?We introduce a case of plagiarism in Hepatitis Monthly and present some valuable ways to tackle this complicated problem since we believe that prevention of duplicate publication can be achieved through increasing editors' awareness and reviewers' knowledge.

  5. Multiple Kernel Learning for Heterogeneous Anomaly Detection: Algorithm and Aviation Safety Case Study

    Science.gov (United States)

    Das, Santanu; Srivastava, Ashok N.; Matthews, Bryan L.; Oza, Nikunj C.

    2010-01-01

    The world-wide aviation system is one of the most complex dynamical systems ever developed and is generating data at an extremely rapid rate. Most modern commercial aircraft record several hundred flight parameters including information from the guidance, navigation, and control systems, the avionics and propulsion systems, and the pilot inputs into the aircraft. These parameters may be continuous measurements or binary or categorical measurements recorded in one second intervals for the duration of the flight. Currently, most approaches to aviation safety are reactive, meaning that they are designed to react to an aviation safety incident or accident. In this paper, we discuss a novel approach based on the theory of multiple kernel learning to detect potential safety anomalies in very large data bases of discrete and continuous data from world-wide operations of commercial fleets. We pose a general anomaly detection problem which includes both discrete and continuous data streams, where we assume that the discrete streams have a causal influence on the continuous streams. We also assume that atypical sequence of events in the discrete streams can lead to off-nominal system performance. We discuss the application domain, novel algorithms, and also discuss results on real-world data sets. Our algorithm uncovers operationally significant events in high dimensional data streams in the aviation industry which are not detectable using state of the art methods

  6. Real-time porphyrin detection in plaque and caries: a case study

    Science.gov (United States)

    Timoshchuk, Mari-Alina I.; Ridge, Jeremy S.; Rugg, Amanda L.; Nelson, Leonard Y.; Kim, Amy S.; Seibel, Eric J.

    2015-02-01

    An ultrathin scanning fiber endoscope, originally developed for cancer diagnosis, was used in a case study to locate plaque and caries. The imaging system incorporated software mitigation of background auto-fluorescence (AF). In conventional fluorescence imaging, varying AF across a tooth surface can mask low-level porphyrin signals. Laser-induced auto-fluorescence signals of dental tissue excited using a 405-nm laser typically produce fluorescence over a wavelength range extending from 440-nm to 750-nm. Anaerobic bacterial metabolism produces various porphyrin species (eg. protoporphyrin IX) that are located in carious enamel, dentin, gingivitis sites, and plaque. In our case study, these porphyrin deposits remained as long as one day after prophylaxis. Imaging the tooth surface using 405-nm excitation and subtracting the natural AF enhances the image contrast of low-level porphyrin deposits, which would otherwise be masked by the high background AF. In a case study, healthy tissues as well as sites of early and advanced caries formations were scanned for visual and quantitative signs of red fluorescence associated with porphyrin species using a background mitigation algorithm. Initial findings show increasing amplitudes of red fluorescence as caries severity increases from early to late stages. Sites of plaque accumulation also displayed red fluorescence similar to that found in carious dental tissue. The use of real-time background mitigation of natural dental AF can enhance the detection of low porphyrin concentrations that are indicators of early stage caries formation.

  7. Sensitivity of the Dengue Surveillance System in Brazil for Detecting Hospitalized Cases

    Science.gov (United States)

    2016-01-01

    We evaluated the sensitivity of the dengue surveillance system in detecting hospitalized cases in ten capital cities in Brazil from 2008 to 2013 using a probabilistic record linkage of two independent information systems hospitalization (SIH-SUS) adopted as the gold standard and surveillance (SINAN). Sensitivity was defined as the proportion of cases reported to the surveillance system amid the suspected hospitalized cases registered in SIH-SUS. Of the 48,174 hospitalizations registered in SIH-SUS, 24,469 (50.7%) were reported and registered in SINAN, indicating an overall sensitivity of 50.8% (95%CI 50.3–51.2). The observed sensitivity for each of the municipalities included in the study ranged from 22.0% to 99.1%. The combination of the two data sources identified 71,161 hospitalizations, an increase of 97.0% over SINAN itself. Our results allowed establishing the proportion of underreported dengue hospitalizations in the public health system in Brazil, highlighting the use of probabilistic record linkage as a valuable tool for evaluating surveillance systems. PMID:27192405

  8. Early detection and percutaneous transluminal angioplasty of hemodialysis fistula stenoses: correlation with venous dialysis pressure and urea recirculation rate=20

    International Nuclear Information System (INIS)

    To evaluate the usefulness of venous dialysis pressure (VDP) and urea recirculation rate (URR) for the early detection of venous stenoses, the most common cause of hemodialysis fistular failure. To correlate the outcome of early percutaneous transluminal angioplasty (PTA) with VDP and URR after PTA. Eighty one chronic hemodialysis patients were monitored for VDP and URR during each session of hemodialysis treatment. Twenty-eight patients with elevated VDP and URR underwent fistulography, and the results were prospectively analysed. PTA was performed in twelve discrete stenoses (>70% reduction of the lumen) in six patients. Following PTA, VDP and URR were reevaluated. Fistulogramas showed that 15 of 28 patients had 22 stenoses. All of these lesions occurred in the proximal vein of an arteriovenous fistula, showing less than 50% reduction of the lumen in six stenoses, 50-70% in four, more than 70% in twelve, and no complete occlusion. Stenosis length was less than 1cm in twelve lesions, 1-3cm in seven, and 3-6cm in three. In 11 of 12 stenoses, angioplasty was successful with no significant residual stenosis remaining. After PTA, mean VDP and URR fell significantly: 117.8±20.6mmHg to 99.8±8.2mmHg(p=3D0.025), and 22.9±16.1 to 7.6±7.2(p=3D0.014), respectively. Early detection and early PTA of venous stenoses led to a high initial patency rate when used in conjuction with elective measurement of VDP and URR. After PTA, VDP and URR fell significantly, and there was close correlation with the outcome of PTA

  9. Effect of increasing mining rate on longwall coal mining - Western donbass case study

    Science.gov (United States)

    Sdvyzhkova, Olena; Patyńska, Renata

    2016-03-01

    This paper presents the problems associated with the rapid change of the rock stress-strain state in terms of increasing the rate of coal mining. Parameters of the roof collapse are determined depending on the rate of a longwall advancing under conditions of poor rocks. Statistical data are processed to obtain a general trend concerning the mining rate impact on the roof collapse. The statistical strength theory is applied to explain the increase in mined-out space and the size of hanging roof behind a coal face. Numerical simulation is carried out to determine a critical size of mined-out space that provokes a roof collapse. The area of yielded rocks is outlined using the criterion developed taking into account the rate of longwall advancing. A general regularity is obtained to determine the roof collapse parameters. The developed technics gives a possibility to predict the moment of general roof collapse at the initial stage of longwalling to prevent the negative effect of the rapid stress redistribution provoking joints propagation and intensive gas release. The estimation of the rock stress-strain state considering the rate of mining operations can be useful for tasks related to a new technology implementation. The statistical strength theory and failure criterion applied together provides adequate planning of mining activities and the assessment of natural hazards.

  10. Predicted detection rates of regional-scale meteorite impacts on Mars with the InSight short-period seismometer

    Science.gov (United States)

    Teanby, N. A.

    2015-08-01

    In 2016 NASA will launch the InSight discovery-class mission, which aims to study the detailed internal structure of Mars for the first time. Short- and long-period seismometers form a major component of InSight's payload and have the potential to detect seismic waves generated by meteorite impacts. Large globally detectable impact events producing craters with diameters of ∼ 100 m have been investigated previously and are likely to be rare (Teanby, N.A., Wookey, J. [2011]. Phys. Earth Planet. Int. 186, 70-80), but smaller impacts producing craters in the 0.5-20 m range are more numerous and potentially occur sufficiently often to be detectable on regional scales (≲1000 km). At these distances, seismic waves will have significant high frequency content and will be suited to detection with InSight's short-period seismometer SEIS-SP. In this paper I estimate the current martian crater production function from observations of new craters (Malin, M.C. et al. [2006]. Science 314, 1573-1577; Daubar, I.J. et al. [2013]. Icarus 225, 506-516), model results (Williams, J.P., Pathare, A.V., Aharonson, O. [2014]. Icarus 235, 23-36), and standard isochrons (Hartmann, W.K. [2005]. Icarus 174, 294-320). These impact rates are combined with an empirical relation between impact energy, source-receiver distance, and peak seismogram amplitude, derived from a compilation of seismic recordings of terrestrial and lunar impacts, chemical explosions, and nuclear tests. The resulting peak seismogram amplitude scaling law contains significant uncertainty, but can be used to predict impact detection rates. I estimate that for a short-period instrument, with a noise spectral density of 10-8 ms-2 Hz-1/2 in the 1-16 Hz frequency band, approximately 0.1-30 regional impacts per year should be detectable with a nominal value of 1-3 impacts per year. Therefore, small regional impacts are likely to be a viable source of seismic energy for probing Mars' crustal and upper mantle structure. This is

  11. RAPID REAL TIME PCR BASED DETECTION OF CELL COUNT IN CASE OF URINARY TRACT INFECTION

    Directory of Open Access Journals (Sweden)

    Poulomi Nandy

    2013-01-01

    Full Text Available Microbial identification and antimicrobial susceptibility testing methods currently used in clinical microbiology laboratories require at least two to three days because they rely on the growth and isolation of micro-organisms. This long, but necessary, delay has enormous consequences on prophylactic usage of antimicrobial drugs. This study was an attempt to reduce this detection time span. Taq Man Real Time PCR has been used as an important tool in the differentiation of Gram nature of bacteria present in UTI patients that allows detection of spiked bacterial 16S rDNA from urine samples within a short span of 5h and also gives us the corresponding cell count of both/either Gram positive and negative organisms present. A standard curve was generated which was used to determine the cell count of control as well as patient samples. Detection could be done in the range of 103 to 106 cells/mL Patient samples screened clustered either in the allele 1 or allele 2 axes, depending on majority concentration of Gram nature of the micro-organisms. The cell counts for control individuals were scattered within 0 to 102, while very few in the range of 104. The case was just reverse for patient group, where most of the points were scattered within 104 to 108. Thus the optimal selection of appropriate antimicrobials (depending on the gram nature by clinicians, will be gradually improved as an increasing number of rapid molecular diagnostic tools for the detection, identification and characterization of infectious agents become commercially available.

  12. Evaluation of bacterial contamination rate of the anterior chamber during phacoemulsification surgery using an automated microbial detection system

    Institute of Scientific and Technical Information of China (English)

    Ibrahim; Kocak; Funda; Kocak; Bahri; Teker; Ali; Aydin; Faruk; Kaya; Hakan; Baybora

    2014-01-01

    ·AIM: To assess the incidence of anterior chamber bacterial contamination during phacoemulsification surgery using an automated microbial detection system(BacT/Alert).·METHODS: Sixty-nine eyes of 60 patients who had uneventful phacoemulsification surgery, enrolled in this prospective study. No prophylactic topical or systemic antibiotics were used before surgery. After antisepsis with povidone-iodine, two intraoperative anterior chamber aqueous samples were obtained, the first whilst entering anterior chamber, and the second at the end of surgery. BacT/Alert culture system was used to detect bacterial contamination in the aqueous samples.·RESULTS: Neither aqueous samples obtained at the beginning nor conclusion of the surgery was positive for microorganisms on BacT/Alert culture system. The rate of bacterial contamination during surgery was 0%. None of the eyes developed acute-onset endophthalmitis after surgery.· CONCLUSION: In this study, no bacterial contamination of anterior chamber was observed during cataract surgery. This result shows that meticulous surgical preparation and technique can prevent anterior chamber contamination during phacoemulsification cataract surgery.

  13. Detection of Driver Drowsiness Using Wavelet Analysis of Heart Rate Variability and a Support Vector Machine Classifier

    Directory of Open Access Journals (Sweden)

    Gang Li

    2013-12-01

    Full Text Available Driving while fatigued is just as dangerous as drunk driving and may result in car accidents. Heart rate variability (HRV analysis has been studied recently for the detection of driver drowsiness. However, the detection reliability has been lower than anticipated, because the HRV signals of drivers were always regarded as stationary signals. The wavelet transform method is a method for analyzing non-stationary signals. The aim of this study is to classify alert and drowsy driving events using the wavelet transform of HRV signals over short time periods and to compare the classification performance of this method with the conventional method that uses fast Fourier transform (FFT-based features. Based on the standard shortest duration for FFT-based short-term HRV evaluation, the wavelet decomposition is performed on 2-min HRV samples, as well as 1-min and 3-min samples for reference purposes. A receiver operation curve (ROC analysis and a support vector machine (SVM classifier are used for feature selection and classification, respectively. The ROC analysis results show that the wavelet-based method performs better than the FFT-based method regardless of the duration of the HRV sample that is used. Finally, based on the real-time requirements for driver drowsiness detection, the SVM classifier is trained using eighty FFT and wavelet-based features that are extracted from 1-min HRV signals from four subjects. The averaged leave-one-out (LOO classification performance using wavelet-based feature is 95% accuracy, 95% sensitivity, and 95% specificity. This is better than the FFT-based results that have 68.8% accuracy, 62.5% sensitivity, and 75% specificity. In addition, the proposed hardware platform is inexpensive and easy-to-use.

  14. Estimation of mutation rates from paternity cases using a Bayesian network

    DEFF Research Database (Denmark)

    Vicard, P.; Dawid, A.P.; Mortera, J.; Lauritzen, Steffen Lilholt

    We present a statistical model and methodology for making inferences about mutation rates from paternity casework. This takes proper account of a number of sources of potential bias, including hidden mutation, incomplete family triplets, uncertain paternity status and differing maternal and...... paternal mutation rates, while allowing a wide variety of mutation models. A Bayesian network is constructed to facilitate computation of the likelihood function for the mutation parameters. It can process both full and summary genotypic information, from both complete putative father-mother-child triplets...

  15. Detection efficiency of the VLF World-Wide Lightning Location Network (WWLLN: initial case study

    Directory of Open Access Journals (Sweden)

    C. J. Rodger

    2006-12-01

    Full Text Available An experimental Very Low Frequency (VLF World-Wide Lightning Location Network (WWLLN has been developed through collaborations with research institutions across the world, providing global real-time locations of lightning discharges. As of April 2006, the network included 25 stations providing coverage for much of the Earth. In this paper we examine the detection efficiency of the WWLLN by comparing the locations from this network with lightning location data purchased from a commercial lightning location network operating in New Zealand. Our analysis confirms that WWLLN favours high peak current return stroke lightning discharges, and that discharges with larger currents are observed by more stations across the global network. We then construct a first principles detection efficiency model to describe the WWLLN, combining calibration information for each station with theoretical modelling to describe the expected amplitudes of the VLF sferics observed by the network. This detection efficiency model allows the prediction of the global variation in WWLLN lightning detection, and an estimate of the minimum CG return stroke peak current required to trigger the network. There are strong spatial variations across the globe, primarily due to station density and sensitivity.

    The WWLLN is currently best suited to study the occurrence and impacts of high peak-current lightning. For example, in 2005 about 12% of the global elve-producing lightning will have been located by the network. Since the lightning-EMP which produce elves has a high mean rate (210 per minute it has the potential to significantly influence the ionosphere on regional scales.

  16. Human care system for heart-rate and human-movement trajectory in home and its application to detect mental disease

    Science.gov (United States)

    Hata, Yutaka; Kanazawa, Seigo; Endo, Maki; Tsuchiya, Naoki; Nakajima, Hiroshi

    2012-06-01

    This paper proposes a heart rate monitoring system for detecting autonomic nervous system by the heart rate variability using an air pressure sensor to diagnose mental disease. Moreover, we propose a human behavior monitoring system for detecting the human trajectory in home by an infrared camera. In day and night times, the human behavior monitoring system detects the human movement in home. The heart rate monitoring system detects the heart rate in bed in night time. The air pressure sensor consists of a rubber tube, cushion cover and pressure sensor, and it detects the heart rate by setting it to bed. It unconstraintly detects the RR-intervals; thereby the autonomic nervous system can be assessed. The autonomic nervous system analysis can examine the mental disease. While, the human behavior monitoring system obtains distance distribution image by an infrared camera. It classifies adult, child and the other object from distance distribution obtained by the camera, and records their trajectories. This behavior, i.e., trajectory in home, strongly corresponds to cognitive disorders. Thus, the total system can detect mental disease and cognitive disorders by uncontacted sensors to human body.

  17. When Does Variable Rate Technology for Agricultural Sprayers Pay? A Case Study for Cotton Production in Tennessee

    OpenAIRE

    Mooney, Daniel; Larson, James; Roberts, Roland; English, Burton

    2009-01-01

    Producers interested in precision agriculture lack information on the profitability of variable rate technology (VRT) systems for agricultural sprayers. A partial budgeting framework was developed to evaluate the level of input savings required to pay for investments in VRT. To illustrate this framework, a case study for cotton production in Tennessee is provided. Ownership and information costs were determined for two commerciallyavailable VRT systems and compared to extension recommended in...

  18. The analysis of a case rate a skin melanoma in the Samara region for 1999-2009

    Directory of Open Access Journals (Sweden)

    Kozlov S.V.

    2011-06-01

    Full Text Available In article one of oncology problems — a skin melanoma is surveyed. The theme urgency proves to be true that annually the case rate of patients with an oncologic pathology is constantly enlarged. One of oncology problems still has a skin melanoma. The work purpose is studying of a case rate by a skin melanoma in large industrial area on an example of the Samara region over the last 10 years. In article one of oncology problems — a skin melanoma is surveyed. For the task in view decision following materials and methods were used: primary registration documentation for 11 years (1999-2009 About for the first time taped disease a skin melanoma, annual reports of the Samara regional clinical oncologic dispensary, annual statistical reports of the State statistical committee, bureau MSE annual reports. At processing and the forecast of results of research following statistical methods — an extrapolation method, model of linear regress were used. Reliability of the taped pattern of dynamics was defined by means of an error of regress with the subsequent definition t and p. The received results testify to growth of a case rate of all population of the Samara region at the expense of the senior age groups. According to the analysis the invalid population is more often is ill. Conclusions are drawn on appreciable influence on occurrence of this pathology occurring in an organism involutes processes, necessity of carrying out of sanitary-educational work, carrying out of additional profound inspection among the population with high level of a case rate

  19. Exchange rate of the US dollar and the J curve: the case of oil exporting countries

    International Nuclear Information System (INIS)

    This study examines the effects of changes in the exchange rate of the US dollar on the trade balances of three oil-exporting countries, namely Iran, Venezuela and Saudi Arabia. An exchange rate pass-through model is applied to allow changes in the exchange rate of the dollar to affect prices of traded goods. Then, the impact of changes in prices on the quantities of imports and exports of these economies is estimated. The results suggest a partial exchange rate pass-through to these countries' import and export prices in terms of the US dollar. While the three countries raise the price of their primary export (namely crude oil) in response to a depreciation of the dollar, Saudi Arabia's long-run pricing strategy in securing a larger market share stands in contrast to that of the two other OPEC members. The sum of the estimated long-run price elasticities of demand for imports and exports is found to exceed unity for Iran and Venezuela, but less than unity for Saudi Arabia. (author)

  20. Exchange rate of the US dollar and the J curve. The case of oil exporting countries

    International Nuclear Information System (INIS)

    This study examines the effects of changes in the exchange rate of the US dollar on the trade balances of three oil-exporting countries, namely Iran, Venezuela and Saudi Arabia. An exchange rate pass-through model is applied to allow changes in the exchange rate of the dollar to affect prices of traded goods. Then, the impact of changes in prices on the quantities of imports and exports of these economies is estimated. The results suggest a partial exchange rate pass-through to these countries' import and export prices in terms of the US dollar. While the three countries raise the price of their primary export (namely crude oil) in response to a depreciation of the dollar, Saudi Arabia's long-run pricing strategy in securing a larger market share stands in contrast to that of the two other OPEC members. The sum of the estimated long-run price elasticities of demand for imports and exports is found to exceed unity for Iran and Venezuela, but less than unity for Saudi Arabia

  1. Extension of the sum rule for the transition rates between multiplets to the multiphoton case

    CERN Document Server

    Solovyev, D; Volotka, A; Plunien, G

    2010-01-01

    The sum rule for the transition rates between the components of two multiplets, known for the one-photon transitions, is extended to the multiphoton transitions in hydrogen and hydrogen-like ions. As an example the transitions 3p-2p, 4p-3p and 4d-3d are considered. The numerical results are compared with previous calculations.

  2. Exchange rate regimes and shocks asymmetry: the case of the accession countries

    Czech Academy of Sciences Publication Activity Database

    Babetskii, Ian; Boone, J.; Maurel, M.

    2004-01-01

    Roč. 32, č. 2 (2004), s. 212-229. ISSN 0147-5967 Institutional research plan: CEZ:AV0Z7085904 Keywords : EU enlargement * exchange rate regimes * optimal currency area criteria Subject RIV: AH - Economics Impact factor: 0.836, year: 2004

  3. Geological reasons causing rapid rate decline. A case study of Field T, Russia

    International Nuclear Information System (INIS)

    The paper introduces the complex approach to determining possible geological reasons causing rate decline in the wells of Field T, Russia. Therefore, possible geological reasons are sequentially considered and were divided into three main groups: 1) rate decline due to poorer reservoir quality; 2) rate decline due to facies lateral substitution; 3) rate decline due to active fault tectonics. The most appropriate facies models were constructed on the basis of all available data. Besides, in this study, core, well logging, seismic and well test data were integrated for the fullest reservoir characterization. The core from several recently drilled wells was described in detail to determine clue features. Further, seismic data were interpreted: structural interpretation, including faults and attribute analysis, was implemented. Appropriate electrofacies models were chosen as well. At the final stage, all previously-mentioned data were integrated with appropriate facies model construction. However, as it turned out later, the facies model was not the key factor affecting the rapid decline that appeared in some wells. It is suggested that very proximal faults can be a possible explanation. To confirm this suggestion, well test data were additionally used and both analytical and numerical methods were applied to show the consistency of this theory

  4. Predicting Bank CAMELS and S&P Ratings. The Case of Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Derviz, Alexis; Podpiera, J.

    2008-01-01

    Roč. 44, č. 1 (2008), s. 87-101. ISSN 1540-496X Institutional research plan: CEZ:AV0Z10750506 Keywords : bank rating * CAMELS * ordered logit * panel data Subject RIV: AH - Economics Impact factor: 0.611, year: 2008

  5. Measuring inconsistencies can lead you forward. The case of imageability and concreteness ratings

    Directory of Open Access Journals (Sweden)

    SaraDellantonio

    2014-07-01

    Full Text Available According to the traditional view, both imageability and concreteness ratings reflect the way word meanings rely on information mediated by the senses. As a consequence, the two measures should and do correlate. The link between these two indexes was already hypothesized and demonstrated by Paivio, Yuille & Madigan (1968 in a seminal article, where they introduced the idea of imageability ratings for the first time. However, in this first study, they also noted a contrasting pattern in the ratings for imageability and concreteness with some words that refer to affective attitudes or emotional states receiving high imageability but low concreteness ratings. Recent studies confirm this inconsistency (e.g., Altarriba & Bauer, 2004 leading to the claim that emotion words form a particular class of terms different from both concrete and abstract words. Here we use the MRC psycholinguistic database to show that the there are other classes of terms for which imageability and concreteness are uncorrelated. We show that the common feature of these word classes is that they directly or indirectly refer to proprioceptive, interoceptive, or affective states, i.e. to internal, body-related, sensory experiences. Thus, imageability and concreteness can no longer be considered interchangeable constructs; rather, imageability is a different, and perhaps more interesting, measure: it not only reflects the ease with which memories of external events come to mind, as previously hypothesized, but also reflects the ease with which memories of internal events come to mind.

  6. Indoor terrestrial gamma dose rate mapping in France: a case study using two different geostatistical models.

    Science.gov (United States)

    Warnery, E; Ielsch, G; Lajaunie, C; Cale, E; Wackernagel, H; Debayle, C; Guillevic, J

    2015-01-01

    Terrestrial gamma dose rates show important spatial variations in France. Previous studies resulted in maps of arithmetic means of indoor terrestrial gamma dose rates by "departement" (French district). However, numerous areas could not be characterized due to the lack of data. The aim of our work was to obtain more precise estimates of the spatial variability of indoor terrestrial gamma dose rates in France by using a more recent and complete data base and geostatistics. The study was based on the exploitation of 97,595 measurements results distributed in 17,404 locations covering all of France. Measurements were done by the Institute for Radioprotection and Nuclear Safety (IRSN) using RPL (Radio Photo Luminescent) dosimeters, exposed during several months between years 2011 and 2012 in French dentist surgeries and veterinary clinics. The data used came from dosimeters which were not exposed to anthropic sources. After removing the cosmic rays contribution in order to study only the telluric gamma radiation, it was decided to work with the arithmetic means of the time-series measurements, weighted by the time-exposure of the dosimeters, for each location. The values varied between 13 and 349 nSv/h, with an arithmetic mean of 76 nSv/h. The observed statistical distribution of the gamma dose rates was skewed to the right. Firstly, ordinary kriging was performed in order to predict the gamma dose rate on cells of 1*1 km(2), all over the domain. The second step of the study was to use an auxiliary variable in estimates. The IRSN achieved in 2010 a classification of the French geological formations, characterizing their uranium potential on the bases of geology and local measurement results of rocks uranium content. This information is georeferenced in a map at the scale 1:1,000,000. The geological uranium potential (GUP) was classified in 5 qualitative categories. As telluric gamma rays mostly come from the progenies of the (238)Uranium series present in rocks, this

  7. 医生睡眠问题的检出率及相关因素%Detection Rate and Related Factors of Doctor Sleep Problems

    Institute of Scientific and Technical Information of China (English)

    王红; 孟彬; 郭昕; 于纪泽

    2015-01-01

    Objective To investigate the doctor rate of sleep problems and related factors.Methods Cluster sampling and others in our hospital 187 cases of doctor completed general situation questionnaire,Zung's depression self rating scale,the Zung's anxiety self-assessment scale and standardization of sleep problems [trouble fal ing asleep (DIS),dif iculty maintaining sleep (DMS)and early awakening (EMA)].Results The doctor DIS and DMS,EMA and any sleep problems the detection rate of 11.5%,11.7%,10.5%and 11.7%respectively;Poor family relationship,practice for more than two years,depression and anxiety is a risk factor for doctors sleep problems (OR=1.86~1.86,P 0.025)OR less.Conclusion The doctor sleep problem detection rate is higher than the general population,it is related to social psychological factors and practice time.%目的:调查医生睡眠问题的检出率及相关因素。方法整群抽取我院和其他医院187例医生完成一般情况问卷、Zung氏抑郁自评量表、Zung氏焦虑自评量表和标准化的睡眠问题[入睡困难(DIS)、睡眠维持困难(DMS)和早醒(EMA)]评估。结果医生DIS、DMS、EMA和任一睡眠问题的检出率分别为11.5%、11.7%、10.5%和20.8%;家庭关系差、执业超过2年、抑郁和焦虑是医生睡眠问题的危险因素(OR=1.86~5.12,≤0.025)。结论医生睡眠问题的检出率高于普通人群,其发生与社会心理因素及执业时间有关。

  8. Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

    Science.gov (United States)

    Andreassen, Ole A.; Thompson, Wesley K.; Schork, Andrew J.; Ripke, Stephan; Mattingsdal, Morten; Kelsoe, John R.; Kendler, Kenneth S.; O'Donovan, Michael C.; Rujescu, Dan; Werge, Thomas; Sklar, Pamela; Roddey, J. Cooper; Chen, Chi-Hua; McEvoy, Linda; Desikan, Rahul S.; Djurovic, Srdjan; Dale, Anders M.

    2013-01-01

    Several lines of evidence suggest that genome-wide association studies (GWAS) have the potential to explain more of the “missing heritability” of common complex phenotypes. However, reliable methods to identify a larger proportion of single nucleotide polymorphisms (SNPs) that impact disease risk are currently lacking. Here, we use a genetic pleiotropy-informed conditional false discovery rate (FDR) method on GWAS summary statistics data to identify new loci associated with schizophrenia (SCZ) and bipolar disorders (BD), two highly heritable disorders with significant missing heritability. Epidemiological and clinical evidence suggest similar disease characteristics and overlapping genes between SCZ and BD. Here, we computed conditional Q–Q curves of data from the Psychiatric Genome Consortium (SCZ; n = 9,379 cases and n = 7,736 controls; BD: n = 6,990 cases and n = 4,820 controls) to show enrichment of SNPs associated with SCZ as a function of association with BD and vice versa with a corresponding reduction in FDR. Applying the conditional FDR method, we identified 58 loci associated with SCZ and 35 loci associated with BD below the conditional FDR level of 0.05. Of these, 14 loci were associated with both SCZ and BD (conjunction FDR). Together, these findings show the feasibility of genetic pleiotropy-informed methods to improve gene discovery in SCZ and BD and indicate overlapping genetic mechanisms between these two disorders. PMID:23637625

  9. Managing Foreign Exchange Rate Exposure A Case Study in Sinochem International Corporate

    OpenAIRE

    Ru, Qing

    2008-01-01

    This dissertation is purposed to seek an exploration on the measurement and management foreign exchange exposure and the application in China. Although China has a tremendous improvement on economy in the recent three decades, its financial derivatives market is still undeveloped. Limited available derivatives constrain the corporate foreign exchange exposures management. A case study of Sinochem International Corporation is present for the research. By examining the firm's hedging data, t...

  10. Transthoracic fine needle aspiration biopsy: diagnostic rate and complications in 1000 cases

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sun Mi; Jeon, Seok Chol; Bae, Oh Keun; Choi, Yo Won; Hahm, Chang Kok [School of Medicine, Hanyang University Hospital, Seoul (Korea, Republic of); Kim, Chang Ho [InJe University, Pusan (Korea, Republic of); You, Won Don [Armed Forces General Hospital, Seoul (Korea, Republic of)

    1994-11-15

    Transthoracic fine needle aspiration biopsy is a widely practiced technique in the investigation of the lung and mediastinal masses because of its safety, reliability and accuracy. We report the diagnostic accuracy of the transthoracic fine needle aspiration biopsy and the frequency of its complications which required treatment. We analyzed 1000 transthoracic needle aspiration biopsies which were performed in 986 patients with 993 chest lesions. Aspiration biopsies were obtained with Westcott needles (20G or 22G) under the fluoroscopic guidance. Final diagnosis was made with operation, bronchoscopy, sputum study, biopsy of other sites and the clinical course of the patient. We analyzed diagnostic yields of aspiration biopsy and the frequency of the complication requiring treatment. The sensitivity was 87.6 % in benign diseases and 95.8 % in malignant diseases. Pneumothorax was the most frequent complication, which required pig-tail catheter insertion in 36 cases or thoracotomy in six cases. In 36 cases, minimal hemoptysis developed which did not require treatments. We obtained relatively high sensitivities of malignant and benign lesions using transthoracic fine needle aspiration biopsy and the frequency of the complications requiring treatment was very low. Transthoracic fine needle aspiration biopsy is a valuable diagnostic method in the thoracic lesions.

  11. Transthoracic fine needle aspiration biopsy: diagnostic rate and complications in 1000 cases

    International Nuclear Information System (INIS)

    Transthoracic fine needle aspiration biopsy is a widely practiced technique in the investigation of the lung and mediastinal masses because of its safety, reliability and accuracy. We report the diagnostic accuracy of the transthoracic fine needle aspiration biopsy and the frequency of its complications which required treatment. We analyzed 1000 transthoracic needle aspiration biopsies which were performed in 986 patients with 993 chest lesions. Aspiration biopsies were obtained with Westcott needles (20G or 22G) under the fluoroscopic guidance. Final diagnosis was made with operation, bronchoscopy, sputum study, biopsy of other sites and the clinical course of the patient. We analyzed diagnostic yields of aspiration biopsy and the frequency of the complication requiring treatment. The sensitivity was 87.6 % in benign diseases and 95.8 % in malignant diseases. Pneumothorax was the most frequent complication, which required pig-tail catheter insertion in 36 cases or thoracotomy in six cases. In 36 cases, minimal hemoptysis developed which did not require treatments. We obtained relatively high sensitivities of malignant and benign lesions using transthoracic fine needle aspiration biopsy and the frequency of the complications requiring treatment was very low. Transthoracic fine needle aspiration biopsy is a valuable diagnostic method in the thoracic lesions

  12. Gate of radioactivity detection. guide on the methodology to follow in the case of activating

    International Nuclear Information System (INIS)

    Most of operators of waste treatment centers are tooled up with gates of radioactivity detection. To meet to a need of clarification of procedures that can be followed during an activating of gates, cards have been established by a work group constituted by representatives of different entities concerned by the subject. These cards propose procedures to follow in the case of activating of gates in respecting the running legislation in the field of environment protection and radiation protection. Annexe with the terms mentioned in the cards are given, a lexicon on radioactivity and a list of organisms able and licensed to provide monitoring for the workers protection against the ionizing radiations. (N.C.)

  13. Congenital abdominal dumbbell fashion neuroblastoma with invasion of spinal canal detected by ultrasonography - case report

    International Nuclear Information System (INIS)

    A case of congenital abdominal dumbbell fashion neuroblastoma with invasion of the spinal canal detected by ultrasonography (US) is presented. A 3-week-old male neonate was admitted to the hospital with a palpable mass in the left lumbar region. Ultrasound examination was performed on the same day. It disclosed a pathologic mass filling the left side of the retroperitoneal space - displacing laterally and inferiorly the left kidney. The second part of the tumor was located above the Gerot's fascia in the muscles and infiltrated the tomography scanning confirmed the presence of solid masses in these locations. Urinary excretion of vanillin-mandelic acid (VMA) was within normal range, ferritin level was elevated (447 μg/ml). Bone scintigraphy showed metastases to the left clavicle. There were no changes in bone marrow. Diagnosis of an undifferentiated malignant neuroblastoma was established in histopathological examination. Spinal ultrasonography is highly recommended in neonates and infants with retroperitoneal tumors. (author)

  14. Early detection and response for measles and rubella cases through the (Nursery) School Absenteeism Surveillance System in Ibaraki Prefecture.

    Science.gov (United States)

    Watanabe, Miki; Kurita, Junko; Takagi, Takeshi; Nagata, Noriko; Nagasu, Natsuki; Sugawara, Tamie; Ohkusa, Yasushi

    2016-01-01

    Objectives In Ibaraki Prefecture, all (nursery) schools have joined the (Nursery) School Absenteeism Surveillance System (hereafter denoted as (N)SASSy), which is operated by the Japan School Health Association to monitor the prevalence of infectious diseases, the early detection and response for outbreaks, and prevention of large outbreaks. Prefectural government officers also utilize it as a control measure for infectious diseases. In particular, when cases of measles or rubella are registered, (N)SASSy sends e-mails automatically to prefectural government officers to activate control measures. This paper summarizes administrative responses by prefectural government officers for measles or rubella cases using (N)SASSy and discusses the future challenges.Methods We summarized registration, detection, and first response data for measles or rubella cases in (N)SASSy and compared the number of detected and reported cases enforced by the Infectious Diseases Control Law from January 1, 2013 to December 31, 2014.Results The public health center questioned hospitals/clinics and (nursery) schools about all registered measles or rubella cases in (N)SASSy on the same day to check the entered information. In the past 2 years, there were 5 measles and 56 rubella cases in 2013 and 1 measles and 19 rubella cases in 2014 registered with (N)SASSy. All cases were checked and investigated by the public health center. Of all cases detected by (N)SASSy, 7 rubella cases in 2013 and 1 rubella case in 2014 were reported based on the law. No measles cases were reported in the 2 years. The results of investigations and laboratory tests were given as feedback to the (nursery) schools. If the case did not case definition determined by the law, we changed the status in (N)SASSy to suspected or discarded cases.Conclusion Since (N)SASSy assists prefectural government officers with earlier detection of and response for infectious diseases, it definitely contributes to infection control

  15. Bilateral megalocystic ovaries following in vitro fertilization detected during cesarean section: a case presentation.

    Science.gov (United States)

    Alptekin, Hüsnü; Gezginç, Kazım; Yılmaz, Fatma Yazıcı

    2012-01-01

    We present a patient with persistent bilateral megalocystic ovaries following in vitro fertilization which was detected during cesarean section. A 24 year-old primigravida presented to our clinic at the 36(th) week of a twin pregnancy with labour pain and cervical dilatation. On ultrasound examination, 2 masses of 90×60 and 60×70 mm were seen in the right and left adnexal regions respectively. Her history showed that she had unexplained infertility for 4 years and had undergone IVF with gonadotropin releasing hormone (GnRH)-agonist stimulation. Two embryos were transferred. Twin pregnancy was detected on ultrasound examination. The patient was delivered by emergency caesarean section due to transverse presentations at 36(th) weeks of gestation. During the operation, both adnexae were markedly enlarged, the right ovary measuring about 15×18 cm and the left about 16×18 cm. There was minimal ascites in the abdominal cavity. Ovarian biopsy was performed and the final pathology report showed bilateral follicle cysts. The patient was discharged on the postoperative 4(th) day. The patient was seen 4 weeks later. She had no complaints and ultrasound follow-up revealed a normal size uterus and ovaries. We should keep in mind that hyperstimulated, enlarged ovaries and its complication may be seen in the late weeks of pregnancy, even at term, in cases of in vitro fertilization cases. Therefore, close follow-up of pregnant IVF patints is recommended whether they had OHSS or not, because ovarian torsion caused by hyperstimulated ovaries may be difficult to diagnose during pregnancy. PMID:24592025

  16. Indoor terrestrial gamma dose rate mapping in France: a case study using two different geostatistical models

    International Nuclear Information System (INIS)

    Terrestrial gamma dose rates show important spatial variations in France. Previous studies resulted in maps of arithmetic means of indoor terrestrial gamma dose rates by “departement” (French district). However, numerous areas could not be characterized due to the lack of data. The aim of our work was to obtain more precise estimates of the spatial variability of indoor terrestrial gamma dose rates in France by using a more recent and complete data base and geostatistics. The study was based on the exploitation of 97 595 measurements results distributed in 17 404 locations covering all of France. Measurements were done by the Institute for Radioprotection and Nuclear Safety (IRSN) using RPL (Radio Photo Luminescent) dosimeters, exposed during several months between years 2011 and 2012 in French dentist surgeries and veterinary clinics. The data used came from dosimeters which were not exposed to anthropic sources. After removing the cosmic rays contribution in order to study only the telluric gamma radiation, it was decided to work with the arithmetic means of the time-series measurements, weighted by the time-exposure of the dosimeters, for each location. The values varied between 13 and 349 nSv/h, with an arithmetic mean of 76 nSv/h. The observed statistical distribution of the gamma dose rates was skewed to the right. Firstly, ordinary kriging was performed in order to predict the gamma dose rate on cells of 1*1 km2, all over the domain. The second step of the study was to use an auxiliary variable in estimates. The IRSN achieved in 2010 a classification of the French geological formations, characterizing their uranium potential on the bases of geology and local measurement results of rocks uranium content. This information is georeferenced in a map at the scale 1:1 000 000. The geological uranium potential (GUP) was classified in 5 qualitative categories. As telluric gamma rays mostly come from the progenies of the 238Uranium series present in rocks, this

  17. Dose rate calculations inside the containment shell of a PWR in case of an accident

    International Nuclear Information System (INIS)

    The aim of the study is the evaluation of γ dose rates. In view to treat the different aspects of partial or total melting of the reactor core, leading to emission of a great quantity of fission radioactive products in the containement shell, implying the loss of integrity of the first two containement barriers, the study comprises: 1) Calculation of the γ dose rate as a function of time, normalized in considering a total release of fission products present in the core at the moment of the accident: it is done by taking into account the fission products in suspension in the containement shell, deposited on the internal surfaces and trapped by the water drain. 2) Transfer hypotheses of fission products (the release kinematics are linked to the accident scenario). The hypotheses of emission and deposit in this work are those of Rasmussen

  18. What does measure the scaling exponent of the correlation sum in the case of human heart rate?

    Science.gov (United States)

    Säkki, M.; Kalda, J.; Vainu, M.; Laan, M.

    2004-03-01

    It is shown that in the case of human heart rate, the scaling behavior of the correlation sum (calculated by the Grassberger-Procaccia algorithm) is a result of the interplay of various factors: finite resolution of the apparatus (finite-size effects), a wide dynamic range of mean heart rate, the amplitude of short-time variability being a decreasing function of the mean heart rate. This is done via constructing a simple model of heart rhythm: a signal with functionally modulated Gaussian noise. This model reproduces the scaling behavior of the correlation sum of real medical data. The value of the scaling exponent depends on all the above-mentioned factors, and is a certain measure of short-time variability of the signal.

  19. Nocturnal hypoxia and the success rate of standard atrial fibrillation treatment: a case report

    OpenAIRE

    Güçyetmez, Bülent; Atalan, Hakan Korkut; Aloglu, Hikmet; Kelebek, Adnan; Açıl, Tayfun

    2015-01-01

    Introduction Sleep apnea-hypopnea syndrome (SAHS) is one of the extracardiac reasons of atrial fibrillation (AF), and the prevalence of AF is high in SAHS-diagnosed patients. Nocturnal hypoxemia is associated with AF, pulmonary hypertension, and nocturnal death. The rate of AF recurrence is high in untreated SAHS-diagnosed patients after cardioversion (CV). In this study, we present a patient whose SAHS was diagnosed with an apnea test performed in the intensive care unit (ICU) and who did no...

  20. Determinants of exchange rate volatility: the case of the new EU members

    Czech Academy of Sciences Publication Activity Database

    Stančík, Juraj

    2007-01-01

    Roč. 57, 9-10 (2007), s. 414-432. ISSN 0015-1920 R&D Projects: GA MŠk LC542 Grant ostatní: GA ČR(CZ) GA402/06/1293 Institutional research plan: CEZ:AV0Z70850503 Keywords : exchange - rate volatility * TARCH model * EMU integration Subject RIV: AH - Economics Impact factor: 0.382, year: 2007 http://journal.fsv.cuni.cz/storage/1085_fau_9_10_2007_00000002.pdf

  1. Determinants of exchange rate volatility: the case of the new EU members

    Czech Academy of Sciences Publication Activity Database

    Stančík, Juraj

    2007-01-01

    Roč. 57, 9-10 (2007), s. 414-432. ISSN 0015-1920 R&D Projects: GA ČR GA402/06/1293; GA MŠk LC542 Institutional research plan: CEZ:MSM0021620846 Keywords : exchange - rate volatility * TARCH model * EMU integration Subject RIV: AH - Economics Impact factor: 0.382, year: 2007 http://journal.fsv.cuni.cz/storage/1085_fau_9_10_2007_00000002.pdf

  2. Rate of Return to Investment in Education: A Case Study of Faisalabad

    OpenAIRE

    Zahoor Hussain Javed; Nafeesa Arshad

    2013-01-01

    The main aim of this research was to obtain rate of return to investment in education which is based on human capital Theory. This study seeks to find association between experience, education and earnings of university teacher. Therefore, this study is based on primary data which was collected from selected universities of Faisalabad. By using OLS techniques, this study analyzes the data and explores and concludes that experience and raising level of education put positive impact on earnings...

  3. Intervention Policy under Floating Exchange Rates: An Analysis of the Swiss Case.

    OpenAIRE

    Gartner, Manfred

    1987-01-01

    Empirical analyses of central bank foreign-exchange market intervention are typically cast in terms of a dichotomy between "leaning against the wind" and "exchange-rate targeting." Apparently, the profession has arrived at an almost unanimous verdict in favor of the former. Th is paper challenges the ruling consensus. Econometric estimates are c omputed on the basis of a more flexible intervention response functio n and a new proposal for removing simultaneous-equations bias in the context of...

  4. Economic Growth, Financial Depth and Lending Rate Nexus: A Case of Oil Dependant Economy

    OpenAIRE

    Najeeb Muhammad Nasir; Nasir Ali; Imran Khokhar

    2014-01-01

    This research empirically investigates the long and short run causal relationships between economic growth, financial depth and lending rate in the unique economic setup of Saudi Arabia where 92% of total GDP comes from oil exports. Study uses two proxies for financial depth namely liquid liability indicator and banks claim to the private sector to GDP ratio, while economic growth is measured by real GDP per capita. This study intends to get answers for such questions as, if financial depth e...

  5. Heart rate variability in sciatica patients referred to spine surgery: a case control study

    OpenAIRE

    Södervall, Jarmo; Karppinen, Jaro; Puolitaival, Jukka; Kyllönen, Eero; Kiviniemi, Antti M.; Tulppo, Mikko P.; Hautala, Arto J.

    2013-01-01

    Background A chronic pain condition may result in altered autonomic nervous system regulation in various patient populations. We evaluated whether autonomic regulation differs between sciatica patients referred to spine surgery and age-matched healthy controls analyzed with heart rate variability techniques (HRV). Methods HRV of patients (n = 201) and healthy controls (n = 138) were measured in standing conditions (5 min). High frequency (HF) power as an index of cardiac vagal modulation and ...

  6. Two Coupled Queues with Vastly Different Arrival Rates: Critical Loading Case

    Directory of Open Access Journals (Sweden)

    Charles Knessl

    2011-01-01

    Full Text Available We consider two coupled queues with a generalized processor sharing service discipline. The second queue has a much smaller Poisson arrival rate than the first queue, while the customer service times are of comparable magnitude. The processor sharing server devotes most of its resources to the first queue, except when it is empty. The fraction of resources devoted to the second queue is small, of the same order as the ratio of the arrival rates. We assume that the primary queue is heavily loaded and that the secondary queue is critically loaded. If we let the small arrival rate to the secondary queue be O(ε, where 0≤ε≪1, then in this asymptotic limit the number of customers in the first queue will be large, of order O(ε-1, while that in the second queue will be somewhat smaller, of order O(ε-1/2. We obtain a two-dimensional diffusion approximation for this model and explicitly solve for the joint steady state probability distribution of the numbers of customers in the two queues. This work complements that in (Morrison, 2010, which the second queue was assumed to be heavily or lightly loaded, leading to mean queue lengths that were O(ε-1 or O(1, respectively.

  7. Impact of updraft on neutralized charge rate by lightning in thunderstorms: A simulation case study

    Science.gov (United States)

    Wang, Fei; Zhang, Yijun; Zheng, Dong

    2015-12-01

    The rate of neutralized charge by lightning (RNCL) is an important parameter indicating the intensity of lightning activity. The total charging rate (CR), the CR of one kind of polarity (e.g., negative) charge (CROP), and the outflow rate of charge on precipitation (ORCP) are proposed as key factors impacting RNCL, based on the principle of conservation of one kind of polarity charge in a thunderstorm. In this paper, the impacts of updraft on CR and CROP are analyzed by using a 3D cloud resolution model for a strong storm that occurred in Beijing on 6 september 2008. The results show that updraft both promotes and inhibits RNCL at the same time. (1) Updraft always has a positive influence on CR. The correlation coefficient between the updraft volume and CR can reach 0.96. Strengthening of the updraft facilitates strengthening of RNCL through this positive influence. (2) Strengthening of the updraft also promotes reinforcement of CROP. The correlation coefficient between the updraft volume and CROP is high (about 0.9), but this promotion restrains the strengthening of RNCL because the strengthening of CROP will, most of the time, inhibit the increasing of RNCL. (3) Additionally, increasing of ORCP depresses the strengthening of RNCL. In terms of magnitude, the peak of ORCP is equal to the peak of CR. Because precipitation mainly appears after the lightning activity finishes, the depression effect of ORCP on RNCL can be ignored during the active lightning period.

  8. Change Detection Based on Persistent Scatterer Interferometry - Case Study of Monitoring AN Urban Area

    Science.gov (United States)

    Yang, C. H.; Soergel, U.

    2015-08-01

    Persistent Scatterer Interferometry (PSI) is a technique to extract subtle surface deformation from sets of scatterers identified in time-series of SAR images which feature temporally stable and strong radar signal (i.e., Persistent Scatterers, PS). Because of the preferred rectangular and regular structure of man-made objects, PSI works particularly well for monitoring of settlements. Usually, in PSI it is assumed that except for surface motion the scene is steady. In case this is not given, corresponding PS candidates are discarded during PSI processing. On the other hand, pixel-based change detection relying on local comparison of multi-temporal images typically highlights scene modifications of larger size rather than detail level. In this paper, we propose a method to combine these two types of change detection approaches. First, we introduce a local change-index based on PSI, which basically looks for PS candidates that remain stable over a certain period of time, but then break down suddenly. In addition, for the remaining PS candidates we apply common PSI processing which yields attributes like velocity in line-of-sight. In order to consider context, we apply now spatial filtering according to the derived attributes and morphology to exclude outliers and extract connect components of similar regions at the same time. We demonstrate our approach for test site Berlin, Germany, where, firstly, deformation-velocities on man-made structures are estimated and, secondly, some construction-sites are correctly recognized.

  9. Survey of prenatal screening policies in Europe for structural malformations and chromosome anomalies, and their impact on detection and termination rates for neural tube defects and Down's syndrome

    DEFF Research Database (Denmark)

    Boyd, P A; Devigan, C; Khoshnood, B;

    2008-01-01

    screening policies in 18 countries and 1.13 million births in 12 countries in 2002-04. METHODS: (i) Questionnaire on national screening policies and termination of pregnancy for fetal anomaly (TOPFA) laws in 2004. (ii) Analysis of data on prenatal detection and termination for Down's syndrome and neural...... tube defects (NTDs) using the EUROCAT database. MAIN OUTCOME MEASURES: Existence of national prenatal screening policies, legal gestation limit for TOPFA, prenatal detection and termination rates for Down's syndrome and NTD. RESULTS: Ten of the 18 countries had a national country-wide policy for Down...... associated with wide country variation in prenatal detection rates for Down's syndrome and NTD....

  10. Soil and phosphorus accretion rates in sub-tropical wetlands: Everglades Stormwater Treatment Areas as a case example.

    Science.gov (United States)

    Bhomia, R K; Inglett, P W; Reddy, K R

    2015-11-15

    Wetlands are known to serve as sinks for particulate matter and associated nutrients and contaminants. Consequently rate of soil accretion is critical for continued performance of wetlands to provide ecosystem services including water quality improvement and reduce excess contaminant loads into downstream waters. Here we demonstrate a new technique to determine rate of soil accretion in selected subtropical treatment wetlands located in southern USA. We also report changes in soil accretion rates and subsequent phosphorus (P) removal efficiency with increasing operational history of these treatment wetlands. Utilizing discernible signatures preserved within the soil depth profiles, 'change points' (CP) that corresponded to specific events in the life history of a wetland were determined. The CP was observed as an abrupt transition in the physico-chemical properties of soil as a manifestation of prevailing historical conditions (e.g. startup of treatment wetlands in this case). Vertical depth of CP from the soil surface was equivalent to the depth of recently accreted soil (RAS) and used for soil accretion rate calculations. Annual soil and P accretion rates determined using CP technique (CPT) in studied wetlands ranged from 1.0±0.3 to 1.7±0.8 cm yr(-1) and 1.3±0.6 to 3.3±2 g m(-2) yr(-1), respectively. There was no difference in RAS depth between emergent and submerged aquatic vegetation communities found at the study location. Our results showed that soil and P accretion rates leveled off after 10 yr of treatment wetlands' operation. On comparison, soil accretion rates and RAS depth determined by CPT were commensurate with that measured by other techniques. CPT can be easily used where a reliable record of wetland establishment date or some significant alteration/perturbation is available. This technique offers a relatively simple alternative to determine vertical accretion rates in free-water surface wetlands. PMID:26172597

  11. [The determinants of the low case fatality rate of the cholera epidemic in the Littoral department of Benin in 2008].

    Science.gov (United States)

    Gbary, Akpa Raphaël; Sossou, Roch Aristide; Dossou, Jean-Paul; Mongbo, Virginie; Massougbodji, Achille

    2011-01-01

    The 2008 cholera outbreak in Benin was characterized by a low case fatality rate (0.39 p.100) in the Littoral department, where 502 cases were recorded between July and December. The aim of this study was to identify the key factors associated with the low case fatality rate within the department. The cross-sectional, descriptive and analytical study conducted as part of this research used 404 patient records, focus group discussions with ten former patients, in-depth interviews with 8 health authorities involved in the response and structured face-to-face interviews with 12 health personnel involved in the treatment of patients. The data were analyzed using qualitative and quantitative content analysis based on EPIINFO 3.3.2 and EXCEL 2007 software. The results from several sources were cross-checked through triangulation. The mean age of patients was 23.72 ± 14.8 years. 39.35% patients were admitted with severe dehydration. Oral rehydration, intravenous rehydration and antibiotic therapy were given to 99.5%, 85% and 97.77% of patients, respectively. Only one hospital death was noted. The low case fatality rate was mainly due to the following factors: the high quality of care provided in a center with qualified personnel and available and free of charge treatment kits, protocols based on massive rehydration and appropriate hygiene measures, and patient compliance with the treatment plan. The response was also characterized by good coordination, wide mass and local health promotion, and selective antibiotic prophylaxis, which contributed significantly to reducing the spread of the infection. PMID:22177702

  12. Rate of Pressure Ulcers in Intensive Units and General Wards of Iranian Hospitals and Methods for Their Detection.

    Directory of Open Access Journals (Sweden)

    Ali Akbari Sari

    2014-06-01

    Full Text Available This study aimed to estimate the rate of pressure ulcers in intensive care units (ICUs and medical and surgical wards of Iranian hospitals and compare the performance of methods of medical record review as well as direct observation for their detection.The research team visited 308 patients in medical and surgical wards of hospitals affiliated with Tehran University of Medical Sciences and a further 90 patients in their ICUs between March 2009 and April 2010. In addition 310 patient records were randomly selected from patients discharged from the ICUs between March 2009 and April 2010. And a further 600 patient records were randomly selected from the patients that were discharged from medical and surgical wards between March 2010 and April 2011. These 910 selected records were retrospectively reviewed to identify pressure ulcers. Data were collected by a structured checklist.In ICUs 24 of 90 patients (26.7%, 95% CI: 17.56 to 35.84 that were directly observed and 59 of 310 patients (19.0%, 95% CI: 14.63 to 23.37 that were studied by retrospective review of medical records had pressure ulcers. In medical and surgical wards, 5 of 308 patients (1.6%, 95% CI: 0.20 to 3.00 that were directly observed had pressure ulcers, but no pressure ulcer was detected by review of 600 medical records.Pressure ulcers are significantly more frequent in ICUs than in medical and surgical wards and a significant proportion of pressure ulcers are not reported.

  13. The Fed and the new monetary consensus: The Case for Rate Hikes, Part Two

    OpenAIRE

    Wray , L. Randall

    2004-01-01

    From this paper's Preface, by Dr. Dimitri B. Papadimitriou, President: In Public Policy Brief No. 79, L. Randall Wray wrote about the Federal Reserve’s recent interest rate hikes that "the most charitable interpretation of the Fed’s policy change is that it appears to be premature."Wray marshaled a convincing array of data on payrolls, employment-to-population ratios, and other labor market indicators to show "that the current recovery has not yet attained the degree of labor market tightness...

  14. Simplifying consent for HIV testing is associated with an increase in HIV testing and case detection in highest risk groups, San Francisco January 2003-June 2007.

    Directory of Open Access Journals (Sweden)

    Nicola M Zetola

    Full Text Available BACKGROUND: Populations at highest risk for HIV infection face multiple barriers to HIV testing. To facilitate HIV testing procedures, the San Francisco General Hospital Medical Center eliminated required written patient consent for HIV testing in its medical settings in May 2006. To describe the change in HIV testing rates in different hospital settings and populations after the change in HIV testing policy in the SFDH medical center, we performed an observational study using interrupted time series analysis. METHODS: Data from all patients aged 18 years and older seen from January 2003 through June 2007 at the San Francisco Department of Public Health (SFDPH medical care system were included in the analysis. The monthly HIV testing rate per 1000 had patient-visits was calculated for the overall population and stratified by hospital setting, age, sex, race/ethnicity, homelessness status, insurance status and primary language. RESULTS: By June 2007, the average monthly rate of HIV tests per 1000 patient-visits increased 4.38 (CI, 2.17-6.60, p<0.001 over the number predicted if the policy change had not occurred (representing a 44% increase. The monthly average number of new positive HIV tests increased from 8.9 (CI, 6.3-11.5 to 14.9 (CI, 10.6-19.2, p<0.001, representing a 67% increase. Although increases in HIV testing were seen in all populations, populations at highest risk for HIV infection, particularly men, the homeless, and the uninsured experienced the highest increases in monthly HIV testing rates after the policy change. CONCLUSIONS: The elimination of the requirement for written consent in May 2006 was associated with a significant and sustained increase in HIV testing rates and HIV case detection in the SFDPH medical center. Populations facing the higher barriers to HIV testing had the highest increases in HIV testing rates and case detection in response to the policy change.

  15. Monitoring land subsidence rates with permanent scatterers SAR interferometry: a case study of Beijing, China

    Science.gov (United States)

    Fan, Jun; Li, Xiaojuan; Yu, Jie; Wang, Yanbing; Wan, Yanyan; An, Zhihui

    2015-12-01

    The ground subsidence phenomenon is more serious in Beijing, large-scale land subsidence seriously threats to urban planning and construction and the safety of residents. In order to study the subsidence condition, it is necessary to monitor land subsidence. Choosing 28 scenes Envisat ASAR images covering Beijing city from December 2003 to March 2009, permanent scatterer SAR interferometry (PSI) technique was applied to obtained time series land subsidence information. Then the trend characteristics and factors of subsidence were analyzed, comparing land subsidence result with the groundwater data and geological structure data. Comparison between the PSI-derived subsidence rates and leveling data obtained shows that the result of PSI is agreed with the leveling data. The results indicate that the PSI technique is capable of providing high-level accuracy subsidence information. The results show that:(1) The deformation rates derived PSI ranging from -45.80 to 4.36mm/a;(2) In the study area, the serious subsidence areas distribute in Chaoyang District, Shunyi District, Tongzhou District and Pinggu District;(3) The subsidence tends to become more and more concentrated in 6 years from 2003 to 2009.

  16. Inner conflict between nuclear power generation and electricity rates: A Japanese case study

    International Nuclear Information System (INIS)

    Since the March 11 earthquake, Japanese households have been facing a trade-off problem between decreasing dependency on nuclear power generation and avoiding an increase in electricity rates. We analyze this inner conflict quantitatively, adopting two economic–psychological approaches: First, we note that the trade-off causes cognitive dissonance after making a choice that results in a wider desirability gap between the chosen and rejected alternatives. Second, the consumer surplus improves by 11.2% with a no-choice option for suspending judgment in the presence of cognitive dissonance. Third, individual characteristics such as gender and annual household income are significantly correlated with both cognitive dissonance and a preference for the no-choice option. - Highlights: • The Fukushima crisis shocked Japanese citizens' attitudes on nuclear power plants. • Citizens' attitudes toward nuclear power generation and electricity rates surveyed • The trade-off caused cognitive dissonance resulting in a hardline stance. • The consumer surplus improves with a no-choice option for suspending judgment

  17. Gold Price, Stock Price and Exchange rate Nexus: The Case of India

    Directory of Open Access Journals (Sweden)

    Srinivasan P

    2014-06-01

    Full Text Available The paper investigates the causal nexus between gold price, stock price and exchange rate in India through the Autoregressive Distributed Lag (ARDL bounds testing approach and Granger Causality test. Using monthly time series data, the empirical analysis is carried out for the period from June 1990 to April 2014. Our analysis reveals that gold price and stock price tend to have long-run relationship with exchange rate in India. Besides, there is no evidence of stable long-run cointegration relationship among stock price and gold price in India. Our empirical findings also indicate that there exists no causality runs from gold price to stock price or vice versa in the short-run. It can be concluded that domestic gold price does not contain any significant information to forecast stock prices in India. The study findings are consistent with Kaliyamoorthy and Parithi (2012 where they found no evidence of causality between the gold price and stock price in India.

  18. Automatic detection of a prefrontal cortical response to emotionally rated music using multi-channel near-infrared spectroscopy

    Science.gov (United States)

    Moghimi, Saba; Kushki, Azadeh; Power, Sarah; Guerguerian, Anne Marie; Chau, Tom

    2012-04-01

    Emotional responses can be induced by external sensory stimuli. For severely disabled nonverbal individuals who have no means of communication, the decoding of emotion may offer insight into an individual’s state of mind and his/her response to events taking place in the surrounding environment. Near-infrared spectroscopy (NIRS) provides an opportunity for bed-side monitoring of emotions via measurement of hemodynamic activity in the prefrontal cortex, a brain region known to be involved in emotion processing. In this paper, prefrontal cortex activity of ten able-bodied participants was monitored using NIRS as they listened to 78 music excerpts with different emotional content and a control acoustic stimuli consisting of the Brown noise. The participants rated their emotional state after listening to each excerpt along the dimensions of valence (positive versus negative) and arousal (intense versus neutral). These ratings were used to label the NIRS trial data. Using a linear discriminant analysis-based classifier and a two-dimensional time-domain feature set, trials with positive and negative emotions were discriminated with an average accuracy of 71.94% ± 8.19%. Trials with audible Brown noise representing a neutral response were differentiated from high arousal trials with an average accuracy of 71.93% ± 9.09% using a two-dimensional feature set. In nine out of the ten participants, response to the neutral Brown noise was differentiated from high arousal trials with accuracies exceeding chance level, and positive versus negative emotional differentiation accuracies exceeded the chance level in seven out of the ten participants. These results illustrate that NIRS recordings of the prefrontal cortex during presentation of music with emotional content can be automatically decoded in terms of both valence and arousal encouraging future investigation of NIRS-based emotion detection in individuals with severe disabilities.

  19. The Relationship between Shadow Economy and Unemployment Rate. A Ardl Causality Analysis for the Case Of Romania

    Directory of Open Access Journals (Sweden)

    Adriana AnaMaria DAVIDESCU

    2015-12-01

    Full Text Available The paper aims to investigate the nature of the relationship between the shadow economy (SE and unemployment rates (both registered and ILO for the case of Romania using Pesaran et al.(2001 bounds tests approach for cointegration. The study uses quarterly data covering the period 2000-2010. The size of Romanian shadow economy is estimated using the currency demand approach based on VECM models, stating that its size is decreasing over the analyzed period, from 36.5% at the end of 2000 to about 31.5% of real GDP at the middle of 2010. To investigate the long-run causal linkages and short-run dynamics between shadow economy and unemployment rate, ARDL cointegration approach is applied. Cointegration test results shows that in short-run both ILO and registered unemployment rate has a negative and statistically significant effect on the size of the shadow economy, while in the long-run the unemployment rates have a positive effect on shadow economy. The ARDL causality results revealed the existence of a long-run unidirectional causality that runs from unemployment rates (registered or ILO to shadow economy. In addition, the CUSUM and CUSUMSQ tests confirm the stability of the both causal relationships.

  20. On the sensitivity of extrasolar mass-loss rate ranges: HD 209458b a case study

    CERN Document Server

    D'Angelo, C S Villarreal; Costa, A; Velázquez, P; Raga, A; Esquivel, A

    2013-01-01

    We present a 3D hydrodynamic study of the effects that different stellar wind conditions and planetary wind structures have on the calculated Ly-$\\alpha$ absorptions produced during the transit of HD 209458b. Considering a range of stellar wind speeds $\\sim$[350-800] km s$^{-1}$, coronal temperature $\\sim$[3-7] $\\times10^{6}$ K and two values of the polytropic index $\\Gamma$ $\\sim$[1.01-1.13], while keeping fixed the stellar mass loss rate, we found a that a $\\dot M_p$ range between $\\sim$[3-5] $\\times 10^{10}$g s$^{-1}$ give account for the observational absorption in Ly-$\\alpha$ measured for the planetary system. Also, several models with anisotropic evaporation profiles for the planetary escaping atmosphere were carried out, showing that both, the escape through polar regions and through the night side yields larger absorptions than an isotropic planetary wind.

  1. Sustainability assessment of facilities - a comparative analysis of rating schemes Case VTT Digitalo

    Energy Technology Data Exchange (ETDEWEB)

    Airaksinen, M.; Huovila, P.; Nummelin, J.; Tuominen, P.

    2009-12-15

    The building sector contributes about a third of all energy-related emissions worldwide. Taking into account the emissions caused by land-use change impacts caused by urbanization, the manufacturing of building elements and the production of building materials, the share becomes even larger. According to the World Watch Institute, if the current trend continues the entire global community will run out of raw building materials by approximately 2030. Moreover, the building sector consumes water - a scarce resource in many parts of the world - for domestic use, landscapes and cooling towers. The building sector also generates a large variety of waste in construction, operation, renovation and, finally, demolition. Consequently, finding an effective way to transform the way we plan, design, build, operate, renovate and demolish buildings in the direction of sustainable practices has been the goal of many environmental assessment tools. In addition, there are co-benefits from this effort such as decreasing air and environmental pollution, improving health and productivity, and enabling sustainable economic development by promoting new sustainable technologies and behavior. Due to rising environmental concerns many local and global assessment tools have been developed. Because of the varying perspectives of the assessment tools the weighting factors applied to the various issues differ to some extent. The aim of this study was to understand the similarities and differences between various rating schemes currently applied in our market and to analyze their relation to LCA-based assessment and the new SBA system, which is still under development. The commercial rating tools studied were BREEAM, LEED and PromisE. (orig.)

  2. Molecular analysis using DHPLC of cystic fibrosis: increase of the mutation detection rate among the affected population in Central Italy

    Directory of Open Access Journals (Sweden)

    Nardone Anna

    2004-04-01

    Full Text Available Abstract Background Cystic fibrosis (CF is a multisystem disorder characterised by mutations of the CFTR gene, which encodes for an important component in the coordination of electrolyte movement across of epithelial cell membranes. Symptoms are pulmonary disease, pancreatic exocrine insufficiency, male infertility and elevated sweat concentrations. The CFTR gene has numerous mutations (>1000 and functionally important polymorphisms (>200. Early identification is important to provide appropriate therapeutic interventions, prognostic and genetic counselling and to ensure access to specialised medical services. However, molecular diagnosis by direct mutation screening has proved difficult in certain ethnic groups due to allelic heterogeneity and variable frequency of causative mutations. Methods We applied a gene scanning approach using DHPLC system for analysing specifically all CFTR exons and characterise sequence variations in a subgroup of CF Italian patients from the Lazio region (Central Italy characterised by an extensive allelic heterogeneity. Results We have identified a total of 36 different mutations representing 88% of the CF chromosomes. Among these are two novel CFTR mutations, including one missense (H199R and one microdeletion (4167delCTAAGCC. Conclusion Using this approach, we were able to increase our standard power rate of mutation detection of about 11% (77% vs. 88%.

  3. Bleeding rates necessary for detecting acute gastrointestinal bleeding with technetium-99m-labeled red blood cells in an experimental model

    International Nuclear Information System (INIS)

    Proponents of [/sup 99m/Tc]sulfur colloid for GI bleeding studies argue that, although labeled red blood cells are useful for intermittent bleeding, they are not capable of detecting low bleeding rates. Studies of dogs with experimental GI bleeding have indicated bleeding rates of 0.05 ml/min can be detected with [/sup 99m/Tc]sulfur colloid. Since similar data in the dog model were unavailable for /sup 99m/Tc-labeled red blood cells, we undertook this study. To simulate lower GI bleeding, catheters were inserted into the bowel lumen. Each dog's blood was labeled with /sup 99m/Tc using an in vitro technique. Venous blood was then withdrawn and re-infused into the lumen of the bowel using a Harvard pump. Fourteen dogs were studied, ten receiving a bleeding rate from 4.6-0.02 ml/min in the descending colon and four with proximal jejunal bleeds of 0.20-0.02 ml/min. Bleeding rates of 4.6-0.2 ml/min were detected within 10 min in the colon and bleeding rates as low as 0.04 ml/min were seen by 55 min. Slower bleeding rates were not detected. Similar findings were noted for proximal jejunal bleeds. Based on the time of appearance, a minimum volume of approximately 2-3 ml labeled blood was necessary to detect bleeding. We conclude that /sup 99m/Tc-labeled RBCs are sensitive for low bleeding rates in the dog model. The rates are comparable to those described for [/sup 99m/Tc]sulfur colloid in this experimental setting. The time of appearance of activity is related to the bleeding rate

  4. Artemisinin resistance containment project in Thailand. (I: Implementation of electronic-based malaria information system for early case detection and individual case management in provinces along the Thai-Cambodian border

    Directory of Open Access Journals (Sweden)

    Khamsiriwatchara Amnat

    2012-07-01

    Full Text Available Abstract Background The Bureau of Vector-borne Diseases, Ministry of Public Health, Thailand, has implemented an electronic Malaria Information System (eMIS as part of a strategy to contain artemisinin resistance. The attempt corresponds to the WHO initiative, funded by the Bill & Melinda Gates Foundation, to contain anti-malarial drug resistance in Southeast Asia. The main objective of this study was to demonstrate the eMIS’ functionality and outputs after implementation for use in the Thailand artemisinin-resistance containment project. Methods The eMIS had been functioning since 2009 in seven Thai-Cambodian border provinces. The eMIS has covered 61 malaria posts/clinics, 27 Vector-borne Disease Units covering 12,508 hamlets at risk of malaria infections. The eMIS was designed as an evidence-based and near real-time system to capture data for early case detection, intensive case investigation, monitoring drug compliance and on/off-site tracking of malarial patients, as well as collecting data indicating potential drug resistance among patients. Data captured by the eMIS in 2008–2011 were extracted and presented. Results The core functionalities of the eMIS have been utilized by malaria staff at all levels, from local operational units to ministerial management. The eMIS case detection module suggested decreasing trends during 2009–2011; the number of malaria cases detected in the project areas over the years studied were 3818, 2695, and 2566, with sero-positive rates of 1.24, 0.98, and 1.16%, respectively. The eMIS case investigation module revealed different trends in weekly Plasmodium falciparum case numbers, when classified by responsible operational unit, local and migrant status, and case-detection type. It was shown that most Thai patients were infected within their own residential district, while migrants were infected either at their working village or from across the border. The data mapped in the system suggested that P

  5. Detection Rates of Cortical Auditory Evoked Potentials at Different Sensation Levels in Infants with Sensory/Neural Hearing Loss and Auditory Neuropathy Spectrum Disorder.

    Science.gov (United States)

    Gardner-Berry, Kirsty; Chang, Hsiuwen; Ching, Teresa Y C; Hou, Sanna

    2016-02-01

    With the introduction of newborn hearing screening, infants are being diagnosed with hearing loss during the first few months of life. For infants with a sensory/neural hearing loss (SNHL), the audiogram can be estimated objectively using auditory brainstem response (ABR) testing and hearing aids prescribed accordingly. However, for infants with auditory neuropathy spectrum disorder (ANSD) due to the abnormal/absent ABR waveforms, alternative measures of auditory function are needed to assess the need for amplification and evaluate whether aided benefit has been achieved. Cortical auditory evoked potentials (CAEPs) are used to assess aided benefit in infants with hearing loss; however, there is insufficient information regarding the relationship between stimulus audibility and CAEP detection rates. It is also not clear whether CAEP detection rates differ between infants with SNHL and infants with ANSD. This study involved retrospective collection of CAEP, hearing threshold, and hearing aid gain data to investigate the relationship between stimulus audibility and CAEP detection rates. The results demonstrate that increases in stimulus audibility result in an increase in detection rate. For the same range of sensation levels, there was no difference in the detection rates between infants with SNHL and ANSD. PMID:27587922

  6. Shale gas technology innovation rate impact on economic Base Case – Scenario model benchmarks

    International Nuclear Information System (INIS)

    Highlights: • Cash flow models control which technology is affordable in emerging shale gas plays. • Impact of technology innovation on IRR can be as important as wellhead price hikes. • Cash flow models are useful for technology decisions that make shale gas plays economic. • The economic gap can be closed by appropriate technology innovation. - Abstract: Low gas wellhead prices in North America have put its shale gas industry under high competitive pressure. Rapid technology innovation can help companies to improve the economic performance of shale gas fields. Cash flow models are paramount for setting effective production and technology innovation targets to achieve positive returns on investment in all global shale gas plays. Future cash flow of a well (or cluster of wells) may either improve further or deteriorate, depending on: (1) the regional volatility in gas prices at the wellhead – which must pay for the gas resource extraction, and (2) the cost and effectiveness of the well technology used. Gas price is an externality and cannot be controlled by individual companies, but well technology cost can be reduced while improving production output. We assume two plausible scenarios for well technology innovation and model the return on investment while checking against sensitivity to gas price volatility. It appears well technology innovation – if paced fast enough – can fully redeem the negative impact of gas price decline on shale well profits, and the required rates are quantified in our sensitivity analysis

  7. Corrosion Rate of Hydrogenation to C110 Casing in High H2S Environment

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhi; LI Changjin; ZHANG Jiyin; SHI Taihe

    2012-01-01

    The corrosion behavior of C110 bushing at high temperature and high pressure with a high H2S / CO2 was studied,and a basis for the materials selection of sour gas well bushing was provided in H2S,CO2 and saline coexisting environment.Under acidic condiction,hydrogen atoms greatly entered into the material and caused the material properties changed.Weight loss method was used to study the corrosion rate of hydrogen charging samples and original untreated samples in simulated oil field environment.PAR2273 electrochemical workstation was used to examine the electrochemical performance of samples untreated,hydrogen charging after reacting in autoclave.The corrosion product film was observed through SEM.The experimental results show that sample with hydrogen charging has a much more obvious partial corrosion and pitting corrosion than the untreated blank sample even the downhole corrosion speed of bushing is increased after being used for a period of time.Polarization curve shows the corrosion tendency is the same between sample with or without hydrogen charging and corrosion tendency is reduced by corrosion product film.A layer of dense product film formed on the surface of samples provides a certain protective effect to the matrix,but cracked holes which will accelerate partial corrosion of the sample were also observed.

  8. Quantifying Knick Point Migration Rates Related to the Messinian Crisis. The Case of the Nile River

    Science.gov (United States)

    Stüwe, Kurt; Pucher, Christoph; Robl, Jörg; Hergarten, Stefan

    2016-04-01

    The Messinian crisis is a temporally well-constrained period between 5.3 my and 5.9 my, when the strait of Gibraltar was tectonically closed and the Mediterranean Sea had consequently desiccated. This dramatic base level drop by about 1500 vertical meters had a profound influence on the geomorphic evolution of the major drainages surrounding the Mediterranean basin. In particular, it caused substantial knickpoints in the major rivers including the Rhone, the Ebro, the Po and the Nile. While the knickpoints of the Rhone and Ebro have been studied previously and the knickpoints created by the Po may lie today underneath the Po plains, the knickpoint and its migration along the Nile has not been studied and would have migrated along its current river channel. In this contribution we focus on numerical modelling of the knickpoint migration in the Nile and use our modelling results in comparison with the present day morphological analyses of the river to constrain absolute migration rates. We suspect that the first Nile cataract near Assuan, some 1000 km upstream of today's river mouth may be the relict of the Messinian salinity crisis making it to one of the fastest migrating knickpoints in the world.

  9. Rapid detection of bacteria in drinking water and water contamination case studies

    Institute of Scientific and Technical Information of China (English)

    Rolf A. Deininger; Jiyoung Lee; Robert M. Clark

    2011-01-01

    Water systems are inherently vulnerable to physical,chemical and biologic threats that might compromise a systems' ability to reliably deliver safe water.The ability of a water supply to provide water to its customers can be compromised by destroying or disrupting key physical elements of the water system.However,contamination is generally viewed as the most serious potential terrorist threat to water systems.Chemical or biologic agents could spread throughout a distribution system and result in sickness or death among the consumers and for some agents the presence of the contaminant might not be known until.emergency rooms report an increase in patients with a particular set of symptoms.Even without serious health impacts,just the knowledge that a water system had been breached could seriously undermine consumer confidence in public water supplies.Therefore,the ability to rapidly detect contamination,especially microbiological contamination,is highly desirable.The authors summarize water contamination case studies and discuss a technique for identifying microbiological contamination based on ATP bioluminescence.This assay allows an estimation of bacterial populations within minutes and can be applied using a local platform.Previous ATP-based methods requires one hour,one liter of water,and has a sensitivity of 100000 cells for detection.The improved method discussed here is 100 times more sensitive,requires one-hundredth of the sample volume,and is over 10 times faster than standard method.This technique has a great deal of potential for application in situations in which a water system has been compromised.

  10. Use of uranium isotopes for the determination of river tributary flow rates. Case of the Var and the Vesubie

    International Nuclear Information System (INIS)

    When a river flow rate is known on one point, it is possible to determine the one of upstream tributaries. This can be done by measuring the concentrations of a dissolved element (for example Ca2+), provided that no chemical precipitations have occurred in mixture waters. In this later case, the determination of flow rate is however possible by isotopic geochemistry, by knowing isotopic ratios of an element, for ex. 234U/238U, in each river considered and the ratio of the concentrations in dissolved 238U in two of them. A study of the Var and its tributary the Vesubie is performed: in January 31st, 2001, the flow rate D3, downstream the confluence was 35 m3/s. The ratio of the 238U concentrations in the Vesubie river and in the Var upstream (238U1/238U2) was 5.5. The isotopic ratios 234U/238U measured in the Var, downstream the confluence were R3 = 1.51, upstream R2 = 1.75, and in the Vesubie R1 = 1.08. We have calculated the Vesubie flow rate as D1 = 3.2 m3/s. (author)

  11. Use of uranium isotopes for the determination of river tributary Flow rates : case of the var and the Vesubie

    International Nuclear Information System (INIS)

    When a river flow rate is known on one point, it is possible to determine the one of Upstream tributaries. This can be done by measuring the concentrations in a dissolved element (for ex.Ca2+), provided that no chemical precipitations has occurred in mixture waters. In this Later case, the determination of flow rate is however possible by isotopic geochemistry, knowing Isotopic ratios of a same element, for ex. 234U/238U, in each river considered and the ratio of the Concentrations in dissolved 238U in two of them. A study of the Var and its tributary the Vesubie is proposed: the January 31st, 2001, the Flow rate D3, downstream the confluence was 35m3/s. The ratio of the 238U concentrations in the Vesubie river and in the Var upstream (238U1/238U2) was 5.5. The isotopic ratios 234U/238U measured in the Var, downstream the confluence were R3 1.51, Upstream R2 = 1.75, and in the Vesubie R1 = 1.08. We have deduced by calculation the Vesubie Flow rate D1 = 3.2 m3/s

  12. Bladder perforation during laparoscopy detected by gaseous distention of the urinary bag -A report of two cases-

    OpenAIRE

    Woo, Jae Hee; Lee, Guie Yong; Baik, Hee Jung

    2011-01-01

    Bladder perforation during laparoscopy is a recognized, uncommon complication. We present two cases of bladder perforation during laparoscopic gynecologic operations that were detected by gaseous distention of the urinary bag. Bladder perforation occurred through laparoscopic division of adhesion. One bladder perforation was repaired laparoscopically, and the other case was repaired by laparotomy during the same general anesthesia. In this report, we present evidence that monitoring a gas-dis...

  13. Metodologia de rating em cooperativas agropecuárias: um estudo de caso Rating methodology in agricultural cooperatives: a case study

    Directory of Open Access Journals (Sweden)

    Davi Rogério de Moura Costa

    2009-12-01

    information asymmetry among cooperatives and the financial markets agents. In this way, developing a rating methodology applied to agricultural cooperatives in Brazil to reduce moral hazard and adverse selection that creates business and contractual organizational inefficiency among cooperatives and financial markets agents. The 'five C' method was used which considers organizational financial capacity, corporate governance characteristics, relations with members, and commodity market characteristics, among others. A weighting and evaluation were associated with each variable. The result was applied to an agricultural cooperative case study which concluded that this methodology is applicable and that results, evaluations and weights, could be discussed in cooperative rating committees. As a final consideration, an agenda is discussed for new applications of this methodology, for testing in other agricultural cooperative organizations and to consolidate it as a market financial information signal.

  14. A case of prenatally detected hepatic cyst communicating with the hepatic duct

    Directory of Open Access Journals (Sweden)

    Shinsuke Katsuno

    2014-10-01

    Full Text Available Here, we describe the case of a 9-year-old girl. During the patient's prenatal period, her mother had suffered domestic violence perpetrated by the patient's father. On maternal ultrasonography and magnetic resonance imaging, an intraabdominal cystic lesion was detected in the fetus at around the 30th prenatal week. The patient was delivered normally, and there were no evident anomalies on her body. Computed tomography with drip infusion cholangiography and percutaneous retrograde transhepatic cholangiography demonstrated an intrahepatic cyst of approximately 3 cm in diameter, which was located at S5–S8 and communicated with the confluence of the bilateral hepatic ducts. The cyst is clinically conjectured to be a solitary intrahepatic biliary cyst. However, it remains possible that the cyst is a ciliated hepatic foregut cyst or indicates hepatic injury that may have occurred as a result of domestic violence to the mother. Careful, long-term observation of the patient will be continued to ensure that any malignant transformation is not missed.

  15. Preliminary experiences with sentinel lymph node detection in cases of vulvar malignancy

    Energy Technology Data Exchange (ETDEWEB)

    Zambo, Katalin; Schmidt, Erzsebet; Dehghani, Babak [Department of Nuclear Medicine, University of Pecs, Faculty of Medicine (Hungary); Hartmann, Tamas; Bodis, Jozsef [Department of Obstetrics and Gynecology, County Teaching Hospital, University of Pecs, Faculty of Health Sciences (Hungary); Kornya, Laszlo [Department of Obstetrics and Gynecology, Peterfy Sandor Hospital, Budapest (Hungary); Tinneberg, Hans Rudolf [Department of Obstetrics and Gynecology, City Hospital Bielefeld (Germany)

    2002-09-01

    Lymph node status is the most important prognostic factor in vulvar malignancy. The aim of this pilot study was to explore the clinical significance of radionuclide lymphoscintigraphy in the management of vulvar neoplasms. Eight patients with squamous cell carcinoma and two patients with malignant melanoma of the vulva were studied with 100 MBq technetium-99m nanocolloid (Sentiscint, OSSKI, Budapest) 1 day before surgery. The location of the sentinel lymph node was checked by a single-head gamma camera-computer system (MB 9200, Mediso, Budapest). Vulvectomy with bilateral inguinofemoral lymphadenectomy was performed in each case. At lymphadenectomy, the sentinel lymph node was separately removed and histologically studied. Three of the ten patients had positive sentinel lymph nodes (micrometastasis). Five months later one of them had local recurrence of the vulvar cancer, and another had inguinal recurrence of the tumour 6 months postoperatively; the third patient was operated on only recently. Our preliminary results are impressive and suggest that lymphoscintigraphy is an easy and reliable method for detection of the sentinel lymph node in vulvar malignancy. (orig.)

  16. Detection of fast radio transients with multiple stations: a case study using the Very Long Baseline Array

    CERN Document Server

    Thompson, David R; Brisken, Walter; Deller, Adam T; Majid, Walid A; Tingay, Steven J; Wayth, Randall B

    2011-01-01

    Recent investigations reveal an important new class of transient radio phenomena that occur on sub-millisecond timescales. Often transient surveys' data volumes are too large to archive exhaustively. Instead, an on-line automatic system must excise impulsive interference and detect candidate events in real-time. This work presents a case study using data from multiple geographically distributed stations to perform simultaneous interference excision and transient detection. We present several algorithms that incorporate dedispersed data from multiple sites, and report experiments with a commensal real-time transient detection system on the Very Long Baseline Array (VLBA). We test the system using observations of pulsar B0329+54. The multiple-station algorithms enhanced sensitivity for detection of individual pulses. These strategies could improve detection performance for a future generation of geographically distributed arrays such as the Australian Square Kilometre Array Pathfinder and the Square Kilometre A...

  17. Effects of fixed time AI and AI at detected estrus on conception rate in smallholder zebu and crossbred heifers and cows subjected to double PGF2α administration.

    Science.gov (United States)

    Gugssa, Tadesse; Ashebir, Gebregiorgis; Yayneshet, Tesfay

    2016-08-01

    The study was conducted to evaluate estrus response, time to the onset of estrus, and conception rate at fixed time AI and AI at detected estrus in local and crossbred heifers and cows subjected to double administration of PGF2α. One hundred twenty local (heifers, n = 27; cows, n = 33) and crossbreds (heifers, n = 21; cows, n = 39) were used for the study. About 63 and 85.7 % of the local and crossbred heifers, respectively, exhibited estrus. Similarly, all crossbred cows and 90.9 % of local cows showed estrus. Most heifers came to estrus between 48 and 72 h while cows exhibited behavioral signs of estrus between 72 and 96 h. AI at detected estrus resulted in higher conception rate than fixed time AI. Pregnancy per artificial insemination was higher in AI at detected estrus than fixed time AI. Accurate estrus detection followed by insemination are crucial factors in maximizing pregnancy, and this study has demonstrated that conception rate in smallholder heifers and cows should be inseminated following estrus detection to maximize the conception rate of the animals. PMID:27184042

  18. Detection of "punctuated equilibrium" by bayesian estimation of speciation and extinction rates, ancestral character states, and rates of anagenetic and cladogenetic evolution on a molecular phylogeny.

    Science.gov (United States)

    Bokma, Folmer

    2008-11-01

    Algorithms are presented to simultaneously estimate probabilities of speciation and extinction, rates of anagenetic and cladogenetic phenotypic evolution, as well as ancestral character states, from a complete ultrametric species-level phylogeny with dates assigned to all bifurcations and one or more phenotypes in three or more extant species, using Metropolis-Hastings Markov Chain Monte Carlo sampling. The algorithms also estimate missing phenotypes of extant species and numbers of speciation events that occurred on all branches of the phylogeny. The algorithms are discussed and their performance is evaluated using simulated data. That evaluation shows that precise estimation of rates of evolution of one or a few phenotypes requires large phylogenies. Estimation accuracy improves with the number of species on the phylogeny. PMID:18752617

  19. Legionnaires’ disease case-finding algorithm, attack rates, and risk factors during a residential outbreak among older adults: an environmental and cohort study

    Science.gov (United States)

    2013-01-01

    Background During a Legionnaires’ disease (LD) outbreak, combined epidemiological and environmental investigations were conducted to identify prevention recommendations for facilities where elderly residents live independently but have an increased risk of legionellosis. Methods Survey responses (n = 143) were used to calculate attack rates and describe transmission routes by estimating relative risk (RR) and 95% confidence intervals (95% CI). Potable water collected from five apartments of LD patients and three randomly-selected apartments of residents without LD (n = 103 samples) was cultured for Legionella. Results Eight confirmed LD cases occurred among 171 residents (attack rate = 4.7%); two visitors also developed LD. One case was fatal. The average age of patients was 70 years (range: 62–77). LD risk was lower among residents who reported tub bathing instead of showering (RR = 0.13, 95% CI: 0.02–1.09, P = 0.03). Two respiratory cultures were characterized as L. pneumophila serogroup 1, monoclonal antibody type Knoxville (1,2,3), sequence type 222. An indistinguishable strain was detected in 31 (74%) of 42 potable water samples. Conclusions Managers of elderly-housing facilities and local public health officials should consider developing a Legionella prevention plan. When Legionella colonization of potable water is detected in these facilities, remediation is indicated to protect residents at higher risk. If LD occurs among residents, exposure reduction, heightened awareness, and clinical surveillance activities should be coordinated among stakeholders. For prompt diagnosis and effective treatment, clinicians should recognize the increased risk and atypical presentation of LD in older adults. PMID:23806063

  20. Impact of diabetic retinopathy screening on a British district population: case detection and blindness prevention in an evidence- based model

    OpenAIRE

    Bachmann, M. O.; Nelson, S. J.

    1998-01-01

    OBJECTIVES: To quantify case detection and blindness prevention attainable through screening for diabetic retinopathy in a district population. DESIGN: Literature review including a pooled estimate of screening test sensitivity, and quantitative modelling, including sensitivity analyses. SETTING AND PATIENTS: The diabetic population of a typical district health authority or health board. MAIN RESULTS: Evidence suggests that in a British general practice based diabetic population, preval...

  1. A broad-application microchannel-plate detector system for advanced particle or photon detection tasks: large area imaging, precise multi-hit timing information and high detection rate

    International Nuclear Information System (INIS)

    New applications for single particle and photon detection in many fields require both large area imaging performance and precise time information on each detected particle. Moreover, a very high data acquisition rate is desirable for most applications and eventually the detection and imaging of more than one particle arriving within a microsecond is required. Commercial CCD systems lack the timing information whereas other electronic microchannel plate (MCP) read-out schemes usually suffer from a low acquisition rate and complicated and sometimes costly read-out electronics. We have designed and tested a complete imaging system consisting of an MCP position readout with helical wire delay-lines, single-unit amplifier box and PC-controlled time-to-digital converter (TDC) readout. The system is very flexible and can detect and analyse position and timing information at single particle rates beyond 1 MHz. Alternatively, multi-hit events can be collected and analysed at about 20 kHz rate. We discuss the advantages and applications of this technique and then focus on the detector's ability to detect and analyse multiple hits

  2. Effect of faecal occult blood positivity on detection rates and positive predictive value of CT colonography when screening for colorectal neoplasia

    International Nuclear Information System (INIS)

    Aim: To determine the detection rates and positive predictive value (PPV) of computed tomography (CT) colonography (CTC) according to the magnitude of faecal occult blood test (FOBt) positivity. Materials and methods: Anonymised data from individuals undergoing CTC after a positive FOBt in the English Bowel Cancer Screening Programme were analysed. The detection of colorectal cancer (CRC), advanced neoplasia, and ≥6mm polyps were stratified by the number of positive FOBt windows. The PPV was calculated by reference to subsequent endoscopy results. The influence of the FOBt result on detection rates was estimated with multilevel logistic regression. PPV, CRC stage, and location were compared across groups according to FOBt positivity. Results: Four thousand, six hundred and one individuals were included (mean =66.7 years, 54.2% men). Detection rates of CRC and advanced neoplasia increased with greater numbers of positive FOBt windows (odds ratio [OR] for CRC=1.41; 95% confidence interval [CI]: 1.31–1.52; OR for advanced neoplasia=1.17; 95%CI: 1.12–1.23; both p<0.0001). The PPV was significantly greater at higher FOBt levels (p=0.020). The number of positive FOBt windows had no significant effect on stage (p=0.30) or location (p=0.20) of confirmed CRC. Conclusions: The magnitude of FOBt positivity influences the PPV and detection rates when screening for colorectal neoplasia. CTC may be particularly useful for FOBt patients with few positive test windows. -- Highlights: •Detection rates at CTC increase with higher levels of fecal occult blood (FOB). •Positive predictive value of CTC increases with greater FOB positivity. •Stage and location of cancers are not affected by magnitude of FOB positivity. •CTC may be valuable for otherwise low-risk patients with small amounts of FOB

  3. Effect of PSR J0737-3039 on the DNS Merger Rate and Implications for GW Detection

    OpenAIRE

    Kim, Chunglee; Kalogera, Vicky; Lorimer, Duncan R.

    2006-01-01

    We present the current estimates of the Galactic merger rate of double-neutron-star (DNS) systems. Using a statistical analysis method, we calculate the probability distribution function (PDF) of the rate estimates, which allows us to assign confidence intervals to the rate estimates. We calculate the Galactic DNS merger rate based on the three known systems B1913+16, B1534+12, and J0737-3039. The discovery of J0737-3039 increases the estimated DNS merger rate by a factor ~6 than what is prev...

  4. Geomorphic analysis in areas of low-rate neotectonic deformation: South Epirus (Greece) as a case study

    Science.gov (United States)

    Ntokos, Dimitrios; Lykoudi, Evdoxia; Rondoyanni, Theodora

    2016-06-01

    River morphology and the distribution of river deposits reliably reflect the neotectonic activity of a region in relation to rock resistance and climatic changes. Geomorphic indices have been used to identify landscape evolution and active faults, particularly in areas of high-rate tectonic deformation. In areas of low-rate deformation, the influence of neotectonic activity on landscape evolution is less apparent, although it is important. The aim of this study is to examine the region of south Epirus (Greece), a region where the rates of active tectonic processes are low. Because rock resistance is low and the sediment supply is intense in this region, the fault surfaces are either not well preserved or they are covered. For the purposes of this paper, geomorphic analysis (including the drainage basin asymmetry factor, the basin hypsometric curve and integral, the valley floor width-to-height ratio, longitudinal river profiles, the stream-length gradient index normalized by the graded river gradient, and the mountain front sinuosity index) was used to evaluate neotectonic activity and to identify covered, potentially active faults. In places where fault surfaces could be observed, geological mapping and tectonic analysis were applied to determine the fault characteristics. The first result of this work is that important active or potentially active faults extend for a significant distance into the alluvial plains of south Epirus. In this case study, we considered that geomorphic indices constitute a valuable tool for identifying neotectonic activity in regions of low-rate deformation. Furthermore, geomorphic analysis reveals the location of covered fault structures, contributes to evaluating fault capability, and therefore to estimating seismotectonic hazard.

  5. MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases.

    Science.gov (United States)

    Harper, Lorna; Fumagalli, Giorgio G; Barkhof, Frederik; Scheltens, Philip; O'Brien, John T; Bouwman, Femke; Burton, Emma J; Rohrer, Jonathan D; Fox, Nick C; Ridgway, Gerard R; Schott, Jonathan M

    2016-04-01

    Accurately distinguishing between different degenerative dementias during life is challenging but increasingly important with the prospect of disease-modifying therapies. Molecular biomarkers of dementia pathology are becoming available, but are not widely used in clinical practice. Conversely, structural neuroimaging is recommended in the evaluation of cognitive impairment. Visual assessment remains the primary method of scan interpretation, but in the absence of a structured approach, diagnostically relevant information may be under-utilized. This definitive, multi-centre study uses post-mortem confirmed cases as the gold standard to: (i) assess the reliability of six visual rating scales; (ii) determine their associated pattern of atrophy; (iii) compare their diagnostic value with expert scan assessment; and (iv) assess the accuracy of a machine learning approach based on multiple rating scales to predict underlying pathology. The study includes T1-weighted images acquired in three European centres from 184 individuals with histopathologically confirmed dementia (101 patients with Alzheimer's disease, 28 patients with dementia with Lewy bodies, 55 patients with frontotemporal lobar degeneration), and scans from 73 healthy controls. Six visual rating scales (medial temporal, posterior, anterior temporal, orbito-frontal, anterior cingulate and fronto-insula) were applied to 257 scans (two raters), and to a subset of 80 scans (three raters). Six experts also provided a diagnosis based on unstructured assessment of the 80-scan subset. The reliability and time taken to apply each scale was evaluated. Voxel-based morphometry was used to explore the relationship between each rating scale and the pattern of grey matter volume loss. Additionally, the performance of each scale to predict dementia pathology both individually and in combination was evaluated using a support vector classifier, which was compared with expert scan assessment to estimate clinical value

  6. Spontaneous emphysematous osteomyelitis of spine detected by computed tomography: Report of two cases

    Directory of Open Access Journals (Sweden)

    Senthil Kumar Aiyappan

    2014-01-01

    Full Text Available We hereby report two cases of spontaneous emphysematous osteomyelitis of spine caused by gas forming organisms in diabetic patients, which were diagnosed using computed tomography (CT and magnetic resonance imaging with one case managed successfully. These cases highlight the role of CT in diagnosis of gas forming spinal infections, especially in diabetic patients. Early and aggressive management is required in those cases to avoid mortality.

  7. High rates of detection of Clade 2.3.4.4 Highly Pathogenic Avian Influenza H5 viruses in wild birds in the Pacific Northwest during the winter of 2014/2015

    Science.gov (United States)

    Ip, Hon S.; Dusek, Robert; Bodenstein, Barbara L.; Torchetti, Mia Kim; DeBruyn, Paul; Mansfield, Kristin G.; DeLiberto, Thomas; Sleeman, Jonathan M.

    2016-01-01

    In 2014, Clade 2.3.4.4 H5N8 highly pathogenic avian influenza (HPAI) viruses spread across the Republic of Korea and ultimately were reported in China, Japan, Russia and Europe. Mortality associated with a reassortant HPAI H5N2 virus was detected in poultry farms in Western Canada at the end of November. The same strain (with identical genetic structure) was then detected in free-living wild birds that had died prior to December 8 of unrelated causes in Whatcom County, Washington, USA in an area contiguous with the index Canadian location. A gyrfalcon (Falco rusticolus) that had hunted and fed on an American wigeon (Anas americana) on December 6 in the same area and died two days later, tested positive for the Eurasian origin HPAI H5N8. Subsequently, an Active Surveillance Program using hunter-harvest waterfowl in Washington and Oregon detected ten HPAI H5 viruses, of three different subtypes (four H5N2, three H5N8 and three H5N1) with 4 segments in common (HA, PB2, NP and MA). In addition, a mortality-based Passive Surveillance Program detected 18 HPAI (14 H5N2 and four H5N8) cases from Idaho, Kansas, Oregon, Minnesota, Montana, Washington and Wisconsin. Comparatively, mortality-based passive surveillance appears to be detecting these HPAI infections at a higher rate than active surveillance during the period following initial introduction into the US.

  8. The use of saliva as a practical and feasible alternative to urine in large-scale screening for congenital cytomegalovirus infection increasesinclusion and detection rates

    Directory of Open Access Journals (Sweden)

    Emanuelle Santos de Carvalho Cardoso

    2015-04-01

    Full Text Available INTRODUCTION: Although urine is considered the gold-standard material for the detection of congenital cytomegalovirus (CMV infection, it can be difficult to obtain in newborns. The aim of this study was to compare the efficiency of detection of congenital CMV infection in saliva and urine samples. METHODS: One thousand newborns were included in the study. Congenital cytomegalovirus deoxyribonucleic acid (DNA was detected by polymerase chain reaction (PCR. RESULTS: Saliva samples were obtained from all the newborns, whereas urine collection was successful in only 333 cases. There was no statistically significant difference between the use of saliva alone or saliva and urine collected simultaneously for the detection of CMV infection. CONCLUSIONS: Saliva samples can be used in large-scale neonatal screening for CMV infection.

  9. Effect of PSR J0737-3039 on the DNS Merger Rate and Implications for GW Detection

    CERN Document Server

    Kim, C; Lorimer, D R; Kim, Chunglee; Kalogera, Vicky; Lorimer, Duncan R.

    2006-01-01

    We present the current estimates of the Galactic merger rate of double-neutron-star (DNS) systems. Using a statistical analysis method, we calculate the probability distribution function (PDF) of the rate estimates, which allows us to assign confidence intervals to the rate estimates. We calculate the Galactic DNS merger rate based on the three known systems B1913+16, B1534+12, and J0737-3039. The discovery of J0737-3039 increases the estimated DNS merger rate by a factor ~6 than what is previously known. The most likely values of DNS merger rate lie in the range 3-190 per Myr depending on different pulsar models. Motivated by a strong correlation between the peak rate estimates and a pulsar luminosity function, we calculate a 'global' probability distribution as a single representation of the parameter space covered by different pulsar population models. We compare the global PDF with the observed supernova Ib/c rate, which sets an upper limit on the DNS merger rate. Finally, we remark on implications of new...

  10. Detection of MYC gene rearrangements by conventional cytogenetics and fluorescent in situ hybridization in patients with acute lymphoblastic leukemia cases

    Directory of Open Access Journals (Sweden)

    Seda Eren

    2015-03-01

    Full Text Available Objective: The aim of this study is to investigate rearrangements at the region of MYC gene by conventional cytogenetics and interphase FISH methods in patients with acute lymphoblastic leukemia (ALL. Methods: The study was carried out on bone marrow specimens of 25 ALL patients who were referred to our laboratory. Fourteen children and 11 adult ALL cases were examined. Conventional cytogenetic analysis was performed using G banding technique and fluorescence in situ hybridization technique was applied using MYC breakapart probe (Cytocell. Results: Totally, in 2 of 25 cases available metaphases were not obtained. While in 9 of 23 cases were found to have normal karyotype (39.1%, numerical chromosomal abnormalities were detected in 6 cases, structural abnormalities in 4 and both numerical and structural abnormalities were found in 4 cases. In one case (4% t(8;14(q24;q32 was found as a cytogenetic aberration in which MYC gene locus involved.FISH analysis was performed successfully in all cases and MYC rearrangements were found in 3 cases (12% by FISH method. Conclusion: By comparing two techniques, it was observed that FISH method showed more sensitivity, however conventional cytogenetic techniques were also effective to reveal all changes of the chromosomes. Therefore, we concluded that it would be more efficient to useof these two techniques together.J Clin Exp Invest 2015;6 (1: 21-26

  11. Component fatigue rates drawn from measured load histories - Case study of a PWR surge line using FAMOS

    International Nuclear Information System (INIS)

    To guard against material fatigue, many German power plant utilities monitor fatigue-relevant plant items. In those instances where this is performed continuously and where data are stored permanently in digital form so as to be accessible to subsequent automatic computer processing, additional useful information on material fatigue is available. This is demonstrated by a case study of a PWR surge line. The study has been performed using the Siemens fatigue monitoring system FAMOS. Its three functional units comply with the three step strategy of data acquisition, data evaluation and fatigue calculation. The third unit is a new PC software tool completed recently and employed within the case study presented here. The measured load histories are used as input data. Fatigue rates are evaluated at pronounced locations of the plant items in question. FAMOS data acquisition has been in use at the Philippsburg 2 nuclear power plant since 1988. FAMOS fatigue calculation software now provides an elegant, rational approach to fatigue analysis. It stores the cumulative fatigue level for all of the positions monitored and can therefore continue fatigue analysis with the measured data that are collected

  12. Generating Representative Attack Test Cases for Evaluating and Testing Wireless Intrusion Detection Systems

    OpenAIRE

    Khalid Nasr; Anas Abou El Kalam; Christian Fraboul

    2012-01-01

    Openness of wireless communication medium and flexibility in dealing with wireless communication protocols and their vulnerabilities create a problem of poor security. Due to deficiencies in the security mechanisms of the first line of defense such as firewall and encryption, there are growing interests in detecting wireless attacks through a second line of defense in the form of Wireless Intrusion Detection System (WIDS). WIDS monitors the radio spectrum and system activities and detects att...

  13. A case-association cluster detection and visualisation tool with an application to Legionnaires’ disease

    Science.gov (United States)

    Sansom, P; Copley, V R; Naik, F C; Leach, S; Hall, I M

    2013-01-01

    Statistical methods used in spatio-temporal surveillance of disease are able to identify abnormal clusters of cases but typically do not provide a measure of the degree of association between one case and another. Such a measure would facilitate the assignment of cases to common groups and be useful in outbreak investigations of diseases that potentially share the same source. This paper presents a model-based approach, which on the basis of available location data, provides a measure of the strength of association between cases in space and time and which is used to designate and visualise the most likely groupings of cases. The method was developed as a prospective surveillance tool to signal potential outbreaks, but it may also be used to explore groupings of cases in outbreak investigations. We demonstrate the method by using a historical case series of Legionnaires’ disease amongst residents of England and Wales. PMID:23483594

  14. A case-association cluster detection and visualisation tool with an application to Legionnaires' disease.

    Science.gov (United States)

    Sansom, P; Copley, V R; Naik, F C; Leach, S; Hall, I M

    2013-09-10

    Statistical methods used in spatio-temporal surveillance of disease are able to identify abnormal clusters of cases but typically do not provide a measure of the degree of association between one case and another. Such a measure would facilitate the assignment of cases to common groups and be useful in outbreak investigations of diseases that potentially share the same source. This paper presents a model-based approach, which on the basis of available location data, provides a measure of the strength of association between cases in space and time and which is used to designate and visualise the most likely groupings of cases. The method was developed as a prospective surveillance tool to signal potential outbreaks, but it may also be used to explore groupings of cases in outbreak investigations. We demonstrate the method by using a historical case series of Legionnaires' disease amongst residents of England and Wales. PMID:23483594

  15. Early Detection of Plant Equipment Failures: A Case Study in Just-in-Time Maintenance

    International Nuclear Information System (INIS)

    The development and testing of a model-based fault detection system for electric motors is briefly presented. The fault detection system was developed using only motor nameplate information. The fault detection results presented utilize only motor voltage and current sensor information, minimizing the need for expensive or intrusive sensors. Dynamic recurrent neural networks are used to predict the input-output response of a three-phase induction motor while using an estimate of the motor speed signal. Multiresolution (or wavelet) signal-processing techniques are used in combination with more traditional methods to estimate fault features for use in winding insulation and motor mechanical and electromechanical failure detection

  16. Emperipolesis in a Case of Adult T Cell Lymphoblastic Lymphoma (Mediastinal type-Detected at FNAC and Imprint Cytology

    Directory of Open Access Journals (Sweden)

    Amita K

    2011-11-01

    Full Text Available Emperipolesis is a condition in which viable hematopoetic cells are seen intact in the cytoplasm of host cell without damage. This phenomenon is seen in many physiologic and pathologic conditions, its presence in Rosai Dorfman disease (RDD is characteristic of the disease. However emperipolesis is an uncommon finding in malignant lymphoma both Hodgkins and non-Hodgkin’s lymphoma, wherein it has been described in bone marrow aspirate and tissue culture. In contrast there are only two case reports of emperipolesis phenomenon described in non-Hodgkin’s lymphoma in tissue sections. We report a case of an adult T cell lymphoblastic lymphoma (mediastinal type with features of emperipolesis demonstrated at fine needle aspiration cytology (FNAC and imprint cytology of cervical lymph nodes. To our knowledge, this is the first case report of emperipolesis in a case of adult T cell lymphoblastic lymphoma (mediastinal type-detected at FNAC and imprint cytology.

  17. Automatic Case-Based Reasoning Approach for Landslide Detection: Integration of Object-Oriented Image Analysis and a Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Jie Dou

    2015-04-01

    Full Text Available This paper proposes an automatic method for detecting landslides by using an integrated approach comprising object-oriented image analysis (OOIA, a genetic algorithm (GA, and a case-based reasoning (CBR technique. It consists of three main phases: (1 image processing and multi-image segmentation; (2 feature optimization; and (3 detecting landslides. The proposed approach was employed in a fast-growing urban region, the Pearl River Delta in South China. The results of detection were validated with the help of field surveys. The experimental results indicated that the proposed OOIA-GA-CBR (0.87 demonstrates higher classification performance than the stand-alone OOIA (0.75 method for detecting landslides. The area under curve (AUC value was also higher than that of the simple OOIA, indicating the high efficiency of the proposed landslide detection approach. The case library created using the integrated model can be reused for time-independent analysis, thus rendering our approach superior in comparison to other traditional methods, such as the maximum likelihood classifier. The results of this study thus facilitate fast generation of accurate landslide inventory maps, which will eventually extend our understanding of the evolution of landscapes shaped by landslide processes.

  18. A broad-application microchannel-plate detector system for advanced particle or photon detection tasks large area imaging, precise multi-hit timing information and high detection rate

    CERN Document Server

    Jagutzki, O; Mergel, V; Schmidt-Böcking, H; Spielberger, L; Spillmann, U; Ullmann-Pfleger, K

    2002-01-01

    New applications for single particle and photon detection in many fields require both large area imaging performance and precise time information on each detected particle. Moreover, a very high data acquisition rate is desirable for most applications and eventually the detection and imaging of more than one particle arriving within a microsecond is required. Commercial CCD systems lack the timing information whereas other electronic microchannel plate (MCP) read-out schemes usually suffer from a low acquisition rate and complicated and sometimes costly read-out electronics. We have designed and tested a complete imaging system consisting of an MCP position readout with helical wire delay-lines, single-unit amplifier box and PC-controlled time-to-digital converter (TDC) readout. The system is very flexible and can detect and analyse position and timing information at single particle rates beyond 1 MHz. Alternatively, multi-hit events can be collected and analysed at about 20 kHz rate. We discuss the advantage...

  19. The Chemically Homogeneous Evolutionary Channel for Binary Black Hole Mergers: Rates and Properties of Gravitational-Wave Events Detectable by Advanced Ligo

    CERN Document Server

    de Mink, S E

    2016-01-01

    We explore the predictions for detectable gravitational-wave signals from merging binary black holes formed through chemically homogeneous evolution in massive short-period stellar binaries. We find that ~500 events per year could be detected with advanced ground-based detectors operating at full sensitivity. We analyze the distribution of detectable events, and conclude that there is a very strong preference for detecting events with nearly equal components (mass ratio >0.66 at 90% confidence in our default model) and high masses (total source-frame mass between 57 and $103\\, M_\\odot$ at 90% confidence). We consider multiple alternative variations to analyze the sensitivity to uncertainties in the evolutionary physics and cosmological parameters, and conclude that while the rates are sensitive to assumed variations, the mass distributions are robust predictions. Finally, we consider the recently reported results of the analysis of the first 16 double-coincident days of the O1 LIGO observing run, and find tha...

  20. A Novel Algorithm for Prediction and Detection of Hypoglycemia Based on Continuous Glucose Monitoring and Heart Rate Variability in Patients With Type 1 Diabetes

    DEFF Research Database (Denmark)

    Cichosz, Simon Lebech; Frystyk, Jan; Hejlesen, Ole K;

    2014-01-01

    Hypoglycemia is a common and serious side effect of insulin therapy in patients with diabetes. Early detection and prediction of hypoglycemia may improve treatment and avoidance of serious complications. Continuous glucose monitoring (CGM) has previously been used for detection of hypoglycemia, but...... insulin-induced hypoglycemia were obtained. Blood glucose samples were used as reference. HRV patterns and CGM data were combined in a mathematical prediction algorithm. Detection of hypoglycemic periods, performed by the algorithm, was treated as a pattern recognition problem and features...... with a modest accuracy. Therefore, our aim was to investigate whether a novel algorithm that adds information of the complex dynamic/pattern of heart rate variability (HRV) could improve the accuracy of hypoglycemia as detected by a CGM device. Data from 10 patients with type 1 diabetes studied during...

  1. Is the detection rate of 18F-choline PET/CT influenced by androgen-deprivation therapy?

    Energy Technology Data Exchange (ETDEWEB)

    Chondrogiannis, Sotirios; Marzola, Maria Cristina; Grassetto, Gaia; Maffione, Anna Margherita; Rampin, Lucia; Rubello, Domenico [' ' Santa Maria della Misericordia' ' Hospital, Rovigo (Italy). PET/CT Centre; Ferretti, Alice [' ' San Giacomo Apostolo' ' Hospital, Castelfranco Veneto, Treviso (Italy). Service of Medical Physics; Fanti, Stefano [Azienda Ospedaliero-Univ. Policlinico S. Orsola-Malpighi, Bologna (Italy). Dept. of Nuclear Medicine; Giammarile, Francesco [Lyon 1 Univ. Centre Hospitalier Lyon Sud Biophysique, Villeurbanne (Italy). Dept. of Nuclear Medicine

    2014-07-15

    To evaluate if the detection rate (DR) of {sup 18}F-choline (18F-CH) PET/CT is influenced by androgen-deprivation therapy (ADT) in patients with prostate cancer (PC) already treated with radical intent and presenting biochemical relapse. We have retrospectively evaluated {sup 18}F-CH PET/CT scans of 325 consecutive PC patients enrolled in the period November 2009 to December 2012 previously treated with radical intent and referred to our centre to perform {sup 18}F-CH PET/CT for biochemical relapse. Two different groups of patients were evaluated. group A included the whole sample of 325 patients (mean age 70 years, range: 49-86) who presented trigger PSA between 0.1 and 80 ng/ml (mean 5.5 ng/ml), and group B included 187 patients (mean age 70 years, range 49-86) with medium-low levels of trigger PSA ranging between 0.5 and 5 ng/ml (mean PSA 2.1 ng/ml); group B was chosen in order to obtain a more homogeneous group of patients in terms of PSA values also excluding both very low and very high PSA levels avoiding the ''a priori'' higher probability of negative or positive PET scan, respectively. At the time of examination, 139 patients from group A and 72 patients from group B were under ADT: these patients were considered to be hormone-resistant PC patients because from their oncologic history (>18 months) an increase of PSA levels emerged despite the ongoing ADT. The relationship between {sup 18}F-CH PET/CT findings and possible clinical predictors was investigated using both univariate and multivariate binary logistic regression analyses, including trigger PSA and ADT. Considering the whole population, overall DR of {sup 18}F-CH PET was 58.2 % (189/325 patients). In the whole sample of patients (group A), both at the univariate and multivariate logistic regression analysis, trigger PSA and ADT were significantly correlated with the DR of {sup 18}F-CH PET (p < 0.05). Moreover, the DR in patients under ADT (mean PSA 7.8 ng/ml) was higher than in

  2. Health Monitoring of Offshore Wind Turbines Online Fault Detection and Identification Module Test Case: Pitch Offset

    DEFF Research Database (Denmark)

    Perisic, Nevena; Pedersen, Bo Juul; Kirkegaard, Poul Henning

    LACobserver is a model based health monitoring (HM) system for wind turbines (WTGs) which provides an intuitive engineering link between load and strength parameters. The present work demonstrates a newly developed LACobserver Fault Detection and Identification (FDI) module for online detection o...

  3. Comparison of Some Motion Detection Methods in cases of Single and Multiple Moving Objects

    Directory of Open Access Journals (Sweden)

    Shamir Alavi

    2012-10-01

    Full Text Available Motion detection tells us whether there is a change in position of an object with respect to its surroundings or vice versa. It is applied to various domestic and commercial applications starting from simple motion detectors to high speed video surveillance systems. In this paper, results obtained from some simple motion detection algorithms, which use methods like image subtraction and edge detection, have been compared. The software used for this purpose was MATLAB 7.6.0 (R2008a. It has been observed that while image subtraction is sufficient to detect motion in a video stream, combining it with edge detection in different sequences yields different results in different scenarios.

  4. A Case of Primary Colon Carcinoma Demonstrated by FDG PET/CT Imaging After Detection of a Solitary Brain Metastasis

    Directory of Open Access Journals (Sweden)

    Seval Erhamamcı

    2015-06-01

    Full Text Available The detection of brain metastases as the initial manifestation of colorectal carcinoma without liver or lung involvement is extremely rare. Herein we present a case of a 52-year-old male patient with an unusual presentation of colon cancer, with primary lesions demonstrated by fluorine-18-labeled fluorodeoxyglucose (FDG Positron-emission tomography/computed tomography (PET/CT after detection of a solitary brain metastasis. Brain CT images revealed a brain tumor. Histopathologic evaluation indicated metastatic poorly differentiated adenocarcinoma, while his physical examination was normal. The PET/ CT revealed abnormal intense FDG uptake in the right parietal region and in descending colon, with no other abnormal FDG uptake elsewhere in the body. The histopathologic diagnosis of the descending colon lesion revealed moderately differentiated adenocarcinoma. This case indicates that FDG PET/CT imaging may have a positive impact on the evaluation of patients with brain metastasis from an unknown primary.

  5. Quench detection and behaviour in case of quench in the ITER magnet systems

    International Nuclear Information System (INIS)

    The quench of one of the ITER magnet system is an irreversible transition from superconducting to normal resistive state, of a conductor. This normal zone propagates along the cable in conduit conductor dissipating a large power. The detection has to be fast enough to dump out the magnetic energy and avoid irreversible damage of the systems. The primary quench detection in ITER is based on voltage detection, which is the most rapid detection. The very magnetically disturbed environment during the plasma scenario makes the voltage detection particularly difficult, inducing large inductive components in the coils and voltage compensations have to be designed to discriminate the resistive voltage associated with the quench. A conceptual design of the quench detection based on voltage measurements is proposed for the three majors magnet systems of ITER. For this, a clear methodology was developed. It includes the classical hot spot criterion, the quench propagation study using the commercial code Gandalf and the careful estimation of the inductive disturbances by developing the TrapsAV code. Specific solutions have been proposed for the compensation in the three ITER magnet systems and for the quench detection parameters, which are the voltage threshold (in the range of 0.1 V - 0.55 V) and the holding time (in the range of 1-1.4 s). The selected values, in particular the holding time, are sufficiently high to ensure the reliability of the system and avoid fast safety discharges not induced by a quench, which is a classical problem. (author)

  6. Influence of Flexible Crop Yield Distribution on Crop Insurance Premium Rate - A Case Study on Cotton Insurance in Three Areas of Xinjiang

    OpenAIRE

    Wang, Ke; Zhang, Qiao

    2012-01-01

    Based on theoretical analysis of crop risk and premium rate setting, we take the case of premium rate setting of insurance on cotton yield per unit area in Shache County, Shaya County and Aksu City of Xinjiang. Using parametric methods and insurance actuarial technique, we select the optimal model for risk fitting of cotton yield per unit area in three areas; compare the premium rate calculated accurately under four risk distribution assumptions of cotton yield per unit area, and the rational...

  7. The passage of cells can improve the detection rate of avian leukosis virus to facilitate the elimination of avian leukosis in chickens

    OpenAIRE

    Wang, Xiuzhen; Wang, Bo; Zhang, Peipei; Cheng, Hegang; Sun, Shuhong

    2013-01-01

    Avian leukosis (AL) is one of the most harmful diseases to the poultry industry in China. The detection of the avian leukosis virus (ALV) p27 antigen plays a decisive role in the elimination of avian leukosis. To explore the influence of passaging cells on the detection rate of the ALV p27 antigen, 21 aseptic anticoagulated blood samples were collected from 21 chickens for which the cloacal swabs were positive for the p27 antigen to inoculate two sets of cell culture plates containing DF1 cel...

  8. Malaria case detection using rapid diagnostic test at the community level in Ghana: consumer perception and practitioners’ experiences

    OpenAIRE

    Danquah, Daniel A.; Buabeng, Kwame O; Asante, Kwaku P; Mahama, Emmanuel; Bart-Plange, Constance; Owusu-Dabo, Ellis

    2016-01-01

    Background Ghana has scaled-up malaria control strategies over the past decade. Much as malaria morbidity and mortality seem to have declined with these efforts, there appears to be increased consumption of artemisinin-based combination therapy (ACT). This study explored the perception and experiences of community members and medicines outlet practitioners on malaria case detection using rapid diagnostic test (RDTs) to guide malaria therapy. Methods This was a cross-sectional study using both...

  9. Detecting The Expected Rate of Return Volatility of Financing Instruments of Indonesian Islamic Banking through GARCH Modeling (Generalized Autoregressive Conditional Heteroscedasticity

    Directory of Open Access Journals (Sweden)

    Nurul Huda

    2015-04-01

    Full Text Available Objective - Islamic banks are banks which its activities, both fund raising and funds distribution are on the basis of Islamic principles, namely buying and selling and profit sharing. Islamic banking is aimed at supporting the implementation of national development in order to improve justice, togetherness, and equitable distribution of welfare. In pursuit of supporting the implementation of national development, Islamic banking often faced stability problems of financing instruments being operated. In this case, it is measured by the gap between the actual rate of return and the expected rate of return. The individual actual RoR of this instrument will generate an expected rate of return. This raises the gap or difference between the actual rate of return and the expected rate of return of individual instruments, which in this case is called the abnormal rate of return. The stability of abnormal rate of return of individual instruments is certainly influenced by the stability of the expected rate of return. Expected rate of return has a volatility or fluctuation levels for each financing instrument. It is also a key element or material basis for the establishment of a variance of individual instruments. Variance in this case indicates the level of uncertainty of the rate of return. Individual variance is the origin of the instrument base for variance in the portfolio finance that further a portfolio analysis. So, this paper is going to analyze the level of expected RoR volatility as an initial step to see and predict the stability of the fluctuations in the rate of return of Indonesian Islamic financing instruments.Methods – Probability of Occurence, Expected Rate of Return (RoR and GARCH (Generalized Autoregressive Conditional Heteroscedasticity.Results - The expected RoR volatility of the murabaha and istishna financing instruments tend to be more volatile than expected RoR volatility of musharaka and qardh financing instruments

  10. Measurement of the track etch rates along proton and alpha particle trajectories in CR-39 and calculation of the detection efficiency

    CERN Document Server

    Dörschel, B; Hermsdorf, D; Kadner, K; Kuehne, H

    1999-01-01

    Computation of the neutron response of CR-39 detectors needs to simulate the track formation by neutron induced charged particles taking into account the bulk etch rate and the track etch rate varying along the particle trajectories. The latter one was determined experimentally by track length measurement. The results allowed to derive the relationship between the track etch rate and the restricted energy loss of the charged particles. On this basis, the geometrical track parameters and track etch rates as well as the critical angle of particle incidence could be determined for protons and alpha particles in the energy range from 0.2 to 8.8 MeV. The energy dependence of the critical angle enabled to determine the detection efficiency for a charged particle of given energy and direction.

  11. Gender Difference or Indifference? Detective Decision Making in Sexual Assault Cases

    Science.gov (United States)

    Alderden, Megan A.; Ullman, Sarah E.

    2012-01-01

    Prior research examining sexual assault case decision making has failed to account for the demographic characteristics of the criminal justice practitioners charged with making case decisions. Inclusion of such information is important because it provides researchers with a greater understanding of how criminal justice practitioners' own gender,…

  12. Development and Application of an Alert System to Detect Cases of Food Poisoning in Japan

    OpenAIRE

    Akie Maeyashiki; Manabu Akahane; Hiroaki Sugiura; Yasushi Ohkusa; Nobuhiko Okabe; Tomoaki Imamura

    2016-01-01

    Recent public health concerns regarding commercial food products have increased the need to develop an automated method to detect food product-related health events. We developed and verified a method for the early detection of potentially harmful events caused by commercial food products. We collected data from daily internet-based questionnaires examining the presence or absence of symptoms and information about food purchased by the respondents. Using these data, we developed a method to d...

  13. Identification of hidden allergens. The case of detection of pistachio traces in mortadella.

    OpenAIRE

    Barbieri, Giampiero; Frigeri, Giorgia

    2006-01-01

    Abstract An analytical method based on the detection of specific DNAs was defined, and was applied to mortadella samples with and without pistachio (Pistacia Vera), in order to detect traces deriving from previous processes or from accidental contamination, since in predisposed individuals pistachios can cause allergic reactions leading to anaphylactic shock. Three pairs of primers were defined and tested for PCR on mortadella samples prepared with pistachio. Accidental contamin...

  14. Prevalence rate of thyroid diseases among autopsy cases of the atomic bomb survivors in Hiroshima, 1951-1985

    International Nuclear Information System (INIS)

    To examine the radiogenic risk of latent thyroid cancer, thyroid adenoma, colloid/adenomatous goiter and chronic thyroiditis, the date for 3821 subjects collected in the course of autopsies of atomic bomb survivors in Hiroshima from 1951 to 1985 by the Radiation Effects Research Foundation (RERF) were analyzed using a logistic model. About 80% of the autopsies were performed at RERF and the remainder at local hospitals. The frequencies of the above diseases were not associated with whether the underlying cause of death was cancer. However, note that our results may be influenced by potentially biasing factors associated with autopsy selection. The relative frequency of latent thyroid cancer (greatest dimension ≤1.5 cm but detectable on a routine microscopic slide of the thyroid gland) increased as the radiation dose increased and was about 1.4-fold greater at 1 Gy than in the 0-Gy dose group. The relative occurrence of thyroid adenoma also increased as radiation dose increased, and was about 1.5-fold greater at 1 Gy than in the 0-Gy dose group. Sex, age at the time of the bombing or period of observation did not significantly modify the radiogenic risks for thyroid adenoma or latent thyroid cancer. No statistically significant association was found between radiation exposure and the rates of colloid/adenomatous goiter and chronic thyroiditis. The possible late effect of atomic bomb radiation on the frequency of benign thyroid diseases is discussed on the basis of these data. 38 refs., 2 figs., 5 tabs

  15. Influence of cigarette smoking in the rate pressure product among young adults: a case control study from Manipal, India.

    Directory of Open Access Journals (Sweden)

    Mulki Ganesh Kamath

    2015-12-01

    Full Text Available Background Cigarette smoking is an important cause of mortality across the world, resulting in death of nearly six million people. Nearly 40% of the deaths are caused by cardiovascular disease and 20% are due to lung cancer. Cigarette smoking is said to increase the susceptibility towards vascular injuries by impacting phases of atherosclerosis, and altering blood pressure (BP, heart rate (HR and elevating plasma catecholamine levels. The objective of this study was to assess if cigarette smoking increases the rate pressure product (RPP at rest and after standing in young adult light smokers compared to non-smokers. Methods 30 young adult smokers and 30 non-smokers (19 - 24 years were enrolled in this case control study. The smoking pack-years was calculated. Blood pressure (BP was measured and RPP was calculated. The mean values between both groups were compared using the univariate analysis of variance adjusted for confounding variables. Results The smoking pack-years was 1.6±1.0 (0.2-4.5. RPP in smokers was 88.8±8.0, 96.2±10.2 at rest and after standing respectively. RPP in non-smokers at rest was 81.6±8.1 and 89.5±10.3 after standing. RPP was statistically significant in between both groups at rest. Conclusion Smoking increases the RPP significantly in young adult light smokers due to an increased HR when compared to non-smokers, at rest. This study reinforces that young adults who are light smokers have an increased workload on the heart, which affects their cardiac performance.

  16. Monetary and Exchange Rate Regimes Changes: The Cases of Poland, Czech Republic, Slovakia and Republic of Serbia

    OpenAIRE

    Josifidis Kosta; Allegret Jean-Pierre; Beker-Pucar Emilija

    2009-01-01

    The paper explores (former) transition economies, Poland, Czech Republic, Slovakia and the Republic of Serbia, concerning abandonment of the exchange rate targeting and fixed exchange rate regimes and movement toward explicit/implicit inflation targeting and flexible exchange rate regimes. The paper identifies different subperiods concerning crucial monetary and exchange rate regimes, and tracks the changes of specific monetary transmission channels i.e exchange rate channel, interest rate ch...

  17. Molecular detection of the carriage rate of four intestinal protozoa with real-time polymerase chain reaction

    DEFF Research Database (Denmark)

    Efunshile, Michael A; Ngwu, Bethrand A F; Kurtzhals, Jørgen A L;

    2015-01-01

    -Saharan countries. To overcome sensitivity issues related to microscopic detection and identification of cysts in stool concentrates, real-time polymerase chain reaction (PCR) was used to analyze genomic DNAs extracted from stool samples from 199 healthy school children for Entamoeba histolytica, E. dispar, Giardia...... intestinalis, and Cryptosporidium. Questionnaires were administered for epidemiological data collection. E. histolytica was not detected in any of the samples, whereas Giardia (37.2%), E. dispar (18.6%), and Cryptosporidium (1%) were found. Most of the children sourced their drinking water from community wells...... (91%), while the majority disposed of feces in the bush (81.9%). Our study is the first to use real-time PCR to evaluate the epidemiology of E. histolytica, Giardia, and Cryptosporidium in Nigeria where previous studies using traditional diagnostic techniques have suggested higher and lower carriage...

  18. Detection of atrial high-rate events by continuous Home Monitoring: clinical significance in the heart failure–cardiac resynchronization therapy population

    OpenAIRE

    Shanmugam, Nesan; Boerdlein, Annegret; Proff, Jochen; Ong, Peter; Valencia, Oswaldo; Maier, Sebastian K. G.; Bauer, Wolfgang R; Paul, Vince; Sack, Stefan

    2011-01-01

    Aims Uncertainty exists over the importance of device-detected short-duration atrial arrhythmias. Continuous atrial diagnostics, through home monitoring (HM) technology (BIOTRONIK, Berlin, Germany), provides a unique opportunity to assess frequency and quantity of atrial fibrillation (AF) episodes defined as atrial high-rate events (AHRE). Methods and results Prospective data from 560 heart failure (HF) patients (age 67 ± 10 years, median ejection fraction 27%) patients with a cardiac resynch...

  19. Mean Polyp per Patient Is an Accurate and Readily Obtainable Surrogate for Adenoma Detection Rate: Results from an Opportunistic Screening Colonoscopy Program

    OpenAIRE

    Delavari, Alireza; Salimzadeh, Hamideh; Bishehsari, Faraz; Sobh Rakhshankhah, Elham; Delavari, Farnaz; Moossavi, Shirin; Khosravi, Pejman; Nasseri-Moghaddam, Siavosh; Merat, Shahin; Ansari, Reza; Vahedi, Homayoon; Shahbazkhani, Bijan; Saberifiroozi, Mehdi; Sotoudeh, Masoud; Malekzadeh, Reza

    2015-01-01

    BACKGROUND The incidence of colorectal cancer is rising in several developing countries. In the absence of integrated endoscopy and pathology databases, adenoma detection rate (ADR), as a validated quality indicator of screening colonoscopy, is generally difficult to obtain in practice. We aimed to measure the correlation of polyp-related indicators with ADR in order to identify the most accurate surrogate(s) of ADR in routine practice. METHODS We retrospectively reviewed the endoscopic and h...

  20. Modeling kinetic rate variation in third generation DNA sequencing data to detect putative modifications to DNA bases.

    Science.gov (United States)

    Schadt, Eric E; Banerjee, Onureena; Fang, Gang; Feng, Zhixing; Wong, Wing H; Zhang, Xuegong; Kislyuk, Andrey; Clark, Tyson A; Luong, Khai; Keren-Paz, Alona; Chess, Andrew; Kumar, Vipin; Chen-Plotkin, Alice; Sondheimer, Neal; Korlach, Jonas; Kasarskis, Andrew

    2013-01-01

    Current generation DNA sequencing instruments are moving closer to seamlessly sequencing genomes of entire populations as a routine part of scientific investigation. However, while significant inroads have been made identifying small nucleotide variation and structural variations in DNA that impact phenotypes of interest, progress has not been as dramatic regarding epigenetic changes and base-level damage to DNA, largely due to technological limitations in assaying all known and unknown types of modifications at genome scale. Recently, single-molecule real time (SMRT) sequencing has been reported to identify kinetic variation (KV) events that have been demonstrated to reflect epigenetic changes of every known type, providing a path forward for detecting base modifications as a routine part of sequencing. However, to date no statistical framework has been proposed to enhance the power to detect these events while also controlling for false-positive events. By modeling enzyme kinetics in the neighborhood of an arbitrary location in a genomic region of interest as a conditional random field, we provide a statistical framework for incorporating kinetic information at a test position of interest as well as at neighboring sites that help enhance the power to detect KV events. The performance of this and related models is explored, with the best-performing model applied to plasmid DNA isolated from Escherichia coli and mitochondrial DNA isolated from human brain tissue. We highlight widespread kinetic variation events, some of which strongly associate with known modification events, while others represent putative chemically modified sites of unknown types. PMID:23093720

  1. Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay

    Science.gov (United States)

    Schwaederle, Maria; Husain, Hatim; Fanta, Paul T.; Piccioni, David E.; Kesari, Santosh; Schwab, Richard B.; Banks, Kimberly C.; Lanman, Richard B.; Talasaz, AmirAli; Parker, Barbara A.; Kurzrock, Razelle

    2016-01-01

    Analysis of cell-free DNA using next-generation sequencing (NGS) is a powerful tool for the detection/monitoring of alterations present in circulating tumor DNA (ctDNA). Plasma extracted from 171 patients with a variety of cancers was analyzed for ctDNA (54 genes and copy number variants (CNVs) in three genes (EGFR, ERBB2 and MET)). The most represented cancers were lung (23%), breast (23%), and glioblastoma (19%). Ninety-nine patients (58%) had at least one detectable alteration. The most frequent alterations were TP53 (29.8%), followed by EGFR (17.5%), MET (10.5%), PIK3CA (7%), and NOTCH1 (5.8%). In contrast, of 222 healthy volunteers, only one had an aberration (TP53). Ninety patients with non-brain tumors had a discernible aberration (65% of 138 patients; in 70% of non-brain tumor patients with an alteration, the anomaly was potentially actionable). Interestingly, nine of 33 patients (27%) with glioblastoma had an alteration (6/33 (18%) potentially actionable). Overall, sixty-nine patients had potentially actionable alterations (40% of total; 69.7% of patients (69/99) with alterations); 68 patients (40% of total; 69% of patients with alterations), by a Food and Drug Administration (FDA) approved drug. In summary, 65% of diverse cancers (as well as 27% of glioblastomas) had detectable ctDNA aberration(s), with the majority theoretically actionable by an approved agent. PMID:26848768

  2. Defining Treatment Response and Remission in Child Anxiety: Signal Detection Analysis Using the Pediatric Anxiety Rating Scale

    Science.gov (United States)

    Caporino, Nicole E.; Brodman, Douglas M.; Kendall, Philip C.; Albano, Anne Marie; Sherrill, Joel; Piacentini, John; Sakolsky, Dara; Birmaher, Boris; Compton, Scott N.; Ginsburg, Golda; Rynn, Moira; McCracken, James; Gosch, Elizabeth; Keeton, Courtney; March, John; Walkup, John T.

    2013-01-01

    Objective: To determine optimal Pediatric Anxiety Rating Scale (PARS) percent reduction and raw score cut-offs for predicting treatment response and remission among children and adolescents with anxiety disorders. Method: Data were from a subset of youth (N = 438; 7-17 years of age) who participated in the Child/Adolescent Anxiety Multimodal Study…

  3. The agreement rate of rose Bengal, modified rose Bengal and rapid Wright tests for detection of positive serum sample of Brucellosis

    Directory of Open Access Journals (Sweden)

    Ali Gorgeen Karaji

    2011-03-01

    Full Text Available Background: Rose Bengal is a common test for serologic diagnosis of brucellosis. The aim of this study was to evaluate the agreement rate between modified rose Bengal, rose Bengal and rapid Wright tests for detection of antibody positive serum samples. Methods: Cross section study was designed. 941 serum sample of patients referred to the central medical laboratory of Kermanshah, were evaluated by rose Bengal, modified rose Bengal and rapid Wright, using convenient sampling method. Positive samples were confirmed and their titers were defined by Wright agglutination test. Results: The number of positive serum samples with modified rose Bengal was two fold higher than conventional rose Bengal test (P<0.001, which included all positive samples with rose Bengal. On the other hand, although the number of positive diagnosed serum samples with modified rose Bengal were nearly two times more than Wright test (P<0.001, but it did not include all positive samples detected by Wright test. All three tests showed acceptable agreement rate (k≥0.583.Conclusion: Results of this study confirmed that modified rose Bengal able to detect more positive serum sample than conventional rose Bengal and it would be substituted rose Bengal. However, the rapid Wright test should be used aside with modified rose Bengal, because it could not cover all positive samples detected by rapid Wright test.

  4. Multi-Target Tracking With Time-Varying Clutter Rate and Detection Profile: Application to Time-Lapse Cell Microscopy Sequences.

    Science.gov (United States)

    Rezatofighi, Seyed Hamid; Gould, Stephen; Vo, Ba Tuong; Vo, Ba-Ngu; Mele, Katarina; Hartley, Richard

    2015-06-01

    Quantitative analysis of the dynamics of tiny cellular and sub-cellular structures, known as particles, in time-lapse cell microscopy sequences requires the development of a reliable multi-target tracking method capable of tracking numerous similar targets in the presence of high levels of noise, high target density, complex motion patterns and intricate interactions. In this paper, we propose a framework for tracking these structures based on the random finite set Bayesian filtering framework. We focus on challenging biological applications where image characteristics such as noise and background intensity change during the acquisition process. Under these conditions, detection methods usually fail to detect all particles and are often followed by missed detections and many spurious measurements with unknown and time-varying rates. To deal with this, we propose a bootstrap filter composed of an estimator and a tracker. The estimator adaptively estimates the required meta parameters for the tracker such as clutter rate and the detection probability of the targets, while the tracker estimates the state of the targets. Our results show that the proposed approach can outperform state-of-the-art particle trackers on both synthetic and real data in this regime. PMID:25594963

  5. A Comparison Between Data Mining Prediction Algorithms for Fault Detection(Case study: Ahanpishegan co.)

    CERN Document Server

    Amooee, Golriz; Bagheri-Dehnavi, Malihe

    2012-01-01

    In the current competitive world, industrial companies seek to manufacture products of higher quality which can be achieved by increasing reliability, maintainability and thus the availability of products. On the other hand, improvement in products lifecycle is necessary for achieving high reliability. Typically, maintenance activities are aimed to reduce failures of industrial machinery and minimize the consequences of such failures. So the industrial companies try to improve their efficiency by using different fault detection techniques. One strategy is to process and analyze previous generated data to predict future failures. The purpose of this paper is to detect wasted parts using different data mining algorithms and compare the accuracy of these algorithms. A combination of thermal and physical characteristics has been used and the algorithms were implemented on Ahanpishegan's current data to estimate the availability of its produced parts. Keywords: Data Mining, Fault Detection, Availability, Predictio...

  6. Monetary autonomy under different exchange rate regimes in the long-run: the case of seven new EU countries

    Directory of Open Access Journals (Sweden)

    Yu HSING

    2013-05-01

    Full Text Available This paper finds that except for Poland, the other six countries possess moderate or significant monetary autonomy in the long run as their interest rates make partial or small adjustments to a change in the Euro area interest rate. Except for the Czech Republic and Poland, the findings support the hypothesis that countries under more flexible exchange rate regimes possess more monetary autonomy than countries under less flexible exchange rate regimes because local interest rates under more flexible exchange rate regimes are less sensitive to a change in the euro area interest rate.

  7. Multiple Kernel Learning for Heterogeneous Anomaly Detection: Algorithm and Aviation Safety Case Study

    Data.gov (United States)

    National Aeronautics and Space Administration — The world-wide aviation system is one of the most complex dynamical systems ever developed and is generating data at an extremely rapid rate. Most modern commercial...

  8. Signal to Noise Ratio Estimations for a Volcanic ASH Detection Lidar. Case Study: The Met Office

    Science.gov (United States)

    Georgoussis, George; Adam, Mariana; Avdikos, George

    2016-06-01

    In this paper we calculate the Signal-to-Noise (SNR) ratio of a 3-channel commercial (Raymetics) volcanic ash detection system, (LR111-D300), already operating under Met Office organization. The methodology for the accurate estimation is presented for day and nighttime conditions. The results show that SNR values are higher than 10 for ranges up to 13 km for both nighttime and daytime conditions. This is a quite good result compared with other values presented in bibliography and proves that such system is able to detect volcanic ash over a range of 20 km.

  9. Monetary autonomy under different exchange rate regimes in the long-run: the case of seven new EU countries

    OpenAIRE

    Hsing, Yu

    2013-01-01

    This paper finds that except for Poland, the other six countries possess moderate or significant monetary autonomy in the long run as their interest rates make partial or small adjustments to a change in the Euro area interest rate. Except for the Czech Republic and Poland, the findings support the hypothesis that countries under more flexible exchange rate regimes possess more monetary autonomy than countries under less flexible exchange rate regimes because local interest rates under more f...

  10. MR Imaging of Pulmonary Nodules: Detection Rate and Accuracy of Size Estimation in Comparison to Computed Tomography

    Science.gov (United States)

    Cieszanowski, Andrzej; Lisowska, Antonina; Dabrowska, Marta; Korczynski, Piotr; Zukowska, Malgorzata; Grudzinski, Ireneusz P.; Pacho, Ryszard; Rowinski, Olgierd; Krenke, Rafal

    2016-01-01

    Objective The aims of this study were to assess the sensitivity of various magnetic resonance imaging (MRI) sequences for the diagnosis of pulmonary nodules and to estimate the accuracy of MRI for the measurement of lesion size, as compared to computed tomography (CT). Methods Fifty patients with 113 pulmonary nodules diagnosed by CT underwent lung MRI and CT. MRI studies were performed on 1.5T scanner using the following sequences: T2-TSE, T2-SPIR, T2-STIR, T2-HASTE, T1-VIBE, and T1-out-of-phase. CT and MRI data were analyzed independently by two radiologists. Results The overall sensitivity of MRI for the detection of pulmonary nodules was 80.5% and according to nodule size: 57.1% for nodules ≤4mm, 75% for nodules >4-6mm, 87.5% for nodules >6-8mm and 100% for nodules >8mm. MRI sequences yielded following sensitivities: 69% (T1-VIBE), 54.9% (T2-SPIR), 48.7% (T2-TSE), 48.7% (T1-out-of-phase), 45.1% (T2-STIR), 25.7% (T2-HASTE), respectively. There was very strong agreement between the maximum diameter of pulmonary nodules measured by CT and MRI (mean difference -0.02 mm; 95% CI –1.6–1.57 mm; Bland-Altman analysis). Conclusions MRI yielded high sensitivity for the detection of pulmonary nodules and enabled accurate assessment of their diameter. Therefore it may be considered an alternative to CT for follow-up of some lung lesions. However, due to significant number of false positive diagnoses, it is not ready to replace CT as a tool for lung nodule detection. PMID:27258047

  11. Automated Algorithm for Generalized Tonic–Clonic Epileptic Seizure Onset Detection Based on sEMG Zero-Crossing Rate

    DEFF Research Database (Denmark)

    Conradsen, Isa; Beniczky, Sándor; Hoppe, Karsten; Wolf, Peter; Sørensen, Helge Bjarup Dissing

    2012-01-01

    Patients are not able to call for help during a generalized tonic–clonic epileptic seizure. Our objective was to develop a robust generic algorithm for automatic detection of tonic–clonic seizures, based on surface electromyography (sEMG) signals suitable for a portable device. Twenty-two seizures...... were analyzed from 11 consecutive patients. Our method is based on a high-pass filtering with a cutoff at 150 Hz, and monitoring a count of zero crossings with a hysteresis of $\\pm 50\\,\\mu \\hbox{V}$ . Based on data from one sEMG electrode (on the deltoid muscle), we achieved a sensitivity of 100% with...

  12. Detectability of the Eurasian otter by standard surveys: an approach using marking intensity to estimate false negative rates

    Science.gov (United States)

    Balestrieri, Alessandro; Remonti, Luigi; Prigioni, Claudio

    2011-01-01

    False negative detections may bias the surveys for rare species and reduce the reliability of models based on the proportion of occupied patches. We assessed the detectability of the Eurasian otter Lutra lutra through the standard survey method by analysing the detection history of 28 sampling stretches surveyed monthly between March 2001 and January 2003. Each survey negative for otter spraints was considered as a false negative if the otter had been recorded in the previous and/or following month (respectively, cFN and FN). Otter marking intensity (MI) (MI=N° of spraints per kilometre) was calculated and assumed to represent an index of its relative abundance. Spraints were found in 81.7% of all surveys. Yearly MI ranged from 1.02 to 101.4 spraints per kilometre. In 2002, mean MI was significantly lower than in the previous year, while no clear seasonal trend could be outlined. The minimum number of surveys required to establish the occurrence of the otter, as estimated by a probability model, was 2.6 and was inversely related to MI. For a sub-sample of 18 sampling stretches, the relation between the frequency of both cFN and FN and five variables of potential interest for otters was tested by means of stepwise linear multiple regressions, yielding two highly significant models, which both included only MI as the explanatory variable. The frequency of both FN and cFN was correlated to MI and the resulting equations used to assess the percentage of surveys positive for otters in both years. After the correction for non-detections, otter site occupancy did not vary between the 2 years, except for one river when applying the more conservative estimate of false negatives (cFN). Multiple visits and the assessing of MI should become standard components of otter surveys. This approach has broad applicability and may be applied to assess the large-scale distribution of other rare or elusive mammalian carnivores.

  13. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate

    DEFF Research Database (Denmark)

    Andreassen, Ole A; Thompson, Wesley K; Schork, Andrew J;

    2013-01-01

    are currently lacking. Here, we use a genetic pleiotropy-informed conditional false discovery rate (FDR) method on GWAS summary statistics data to identify new loci associated with schizophrenia (SCZ) and bipolar disorders (BD), two highly heritable disorders with significant missing heritability...... associated with both SCZ and BD (conjunction FDR). Together, these findings show the feasibility of genetic pleiotropy-informed methods to improve gene discovery in SCZ and BD and indicate overlapping genetic mechanisms between these two disorders....

  14. Reporting detection of Chlamydia trachomatis DNA in tissues of neonatal death cases

    Directory of Open Access Journals (Sweden)

    Maria Hernandez Trejo

    2014-04-01

    Full Text Available OBJECTIVE: to determine whether C. trachomatis was present in neonates with infection, but without an isolated pathogen, who died during the first week of life. METHODS: early neonatal death cases whose causes of death had been previously adjudicated by the institutional mortality committee were randomly selected. End-point and real-time polymerase chain reaction of the C. trachomatis omp1 gene was used to blindly identify the presence of chlamydial DNA in the paraffinized samples of five organs (from authorized autopsies of each of the dead neonates. Additionally, differential diagnoses were conducted by amplifying a fragment of the 16S rRNA of Mycoplasma spp. RESULTS: in five cases (35.7%, C. trachomatis DNA was found in one or more organs. Severe neonatal infection was present in three cases; one of them corresponded to genotype D of C. trachomatis. Interestingly, another case fulfilled the same criteria but had a positive polymerase chain reaction for Mycoplasma hominis, a pathogen known to produce sepsis in newborns. CONCLUSION: the use of molecular biology techniques in these cases of early infant mortality demonstrated that C. trachomatis could play a role in the development of severe infection and in early neonatal death, similarly to that observed with Mycoplasma hominis. Further study is required to determine the pathogenesis of this perinatal infection.

  15. An analysis of LULC change detection using remotely sensed data; A Case study of Bauchi City

    International Nuclear Information System (INIS)

    Bauchi is one of the cities in the north eastern part of Nigeria that has witnessed tremendous expansion as a result of rapid urbanization. For the past decade, the city has been known to be relatively small both in size and population. But today, Bauchi is one of the fastest growing cities in northern Nigeria. Therefore, it is paramount to detect the nature and magnitude of these changes in order to determine its direction of future expansion. To achieve that, Remotely Sensed data from Landsat 7 ETM+ and Landsat 8 were utilized for the purpose of LULC change detection in Bauchi city. Landsat 7 image of 2003 and Landsat 8 image of 2013 were obtained for the purpose of the study. Three change detection algorithms were used to detect areas of change. They include supervised, unsupervised and post classification comparison. While the unsupervised classification was found to be less effective, the supervised classification produced good results with overall accuracies of 93.5% and 89.7% for the 2003 and 2013 respectively. Finally, ''from-to'' change was obtained using the post classification comparism

  16. Corine land cover change detection in Europe (case studies of the Netherlands and Slovakia)

    NARCIS (Netherlands)

    Feranec, J.; Hazeu, G.W.; Christensen, S.; Jaffrain, G.

    2007-01-01

    We present a land cover change detection methodology in the framework of the IMAGE and CORINE Land Cover 2000 (I&CLC2000) project managed jointly by the European Environment Agency in Copenhagen, Denmark and the Joint Research Centre of the European Commission in Ispra, Italy. The generated data

  17. Development and Application of an Alert System to Detect Cases of Food Poisoning in Japan

    Science.gov (United States)

    Akahane, Manabu; Sugiura, Hiroaki; Ohkusa, Yasushi; Okabe, Nobuhiko; Imamura, Tomoaki

    2016-01-01

    Recent public health concerns regarding commercial food products have increased the need to develop an automated method to detect food product-related health events. We developed and verified a method for the early detection of potentially harmful events caused by commercial food products. We collected data from daily internet-based questionnaires examining the presence or absence of symptoms and information about food purchased by the respondents. Using these data, we developed a method to detect possible health concerns regarding commercialized food products. To achieve this, we combined the signal detection method used in the reporting system of adverse effects of pharmaceutical products and the Early Aberration Reporting System (EARS) used by the United States Centers for Disease Control. Whiteleg shrimp (Litopenaeus vannamei), which had odds ratio and Odds(−) of 8.99 and 4.13, respectively, was identified as a possible causative food product for diarrhea and vomiting. In conclusion, this study demonstrated that food distributors can implement post-marketing monitoring of the safety of food products purchased via the internet. PMID:27231884

  18. Development and Application of an Alert System to Detect Cases of Food Poisoning in Japan.

    Science.gov (United States)

    Maeyashiki, Akie; Akahane, Manabu; Sugiura, Hiroaki; Ohkusa, Yasushi; Okabe, Nobuhiko; Imamura, Tomoaki

    2016-01-01

    Recent public health concerns regarding commercial food products have increased the need to develop an automated method to detect food product-related health events. We developed and verified a method for the early detection of potentially harmful events caused by commercial food products. We collected data from daily internet-based questionnaires examining the presence or absence of symptoms and information about food purchased by the respondents. Using these data, we developed a method to detect possible health concerns regarding commercialized food products. To achieve this, we combined the signal detection method used in the reporting system of adverse effects of pharmaceutical products and the Early Aberration Reporting System (EARS) used by the United States Centers for Disease Control. Whiteleg shrimp (Litopenaeus vannamei), which had odds ratio and Odds(-) of 8.99 and 4.13, respectively, was identified as a possible causative food product for diarrhea and vomiting. In conclusion, this study demonstrated that food distributors can implement post-marketing monitoring of the safety of food products purchased via the internet. PMID:27231884

  19. When visual transients impair tactile change detection: a novel case of crossmodal change blindness?

    Science.gov (United States)

    Gallace, Alberto; Auvray, Malika; Tan, Hong Z; Spence, Charles

    2006-05-01

    The inability of people to detect changes between consecutively presented visual displays, when separated by a blank screen or distractor, is known as "change blindness". This phenomenon has recently been reported to occur within the auditory and tactile modalities as well. To date, however, only distractors presented within the same sensory modality as the change have been demonstrated to produce change blindness. In the present experiment, we studied whether tactile change blindness might also be elicited by the presentation of a visual mask. Participants made same versus different judgments regarding two successively presented displays composed of two to three vibrotactile stimuli. While change detection performance was near-perfect when the two displays were presented one directly after the other, participants failed to detect many of the changes between the tactile displays when they were separated by an empty temporal interval. Critically, performance deteriorated still further when the presentation of a local (i.e., a mudsplash) or global visual transient coincided with the onset of the second tactile pattern. Analysis of the results using signal detection theory revealed that this crossmodal effect reflected a genuine perceptual impairment. PMID:16480821

  20. Validating an Asthma Case Detection Instrument in a Head Start Sample

    Science.gov (United States)

    Bonner, Sebastian; Matte, Thomas; Rubin, Mitchell; Sheares, Beverley J.; Fagan, Joanne K.; Evans, David; Mellins, Robert B.

    2006-01-01

    Although specific tests screen children in preschool programs for vision, hearing, and dental conditions, there are no published validated instruments to detect preschool-age children with asthma, one of the most common pediatric chronic conditions affecting children in economically disadvantaged communities of color. As part of an asthma…

  1. A case of multiple hepatic abscesses detected by CT scan in the patient with acute lymphoblastic leukemia

    International Nuclear Information System (INIS)

    A 34 years old man admitted to a hospital on 21 Feb. 1983 and was diagnosed acute lymphoblastic leukemia. A hematological complete remission was achieved by combination therapy of vincristine, prednisolone and L-asparaginase. However, he had complaining of high fever and right hypochondralgia since early in Apr. 1983, and it was revealed that elevation of right diaphragm on chest X-ray. Therefore, he was also given several antibiotics (CPZ, TOB, LMOX, PIPC, LCM, AMK, MINO and GM) for complication of probable liver abscess. Remittent fever was persisted in spite of as mentioned above various antibiotics. The multiple hepatic abscesses were found by CT scan of the mid-abdomen as the low density lesions, but bacterial cultures detected no any pathogens. His complaining of remittent fever and right hypochondralgia were improved by treated with Miconazole during about one month, and decreasing in size and number of multiple hepatic abscesses were found by CT scan. Though we could not determined clearly, but suspected that, multiple hepatic abscesses were due to fungus infection, by reason of therapeutic result. Regarding the complication of hepatic abscesses with leukemia, 5 cases have been reported in Japan, and one case out of 5 cases were detected by CT scan. We thought that CT scan were useful procedure for a early diagnosis of hepatic abscesses. In recently, the patient has continued of complete remission hematologically. (author)

  2. Radiation Detection Scenario Analysis Toolbox (RADSAT) Test Case Implementation Final Report

    International Nuclear Information System (INIS)

    Final report for the project. This project was designed to demonstrate the use of the Radiation Detection Scenario Analysis Toolbox (RADSAT) radiation detection transport modeling package (developed in a previous NA-22 project) for specific radiation detection scenarios important to proliferation detection. This project was designed to demonstrate the use of the Radiation Detection Scenario Analysis Toolbox (RADSAT) radiation detection transport modeling package (developed in a previous NA-22 project) for specific radiation detection scenarios important to proliferation detection. RADSAT is founded on a 3-dimensional deterministic radiation transport solver capable of efficiently computing the radiation field at all points in complex, large-scale problems (e.g. buildings). These results are then coupled to a Monte Carlo detector response simulator. For this project Pacific Northwest National Laboratory (PNNL) staff applied RADSAT to two specific instruments and scenarios, in close collaboration with the developers of each technology. The first is a neutron-scatter camera for detection of concealed neutron-emitting sources developed at Sandia National Laboratories (SNL) and the second is a spent-fuel verification system for fuel assemblies in storage casks developed at Idaho National Laboratory (INL). To simulate detector responses, RADSAT uses a source modified version of Monte Carlo N-Particle Version 5 (MCNP5), which does not produce all of the information required to produce images for the scatter camera system. SNL models the scatter camera with Monte Carlo N-Particle - Politecnico di Milano (MCNP-PoliMi), which utilizes more accurate neutron elastic scattering physics and secondary gamma-ray production essential for modeling time-dependent events in multiple detectors. Therefore, RADSAT currently will not work for generating images for the scatter camera. However, it was demonstrated that RADSAT calculated the correct individual detector response, which

  3. Relationship between PSA kinetics and [18F]fluorocholine PET/CT detection rates of recurrence in patients with prostate cancer after total prostatectomy

    International Nuclear Information System (INIS)

    The aim of the present study was to identify prostate-specific antigen (PSA) threshold levels, as well as PSA velocity, progression rate and doubling time in relation to the detectability and localization of recurrent lesions with [18F]fluorocholine (FC) PET/CT in patients after radical prostatectomy. The study group comprised 82 consecutive patients with biochemical relapse after radical prostatectomy. PSA levels measured at the time of imaging were correlated with the FC PET/CT detection rates in the entire group with PSA velocity (in 48 patients), with PSA doubling time (in 47 patients) and with PSA progression (in 29 patients). FC PET/CT detected recurrent lesions in 51 of the 82 patients (62%). The median PSA value was significantly higher in PET-positive than in PET-negative patients (4.3 ng/ml vs. 1.0 ng/ml; p < 0.01). The optimal PSA threshold from ROC analysis for the detection of recurrent prostate cancer lesions was 1.74 ng/ml (AUC 0.818, 82% sensitivity, 74% specificity). Significant differences between PET-positive and PET-negative patients were found for median PSA velocity (6.4 vs. 1.1 ng/ml per year; p < 0.01) and PSA progression (5.0 vs. 0.3 ng/ml per year, p < 0.01) with corresponding optimal thresholds of 1.27 ng/ml per year and 1.28 ng/ml per year, respectively. The PSA doubling time suggested a threshold of 3.2 months, but this just failed to reach statistical significance (p = 0.071). In a study cohort of patients with biochemical recurrence of prostate cancer after radical prostatectomy there emerged clear PSA thresholds for the presence of FC PET/CT-detectable lesions. (orig.)

  4. 96例 Rh 血型抗体检测及分析%Detection and analysis on 96 cases of Rh blood group antibody

    Institute of Scientific and Technical Information of China (English)

    方晓蕾; 梅礼军; 刘锋; 张杰; 禹梅; 陈蕾

    2015-01-01

    Objective To analyze the positive rate of specific distribution characteristics in Rh blood group antibody,analyze the clinical significance of Rh blood group antibody and rules.Methods The micro column gel anti globulin technique was used to screen and identify irregular red blood cell antibodies,for patients with Rh blood group antibody,monoclonal anti-D,anti-C,anti-c, anti-E,anti-e were used to identify Rh blood group antigen to confirm the accuracy of detection.The antibody titer,Ig-type and 37℃ reactive were used to determine its clinical significance.Through asking pregnancy history,history of blood transfusion,under-standing whether the same specificity of the antibody in maternal plasma if the patient was newborn,the causes of antibody were an-alyzed.Results In 109 000 patients,Rh blood group antibodies were detected in 96 cases,the positive rate was 0.088%,which has a history of pregnancy in 68 cases,5 cases had history of blood transfusion,both pregnancy history and history of blood transfusion in 6 cases,1 7 cases of neonatal maternally derived antibody.Antibody specificity:65 cases of anti-E(67.710%),12 cases of anti-cE (12.500%),8 cases of anti-D (8.330%),7 cases of anti-c(7.291%),2 cases of anti-C (2.083%),2 cases of anti-e(2.083%).96 cases of Rh blood group antibodies were IgG or IgG+IgM class,37 ℃ reaction could be with the corresponding antigen of red blood cell,antibody titer between 4-2 048.Conclusion Anti-D detection rate shows a trend of gradually decreasing.In Rh blood group antibody detection,anti-E and anti-cE account for an absolute majority.Alloimmune caused by pregnancies and blood transfusion is the main reason of Rh blood group antibody production from Rh blood group antibody.Neonatal maternal passive getisa Rh-HDN is the main pathogenic antibody.%目的:调查 Rh血型抗体的检出率及其特异性分布特点,分析 Rh血型抗体的临床意义及产生规律。方法采用微柱凝胶抗球蛋白技术筛查和鉴定红细

  5. Wayne Manufacturing: A Teaching Case on the Detection of Misappropriation of Assets

    Science.gov (United States)

    Orchard, Lou X.; Decker, Jeffrey L.; Kizirian, Tim

    2007-01-01

    This paper is a teaching case intended for use in an undergraduate auditing or fraud examination course. Students are introduced to Wayne Manufacturing, a medium-sized firm in the Midwestern U.S.A. that manufactures parts for companies such as General Motors (GM) and Ford. Wayne Manufacturing has some conditions present that put it at risk for…

  6. Debris Disks in Aggregate: Using Hubble Space Telescope Coronagraphic Imagery to Understand the Scattered-Light Disk Detection Rate

    Science.gov (United States)

    Grady, Carol A.

    2011-01-01

    Despite more than a decade of coronagraphic imaging of debris disk candidate stars, only 16 have been imaged in scattered light. Since imaged disks provide our best insight into processes which sculpt disks, and can provide signposts of the presence of giant planets at distances which would elude radial velocity and transit surveys, we need to understand under what conditions we detect the disks in scattered light, how these disks differ from the majority of debris disks, and how to increase the yield of disks which are imaged with 0.1" angular resolution. In this talk, I will review what we have learned from a shallow HSTINICMOS NIR survey of debris disks, and present first results from our on-going HST /STIS optical imaging of bright scattered-light disks.

  7. Does the Use of Intraoperative Breast Sizers Increase Complication Rates in Primary Breast Augmentation? A Retrospective Analysis of 416 Consecutive Cases in a Single Institution

    OpenAIRE

    Lee Seng Khoo; Radwanski, Henrique N.; Vasco Senna-Fernandes; Nsingi Nsosolo Antônio; Leonardo Luiz Fernandes Fellet; Ivo Pitanguy

    2016-01-01

    Background. Is the use of intraoperative breast sizers beneficial for plastic surgeons or do they result in higher complication rates? Methods. This is a retrospective study of 416 consecutive cases of primary breast augmentation with silicone implants at the Plastic Surgery Service of Professor Ivo Pitanguy at the 38th Infirmary Santa Casa Misericórdia Hospital, Rio De Janeiro, from January 2011 to March 2014. 212 cases (51%) were carried out with use of intraoperative breast sizers with 204...

  8. Empirical Bayesian Method for the Estimation of Literacy Rate at Sub-district Level Case Study: Sumenep District of East Java Province

    OpenAIRE

    A.Tuti Rumiati; Khairil Anwar Notodiputro; Kusman Sadik; Wayan Mangku, I.

    2012-01-01

    This paper discusses Bayesian Method of Small Area Estimation (SAE) based on Binomial response variable. SAE method being developed to estimate parameter in small area due to insufficiency of sample. The case study is literacy rate estimation at sub-district level in Sumenep district, East Java Province. Literacy rate is measured by proportion of people who are able to read and write, from the population of 10 year-old or more. In the case study we used Social Economic Survey (Susenas)data co...

  9. Applying Hotspot Detection Methods in Forestry: A Case Study of Chestnut Oak Regeneration

    Directory of Open Access Journals (Sweden)

    Songlin Fei

    2010-01-01

    Full Text Available Hotspot detection has been widely adopted in health sciences for disease surveillance, but rarely in natural resource disciplines. In this paper, two spatial scan statistics (SaTScan and ClusterSeer and a nonspatial classification and regression trees method were evaluated as techniques for identifying chestnut oak (Quercus Montana regeneration hotspots among 50 mixed-oak stands in the central Appalachian region of the eastern United States. Hotspots defined by the three methods had a moderate level of conformity and revealed similar chestnut oak regeneration site affinity. Chestnut oak regeneration hotspots were positively associated with the abundance of chestnut oak trees in the overstory and a moderate cover of heather species (Vaccinium and Gaylussacia spp. but were negatively associated with the abundance of hayscented fern (Dennstaedtia punctilobula and mountain laurel (Kalmia latiforia. In general, hotspot detection is a viable tool for assisting natural resource managers with identifying areas possessing significantly high or low tree regeneration.

  10. Decision tree learning for detecting turning points in business process orientation: a case of Croatian companies

    Directory of Open Access Journals (Sweden)

    Ljubica Milanović Glavan

    2015-03-01

    Full Text Available Companies worldwide are embracing Business Process Orientation (BPO in order to improve their overall performance. This paper presents research results on key turning points in BPO maturity implementation efforts. A key turning point is defined as a component of business process maturity that leads to the establishment and expansion of other factors that move the organization to the next maturity level. Over the past few years, different methodologies for analyzing maturity state of BPO have been developed. The purpose of this paper is to investigate the possibility of using data mining methods in detecting key turning points in BPO. Based on survey results obtained in 2013, the selected data mining technique of classification and regression trees (C&RT was used to detect key turning points in Croatian companies. These findings present invaluable guidelines for any business that strives to achieve more efficient business processes.

  11. Information Design for “Weak Signal” detection and processing in Economic Intelligence: A case study on Health resources

    Directory of Open Access Journals (Sweden)

    Sahbi Sidhom

    2011-12-01

    Full Text Available The topics of this research cover all phases of “Information Design” applied to detect and profit from weak signals in economic intelligence (EI or business intelligence (BI. The field of the information design (ID applies to the process of translating complex, unorganized or unstructured data into valuable and meaningful information. ID practice requires an interdisciplinary approach, which combines skills in graphic design (writing, analysis processing and editing, human performances technology and human factors. Applied in the context of information system, it allows end-users to easily detect implicit topics known as “weak signals” (WS. In our approach to implement the ID, the processes cover the development of a knowledge management (KM process in the context of EI. A case study concerning information monitoring health resources is presented using ID processes to outline weak signals. Both French and American bibliographic databases were applied to make the connection to multilingual concepts in the health watch process.

  12. Non-target activity detection by post-radioembolization yttrium-90 PET/CT: Image assessment technique and case examples

    Directory of Open Access Journals (Sweden)

    Yung Hsiang eKao

    2014-02-01

    Full Text Available High-resolution yttrium-90 (90Y imaging of post-radioembolization microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT scanners that have time-of-flight capability. However, reconstructed 90Y PET/CT images have high background noise, making non-target activity detection technically challenging. This educational article describes our image assessment technique for non-target activity detection by 90Y PET/CT which qualitatively overcomes the problem of background noise. We present selected case examples of non-target activity in untargeted liver, stomach, gallbladder, chest wall and kidney, supported by angiography and 90Y bremsstrahlung single photon emission computed tomography with integrated computed tomography (SPECT/CT or technetium-99m macroaggregated albumin SPECT/CT.

  13. Detecting groan sources in drum brakes of commercial vehicles by TVA-FMEA: a case study:

    OpenAIRE

    Baynal, Kasim; Igdeli, Cengiz; Karabay, Sedat

    2013-01-01

    In this article, the strategy followed by an automobile company for detecting the root causes of groan complaints related to rear drum brakes in commercial vehicles is presented using data collected from the sold troubled vehicles and from new vehicles from the production line, as well as the drum-brake test rig at the laboratory. Drum brake groan is often very intense and can cause large numbers of customer complaints. During a groan noise event, vehicle structure and suspension components a...

  14. "Information Design" for "Weak Signal" detection and processing in Economic Intelligence: case study on Health resources

    OpenAIRE

    Sidhom, Sahbi; Lambert, Philippe

    2011-01-01

    Abstract -- The topics of this research cover all phases of the "Information Design" applied to detect and take profit on weak signals in economic intelligence (EI) (or BI: business intelligence). The field of the information design (ID) applies the process of translating complex, unorganized or unstructured data into valuable and meaningful information. The ID's practice requires an interdisciplinary approach which combines skills in graphic design - writing, analysis processing and editing ...

  15. Applying Hotspot Detection Methods in Forestry: A Case Study of Chestnut Oak Regeneration

    OpenAIRE

    Songlin Fei

    2010-01-01

    Hotspot detection has been widely adopted in health sciences for disease surveillance, but rarely in natural resource disciplines. In this paper, two spatial scan statistics (SaTScan and ClusterSeer) and a nonspatial classification and regression trees method were evaluated as techniques for identifying chestnut oak (Quercus Montana) regeneration hotspots among 50 mixed-oak stands in the central Appalachian region of the eastern United States. Hotspots defined by the three methods had a moder...

  16. Real-time remote detection and measurement for airborne imaging spectroscopy: a case study with methane

    OpenAIRE

    Thompson, D. R.; I. Leifer; Bovensmann, H.; Eastwood, M; M. Fladeland; C. Frankenberg; K. Gerilowski; Green, R. O.; S. Kratwurst; Krings, T; B. Luna; A. K. Thorpe

    2015-01-01

    Localized anthropogenic sources of atmospheric CH4 are highly uncertain and temporally variable. Airborne remote measurement is an effective method to detect and quantify these emissions. In a campaign context, the science yield can be dramatically increased by real-time retrievals that allow operators to coordinate multiple measurements of the most active areas. This can improve science outcomes for both single- and multiple-platform miss...

  17. USING GRACE TO DETECT GROUNDWATER STORAGE VARIATIONS: THE CASES OF CANNING BASIN AND GUARANI AQUIFER SYSTEM

    OpenAIRE

    Munier, Simon; Becker, Mélanie; Maisongrande, Philippe; Cazenave, Anny

    2012-01-01

    Monitoring groundwater resource is today challenging because of very scarce in situ measurement networks. Here we combine 7 years (2003-2009) of data from the Gravity Recovery and Climate Experiment (GRACE) satellite mission with outputs of four Land Surface Models to detect Groundwater Storage (GWS, water stored below the 1-10 m upper layers) variations. The method is applied on two great aquifers with different climatic regime and anthropogenic forcing: the Guarani Aquifer System (South Ame...

  18. DETECTING PLANETARY GEOCHEMICAL CYCLES ON EXOPLANETS: ATMOSPHERIC SIGNATURES AND THE CASE OF SO2

    International Nuclear Information System (INIS)

    We study the spectrum of a planetary atmosphere to derive detectable features in low resolution of different global geochemical cycles on exoplanets-using the sulfur cycle as our example. We derive low-resolution detectable features for first generation space- and ground-based telescopes as a first step in comparative planetology. We assume that the surfaces and atmospheres of terrestrial exoplanets (Earth-like and super-Earths) will most often be dominated by a specific geochemical cycle. Here we concentrate on the sulfur cycle driven by outgassing of SO2 and H2S followed by their transformation to other sulfur-bearing species, which is clearly distinguishable from the carbon cycle, which is driven by outgassing of CO2. Due to increased volcanism, the sulfur cycle is potentially the dominant global geochemical cycle on dry super-Earths with active tectonics. We calculate planetary emission, reflection, and transmission spectrum from 0.4 μm to 40 μm with high and low resolution to assess detectable features using current and Archean Earth models with varying SO2 and H2S concentrations to explore reducing and oxidizing habitable environments on rocky planets. We find specific spectral signatures that are observable with low resolution in a planetary atmosphere with high SO2 and H2S concentration. Therefore, first generation space- and ground-based telescopes can test our understanding of geochemical cycles on rocky planets and potentially distinguish planetary environments dominated by the carbon and sulfur cycles.

  19. Detection of Balamuthia mandrillaris DNA in the storage case of contact lenses in Germany.

    Science.gov (United States)

    Balczun, Carsten; Scheid, Patrick L

    2016-05-01

    Acanthamoeba spp. are frequently the etiological agents of a severe form of sight-threatening keratitis, called Acanthamoeba keratitis. The contact lens storage solution of a patient with keratitis of unknown genesis was screened using our diagnostic tools to detect potentially pathogenic free-living amoebae (FLA). Culture methods and a triplex quantitative real-time polymerase chain reaction (qPCR) targeting Acanthamoeba spp., Naegleria fowleri, and Balamuthia mandrillaris were used in context of this routine screening. While no amoebae were detected by culture, qPCR specifically detected DNA of B. mandrillaris. This FLA is known as the etiological agent of a fatal form of encephalitis in humans and other mammals, Balamuthia amoebic encephalitis (BAE). A fragment of the 18S rDNA gene was amplified from the sample and showed 99 % sequence identity to B. mandrillaris sequences from GenBank. To the best of our knowledge, this is the first report of B. mandrillaris found in association with contact lenses. Although no viable amoeba was obtained by culturing efforts, the verification of B. mandrillaris DNA in the contact lens storage solution demonstrates how easily this pathogen might come into close contact with humans. PMID:26965426

  20. The mass-loss rates of red supergiants at low metallicity: Detection of rotational CO emission from two red supergiants in the Large Magellanic Cloud

    CERN Document Server

    Matsuura, Mikako; Swinyard, Bruce; Yates, Jeremy; Royer, P; Barlow, M J; Boyer, Martha; Decin, L; Khouri, Theo; Meixner, Margaret; van Loon, Jacco Th; Woods, Paul M

    2016-01-01

    Using the PACS and SPIRE spectrometers on-board the Herschel Space Observatory, we obtained spectra of two red supergiants (RSGs) in the Large Magellanic Cloud (LMC). Multiple rotational CO emission lines (J=6-5 to 15-14) and 15 H2O lines were detected from IRAS 05280-6910, and one CO line was detected from WOH G64. This is the first time CO rotational lines have been detected from evolved stars in the LMC. Their CO line intensities are as strong as those of the Galactic RSG, VY CMa. Modelling the CO lines and the spectral energy distribution results in an estimated mass-loss rate for IRAS 05280-6910 of 3x10^-4 Msun per yr. The model assumes a gas-to-dust ratio and a CO-to-H2 abundance ratio is estimated from the Galactic values scaled by the LMC metallicity ([Fe/H]~-0.3), i.e., that the CO-to-dust ratio is constant for Galactic and LMC metallicities within the uncertainties of the model. The key factor determining the CO line intensities and the mass-loss rate found to be the stellar luminosity.