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Sample records for cart mortalidad hospitalaria

  1. Aproximación a la metodología basada en árboles de decisión (CART: Mortalidad hospitalaria del infarto agudo de miocardio Approach to the methodology of classification and regression trees

    Directory of Open Access Journals (Sweden)

    Javier Trujillano

    2008-02-01

    Full Text Available Objetivo: : Realizar una aproximación a la metodología de árboles de decisión tipo CART (Classification and Regression Trees desarrollando un modelo para calcular la probabilidad de muerte hospitalaria en infarto agudo de miocardio (IAM. Método: Se utiliza el conjunto mínimo básico de datos al alta hospitalaria (CMBD de Andalucía, Cataluña, Madrid y País Vasco de los años 2001 y 2002, que incluye los casos con IAM como diagnóstico principal. Los 33.203 pacientes se dividen aleatoriamente (70 y 30 % en grupo de desarrollo (GD = 23.277 y grupo de validación (GV = 9.926. Como CART se utiliza un modelo inductivo basado en el algoritmo de Breiman, con análisis de sensibilidad mediante el índice de Gini y sistema de validación cruzada. Se compara con un modelo de regresión logística (RL y una red neuronal artificial (RNA (multilayer perceptron. Los modelos desarrollados se contrastan en el GV y sus propiedades se comparan con el área bajo la curva ROC (ABC (intervalo de confianza del 95%. Resultados: En el GD el CART con ABC = 0,85 (0,86-0,88, RL 0,87 (0,86-0,88 y RNA 0,85 (0,85-0,86. En el GV el CART con ABC = 0,85 (0,85-0,88, RL 0,86 (0,85-0,88 y RNA 0,84 (0,83-0,86. Conclusiones: Los 3 modelos obtienen resultados similares en su capacidad de discriminación. El modelo CART ofrece como ventaja su simplicidad de uso y de interpretación, ya que las reglas de decisión que generan pueden aplicarse sin necesidad de procesos matemáticos.Objective: To provide an overview of decision trees based on CART (Classification and Regression Trees methodology. As an example, we developed a CART model intended to estimate the probability of intrahospital death from acute myocardial infarction (AMI. Method: We employed the minimum data set (MDS of Andalusia, Catalonia, Madrid and the Basque Country (2001-2002, which included 33,203 patients with a diagnosis of AMI. The 33,203 patients were randomly divided (70% and 30% into the development (DS

  2. Atención prenatal y mortalidad materna hospitalaria en Tijuana, Baja California

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    María Rode Gonzaga-Soriano; Abraham Zonana-Nacach; María Cecilia Anzaldo-Campos; Asbeidi Olazarán-Gutiérrez

    2014-01-01

    Objetivo. Describir la atención médica prenatal recibida en mujeres con mortalidad materna hospitalaria en el IMSS durante 2005-2012 en Tijuana, Baja California, México.Material y métodos. La información se obtuvo de los archivos de los Comités de Mortalidad Materna y revisión del expediente. Resultados. Hubo 44 muertes maternas (MM). Treinta (68%) asistieron a atención prenatal (AP), el promedio de citas fue de 3.8 y 18 (41%) tuvieron una AP adecuada ( 5 citas). Seis (14%) mujeres no...

  3. Procedimiento de Bentall en la enfermedad aneurismática de la aorta ascendente: mortalidad hospitalaria

    OpenAIRE

    2010-01-01

    Introducción: La enfermedad aneurismática de la aorta ascendente (EAAA) se caracteriza por su baja frecuencia, comportamiento heterogéneo, riesgo de rotura y disección, que conllevan elevada mortalidad, por lo que la cirugía electiva es fundamental. Se han desarrollado diversos procedimientos quirúrgicos, considerándose la técnica de Bentall el estándar de referencia. Se describe la mortalidad hospitalaria de la EAAA tratada quirúrgicamente mediante el procedimiento de Bentall. Material y mét...

  4. Mortalidad materna en Guatemala: diferencias entre muerte hospitalaria y no hospitalaria Maternal mortality in Guatemala: differences between hospital and non-hospital deaths

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    Ana Marina Tzul

    2006-06-01

    Full Text Available OBJETIVO: Estimar la asociación entre características obstétricas, sociodemográficas y factores de riesgo relacionados con la mortalidad materna hospitalaria y no hospitalaria en Guatemala durante el año 2000 MATERIAL Y MÉTODOS: Se realizó un estudio epidemiológico transversal con 649 casos de muertes maternas (MM ocurridas en la República de Guatemala durante el año 2000, en el que se compararon las características de las muertes maternas hospitalarias y no hospitalarias RESULTADOS: De 649 MM registradas, 270 (41.6% se clasificaron como MM hospitalarias y 379 (58.4% como MM no hospitalarias. La mayor proporción de muertes ocurrió en mujeres mayores de 35 años de edad (29.28%, indígenas (65.49%, casadas o unidas (87.83%, con ocupación no remunerada (94.78%, sin educación (66.56%. El riesgo de MM no hospitalaria fue mayor en mujeres del grupo indígena (RM= 3.4; IC95% 2.8-5.3, con ocupación no remunerada (RM= 8.95; IC95% 1.7-46.4, bajo nivel escolar (RM= 1.96; IC95% 1.0-3.8, y hemorragia como causa básica de muerte (RM= 4.28; IC95% 2.3-7.9 CONCLUSIONES: De los 679 casos de MM ocurridas en Guatemala en el año 2000, 58% correspondió a MM no hospitalarias, lo que puede estar relacionado con el hecho de que una alta proporción de la población habita en áreas rurales o de alta marginalidad, además de aspectos culturales (mayoría indígena que dificultan la accesibilidad a los servicios de salud. Los resultados presentados pueden servir de orientación para determinar estrategias de intervención que prevengan la mortalidad materna en los ámbitos hospitalario y extrahospitalario, en Guatemala.OBJECTIVE:To estimate the association between obstetric and socio-demographic characteristics and risk factors related to intra- and extra-hospital maternal mortality in Guatemala during the year 2000 MATERIALS AND METHODS: A cross-sectional epidemiologic study was carried out in 649 maternal mortality (MM cases that occurred in

  5. Aplicación de las redes neuronales artificiales para la estratificación de riesgo de mortalidad hospitalaria

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    Trujillano J.

    2003-01-01

    Full Text Available Objetivo: Comparar la capacidad de predicción de mortalidad hospitalaria de una red neuronal artificial (RNA con el Acute Physiology and Chronic Health Evaluation II (APACHE II y la regresión logística (RL, y comparar la asignación de probabilidades entre los distintos modelos. Método: Se recogen de forma prospectiva las variables necesarias para el cálculo del APACHE II. Disponemos de 1.146 pacientes asignándose aleatoriamente (70 y 30% al grupo de Desarrollo (800 y al de Validación (346. Con las mismas variables se genera un modelo de RL y de RNA (perceptrón de 3 capas entrenado por algoritmo de backpropagation con remuestreo bootstrap y con 9 nodos en la capa oculta en el grupo de desarrollo. Se comparan los tres modelos en función de los criterios de discriminación con el área bajo la curva ROC (ABC [IC del 95%] y de calibración con el test de Hosmer-Lemeshow C (HLC. Las diferencias entre las probabilidades se valoran con el test de Bland-Altman. Resultados: En el grupo de validación, el APACHE II con ABC de 0,79 (0,75-0,84 y HLC de 11 (p = 0,329; modelo RL, ABC de 0,81 (0,76-0,85 y HLC de 29 (p = 0,0001, y en RNA, ABC de 0,82 (0,77-0,86 y HLC de 10 (p = 0,404. Los pacientes con mayores diferencias en la asignación de probabilidad entre RL y RN (8% del total son pacientes con problemas neurológicos. Los peores resultados se obtienen en los pacientes traumáticos (ABC inferior a 0,75 en todos los modelos. En los pacientes respiratorios, la RNA alcanza los mejores resultados (ABC = 0,87 [0,78-0,91]. Conclusiones: Una RNA es capaz de estratificar el riesgo de mortalidad hospitalaria utilizando las variables del sistema APACHE II. La RNA consigue mejores resultados frente a RL, sin alcanzar significación, ya que no trabaja con restricciones lineales ni de independencia de variables, con una diferente asignación de probabilidad individual entre los modelos.

  6. In-hospital mortality and the Glasgow Coma Scale in the first 72 hours after traumatic brain injury Escala de Coma de Glasgow en las primeras 72 horas postrauma encefalocraneano y mortalidad hospitalaria Escala de Coma de Glasgow nas primeiras 72 horas após trauma cranioencefálico e mortalidade hospitalar

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    Cristina Helena Costanti Settervall

    2011-12-01

    Full Text Available This study verifies and compares the performance of three different scores obtained in the Glasgow Coma Scale (GCS in the first 72 hours post trauma in predicting in-hospital mortality. The studied scores included those obtained after initial care was provided at the hospital, and the worst and best scores obtained in the scale in the first 72 hours post trauma. The scale’s predictive ability was assessed by the Receiver Operator Characteristic (ROC curve. A total of 277 victims with different severity levels of blunt traumatic brain injuries were studied. The performance of the three scores that were analyzed to predict hospital mortality was moderate (0.74 to 0.79 and the areas under the curve did not present statistically significant differences. These findings suggest that any of the three studied scores can be applied in clinical practice to estimate the outcome of victims with blunt traumatic brain injuries, taking into consideration the instrument’s moderate discriminatory power.El estudio tiene como objetivos verificar y comparar el desempeño de puntajes de la Escala de Coma de Glasgow (ECGl observados en las primeras 72 horas postrauma para predecir la mortalidad hospitalaria. Los valores analizados fueron los puntajes obtenidos después de la atención inicial intra-hospitalaria, además de los peores y mejores resultados de la escala en las primeras 72 horas postrauma. La capacidad de predicción de los puntajes de la ECGl para el Estado Vital a la Salida Hospitalaria fue evaluada, utilizando la curva Reciever Operator Characteristic. Fueron estudiadas 277 víctimas, con trauma encefalocraneano contuso de diferentes gravedades. El desempeño de los puntajes de la ECGl para el estado vital a la salida hospitalaria fue moderado (0,74 a 0,79 y las áreas bajo la curva no presentaron diferencia significativa. Los resultados sugieren que cualquiera de los tres valores de la ECGl analizados pueden ser aplicados en la práctica cl

  7. Cancer incidence, hospital morbidity, and mortality in young adults in Brazil Incidencia, morbilidad hospitalaria y mortalidad por cáncer en adultos jóvenes en Brasil Incidência, morbidade hospitalar e mortalidade por câncer em adultos jovens no Brasil

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    Rosalina Jorge Koifman

    2013-05-01

    Full Text Available There are still relatively few studies in the world on cancer incidence and mortality in young adults. The current study aimed to explore cancer distribution in young adults in Brazil. A descriptive study was conducted on cancer incidence (selected State capitals, hospital morbidity, and mortality (Brazil and selected capitals in the 20-24-year age strata in 2000-2002, and trends in cancer mortality rates in Brazil in 1980-2008 in the same population. Testicular cancer was the principal anatomical site in young adult males; in young adult women, the main sites were thyroid, uterine cervix, and Hodgkin disease. Brain cancer was the principal cause of death from cancer in both sexes, and time trends in mortality showed an increase in mortality from brain cancer in men and from lymphocytic leukemia in both sexes. As a whole, the results show an epidemiological pattern of cancer in young adults with regional distribution characteristics.En el mundo todavía son relativamente pocos los estudios sobre la incidencia y mortalidad por cáncer en adultos jóvenes. El objetivo fue explorar la distribución de cáncer en adultos jóvenes en Brasil. Se realizó un estudio descriptivo de la incidencia (capitales seleccionadas, de la morbilidad hospitalaria y de la mortalidad (Brasil y capitales seleccionadas por cáncer a los 20-24 años, en el período de 2000-2002, y de la evolución de las tasas de mortalidad por cáncer en Brasil en el período de 1980-2008, en la misma población. El cáncer de testículo fue la principal localización anatómica en hombres, y las neoplasias de la glándula tiroides, del cuello de útero y la enfermedad de Hodgkin en las mujeres. El cáncer de encéfalo fue la principal causa de muerte por cáncer en ambos sexos y la tendencia temporal de la mortalidad muestra un aumento en la mortalidad por cáncer de encéfalo en hombres y por la leucemia linfoide en ambos sexos. En conjunto, los resultados presentados retratan un padr

  8. Aplicación de las redes neuronales artificiales para la estratificación de riesgo de mortalidad hospitalaria Application of artificial neural networks for risk stratification of hospital mortality

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    J. Trujillano

    2003-12-01

    Full Text Available Objetivo: Comparar la capacidad de predicción de mortalidad hospitalaria de una red neuronal artificial (RNA con el Acute Physiology and Chronic Health Evaluation II (APACHE II y la regresión logística (RL, y comparar la asignación de probabilidades entre los distintos modelos. Método: Se recogen de forma prospectiva las variables necesarias para el cálculo del APACHE II. Disponemos de 1.146 pacientes asignándose aleatoriamente (70 y 30% al grupo de Desarrollo (800 y al de Validación (346. Con las mismas variables se genera un modelo de RL y de RNA (perceptrón de 3 capas entrenado por algoritmo de backpropagation con remuestreo bootstrap y con 9 nodos en la capa oculta en el grupo de desarrollo. Se comparan los tres modelos en función de los criterios de discriminación con el área bajo la curva ROC (ABC [IC del 95%] y de calibración con el test de Hosmer-Lemeshow C (HLC. Las diferencias entre las probabilidades se valoran con el test de Bland-Altman. Resultados: En el grupo de validación, el APACHE II con ABC de 0,79 (0,75-0,84 y HLC de 11 (p = 0,329; modelo RL, ABC de 0,81 (0,76-0,85 y HLC de 29 (p = 0,0001, y en RNA, ABC de 0,82 (0,77-0,86 y HLC de 10 (p = 0,404. Los pacientes con mayores diferencias en la asignación de probabilidad entre RL y RN (8% del total son pacientes con problemas neurológicos. Los peores resultados se obtienen en los pacientes traumáticos (ABC inferior a 0,75 en todos los modelos. En los pacientes respiratorios, la RNA alcanza los mejores resultados (ABC = 0,87 [0,78-0,91]. Conclusiones: Una RNA es capaz de estratificar el riesgo de mortalidad hospitalaria utilizando las variables del sistema APACHE II. La RNA consigue mejores resultados frente a RL, sin alcanzar significación, ya que no trabaja con restricciones lineales ni de independencia de variables, con una diferente asignación de probabilidad individual entre los modelos.Objective: To compare the ability of an artificial neural network (ANN to

  9. Desnutrición hospitalaria Hospital hyponutrition

    OpenAIRE

    Waitzberg,D.L.; G. R. Ravacci; M. Raslan

    2011-01-01

    Identificar la desnutrición es fundamental en el ambiente hospitalario para evitar o minimizar la repercusión en la evolución clínica de los enfermos e la asociación con mayores complicaciones, mayor tiempo de estancia hospitalaria e incremento en la mortalidad, y eso está asociado a costos aumentados para la institución y la sociedad. Los objetivos dese estudio fueran descreer la epidemiologia de la desnutrición hospitalaria, los tipos de desnutrición, la respuesta orgánica al ayuno, la evol...

  10. Queimaduras em crianças e adolescentes: análise da morbidade hospitalar e mortalidade Quemaduras en niños y adolescentes: análisis de la morbilidad hospitalaria y de la mortalidad Burns in children and adolescents: hospital morbidity and mortality analysis

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    Christine Baccarat de Godoy Martins

    2007-12-01

    Full Text Available OBJETIVO: Analisar a incidência hospitalar e a mortalidade por queimadura em menores de 15 anos, residentes em Londrina, atendidos em pronto-socorro, internados ou que foram a óbito em 2001. MÉTODOS: Trata-se de estudo transversal e descritivo, cujos dados de morbidade foram obtidos nos serviços de emergência e internação dos cinco hospitais de Londrina e os de mortalidade no Núcleo de Informação em Mortalidade do município. Para análise e tratamento dos dados, utilizou-se o programa computacional Epi-Info - versão 6.0.d. RESULTADOS: Foram estudados 182 casos de menores de 15 anos vítimas de queimadura: 82,4% por substância quente / fonte de calor; 14,3% por exposição à fumaça / fogo / chama; 3,3% por exposição a corrente elétrica. Predominou o sexo masculino (56,6% e a idade de um ano (6,1 por 1000 crianças. A taxa de internação foi de 12,6%, ocorrendo um óbito. O período de internação foi de um a três dias em 56,5% dos casos. CONCLUSÕES: Os achados contribuem para ampliar o conhecimento epidemiológico de tais eventos, reforçando a necessidade da prevenção.OBJETIVO: Analizar la incidencia hospitalaria y la mortalidad por quemadura en menores de 15 años, residentes en Londrina, atendidos en el servicio de emergencia, internados o que murieron en el 2001. MÉTODOS: Se trata de un estudio transversal y descriptivo, cuyos datos de morbilidad fueron obtenidos en los servicios de emergencia e internamiento de los cinco hospitales de Londrina y los de mortalidad en el Núcleo de Información en Mortalidad del municipio. Para el análisis y tratamiento de los datos, se utilizó el programa Epi-Info - versión 6.0.d. RESULTADOS: Fueron estudiados 182 casos de menores de 15 años víctimas de quemadura: 82,4% por sustancia caliente / fuente de calor; 14,3% por exposición al humo/ fuego / llama; 3,3% por exposición a la corriente eléctrica. Predominó el sexo masculino (56,6% y la edad de un año (6,1 por 1,000 ni

  11. Desnutrición hospitalaria

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    D. L. Waitzberg

    Full Text Available Identificar la desnutrición es fundamental en el ambiente hospitalario para evitar o minimizar la repercusión en la evolución clínica de los enfermos e la asociación con mayores complicaciones, mayor tiempo de estancia hospitalaria e incremento en la mortalidad, y eso está asociado a costos aumentados para la institución y la sociedad. Los objetivos dese estudio fueran descreer la epidemiologia de la desnutrición hospitalaria, los tipos de desnutrición, la respuesta orgánica al ayuno, la evolución clínica del enfermo con desnutrición e las consecuencias de la desnutrición en las diferentes etapas de la vida, para tanto, realizamos una revisó sobre desnutrición hospitalaria. Encontramos que la prevalencia de desnutrición es elevada en el ambiente hospitalario, la desnutrición influencia factores genéticos, metabólicos y hormonales del organismo humano y conlleva a efectos perjudiciales desde el desarrollo fetal intrauterino hasta la vida adulta. Hay también diferentes tipos de desnutrición, siendo la diferenciación importante para decidir el mejor tratamiento. También, encontramos la desnutrición está relacionada con la inflamación. Cuando la inflamación es crónica y de grado leve a moderado (como el fallo de un órgano, cáncer pancreático, obesidad, artritis reumatoide o sarcopénica se puede utilizar el término "enfermedad crónica relacionada con de la desnutrición", y, cuando la inflamación es aguda y de grado severo (infección grave, quemaduras, trauma o lesión en la cabeza cerrada, el término "enfermedad aguda o lesiones relacionadas con la desnutrición" es preferido. Por último, el paciente con desnutrición tiene peor evolución clínica que el paciente que presenta un adecuado estado de nutrición.

  12. The impact of malnutrition on morbidity, mortality and length of hospital stay in trauma patients El impacto de la malnutrición sobre la morbilidad, mortalidad y duración de la estancia hospitalaria en pacientes traumatológicos

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    M. E. Goiburu

    2006-10-01

    prospectiva a 161 pacientes adultos ingresados en las unidades de cuidados intensivos (UCI, cirugía general, cirugía maxilofacial y traumatología, en el Centro de Emergencias Médicas de Asunción, Paraguay, desde marzo de 2002 a marzo de 2004, a su ingreso, mediante el Subjective Global Assessment (SGA. Se siguió a los pacientes para determinar la duración de la estancia hospitalaria, las complicaciones y la mortalidad intra-hospitalaria. Resultados: en la unidad traumatológica, la edad media de los pacientes fue 27 años (14-92 y el 94% eran varones. La mayoría era de origen rural (74%. Los sitios anatómicos lesionados con mayor frecuencia fueron: cabeza 25%, tórax 16,6%, miembros 15,4%, abdomen 14%. La puntuación mediana del Injury Severity Score (ISS fue 20 (1-39. En esta población de pacientes, 40% estaba malnutrida o en riesgo de malnutrición de acuerdo con el SGA. El análisis multivariado identificó los siguientes factores de riesgo de mortalidad: malnutrición según el SGA (p = 0,04, RR = 4 (1-15, y el ingreso en la UCI (p = 0,0001, RR = 53 (12-234. Los factores de riesgo de complicaciones fueron la malnutrición según el SGA (p = 0,003, RR = 2,9 (1,4-5,8 y el ISS mayor de 20 (p = 0,001, RR = 8,4 (2,3-29,9. Los factores de riesgo para la duración de la estancia fueron la malnutrición según el SGA (p = 0,01, RR = 2,3 (1,2-4,7 y el ISS mayor de 20 (p = 0,03, RR = 2,8 (1-7,3. Conclusiones: en las condiciones de estudio, la malnutrición es frecuente al ingreso de pacientes traumatológicos, y es un factor de riesgo independiente sobre la morbilidad, mortalidad y prolonga la duración de la hospitalización. Se deberían realizar esfuerzos para valorar rápidamente el estado nutritivo de estos pacientes y comenzar una intervención nutricional de forma precoz.

  13. [Bullock cart

    OpenAIRE

    Smithson, John Snowden, fl 1903

    2003-01-01

    Showing two bullocks pulling a covered cart along a street lined with stone buildings. Two boys can be seen watching in the foreground and a man is walking between the animals. Another man is walking on the far side of the road.

  14. Factores asociados a la muerte materna hospitalaria en el estado de Morelos, México

    OpenAIRE

    Bernardo Hernández; Minerva Romero; Jesús Chirinos; Ana Langer

    1994-01-01

    A través de este trabajo, se buscó conocer algunos factores relacionados con la mortalidad materna hospitalaria en el estado de Morelos, México. Se realizó un estudio de casos y controles. Los casos fueron todas las mujeres cuya muerte materna hospitalaria ocurrió en el estado de Morelos entre 1989-1991 (n=35); los controles fueron mujeres que, con las mismas complicaciones y atendidas en los mismos hospitales, sobrevivieron al embarazo (n=35). Los resultados señalan como factores protectores...

  15. Mortalidad intrahospitalaria por accidente cerebrovascular

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    Federico Rodríguez Lucci

    2013-08-01

    Full Text Available La mortalidad global por accidente cerebrovascular (ACV ha disminuido en las últimas tres décadas, probablemente debido a un mejor control de los factores de riesgo vascular. La mortalidad hospitalaria por ACV ha sido tradicionalmente estimada entre 6 y 14% en la mayoría de las series comunicadas. Sin embargo, los datos de ensayos clínicos recientes sugieren que esta cifra sería sustancialmente menor. Se revisaron datos de pacientes internados con diagnóstico de ACV del Banco de Datos de Stroke de FLENI y los registros institucionales de mortalidad entre los años 2000 y 2010. Los subtipos de ACV isquémicos se clasificaron según criterios TOAST y los ACV hemorrágicos en hematomas intrapanquimatosos, hemorragias subaracnoideas aneurismáticas, malformaciones arteriovenosas y otros hematomas intraparenquimatosos. Se analizaron 1514 pacientes, 1079 (71% con ACV isquémico (grandes vasos 39%, cardioembólicos 27%, lacunares 9%, etiología indeterminada 14%, otras etiologías 11% y 435 (29% con ACV hemorrágico (intraparenquimatosos 27%, hemorragia subaracnoidea 30%, malformaciones arteriovenosas 25% y otros hematomas espontáneos 18%. Se registraron 38 muertes intrahospitalarias (17 ACV isquémicos y 21 ACV hemorrágicos, representando una mortalidad global del 2.5% (1.7% en ACV isquémicos y 4.8% en ACV hemorrágicos. No se registraron muertes asociadas al uso de fibrinolíticos endovenosos. La mortalidad intrahospitalaria en pacientes con ACV isquémico y hemorrágico en nuestro centro fue baja. El manejo en un centro dedicado a las enfermedades neurológicas y el enfoque multidisciplinario por personal médico y no médico entrenado en el cuidado de la enfermedad cerebrovascular podrían explicar, al menos en parte, estos resultados.

  16. [Two-wheeled cart

    OpenAIRE

    2003-01-01

    205 x 139 mm. A view showing a two-wheeled wooden cart being pulled by two bovine quadrupeds. A man is sitting in the cart and a European man is standing to the side watching. Photograph taken circa 1900.

  17. Prevalencia y factores asociados a desnutrición hospitalaria en un hospital general: Perú, 2012

    OpenAIRE

    L. E. Veramendi-Espinoza; J. H. Zafra-Tanaka; O. Salazar-Saavedra; J. E. Basilio-Flores; E. Millones-Sánchez; G. A. Pérez-Casquino; L. M. Quispe-Moore; M. E. Tapia-Vicente; D. I. Ticona-Rebagliati; N. B. Asato; L. Quispe-Calderón; H. J. Ruiz García; A. Chia-Gil; D. E. Rey-Rodríguez; B. T. Surichaqui

    2013-01-01

    Introducción: La desnutrición hospitalaria es un problema prevalente que genera mayor morbi-mortalidad, peor respuesta al tratamiento, mayor estancia y costo hospitalario. Objetivos: Determinar la prevalencia y factores asociados a desnutrición hospitalaria en un hospital general peruano. Métodos: Estudio analítico transversal de 211 pacientes en servicios de Medicina y Cirugía. Se analizó variables demográficas, clínicas e indicadores antropométricos. El análisis multivariado fue de regresió...

  18. Desnutrición hospitalaria Hospital hyponutrition

    Directory of Open Access Journals (Sweden)

    D. L. Waitzberg

    2011-04-01

    Full Text Available Identificar la desnutrición es fundamental en el ambiente hospitalario para evitar o minimizar la repercusión en la evolución clínica de los enfermos e la asociación con mayores complicaciones, mayor tiempo de estancia hospitalaria e incremento en la mortalidad, y eso está asociado a costos aumentados para la institución y la sociedad. Los objetivos dese estudio fueran descreer la epidemiologia de la desnutrición hospitalaria, los tipos de desnutrición, la respuesta orgánica al ayuno, la evolución clínica del enfermo con desnutrición e las consecuencias de la desnutrición en las diferentes etapas de la vida, para tanto, realizamos una revisó sobre desnutrición hospitalaria. Encontramos que la prevalencia de desnutrición es elevada en el ambiente hospitalario, la desnutrición influencia factores genéticos, metabólicos y hormonales del organismo humano y conlleva a efectos perjudiciales desde el desarrollo fetal intrauterino hasta la vida adulta. Hay también diferentes tipos de desnutrición, siendo la diferenciación importante para decidir el mejor tratamiento. También, encontramos la desnutrición está relacionada con la inflamación. Cuando la inflamación es crónica y de grado leve a moderado (como el fallo de un órgano, cáncer pancreático, obesidad, artritis reumatoide o sarcopénica se puede utilizar el término "enfermedad crónica relacionada con de la desnutrición", y, cuando la inflamación es aguda y de grado severo (infección grave, quemaduras, trauma o lesión en la cabeza cerrada, el término "enfermedad aguda o lesiones relacionadas con la desnutrición" es preferido. Por último, el paciente con desnutrición tiene peor evolución clínica que el paciente que presenta un adecuado estado de nutrición.Identifying hyponutrition is essential at the hospital setting to avoid or minimize the impact on the patients' clinical course and its association with more severe complications, longer hospital staying

  19. Emergency-Evacuation Cart

    Science.gov (United States)

    Fedor, Otto H.; Owens, Lester J.

    1988-01-01

    Proposed cart designed to remove injured worker from vicinity of hazardous chemical spill. Self-propelled cart enables rescuer to move victim of industrial accident quickly away from toxic, flammable, explosive, corrosive, carcinogenic, asphyxiating, or extremely cold liquids. Intended for use where too dangerous for ambulances and other vehicles to approach accident site. Constructed of high-strength tubing, rides on bicycle wheels with balloon tires. Rescuer steers cart with handle at rear. Estimated mass of fully equipped vehicle is 650 lb.

  20. Service Cart For Engines

    Science.gov (United States)

    Ng, Gim Shek

    1995-01-01

    Cart supports rear-mounted air-cooled engine from Volkswagen or Porsche automobile. One person removes, repairs, tests, and reinstalls engine of car, van, or home-built airplane. Consists of framework of wood, steel, and aluminum components supported by four wheels. Engine lifted from vehicle by hydraulic jack and gently lowered onto waiting cart. Jack removed from under engine. Rear of vehicle raised just enough that engine can be rolled out from under it. Cart easily supports 200-lb engine. Also used to hold transmission. With removable sheet-metal top, cart used as portable seat.

  1. Microbiological surface sampling cart

    Science.gov (United States)

    Wilkins, J. R.; Mills, S. M.

    1972-01-01

    Mobile sampling cart automatically swabs surfaces for the recovery of microorganisms. Unit operates without human involvement and provides for control of swabbing speed, rotation of cotton swab, and the pressure and angle applied to swab. Capability of reverse direction is also available. Sampling cart use is limited to flat surfaces.

  2. Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus)

    OpenAIRE

    2015-01-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide is implicated in the control of avian energy balance, however, the structure and expression of CART gene(s) remains largely unknown in birds. Here, we cloned and characterized two CART genes (named cCART1 and cCART2) in chickens. The cloned cCART1 is predicted to generate two bioactive peptides, cCART1(42-89) and cCART1(49-89), which share high amino acid sequence identity (94-98%) with their mammalian counterparts, while the novel ...

  3. Perfil nutricional de los adultos mayores en una unidad hospitalaria en Costa Rica

    OpenAIRE

    Isabel Barrientos Calvo; Fabián Madrigal-Leer

    2014-01-01

    La desnutrición es un estado en el cual existe una deficiencia de energía, proteínas y otros nutrientes, causando efectos adversos en la función corporal. Los estados de déficit nutricionales, se asocian con mayores complicaciones, mayor tiempo de estancia hospitalaria e incremento en la mortalidad. Objetivo: Describir el estado nutricional y las características de los pacientes valorados por el Grupo Clínico de Soporte Nutricional del Hospital Nacional de Geriatría y Gerontología. Metodologí...

  4. Cable-Dispensing Cart

    Science.gov (United States)

    Bredberg, Alan S.

    2003-01-01

    A versatile cable-dispensing cart can support as many as a few dozen reels of cable, wire, and/or rope. The cart can be adjusted to accommodate reels of various diameters and widths, and can be expanded, contracted, or otherwise reconfigured by use of easily installable and removable parts that can be carried onboard. Among these parts are dispensing rods and a cable guide that enables dispensing of cables without affecting the direction of pull. Individual reels can be mounted on or removed from the cart without affecting the other reels: this feature facilitates the replacement or reuse of partially depleted reels, thereby helping to reduce waste. Multiple cables, wires, or ropes can be dispensed simultaneously. For maneuverability, the cart is mounted on three wheels. Once it has been positioned, the cart is supported by rubber mounts for stability and for prevention of sliding or rolling during dispensing operations. The stability and safety of the cart are enhanced by a low-center-of-gravity design. The cart can readily be disassembled into smaller units for storage or shipping, then reassembled in the desired configuration at a job site.

  5. Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus).

    Science.gov (United States)

    Cai, Guoqing; Mo, Chunheng; Huang, Long; Li, Juan; Wang, Yajun

    2015-01-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide is implicated in the control of avian energy balance, however, the structure and expression of CART gene(s) remains largely unknown in birds. Here, we cloned and characterized two CART genes (named cCART1 and cCART2) in chickens. The cloned cCART1 is predicted to generate two bioactive peptides, cCART1(42-89) and cCART1(49-89), which share high amino acid sequence identity (94-98%) with their mammalian counterparts, while the novel cCART2 may produce a bioactive peptide cCART2(51-91) with 59% identity to cCART1. Interestingly, quantitative RT-PCR revealed that cCART1 is predominantly expressed in the anterior pituitary and less abundantly in the hypothalamus. In accordance with this finding, cCART1 peptide was easily detected in the anterior pituitary by Western blot, and its secretion from chick pituitaries incubated in vitro was enhanced by ionomycin and forskolin treatment, indicating that cCART1 is a novel peptide hormone produced by the anterior pituitary. Moreover, cCART1 mRNA expression in both the pituitary and hypothalamus is down-regulated by 48-h fasting, suggesting its expression is affected by energy status. Unlike cCART1, cCART2 is only weakly expressed in most tissues examined by RT-PCR, implying a less significant role of cCART2 in chickens. As in chickens, 2 or more CART genes, likely generated by gene and genome duplication event(s), were also identified in other non-mammalian vertebrate species including coelacanth. Collectively, the identification and characterization of CART genes in birds helps to uncover the roles of CART peptide(s) in vertebrates and provides clues to the evolutionary history of vertebrate CART genes.

  6. Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus)

    Science.gov (United States)

    Huang, Long; Li, Juan; Wang, Yajun

    2015-01-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide is implicated in the control of avian energy balance, however, the structure and expression of CART gene(s) remains largely unknown in birds. Here, we cloned and characterized two CART genes (named cCART1 and cCART2) in chickens. The cloned cCART1 is predicted to generate two bioactive peptides, cCART1(42-89) and cCART1(49-89), which share high amino acid sequence identity (94-98%) with their mammalian counterparts, while the novel cCART2 may produce a bioactive peptide cCART2(51-91) with 59% identity to cCART1. Interestingly, quantitative RT-PCR revealed that cCART1 is predominantly expressed in the anterior pituitary and less abundantly in the hypothalamus. In accordance with this finding, cCART1 peptide was easily detected in the anterior pituitary by Western blot, and its secretion from chick pituitaries incubated in vitro was enhanced by ionomycin and forskolin treatment, indicating that cCART1 is a novel peptide hormone produced by the anterior pituitary. Moreover, cCART1 mRNA expression in both the pituitary and hypothalamus is down-regulated by 48-h fasting, suggesting its expression is affected by energy status. Unlike cCART1, cCART2 is only weakly expressed in most tissues examined by RT-PCR, implying a less significant role of cCART2 in chickens. As in chickens, 2 or more CART genes, likely generated by gene and genome duplication event(s), were also identified in other non-mammalian vertebrate species including coelacanth. Collectively, the identification and characterization of CART genes in birds helps to uncover the roles of CART peptide(s) in vertebrates and provides clues to the evolutionary history of vertebrate CART genes. PMID:25992897

  7. Characterization of the Two CART Genes (CART1 and CART2 in Chickens (Gallus gallus.

    Directory of Open Access Journals (Sweden)

    Guoqing Cai

    Full Text Available Cocaine- and amphetamine-regulated transcript (CART peptide is implicated in the control of avian energy balance, however, the structure and expression of CART gene(s remains largely unknown in birds. Here, we cloned and characterized two CART genes (named cCART1 and cCART2 in chickens. The cloned cCART1 is predicted to generate two bioactive peptides, cCART1(42-89 and cCART1(49-89, which share high amino acid sequence identity (94-98% with their mammalian counterparts, while the novel cCART2 may produce a bioactive peptide cCART2(51-91 with 59% identity to cCART1. Interestingly, quantitative RT-PCR revealed that cCART1 is predominantly expressed in the anterior pituitary and less abundantly in the hypothalamus. In accordance with this finding, cCART1 peptide was easily detected in the anterior pituitary by Western blot, and its secretion from chick pituitaries incubated in vitro was enhanced by ionomycin and forskolin treatment, indicating that cCART1 is a novel peptide hormone produced by the anterior pituitary. Moreover, cCART1 mRNA expression in both the pituitary and hypothalamus is down-regulated by 48-h fasting, suggesting its expression is affected by energy status. Unlike cCART1, cCART2 is only weakly expressed in most tissues examined by RT-PCR, implying a less significant role of cCART2 in chickens. As in chickens, 2 or more CART genes, likely generated by gene and genome duplication event(s, were also identified in other non-mammalian vertebrate species including coelacanth. Collectively, the identification and characterization of CART genes in birds helps to uncover the roles of CART peptide(s in vertebrates and provides clues to the evolutionary history of vertebrate CART genes.

  8. Cartes hors texte

    OpenAIRE

    2013-01-01

    1 – Carte de la Martinique IRD-Bondy-LCA 2 – Carte de situation des Antilles IRD-Bondy-LCA 3 – Carte topo-climatique de la Martinique IRD-Bondy-LCA 4 – Banane et bananeraies en 1969 en Martinique IRD-Bondy-LCA 5 – Banane et bananeraies en 1980 en Martinique IRD-Bondy-LCA 6 – Les sols de Martinique IRD-Bondy-LCA 7 – Canne à sucre en 1969 et 1980 en Martinique IRD-Bondy-LCA

  9. Aplicación de variables bioquímicas y antropométricas en la predicción de la desnutrición hospitalaria

    OpenAIRE

    Herrera Castro, Patricia

    2016-01-01

    [ES]La desnutrición es la causa más frecuente de aumento de la morbi-mortalidad y uno de los principales problemas de salud en el mundo. Afecta de forma particular a un grupo de pacientes, los hospitalizados, donde la incapacidad de ingesta y la enfermedad son comunes. Esta entidad propia es denominada desnutrición hospitalaria (DH). La Desnutrición Hospitalaria está bien reconocida y documentada en la literatura mundial. A pesar de ser la enfermedad más prevalente en los hospitales,...

  10. Madeira. Bullock cart

    OpenAIRE

    Unknown

    2003-01-01

    229 x 175 mm. Showing two passengers seated in a characteristic Maderia bullock cart or sled, with two drivers standing beside the animals and two other figures seated on the steps in the background. Photograph taken in the 1880s.

  11. Jeux de cartes

    Directory of Open Access Journals (Sweden)

    Pierre GENTELLE

    1986-09-01

    Full Text Available Dans la grande tradition de la science-fiction et des lieux imaginaires traduits ici en «jeux» de cartes, l'auteur bouleverse quelques localisations au prix de mouvements tectoniques imprévus et en prévoit quelques conséquences.

  12. The lunar cart

    Science.gov (United States)

    Miller, G. C.

    1972-01-01

    Expanded experiment-carrying capability, to be used between the Apollo 11 capability and the lunar roving vehicle capability, was defined for the lunar surface crewmen. Methods used on earth to satisfy similar requirements were studied. A two-wheeled cart was built and tested to expected mission requirements and environments. The vehicle was used successfully on Apollo 14.

  13. Zen Cart, the Online Shopping Cart Platform

    OpenAIRE

    2007-01-01

    Tato bakalářská práce se zabývá open source platformou pro internetový obchod s názvem Zen Cart a konkrétně se zaměřuje na řešení systému objednávek z pohledu uživatele (administrátora). Část práce se věnuje hodnocení objednávek ve standardní instalaci. Dále se věnuje optimalizaci vyhledávání a rozšíření funkcí pro vícejazyčné obchody. V poslední části popisuje navržený a implementovaný plug-in umožňující export objednávek.

  14. Le logiciel FastCart

    OpenAIRE

    1986-01-01

    FastCart est un logiciel destiné à l'enseignement de la géographie. Il permet aux élèves de créer leurs propres documents d'études: histogrammes, cartes en hachures, cartes de classification de l'espace. Sa rapidité d'exécution et sa facilité d'utilisation en font un outil adapté aux exigences des enseignants.

  15. Fan Cart: The Next Generation

    Science.gov (United States)

    Lamore, Brian

    2016-10-01

    For years the fan cart has provided physics students with an excellent resource for exploring fundamental mechanics concepts such as acceleration, Newton's laws, impulse, momentum, work-energy, and energy conversions. The Physics Teacher has even seen some excellent do-it-yourself (DIY) fan carts and activities. If you are interested in developing the `E' portion of your and your students' STEM (science, technology, engineering, and math) skills, one way to accomplish this is to revisit the DIY fan cart. In this article I share a design of a new edition of the DIY fan cart and some ideas for incorporating the engineering design process into your high school curriculum.

  16. Variable selection through CART

    CERN Document Server

    Sauvé, Marie

    2011-01-01

    This paper deals with variable selection in the regression and binary classification frameworks. It proposes an automatic and exhaustive procedure which relies on the use of the CART algorithm and on model selection via penalization. This work, of theoretical nature, aims at determining adequate penalties, i.e. penalties which allow to get oracle type inequalities justifying the performance of the proposed procedure. Since the exhaustive procedure can not be executed when the number of variables is too big, a more practical procedure is also proposed and still theoretically validated. A simulation study completes the theoretical results.

  17. Fan Cart: The Next Generation

    Science.gov (United States)

    Lamore, Brian

    2016-01-01

    For years the fan cart has provided physics students with an excellent resource for exploring fundamental mechanics concepts such as acceleration, Newton's laws, impulse, momentum, work-energy, and energy conversions. "The Physics Teacher" has even seen some excellent do-it-yourself (DIY) fan carts and activities. If you are interested…

  18. Controlling errors in unidosis carts

    Directory of Open Access Journals (Sweden)

    Inmaculada Díaz Fernández

    2010-01-01

    Full Text Available Objective: To identify errors in the unidosis system carts. Method: For two months, the Pharmacy Service controlled medication either returned or missing from the unidosis carts both in the pharmacy and in the wards. Results: Uncorrected unidosis carts show a 0.9% of medication errors (264 versus 0.6% (154 which appeared in unidosis carts previously revised. In carts not revised, the error is 70.83% and mainly caused when setting up unidosis carts. The rest are due to a lack of stock or unavailability (21.6%, errors in the transcription of medical orders (6.81% or that the boxes had not been emptied previously (0.76%. The errors found in the units correspond to errors in the transcription of the treatment (3.46%, non-receipt of the unidosis copy (23.14%, the patient did not take the medication (14.36%or was discharged without medication (12.77%, was not provided by nurses (14.09%, was withdrawn from the stocks of the unit (14.62%, and errors of the pharmacy service (17.56% . Conclusions: It is concluded the need to redress unidosis carts and a computerized prescription system to avoid errors in transcription.Discussion: A high percentage of medication errors is caused by human error. If unidosis carts are overlooked before sent to hospitalization units, the error diminishes to 0.3%.

  19. Factores de riesgo y mortalidad a corto plazo en pacientes con peritonitis secundaria y terciaria

    OpenAIRE

    Ballús Noguera, Josep

    2016-01-01

    Antecedentes: Los pacientes quirúrgicos críticos tienen un alto riesgo de padecer efectos adversos graves como consecuencia de una infección intraabdominal grave , con ello una prolongación de su estancia en UCI. El objetivo de nuestro estudio fue identificar los factores de riesgo de mortalidad hospitalaria de los pacientes ingresados en la UCI que sufren peritonitis complicadas, junto con los factores de riesgo asociados a desarrollar una peritonitis terciaria. La Infección del sitio quirúr...

  20. A la Carte Community

    DEFF Research Database (Denmark)

    Gundelach, Peter; Brincker, Benedikte

    2010-01-01

    The exchange of open source software is a phenomenon that is becoming in- creasingly significant to IT users. This article presents the results of a study of the TYPO3 community, a community related to an open source CMS software. The article explores the community, identity and values of TYPO3...... and shows that there are high levels of virtual as well as face-to-face interaction among the members. The participants feel that they belong to the community and many also feel that they are recognised as part of the community. However, the members do not share common values neither in relation to software...... pro- duction nor generally. Instead, they stress that you are free to choose your own values. Against this background, the authors introduce the notion of an ‘a la carte community', i.e. a community where individuals pick and choose their degree of participation and integra- tion into the community...

  1. Cart with oxen

    OpenAIRE

    2016-01-01

    A black and white photograph showing two carts and two oxen. One of the oxen is standing and the other is resting on the ground - Μαυρόασπρη φωτογραφία που δείχνει δύο καρότσια και δύο βόδια. Το ένα βόδι στέκεται και το άλλο ξαπλώνει στο έδαφος.

  2. The rain-powered cart

    Science.gov (United States)

    Mungan, Carl E.; Lipscombe, Trevor C.

    2016-09-01

    A frictionless cart in the shape of a right triangle (with the vertical side forward) is elastically impacted by vertically falling raindrops. The speed of the cart as a function of time can be analytically deduced as an exercise in the use of trigonometric and hyperbolic functions. A characteristic time defines the approach to a terminal speed which is a sizeable fraction of the speed of the rain. The treatment is accessible to a student in a calculus-based mechanics course.

  3. FPC conditioning cart at BNL

    Energy Technology Data Exchange (ETDEWEB)

    Xu, W.; Ben-Zvi, I.; Altinbas, F.Z.; Belomestnykh, S.; Burrill, A.; Cole, M.; Deonarine, J.; Jamilkowski, J.; Kayran, D.; Laloudakis, N.; Masi Jr, L.; McIntyre, G.; Pate, D.; Philips, D.; Seda, T.; Steszyn, A.; Tallerico, T.; Todd, R.; Weiss, D.; White, G.; Zaltsman, A.

    2011-03-28

    The 703 MHz superconducting gun for the BNL Energy Recovery Linac (ERL) prototype has two fundamental power couplers (FPCs), and each of them will deliver up to 500 kW of CW RF power. In order to prepare the couplers for high power RF service and process multipacting, the FPCs should be conditioned prior to installation into the gun cryomodule. A conditioning cart based test stand, which includes a vacuum pumping system, controllable bake-out system, diagnostics, interlocks and data log system has been designed, constructed and commissioned by collaboration of BNL and AES. This paper presents FPC conditioning cart systems and the conditioning process.

  4. Mortalidad materna en el IMSS: un análisis desde la perspectiva de la morbilidad y la letalidad

    OpenAIRE

    Vitelio Velasco-Murillo; Eduardo Navarrete-Hernández

    2006-01-01

    Objetivo: analizar la tendencia de la mortalidad materna hospitalaria en la población derechohabiente del Instituto Mexicano del Seguro Social (IMSS) en el periodo 2000-2003, mediante el estudio de la morbilidad y de la letalidad de sus principales causas, con el fin de identificar las razones de su comportamiento epidemiológico. Material y métodos: se recolectó información sobre 3’357,346 egresos hospitalarios de parto y 832 defunciones maternas ocurridos en las unidades médicas del IMSS en ...

  5. CART peptide induces neuroregeneration in stroke rats.

    Science.gov (United States)

    Luo, Yu; Shen, Hui; Liu, Hua-Shan; Yu, Seong-Jin; Reiner, David J; Harvey, Brandon K; Hoffer, Barry J; Yang, Yihong; Wang, Yun

    2013-02-01

    Utilizing a classic stroke model in rodents, middle cerebral artery occlusion (MCAo), we describe a novel neuroregenerative approach using the repeated intranasal administration of cocaine- and amphetamine-regulated transcript (CART) peptide starting from day 3 poststroke for enhancing the functional recovery of injured brain. Adult rats were separated into two groups with similar infarction sizes, measured by magnetic resonance imaging on day 2 after MCAo, and were treated with CART or vehicle. The CART treatment increased CART level in the brain, improved behavioral recovery, and reduced neurological scores. In the subventricular zone (SVZ), CART enhanced immunolabeling of bromodeoxyuridine, a neural progenitor cell marker Musashi-1, and the proliferating cell nuclear antigen, as well as upregulated brain-derived neurotrophic factor (BDNF) mRNA. AAV-GFP was locally applied to the SVZ to examine migration of SVZ cells. The CART enhanced migration of GFP(+) cells from SVZ toward the ischemic cortex. In SVZ culture, CART increased the size of neurospheres. The CART-mediated cell migration from SVZ explants was reduced by anti-BDNF blocking antibody. Using (1)H-MRS (proton magnetic resonance spectroscopy), increases in N-acetylaspartate levels were found in the lesioned cortex after CART treatment in stroke brain. Cocaine- and amphetamine-regulated transcript increased the expression of GAP43 and fluoro-ruby fluorescence in the lesioned cortex. In conclusion, our data suggest that intranasal CART treatment facilitates neuroregeneration in stroke brain.

  6. TIC para la mejora educativa en aulas hospitalarias

    OpenAIRE

    José Luis Serrano Sánchez; Maria Paz Prendes Espinosa

    2014-01-01

    En este trabajo se presenta una síntesis de los principales resultados del "Proyecto ALTER. Alternativas Telemáticas en Aulas Hospitalarias: una experiencia educativa". Tras analizar las necesidades del contexto de la investigación, observamos que los maestros de las aulas hospitalarias de la Región de Murcia (España) no disponían de criterios de selección y organización de herramientas telemáticas para su uso educativo con el alumnado hospitalizado. En consecuencia, nuestro principal objetiv...

  7. Test and Check Out Cart (T.A.C.O. Cart)

    Science.gov (United States)

    2015-05-14

    Technical Briefing 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Test and Check Out Cart (T.A.C.O. Cart ) 5a. CONTRACT NUMBER...This briefing will discuss the Test and Check-Out (TACO) cart . It is basically a mobile weatherproof laboratory. The primary purpose is to

  8. Des cartes dans la classe…

    Directory of Open Access Journals (Sweden)

    R. Gimeno

    1990-09-01

    Full Text Available La majorité des enseignants qui veulent faire des cartes — et les faire réaliser aux élèves — pour répondre aux exigences des instructions officielles, doivent surmonter leur manque de compétences en cartographie et en didactique ainsi que les difficultés propres aux logiciels de cartographie encore peu performants. Ces compétences et la réflexion qui les accompagne sont pourtant accessibles aux enfants de l’école élémentaire…

  9. Rolling Friction on a Wheeled Laboratory Cart

    Science.gov (United States)

    2012-01-01

    by gravity, and a vehicle (such as a car or bicycle ) accelerating along a level road is driven by a motor or by pedalling. In such cases, static...continuously roll. Consider a cart of mass m that is free rolling up an incline, as sketched in figure 1. The total frictional force f on the cart

  10. The Ballistic Cart on an Incline Revisited.

    Science.gov (United States)

    Serway, Raymond A.; And Others

    1995-01-01

    Presents the theory behind the mechanics demonstration that involves projecting a ball vertically upward from a ballistic cart moving along an inclined plane. The measured overshoot is believed to be due, in part, to the presence of rolling friction and the inertial properties of the cart wheels. (JRH)

  11. Rolling Friction on a Wheeled Laboratory Cart

    Science.gov (United States)

    Mungan, Carl E.

    2012-01-01

    A simple model is developed that predicts the coefficient of rolling friction for an undriven laboratory cart on a track that is approximately independent of the mass loaded onto the cart and of the angle of inclination of the track. The model includes both deformation of the wheels/track and frictional torque at the axles/bearings. The concept of…

  12. [Regulatory assessment of the "Nutrición Hospitalaria" journal].

    Science.gov (United States)

    Iglesias Vázquez, E; Culebras, J M; García de Lorenzo, A

    2000-01-01

    A study is carried out to determine the degree of compliance by the journal entitled "Nutrición Hospitalaria" with the international standards issued by the ISO (International Standards Organization) by means of the application of a survey questionnaire drawn up in accordance with the guidelines published by national and international standards organizations. In total, 161 parameters are considered. Together with the general aspects of the publication, an analysis is made of its specific sections, decisive in the establishment of its level of compliance. After the analysis carried out, it was seen that the general standardization mean was 64% and the real average was 76.82%. At the same time, the necessary recommendations are given to improve these standardization levels and improve the editorial quality of "Nutrición Hospitalaria".

  13. A CART extention using Quadratic Decision Borders

    DEFF Research Database (Denmark)

    Hartelius, Karsten

    1999-01-01

    In this article we put forward an extention to the hierarchical CART classification method which uses quadratic decision borders. The original CART applies univariate splits on individual variables as well as splits on combinations of variables to recursively partition the feature......-space into subsets which are successively more class-homogeneous. Guided by the fact that class-distributions in feature-space are very often hyper-elliptical shaped, we give an extension to the original CART which also uses quadratic shaped decision borders which can be modelled by a mean-vector and a dispersion...

  14. A CART extension using Quadratic Decision Borders

    DEFF Research Database (Denmark)

    Hartelius, Karsten

    1999-01-01

    In this article we put forward an extention to the hierarchical CART classification method which uses quadratic decision borders. The original CART applies univariate splits on individual variables as well as splits on combinations of variables to recursively partition the feature......-space into subsets which are successively more class-homogeneous. Guided by the fact that class-distributions in feature-space are very often hyper-elliptical shaped, we give an extension to the original CART which also uses quadratic shaped decision borders which can be modelled by a mean-vector and a dispersion...

  15. Análise da mortalidade e das internações por doenças cardiovasculares em Niterói, entre 1998 e 2007 Análisis de la mortalidad y de las hospitalizaciones por enfermedades cardiovasculares en Niterói, entre 1998 y 2007 Analysis of mortality and hospitalization for cardiovascular diseases in Niterói, between 1998 and 2007

    Directory of Open Access Journals (Sweden)

    Maria Luiza Garcia Rosa

    2011-06-01

    Full Text Available FUNDAMENTO: A redução da mortalidade por doenças cardiovasculares é observada no Brasil há anos, atribuída à queda nos fatores de risco, melhora na terapêutica e diminuição da mortalidade hospitalar. OBJETIVO: Comparar a mortalidade populacional, o coeficiente de internação e a mortalidade hospitalar em unidades do Sistema Único de Saúde, para doença isquêmica do coração (DIC, doenças cerebrovasculares (DCBV e insuficiência cardíaca (IC, no município de Niterói, entre 1998 e 2007. MÉTODOS: Foram utilizados o número de óbitos e o de internações e mortalidade hospitalar de residentes em Niterói para o capítulo IX do CID10 e causas específicas disponíveis no Datasus, na população de 30 anos e mais. A diferença entre a magnitude dos indicadores foi calculada para homens e mulheres considerando a média do primeiro triênio menos a média do segundo triênio. RESULTADOS: Houve queda dos coeficientes de mortalidade populacional em homens e mulheres, para todas as faixas etárias, nos três grupos de causas e para o capítulo IX. A tendência à queda dos coeficientes diminuiu com a idade. Para DIC houve queda na mortalidade hospitalar. Para DCBV e IC, aumento. Os coeficientes de internação hospitalar por DIC diminuíram, com exceção de algumas faixas. CONCLUSÃO: O presente estudo permitiu esclarecer alguns aspectos da morbimortalidade cardiovascular em Niterói. A redução da mortalidade populacional e hospitalar por DIC indica haver melhor qualidade na abordagem dessa condição. O aumento da mortalidade hospitalar por DCBV e IC aponta para a necessidade de se dar maior atenção à qualidade do cuidado hospitalar para esses grupos de doenças.FUNDAMENTO: La reducción de la mortalidad por enfermedades cardiovasculares se viene observando en Brasil desde hace años, se la asigna a un descenso en los factores de riesgo, a una mejora en el tratamiento y a una mortalidad hospitalaria reducida. OBJETIVO: Para

  16. La mortalidad infantil y la mortalidad materna en el siglo XXI

    OpenAIRE

    Alejandro AGUIRRE

    2009-01-01

    La mortalidad infantil y la mortalidad materna han sido reducidas de manera sustancial en los países desarrollados, por lo cual en esas naciones la mortalidad tiende a concentrarse en las edades avanzadas de las poblaciones. Sin embargo, en países como México no está ocurriendo un avance relevante en la disminución de la mortalidad infantil y materna, pues a pesar de los notables progresos conseguidos en ese sentido durante las décadas recientes, para seguir avanzando se requieren fuertes inv...

  17. Evaluación del estado nutricional al ingreso hospitalario y su asociación con la morbilidad y mortalidad en pacientes mexicanos

    Directory of Open Access Journals (Sweden)

    Juan Emmanuel Pérez-Flores

    Full Text Available Introducción: la desnutrición intrahospitalaria se ha descrito hace más de 70 años como un problema frecuente. En México se reportan cifras de entre el 20% al 50%; sin embargo no se ha estudiado su prevalencia ni su asociación con la morbilidad y mortalidad hospitalaria. Objetivos: evaluar el estado nutricional y su relación con la morbimortalidad hospitalaria en pacientes mexicanos. Métodos: cohorte prospectiva de pacientes que ingresaron en un hospital de referencia para una estancia hospitalaria mayor de 5 días. Se capturó peso, talla, índice de masa corporal (IMC, estado nutricional de acuerdo con la valoración global subjetiva (VGS a su ingreso y egreso hospitalario, así como diagnóstico médico, complicaciones y mortalidad. Los datos fueron analizados mediante la prueba T de Student, prueba Chi-cuadrado y prueba Exacta de Fisher. Resultados: se incluyeron 610 pacientes en total, con un promedio de edad de 50,8 ± 17,32 años, 267 mujeres (43,8% y 343 hombres (56,2%. Del total, 154 fueron catalogados con sospecha de desnutrición o desnutrición (pacientes expuestos, 25,2% y 456 bien nutridos (pacientes no expuestos, 74,8%, con una relación de 1 a 3. La morbilidad total de la cohorte tuvo un RR = 2,70, IC 95 % (2,06-3,55 y la mortalidad con un RR = 2,64, IC 95% (1,74-4,0, siendo ambas estadísticamente signifi cativas (p = 0,001. Conclusiones: el diagnóstico de desnutrición al ingreso hospitalario constituye un factor de riesgo para el desarrollo de complicaciones y mortalidad. Este padecimiento al ingreso en comparación con el paciente que no presenta desnutrición incrementó el riesgo de mortalidad hasta en 2,64 veces.

  18. Getting started with OpenCart module development

    CERN Document Server

    Nepali, Rupak

    2013-01-01

    Written as a step-by-step guide, Getting Started with OpenCart Module Development will teach you all you need to know about OpenCart, from custom extensions to module development.This book is for developers who want to develop OpenCart extensions and for those who want to learn more about the code workflow of OpenCart. Basic knowledge of OpenCart would be an added advantage.

  19. Appetite regulation in Schizothorax prenanti by three CART genes.

    Science.gov (United States)

    Yuan, Dengyue; Wei, Rongbin; Wang, Tao; Wu, Yuanbing; Lin, Fangjun; Chen, Hu; Liu, Ju; Gao, Yundi; Zhou, Chaowei; Chen, Defang; Li, Zhiqiong

    2015-12-01

    In recent years, cocaine- and amphetamine-regulated transcript (CART) has received much attention as mediators of appetite regulation in mammals. However, the involvement of CART in the feeding behavior of teleosts has not been well understood. In this study, three distinct CARTs were cloned from the Schizothorax prenanti (S. prenanti). Real-time quantitative PCR were applied to characterize the tissue distribution and appetite regulatory effects of CARTs in S. prenanti. The S. prenanti CART-1, CART-2 and CART-3 full-length cDNA sequences were 597 bp, 694 bp and 749 bp in length, encoding the peptides of 125, 120 and 104 amino acid residues, respectively. All the S. prenanti CARTs consisted of three exons and two introns. Tissue distribution analysis showed that the high mRNA levels of S. prenanti CART-1 were observed in the telencephalon and eye, followed by the hypothalamus, myelencephalon, and mesencephalon. The S. prenanti CART-2 mRNA was mainly found in the mesencephalon, hypothalamus, telencephalon and myelencephalon. The S. prenanti CART-3 mRNA was widely distributed among the tissues, with the high levels in the hypothalamus and foregut. In the periprandial experiment, all three CARTs mRNA expressions in the hypothalamus were highly elevated after a meal, suggesting that CARTs are postprandial satiety signals. In the fasting experiment, all three CARTs mRNA expressions decreased after fasting and increased after refeeding, suggesting that CARTs might be involved in regulation of appetite in the S. prenanti.

  20. Tasas específicas de mortalidad en el hospital de Algeciras durante el período 1995-1996

    Directory of Open Access Journals (Sweden)

    García Ortega Cesáreo

    1997-01-01

    Full Text Available FUNDAMENTO: La mortalidad intrahospitalaria ha sido propuesta como un indicador de calidad asistencial. Así mismo, es un hecho que debe ser utilizado para la vigilancia epidemiológica y la planificación sanitaria. El objetivo de este trabajo es analizar la mortalidad del Hospital de Algeciras del Servicio Andaluz de Salud. MÉTODOS: Se ha realizado un estudio descriptivo de los enfermos dados de alta entre enero de 1995 y diciembre de 1996, utilizando como fuente de información el informe clínico de alta y/o la historia clínica. Se utilizó la estructura del informe conjunto mínimo básico de datos al alta hospitalaria (CMBD. Los episodios de hospitalización fueron agrupados en los grupos relacionados con el diagnóstico (GRD. Tras un primer análisis de todos los episodios de hospitalización, se analizaron los episodios de alta de los enfermos menores de 80 años, estableciendo el riesgo de fallecer en el hospital en función del motivo de ingreso. RESULTADOS: En el Hospital de Algeciras hubo entre enero de 1995 y diciembre de 1996 un total de 24.194 episodios de hospitalización, tasa de mortalidad del 4.1%. Se observó una mayor tasa de mortalidad en el sexo masculino (5.3% frente al femenino (3.2%, (P<0.01. En los pacientes menores de 80 años se han producido 750 muertes intrahospitalarias y continúa el exceso de mortalidad en el sexo masculino. Las causas más frecuentes de las defunciones en este grupo de edad son: 66 muertes por enfermedad cerebro-vascular (probabilidad de morir este grupo de edad si han ingresado por enfermedad cerebro-vascular IC 95% 0.12-0.19, 58 muertes por Sida (IC95% 0.09-0.15, 51 por neoplasias de bronquios y pulmón (IC95 0.18-0.30, 49 éxitus por infarto agudo de miocardio (IC95% 0.12-0.21, 39 por enfermedad pulmonar obstructiva crónica (IC95% 0.07-0.14.. CONCLUSIONES: Se confirma la numerosa información suministrada por las estadísticas de mortalidad hospitalaria, especialmente si se tienen en

  1. CART peptide in the nucleus accumbens regulates psychostimulants: Correlations between psychostimulant and CART peptide effects.

    Science.gov (United States)

    Job, Martin O; Kuhar, Michael J

    2017-02-16

    In this study, we reexamined the effect of Cocaine-and-Amphetamine-Regulated-Transcript (CART) peptide on psychostimulant (PS)-induced locomotor activity (LMA) in individual rats. The Methods utilized were as previously published. The PS-induced LMA was defined as the distance traveled after PS administration (intraperitoneal), and the CART peptide effect was defined as the change in the PS-induced activity after bilateral intra-NAc administration of CART peptide. The experiments included both male and female Sprague-Dawley rats, and varying the CART peptide dose and the PS dose. While the average effect of CART peptide was to inhibit PS-induced LMA, the effect of CART peptide on individual PS-treated animals was not always inhibitory and sometimes even produced an increase or no change in PS-induced LMA. Upon further analysis, we observed a linear correlation, reported for the first time, between the magnitude of PS-induced LMA and the CART peptide effect. Because CART peptide inhibits PS-induced LMA when it is large, and increases PS-induced LMA when it is small, the peptide can be considered a homeostatic regulator of dopamine (DA)-induced LMA, which supports our earlier homeostatic hypothesis.

  2. [THE TEN MOST CITED ARTICLES OF THE JOURNAL "NUTRICION HOSPITALARIA"].

    Science.gov (United States)

    Franco-López, Ángeles; González-Gallego, Javier; Sanz-Valero, Javier; Tuñón, María Jesús; García-De-Lorenzo, Abelardo; Culebras, Jesús M

    2015-12-01

    After 36 years of continued publication of the journal Nutrición Hospitalaria, a list with the ten most cited articles published in it is elaborated. The top ten most cited articles in the world literature and stratification according to language, English or Spanish, subject, or period of time published are also analyzed. Nutr Hosp is the most important Ibero latin American nutrition journal. Nutr Hosp published 369 items in 2014 gaining the fourth position among all the world's journals devoted to nutrition. Article publication in English, or simultaneously in Spanish and English and Open Access policy probably benefit the number of citations.

  3. Carte tarifaire des CNO: mai 2000

    OpenAIRE

    2014-01-01

    La carte tarifaire de 2002 de Salt Lake est une liste détaillée des produits et services que les comités nationaux olympiques pourront louer durant les Jeux olympiques d’hiver Salt Lake 2002. Le processus de location expliqué dans ce document comprend la commande, la facturation, l’acquisition, la livraison, l’installation, la mise en service, l’entretien sur place ainsi que la collecte et l’enlèvement des produits offerts par l’intermédiaire de la carte tarifaire. Un système simple sera util...

  4. 21 CFR 868.6175 - Cardiopulmonary emergency cart.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cardiopulmonary emergency cart. 868.6175 Section... (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Miscellaneous § 868.6175 Cardiopulmonary emergency cart. (a) Identification. A cardiopulmonary emergency cart is a device intended to store and...

  5. Perfil nutricional de los adultos mayores en una unidad hospitalaria en Costa Rica

    Directory of Open Access Journals (Sweden)

    Isabel Barrientos Calvo

    2014-06-01

    Full Text Available La desnutrición es un estado en el cual existe una deficiencia de energía, proteínas y otros nutrientes, causando efectos adversos en la función corporal. Los estados de déficit nutricionales, se asocian con mayores complicaciones, mayor tiempo de estancia hospitalaria e incremento en la mortalidad. Objetivo: Describir el estado nutricional y las características de los pacientes valorados por el Grupo Clínico de Soporte Nutricional del Hospital Nacional de Geriatría y Gerontología. Metodología: Diseño observacional, transversal y descriptivo. Participaron 204 pacientes mayores de 60 años de edad ingresados al hospital, valorados por el Grupo de Soporte Nutricional entre Junio y Diciembre del 2011. Se utilizaron variables antropométricas y bioquímicas para la valoración del estado nutricional. Se analizaron variables como edad, sexo, comorbilidades, presencia de inmovilización, úlceras por presión (UPP, uso de sondas para alimentación. Se calcularon medidas de frecuencia y medidas de tendencia central. Resultados: el 58,4 % de los pacientes eran de sexo femenino. La edad promedio fue 84,5 años. Con la valoración nutricional se identificó desnutrición proteico calórica (DPC en el 42, 3% de los evaluados, riesgo nutricional en el 31,4 %, sobrepeso en el 2 % y un 5,4 % con obesidad. En los pacientes con DPC, el 57,3 % eran mujeres, el 92,6 % mayores de 75 años; el 76,8 % presentó inmovilización. El 85,4 % presenta un estadio severo de desnutrición. Conclusiones: La mayoría de nuestros pacientes adultos mayores hospitalizados presentaba DPC, con cifras de prevalencia similares a otros estudios.

  6. Chacun sa carte? Le nouveau Google Maps

    Directory of Open Access Journals (Sweden)

    Thierry Joliveau

    2013-08-01

    Full Text Available Google prépare une nouvelle version de Google Maps qu’il est possible de tester en avant-première. L’interface utilisateur est réaménagée pour une plus grande fluidité et une meilleure interactivité entre la carte et les photographies, avec une intégration optimisée des recherches d’itinéraires à la consultation. Mais la principale innovation mise en avant par la firme est plus radicale. Dans cette nouvelle version, la carte va s’adapter à l’utilisateur: «plus vous utilisez la carte plus elle devient utile», annonce Google. Le principe est simple. En fonction de vos recherches, des endroits que vous visitez, des lieux conseillés par vos amis sur les réseaux et des remarques que vous ajoutez, Google Maps apprendra à mieux cerner vos intérêts et vous proposera un contenu plus adapté. La carte est personnalisée et intègre les habitudes et les besoins de l’utilisateur.

  7. Comment les jeunes gens utilisent les cartes

    Directory of Open Access Journals (Sweden)

    H. Sandford

    1990-09-01

    Full Text Available Des recherches sur l’utilisation des cartes dans les collèges et les lycées révèlent une hiérarchie de procédés qui met au jour des lacunes dans la formation au niveau secondaire.

  8. Factores asociados a mortalidad intrahospitalaria de una población en hemodiálisis en el Perú

    Directory of Open Access Journals (Sweden)

    Percy Herrera-Añazco

    2015-09-01

    Full Text Available Objetivos. Determinar los factores asociados a la mortalidad durante la primera hospitalización de una población incidente en hemodiálisis. Materiales y métodos. Estudio observacional y retrospectivo de pacientes que ingresaron al Hospital Nacional Dos de Mayo entre enero de 2012 y diciembre de 2013. Para el análisis de la supervivencia utilizamos el método de Kaplan-Meier. Se realizó un análisis de regresión logístico multivariado para evaluar los factores asociados a mortalidad intrahospitalaria. Resultados. Se estudiaron 216 pacientes con edad promedio de 56,9 ± 15,5 años. El 24% de los paciente (n=51 fallecieron durante la estancia hospitalaria. La tasa de mortalidad fue de 9,3 muertes/100 personas-semanas (IC 95%: 7,0 a 12,3. Se evidenció una tendencia a menor riesgo de fallecer en pacientes que tenían entre uno y seis meses con diagnóstico de enfermedad renal crónica (OR 0,84; IC 95%: 0,32 a 2,26, y en aquellos con más de seis meses comparado con aquellos que lo tenían hace menos de un mes (OR 0,55; IC 95%: 0,19 a 1,57. La atención previa por un nefrólogo no estuvo asociada a diferencias en la mortalidad menor (OR 1,14; IC 95%: 0,39 a 3,31. Conclusiones. Existe una deficiente atención previa entre los pacientes en hemodiálisis que forman parte de una inadecuada estructura de atención de salud y que está asociado a una alta mortalidad intrahospitalaria

  9. Factores asociados a mortalidad intrahospitalaria de una población en hemodiálisis en el Perú

    Directory of Open Access Journals (Sweden)

    Percy Herrera-Añazco

    2015-07-01

    Full Text Available Objetivos. Determinar los factores asociados a la mortalidad durante la primera hospitalización de una población incidente en hemodiálisis. Materiales y métodos. Estudio observacional y retrospectivo de pacientes que ingresaron al Hospital Nacional Dos de Mayo entre enero de 2012 y diciembre de 2013. Para el análisis de la supervivencia utilizamos el método de Kaplan-Meier. Se realizó un análisis de regresión logístico multivariado para evaluar los factores asociados a mortalidad intrahospitalaria. Resultados. Se estudiaron 216 pacientes con edad promedio de 56,9 ± 15,5 años. El 24% de los paciente (n=51 fallecieron durante la estancia hospitalaria. La tasa de mortalidad fue de 9,3 muertes/100 personas-semanas (IC 95%: 7,0 a 12,3. Se evidenció una tendencia a menor riesgo de fallecer en pacientes que tenían entre uno y seis meses con diagnóstico de enfermedad renal crónica (OR 0,84; IC 95%: 0,32 a 2,26, y en aquellos con más de seis meses comparado con aquellos que lo tenían hace menos de un mes (OR 0,55; IC 95%: 0,19 a 1,57. La atención previa por un nefrólogo no estuvo asociada a diferencias en la mortalidad menor (OR 1,14; IC 95%: 0,39 a 3,31. Conclusiones. Existe una deficiente atención previa entre los pacientes en hemodiálisis que forman parte de una inadecuada estructura de atención de salud y que está asociado a una alta mortalidad intrahospitalaria

  10. [Evaluation of the journal Nutrición Hospitalaria. II. Productivity and collaboration].

    Science.gov (United States)

    Iglesias Vázquez, E; Culebras, J M; García de Lorenzo, A

    2001-01-01

    An analysis is effected of the production by authors publishing their papers in Nutrición Hospitalaria (Hospital Nutrition), as well as by the institutions at which these authors work. The productivity figures indicate a large group of sporadic authors, whereas the "regular contributors" exceed figure 1 in the indices established. In terms of collaboration, Nutrición Hospitalaria articles present between 3 and 5 signatories per paper, lower than in other journals in the same scientific field.

  11. The burden of hospital malnutrition in Spain: methods and development of the PREDyCES® study El coste de la desnutrición hospitalaria en España: método y desarrollo del estudio PREDyCES®

    Directory of Open Access Journals (Sweden)

    M. Planas Vila

    2010-12-01

    Full Text Available It is well known that hospital malnutrition is a highly prevalent condition associated to increase morbidity and mortality as well as related healthcare costs. Although previous studies have already measured the prevalence and/or costs of hospital nutrition in our country, their local focus (at regional or even hospital level make that the true prevalence and economic impact of hospital malnutrition for the National Health System remain unknown in Spain. The PREDyCES® (Prevalence of hospital malnutrition and associated costs in Spain study was aimed to assess the prevalence of hospital malnutrition in Spain and to estimate related costs. Some aspects made this study unique: a It was the first study in a representative sample of hospitals of Spain; b different measures to assess hospital malnutrition (NRS2002, MNA as well as anthropometric and biochemical markers where used both at admission and discharge and, c the economic consequences of malnutrition where estimated using the perspective of the Spanish National Health System.Es bien sabido que la desnutrición hospitalaria es un proceso altamente prevalente asociado al aumento de la morbilidad y mortalidad, así como a elevados costes sanitarios. Aunque estudios previos han medido la prevalencia y/o los costes de la nutrición hospitalaria en nuestro país, su enfoque local (regional o incluso a nivel hospitalario hacen que la verdadera prevalencia e impacto económico de la desnutrición hospitalaria para el Sistema Nacional de Salud sean aún desconocidos en España. El objetivo del estudio PREDyCES® (Prevalencia de la Desnutrición hospitalaria y los Costes asociados en ESpaña fue evaluar la prevalencia de la desnutrición hospitalaria en España y estimar sus costes asociados. Algunos aspectos de este estudio lo hicieron singular: a Fue el primer estudio de este tipo con una muestra representativa de los hospitales de España, b se utilizaron diferente medidas para evaluar la desnutrici

  12. CART in the regulation of appetite and energy homeostasis.

    Science.gov (United States)

    Lau, Jackie; Herzog, Herbert

    2014-01-01

    The cocaine- and amphetamine-regulated transcript (CART) has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s). However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions (Rogge et al., 2008; Subhedar et al., 2014). In this review, we focus on knowledge gained on CART's role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans.

  13. CART in the regulation of appetite and energy homeostasis

    Science.gov (United States)

    Lau, Jackie; Herzog, Herbert

    2014-01-01

    The cocaine- and amphetamine-regulated transcript (CART) has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s). However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions (Rogge et al., 2008; Subhedar et al., 2014). In this review, we focus on knowledge gained on CART's role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans. PMID:25352770

  14. MORTALIDAD POR ABORTO EN CHILE: ANALISIS EPIDEMIOLOGICO 1985-2000

    OpenAIRE

    Szot M,Jorge; Moreno W,Cristina

    2003-01-01

    El aborto, por su contribución a la mortalidad materna, ha sido tradicionalmente un problema de salud pública en América Latina y en Chile. En la actualidad, si bien es cierto la mortalidad por esta causa ha disminuido, la cantidad de abortos realizados permanece alta. Por este motivo, se ha querido efectuar una caracterización desde la perspectiva epidemiológica de la mortalidad por aborto ocurrido en Chile entre 1985 y 2000. Los resultados confirman la baja en la mortalidad durante el perío...

  15. Preparación Hospitalaria en incidentes NBQ

    Directory of Open Access Journals (Sweden)

    A. Cique Moya

    2015-03-01

    Full Text Available Los incidentes de Goainia, Matsumoto, Tokio, así como la crisis del carbunco muestran que los hospitales intervienen de forma directa en la respuesta a incidentes NBQ, debiendo estar integrados en el sistema de respuesta a desastres junto con los servicios de asistencia prehospitalaria para poder dar una respuesta efectiva a este tipo de accidentes. Los retos organizativos y de gestión a los que tiene que hacer frente la estructura hospitalaria ante un incidente no sólo afectan a los servicios de urgencias, sino que trascienden a ésta, debiendo estar contemplados en el Plan de Emergencia del Centro Hospitalario. La respuesta pasa por el establecimiento de un plan de mejora continua en la instalación mediante la valoración del índice de seguridad de la instalación y la preparación, individual y colectiva, del centro sanitario para activar el plan de emergencias de forma inmediata una vez establecida la alarma, para así evitar los problemas de transferencia de contaminación a las instalaciones y al personal minimizando las consecuencias de un incidente NBQ.

  16. Using CART to segment road images

    Science.gov (United States)

    Davies, Bob; Lienhart, Rainer

    2006-01-01

    The 2005 DARPA Grand Challenge is a 132 mile race through the desert with autonomous robotic vehicles. Lasers mounted on the car roof provide a map of the road up to 20 meters ahead of the car but the car needs to see further in order to go fast enough to win the race. Computer vision can extend that map of the road ahead but desert road is notoriously similar to the surrounding desert. The CART algorithm (Classification and Regression Trees) provided a machine learning boost to find road while at the same time measuring when that road could not be distinguished from surrounding desert.

  17. The Retarding Force on a Fan-Cart Reversing Direction

    Science.gov (United States)

    Aurora, Tarlok S.; Brunner, Bernard J.

    2011-01-01

    In introductory physics, students learn that an object tossed upward has a constant downward acceleration while going up, at the highest point and while falling down. To demonstrate this concept, a self-propelled fan cart system is used on a frictionless track. A quick push is given to the fan cart and it is allowed to move away on a track under…

  18. CART in the brain of vertebrates: circuits, functions and evolution.

    Science.gov (United States)

    Subhedar, Nishikant K; Nakhate, Kartik T; Upadhya, Manoj A; Kokare, Dadasaheb M

    2014-04-01

    Cocaine- and amphetamine-regulated transcript peptide (CART) with its wide distribution in the brain of mammals has been the focus of considerable research in recent years. Last two decades have witnessed a steady rise in the information on the genes that encode this neuropeptide and regulation of its transcription and translation. CART is highly enriched in the hypothalamic nuclei and its relevance to energy homeostasis and neuroendocrine control has been understood in great details. However, the occurrence of this peptide in a range of diverse circuitries for sensory, motor, vegetative, limbic and higher cortical areas has been confounding. Evidence that CART peptide may have role in addiction, pain, reward, learning and memory, cognition, sleep, reproduction and development, modulation of behavior and regulation of autonomic nervous system are accumulating, but an integration has been missing. A steady stream of papers has been pointing at the therapeutic potentials of CART. The current review is an attempt at piecing together the fragments of available information, and seeks meaning out of the CART elements in their anatomical niche. We try to put together the CART containing neuronal circuitries that have been conclusively demonstrated as well as those which have been proposed, but need confirmation. With a view to finding out the evolutionary antecedents, we visit the CART systems in sub-mammalian vertebrates and seek the answer why the system is shaped the way it is. We enquire into the conservation of the CART system and appreciate its functional diversity across the phyla.

  19. Um corpo de cartógrafo

    Directory of Open Access Journals (Sweden)

    Flavia Liberman

    2015-03-01

    Full Text Available A cartografia tem sido discutida no Brasil como um método em pesquisa que pressupõe uma reversão metodológica na qual o caminhar na pesquisa antecede a definição de metas a serem alcançadas. Este texto busca contribuir para as discussões sobre a formação do cartógrafo, considerando que, para se realizar uma pesquisa na perspectiva cartográfica, é preciso um corpo que mobilize algumas qualidades, como: atenção, presença, disponibilidade, sensibilidade, entre outras. Ao aproximar nossa experiência teórico-prática do pensamento de autores ligados à filosofia da diferença e das ideias de Keleman e Favre sobre temáticas que envolvem o corpo, buscou-se sistematizar algumas guias para a construção de um corpo de cartógrafo, que pudessem servir de orientação na pesquisa, na prática profissional e nos processos de ensino-aprendizagem. Ao longo do texto, procuramos pensar a construção de dispositivos que promovam encontros plasmados por afetos e acontecimentos.

  20. CART in the Regulation of Appetite and Energy Homeostasis

    Directory of Open Access Journals (Sweden)

    Jackie eLau

    2014-10-01

    Full Text Available The cocaine- and amphetamine-regulated transcript (CART has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s. However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions1,2. In this review, we focus on knowledge gained on CART’s role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans.

  1. Establishing guidelines for CAR-T cells: challenges and considerations.

    Science.gov (United States)

    Wang, Wei; Qin, Di-Yuan; Zhang, Bing-Lan; Wei, Wei; Wang, Yong-Sheng; Wei, Yu-Quan

    2016-04-01

    T cells, genetically modified by chimeric antigen receptors (CAR-T), are endowed with specificity to a desired antigen and are cytotoxic to cells expressing the targeted antigen. CAR-T-based cancer immunotherapy is a promising therapy for curing hematological malignancy, such as acute lymphoid leukemia, and is promising for extending their efficacy to defeat solid tumors. To date, dozens of different CAR-T cells have been evaluated in clinical trials to treat tumors; this necessitates the establishment of guidelines for the production and application of CAR-T cells. However, it is challenging to standardize CAR-T cancer therapy because it involves a combination of gene therapy and cell therapy. In this review, we compare the existing guidelines for CAR-T cells and discuss the challenges and considerations for establishing guidance for CAR-T-based cancer immunotherapy.

  2. Sistemas de Información de costos para la gestión hospitalaria

    OpenAIRE

    Vilma Vargas González; Carmen Hernández

    2009-01-01

    El presente trabajo pretende exponer aspectos fundamentales para el desarrollo de sistemas de información de costos para la gestión hospitalaria. Sistemas de información de costos, útiles en la toma de decisiones para la gestión hospitalaria, y cónsonos con los objetivos sociales que persiguen los hospitales, implica que el conocimiento de información de costos no tiene como objetivo la búsqueda de rentabilidad económica, sino optimización del uso de los recursos desde el punto de vista socia...

  3. Evaluation of the New York City Green Carts program

    Directory of Open Access Journals (Sweden)

    Shannon M Farley

    2015-12-01

    Full Text Available Access to fresh fruits and vegetables is a concern, particularly among low-income populations. Mobile vending is one strategy to expand produce availability and access to increase consumption. In 2008, New York City launched a mobile vending initiative, Green Carts. We report on the evaluation. Three waves of cross-sectional observational surveys of produce availability, variety, and quality were conducted during the summers of 2008, 2009, and 2011 in a stratified random sample of stores and carts comparing establishments in Green Cart neighborhoods (n = 13 with comparison neighborhoods (n = 3. Bivariate analyses for availability, variety, and quality comparing Green Cart and comparison neighborhoods were presented across years, and logistic and negative binomial regressions were used to test whether fruit and vegetable availability, variety, and quality increased in Green Cart compared with comparison neighborhoods, adjusting for clustering and neighborhood demographics. Establishments selling fruits and vegetables in Green Cart neighborhoods increased between 2008 and 2011 (50% to 69%, p <0.0001; there was no comparable increase in comparison neighborhoods. Establishments selling more than 10 fruits and vegetables types increased from 31% to 38% (p = 0.0414 in Green Cart neighborhoods; there was no change in comparison neighborhoods. Produce quality was high among comparison establishments, with 95% and 94% meeting the quality threshold in 2008 and 2011, while declining in Green Cart neighborhood establishments from 96% to 88% (p < 0.0001. Sustained produce availability was found in Green Cart neighborhoods between 2008–2011. Green Carts are one strategy contributing to improving produce access among New Yorkers.

  4. Estudio aleatorio de dos emulsiones grasas diferentes en la nutrición parenteral total del enfermo quirúrgico desnutrido: efecto sobre la morbilidad infecciosa y la mortalidad Randomized study of two different fat emulsions in total parenteral nutrition of malnourished surgical patients: effect on infectious morbidity and mortality

    OpenAIRE

    T. Grau; J. Carlos Ruiz de Adana; S. Zubillaga; S. Fuerte; C. Girón

    2003-01-01

    Objetivo: Las infusiones lipídicas de una mezcla física de triglicéridos de cadena media/triglicéridos de cadena larga (MCT/LCT), utilizadas en la nutrición parenteral total (NPT) peroperatoria, tienen menos efecto inmunosupresor en estudios de laboratorio que las emulsiones que contienen únicamente triglicéridos de cadena larga (LCT). El objetivo de este estudio fue comparar la incidencia de infecciones nosocomiales y la mortalidad hospitalaria de los pacientes quirúrgicos severamente desnut...

  5. University of Pennsylvania aspiration cart (Penn-A-Cart): an innovative journey in fine needle aspiration service.

    Science.gov (United States)

    Gupta, Prabodh K

    2010-01-01

    On-site evaluation of fine needle aspiration specimens is now considered the standard of care. The procedure is performed at the bedside and at various other locations within the hospital using a mobile cart fitted with essentials, including a microscope, stains and supplies. Earlier, an open specimen cart was used with various supplies and a binocular microscope. The mobile cart during the past 25 years has been variously modified. A second-generation cart containing 2 folding pods, a double-headed microscope, supplies and stains had been used for the past 20 years; it did not meet the current regulatory standards and needs, and little attention was paid to meet the Joint Commission on the Accreditation of Healthcare Organizations, Health Insurance Portability and Accountability Act and infection control standards. Also, the repeated lifting of the microscope resulted in much wear and tear. We have designed Penn-A-Cart, which has a pneumatic lift for the microscope, a high-definition camera with a TV screen and access to the Internet. It has a sharps container and storage space for supplies, stains and slides. This cart meets the various regulatory agency standards. It is user friendly and valuable for multiviewing. The cart is valuable for remote access, telecytopathology and improved patient care.

  6. La mortalidad perinatal según 2 fuentes de información Perinatal mortality according to 2 information sources

    Directory of Open Access Journals (Sweden)

    Adriana Freitas Ramírez

    2008-08-01

    Full Text Available Objetivo: Evaluar la diferencia en muertes perinatales (MP ocurridas en Cataluña y su evolución según 2 fuentes de información sanitaria. Métodos: Los datos proceden de la estadística de mortalidad (Departament de Salut e Institut d'Estadística de Catalunya y del Conjunto Mínimo Básico de Datos de Altas Hospitalarias (CMBDAH del Servei Català de la Salut del período 2000-2003. Se describen las frecuencias totales de MP según si cumplen o no criterio legal de declaración. Resultados: La estadística de mortalidad registró un 27,2% menos de MP, un 44,77% menos de muertes fetales y un 13,5% más de muertes neonatales precoces que el CMBDAH. Estos porcentajes son menores considerando sólo los casos con criterios legales de declaración. Conclusión: Las diferencias de casos entre ambas fuentes están relacionadas con características del recién nacido: bajo peso al nacer, prematuridad y lugar en que se produjo. Los datos hospitalarios podrían mejorar la estadística de mortalidad perinatal.Objective: To evaluate differences in the number of cases of perinatal mortality in Catalonia (Spain recorded in 2 health information systems, as well as trends in this phenomenon. Methods: Data were obtained from the mortality statistics (Health Department and the Catalan Institute of Statistics and the minimum data set (MDS for hospital discharges of the Catalan Health Service from 2000-2003. The frequencies are given for the cases reported and for cases following the legal criteria for reporting. Results: The mortality statistics registered 27.2% fewer perinatal deaths, 44.77% fewer fetal deaths and 13.5% more early neonatal deaths than the MDS. These percentages were lower when only the cases following the legal criteria for reporting were considered. Conclusion: The differences between the two sources were related to low birth weight, prematurity, and the place of occurrence. Use of hospital data might improve the quality of perinatal

  7. Classification and Regression Trees(CART) Theory and Applications

    OpenAIRE

    Timofeev, Roman

    2004-01-01

    This master thesis is devoted to Classification and Regression Trees (CART). CART is classification method which uses historical data to construct decision trees. Depending on available information about the dataset, classification tree or regression tree can be constructed. Constructed tree can be then used for classification of new observations. The first part of the thesis describes fundamental principles of tree construction, different splitting algorithms and pruning procedures. Seco...

  8. Potential Antidepressant Role of Neurotransmitter CART: Implications for Mental Disorders

    Directory of Open Access Journals (Sweden)

    Peizhong Mao

    2011-01-01

    Full Text Available Depression is one of the most prevalent and debilitating public health concerns. Although no single cause of depression has been identified, it appears that interaction among genetic, epigenetic, biochemical, environmental, and psychosocial factors may explain its etiology. Further, only a fraction of depressed patients show full remission while using current antidepressants. Therefore, identifying common pathways of the disorder and using that knowledge to develop more effective pharmacological treatments are two primary targets of research in this field. Brain-enriched neurotransmitter CART (cocaine- and amphetamine-regulated transcript has multiple functions related to emotions. It is a potential neurotrophic factor and is involved in the regulation of hypothalamic-pituitary-adrenal axis and stress response as well as in energy homeostasis. CART is also highly expressed in limbic system, which is considered to have an important role in regulating mood. Notably, adolescents carrying a missense mutation in the CART gene exhibit increased depression and anxiety. Hence, CART peptide may be a novel promising antidepressant agent. In this paper, we summarize recent progress in depression and CART. In particular, we emphasize a new antidepressant function for CART.

  9. El factor de impacto de Nutrición Hospitalaria es 1,096 The impact factor of Nutrición Hospitalaria is 1.096

    OpenAIRE

    J. M. Culebras; A. García de Lorenzo

    2009-01-01

    El director y el redactor jefe de Nutrición Hospitalaria (Nutr Hosp) analizan la revista desde su fundación en 1979 hasta el momento actual, con ocasion de la primera aparición de su factor de impacto publicada por Journal Citation Reports (JCR). Se describen las acciones realizadas durante este periodo de treinta años, que incluyen su incorporación a múltiples bases de datos de la Web, la política de Open Access llevada a cabo, su progresiva internacionalización, y el análisis bibliometrico ...

  10. Sistemas de Información de costos para la gestión hospitalaria

    Directory of Open Access Journals (Sweden)

    Vilma Vargas González

    2009-01-01

    Full Text Available El presente trabajo pretende exponer aspectos fundamentales para el desarrollo de sistemas de información de costos para la gestión hospitalaria. Sistemas de información de costos, útiles en la toma de decisiones para la gestión hospitalaria, y cónsonos con los objetivos sociales que persiguen los hospitales, implica que el conocimiento de información de costos no tiene como objetivo la búsqueda de rentabilidad económica, sino optimización del uso de los recursos desde el punto de vista social. En la elaboración del estudio, se realizó un análisis teórico-bibliográfico, articulación de la teoría con la evidencia empírica y revisión del marco legal. Se concluye sobre la necesidad de fortalecer el cálculo y desarrollo de indicadores y sistemas de información de costos con personal capacitado para su implementación, asegurando la confiabilidad, pertinencia y oportunidad de los resultados generados por dichos sistemas, y su uso efectivo para la gestión hospitalaria.

  11. CART (cocaine- and amphetamine-regulated transcript) peptide specific binding sites in PC12 cells have characteristics of CART peptide receptors.

    Science.gov (United States)

    Nagelová, Veronika; Pirník, Zdeno; Železná, Blanka; Maletínská, Lenka

    2014-02-14

    CART (cocaine- and amphetamine-regulated transcript) peptide is a neuropeptide with a powerful central anorexigenic effect. Specific CART peptide binding sites, most likely CART peptide receptors, have been found in PC12 cells. This study further characterizes the CART peptide binding sites in PC12 cells. After differentiation to a neuronal phenotype with nerve growth factor, the number of CART peptide binding sites in PC12 cells tripled. Following dexamethasone treatment, which transforms PC12 cells into chromaffin-like cells, the number of CART peptide binding sites substantially decreased. CART peptide did not affect the differentiation or acetylcholinesterase activity of PC12 cells, indicating that CART peptide does not participate in differentiation or neuronal activity. CART peptide increased the phosphorylation of SAPK/JNK (stress-activated protein kinase/c-Jun-amino-terminal kinase) and subsequent c-Jun protein expression. These effects were reversed by SP600125, a specific JNK-kinase inhibitor. CART peptide did not significantly affect ERK (extracellular signal-regulated kinase), CREB (cAMP responsive element binding protein), or p38 phosphorylation and c-Fos protein expression. Central administration of CART peptide into mice also resulted in increased c-Jun positive cells in dorsomedial hypothalamic nucleus and nucleus of the solitary tract, areas involved in food intake regulation. Activation of c-Jun by CART peptide might indicate a possible role of CART peptide in managing stress conditions rather than a role in cell proliferation or differentiation as well as the more complex and/or specific regulation ways by transcription factors in some nuclei involved in food intake regulation. The characteristics of stress that CART peptide potentially mediates should be further studied.

  12. Estudio longitudinal de mortalidad de adultos costarricenses 1984-2007

    Directory of Open Access Journals (Sweden)

    Rosero-Bixby, Luis

    2010-01-01

    Full Text Available Se describen los procedimientos y se presentan algunos resultados del “estudio longitudinal de mortalidad de adultos costarricenses” (ELMAC, consistente en una muestra de cerca de 20.000 costarricenses de 30 o más años de edad del censo de población de 1984 seguidos hasta fines de 2007. El Instituto Nacional de Estadística y Censos (INEC digitalizó los nombres de la boleta censal de los individuos en la muestra. Procesos informáticos depuraron los nombres y los enlazaron al número único de identificación –el número de cédula– del Registro Civil. El empate se efectuó en el 87% de la muestra. Los individuos identificados se siguieron en las bases de datos del Registro Civil para establecer su sobrevivencia. Se identificaron más de 5.000 defunciones entre el censo de 1984 y diciembre de 2007. Procesos informáticos adicionales enlazaron 92% de estas defunciones con las de las estadísticas vitales del INEC que contienen el dato de la causa de defunción. El patrón de mortalidad de la muestra, que comprende 373.000 personas-años de observación, reproduce bien las tasas de las tablas de mortalidad del país. Las gradientes socioeconómicas de la mortalidad en esta muestra no son sensibles a posibles errores en los empates o en las imputaciones efectuadas. La muestra confirma la excepcionalmente baja mortalidad de los adultos costarricenses, especialmente de los varones. Esta muestra abre la puerta para que se efectúen variedad de análisis de los determinantes socioeconómicos de la mortalidad de adultos en Costa Rica, algo rara vez intentado en un país en desarrollo.

  13. Association between nutritional risk based on the NRS-2002 test and hospital morbidity and mortality Evaluación de la asociación entre el grado de riesgo nutricional según el test NRS-2002 y la morbimortalidad hospitalaria

    Directory of Open Access Journals (Sweden)

    G. Mercadal-Orfila

    2012-08-01

    todos: Estudio transversal de 1075 pacientes que ingresaron en el Hospital Mateu Orfila (Menorca de los que se disponía una analítica de ingreso y valoración del riesgo nutricional (RN mediante el test NRS-2002. Se recogieron datos demográficos (edad, sexo y clínicos (peso actual, peso habitual, Índice Masa Corporal, pérdida peso, ingesta oral, presencia de fracaso intestinal, fístula, fracaso renal, infección respiratoria, infección urinaria, hiperglucemia, estancia en la UCI, estancia hospitalaria, días de tratamiento de nutrición parenteral y enfermedad motivo de ingreso durante su hospitalización así como la mortalidad hospitalaria y a los 6 meses posteriores al alta. Resultados: La edad media de los pacientes fue de 67,9 años y el 58,3% eran hombres. El 62%de los pacientes presentaron criterios de DN según el test NRS-2002. Se halló asociación estadísticamente significativa entre DN según el test NRS-2002 y fracaso intestinal, fístula, fracaso renal, infección respiratoria, hiperglucemia, mortalidad hospitalaria, mortalidad 6 meses y estancia hospitalaria. Conclusiones: La DN afecta a más de la mitad de los pacientes que ingresan en un hospital de media-larga estancia y se asocia con mayor morbi-mortalidad. Los resultados nos permiten establecer un plan de actuación y seguimiento nutricional de prevención y tratamiento.

  14. La mortalidad en Cádiz (1900-1920)

    OpenAIRE

    Rodríguez Aguado, Orestes Octavio

    2016-01-01

    El comportamiento de la mortalidad en Cádiz entre 1900 y 1920 es el objeto central de nuestra tesis doctoral. Para conseguirlo pretendemos contrastar las siguientes hipótesis de trabajo: * El patrón demográfico del mortalidad de Cádiz en el periodo estudiado es equivalente al del resto de España. * Las causas de muerte encontradas ponen de manifiesto tanto causas endógenas de origen biológicos como causas exógenas (sociales, económicas, educativas y sanitarias). * El predominio de ...

  15. Simulation and Test of a Fuel Cell Hybrid Golf Cart

    Directory of Open Access Journals (Sweden)

    Jingming Liang

    2014-01-01

    Full Text Available This paper establishes the simulation model of fuel cell hybrid golf cart (FCHGC, which applies the non-GUI mode of the Advanced Vehicle Simulator (ADVISOR and the genetic algorithm (GA to optimize it. Simulation of the objective function is composed of fuel consumption and vehicle dynamic performance; the variables are the fuel cell stack power sizes and the battery numbers. By means of simulation, the optimal parameters of vehicle power unit, fuel cell stack, and battery pack are worked out. On this basis, GUI mode of ADVISOR is used to select the rated power of vehicle motor. In line with simulation parameters, an electrical golf cart is refitted by adding a 2 kW hydrogen air proton exchange membrane fuel cell (PEMFC stack system and test the FCHGC. The result shows that the simulation data is effective but it needs improving compared with that of the real cart test.

  16. Object Transportation by Two Mobile Robots with Hand Carts.

    Science.gov (United States)

    Sakuyama, Takuya; Figueroa Heredia, Jorge David; Ogata, Taiki; Hara, Tatsunori; Ota, Jun

    2014-01-01

    This paper proposes a methodology by which two small mobile robots can grasp, lift, and transport large objects using hand carts. The specific problems involve generating robot actions and determining the hand cart positions to achieve the stable loading of objects onto the carts. These problems are solved using nonlinear optimization, and we propose an algorithm for generating robot actions. The proposed method was verified through simulations and experiments using actual devices in a real environment. The proposed method could reduce the number of robots required to transport large objects with 50-60%. In addition, we demonstrated the efficacy of this task in real environments where errors occur in robot sensing and movement.

  17. Les voix/voies de la carte

    Directory of Open Access Journals (Sweden)

    Louise Bénat-Tachot

    2012-01-01

    Full Text Available La confection du padrón real par les experts de la Casa de la Contratación de Séville dans la première moitié du XVIe siècle, a été un enjeu majeur non seulement pour établir la nouvelle configuration globale du monde mais aussi pour légitimer les entreprises d’expansion des nations ibériques en affirmant la maîtrise de la navigation. Dans quelle mesure la rédaction des premières chroniques des Indes est-elle liée à cette activité cartographique d’état qui lui est contemporaine ? Les liens épistémologiques, rhétoriques et politiques qui lient ces deux productions seront étudiés à partir de la carte universelle de Diego de Ribeiro et de deux chroniques : celle de Gonzalo Fernández de Oviedo et celle de Francisco López de Gómara.La confección del padrón real por los expertos de la Casa de la Contratación de Sevilla durante la primera mitad del siglo XVI, fue de mayor trascendencia no sólo por cartografiar la nueva configuración del mundo sino también porque legitimaba la empresa de expansión de las naciones ibéricas así como para afirmaba su dominio de la navegación. ¿ En qué medida se vincula la redacción de las primeras crónicas de Indias con esta actividad de estado cartográfica contemporánea ? Los vínculos epistemológicos, retóricos y políticos que unen estas dos producciones serán analizados a partir de la carta universal de Diego de Ribeiro y de las dos crónicas primitivas de Indias : la de Gonzalo Fernández de Oviedo y la de Francisco López de Gómara.

  18. Reduced CSF CART in dementia with Lewy bodies

    DEFF Research Database (Denmark)

    Schultz, Kristofer; Wiehager, Sara; Nilsson, Karin

    2009-01-01

    Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study......, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB...

  19. Desigualdade de indicadores de mortalidade no Sudeste do Brasil

    Directory of Open Access Journals (Sweden)

    Ricardo Cordeiro

    1999-12-01

    Full Text Available INTRODUÇÃO: Há indícios de que a deterioração das condições de trabalho ocorrida em anos recentes influencie a mortalidade. O objetivo do estudo é estimar indicadores de mortalidade para a população de Botucatu, classificada de acordo com as ocupações exercidas. MÉTODO: Foram calculados os indicadores coeficiente de mortalidade padronizado (CMP, razão de risco padronizada e anos potenciais de vida perdidos (APVP para a população de Botucatu, em 1997, segundo ocupações e causas básicas do óbito. RESULTADOS: Os indicadores CMP e APVP variaram entre 0,6 e 39,9 óbitos/1000 trabalhadores e entre 33 e 334 anos/1000 trabalhadores, respectivamente, de acordo com a ocupação principal exercida. Observou-se que a ordenação quantitativa das causas de óbito depende da ocupação e do indicador utilizado. CONCLUSÕES: Os indicadores de mortalidade verificados apresentam uma grande heterogeneidade quando analisados de acordo com ocupação e causas básicas de óbito, refletindo a enorme desigualdade social existente na população estudada.

  20. Art on a Cart: A National Mixed Methods Investigation of Elementary Art Teacher Experiences and Perceptions

    Science.gov (United States)

    Lung, Heidi K.

    2013-01-01

    This study investigated the practice of elementary art teachers who utilize carts for the delivery of art lessons; to understand how the art on a cart practice influences art educators' approaches to curriculum development and instruction; and to identify challenges, benefits, and best practices. The practice of art on a cart is defined as the…

  1. Negligible Details? On a Study of Terracotta Miniature Carts from a Harappan site in Gujarat

    Directory of Open Access Journals (Sweden)

    Elke Rogersdotter

    2006-12-01

    Full Text Available This paper deals with results obtained from an analysed assemblage of Harappan toy- or model carts. It aims to put forward the particular value of studying a limited number of objects while concentrating on details. It further prefers to approach the items not primarily as representations of full-sized carts, but as that what they are; that is, miniature carts.

  2. Validez del protocolo de adecuación de urgencias hospitalarias

    Directory of Open Access Journals (Sweden)

    Selva Teresa Sempere

    1999-01-01

    Full Text Available FUNDAMENTO: Diversos trabajos sitúan la proporción de visitas inadecuadas a los servicios de urgencia hospitalarios entre el 20% y el 80% del total. Este amplio intervalo se debe, en buena parte, a la inexistencia de un consenso en torno a la definición de urgencia y el nivel asistencial idóneo para la atención de cada situación posible que conduce al uso de juicios subjetivos para evaluar la inadecuación. El objetivo de este trabajo es desarrollar y validar un instrumento objetivo de identificación de urgencias hospitalarias inadecuadas. MÉTODO: A partir de un marco conceptual que incluía como dimensiones la gravedad clínica del paciente, la intensidad de los servicios prestados y algunas situaciones que justificarían la adecuación de las visitas espontaneas, se construyó el Protocolo de Adecuación de Urgencias Hospitalarias, un instrumento con criterios explícitos para evaluar la adecuación de las visitas a los servicios de urgencia hospitalarios y se evaluó, en una muestra aleatoria de 100 historias clínicas de urgencias, su fiabilidad intra y entre observadores y su validez de criterio y predictiva frente al juicio de expertos. RESULTADOS: El Protocolo de Adecuación de Urgencias Hospitalarias mostró una excelente fiabilidad tanto intra como entre observadores (índices de acuerdo observado entre el 99% y 100%; estadístico kappa entre 0,97 y la unidad, y validez de criterio en el límite entre moderada y baja (índice de acuerdo observado 68%, estadístico kappa 0,39. Este bajo nivel de acuerdo se debe a que el Protocolo de Adecuación de Urgencias Hospitalarias se comporta como un instrumento muy especifico (los casos inadecuados según el juicio clínico son evaluados como inadecuados pero poco sensible (sólo el 59% de los casos que el Protocolo de Adecuación de Urgencias Hospitalarias consideró apropiados, fueron valorados de esta forma por los clínicos. CONCLUSIONES: El Protocolo de Adecuación de Urgencias

  3. Design and Construction of a Multimedia Technology Cart.

    Science.gov (United States)

    Hofstetter, Fred T.; And Others

    1993-01-01

    Describes a mobile classroom presentation cart for multimedia technology that was designed and constructed at the University of Delaware's Instructional Technology Center. Design goals are discussed; the physical layout is explained; equipment choices are described, including computer, audio system, and projection system; and future development is…

  4. Smart Shopping Carts: How Real-Time Feedback Influences Spending

    NARCIS (Netherlands)

    Ittersum, van K.; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly sho

  5. Smart shopping carts : How real-time feedback influences spending

    NARCIS (Netherlands)

    van Ittersum, Koert; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly sho

  6. Controllability of a planar inverted pendulum on a cart

    CERN Document Server

    Caiado, M Isabel

    2012-01-01

    Using tools and techniques from geometric control theory, namely Hermann-Nagano theorem, we prove controllability result for a mechanical system consisting of a planar double inverted pendulum fixed to a wheeled cart that can move linearly along a horizontal track.

  7. TEST OF AN ANIMAL DRAWN FIELD IMPLEMENT CART

    Directory of Open Access Journals (Sweden)

    Paolo Spugnoli

    2008-06-01

    Full Text Available The field performance of a horse-drawn hitch cart equipped with a PTO system powered by the two cart ground wheels have been investigated. For this purpose field tests on clay and turf soil, with varying ballast and PTO torque, have been carried out pulling the cart by a tractor. Preliminary tests were aimed at assessing the traction capability of horse breed. These tests showed that the mean draught force given by two of these horses was 173daN, average working speed was about 1m*s-1, resulting a mean draught power developed by each horse of about 0.86kW. The PTO cart system performance has shown that the torque has not exceeded 2.4daN*m, maximum draught or PTO power was 1.15kW, rotation speed just higher than 400min-1, with mean efficiency of about 50%. These values are consistent with horse performance and small haymaking, fertilizing, seeding and chemical application machine requirements.

  8. Maternal mortality due to hemorrhage in Brazil Mortalidad materna en Brasil debida a hemorragia Mortalidade materna por hemorragia no Brasil

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes de Souza

    2013-06-01

    Full Text Available OBJECTIVE: to analyze the rates of maternal mortality due to hemorrhage identified in Brazil from 1997 to 2009. Methods: the time series and population data from the Brazilian Health Ministry, Mortality Information System and Live Birth Information System were examined. From the Mortality Information System, we initially selected all reported deaths of women between 10 and 49 years old, which occurred from January 1, 1997 to December 31, 2009 in Brazil, recorded as a "maternal death". RESULTS: during the research period, 22,281 maternal deaths were identified, among which 3,179 were due to hemorrhage, accounting for 14.26% of the total deaths. The highest rates of maternal mortality were found in the North and Northeast areas of Brazil. CONCLUSIONS: the Brazilian scenario shows regional inequalities regarding maternal mortality. It presents hemorrhaging as a symptom and not as a cause of death. OBJETIVO: analizar las tasas de mortalidad materna debida a hemorragia, identificadas en Brasil durante el periodo de 1997 a 2009. MÉTODOS: fueron examinados los datos de series temporales y de población del Ministerio de la Salud de Brasil, del Sistema de Información de Mortalidad y del Sistema de Información de Nacidos Vivos. Del Sistema de Información de Mortalidad, inicialmente seleccionamos todos los informes sobre muerte de mujeres con edad entre 10 y 49 años, que ocurrieron entre el 01 de enero de 1997 y el 31 de diciembre de 2009, en Brasil, clasificadas como "muertes maternas". RESULTADOS: durante el periodo de investigación, fueron identificadas 22.281 muertes maternas, entre las cuales 3.179 se debieron a hemorragia, siendo responsables por 14,26% del total de muertes. La tasa más alta de mortalidad materna fue encontrada en las regiones Norte y Noreste de Brasil. CONCLUSIONES: el escenario brasileño muestra desigualdades regionales en lo que se refiere a mortalidad materna; este presenta la hemorragia como un síntoma y no como la

  9. Mortalidade por insuficiência cardíaca: análise ampliada e tendência temporal em três estados do Brasil Mortalidad por insuficiencia cardiaca: análisis ampliado y tendencia temporal en tres estados de Brasil Mortality due to heart failure: extended analysis and temporal trend in three states of Brazil

    Directory of Open Access Journals (Sweden)

    Eduardo Nagib Gaui

    2010-01-01

    Full Text Available FUNDAMENTO: A insuficiência cardíaca (IC é uma doença crônica de grande prevalência e altas taxas de mortalidade. A mortalidade por IC, no Brasil, tem sido estudada mais frequentemente com dados de internações hospitalares. OBJETIVO: Avaliar as taxas de mortalidade por IC, por sexo e faixa etária, no conjunto dos estados do Rio de Janeiro, São Paulo e Rio Grande do Sul, de 1999 a 2005. MÉTODOS: As informações foram obtidas dos atestados de óbito examinados nos três estados. A mortalidade por IC foi avaliada em modo restrito (causa básica de morte, modo abrangente (presente em qualquer linha do atestado e modo ampliado (todos os códigos com presença de IC. RESULTADOS: As taxas específicas de mortalidade apresentaram tendências de quedas nítidas nos grupos de idade, exceto nos de 80 anos ou mais. As taxas aumentaram com a idade, sendo maiores nos homens, de forma clara, até os 80 anos. As taxas de mortalidade por IC foram três vezes maiores no modo abrangente do que no modo restrito. O modo ampliado acrescentou ainda 20% de óbitos em que havia IC. CONCLUSÃO: Os resultados deste estudo demonstram tendências de quedas nas taxas de mortalidade por IC no conjunto dos três estados - cerca de 43% do Brasil -, de 1999 a 2005. A metodologia de causas múltiplas de morte, além das básicas, permite apresentar dimensão mais abrangente da importância da IC como causa de óbito. A seleção adequada dos códigos da Classificação Internacional de Doenças (CID, que compreendem a totalidade do fenômeno de IC, permanece como desafio para futuros estudos.FUNDAMENTO: La insuficiencia cardiaca (IC es una enfermedad crónica de gran prevalencia y altas tasas de mortalidad. La mortalidad por IC, en Brasil, se ha estudiado más frecuentemente con datos de internaciones hospitalarias. OBJETIVO: Evaluar las tasas de mortalidad por IC, por sexo e intervalo de edades, en el conjunto de los estados de Rio de Janeiro, São Paulo y Rio Grande

  10. Mortalidade feminina no período reprodutivo em localidade urbana da região sudeste do Brasil: evolução nos últimos 20 Anos

    Directory of Open Access Journals (Sweden)

    Clarisse D.G. Carvalheiro

    1992-08-01

    Full Text Available Estudou-se o comportamento da mortalidade na mulher de 15 a 49 anos, no período 1985 a 1989 comparando-o a 1970 a 1974, no Município de Ribeirão Preto, SP (Brasil. Os dados de óbitos foram obtidos nos Cartórios de Registro Civil e os de população estimados a partir dos 2 últimos censos. Analisou-se a mortalidade segundo procedência, estado civil, 7 grupos etários qüinqüenais e causas, segundo a Classificação Internacional de Doenças (9ª Revisão, 1975. Ocorreram 1.471 óbitos no período, sendo 705 os de residentes. As 4 principais causas de morte em ordem decrescente, foram: doenças do aparelho circulatório, neoplasmas, lesões e envenenamentos e doenças infecciosas e parasitárias. Os coeficientes específicos de mortalidade segundo grupos etários qüinqüenais, aumentam de modo geral com o avançar da idade, porém com valores menores que os da década anterior, particularmente aqueles codificados no Capítulo I. Os indicadores estudados mostram tendência ao declínio das doenças infecciosas e parasitárias e aumento concomitante das doenças crônico-degenerativas, ou seja, a ocorrência de uma transição epidemiológica vinculada às contradições inerentes ao estado atual de desenvolvimento do país.

  11. Mortalidade feminina no período reprodutivo em localidade urbana da região sudeste do Brasil: evolução nos últimos 20 Anos

    Directory of Open Access Journals (Sweden)

    Carvalheiro Clarisse D.G.

    1992-01-01

    Full Text Available Estudou-se o comportamento da mortalidade na mulher de 15 a 49 anos, no período 1985 a 1989 comparando-o a 1970 a 1974, no Município de Ribeirão Preto, SP (Brasil. Os dados de óbitos foram obtidos nos Cartórios de Registro Civil e os de população estimados a partir dos 2 últimos censos. Analisou-se a mortalidade segundo procedência, estado civil, 7 grupos etários qüinqüenais e causas, segundo a Classificação Internacional de Doenças (9ª Revisão, 1975. Ocorreram 1.471 óbitos no período, sendo 705 os de residentes. As 4 principais causas de morte em ordem decrescente, foram: doenças do aparelho circulatório, neoplasmas, lesões e envenenamentos e doenças infecciosas e parasitárias. Os coeficientes específicos de mortalidade segundo grupos etários qüinqüenais, aumentam de modo geral com o avançar da idade, porém com valores menores que os da década anterior, particularmente aqueles codificados no Capítulo I. Os indicadores estudados mostram tendência ao declínio das doenças infecciosas e parasitárias e aumento concomitante das doenças crônico-degenerativas, ou seja, a ocorrência de uma transição epidemiológica vinculada às contradições inerentes ao estado atual de desenvolvimento do país.

  12. Acercamiento de la expresión plástica al aula hospitalaria

    OpenAIRE

    Ramos González, Laura

    2016-01-01

    En este documento se expone el proyecto: Mis amigos los artistas, llevado a cabo en el Aula Hospitalaria situada en el Hospital General de Segovia con el fin de implementar una serie de actividades de educación plástica y observar si el concepto de arteterapia es coherente con la realidad. En una primera parte podemos encontrar el marco teórico en el que se definen y aclaran diferentes conceptos que consideramos necesarios para entender el proyecto, y en una segunda parte se...

  13. Telecontinuidad de cuidados al alta hospitalaria desde el servicio de Salud Responde

    OpenAIRE

    Fernández Carbonell, Marta; Jiménez Cobo, Marta; Millán Reyes, María Juana

    2015-01-01

    Cartel presentado en la Segunda Conferencia Internacional de Comunicación en Salud, celebrada el 23 de octubre de 2015 en la Universidad Carlos III de Madrid Introducción: la fragilidad de los pacientes pluripatológicos tras el alta hospitalaria se ha puesto de manifiesto en los estudios realizados, máxime cuando esta se produce previa a un fin de semana o periodo festivo, lo cual provoca una demora en la continuidad de cuidados hasta contactar con atención primaria. Objetivos: mejora...

  14. Remocion de la materia organica y toxicidad en aguas residuales hospitalarias aplicando ozono

    OpenAIRE

    DAYANA GRISALES PENAGOS; JOELA ORTEGA LÓPEZ; TATIANA RODRIGUEZ CHAPARRO

    2012-01-01

    Las aguas residuales hospitalarias se consideran como una de las principales fuentes de contaminantes emergentes, resultado de las diferentes actividades que allí se realizan y la excreción de las sustancias por los pacientes. Estudios han demostrado que estos componentes no son fácilmente removidos por medio de procesos de tratamiento convencionales como las plantas de tratamiento que emplean procesos biológicos. En este sentido el propósito de este trabajo consistió en evaluar la degradació...

  15. Mortalidade por leucemias relacionada à industrialização

    Directory of Open Access Journals (Sweden)

    Leal Carmen Helena Seoane

    2002-01-01

    Full Text Available OBJETIVO: Analisar a distribuição espacial da mortalidade por leucemia na população, buscando identificar agregados e estabelecer sua relação com os níveis de industrialização. MÉTODOS: O estudo foi realizado nas 43 regiões de governo do Estado de São Paulo, no qüinqüênio 1991-1995. Foi construído um "índice de industrialização relativo à leucemia" (IIRL baseado no número de indústrias e empregos industriais por 100.000 habitantes, valor adicionado fiscal, variedade de ramos industriais e indústrias com potenciais exposições de risco para a leucemia. O IIRL foi distribuído em cinco categorias. Verificaram-se os coeficientes padronizados de mortalidade por leucemia em cada uma das regiões, também distribuídos em cinco categorias e comparados ao mapa IIRL. RESULTADOS: As regiões mais industrializadas em ordem decrescente foram Campinas, Piracicaba, Jundiaí, Sorocaba e São Paulo. Não foi encontrada associação entre mortalidade, por nenhum tipo de leucemia, e industrialização. A região de Jales foi a que apresentou o mais alto coeficiente padronizado de mortalidade por leucemia. CONCLUSÕES: A distribuição da mortalidade por leucemia ocorreu de forma homogênea no Estado de São Paulo, não apresentando correlação com o nível de industrialização. Entretanto, aspectos relacionados ao método epidemiológico adotado -- estudo ecológico -- e ao uso do parâmetro "mortalidade por leucemia", doença cujo prognóstico tem mudado muito nas últimas décadas, limitaram a interpretação dos resultados.

  16. Mortalidade por leucemias relacionada à industrialização

    Directory of Open Access Journals (Sweden)

    Carmen Helena Seoane Leal

    2002-08-01

    Full Text Available OBJETIVO: Analisar a distribuição espacial da mortalidade por leucemia na população, buscando identificar agregados e estabelecer sua relação com os níveis de industrialização. MÉTODOS: O estudo foi realizado nas 43 regiões de governo do Estado de São Paulo, no qüinqüênio 1991-1995. Foi construído um "índice de industrialização relativo à leucemia" (IIRL baseado no número de indústrias e empregos industriais por 100.000 habitantes, valor adicionado fiscal, variedade de ramos industriais e indústrias com potenciais exposições de risco para a leucemia. O IIRL foi distribuído em cinco categorias. Verificaram-se os coeficientes padronizados de mortalidade por leucemia em cada uma das regiões, também distribuídos em cinco categorias e comparados ao mapa IIRL. RESULTADOS: As regiões mais industrializadas em ordem decrescente foram Campinas, Piracicaba, Jundiaí, Sorocaba e São Paulo. Não foi encontrada associação entre mortalidade, por nenhum tipo de leucemia, e industrialização. A região de Jales foi a que apresentou o mais alto coeficiente padronizado de mortalidade por leucemia. CONCLUSÕES: A distribuição da mortalidade por leucemia ocorreu de forma homogênea no Estado de São Paulo, não apresentando correlação com o nível de industrialização. Entretanto, aspectos relacionados ao método epidemiológico adotado -- estudo ecológico -- e ao uso do parâmetro "mortalidade por leucemia", doença cujo prognóstico tem mudado muito nas últimas décadas, limitaram a interpretação dos resultados.

  17. Modeling and Simulation of a Simple Cart with Low-Impact Casters

    Directory of Open Access Journals (Sweden)

    Tagami Masaharu

    2016-01-01

    Full Text Available Low-impact casters are of great importance in realizing low-crash and anti-vibration carts for a range of purposes. Here the principle of center of percussion is efficiently applied to a caster in order to suppress the transfer of crash forces to the cart from the caster. Excellent performance of this force suppression has been confirmed previously by both simulation and experiments in a single-caster cart. However, carts in real-life applications usually require four sets of casters. In this context, a mathematical model of a cart with four sets of low-impact casters was formulated. In this paper, the modeling a four-caster cart, and simulations for the cart passing over a bump are discussed.

  18. Predictors of in-hospital mortality in patients with non-variceal upper gastrointestinal bleeding Factores predictivos de mortalidad intrahospitalaria en pacientes con sangrado de tubo digestivo alto no variceal

    Directory of Open Access Journals (Sweden)

    José Alberto González-González

    2011-04-01

    paciente fue 1,6 ± 0,76. La causa más frecuente de sangrado fueron las úlceras en estómago y duodeno (55,4%; 278 pacientes (25,8% recibieron alguna forma de tratamiento endoscópico, siendo combinado en el 69,1%. Resangraron 36 pacientes (3,4% de los cuales 50% fallecieron. La mortalidad intrahospitalaria fue del 10,2%, y el 3,1% se relacionó directamente al sangrado. Al comparar la mortalidad entre pacientes con y sin comorbilidades, solo la presencia de choque hipovolémico tuvo diferencias estadísticamente significativas (48,3 vs. 25%; p = 0,020. La regresión logística mostró que el número de comorbilidades, el puntaje de Rockall, la albúmina al ingreso < 2,6 g/dl, el resangrado y la estancia hospitalaria fueron factores de riesgo independientes para mortalidad. Conclusión: el número de comorbilidades, el puntaje de Rockall, la presencia de albúmina sérica < 2,6 g/dl, el resangrado y la estancia hospitalaria son predictores de mortalidad intrahospitalaria en pacientes hispanos con STDANV.

  19. Regulation of granulosa cell cocaine and amphetamine regulated transcript (CART) binding and effect of CART signaling inhibitor on granulosa cell estradiol production during dominant follicle selection in cattle.

    Science.gov (United States)

    Folger, Joseph K; Jimenez-Krassel, Fermin; Ireland, James J; Lv, Lihua; Smith, George W

    2013-12-01

    We previously established a potential role for cocaine and amphetamine regulated transcript (CARTPT) in dominant follicle selection in cattle. CARTPT expression is elevated in subordinate versus dominant follicles, and treatment with the mature form of the CARTPT peptide (CART) decreases follicle-stimulating hormone (FSH)-stimulated granulosa cell estradiol production in vitro and follicular fluid estradiol and granulosa cell CYP19A1 mRNA in vivo. However, mechanisms that regulate granulosa cell CART responsiveness are not understood. In this study, we investigated hormonal regulation of granulosa cell CART-binding sites in vitro and temporal regulation of granulosa cell CART-binding sites in bovine follicles collected at specific stages of a follicular wave. We also determined the effect of inhibition of CART receptor signaling in vivo on estradiol production in future subordinate follicles. Granulosa cell CART binding in vitro was increased by FSH, and this induction was blocked by estrogen receptor antagonist treatment. In follicles collected in vivo at specific stages of a follicular wave, granulosa cell CART binding in the F2 (second largest), future subordinate follicle increased during dominant follicle selection. Injection into the F2 follicle (at onset of diameter deviation) of an inhibitor of the o/i subclass of G proteins (previously shown to block CART actions in vitro) resulted in increased follicular fluid estradiol concentrations in vivo. Collectively, results demonstrate hormonal regulation of granulosa cell CART binding in vitro and temporal regulation of CART binding in subordinate follicles during dominant follicle selection. Results also suggest that CART signaling may help suppress estradiol-producing capacity of the F2 (subordinate) follicle during this time period.

  20. MORTALIDAD INNECESARIAMENTE PREMATURA Y SANITARIAMENTE EVITABLE EN COSTA RICA

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    Fernando Llorca Castro

    2010-01-01

    Full Text Available Fundamentos: Para desarrollar políticas y estrategias orientadas a mitigarlas es fundamental identificar las desigualdades. El objetivo del trabajo es analizar las variaciones de la Mortalidad Innecesariamente Prematura y Sanitariamente Evitable (MIPSE para cada uno de los 81 cantones de Costa Rica durante el período 2000-2005. Métodos: Se aplicó la clasificación MIPSE propuesta por miembros del Servicio de Información y Estudios de la Dirección General de Recursos Sanitarios de Catalunya. Mediante el empleo de el Indicador de Desarrollo Socioeconómico (IDSE establecido por economistas de la Universidad de Costa Rica, previa estandarización de la población, se ordenaron los cantones en grupos por quintiles (I el más rico, Vel más pobre. Resultados: Se encontraron como causas principales de mortalidad MIPSE la enfermedad isquémica del corazón (19,55% causas MIPSE, accidentes de tránsito con vehículos a motor (11,60%, enfermedades cerebrovasculares (6,95%, perinatal (6,92% y suicidios (5,14%. Conclusión: La mortalidad por HIVy el Sida, el cáncer de mamá en mujeres, cáncer de cuerpo de útero, cáncer de piel y por hepatitis secundaria al consumo de alcohol, afectan más a los cantones con mayores ingresos. La mortalidad por hiperplasia benigna de próstata, la materna asociada al embarazo, parto o puerperio y la hernia abdominal afectan más a los de menor nivel económico. Se identificaron dos grupos de MIPSE con desigualdad equidistribuida: leucemia y enfermedades cardiovasculares congénitas.

  1. Mortalidad neonatal, análisis de registros de vigilancia e historias clínicas del año 2011 en Huánuco y Ucayali, Perú

    Directory of Open Access Journals (Sweden)

    José Enrique Velásquez Hurtado

    Full Text Available Objetivos. Estimar la tasa de mortalidad neonatal y describir las defunciones neonatales ocurridas en el 2011 en hospitales del Ministerio de Salud de las regiones Huánuco y Ucayali, Perú. Materiales y Métodos .Estudio transversal realizado de septiembre a noviembre de 2012 en Huánuco y Ucayali. Se revisaron los registros de las defunciones neonatales ocurridas en el 2011 en municipalidades provinciales, direcciones regionales de salud y cuatro hospitales de referencia. Para el cálculo de las tasas de mortalidad se utilizaron las fuentes de información más confiables por región. La revisión de 185 historias clínicas en los hospitales permitió describir las causas básicas de las muertes neonatales. Resultados. En el 2011 se reportaron en Huánuco 10 886 recién nacidos vivos y 158 muertes neonatales, con una tasa de 14,5 muertes por 1000 nacidos vivos. En Ucayali, se reportaron 11 441 recién nacidos vivos y 138 muertes neonatales, con una tasa de 12,1 muertes por 1000 nacidos vivos. La mayoría de muertes neonatales hospitalarias ocurrieron en los primeros 7 días de vida (87%, en neonatos prematuros (73,9% y con bajo peso al nacimiento (67%. Las causas básicas más frecuentes en las muertes neonatales fueron: infección (31,4%, malformación congénita (22,2% y prematuridad (18,9%. . Conclusiones La tasa de mortalidad neonatal en las regiones estudiadas fue superior a la media nacional. Los resultados sugieren la necesidad de intervenciones efectivas e integrales durante el embarazo, parto y periodo posnatal temprano; siendo este último periodo el de mayor vulnerabilidad en el neonato

  2. Mortalidad neonatal, análisis de registros de vigilancia e historias clínicas del año 2011 neonatales en Huánuco y Ucayali, Perú

    Directory of Open Access Journals (Sweden)

    José Enrique Velásquez Hurtado

    Full Text Available Objetivos. Estimar la tasa de mortalidad neonatal y describir las defunciones neonatales ocurridas en el 2011 en hospitales del Ministerio de Salud de las regiones Huánuco y Ucayali, Perú. Materiales y Métodos .Estudio transversal realizado de septiembre a noviembre de 2012 en Huánuco y Ucayali. Se revisaron los registros de las defunciones neonatales ocurridas en el 2011 en municipalidades provinciales, direcciones regionales de salud y cuatro hospitales de referencia. Para el cálculo de las tasas de mortalidad se utilizaron las fuentes de información más confiables por región. La revisión de 185 historias clínicas en los hospitales permitió describir las causas básicas de las muertes neonatales. Resultados. En el 2011 se reportaron en Huánuco 10 886 recién nacidos vivos y 158 muertes neonatales, con una tasa de 14,5 muertes por 1000 nacidos vivos. En Ucayali, se reportaron 11 441 recién nacidos vivos y 138 muertes neonatales, con una tasa de 12,1 muertes por 1000 nacidos vivos. La mayoría de muertes neonatales hospitalarias ocurrieron en los primeros 7 días de vida (87%, en neonatos prematuros (73,9% y con bajo peso al nacimiento (67%. Las causas básicas más frecuentes en las muertes neonatales fueron: infección (31,4%, malformación congénita (22,2% y prematuridad (18,9%. . Conclusiones La tasa de mortalidad neonatal en las regiones estudiadas fue superior a la media nacional. Los resultados sugieren la necesidad de intervenciones efectivas e integrales durante el embarazo, parto y periodo posnatal temprano; siendo este último periodo el de mayor vulnerabilidad en el neonato

  3. El factor de impacto de Nutrición Hospitalaria es 1,096 The impact factor of Nutrición Hospitalaria is 1.096

    Directory of Open Access Journals (Sweden)

    J. M. Culebras

    2009-08-01

    Full Text Available El director y el redactor jefe de Nutrición Hospitalaria (Nutr Hosp analizan la revista desde su fundación en 1979 hasta el momento actual, con ocasion de la primera aparición de su factor de impacto publicada por Journal Citation Reports (JCR. Se describen las acciones realizadas durante este periodo de treinta años, que incluyen su incorporación a múltiples bases de datos de la Web, la política de Open Access llevada a cabo, su progresiva internacionalización, y el análisis bibliometrico realizado en 1999. El artículo incluye un grafico con la evolución del factor de impacto. Nutr Hosp , clasificada en el grupo de "Nutrition & Dietetics" de JCR, se sitúa en la posición 42/59, es decir, en el tercer "cuartil". Entre las revistas científicas españolas indizadas en JCR, Nutr Hosp aparece en la posición14/37. Se hacen una serie de consideraciones en referencia a los aspectos económicos de la revista, el numero de artículos recibidos hasta la fecha y los que se esperan en el futuro, el porcentaje de rechazos y el idioma (español o ingles en que la revista debe ser publicada.The editors of Nutrición Hospitalaria (Nutr Hosp analyze the journal from its foundation in 1979 to the present time, on occasion of the first publication of its impact factorby Journal Citation Reports (JCR. The actions taken along this thirty year period are described, including its incorporation to multiple web databases, the Open Access policy of the journal, its progressive internationality, and the bibliometric analysis made in 1999. A figure with the journal citation trends is included. Nutr Hosp, included in the "Nutrition & Dietetics" group of JCR, is in the position 42/59, i.e. in the third quartile. Among the Spanish journals included in JCR,Nutr Hosp is located in the 14/37 position. A few considerations are made related to the economical aspects of the journal, the number of articles received so far, the articles expected in the future, the

  4. Méthodologie de Conception de Cartes Rapides Workshop

    CERN Document Server

    2003-01-01

    - Problématique de développement de carte rapide pour l'expérience LHCb(transparents) - Solution basée sur le flot Cadence PSD14.2 de conception de circuits imprimés(CI) rapides (transparents) - Nouveau partage des taches entre l'ingénieur concepteur et le professionnel développeur de CI (transparents) - Démonstration du flot à partir d'un exemple concret pour l'expérience LHCb (Démo 1h min) - Conclusion : Essentiellement pour lancer une discussion sur l'impact de ce nouveau flot de conception Cadence sur la méthode de développement de cartes à l'IN2P3.

  5. Application of CART Algorithm in Blood Donors Classification

    Directory of Open Access Journals (Sweden)

    T. Santhanam

    2010-01-01

    Full Text Available Problem statement: This study used data mining modeling techniques to examine the blood donor classification. The availability of blood in blood banks is a critical and important aspect in a healthcare system. Blood banks (in the developing countries context are typically based on a healthy person voluntarily donating blood and is used for transfusions or made into medications. The ability to identify regular blood donors will enable blood banks and voluntary organizations to plan systematically for organizing blood donation camps in an effective manner. Approach: Identify the blood donation behavior using the classification algorithms of data mining. The analysis had been carried out using a standard blood transfusion dataset and using the CART decision tree algorithm implemented in Weka. Results: Numerical experimental results on the UCI ML blood transfusion data with the enhancements helped to identify donor classification. Conclusion: The CART derived model along with the extended definition for identifying regular voluntary donors provided a good classification accuracy based model.

  6. Los determinantes de la mortalidad y las diferencias socioeconómicas de la mortalidad en la infancia

    Directory of Open Access Journals (Sweden)

    Hugo Behm Rosas

    2016-02-01

    Full Text Available PRESENTACIÓN: El texto que se reproduce a continuación, escrito por el Dr. Hugo Behm Rosas, nacido en el año 1913, a inicios de los años noventa, sintetiza lo que fue un largo y prolífico trabajo de análisis de la mortalidad infantil en América Latina. Así lo atestiguan los estudios que publicó desde los inicios de los años sesenta del siglo pasado hasta el primer lustro de este siglo. El texto: Las diferencias socioeconómicas de la mortalidad en la infancia es un capítulo del libro Las desigualdades sociales ante la muerte en América Latina publicado en el año 1992 por el Centro Latinoamericano y Caribeño de Demografía (CELADE de la Comisión Económica para América Latina y el Caribe (CEPAL y la Organización Holandesa para la Cooperación Internacional en Educación Superior. El texto constituye una síntesis de los múltiples estudios sobre diferencias de la mortalidad infantil entre grupos sociales. Las contribuciones del Dr. Behm para entender las diferencias de mortalidad infantil entre distintos grupos sociales fueron muchas. Estas empezaron cuando, como lo narra en el prólogo a una reedición de una de sus primeras publicacionesi, el Dr. Behm dejó la clínica por la salud pública para emprender una investigación sobre las diferencias de mortalidad infantil en Chile. En 1962 publicó Mortalidad infantil y nivel de vida publicado por la Escuela de Salud pública de la Universidad de Chile y recientemente reeditado por la unidad de Patrimonio Cultural de la Salud. A partir de este influyente estudio donde escribe “La mortalidad infantil viene a ser, en consecuencia, un indicador del alto precio que los pueblos pagan por las formas de organización económicamente ineficientes y socialmente injustas que han logrado darse” ii, emprendió muchos otros explorando las desigualdades sociales en la mortalidad infantil. Los últimos estudios los realizó en la subsede de CELADE en Costa Rica donde junto a muchos

  7. Zero-Spring-Rate Mechanism/Air Suspension Cart

    Science.gov (United States)

    Woodard, Stanley E.; Cooley, Victor M.

    1991-01-01

    Compact mechanism suspends articulating flexible structures with minimal constraints. Zero-spring-rate mechanism (ZSRM) air suspension cart used to suspend flexible, "mass-critical" articles like lightweight spacecraft undergoing such large motions as slewing, translation, and telescoping/retraction. Suspends flexible article undergoing large rigid-body motion concurrent with vibratory motion, with minimal interaction between suspended article and suspending hardware. Adaptive to active control, which reduces undesirable effects caused by friction, nonlinearity, and mass coupling. Practical for most suspension applications.

  8. Arquitectura hospitalaria

    OpenAIRE

    Insua Cabanas, Mercedes

    2011-01-01

    [Resumen] Estudio análisis e investigación de los hospitales de pabellones aislados gallegos, su evolución y comparación con la missma tipología en Europa y en España, así como su estudio pormenorizado.

  9. Distribution and chemical coding patterns of cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) neurons in the enteric nervous system of the porcine stomach cardia.

    Science.gov (United States)

    Rękawek, W; Sobiech, P; Gonkowski, S; Żarczyńska, K; Snarska, A; Waśniewski, T; Wojtkiewicz, J

    2015-01-01

    The aim of this study was to determine the presence of cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) neurons and co-localisation of CART with vesicular acetylcholine transporter (VAChT), neuronal nitric oxide synthase (n-NOS), vasoactive intestinal polypeptide (VIP), substance P (SP) and leu-enkephalin (LENK) in the enteric nervous system of the porcine gastric cardia by using a double-labelling immunofluorescence technique. CART-LI neurons were observed in the myenteric plexus (18.2±2.6%). A dense network of CART-LI nerve fibers was mainly observed in the muscular layer. CART showed co-localization mainly with VAChT, n-NOS, VIP and to a lesser degree with LENK and SP. Distribution of CART and its co-localization with other neurotransmitters suggest that this peptide plays an important role in gastric motility in the pig.

  10. Immunohistochemical distribution of cocaine- and amphetamine-regulated transcript peptide - like immunoreactive (CART-LI) nerve fibers and various degree of co-localization with other neuronal factors in the circular muscle layer of human descending colon.

    Science.gov (United States)

    Gonkowski, Sławomir; Kamińska, Barbara; Landowski, Piotr; Całka, Jarosław

    2013-07-01

    Cocaine- and amphetamine-regulated transcript peptide (CART) is a neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract, but knowledge about its distribution, functions and co-localisation with other neuronal factors, especially in humans, is very scarce. During the present investigation the distribution and immunohistochemical reaction (IR) of CART - like immunoreactive (CART-LI) nerve fibers in the circular muscle layer of human descending colon were studied. Fragments of human colon were processed for double labelling immunofluorescence using a mixture of anti-CART antibodies with antibodies against vesicular acetylocholine transporter (VAChT), vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase - activating peptide (PACAP), substance P (SP), galanin (GAL) and nitric oxide synthase (NOS). Thick CART-LI nerve fibers formed a very dense meshwork within the colonic circular muscle layer in all patients studied. The highest number of CART - positive nerves also contained VAChT and/or VIP. A slightly lower level of co-localisation was observed in the case of CART and PACAP or CART and NOS. Only single nerve fibers were concurrently immunoreactive to CART and SP or CART and GAL. The present study reports for the first time a detailed description of the IR of CART-LI nerve fibers in the circular muscle layer within adult human descending colon.

  11. Risco cardiovascular, efetividade e mortalidade Cardiovascular risk, effectiveness and mortality Riesgo cardiovascular, efectividad y mortalidad

    Directory of Open Access Journals (Sweden)

    Juan Gérvas

    2012-02-01

    Full Text Available

    A Lei de Ferro da Epidemiologia (Ley de Hierro de La Epidemiología diz que todos que nascem, morrem. Por isso, o propósito da Medicina não é evitar a morte por si só, mas evitar as mortes, as doenças e o sofrimento que podem ser medicamente evitáveis.

    No final, todos nossos pacientes morrerão – e nós também, obviamente, morreremos. “Os corpos encontram uma forma de morrer”, e se a causa não for por fome ou desidratação, por motivo congênito e infeccioso, por lesões, câncer ou suicídio, temos que esperar que seja por ‘motivo cardiovascular’, doença pulmonar, insuficiência renal ou hepática, demência ou outras doenças degenerativas. Mas temos que morrer por alguma coisa.

    Morrer por causa cardiovascular não é desonroso, nem refere-se à atenção clínica imperfeita. O fato de a primeira causa de morte ser a cardiovascular não tem nenhuma relação com os cuidados clínicos e nem deveria assustar.

    Entretanto, muitas das mortes por motivo cardiovascular poderiam ser evitadas. Assim, poder-se-ia evitar mortalidade cardiovascular, diminuindo a desigualdade social, por exemplo, com melhor redistribuição da riqueza, melhor educação etc. Os médicos sabem que os fatores adversos psicossociais associados ao fato de pertencer à classe baixa correspondem a 35% do risco atribuído à hipertensão na incidência do infarto do miocárdio (em outra hipótese, pertencer à classe baixa duplica 2,7 tal risco1.

    Também deve-se saber que, contra as mortes cardiovasculares, não há nada como as políticas de saúde pública quanto ao tabagismo (restrições dos lugares onde fumar, aumento do preço do tabaco, campanhas de informação, entre outras.

    Na parte clínica, as mortes cardiovasculares evitáveis devem ser vistas em perspectiva, de acordo com o que seja possível conseguir2. Portanto, por 100.000 habitantes ao ano, o tratamento com inibidores da enzima conversora de angiotensina (IECA

  12. Differential expression of CART in feeding and reward circuits in binge eating rat model.

    Science.gov (United States)

    Bharne, Ashish P; Borkar, Chandrashekhar D; Subhedar, Nishikant K; Kokare, Dadasaheb M

    2015-09-15

    Binge eating (BE) disrupts feeding and subverts reward mechanism. Since cocaine- and amphetamine-regulated transcript peptide (CART) mediates satiety as well as reward, its role in BE justifies investigation. To induce BE, rats were provided restricted access to high fat sweet palatable diet (HFSPD) for a period of 4 weeks. Immunoreactivity profile of the CART elements, and accompanying neuroplastic changes were studied in satiety- and reward-regulating brain nuclei. Further, we investigated the effects of CART, CART-antibody or rimonabant on the intake of normal chow or HFSPD. Rats fed on HFSPD showed development of BE-like phenotype as reflected by significant consumption of HFSPD in short time frame, suggestive of dysregulated satiety mechanisms. At the mid-point during BE, CART-immunoreactivity was significantly increased in hypothalamic arcuate (ARC), lateral (LH), nucleus accumbens shell (AcbSh) and paraventricular nucleus of thalamus (PVT). However, for next 22-h post-binge time-period, the animals showed no interest in food, and low CART expression. Pre-binge treatment with rimonabant, a drug recommended for the treatment of BE, produced anorexia, increased CART expression in ARC and LH, but not in AcbSh and PVT. Higher dose of CART was required to produce anorexia in binged rats. While neuronal tracing studies confirmed CART fiber connectivity from ARC and LH to AcbSh, increase in CART and synaptophysin immunostaining in this pathway in BE rats suggested strengthening of the CART connectivity. We conclude that CART bearing ARC-LH-PVT-AcbSh reward circuit may override the satiety signaling in ARC-PVN pathway in BE rats.

  13. Nicotine regulates cocaine-amphetamine-Regulated Transcript (Cart) in the mesocorticolimbic system.

    Science.gov (United States)

    Kaya, Egemen; Gozen, Oguz; Ugur, Muzeyyen; Koylu, Ersin O; Kanit, Lutfiye; Balkan, Burcu

    2016-07-01

    Cocaine-and-Amphetamine Regulated Transcript (CART) mRNA and peptides are intensely expressed in the brain regions comprising mesocorticolimbic system. Studies suggest that CART peptides may have a role in the regulation of reward circuitry. The present study aimed to examine the effect of nicotine on CART expression in the mesocorticolimbic system. Three different doses of nicotine (0.2, 0.4, 0.6 mg/kg free base) were injected subcutaneously for 5 days, and on day 6, rats were decapitated following a challenge dose. CART mRNA and peptide levels in medial prefrontal cortex (mPFC), nucleus accumbens (NAc), dorsal striatum (DST), amygdala (AMG), lateral hypothalamic area (LHA), and ventral tegmental area (VTA) were measured by quantitative real-time PCR (qPCR) and Western Blot analysis, respectively. In the mPFC, 0.4 and 0.6 mg/kg nicotine, decreased CART peptide levels whereas there was no effect on CART mRNA levels. In the VTA, a down-regulation of CART peptide expression was observed with 0.2 and 0.6 mg/kg nicotine. Conversely, 0.4 and 0.6 mg/kg nicotine increased CART mRNA levels in the AMG without affecting the CART peptide expression. Nicotine did not regulate CART mRNA or CART peptide expression in the NAc, DST, and LHA. We conclude that nicotine regulates CART expression in the mesocorticolimbic system and this regulation may play an important role in nicotine reward. Synapse 70:283-292, 2016. © 2016 Wiley Periodicals, Inc.

  14. [The impact factor of Nutrición Hospitalaria is 1.096].

    Science.gov (United States)

    Culebras, J M; García de Lorenzo, A

    2009-01-01

    The editors of Nutrición Hospitalaria (Nutr Hosp) analyze the journal from its foundation in 1979 to the present time, on occasion of the first publication of its impact factorby Journal Citation Reports (JCR). The actions taken along this thirty year period are described, including its incorporation to multiple web databases, the Open Access policy of the journal, its progressive internationality, and the bibliometric analysis made in 1999. A figure with the journal citation trends is included. Nutr Hosp, included in the "Nutrition & Dietetics" group of JCR, is in the position 42/59, i.e. in the third quartile. Among the Spanish journals included in JCR,Nutr Hosp is located in the 14/37 position. A few considerations are made related to the economical aspects of the journal, the number of articles received so far, the articles expected in the future, the rejection rate and the language (Spanish or English) in which Nutr Hosp should be published.

  15. Infant mortality in three population-based cohorts in Southern Brazil: trends and differentials Mortalidade infantil em três coortes de base populacional no Sul do Brasil: tendências e diferenciais

    Directory of Open Access Journals (Sweden)

    Iná S. Santos

    2008-01-01

    Full Text Available We studied time trends in infant mortality and associated factors between three cohort studies carried out in Pelotas, Rio Grande do Sul State, Brazil, in 1982, 1993, and 2004. All hospital births and deaths were determined by means of regular visits to hospitals, registrar's offices, and cemeteries. This data was used to calculate neonatal, post-neonatal, and infant mortality rates per thousand live births. Rates were also calculated according to cause of death, sex, birth weight, gestational age, and family income. The infant mortality rate fell from 36.4 per 1,000 live births in 1982 to 21.1 in 1993 and 19.4 in 2004. Major causes of infant mortality in 2004 were perinatal causes and respiratory infections. Mortality among low birth weight children from poor families fell 16% between 1993 and 2004; however, this rate increased by more than 100% among high-income families due to the increase in the number of preterm deliveries in this group. The stabilization of infant mortality in the last decade is likely to be due to excess medical interventions relating to pregnancies and delivery care.Os autores estudaram tendências temporais nas taxas de mortalidade infantil e fatores associados em três coortes em Pelotas, Rio Grande do Sul, Brasil, de 1982, 1993 e 2004. Todos os nascimentos hospitalares e óbitos foram identificados através de visitas regulares aos hospitais, cartórios e cemitérios. Esses dados foram utilizados para calcular as taxas de mortalidade neonatal, pós-neonatal e infantil por mil nascidos vivos. Também foram calculadas as taxas específicas de acordo com causa de óbito, sexo, peso ao nascer, idade gestacional e renda familiar. O coeficiente de mortalidade infantil diminuiu de 36,4 por mil nascidos vivos em 1982 para 21,1 em 1993 e 19,4 em 2004. As principais causas de mortalidade infantil em 2004 foram causas perinatais e infecções respiratórias. Entre 1993 e 2004, houve uma redução de 16% na mortalidade entre

  16. REMOCION DE LA MATERIA ORGANICA Y TOXICIDAD EN AGUAS RESIDUALES HOSPITALARIAS APLICANDO OZONO

    Directory of Open Access Journals (Sweden)

    DAYANA GRISALES PENAGOS

    2012-01-01

    Full Text Available Las aguas residuales hospitalarias se consideran como una de las principales fuentes de contaminantes emergentes, resultado de las diferentes actividades que allí se realizan y la excreción de las sustancias por los pacientes. Estudios han demostrado que estos componentes no son fácilmente removidos por medio de procesos de tratamiento convencionales como las plantas de tratamiento que emplean procesos biológicos. En este sentido el propósito de este trabajo consistió en evaluar la degradación de la materia orgánica presente en aguas hospitalarias reales aplicando ozono en diferentes condiciones de pH (3,0, 6,7, 10. Para esto se analizaron los valores de la UV254, la relación de biodegradabilidad DQO/DBO5 y el color (VIS436. Adicional a esto, se realizó un ensayo de toxicidad aguda, utilizando bulbos de cebolla común (Allium cepa L. Los resultados mostraron que con una dosis aplicada de ozono de 187 mgO3/h y valores de pH=10 la biodegradabilidad se aumento en un 70% y la toxicidad aguda se redujo en 62%, mientras que para valores de pH =3,0, se favoreció la remoción de la UV254 y el color. La aplicación de ozono demostró ser una alternativa viable para tratar efluentes hospitalarios como pretratamiento de un proceso biológico.

  17. CART treatment improves memory and synaptic structure in APP/PS1 mice.

    Science.gov (United States)

    Jin, Jia-li; Liou, Anthony K F; Shi, Yejie; Yin, Kai-lin; Chen, Ling; Li, Ling-ling; Zhu, Xiao-lei; Qian, Lai; Yang, Rong; Chen, Jun; Xu, Yun

    2015-05-11

    Major characteristics of Alzheimer's disease (AD) include deposits of β-amyloid (Aβ) peptide in the brain, loss of synapses, and cognitive dysfunction. Cocaine- and amphetamine-regulated transcript (CART) has recently been reported to attenuate Aβ-induced toxicity. In this study, CART localization in APP/PS1 mice was characterized and the protective effects of exogenous CART treatment were examined. Compared to age-matched wild type mice, 8-month-old APP/PS1 mice had significantly greater CART immunoreactivity in the hippocampus and cortex. A strikingly similar pattern of Aβ plaque-associated CART immunoreactivity was observed in the cortex of AD cases. Treatment of APP/PS1 mice with exogenous CART ameliorated memory deficits; this effect was associated with improvements in synaptic ultrastructure and long-term potentiation, but not a reduction of the Aβ plaques. Exogenous CART treatment in APP/PS1 mice prevented depolarization of the mitochondrial membrane and stimulated mitochondrial complex I and II activities, resulting in an increase in ATP levels. CART treatment of APP/PS1 mice also reduced reactive oxygen species and 4-hydroxynonenal, and mitigated oxidative DNA damage. In summary, CART treatment reduced multiple neuropathological measures and improved memory in APP/PS1 mice, and may therefore be a promising and novel therapy for AD.

  18. Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.

    Science.gov (United States)

    Salinas, Armando G; Nguyen, Chinh T Q; Ahmadi-Tehrani, Dara; Morrisett, Richard A

    2014-03-01

    Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide implicated in addiction to drugs of abuse. Several studies have characterized the role of CART in addiction to psychostimulants, but few have examined the role of CART in alcohol use disorders including alcoholism. The current study utilized a CART knockout (KO) mouse model to investigate the role of CART in ethanol appetitive behaviors. A two-bottle choice, unlimited-access paradigm was used to compare ethanol appetitive behaviors between CART wild type (WT) and KO mice. The mice were presented with an ethanol solution (3%-21%) and water, each concentration for 4 days, and their consumption was measured daily. Consumption of quinine (bitter) and saccharin (sweet) solutions was measured following the ethanol preference tests. In addition, ethanol metabolism rates and ethanol sensitivity were compared between genotypes. CART KO mice consumed and preferred ethanol less than their WT counterparts in both sexes. This genotype effect could not be attributed to differences in bitter or sweet taste perception or ethanol metabolism rates. There was also no difference in ethanol sensitivity in male mice; however, CART KO female mice showed a greater ethanol sensitivity than the WT females. Taken together, these data demonstrate a role for CART in ethanol appetitive behaviors and as a possible therapeutic drug target for alcoholism and abstinence enhancement.

  19. Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.

    Science.gov (United States)

    Sathanoori, Ramasri; Olde, Björn; Erlinge, David; Göransson, Olga; Wierup, Nils

    2013-02-01

    Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide that promotes glucose-stimulated insulin secretion in beta cells via cAMP/PKA-dependent pathways. In addition, CART is a regulator of neuronal survival. In this study, we examined the effect of exogenous CART 55-102 on beta cell viability and dissected its signaling mechanisms. Evaluation of DNA fragmentation and chromatin condensation revealed that CART 55-102 reduced glucotoxicity-induced apoptosis in both INS-1 (832/13) cells and isolated rat islets. Glucotoxicity in INS-1 (832/13) cells also caused a 50% reduction of endogenous CART protein. We show that CART increased proliferation in INS-1 (832/13) cells, an effect that was blocked by PKA, PKB, and MEK1 inhibitors. In addition, CART induced phosphorylation of CREB, IRS, PKB, FoxO1, p44/42 MAPK, and p90RSK in INS-1 (832/13) cells and isolated rat islets, all key mediators of cell survival and proliferation. Thus, we demonstrate that CART 55-102 protects beta cells against glucotoxicity and promotes proliferation. Taken together our data point to the potential use of CART in therapeutic interventions targeted at enhancing functional beta cell mass and long-term insulin secretion in T2D.

  20. CART treatment improves memory and synaptic structure in APP/PS1 mice

    Science.gov (United States)

    Jin, Jia-li; Liou, Anthony K.F.; Shi, Yejie; Yin, Kai-lin; Chen, Ling; Li, Ling-ling; Zhu, Xiao-lei; Qian, Lai; Yang, Rong; Chen, Jun; Xu, Yun

    2015-01-01

    Major characteristics of Alzheimer’s disease (AD) include deposits of β-amyloid (Aβ) peptide in the brain, loss of synapses, and cognitive dysfunction. Cocaine- and amphetamine-regulated transcript (CART) has recently been reported to attenuate Aβ-induced toxicity. In this study, CART localization in APP/PS1 mice was characterized and the protective effects of exogenous CART treatment were examined. Compared to age-matched wild type mice, 8-month-old APP/PS1 mice had significantly greater CART immunoreactivity in the hippocampus and cortex. A strikingly similar pattern of Aβ plaque-associated CART immunoreactivity was observed in the cortex of AD cases. Treatment of APP/PS1 mice with exogenous CART ameliorated memory deficits; this effect was associated with improvements in synaptic ultrastructure and long-term potentiation, but not a reduction of the Aβ plaques. Exogenous CART treatment in APP/PS1 mice prevented depolarization of the mitochondrial membrane and stimulated mitochondrial complex I and II activities, resulting in an increase in ATP levels. CART treatment of APP/PS1 mice also reduced reactive oxygen species and 4-hydroxynonenal, and mitigated oxidative DNA damage. In summary, CART treatment reduced multiple neuropathological measures and improved memory in APP/PS1 mice, and may therefore be a promising and novel therapy for AD. PMID:25959573

  1. Relaparotomía a demanda. Factores asociados a mortalidad

    OpenAIRE

    José Luis Martínez-Ordaz; Roberto Manuel Suárez-Moreno; Óscar Javier Felipez-Aguilar; Roberto Blanco-Benavides

    2005-01-01

    Objetivo: revisar los factores asociados con la mortalidad de los pacientes sometidos a relaparotomía a demanda. Introducción: algunos pacientes sometidos a laparotomía son reintervenidos debido a complicaciones agudas. Pueden ser manejados de manera programada o conforme su evolución. Todavía no está determinado cuál de los dos abordajes es mejor. Material y métodos: 33 pacientes fueron relaparotomizados a demanda en un servicio de cirugía general. Resultados: en total se realizaron 51 relap...

  2. MORTALIDAD INNECESARIAMENTE PREMATURA Y SANITARIAMENTE EVITABLE EN COSTA RICA

    OpenAIRE

    Fernando Llorca Castro; Vicente Ortún Rubio

    2010-01-01

    Fundamentos: Para desarrollar políticas y estrategias orientadas a mitigarlas es fundamental identificar las desigualdades. El objetivo del trabajo es analizar las variaciones de la Mortalidad Innecesariamente Prematura y Sanitariamente Evitable (MIPSE) para cada uno de los 81 cantones de Costa Rica durante el período 2000-2005. Métodos: Se aplicó la clasificación MIPSE propuesta por miembros del Servicio de Información y Estudios de la Dirección General de Recursos Sanitarios de Catalunya. M...

  3. Hijo de madre adolescente: riesgos, morbilidad y mortalidad neonatal

    OpenAIRE

    2012-01-01

    Antecedentes: El embarazo en adolescentes es un problema de salud pública por las consecuencias para el binomio madre-hijo. Objetivo: Determinar las características y riesgos en madres adolescentes y sus hijos (antropometría, condición de nacimiento y morbi-mortalidad), en comparación con un grupo de madres adultas control de 20-34 años. Métodos: Estudio de cohorte prospectiva con 379 hijos de mujeres adolescentes y 928 adultas. Los datos fueron analizados empleando mediana, promedio y medida...

  4. MORBILIDAD Y MORTALIDAD NEONATAL ASOCIADA A LA DIABETES GESTACIONAL

    OpenAIRE

    Velázquez G,Pablo; Vega M,Genaro; Martínez M,Martha Leticia

    2010-01-01

    Objetivo: Determinar la asociación de la morbilidad y mortalidad neonatal con la diabetes gestacional. Método: Estudio tipo cohortes. Se realizó un estudio en embarazadas desde diciembre de 2007 a noviembre de 2008 en el servicio de tococirugía del Hospital General Regional No. 1 de Querétaro, México, se formaron dos grupos de 71 pacientes, uno con diabetes gestacional y otro sin ella. El muestreo fue por cuota pareado por edad. En ambos grupos se midieron variables sociodemográficas, anteced...

  5. The use of a cutting balloon in contemporary reverse controlled antegrade and retrograde subintimal tracking (reverse CART) technique.

    Science.gov (United States)

    Nakabayashi, Keisuke; Okada, Hisayuki; Oka, Toshiaki

    2016-07-11

    The key concept of reverse controlled antegrade and retrograde tracking (CART) technique is retrograde puncture with a tapered wire to an antegrade balloon (contemporary reverse CART) or new connections between the antegrade and retrograde subintimal space (classical reverse CART). In our case, a 75-year-old man with severe chronic total occlusion of the right coronary artery, reverse CART with conventional balloons could not be accomplished. Externalization wiring was completed by contemporary reverse CART using a cutting balloon as an antegrade balloon to improve the fenestration force of the retrograde guidewire. Thus, the use of a cutting balloon for contemporary reverse CART might be promising.

  6. CryoCart Restoration and Vacuum Pipe Construction

    Science.gov (United States)

    Chaidez, Mariana

    2016-01-01

    first completed at the component level. During this process, the igniter of the main engine and the RCS thrusters will be tested under a vacuum. To complete the testing of the components, the test setup first needed to be finalized. The CryoCart is being used to feed the propellants to the test article. The CryoCart is a movable test set-up that was developed in 2009 to provide a mobile platform for testing oxygen/methane systems with hot-fire capability up to 100 lbf. The CryoCart consists of three different systems: Oxygen, Methane, and liquid Nitrogen. The Oxygen and Methane systems are placed into two different carts while the liquid nitrogen system is mainly located in the methane cart. Over the years, the CryoCart has been utilized for different projects and has undergone deterioration. For this reason, a new phase has been developed to rebuild it to working conditions once again. During my internship, I was aiding in the construction and restoration of the CryoCart. In the initial stages of the process, I updated the fluid and electrical schematics for the oxygen, methane, and test article systems. The original CryoCart consisted of an electrical panel that utilized electromechanical relays and a terminal to drive the igniter power and signal, as well as the main fuel and oxygen valves. This electrical panel connected to the CryoCart through various wire harnesses that could be found exiting from the CryoCart. First, it was determined how these harnesses connected to the electromechanical relays so that they worked correctly. Once the electrical system was understood, an alternative for the electromechanical relays and the Molex connectors used throughout the system was sought since these components can often prove to be unreliable. Solid State relays and MIL connectors were purchased to serve as replacements. Upon arrival of the parts, crimping and wiring was completed to install the new solid state relays and MIL connectors. During the replacement of the relays

  7. CART modulates the effects of levodopa in rat model of Parkinson's disease.

    Science.gov (United States)

    Upadhya, Manoj A; Shelkar, Gajanan P; Subhedar, Nishikant K; Kokare, Dadasaheb M

    2016-03-15

    Parkinson's disease (PD) is an age-related disorder characterized by a progressive degeneration of dopaminergic neurons of substantia nigra (SN). The neuropeptide cocaine- and amphetamine-regulated transcript (CART) is known to closely interact with the dopamine system and regulate psychomotor activity. We screened the effectiveness of CART in reversing the symptoms of PD in a rat model. PD like condition was induced by administering 6-hydroxydopamine (6-OHDA) directly in the SN of the right side. Fifteen days later, intraperitoneal (IP) treatment with apomorphine hydrochloride to these rats, resulted in contralateral rotations in the rotation test chamber suggesting induction of PD-like symptoms. This action of apomorphine was significantly attenuated by intracerebroventricular (ICV) treatment with CART and potentiated by CART antibody. IP treatment with levodopa also produced contralateral rotation in PD induced rats, and showed anti-Parkinson-like action. Prior treatment with CART via ICV route potentiated the anti-Parkinsonian effects of levodopa, while CART antibody produced opposite effects. CART treatment per se, to PD induced rats produced ipsilateral rotations, suggesting that the peptide may promote the endogenous release of dopamine from intact neurons. While CART-immunoreactivity in arcuate nucleus, paraventricular nucleus, striatum, substantia nigra, ventral tegmental area and locus coeruleus was reduced in the PD induced rats, levodopa treatment restored the expression of CART-immunoreactivity in these nuclei. These results suggest that endogenous CART might closely interact with the dopamine containing SN-striatal pathway which is known to profoundly influence the motor system. The study underscores the importance of CART as a potential therapeutic agent in the treatment of PD.

  8. E-Commerce Performance. Shopping Cart Key Performance Indicators

    Directory of Open Access Journals (Sweden)

    Mihaela I. MUNTEAN

    2016-01-01

    Full Text Available In an e-commerce performance framework is important to identify the key performance indicators that measure success and together provide the greatest context into the business perfor-mance. Shopping carts are an essential part of ecommerce, a minimal set of key performance indicators being the subject of our debate. The theoretical approach is sustained by a case study, an e-shop implemented using PHP and MySQL, for simulating main business processes within the considered performance framework. Our approach opens a perspective for future research using additional indicators in order to properly evaluate the global performance of any e-shop.

  9. Perfil de la mortalidad de hembras de Rhodnius robustus (Heteroptera: Reduviidae

    Directory of Open Access Journals (Sweden)

    Chaves Luis Fernando

    2004-01-01

    Full Text Available Se estudió la mortalidad de 48 hembras adultas de Rhodnius robustus. Dada la significancia estadística del ajuste de los datos al modelo de Gompertz (p<0.0001, se puede afirmar que el mismo permite describir la mortalidad de esta especie.

  10. AZ-101 Mixer Pump Demonstration Data Acquisition System and Gamma Cart Data Acquisition Control System Software Configuration Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    WHITE, D.A.

    1999-12-29

    This Software Configuration Management Plan (SCMP) provides the instructions for change control of the AZ1101 Mixer Pump Demonstration Data Acquisition System (DAS) and the Sludge Mobilization Cart (Gamma Cart) Data Acquisition and Control System (DACS).

  11. Identification of the CART neuropeptide circuitry processing TMT-induced predator stress.

    Science.gov (United States)

    Sharma, Anju; Rale, Abhishek; Utturwar, Kaweri; Ghose, Aurnab; Subhedar, Nishikant

    2014-12-01

    Abundance of cocaine- and amphetamine-regulated transcript (CART) neuropeptide in the limbic areas like the olfactory system, central nucleus of amygdala (CeA), ventral bed nucleus of stria terminalis (vBNST) and the hypothalamus suggests involvement of the peptide in emotive processing. We examined the role of CART in mediating fear, a strong emotion with profound survival value. Rats, exposed to 2,4,5-trimethyl-3-thiazoline (TMT), a predator related cue extracted from fox feces, showed significant increase in freezing, escape and risk assessment behavior, whereas grooming was reduced. Neuronal activity was up-regulated in the CeA and vBNST in terms of increased immunoreactivity in CART elements and c-Fos expression. Increased expression of both the markers was also seen in some discrete magnocellular as well as parvicellular subdivisions of the paraventricular nucleus (PVN). However, CART containing mitral cells in the main or accessory olfactory bulb did not respond. CART antibody was stereotaxically injected bilaterally into the CeA to locally immunoneutralize endogenous CART. On exposure to TMT, these rats showed reduced freezing, risk assessment and escape behavior while grooming was restored to normal value. We suggest that the CART signaling in the CeA and vBNST, but not in the olfactory system, might be an important component of the innate fear processing, and expression of stereotypic behavior, while CART in the PVN subdivisions might mediate the neuroendocrine response to predator stress.

  12. Distribution pattern of CART-containing neurons and cells in the human pancreas.

    Science.gov (United States)

    Kasacka, Irena; Janiuk, Izabela; Lewandowska, Alicja; Bekisz, Agnieszka; Lebkowski, Wojciech

    2012-11-01

    Cocaine- and amphetamine-regulated transcript (CART) has been shown to play a critical role in appetite suppression, cell survival, thermoregulation, glucose sensing, stimulation of hormone secretion, as well as for the regulatory function of the islets of Langerhans. Although the principal site of CART synthesis has already been reported, our knowledge of the subject is mainly based on and limited to research conducted on animals owing to difficulties in obtaining human samples. Therefore, the primary goal of the reported study was an attempt to identify and localize CART in healthy human pancreas. Nineteen deceased subjects (donors of organs) with normal pancreas and alimentary tract were used in the study. After determination of brain death and confirmation of death by the relevant doctors committee, pancreas samples, about 1cm long, were collected from each corpse (the same part of the pancreas) after the organs were harvested for transplantation. Paraffin sections were made and stained with hematoxylin and eosin and then subjected to CART immunohistochemistry. In the normal pancreas of human adults, CART is mainly present in both nerve fibers and in nerve cell bodies in pancreatic ganglia. In addition to pancreatic neurons, immunoreactivity to CART was also seen in islet endocrine cells. This is the first report on the presence of CART-IR structures in the normal human pancreas. CART should be now added to the numerous regulatory peptides that are involved in the complex regulation of pancreatic endocrine and exocrine processes.

  13. Stability of CART peptide expression in the nucleus accumbens in aging.

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    Armbruszt, Simon; Figler, Mária; Ábrahám, Hajnalka

    2015-03-01

    Aging is accompanied by changes of several anorexigenic and orexigenic neuropeptides expressed in various brain areas that control food intake and these changes correlate with senescent anorexia. During aging expression of cocaine- and amphetamine-regulated transcript (CART) peptide was reported to be reduced in the hypothalamic nuclei related to food intake. Although CART peptide is abundant in the nucleus accumbens that also plays a crucial role in the food intake regulation, no data is available about the CART peptide expression in this region through aging. In the present study, CART peptide immunoreactivity was compared in the nucleus accumbens of young adult (4- and 7-month-old) middle-aged (15-month-old) and aging (25-32-month-old) Long-Evans rats. The density of CART-immunoreactive cells and axon terminals in the nucleus accumbens was measured with computer-aided densitometry. CART-immunodensity was similar in the old rats and in the younger animals without significant difference between age groups. In addition, no gender-difference was observed when CART-immunoreactivities in the nucleus accumbens of male and female animals were compared. Our results indicate that CART peptide expression in the nucleus accumbens is stable in adults and does not change with age.

  14. Identification and location of the cocaine and amphetamine regulated transcript (CART) in the abomasum of cattle.

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    Janiuk, Izabela; Młynek, Krzysztof; Wysocki, Jarosław

    2013-05-01

    The cocaine and amphetamine regulated transcript (CART) belongs to the group of peptides with anorexigenic properties and is present in many areas of the central and peripheral nervous systems of numerous mammalian species. Research has suggested an effect on the feeling of appetite and satiety; however, there are no clear clues as to the role of CART in specific organs, including the stomach. Considering the specificity of cattle feeding and digestion, CART may play a highly significant role possibly associated with the option of administering greater amounts of high-volume feeds. Based on the results of immunohistochemical staining of abomasum samples prepared from hybrid bulls, the presence of CART-positive structures and CART distribution were determined in the mucosa, submucosa and muscularis layers of the stomach. Abundant sites of CART were found in the myenteric plexus, nerve fibers innervating the myocytes of the myenteron, neuroendocrine cells of the diffuse neuroendocrine system and the submucous plexus. The preliminary stage of abomasal CART detection suggests that CART is an agent that strongly affects the regulation of motor activity involved in stomach emptying and in secretory functions of the stomach. However, further research is necessary to explain the relationship.

  15. The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling.

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    Stenesen, Drew; Moehlman, Andrew T; Krämer, Helmut

    2015-12-14

    Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by uptake into glia and conversion into carcinine, which functions as transport metabolite. How carcinine is transported from glia to photoreceptor neurons remains unclear. In a targeted RNAi screen for genes involved in this pathway, we identified carT, which encodes a member of the SLC22A transporter family. CarT expression in photoreceptors is necessary and sufficient for fly vision and behavior. Carcinine accumulates in the lamina of carT flies. Wild-type levels are restored by photoreceptor-specific expression of CarT, and endogenous tagging suggests CarT localizes to synaptic endings. Heterologous expression of CarT in S2 cells is sufficient for carcinine uptake, demonstrating the ability of CarT to utilize carcinine as a transport substrate. Together, our results demonstrate that CarT transports the histamine metabolite carcinine into photoreceptor neurons, thus contributing an essential step to the histamine-carcinine cycle.

  16. CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria.

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    Peizhong Mao

    Full Text Available The multifunctional neuropeptide Cocaine and Amphetamine Regulated Transcript (CART is secreted from hypothalamus, pituitary, adrenal gland and pancreas. It also can be found in circulatory system. This feature suggests a general role for CART in different cells. In the present study, we demonstrate that CART protects mitochondrial DNA (mtDNA, cellular proteins and lipids against the oxidative action of hydrogen peroxide, a widely used oxidant. Using cis-parinaric acid as a sensitive reporting probe for peroxidation in membranes, and a lipid-soluble azo initiator of peroxyl radicals, 2,2'-azobis(2,4-dimethylvaleronitrile we found that CART is an antioxidant. Furthermore, we found that CART localized to mitochondria in cultured cells and mouse brain neuronal cells. More importantly, pretreatment with CART by systemic injection protects against a mouse oxidative stress model, which mimics the main features of Parkinson's disease. Given the unique molecular structure and biological features of CART, we conclude that CART is an antioxidant peptide (or antioxidant hormone. We further propose that it may have strong therapeutic properties for human diseases in which oxidative stress is strongly involved such as Parkinson's disease.

  17. The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling

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    Stenesen, Drew; Moehlman, Andrew T; Krämer, Helmut

    2015-01-01

    Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by uptake into glia and conversion into carcinine, which functions as transport metabolite. How carcinine is transported from glia to photoreceptor neurons remains unclear. In a targeted RNAi screen for genes involved in this pathway, we identified carT, which encodes a member of the SLC22A transporter family. CarT expression in photoreceptors is necessary and sufficient for fly vision and behavior. Carcinine accumulates in the lamina of carT flies. Wild-type levels are restored by photoreceptor-specific expression of CarT, and endogenous tagging suggests CarT localizes to synaptic endings. Heterologous expression of CarT in S2 cells is sufficient for carcinine uptake, demonstrating the ability of CarT to utilize carcinine as a transport substrate. Together, our results demonstrate that CarT transports the histamine metabolite carcinine into photoreceptor neurons, thus contributing an essential step to the histamine–carcinine cycle. DOI: http://dx.doi.org/10.7554/eLife.10972.001 PMID:26653853

  18. Fibrilación auricular en los servicios de urgencias hospitalarias

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    García Palacios, José David

    2016-01-01

    La fibrilación auricular (FA) es la arritmia cardíaca sostenida más frecuente en la población. Es una enfermedad grave y es un factor predictivo independiente de mortalidad, asociando un riesgo de ictus 5 veces superior a la población general. Los SUH constituyen la “puerta de entrada” al sistema sanitario para la población, de ahí la importancia de un adecuado manejo. Tipo de estudio: descriptivo transversal retrospectivo. Ámbito del estudio: Servicio de Urgencias de un hospital de tercer...

  19. Injection of Cocaine-Amphetamine Regulated Transcript (CART) peptide into the nucleus accumbens does not inhibit caffeine-induced locomotor activity: Implications for CART peptide mechanism.

    Science.gov (United States)

    Job, Martin O

    2016-09-01

    Much evidence suggests that intra-nucleus accumbens (NAc) CART peptide (CART 55-102) injection inhibits locomotor activity (LMA) when there is an increase in the release and activity of dopamine (DA) in the NAc. However, this hypothesis has not been fully tested. One way to examine this is to determine if there is a lack of effect of intra-NAc CART peptide on LMA that does not involve increases in DA release in the NAc. Several studies have suggested that caffeine-induced LMA does not involve extracellular DA release in the NAc core. Therefore, in this study, we have examined the effect of injections of CART peptide (2.5μg) into the NAc core on the locomotor effects of caffeine in male Sprague-Dawley rats. Several LMA relevant doses of caffeine were used (0, 10, 20mg/kg i.p.), and an inverted U response curve was found as expected. We determined, in the same animals, that intra-NAc CART peptide had no effect on caffeine-induced LMA whereas it blunted cocaine-mediated LMA, as shown by other reports. We also extended a previous observation in mice by showing that at a LMA activating dose of caffeine there is no alteration of CART peptide levels in the NAc of rats. Our study supports the hypothesis that the inhibitory effects of CART peptide in the NAc may be exerted only under conditions of increased extracellular DA release and activity in this region. Our results also suggest that intra-NAc CART 55-102 does not generally inhibit increases in LMA due to all drugs, but has a more specific inhibitory effect on dopaminergic neurotransmission.

  20. Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV.

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    Victor G Valcour

    Full Text Available To compare central nervous system (CNS outcomes in participants treated during acute HIV infection with standard combination antiretroviral therapy (cART vs. cART plus integrase inhibitor and CCR5 antagonist (cART+.24-week randomized open-label prospective evaluation.Participants were evaluated then randomized to initiate cART (efavirenz, tenofovir, and either emtricitabine or lamivudine vs. cART+ (cART plus raltegravir and maraviroc during acute HIV and re-evaluated at 4, 12 and 24 weeks. We examined plasma and CSF cytokines, HIV RNA levels, neurological and neuropsychological findings, and brain MRS across groups and compared to healthy controls.At baseline, 62 participants were in Fiebig stages I-V. Randomized groups were similar for mean age (27 vs. 25, p = 0.137, gender (each 94% male, plasma log10 HIV RNA (5.4 vs. 5.6, p = 0.382, CSF log10 HIV RNA (2.35 vs. 3.31, p = 0.561, and estimated duration of HIV (18 vs. 17 days, p = 0.546. Randomized arms did not differ at 24 weeks by any CNS outcome. Combining arms, all measures concurrent with antiretroviral treatment improved, for example, neuropsychological testing (mean NPZ-4 of -0.408 vs. 0.245, p<0.001 and inflammatory markers by MRS (e.g. mean frontal white matter (FWM choline of 2.92 vs. 2.84, p = 0.045 at baseline and week 24, respectively. Plasma neopterin (p<0.001 and interferon gamma-induced protein 10 (IP-10 (p = 0.007 remained elevated in participants compared to controls but no statistically significant differences were seen in CSF cytokines compared to controls, despite individual variability among the HIV-infected group.A 24-week course of cART+ improved CNS related outcomes, but was not associated with measurable differences compared to standard cART.

  1. Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV

    Science.gov (United States)

    Valcour, Victor G.; Spudich, Serena S.; Sailasuta, Napapon; Phanuphak, Nittaya; Lerdlum, Sukalaya; Fletcher, James L. K.; Kroon, Eugene D. M. B.; Jagodzinski, Linda L.; Allen, Isabel E.; Adams, Collin L.; Prueksakaew, Peeriya; Slike, Bonnie M.; Hellmuth, Joanna M.; Kim, Jerome H.; Ananworanich, Jintanat

    2015-01-01

    Objective To compare central nervous system (CNS) outcomes in participants treated during acute HIV infection with standard combination antiretroviral therapy (cART) vs. cART plus integrase inhibitor and CCR5 antagonist (cART+). Design 24-week randomized open-label prospective evaluation. Method Participants were evaluated then randomized to initiate cART (efavirenz, tenofovir, and either emtricitabine or lamivudine) vs. cART+ (cART plus raltegravir and maraviroc) during acute HIV and re-evaluated at 4, 12 and 24 weeks. We examined plasma and CSF cytokines, HIV RNA levels, neurological and neuropsychological findings, and brain MRS across groups and compared to healthy controls. Results At baseline, 62 participants were in Fiebig stages I-V. Randomized groups were similar for mean age (27 vs. 25, p = 0.137), gender (each 94% male), plasma log10 HIV RNA (5.4 vs. 5.6, p = 0.382), CSF log10 HIV RNA (2.35 vs. 3.31, p = 0.561), and estimated duration of HIV (18 vs. 17 days, p = 0.546). Randomized arms did not differ at 24 weeks by any CNS outcome. Combining arms, all measures concurrent with antiretroviral treatment improved, for example, neuropsychological testing (mean NPZ-4 of -0.408 vs. 0.245, p<0.001) and inflammatory markers by MRS (e.g. mean frontal white matter (FWM) choline of 2.92 vs. 2.84, p = 0.045) at baseline and week 24, respectively. Plasma neopterin (p<0.001) and interferon gamma-induced protein 10 (IP-10) (p = 0.007) remained elevated in participants compared to controls but no statistically significant differences were seen in CSF cytokines compared to controls, despite individual variability among the HIV-infected group. Conclusions A 24-week course of cART+ improved CNS related outcomes, but was not associated with measurable differences compared to standard cART. PMID:26555069

  2. Birmanie-Thaïlande: un écart croissant

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    Michel BRUNEAU

    1991-03-01

    Full Text Available Deux royaumes (Birmanie et Siam très proches l’un de l’autre culturellement et dans leurs structures socio-politiques ont vu, au cours des deux siècles derniers, leur richesse économique relative s’inverser l’un par rapport à l’autre en fonction de leur degré d’intégration au commerce international et au capitalisme occidental. Depuis la seconde guerre mondiale, l’écart n’a cessé de se creuser en faveur de la Thaïlande, qui est en train de rejoindre les Nouveaux Pays Industriels. Une cartographie de synthèse montre l’alternance de la richesse économique et l’écart qui n’a cessé de se creuser. L’Asie du Sud-Est continentale naguère déchirée, écartelée par les dominations extérieures (impérialismes britannique et français, puis nippo-américain a tendance à se recomposer en un ensemble dominé par la Thaïlande qui s’affirme de plus en plus comme la puissance économique centrale de la péninsule indochinoise.

  3. Cultura Hospitalaria y el proceso narrativo en el niño enfermo

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    Verónica Miriam Guzmán Sandoval

    2011-01-01

    Full Text Available Las experiencias traumáticas que viven las niñas y los niños hospitalizados impactan su percepción de bienestar así como la manera en la que construyen su realidad durante el internamiento. Lo anterior se inscribe en la cultura hospitalaria, visión institucional que influye en la forma de percibir a los usuarios e interrelacionarse con ellos, de tal manera que el hospital se convierte en un transmisor de significados que fortalecen o debilitan el papel de los pacientes y sus familiares. La narración de los sucesos experimentados durante un internamiento médico conforma un proceso activo y cotidiano de reconstrucción de lo vivido. El objetivo de la investigación fue analizar el proceso narrativo de niñas y niños del servicio de infecto pediatría y ortopedia para conocer cómo perciben el hospital, así como analizar el impacto de la narrativa en la reestructuración y en la resignificación de la experiencia traumática. Metodología: se trabajó con cinco niños y niñas con edades entre 7 y 14 años, internados en el área de infectología pediátrica y ortopedia del hospital civil "Fray Antonio Alcalde" de Guadalajara, México. Las sesiones de trabajo fueron individuales y consecutivas, con una duración de una hora y media. Para la exploración se usaron dos guías de entrevista: la primera comprendió vida previa a la hospitalización y experiencia hospitalaria; la segunda exploró indicadores de ansiedad y estrategias de enfrentamiento al estrés. La narración de cada niño se analizó mediante la metodología de Bertaux. Resultados: la edad de los participantes, el tiempo de internamiento, las hospitalizaciones previas, la capacidad de afrontamiento y la duración del apoyo psicológico recibido, fueron los factores que impactaron en la percepción de la cultura hospitalaria. Se observó que el proceso narrativo permitió a los participantes salir de la trama saturada y mirar desde otra óptica las problemáticas, además de

  4. CART peptide and opioid addiction: Expression changes in male rat brain.

    Science.gov (United States)

    Bakhtazad, A; Vousooghi, N; Garmabi, B; Zarrindast, M R

    2016-06-14

    Previous studies have shown the prominence of cocaine- and amphetamine-regulated transcript (CART) peptide in rewarding and reinforcing effects of drugs of abuse specially psychostimulants. The data regarding the effects of different stages of opioid addiction on CART expression and the interconnection between CART and opioids are not much available. Here we have studied the changes in the expression level of CART mRNA and protein in various parts of the brain reward pathway in different stages of opioid addiction. Groups of male rats received acute low-dose (10mg/kg), acute high-dose (80mg/kg) and chronic escalating doses of morphine. In addition, withdrawal and abstinence states were evaluated after injection of naloxone (1mg/kg) and long-term maintenance of addicted animals, respectively. Expression of CART mRNA in the brain was measured by real-time PCR method. Western blotting was used to quantify the protein level. CART mRNA and protein were both up-regulated in high-dose morphine-administered animals and also in the withdrawal group in the nucleus accumbens (NAc), striatum and prefrontal cortex (PFC). In the addicted group, CART mRNA and protein were both down-regulated in NAc and striatum. In the abstinent group, CART mRNA was down-regulated in NAc. In the hippocampus, the only observed change was the up-regulation of CART mRNA in the withdrawal group. We suggest that the modulatory role of CART peptide in rewarding and reinforcing effects of opioids weakens when opioids are used for a long time and is stimulated when acute stress such as naloxone-induced withdrawal syndrome or acute high-dose administration of morphine occurs to the animal.

  5. Mortalidade materna na cidade do Recife Maternal mortality in Recife

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    Aurélio Antônio Ribeiro Costa

    2002-08-01

    Full Text Available Objetivos: determinar a Razão de Mortalidade Materna (RMM entre mulheres residentes na cidade do Recife, pela análise de todas as declarações de óbito de mulheres na idade entre 10-49 anos. Determinar a taxa de sub-registro e estudar as principais características, causas básicas, classificação e evitabilidade das mortes maternas. Métodos: realizou-se estudo descritivo de base populacional, analisando-se todos as declarações de óbito de mulheres entre 10-40 anos e utilizando-se os critérios de Laurenti para classificá-los como declarados ou presumíveis. Estudaram-se os prontuários médicos e os dados de autópsia, quando disponíveis, determinando-se as causas básicas dos óbitos e calculando-se a taxa de sub-registro. A Razão de Mortalidade Materna foi calculada usando as informações sobre nascidos vivos do SINASC (Sistema de Informações dos Nascidos Vivos. Resultados: encontraram-se 144 mortes maternas, sendo 104 declaradas e 44 presumíveis, confirmadas após investigação. A Razão de Mortalidade Materna foi 75,5 por 100.000 nascidos vivos e o percentual de sub-registro foi 27,8%. Observou-se uma predominância de causas diretas, sendo as mais freqüentes hipertensão (19%, hemorragia (16% e infecção (11%. Cerca de 82% das mortes foram consideradas evitáveis por meio de assistência adequada ao pré-natal, parto e puerpério. Conclusões: a Razão de Mortalidade Materna é alta na cidade de Recife, e o percentual de subnotificação permanece elevado. Predominam as causas diretas e os óbitos evitáveis, evidenciando ausência de assistência adequada ao pré-natal, parto e puerpério.Purpose: to determine the Maternal Mortality Ratio (MMR among women living in the city of Recife, Brazil through the analysis of all death certificates of women aged 10-49 years from 1994 to 2000. To determine the underreporting rate and to study the main characteristics, basic causes, classification and avoidance of maternal deaths

  6. Mortalidade infantil em município da região Centro-Oeste Paulista, Brasil, 1990 a 1992

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    Gomes Jaime de O.

    1997-01-01

    Full Text Available INTRODUÇÃO: A mortalidade infantil em Presidente Prudente, SP (Brasil, foi estudada no período de 1990 a 1992, a partir de aplicação de métodos para obtenção de diagnóstico coletivo que orientassem a identificação e escolha de estratégias de controle de problemas locais. MATERIAL E MÉTODO: Foram utilizadas declarações de óbito colhidas no cartório, cujos dados originais foram corrigidos por meio de pesquisa documental nos serviços de saúde e entrevistas domiciliares. Para estudar variáveis como idade materna e peso ao nascer foram utilizados os dados do Sistema de Informações sobre Nascidos Vivos (SINASC. A qualidade dos dados originais das declarações de óbitos foi inicialmente analisada pela quantidade de informações, sensibilidade, especificidade e valor de Kappa. RESULTADO: A sensibilidade global para a causa básica de óbito foi 78,84% e Kappa igual a 71,32 para o total de causas. Ocorreram 189 óbitos, sendo 66,15% no período neonatal (41,28% durante o primeiro dia de vida e 33,85% no infantil tardio. O peso ao nascer de 58,28% dos óbitos foi menor que 2.500g. As causas básicas de óbito foram estudadas segundo a possibilidade de serem prevenidas (método desenvolvido por Erica Taucher por grupos de causas reduzidas utilizadas no "International Collaborative Effort" (ICE, causas múltiplas e distribuição geográfica. Observou-se que nos óbitos ocorridos até 27 dias, 22,23% poderiam ser evitados por adequada atenção ao parto, 20,64% seriam redutíveis por diagnóstico e tratamento precoce, 13,75% por bom controle da gravidez e apenas 7,94% não evitáveis. Das mortes ocorridas no período infantil tardio, 12,17% foram classificadas como outras preveníveis e 4,23% foram consideradas não evitáveis. Segundo os grupos do ICE, 58,74% faleceram por imaturidade ou asfixias; 19,58% por infecções e, 12,17%, por anomalias congênitas. CONCLUSÃO: Os resultados sugerem prioridade para assistência obst

  7. Mortalidade perinatal e evitabilidade: revisão da literatura

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    Sônia Lansky

    2002-12-01

    Full Text Available Neste artigo, realizou-se uma revisão da literatura sobre mortalidade perinatal com maior enfoque na evitabilidade desses óbitos. Foram pesquisadas, sobretudo, publicações da década de 90 nas bases Medline e Lilacs (América Latina e Caribe. Discutiram-se as dificuldades para a realização de estudos nesta área, ainda em número restrito no Brasil, em decorrência do grande subregistro de óbitos fetais e da má qualidade da informação nas declarações de óbitos. Foram apresentadas as principais propostas de classificação dos óbitos perinatais baseadas em enfoque de evitabilidade, com destaque para a classificação de Wigglesworth. Nesta abordagem, os óbitos perinatais foram relacionados a momentos específicos da assistência, sendo evidenciadas as possibilidades de sua prevenção. Recomenda-se o enfoque de evitabilidade para a abordagem da mortalidade perinatal no Brasil, dado que as taxas são ainda elevadas, a maioria dos óbitos é considerada evitável e poderia ser prevenida com a melhoria da assistência pré-natal, ao parto e ao recém-nascido, não apenas quanto à sua resolubilidade clínica, mas também à organização da assistência em sistemas hierarquizados e regionalizados, assegurando o acesso da gestante e do recém-nascido em tempo oportuno a serviços de qualidade.

  8. El empoderamiento político de los enfermeros en la práctica hospitalaria

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    Adrize Rutz Porto

    2015-06-01

    Full Text Available Objetivo: comprender el proceso de búsqueda del empoderamiento político de las enfermeras en la práctica hospitalaria. Metodología: se trata de un estudio cualitativo, participaron 10 enfermeras de diferentes unidades de un hospital escuela en Rio Grande do Sul. Los datos fueron recolectados entre abril y julio de 2011, mediante observación simple, entrevistas semiestructuradas y grupo focal. El contenido obtenido fue tratado por el análisis temático, surgiendo dos temas sobre los obstáculos, bien como de las potencialidades de los enfermeros en su búsqueda del empoderamiento político. Resultados principales: se puede visualizar la correlación de fuerzas existentes en el hospital con respecto a el enfermero como un ser político. Conclusión: por un lado, existe la alienación, la propagación del conformismo, de los otros, medios posibles del poder en trabajar juntos, a través de posicionamiento con conocimiento y conciencia crítica sobre el proceso de trabajo y las relaciones interpersonales.

  9. Neurodesarrollo en egresados de la terapia intensiva neonatal a los 6 meses del alta hospitalaria

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    Dayami Armas-Guerra

    2012-01-01

    Full Text Available Se abordó estudio descriptivo longitudinal de 16 recién nacidos egresados del servicio de Neonatología del Hospital Pediátrico de Holguín, desde febrero a junio del 2009. Se les evaluó desde el punto de vista neurológico a los seis meses del alta hospitalaria. Un 25% presentaron anormalidad del examen neurológico. Las alteraciones leves y moderadas se comportaron igual. El sexo femenino fue el más afectado, la menor edad gestacional y el peso menor de 1500 gramos predispusieron a la aparición de secuelas. La ventilación mecánica, la encefalopatía hipóxico isquémica, intervenciones quirúrgicas complejas, el daño cerebral detectado por ultrasonografía transfontanelar, la edad gestacional por debajo de 34 semanas y la hipoglicemia están vinculados a la anormalidad neurológica de forma significativa.

  10. Immunohistochemical distribution of cocaine and amphetamine regulatory peptide-like immunoreactive (CART-LI) nerve fibers in the circular muscle layer and their relationship to other peptides in the human caecum.

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    Bulc, Michał; Gonkowski, Sławomir; Landowski, Piotr; Kamińska, Barbara; Całka, Jarosław

    2014-07-01

    Motor activity of the gastrointestinal tract is extensively controlled by the enteric nervous system (ENS). Numerous neurotransmitters and neuromodulators are responsible for this regulation. One of them is cocaine- and amphetamine-regulated transcript peptide (CART). So far, there are few reports available concerning the distribution, functions, and co-localization of CART in the human gastrointestinal tract. The aim of the present investigation was to study the distribution and degree of co-localization of CART with substances taking part in conducting sensory stimuli, such as: substance P (SP), neurokinin A (NKA), calcitonin gene related peptide (CGRP) and Leu 5 enkephalin (L-ENK) in the circular muscle layer of the human caecum. CART-like immunoreactive (CART-LI) nerve fibers formed a very dense meshwork in the circular muscle layer of the caecum in all patients studied. Moreover, all neuronal substances tested during the present investigation were observed in CART-LI processes, but the degree of co-localization depended on the type of substance. The highest number of CART-positive nerves also contained L-ENK. A slightly lower level of co-localization was observed in the case of CART and SP or NKA, while only single nerve fibers were simultaneously CART- and CGRP-positive.

  11. An ergonomic evaluation of handle height and load in maximal and submaximal cart pushing.

    Science.gov (United States)

    Resnick, M L; Chaffin, D B

    1995-06-01

    Awareness of the hazards of repetitive lifting has brought about significant changes in the design of industrial jobs. Pushing and pulling tasks have become increasingly common as the result of the introduction of a variety of carts and other materials-handling assistance devices. In order to predict the peak performance of workers in these tasks, and the biomechanical stresses that can result from them, the exertions involved in cart pushing were studied. Four subjects of various strengths pushed carts with loads from 45 to 450 kg at several heights. Peak push forces reached 500 N for male subjects and 200 N for female subjects. Strong subjects moved a 45 kg cart at velocities of 1.1 m s(-1) and a 450 kg cart at velocities of 0.8 m s(-1). Weaker subjects moved the carts at velocities of 0.5 and 0.4 m s(-1) respectively. Calculated static compression forces at the L5/S1 spinal disc were consistently above the NIOSH Action Limit of 3400 N for strong subjects when the cart load reached 225 kg.

  12. Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy.

    Science.gov (United States)

    Golubovskaya, Vita; Wu, Lijun

    2016-01-01

    This review is focused on different subsets of T cells: CD4 and CD8, memory and effector functions, and their role in CAR-T therapy--a cellular adoptive immunotherapy with T cells expressing chimeric antigen receptor. The CAR-T cells recognize tumor antigens and induce cytotoxic activities against tumor cells. Recently, differences in T cell functions and the role of memory and effector T cells were shown to be important in CAR-T cell immunotherapy. The CD4⁺ subsets (Th1, Th2, Th9, Th17, Th22, Treg, and Tfh) and CD8⁺ memory and effector subsets differ in extra-cellular (CD25, CD45RO, CD45RA, CCR-7, L-Selectin [CD62L], etc.); intracellular markers (FOXP3); epigenetic and genetic programs; and metabolic pathways (catabolic or anabolic); and these differences can be modulated to improve CAR-T therapy. In addition, CD4⁺ Treg cells suppress the efficacy of CAR-T cell therapy, and different approaches to overcome this suppression are discussed in this review. Thus, next-generation CAR-T immunotherapy can be improved, based on our knowledge of T cell subsets functions, differentiation, proliferation, and signaling pathways to generate more active CAR-T cells against tumors.

  13. Identification and differential distribution of CART in the small intestine depending on the diet.

    Science.gov (United States)

    Janiuk, I; Olkowski, B; Szczotka-Bochniarz, A

    2014-12-01

    This study was aimed at identifying and locating cocaine- and amphetamine-regulated transcript (CART) in the small intestine of broilers in relation to the diet. The feeding regime of the chicks was based on diets largely consisting of maize and one of four protein sources: post-extraction soya bean meal (SBM) or non-GM seed meal - meal from traditional variety of soy seeds Glicine max (FFS) and meal from seeds of Lupinus angustifolius (LA) and Lupinus luteus L (LY). The presence of cocaine- and amphetamine-regulated transcript immunoreactive (CART-IR) in the wall of the small intestine of the chicks was determined on the basis of staining patterns produced by the immunohistochemical method (IHC). CART-IR structures were found in the myenteric plexus (MP), submucosus plexus (SP), in endomucosal fibres, and fibres innervating miocytes and blood vessels in the muscularis membrane and adipocytes of the white adipose tissue (WAT) located on the perimeter of the serous membrane and single cells of the diffuse neuroendocrine system. Based on microscopic observation and result analysis, the lowest number of CART-IR structures was identified in the group that was fed the SBM-based diet. This study confirms previous observations concerning CART distribution in the gastrointestinal tract (GIT) of animal and broadens current knowledge by inclusion of chicken in the list of CART-positive species. Moreover, this work provides evidence that dietary composition can be a factor that stimulates post-prandial CART secretion in intestinal nerve structures.

  14. Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy

    Directory of Open Access Journals (Sweden)

    Vita Golubovskaya

    2016-03-01

    Full Text Available This review is focused on different subsets of T cells: CD4 and CD8, memory and effector functions, and their role in CAR-T therapy––a cellular adoptive immunotherapy with T cells expressing chimeric antigen receptor. The CAR-T cells recognize tumor antigens and induce cytotoxic activities against tumor cells. Recently, differences in T cell functions and the role of memory and effector T cells were shown to be important in CAR-T cell immunotherapy. The CD4+ subsets (Th1, Th2, Th9, Th17, Th22, Treg, and Tfh and CD8+ memory and effector subsets differ in extra-cellular (CD25, CD45RO, CD45RA, CCR-7, L-Selectin [CD62L], etc.; intracellular markers (FOXP3; epigenetic and genetic programs; and metabolic pathways (catabolic or anabolic; and these differences can be modulated to improve CAR-T therapy. In addition, CD4+ Treg cells suppress the efficacy of CAR-T cell therapy, and different approaches to overcome this suppression are discussed in this review. Thus, next-generation CAR-T immunotherapy can be improved, based on our knowledge of T cell subsets functions, differentiation, proliferation, and signaling pathways to generate more active CAR-T cells against tumors.

  15. Meta-CART: A tool to identify interactions between moderators in meta-analysis.

    Science.gov (United States)

    Li, Xinru; Dusseldorp, Elise; Meulman, Jacqueline J

    2017-02-01

    In the framework of meta-analysis, moderator analysis is usually performed only univariately. When several study characteristics are available that may account for treatment effect, standard meta-regression has difficulties in identifying interactions between them. To overcome this problem, meta-CART has been proposed: an approach that applies classification and regression trees (CART) to identify interactions, and then subgroup meta-analysis to test the significance of moderator effects. The previous version of meta-CART has its shortcomings: when applying CART, the sample sizes of studies are not taken into account, and the effect sizes are dichotomized around the median value. Therefore, this article proposes new meta-CART extensions, weighting study effect sizes by their accuracy, and using a regression tree to avoid dichotomization. In addition, new pruning rules are proposed. The performance of all versions of meta-CART was evaluated via a Monte Carlo simulation study. The simulation results revealed that meta-regression trees with random-effects weights and a 0.5-standard-error pruning rule perform best. The required sample size for meta-CART to achieve satisfactory performance depends on the number of study characteristics, the magnitude of the interactions, and the residual heterogeneity.

  16. 永不落空的"CART"法

    Institute of Scientific and Technical Information of China (English)

    薛福连

    2001-01-01

    @@ 在一本由罗伯特·哈夫所著的国外畅销书籍《如何在这个疯狂世界里找到一份好工作》中,提出了四种谋得理想工作的方法,的确为"四字真言".它们用英文表达的是"CART"即"Contacts(熟人门路);Advertisement(广告);Recruiter(招聘者);Temporary(临时职位).细细一想,简单的四个英文字母蕴含的却是求职的精华.毕竟,找工作有找工作的窍门,不掌握这些窍门理想的工作绝不会自己送上门来.

  17. CART III: improved camouflage assessment using moving target indication

    Science.gov (United States)

    Müller, Thomas; Honke, Thomas; Müller, Markus

    2009-05-01

    In order to facilitate systematic, computer aided improvements of camouflage and concealment assessment methods, the software system CART (Camouflage Assessment in Real-Time) was built up for the camouflage assessment of objects in image sequences (see contributions to SPIE 2007 and SPIE 2008 [1], [2]). It works with visual-optical, infrared and SAR image sequences. The system comprises a semi-automatic annotation functionality for marking target objects (ground truth generation) including a propagation of those markings over the image sequence for static as well as moving scene objects, where the recording camera may be static or moving. The marked image regions are evaluated by applying user-defined feature extractors, which can easily be defined and integrated into the system via a generic software interface. This article presents further systematic enhancements made in the recent year and addresses particularly the task of the detection of moving vehicles by latest image exploitation methods for objective camouflage assessment in these cases. As a main topic, the loop was closed between the two natural opposites of reconnaissance and camouflage, which was realized by incorporating ATD (Automatic Target Detection) algorithms into the computer aided camouflage assessment. Since object (and sensor) movement is an important feature for many applications, different image-based MTI (Moving Target Indication) algorithms were included in the CART system, which rely on changes in the image plane from an image to the successive one (after camera movements are automatically compensated). Additionally, the MTI outputs over time are combined in a certain way which we call "snail track" algorithm. The results show that their output provides a valuable measurement for the conspicuity of moving objects and therefore is an ideal component in the camouflage assessment. It is shown that image-based MTI improvements lead to improvements in the camouflage assessment process.

  18. Evaluation of density and distribution of CART-immunoreactive structures in gastrointestinal tract of hypertensive rats.

    Science.gov (United States)

    Kasacka, Irena; Piotrowska, Zaneta

    2012-01-01

    The prevalence of CART (cocaine- and amphetamine-regulated transcript) throughout the organism, multiplicity of functions fulfilled by that peptide, and the collected evidence confirming CART contribution to blood pressure regulation prompted us to undertake the research aiming to identify, localize, and assess changes in CART-immunopositive structures of the gastrointestinal tract (GI tract) of rats with renovascular hypertension. The two-kidney one-clip model of arterial hypertension was used to evaluate the location and density of CART-containing structures in the stomach (cardia, fundus, and pylorus), duodenum, jejunum, ileum, and colon of hypertensive rats. The study was carried out on the GI tract of 20 rats. Ten rats were subjected to the renal artery clipping procedure and after a 6-week period each of them developed stable hypertension. An immunohistochemical localization of CART was performed on paraffin GI tract sections from all the study animals. CART was detected in the extensive population of neurons, particularly within the myenteric plexuses all along the GI tract, and also in neuroendocrine cells, being especially numerous in the stomach and a few in the small intestine. The hypertension significantly increased the density of CART-positive structures in the rat GI tract. The differences between the hypertensive rats and the control animals concerned not only the density of CART-immunoreactive structures but also the staining intensity. As this study provides novel findings, we are planning further molecular examinations to better understand the impact of hypertension on the functioning and activity of CART in the GI tract.

  19. New analogs of the CART peptide with anorexigenic potency: the importance of individual disulfide bridges.

    Science.gov (United States)

    Blechová, Miroslava; Nagelová, Veronika; Záková, Lenka; Demianová, Zuzana; Zelezná, Blanka; Maletínská, Lenka

    2013-01-01

    The CART (cocaine- and amphetamine-regulated transcript) peptide is an anorexigenic neuropeptide that acts in the hypothalamus. The receptor and the mechanism of action of this peptide are still unknown. In our previous study, we showed that the CART peptide binds specifically to PC12 rat pheochromocytoma cells in both the native and differentiated into neuronal phenotype. Two biologically active forms, CART(55-102) and CART(61-102), with equal biological activity, contain three disulfide bridges. To clarify the importance of each of these disulfide bridges in maintaining the biological activity of CART(61-102), an Ala scan at particular S-S bridges forming cysteines was performed, and analogs with only one or two disulfide bridges were synthesized. In this study, a stabilized CART(61-102) analog with norleucine instead of methionine at position 67 was also prepared and was found to bind to PC12 cells with an anorexigenic potency similar to that of CART(61-102). The binding study revealed that out of all analogs tested, [Ala(68,86)]CART(61-102), which contains two disulfide bridges (positions 74-94 and 88-101), preserved a high affinity to both native PC12 cells and those that had been differentiated into neurons. In food intake and behavioral tests with mice after intracerebroventricular administration, this analog showed strong and long-lasting anorexigenic potency. Therefore, the disulfide bridge between cysteines 68 and 86 in CART(61-102) can be omitted without a loss of biological activity, but the preservation of two other disulfide bridges and the full-length peptide are essential for biological activity.

  20. Consumo de tabaco, mortalidad y política fiscal en México

    OpenAIRE

    José Alberto Muños-Hernández; Carlos Manuel Guerrero-López; Luz Myriam Reynales-Shigematsu; Belén Sáenz de Miera-Juárez

    2013-01-01

    Objetivo. Analizar el tabaquismo, su impacto en mortalidad por enfermedades crónicas y su política fiscal en México. Material y métodos. Se analizaron las encuestas nacionales de salud (ENSA, ENSANUT), registros de mortalidad y encuestas económicas para el periodo 2000-2012 y se estimaron prevalencia, mortalidad y consumo. Resultados. En 2012, 9.2% de los adolescentes y 19% de los adultos son fumadores activos. Entre 2000 y 2012 la prevalencia de tabaquismo permaneció estable. Sin embargo, la...

  1. Autopercepción de salud general y mortalidad en adultos mayores

    Directory of Open Access Journals (Sweden)

    Ximena Moreno

    2014-05-01

    Conclusiones: Los resultados apoyan los hallazgos previos respecto a que la autopercepción de la salud general negativa predice la mortalidad. Es necesario dilucidar los mecanismos por los que este indicador puede predecir la mortalidad en los adultos mayores, que pueden ser diferentes para hombres y mujeres. Se sugiere investigar el papel de la depresión, considerando que el efecto de la autopercepción de la salud sobre la mortalidad no estaba presente en los estudios que la incluían.

  2. Leucemia Infantojuvenil No Brasil: Um Estudo Sobre Tendências e Mortalidade

    OpenAIRE

    Silva, F.F.

    2014-01-01

    A leucemia é o tipo de neoplasia mais comum dos cânceres em crianças. Apesar das inúmeras lacunas, tais como grande número de causas mal definidas apresentadas pelo Sistema de Informação Sobre Mortalidade (SIM), ele ainda é a principal fonte de dados para pesquisas epidemiológicas. O objetivo foi estudar a variação de mortalidade por leucemias em crianças e adolescentes e relacioná-las à mortalidade por causas mal definidas bem como a tendência dos óbitos por leucemia no Espírito Santo. Foram...

  3. Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension

    Directory of Open Access Journals (Sweden)

    I. Janiuk

    2015-04-01

    Full Text Available Recent biological advances make it possible to discover new peptides associated with hypertension. The cocaine- and amphetamine-regulated transcript (CART is a known factor in appetite and feeding behaviour. Various lines of evidence suggest that this peptide participates not only in control of feeding behaviour but also in the regulation of the cardiovascular and sympathetic systems and blood pressure. The role of CART in blood pressure regulation led us to undertake a study aimed at analysing quantitative changes in CART-containing cells in urinary bladders (UB of rats with renovascular hypertension. We used the Goldblatt model of arterial hypertension (two-kidney, one clip to evaluate quantitative changes. This model provides researchers with a commonly used tool to analyse the renin-angiotensin system of blood pressure control and, eventually, to develop drugs for the treatment of chronic hypertension. The study was performed on sections of urinary bladders of rats after 3-, 14-, 28-, 42 and 91 days from hypertension induction. Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals. CART was detected in the endocrine cells, especially numerous in the submucosa and muscularis layers, with a few found in the transitional epithelium and only occasionally in serosa. Hypertension significantly increased the number of CART-positive cells in the rat UBs. After 3 and 42 days following the procedure, statistically significantly higher numbers of CART-positive cells were identified in comparison with the control animals. The differences between the hypertensive rats and the control animals concerned not only the number density of CART-immunoreactive cells but also their localization. After a 6-week period, each of the rats subjected to the renal artery clipping procedure developed stable hypertension. CART appeared in numerous transitional epithelium cells. As this study provides novel findings

  4. Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension.

    Science.gov (United States)

    Janiuk, I; Kasacka, I

    2015-04-13

    Recent biological advances make it possible to discover new peptides associated with hypertension. The cocaine- and amphetamine-regulated transcript (CART) is a known factor in appetite and feeding behaviour. Various lines of evidence suggest that this peptide participates not only in control of feeding behaviour but also in the regulation of the cardiovascular and sympathetic systems and blood pressure. The role of CART in blood pressure regulation led us to undertake a study aimed at analysing quantitative changes in CART-containing cells in urinary bladders (UB) of rats with renovascular hypertension. We used the Goldblatt model of arterial hypertension (two-kidney, one clip) to evaluate quantitative changes. This model provides researchers with a commonly used tool to analyse the renin-angiotensin system of blood pressure control and, eventually, to develop drugs for the treatment of chronic hypertension. The study was performed on sections of urinary bladders of rats after 3-, 14-, 28-, 42 and 91 days from hypertension induction. Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals. CART was detected in the endocrine cells, especially numerous in the submucosa and muscularis layers, with a few found in the transitional epithelium and only occasionally in serosa. Hypertension significantly increased the number of CART-positive cells in the rat UBs. After 3 and 42 days following the procedure, statistically significantly higher numbers of CART-positive cells were identified in comparison with the control animals. The differences between the hypertensive rats and the control animals concerned not only the number density of CART-immunoreactive cells but also their localization. After a 6-week period, each of the rats subjected to the renal artery clipping procedure developed stable hypertension. CART appeared in numerous transitional epithelium cells. As this study provides novel findings, the question

  5. Discontinuation of cART postpartum in a high prevalence district of South Africa in 2014

    OpenAIRE

    2014-01-01

    Background Combination antiretroviral therapy (cART) is the current strategy to prevent mother-to-child transmission (PMTCT) of HIV. Women initiated on cART should continue taking treatment life-long or stop after cessation of breastfeeding depending on their CD4 cell count or on their World Health Organization (WHO) staging. Keeping people living with HIV on treatment is essential for the success of any antiretroviral therapy (ART) programme. There has been a rapid scale-up of cART in the PM...

  6. Quantitative Evaluation of CART-Containing Cells in Urinary Bladder of Rats with Renovascular Hypertension

    Science.gov (United States)

    Janiuk, I.; Kasacka, I.

    2015-01-01

    Recent biological advances make it possible to discover new peptides associated with hypertension. The cocaine- and amphetamine-regulated transcript (CART) is a known factor in appetite and feeding behaviour. Various lines of evidence suggest that this peptide participates not only in control of feeding behaviour but also in the regulation of the cardiovascular and sympathetic systems and blood pressure. The role of CART in blood pressure regulation led us to undertake a study aimed at analysing quantitative changes in CART-containing cells in urinary bladders (UB) of rats with renovascular hypertension. We used the Goldblatt model of arterial hypertension (two-kidney, one clip) to evaluate quantitative changes. This model provides researchers with a commonly used tool to analyse the renin-angiotensin system of blood pressure control and, eventually, to develop drugs for the treatment of chronic hypertension. The study was performed on sections of urinary bladders of rats after 3-, 14-, 28-, 42 and 91 days from hypertension induction. Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals. CART was detected in the endocrine cells, especially numerous in the submucosa and muscularis layers, with a few found in the transitional epithelium and only occasionally in serosa. Hypertension significantly increased the number of CART-positive cells in the rat UBs. After 3 and 42 days following the procedure, statistically significantly higher numbers of CART-positive cells were identified in comparison with the control animals. The differences between the hypertensive rats and the control animals concerned not only the number density of CART-immunoreactive cells but also their localization. After a 6-week period, each of the rats subjected to the renal artery clipping procedure developed stable hypertension. CART appeared in numerous transitional epithelium cells. As this study provides novel findings, the question

  7. Mortalidad atribuible al consumo de tabaco en México

    Directory of Open Access Journals (Sweden)

    Kuri-Morales Pablo

    2002-01-01

    Full Text Available Objetivo. Estudiar la asociación entre defunciones registradas en la delegación Coyoacán y consumo de tabaco y alcohol. Material y métodos. Estudio de mortalidad proporcional y determinación de fracción atribuible en una cohorte de sujetos de la ciudad de México, D.F., México. Se reunió información de todas las defunciones de 1998 captadas a través del Sistema Estadístico y Epidemiológico de las Defunciones (SEED en la delegación Coyoacán, clasificándolas por diagnóstico en enfermedades del sistema circulatorio (ESC, sistema respiratorio (EPOC, neoplasias (NEO. Se encuestó a familiares de los fallecidos sobre consumo de tabaco y alcohol. Resultados. Fumar los últimos 10 años de vida fue significativo para ESC en hombres de 70 años y más (RM: 2.06, IC 95%=1.18-3.58; y continuar fumando el último año de vida fue significativo para NEO y para EPOC en mujeres de 70 años y más (NEO= RM: 7.24, IC 95%=1.71-30.53; ESR= RM: 4.82, IC 95%=1.41-16.50. En el modelo de regresión para ESC, las personas con tabaquismo intenso tuvieron una posibilidad 0.83 veces mayor de fallecer por ESC, y el RA de esta variable para las ESC en la población general fue 45%. (RM=1.83; IC 95% = 1.1-2.8 p<0.01. Conclusiones. La exposición a tabaco es responsible de la elevada incidencia y mortalidad de enfermedades del sistema circulatorio y respiratorio, así como de neoplasias, en una muestra poblacional de sujetos de la ciudad de México.

  8. Management of animal energy resources and the modernization of the bullock-cart system

    Energy Technology Data Exchange (ETDEWEB)

    Ramaswamy, N.S.

    1979-01-01

    The significance of animal energy, especially in the transportation sector to the economies of India, China, Indonesia and other countries and the redesign of bullock-carts for more efficient use of animal energy are discussed. (LCL)

  9. Shopper marketing nutrition interventions: Social norms on grocery carts increase produce spending without increasing shopper budgets

    Directory of Open Access Journals (Sweden)

    Collin R. Payne

    2015-01-01

    Conclusions: Descriptive and provincial social norm messages (i.e., on grocery cart placards may be an overlooked tool to increase produce demand without decreasing store profitability and increasing shopper budgets.

  10. The Communities Advancing Resilience Toolkit (CART): an intervention to build community resilience to disasters.

    Science.gov (United States)

    Pfefferbaum, Rose L; Pfefferbaum, Betty; Van Horn, Richard L; Klomp, Richard W; Norris, Fran H; Reissman, Dori B

    2013-01-01

    Community resilience has emerged as a construct to support and foster healthy individual, family, and community adaptation to mass casualty incidents. The Communities Advancing Resilience Toolkit (CART) is a publicly available theory-based and evidence-informed community intervention designed to enhance community resilience by bringing stakeholders together to address community issues in a process that includes assessment, feedback, planning, and action. Tools include a field-tested community resilience survey and other assessment and analytical instruments. The CART process encourages public engagement in problem solving and the development and use of local assets to address community needs. CART recognizes 4 interrelated domains that contribute to community resilience: connection and caring, resources, transformative potential, and disaster management. The primary value of CART is its contribution to community participation, communication, self-awareness, cooperation, and critical reflection and its ability to stimulate analysis, collaboration, skill building, resource sharing, and purposeful action.

  11. Mathematical modelling of translational motion of rail-guided cart with suspended payload

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper modelling of the translational motion of transportation rail-guided cart with rope suspended payload is considered. The linearly moving cart, driven by a travel mechanism, is modelled as a discrete six degrees of freedom (DOF) dynamic system. The hoisting mechanism for lowering and lifting the payload is considered and is included in the dynamic model as one DOF system. Differential equations of motion of the cart elements are derived using Lagrangian dynamics and are solved for a set of real-life constant parameters of the cart. A two-sided interaction was observed between the swinging payload and the travel mechanism. Results for kinematical and force parameters of the system are obtained. A verification of the proposed model was conducted.

  12. Pro-cognitive action of CART is mediated via ERK in the hippocampus.

    Science.gov (United States)

    Bharne, Ashish P; Borkar, Chandrashekhar D; Bodakuntla, Satish; Lahiri, Mayurika; Subhedar, Nishikant K; Kokare, Dadasaheb M

    2016-10-01

    Although cocaine- and amphetamine-regulated transcript peptide (CART) is detected in several cortical and subcortical areas, its role in higher functions has been largely ignored. We examined the significance of CART in memory formation and tested if the downstream actions of CART involve N-methyl-d-aspartate (NMDA) activated extra-cellular signal-regulated kinase (ERK). Newly formed memory was evaluated using novel object recognition test consisting of familiarization (T1) and choice trials (T2). The choice trials were performed at two time points: 30-min (T230-min ) and 24-h (T224-h ) postacquisition. In choice trial (T230-min ), vehicle control rats explored the novel object for significantly longer duration than the familiar object indicating intact memory formation. However, CART-antibody, U0126 [ERK antagonist, both via intracerebroventricular (icv) or intrahippocampal (ih) route] or MK-801 (NMDA antagonist; intraperitoneal) treated rats spent less time exploring novel objects; CART peptide (icv or ih) was ineffective. During choice trial at T224-h , a significant decrease in novel object exploration time was noticed in vehicle control rats suggesting amnesia. However, treatment with CART, prior to familiarization trial (T1), promoted exploration of the novel object even at T224-h . Pretreatment with U0126 or MK-801 blocked pro-cognitive-like effect of CART suggesting involvement of NMDA-ERK pathway in CART's action. Animals subjected to the object familiarization trial showed a drastic increase in the CART-immunoreactivity in the cells of cornu ammonis 3 and polymorph layer of dentate gyrus, and fibers within ento- (ENT) and peri-rhinal (PRH) cortices. Western blot analysis revealed that CART treatment significantly up-regulated the expression of phospo-ERK1/2 in hippocampus, ENT and PRH. This effect was attenuated following pretreatment with U0126 or MK-801, suggesting the activation of ERK signaling cascade through NMDA receptors. Thus, CART system seems

  13. Triage en urgencias y emergencias hospitalarias: revisión de los principales sistemas de triage internacionales.

    OpenAIRE

    Estebaranz Santamaría, Cristina

    2014-01-01

    Trabajo fin de grado en Enfermería Introducción. El “triage” es un proceso de valoración que permite priorizar el nivel de urgencia de los pacientes. Para su aplicación, se utilizan los sistemas de triage estructurado, existiendo en la actualidad cinco modelos a nivel internacional. Objetivo. Analizar los sistemas de triage en el servicio de urgencias y emergencias hospitalarias, determinando las diferencias de sus últimas actualizaciones. Material y método. Revisión narrati...

  14. Diagnósticos al alta hospitalaria de las personas inmigrantes en la ciudad de Valencia (2001-2002)

    OpenAIRE

    Antonio Salazar; Elena Navarro-Calderón; Irene Abad; Vicent Alberola; Fernando Almela; Rafael Borrás; Antonio González; Emilio Gosálbez; Ma. José Moya; Pilar Palau; Fco Javier Roig; Ramón Romero; Francisco Taberner; Pilar Vicente

    2003-01-01

    Fundamento:La inmigración en España se ha incrementado de forma notable en la última década. Por razones teóricas se ha planteado que esta población pudiera ser responsable de un aumento de la incidencia y/o transmisión de enfermedades infecciosas. Sin embargo, existen escasos estudios acerca de las enfermedades de este colectivo que permitan conocer la importancia de esta afirmación. El objetivo de este estudio es cuantificar la atención hospitalaria a esta población en la ciudad de Valencia...

  15. Diagnósticos al alta hospitalaria de las personas inmigrantes en la ciudad de Valencia (2001-2002)

    OpenAIRE

    Salazar Antonio; Navarro-Calderón Elena; Abad Irene; Alberola Vicent; Almela Fernando; Borrás Rafael; González Antonio; Gosálbez Emilio; Moya Mª José; Palau Pilar; Roig Fco Javier; Romero Ramón; Taberner Francisco; Vicente Pilar

    2003-01-01

    Fundamento: La inmigración en España se ha incrementado de forma notable en la última década. Por razones teóricas se ha planteado que esta población pudiera ser responsable de un aumento de la incidencia y/o transmisión de enfermedades infecciosas. Sin embargo, existen escasos estudios acerca de las enfermedades de este colectivo que permitan conocer la importancia de esta afirmación. El objetivo de este estudio es cuantificar la atención hospitalaria a esta población en la ciudad de Valenci...

  16. La arquitectura hospitalaria y su evolución programática. Lima y Callao, 1955-2005

    OpenAIRE

    Villavisencio Ordóñez, Jorge Mauro Augusto

    2013-01-01

    La Tesis tiene como objetivo contar con los acercamientos históricos en la evolución de los programas arquitectónicos de los hospitales de Lima y Callao, en el periodo de 1955 a 2005. Se da inicio la investigación científica a partir de la historia de la arquitectura hospitalaria. Presentamos de forma objetiva como se realiza la programación de hospitales, en las unidades de los espacios y de sus relaciones interfuncionales del hospital. La importancia de saber cual es el significado del e...

  17. Expression of Cocaine and Amphetamine Regulated Transcript (CART) in the Porcine Intramural Neurons of Stomach in the Course of Experimentally Induced Diabetes Mellitus.

    Science.gov (United States)

    Bulc, Michał; Gonkowski, Sławomir; Całka, Jarosław

    2015-11-01

    In the present study, the effect of streptozotocin-induced diabetes on the cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) enteric nervous structures was investigated within the porcine stomach. To induce diabetes, the pigs were administered intravenously streptozotocin at a dose of 150 mg/kg of body weight. A significant decrease of the number of CART-LI perikarya was observed in the myenteric plexus of the gastric antrum, corpus, and pylorus in the experimental group. In contrast, submucous plexus was devoid of CART-positive neuronal cells both in control and experimental animals. In the control group, the highest densities of CART-LI nerve fibers were observed in the circular muscle layer of antrum and slightly less nerve fibers were present in the muscle layer of corpus and pylorus. In turn, submucous layer of all studied stomach regions revealed relatively smaller number of CART-positive nerve fibers. Diabetes caused statistically significant decrease in the expression of CART-LI nerve fibers only in the antrum circular muscle layer. Also, no changes in the CART-like immunoreactivity in the intraganglionic nerve fibers were observed. The obtained results suggest that acute hyperglycemia produced significant reduction of the CART expression in enteric perikarya throughout entire stomach as well as decrease of density the CART-LI fibers in circular muscle layer of the antrum. Additionally, we suggest that CART might be involved in the regulation of stomach function especially in the gastric motility.

  18. Peripherally injected CCK-8S activates CART positive neurons of the paraventricular nucleus in rats

    Science.gov (United States)

    Noetzel, Steffen; Inhoff, Tobias; Goebel, Miriam; Taché, Yvette; Veh, Rüdiger W.; Bannert, Norbert; Grötzinger, Carsten; Wiedenmann, Bertram; Klapp, Burghard F.; Mönnikes, Hubert; Kobelt, Peter

    2014-01-01

    Cholecystokinin (CCK) plays a role in the short-term inhibition of food intake. Cocaine- and amphetamine-regulated transcript (CART) peptide has been observed in neurons of the paraventricular nucleus (PVN). It has been reported that intracerebroventricular injection of CART peptide inhibits food intake in rodents. The aim of the study was to determine whether intraperitoneally (ip) injected CCK-8S affects neuronal activity of PVN-CART neurons. Ad libitum fed male Sprague-Dawley rats received 6 or 10 μg/kg CCK-8S or 0.15 M NaCl ip (n = 4/group). The number of c-Fos-immunoreactive neurons was determined in the PVN, arcuate nucleus (ARC), and the nucleus of the solitary tract (NTS). CCK-8S dose-dependently increased the number of c-Fos-immunoreactive neurons in the PVN (mean ± SEM: 102 ± 6 vs. 150 ± 5 neurons/section, p < 0.05) and compared to vehicle treated rats (18 ± 7, p < 0.05 vs. 6 and 10 μg/kg CCK-8S). CCK-8S at both doses induced an increase in the number of c-Fos-immunoreactive neurons in the NTS (65 ± 13, p < 0.05, and 182 ± 16, p < 0.05). No effect on the number of c-Fos neurons was observed in the ARC. Immunostaining for CART and c-Fos revealed a dose-dependent increase of activated CART neurons (19 ± 3 vs. 29 ± 7; p < 0.05), only few activated CART neuron were observed in the vehicle group (1 ± 0). The present observation shows that CCK-8S injected ip induces an increase in neuronal activity in PVN-CART neurons and suggests that CART neurons in the PVN may play a role in the mediation of peripheral CCK-8S's anorexigenic effects. PMID:20307613

  19. New developments of the CARTE thermochemical code: I-parameter optimization

    Science.gov (United States)

    Desbiens, N.; Dubois, V.

    We present the calibration of the CARTE thermochemical code that allows to compute the properties of a wide variety of CHON explosives. We have developed an optimization procedure to obtain an accurate multicomponents EOS (fluid phase and condensed phase of carbon). We show here that the results of CARTE code are in good agreement with the specific data of molecular systems and we extensively compare our calculations with measured detonation properties for several explosives.

  20. New developments of the CARTE thermochemical code: I-parameter optimization

    Directory of Open Access Journals (Sweden)

    Dubois V.

    2011-01-01

    Full Text Available We present the calibration of the CARTE thermochemical code that allows to compute the properties of a wide variety of CHON explosives. We have developed an optimization procedure to obtain an accurate multicomponents EOS (fluid phase and condensed phase of carbon. We show here that the results of CARTE code are in good agreement with the specific data of molecular systems and we extensively compare our calculations with measured detonation properties for several explosives.

  1. Reciprocal connections between CART-immunoreactive, hypothalamic paraventricular neurons and serotonergic dorsal raphe cells in the rat: Light microscopic study.

    Science.gov (United States)

    Lee, Ji S; Lee, Hyun S

    2014-04-29

    Based on the overlapping physiological roles of cocaine- and amphetamine-regulated transcript (CART) peptides and serotonin, the present study examined the anatomical connection between the hypothalamic paraventricular nucleus (PVN) and the dorsal raphe (DR). The first series of experiments were performed to investigate descending projections from the CART-immunoreactive (CART-ir) PVN to serotonergic DR cells. CART-ir varicosities made contact with serotonergic DR neurons. An anterograde tracing study revealed that varicosities originating from the PVN formed close appositions to serotonergic neuronal profiles along the entire rostro-caudal extent of the DR. A retrograde study demonstrated that CART neurons projecting to the DR were mainly localized in the caudal parvicellular PVN, comprising approximately 3.0%±0.4% (n=8) of total CART cells. A second series of experiments was performed to investigate ascending projections from the DR to CART-ir PVN cells. Serotonin transporter-ir boutons made contact with CART-ir PVN neurons. Anterograde tracing revealed that varicosities originating from the DR formed close appositions to CART-ir PVN cells. Retrograde examination demonstrated that serotonergic neurons projecting to the parvicellular PVN were located along the entire rostro-caudal extent of the DR. The present observation provided an anatomical basis for accumulating evidence in the literature that suggests a functional interaction between the CART and serotonin systems during the regulation of energy balance, emotional behavior, and arousal.

  2. Differential distribution and energy status-dependent regulation of the four CART neuropeptide genes in the zebrafish brain.

    Science.gov (United States)

    Akash, G; Kaniganti, Tarun; Tiwari, Neeraj Kumar; Subhedar, Nishikant K; Ghose, Aurnab

    2014-07-01

    The cocaine- and amphetamine-regulated transcript (CART) neuropeptide has been implicated in the neural regulation of energy homeostasis across vertebrate phyla. By using gene-specific in situ hybridization, we have mapped the distribution of the four CART mRNAs in the central nervous system of the adult zebrafish. The widespread neuronal expression pattern for CART 2 and 4 suggests a prominent role for the peptide in processing sensory information from diverse modalities including olfactory and visual inputs. In contrast, CART 1 and 3 have a much more restricted distribution, predominantly located in the nucleus of the medial longitudinal fasciculus (NMLF) and entopeduncular nucleus (EN), respectively. Enrichment of CART 2 and 4 in the preoptic and tuberal areas emphasizes the importance of CART in neuroendocrine functions. Starvation resulted in a significant decrease in CART-positive cells in the nucleus recessus lateralis (NRL) and nucleus lateralis tuberis (NLT) hypothalamic regions, suggesting a function in energy homeostasis for these neurons. Similarly, the EN emerges as a novel energy status-responsive region. Not only is there abundant and overlapping expression of CART 2, 3, and 4 in the EN, but also starvation induced a decrease in CART-expressing neurons in this region. The cellular resolution mapping of CART mRNA and the response of CART-expressing nuclei to starvation underscores the importance of CART neuropeptide in energy processing. Additionally, the regional and gene-specific responses to energy levels suggest a complex, interactive network whereby the four CART gene products may have nonredundant functions in energy homeostasis.

  3. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors.

    Science.gov (United States)

    Xu, Ying; An, Futing; Borycz, Jolanta A; Borycz, Janusz; Meinertzhagen, Ian A; Wang, Tao

    2015-12-01

    Histamine is an important chemical messenger that regulates multiple physiological processes in both vertebrate and invertebrate animals. Even so, how glial cells and neurons recycle histamine remains to be elucidated. Drosophila photoreceptor neurons use histamine as a neurotransmitter, and the released histamine is recycled through neighboring glia, where it is conjugated to β-alanine to form carcinine. However, how carcinine is then returned to the photoreceptor remains unclear. In an mRNA-seq screen for photoreceptor cell-enriched transporters, we identified CG9317, an SLC22 transporter family protein, and named it CarT (Carcinine Transporter). S2 cells that express CarT are able to take up carcinine in vitro. In the compound eye, CarT is exclusively localized to photoreceptor terminals. Null mutations of cart alter the content of histamine and its metabolites. Moreover, null cart mutants are defective in photoreceptor synaptic transmission and lack phototaxis. These findings reveal that CarT is required for histamine recycling at histaminergic photoreceptors and provide evidence for a CarT-dependent neurotransmitter trafficking pathway between glial cells and photoreceptor terminals.

  4. Robust Control Algorithm for a Two Cart System and an Inverted Pendulum

    Science.gov (United States)

    Wilson, Chris L.; Capo-Lugo, Pedro

    2011-01-01

    The Rectilinear Control System can be used to simulate a launch vehicle during liftoff. Several control schemes have been developed that can control different dynamic models of the rectilinear plant. A robust control algorithm was developed that can control a pendulum to maintain an inverted position. A fluid slosh tank will be attached to the pendulum in order to test robustness in the presence of unknown slosh characteristics. The rectilinear plant consists of a DC motor and three carts mounted in series. Each cart s weight can be adjusted with brass masses and the carts can be coupled with springs. The pendulum is mounted on the first cart and an adjustable air damper can be attached to the third cart if desired. Each cart and the pendulum have a quadrature encoder to determine position. Full state feedback was implemented in order to develop the control algorithm along with a state estimator to determine the velocity states of the system. A MATLAB program was used to convert the state space matrices from continuous time to discrete time. This program also used a desired phase margin and damping ratio to determine the feedback gain matrix that would be used in the LabVIEW program. This experiment will allow engineers to gain a better understanding of liquid propellant slosh dynamics, therefore enabling them to develop more robust control algorithms for launch vehicle systems

  5. Advancing monthly streamflow prediction accuracy of CART models using ensemble learning paradigms

    Science.gov (United States)

    Erdal, Halil Ibrahim; Karakurt, Onur

    2013-01-01

    SummaryStreamflow forecasting is one of the most important steps in the water resources planning and management. Ensemble techniques such as bagging, boosting and stacking have gained popularity in hydrological forecasting in the recent years. The study investigates the potential usage of two ensemble learning paradigms (i.e., bagging; stochastic gradient boosting) in building classification and regression trees (CARTs) ensembles to advance the streamflow prediction accuracy. The study, initially, investigates the use of classification and regression trees for monthly streamflow forecasting and employs a support vector regression (SVR) model as the benchmark model. The analytic results indicate that CART outperforms SVR in both training and testing phases. Although the obtained results of CART model in training phase are considerable, it is not in testing phase. Thus, to optimize the prediction accuracy of CART for monthly streamflow forecasting, we incorporate bagging and stochastic gradient boosting which are rooted in same philosophy, advancing the prediction accuracy of weak learners. Comparing with the results of bagged regression trees (BRTs) and stochastic gradient boosted regression trees (GBRTs) models possess satisfactory monthly streamflow forecasting performance than CART and SVR models. Overall, it is found that ensemble learning paradigms can remarkably advance the prediction accuracy of CART models in monthly streamflow forecasting.

  6. Early regulation of hypothalamic arcuate nucleus CART gene expression by short photoperiod in the Siberian hamster.

    Science.gov (United States)

    Mercer, Julian G; Ellis, Claire; Moar, Kim M; Logie, Tracy J; Morgan, Peter J; Adam, Clare L

    2003-03-28

    Cocaine- and amphetamine-regulated transcript (CART) mRNA is expressed in a number of hypothalamic nuclei including the arcuate nucleus (ARC). An increase in CART gene expression in the ARC of juvenile female Siberian hamsters (Phodopus sungorus) 14 days after transfer to short photoperiod at weaning and prior to major divergence of body weight trajectory in this seasonal mammal implicates CART in the induction of programmed weight change. In the current series of experiments, elevated CART mRNA in short photoperiod juvenile female animals relative to long photoperiod controls was apparent throughout the caudal-rostral extent of the ARC after 14 days, but was not observed when short photoperiod exposure was limited to 4-7 days. Elevated CART gene expression was also observed in juvenile males 14 days after transfer to short photoperiod at weaning, in adult female hamsters 14 days after transfer to short photoperiod and in adult male hamsters 21 days after transfer to short photoperiod. There were no consistent trends in expression levels of other energy balance-related genes with these relatively short duration photoperiod manipulations, suggesting that CART may be involved in short photoperiod-programmed body weight regulation.

  7. Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population

    Directory of Open Access Journals (Sweden)

    Hercberg Serge

    2005-04-01

    Full Text Available Abstract Background Cocaine and amphetamine regulated transcript (CART is an anorectic neuropeptide located principally in hypothalamus. CART has been shown to be involved in control of feeding behavior, but a direct relationship with obesity has not been established. The aim of this study was to evaluate the effect of polymorphisms within the CART gene with regards to a possible association with obesity in a Caucasian population. Results Screening of the entire gene as well as a 3.7 kb region of 5' upstream sequence revealed 31 SNPs and 3 rare variants ; 14 of which were subsequently genotyped in 292 French morbidly obese subjects and 368 controls. Haplotype analysis suggested an association with obesity which was found to be mainly due to SNP-3608T>C (rs7379701 (p = 0.009. Genotyping additional cases and controls also of European Caucasian origin supported further this possible association between the CART SNP -3608T>C T allele and obesity (global p-value = 0.0005. Functional studies also suggested that the SNP -3608T>C could modulate nuclear protein binding. Conclusion CART SNP -3608T>C may possibly contribute to the genetic risk for obesity in the Caucasian population. However confirmation of the importance of the role of the CART gene in energy homeostasis and obesity will require investigation and replication in further populations.

  8. Evaluación del estado actual de desarrollo del sistema de logística en tres entidades hospitalarias de Bogotá

    OpenAIRE

    2012-01-01

    Los problemas que se presentan en la logística empresarial o industrial pueden ser analizados desde la óptica de logística hospitalaria, ya que el objetivo final que se pretende conseguir es la optimización de los recursos. El tener un sistema de logística hospitalaria adecuado que tendrá un alto impacto en la eficiencia y eficacia de las operaciones, especialmente en el ahorro de costos, mejor uso de los recursos y aumento en la calidad de los servicios ofrecidos a los pacientes. El propósit...

  9. Factors Related to In-Hospital Mortality Caused by Acute Myocardial Infarction Factores relacionados con la mortalidad intrahospitalaria en el infarto agudo del miocardio

    Directory of Open Access Journals (Sweden)

    Francisco Valladares Carvajal

    2012-11-01

    Cienfuegos durante el año 2010. Método: se realizó un estudio de serie de casos, que incluyó 241 pacientes con diagnóstico de infarto agudo del miocardio, ingresados en la Unidad de Cuidados Intensivos Coronarios del Hospital General Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos, en el año 2010. Las variables que se analizaron fueron: edad, sexo, antecedentes patológicos personales, tipo de infarto agudo del miocardio (según electrocardiograma y localización topográfica, frecuencia cardiaca y tensión arterial al ingreso, clasificación de la insuficiencia cardiaca según Killip Kimball, creatinina, glicemia, colesterol total, triglicéridos, CPK-MB, y eventos adversos cardiovasculares durante su estadía hospitalaria. Resultados: la edad media de los pacientes estudiados fue de 65,6 años, con predominio del sexo masculino. La hipertensión arterial, el tabaquismo y el infarto miocárdico previo fueron los antecedentes de mayor interés, predominan los pacientes sin insuficiencia cardiaca y fracción de eyección conservada. Los eventos adversos cardiovasculares más frecuentes fueron: la angina post-infarto, arritmias ventriculares malignas y el choque cardiogénico. Conclusiones: se encontró relación significativa con la mortalidad para la edad avanzada (>70 años, taquicardia, glicemia ≥7 mmol/l al ingreso, y la presentación de arritmias ventriculares y choque cardiogénico durante la evolución intrahospitalaria.

  10. Mortalidade infantil em duas coortes de base populacional no Sul do Brasil: tendências e diferenciais Infant mortality in two population-based cohorts in southern Brazil: trends and differentials

    Directory of Open Access Journals (Sweden)

    Ana M. B. Menezes

    1996-01-01

    Full Text Available Estudou-se a tendência temporal da mortalidade infantil através de dois estudos de coorte realizados em Pelotas, Rio Grande do Sul, em 1982 e 1993. Ambas coortes incluíram todos os nascimentos hospitalares e óbitos verificados através de visitas regulares aos hospitais, cartórios e cemitérios. As informações sobre a causa de morte foram obtidas através de entrevistas com pediatras, revisão do prontuário, necrópsias e entrevista com os pais das crianças. O coeficiente de mortalidade infantil caiu de 36,4 por mil nascidos vivos para 21,1 na década. As principais causas de mortalidade infantil em 1993 foram as perinatais, malformações congênitas, diarréia e infecções respiratórias. Crianças com baixo peso ao nascer apresentaram mortalidade 12 vezes maior do que crianças com peso adequado, e crianças pré-termo, duas vezes mais do que crianças com retardo de crescimento intra-uterino. Crianças de famílias com renda baixa (um salário mínimo apresentaram mortalidade sete vezes superior àquelas com renda alta (10 salários mínimos. A mortalidade de crianças de baixo peso ao nascer e alta renda familiar decresceu em 67%, contra apenas 36% para as de baixa renda. Conclui-se que, mesmo com uma queda expressiva da mortalidade infantil na década, persistem importantes desigualdades sociais.Time trends in infant mortality were assessed through two cohort studies carried out in Pelotas, Southern Brazil, in 1982 and 1993. Both cohorts included all hospital deliveries, and deaths were monitored through regular visits to hospitals, cemeteries, and notary publics. Information on cause of death was obtained from pediatricians, case notes, autopsies, and home visits to parents. The infant mortality rate fell from 36.4 in 1982 to 21.1 per thousand live births in 1993. The main causes of death in 1993 were perinatal, congenital malformations, diarrhea, and respiratory infections. Low birthweight babies were twelve times more likely

  11. Mortalidade materna por cardiopatia Maternal mortality due to heart disease

    Directory of Open Access Journals (Sweden)

    Helvécio N. Feitosa

    1991-12-01

    Full Text Available Realizou-se estudo retrospectivo da mortalidade materna por cardiopatia, no período de janeiro de 1979 a dezembro de 1989. Dentre um total de 16.423 internações, houve 694 gestantes com o diagnóstico de cardiopatia (4,2%. No mesmo período, ocorreram 51 óbitos maternos, correspondendo a um coeficiente de mortalidade materna de 428,2/100.000 nascidos vivos. Houve 12 óbitos maternos por cardiopatia. A análise estatística permitiu a identificação de alguns fatores associados a maior risco de morte nas pacientes cardiopatas: primeira gravidez, primiparidade, ausência de assistência pré-natal, realização de cirurgia cardíaca anterior à gravidez e/ou na gestação. O maior número de mortes ocorreu no puerpério. A classificação funcional (NYHA não se constituiu em parâmetro seguro para avaliar o prognóstico materno, pois 91,7% dos casos de óbito foram incluídos no grupo considerado favorável (classes I e II ao iniciar a gestação.A retrospective study on maternal mortality in pregnant women with cardiac disease over a period of eleven years (January 1979 to December 1989 was undertaken. The objetive was an analysis of the main aspects of this association. Cardiac disease was diagnosed in 694 patients (4.2% of a total of 16,423 admitted to the Obstetrics Department of the Escola Paulista de Medicina. As for etiology, rheumatic disease (52.3%; Chagas's disease (19.3% and congenital disease (8.1% were the most frequent causes. There were 51 maternal deaths, according to FIGO's definition (1967, corresponding to a maternal mortality rate of 428.2/100,000 livebirths during the same period. Twelve of these maternal deaths were due to cardiac disease (maternal mortality rate of 100.8/100,000 livebirths. The statistical analysis identified the following aspects associated with maternal mortality among patients with cardiac disease: primigravida, lack of adequate prenatal care, and cardiac surgery performed previously to and

  12. To Love—To Live: Barrow and Cart

    Directory of Open Access Journals (Sweden)

    Lisa McDonald

    2013-02-01

    Full Text Available From the residue of meaning, an ensemble of shadows. From the glint of souvenir, pliable impressions. In this paper, we work a poetics of encounter, of being, keeping, homage, of paying homage to fragility, to object and to interspecies—ways are found to engage motion from within and around co-extensive bodies. With the consolation of images, we follow the terse rhythms of routine and street where dwelling is a case of affective dissent. Zones of departure appear through testimony as well as chance, taking their own form. A footfall brings us as observers into quiet spaces which refuse self-estrangement as we travel by way of an unquiet ground. Breath, respiration, aspiration. Precipitation. Sculptures of mist are also the language of lives, of kinship between object, footfall and air. A language of brackets, questions, ellipses. There may be a man, a dog, a barrow. There may be a woman, a cart. Air. How shall this image be made?

  13. CART IV: improving automatic camouflage assessment with assistance methods

    Science.gov (United States)

    Müller, Thomas; Müller, Markus

    2010-04-01

    In order to facilitate systematic, computer aided improvements of camouflage and concealment assessment methods, the software system CART (Camouflage Assessment in Real-Time) was built up for the camouflage assessment of objects in multispectral image sequences (see contributions to SPIE 2007, SPIE 2008 and SPIE 2009 [1], [2], [3]). It comprises a semi-automatic marking of target objects (ground truth generation) including their propagation over the image sequence and the evaluation via user-defined feature extractors. The conspicuity of camouflaged objects due to their movement can be assessed with a purpose-built processing method named MTI snail track algorithm. This paper presents the enhancements over the recent year and addresses procedures to assist the camouflage assessment of moving objects for image data material with strong noise or image artefacts. This extends the evaluation methods significantly to a broader application range. For example, some noisy infrared image data material can be evaluated for the first time by applying the presented methods which fathom the correlations between camouflage assessment, MTI (moving target indication) and dedicated noise filtering.

  14. CART V: recent advancements in computer-aided camouflage assessment

    Science.gov (United States)

    Müller, Thomas; Müller, Markus

    2011-05-01

    In order to facilitate systematic, computer aided improvements of camouflage and concealment assessment methods, the software system CART (Camouflage Assessment in Real-Time) was built up for the camouflage assessment of objects in multispectral image sequences (see contributions to SPIE 2007-2010 [1], [2], [3], [4]). It comprises a semi-automatic marking of target objects (ground truth generation) including their propagation over the image sequence and the evaluation via user-defined feature extractors as well as methods to assess the object's movement conspicuity. In this fifth part in an annual series at the SPIE conference in Orlando, this paper presents the enhancements over the recent year and addresses the camouflage assessment of static and moving objects in multispectral image data that can show noise or image artefacts. The presented methods fathom the correlations between image processing and camouflage assessment. A novel algorithm is presented based on template matching to assess the structural inconspicuity of an object objectively and quantitatively. The results can easily be combined with an MTI (moving target indication) based movement conspicuity assessment function in order to explore the influence of object movement to a camouflage effect in different environments. As the results show, the presented methods contribute to a significant benefit in the field of camouflage assessment.

  15. Intermediate transport in Southeast Asia. [Carts, cycles, mini-buses

    Energy Technology Data Exchange (ETDEWEB)

    Meier, A.K.

    1977-06-01

    Traffic flows through the streets of Southeast Asian countries even though they are used for almost all aspects of human and animal existence. The carts, bicycles, tricycles, and motorcycles, motorized three-wheelers, mini-buses are the so-called intermediate-transport vehicles. It is upon this group of vehicles that a culture--constrained by its own unique economic, environmental, and technological factors--exerts its influence most directly toward the solution of the transport problem. Transportation fills more service roles in Southeast Asian cities than in Western cities. Communication facilities such as telephones and postal services are notoriously unreliable. The personal encounter is all important in social and business interactions in Southeast Asia. Each of the transport modes is examined in view of design and use in a number of specific cultural settings for the countries in Southeast Asia. Present use of intermediate transport in developed countries is discussed briefly, and its further development predicted--pointing out the health and conservation advantages. (MCW)

  16. Avaliação da mortalidade por causas externas

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    Ricardo Alessandro Teixeira Gonsaga

    2012-08-01

    Full Text Available OBJETIVO: Avaliar os óbitos por causas externas em uma microrregião do Estado de São Paulo. MÉTODOS: Estudo descritivo exploratório transversal retrospectivo. Foi feito um levantamento e revisão de 511 prontuários das vítimas de causas externas fornecidos pelo Instituto Médico Legal de Catanduva - SP de 2008 a 2011. Os dados foram classificados por sexo, idade, intencionalidade e mecanismo de causa externa. RESULTADOS: A mortalidade foi predominante no sexo masculino, com 77,9% dos casos (p<0,001. As mortes classificadas como não intencionais representaram 66,9%, enquanto as intencionais, 33,1% (p<0,001. Os acidentes de transporte terrestre foram responsáveis por 45,6% dos casos, sendo a principal causa dos óbitos analisados. O segundo lugar foi atribuído aos suicídios, com 16%, seguido pelos homicídios (13,9%. CONCLUSÃO: Os resultados encontrados diferem dos perfis encontrados em outros estudos brasileiros, aproximando-se mais da realidade de países desenvolvidos, já que a não intencionalidade foi preponderante e as principais causas foram os acidentes de transporte terrestre, suicídios e homicídios, respectivamente. Foi constatada a necessidade de melhorias no preenchimento da declaração de óbito pelos legistas, visto que isto foi uma dificuldade encontrada pelos autores na realização do estudo.

  17. Desigualdades en mortalidad en la ciudad de Sevilla Inequalities in mortality in Seville [Spain

    Directory of Open Access Journals (Sweden)

    Miguel Ruiz-Ramos

    2004-02-01

    Full Text Available Objetivos: Describir las desigualdades sociales respecto a la mortalidad en la ciudad de Sevilla en el período 1994-1998, según el nivel socioeconómico. Métodos: Con las defunciones y las poblaciones de Sevilla agregadas por zonas básicas de salud (ZBS, se ha calculado la esperanza de vida, las tasas brutas y ajustadas por edad de la mortalidad general y por causas, y de años potenciales de vida perdidos; con los porcentajes de desempleo en varones, se han dividido las ZBS en 3 niveles, y mediante modelos de regresión de Poisson se han estimado los riesgos relativos (RR de mortalidad general y por causas en cada uno de los niveles para varones y mujeres; asimismo, se han relacionado los porcentajes de desempleo de cada una de las ZBS con la mortalidad general y algunas causas de muerte. Resultados: Existían unas diferencias de 7,9 y 4,6 años, para varones y mujeres respectivamente, en la esperanza de vida al nacer entre las ZBS de menor y mayor mortalidad. En años potenciales de vida perdidos, las zonas de mayor mortalidad presentaron 4,1 veces más mortalidad en los varones y 2,6 veces en las mujeres que las de menor mortalidad. La mortalidad general aumentaba a medida que se incrementaban los porcentajes de desempleo: las ZBS con porcentajes de desempleo más elevados tuvieron un 15% más de mortalidad que las de menor desempleo en los varones y un 6% en las mujeres. Por causas, el sida fue la enfermedad que mayores desigualdades presentó en mortalidad, tanto en varones como en mujeres. Conclusiones: La ciudad de Sevilla en el período 1994-1998 presenta importantes desigualdades por ZBS en la mortalidad general, la mortalidad prematura y por causas. Las desigualdades se dan tanto en los varones como en las mujeres, aunque su magnitud es mayor en los varones. Existe una clara asociación entre los niveles socioeconómicos y la mortalidad.Objectives: To describe social inequalities in mortality in Seville from 1994 to 1998 according

  18. Perfil de la casuística hospitalaria de la población inmigrante en Barcelona

    Directory of Open Access Journals (Sweden)

    Cots F.

    2002-01-01

    Full Text Available Objetivo: A pesar de que en los últimos 5 años la población inmigrante se ha triplicado en ciudades como Barcelona, hasta el momento no se ha evaluado de forma rigurosa el impacto de este colectivo en el sistema sanitario. El objetivo del presente estudio ha sido comparar el perfil de la hospitalización de la población inmigrante con la autóctona, desde el punto de vista de la casuística, gravedad, características demográficas y consumo de estancias. Material y métodos: Se han analizado las 15.057 altas del Hospital del Mar de Barcelona en el año 2000. Este hospital asiste el 60% de los ingresos hospitalarios del distrito de Ciutat Vella, distrito que presentaba en el año 2000 un porcentaje de inmigrantes residentes del 21%. Se han comparado las características sociodemográficas y de casuística de los pacientes en razón de ser o no inmigrantes. También se ha comparado el consumo de recursos hospitalarios teniendo en cuenta la edad, la casuística (grupos relacionados por el diagnóstico y la gravedad (severidad, complicaciones y comorbilidades de la patología atendida. Resultados: La población inmigrante ha presentado una casuística distinta de la autóctona por la marcada diferencia en la edad y por su mayor tasa de fecundidad. El 33% de los ingresos de inmigrantes han sido partos. El coste medio de las altas de inmigrantes de países de renta baja valorado en consumo de estancias hospitalarias, ha sido un 30% menor que el del resto de las altas. Una vez ajustadas la edad, la casuística y la severidad, el consumo de estancias hospitalarias en la población inmigrante ha sido significativamente menor. La diferencia se ha cifrado en un 5% cuando sólo se ha ajustado por patología y en un 10% cuando han sido considerados todos los factores. Conclusiones: Las diferencias en la casuística vienen marcadas por la edad y por las diferencias socioculturales. La pirámide de edad de la población hospitalaria inmigrante recompone

  19. CART and Reverse CART Technique in the Retrograde Percutaneous Coronary Intervention of Chronic Total Occlusion%CART和反向CART技术在逆向PCI中的应用

    Institute of Scientific and Technical Information of China (English)

    孙党辉; 李悦

    2011-01-01

    控制性正向-逆向内膜下寻径(CART)和反向CART技术是近年来慢性完全闭塞病变介入治疗重要的技术进展,大大提高了慢性完全闭塞病变经皮冠状动脉介入治疗(PCI)成功率.CART和反向CART技术的开展要求术者具有较丰富的正向PCI操作经验,根据自身技术能力、设备条件和患者病变特点合理选择恰当的PCI治疗技术.在血管内超声指导下反向CART技术的应用进一步提高了手术的成功率和安全性.%CART and reverse CART technique are considered as the important current techniques in percutaneous coronary interven-tion for chronic total occlusion, and have great improved success rates of the recanalization of the chronic total occlusion. IVUS-guided re-verse CART could further elevate the success rate and safety of CTO recanalization. Because of the learning-carve, the operator should per-form antegrade recanalization well first, and choose best way according to the skill of the operator,and the facilities and the lesion condition.

  20. Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysis

    OpenAIRE

    Jaworski, Jason N.; Kimmel, Heather L.; Mitrano, Darlene A.; Tallarida, Ronald J.; Kuhar, Michael J

    2007-01-01

    CART (cocaine- and amphetamine-regulated transcript) peptides appear to be mediators or modulators of psychostimulant drugs. An interesting result in the nucleus accumbens has been that injection of CART peptide has no effect by itself on locomotor activity, but it reduces the locomotor activity induced by cocaine or amphetamine. However, in the ventral tegmental area (VTA), injections of CART peptide have been shown to increase locomotor activity, although to a lesser degree (Kimmel et al. 2...

  1. Factores pronósticos de morbi-mortalidad en nutrición enteral hospitalaria: estudio prospectivo Prognostic morbidity and mortality factors in hospital enteral nutrition: prospective study

    Directory of Open Access Journals (Sweden)

    O. Moreno Pérez

    2005-06-01

    Full Text Available Objetivos: Determinar aquellos factores pronósticos que mejor puedan prever el resultado de una intervención nutricional vía enteral y evaluar la calidad asistencial de una unidad de nutrición. Ámbito y sujetos: Pacientes que precisaron nutrición enteral en régimen de ingreso hospitalario, en un centro de 3.er nivel. Intervenciones: Estudio observacional, prospectivo, en el que se incluyeron 160 pacientes mediante muestreo consecutivo, durante un período de seguimiento de 6 meses. Se determinó: patología de base, grado de incapacidad, valoración nutricional, tipo de nutrición enteral, complicaciones, cuidados de enfermería y evolución clínica de los pacientes. Resultados: Se diagnosticó desnutrición calórica y protéica graves en el 48,4 y 52,9% de los pacientes; el grado de estrés fue moderado en el 52,2% y grave en el 36,5%. En el 88,2% de los pacientes la variación de los parámetros protéicos fueron de igual o mejor, con un incremento en las concentraciones de albúmina de 0,26 g/dl y prealbúmina de 2,4 mg/dl (p Objective: To determine the prognostic factors that may best for see the outcome of an enteral nutritional intervention and to assess the assistance quality of a nutrition unit. Setting and subjects: Patients that required enteral nutrition during hospital admission at a third level center. Interventions: observational prospective study in which 160 patients were included by means of consecutive sampling, for a 6-months follow-up period. Underlying pathology, disability degree, nutritional assessment, type of enteral nutrition, complications, nursing care, and clinical course of patients were determined. Results: severe caloric and protein hyponutrition was diagnosed in 48.4 and 52.9% of patients; stress degree was moderate in 52.2% and severe in 36.5%. In 88.2% of patients variation of protein parameters was unchanged or improved, with a 0.26 g/dL increase in albumin levels and 2.4 m/dL in prealbumin (p < 0.05. Multivariate analysis adjusted for plasma albumin at admission showed that besides this biochemical parameter, a severe stress degree, a decreased alertness level, and worsening of protein variation during admission are independent prognostic mortality factors during an enteral nutritional intervention in the hospitalized patient (p < 0.05. Conclusions: alertness level, degree of caloric hyponutrition, stress degree, plasma albumin levels, and variation of protein parameters during nutritional support are independent prognostic factors for the nutritional intervention outcomes. The development of global monitoring systems of assistance activity and quality of Nutrition Units is paramount in order to improve the efficiency of enteral nutritional support at the hospital setting, to advance in patients care and promote the development of nutritional therapy.

  2. Factores pronósticos de morbi-mortalidad en nutrición enteral hospitalaria: estudio prospectivo Prognostic morbidity and mortality factors in hospital enteral nutrition: prospective study

    OpenAIRE

    O. Moreno Pérez; A. Meoro Avilés; A. Martínez; Boix, E.; S.; Aznar; M.ª D. Martín; A. M. Picó

    2005-01-01

    Objetivos: Determinar aquellos factores pronósticos que mejor puedan prever el resultado de una intervención nutricional vía enteral y evaluar la calidad asistencial de una unidad de nutrición. Ámbito y sujetos: Pacientes que precisaron nutrición enteral en régimen de ingreso hospitalario, en un centro de 3.er nivel. Intervenciones: Estudio observacional, prospectivo, en el que se incluyeron 160 pacientes mediante muestreo consecutivo, durante un período de seguimiento de 6 meses. Se determin...

  3. Combined atmospheric radiative transfer (CART) model and its applications%通用大气辐射传输软件(CART)及其应用

    Institute of Scientific and Technical Information of China (English)

    魏合理; 陈秀红; 戴聪明

    2012-01-01

    大气光谱透过率和背景辐射的计算在诸如大气遥感、光电工程等领域有重要应用.根据所提出的中分辨率大气分子吸收快速计算方法、大气气溶胶衰减计算方法、大气多次散射快速算法,研制了一套通用大气辐射传输计算软件(CART),该软件可根据大气参数快速计算可见光到远红外波段的大气光谱透过率和大气背景辐射,光谱分辨率1 cm-1,覆盖可见光到远红外波段.介绍了该软件的计算模型、主要功能和计算实例、部分实际验证结果以及应用领域.CART在目标辐射特性测量的大气修正、光电设备的设计和性能评估将有广泛的应用.%The atmospheric spectral transmittance and background radiance have important applications in many research areas, such as atmospheric remote sensing, optical-electronical engineering, etc. Based on our algorithms of fast computation of atmospheric molecular absorptions, the aerosol extinction, and atmospheric multiple -scattering, a combined atmospheric radiative transfer (CART) software was developed. The CART was used to compute atmospheric spectral transmittance and background radiance from visible to far infrared wavelength range efficiently, the spectral resolution of the CART is 1 cm-1. The algorithms, the computation functions, and some calculating examples of the CART were introduced. Some experimental results for the validation of the CART were also shown. CART could be used in many fields such as atmospheric transmittance correction for target radiative characteristics measurements, the design and performance evaluation of optic-electronic devices, etc.

  4. Blood serum levels of CART peptide in patients with schizophrenia on clozapine monotherapy.

    Science.gov (United States)

    Wysokiński, Adam; Kłoszewska, Iwona

    2014-12-15

    CART (cocaine- and amphetamine-regulated transcript) is an endogenous inhibitor of food intake. We compared fasting serum CART levels in subjects with schizophrenia on clozapine monotherapy (n=24) with sex- and age-matched healthy controls (n=24). CART levels were higher in the clozapine group (262.76±359.91 vs. 90.40±169.90 pg/mL). CART levels were higher in subjects with metabolic syndrome compared to subjects without metabolic syndrome in the clozapine group (415.63±416.93 vs. 122.62±237.17 pg/mL, n=12 and 12, respectively) and in the whole study group (377.73±401.09 vs. 88.58±172.35 pg/mL, n=16 and 32, respectively). In the control group CART levels were higher in subjects with total body fat lower than the target maximum compared to subjects with total body fat below the target maximum (121.71±154.91 vs. 66.32±182.96 pg/mL, n=14 and 10, respectively). CART levels did not correlate with age, weight, BMI, abdominal, waist and hip circumferences, WHR, blood pressure, laboratory tests, clozapine dose, antipsychotic or clozapine treatment duration, body composition, and markers of insulin resistance in the study group. Further studies are required to confirm whether increased levels of circulating CART are compensatory in response to treatment-induced weight gain and abdominal obesity or a primary feature of schizophrenia.

  5. Pequenos para idade gestacional: fator de risco para mortalidade neonatal

    Directory of Open Access Journals (Sweden)

    Almeida Márcia Furquim de

    1998-01-01

    Full Text Available OBJETIVO: Estudar as variáveis contempladas na Declaração de Nascimento (DN como possíveis fatores de risco para nascimentos pequenos para a idade gestacional (PIG e o retardo de crescimento intra-uterino como fator de risco para a mortalidade neonatal. MATERIAL E MÉTODO: As variáveis existentes na DN foram obtidas diretamente de prontuários hospitalares. Os dados referem-se a uma coorte de nascimentos obtida por meio da vinculação das declarações de nascimento e óbito, correspondendo a 2.251 nascimentos vivos hospitalares, de mães residentes, ocorridos no Município de Santo André, Região Metropolitana de São Paulo, no período de l/1 a 30/6/1992, e aos óbitos neonatais verificados nessa coorte. RESULTADOS: Obteve-se a proporção de 4,3% de nascimentos PIG, significativamente maior entre os recém-nascidos de pré-termo e pós-termo, entre os nascimentos cujas mães tinham mais de 35 anos de idade e grau de instrução inferior ao primeiro grau completo. Os recém-nascidos PIG apresentam maior risco de morte neonatal que aqueles que não apresentavam sinais de retardo de crescimento intra-uterino. CONCLUSÕES: Em áreas com menor freqüência de baixo peso ao nascer, é importante investigar a presença de retardo de crescimento intra-uterino entre os nascimentos prematuros e não apenas nos nascimentos de termo. O registro da data da última menstruação (ou da idade gestacional em semanas não agregadas na DN facilitaria a detecção de PIGs na população de recém-nascidos.

  6. Consistent computation of the age of water parcels using CART

    Science.gov (United States)

    Mercier, Ch.; Delhez, E. J. M.

    The Constituent-oriented Age and Residence time Theory (CART) provides a flexible and efficient framework to diagnose the dynamics of marine systems. Beside the equation for the concentration of appropriate (real or artificial) tracers, the method requires the resolution of differential problems for the so-called age concentration of each of these tracers. Thanks to its Eulerian formulation as an advection/diffusion problem with source terms, the method is easily implemented in existing models. However, some numerical artifacts should be avoided in order to produce physically meaningful results leading to a better understanding of the system under study. In this paper, we address two such issues that are related to the degree of implicitness of the different terms and to the advection scheme. To enforce the consistency between the discrete equations for the concentration of a tracer and for its age concentration, the degree of implicitness must be identical in the source/sink terms of the two equations. However, the ageing term should be computed in a completely explicit (respectively implicit) way if the discretization of the source/sink terms is implicit in time (respectively explicit). A specific attention should also be paid to the advection schemes for the concentration and the age concentration. The raw application of Total Variation Diminishing (TVD) scheme for both equations can lead to the occurrence of artificial local extreme values and spatial oscillations of the age field. While the TVD behavior of the discrete age field cannot be guaranteed, appropriate modifications of the flux/slope limiters used in the TVD schemes can be implemented to enforce a maximum principle that prevents the occurrence of age values outside the physically acceptable range.

  7. Parallelization of a three-dimensional whole core transport code DeCART

    Energy Technology Data Exchange (ETDEWEB)

    Jin Young, Cho; Han Gyu, Joo; Ha Yong, Kim; Moon-Hee, Chang [Korea Atomic Energy Research Institute, Yuseong-gu, Daejon (Korea, Republic of)

    2003-07-01

    Parallelization of the DeCART (deterministic core analysis based on ray tracing) code is presented that reduces the computational burden of the tremendous computing time and memory required in three-dimensional whole core transport calculations. The parallelization employs the concept of MPI grouping and the MPI/OpenMP mixed scheme as well. Since most of the computing time and memory are used in MOC (method of characteristics) and the multi-group CMFD (coarse mesh finite difference) calculation in DeCART, variables and subroutines related to these two modules are the primary targets for parallelization. Specifically, the ray tracing module was parallelized using a planar domain decomposition scheme and an angular domain decomposition scheme. The parallel performance of the DeCART code is evaluated by solving a rodded variation of the C5G7MOX three dimensional benchmark problem and a simplified three-dimensional SMART PWR core problem. In C5G7MOX problem with 24 CPUs, a speedup of maximum 21 is obtained on an IBM Regatta machine and 22 on a LINUX Cluster in the MOC kernel, which indicates good parallel performance of the DeCART code. In the simplified SMART problem, the memory requirement of about 11 GBytes in the single processor cases reduces to 940 Mbytes with 24 processors, which means that the DeCART code can now solve large core problems with affordable LINUX clusters. (authors)

  8. Both neuropeptide Y knockdown and Y1 receptor inhibition modulate CART-mediated appetite control.

    Science.gov (United States)

    Chu, Shu-Chen; Chen, Pei-Ni; Ho, Ying-Jui; Yu, Ching-Han; Hsieh, Yih-Shou; Kuo, Dong-Yih

    2015-01-01

    Amphetamine (AMPH)-induced appetite suppression has been attributed to its inhibition of neuropeptide Y (NPY)-containing neurons in the hypothalamus. This study examined whether hypothalamic cocaine- and amphetamine-regulated transcript (CART)-containing neurons and NPY Y1 receptor (Y1R) were involved in the action of AMPH. Rats were treated daily with AMPH for four days, and changes in feeding behavior and expression levels of NPY, CART, and POMC were assessed and compared. The results showed that both feeding behavior and NPY expression decreased during AMPH treatment, with the biggest reduction occurring on Day 2. By contrast, the expression of CART and melanocortin 3 receptor (MC3R), a member of the POMC neurotransmission, increased with the maximum response on Day 2, directly opposite to the NPY expression results. The intracerebroventricular infusion of NPY antisense or Y1R inhibitor both modulated AMPH-induced anorexia and the expression levels of MC3R and CART. The results suggest that in the hypothalamus both POMC- and CART-containing neurons participate in regulating NPY-mediated appetite control during AMPH treatment. These results may advance the knowledge of molecular mechanism of anorectic drugs.

  9. Active-passive vibration absorber of beam-cart-seesaw system with piezoelectric transducers

    Science.gov (United States)

    Lin, J.; Huang, C. J.; Chang, Julian; Wang, S.-W.

    2010-09-01

    In contrast with fully controllable systems, a super articulated mechanical system (SAMS) is a controlled underactuated mechanical system in which the dimensions of the configuration space exceed the dimensions of the control input space. The objectives of the research are to develop a novel SAMS model which is called beam-cart-seesaw system, and renovate a novel approach for achieving a high performance active-passive piezoelectric vibration absorber for such system. The system consists of two mobile carts, which are coupled via rack and pinion mechanics to two parallel tracks mounted on pneumatic rodless cylinders. One cart carries an elastic beam, and the other cart acts as a counterbalance. One adjustable counterweight mass is also installed underneath the seesaw to serve as a passive damping mechanism to absorb impact and shock energy. The motion and control of a Bernoulli-Euler beam subjected to the modified cart/seesaw system are analyzed first. Moreover, gray relational grade is utilized to investigate the sensitivity of tuning the active proportional-integral-derivative (PID) controller to achieve desired vibration suppression performance. Consequently, it is shown that the active-passive vibration absorber can not only provide passive damping, but can also enhance the active action authority. The proposed software/hardware platform can also be profitable for the standardization of laboratory equipment, as well as for the development of entertainment tools.

  10. La percepcion de las familias ante la animacion hospitalaria: estudio realizado en el Hospital Materno-Infantil de Oviedo

    Directory of Open Access Journals (Sweden)

    M Teresa Bermudez Rey

    2012-07-01

    Full Text Available En estas líneas se recoge parte de una investigación financiada por la Universidad de Oviedo, sobre la animación realizada en las plantas de Pediatría del Hospital Materno-Infantil de la capital asturiana.La animación hospitalaria es llevada a cabo por asociaciones de voluntariado de reconocida trayectoria: CRUZ ROJA, GALBÁN, (que realiza sólo animación con pacientes pediátricos oncológicos, Voluntariado de la Fundación “la Caixa” (que abre las puertas de las ciber@ulas a todos los niños ingresados en el centro sanitario y SED (Solidaridad, Educación y Desarrollo,En concreto se hace referencia a la opinión de los padres de niños hospitalizados sobre el empleo del tiempo libre de los enfermos, en el que se recogían aspectos como la ocupación del paciente en el tiempo libre; con quién lo comparte; el lugar de juego; la influencia, dedicación y relación con el voluntariado; los efectos que la animación  tiene sobre los enfermos y las familias; la existencia de animación con los hermanos del paciente pediátrico; así como las  características físicas que a su juicio, debieran reunir  tanto el hospital como  las habitaciones de los enfermos.El análisis del estudio, permite identificar la gran aceptación que los padres de los pacientes pediátricos muestran, con respecto a la animación hospitalaria llevada a cabo en el hospital por las cuatro asociaciones antes mencionadas, y pone de manifiesto las consecuencias positivas derivadas de la realización de la misma.Estos resultados avalan la necesidad de profesionalizar la animación hospitalaria, sin que ello suponga prescindir de las valiosas aportaciones del voluntariado. En  consonancia con lo cual se trazan unas líneas generales de actuación.

  11. Co-expression patterns of cocaine- and amphetamine-regulated transcript (CART) with neuropeptides in dorsal root ganglia of the pig.

    Science.gov (United States)

    Zacharko-Siembida, Anna; Kulik, Paweł; Szalak, Radosław; Lalak, Roman; Arciszewski, Marcin Bartłomiej

    2014-03-01

    In the present study the neuronal distribution of CART was evaluated immunohistochemically in porcine dorsal root ganglia (DRGs). In co-localization studies the co-expression patterns of CART with SP, CGRP, galanin, CALB and LENK were investigated by means of triple immunohistochemical stainings. In porcine DRGs, the expression of CART was found in approximately 5% of primary sensory neurons. The vast majority (ca. 95%) of CART-immunoreactive (IR) neurons were small and middle sized, and only 5% were categorized as large. CART-IR neurons additionally exhibiting the presence of SP/CGRP (ca. 12%), SP/CALB (ca. 12%), SP/LENK (ca. 5%) were found. The vast majority of CART-IR/CGRP-IR neurons did not display immunoreaction to SP (ca. 60%). Subclasses of CART-IR/LENK-IR/SP-negative (ca. 5%), as well as CART-IR/CALB-IR/SP-negative neurons (ca. 10%), were also visualized. In addition, CART-IR neurons with no immunoreactivities to any of the neuropeptides studied were also shown. In porcine DRGs none of the CART-IR neurons exhibited the presence of galanin. The results obtained in the study suggest that CART may functionally modulate the activity of the porcine primary sensory neurons. It is concluded that co-expression of CART with CGRP, SP, LENK and CALB in subsets of the pig L1-L6 DRGs neurons provide anatomical evidence for a CART role in pain processing.

  12. Creación de índices de gestión hospitalaria mediante análisis de componentes principales Construction of hospital management indices using principal component analysis

    Directory of Open Access Journals (Sweden)

    José Almenara-Barrios

    2002-11-01

    Full Text Available Objetivo. Obtener índices útiles para la gestión hospitalaria basados en técnicas estadísticas multivariantes descriptivas. Material y métodos. Durante 1999 y 2000 se recogió información del Hospital de Algeciras correspondiente a los ingresos hospitalarios del periodo 1997-1998. Se estudiaron las variables habitualmente monitorizadas por el Servicio Andaluz de Salud, del Sistema Nacional de Salud Español: número de ingresos, mortalidad, número de reingresos, número de consultas externas, índice case-mix, número de estancias e índice funcional. Las variables se midieron en un total de 22 486 ingresos. Aplicamos la técnica de análisis de componentes principales (ACP, y se utilizó la matriz de correlaciones R. Resultados. Se seleccionaron las dos primeras componentes, con un porcentaje acumulado de variabilidad de 62.67%. Conclusiones. La primera componente puede ser asimilada a un nuevo índice que tiene que ver con la cuantía de personas atendidas, llamado demanda asistencial. La segunda explicaría la dificultad de los casos atendidos; le hemos llamado complejidad asistencial. Ambos índices permiten dar una clasificación de los servicios hospitalarios.Objective. To construct useful indices for hospital management, based on descriptive multivariate techniques. Material and Methods. Data were collected during 1999 and 2000, on hospital admissions occurring during 1997-1998 at Hospital General de Algeciras, part of Servicio Andaluz de Salud (SAS of Sistema Nacional de Salud Español (Spanish National Health Service. The following variables routinely monitored by health authorities were analyzed: number of admissions, mortality, number of re-admissions, number of outpatient consultations, case-mix index, number of stays, and functional index. Variables were measured in a total of 22486 admissions. We applied the Principal Components Analysis (PCA method using the R correlation matrix. Results. The first two components were

  13. Mortalidad por defectos del tubo neural en México, 1980-1997

    Directory of Open Access Journals (Sweden)

    Ramírez-Espitia José A

    2003-01-01

    Full Text Available OBJETIVO: Describir la mortalidad en México por defectos del tubo neural, durante el periodo 1980-1997. MATERIAL Y MÉTODOS: Las tasas anuales de mortalidad estatales y nacionales, por defectos del tubo neural, se calcularon por 10 000 nacidos vivos. La tendencia temporal fue evaluada por el porcentaje de cambio anual obtenido mediante un modelo de regresión de Poisson. Se calculó la razón de mortalidad, tomando la media nacional como referencia. Las tasas y las razones se representaron gráficamente en mapas. RESULTADOS: Durante el periodo la tasa bruta de mortalidad por defectos del tubo neural fue de 5.8 por 10 000 nacidos vivos. La anencefalia fue el tipo de defecto más frecuente (37.7%, seguida de la espina bífida sin hidrocefalia (31.6%. La tendencia nacional de la mortalidad por defectos del tubo neural fue ascendente entre 1980 y 1990 (porcentaje de cambio anual 7.5 IC 95% 6.5, 8.6 y descendente entre 1990-1997 (porcentaje de cambio anual -2.3 IC 95% -3.6, -0.9. CONCLUSIONES: Las altas tasas de mortalidad por defectos del tubo neural fueron debidas principalmente a la elevada frecuencia de las anencefalias. El incremento observado parece no ser sólo atribuible a cuestiones puramente diagnósticas o de mejora en los registros. La influencia de factores asociados a estos defectos, como determinados polimorfismos genéticos, la deficiencia de ácido fólico, la obesidad materna, la exposición laboral a plaguicidas y la pobreza deberán evaluarse mediante estudios específicos.

  14. Depletion methodology in the 3-D whole core transport code DeCART

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kang Seog; Cho, Jin Young; Zee, Sung Quun

    2005-02-01

    Three dimensional whole-core transport code DeCART has been developed to include a characteristics of the numerical reactor to replace partly the experiment. This code adopts the deterministic method in simulating the neutron behavior with the least assumption and approximation. This neutronic code is also coupled with the thermal hydraulic code CFD and the thermo mechanical code to simulate the combined effects. Depletion module has been implemented in DeCART code to predict the depleted composition in the fuel. The exponential matrix method of ORIGEN-2 has been used for the depletion calculation. The library of including decay constants, yield matrix and others has been used and greatly simplified for the calculation efficiency. This report summarizes the theoretical backgrounds and includes the verification of the depletion module in DeCART by performing the benchmark calculations.

  15. Neurotransmitter CART as a New Therapeutic Candidate for Parkinson’s Disease

    Directory of Open Access Journals (Sweden)

    Philippe Thuillier

    2013-01-01

    Full Text Available Parkinson’s disease (PD is one of the most common neurodegenerative diseases. To date, there is no effective treatment that halts its progression. Increasing evidence indicates that mitochondria play an important role in the development of PD. Hence mitochondria-targeted approaches or agents may have therapeutic promise for treatment of the disease. Neuropeptide CART (cocaine-amphetamine-regulated transcript, a hypothalamus and midbrain enriched neurotransmitter with an antioxidant property, can be found in mitochondria, which is the main source of reactive oxygen species. Systemic administration of CART has been found to ameliorate dopaminergic neuronal loss and improve motor functions in a mouse model of PD. In this article, we summarize recent progress in studies investigating the relationship between CART, dopamine, and the pathophysiology of PD, with a focus on mitochondria-related topics.

  16. The use of ZIP and CART to model cryptosporidiosis in relation to climatic variables

    Science.gov (United States)

    Hu, Wenbiao; Mengersen, Kerrie; Fu, Shiu-Yun; Tong, Shilu

    2010-07-01

    This research assesses the potential impact of weekly weather variability on the incidence of cryptosporidiosis disease using time series zero-inflated Poisson (ZIP) and classification and regression tree (CART) models. Data on weather variables, notified cryptosporidiosis cases and population size in Brisbane were supplied by the Australian Bureau of Meteorology, Queensland Department of Health, and Australian Bureau of Statistics, respectively. Both time series ZIP and CART models show a clear association between weather variables (maximum temperature, relative humidity, rainfall and wind speed) and cryptosporidiosis disease. The time series CART models indicated that, when weekly maximum temperature exceeded 31°C and relative humidity was less than 63%, the relative risk of cryptosporidiosis rose by 13.64 (expected morbidity: 39.4; 95% confidence interval: 30.9-47.9). These findings may have applications as a decision support tool in planning disease control and risk-management programs for cryptosporidiosis disease.

  17. Golf cart prototype development and navigation simulation using ROS and Gazebo

    Directory of Open Access Journals (Sweden)

    Shimchik Ilya

    2016-01-01

    Full Text Available This paper presents our approach to development of an autonomous golf cart, which will navigate in inaccessible by regular vehicles private areas. For this purpose, we have built a virtual golf course terrain and golf cart model in Gazebo, selected and modernized ROS-based packages in order to use them with Ackermann steering vehicle simulation. To verify our simulation and algorithms, we navigated the golf cart model from one golf hole to another within a virtual 3D golf course. For the real world algorithms’ verification, we developed a small-size vehicle prototype based on Traxxas radio-controlled car model, which is equipped with an on-board controller and sensors. The autonomous navigation of Traxxas-based vehicle prototype has been tested in indoor environment, where it utilized sensory data about environment and vehicle states, and performed localization, optimal trajectory computation and dynamic obstacles’ recognition with adjusting the route in real time.

  18. Classification and regression trees (CART) for estimation of prognosis in patients with gastric carcinoma.

    Science.gov (United States)

    Hermanek, P; Guggenmoos-Holzmann, I

    1994-01-01

    A total of 961 patients who had received resective surgery for gastric carcinoma were grouped according to prognosis by classification and regression trees (CART). This grouping was compared to the present UICC stage grouping. For patients resected for cure (R0) the CART approach allows a better discrimination of patients with poor prognosis (5-year survival rates 15%-30%) from patients with a 5-year survival of 50%, on the one hand, and from patients with extremely poor prognosis (5-year survival rates below 5%) on the other. In the present investigation CART grouping was not influenced by the differentiation between pT1 and pT2 or between pT3 and pT4.

  19. Factores relacionados con la mortalidad intrahospitalaria en el infarto agudo del miocardio

    OpenAIRE

    Yanier Coll Muñoz; Jorge Ruíz Mendoza; Juan José Navarro; Lázaro de la Cruz Avilés; Francisco Valladares Carvajal

    2012-01-01

    Fundamento: la identificación de los factores relacionados con la mortalidad en el infarto agudo del miocardio representa un eslabón primordial en la evaluación inicial de los pacientes. Objetivo: identificar los factores relacionados con la mortalidad intrahospitalaria de los pacientes con infarto agudo del miocardio, ingresados en la Unidad de Cuidados Intensivos Coronarios de Cienfuegos durante el año 2010. Método: se realizó un estudio de serie de casos, que incluyó 241 pacientes con dia...

  20. Estados de salud y descenso de la mortalidad: un espacio para la multidisciplinariedad

    OpenAIRE

    Bernabeu Mestre, Josep

    1999-01-01

    Tras exponer las principales características del debate sobre las causas o factores que explican el descenso de la mortalidad que acompañó la transición demográfica de la población europea occidental, el trabajo propone introducir en dicho debate, el concepto de estado de salud como categoría de análisis, al mismo tiempo que justifica su validez para abordar la variedad de factores que encierra la transición de la mortalidad. Por último, a título de ejemplo, se abordan algunos de los recursos...

  1. Tendencias en los ingresos hospitalarios y mortalidad por asma en nuestra comunidad

    OpenAIRE

    Aboal Viñas, Jorge

    2014-01-01

    OBJETIVOS: Analizar la tendencia de los ingresos hospitalarios y la mortalidad por asma en la población de nuestra comunidad a lo largo de 15 años. Asimismo, se evaluará la influencia del polen ambiental en los ingresos por asma de nuestra área sanitaria. METODOS: Análisis retrospectivo de los ingresos hospitalarios y de la mortalidad por asma en nuestra comunidad a lo largo de 15 años. El análisis de los ingresos hospitalarios se hará de forma diferenciada para la poblac...

  2. Mortalidade perinatal no municipio de Salvador, Bahia: evolucao de 2000 a 2009

    Directory of Open Access Journals (Sweden)

    Elsa Jacinto

    2013-10-01

    Full Text Available OBJETIVO Analisar a evolução da mortalidade perinatal quanto à dimensão do problema e sua extensão. MÉTODOS Estudo descritivo de tendência temporal com 10.994 óbitos perinatais, de mães residentes em Salvador, BA, com idade gestacional ≥ 22 semanas, idade do recém-nascido até seis dias e 500 g ou mais de peso ao nascer, registrados de 2000 a 2009. Utilizaram-se dados do Sistema de Informações de Nascidos Vivos e do Sistema de Informações sobre Mortalidade do sitio eletrônico do Datasus/Ministério da Saúde. Calcularam-se taxas de mortalidade perinatal e fetal/1.000 nascimentos e neonatal precoce/1.000 nascidos vivos. Aplicaram-se: teste Qui-quadrado de Pearson para diferenças em proporções, teste de sequências ( runs , cálculo de médias móveis e coeficiente de determinação linear (R 2 para análise de tendência. Utilizou-se a classificação de Wigglesworth para causas de morte. RESULTADOS A taxa de mortalidade perinatal mostrou tendência decrescente, sendo reduzida em 42,0% no período (de 33,1 (2000 para 19,2 (2009, com maior contribuição da taxa neonatal precoce (-56,3%. A mortalidade fetal representou grande proporção (61,9% da taxa de mortalidade perinatal em 2009. A classificação dos óbitos apontou como causas mais frequentes de óbito perinatal: asfixia intraparto (8,8/1.000, imaturidade (7,1/1.000 e malformações congênitas (1,3/1.000. CONCLUSÕES Mesmo em declínio, a taxa de mortalidade perinatal continua elevada e o predomínio recente da mortalidade fetal indica mudança no perfil de causas e impacto nas ações de prevenção. A consulta pré-natal de qualidade com controle de riscos e melhoria da assistência ao parto pode reduzir a ocorrência de causas evitáveis.

  3. Escalas Preditivas de Mortalidade em Cuidados Intensivos Pediátricos

    OpenAIRE

    Oom, Paulo

    2014-01-01

    As escalas preditjvas de mortalidade têm sido utilizadas com uma frequência crescente na avaliação da qualidade da assistência prestada a crianças internadas em unidades de cuidados intensivos, na estratificação de doentes em projectos de investigação clínica e no apoio a algumas decisões clínicas individuais. Existem actualmente dois modelos predidvos de mortalidade para utilização era cuidados intensivos pediátricos a Pediatric Risk of Mortality (PRISM) e a Pediatria Index of Mortality (PTM...

  4. Colecistectomía en cirróticos: Factores asociados a morbilidad y mortalidad

    OpenAIRE

    2007-01-01

    Introducción: Los enfermos cirróticos tienen una mayor prevalencia de colelitiasis y una mayor morbilidad y mortalidad quirúrgica que la población general. Objetivos: Evaluar y determinar factores predictores de morbilidad y mortalidad por colecistectomía en pacientes cirróticos. Material y métodos: Estudio retrospectivo de 23 enfermos con cirrosis hepática sometidos a colecistectomía entre 2000 y 2006 en el Hospital Clínico de la P. Universidad Católica. En cada paciente se evaluaron parámet...

  5. HISTORIAS DENTRO DEL HOSPITAL: TALLER DE ANIMACION A LA LECTURA Y ESCRITURA EN EL AULA HOSPITALARIA RAMON Y CAJAL

    OpenAIRE

    RAMIREZ VEGA ; CHENDA FRANCISCA

    2010-01-01

    El siguiente proyecto de innovación tiene como propósito contribuir a la mejora de la calidad de vida de los niños y adolescentes de entre 3 años a 16 años que presentan una enfermedad aguda o crónica que asisten al Aula Hospitalaria Ramón y Cajal. Se pretende contribuir a la mejora de la calidad de vida de estos niños y adolescentes durante su estadía en el Hospital, a través de la participación activa en las actividades del Taller de animación a la lectura y escritura "His...

  6. Mortalidad atribuible al consumo de tabaco en México

    Directory of Open Access Journals (Sweden)

    Pablo Kuri-Morales

    2002-01-01

    Full Text Available Objetivo. Estudiar la asociación entre defunciones registradas en la delegación Coyoacán y consumo de tabaco y alcohol. Material y métodos. Estudio de mortalidad proporcional y determinación de fracción atribuible en una cohorte de sujetos de la ciudad de México, D.F., México. Se reunió información de todas las defunciones de 1998 captadas a través del Sistema Estadístico y Epidemiológico de las Defunciones (SEED en la delegación Coyoacán, clasificándolas por diagnóstico en enfermedades del sistema circulatorio (ESC, sistema respiratorio (EPOC, neoplasias (NEO. Se encuestó a familiares de los fallecidos sobre consumo de tabaco y alcohol. Resultados. Fumar los últimos 10 años de vida fue significativo para ESC en hombres de 70 años y más (RM: 2.06, IC 95%=1.18-3.58; y continuar fumando el último año de vida fue significativo para NEO y para EPOC en mujeres de 70 años y más (NEO= RM: 7.24, IC 95%=1.71-30.53; ESR= RM: 4.82, IC 95%=1.41-16.50. En el modelo de regresión para ESC, las personas con tabaquismo intenso tuvieron una posibilidad 0.83 veces mayor de fallecer por ESC, y el RA de esta variable para las ESC en la población general fue 45%. (RM=1.83; IC 95% = 1.1-2.8 pObjective. To study the mortality attributable to tobacco and alcohol consumption. Material and Methods. Deaths occurring in 1998, abstracted from the mortality statistics registry in the Coyoacan District of Mexico City, were classified by cause as: Cardiovascular Diseases, Respiratory Diseases, and Neoplasias. Relatives of the deceased were interviewed to answer a questionnaire on tobacco smoking and alcohol drinking. Results. Smoking during the last ten years of life was significantly associated with cardiovascular disease in men aged 70 years or older (OR 2.06, 95% CI 1.18-3.58. Persistent smoking in the last year of life was significantly associated with deaths from neoplasias and respiratory diseases in women aged 70 years or older (OR: 7.24, 95

  7. Estudio bibliométrico de la revista Nutrición Hospitalaria en el periodo 2001 a 2005: Parte I, análisis de la producción científica Bibliometric study of the journal Nutrición Hospitalaria for the period 2001-2005: Part 1, analysis of the scientific production

    OpenAIRE

    V. T. Casterá; J. Sanz-Valero; V. Juan-Quilis; C. Wanden-Berghe; J. M. Culebras; A. García de Lorenzo y Mateos

    2008-01-01

    Objetivo: Evaluar la actividad científica y la producción de información de la revista Nutrición Hospitalaria, en el periodo 2001 a 2005, mediante el análisis bibliométrico. Método: Estudio descriptivo transversal, de los resultados obtenidos del análisis de los artículos publicados en la revista Nutrición Hospitalaria. Los datos se obtuvieron mediante la consulta, a través de la Red, de la versión electrónica. En aquellos casos que se aprecio una ruptura del enlace, y por tanto la imposibili...

  8. Estudio bibliométrico de la revista Nutrición Hospitalaria en el periodo 2001 a 2005: parte 2, análisis de consumo; las referencias bibliográficas Bibliometric study of the journal Nutrición Hospitalaria for the period 2001-2005: part 2, consumption analysis; the bibliographic references

    OpenAIRE

    V. T. Castera; J. Sanz Valero; V. Juan-Quilis; C. Wanden-Berghe; J. M. Culebras; A. García de Lorenzo y Mateos

    2008-01-01

    Objetivo: Describir y evaluar el consumo de información consultada y citada en los artículos publicados en la revista Nutrición Hospitalaria en el periodo 2001 a 2005, mediante el análisis bibliométrico. Método: Estudio descriptivo transversal, de los resultados obtenidos del análisis de los listados de las referencias bibliográficas de los artículos publicados en Nutrición Hospitalaria. Se estudio las revistas más citadas, el índice de firmas, la tipología documental referida, el idioma de p...

  9. Involvement of oxidative stress in the regulation of NPY/CART-mediated appetite control in amphetamine-treated rats.

    Science.gov (United States)

    Hsieh, Yih-Shou; Chen, Pei-Ni; Yu, Ching-Han; Chen, Chia-Hui; Tsai, Tsung-Ta; Kuo, Dong-Yih

    2015-05-01

    Amphetamine (AMPH) treatment can suppress appetite and increase oxidative stress in the brain. AMPH-induced appetite suppression is associated with the regulation of neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART) in the hypothalamus. The present study explored whether antioxidants, including glutathione S-transferase (GST) and glutathione peroxidase (GP), were involved in this NPY/CART-mediated appetite control. Rats were treated daily with AMPH for four days. Changes in food intake and expression levels of hypothalamic NPY, CART, GST, and GP were examined and compared. Results showed that, in AMPH-treated rats, (1) food intake and NPY expression decreased, while CART, GST, and GP expression increased; (2) NPY knockdown in the brain enhanced the decrease in NPY and the increases in CART, GST, and GP expression; and (3) central inhibition of reactive oxygen species production decreased GST and GP and modulated AMPH anorexia and the expression levels of NPY and CART. The present results suggest that oxidative stress in the brain participates in regulating NPY/CART-mediated appetite control in AMPH-treated rats. These results may advance the knowledge regarding the molecular mechanism of AMPH-evoked or NPY/CART-mediated appetite suppression.

  10. Inhibitory modulation of CART peptides in accumbal neuron through decreasing interaction of CaMKIIα with dopamine D3 receptors.

    Science.gov (United States)

    Cai, Zhenyu; Zhang, Dalei; Ying, Ying; Yan, Min; Yang, Jianhua; Xu, Fangyun; Oh, Kiwan; Hu, Zhenzhen

    2014-04-04

    Previous studies in rats have shown that microinjections of cocaine- and amphetamine-regulated transcript (CART) peptide into the nucleus accumbens (NAc; the area of the brain that mediates drug reward and reinforcement) attenuate the locomotor effects of psychostimulants. CART peptide has also been shown to induce decreased intracellular concentrations of calcium (Ca(2+)) in primary cultures of hippocampus neurons. The purpose of this study was to characterize the interaction of Ca(2+)/calmodulin-dependent kinases (CaMKIIα) with dopamine D3 (D3) receptors (R) in primary cultures of accumbal neurons. This interaction is involved in inhibitory modulation of CART peptides. In vitro, CART (55-102) peptide (0.1, 0.5 or 1μM) was found to dose-dependently inhibit K(+) depolarization-elicited Ca(2+) influx and CaMKIIα phosphorylation in accumbal neurons. Moreover, CART peptides were also found to block cocaine (1μM)-induced Ca(2+) influx, CaMKIIα phosphorylation, CaMKIIα-D3R interaction, and CREB phosphorylation. In vivo, repeated microinjections of CART (55-102) peptide (2μg/1μl/side) into the NAc over a 5-day period had no effect on behavioral activity but blocked cocaine-induced locomotor activity. These results indicate that D3R function in accumbal neurons is a target of CART (55-102) peptide and suggest that CART peptide by dephosphorylating limbic D3Rs may have potential as a treatment for cocaine abuse.

  11. CONTROL OF THE DOUBLE INVERTED PENDULUM ON A CART USING THE NATURAL MOTION

    Directory of Open Access Journals (Sweden)

    Zdenek Neusser

    2013-12-01

    Full Text Available This paper deals with controlling the swing-up motion of the double pendulum on a cart using a novel control. The system control is based on finding a feasible trajectory connecting the equilibrium positions from which the eigenfrequencies of the system are determined. Then the system is controlled during the motion between the equilibrium positions by the special harmonic excitation at the system resonances. Around the two equilibrium positions, the trajectory is stabilized by the nonlinear quadratic regulator NQR (also known as SDRE – the State Dependent Riccati Equation. These together form the control between the equilibrium positions demonstrated on the double pendulum on a cart.

  12. New developments of the CARTE thermochemical code: Calculation of detonation properties of high explosives

    Science.gov (United States)

    Dubois, Vincent; Desbiens, Nicolas; Auroux, Eric

    2010-07-01

    We present the improvements of the CARTE thermochemical code which provides thermodynamic properties and chemical compositions of CHON systems over a large range of temperature and pressure with a very small computational cost. The detonation products are split in one or two fluid phase (s), treated with the MCRSR equation of state (EOS), and one condensed phase of carbon, modeled with a multiphase EOS which evolves with the chemical composition of the explosives. We have developed a new optimization procedure to obtain an accurate multicomponents EOS. We show here that the results of CARTE code are in good agreement with the specific data of molecular systems and measured detonation properties for several explosives.

  13. A combined atmospheric radiative transfer (CART) model and its applications for cirrus clouds simulations

    Science.gov (United States)

    Wei, Heli; Cao, Ya'nan; Chen, Xiuhong

    2012-11-01

    A fast atmospheric radiative transfer model called Combined Atmospheric Radiative Transfer model (CART) has been developed to rapidly calculate atmospheric transmittance and background radiance in the wavenumber range from 1 to 25000 cm-1 with spectral resolution of 1 cm-1. The spectral radiative properties of cirrus clouds at various effective sizes, optical thicknesses, and altitudes from visible to infrared wavelength region are simulated using the CART. The analyses show that the properties of cirrus clouds might be retrieved from the satellite-base spectral characteristics of cirrus clouds based on these simulations.

  14. Tratamiento de los defectos del cartílago articular en la rodilla

    OpenAIRE

    Reverté Vinaixa, María Mercedes

    2015-01-01

    Las lesiones condrales y osteocondrales en la rodilla aparecen en gente joven, activa y con gran expectativa de vida. Estás suponen un gran problema, puesto que este una vez destruido, ya no se repara. Debido a la escasa capacidad intrínseca de curación del cartílago, sus lesiones tienden a causar morbilidad en forma de dolor articular y disfunción. Existen diferentes técnicas quirúrgicas que mejoran la sintomatología y la historia natural de las lesiones condrales. Las lesiones del cartílago...

  15. Swing-up Menggunakan Energy Contol Method dan Stabilisasi Menggunakan Fuzzy-LQR pada Pendulum Cart System

    Directory of Open Access Journals (Sweden)

    Agus Lesmana

    2014-03-01

    Full Text Available Pendulum Cart System adalah suatu plant yang terdiri dari batang pendulum yang menggantung dan bersumbu pada kedua sisi kereta yang dapat bergerak pada suatu lintasan dengan sumbu vertikal. Pendulum Cart System merupakan salah satu sistem nonlinear yang sering digunakan untuk pengujian berbagai metode kontrol. Makalah ini membahas desain sistem kontrol swing-up dengan menggunakan energy control method. Setelah melakukan swing-up,  Pendulum Cart System distabilkan pada posisi 0 radian dengan menggunakan Fuzzy Linear Quadratic Regulator (LQR. Model nonlinear Pendulum Cart System direpresentasikan dalam model fuzzy Takagi-Sugeno untuk beberapa titik kerja, kemudian kontroler state feedback disusun dengan konsep Parallel Distributed Compensation (PDC menggunakan Linear Quadratic Regulator (LQR. Hasil simulasi serta implementasi menunjukkan bahwa Pendulum Cart System mampu melakukan swing-up dan stabilisasi walaupun diberikan gangguan pada saat stabilisasi.

  16. Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysis.

    Science.gov (United States)

    Jaworski, Jason N; Kimmel, Heather L; Mitrano, Darlene A; Tallarida, Ronald J; Kuhar, Michael J

    2007-04-01

    CART (cocaine- and amphetamine-regulated transcript) peptides appear to be mediators or modulators of psychostimulant drugs. An interesting result in the nucleus accumbens has been that injection of CART peptide has no effect by itself on locomotor activity, but it reduces the locomotor activity induced by cocaine or amphetamine. However, in the ventral tegmental area (VTA), injections of CART peptide have been shown to increase locomotor activity, although to a lesser degree [Kimmel, H.L., Gong, W., Vechia, S.D., Hunter, R.G., Kuhar, M.J., 2000. Intra-ventral tegmental area injection of rat cocaine and amphetamine-regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place preference. J. Pharmacol. Exp. Ther. 294, 784-792]. This study was carried out to clarify the interaction of intra-VTA CART 55-102 and systemic cocaine on locomotor activity. The CART-cocaine interaction has been examined using the rigorous isobolographic approach. This type of analysis permits an assessment of additivity, subadditivity, or synergism of two substances. By measuring locomotor activity and using a range of doses of CART peptide and cocaine, both alone and together, with different dosing strategies, clear evidence of subadditivity was found. CART reduced the locomotor activating effects of systemic cocaine, especially at higher doses of CART. These results imply that intra-VTA CART is not simply acting in the same manner as cocaine, and is likely to oppose the action of cocaine. This has implications for the physiological significance of CART-DA (dopamine) interactions and for medications development.

  17. Causas y tendencia de la mortalidad en una prisión española (1994-2009

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    Julio García-Guerrero

    2011-01-01

    Full Text Available Fundamento, El conocimiento de las causas de mortalidad puede ser una herramienta valiosa para procurar mejores cuidados de salud a las personas encarceladas. El objetivo del trabajo es describir la mortalidad y su tendencia en nuestro centro. Método, Estudio descriptivo de los fallecimientos ocurridos entre el 01/01/1994 y 31/12/2009. Se compararon mediante el test exacto de Fisher dos periodos de 8 años para valorar cambios en las causas de mortalidad. Previa estandarización indirecta de tasas, comparamos la mortalidad de nuestro centro con la del resto de las prisiones españolas. Mediante un modelo de regresión lineal establecimos la tendencia de las tasas de mortalidad. Resultados, Hubo 59 defunciones, 58 en hombres, con una mediana de edad de 34,9 años (28,7- 40,4. El 64,4% eran VIH+. Desde 1994 hasta 2001 la principal causa de mortalidad fue la infección VIH (48,6% y la segunda los eventos cardiovasculares (10,8%, mientras que entre 2002 y 2009 los eventos cardiovasculares causaron un 31,8% y la infección VIH un 22,7% (p=0,026. Las tasas crudas de mortalidad anual tuvieron tendencia descendente a razón de 0,485 muertes internos/año (IC 95%, 0,864 a -0,107. Estandarizando tasas corresponderían 42 muertes esperadas en todo el período, con una Razón de Mortalidad Estandarizada de 1,407 (IC 95%, 1,071 a 1,816. Conclusiones, La principal causa de mortalidad fue la enfermedad no-VIH, fundamentalmente por eventos cardiovasculares. La tendencia de la tasa de mortalidad fue descendente, aunque observamos un 40,7% más de defunciones de las que cabría esperar.

  18. Protective ileostomy: complications and mortality associated with its closure Ileostomías de protección: complicaciones y mortalidad asociadas a su cierre

    Directory of Open Access Journals (Sweden)

    Mónica Mengual-Ballester

    2012-07-01

    a cierre de ileostomías derivativas. Método: estudio retrospectivo de los pacientes sometidos a cierre de ileostomías en nuestro hospital, en un periodo comprendido entre 2006-2010. En total son 89 pacientes; 56 hombres (63% y 33 mujeres (37%, con una edad media de 55 (38-71 años. La indicación más frecuente para llevar a cabo la ileostomía fue la protección de una anastomosis rectal baja, en un total de 81 pacientes (91%. Se analiza el tiempo de espera hasta el cierre del estoma, el tipo y frecuencia de las complicaciones, la estancia hospitalaria y la mortalidad. Resultados: el tiempo medio de espera entre la elaboración de la ileostomía y su cierre fue de 8 (1-25 meses. Cuarenta y un pacientes (45,9% desarrollaron algún tipo de complicación, 3 de los cuales (3,37% fueron reintervenidos y uno fue éxitus (1,12%. Las complicaciones más importantes fueron: obstrucción intestinal (32,6%, diarrea (6%, infección de la herida quirúrgica (6%, fístula enterocutánea (4,5%, rectorragia (3,4%, y dehiscencia anastomótica (1,12%. La estancia media de los pacientes fue de 7,54 (2-23 días. Conclusiones: la realización de ostomías de protección en las anastomosis rectales bajas ha demostrado ser la única medida preventiva eficaz para disminuir la morbi-mortalidad de las dehiscencias de las mismas. Sin embargo su cierre no debe considerarse un procedimiento menor, sino una intervención con posibles e importantes complicaciones.

  19. Determinantes económicos y sociales de la mortalidad en América Latina

    Directory of Open Access Journals (Sweden)

    Hugo Behm

    2011-01-01

    Full Text Available Este artículo de Hugo Behm, escrito en 1979, realiza un análisis de los determinantes de la mortalidad en América Latina. Fue presentado, originalmente, en la reunión de Naciones Unidas/Organización Mundial de la Salud sobre "Determinantes socioeconómicos de la mortalidad y sus consecuencias" realizada en la Ciudad de México, entre el 19 y el 25 de junio de 1979, y publicado en la Revista Centroamericana de Ciencias de la Salud, No. 12, en 1979. Su reedición en la sección Textos Fundacionales apunta a honrar la memoria del autor y a recuperar un texto pionero en señalar cómo los diferenciales de mortalidad existentes entre países, al interior de los mismos y entre regiones, así como los diferenciales urbano-rural, se explican a partir de desigualdades sociales y económicas que son estructurales y actúan generando "excedentes" de mortalidad por etnia, por grupos de edades y por clases sociales.

  20. Mortalidade por sífilis nas regiões brasileiras, 1980-1995

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    Lima Bruno Gil de Carvalho

    2002-01-01

    Full Text Available Introdução: A sífilis tem diminuído sua prevalência após o advento da antibioticoterapia. No Brasil, é objetivo do Ministério da Saúde a erradicação, daí recomendar-se seu rastreamento mediante testes não-treponêmicos e o tratamento mesmo na impossibilidade de confirmar o diagnóstico. O pré-natal é um momento importante, principalmente para o combate às formas congênitas. Objetivo: Estudar a evolução da mortalidade por sífilis congênita e não-congênita nas regiões brasileiras de 1980 a 1995. Metodologia: O número de óbitos foi conseguido a partir do Datasus. Foram calculados coeficientes de mortalidade por lues para cada macrorregião brasileira. Resultados: Houve uma tendência comum de queda dos coeficientes de mortalidade de 1980 a 1995, embora as regiões Nordeste e Norte tenham apresentado taxas ascendentes no primeiro qüinqüênio. A mortalidade pelas formas não-congênitas, estando em declínio, oscilou entre valores muito baixos. Sífilis congênita apresentou coeficientes mais elevados, entre 1,33 e 8,87/100.000. A região Nordeste apresentou elevação do coeficiente de 120% de 1980 a 1990, com queda discreta (11,5% até 1995. Discussão: Os esforços no sentido de diminuir a prevalência de sífilis no Brasil parecem ter resultado em avanços, já que os coeficientes de mortalidade tenderam ao decréscimo. Entretanto, as baixas taxas de mortalidade são um indicador não apenas da freqüência de sífilis, mas da sua letalidade, bem menor atualmente. Conclusões: Chama a atenção a persistência de níveis elevados, até ascendentes, de mortalidade por lues congênita, provavelmente pelas deficiências existentes na assistência perinatal, que ocorre de forma desigual no território nacional.

  1. Preditores de injúria renal aguda e de mortalidade em uma Unidade de Terapia Intensiva

    Directory of Open Access Journals (Sweden)

    Luis Alberto Batista Peres

    2015-03-01

    Full Text Available Introdução e Objetivos: Comparar características clínicas e evolução dos pacientes com e sem injúria renal aguda (IRA, avaliar a incidência, mortalidade da IRA e fatores de risco de IRA e de óbito em pacientes em uma Unidade de Terapia Intensiva (UTI. Métodos: Estudo retrospectivo que analisou 152 pacientes em uma única UTI. Avaliamos a idade, o sexo, o motivo do internamento, fatores de risco para IRA, dados laboratoriais, a necessidade de terapia renal substitutiva e a mortalidade. Acute Physiology and Chronic Health Evaluation (APACHE II, Sequential Organ Failure Assessment (SOFA e RIFLE foram registrados no dia de admissão na UTI. Determinamos a incidência da IRA, mortalidade e os preditores independentes de IRA e de óbito utilizando o modelo de regressão logística. Resultados: A idade média foi de 57,1 ± 20 anos e 60,1% eram masculinos. IRA não dialítica ocorreu em 81 pacientes (53,2% e a IRA dialítica ocorreu em 19 pacientes (12,4%. A mortalidade global foi de 35,9%, enquanto que a taxa de mortalidade nos pacientes com IRA não dialítica foi de 43,2% e a dos com IRA dialítica de 84,2%. Na análise multivariada, a ventilação mecânica invasiva, a creatinina e a ureia elevadas na admissão foram fatores de risco independentes para IRA, enquanto que diagnóstico clínico, uso de ventilação mecânica invasiva, ureia e lactato aumentados e hipernatremia foram fatores de risco independentes para mortalidade na UTI. Conclusão: A incidência e a mortalidade de IRA na UTI foram elevadas neste estudo, apesar dos avanços que vêm surgindo no seu manejo.

  2. As causas externas no Brasil no ano 2000: comparando a mortalidade e a morbidade

    Directory of Open Access Journals (Sweden)

    Vilma Pinheiro Gawryszewski

    2004-08-01

    Full Text Available Desde o início da década de 80, as causas externas representam a segunda causa de morte no Brasil. Também determinam crescente demanda aos serviços de saúde. O objetivo do presente trabalho é analisar a morbi-mortalidade por causas externas no Brasil. O material do estudo é composto pelas 118.367 mortes e 652.249 internações hospitalares por causas externas ocorridas no Brasil no ano 2000. Os dados são provenientes do Sistema de Informações de Mortalidade e Sistema de Informações Hospitalares. Entre os resultados destaca-se que o coeficiente de mortalidade por causas externas foi 69,7/100 mil (119,0/100 mil para os homens e 21,8/100 mil para as mulheres. Os homicídios lideraram as causas de morte (38,3% do total, com coeficiente alto, 26,7/100 mil e as quedas lideram as internações (42,8% do total. Os traumas e lesões relacionados ao transporte terrestre são importantes tanto na morbidade quanto na mortalidade. As fraturas representaram 42,6% das hospitalizações, mais freqüentes em membros superiores e inferiores. Aponta-se que os programas de prevenção devem ter impacto tanto na mortalidade quanto na morbidade, com destaque para os homicídios, transporte e quedas.

  3. Fecundidad y mortalidad en Córdoba (1991 en regiones con diferente desarrollo

    Directory of Open Access Journals (Sweden)

    Arias Toledo, Bárbara

    2005-01-01

    Full Text Available Con los datos del Censo de 1991 se estimó la fecundidad, mediante métodos directos, con la información sobre niños nacidos vivos en el último año de mujeres en edad fértil. La mortalidad fue estimada indirectamente, con la información de hijos nacidos vivos y sobrevivientes de aquellas mujeres. Estos indicadores fueron calculados para subdivisiones tipificadas en trabajos previos de acuerdo a un Índice de Desarrollo Socio-Demográfico en niveles Bajo, Medio-Bajo, Medio, Medio Alto y Alto. Los resultados indican que los niveles de mayor desarrollo socio demográfico, en particular el nivel Medio Alto, tienen menor fecundidad, mientras que la mayor coincide con un menor nivel de desarrollo. Respecto a la mortalidad, son los niveles de menor desarrollo los que poseen las más altas probabilidades de muerte, mayor mortalidad infantil y menor esperanza de vida. Por el contrario, la menor mortalidad es característica del nivel Medio Alto. Se concluye que el que ha seguido la más fuerte tendencia de disminución de fecundidad y mortalidad es el Medio Alto, que reúne los departamentos que tienen mayor desarrollo en agricultura, ganadería y turismo, y menor concentración urbana que la ciudad capital (nivel Alto. Por otra parte, con los mayores indicadores aparecen los niveles Medio Bajo y Bajo, con economía en retroceso y escaso acceso a centros sanitarios de media y alta complejidad.

  4. Robust Takagi-Sugeno Fuzzy Dynamic Regulator for Trajectory Tracking of a Pendulum-Cart System

    Directory of Open Access Journals (Sweden)

    Miguel A. Llama

    2015-01-01

    Full Text Available Starting from a nonlinear model for a pendulum-cart system, on which viscous friction is considered, a Takagi-Sugeno (T-S fuzzy augmented model (TSFAM as well as a TSFAM with uncertainty (TSFAMwU is proposed. Since the design of a T-S fuzzy controller is based on the T-S fuzzy model of the nonlinear system, then, to address the trajectory tracking problem of the pendulum-cart system, three T-S fuzzy controllers are proposed via parallel distributed compensation: (1 a T-S fuzzy servo controller (TSFSC designed from the TSFAM; (2 a robust TSFSC (RTSFSC designed from the TSFAMwU; and (3 a robust T-S fuzzy dynamic regulator (RTSFDR designed from the RTSFSC with the addition of a T-S fuzzy observer, which estimates cart and pendulum velocities. Both TSFAM and TSFAMwU are comprised of two fuzzy rules and designed via local approximation in fuzzy partition spaces technique. Feedback gains for the three fuzzy controllers are obtained via linear matrix inequalities approach. A swing-up controller is developed to swing the pendulum up from its pendant position to its upright position. Real-time experiments validate the effectiveness of the proposed schemes, keeping the pendulum in its upright position while the cart follows a reference signal, standing out the RTSFDR.

  5. 蛋鸡下丘脑 CART mRNA序列测定及分析

    Institute of Scientific and Technical Information of China (English)

    于雪静; 庞钰莹; 贺俊平; 李鹏飞; 姜晓龙; 吕丽华

    2013-01-01

      可卡因-苯丙胺调节转录肽(Cocaine-and Amphetamine-Reg ul ated Transcript, CART)对动物繁殖功能有重要调控作用。本试验选用蛋鸡作为研究对象,根据 NCBI 上已登录的各物种的 CART mRNA 序列设计特异性引物,用 RT-PCR 方法从蛋鸡下丘脑内扩增出 CART 部分 CDS 序列并利用 DNAMAN 软件进行分析。结果表明CART 基因在蛋鸡下丘脑内有表达,并获得了230 bp 的序列,为进一步研究蛋鸡产蛋性能奠定基础。

  6. Enterobacteriaceae and related organisms isolated from nest run cart shelves in commercial shell egg processing facilities

    Science.gov (United States)

    Enterobacteriaceae, including Salmonella may be recovered from foods and processing facilities. High levels of Enterobacteriaceae in the processing plant environment can be an indication of inadequate sanitation. This experiment was designed to determine if nest run egg carts serve as reservoirs ...

  7. CART DIAGNOSIS OF WATERSHED IMPAIRMENT IN THE MID-ATLANTIC REGION

    Science.gov (United States)

    Many factors ( stressors ) can lead to increased concentrations of nutrients and sediments, and these factors change across watersheds. Classification and Regression Tree (CART) is a statistical approach that can be used to "diagnose" which factors are important stressors on a pe...

  8. What Works Clearinghouse Quick Review: "A Model for Success: CART's Linked Learning Program Increases College Enrollment"

    Science.gov (United States)

    What Works Clearinghouse, 2012

    2012-01-01

    The study, "A Model for Success: CART's Linked Learning Program Increases College Enrollment" examined whether students who enrolled in courses at a high school that combined academics and technical education had higher college enrollment rates than students who did not. The research described in this report does not meet What Works…

  9. Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

    Science.gov (United States)

    Sotillo, Elena; Barrett, David M.; Black, Kathryn L; Bagashev, Asen; Oldridge, Derek; Wu, Glendon; Sussman, Robyn; Lanauze, Claudia; Ruella, Marco; Gazzara, Matthew R.; Martinez, Nicole M.; Harrington, Colleen T.; Chung, Elaine Y.; Perazzelli, Jessica; Hofmann, Ted J.; Maude, Shannon L.; Raman, Pichai; Barrera, Alejandro; Gill, Saar; Lacey, Simon F.; Melenhorst, Jan J.; Allman, David; Jacoby, Elad; Fry, Terry; Mackall, Crystal; Barash, Yoseph; Lynch, Kristen W.; Maris, John M.; Grupp, Stephan A.; Thomas-Tikhonenko, Andrei

    2015-01-01

    The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can be targeted with chimeric antigen receptor–armed T cells (CART-19), but relapses with epitope loss occur in 10% to 20% of pediatric responders. We detected hemizygous deletions spanning the CD19 locus and de novo frameshift and missense mutations in exon 2 of CD19 in some relapse samples. However, we also discovered alternatively spliced CD19 mRNA species, including one lacking exon 2. Pull-down/siRNA experiments identified SRSF3 as a splicing factor involved in exon 2 retention, and its levels were lower in relapsed B-ALL. Using genome editing, we demonstrated that exon 2 skipping bypasses exon 2 mutations in B-ALL cells and allows expression of the N-terminally truncated CD19 variant, which fails to trigger killing by CART-19 but partly rescues defects associated with CD19 loss. Thus, this mechanism of resistance is based on a combination of deleterious mutations and ensuing selection for alternatively spliced RNA isoforms. Significance CART-19 yield 70% response rates in patients with B-ALL, but also produce escape variants. We discovered that the underlying mechanism is the selection for preexisting alternatively spliced CD19 isoforms with the compromised CART-19 epitope. This mechanism suggests a possibility of targeting alternative CD19 ectodomains, which could improve survival of patients with B-cell neoplasms. PMID:26516065

  10. A bedside food cart as an alternate food service for acute and palliative oncological patients.

    Science.gov (United States)

    Pietersma, Patti; Follett-Bick, Sandra; Wilkinson, Brenda; Guebert, Nancy; Fisher, Kim; Pereira, Jose

    2003-09-01

    Patients with advanced cancer experience various problems with eating, and their meals should be tailored to meet their specific needs. Two methods of food service were compared in a shared acute oncology/palliative care unit; an electrical food cart allowing patients to select their food types and portions at the bedside, and a traditional food tray delivery service that relied on meals being prepared in a centralized kitchen and then delivered by tray. Over a 10-day period, lunch meals were delivered by food cart and supper meals via food trays. Twenty-seven out of 32 patients participated in the trial. Patients significantly preferred the food cart to the trays with respect to the timing and appeal of the meal, appropriateness of food types and food portions and the variety of the food choices. A food cart as used in this trial provides a more flexible and appropriate method of food delivery to in-patients in the oncology and palliative unit. Further studies should examine whether this translates to improved caloric intake and quality of life parameters.

  11. KLASIFIKASI KARAKTERISTIK KECELAKAAN LALU LINTAS DI KOTA DENPASAR DENGAN PENDEKATAN CLASSIFICATION AND REGRESSION TREES (CART

    Directory of Open Access Journals (Sweden)

    I GEDE AGUS JIWADIANA

    2015-11-01

    Full Text Available The aim of this research is to determine the classification characteristics of traffic accidents in Denpasar city in January-July 2014 by using Classification And Regression Trees (CART. Then, for determine the explanatory variables into the main classifier of CART. The result showed that optimum CART generate three terminal node. First terminal node, there are 12 people were classified as heavy traffic accident characteritics with single accident, and second terminal nodes, there are 68 people were classified as minor traffic accident characteristics by type of traffic accident front-rear, front-front, front-side, pedestrians, side-side and location of traffic accident in district road and sub-district road. For third terminal node, there are 291 people were classified as medium traffic accident characteristics by type of traffic accident front-rear, front-front, front-side, pedestrians, side-side and location of traffic accident in municipality road and explanatory variables into the main splitter to make of CART is type of traffic accident with maximum homogeneity measure of 0.03252.

  12. Demonstration of a Filter Cart for NOx Removal from Ground Support Equipment.

    Science.gov (United States)

    2007-11-02

    emissions. The filter cart was designed to control emissions of NOx, particulate, and unburned hydrocarbons ( UHCs ) from mobile diesel generators. It uses a...rows of activated carbon (AC) filters to adsorb NOx and UHCs . A separate stand-alone system is used to desorb and destroy the contaminants adsorbed

  13. EDITORIAL MORTALIDAD EVITABLE DE MANUSCRITOS CIENTÍFICOS

    Directory of Open Access Journals (Sweden)

    Mauricio Palacios

    2010-06-01

    convencional de la revista3.El abandono de los autores a su obra en alguna de las fases editoriales no debería suceder. Elaborar un manuscrito para someterlo a publicación, requiere mucho esfuerzo y tiempo adicionales; sin embargo, aceptar o discutir las observaciones de los pares evaluadores y enviar una versión corregida, necesita cierta dedicación, proporcionalmente menor, si se compara con el primer esfuerzo. Los procesos editoriales contienen un gran componente de crítica y este concepto no debería ofender a los autores, pues tampoco hay límite de versiones cuando lo que se pretende es presentar el trabajo de la mejor manera posible. Una actitud útil para esta fase de la edición es delegar desde el principio un líder responsable del seguimiento del artículo; lo natural es considerar al autor que redactó el manuscrito para mantener el estilo y que éste coordine con sus colaboradores los cambios que se deben hacer. Es bueno que el autor principal (si hay más de uno sepa que siempre puede contar con el cuerpo editorial para sus consultas o discutir cualquier aspecto en la elaboración de una versión final.Las deficiencias para redactar son parte del curso natural de aprender a escribir. La educación superior se enfoca en que el estudiante comprenda un texto, no que lo componga y la formación en este aspecto para los investigadores del área de la salud es casi nula. Escribir requiere un mentor, ojalá con bastante práctica. Por este motivo aconsejo a los interesados que consulten la obra de Cassany4, un guía experto en construir escritura.Por último, existen virtudes que evitan la mortalidad editorial. Reconocerse como escritor imperfecto promueve la solicitud de examinar los textos entre pares, e incluso entre los profanos en el tema; si entienden lo que se ha escrito, sin duda hay mejoría. Es bueno recordar que el peor manuscrito es aquel que nunca se escribe y sólo aquellos que no han escrito artículos científicos, son quienes no han tenido alguna

  14. The importance of viral blips and duration of therapy initiated in primary infection in maintaining viral control after stopping cART

    OpenAIRE

    2014-01-01

    Introduction: After achieving undetectable HIV-RNA on cART, on cessation, HIV-RNA rebounds to pre-treatment values for the majority due to the presence of an inaccessible viral reservoir. There is some evidence that cART during primary HIV infection (PHI) limits the reservoir size, optimizing the chance of maintaining viral control off cART. Data are required to predict possible viral controllers for treatment interruption following cART. This analysis aims to investigate the effect of cART d...

  15. The nucleus accumbens 5-HTR₄-CART pathway ties anorexia to hyperactivity.

    Science.gov (United States)

    Jean, A; Laurent, L; Bockaert, J; Charnay, Y; Dusticier, N; Nieoullon, A; Barrot, M; Neve, R; Compan, V

    2012-12-11

    In mental diseases, the brain does not systematically adjust motor activity to feeding. Probably, the most outlined example is the association between hyperactivity and anorexia in Anorexia nervosa. The neural underpinnings of this 'paradox', however, are poorly elucidated. Although anorexia and hyperactivity prevail over self-preservation, both symptoms rarely exist independently, suggesting commonalities in neural pathways, most likely in the reward system. We previously discovered an addictive molecular facet of anorexia, involving production, in the nucleus accumbens (NAc), of the same transcripts stimulated in response to cocaine and amphetamine (CART) upon stimulation of the 5-HT(4) receptors (5-HTR(4)) or MDMA (ecstasy). Here, we tested whether this pathway predisposes not only to anorexia but also to hyperactivity. Following food restriction, mice are expected to overeat. However, selecting hyperactive and addiction-related animal models, we observed that mice lacking 5-HTR(1B) self-imposed food restriction after deprivation and still displayed anorexia and hyperactivity after ecstasy. Decryption of the mechanisms showed a gain-of-function of 5-HTR(4) in the absence of 5-HTR(1B), associated with CART surplus in the NAc and not in other brain areas. NAc-5-HTR(4) overexpression upregulated NAc-CART, provoked anorexia and hyperactivity. NAc-5-HTR(4) knockdown or blockade reduced ecstasy-induced hyperactivity. Finally, NAc-CART knockdown suppressed hyperactivity upon stimulation of the NAc-5-HTR(4). Additionally, inactivating NAc-5-HTR(4) suppressed ecstasy's preference, strengthening the rewarding facet of anorexia. In conclusion, the NAc-5-HTR(4)/CART pathway establishes a 'tight-junction' between anorexia and hyperactivity, suggesting the existence of a primary functional unit susceptible to limit overeating associated with resting following homeostasis rules.

  16. CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion.

    Science.gov (United States)

    Qiu, Bin; Hu, Shengdi; Liu, Libing; Chen, Man; Wang, Lai; Zeng, Xianwei; Zhu, Shigong

    2013-07-12

    Cocaine and amphetamine regulated transcript (CART), a neuropeptide, has shown strong neuroprotective effects against cerebral ischemia and reperfusion (I/R) injury in vivo and in vitro. Here, we report a new effect of CART on ER stress which is induced by cerebral I/R in a rat model of middle cerebral artery occlusion (MCAO) or by oxygen and glucose deprivation (OGD) in cultured cortical neurons, as well as a new functionality of BDNF in the neuroprotection by CART against the ER stress in cerebral I/R. The results showed that CART was effective in reducing the neuronal apoptosis and expression of ER stress markers (GRP78, CHOP and cleaved caspase12), and increasing the BDNF expression in I/R injury rat cortex both in vivo and in vitro. In addition, the effects of CART on ischemia-induced neuronal apoptosis and ER stress were suppressed by tyrosine receptor kinase B (TrkB) IgG, whereas the effects of CART on BDNF transcription, synthesis and secretion were abolished by CREB siRNA. This work suggests that CART is functional in inhibiting the cerebral I/R-induced ER stress and neuronal apoptosis by facilitating the transcription, synthesis and secretion of BDNF in a CREB-dependent way.

  17. Wide-field diffuse amacrine cells in the monkey retina contain immunoreactive Cocaine- and Amphetamine-Regulated Transcript (CART).

    Science.gov (United States)

    Long, Ye; Bordt, Andrea S; Liu, Weiley S; Davis, Elizabeth P; Lee, Stephen J; Tseng, Luke; Chuang, Alice Z; Whitaker, Christopher M; Massey, Stephen C; Sherman, Michael B; Marshak, David W

    2016-10-01

    The goals of this study were to localize the neuropeptide Cocaine- and Amphetamine-Regulated Transcript (CART) in primate retinas and to describe the morphology, neurotransmitter content and synaptic connections of the neurons that contain it. Using in situ hybridization, light and electron microscopic immunolabeling, CART was localized to GABAergic amacrine cells in baboon retinas. The CART-positive cells had thin, varicose dendrites that gradually descended through the inner plexiform layer and ramified extensively in the innermost stratum. They resembled two types of wide-field diffuse amacrine cells that had been described previously in macaque retinas using the Golgi method and also A17, serotonin-accumulating and waterfall cells of other mammals. The CART-positive cells received synapses from rod bipolar cell axons and made synapses onto the axons in a reciprocal configuration. The CART-positive cells also received synapses from other amacrine cells. Some of these were located on their primary dendrites, and the presynaptic cells there included dopaminergic amacrine cells. Although some CART-positive somas were localized in the ganglion cell layer, they did not contain the ganglion cell marker RNA binding protein with multiple splicing (RBPMS). Based on these results and electrophysiological studies in other mammals, the CART-positive amacrine cells would be expected to play a major role in the primary rod pathway of primates, providing feedback inhibition to rod bipolar cells.

  18. Quantitative and qualitative evaluation of CART-containing cells in adrenal glands of male rats with hypertension.

    Science.gov (United States)

    Kasacka, I; Piotrowska, Ż; Knaś, M; Lewandowska, A

    2014-10-01

    Adrenal activity is stimulated and secretion of stress hormones is increased during advanced stages of renovascular hypertension. The literature suggests that the neuropeptide, cocaine and amphetamine regulated transcript (CART), might regulate adrenal secretory function and thus could influence its activity. We assessed potential quantitative and qualitative changes in the cells that contained CART in the adrenal glands of rats with renovascular hypertension. The renal arteries of ten rats were subjected to a clipping procedure, i.e., two-kidney one-clip (2K1C) model of arterial hypertension, and after 6 weeks each rat developed stable hypertension. CART was localized using immunohistochemistry. CART was detected in a large population of cells in the medulla, sparse nerve fibers in the cortex and the capsule of the adrenal gland. The population of CART-positive cells in adrenal glands of two kidney-one clip (2K1C) treated rats was greater and their immunoreactivity was increased compared to controls. Similarly, the length, width, area and diameter of CART-immunoreactive cells were significantly greater in the hypertensive rats than in controls. We demonstrated that renovascular hypertension alters the number and immunoreactivity of CART-containing cells in adrenal glands.

  19. Evaluation of CART peptide level in rat plasma and CSF: Possible role as a biomarker in opioid addiction.

    Science.gov (United States)

    Bakhtazad, Atefeh; Vousooghi, Nasim; Garmabi, Behzad; Zarrindast, Mohammad Reza

    2016-10-01

    It has been shown previously that cocaine- and amphetamine-regulated transcript (CART) peptide has a modulatory role and homeostatic regulatory effect in motivation to and reward of the drugs of abuse specially psychostimulants. Recent data also showed that in addition to psychostimulants, CART is critically involved in the different stages of opioid addiction. Here we have evaluated the fluctuations in the level of CART peptide in plasma and CSF in different phases of opioid addiction to find out whether CART can serve as a suitable marker in opioid addiction studies. Male rats were randomly distributed in groups of control, acute low-dose (10mg/kg) morphine, acute high-dose morphine (80mg/kg), chronic escalating doses of morphine, withdrawal syndrome precipitated by administration of naloxone (1mg/kg), and abstinent after long-term drug-free maintenance of addicted animals. The level of CART peptide in CSF and plasma samples was measured by enzyme immunoassay. CART peptide concentration in the CSF and plasma was significantly elevated in acute high-dose morphine and withdrawal state animals and down-regulated in addicted rats. In abstinent group, CART peptide level was up-regulated in plasma but not in CSF samples. As the observed results are in agreement with data regarding the CART mRNA and protein expression in the brain reward pathway in opioid addiction phases, it may be suggested that evaluation of CART peptide level in CSF or plasma could be a suitable marker which reflects the rises and falls of the peptide concentration in brain in the development of opioid addiction.

  20. Cocaine- and amphetamine-regulated transcript (CART signaling within the paraventricular thalamus modulates cocaine-seeking behaviour.

    Directory of Open Access Journals (Sweden)

    Morgan H James

    Full Text Available BACKGROUND: Cocaine- and amphetamine-regulated transcript (CART has been demonstrated to play a role in regulating the rewarding and reinforcing effects of various drugs of abuse. A recent study demonstrated that i.c.v. administration of CART negatively modulates reinstatement of alcohol seeking, however, the site(s of action remains unclear. We investigated the paraventricular thalamus (PVT as a potential site of relapse-relevant CART signaling, as this region is known to receive dense innervation from CART-containing hypothalamic cells and to project to a number of regions known to be involved in mediating reinstatement, including the nucleus accumbens (NAC, medial prefrontal cortex (mPFC and basolateral amygdala (BLA. METHODOLOGY/PRINCIPAL FINDINGS: Male rats were trained to self-administer cocaine before being extinguished to a set criterion. One day following extinction, animals received intra-PVT infusions of saline, tetrodotoxin (TTX; 2.5 ng, CART (0.625 µg or 2.5 µg or no injection, followed by a cocaine prime (10 mg/kg, i.p.. Animals were then tested under extinction conditions for one hour. Treatment with either TTX or CART resulted in a significant attenuation of drug-seeking behaviour following cocaine-prime, with the 2.5 µg dose of CART having the greatest effect. This effect was specific to the PVT region, as misplaced injections of both TTX and CART resulted in responding that was identical to controls. CONCLUSIONS/SIGNIFICANCE: We show for the first time that CART signaling within the PVT acts to inhibit drug-primed reinstatement of cocaine seeking behaviour, presumably by negatively modulating PVT efferents that are important for drug seeking, including the NAC, mPFC and BLA. In this way, we identify a possible target for future pharmacological interventions designed to suppress drug seeking.

  1. In-hospital mortality and the Glasgow Coma Scale in the first 72 hours after traumatic brain injury Escala de Coma de Glasgow en las primeras 72 horas postrauma encefalocraneano y mortalidad hospitalaria Escala de Coma de Glasgow nas primeiras 72 horas após trauma cranioencefálico e mortalidade hospitalar

    OpenAIRE

    Cristina Helena Costanti Settervall; Regina Marcia Cardoso de Sousa; Silvia Cristina Fürbringer e Silva

    2011-01-01

    This study verifies and compares the performance of three different scores obtained in the Glasgow Coma Scale (GCS) in the first 72 hours post trauma in predicting in-hospital mortality. The studied scores included those obtained after initial care was provided at the hospital, and the worst and best scores obtained in the scale in the first 72 hours post trauma. The scale’s predictive ability was assessed by the Receiver Operator Characteristic (ROC) curve. A total of 277 victims with differ...

  2. Caracterização dos padrões de mortalidade e identificação dos pontos negros de mortalidade da fauna na A21

    OpenAIRE

    Moreira, Dulce Maria da Conceição Malcata dos Reis

    2015-01-01

    A monitorização da mortalidade da fauna nas estradas tem vindo a receber mais atenção no decorrer dos anos sendo uma temática em que ainda existe potencial para investigação assim como de propostas para medidas de mitigação. Em Portugal, os estudos mais desenvolvidos são geralmente realizados por concessionárias como a Infraestruturas de Portugal, a Brisa entre outras. Reconhece-se a importância desta temática devido aos impactes negativos a nível ecológico e ambiental resultantes da ex...

  3. Análisis del impacto de la mortalidad por suicidios en México, 2000-2012

    OpenAIRE

    Claudio Alberto Dávila Cervantes; María del Pilar Ochoa Torres; Irene Casique Rodríguez

    2015-01-01

    El objetivo del presente artículo es analizar la carga de la mortalidad por suicidios en México, a partir del indicador de años de vida perdidos (AVP), entre 2000 y 2012, por sexo, grupos de edad (para menores de 85 años de edad) a nivel nacional y por entidad federativa. Se emplearon estadísticas vitales de mortalidad y estimaciones de población para calcular tasas estandarizadas de mortalidad y los años de vida perdidos por suicidios. Entre 2000 y 2012 se dio un incremento sostenido de la t...

  4. Mortalidad infantil y marginación en la península de Yucatán

    OpenAIRE

    2004-01-01

    Se presentan resultados de un estudio orientado a conocer la distribución territorial de la mortalidad infantil y su relación con algunos indicadores socioeconómicos en la península de Yucatán, en el período 1990-2000. Se estimaron las Tasas de Mortalidad Infantil (TMI) estatales y municipales. Para la caracterización socioeconómica se utilizaron los índices y estratos de marginación del Consejo Nacional de Población. Primero se analizaron cartográficamente los datos de mortalidad infantil y ...

  5. FACTORES DE RIESGO PARA MORTALIDAD CARDIOVASCULAR Y GENERAL EN LOS PACIENTES CON ENFERMEDAD RENAL CRÓNICA TERMINAL

    OpenAIRE

    Pérez Molina, Jorge Lenin

    2012-01-01

    La enfermedad renal crónica (ERC) constituye un problema de salud pública con alta incidencia y prevalencia y amplia gama de complicaciones que conllevan a un aumento en la mortalidad en pacientes con diálisis. La mortalidad por enfermedad cardiovascular (ECV) es hasta 20 veces más frecuente en esta población. Objetivo: Identificar los factores de riesgo para mortalidad cardiovascular y general en los pacientes con enfermedad renal crónica terminal (ERCT) que se encuentren b...

  6. Mortalidad y reclutamiento de árboles en un bosque pluvial tropical de chocó (colombia).

    OpenAIRE

    Quinto Mosquera, Harley; Rengifo Ibargüen, Reimer; Ramos Palacios, Yan Arley

    2011-01-01

    Se calcularon las tasas de mortalidad y reclutamiento de árboles en una parcela permanente de investigación de un bosque pluvial tropical. El estudio se basó en dos mediciones, una realizada en el año 1998 y la otra en el 2005, en las cuales se midió el diámetro (DAP) a todos los árboles con DAP≥10 cm y se censaron los individuos muertos y reclutados. Se determinaron los tipos de mortalidad y se calculó el coeficiente de mortalidad, el coeficiente de reclutamiento exponencial, la biomasa a...

  7. GANANCIA FUNCIONAL Y ESTANCIA HOSPITALARIA EN LA UNIDAD GERIATRICA DE MEDIA ESTANCIA DEL HOSPITAL CENTRAL DE CRUZ ROJA DE MADRID

    Directory of Open Access Journals (Sweden)

    Juan J. Baztán

    2004-01-01

    Full Text Available Fundamento: Las unidades geriátricas de media estancia o convalecencia fueron definidas por el Insalud en 1996 como aquel nivel asistencial geriátrico hospitalario destinado a restablecer aquellas funciones, actividades o secuelas, alteradas como resultado de diferentes procesos previos. El objetivo de este trabajo es evaluar las características de los pacientes asociadas a la ganancia funcional y estancia en las unidades geriátricas de media estancia. Métodos: Se estudió a todos los pacientes ingresados entre mayo de 2000 y diciembre de 2001. Se evaluó la ganancia funcional semanal y global con el Indice de Barthel, la estancia hospitalaria y la eficiencia (IB al alta-IB al ingreso/estancia. Se estableció como umbral de eficacia la mejora en la ganancia semanal > 5 puntos en IB. Resultados: Fueron evaluados 459 pacientes con una edad media de edad de 80,56 (±7,45 ingresados para recuperación funcional de secuelas de ictus (48,4%, patología ortopédica (26,3% e inmovilismo por otras patologías (23,5%. La ganancia funcional total fue de 29,71 (±16,75 puntos en el Indice de Barthel, con una estancia media de 24,93 (±12,94 días y una eficiencia de 1,44 (±1,02. La ganancia funcional semanal estuvo por encima del umbral establecido en las tres primeras semanas, independientemente de la edad y patología motivo de ingreso. En el análisis de regresión multivariante la edad, el ingreso por ictus, el deterioro funcional previo y cognitivo al ingreso, la comorbilidad y demora en el ingreso se asociaron a menor ganancia funcional. El ingreso por ictus y la mejor situación funcional previa y cognitiva al ingreso se asociaron a mayor estancia. Conclusiones: La estancia hospitalaria en unidades geriátricas de media estancia es adecuada, al menos, en las tres primeras semanas. La comparación de los resultados entre unidades debiera ajustarse por edad, patología motivo de ingreso, comorbilidad y situación funcional y cognitiva de los

  8. Mortalidad por cáncer en la persona adulta mayor de Costa Rica

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    Manrique Leal-Mateos

    2005-01-01

    Full Text Available Justificación y objetivo: El análisis de la mortalidad por cáncer en el adulto mayor continúa siendo una herramienta importante para identificar los factores de riesgo asociados. El presente estudio tiene como finalidad analizar la mortalidad por cáncer en las personas adultas mayores del país durante el año 2002. Métodos: Se realizó un estudio descriptivo de corte transversal. La fuente de información utilizada fue la base de datos del CCP-INEC, facilitada por los centros de documentación e información de estas mismas instituciones. Las variables estudiadas fueron: edad, sexo y lugar de residencia de cada persona fallecida. Además, se registró la localización anatómica de los tumores con base en la clasificación internacional de enfermedades (CIE-10. Mediante el ajuste directo de tasas de analizó la mortalidad por provincia. Resultados: Durante el año 2002, se registraron 3 167 muertes por cáncer en el país. De estas, 1 960 (61,8% ocurrieron en personas mayores de 65 años. El 58,2% (n = 1141 afectaron al sexo masculino. El cáncer de próstata presentó la tasa más alta de mortalidad. Al calcular las tasas de mortalidad ajustada para cada provincia, se observó que Cartago presentó la tasa más alta. Discusión: El 61, 8% del total de muertes por cáncer en el país ocurren en la población adulta mayor. Este resultado resulta importante si consideramos el costo que representa para los servicios de salud la atención de este tipo de pacientes. El riesgo de fallecer por cáncer es considerablemente superior después de los 65 años. Por tanto, la disminución de la mortalidad debe realizarse por medio de programas preventivos de menor costo y que se desarrollen en edades tempranas.

  9. EFECTO PROTECTOR DEL APOYO SOCIAL EN LA MORTALIDAD EN POBLACIÓN ANCIANA: UN ESTUDIO LONGITUDINAL

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    Manel Nebot

    2002-01-01

    Full Text Available Fundamentos: El objetivo principal del estudio es analizar la relación entre el apoyo social y la mortalidad en una cohorte de población de 60 años o más, residente en Barcelona y no institucionalizada, observada durante el período de seguimiento de 1996 a 1999, con el objetivo de analizar la relación entre el apoyo social y la mortalidad en las personas que constituyen la cohorte. Métodos: En 1996 se realizó una entrevista telefónica a 755 personas (316 hombres y 439 mujeres que habían sido entrevistadas en la encuesta de salud de Barcelona de 1992, y que en ese año tenían 60 años o más. En el cuestionario se recogían variables socio-demográficas, de morbilidad y estado de salud, de apoyo social y de red social. Se han registrado los fallecimientos ocurridos entre 1996 y 1999. Se ha utilizado la regresión logística para analizar la asociación del apoyo social con la mortalidad. Resultados: El número de defunciones durante este período fue de 55 (5,9% de las mujeres y 9,2% de los hombres. Entre las variables que reflejan el apoyo social para los hombres, únicamente la situación de convivencia mostró en el análisis bivariado una asociación significativa con la mortalidad, que fue superior para los hombres que vivían con otros familiares pero no si vivían con su esposa o compañera (OR=3,7; IC 95% 1,4-9,6. Entre las mujeres, la existencia de apoyo vecinal, el tamaño de la red familiar, el número de contactos con la red comunitaria y la situación de convivencia se asociaron a la mortalidad en el análisis bivariado, aunque en la regresión logística multivariada, únicamente el apoyo vecinal (OR=3,6; IC:1,1-11,1 mantuvo una asociación significativa. Conclusiones: Los resultados muestran una asociación de las variables de apoyo social con la mortalidad. La relación entre las diversas variables de apoyo social, y los posibles mecanismos de prevención deberían ser abordados en futuros estudios.

  10. Tablas de mortalidad, jubilación e invalidez, Costa Rica 2000-2005

    Directory of Open Access Journals (Sweden)

    Rosero Bixby, Luis

    2008-07-01

    Full Text Available Se estimaron las tablas de vida de Costa Rica del período 2000-2005, detalladas por edades simples y hasta los 115 años de edad. Además, se comparó el patrón de mortalidad general con la de los derecho habientes a pensión dentro de los regímenes contributivos. También, se proyectó una tabla de vida para 2025-2030 y un modelo para estimar las probabilidades de muerte por edades simples, sexo y año calendario dentro del período 2006-2050. La comparación tabla de vida 2000-05 con la de cinco años atrás muestra el progreso en la esperanza de vida. Al nacer, la esperanza de vida fue de 78,2 años para ambos sexos (75,9 para los hombres y 80,6 las mujeres. Costa Rica continúa ocupando el segundo lugar de América como el país de mayor esperanza de vida al nacer, solo superado por Canadá. La esperanza de vida a los 65 años (edad aproximada de jubilación, aumentó medio año para los varones y casi un año para las mujeres; pasando de 16,9 a 17,5 años en hombres y de 19,1 a 19,9 en mujeres. La comparación de los patrones de mortalidad de la población general con las poblaciones con derecho a pensión, mostró que la mortalidad de los derecho habientes no difiere significativamente de la mortalidad de la población total, en cambio para los jubilados e inválidos si se observaron diferencias. La tabla de mortalidad proyectada estima las condiciones probables de mortalidad que vivirán quienes se pensionen en 2007-2011. La proyección supuso un progreso cada vez más lento en la esperanza de vida. Estas tablas de vida se prepararon para la Superintendencia de Pensiones, de manera que sirvan como referencia en cálculos actuariales de seguros de vida y pensiones vitalicias.

  11. Tablas de mortalidad, jubilación e invalidez, Costa Rica 2000-2005

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    Luis Rosero Bixby

    2008-01-01

    Full Text Available Se estimaron las tablas de vida de Costa Rica del período 2000-2005, detalladas por edades simples y hasta los 115 años de edad. Además, se comparó el patrón de mortalidad general con la de los derecho habientes a pensión dentro de los regímenes contributivos. También, se proyectó una tabla de vida para 2025-2030 y un modelo para estimar las probabilidades de muerte por edades simples, sexo y año calendario dentro del período 2006-2050. La comparación tabla de vida 2000-05 con la de cinco años atrás muestra el progreso en la esperanza de vida. Al nacer, la esperanza de vida fue de 78,2 años para ambos sexos (75,9 para los hombres y 80,6 las mujeres. Costa Rica continúa ocupando el segundo lugar de América como el país de mayor esperanza de vida al nacer, solo superado por Canadá. La esperanza de vida a los 65 años (edad aproximada de jubilación, aumentó medio año para los varones y casi un año para las mujeres; pasando de 16,9 a 17,5 años en hombres y de 19,1 a 19,9 en mujeres. La comparación de los patrones de mortalidad de la población general con las poblaciones con derecho a pensión, mostró que la mortalidad de los derecho habientes no difiere significativamente de la mortalidad de la población total, en cambio para los jubilados e inválidos si se observaron diferencias. La tabla de mortalidad proyectada estima las condiciones probables de mortalidad que vivirán quienes se pensionen en 2007-2011. La proyección supuso un progreso cada vez más lento en la esperanza de vida. Estas tablas de vida se prepararon para la Superintendencia de Pensiones, de manera que sirvan como referencia en cálculos actuariales de seguros de vida y pensiones vitalicias.

  12. Comparison of single and boosted protease inhibitor versus nonnucleoside reverse transcriptase inhibitor-containing cART regimens in antiretroviral-naïve patients starting cART after January 1, 2000

    DEFF Research Database (Denmark)

    Mocroft, A; Horban, A; Clumeck, N;

    2006-01-01

    BACKGROUND: Few published studies have considered both the short- and long-term virologic or immunologic response to combination antiretroviral therapy (cART) and the impact of different cART strategies. PURPOSE: To compare time to initial virologic (200/mm3 cell...... increase) response in antiretroviral-naïve patients starting either a single protease inhibitor (PI; n = 183), a ritonavir-boosted PI regimen (n = 197), or a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based cART regimen (n = 447) after January 1, 2000, and the odds of lack of virologic...... or immunologic response at 3 years after starting cART. METHOD: Cox proportional hazards models and logistic regression. RESULTS: After adjustment, compared to patients taking an NNRTI-regimen, patients taking a single-PI regimen were significantly less likely to achieve a viral load (VL)

  13. The impact of altitude on hospitalization and hospital mortality from pandemic 2009 influenza A (H1N1 virus pneumonia in Mexico El impacto de la altitud en las tasas de hospitalización y mortalidad por el virus de la influenza A (H1N1 pandémico en México

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    Rogelio Pérez-Padilla

    2013-02-01

    Full Text Available OBJECTIVE: To determine the effect of altitude of residence on influenza A (H1N1. MATERIALS AND METHODS: We analyzed 207 135 officially notified of influenza-like illness (ILI cases, 23 048 hospitalizations and 573 deaths during the first months of the novel pandemic influenza A H1N1 virus, to examine if residents of high altitude had more frequently these adverse outcomes. RESULTS: Adjusted rates for hospitalization and hospital mortality rates increased with altitude, probably due to hypoxemia.OBJETIVO: Determinar el efecto de la altitud del lugar de residencia sobre la epidemia de influenza A (H1N1. MATERIAL Y MÉTODOS: Se analizaron 207 135 casos notificados a la Secretaría de Salud, 23 048 hospitalizaciones y 573 muertes por enfermedad similar a la influenza (ILI, por sus siglas en inglés durante los primeros meses de la pandemia del nuevo virus de la influenza A H1N1 durante 2009, para examinar si los residentes de zonas más altas presentaron tasas más altas de hospitalización y muerte. RESULTADOS: Las tasas ajustadas de hospitalización y mortalidad hospitalaria se incrementaron con la altitud probablemente por la presencia de hipoxemia.

  14. Control borroso para la valoración del impacto ambiental generado por contaminantes emergentes en aguas residuales hospitalarias

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    Leadina Sánchez Barboza

    2015-06-01

    Full Text Available La valoración de impactos ambientales está sujeta a imprecisión, vaguedad y subjetividad. Estas características son extensivas al impacto generado por la presencia de contaminantes emergentes -fármacos- en aguas residuales hospitalarias, por lo que este trabajo propone valorar el impacto de dichos contaminantes mediante un sistema de inferencia borrosa, utilizando el toolbox fuzzy logic de MATLAB®, aplicando el sistema experto Mamdani. Los conjuntos borrosos de entrada se establecieron a partir de las concentraciones de los fármacos mediante variables lingüísticas definidas por medio de funciones de pertenencia trapezoidales, y el conjunto borroso de salida comprende la magnitud del impacto definida a través de una función de pertenencia triangular. Posteriormente, se obtuvo una valoración (en escala de 0 a 100 para concentraciones de fármacos máximas y promedios presentes en el agua residual, y por último, con estos valores se determina la magnitud del impacto ambiental a través del sistema de inferencia borrosa diseñado. El tratamiento borroso es útil para valorar los impactos ambientales en aguas residuales de contaminantes emergentes como los compuestos farmacéuticos.

  15. Tendencias de mortalidad por cánceres atribuibles al tabaco en México

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    Tovar-Guzmán Víctor José

    2002-01-01

    Full Text Available Objetivo. Describir la tendencia de la mortalidad por cáncer atribuible al consumo de tabaco, particularmente neoplasias del pulmón, en México, durante el periodo 1980-1997. Material y métodos. Se hizo un análisis de tendencias de mortalidad para cada tipo de cáncer asociado con el tabaco, según la Clasificación Internacional de Enfermedades. Las tasas cruda y ajustada de mortalidad fueron estimadas en términos de edad, género, causa básica de la muerte y año, entre 1980 y 1997. Se estimó la razón de género y proporción relativa para los casos que estaban en el grupo de edad entre 35 y 64 años y para toda la población estudiada. Como denominador se utilizaron las proyecciones por edad calculadas por el Consejo Nacional de Población (1970-2010. Resultados. La razón de género para las tasas de mortalidad por cáncer de laringe, esófago, cavidad oral y faringe fue de 2.10:1.00 (hombre: mujer. La razón de género para el cáncer de laringe es enorme: 4.21: 1.00, probablemente debida a la mayor prevalencia de hombres fumadores de tabaco. La proporción relativa estimada, usando la mortalidad total debida a tumores malignos, entre 1980 y 1997 fue la siguiente: cáncer de pulmón 12.31%, laringe 1.71%, esófago 1.55% y cavidad oral/faringe 1.49%. El antecedente de tabaquismo tiene correlación con la tendencia de la tasa de mortalidad por cáncer del pulmón (Beta: 0.910, IC 95%: 1.097-1.797; R² 0.827. Para los grupos sociales mas pobres, por entidad federativa, la correlación está invertida (Beta: -0.510, IC 95%: -0.170, -0.039, R²: 0.260. Conclusiones. En México, la mejoría en el diagnóstico, la transición demográfica y el incremento del consumo de tabaco son, probablemente, los principales factores a los que se atribuye la tasa de mortalidad por cáncer. No obstante, otras variables asociadas con el estilo de vida, como urbanización, actividad física, ingesta de carotenoides y otros componentes dietéticos y t

  16. Correcao de informacoes vitais: estimacao da mortalidade infantil, Brasil, 2000-2009

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    Paulo Germano de Frias

    2013-12-01

    Full Text Available OBJETIVO : Propor método simplificado para corrigir informações vitais e estimar o coeficiente de mortalidade infantil no Brasil. MÉTODOS : A correção dos dados vitais dos sistemas de informação sobre mortalidade e nascidos vivos foi obtida por meio de fatores de correção, estimados com base em eventos não informados ao Ministério da Saúde e captados por pesquisa de busca ativa. O método simplificado de correção das informações vitais, de 2000-2009 para o Brasil e unidades da federação, estabelece o nível de adequação das informações de óbitos e nascidos vivos, pelo cálculo do coeficiente geral de mortalidade padronizado por idade e da razão entre os nascidos vivos, informados e esperados, respectivamente, em cada município brasileiro. A partir da aplicação dos fatores de correção ao número de óbitos e nascidos vivos, informados em cada município, as estatísticas vitais foram corrigidas, possibilitando estimar o coeficiente de mortalidade infantil. RESULTADOS : Os maiores fatores de correção foram referentes aos óbitos infantis que atingiram valores maiores do que 7 para municípios com grande precariedade de informações de mortalidade. Os fatores de correção apresentaram gradiente decrescente à medida que melhoraram os indicadores de adequação das informações vitais para óbitos e nascidos vivos. As informações vitais corrigidas pelo método simplificado por unidade da federação, em 2008, foram similares às obtidas na pesquisa de busca ativa. A taxa de natalidade e o coeficiente de mortalidade infantil decresceram em todas as regiões brasileiras, no período. A taxa de decréscimo anual foi de 6,0% no Nordeste, a maior do Brasil (4,7%. CONCLUSÕES : A busca ativa de óbitos e nascimentos possibilitou calcular fatores de correção por nível de adequação das informações de mortalidade e de nascidos vivos. O método simplificado proposto permitiu corrigir as informações vitais por

  17. Mortalidad por cáncer en los mineros del mercurio Cancer mortality in mercury miners

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    Montserrat García Gómez

    2007-06-01

    Full Text Available Objetivos: Analizar la mortalidad por cáncer en una cohorte de mineros del mercurio. Métodos: Estudiamos la mortalidad por cáncer de 3.998 mineros expuestos a mercurio de Minas de Almadén y Arrayanes, S.A. El período de seguimiento comprendió desde 1895 hasta 1994. Se determinó el estado vital y la causa básica de defunción. Se calcularon las razones de mortalidad estandarizadas (RME según la edad, el sexo y el período de calendario. Las muertes esperadas se obtuvieron de las tasas específicas españolas. Resultados: Se determinó el estado vital del 92% de los trabajadores: 1.786 estaban vivos en 1994 (49%, 1.535 habían muerto (42% y de 327 no pudo conocerse el estado vital (8%. La mortalidad por cáncer fue significativamente menor de la esperada (RME de 0,72; intervalo de confianza del 95%, 0,63-0,82, y se encontró el déficit principalmente en los cánceres de colon y vejiga. Se encontró un pequeño exceso en la mortalidad por cáncer de hígado, para el que se registraron 20 muertes, mientras se esperaban 17. La mortalidad por cáncer de pulmón y del sistema nervioso central fue prácticamente igual a la esperada; la mortalidad por cáncer de riñón fue menor de la esperada. Se observó una tendencia positiva en la mortalidad por todos los tipos de cáncer con la duración de la exposición. Conclusiones: Esta investigación aporta evidencias adicionales de la ausencia de un aumento sustancial del riesgo de cáncer en los trabajadores expuestos al mercurio inorgánico.Objectives: To analyze cancer mortality in a cohort of mercury miners. Methods: Cancer mortality in 3,998 workers exposed to mercury in Minas de Almadén y Arrayanes S.A. was studied. The follow-up period was from 1895 to 1994. Vital status and the basic cause of death, in the case of fatalities, were determined. Standardized mortality ratios (SMR by age, sex and calendar period were calculated. Expected deaths were obtained from age, sex and calendar period

  18. O que os dados de mortalidade do Censo de 2010 podem nos dizer?

    OpenAIRE

    2012-01-01

    O Censo brasileiro de 2010 incluiu, em seu questionário, a pergunta sobre óbitos ocorridos no domicílio nos últimos 12 meses. Anteriormente, uma questão similar havia sido incluída na amostra do Censo de 1980, mas sendo pouco utilizada. O objetivo do artigo é fazer uma avaliação da qualidade da informação de mortalidade do Censo, em especial sobre a estrutura etária da mortalidade. Em relação à cobertura da enumeração dos óbitos, esta saltou de 40%, no Censo de 1980, para 80%, no de 2010. Os ...

  19. Mortalidad infantil en Uruguay: un análisis de supervivencia

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    Jewell R. Todd

    2010-12-01

    Full Text Available A partir de todos los nacimientos ocurridos en el Uruguay entre 2002 y 2003 y las defunciones ocurridas en el primer año de vida, se estima la tasa de mortalidad infantil a través de modelos probit y hazard. Debido a que las muertes se concentran en los primeros días y semanas de vida, el modelo hazard es preferible al probit, encontrándose que la estimación probit sobreestima los efectos de las covariables. Los resultados muestran que las variables más importantes son la edad y la educación de la madre, los cuidados prenatales y los denominados predictores de la mortalidad (bajo peso al nacer, semanas de gestación y APGAR.

  20. MORTALIDAD YCOSTES ASOCIADOS A LA DEMORA DEL TRATAMIENTO QUIRÚRGICO POR FRACTURA DE CADERA

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    Iñigo Etxebarria-Foronda

    2013-01-01

    Full Text Available Fundamentos: La intervención quirúrgica en las fracturas de cadera suele demorarse varios días. Nuestro trabajo tiene dos objetivos. Estudiar la estancia preoperatoria de los pacientes ingresados por fractura de cade- ra en los hospitales vascos durante el año 2010 y medir su posible asocia- ción con la mortalidad intrahospitalaria, y estimar el coste económico que supone la estancia preoperatoria. Métodos. Se realizó un estudio observacional analizando los siguien- tes datos del Conjunto Mínimo Básico de Datos (CMBD: hospital, edad, sexo, estancia preoperatoria, estado al alta, diagnósticos asociados y pro- cedimiento quirúrgico. Además, se estudió el índice de comorbilidad de Charlson y se calculó el coste unitario de la estancia pre y postoperatoria mediante modelos de regresión múltiple. Resultados. Se analizó una muestra de 1.856 intervenciones. La es- tancia preoperatoria fue de 2,7 días y la postoperatoria de 9,7 días. El cos- te medio por ingreso fue de 12.552,12 euros. El coste medio de la estan- cia preoperatoria fue de 1295,5 euros. La mortalidad fue del 5%. Conclusiones. La estancia preoperatoria no es un factor estadística- mente asociado con la mortalidad, aunque aumenta significativamente el coste total. No encontramos una asociación entre la demora quirúrgica y la mortalidad, aunque sí tiene una clara influencia en el coste total del proceso. La reducción del tiempo prequirúrgico permite ahorrar costes.

  1. Mortalidade de idosos em município do Sudeste brasileiro de 2006 a 2011

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    Rodolpho Telarolli Júnior

    2014-03-01

    Full Text Available O objetivo foi descrever a mortalidade entre idosos em Araraquara (SP, no período de 2006 a 2011. Estudo epidemiológico descritivo, tendo como fontes de dados o Sistema de Informações sobre Mortalidade e a Fundação Sistema Estadual de Análise de Dados. Foi calculada razão entre coeficientes de mortalidade por ponto (R e por intervalo de 95% de confiança (IC95%. Observou-se mais de 60% dos idosos com nível baixo de escolaridade, sendo que 76% faleceram em hospitais. Entre 2006 e 2008, as diferenças foram estatisticamente significantes entre homens e mulheres, predominando as doenças circulatórias com R = 1,41 (IC95%:1,24-1,58, respiratórias com R = 1,49 (IC95%:1,22-1,76 e neoplasias com R = 1,79 (IC95%: 1,40-2,18. Entre 2009 e 2011, obteve-se, para as causas circulatórias R = 1,18 (IC95%:1,03-1,33, sendo significativas as diferenças para as respiratórias com R = 1,33 (IC95%:1,11-1,55 e câncer sendo R = 1,94 (IC95%:1,53-2,35. O diabetes mellitus e as causas externas apareceram, respectivamente, como quarta e quinta causas de mortes mais frequentes na população idosa. O padrão de mortalidade encontrado ressalta a importância de ações voltadas à redução das principais causas de morte, como o incremento da cobertura da vacina contra a influenza e o controle da hipertensão arterial e do diabetes mellitus.

  2. Mortalidad materna en Cali ¿una década sin cambios?

    Directory of Open Access Journals (Sweden)

    Ana Salazar Aristizábal

    2009-10-01

    Full Text Available Se hizo un estudio retrospectivo de 353 registros de muertes maternas durante 10 años (1985-1994 en Cali. Los objetivos fueron: identificar algunos factores sociodemográficos y obstétricos de la mortalidad materna evitable en Cali; medir su nivel de subregistro y estimar la concordancia entre la causa básica de muerte registrada en el certificado de defunción y la causa básica asignada por el Comité de Mortalidad Materna de la Secretaría de Salud Municipal de Cali. Los hallazgos indicaron que 96.2% de las muertes eran evitables de acuerdo con los criterios establecidos por el Comité de Mortalidad Materna. Hubo un subregistro de 17.8%, con mayor proporción en las instituciones privadas. Las causas maternas directas presentaron concordancia moderada (K = 0.68 y el menor grado de concordancia se obtuvo en las causas indirectas (K = 0.29. Con la presente investigación se demostró que la búsqueda exhaustiva de muertes maternas en mujeres de 15 a 49 años permitió encontrar casos nuevos que no se captaron en los certificados de defunción; pero, a pesar de esta búsqueda, el nivel de subregistro es importante. Otro aspecto de gran importancia y de enorme impacto consiste en que la mortalidad materna en Cali en los últimos 10 años, no ha tenido cambios significantes, a pesar de los esfuerzos en acciones y en alta inversión para atender a la salud de las mujeres. Conocer la magnitud real de este problema permitirá tomar medidas y definir intervenciones apropiadas para su reducción.

  3. Variaciones regionales de la mortalidad por homicidios en Jalisco, México

    Directory of Open Access Journals (Sweden)

    María Guadalupe Vega-López

    Full Text Available El presente estudio busca describir las variaciones regionales de la mortalidad por homicidios en el estado de Jalisco, México, en 1989-1991, 1994-1996 y 1999-2000, analizando a su vez el comportamiento de la tasa de homicidios según género y estratos de bienestar socioeconómico. A partir de la información sobre mortalidad generada por el Instituto Nacional de Estadística, Geografía y Informática, se calcularon tasas ajustadas por edad y género e índices de sobremortalidad masculina. Además, se calcularon razones de tasa y su intervalo de confianza (95%. Los resultados reflejan que la tasa de homicidios presenta una tendencia decreciente en los años 90; que existe un patrón regional de la mortalidad por homicidios, observándose las tasas más altas en regiones periféricas del estado consideradas entre las más pobres; que los municipios ubicados en el estrato de bienestar más bajo presentan un exceso de mortalidad por homicidios estadísticamente significativo, y que hay una evidente sobremortalidad masculina por esta causa. Aspectos como los antes descritos implican tareas y desafíos para la salud pública y para los organismos encargados de preservar la ley y el orden, entre ellos la necesidad de implementar políticas intersectoriales diferenciadas, que tomen en consideración las particularidades que rodean al homicidio y al crimen violento en Jalisco.

  4. Tendencias de mortalidad por traumatismos y envenenamientos en adolescentes: México, 1979-1997

    Directory of Open Access Journals (Sweden)

    Celis Alfredo

    2003-01-01

    Full Text Available OBJETIVO: Describir las causas externas de la mortalidad por traumatismos y envenenamientos, así como la tendencia que estas causas han mostrado entre adolescentes en México, de 1979 a 1997. MATERIAL Y MÉTODOS: Para la realización de este estudio descriptivo de la mortalidad se utilizaron las bases de datos de mortalidad registrada en México de 1979 a 1997. Los datos son recabados, codificados y capturados por el Instituto Nacional de Estadística, Geografía e Informática, y se obtuvieron a través del Instituto Nacional de Salud Pública. Los datos fueron tabulados durante el último semestre de 2000, en Jalisco, en la Unidad de Investigación Epidemiológica y en Servicios de Salud del Adolescente del Instituto Mexicano del Seguro Social. RESULTADOS: Los traumatismos y envenenamientos ocuparon el primer lugar en la mortalidad del grupo adolescente (tasa de 13.35/100 000 con una tendencia descendente de -41.4% durante el periodo 1979-1997, no obstante el incremento de homicidios y suicidios (9.5% y 104.0% respectivamente. Los mecanismos más frecuentes fueron los vehículos de tráfico de motor, las armas de fuego, las intoxicaciones, las sofocaciones y las asfixias por inmersión. CONCLUSIONES: Los traumatismos y envenenamientos que experimenta la población de países en desarrollo muestran frecuencias diferentes a lo registrado en los más desarrollados, haciendo necesario el estudio de los mismos para implantar las medidas preventivas acordes con las condiciones socioculturales y ambientales de cada entorno.

  5. The inhibition of cocaine-induced locomotor activity by CART 55-102 is lost after repeated cocaine administration.

    Science.gov (United States)

    Job, Martin O; Shen, Li L; Kuhar, Michael J

    2013-08-29

    CART peptide is known for having an inhibitory effect on cocaine- and dopamine-mediated actions after acute administration of cocaine and dopamine. In this regard, it is postulated to be a homeostatic, regulatory factor on dopaminergic activity in the nucleus accumbens (NAc). However, there is no data on the effect of CART peptide after chronic administration of cocaine, and this study addresses this. It was found that CART peptide blunted cocaine-induced locomotion (LMA) after acute administration of cocaine, as expected, but it did not affect cocaine-mediated LMA after chronic administration of cocaine. The loss of CART peptide's inhibitory effect did not return for up to 9 weeks after stopping the repeated cocaine administration. It may not be surprising that homeostatic regulatory mechanisms in the NAc are lost after repeated cocaine administration, and that this may be a mechanism in the development of addiction.

  6. Selection of Pedaling Load and Design of Electric-Cart Control System with Continuously Adjustable Pedal Load

    Science.gov (United States)

    She, Jin-Hua; Ishii, Shota; Yokota, Sho; Sakuma, Yuji; Ohyama, Yasuhiro

    A previously developed electric cart was improved by installing a knob that allows the driver to continuously vary the pedal load between the strenuous and assisted modes. This paper explains how the pedal load is determined and a design method for the cart control system. First, the largest pedal load is determined from the standpoint of ergonomics on the basis of the rating of perceived exertion and the Karvonen formula with a special focus on the motor function of the elderly. Then, a gain-scheduling cart control system for any pedal load in the allowed range is described, and a stability condition is derived using dynamic parallel distributed compensation. Experimental results demonstrate the validity of the cart control system.

  7. Efficacy and toxicity management of CAR-T cell immunotherapy: A matter of responsiveness control or tumor-specificity?

    DEFF Research Database (Denmark)

    Alonso-Camino, Vanesa; Harwood, Seandean Lykke; Alvarez-Méndez, Ana M;

    2016-01-01

    Chimeric antigen receptor (CAR)-expressing T cells have demonstrated potent clinical efficacy in patients with hematological malignancies. However, the use of CAR-T cells targeting solid tumor-associated antigens (TAAs) has been limited by organ toxicities related to activation of T cell effector...... functions through the CAR. Most existing CARs recognize TAAs, which are also found in normal tissues. CAR-T cell-mediated destruction of normal tissues constitutes a major roadblock to CAR-T cell therapy, and must be avoided or mitigated. There is a broad range of strategies for modulating antigen...... responsiveness of CAR-T cells, with varying degrees of complexity. Some of them might ameliorate the acute and chronic toxicities associated with current CAR constructs. However, further embellishments to CAR therapy may complicate clinical implementation and possibly create new immunogenicity issues...

  8. Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse.

    Science.gov (United States)

    Kenderian, Saad S; Porter, David L; Gill, Saar

    2017-02-01

    Hematopoietic cell transplantation (HCT) remains an important and potentially curative option for most hematologic malignancies. As a form of immunotherapy, allogeneic HCT (allo-HCT) offers the potential for durable remissions but is limited by transplantation- related morbidity and mortality owing to organ toxicity, infection, and graft-versus-host disease. The recent positive outcomes of chimeric antigen receptor T (CART) cell therapy in B cell malignancies may herald a paradigm shift in the management of these disorders and perhaps other hematologic malignancies as well. Clinical trials are now needed to address the relative roles of CART cells and HCT in the context of transplantation-eligible patients. In this review, we summarize the state of the art of the development of CART cell therapy for leukemia, lymphoma, and myeloma and discuss our perspective of how CART cell therapy can be applied in the context of HCT.

  9. Valor preditivo da frequência cardíaca em repouso do teste ergométrico na mortalidade

    Directory of Open Access Journals (Sweden)

    Jaqueline Eilert Fagundes

    2010-12-01

    Full Text Available FUNDAMENTO: A frequência cardíaca em repouso (cuja média está entre 60 e 80 bpm é uma das mais simples variáveis cardiovasculares e tem sido considerada como um preditor de mortalidade cardiovascular e geral. OBJETIVO: Avaliar o valor preditivo da frequência cardíaca em repouso (FCR, antes do teste ergométrico (TE, na mortalidade cardiovascular (CV e geral. MÉTODOS: Estudo de caso-controle, que utilizou informações contidas nos bancos de dados do laboratório de ergometria de um hospital especializado em cardiologia e os registros de óbitos da Secretaria da Saúde em uma cidade do sul do Brasil, de janeiro de 1995 a junho de 2007. Foram analisados 7.055 pacientes, sendo 1.645 (23,3% do grupo caso (óbitos e 5.410 (76,7% do grupo controle (vivos. Foi calculado o ponto de corte da FCR para mortalidade, através da curva ROC e realizada a análise multivariada para as variáveis selecionadas. Os desfechos foram mortalidade CV e geral. RESULTADOS: A incidência de mortalidade CV foi de 674 casos (9,5%; a FCR > 78 bpm foi o ponto de corte. Após ajustado para as variáveis selecionadas, o odds ratio (OR para FCR > 78 bpm foi de 3,5 (IC 95% = 2,9 - 4,2 para mortalidade CV e 3,6 (IC 95% = 3,2 - 4,0 para mortalidade geral. CONCLUSÃO: A FCR > 78 bpm é um preditor independente de mortalidade cardiovascular e geral.

  10. Problemas del sistema de salud en estados de México con alta incidencia de mortalidad materna

    OpenAIRE

    Mariel Rouvier; Miguel Ángel González-Block; Paola Sesia; Víctor Becerril-Montekio

    2013-01-01

    Objetivo. Identificar y priorizar problemas de los sistemas estatales de salud que limitan la eficacia de las intervenciones para prevenir la mortalidad materna. Material y métodos. Se realizó un mapeo conceptual de los problemas prioritarios percibidos por comunidades de práctica (Cop) en estados con alta incidencia de mortalidad materna. Posteriormente, las Cop revisaron la literatura médica para contrastar los problemas identificados. Resultados. Los problemas priorizados por las Cop se en...

  11. La calidad de los datos de mortalidad del Censo 2010 de Argentina

    Directory of Open Access Journals (Sweden)

    Nicolás Sacco

    2016-07-01

    Full Text Available Objetivo: evaluar las variables disponibles en el censo de población de 2010 para Argentina en lo que a mortalidad refiere. Métodos: Con base en métodos indirectos de estimación demográfica se ofrece una lectura de la calidad de estas estadísticas en comparación con censos previos y estadísticas vitales. Resultados: La comparación de las tasas de mortalidad infantil y adulta con las tasas calculadas a partir de los nacimientos y las defunciones permite dilucidar, en principio, que estos datos no revelan problemas serios de calidad o cobertura y que el nivel (y la tendencia indicado por las fuentes es ampliamente compatible. Discusión: a pesar de que los resultados parecen mostrar coherencia, la posibilidad de detectar y cuantificar los errores se mantiene como un punto ciego del artículo hasta tanto no se publique la totalidad de la información necesaria para realizar un examen cabal, dado el universo limitado de publicaciones por parte del Instituto Nacional de Estadística y Censos. Conclusiones: las estimaciones de población en cuanto a mortalidad son consistentes con los datos del censo previo de 2001 y con las series de nacimientos y muertes del período intercensal a nivel total del país.

  12. Mortalidad por accidentes de tránsito en Bayamo, Cuba 2011

    Directory of Open Access Journals (Sweden)

    Arlines Piña-Tornés

    Full Text Available Con el objetivo de describir la mortalidad por accidentes de tránsito en Bayamo, Cuba, en el año 2011 se realizó una revisión de los pacientes lesionados y fallecidos a causa de accidentes de tránsito, registrados en Hospital Carlos M. de Céspedes. Se atendieron en emergencias 1365 lesionados, predominando el grupo etario de 25 a 44 años con 372 pacientes (27,3%, y el sexo masculino con 1071 (78,5%. Fallecieron 46 personas, en su mayoría del mismo grupo de edad y de sexo masculino. Los traumatismos múltiples (52,6% y cráneofaciales (34,2% fueron las localizaciones predominantes. Se destacaron los atropellos por vehículo de motor con mortalidad del 26,3%. En conclusión, la mortalidad por accidentes de tránsito predomina en adultos jóvenes masculinos; cuyas consecuencias fatales son debido a traumatismos múltiples por atropellos.

  13. Mortalidade por tumores de cérebro no Brasil, 1980-1998

    Directory of Open Access Journals (Sweden)

    Monteiro Gina Torres Rego

    2003-01-01

    Full Text Available Os tumores cerebrais são raros, mas sua incidência e mortalidade vêm aumentando ao longo das últimas décadas em vários países, inclusive no Brasil, particularmente entre idosos. O presente artigo descreve o perfil da mortalidade desses tumores no país, analisando a distribuição de suas taxas segundo sexo, idade, topografia e natureza tumoral entre 1980 e 1998. As taxas de mortalidade por esta neoplasia, ajustadas por idade pela população mundial, cresceram de 2,24/100 mil para 3,35/100 mil, correspondendo a um aumento de 50%. Estas foram mais elevadas na infância que na adolescência, aumentando posteriormente com a idade e alcançando níveis altos nos mais idosos, sendo o crescimento médio nos maiores de 70 anos de 6% ao ano ao longo da série estudada. São analisadas as taxas de tumores do encéfalo e das meninges cerebrais para o país e para capitais selecionadas. A constatação do aumento dessas taxas demanda a elaboração de estudos com vistas a elucidar o papel de novas tecnologias diagnósticas, assim como de potenciais fatores de risco ambientais.

  14. Reflexões sobre a mensuração da mortalidade materna

    Directory of Open Access Journals (Sweden)

    Laurenti Ruy

    2000-01-01

    Full Text Available A mortalidade materna é um ótimo indicador da saúde da mulher e, de certa forma, da saúde geral da população. Há grande disparidade entre as taxas (ou razões referentes a diferentes áreas, sendo seu valor bastante elevado nos países subdesenvolvidos ou em desenvolvimento, como é o caso do Brasil. Numerosos países adotaram programas visando a redução da mortalidade materna, necessitando, então, conhecer as respectivas taxas (ou razões para avaliar e monitorar esses programas. Ocorrem, por várias motivos, dificuldades em conhecer a verdadeira magnitude dessas mensurações. O trabalho apresenta métodos propostos para estimar a mortalidade materna, destacando-se a necessidade de ver com certa reserva os métodos indiretos, preferindo-se sempre, como no caso do Brasil, o aperfeiçoamento do registro civil, fonte legítima dos dados de nascimentos e de mortes.

  15. Mortalidad por accidentes de tránsito en Bayamo, Cuba 2011

    Directory of Open Access Journals (Sweden)

    Arlines Piña-Tornés

    2014-10-01

    Full Text Available Con el objetivo de describir la mortalidad por accidentes de tránsito en Bayamo, Cuba, en el año 2011 se realizó una revisión de los pacientes lesionados y fallecidos a causa de accidentes de tránsito, registrados en Hospital Carlos M. de Céspedes. Se atendieron en emergencias 1365 lesionados, predominando el grupo etario de 25 a 44 años con 372 pacientes (27,3%, y el sexo masculino con 1071 (78,5%. Fallecieron 46 personas, en su mayoría del mismo grupo de edad y de sexo masculino. Los traumatismos múltiples (52,6% y cráneofaciales (34,2% fueron las localizaciones predominantes. Se destacaron los atropellos por vehículo de motor con mortalidad del 26,3%. En conclusión, la mortalidad por accidentes de tránsito predomina en adultos jóvenes masculinos; cuyas consecuencias fatales son debido a traumatismos múltiples por atropellos.

  16. Assessing the HIV Care Continuum in Latin America: progress in clinical retention, cART use and viral suppression

    Science.gov (United States)

    Rebeiro, Peter F; Cesar, Carina; Shepherd, Bryan E; De Boni, Raquel B; Cortés, Claudia P; Rodriguez, Fernanda; Belaunzarán-Zamudio, Pablo; Pape, Jean W; Padgett, Denis; Hoces, Daniel; McGowan, Catherine C; Cahn, Pedro

    2016-01-01

    Introduction We assessed trends in HIV Care Continuum outcomes associated with delayed disease progression and reduced transmission within a large Latin American cohort over a decade: clinical retention, combination antiretroviral therapy (cART) use and viral suppression (VS). Methods Adults from Caribbean, Central and South America network for HIV epidemiology clinical cohorts in seven countries contributed data between 2003 and 2012. Retention was defined as two or more HIV care visits annually, >90 days apart. cART was defined as prescription of three or more antiretroviral agents annually. VS was defined as HIV-1 RNA <200 copies/mL at last measurement annually. cART and VS denominators were subjects with at least one visit annually. Multivariable modified Poisson regression was used to assess temporal trends and examine associations between age, sex, HIV transmission mode, cohort, calendar year and time in care. Results Among 18,799 individuals in retention analyses, 14,380 in cART analyses and 13,330 in VS analyses, differences existed between those meeting indicator definitions versus those not by most characteristics. Retention, cART and VS significantly improved from 2003 to 2012 (63 to 77%, 74 to 91% and 53 to 82%, respectively; p<0.05, each). Female sex (risk ratio (RR)=0.97 vs. males) and injection drug use as HIV transmission mode (RR=0.83 vs. male sexual contact with males (MSM)) were significantly associated with lower retention, but unrelated with cART or VS. MSM (RR=0.96) significantly decreased the probability of cART compared with heterosexual transmission. Conclusions HIV Care Continuum outcomes improved over time in Latin America, though disparities for vulnerable groups remain. Efforts must be made to increase retention, cART and VS, while engaging in additional research to sustain progress in these settings. PMID:27065108

  17. Assessing the HIV Care Continuum in Latin America: progress in clinical retention, cART use and viral suppression

    Directory of Open Access Journals (Sweden)

    Peter F Rebeiro

    2016-04-01

    Full Text Available Introduction: We assessed trends in HIV Care Continuum outcomes associated with delayed disease progression and reduced transmission within a large Latin American cohort over a decade: clinical retention, combination antiretroviral therapy (cART use and viral suppression (VS. Methods: Adults from Caribbean, Central and South America network for HIV epidemiology clinical cohorts in seven countries contributed data between 2003 and 2012. Retention was defined as two or more HIV care visits annually, >90 days apart. cART was defined as prescription of three or more antiretroviral agents annually. VS was defined as HIV-1 RNA <200 copies/mL at last measurement annually. cART and VS denominators were subjects with at least one visit annually. Multivariable modified Poisson regression was used to assess temporal trends and examine associations between age, sex, HIV transmission mode, cohort, calendar year and time in care. Results: Among 18,799 individuals in retention analyses, 14,380 in cART analyses and 13,330 in VS analyses, differences existed between those meeting indicator definitions versus those not by most characteristics. Retention, cART and VS significantly improved from 2003 to 2012 (63 to 77%, 74 to 91% and 53 to 82%, respectively; p<0.05, each. Female sex (risk ratio (RR=0.97 vs. males and injection drug use as HIV transmission mode (RR=0.83 vs. male sexual contact with males (MSM were significantly associated with lower retention, but unrelated with cART or VS. MSM (RR=0.96 significantly decreased the probability of cART compared with heterosexual transmission. Conclusions: HIV Care Continuum outcomes improved over time in Latin America, though disparities for vulnerable groups remain. Efforts must be made to increase retention, cART and VS, while engaging in additional research to sustain progress in these settings.

  18. Region- and sex-specific changes in CART mRNA in rat hypothalamic nuclei induced by forced swim stress.

    Science.gov (United States)

    Balkan, Burcu; Gozen, Oguz; Koylu, Ersin O; Keser, Aysegul; Kuhar, Michael J; Pogun, Sakire

    2012-10-15

    Cocaine and amphetamine regulated transcript (CART) mRNA and peptides are highly expressed in the paraventricular (PVN), dorsomedial (DMH) and arcuate (ARC) nuclei of the hypothalamus. It has been suggested that these nuclei regulate the hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system activity, and feeding behavior. Our previous studies showed that forced swim stress augmented CART peptide expression significantly in whole hypothalamus of male rats. In another study, forced swim stress increased the number of CART-immunoreactive cells in female PVN, whereas no effect was observed in male PVN or in the ARC nucleus of either sex. In the present study, we evaluated the effect of forced swim stress on CART mRNA expression in PVN, DMH and ARC nuclei in both male and female rats. Twelve male (stressed and controls, n=6 each) and 12 female (stressed and controls, n=6 each) Sprague-Dawley rats were used. Control animals were only handled, whereas forced swim stress procedure was applied to the stressed groups. Brains were dissected and brain sections containing PVN, DMH and ARC nuclei were prepared. CART mRNA levels were determined by in situ hybridization. In male rats, forced swim stress upregulated CART mRNA expression in DMH and downregulated it in the ARC. In female rats, forced swim stress increased CART mRNA expression in PVN and DMH, whereas a decrease was observed in the ARC nucleus. Our results show that forced swim stress elicits region- and sex-specific changes in CART mRNA expression in rat hypothalamus that may help in explaining some of the effects of stress.

  19. Synergistic effect of CART (cocaine- and amphetamine-regulated transcript peptide and cholecystokinin on food intake regulation in lean mice

    Directory of Open Access Journals (Sweden)

    Kiss Alexander

    2008-10-01

    Full Text Available Abstract Background CART (cocaine- and amphetamine-regulated transcript peptide and cholecystokinin (CCK are neuromodulators involved in feeding behavior. This study is based on previously found synergistic effect of leptin and CCK on food intake and our hypothesis on a co-operation of the CART peptide and CCK in food intake regulation and Fos activation in their common targets, the nucleus tractus solitarii of the brainstem (NTS, the paraventricular nucleus (PVN, and the dorsomedial nucleus (DMH of the hypothalamus. Results In fasted C57BL/6 mice, the anorexigenic effect of CART(61-102 in the doses of 0.1 or 0.5 μg/mouse was significantly enhanced by low doses of CCK-8 of 0.4 or 4 μg/kg, while 1 mg/kg dose of CCK-A receptor antagonist devazepide blocked the effect of CART(61-102 on food intake. After simultaneous administration of 0.1 μg/mouse CART(61-102 and of 4 μg/kg of CCK-8, the number of Fos-positive neurons in NTS, PVN, and DMH was significantly higher than after administration of each particular peptide. Besides, CART(61-102 and CCK-8 showed an additive effect on inhibition of the locomotor activity of mice in an open field test. Conclusion The synergistic and long-lasting effect of the CART peptide and CCK on food intake and their additive effect on Fos immunoreactivity in their common targets suggest a co-operative action of CART peptide and CCK which could be related to synergistic effect of leptin on CCK satiety.

  20. Comparative distribution of cocaine- and amphetamine-regulated transcript (CART) in the hypothalamus of the capuchin monkey (Cebus apella) and the common marmoset (Callithrix jacchus).

    Science.gov (United States)

    Cavalcante, Judney Cley; Cândido, Paulo Laino; Sita, Luciane Valéria; do Nascimento, Expedito Silva; Cavalcante, Jeferson de Souza; de Oliveira Costa, Miriam Stela Maris; Bittencourt, Jackson Cioni; Elias, Carol Fuzeti

    2011-11-24

    Cocaine- and amphetamine-regulated transcript (CART) is widely distributed in the brain of many species. In the hypothalamus, CART neurotransmission has been implicated in diverse functions including energy balance, stress response, and temperature and endocrine regulation. Although some studies have been performed in primates, very little is known about the distribution of CART neurons in New World monkeys. New World monkeys are good models for systems neuroscience, as some species have evolved several behavioral and anatomical characteristics shared with humans, including diurnal and social habits, intense maternal care, complex manipulative abilities and well-developed frontal cortices. In the present study, we assessed the distribution of CART mRNA and peptide in the hypothalamus of the capuchin monkey (Cebus apella) and the common marmoset (Callithrix jacchus). We found that the distribution of hypothalamic CART neurons in these monkeys is similar to what has been described for rodents and humans, but some relevant differences were noticed. Only in capuchin monkeys CART neurons were observed in the suprachiasmatic and the intercalatus nuclei, whereas only in marmoset CART neurons were observed in the dorsal anterior nucleus. We also found that the only in marmoset displayed CART neurons in the periventricular preoptic nucleus and in an area seemingly comprising the premammillary nucleus. These hypothalamic sites are both well defined in rodents but poorly defined in humans. Our findings indicate that CART expression in hypothalamic neurons is conserved across species but the identified differences suggest that CART is also involved in the control of species-specific related functions.

  1. Cervical cancer survival prediction using hybrid of SMOTE, CART and smooth support vector machine

    Science.gov (United States)

    Purnami, S. W.; Khasanah, P. M.; Sumartini, S. H.; Chosuvivatwong, V.; Sriplung, H.

    2016-04-01

    According to the WHO, every two minutes there is one patient who died from cervical cancer. The high mortality rate is due to the lack of awareness of women for early detection. There are several factors that supposedly influence the survival of cervical cancer patients, including age, anemia status, stage, type of treatment, complications and secondary disease. This study wants to classify/predict cervical cancer survival based on those factors. Various classifications methods: classification and regression tree (CART), smooth support vector machine (SSVM), three order spline SSVM (TSSVM) were used. Since the data of cervical cancer are imbalanced, synthetic minority oversampling technique (SMOTE) is used for handling imbalanced dataset. Performances of these methods are evaluated using accuracy, sensitivity and specificity. Results of this study show that balancing data using SMOTE as preprocessing can improve performance of classification. The SMOTE-SSVM method provided better result than SMOTE-TSSVM and SMOTE-CART.

  2. Investigation on Superior Performance by Fractional Controller for Cart-Servo Laboratory Set-Up

    Directory of Open Access Journals (Sweden)

    Ameya Anil Kesarkar

    2014-01-01

    Full Text Available In this paper, an investigation is made on the superiority of fractional PID controller (PI^alpha D^beta over conventional PID for the cart-servo laboratory set-up. The designed controllers are optimum in the sense of Integral Absolute Error (IAE and Integral Square Error (ISE. The paper contributes in three aspects: 1 Acquiring nonlinear mathematical model for the cart-servo laboratory set-up, 2 Designing fractional and integer order PID for minimizing IAE, ISE, 3 Analyzing the performance of designed controllers for simulated plant model as well as real plant. The results show a significantly superior performance by PI^alpha D^beta as compared to the conventional PID controller.

  3. Demonstration of Launch Vehicle Slosh Instability on Pole-Cart Platform

    Science.gov (United States)

    Pei, Jing; Rothhaar, Paul

    2015-01-01

    Liquid propellant makes up a significant portion of the total weight for large launch vehicles such as Saturn V, Space Shuttle, and the Space Launch System (SLS). Careful attention must be given to the influence of fuel slosh motion on the stability of the vehicle. A well-documented slosh danger zone occurs when the slosh mass is between the vehicle center of mass and the center of percussion. Passive damping via slosh baffle is generally required when the slosh mass is within this region. The pole-cart hardware system, typically used for academic purposes, has similar dynamic characteristics as an unstable launch vehicle. This setup offers a simple and inexpensive way of analyzing slosh dynamics and its impact on flight control design. In this paper, experimental and numerical results from the pole-cart system will be shown and direct analogies to launch vehicle slosh dynamics will be made.

  4. One-dimensional collision carts computer model and its design ideas for productive experiential learning

    CERN Document Server

    Wee, Loo Kang

    2012-01-01

    We develop an Easy Java Simulation (EJS) model for students to experience the physics of idealized one-dimensional collision carts. The physics model is described and simulated by both continuous dynamics and discrete transition during collision. In the field of designing computer simulations, we discuss briefly three pedagogical considerations such as 1) consistent simulation world view with pen paper representation, 2) data table, scientific graphs and symbolic mathematical representations for ease of data collection and multiple representational visualizations and 3) game for simple concept testing that can further support learning. We also suggest using physical world setup to be augmented complimentarily with simulation while highlighting three advantages of real collision carts equipment like tacit 3D experience, random errors in measurement and conceptual significance of conservation of momentum applied to just before and after collision. General feedback from the students has been relatively positive,...

  5. Some perfect cards shuffles (French title: Quelques m\\'elanges parfaits de cartes)

    CERN Document Server

    Lachal, Aimé

    2009-01-01

    In this paper, we study some cards shuffles which are used by magicians. We focus ourselves on the possibility to hit eventually the initial state after several shuffles. This is a classical problem arising in discrete dynamical systems. The computations are performed through an elementary approach, so the paper is easily accessible. ----- Dans cet article, on \\'etudie quelques m\\'elanges de cartes bien connus du monde de la magie. On examine en d\\'etail l'\\'eventualit\\'e de reconstituer le jeu de cartes initial apr\\`es plusieurs m\\'elanges cons\\'ecutifs. Il s'agit math\\'ematiquement d'un probl\\`eme de syst\\`emes dynamiques discrets pour lequel on recherche explicitement une p\\'eriode. Les calculs \\'etant pr\\'esent\\'es de mani\\`ere \\'el\\'ementaire, l'article se veut accessible \\`a un large public.

  6. Fault detection and diagnosis of induction motors using motor current signature analysis and a hybrid FMM-CART model.

    Science.gov (United States)

    Seera, Manjeevan; Lim, Chee Peng; Ishak, Dahaman; Singh, Harapajan

    2012-01-01

    In this paper, a novel approach to detect and classify comprehensive fault conditions of induction motors using a hybrid fuzzy min-max (FMM) neural network and classification and regression tree (CART) is proposed. The hybrid model, known as FMM-CART, exploits the advantages of both FMM and CART for undertaking data classification and rule extraction problems. A series of real experiments is conducted, whereby the motor current signature analysis method is applied to form a database comprising stator current signatures under different motor conditions. The signal harmonics from the power spectral density are extracted as discriminative input features for fault detection and classification with FMM-CART. A comprehensive list of induction motor fault conditions, viz., broken rotor bars, unbalanced voltages, stator winding faults, and eccentricity problems, has been successfully classified using FMM-CART with good accuracy rates. The results are comparable, if not better, than those reported in the literature. Useful explanatory rules in the form of a decision tree are also elicited from FMM-CART to analyze and understand different fault conditions of induction motors.

  7. Pendekatan Cart untuk Mendapatkan Faktor yang Mempengaruhi Terjangkitnya Penyakit Demam Tifoid di Aceh Utara

    Directory of Open Access Journals (Sweden)

    Dina Yuanita

    2010-05-01

    research conducted to find factors that influence the outbreak of typhoid fever in NAD. research using the CART Method. The results of the analysis indicate that the main factor causing typhoid fever was drinking water reservoirs. The other factors are waste water reservoirs, the physical quality of drinking water, a habit washing hands with soap before eating, the bowel, the dump, gender, socioeconomic status, habits of washing hands with soap after defecation and health education.

  8. Energy Shaping Control of an Inverted Flexible Pendulum Fixed to a Cart

    OpenAIRE

    2016-01-01

    Control of compliant mechanical systems is increasingly being researched for several applications including flexible link robots and ultra-precision positioning systems. The control problem in these systems is challenging, especially with gravity coupling and large deformations, because of inherent underactuation and the combination of lumped and distributed parameters of a nonlinear system. In this paper we consider an ultra-flexible inverted pendulum on a cart and propose a new nonlinear en...

  9. L'eau en Franche-Comté: deux cartes pour poser des questions

    Directory of Open Access Journals (Sweden)

    Daniel JOLY

    1993-12-01

    Full Text Available Quatre couches d’information d’une banque de données ont été croisées pour fournir deux cartes prospectives. Elles montrent les zones qui poseront de plus en plus de problèmes pour la qualité de l’eau et les rejets non contrôlés.

  10. On the Stabilization of the Inverted-Cart Pendulum Using the Saturation Function Approach

    OpenAIRE

    2011-01-01

    A simple stabilizing controller for the cart-pendulum system is designed in this paper. Our control strategy describes the underactuated system as a chain of integrators with a high-order smooth nonlinear perturbation and assumes initialization of the system in the upper half plane. The design procedure involves two sequentially associated control actions: one linear and one bounded quasilinear. The first control action brings the nonactuated coordinate near to the upright position and keeps ...

  11. The Vending and à la Carte Policy Intervention in Maine Public High Schools

    Directory of Open Access Journals (Sweden)

    Anne-Marie Davee, MS, RD

    2005-11-01

    Full Text Available Background A healthy school nutrition environment may be important for decreasing childhood overweight. This article describes a project to make healthier snacks and beverages available in vending machines and à la carte programs in Maine public high schools. Context Seven public high schools in Maine volunteered to participate in this project. Four schools made changes to the nutrition environment, and three schools that served as controls did not. The nutrition guidelines were to offer only low-fat (not more than 30% of total calories from fat and low-sugar (not more than 35% by weight of sugar items in vending machines and à la carte programs. Methods Strategies to implement the project included early communications with school officials, monetary stipends for participation, identification of a school liaison, and a committee at each school to promote the healthy changes. Baseline nutrient content and sales of all competitive foods and beverages were assessed to develop the guidelines for changes in the four schools. Student volunteers at all seven schools were measured for height, weight, diet quality, and physical activity level to assess the impact of the change to the nutrition environment. Baseline measures were taken in the spring semester of 2004. Nutrition changes were made to the à la carte programs and vending machines in the four intervention schools at the start of the fall semester of 2004. Follow-up nutrition assessment and student data collection occurred in the spring semester of 2005. Consequences Healthy changes in vending machines were more easily achieved than those made in the à la carte programs. Technical assistance and ongoing support were essential for successful implementation of this intervention. Interpretation It is possible to improve the nutrition environment of Maine public high schools. Stakeholder support is essential to sustain healthy changes.

  12. Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.

    Science.gov (United States)

    Rodgers, David T; Mazagova, Magdalena; Hampton, Eric N; Cao, Yu; Ramadoss, Nitya S; Hardy, Ian R; Schulman, Andrew; Du, Juanjuan; Wang, Feng; Singer, Oded; Ma, Jennifer; Nunez, Vanessa; Shen, Jiayin; Woods, Ashley K; Wright, Timothy M; Schultz, Peter G; Kim, Chan Hyuk; Young, Travis S

    2016-01-26

    Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related to the inability to control CAR-T cells once infused into the patient remain a significant challenge. Here we report the engineering of recombinant antibody-based bifunctional switches that consist of a tumor antigen-specific Fab molecule engrafted with a peptide neo-epitope, which is bound exclusively by a peptide-specific switchable CAR-T cell (sCAR-T). The switch redirects the activity of the bio-orthogonal sCAR-T cells through the selective formation of immunological synapses, in which the sCAR-T cell, switch, and target cell interact in a structurally defined and temporally controlled manner. Optimized switches specific for CD19 controlled the activity, tissue-homing, cytokine release, and phenotype of sCAR-T cells in a dose-titratable manner in a Nalm-6 xenograft rodent model of B-cell leukemia. The sCAR-T-cell dosing regimen could be tuned to provide efficacy comparable to the corresponding conventional CART-19, but with lower cytokine levels, thereby offering a method of mitigating cytokine release syndrome in clinical translation. Furthermore, we demonstrate that this methodology is readily adaptable to targeting CD20 on cancer cells using the same sCAR-T cell, suggesting that this approach may be broadly applicable to heterogeneous and resistant tumor populations, as well as other liquid and solid tumor antigens.

  13. Registro de los cartógrafos medievales activos en el puerto de Mallorca

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    Llompart, Gabriel

    1997-12-01

    Full Text Available In medieval times, with the opening of the Atlantic trading routes at the beginning of the 14th century, the port of the Ciutat de Mallorques became important as the base of a gathering of both cartographers and copiers of maps. Today these maps are dispersed in museums throughout the world. Until the present day, these early map makers were known only through their works. Presented here is the first register of the "maestros" of navigational charts who worked in the "port of Mallorca". The documentation is taken from local notarial and administrative sources, all of which help the better clarification of their names, birthplaces, their Sitz im Leben and their methods of production, which were later surpassed and improved by the advent of the modern printing press.[fr] Le port de Ciutat de Mallorques fût très important pour l'histoire de la cartographie médiévale, parce-qu'un certain nombre de dessinateurs et copistes de cartes s'établirent là au commencement du XIV siècle, en raison de l'ouverture de la route atlantique. Maintenant, ces cartes se trouvent dispersées en diferents musées par tout le monde. Les auteurs de ces cartes étaient connus et datés jusqu'aujourd'hui à travers ses ouvrages. Dans cet article nous est donné un premier registre des maîtres de cartes de naviguer que travaillèrent au port de Majorque, provenant de sources locales, notariales et administratives, que nous permettent d'eclircir leurs noms, leur date de naissance leur Sitz im Leben et leurs méthodes de travail, peu après débordés et dépassés par la presse moderne.

  14. Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART

    OpenAIRE

    Anzinger, Joshua J.; Butterfield, Tiffany R.; Angelovich, Thomas A.; Suzanne M Crowe; PALMER, Clovis S.

    2014-01-01

    Combined antiretroviral therapy (cART) extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly. Although T-cell activation has been extensively examined in the context of cART-treated HIV infection, monocyte activation is only beginnin...

  15. Fatores de risco para mortalidade hospitalar nas reoperações valvares

    Directory of Open Access Journals (Sweden)

    BRANDÃO Carlos Manuel de Almeida

    2002-01-01

    Full Text Available OBJETIVO: Identificar fatores de risco para mortalidade hospitalar em reoperações valvares. MÉTODO: Foi realizada análise prospectiva de 194 pacientes submetidos a reoperações valvares no período entre julho de 1995 e junho de 1999. As variáveis estudadas foram: sexo, idade, classe funcional, número e tipo de operações prévias, intervalo entre as operações, caráter da operação, creatinina sérica, fração de ejeção do ventrículo esquerdo, diâmetros diastólico e sistólico do ventrículo esquerdo, pressão sistólica de ventrículo direito, atividade de protrombina, relação do tempo de tromboplastina parcial ativada, contagem de plaquetas, tempo de circulação extracorpórea, tempo de pinçamento aórtico, posição e número de valvas, tipo de procedimento, operações associadas e volume de sangramento intra-operatório. Análise univariada e multivariada foi realizada para determinar os fatores de risco para mortalidade hospitalar. RESULTADOS: A mortalidade hospitalar foi de 8,8% (17 pacientes. A análise univariada identificou as seguintes variáveis associadas a maior mortalidade: classe funcional avançada, fração de ejeção do ventrículo esquerdo baixa, atividade de protrombina baixa, creatinina elevada, tempo de circulação extracorpórea prolongado, tempo de pinçamento aórtico prolongado, procedimentos associados e volume de sangramento intra-operatório elevado. Na análise multivariada foram significativas: classe funcional IV, creatinina > 1,5 mg/dl e tempo de circulação extracorpórea > 120 minutos. CONCLUSÕES: As variáveis classe funcional IV, creatinina > 1,5 mg/dl e tempo de circulação extracorpórea > 120 minutos são fatores de risco independentes para mortalidade hospitalar nas reoperações valvares.

  16. Mortalidade por intoxicacao ocupacional relacionada a agrotoxicos, 2000-2009, Brasil

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    Vilma Sousa Santana

    2013-06-01

    Full Text Available OBJETIVO: Estimar o coeficiente de mortalidade por intoxicações ocupacionais relacionadas aos agrotóxicos no Brasil. MÉTODOS: Utilizaram-se dados do Sistema de Informações sobre Mortalidade de 2000 a 2009 referentes aos diagnósticos de intoxicação por agrotóxicos, T60.0-T60.4, T60.8 e T60.9, X48, Y18, e Z578 da CID-10, para a causa básica ou associadas; a natureza ocupacional foi identificada pelo registro no campo , e se a era na agropecuária. Foram excluídos homicídios e suicídios. Para cálculo da mortalidade, o número de trabalhadores da agropecuária foi obtido do Instituto Brasileiro de Geografia e Estatística, projeções do Sistema de Contas Nacionais. RESULTADOS: Foram encontrados registros de 2.052 óbitos por intoxicação por agrotóxicos no Brasil, dos quais 36,2% (n = 743 não continham dados sobre a ocupação. Dentre os 1.309 restantes, 679 (51,9% eram trabalhadores da agropecuária. A mortalidade por intoxicação ocupacional por agrotóxicos caiu de 0,56/100.000 (2000 a 2001 para 0,39/100.000 (2008 a 2009 entre trabalhadores no período, maior queda entre os homens que entre as mulheres. Os homens tiveram maiores estimativas de mortalidade por esse tipo de intoxicação em todos os anos. A maior parte dos óbitos foi causada por agrotóxicos do tipo organofosforados e carbamatos. O número de óbitos por esse tipo de intoxicação declinou em todas as regiões, exceto no Nordeste. CONCLUSÕES: É necessária a melhoria dos registros das declarações de óbito, em especial da ocupação e da relação dos diagnósticos com o trabalho, fundamentais para o controle e prevenção mais adequados para esses acidentes de trabalho. Atenção especial deve ser dirigida à região Nordeste do Brasil.

  17. MORTALIDADE PERINATAL EM GESTANTES DE ALTO RISCO EM UM HOSPITAL TERCIÁRIO

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    Rita de Cássia Alves Ferreira Silva

    2014-03-01

    Full Text Available Introdução: A mortalidade perinatal, é um importante indicador de qualidade da atenção médica à gestante e ao recém-nascido. Esse estudo teve como objetivo identificar possíveis causas de mortalidade perinatal em gestantes de alto risco em um hospital terciário de Porto Velho, Rondônia. Metodologia: Realizou-se um estudo transversal descritivo de julho a dezembro de 2010, sendo a amostra composta por 48 gestantes considerando período gestacional de 22 semanas ou mais. Os dados secundários foram coletados de prontuários. Foram analisadas as seguintes variáveis: tipo e evolução do parto, indicadores obstétricos e evolução clínica dos recém-nascidos. Resultados: A taxa de mortalidade perinatal foi de 35,68/1000. A maioria dos partos ocorreu em ambiente hospitalar. 28 (60,9% partos ocorreram por via vaginal, a faixa etária variou entre 15 e 43 anos. Em relação à duração da gestação, 36,2% das gestantes se encontravam entre 32 a 37 semanas. Quanto às consultas pré-natais, a maiorias das gestantes realizaram entre 3 e 4 consultas, 42,3%. Os diagnósticos maternos mais comuns foram infecção urinária (22,9% e trabalho de parto prematuro (22,9%. Em relação ao diagnóstico dos produtos, 47,9% eram natimortos e 20,8% apresentaram mal formação congênita. Conclusão: A taxa de mortalidade perinatal é elevada quando comparada com instituições similares. Infecção urinária e parto prematuro foram às causas mais frequentes de mortalidade perinatal, seguidas por eclampsia e coriamnionite.

  18. The importance of viral blips and duration of therapy initiated in primary infection in maintaining viral control after stopping cART

    Science.gov (United States)

    Fidler, Sarah; Olson, Ashley; Fox, Julie; Phillips, Andrew; Morrison, Charles; Thornhill, John; Bucher, Heiner; Muga, Roberto; Porter, Kholoud

    2014-01-01

    Introduction After achieving undetectable HIV-RNA on cART, on cessation, HIV-RNA rebounds to pre-treatment values for the majority due to the presence of an inaccessible viral reservoir. There is some evidence that cART during primary HIV infection (PHI) limits the reservoir size, optimizing the chance of maintaining viral control off cART. Data are required to predict possible viral controllers for treatment interruption following cART. This analysis aims to investigate the effect of cART duration and the rate of viral blips while on cART initiated in PHI, and other factors on maintaining viral control for those stopping cART. Material and Methods Using CASCADE data on HIV seroconverters, we characterized virologic blip (viral suppression on cART followed by a single HIV-RNA above a blip threshold and a subsequent measure below the threshold without cART change) rates for those starting cART within six months of seroconversion (SC). Using Cox models, we examined the effect of the following factors on time to virologic rebound (HIV-RNA>1000) after cART stop: cART duration, severity/rate of blips on cART, time from SC to cART start, cART class, SC year, SC age, CD4 at cART start/stop, sex and HIV risk group. Results The 660 individuals initiating cART in PHI were mostly male (91%), seroconverting between 1995 and 2012, with a median (IQR) age of 34 (29, 41) years mostly infected through sex between men (73%). Median cART duration was 14.8 (7.0, 31.7) months initiated at a median 1.9 (0.5, 3.9) months post SC. 13 (11, 16), 9 (7, 11), 6 (5, 9) and 7 (6, 10)% of individuals experienced blips >50, 100, 200 and 400 copies/mL, respectively. Of those who experienced blips, most (77–90%, depending on blip threshold) experienced just one. Among 250 individuals with undetectable HIV-RNA at cART stop, median time to rebound was 1.6 (0.30, 5.8) months. Time on cART was the only factor independently associated with control after stopping, HR for rebound=0.91 (0.86, 0.98) per

  19. Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia.

    Science.gov (United States)

    Seyoum, Zewdu; Zewdu, Alemu; Dagnachew, Shimelis; Bogale, Basazinew

    2017-01-01

    A study was conducted from November 2015 to April 2016 to determine fenbendazole and ivermectin resistance status of intestinal nematodes of cart horses in Gondar, Northwest Ethiopia. Forty-five strongyle infected animals were used for this study. The animals were randomly allocated into three groups (15 horses per group). Group I was treated with fenbendazole and Group II with ivermectin and Group III was left untreated. Faecal samples were collected from each cart horse before and after treatment. Accordingly, the reduction in the mean fecal egg count at fourteen days of treatment for ivermectin and fenbendazole was 97.25% and 79.4%, respectively. It was significantly different in net egg count between treatment and control groups after treatment. From the study, resistance level was determined for fenbendazole and suspected for ivermectin. In addition, a questionnaire survey was also conducted on 90 selected cart owners to assess their perception on anthelmintics. In the survey, the most available drugs in the study area used by the owners were fenbendazole and ivermectin. Most respondents have no knowledge about drug management techniques. Hence, animal health extension services to create awareness regarding anthelmintic management that plays a key role in reducing the anthelmintic resistance parasites.

  20. Automated Cart with VIS/NIR Hyperspectral Reflectance and Fluorescence Imaging Capabilities

    Directory of Open Access Journals (Sweden)

    Alan M. Lefcourt

    2016-12-01

    Full Text Available A system to take high-resolution Visible/Near Infra-Red (VIS/NIR hyperspectral reflectance and fluorescence images in outdoor fields using ambient lighting or a pulsed laser (355 nm, respectively, for illumination purposes was designed, built, and tested. Components of the system include a semi-autonomous cart, a gated-intensified camera, a spectral adapter, a frequency-triple Nd:YAG (Neodymium-doped Yttrium Aluminium Garnet laser, and optics to convert the Gaussian laser beam into a line-illumination source. The front wheels of the cart are independently powered by stepper motors that support stepping or continuous motion. When stepping, a spreadsheet is used to program parameters of image sets to be acquired at each step. For example, the spreadsheet can be used to set delays before the start of image acquisitions, acquisition times, and laser attenuation. One possible use of this functionality would be to establish acquisition parameters to facilitate the measurement of fluorescence decay-curve characteristics. The laser and camera are mounted on an aluminum plate that allows the optics to be calibrated in a laboratory setting and then moved to the cart. The system was validated by acquiring images of fluorescence responses of spinach leaves and dairy manure.

  1. Detection of Neospora sp. antibodies in cart horses from urban areas of Curitiba, Southern Brazil.

    Science.gov (United States)

    Villalobos, Eliana Monteforte Cassaro; Furman, Keiko Endo; Lara, Maria do Carmo Custódio de Souza Hunold; Cunha, Elenice Maria Sequetin; Finger, Mariane Angélica; Busch, Ana Paula Brenner; de Barros Filho, Ivan Roque; Deconto, Ivan; Dornbusch, Peterson Triches; Biondo, Alexander Welker

    2012-01-01

    Neospora caninum is a protozoan parasite which affects dogs as definitive hosts and several mammalian species as intermediate hosts mainly causing abortions and central nervous system disorders. The reemerging population of cart horses for carrying recycling material in urban areas of major cities in Brazil may have an impact on disease spreading, and these animals may be used as sentinels for environmental surveillance. Thus, the present study investigated the frequency of Neospora sp. antibodies in cart horses from Curitiba and surrounding areas, Paraná State, Southern Brazil. IgG antibodies against Neospora sp. were detected using indirect fluorescence antibody test (IFAT), and titers equal to or higher than 1:50 were considered reactive. Of all samples, 14/97 (14.4%) were positive: 2/29 (6.9%) were younger than 5; 5/26 (19.2%) between 6 and 9; and 6/31 (19.4%) older than 10 years of age. One of the 11 animals with unknown age was positive (9.1%). Cart horses are likely to be more exposed to dog feces and to Neospora sp. oocyst contamination in urban settings and a lower frequency of disease in dogs may have a negative impact on horse infection risk in these areas.

  2. Echocardiographic measurement of cart horses in the metropolitan region of Curitiba-PR

    Directory of Open Access Journals (Sweden)

    Amália Turner Giannico

    2015-04-01

    Full Text Available In order to maintain the horses’ performance during the exercise, their hearts adapt to the variations on metabolic activity, resulting in muscular adaptation. Thus, echocardiography allows to assess on both eventual adaptations of heart tissue and impairment of the ability to pump blood. Little is yet known about echocardiography in cart horses, whose general conditions of health and treatment are often inappropriate to the type of exercise they are submitted to. The goal of this study was to establish echocardiographic numbers for cart horses. Nineteen mongrel horses were submitted for echocardiographic examination, and values of the distance from E point (maximum opening mitral valve to the interventricular septum; diameter of left ventricle cavity, interventricular septum thickness and thickness of left ventricle free wall during systole and diastole, fractional shortening and ejection fraction were obtained by M-mode. In the 2D images, diameter of the aortic valve and left atrium were evaluated, and their relationship. The velocities of the blood flow were evaluated in aorta and pulmonary artery and the mitral valve by means of Doppler, and possible insufficiency was detected through the color Doppler. Mean values for echocardiographic parameters were established considering 19 traction horses that worked pulling cart loads. There were no significant values that indicated either an inappropriate cardiac remodeling, a left ventricular dysfunction – with consequent decrease in exercises performance – or diseases that affect the animal’s performance at work.

  3. Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia

    Directory of Open Access Journals (Sweden)

    Zewdu Seyoum

    2017-01-01

    Full Text Available A study was conducted from November 2015 to April 2016 to determine fenbendazole and ivermectin resistance status of intestinal nematodes of cart horses in Gondar, Northwest Ethiopia. Forty-five strongyle infected animals were used for this study. The animals were randomly allocated into three groups (15 horses per group. Group I was treated with fenbendazole and Group II with ivermectin and Group III was left untreated. Faecal samples were collected from each cart horse before and after treatment. Accordingly, the reduction in the mean fecal egg count at fourteen days of treatment for ivermectin and fenbendazole was 97.25% and 79.4%, respectively. It was significantly different in net egg count between treatment and control groups after treatment. From the study, resistance level was determined for fenbendazole and suspected for ivermectin. In addition, a questionnaire survey was also conducted on 90 selected cart owners to assess their perception on anthelmintics. In the survey, the most available drugs in the study area used by the owners were fenbendazole and ivermectin. Most respondents have no knowledge about drug management techniques. Hence, animal health extension services to create awareness regarding anthelmintic management that plays a key role in reducing the anthelmintic resistance parasites.

  4. Comment ouvrir un compte bancaire et avoir une carte bancaire en France

    Institute of Scientific and Technical Information of China (English)

    应小华

    2011-01-01

    Si vous allez habiter en France pour longtemps,il est nécessaire d'ouvrir un compte bancaire et d'avoir une carte bancaire.Avec la carte bancaire,la consommation devient plus agréable et pratique,et vous n'avez plus besoin de sortir avec beaucoup d'argent.Aujourd'hui,en France,à presque tous les endroits,vous pourriez payer avec une carte bancaire:au restaurant,au supermarché,à la station de métro,et sur Internet,etc.De plus,pour bénéficier d'une aide au logement1 et acheter un forfait portable2 (qui co(u)te généralement moins cher que les appels sans engagement) dont on parlera dans les textes suivants,il vous faut aussi un relevé d'identité bancaire (RIB)3 délivré par votre banque.

  5. HIV-Associated Hodgkin's Lymphoma: Prognosis and Therapy in the Era of cART

    Directory of Open Access Journals (Sweden)

    Caron A. Jacobson

    2012-01-01

    Full Text Available Patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS are at increased risk for developing Hodgkin's lymphoma (HL, a risk that has not decreased despite the success of combination antiretroviral therapy (cART in the modern era. HIV-associated HL (HIV-HL differs from HL in non-HIV-infected patients in that it is nearly always associated with Epstein-Barr virus (EBV and more often presents with high-risk features of advanced disease, systemic “B” symptoms, and extranodal involvement. Before the introduction of cART, patients with HIV-HL had lower response rates and worse outcomes than non-HIV-infected HL patients treated with conventional chemotherapy. The introduction of cART, however, has allowed for the delivery of full-dose and dose-intensive chemotherapy regimens with improved outcomes that approach those seen in non-HIV infected patients. Despite these significant advances, HIV-HL patients remain at increased risk for treatment-related toxicities and drug-drug interactions which require careful attention and supportive care to insure the safe administration of therapy. This paper will address the modern diagnosis, risk stratification, and therapy of HIV-associated HL.

  6. Fuzzy coordinator compensation for balancing control of cart-seesaw system

    Science.gov (United States)

    Lin, J.; Guo, S.-Y.; Chang, Julian

    2011-12-01

    In contrast with fully controllable systems, a super articulated mechanical system (SAMS) is a controlled underactuated mechanical system in which the dimensions of the configuration space exceed the dimensions of the control input space. The control of the cart-seesaw system is especially difficult since it is an underactuated mechanism (three degrees of freedom and only two inputs). This research develops a balancing approach for a novel SAMS model, called the cart-seesaw system, using fuzzy logic and fuzzy coordinator compensation to drive the sliding carts and keep the seesaw angle close to zero in the equilibrium state. Experimental results indicate that utilizing the proposed control methodology significantly enhances the performance. Moreover, the presentation of the fuzzy balancing controller is not considerably affected by changes in the environmental parameters, which demonstrates the effectiveness of the fuzzy controller in minimizing the seesaw tilt angle in the time domain, although the system is caused by unpredicted loading variation. Moreover, the experimental results indicate the usefulness and robustness of the proposed fuzzy control methodology. Furthermore, the proposed software/hardware platform can be beneficial for standardizing laboratory equipment and developing amusement apparatus.

  7. A Novel Biped Pattern Generator Based on Extended ZMP and Extended Cart-table Model

    Directory of Open Access Journals (Sweden)

    Guangbin Sun

    2015-07-01

    Full Text Available This paper focuses on planning patterns for biped walking on complex terrains. Two problems are solved: ZMP (zero moment point cannot be used on uneven terrain, and the conventional cart-table model does not allow vertical CM (centre of mass motion. For the ZMP definition problem, we propose the extended ZMP (EZMP concept as an extension of ZMP to uneven terrains. It can be used to judge dynamic balance on universal terrains. We achieve a deeper insight into the connection and difference between ZMP and EZMP by adding different constraints. For the model problem, we extend the cart-table model by using a dynamic constraint instead of constant height constraint, which results in a mathematically symmetric set of three equations. In this way, the vertical motion is enabled and the resultant equations are still linear. Based on the extended ZMP concept and extended cart-table model, a biped pattern generator using triple preview controllers is constructed and implemented simultaneously to three dimensions. Using the proposed pattern generator, the Atlas robot is simulated. The simulation results show the robot can walk stably on rather complex terrains by accurately tracking extended ZMP.

  8. Modelo preditivo de óbito a partir de dados do Sistema de Informações Hospitalares Modelo predictivo de óbito a partir de datos del Sistema de Informaciones Hospitalarias Mortality prediction model using data from the Hospital Information System

    Directory of Open Access Journals (Sweden)

    Andréa Silveira Gomes

    2010-10-01

    .OBJETIVO: Desarrollar un modelo predictivo de óbito hospitalario con base en los datos del Sistema de Informaciones Hospitalarios del Sistema Único de Salud de Brasil. MÉTODOS: Estudio transversal con datos de 453.515 autorizaciones de internación de 332 hospitales de Rio Grande do Sul (Sur de Brasil en el año 2005. A partir de la tasa de óbitos observados y óbitos esperados se elaboró un ranking ajustado de los hospitales que fue comparado al ranking bruto de la tasa de mortalidad. Se utilizó regresión logística para desarrollo del modelo predictivo de probabilidad para óbito hospitalario según sexo, edad, diagnóstico y uso de unidad de terapia intensiva (UTI. Se obtuvieron los intervalos con 95% de confianza para los 206 hospitales con más de 365 internaciones por año. RESULTADOS: Se obtuvo un índice de riesgo para mortalidad hospitalaria. La ordenación de los hospitales utilizando sólo la tasa de mortalidad bruta difirió de la ordenación al utilizarse el ranking ajustado por el modelo predictivo de probabilidad. De los 206 hospitales analizados, 40 hospitales presentaron mortalidad observada significativamente superior a la esperada y 58 hospitales con mortalidad significativamente menor a la esperada. El uso de UTI presentó mayor peso para la composición del índice de riesgo, seguida por la edad y diagnóstico. Cuando los hospitales atienden pacientes con perfiles muy diferentes, el ajuste de riesgo no resulta en una indicación definitiva sobre cual prestador es mejor. Los hospitales de gran porte presentaron, en conjunto, mayor número de óbitos del que sería esperado de acuerdo con las características de las internaciones. CONCLUSIONES: El índice de riesgo de óbito hospitalario se mostró predictivo adecuado para el cálculo de los óbitos esperados, pudiendo ser aplicado en la evaluación del desarrollo hospitalario. Se recomienda que, al comparar hospitales, sea utilizado el ajuste por el modelo predictivo de probabilidad de riesgo, estratific

  9. Salud mental en adultos mayores atendidos en la red hospitalaria pública de Medellín, Colombia

    Directory of Open Access Journals (Sweden)

    Andrés A Agudelo-Suárez

    Full Text Available Objetivos. Determinar la prevalencia de mala salud mental y sus factores asociados en adultos mayores atendidos en la Empresa Social del Estado (ESE Metrosalud. Materiales y métodos. Estudio transversal mediante muestreo bietápico en las unidades hospitalarias y centros de salud adscritos a la red de la ESE Metrosalud de Medellín. Participaron 342 adultos de 65 y más años (58,2% mujeres. Variables: mala salud mental (medida con el GHQ12, apoyo social (Duke-11; sociodemográficas: edad, sexo, estrato socioeconómico, nivel educativo, zona de residencia, estado civil, y ocupación. Se describieron las variables del estudio, se calculó la prevalencia total de acuerdo con las variables sociodemográficas, y se estimó la asociación de mala salud mental de acuerdo con variables seleccionadas calculando Odds Ratio con sus intervalos de confianza al 95% ajustado por posibles variables confusoras mediante regresión logística. Resultados. La población adulta mayor sin estudios de ambos sexos (ORa 7,61; IC 95%: 2,49-23,34, las mujeres viudas (ORa 2,78; IC 95%: 1,21-6,40 y los hombres y mujeres con bajo apoyo social (ORa 3,05; IC 95%: 1,65- 5,66, reportaron mayor riesgo de mala salud mental, con respecto a sus contrapartes de referencia. Conclusiones. Se encontró una alta prevalencia de mala salud mental en la población estudiada, con diferencias de acuerdo con factores sociodemográficos, lo que sugiere la situación de vulnerabilidad social en este colectivo que impacta en su situación de salud. Se requieren estrategias y políticas sociales y de salud que contribuyan al bienestar de este grupo poblacional

  10. Nutritional assessment associated with length of inpatients' hospital stay Evaluación nutricional asociada con la estancia hospitalaria

    Directory of Open Access Journals (Sweden)

    H. G. Valente da Silva

    2012-04-01

    Full Text Available Objective: To evaluate the nutritional status of patients on hospital admission, identify the length of hospital stay and identify the parameters of nutritional assessment that are most closely related with the length of stay (LOS. Methods: A cross-sectional study of 278 hospitalized patients evaluated patients´ nutritional status in the 48 hours after admission and their LOS after discharge. Anthropometric and biochemical parameters, related to nutrition status were analyzed, such as: weight, height, arm circumference (AC, waist circumference (WC, triceps skinfold thickness (TST, mild arm muscle circumference (MAMC, albumin (Alb and hemoglobin (HB. Body mass index (BMI was used to classify the nutritional status. All the nutritional factors except type of disease, gender and age were associated with LOS. The chi-square, Student-t, Mann-Whitney, Kruskal-Wallis and binary logistic multivariate tests were used in the statistical analyses. Results: The majority of patients was male (53%, elderly (56% and had neoplasm (19.4%. Undernutrition was higher in the elderly (p Objetivo: Evaluar el estado nutricional de los pacientes ingresados en el hospital, identificar la duración de la estancia hospitalaria e identificar los parámetros de la evaluación nutricional que se relacionen más estrechamente con la duración de la estancia (DE. Métodos: Se evaluó en un estudio transversal con 278 pacientes hospitalizados el estado nutricional en las 48 horas siguientes al ingreso y su DE tras el alta. Se analizaron los parámetros antropométricos y bioquímicos en relación con el estado nutricional, tales como: peso, talla, circunferencia del brazo (CB, circunferencia de la cintura (CC, el grosor del pliegue cutáneo tricipital (GPT, la circunferencia de la musculatura del brazo (CMB, la albúmina (Alb y la hemoglobina (HB. Se empleó el índice de masa corporal (IMC para clasificar el estado nutricional. Todos los factores nutricionales salvo el tipo de

  11. Integration of stress and leptin signaling by CART producing neurons in the rodent midbrain centrally projecting Edinger-Westphal nucleus

    Directory of Open Access Journals (Sweden)

    Lu eXu

    2014-03-01

    Full Text Available Leptin targets the brain to regulate feeding, neuroendocrine function and metabolism. The leptin receptor is present in hypothalamic centers controlling energy metabolism as well as in the centrally projecting Edinger-Westphal nucleus (EWcp, a region implicated in the stress response and in various aspects of stress-related behaviors. We hypothesized that the stress response by cocaine- and amphetamine-regulated transcript (CART-producing EWcp-neurons would depend on the animal’s energy state. To test this hypothesis, we investigated the effects of changes in energy state (mimicked by low, normal and high leptin levels, which were achieved by 24h fasting, normal chow and leptin injection, respectively on the response of CART neurons in the EWcp of rats subjected or not to acute restraint stress. Our data show that leptin treatment alone significantly increases CART mRNA expression in the rat EWcp and that in leptin receptor deficient (db/db mice, the number of CART producing neurons in this nucleus is reduced. This suggests that leptin has a stimulatory effect on the production of CART in the EWcp under non-stressed condition. Under stressed condition, however, leptin blunts stress-induced activation of EWcp neurons and decreases their CART mRNA expression. Interestingly, fasting, does not influence the stress-induced activation of EWcp-neurons, and specifically EWcp-CART neurons are not activated. These results suggest that the stress response by the EWcp depends to some degree on the animal’s energy state, a mechanism that may contribute to a better understanding of the complex interplay between obesity and stress.

  12. Lack of viral control and development of cART escape mutations in macaques after bone marrow transplantation

    Science.gov (United States)

    PETERSON, Christopher W.; HAWORTH, Kevin G.; POLACINO, Patricia; HUANG, Meei-Li; SYKES, Craig; OBENZA, Willimark M.; REPETTO, Andrea C.; KASHUBA, Angela; BUMGARNER, Roger; DeROSA, Stephen C.; WOOLFREY, Ann E.; JEROME, Keith R.; MULLINS, James I.; HU, Shiu-Lok; KIEM, Hans-Peter

    2015-01-01

    Objective We have previously demonstrated robust control of simian/human immunodeficiency virus (SHIV1157-ipd3N4) viremia following administration of combination antiretroviral therapy (cART) in pigtailed macaques. Here, we sought to determine the safety of hematopoietic stem cell transplantation (HSCT) in cART-suppressed and unsuppressed animals. Design We compared disease progression in animals challenged with SHIV 100 days post-transplant (PT), to controls that underwent transplant following SHIV challenge and stable, cART-dependent viral suppression. Methods SHIV viral load, combination antiretroviral therapy (cART) levels, and anti-SHIV antibodies were measured longitudinally from plasma/serum from each animal. Flow cytometry was used to assess T-cell subset frequencies in peripheral blood and gastrointestinal tract (GI). Deep sequencing was used to identify cART resistance mutations. Results In control animals, virus challenge induced transient peak viremia, viral set point, and durable suppression by cART. Subsequent HSCT was not associated with adverse events in these animals. PT animals were challenged during acute recovery following HSCT, and displayed sustained peak viremia and cART resistance. Although PT animals had comparable plasma levels of antiretroviral drugs and showed no evidence of enhanced infection of myeloid subsets in the periphery, they exhibited a drastic reduction in virus-specific antibody production and decreased T-cell counts. Conclusions These results suggest that virus challenge prior to complete transplant recovery impairs viral control and may promote drug resistance. These findings may also have implications for scheduled treatment interruption (STI) studies in patients on cART during post-HSCT recovery: premature STI could similarly result in lack of viral control and cART resistance. PMID:26372270

  13. Integration of stress and leptin signaling by CART producing neurons in the rodent midbrain centrally projecting Edinger-Westphal nucleus.

    Science.gov (United States)

    Xu, Lu; Janssen, Donny; van der Knaap, Noortje; Roubos, Eric W; Leshan, Rebecca L; Myers, Martin G; Gaszner, Balázs; Kozicz, Tamás

    2014-01-01

    Leptin targets the brain to regulate feeding, neuroendocrine function and metabolism. The leptin receptor is present in hypothalamic centers controlling energy metabolism as well as in the centrally projecting Edinger-Westphal nucleus (EWcp), a region implicated in the stress response and in various aspects of stress-related behaviors. We hypothesized that the stress response by cocaine- and amphetamine-regulated transcript (CART)-producing EWcp-neurons would depend on the animal's energy state. To test this hypothesis, we investigated the effects of changes in energy state (mimicked by low, normal and high leptin levels, which were achieved by 24 h fasting, normal chow and leptin injection, respectively) on the response of CART neurons in the EWcp of rats subjected or not to acute restraint stress. Our data show that leptin treatment alone significantly increases CART mRNA expression in the rat EWcp and that in leptin receptor deficient (db/db) mice, the number of CART producing neurons in this nucleus is reduced. This suggests that leptin has a stimulatory effect on the production of CART in the EWcp under non-stressed condition. Under stressed condition, however, leptin blunts stress-induced activation of EWcp neurons and decreases their CART mRNA expression. Interestingly, fasting, does not influence the stress-induced activation of EWcp-neurons, and specifically EWcp-CART neurons are not activated. These results suggest that the stress response by the EWcp depends to some degree on the animal's energy state, a mechanism that may contribute to a better understanding of the complex interplay between obesity and stress.

  14. Propuesta de intervención para trabajar la emoción del miedo en alumnos de Educación Infantil de un aula hospitalaria

    OpenAIRE

    2015-01-01

    El miedo es una de las emociones más frecuentes en los niños de edad temprana, y una de las que más angustia y ansiedad provocan, máxime en un contexto como el hospitalario. El objetivo general es realizar una aproximación teórico-práctica de la inteligencia emocional en niños de entre 3 y 6 años en un aula hospitalaria. Para contextualizar el trabajo el marco teórico se centra en cuatro aspectos fundamentales. En primer lugar se ha realizado un acercamiento a la inteligencia emocional,...

  15. Evaluación de la respuesta educativa al alumnado de aulas hospitalarias en la provincia de Almería

    OpenAIRE

    Antonio Sánchez Palomino; Damián López Sánchez

    2016-01-01

    Con esta investigación, que forma parte de una tesis doctoral en proceso, pretendemos evaluar la respuesta educativa ofrecida al alumnado de las aulas hospitalarias ubicadas en la provincia de Almería (Complejo Hospitalario de Torrecárdenas, Hospital del Poniente y Hospital La Inmaculada). Para ello, hemos utilizado como grupos informantes a los tres colectivos presentes, alumnado, familiares y personal médico-sanitario.Utilizamos como técnica de recogida de información el sistema de encuesta...

  16. Evaluación de la respuesta educativa al alumnado de aulas hospitalarias en la provincia de Almería

    OpenAIRE

    Antonio SÁNCHEZ PALOMINO

    2016-01-01

    Con esta investigación, que forma parte de una tesis doctoral en proceso, pretendemos evaluar la respuesta educativa ofrecida al alumnado de las aulas hospitalarias ubicadas en la provincia de Almería (Complejo Hospitalario de Torrecárdenas, Hospital del Poniente y Hospital La Inmaculada). Para ello, hemos utilizado como grupos informantes a los tres colectivos presentes, alumnado, familiares y personal médico-sanitario. Utilizamos como técnica de recogida de información el sistema de encues...

  17. Resistencia y susceptibilidad de microorganismos aislados en pacientes atendidos en una institución hospitalaria de tercer nivel, Villavicencio-Colombia, 2012

    OpenAIRE

    Oscar Alexander Gutiérrez Lesmes

    2015-01-01

    Introducción: La resistencia bacteriana es problema significativo de salud pública y está asociada al uso indiscriminado e irracional de antibióticos, lo que afecta la eficacia de los tratamientos. Objetivo: Estimar la resistencia antimicrobiana a los antibióticos resultado de las pruebas invitro de susceptibilidad en una institución hospitalaria de tercer nivel de Villavicencio, Colombia. Materiales y Métodos: Se realizó un estudio observacional, descriptivo de tipo retrospectivo, análisis u...

  18. Percepción del cuidado de enfermería en diferentes instituciones hospitalarias de la ciudad de bogotá

    OpenAIRE

    2012-01-01

    El estudio elaborado por los participantes del grupo de cuidado de la Universidad Nacional pertenecientes a diferentes Instituciones de Salud de Bogotá, D. C., establece cuál es la percepción del cuidado de Enfermería en diferentes Instituciones Hospitalarias de la ciudad de Bogotá: Clínica Country, Hospital Materno Infantil, Fundación Santa Fe, Hospital Santa Clara, UDCA, a través de la aplicación del instrumento de satisfacción (CARE SAT) de Patricia Larson (1993). Dicho Instrumento s...

  19. Psicoterapia dinámica breve realizada en una unidad de agudos hospitalaria de salud mental. A propósito de un caso.

    Directory of Open Access Journals (Sweden)

    María Luisa Gutiérrez López

    2011-01-01

    Full Text Available Se expone una experiencia en psicoterapia inámica breve realizada en un varón de 48 años,ingresado en una Unidad de Agudos Hospitalaria de Salud Mental. Modelo de psicoterapia breve dirigida a trabajar la afectividad del paciente, haciendo del sentimiento el foco terapéutico y de la adquisición de un mejor manejo de éstos, el objetivo principal. Con el propósito de obtener herramientas psicoterapéuticas útiles allí donde la limitación temporal es un hándicap fundamental.

  20. Objetivos de prácticas asistenciales en la unidad de urgencias hospitalarias. Percepción del alumnado sobre su cumplimiento.

    OpenAIRE

    Sancho Sánchez, M.J.; Loro Sancho, N.; Sancho Sánchez, M.T; Peiró Andrés, M.A.

    2003-01-01

    El objetivo de este trabajo se centra en medir el aprendizaje de determinadas técnicas, la aportación de los seminarios impartidos, las preferencias del alumno en cuanto a su ubicación y el grado de satisfacción dentro de la unidad en las prácticas asistenciales de un grupo de 25 estudiantes de enfermería de tercer curso, correspondiente al curso 2002-2003, que realizaron sus prácticas asistenciales (médico quirúrgica II) en una unidad de urgencias hospitalarias.

  1. Epidemiología de la infección hospitalaria por Pseudomonas aeruginosa multirresistente en niños quemados críticos

    OpenAIRE

    Halabe, Karina; Basílico, Hugo; Guarracino, Jorge F.; Murruni, Alberto

    2009-01-01

    El aumento de la prevalencia de Pseudomonas aeruginosa multirresistente ocasiona un desafío terapéutico constante en las Unidades de Cuidados Intensivos en general y de Quemados en particular. El presente trabajo epidemiológico reveló una tasa de infecciones hospitalarias de 18,91/1000 pacientes/día, con un total de 63 episodios. La tasa de bacteriemia asociada a vía venosa central (VVC) fue de 13,48/1000 días de uso de VVC, con una tasa de uti...

  2. CONFLICTO GENERADO POR LA DESIGNACIÓN DE ENFERMERAS PARA LA DIRECCIÓN HOSPITALARIA - UNA VISIÓN PERIODÍSTICA

    OpenAIRE

    2008-01-01

    El articulo de investigación, presenta un conflito de transcendencia nacional, generado por la designación de Enfermeras como directoras de hospitales públicos, en dos Instituciones Chilenas en la visión de los periodistas. Tiene por objetivos realizar un análisis crítico del impacto político-social de la toma de poder de las enfermeras durante la gestión hospitalaria, y discutir las intervenciones de los diferentes grupos, basado en una reflexión científica del poder, presentando las posicio...

  3. Mortalidade por leucemias relacionada à industrialização Mortality by industrialization-related leukemias

    Directory of Open Access Journals (Sweden)

    Carmen Helena Seoane Leal

    2002-08-01

    Full Text Available OBJETIVO: Analisar a distribuição espacial da mortalidade por leucemia na população, buscando identificar agregados e estabelecer sua relação com os níveis de industrialização. MÉTODOS: O estudo foi realizado nas 43 regiões de governo do Estado de São Paulo, no qüinqüênio 1991-1995. Foi construído um "índice de industrialização relativo à leucemia" (IIRL baseado no número de indústrias e empregos industriais por 100.000 habitantes, valor adicionado fiscal, variedade de ramos industriais e indústrias com potenciais exposições de risco para a leucemia. O IIRL foi distribuído em cinco categorias. Verificaram-se os coeficientes padronizados de mortalidade por leucemia em cada uma das regiões, também distribuídos em cinco categorias e comparados ao mapa IIRL. RESULTADOS: As regiões mais industrializadas em ordem decrescente foram Campinas, Piracicaba, Jundiaí, Sorocaba e São Paulo. Não foi encontrada associação entre mortalidade, por nenhum tipo de leucemia, e industrialização. A região de Jales foi a que apresentou o mais alto coeficiente padronizado de mortalidade por leucemia. CONCLUSÕES: A distribuição da mortalidade por leucemia ocorreu de forma homogênea no Estado de São Paulo, não apresentando correlação com o nível de industrialização. Entretanto, aspectos relacionados ao método epidemiológico adotado -- estudo ecológico -- e ao uso do parâmetro "mortalidade por leucemia", doença cujo prognóstico tem mudado muito nas últimas décadas, limitaram a interpretação dos resultados.OBJECTIVE: To analyze the spatial distribution of mortality by leukemia in the population, looking for clusters, and to establish an association with the level of industrialization. METHOD: The study was carried out in 43 state regions of the state of São Paulo, Brazil, in the period between 1991 and 1995. It was created an Index of Industrialization-Related Leukemia (IIRL based on number of manufactures and

  4. Factores de riesgo relacionados con la mortalidad por traumatismo Craneoencefálico Severo

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    Andrés Andrés Matos

    2011-01-01

    Full Text Available Presenta un estudio descriptivo en pacientes ingresados en la Unidad de Cuidados Intensivos Pediátricos con trauma craneoencefálico severo, durante el periodo comprendido entre los años 2008-2010, con el objetivo de analizar los factores de riesgo relacionados con la mortalidad por esa causa. La edad más representada fue la comprendida entre los 11-15 años (56.90%, los pacientes incluidos en el grupo de 1-5 años resultaron más vulnerables al desarrollo de complicaciones médicas. Las fracturas inestables (62.96%, la rotura de vísceras macizas (51.85% y la insuficiencia respiratoria (44.44% fueron las manifestaciones clínicas más evidentes al momento del ingreso. En la Unidad de Cuidados Intensivos las complicaciones médicas frecuentes resultaron ser los trastornos hidroelectrolíticos (94.28% y la desnutrición (77.14%, la hiperglicemia y el distrés respiratorio se relacionaron de manera significativa con la mortalidad. El 92.59% de los fallecidos sumaron tres puntos en la Escala de Glasgow. El sexo y la ventilación mecánica fueron independientes de las complicaciones médicas. Se concluye que los principales factores de riesgo asociados a la mortalidad por trauma de cráneo fueron la edad de 1-5 años, el shock hipovolémico, el distrés respiratorio y presentar puntuación de tres en la Escala de Coma de Glasgow.

  5. Mortalidad en la población galesa de Gaiman, provincia de Chubut, Argentina

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    Caratini, Alicia Liliana

    2005-01-01

    Full Text Available El objetivo de este trabajo es analizar la evolución en el tiempo de las defunciones y de las causas de muerte por edad y sexo de la población galesa de Gaiman, provincia de Chubut, Argentina. Los datos fueron obtenidos de las Actas de Defunción del Archivo del Registro Civil de la ciudad de Rawson, Chubut. El período de estudio se extendió de 1892 a 1961 y para su descripción y análisis se lo dividió en decenios. Se registraron 2103 defunciones de las cuales 1039 (49% correspondieron a galeses y sus descendientes, lo cual representa un promedio de 14.6 muertes por año. Se detectó una sobremortalidad masculina (59%, esperable en una población colonizadora con predominio de varones. Se observó un incremento, en el tiempo, de la edad media de defunción, lo que indica mejoras en las condiciones socioeconómicas y de salud de la población. La mortalidad infantil y los natimortos representaron el 20% y el 11%, respectivamente, de las defunciones y se constató una transición desde una mortalidad provocada por enfermedades de naturaleza exógena a otra de causalidad endógena. Al compararse nuestros datos con los de la provincia de Chubut y el país, se comprobó, en todos los casos, un descenso de la mortalidad en el tiempo, aunque en Gaiman esa disminución fue más significativa, probablemente por la atención que la comunidad le dedicaba a la educación y a la salud.

  6. Variación estacional de la mortalidad por homicidio en Colombia, 1985 a 2001

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    María de los Ángeles Rodríguez

    2008-06-01

    Full Text Available Introducción: El homicidio en Colombia tuvo un ascenso exponencial desde el año 1986, y alcanzó proporciones epidémicas en 1991, cuando se asesinó a ocho de cada 10,000 colombianos. Luego esta situación se redujo, pero de todas formas conservó tasas muy altas. Esta causa de muerte, es el indicador de una violencia compleja, que se agrava, además, por sus más de 50 años de duración.Objetivo: Evaluar la evolución de la variación estacional de la mortalidad por homicidio en Colombia, durante el período de 1985 a 2001. Materiales y métodos: Se estudiaron las defunciones por homicidio ocurridas durante el período entre enero de 1985 y diciembre de 2001. Con ayuda del programa SSS1 se efectuó un análisis de series temporales, mediante procedimientos iterativos de construcción de modelos ARIMA.Resultados: La tasa promedio mensual de mortalidad por homicidio fue 5.26 por 100,000 (mínimo, 2.41 en abril de 1985 y máximo, 8.67 en diciembre de 1992. Se observa un incremento en los años 1991 a 1993 de la serie. Tras el estudio de varios modelos se llegó al ARIMA (1,1,1 (0,0,112.Conclusiones: Se encontró una marcada variación estacional por año en Colombia para la mortalidad por homicidio y se observó que el mes de diciembre tenía las tasas más altas.

  7. Factores asociados a mortalidad perinatal en el hospital general de Chiapas, México

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    Rivera Leonor

    2003-01-01

    Full Text Available OBJETIVO: El objetivo del estudio es identificar factores socioeconómicos, gineco-obstétricos y del producto asociados a mortalidad perinatal. MÉTODOS: Se realizó un estudio de casos y controles pareado. Se consideró caso a los nacidos vivos o muertos que nacieron y fallecieron entre las 28 semanas de gestación a los 7 días de vida extrauterina. y control al producto nacido vivo entre las 28 semanas de gestación y los 7 días de vida extrauterina. Los datos se obtuvieron de los expedientes clínicos hospitalarios. Se estudiaron 99 casos y 197 controles. Se hizo un análisis estadístico utilizando Stata 6.0. RESULTADOS La media de edad de la madre fue de 24.82 años y del producto de 37.78 semanas de gestación. El promedio de peso del producto fue de 2,760 gramos. Los factores asociados a mortalidad perinatal fueron: ocupación del padre agricultor (RM ajustada 3,31; IC 95% 1,26-8,66; índice de riesgo obstétrico alto (RM ajustada 10,57; IC 95% 2,82-39,66, antecedente de cesárea (RM ajustada 2,75; IC 95% 1,37-5,51; cinco y más consultas prenatales (RM ajustada 4,43; IC 95% 1.86-10,54; producto pretérmino (RM ajustada 9,20; IC 95% 4,39-19,25. CONCLUSIONES: Los resultados muestran que es necesario implementar medidas de prevención y control que aseguren la identificación del riesgo en las mujeres embarazadas, con el fin de abatir la incidencia de mortalidad perinatal.

  8. Factores asociados a mortalidad perinatal en el hospital general de Chiapas, México

    Directory of Open Access Journals (Sweden)

    Leonor Rivera

    2003-12-01

    Full Text Available OBJETIVO: El objetivo del estudio es identificar factores socioeconómicos, gineco-obstétricos y del producto asociados a mortalidad perinatal. MÉTODOS: Se realizó un estudio de casos y controles pareado. Se consideró caso a los nacidos vivos o muertos que nacieron y fallecieron entre las 28 semanas de gestación a los 7 días de vida extrauterina. y control al producto nacido vivo entre las 28 semanas de gestación y los 7 días de vida extrauterina. Los datos se obtuvieron de los expedientes clínicos hospitalarios. Se estudiaron 99 casos y 197 controles. Se hizo un análisis estadístico utilizando Stata 6.0. RESULTADOS La media de edad de la madre fue de 24.82 años y del producto de 37.78 semanas de gestación. El promedio de peso del producto fue de 2,760 gramos. Los factores asociados a mortalidad perinatal fueron: ocupación del padre agricultor (RM ajustada 3,31; IC 95% 1,26-8,66; índice de riesgo obstétrico alto (RM ajustada 10,57; IC 95% 2,82-39,66, antecedente de cesárea (RM ajustada 2,75; IC 95% 1,37-5,51; cinco y más consultas prenatales (RM ajustada 4,43; IC 95% 1.86-10,54; producto pretérmino (RM ajustada 9,20; IC 95% 4,39-19,25. CONCLUSIONES: Los resultados muestran que es necesario implementar medidas de prevención y control que aseguren la identificación del riesgo en las mujeres embarazadas, con el fin de abatir la incidencia de mortalidad perinatal.

  9. Hipertrofia ventricular e mortalidade cardiovascular em pacientes de hemodiálise de baixo nível educacional

    Directory of Open Access Journals (Sweden)

    Rosana dos Santos e Silva Martin

    2012-01-01

    Full Text Available FUNDAMENTO: A hipertrofia ventricular esquerda é potente preditor de mortalidade em renais crônicos. Estudo prévio de nosso grupo mostrou que renais crônicos com menor escolaridade têm hipertrofia ventricular mais intensa. OBJETIVO: Ampliar estudo prévio e verificar se a hipertrofia ventricular esquerda pode justificar a associação entre escolaridade e mortalidade cardiovascular de pacientes em hemodiálise. MÉTODOS: Foram avaliados 113 pacientes entre janeiro de 2005 e março de 2008 e seguidos até outubro de 2010. Foram traçadas curvas de sobrevida comparando a mortalidade cardiovascular, e por todas as causas dos pacientes com escolaridade de até três anos (mediana da escolaridade e pacientes com escolaridade igual ou superior a quatro anos. Foram construídos modelos múltiplos de Cox ajustados para as variáveis de confusão. RESULTADOS: Observou-se associação entre nível de escolaridade e hipertrofia ventricular. A diferença estatística de mortalidade de origem cardiovascular e por todas as causas entre os diferentes níveis de escolaridade ocorreu aos cinco anos e meio de seguimento. No modelo de Cox, a hipertrofia ventricular e a proteína-C reativa associaram-se à mortalidade por todas as causas e de origem cardiovascular. A etiologia da insuficiência renal associou-se à mortalidade por todas as causas e a creatinina associou-se à mortalidade de origem cardiovascular. A associação entre escolaridade e mortalidade perdeu significância estatística no modelo ajustado. CONCLUSÃO: Os resultados do presente trabalho confirmam estudo prévio e demonstram, ademais, que a maior mortalidade cardiovascular observada nos pacientes com menor escolaridade pôde ser explicada por fatores de risco de ordem bioquímica e de morfologia cardíaca.

  10. Diversidad y alimentación hospitalaria: Diseño de un cuestionario de valoración de la adaptación cultural Diversity and Diet in Hospital: Design of a Questionnaire on Assessment of Cultural Adaptation

    OpenAIRE

    María Dolores Cano-Caballero Gálvez; María Martínez Pozo; María Angustias Lazuen Alcón; Guillermina Urbano García

    2008-01-01

    Una realidad actual es el aumento de la población inmigrante en los hospitales y por tanto las enfermeras debemos adaptar los cuidados a las necesidades de la población que atendemos. Objetivos: Conocer las posibilidades de introducir metodología participativa para abordar problemas de carácter socio-sanitario, dentro de la institución hospitalaria. Determinar la capacidad de las Unidades de Enfermería hospitalaria para introducir cuidados culturalmente adaptados. Diseñar e introducir en los ...

  11. Mortalidade em idosos por diabetes mellitus como causa básica e associada

    Directory of Open Access Journals (Sweden)

    Cláudia Medina Coeli

    2002-04-01

    Full Text Available OBJETIVO:Analisar a mortalidade por diabetes mellitus em idosos e a subenumeração do diabetes como causa do óbito de acordo com estatísticas baseadas unicamente em causa básica de óbito. MÉTODOS:Foram revisadas todas as 2.974 declarações de óbito ocorridas em 1994 de idosos residentes em um núcleo habitacional localizado na cidade do Rio de Janeiro, RJ. Destas, foram estudados 291 óbitos, tendo o diabetes mellitus como causa básica (150 e associada (141. A proporção de óbitos em que a diabetes aparece como causa básica em relação ao total de óbitos por diabetes foi calculada de forma global e segundo sexo e faixa etária. RESULTADOS:Dos 291 óbitos estudados, 138 (47,4% ocorreram em homens, e 153, em mulheres (52,6%. As taxas de mortalidade apresentaram crescimento contínuo com o avançar da idade, sendo superiores no sexo masculino, embora a diferença entre sexos tenha sido menor para a análise baseada unicamente na causa básica. Observou-se proporção elevada de óbitos domiciliares (22%. A proporção de óbitos por diabetes como causa básica foi de 51,5%, sendo maior nas mulheres do que nos homens. CONCLUSÕES:A análise das estatísticas de mortalidade baseadas unicamente na causa básica do óbito pode levar a perfis distorcidos, em função da subenumeração não ocorrer aleatoriamente. Estudos adicionais em coortes de idosos brasileiros diabéticos são necessários para permitir uma avaliação mais acurada da mortalidade nesse grupo.

  12. Factores de riesgo relacionados con la mortalidad por traumatismo Craneoencefálico Severo

    OpenAIRE

    Andrés Andrés Matos; Carlos A. Vázquez Torres; Karel Romero Vallejo

    2011-01-01

    Presenta un estudio descriptivo en pacientes ingresados en la Unidad de Cuidados Intensivos Pediátricos con trauma craneoencefálico severo, durante el periodo comprendido entre los años 2008-2010, con el objetivo de analizar los factores de riesgo relacionados con la mortalidad por esa causa. La edad más representada fue la comprendida entre los 11-15 años (56.90%), los pacientes incluidos en el grupo de 1-5 años resultaron más vulnerables al desarrollo de complicaciones médicas. Las fractura...

  13. Patrón de mortalidad de la población española

    OpenAIRE

    Ramiro Fariñas, Diego; Pujol Rodríguez, Rogelio; Abellán García, Antonio

    2016-01-01

    Enfermedades del sistema circulatorio, tumores y enfermedades respiratorias son las tres causas más importantes de muerte. Son responsables de siete de cada diez muertes de personas mayores y se mantiene esta tendencia en los últimos años.El patrón de mortalidad por edad y causa visualiza cómo afecta a cada estrato demográfico cada tipo de muerte. En los niños predominan otras causas (relacionadas con malformaciones, y afecciones en período perinatal); en los jóvenes, causas externas (acciden...

  14. Mortalidad en varones jóvenes de México

    Directory of Open Access Journals (Sweden)

    Esperanza Tuñón Pablos

    2005-01-01

    Full Text Available En este artículo se analizan las principales causas de mortalidad entre los varones jóvenes de México, a saber: los accidentes, homicidios y suicidios, a la luz de la perspectiva de género. Este enfoque permite mostrar el peso del modelo hegemónico de masculinidad en las prácticas de riesgo que conducen hacia estas causas y cuestionar la socialización de género como un proceso desencadenante de riesgo para la relación de los varones con las mujeres y consigo mismos.

  15. Tendência da mortalidade neonatal na cidade de Salvador (Bahia-Brasil, 1996-2012

    Directory of Open Access Journals (Sweden)

    Annelise C. Gonçalves

    2015-09-01

    Full Text Available Objetivos:analisar a tendência da mortalidade neonatal, principais causas e potenciais fatores de risco, em Salvador-Bahia, 1996-2012.Métodos:estudo de série temporal tendo como fontes de dados os Sistemas de Informação sobre Mortalidade e sobre Nascidos Vivos/NV e Cadastro Nacional de Estabelecimentos de Saúde. Parâmetros da tendência temporal do coeficiente de mortalidade neonatal/CMN e da proporção de NV segundo características maternas, do recém-nascido e de atenção à saúde foram obtidos mediante Regressão Linear Simples. Coeficiente de Correlação de Spearman avaliou relação entre estas variáveis.Resultados:observou-se declínio de 21,2% no CMN, principalmente devido ao componente precoce (β= - 0,730; p=0,006; R2= 0,423. Acompanhou esta tendência, a proporção de NV de mães adolescentes e sem instrução. A proporção de NV de mães com idade > 35 anos, nascimentos prematuros e de partos cesáreos exibiram crescimento. Predominaram mortes neonatais por Infecções específicas do período perinatal (13,2%, Hipóxia intrauterina/Asfixia ao nascer (8,4% e Transtornos relacionados à prematuridade/baixo peso ao nascer (15,9%, estas últimas com tendência de crescimento (β= 1,319; p=0,006; R2= 0,428.Conclusões:a mortalidade neonatal e potenciais fatores de risco estão decrescendo em Salvador. Iniciativas voltadas para melhoria da atenção ao recém-nascido e das condições de vida da população podem estar contribuindo para esta tendência.

  16. Intervalo entre o Nascimento de Gêmeos: Morbidade e Mortalidade do Segundo Gemelar

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    Fava Jair Luiz

    2001-01-01

    Full Text Available Objetivo: avaliar o efeito do intervalo de tempo entre o nascimento de gêmeos sobre a morbidade e a mortalidade neonatal do segundo gemelar. Métodos: realizamos um estudo retrospectivo em 50 gemelíparas atendidas na Maternidade Pró-Matre de Vitória que pariram 100 recém-natos vivos, por via vaginal, com peso superior a 500 g e sem malformações maiores. Separamos os recém-natos em G1 (primeiro gêmeo e G2 (segundo gêmeo. Foram considerados como indicativos de morbidade neonatal: asfixia ao nascimento, caracterizada pelo índice de Apgar inferior a 7, no 1º minuto de vida; síndrome do desconforto respiratório, apurada à luz de dados clínicos e radiológicos, e tempo de internação hospitalar superior a 4 dias. Foi analisada também a mortalidade intra-hospitalar. Quanto ao estudo do intervalo de tempo de parturição entre os gêmeos (deltat, realizamos pontos de corte de 5 em 5 minutos, até 35 minutos. Fizemos, também, análise por faixas de tempo: deltat até 5 minutos, de 6 a 10, de 11 a 15, de 16 a 20 e de 21 a 150 minutos. Resultados: não houve diferença estatisticamente significante (p<0,05 entre a morbidade/mortalidade do segundo gêmeo em relação ao primeiro, considerando os níveis de cortes e faixas de tempo referidos. Conclusão: o intervalo de tempo de parturição entre G1 e G2 não influenciou a morbidade e mortalidade do segundo gemelar, impondo-se, contudo, na assistência à parturição do segundo gemelar, individualizar as particularidades de cada caso, não contemplando a ansiedade por meio de procedimentos intempestivos e potencialmente danosos.

  17. Análisis factorial para el estudio de la mortalidad de Costa Rica. Periodo 1900-2010

    Directory of Open Access Journals (Sweden)

    Eduardo Aguilar Fernández

    2013-01-01

    Full Text Available La mortalidad es uno de los componentes de la dinámica demográfica constituido en un importante indicador del reflejo del estado de salud de una población, por lo que conocer su comportamiento es de suma importancia en el desarrollo de las sociedades. El objetivo de la presente investigación es construir un modelo de análisis factorial mediante la aplicación de la técnica de componentes principales a un conjunto de tasas de mortalidad por grupo de edad y sexo para identificar componentes influyentes en la mortalidad de Costa Rica durante el período 1900-2010. El análisis factorial permitió identificar inicialmente tres factores principales que explican en un 96,6 % la variabilidad de la mortalidad de Costa Rica. Se espera que esta serie de estimaciones contribuyan al estudio del comportamiento de la mortalidad y de sus implicaciones para el desarrollo del país y, a su vez, sirva de base para que futuros estudios complementen los alcances de la presente investigación.

  18. Psychosocial factors affecting medication adherence among HIV-1 infected adults receiving combination antiretroviral therapy (cART) in Botswana.

    Science.gov (United States)

    Do, Natalie T; Phiri, Kelesitse; Bussmann, Hermann; Gaolathe, Tendani; Marlink, Richard G; Wester, C William

    2010-06-01

    As increasing numbers of persons are placed on potentially life-saving combination antiretroviral therapy (cART) in sub-Saharan Africa, it is imperative to identify the psychosocial and social factors that may influence antiretroviral (ARV) medication adherence. Using an 87 question survey, the following data were collected from patients on cART in Botswana: demographics, performance (Karnofsky) score, perceived stigma and level of HIV disclosure, attitudes and beliefs concerning HIV/AIDS, substance and/or drug use, depression, and pharmacy and healthcare provider-related factors. Overall adherence rates were determined by patient self-report, institutional adherence, and a culturally modified Morisky scale. Three hundred adult patients were recruited between April and May 2005. The overall cART adherence rate was 81.3% based on 4 day and 1 month patient recall and on clinic attendance for ARV medication refills during the previous 3 months. Adults receiving cART for 1-6 months were the least adherent (77%) followed by those receiving cART for greater than 12 months (79%). Alcohol use, depression, and nondisclosure of positive HIV status to their partner were predictive of poor adherence rates (p value HIV disclosure to "at-risk" partners and provide ongoing counseling and education to help patients recognize and overcome HIV-associated stigma, alcohol abuse, and depression.

  19. Salmonella collected from nest run cart shelves in commercial shell egg processing facilities.

    Science.gov (United States)

    Musgrove, M T; Shaw, J D; Harrison, M A

    2012-09-01

    Salmonella, a member of the bacterial family Enterobacteriaceae, may be recovered from foods and processing facilities. High levels of Enterobacteriaceae in the processing plant environment can be an indication of inadequate sanitation. This experiment was designed to determine if nest run egg carts serve as reservoirs for Salmonella. Eggs that are produced by hens not housed in buildings connected to the processing plant are referred to as nest run. Many of these eggs are transported to a central processing facility before they are washed, graded, and packed. Two plants in the Southeastern United States were sampled; one was a mixed operation and the other was an off-line operation. On each of 3 visits, 5 shelves on each of 5 carts were sampled (n = 25/visit). A 12 × 12 cm area on each shelf was swabbed with a sterile gauze pad moistened with PBS and transported on ice back to the laboratory. Each swab was preenriched in buffered peptone at 37°C for 24 h, selectively enriched using TT and Rappaport-Vassiliadis broth at 42°C overnight, then plated onto brilliant green sulfa and XLT-4 incubated at 37°C for 24 h. Presumptive colonies were transferred to lysine iron agar and triple sugar iron slants for 24 h at 37°C. Isolates with presumptive reactions were confirmed using commercial polyclonal antisera. After initial confirmation, serogrouping was performed using commercial antisera. Mixed-operation swab samples were 12% positive for Salmonella, whereas off-line samples were 36% positive for Salmonella; isolates were confirmed as serogroups B, C1, and C2. Kauffman-White serotyping was performed by a contract laboratory. Serotypes (n = 30) recovered were Anatum, Heidelberg, Infantis, Kentucky, Mbandanka, and Typhimurium. This work demonstrated that nest run egg carts may serve as reservoirs for Salmonella in the shell egg processing environment.

  20. Liver Fibrosis in HIV Patients Receiving a Modern cART

    Science.gov (United States)

    Mohr, Raphael; Schierwagen, Robert; Schwarze-Zander, Carolynne; Boesecke, Christoph; Wasmuth, Jan-Christian; Trebicka, Jonel; Rockstroh, Jürgen Kurt

    2015-01-01

    Abstract Liver-related death in human immunodeficiency virus (HIV)-infected individuals is about 10 times higher compared with the general population, and the prevalence of significant liver fibrosis in those with HIV approaches 15%. The present study aimed to assess risk factors for development of hepatic fibrosis in HIV patients receiving a modern combination anti-retroviral therapy (cART). This cross-sectional prospective study included 432 HIV patients, of which 68 (16%) patients were anti-hepatitis C virus (HCV) positive and 23 (5%) were HBsAg positive. Health trajectory including clinical characteristics and liver fibrosis stage assessed by transient elastography were collected at inclusion. Liver stiffness values >7.1 kPa were considered as significant fibrosis, while values >12.5 kPa were defined as severe fibrosis. Logistic regression and Cox regression uni- and multivariate analyses were performed to identify independent factors associated with liver fibrosis. Significant liver fibrosis was detected in 10% of HIV mono-infected, in 37% of HCV co-infected patients, and in 18% of hepatitis B virus co-infected patients. The presence of diabetes mellitus (odds ratio [OR] = 4.6) and FIB4 score (OR = 2.4) were independently associated with presence of significant fibrosis in the whole cohort. Similarly, diabetes mellitus (OR = 5.4), adiposity (OR = 4.6), and the FIB4 score (OR = 3.3) were independently associated with significant fibrosis in HIV mono-infected patients. Importantly, cumulative cART duration protected, whereas persistent HIV viral replication promoted the development of significant liver fibrosis along the duration of HIV infection. Our findings strongly indicate that besides known risk factors like metabolic disorders, HIV may also have a direct effect on fibrogenesis. Successful cART leading to complete suppression of HIV replication might protect from development of liver fibrosis. PMID:26683921

  1. Cocaine- and amphetamine-regulated transcript peptide (CART) in the brain of zebra finch, Taeniopygia guttata: Organization, interaction with neuropeptide Y, and response to changes in energy status.

    Science.gov (United States)

    Singh, Omprakash; Kumar, Santosh; Singh, Uday; Kumar, Vinod; Lechan, Ronald M; Singru, Praful S

    2016-10-15

    Cocaine- and amphetamine-regulated transcript (CART) has emerged as a potent anorectic agent. CART is widely distributed in the brain of mammals, amphibians, and teleosts, but the relevant information in avian brain is not available. In birds, CART inhibits food intake, whereas neuropeptide Y (NPY), a well-known orexigenic peptide, stimulates it. How these neuropeptides interact in the brain to regulate energy balance is not known. We studied the distribution of CART-immunoreactivity in the brain of zebra finch, Taeniopygia guttata, its interaction with NPY, and their response to dynamic energy states. CART-immunoreactive fibers were found in the subpallium, hypothalamus, midbrain, and brainstem. Conspicuous CART-immunoreactive cells were observed in the bed nucleus of the stria terminalis, hypothalamic paraventricular, supraoptic, dorsomedial, infundibular (IN), lateral hypothalamic, Edinger-Westphal, and parabrachial nuclei. Hypothalamic sections of fed, fasted, and refed animals were immunostained with cFos, NPY, and CART antisera. Fasting dramatically increased cFos- and NPY-immunoreactivity in the IN, followed by rapid reduction by 2 hours and restoration to normal fed levels 6-10 hours after refeeding. CART-immunoreactive fibers in IN showed a significant reduction during fasting and upregulation with refeeding. Within the IN, double immunofluorescence revealed that 94 ± 2.1% of NPY-immunoreactive neurons were contacted by CART-immunoreactive fibers and 96 ± 2.8% NPY-immunoreactive neurons expressed cFos during fasting. Compared to controls, superfused hypothalamic slices of fasted birds treated with CART-peptide showed a significant reduction (P CART in the brain of T. guttata may perform several functions, and has a particularly important role in the hypothalamic regulation of energy homeostasis. J. Comp. Neurol. 524:3014-3041, 2016. © 2016 Wiley Periodicals, Inc.

  2. Evaluación de la respuesta educativa al alumnado de aulas hospitalarias en la provincia de Almería

    Directory of Open Access Journals (Sweden)

    Antonio Sánchez Palomino

    2016-06-01

    Full Text Available Con esta investigación, que forma parte de una tesis doctoral en proceso, pretendemos evaluar la respuesta educativa ofrecida al alumnado de las aulas hospitalarias ubicadas en la provincia de Almería (Complejo Hospitalario de Torrecárdenas, Hospital del Poniente y Hospital La Inmaculada. Para ello, hemos utilizado como grupos informantes a los tres colectivos presentes, alumnado, familiares y personal médico-sanitario.Utilizamos como técnica de recogida de información el sistema de encuestas y, como instrumento, los cuestionarios tipo Likert con respuesta múltiple cerrada, cuyos datos han sido posteriormente analizados mediante SPSS.Los resultados obtenidos muestran que se encuentran satisfechos con la respuesta educativa, no sólo en los aspectos curriculares y educativos, sino también con los distintos programas educativos de carácter lúdico que desarrollan los docentes. De otra parte, se confirma la necesidad de implementar programas de formación específica dirigidos al personal médico-sanitario, pues muestran una actitud pasiva y desinteresada hacia el aula hospitalaria.

  3. Educación inclusiva en contextos inéditos: La implementación de la Pedagogía Hospitalaria

    Directory of Open Access Journals (Sweden)

    Ascensión Palomares-Ruiz

    2016-01-01

    Full Text Available El objetivo de este trabajo es analizar los beneficios de la Pedagogía Hospitalaria en las Unidades de Salud Mental que reciben pacientes en edad escolar que permanecen largos períodos ingresados. Esto los aparta del sistema escolar ordinario. Esta investigación la hemos desarrollado durante diez años con una metodología mixta. En la contextualización del marco teórico, estudiamos la evolución de esta disciplina y los factores que intervienen. Destacamos que el alumnado valora positivamente superar su curso académico con éxito, la enseñanza personalizada de los docentes del Aula Hospitalaria, y la posibilidad de evadirse del medio hospitalario. Estas conclusiones demandan una mayor implicación y formación del profesorado para un trabajo coordinado, y el uso de las TIC en conexión con los centros educativos, para propiciar una educación inclusiva.

  4. Ensayo de resistencia a la compresión de cartón ondulado

    OpenAIRE

    García Bol, Ana María

    2013-01-01

    Por medio de este trabajo se puede observar la importancia de un sistema de calidad en la empresa. Los ensayos de ECT realizados en el laboratorio pretenden cumplir los requisitos propios y del cliente, siendo esto básico y asociado al concepto de calidad, no sólo en la industria del cartón ondulado sino en todas las restantes. Hemos visto todo el proceso productivo, ensayos, resultados mediante control estadístico, además de realizar ensayos de gramaje, comentar la trazabilidad y la política...

  5. Orchard spatial information extraction from SPOT-5 image based on CART model

    Science.gov (United States)

    Li, Deyi; Zhang, Shuwen

    2009-07-01

    Orchard is an important agricultural industry and typical land use type in Shandong peninsula of China. This article focused on the automatic information extraction of orchard using SPOT-5 image. After analyzing every object's spectrum, we proposed a CART model based on sub-region and hierarchy theory by exploring spectrum, texture and topography attributes. The whole area was divided into coastal plain region and hill region based on SRTM data and extracted respectively. The accuracy reached to 86.40%, which was much higher than supervised classification method.

  6. Loading of carts in barges at HHM, Shanghai, beginning December 2000.

    CERN Multimedia

    F. Feyzi

    2000-01-01

    End of manufacture of encap carts at HHM in Shanghai. HHM has done an excellent job in manufacturing these parts with high quality and on time. HHM Vice General Manager Mr. Zhao Cheng Xiang hosted an excellent farewell dinner for F. Feyzi and J. Wollert on December 1 where all colleagues from HHM who have worked with us over the past two years were present. Each person played a key role in the success of the project and F. Feyzi thanked them individually on behalf of CMS.

  7. Putting the horse before the cart: a pragmatist analysis of knowledge

    Directory of Open Access Journals (Sweden)

    Luís M. Augusto

    2011-01-01

    Full Text Available The definition of knowledge as justified true belief is the best we presently have. However, the canonical tripartite analysis of knowledge does not do justice to it due to a Platonic conception of a priori truth that puts the cart before the horse. Within a pragmatic approach, I argue that by doing away with a priori truth, namely by submitting truth to justification, and by accordingly altering the canonical analysis of knowledge, this is a fruitful definition. So fruitful indeed that it renders the Gettier counterexamples vacuous, allowing positive work in epistemology and related disciplines.

  8. La carte, ça sert d'abord à enseigner la géographie

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    Jean-François Joly

    1999-12-01

    Full Text Available L'introduction d'un exercice de cartographie au baccalauréat fournit l'occasion de réfléchir aux méthodes et aux stratégies pédagogiques qu'il convient de mettre en œuvre afin de préparer efficacement les élèves. C'est surtout l'occasion de rappeler qu'il n'y a pas de géographie sans carte.

  9. Diagnósticos al alta hospitalaria de las personas inmigrantes en la ciudad de Valencia (2001-2002

    Directory of Open Access Journals (Sweden)

    Antonio Salazar

    2003-01-01

    Full Text Available Fundamento:La inmigración en España se ha incrementado de forma notable en la última década. Por razones teóricas se ha planteado que esta población pudiera ser responsable de un aumento de la incidencia y/o transmisión de enfermedades infecciosas. Sin embargo, existen escasos estudios acerca de las enfermedades de este colectivo que permitan conocer la importancia de esta afirmación. El objetivo de este estudio es cuantificar la atención hospitalaria a esta población en la ciudad de Valencia. Métodos: Se obtuvieron los registros de altas de los Servicios de Admisión de los hospitales públicos de la ciudad de Valencia. Se desarrolló un estudio observacional retrospectivo para el año comprendido entre el 1 de octubre de 2001 al 30 de septiembre del 2002. Resultados: Recuperamos 8.444 ingresos que identificaron 1.577 ingresos de inmigrantes. Se evidenció una proporción similar de inmigrantes registrados con documentación reglada (841, 51,16% e inmigrantes supuestamente no regularizados (803, 48,84%. Predominaron las mujeres (68,3% frente a los varones (31,7% y una media de edad inferior a los 30 años. El diagnóstico de alta más frecuente fue «complicaciones del embarazo, parto y puerperio» con 37,7% del total. Los «traumatismos y envenenamientos », «enfermedades del aparato digestivo» y «enfermedades del aparato respiratorio» representaron el 12,9%, el 7,8% y el 5,4%, respectivamente. Las «enfermedades infecciosas y parasitarias» supusieron el 4,4%. Conclusiones: La proporción de enfermedades infecciosas e infectocontagiosas observadas no contribuyen a alentar las opiniones difundidas sobre importación o reemergencia de enfermedades desde los colectivos de inmigrantes. La inmigración masiva acaecida requiere múltiples adaptaciones del Sistema de Salud que permitan establecer el perfil de salud de este colectivo, basado en estimaciones poblacionales.

  10. Diagnósticos al alta hospitalaria de las personas inmigrantes en la ciudad de Valencia (2001-2002

    Directory of Open Access Journals (Sweden)

    Salazar Antonio

    2003-01-01

    Full Text Available Fundamento: La inmigración en España se ha incrementado de forma notable en la última década. Por razones teóricas se ha planteado que esta población pudiera ser responsable de un aumento de la incidencia y/o transmisión de enfermedades infecciosas. Sin embargo, existen escasos estudios acerca de las enfermedades de este colectivo que permitan conocer la importancia de esta afirmación. El objetivo de este estudio es cuantificar la atención hospitalaria a esta población en la ciudad de Valencia. Métodos: Se obtuvieron los registros de altas de los Servicios de Admisión de los hospitales públicos de la ciudad de Valencia. Se desarrolló un estudio observacional retrospectivo para el año comprendido entre el 1 de octubre de 2001 al 30 de septiembre del 2002. Resultados: Recuperamos 8.444 ingresos que identificaron 1.577 ingresos de inmigrantes. Se evidenció una proporción similar de inmigrantes registrados con documentación reglada (841, 51,16% e inmigrantes supuestamente no regularizados (803, 48,84%. Predominaron las mujeres (68,3% frente a los varones (31,7% y una media de edad inferior a los 30 años. El diagnóstico de alta más frecuente fue «complicaciones del embarazo, parto y puerperio» con 37,7% del total. Los «traumatismos y envenenamientos», «enfermedades del aparato digestivo» y «enfermedades del aparato respiratorio» representaron el 12,9%, el 7,8% y el 5,4%, respectivamente. Las «enfermedades infecciosas y parasitarias» supusieron el 4,4%. Conclusiones: La proporción de enfermedades infecciosas e infecto-contagiosas observadas no contribuyen a alentar las opiniones difundidas sobre importación o reemergencia de enfermedades desde los colectivos de inmigrantes. La inmigración masiva acaecida requiere múltiples adaptaciones del Sistema de Salud que permitan establecer el perfil de salud de este colectivo, basado en estimaciones poblacionales.

  11. Necesidades de formación psicopedagógica de pediatras en la atención hospitalaria

    Directory of Open Access Journals (Sweden)

    Sebastià Verger-Gelabert

    2015-10-01

    Full Text Available Antecedentes. La enfermedad crónica infantil tiene impacto en la familia y afecta al paciente física, psicoemocional y socialmente. La hipótesis de este estudio es que la identificación de tales factores puede servir para mejorar su formación y competencia comunicativa y, consecuentemente, la gestión de la enfermedad crónica. Objetivo. Identificar las necesidades formativas psicopedagógicas en pediatras y residentes en pediatría del mayor hospital público en las Islas Baleares, España. Materiales y métodos. Estudio de diseño mixto cuantitativo-cualitativo, donde 51 pediatras y residentes -71.8% del servicio- contestaron un cuestionario y 26 participaron en entrevistas analizadas con análisis de contenido. Resultados. Los pediatras consideran que el apoyo y la cohesión familiar son los factores más relevantes para gestionar adecuadamente una enfermedad crónica infantil, pero manifiestan tener escasos conocimientos sobre el desarrollo emocional y psicológico de los niños y adolescentes. Destacan la escasa comunicación entre pediatras y escuela, así como la deficiente información sobre servicios socioeducativos que se ofrecen en el hospital y también en la comunidad. Los resultados cualitativos fueron organizados en cinco bloques temáticos: impacto de la enfermedad crónica infantil en la familia, formación psicopedagógica de los pediatras, dificultades en la práctica, comunicación entre escuela y hospital y el hospital como entidad educativa. Conclusión. La pediatría hospitalaria requiere considerar las específicas necesidades psicoemocionales de la familia y del menor, para lo cual se necesita formación psicopedagógica, así como un trabajo interprofesional entre sanitarios y educadores.

  12. Mortalidad por causa externas: un problema de salud pública. Argentina, Chile y Colombia. 2000-2008

    Directory of Open Access Journals (Sweden)

    Doris Cardona Arango

    2013-01-01

    Full Text Available Se realizó un estudio descriptivo de la mortalidad por causas externas en la población argentina, chilena y colombiana durante el período 2000-2008. Se analizaron las muertes por homicidios, suicidios y accidentes de tránsito, en función de la edad y sexo. Se observó una reducción del riesgo de morir por estas causas en el segundo trienio. Hubo diferencias en la mortalidad por sexo y edad dependiendo la causa externa de muerte. Los mayores niveles de mortalidad correspondieron a los homicidios, seguidos por los accidentes de tránsito y por último los suicidios. Se registró sobremortalidad masculina en los tres países seleccionados.

  13. Mortalidade infantil por causas evitáveis em uma cidade do Nordeste do Brasil

    Directory of Open Access Journals (Sweden)

    Suelayne Gonçalves do Nascimento

    2014-04-01

    Full Text Available Estudo de corte transversal que objetivou descrever a ocorrência da mortalidade infantil em Recife (PE entre 2000 e 2009, segundo causas evitáveis. A população foi composta pelos óbitos infantis de mães residentes na cidade do Recife e a classificação de evitabilidade adotou a Lista de causas de mortes evitáveis por intervenções do Sistema Único de Saúde. Para análise dos dados utilizou-se estatística descritiva. Foi observado decréscimo no coeficiente de mortalidade infantil de 20,4 para 12,1 por 1.000 nascidos vivos. Do total de 3.743 óbitos registrados, 2.861 (76,4% foram classificados como evitáveis. Destacaram-se os óbitos reduzíveis por adequada atenção à mulher na gestação. A abordagem da evitabilidade auxilia nas discussões relacionadas à organização, qualidade e acesso aos serviços de saúde, bem como na identificação dos óbitos que poderiam ter sido prevenidos ou evitados por uma adequada atenção à saúde materno-infantil.

  14. Tendencias de mortalidad por cánceres atribuibles al tabaco en México

    Directory of Open Access Journals (Sweden)

    Víctor José Tovar-Guzmán

    2002-01-01

    Full Text Available Objetivo. Describir la tendencia de la mortalidad por cáncer atribuible al consumo de tabaco, particularmente neoplasias del pulmón, en México, durante el periodo 1980-1997. Material y métodos. Se hizo un análisis de tendencias de mortalidad para cada tipo de cáncer asociado con el tabaco, según la Clasificación Internacional de Enfermedades. Las tasas cruda y ajustada de mortalidad fueron estimadas en términos de edad, género, causa básica de la muerte y año, entre 1980 y 1997. Se estimó la razón de género y proporción relativa para los casos que estaban en el grupo de edad entre 35 y 64 años y para toda la población estudiada. Como denominador se utilizaron las proyecciones por edad calculadas por el Consejo Nacional de Población (1970-2010. Resultados. La razón de género para las tasas de mortalidad por cáncer de laringe, esófago, cavidad oral y faringe fue de 2.10:1.00 (hombre: mujer. La razón de género para el cáncer de laringe es enorme: 4.21: 1.00, probablemente debida a la mayor prevalencia de hombres fumadores de tabaco. La proporción relativa estimada, usando la mortalidad total debida a tumores malignos, entre 1980 y 1997 fue la siguiente: cáncer de pulmón 12.31%, laringe 1.71%, esófago 1.55% y cavidad oral/faringe 1.49%. El antecedente de tabaquismo tiene correlación con la tendencia de la tasa de mortalidad por cáncer del pulmón (Beta: 0.910, IC 95%: 1.097-1.797; R² 0.827. Para los grupos sociales mas pobres, por entidad federativa, la correlación está invertida (Beta: -0.510, IC 95%: -0.170, -0.039, R²: 0.260. Conclusiones. En México, la mejoría en el diagnóstico, la transición demográfica y el incremento del consumo de tabaco son, probablemente, los principales factores a los que se atribuye la tasa de mortalidad por cáncer. No obstante, otras variables asociadas con el estilo de vida, como urbanización, actividad física, ingesta de carotenoides y otros componentes dietéticos y t

  15. Comparison of single and boosted protease inhibitor versus nonnucleoside reverse transcriptase inhibitor-containing cART regimens in antiretroviral-naïve patients starting cART after January 1, 2000

    DEFF Research Database (Denmark)

    Mocroft, A; Horban, A; Clumeck, N

    2006-01-01

    increase) response in antiretroviral-naïve patients starting either a single protease inhibitor (PI; n = 183), a ritonavir-boosted PI regimen (n = 197), or a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based cART regimen (n = 447) after January 1, 2000, and the odds of lack of virologic...... or immunologic response at 3 years after starting cART. METHOD: Cox proportional hazards models and logistic regression. RESULTS: After adjustment, compared to patients taking an NNRTI-regimen, patients taking a single-PI regimen were significantly less likely to achieve a viral load (VL)

  16. Análisis del impacto de la mortalidad por suicidios en México, 2000-2012

    Directory of Open Access Journals (Sweden)

    Claudio Alberto Dávila Cervantes

    2015-01-01

    Full Text Available El objetivo del presente artículo es analizar la carga de la mortalidad por suicidios en México, a partir del indicador de años de vida perdidos (AVP, entre 2000 y 2012, por sexo, grupos de edad (para menores de 85 años de edad a nivel nacional y por entidad federativa. Se emplearon estadísticas vitales de mortalidad y estimaciones de población para calcular tasas estandarizadas de mortalidad y los años de vida perdidos por suicidios. Entre 2000 y 2012 se dio un incremento sostenido de la tasa de mortalidad por suicidios. En hombres, el grupo de edad con las mayores tasas fue el de 85 años y más; para mujeres el de 15-19 años. El mayor impacto en la esperanza de vida se dio entre los 20 y 24 años en hombres y entre los 15 y 19 años para mujeres. Los estados con la mayor mortalidad se ubican en la península de Yucatán (Yucatán, Quintana Roo y Campeche. La mortalidad por suicidio en México se ha incrementado de manera constante. Los suicidios son prevenibles, por lo que es fundamental implementar políticas públicas en salud a través de acciones de identificación oportuna, estrategias integrales de prevención y el estudio detallado de los factores de riesgo asociados.

  17. Mortalidade perinatal em duas coortes de base populacional no Sul do Brasil: tendências e diferenciais

    Directory of Open Access Journals (Sweden)

    Ana M. B. Menezes

    Full Text Available A evolução da mortalidade perinatal foi estudada em Pelotas, Rio Grande do Sul, através de dois estudos de coorte realizados em 1982 e 1993. Todos os nascimentos hospitalares e os óbitos foram monitorizados com visitas diárias aos hospitais. A causa da morte foi determinada através de informações do prontuário, entrevista com o pediatra e de necrópsias. O coeficiente de mortalidade perinatal sofreu uma redução de 31% na década. O sub-registro que era de 42,1% em 1982, foi de apenas 6,8% em 1993. Dentre as causas de mortalidade perinatal, houve uma redução em 1993 de 58% para óbitos fetais antepartum, 47% para imaturidade e 62% para outras causas. Os coeficientes para asfixia sofreram um aumento de 4,5/1.000 para 8,3/1.000. As meninas apresentaram um coeficiente de mortalidade perinatal menor do que os meninos. Os coeficientes de mortalidade perinatal conforme peso ao nascer e renda familiar sofreram importantes reduções, sendo que a mais notável foi para crianças de baixo peso e de famílias de renda alta, com uma queda de 68%. Assim como em 1982, os recém-nascidos pré-termo tiveram coeficientes três vezes mais elevados do que crianças pequenas para a idade gestacional. Apesar da queda dos índices de mortalidade na década, as diferenças entre os grupos sociais mantiveram-se grandes.

  18. Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND

    Directory of Open Access Journals (Sweden)

    Ana B. Sanchez

    2017-02-01

    Full Text Available Multiple mechanisms appear to contribute to neuronal stress and injury underlying HIV-associated neurocognitive disorders (HAND, which occur despite the successful introduction of combination antiretroviral therapy (cART. Evidence is accumulating that components of cART can itself be neurotoxic upon long-term exposure. In addition, abuse of psychostimulants, such as methamphetamine (METH, seems to compromise antiretroviral therapy and aggravate HAND. However, the combined effect of virus and recreational and therapeutic drugs on the brain is still incompletely understood. However, several lines of evidence suggest a shared critical role of oxidative stress, compromised neuronal energy homeostasis and autophagy in promotion and prevention of neuronal dysfunction associated with HIV-1 infection, cART and psychostimulant use. In this review, we present a synopsis of recent work related to neuronal stress and injury induced by HIV infection, antiretrovirals (ARVs and the highly addictive psychostimulant METH.

  19. Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND.

    Science.gov (United States)

    Sanchez, Ana B; Kaul, Marcus

    2017-02-23

    Multiple mechanisms appear to contribute to neuronal stress and injury underlying HIV-associated neurocognitive disorders (HAND), which occur despite the successful introduction of combination antiretroviral therapy (cART). Evidence is accumulating that components of cART can itself be neurotoxic upon long-term exposure. In addition, abuse of psychostimulants, such as methamphetamine (METH), seems to compromise antiretroviral therapy and aggravate HAND. However, the combined effect of virus and recreational and therapeutic drugs on the brain is still incompletely understood. However, several lines of evidence suggest a shared critical role of oxidative stress, compromised neuronal energy homeostasis and autophagy in promotion and prevention of neuronal dysfunction associated with HIV-1 infection, cART and psychostimulant use. In this review, we present a synopsis of recent work related to neuronal stress and injury induced by HIV infection, antiretrovirals (ARVs) and the highly addictive psychostimulant METH.

  20. Psychometric properties of the Belgian coach version of the coach-athlete relationship questionnaire (CART-Q).

    Science.gov (United States)

    Balduck, A-L; Jowett, S

    2010-10-01

    The study examined the psychometric properties of the Belgian coach version of the Coach-Athlete Relationship Questionnaire (CART-Q). The questionnaire includes three dimensions (Closeness, Commitment, and Complementarity) in a model that intends to measure the quality of the coach-athlete relationship. Belgian coaches (n=144) of athletes who performed at various competition levels in such sports as football, basketball, and volleyball responded to the CART-Q and to the Leadership Scale for Sport (LSS). A confirmatory factor analysis proved to be slightly more satisfactory for a three-order factor model, compared with a hierarchical first-order factor model. The three factors showed acceptable internal consistency scores. Moreover, functional associations between the three factors and coach leadership behaviors were found offering support to the instrument's concurrent validity. The findings support previous validation studies and verify the psychometric properties of the CART-Q applied to Belgian coaches of team sports.

  1. I - Análise dos dados de mortalidade I - Analysis of mortality data

    Directory of Open Access Journals (Sweden)

    Maria Helena Prado de Mello Jorge

    1997-08-01

    Full Text Available As mortes por causas externas correspondem a grande parcela de óbitos em, praticamente, todos os países do mundo, ocupando, sempre, a segunda ou terceira colocação. Porém a sua distribuição quanto ao tipo de causa é diversa. Com o objetivo de estudar a mortalidade por causas externas, segundo o tipo de causa, sexo e idade, foi descrita a situação dessas mortes no Brasil e capitais, no período 1977 a 1994. Foram calculados os coeficientes de mortalidade por causas externas e a mortalidade proporcional, utilizando os dados de mortalidade fornecidos pelo Sistema de Informação de Mortalidade do Ministério da Saúde, e a população foi estimada baseada nos dados censitários de 1970, 1980 e 1991. Os resultados mostraram que, em números absolutos, os óbitos por causas externas quase dobraram no período de 1977 a 1994, passando a ser a segunda causa de morte no País. O coeficiente de mortalidade, em 1994, foi de 69,8/100.000 habitantes e o maior crescimento se deu nos óbitos do sexo masculino. Os coeficientes de mortalidade masculinos são, aproximadamente, 4,5 vezes o valor dos femininos. As causas externas representaram a primeira causa de morte dos 5 aos 39 anos, sendo a maior ocorrência na faixa etária dos 15 a 19 anos (65% dos óbitos por causas externas. Além do aumento, parece estar ocorrendo um deslocamento das mortes para faixas etárias mais jovens. A mortalidade por causas externas, segundo tipo, mostra que durante o período analisado houve aumento tanto nos óbitos por acidentes de trânsito, quanto por homicídios, tendo os suicídios permanecido, praticamente, constantes. No grupo de acidentes classificados como "demais acidentes" houve leve aumento, devido, principalmente, às quedas e afogamentos. Nas capitais dos Estados a mortalidade por causas externas apresentam valores mais altos que a média brasileira, com exceção de algumas áreas do Nordeste. As capitais da região Norte apresentaram algumas das

  2. Factores de riesgo en la mortalidad de los recién nacidos de muy bajo peso con membrana hialina

    OpenAIRE

    García Arias, M.B.; Zuluaga Arias, Pilar; Arrabal Terán, M. C.; Arizcun Pineda, J.

    2005-01-01

    Introducción: La expectativa de vivir de los recién nacidos de muy bajo peso (RNMBP) ha mejorado en los últimos años. Cuando estos pacientes presentan, además, enfermedad de membrana hialina (EMH), es difícil conocer con seguridad cuáles son los factores que más influyen en su mortalidad. Este trabajo tiene el objetivo de averiguar, dentro de un conjunto de variables, las más influyentes en la mortalidad desde una perspectiva multifactorial. Pacientes y métodos: Se tomó una muestra de 209 RNM...

  3. Algunos factores de riesgo para mortalidad neonatal en un hospital de III nivel, Popayán.

    OpenAIRE

    Mario Delgado; Alejandro Muñoz; Leonora Orejuela; Carlos H. Sierra

    2009-01-01

    Introducción. En Colombia, la mortalidad neonatal aporta actualmente 57% de los decesos en el primer año de vida. Objetivo. Establecer los factores de riesgo para mortalidad en la Unidad de Cuidado Neonatal del Hospital Universitario San José, Popayán, Colombia, 1999-2001. Materiales y métodos. Los casos (n = 51) fueron aquellos neonatos (>1200g) que murieron en un período menor a 28 días a partir de su nacimiento en la Unidad. Los controles (n = 125) fueron aquellos neonatos (>1200g) dados d...

  4. Hipertrofia ventricular e mortalidade cardiovascular em pacientes de hemodiálise de baixo nível educacional

    OpenAIRE

    Rosana dos Santos e Silva Martin; Luis Cuadrado Martin; Roberto Jorge da Silva Franco; Pasqual Barretti; Jacqueline Costa Teixeira Caramori; João Henrique Castro; Aline Araújo Antunes; Silméia Garcia Zanati-Basan; Beatriz Bojikian Matsubara; Antônio Sérgio Martins

    2012-01-01

    FUNDAMENTO: A hipertrofia ventricular esquerda é potente preditor de mortalidade em renais crônicos. Estudo prévio de nosso grupo mostrou que renais crônicos com menor escolaridade têm hipertrofia ventricular mais intensa. OBJETIVO: Ampliar estudo prévio e verificar se a hipertrofia ventricular esquerda pode justificar a associação entre escolaridade e mortalidade cardiovascular de pacientes em hemodiálise. MÉTODOS: Foram avaliados 113 pacientes entre janeiro de 2005 e março de 2008 e seguido...

  5. Cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactivity in feeding- and reward-related brain areas of young OLETF rats.

    NARCIS (Netherlands)

    Armbruszt, S.; Abraham, H.; Figler, M.; Kozicz, T.L.; Hajnal, A.

    2013-01-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide is expressed in brain areas involved in the control of appetite, drug reward and homeostatic regulation and it has an overall anorexigenic effect. Recently, we have shown that CART peptide immunoreactivity was significantly reduced in the

  6. A Case Illustrating the Costs of Quality Improvement: Nine Months to Move Needles and Syringes on the Anesthesia Cart.

    Science.gov (United States)

    Quick, Alexander K; Macario, Alex; Brock-Utne, John G; Jaffe, Richard A; Kadry, Bassam

    2015-09-01

    Powerful entities are pushing physicians to become more involved with quality improvement (QI). We report a QI project to standardize and improve the ergonomics of the anesthesia medication and supply cart. Simply obtaining approval to make minor changes to the cart involved 54 phone calls, 164 e-mails, 4 presentations, 2 forms, 9 meetings, and 4 months of time. Confusion over fiscal matters further delayed the project by an additional 3 months. A combination of competing regulations, administrative overprocessing, and the lack of dedicated QI financial resources made simple improvements a challenge. The costs of participating in QI deserve attention.

  7. Queratoquiste odontogénico con cartílago en la pared: presentación de un caso

    OpenAIRE

    M Vicente Barrero; Báez Marrero, Oswaldo; Alfonso Martín, Juan Luis; Knezevic, Milan; Báez Acosta, Beatriz

    2004-01-01

    Existen siete casos publicados en la literatura médica referentes a la presencia de cartílago en la pared de un queratoquiste. Presentamos un nuevo caso con inclusiones de queratina y cartílago en la pared quística. Incluimos imágenes clínicas, radiográficas e histopatológicas, así como sus posibilidades etiopatogénicas. There are seven published cases in world literature on cartilage in the walls of odontogenic keratocysts. Herein is presented one further case with ke...

  8. Use of CART analysis to differentiate pollen of red pine ( Pinus resinosa) and jack pine ( P. banksiana) in New England

    Science.gov (United States)

    Barton, Andrew M.; Nurse, Andrea M.; Michaud, Katelyn; Hardy, Sarah W.

    2011-01-01

    The identification of fossil pollen at the generic rather than species level is hampering progress in understanding the biogeography and dynamics of paleo-vegetation. We used CART analysis to facilitate the differentiation of fossil pollen of Pinus banksiana and Pinusresinosa, which are morphologically similar and nearly always combined in paleoecological studies. The CART model, using four of the ten morphological traits measured, exhibited a high level of correct identification for pollen of each of the species and shows promise as a tool for increasing the detail of paleoecological records and inferences.

  9. DeCART v1.2 User's Manual

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Kim, K. S.; Kim, H. Y.; Lee, C. C.; Zee, S. Q; Joo, H. G

    2007-07-15

    DeCART (Deterministic Core Analysis based on Ray Tracing) is a whole core neutron transport code capable of direct subpin level flux calculation at power generating conditions. It does not require a priori homogenization nor group condensation needed in conventional reactor physics calculations. The depletion and transient calculation capabilities are also available. This manual serves as a self-sufficient guide to use the code. First of all, the various features of the code are explained which encompass various modeling options as well as the basic calculation functionalities. The instructions for running the code are also given with a description of the output files generated. Next, the underlying concepts and principles of preparing a DeCART model for a problem under consideration are presented. Each part of the input needed to specify the geometry, material composition, thermal operating condition, program execution control parameters are explained with examples. The descriptions of all the input cards are then followed. Finally, various sample model inputs ranging from a simple 2D pin cell to a realistic 3D core problem, steady-state to transient problems, and from rectangular to hexagonal core problems are presented.

  10. DeCART v1.1 user's manual

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Kim, K. S.; Kim, H. Y.; Lee, C. C.; Zee, S. Q.; Joo, H. G

    2005-03-15

    DeCART (Deterministic Core Analysis based on Ray Tracing) is a whole core neutron transport code capable of direct subpin level flux calculation at power generating conditions. It does not require a priori homogenization nor group condensation needed in conventional reactor physics calculations. The depletion and transient calculation capabilities are also available. This manual serves as a self-sufficient guide to use the code. First of all, the various features of the code are explained which encompass various modeling options as well as the basic calculation functionalities. The instructions for running the code are also given with a description of the output files generated. Next, the underlying concepts and principles of preparing a DeCART model for a problem under consideration are presented. Each part of the input needed to specify the geometry, material composition, thermal operating condition, program execution control parameters are explained with examples. The descriptions of all the input cards are then followed. Finally, various sample model inputs ranging from a simple 2D pin cell to a realistic 3D core problem, steady-state to transient problems, are presented.

  11. Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells.

    Science.gov (United States)

    Boice, Michael; Salloum, Darin; Mourcin, Frederic; Sanghvi, Viraj; Amin, Rada; Oricchio, Elisa; Jiang, Man; Mottok, Anja; Denis-Lagache, Nicolas; Ciriello, Giovanni; Tam, Wayne; Teruya-Feldstein, Julie; de Stanchina, Elisa; Chan, Wing C; Malek, Sami N; Ennishi, Daisuke; Brentjens, Renier J; Gascoyne, Randy D; Cogné, Michel; Tarte, Karin; Wendel, Hans-Guido

    2016-10-01

    The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvironment marked by exacerbated lymphoid stroma activation and increased recruitment of T follicular helper (TFH) cells. These changes result from the disruption of inhibitory cell-cell interactions between the HVEM and BTLA (B and T lymphocyte attenuator) receptors. Accordingly, administration of the HVEM ectodomain protein (solHVEM((P37-V202))) binds BTLA and restores tumor suppression. To deliver solHVEM to lymphomas in vivo, we engineered CD19-targeted chimeric antigen receptor (CAR) T cells that produce solHVEM locally and continuously. These modified CAR-T cells show enhanced therapeutic activity against xenografted lymphomas. Hence, the HVEM-BTLA axis opposes lymphoma development, and our study illustrates the use of CAR-T cells as "micro-pharmacies" able to deliver an anti-cancer protein.

  12. A comparative study of CART and PTM for modelling water age

    Science.gov (United States)

    Wang, Haiyan; Guo, Xinyu; Liu, Zhe; Gao, Huiwang

    2015-02-01

    CART (Constituent-oriented age and residence time theory) and PTM (Particle-tracking method) are two widely used numerical methods to calculate water age. These two methods are essentially equivalent in theory but their results may be different in practice. The difference of the two methods was evaluated by applying them to calculate water age in an idealized one-dimensional domain. The model results by the two methods are consistent with each other in the case with either spatially uniform flow field or spatially uniform diffusion coefficient. If we allow the spatial variation in horizontal diffusion, a term called pseudo displacement arising from the spatial variation of diffusion coefficient likely plays an important role for the PTM to obtain accurate water age. In particular, if the water particle is released at a place where the diffusion is not the weakest, the water age calculated by the PTM without pseudo displacement is much larger than that by the CART. This suggests that the pseudo displacement cannot be neglected in the PTM to calculate water age in a realistic ocean. As an example, we present its potential importance in the Bohai Sea where the diffusion coefficient varies spatially and greatly.

  13. Atmospheric Profile Retrieval with AIRS Data and Validation at the ARM CART Site

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The physical retrieval algorithm of atmospheric temperature and moisture distribution from the Atmospheric InfraRed Sounder (AIRS) radiances is presented. The retrieval algorithm is applied to AIRS clear-sky radiance measurements. The algorithm employs a statistical retrieval followed by a subsequent nonlinear physical retrieval. The regression coefficients for the statistical retrieval are derived from a dataset of global radiosonde observations (RAOBs) comprising atmospheric temperature, moisture, and ozone profiles. Evaluation of the retrieved profiles is performed by a comparison with RAOBs from the Atmospheric Radiation Measurement (ARM) Program Cloud And Radiation Testbed (CART) in Oklahoma,U. S. A.. Comparisons show that the physically-based AIRS retrievals agree with the RAOBs from the ARM CART site with a Root Mean Square Error (RMSE) of 1 K on average for temperature profiles above 850 hPa, and approximately 10% on average for relative humidity profiles. With its improved spectral resolution, AIRS depicts more detailed structure than the current Geostationary Operational Environmental Satellite (GOES) sounder when comparing AIRS sounding retrievals with the operational GOES sounding products.

  14. The prevalence of lameness and associated risk factors in cart mules in Bahir Dar, Ethiopia.

    Science.gov (United States)

    Ali, Alina; Orion, Solomon; Tesfaye, Tewodros; Zambriski, Jennifer A

    2016-10-01

    Ethiopia has 7.1 million donkeys and mules, the majority of which are used as pack animals. Factors such as poor harness quality, long-distance traveling, and heavy cartloads have been linked to reduced work efficiency. Addressing the health and welfare of working equids is imperative not only for the animals but also for the households dependent upon them for livelihood. In developing countries, 75 % of working equids have gait or limb abnormalities, but the relationship between workload and prevalence of lameness is unknown. We examined 450 cart mules in Bahir Dar, Ethiopia. Lameness and workload were assessed through use of a survey and lameness exam. We found that 26.8 % of cart mules were lame, and acute lameness of the forelimb was the most common. Animals with poor harness quality were 2.5 times more likely to have sores and 1.6 times more likely to be lame. Lameness tended to be associated with cartloads >700 kg (P = 0.09), and there was a significant association between multiple-leg lameness and cartload weight (P = 0.03). The presence of sores was the best predictor of lameness (P = 0.001). Possible areas of intervention may include education to reduce average daily workload and improving harness design.

  15. A Comparative Study of CART and PTM for Modelling Water Age

    Institute of Scientific and Technical Information of China (English)

    WANG Haiyan; GUO Xinyu; LIU Zhe; GAO Huiwang

    2015-01-01

    CART (Constituent-oriented age and residence time theory) and PTM (Particle-tracking method) are two widely used numerical methods to calculate water age. These two methods are essentially equivalent in theory but their results may be different in practice. The difference of the two methods was evaluated by applying them to calculate water age in an idealized one-dimensional domain. The model results by the two methods are consistent with each other in the case with either spatially uniform flow field or spatially uniform diffusion coefficient. If we allow the spatial variation in horizontal diffusion, a term called pseudo displacement arising from the spatial variation of diffusion coefficient likely plays an important role for the PTM to obtain accurate water age. In particular, if the water particle is released at a place where the diffusion is not the weakest, the water age calculated by the PTM without pseudo displacement is much larger than that by the CART. This suggests that the pseudo displacement cannot be neglected in the PTM to calculate water age in a realistic ocean. As an example, we present its potential importance in the Bohai Sea where the diffusion coefficient varies spatially and greatly.

  16. A Multivariable Adaptive Control Approach for Stabilization of a Cart-Type Double Inverted Pendulum

    Directory of Open Access Journals (Sweden)

    I. Hassanzadeh

    2011-01-01

    Full Text Available This paper considers the design and practical implementation of linear-based controllers for a cart-type double inverted pendulum (DIPC. A constitution of two linked pendulums placed on a sliding cart, presenting a three Degrees of Freedom and single controlling input structure. The controller objective is to keep both pendulums in an up-up unstable equilibrium point. Modeling is based on the Euler-Lagrange equations, and the resulted nonlinear model is linearized around up-up position. First, the LQR method is used to stabilize DIPC by a feedback gain matrix in order to minimize a quadratic cost function. Without using an observer to estimate the unmeasured states, in the next step we make use of LQG controller which combines the Kalman-Bucy filter estimation and LQR feedback control to obtain a better steady-state performance, but poor robustness. Eventually, to overcome the unknown nonlinear model parameters, an adaptive controller is designed. This controller is based on Model Reference Adaptive System (MRAS method, which uses the Lyapunov function to eliminate the defined state error. This controller improves both the steady-state and disturbance responses.

  17. A new approach to the reduction of "Carte du Ciel" plates

    CERN Document Server

    Ortiz-Gill, A; Brosche, P

    1997-01-01

    A new procedure for the reduction of "Carte du Ciel" plates is presented. A typical "Carte du Ciel" plate corresponding to the Bordeaux zone has been taken as an example. It shows triple exposures for each object and the modelling of the data has been performed by means of a non-linear least squares fitting of the sum of three bivariate Gaussian distributions. A number of solutions for the problems present in this kind of plates (optical aberrations, adjacency photographic effects, presence of grid lines, emulsion saturation) have been investigated. An internal accuracy of 0.1'' in x and y was obtained for the position of each of the individual exposures. The external reduction to a catalogue led to results with an accuracy of 0.16'' in x and 0.13'' in y for the mean position of the three exposures. A photometric calibration has also been performed and magnitudes were determined with an accuracy of 0.09 mags.

  18. Aux frontières poreuses des cartes palestiniennes et de l'art contemporain

    Directory of Open Access Journals (Sweden)

    Anaïs Farine

    2013-12-01

    Full Text Available Un certain nombre d'artistes contemporains palestiniens se saisissent de la carte comme motif (simple présence de carte traditionnelle dans l'espace des œuvres ou comme modèle conceptuel structurant leurs travaux. A travers l'analyse des vidéos M* of Bethlehem [Ayreen Anastas, 2003], Red, Dead and Mediterranean [Akram Al-Ashqar, 2006], et We Began by Measuring Distance [Basma Al-sharif, 2009], cet article entend étudier le déplacement des frontières artistiques ainsi que des représentations de l'espace géopolitique dans les images en mouvements palestiniennes contemporaines. En interrogeant les différents dispositifs mis en place par les trois artistes pour se réapproprier le territoire en lui donnant un sens et une unité, cet article indique que ces œuvres, parce qu'elles répondent avec une grande subtilité aux préoccupations spatiales d'une certaine mouvance de l'art contemporain, sont devenues incontournables.

  19. Method of Inequalities-based Multiobjective Genetic Algorithm for Optimizing a Cart-double-pendulum System

    Institute of Scientific and Technical Information of China (English)

    Tung-Kuan Liu; Chiu-Hung Chen; Zu-Shu Li; Jyh-Horng Chou

    2009-01-01

    This article presents a multiobjective approach to the design of the controller for the swing-up and handstand control of a general cart-double-pendulum system (CDPS).The designed controller,which is based on the human-simulated intelligent control (HSIC) method,builds up different control modes to monitor and control the CDPS during four kinetic phases consisting of an initial oscillation phase,a swing-up phase,a posture adjustment phase,and a balance control phase.For the approach,the original method of inequalities-based (MoI) multiobjective genetic algorithm (MMGA) is extended and applied to the case study which uses a set of performance indices that includes the cart displacement over the rail boundary,the number of swings,the settling time,the overshoot of the total energy,and the control effort.The simulation results show good responses of the CDPS with the controllers obtained by the proposed approach.

  20. A boundary-layer cloud study using Southern Great Plains Cloud and radiation testbed (CART) data

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, B.; Mace, G.; Dong, X.; Syrett, W. [Pennsylvania State Univ., University Park, PA (United States)] [and others

    1996-04-01

    Boundary layer clouds-stratus and fairweather cumulus - are closely coupled involves the radiative impact of the clouds on the surface energy budget and the strong dependence of cloud formation and maintenance on the turbulent fluxes of heat and moisture in the boundary layer. The continuous data collection at the Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site provides a unique opportunity to study components of the coupling processes associated with boundary layer clouds and to provide descriptions of cloud and boundary layer structure that can be used to test parameterizations used in climate models. But before the CART data can be used for process studies and parameterization testing, it is necessary to evaluate and validate data and to develop techniques for effectively combining the data to provide meaningful descriptions of cloud and boundary layer characteristics. In this study we use measurements made during an intensive observing period we consider a case where low-level stratus were observed at the site for about 18 hours. This case is being used to examine the temporal evolution of cloud base, cloud top, cloud liquid water content, surface radiative fluxes, and boundary layer structure. A method for inferring cloud microphysics from these parameters is currently being evaluated.

  1. It’s all change for the "carte de légitimation"

    CERN Multimedia

    2009-01-01

    From now on, the Swiss carte de légitimation will be issued to associates and users as well as staff members, and applications will be handled electronically, thus facilitating various procedures. In collaboration with the GS-AIS Group, the HR Department is continuing its modernisation of administrative procedures. Now that MARS forms and applications to participate in the saved leave scheme have been computerised and employment certificates and change of home address forms have been made available on line on a self-service basis, it’s the turn of the carte de légitimation to enter the digital era. In future, when a new card needs to be produced, the member of the personnel’s data will be forwarded electronically from CERN’s database to the database of the Swiss Federal Department of Foreign Affairs (DFAE), eliminating the need for a paper form. Similarly, paper ID photos will no longer be needed as the digital photo taken for ...

  2. Robust Smooth Time-varying Exponential Stabilization of Dynamic Nonholonomic Mobile Cart with Parameter Uncertainties%参数不确定移动小车的鲁棒镇定

    Institute of Scientific and Technical Information of China (English)

    马保离

    2005-01-01

    For regulating the dynamic nonholonomic mobile cart with parameter uncertainties, a time-varying robust control law is derived to yield globally exponential convergence of cart's position and orientation to the desired set point. The controller design relies on converting the cart's dynamics to an advantageous form, and the robust linear feedback control laws steer the cart's position and orientation errors to zero exponentially. Simulation results show the effectiveness of the proposed control law.

  3. La mortalidad evitable: ¿Cambios en el nuevo siglo? Avoidable mortality: Changes in the new century?

    Directory of Open Access Journals (Sweden)

    Inmaculada Melchor

    2008-06-01

    Full Text Available Objetivos: Estudiar la evolución temporal y la distribución geográfica de la mortalidad evitable en la Comunidad Valenciana y en sus Departamentos de Salud por sexo, en los períodos 1990-1994, 1995-1999 y 2000-2004. Material y método: Se han analizado 21 causas de mortalidad evitable agrupándolas en tratables y prevenibles. Las defunciones analizadas corresponden a residentes en la Comunidad Valenciana durante el período 1990-2004. Se han calculado las tasas ajustadas por edad (método directo y las razones de mortalidad comparativas para el estudio de la evolución temporal en los ámbitos geográficos indicados por período y sexo. Las razones de mortalidad estandarizadas (método indirecto se han utilizado en el análisis de la distribución geográfica. Resultados: El total de defunciones evitables son 38.061 (un 7,1% de la mortalidad global, el 76,2% corresponden a varones y el 23,8% a mujeres. Por grupos, el 82,4% son prevenibles y el 17,6% tratables. En varones, las prevenibles representan un 86,5%, y en mujeres un 69,4%. En la Comunidad Valenciana se observan descensos significativos de la mortalidad evitable en ambos sexos, más acusados en las tratables, y en hombres. La mortalidad por cáncer de pulmón en mujeres presenta un aumento significativo. En 2000-2004 ningún departamento de salud presenta excesos de mortalidad estadísticamente significativos en las tratables. Conclusiones: La mortalidad evitable desciende más que la mortalidad general en la Comunidad Valenciana. Cabe destacar el aumento de la mortalidad por cáncer de pulmón en las mujeres.Objectives: To analyze time trends and the geographical distribution of avoidable mortality in the autonomous community of Valencia and its health departments by sex in the periods 1990-1994, 1995-1999, and 2000-2004. Material and method: Twenty-one causes of avoidable mortality were analyzed. The deaths analyzed corresponded to residents in the autonomous community of Valencia

  4. Morbi-mortalidad de la endarterectomía carotídea

    Directory of Open Access Journals (Sweden)

    Virginia A. Pujol Lereis

    2011-10-01

    Full Text Available La endarterectomía carotídea (EC en adición al mejor tratamiento médico mostró reducción del riesgo de eventos cerebrovasculares en pacientes sintomáticos y asintomáticos con estenosis moderada-grave del vaso en ensayos clínicos en centros académicos con cirujanos altamente seleccionados. Las principales guías internacionales recomiendan que el procedimiento se realice en centros con morbi-mortalidad auditada menor al 6% para pacientes sintomáticos y 3% para asintomáticos. Evaluamos la morbi-mortalidad peri-procedimiento en nuestro centro. Esta fue definida como la presencia de accidente cerebrovascular, infarto de miocardio y/o muerte dentro de los 30 días de la cirugía. Se indicó el procedimiento en pacientes sintomáticos con estenosis > 50%. En pacientes asintomáticos o sintomáticos con estenosis ≤ 50% se decidió el tratamiento sobre una base caso por caso. Todos los pacientes fueron examinados por un neurólogo y un cardiólogo antes y después de la EC. Se utilizó en forma rutinaria monitoreo intraoperatorio con Doppler transcraneano en los pacientes con adecuada ventana ultrasónica. Se evaluaron 306 endarterectomías carotídeas. No se registraron muertes. La morbilidad perioperatoria fue de 2.6% tanto para individuos sintomáticos como asintomáticos. Estos índices se compararon favorablemente con informes de otros centros de Latinoamérica y Europa. En conclusión, este informe muestra que la EC puede realizarse en la práctica clínica cotidiana con morbi-mortalidad peri-procedimiento dentro de los niveles recomendados por las guías internacionales.

  5. Mortalidade materna de mulheres negras no Brasil Maternal mortality among black women in Brazil

    Directory of Open Access Journals (Sweden)

    Alaerte Leandro Martins

    2006-11-01

    Full Text Available A cada minuto uma mulher morre no mundo em decorrência do trabalho de parto ou complicações da gravidez. A mortalidade materna configura-se no Brasil como um problema de saúde pública, atingindo desigualmente as várias regiões brasileiras. É consenso que a mulheres acometidas pela morte materna são as de menor renda e escolaridade. Juntamente com as questões sócio-econômicas, emerge a questão racial. A análise é difícil de ser realizada em virtude da dificuldade de entendimento da classificação raça/cor que muitas vezes impede o registro dessa informação. Vários Comitês de Morte Materna estão utilizando o quesito cor e revisando seus dados. Este artigo analisa vários relatórios de Comitês de Morte Materna, mostrando que o risco de mortalidade materna é maior entre as mulheres negras, o que inclui as pretas e pardas, configurando-se em importante expressão de desigualdade social. Ao final, apresenta-se uma revisão de recomendações para diminuição da Mortalidade Materna, enfatizando ações políticas e técnicas que possam contribuir para tal.Every minute a woman dies in the world due to labor or complications of pregnancy. Maternal mortality is a public health problem in Brazil and affects the country's various regions unequally. Researchers agree that maternal death occurs mainly in women with lower income and less schooling. The racial issue emerges in the midst of socioeconomic issues. The analysis is hampered by the difficulty in understanding Brazil's official classification of race/color, which often impedes recording this information. Various Maternal Mortality Committees are applying the color item and reviewing their data. The current article analyzes various Maternal Mortality Committee reports, showing that the risk of maternal mortality is greater among black women (which encompasses two census categories, negra, or black, and parda, or brown, thus representing a major expression of social inequality

  6. Mortalidade perinatal em São Paulo, Brasil Perinatal mortality in S. Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Ruy Laurenti

    1975-06-01

    Full Text Available Foi analisada a mortalidade perinatal em São Paulo num período de dois anos. Partiu o estudo da totalidade dos atestados de nascidos mortos e de uma amostra de óbitos de menores de sete dias, para a qual a metodologia foi a de entrevistas domiciliares e junto aos médicos e hospitais que tenham prestado assistência às crianças falecidas. O coeficiente de mortalidade perinatal encontrado foi igual a 42,04 por mil nascidos vivos. Esse valor apresenta-se bastante elevado quando comparado ao de áreas desenvolvidas. Foi verificado que ele poderia ser diminuído com a simples redução dos coeficientes específicos por algumas causas evitáveis a nível de pré-natal (sífilis congênita, doenças próprias ou associadas à gravidez, do parto (distócias, traumatismos obstétricos e anóxia, ou da atenção ao recém-nascido (causas infecciosas, do aparelho respiratório, hemorragias e certas anóxias. O coeficiente de mortalidade perinatal segundo a idade da mãe mostrou que o risco varia com a idade, apresentando-se maior nas mulheres de 40 a 49 anos.Perinatal mortality in S. Paulo, over a period of two years, was analysed. The study took in all death certificates of the stillborn and a sample of children under a week of age. For the latter the methodology used was by interviewing phisicians and hospitals that cared for the deceased. The perinatal mortality rate was 42,05 per thousand live births. This value is really high when compared with those of developed areas. Nevertheless it can be reduced once the specific rates for some of the avoidable diseases be reduced by proper pre-natal care (congenital syphilis, illness pertaining to or associated with pregnancy. This can also be done by improving care at delivery (Distocias, obstetrical traumatism and anoxia and towards the newlyborn (infeccious diseases, respiratory diseases, haemorrages and anoxia. The perinatal mortality rate varies with the age of the mother, the risk being largest in

  7. EVOLUCIÓN DE LA MORTALIDAD ATRIBUIBLE AL TABACO EN LAS ISLAS CANARIAS (1975-1994

    Directory of Open Access Journals (Sweden)

    Luis M Bello Luján

    2001-01-01

    Full Text Available Fundamento: El objetivo de este trabajo es describir la mortalidad atribuible al consumo de tabaco en las Islas Canarias durante el período 1975-1994. Método: Las defunciones por edad, sexo y causa desde 1975 a 1994 se obtuvieron del Instituto Nacional de Estadística (Movimiento Natural Población. A partir de las Encuestas de Salud de España y Canarias se tomaron los porcentajes de nunca fumadores, fumadores y ex-fumadores de la población canaria por edad y sexo. Los riesgos relativos de muerte se obtuvieron del Cancer Prevention Study II, llevado a cabo en Estados Unidos de América. Se calculó la proporción de muertes atribuibles al tabaco para cada año, sexo y grupo de edad a partir de la fracción atribuible poblacional. Así mismo, se calculó la tendencia de la mortalidad atribuible para dicho período expresada como el cambio porcentual medio anual de las tasas de la mortalidad ajustadas por edad, mediante un modelo log-lineal. Resultados: Durante el período 1975-1994, el número de fallecimientos atribuidos al tabaco aumentó un 64%. Por grandes causas, se observó en el período de estudio, un aumento de las neoplasias del 108%, una disminución de las enfermedades cardiovasculares del 32% y un incremento de las enfermedades respiratorias del 15,5%. Se observó también que el número de fallecidos aumenta con la edad, siendo el grupo de edad de 65 años y más en el que se presentan más muertes por el tabaco. Conclusiones: En las Islas Canarias, más del 20% de todas las muertes en 1994 se pueden atribuir al tabaco. Esto sugiere que las medidas introducidas para controlar el tabaquismo son insuficientes.

  8. Tendência da mortalidade perinatal em Belo Horizonte, 1984 a 2005 Tendencia de la mortalidad perinatal en Belo Horizonte, 1984 a 2005 Tendency of perinatal mortality in Belo Horizonte, 1984 to 2005

    Directory of Open Access Journals (Sweden)

    Eunice Francisca Martins

    2010-06-01

    Full Text Available O estudo objetivou analisar a tendência da mortalidade perinatal no município de Belo Horizonte no período de 1984 a 2005. A fonte dos dados foi o Sistema de Informação de Mortalidade (SIM. Realizou-se regressão linear simples para estimar a tendência de redução do percentual de informações ignoradas no SIM e das taxas de mortalidade. A melhora da qualidade da informação foi estatisticamente significativa apenas para a escolaridade materna e peso ao nascer. A redução média da mortalidade perinatal no período foi de 57,52%. O decréscimo da mortalidade perinatal nas duas últimas décadas em Belo Horizonte foi significativo, mas esforços devem ser direcionados no sentido de melhorar a completude do SIM para variáveis importantes na elaboração dos indicadores perinatais.El estudio apuntó a analizar la tendencia de la mortalidad perinatal en el distrito municipal de Belo Horizonte en el periodo de 1984 a 2005. La fuente de los datos era el Sistema de Información de Mortalidad. Tuvieron lugar la regresión lineal simple para estimar la tendencia de reducción del percentil de información desconocida en el sistema y de los impuestos de mortalidad. La mejora de la calidad de la información fue los significantes sólo para la educación maternal y peso al nacer. La reducción elemento de la mortalidad perinatal en el periodo era de 57,52%. La disminución de la mortalidad perinatal en las últimas dos décadas en Belo Horizonte era significante, pero deben dirigirse los esfuerzos en el sentido de mejorar el completude del sistema para las variables importantes en la elaboración del perinatais de los indicadores.The study aimed at to analyze the tendency of the mortality perinatal in the municipal district of Belo Horizonte in the period from 1984 to 2005. The source of the data was the System of Information of Mortality. Took place simple lineal regression to esteem the tendency of reduction of the percentile of unknown

  9. Estudio bibliométrico de la revista Nutrición Hospitalaria en el periodo 2001 a 2005: parte 2, análisis de consumo; las referencias bibliográficas Bibliometric study of the journal Nutrición Hospitalaria for the period 2001-2005: part 2, consumption analysis; the bibliographic references

    Directory of Open Access Journals (Sweden)

    V. T. Castera

    2008-12-01

    Full Text Available Objetivo: Describir y evaluar el consumo de información consultada y citada en los artículos publicados en la revista Nutrición Hospitalaria en el periodo 2001 a 2005, mediante el análisis bibliométrico. Método: Estudio descriptivo transversal, de los resultados obtenidos del análisis de los listados de las referencias bibliográficas de los artículos publicados en Nutrición Hospitalaria. Se estudio las revistas más citadas, el índice de firmas, la tipología documental referida, el idioma de publicación, la distribución geográfica de filiación y la obsolescencia e índice de inmediatez. Se tuvo en cuenta todas las tipologías documentales, a excepción de las Comunicaciones a Congresos. Resultados: Se publicaron en Nutr Hosp 345 artículos, que contenían un total de 8.113 referencias bibliográficas, con una mediana de 18, un máximo de 136 y un mínimo de 0 RB por artículo. La media (tasa del periodo calculado de referencias por publicación es de 23,52 (IC 95% 20,93-26,10 y la media recortada al 5% de 20,66 por artículo. El percentil 25 es de 6 y el 75 de 32, siendo el intervalo intercuartílico de 26 RB por documento. El semiperiodo de Burton y Kebler es de 7 años y el Índice de Price es del 38,18%. Conclusión: Las referencias bibliográficas, el consumo de información, de los artículos publicados en Nutrición Hospitalaria presentan parámetros similares a otras revistas sobre ciencias de la salud. Ahora bien, se aprecian unos buenos datos de obsolescencia, situación que revela la buena vigencia de la mayoría de las referencias estudiadas.Objective: To describe and assess the consumption of the information consulted and cited in the articles published in the journal Nutrición Hospitalaria for the period 2001-2005 by means of bibliometric analysis. Method: Cross-sectional descriptive analysis of the results obtained from the analysis of the lists of bibliographic references of the articles published at Nutrici

  10. Estudio bibliométrico de la revista Nutrición Hospitalaria en el periodo 2001 a 2005: Parte I, análisis de la producción científica Bibliometric study of the journal Nutrición Hospitalaria for the period 2001-2005: Part 1, analysis of the scientific production

    Directory of Open Access Journals (Sweden)

    V. T. Casterá

    2008-10-01

    Full Text Available Objetivo: Evaluar la actividad científica y la producción de información de la revista Nutrición Hospitalaria, en el periodo 2001 a 2005, mediante el análisis bibliométrico. Método: Estudio descriptivo transversal, de los resultados obtenidos del análisis de los artículos publicados en la revista Nutrición Hospitalaria. Los datos se obtuvieron mediante la consulta, a través de la Red, de la versión electrónica. En aquellos casos que se aprecio una ruptura del enlace, y por tanto la imposibilidad de acceder al documento electrónico, se recurrió a la versión impresa. Se tuvo en cuenta todas las tipologías documentales, a excepción de las Comunicaciones a Congresos. Resultados: Se publicaron un total de 345 artículos, siendo originales 187 artículos (54,20%. La distribución geográfica del primer firmante es española en 287 artículos (83,19% y en 27 de ellos (7,83% ibero-americana. La mayor cantidad de artículos proceden de centros sanitarios 172 artículos (49,86%, el índice de cooperación es igual a 4.15. Madrid es la provincia más productiva, tanto en frecuencia absoluta como ajustada. La mediana de referencias por artículo igual a 18, siendo la media de 23,52 (IC 95% 20,93-26,10. El idioma predominante es el español 308 artículos (89,28%. Conclusión: Nutrición Hospitalaria puede considerarse referente de la información y comunicación científica española e iberoamericana en Nutrición. Los parámetros bibliométricos estudiados son comparables a los verificados en el resto de revistas punteras sobre ciencias de la salud españolas.Objective: To assess the scientific activity and information production of the journal Nutrición Hospitalaria, for the period 2001-2005 by means of a Bibliometric study. Method: Cross-sectional descriptive study of the results obtained from the analysis of the articles published in the journal Nutrición Hospitalaria. The data were obtained by consulting the electronic version

  11. Neumonia adquirida en la comunidad en dos poblaciones hospitalarias Community-acquired pneumonia in patients from two different hospitals

    Directory of Open Access Journals (Sweden)

    O. J. Caberlotto

    2003-01-01

    Full Text Available Se estudiaron en forma prospectiva pacientes con diagnóstico de neumonía adquirida en la comunidad que acudieron a la consulta en un hospital general y en un centro especializado en medicina respiratoria ubicados en la provincia de Buenos Aires, y que requirieron internación. Se evaluaron la distribución por sexo y edad, las comorbilidades asociadas, los agentes etiológicos, su incidencia y la mortalidad. Se incluyeron 52 pacientes (marzo 1998-febrero 1999 del Hospital General de Agudos Manuel Belgrano (HMB y 23 pacientes (junio 2000-mayo 2001 del Hospital del Tórax Dr. Antonio A. Cetrángolo (HCET. Se excluyeron pacientes con tuberculosis o micosis pulmonar, neoplasia de pulmón y diagnóstico serológico para HIV. Se completó una historia clínica y se realizaron estudios microbiológicos para gérmenes comunes, virus respiratorios y micobacterias. Para el estudio de los agentes productores de neumonías atípicas (Chlamydia spp, Coxiella burnetii, Mycoplasma pneumoniae y Legionella spp. y como complemento del estudio virológico, se utilizaron pruebas serológicas. No se observaron diferencias por sexo y edad en los dos grupos. En el HMB las comorbilidades más frecuentes fueron EPOC, diabetes e insuficiencia cardíaca, en tanto que en el HCET fueron EPOC, asma y fibrosis pulmonar. Se obtuvo un diagnóstico microbiológico en el 48% y 65.2% de los pacientes para ambos grupos. Los agentes hallados más frecuentemente fueron Mycoplasma pneumoniae, Streptococcus pneumoniae, influenza A y Legionella spp, este último germen con una incidencia del 12% en pacientes que evolucionaron favorablemente y que en su mayoría pertenecían al HMB. La mortalidad fue similar para ambos grupos (13.3%. En el HMB estuvo relacionada con la existencia de comorbilidades en 7 de 8 casos y en el HCET con el agravamiento de la insuficiencia respiratoria crónica.Patients hospitalized with community acquired pneumonia were studied prospectively in two hospitals

  12. Resistencia y susceptibilidad de microorganismos aislados en pacientes atendidos en una institución hospitalaria de tercer nivel, Villavicencio-Colombia, 2012

    Directory of Open Access Journals (Sweden)

    Oscar Alexander Gutiérrez Lesmes

    2015-05-01

    Full Text Available Introducción: La resistencia bacteriana es problema significativo de salud pública y está asociada al uso indiscriminado e irracional de antibióticos, lo que afecta la eficacia de los tratamientos. Objetivo: Estimar la resistencia antimicrobiana a los antibióticos resultado de las pruebas invitro de susceptibilidad en una institución hospitalaria de tercer nivel de Villavicencio, Colombia. Materiales y Métodos: Se realizó un estudio observacional, descriptivo de tipo retrospectivo, análisis univariado, calculando medias de las variables susceptibilidad, resistencia, antibiótico, microorganismos, y tipo de muestra resultados de las pruebas de susceptibilidad realizadas mediante técnica de Kirby-Bauer de 485 pruebas de susceptibilidad de la institución hospitalaria. Resultados y Discusión: Los microorganismos más frecuentemente aislados, fueron: Escherichia coli, Klebsiella pneumoniae ss. Pneumoniae, Staphylococcus aureus ss. Aureus representando el 49% de total de microorganismos, los mayores reportes de resistencia en la pruebas invitro las presentaron Serratia marcescens, Staphylococcus saprophyticus ss. Saprophytic, Enterobacter cloacae, presentan una resistencia media superior al 50%, y una susceptibilidad inferior 40%, la mayor resistencia media se presentó para los siguientes antibióticos, Cefalotina 72,2%, Cefazolina 59,9%, Nitrofurantoina 54,4%, Ceftriaxona 52,7%. Conclusiones: Antibióticos como la Cefalotina, Nitrofurantoina, Cefazolina y Ceftriaxona  pierden su utilidad terapéutica dada la elevada resistencia demostrada por los microorganismos aislados en las pruebas invitro, es necesario reforzar las medidas de uso adecuado de antibióticos para disminuir la posibilidad de adaptación y resistencia a los mismos,  el fenómeno de resistencia bacteriana ocurre fuera del ámbito hospitalario evidenciando la necesidad de iniciar también control y vigilancia en infecciones ocurridas en la comunidad.Cómo citar este

  13. Cross-culture revision of CART-Q%对教练员与运动员关系量表(CART-Q)的跨文化修订

    Institute of Scientific and Technical Information of China (English)

    钟日升; 王迪

    2010-01-01

    教练员与运动员关系时运动员的训练、生活和运动成绩均有重要的影响,因此国外许多运动心理学家尝试致力于此领域研究,但国内鲜有相关研究.英国运动心理学家Jowett近年提出的3C理论及CART-Q量表,通过研究证明该量表适用于中国教练员与运动员.针对中国举国体制的现实国情和传统文化对教练员与运动员的影响,对原量表进行了修订,获得该量表的中文修订版的心理测量学数据.研究发现CART-Q修订版比翻译版在中国使用具有更好的信度、效度.

  14. Las inequidades geográficas en la mortalidad infantil en Costa Rica, período 2008-2012

    Directory of Open Access Journals (Sweden)

    Horacio Alejandro Chamizo García

    2014-07-01

    Full Text Available Se presenta un estudio exploratorio ecológico sobre la mortalidad infantil en Costa Rica, sus inequidades geográficas y determinantes sociales. Se calculó la tasa mortalidad infantil, el riesgo relativo de morir para menores de un año de vida por unidades territoriales (del año 2008 al 2012 y se representó cartográficamente. Se analizó el patrón espacial de la mortalidad infantil estableciendo correlaciones lineales con diversos indicadores socioeconómicos, como el índice de desarrollo humano, gini y un indicador sintético de calidad ambiental a nivel doméstico y comunal. Los territorios con mayor riesgo de morir se localizan hacia zonas fronterizas y costeras, así como las peores condiciones socioeconómicas y calidad ambiental. Se ha evidenciado que, en la medida que empeoran las condiciones socioeconómicas y ambientales en los cantones, se incrementa la mortalidad infantil.

  15. Mortalidade de adolescentes em área urbana da região Sudeste do Brasil, 1984-1993

    Directory of Open Access Journals (Sweden)

    Lyra Sílvia M. Kawata

    1996-01-01

    Full Text Available Analisa-se a mortalidade de adolescentes no Município de Botucatu, Estado de São Paulo, Brasil, no período de 1984 a 1993, segundo dois subgrupos (10 a 14 e 15 a 19 anos, sexo, ocupação e causas de óbito. Os dados de óbitos foram obtidos no Setor de Estatística do Centro de Saúde-Escola. As estimativas populacionais foram calculadas com base nos censos demográficos. Observou-se variação dos coeficientes de mortalidade nos diferentes anos e maior mortalidade no grupo masculino de 15 a 19 anos, atingindo tanto estudantes como trabalhadores. Houve predomínio de causas externas de mortalidade, principalmente acidentes de trânsito e ferimento por arma de fogo, exigindo averigüação de seus determinantes e o desenvolvimento de programas de saúde destinados aos adolescentes, suas famílias e à sociedade, considerando-se que as causas de morte são evitáveis e preveníveis.

  16. Comorbilidad como predictor de utilización de servicios sanitarios y mortalidad en pacientes con diabetes

    Directory of Open Access Journals (Sweden)

    Patricia Carrera-Lasfuentes

    2015-01-01

    Conclusiones: El sistema ACG permite predecir el consumo de recursos y la mortalidad de este colectivo en nuestro medio. Este estudio confirma la importante carga asistencial que generan los enfermos de diabetes mellitus y subraya la necesidad de tomar medidas al respecto.

  17. Las inequidades geográficas en la mortalidad infantil en Costa Rica, período 2008-2012

    Directory of Open Access Journals (Sweden)

    Horacio Alejandro Chamizo García

    2014-01-01

    Full Text Available Se presenta un estudio exploratorio ecológico sobre la mortalidad infantil en Costa Rica, sus inequidades geográficas y determinantes sociales. Se calculó la tasa mortalidad infantil, el riesgo relativo de morir para menores de un año de vida por unidades territoriales (del año 2008 al 2012 y se representó cartográficamente. Se analizó el patrón espacial de la mortalidad infantil estableciendo correlaciones lineales con diversos indicadores socioeconómicos, como el índice de desarrollo humano, gini y un indicador sintético de calidad ambiental a nivel doméstico y comunal. Los territorios con mayor riesgo de morir se localizan hacia zonas fronterizas y costeras, así como las peores condiciones socioeconómicas y calidad ambiental. Se ha evidenciado que, en la medida que empeoran las condiciones socioeconómicas y ambientales en los cantones, se incrementa la mortalidad infantil.

  18. Factores asociados a la mortalidad global en los pacientes diagnosticados de enfermedad pulmonar obstructiva crónica

    Directory of Open Access Journals (Sweden)

    Josep Montserrat-Capdevila

    2015-10-01

    Conclusiones: La aplicación de estas variables, fáciles y factibles de recoger en la práctica clínica, permitiría identificar a aquellos pacientes con mayor riesgo de mortalidad y que podrían beneficiarse de estrategias preventivas/terapéuticas para conseguir aumentar la supervivencia.

  19. Mortalidade por transtornos mentais e comportamentais e a reforma psiquiátrica no Brasil contemporâneo

    Directory of Open Access Journals (Sweden)

    Fernando Portela Câmara

    2008-06-01

    Full Text Available A mortalidade por transtornos mentais e comportamentais têm aumentado no Brasil com a redução progressiva das internações hospitalares. A reforma psiquiátrica do governo aparentemente está contribuindo para este cenário preocupante, com sua política de desospitalização.

  20. Mortalidad infantil y migración en Chiapas, México

    OpenAIRE

    Olga Lidia Lópes-Gonzáles; Benito Salvatierra-Izaba; Austreberta Nazar-Beutelspacher; Héctor Javier Sánchez-Pérez

    2010-01-01

    El objetivo de este trabajo fue analizar, en términos causales, la relación entre mortalidad infantil y migración en cuatro zonas socioeconómicas de la región Soconusco en Chiapas, México. El análisis de este estudio se basó en los resultados de una encuesta socio demográfica y de salud con base poblacional (probabilística) que se llevó a cabo en el Soconusco, Chiapas en 1996-97. Se contrastan zonas con distinta condición socioeconómica, cultural y productiva. Se realizó análisis de regresión...

  1. Mortalidade perinatal em cabritos no semi-árido da Paraíba

    OpenAIRE

    Medeiros,Josemar Marinho de; Tabosa,Ivon Macêdo; Simões,Sara Vilar Dantas; Nóbrega Júnior,Janduí Escarião da; Vasconcelos,Jackson Suélio de; Riet-Correa, Franklin

    2005-01-01

    As causas de mortalidade perinatal em cabritos foram estudadas de maio de 2002 a agosto de 2004. Em 118 cabritos necropsiados as causas de morte foram: infecção neonatal (50%), distocia (12,71%), complexo hipotermia/inanição (11,86%), malformações (7,62%), síndrome do cabrito mole (6,77%) e abortos (1,69%). Com relação ao momento da morte 1,69% dos cabritos morreram antes do parto, 16,94% durante o parto e 81,34 % após o nascimento. A alta ocorrência de infecções neonatais, distocias e hipote...

  2. O escore de risco de sangramento como preditor de mortalidade em pacientes com síndromes coronarianas agudas

    Directory of Open Access Journals (Sweden)

    José Carlos Nicolau

    2013-12-01

    Full Text Available FUNDAMENTO: A ocorrência de sangramento aumenta a mortalidade intra-hospitalar em pacientes com síndromes coronarianas agudas (SCAs, e há uma boa correlação entre os escores de risco de sangramento e a incidência de eventos hemorrágicos. No entanto, o papel dos escores de risco de sangramento como fatores preditivos de mortalidade é pouco estudado. OBJETIVO: Analisar o papel do escore de risco de sangramento como fator preditivo de mortalidade intra-hospitalar numa coorte de pacientes com SCA tratados num centro terciário de cardiologia. MÉTODOS: Dos 1.655 pacientes com SCA (547 com SCA com supra de ST e 1.118 com SCA sem supra de ST, calculou-se o escore de risco de sangramento ACUITY/HORIZONS prospectivamente em 249 pacientes e retrospectivamente nos demais 1.416. Informações sobre mortalidade e complicações hemorrágicas também foram obtidas. RESULTADOS: A idade média da população estudada foi 64,3 ± 12,6 anos e o escore de risco de sangramento médio foi 18 ± 7,7. A correlação entre sangramento e mortalidade foi altamente significativa (p < 0,001; OR = 5,29, assim como a correlação entre escore de sangramento e hemorragia intra-hospitalar (p < 0,001; OR = 1,058, e entre escore de sangramento e mortalidade intra-hospitalar (OR ajustado = 1,121, p < 0,001, área sob a curva ROC 0,753; p < 0,001. O OR ajustado e a área sob a curva ROC para a população com SCA com supra de ST foram 1,046 (p = 0,046 e 0,686 ± 0,040 (p < 0,001, respectivamente, e para SCA sem supra de ST foram 1,150 (p < 0,001 e 0,769 ± 0,036 (p < 0,001, respectivamente. CONCLUSÃO: O escore de risco de sangramento é um fator preditivo muito útil e altamente confiável para mortalidade intra-hospitalar em uma grande variedade de pacientes com SCAs, especialmente aqueles com angina instável ou infarto agudo do miocárdio sem supra de ST.

  3. Tendencia de la tasa de mortalidad en una prisión española (1994-2004

    Directory of Open Access Journals (Sweden)

    Enrique Jesús Vera Remartínez

    2005-01-01

    Full Text Available Fundamento: Hay pocos trabajos sobre mortalidad en el ámbito penitenciario. El objetivo es describir las causas, tasas de mortalidad y su tendencia en una prisión española. Métodos: Estudio descriptivo, de los fallecimientos en una prisión entre 01-01-1994 y 31-12-2004. Se recogieron las variables edad, sexo, fecha del óbito, serología VIH, número de CD4+ en su caso, y causa de muerte según la clasificación: muerte por VIH, por enfermedad no VIH, suicidio, intoxicación por drogas, y accidentes. Previa estandarización indirecta de tasas, comparamos la mortalidad del Centro con la del resto de las prisiones españolas. Establecimos la tendencia de las tasas de mortalidad mediante un modelo de regresión lineal. Resultados: 42 muertes, 41 hombres, 1 mujer. Mediana de edad de 33,10 años (27,72 - 36,12; IQR: 8,40. 30 (71,4% VIH+, con mediana de 177 linfocitos CD4+/µl 20 pacientes (45,24% fallecieron por VIH, 15 (38,10% por enfermedades no VIH, 3 (7,14% suicidios, 3 (7,14% intoxicaciones por drogas y 1 (2,38% accidentalmente. Las tasas crudas de mortalidad estuvieron entre 12,605‰ internos/año en 1997 y 1,758‰ internos/año en 2003, con tendencia descendente a razón de 0,976 muertes‰ internos/año (IC95%: 0,399-1,552; p=0,004. Estandarizando tasas nos corresponderían 28,6 muertes esperadas en el período, con una SMR de 1,4679. Conclusiones: Aunque la tendencia es descendente, la tasa de mortalidad obtenida en el período estudiado fue mayor que la esperada. La principal causa de mortalidad fue el síndrome de inmunodeficiencia adquirida.

  4. Caracterización de la mortalidad fetal tardía en Villa Clara.

    Directory of Open Access Journals (Sweden)

    Juan Antonio Suárez González

    2011-10-01

    Full Text Available Fundamento: Eventos como la mortalidad fetal tardía agreden la evolución normal esperada en el embarazo, con una connotación en la mujer, la pareja y la comunidad. Objetivo: Caracterizar la mortalidad fetal tardía según factores asociados. Métodos: Se realizó un estudio descriptivo de las 74 muertes fetales registradas en el Hospital Universitario Ginecoobstétrico Mariana Grajales de Santa Clara, durante los años 2009 y 2010. Se analizaron las variables: edad materna, antecedentes patológicos personales maternos, edad gestacional al momento de la muerte fetal, lugar y momento de ocurrencia y causas de la muerte. Resultados: El 67,6 % de las gestantes tenían entre 20 y 35 años. La hipertensión arterial crónica y el asma bronquial fueron los antecedentes patológicos personales de mayor incidencia entre las gestantes. Ocurrieron los óbitos fetales en una edad gestacional entre 28 y 36,6 semanas fundamentalmente. El 52,7 % de las muertes ocurrieron fuera del hospital y antes del parto en 55 casos (74,3 %. Resultaron las causas más frecuentes las idiopáticas y los trastornos hipertensivos de la gestación. Conclusiones: Es necesario intensificar el control del riesgo reproductivo preconcepcional y la atención prenatal, pues sin dudas, aunque mucho se ha logrado en este sentido, los resultados del estudio muestran que en alguna medida las causas de los óbitos fetales fueron prevenibles.

  5. Mortalidad evitable y políticas en salud. Colombia, 1985-2002

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    Rubén Darío Gómez-Arias

    2009-12-01

    Full Text Available Introducción: La confianza en la capacidad de evitar algunas muertes o diferir su aparición es el fundamento de toda política de salud, uno de cuyos principales resultados debe ser reducir las muertes evitables, y controlar las condiciones que aumentan el riesgo de morir.Objetivos: Establecer variaciones en la tendencia de la mortalidad evitable (ME registrada en Colombia entre 1985 y 2002, como indicadoras del impacto efectivo que las reformas en la política sanitaria pudieran haber tenido sobre sus determinantes.Métodos: Estudio de la ME con base en los registros oficiales de defunción y en las proyecciones censales de Colombia entre 1985-2002. Para determinar la evitabilidad, se aplicó un inventario de causas de ME (ICME ajustado a las condiciones epidemiológicas del país durante el período que se analiza.Resultados: De las muertes registradas, 75.3% se clasificaron como evitables. Se identificaron siete patrones de tendencia que reflejan, de manera particular, los efectos de las políticas públicas sobre los determinantes de la mortalidad.Conclusiones: En general, la ME viene disminuyendo en Colombia desde 1985 en la población general y entre los hombres, sin variaciones significativas durante el período. Las variaciones en la tendencia de las tasas ajustadas de varios grupos de causas hacen pensar en un deterioro en el control de sus determinantes, especialmente desde 1990. Los cambios aplicados en las políticas públicas durante los últimos años no se reflejaron en un mejor control de las muertes evitables, aunque el gasto en salud aumentó de modo muy notable en el país.

  6. Mortalidad evitable y políticas en salud. Colombia, 1985-2002

    Directory of Open Access Journals (Sweden)

    Rubén Darío Gómez-Arias

    2010-08-01

    Full Text Available Introducción: La confianza en la capacidad de evitar algunas muertes o diferir su aparición es el fundamento de toda política de salud, uno de cuyos principales resultados debe ser reducir las muertes evitables, y controlar las condiciones que aumentan el riesgo de morir. Objetivos: Establecer variaciones en la tendencia de la mortalidad evitable (ME registrada en Colombia entre 1985 y 2002, como indicadoras del impacto efectivo que las reformas en la política sanitaria pudieran haber tenido sobre sus determinantes. Métodos: Estudio de la ME con base en los registros oficiales de defunción y en las proyecciones censales de Colombia entre 1985-2002. Para determinar la evitabilidad, se aplicó un inventario de causas de ME (ICME ajustado a las condiciones epidemiológicas del país durante el período que se analiza. Resultados: De las muertes registradas, 75.3% se clasificaron como evitables. Se identificaron siete patrones de tendencia que reflejan, de manera particular, los efectos de las políticas públicas sobre los determinantes de la mortalidad. Conclusiones: En general, la ME viene disminuyendo en Colombia desde 1985 en la población general y entre los hombres, sin variaciones significativas durante el período. Las variaciones en la tendencia de las tasas ajustadas de varios grupos de causas hacen pensar en un deterioro en el control de sus determinantes, especialmente desde 1990. Los cambios aplicados en las políticas públicas durante los últimos años no se reflejaron en un mejor control de las muertes evitables, aunque el gasto en salud aumentó de modo muy notable en el país.

  7. Design of an automated cart and mount for a hyperspectral imaging system to be used in produce fields

    Science.gov (United States)

    The goal of this project was to construct a cart and a mounting system that would allow a hyperspectral laser-induced fluorescence imaging system (HLIFIS) to be used to detect fecal material in produce fields. Fecal contaminated produce is a recognized food safety risk. Previous research demonstrate...

  8. Turning a Common Lab Exercise into a Challenging Lab Experiment: Revisiting the Cart on an Inclined Track

    Science.gov (United States)

    Amato, Joseph C.; Williams, Roger E.

    2010-01-01

    A common lab exercise in the introductory college physics course employs a low-friction cart and associated track to study the validity of Newton's second law. Yet for college students, especially those who have already encountered a good high school physics course, the exercise must seem a little pointless. These students have already learned to…

  9. 循迹小车的追踪与避障%The Tracing and Obstacle Avoidance of Tracking Carts

    Institute of Scientific and Technical Information of China (English)

    王宇洋; 许志; 杨柳; 张家一; 张晓亮

    2012-01-01

    This paper introduces the design and realization of auto-tracking carts based on the use of gray level sensors. This cart tracks certain black lines on the white floor. When detecting objects at front, the cart starts to chase the object. By changing the pro- grams, the cart can avoid obstacles and turn itself automatically.%介绍了采用灰度传感器的自循迹小车的设计与实现,并加以追踪与避障的功能。采用与白色地面反差很大的黑色路线引导小车按既定路线前进,若接近开关检测到物体时,实现追踪功能。通过改编程序,同样利用这两个接近开关可实现避障功能,即遇到障碍物时,自动转弯。

  10. Mortalidad por cáncer en la persona adulta mayor de Costa Rica

    Directory of Open Access Journals (Sweden)

    Manrique Leal-Mateos

    2005-01-01

    Full Text Available Justificación y objetivo: El análisis de la mortalidad por cáncer en el adulto mayor continúa siendo una herramienta importante para identificar los factores de riesgo asociados. El presente estudio tiene como finalidad analizar la mortalidad por cáncer en las personas adultas mayores del país durante el año 2002. Métodos: Se realizó un estudio descriptivo de corte transversal. La fuente de información utilizada fue la base de datos del CCP-INEC, facilitada por los centros de documentación e información de estas mismas instituciones. Las variables estudiadas fueron: edad, sexo y lugar de residencia de cada persona fallecida. Además, se registró la localización anatómica de los tumores con base en la clasificación internacional de enfermedades (CIE-10. Mediante el ajuste directo de tasas de analizó la mortalidad por provincia. Resultados: Durante el año 2002, se registraron 3 167 muertes por cáncer en el país. De estas, 1 960 (61,8% ocurrieron en personas mayores de 65 años. El 58,2% (n = 1141 afectaron al sexo masculino. El cáncer de próstata presentó la tasa más alta de mortalidad. Al calcular las tasas de mortalidad ajustada para cada provincia, se observó que Cartago presentó la tasa más alta. Discusión: El 61, 8% del total de muertes por cáncer en el país ocurren en la población adulta mayor. Este resultado resulta importante si consideramos el costo que representa para los servicios de salud la atención de este tipo de pacientes. El riesgo de fallecer por cáncer es considerablemente superior después de los 65 años. Por tanto, la disminución de la mortalidad debe realizarse por medio de programas preventivos de menor costo y que se desarrollen en edades tempranas.Objective: Cancer mortality analysis in elderlys is still an important tool to identify associated risk factors. The goal of the present study is the analysis of mortality due to cancer in older adults during the year 2002 in Costa Rica. Methods

  11. Classification and regression tree (CART model to predict pulmonary tuberculosis in hospitalized patients

    Directory of Open Access Journals (Sweden)

    Aguiar Fabio S

    2012-08-01

    Full Text Available Abstract Background Tuberculosis (TB remains a public health issue worldwide. The lack of specific clinical symptoms to diagnose TB makes the correct decision to admit patients to respiratory isolation a difficult task for the clinician. Isolation of patients without the disease is common and increases health costs. Decision models for the diagnosis of TB in patients attending hospitals can increase the quality of care and decrease costs, without the risk of hospital transmission. We present a predictive model for predicting pulmonary TB in hospitalized patients in a high prevalence area in order to contribute to a more rational use of isolation rooms without increasing the risk of transmission. Methods Cross sectional study of patients admitted to CFFH from March 2003 to December 2004. A classification and regression tree (CART model was generated and validated. The area under the ROC curve (AUC, sensitivity, specificity, positive and negative predictive values were used to evaluate the performance of model. Validation of the model was performed with a different sample of patients admitted to the same hospital from January to December 2005. Results We studied 290 patients admitted with clinical suspicion of TB. Diagnosis was confirmed in 26.5% of them. Pulmonary TB was present in 83.7% of the patients with TB (62.3% with positive sputum smear and HIV/AIDS was present in 56.9% of patients. The validated CART model showed sensitivity, specificity, positive predictive value and negative predictive value of 60.00%, 76.16%, 33.33%, and 90.55%, respectively. The AUC was 79.70%. Conclusions The CART model developed for these hospitalized patients with clinical suspicion of TB had fair to good predictive performance for pulmonary TB. The most important variable for prediction of TB diagnosis was chest radiograph results. Prospective validation is still necessary, but our model offer an alternative for decision making in whether to isolate patients with

  12. Tendência da mortalidade por neoplasias malignas selecionadas em Rio Branco, Acre, Brasil, 1980-2006

    Directory of Open Access Journals (Sweden)

    Juliano de Pádua Nakashima

    2011-06-01

    Full Text Available A distribuição temporal da incidência e mortalidade por câncer na Amazônia Ocidental é desconhecida. As tendências das taxas de mortalidade por câncer ajustadas por idade nas localizações anatômicas apresentando maior magnitude entre 1980-2006 em Rio Branco, Acre, Brasil, foram modelizadas por meio de regressão linear. A tendência temporal da mortalidade por câncer em homens revelou padrão de crescimento não constante, e estabilidade em mulheres. Ao final da série, as taxas mais elevadas em mulheres foram, em ordem decrescente, colo uterino, pulmão, fígado e vias biliares intra-hepáticas, estômago e mama. No sexo masculino, foram pulmão, próstata, fígado e vias biliares intra-hepáticas, estômago e esôfago. O padrão observado revela elevação na mortalidade por câncer de mama e pulmão em mulheres, declínio de câncer de colo uterino, pulmão em homens, e estômago em ambos os sexos. A elevada mortalidade por câncer de fígado merece destaque em decorrência das elevadas taxas de infecção pelo vírus da hepatite B e C no Acre.

  13. El gradiente socioeconómico de la mortalidad por tuberculosis en México (2004-2008

    Directory of Open Access Journals (Sweden)

    José Alejandro Meza-Palmeros

    2013-01-01

    Full Text Available Objetivo: Analizar la relación entre mortalidad por tuberculosis (TB y diversos indicadores de rezago social (pobreza alimentaria, ocupación, porcentaje de población hablante de una lengua indígena en México, durante el período 2004-2008. Metodología: Se conformó una base de datos con las defunciones registradas en el país por TB de 2004 a 2008 que incluyó: municipio, localidad de residencia y ocupación –tanto por sector económico (primario, secundario, terciario, como condición de empleado/desempleado- de los fallecidos; información relacionada con el grado de rezago social por localidad (porcentaje de población hablante de lengua indígena y por municipio (porcentaje de población en situación de pobreza alimentaria. Posteriormente se estimaron las tasas de mortalidad por TB según las variables mencionadas anteriormente. El análisis estadístico se realizó utilizando pruebas de chi cuadrada y regresión lineal. Resultados: Se encontró que la mortalidad por TB obedece a un gradiente socioeconómico que se expresa en una relación estadísticamente significativa entre la mortalidad por TB y los indicadores analizados (grado de rezago social, porcentaje de población indígena por localidad, sector económico de ocupación y, condición de empleado/desempleado. Conclusiones: La mortalidad por TB en México parece concentrarse en la población socialmente vulnerable, por lo que es necesario que en la estrategia de prevención y control de la TB se consideren en mayor medida, los determinantes sociales de la enfermedad.

  14. Desigualdades en mortalidad prematura según indicadores de bienestar material en Navarra: estudio poblacional de seguimiento 2001-2008

    Directory of Open Access Journals (Sweden)

    E. Miqueleiz

    Full Text Available Fundamento. Mostrar las desigualdades en mortalidad prematura según indicadores de bienestar material en Navarra. Método. Todos los ciudadanos menores de 75 años residentes en Navarra en 2001 fueron seguidos durante 7 años para conocer su estado vital. El indicador de posición socioeconómica usado ha sido la superficie de la casa y el número de vehículos del hogar. Se han estimado las tasas de mortalidad general y por causa de muerte ajustadas por edad según estos indicadores. Resultados. La razón de tasas por todas las causas de muerte en las categorías inferiores es según la superficie de la vivienda de 1,14 (IC 95%: 1,05-1,24 y 1,25 (IC 95%: 1,18-1,32 en mujeres y hombres respectivamente y de 1,46 (IC 95%: 1,36-1,57 y 1,97 (IC 95%: 1,89-2,05 según el número de vehículos. El sida es la causa de muerte que presenta una mayor diferencia en las tasas de mortalidad entre las personas con menor y mayor bienestar material. Otras causas de muerte con elevada diferencia en las tasas de mortalidad son las enfermedades digestivas y la diabetes mellitus en mujeres y las enfermedades del aparato digestivo y respiratorio en hombres. Conclusiones. La tasa de mortalidad en la población navarra muestra un gradiente inverso con el bienestar material, a excepción de algunas localizaciones de cáncer. Este gradiente es mayor entre los hombres que entre las mujeres.

  15. El gradiente socioeconómico de la mortalidad por tuberculosis en México (2004-2008

    Directory of Open Access Journals (Sweden)

    José Alejandro Meza-Palmeros

    2013-01-01

    Full Text Available Objetivo: Analizar la relación entre mortalidad por tuberculosis (TB y diversos indicadores de rezago social (pobreza alimentaria, ocupación, porcentaje de población hablante de una lengua indígena en México, durante el período 2004-2008. Metodología utilizada: Se conformó una base de datos con las defunciones registradas en el país por TB de 2004 a 2008 que incluyó: municipio, localidad de residencia y ocupación –tanto por sector económico (primario, secundario, terciario, como condición de empleado/desempleado- de los fallecidos; información relacionada con el grado de rezago social por localidad (porcentaje de población hablante de lengua indígena y por municipio (porcentaje de población en situación de pobreza alimentaria. Posteriormente se estimaron las tasas de mortalidad por TB según las variables mencionadas anteriormente. El análisis estadístico se realizó utilizando pruebas de chi cuadrada y regresión lineal. Resultados: Se encontró que la mortalidad por TB obedece a un gradiente socioeconómico que se expresa en una relación estadísticamente significativa entre la mortalidad por TB y los indicadores analizados (grado de rezago social, porcentaje de población indígena por localidad, sector económico de ocupación y, condición de empleado/desempleado. Conclusiones: La mortalidad por TB en México parece concentrarse en la población socialmente vulnerable, por lo que es necesario que en la estrategia de prevención y control de la TB se consideren en mayor medida, los determinantes sociales de la enfermedad.

  16. Electrophysiological characteristics of paraventricular thalamic (PVT) neurons in response to cocaine and cocaine- and amphetamine-regulated transcript (CART).

    Science.gov (United States)

    Yeoh, Jiann Wei; James, Morgan H; Graham, Brett A; Dayas, Christopher V

    2014-01-01

    Recent work has established that the paraventricular thalamus (PVT) is a central node in the brain reward-seeking pathway. This role is mediated in part through projections from hypothalamic peptide transmitter systems such as cocaine- and amphetamine-regulated transcript (CART). Consistent with this proposition, we previously found that inactivation of the PVT or infusions of CART into the PVT suppressed drug-seeking behavior in an animal model of contingent cocaine self-administration. Despite this work, few studies have assessed how the basic physiological properties of PVT neurons are influenced by exposure to drugs such as cocaine. Further, our previous work did not assess how infusions of CART, which we found to decrease cocaine-seeking, altered the activity of PVT neurons. In the current study we address these issues by recording from anterior PVT (aPVT) neurons in acutely prepared brain slices from cocaine-treated (15 mg/ml, n = 8) and saline-treated (control) animals (n = 8). The excitability of aPVT neurons was assessed by injecting a series of depolarizing and hyperpolarizing current steps and characterizing the resulting action potential (AP) discharge properties. This analysis indicated that the majority of aPVT neurons exhibit tonic firing (TF), and initial bursting (IB) consistent with previous studies. However, we also identified PVT neurons that exhibited delayed firing (DF), single spiking (SS) and reluctant firing (RF) patterns. Interestingly, cocaine exposure significantly increased the proportion of aPVT neurons that exhibited TF. We then investigated the effects of CART on excitatory synaptic inputs to aPVT neurons. Application of CART significantly suppressed excitatory synaptic drive to PVT neurons in both cocaine-treated and control recordings. This finding is consistent with our previous behavioral data, which showed that CART signaling in the PVT negatively regulates drug-seeking behavior. Together, these studies suggest that cocaine

  17. The Effects of Direction of Exertion, Path, and Load Placement in Nursing Cart Pushing and Pulling Tasks: An Electromyographical Study.

    Science.gov (United States)

    Kao, Huei Chu; Lin, Chiuhsiang Joe; Lee, Yung Hui; Chen, Su Huang

    2015-01-01

    The purpose of this study was to explore the effects of direction of exertion (DOE) (pushing, pulling), path (walking in a straight line, turning left, walking uphill), and load placement (LP) (the 18 blocks were indicated by X, Y and Z axis; there were 3 levels on the X axis, 2 levels on the Y axis, and 3 levels on the Z axis) on muscle activity and ratings of perceived exertion in nursing cart pushing and pulling tasks. Ten participants who were female students and not experienced nurses were recruited to participate in the experiment. Each participant performed 108 experimental trials in the study, consisting of 2 directions of exertion (push and pull), 3 paths, and 18 load placements (indicated by X, Y and Z axes). A 23kg load was placed into one load placement. The dependent variables were electromyographic (EMG) data of four muscles collected bilaterally as follows: Left (L) and right (R) trapezius (TR), flexor digitorum superficialis (FDS), extensor digitorum (ED), and erector spinae (ES) and subjective ratings of perceived exertion (RPE). Split-split-plot ANOVA was conducted to analyze significant differences between DOE, path, and LP in the EMG and RPE data. Pulling cart tasks produced a significantly higher activation of the muscles (RTR:54.4%, LTR:50.3%, LFDS:57.0%, LED:63.4%, RES:40.7%, LES:36.7%) than pushing cart tasks (RTR:42.4%, LTR:35.1%, LFDS:32.3%, LED:55.1%, RES:33.3%, LES:32.1%). A significantly greater perceived exertion was found in pulling cart tasks than pushing cart tasks. Significantly higher activation of all muscles and perceived exertion were observed for walking uphill than walking in a straight line and turning left. Significantly lower muscle activity of all muscles and subject ratings were observed for the central position on the X axis, the bottom position on the Y axis, and the posterior position on the Z axis. These findings suggest that nursing staff should adopt forward pushing when moving a nursing cart, instead of backward

  18. The Effects of Direction of Exertion, Path, and Load Placement in Nursing Cart Pushing and Pulling Tasks: An Electromyographical Study.

    Directory of Open Access Journals (Sweden)

    Huei Chu Kao

    Full Text Available The purpose of this study was to explore the effects of direction of exertion (DOE (pushing, pulling, path (walking in a straight line, turning left, walking uphill, and load placement (LP (the 18 blocks were indicated by X, Y and Z axis; there were 3 levels on the X axis, 2 levels on the Y axis, and 3 levels on the Z axis on muscle activity and ratings of perceived exertion in nursing cart pushing and pulling tasks. Ten participants who were female students and not experienced nurses were recruited to participate in the experiment. Each participant performed 108 experimental trials in the study, consisting of 2 directions of exertion (push and pull, 3 paths, and 18 load placements (indicated by X, Y and Z axes. A 23kg load was placed into one load placement. The dependent variables were electromyographic (EMG data of four muscles collected bilaterally as follows: Left (L and right (R trapezius (TR, flexor digitorum superficialis (FDS, extensor digitorum (ED, and erector spinae (ES and subjective ratings of perceived exertion (RPE. Split-split-plot ANOVA was conducted to analyze significant differences between DOE, path, and LP in the EMG and RPE data. Pulling cart tasks produced a significantly higher activation of the muscles (RTR:54.4%, LTR:50.3%, LFDS:57.0%, LED:63.4%, RES:40.7%, LES:36.7% than pushing cart tasks (RTR:42.4%, LTR:35.1%, LFDS:32.3%, LED:55.1%, RES:33.3%, LES:32.1%. A significantly greater perceived exertion was found in pulling cart tasks than pushing cart tasks. Significantly higher activation of all muscles and perceived exertion were observed for walking uphill than walking in a straight line and turning left. Significantly lower muscle activity of all muscles and subject ratings were observed for the central position on the X axis, the bottom position on the Y axis, and the posterior position on the Z axis. These findings suggest that nursing staff should adopt forward pushing when moving a nursing cart, instead of

  19. Electrophysiological characteristics of paraventricular thalamic (PVT) neurons in response to cocaine and cocaine- and amphetamine-regulated transcript (CART)

    Science.gov (United States)

    Yeoh, Jiann Wei; James, Morgan H.; Graham, Brett A.; Dayas, Christopher V.

    2014-01-01

    Recent work has established that the paraventricular thalamus (PVT) is a central node in the brain reward-seeking pathway. This role is mediated in part through projections from hypothalamic peptide transmitter systems such as cocaine- and amphetamine-regulated transcript (CART). Consistent with this proposition, we previously found that inactivation of the PVT or infusions of CART into the PVT suppressed drug-seeking behavior in an animal model of contingent cocaine self-administration. Despite this work, few studies have assessed how the basic physiological properties of PVT neurons are influenced by exposure to drugs such as cocaine. Further, our previous work did not assess how infusions of CART, which we found to decrease cocaine-seeking, altered the activity of PVT neurons. In the current study we address these issues by recording from anterior PVT (aPVT) neurons in acutely prepared brain slices from cocaine-treated (15 mg/ml, n = 8) and saline-treated (control) animals (n = 8). The excitability of aPVT neurons was assessed by injecting a series of depolarizing and hyperpolarizing current steps and characterizing the resulting action potential (AP) discharge properties. This analysis indicated that the majority of aPVT neurons exhibit tonic firing (TF), and initial bursting (IB) consistent with previous studies. However, we also identified PVT neurons that exhibited delayed firing (DF), single spiking (SS) and reluctant firing (RF) patterns. Interestingly, cocaine exposure significantly increased the proportion of aPVT neurons that exhibited TF. We then investigated the effects of CART on excitatory synaptic inputs to aPVT neurons. Application of CART significantly suppressed excitatory synaptic drive to PVT neurons in both cocaine-treated and control recordings. This finding is consistent with our previous behavioral data, which showed that CART signaling in the PVT negatively regulates drug-seeking behavior. Together, these studies suggest that cocaine

  20. HISTORIAS DENTRO DEL HOSPITAL: TALLER DE ANIMACIÓN A LA LECTURA Y ESCRITURA EN EL AULA HOSPITALARIA RAMÓN Y CAJAL

    OpenAIRE

    RAMIREZ VEGA, CHENDA FRANCISCA

    2010-01-01

    El siguiente proyecto de innovación tiene como propósito contribuir a la mejora de la calidad de vida de los niños y adolescentes de entre 3 años a 16 años que presentan una enfermedad aguda o crónica que asisten al Aula Hospitalaria Ramón y Cajal. Se pretende contribuir a la mejora de la calidad de vida de estos niños y adolescentes durante su estadía en el Hospital, a través de la participación activa en las actividades del Taller de animación a la lectura y escritura "Historias dentr...

  1. Comunicación interna hospitalaria: una aproximación desde la creatividad/ Hospital internal communication : an approach from creativity

    Directory of Open Access Journals (Sweden)

    Pablo Medina Aguerrebere

    2015-07-01

    Full Text Available La gestión profesional de la comunicación institucional se ha convertido en una iniciativa estratégica para aquellos hospitales que desean crear una marca sólida. Para ello, la definición de la arquitectura de marca (identidad, valores, misión, visión, cultura e imagen y su difusión entre los stakeholders internos resulta fundamental. El objetivo de este artículo es reflexionar sobre el impacto que tiene la creatividad publicitaria en las acciones de comunicación interna que realiza un hospital para crear marca. Para ello, se realiza una revisión bibliográfica sobre la comunicación institucional hospitalaria, la comunicación interna y la creatividad publicitaria. El artículo concluye que la creatividad contribuye positivamente a dinamizar la comunicación interna del hospital y a crear una marca hospitalaria sólida. The professional management of corporate communication has become a strategic initiative to those hospitals that wish to create a strong brand. To do this, the definition of brand architecture (identity, values, mission, vision, culture and image and its dissemination among internal stakeholders is essential. This paper aims to reflect on the impact of advertising creativity in internal communication actions that takes a hospital to create brand. For this, a literature review on hospital corporate communication, internal communication and advertising creativity is performed. This paper concludes that creativity contributes positively to energize the hospital internal communication and create a strong brand

  2. A mortalidade neonatal em 1998, no município de Botucatu - SP La mortalidad neonatal en 1998, en el município de Botucatu-SP The neonatal mortality in 1998 at the municipality of Botucatu-SP

    Directory of Open Access Journals (Sweden)

    Kátia Poles

    2000-07-01

    Full Text Available Considerando que a mortalidade neonatal é indicador da qualidade da assistência prestada à gestante, ao parto e ao recém-nascido, realizamos o presente trabalho, cujo objetivo foi identificar as causas e o índice de mortalidade neonatal durante o ano de 1998 em Botucatu-SP. O coeficiente de mortalidade neonatal obtido foi de 8,3/1000 nascidos vivos e o coeficiente de mortalidade neonatal precoce foi de 7,3/1000 nascidos vivos, confirmando a importância dos óbitos na primeira semana de vida. Aproximadamente três quartos dos óbitos puderam ser classificados como reduzíveis por diagnóstico e tratamento precoces, reduzíveis por adequada atenção ao parto ou parcialmente reduzíveis por adequado controle da gravidez, evidenciando que para se reduzir os índices de morte neonatal, deveremos investir na melhoria da qualidade da assistência prestada à gestante, à parturiente e ao neonato.Considerando que la mortalidad neonatal es un indicador de la calidad de la asistencia ofrecida en la gestación, al parto y al recién- nacido, realizamos el presente trabajo, con el objetivo de estudiar la mortalidad neonatal durante el año de 1998 en Botucatu-SP. El coeficiente de mortalidad neonatal encontrado fue 8,3/1000 nacidos vivos y el coeficiente de mortalidad neonatal precoz fue de 7,3/1000 nacidos vivos, confirmando la importancia de las defunciones en la primera semana de vida. Los resultados mostraron que aproximadamente tres cuartos de las defunciones pueden ser reducidas con el control del embarazo, con el diagnóstico y tratamiento precoz o con la adecuada atención al parto, evidenciando que para reducir los índices de mortalidad neonatal, deberemos invertir en la mejoría de la calidad de la asistencia ofrecida en la gestación, en el parto y al recién-nacido.Considering that neonatal mortality is an indicator of the quality of the care provided to pregnant women, at childbirth as well as to the new born, authors developed the

  3. Experiments to Determine Whether Recursive Partitioning (CART) or an Artificial Neural Network Overcomes Theoretical Limitations of Cox Proportional Hazards Regression

    Science.gov (United States)

    Kattan, Michael W.; Hess, Kenneth R.; Kattan, Michael W.

    1998-01-01

    New computationally intensive tools for medical survival analyses include recursive partitioning (also called CART) and artificial neural networks. A challenge that remains is to better understand the behavior of these techniques in effort to know when they will be effective tools. Theoretically they may overcome limitations of the traditional multivariable survival technique, the Cox proportional hazards regression model. Experiments were designed to test whether the new tools would, in practice, overcome these limitations. Two datasets in which theory suggests CART and the neural network should outperform the Cox model were selected. The first was a published leukemia dataset manipulated to have a strong interaction that CART should detect. The second was a published cirrhosis dataset with pronounced nonlinear effects that a neural network should fit. Repeated sampling of 50 training and testing subsets was applied to each technique. The concordance index C was calculated as a measure of predictive accuracy by each technique on the testing dataset. In the interaction dataset, CART outperformed Cox (P less than 0.05) with a C improvement of 0.1 (95% Cl, 0.08 to 0.12). In the nonlinear dataset, the neural network outperformed the Cox model (P less than 0.05), but by a very slight amount (0.015). As predicted by theory, CART and the neural network were able to overcome limitations of the Cox model. Experiments like these are important to increase our understanding of when one of these new techniques will outperform the standard Cox model. Further research is necessary to predict which technique will do best a priori and to assess the magnitude of superiority.

  4. Later cART Initiation in Migrant Men from Sub-Saharan Africa without Advanced HIV Disease in France

    Science.gov (United States)

    de Monteynard, Laure-Amélie; Dray-Spira, Rosemary; de Truchis, Pierre; Grabar, Sophie; Launay, Odile; Meynard, Jean-Luc; Khuong-Josses, Marie-Aude; Gilquin, Jacques; Rey, David; Simon, Anne; Pavie, Juliette; Mahamat, Aba; Matheron, Sophie; Costagliola, Dominique; Abgrall, Sophie

    2015-01-01

    Objective To compare the time from entry into care for HIV infection until combination antiretroviral therapy (cART) initiation between migrants and non migrants in France, excluding late access to care. Methods Antiretroviral-naïve HIV-1-infected individuals newly enrolled in the FHDH cohort between 2002–2010, with CD4 cell counts >200/μL and no previous or current AIDS events were included. In three baseline CD4 cell count strata (200–349, 350-499, ≥500/μL), we examined the crude time until cART initiation within three years after enrolment according to geographic origin, and multivariable hazard ratios according to geographic origin, gender and HIV-transmission group, with adjustment for baseline age, enrolment period, region of care, plasma viral load, and HBV/HBC coinfection. Results Among 13338 individuals, 9605 (72.1%) were French natives (FRA), 2873 (21.4%) were migrants from sub-Saharan Africa/non-French West Indies (SSA/NFW), and 860 (6.5%) were migrants from other countries. Kaplan-Meier probabilities of cART initiation were significantly lower in SSA/NFW than in FRA individuals throughout the study period, regardless of the baseline CD4 stratum. After adjustment, the likelihood of cART initiation was respectively 15% (95%CI, 1–28) and 20% (95%CI, 2–38) lower in SSA/NFW men than in FRA men who had sex with men (MSM) in the 350-499 and ≥500 CD4 strata, while no difference was observed between other migrant groups and FRA MSM. Conclusion SSA/NFW migrant men living in France with CD4 >350/μL at entry into care are more likely to begin cART later than FRA MSM, despite free access to treatment. Administrative delays in obtaining healthcare coverage do not appear to be responsible. PMID:25734445

  5. Differences in CART expression and cell cycle behavior discriminate sympathetic neuroblast from chromaffin cell lineages in mouse sympathoadrenal cells.

    Science.gov (United States)

    Chan, Wing Hei; Gonsalvez, David G; Young, Heather M; Southard-Smith, E Michelle; Cane, Kylie N; Anderson, Colin R

    2016-02-01

    Adrenal medullary chromaffin cells and peripheral sympathetic neurons originate from a common sympathoadrenal (SA) progenitor cell. The timing and phenotypic changes that mark this lineage diversification are not fully understood. The present study investigated the expression patterns of phenotypic markers, and cell cycle dynamics, in the adrenal medulla and the neighboring suprarenal ganglion of embryonic mice. The noradrenergic marker, tyrosine hydroxylase (TH), was detected in both presumptive adrenal medulla and sympathetic ganglion cells, but with significantly stronger immunostaining in the former. There was intense cocaine and amphetamine-regulated transcript (CART) peptide immunostaining in most neuroblasts, whereas very few adrenal chromaffin cells showed detectable CART immunostaining. This phenotypic segregation appeared as early as E12.5, before anatomical segregation of the two cell types. Cell cycle dynamics were also examined. Initially, 88% of Sox10 positive (+) neural crest progenitors were proliferating at E10.5. Many SA progenitor cells withdrew from the cell cycle at E11.5 as they started to express TH. Whereas 70% of neuroblasts (TH+/CART+ cells) were back in the cell cycle at E12.5, only around 20% of chromaffin (CART negative) cells were in the cell cycle at E12.5 and subsequent days. Thus, chromaffin cell and neuroblast lineages showed differences in proliferative behavior from their earliest appearance. We conclude that the intensity of TH immunostaining and the expression of CART permit early discrimination of chromaffin cells and sympathetic neuroblasts, and that developing chromaffin cells exhibit significantly lower proliferative activity relative to sympathetic neuroblasts.

  6. Analysis of sequence variability in the pig CART gene and association of polymorphism with fatness traits in a F2 population.

    Science.gov (United States)

    Zhu, Xiaoping; Mo, Delin; Wang, Chong; Liu, Xiaohong; Li, Jiaqi; Ling, Fei; Chen, Yaosheng

    2014-08-01

    CART (cocaine- and amphetamine-regulated transcript) peptides are neuromodulators that are involved in appetite control and energy homeostasis. It can inhibit food intake and reduce body weight that have received much attention, but a direct and comprehensive relationship with pigs differing in fatness which could be applied to breeding well has not been established. This study aims to search for polymorphism within the porcine CART gene and evaluate the effect of specific genotypes with regards to an association with fatness traits in a F2 population consisting of 230 individuals. Screening of 2264 bp DNA fragment covering the entire CART gene revealed 29 mutations and four indels (insertion or a deletion), in which four unlinked SNPs (single-nucleotide polymorphisms) could be digested by enzymes and subsequently genotyped in two purebreds and a F2 population. Landrace (lean-type), one of purebreds, presented significantly higher CART expression level than Lantang (obese-type) in most tissues studied. Association analysis revealed that three SNPs (T415C, C640T and C847T) displayed significantly association (p CART expression among individuals with different genotypes, and the individuals with lower average live backfat thickness (BFAW) expressed CART protein at a bit higher level than others. Our study screened and mapped the genetic variations in the porcine CART gene, and confirmed three functional SNPs which are promising molecular markers for pig production traits.

  7. Infecção hospitalar: estudo de prevalência em um hospital público de ensino Infección hospitalaria: estúdio de prevaléncia en un hospital público y de enseñanza Nosocomial infection: study of prevalence at a public teaching hospital

    Directory of Open Access Journals (Sweden)

    Maria Eliete Batista Moura

    2007-08-01

    Full Text Available Este estudo objetivou determinar a prevalência de infecção hospitalar (IH e distribuição por topografia e por microorganismo e suas sensibilidades antimicrobianas. Realizado em duas Unidades de Terapia Intensiva (UTIs de um hospital público de ensino de Teresina, com amostragem de 394 casos de IH e processados pelo Software SPSS. A infecção respiratória foi a maior prevalência (61,26% na UTI Geral. Evidenciou-se maior sensibilidade bacteriana à amicacina (52,48 na UTI do SPS. O microorganismo com maior prevalência foi a Klebsiella pneumonia (35,46% na UTI geral. Conclui-se que a prevalência de IH nas duas UTIs foi de 60,8%, ultrapassando 45,3 % do índice geral registrado nos hospitais brasileiros que é 15,5%, contribuindo para aumentar a morbi - mortalidade causadas por infecções.Este estudio tiene como objetivo determinar la superioridad de infección hospitalaria (IH y distribución por topografía, por microorganismos y sus sensibilidades antimicrobianas. Realizado en dos Unidades de Terapia Intensiva (UTIS de un hospital público de enseñanza de Teresina, con muestra de 394 casos de IH y procesados con Software SPSS. La infección respiratória mostró mayor superioridad (61,26% en la UTI General. Evidenció mayor sensibilidad bacteriana al amicacina (52,48% en la UTI del SPS. El microorganismo con mayor superioridad fue Klebsiella neumonía (35,46% en la UTI general. Como concluye, la superioridad de IH en las dos UTIS fue 60,8%, sobrepasando 45,3 % del índice general registrado en hospitales brasileños que es 15,5%, contribuyendo para aumentar a morbi - mortalidad causadas por infecciones.This study aimed to determine the prevalence of nosocomial infection (NI and distribution for topography and microorganism and its antimicrobial sensibility. The study was carried out in two Intensive Care Units (ICUs of a public teaching hospital of Teresina, with sampling of 394 NI cases and processed by the SPSS Software. The

  8. Development of Prediction Model for Endocrine Disorders in the Korean Elderly Using CART Algorithm

    Directory of Open Access Journals (Sweden)

    Haewon Byeon

    2015-09-01

    Full Text Available The aim of the present cross-sectional study was to analyze the factors that affect endocrine disorders in the Korean elderly. The data were taken from the A Study of the Seoul Welfare Panel Study 2010. The subjects were 2111 people (879 males, 1,232 females aged 60 and older living in the community. The dependent variable was defined as the prevalence of endocrine disorders. The explanatory variables were gender, level of education, household income, employment status, marital status, drinking, smoking, BMI, subjective health status, physical activity, experience of stress, and depression. In the Classification and Regression Tree (CART algorithm analysis, subjective health status, BMI, education level, and household income were significantly associated with endocrine disorders in the Korean elderly. The most preferentially involved predictor was subjective health status. The development of guidelines and health education to prevent endocrine disorders is required for taking multiple risk factors into account.

  9. Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART

    Science.gov (United States)

    Anzinger, Joshua J.; Butterfield, Tiffany R.; Angelovich, Thomas A.; Crowe, Suzanne M.; Palmer, Clovis S.

    2014-01-01

    Combined antiretroviral therapy (cART) extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly. Although T-cell activation has been extensively examined in the context of cART-treated HIV infection, monocyte activation is only beginning to be recognized as an important source of inflammation in this context. Here we examine markers and sources of monocyte activation during cART-treated HIV infection and discuss the role of monocytes during cardiovascular disease, HIV-associated neurocognitive disorder, and innate immune aging. PMID:25025081

  10. Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART

    Directory of Open Access Journals (Sweden)

    Joshua J. Anzinger

    2014-01-01

    Full Text Available Combined antiretroviral therapy (cART extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly. Although T-cell activation has been extensively examined in the context of cART-treated HIV infection, monocyte activation is only beginning to be recognized as an important source of inflammation in this context. Here we examine markers and sources of monocyte activation during cART-treated HIV infection and discuss the role of monocytes during cardiovascular disease, HIV-associated neurocognitive disorder, and innate immune aging.

  11. The Impact of Groupement des Cartes Bancaires on Competition Law Enforcement

    Directory of Open Access Journals (Sweden)

    Piero Fattori

    2015-10-01

    Full Text Available The Groupement des Cartes bancaires represents a key judgment for competition enforcement, as it provides helpful clarification on the notion of “restriction by object” and on the judicial standard of review of Commission decisions. As of the first aspect, the ruling limited the restrictions by object to those which by their very nature and on the basis of the experience reveal a sufficient degree of harm to competition. On the standard required to the Court in reviewing competition decisions, the ECJ underlines the necessity of carrying out a full review, specifying that the presence of economic issues should not dispense the Court with an in-depth review of the law and the facts. The principles expressed in the judgment could have a great impact also at national level, where it could provide useful guidance both to Italian competition authority and to the Administrative Courts.

  12. Indoor space 3D visual reconstruction using mobile cart with laser scanner and cameras

    Science.gov (United States)

    Gashongore, Prince Dukundane; Kawasue, Kikuhito; Yoshida, Kumiko; Aoki, Ryota

    2017-02-01

    Indoor space 3D visual reconstruction has many applications and, once done accurately, it enables people to conduct different indoor activities in an efficient manner. For example, an effective and efficient emergency rescue response can be accomplished in a fire disaster situation by using 3D visual information of a destroyed building. Therefore, an accurate Indoor Space 3D visual reconstruction system which can be operated in any given environment without GPS has been developed using a Human-Operated mobile cart equipped with a laser scanner, CCD camera, omnidirectional camera and a computer. By using the system, accurate indoor 3D Visual Data is reconstructed automatically. The obtained 3D data can be used for rescue operations, guiding blind or partially sighted persons and so forth.

  13. A Nocturnal Boundary Layer Simulation over the ARM-CART Site

    Science.gov (United States)

    Werth, D.; Leclerc, M.; Duarte, H.; Fischer, M.; Kurzeja, R.; Parker, M.

    2008-12-01

    The nocturnal boundary layer (NBL) is characterized by strong inversions and weak turbulent motions. It is during this time that low-level jets (LLJs) often form as the winds aloft reach speeds approaching 15-25m/s at levels below 1000m. During the daytime, turbulent mixing quickly damps such organized motion, but at night the surface cooling establishes an inversion which reduces turbulence and allows jets to form uninhibited. A field project over the ARM-CART site during a period of several nights in September, 2007 was conducted to explore the jet evolution. Data was collected from a tower and analyzed for turbulent behavior. With data limited to a single location, however, the full range of NBL behavior is difficult to determine. The Regional Atmospheric Modeling System (RAMS) is therefore used to simulate the ARM-CART NBL field experiment and validated against the data collected from the site. This model was run at high resolution, and is ideal for calculating the interactions among the various motions within the boundary layer and their influence on the surface. The model can provide information throughout the NBL - with a larger domain, a simulation of the NBL can provide information over a large range of locations and heights. In particular, we are interested in the way that the simulated NBL eddies are affected by their height and proximity to the LLJ, and how this compares to the tower results. The eddy sizes that exist in the model are limited by its grid spacing, but a series of smaller, finer nests allow us to study eddy motion at the relevant scales for short periods.

  14. Corticotropin-releasing hormone (CRH) stimulates cocaine- and amphetamine-regulated transcript gene (CART1) expression through CRH type 1 receptor (CRHR1) in chicken anterior pituitary.

    Science.gov (United States)

    Mo, Chunheng; Cai, Guoqing; Huang, Long; Deng, Qiuyang; Lin, Dongliang; Cui, Lin; Wang, Yajun; Li, Juan

    2015-12-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide(s) is generally viewed as neuropeptide(s) and can control food intake in vertebrates, however, our recent study revealed that CART1 peptide is predominantly expressed in chicken anterior pituitary, suggesting that cCART1 peptide is a novel pituitary hormone in chickens and its expression is likely controlled by hypothalamic factor(s). To test this hypothesis, in this study, we examined the spatial expression of CART1 in chicken anterior pituitary and investigated the effect of hypothalamic corticotropin-releasing hormone (CRH) on pituitary cCART1 expression. The results showed that: 1) CART1 is expressed in both caudal and cephalic lobes of chicken anterior pituitary, revealed by quantitative real-time PCR (qPCR), western blot and immuno-histochemical staining; 2) CRH potently stimulates cCART1 mRNA expression in cultured chick pituitary cells, as examined by qPCR, and this effect is blocked by CP154526 (and not K41498), an antagonist specific for chicken CRH type I receptor (cCRHR1), suggesting that cCRHR1 expressed on corticotrophs mediates this action; 3) the stimulatory effect of CRH on pituitary cCART1 expression is inhibited by pharmacological drugs targeting the intracellular AC/cAMP/PKA, PLC/IP3/Ca(2+), and MEK/ERK signaling pathways. This finding, together with the functional coupling of these signaling pathways to cCRHR1 expressed in CHO cells demonstrated by luciferase reporter assay systems, indicates that these intracellular signaling pathways coupled to cCRHR1 can mediate CRH action. Collectively, our present study offers the first substantial evidence that hypothalamic CRH can stimulate pituitary CART1 expression via activation of CRHR1 in a vertebrate species.

  15. Projection patterns of lateral hypothalamic, cocaine- and amphetamine-regulated transcript (CART) neurons to the dorsal raphe and/or the locus coeruleus in the rat.

    Science.gov (United States)

    Yoon, Ye S; Lee, Hyun S

    2013-02-04

    The present study was designed to reveal the projection patterns of lateral hypothalamic (LH), cocaine- and amphetamine-regulated transcript (CART) neurons to the dorsal raphe (DR) and/or the locus coeruleus (LC) in the rat. After the injection of Red or Green Retrobeads into the DR or LC, LH sections were immunostained for CART and/or melanin-concentrating hormone (MCH). First, CART-immunoreactive axon terminals formed close appositions to the DR (or LC) neuronal profiles. Second, a subpopulation of CART neurons containing MCH projected to the monoaminergic nuclei; the majority of labeled neurons were observed in the dorsal hypothalamic area, the dorsal part of the posterior hypothalamic area, and the zona incerta. Cells were also observed in the perifornical part of the LH, the dorsomedial hypothalamic nucleus, the peduncular and the magnocellular parts of the LH. Of the total population of DR (or LC)-projecting cells, CART/MCH co-containing neurons were 9.5% ± 1.6% (or 10.8% ± 1.3% for LC). Finally, a subset of CART (or MCH) neurons provided divergent axon collaterals to the DR and the LC. Of the entire CART (or MCH) cell population, 3.9% ± 0.8% (or 5.6% ± 1.0% for MCH) sent axon collaterals to the DR/LC. CART/MCH co-containing neurons projecting to the DR or LC might be involved in the feeding-related regulation of arousal, stress-related responses, and emotional behaviors. Thus, CART (or MCH) cells that send divergent axon collaterals to the DR/LC might have a simultaneous (and possibly more efficient) way to exert their specific influences on the aminergic nuclei.

  16. Effect of desipramine and citalopram treatment on forced swimming test-induced changes in cocaine- and amphetamine-regulated transcript (CART) immunoreactivity in mice.

    Science.gov (United States)

    Chung, Sung; Kim, Hee Jeong; Kim, Hyun Ju; Choi, Sun Hye; Kim, Jin Wook; Kim, Jeong Min; Shin, Kyung Ho

    2014-05-01

    Recent study demonstrates antidepressant-like effect of cocaine- and amphetamine-regulated transcript (CART) in the forced swimming test (FST), but less is known about whether antidepressant treatments alter levels of CART immunoreactivity (CART-IR) in the FST. To explore this possibility, we assessed the treatment effects of desipramine and citalopram, which inhibit the reuptake of norepinephrine and serotonin into the presynaptic terminals, respectively, on changes in levels of CART-IR before and after the test swim in mouse brain. Levels of CART-IR in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), and hypothalamic paraventricular nucleus (PVN) were significantly increased before the test swim by desipramine and citalopram treatments. This increase in CART-IR in the AcbSh, dBNST, and PVN before the test swim remained elevated by desipramine treatment after the test swim, but this increase in these brain areas returned to near control levels after test swim by citalopram treatment. Citalopram, but not desipramine, treatment increased levels of CART-IR in the central nucleus of the amygdala (CeA) and the locus ceruleus (LC) before the test swim, and this increase was returned to control levels after the test swim in the CeA, but not in the LC. These results suggest common and distinct regulation of CART by desipramine and citalopram treatments in the FST and raise the possibility that CART in the AcbSh, dBNST, and CeA may be involved in antidepressant-like effect in the FST.

  17. Crisis económica al inicio del siglo xxi y mortalidad en España. Tendencia e impacto sobre las desigualdades sociales. Informe SESPAS 2014

    Directory of Open Access Journals (Sweden)

    Miguel Ruiz-Ramos

    2014-06-01

    Full Text Available El objetivo de este estudio es analizar el impacto de la actual crisis económica en la evolución de la mortalidad en España y sus efectos sobre las desigualdades sociales en la mortalidad en Andalucía. Se han utilizado las defunciones procedentes de las estadísticas vitales del Instituto Nacional de Estadística para los años 1999 a 2011, así como la población correspondiente del padrón municipal de habitantes. Se calcularon tasas ajustadas de mortalidad general y específica por sexo y edad. Para estimar las tasas de mortalidad general y las razones de tasas según el nivel de estudios, entre 2002 y 2010 se utilizó la Base de Datos Longitudinal de Población de Andalucía (cohorte censal del 2001. Los porcentajes de cambio anuales y las tendencias se calcularon mediante regresión joinpoint. En España no se observa ningún cambio de tendencia significativo en la mortalidad a partir de 2008. Desde 1999 se mantiene una tendencia descendente, en ambos sexos y por todas las causas, excepto en las enfermedades del sistema nervioso. La mortalidad por accidentes de tráfico acelera su decrecimiento desde 2003. Los suicidios no modifican su tendencia negativa a lo largo del periodo. En Andalucía, las desigualdades sociales en la mortalidad general aumentaron en los hombres desde el inicio de la crisis, en el año 2008, fundamentalmente por un mayor descenso en la mortalidad en los de mayor nivel de estudios que en el resto, en un contexto de descenso de la mortalidad. En las mujeres no se observan cambios en el patrón de desigualdad.

  18. Proyecto de estudio y experimentación del cartón corrugado para su posterior inserción en el mercado

    OpenAIRE

    Cabrera Chiriboga, Alfredo Cabrera

    2009-01-01

    Contiene: Ecodiseño. Aspectos Ambientales de un producto. El ciclo de vida de un Producto. El Ecodiseño en el proceso de desarrollo de productos. Beneficios del Ecodiseño. El Reciclaje. Proceso de producción del cartón corrugado. El grupo simple cara (cara sencilla). Circuito del papel de ondular. Circuito de las caras. El grupo doble cara (o triple). Propiedades del cartón corrugado. Perfil de la onda o canal. Clasificación de los cartones. Exigencias en la fabricación del cartón corrugado. ...

  19. Classification and regression tree (CART analyses of genomic signatures reveal sets of tetramers that discriminate temperature optima of archaea and bacteria

    Directory of Open Access Journals (Sweden)

    Betsey Dexter Dyer

    2008-01-01

    Full Text Available Classification and regression tree (CART analysis was applied to genome-wide tetranucleotide frequencies (genomic signatures of 195 archaea and bacteria. Although genomic signatures have typically been used to classify evolutionary divergence, in this study, convergent evolution was the focus. Temperature optima for most of the organisms examined could be distinguished by CART analyses of tetranucleotide frequencies. This suggests that pervasive (nonlinear qualities of genomes may reflect certain environmental conditions (such as temperature in which those genomes evolved. The predominant use of GAGA and AGGA as the discriminating tetramers in CART models suggests that purine-loading and codon biases of thermophiles may explain some of the results.

  20. Reducción de la mortalidad materna por preeclampsia mediante la aplicación de un modelo biopsicosocial en Colombia

    OpenAIRE

    Herrera Murgueitio, Julián Alberto

    2013-01-01

    La pre-eclampsia es la causa más importante de mortalidad materna en los países en vías de desarrollo. Un programa integral de atención prenatal incluyendo componentes biopsicosociales fue desarrollado e introducido a nivel nacional en Colombia. Se describen las tendencias de las razones de mortalidad materna y sus causas relacionadas con el antes y después de la introducción de este programa. Métodos: Las razones de mortalidad materna general y específica fueron monitoreados durante trece añ...

  1. Efectos a corto plazo de la contaminación atmosférica sobre la mortalidad: resultados del proyecto EMECAM en Huelva, 1993-96

    Directory of Open Access Journals (Sweden)

    Daponte Codina Antonio

    1999-01-01

    Full Text Available FUNDAMENTO: El objetivo del estudio fue estimar la asociación entre los niveles de contaminación atmosférica y la mortalidad diaria en la ciudad de Huelva para el período 1993-1996 utilizando la metodología EMECAM. MÉTODOS: Se utilizaron como indicadores de mortalidad el número de muertos diarios por todas las causas menos externas, la mortalidad en sujetos mayores de 69 años, la mortalidad por enfermedades del aparato circulatorio y la mortalidad por enfermedades respiratorias. Se analizaron cuatro contaminantes, SO2, PM10, NO2, y CO, cuyos niveles diarios se obtuvieron de la red de vigilancia de la contaminación atmosférica en Huelva. Se construyeron modelos de regresión autoregresiva de Poisson controlando por tendencia, estacionalidad, temperatura, humedad, gripe, y eventos inusuales. RESULTADOS: Para la mortalidad por todas las causas se halló un efecto significativo del NO2 para todo el período (RR10m gr/m³: 1,0414; IC95%: 1,0047-1,0794 y de las partículas (PM10 para el semestre frío (RR10 m gr/m³: 1,0358;IC95%:1,0007 -1,0722. Para la mortalidad en mayores de 69 años se obtuvo una asociación significativa con el SO2 para todo el período (RR10 m gr/m³: 1,0606; IC95%:1,0020-1,1227. Se halló una asociación significativa para la mortalidad por enfermedades respiratorias con las partículas (PM10 en el semestre frío (RR10 m gr/m³: 1,1412; IC95%:1,0300 -1,2644. No se obtuvieron asociaciones significativas para la mortalidad por enfermedades del aparato circulatorio con ningún contaminantes, ni tampoco se observó ningún efecto significativo de los niveles de CO en los indicadores de mortalidad. CONCLUSIONES: En Huelva se han encontrado asociaciones significativas entre los niveles actuales de contaminación atmosférica por partículas, SO2, y NO2, y la mortalidad diaria. El efecto de estos contaminantes sobre la mortalidad es coherente con la literatura científica, aunque en el caso de Huelva, el escaso número de

  2. MORTALIDAD Y RECLUTAMIENTO DE ÁRBOLES EN UN BOSQUE PLUVIAL TROPICAL DE CHOCÓ (COLOMBIA) MORTALITY AND RECRUITMENT OF TREES IN A TROPICAL RAIN FOREST OF CHOCÓ (COLOMBIA)

    OpenAIRE

    Harley Quinto Mosquera; Reimer Rengifo Ibargüen; Yan Arley Ramos Palacios

    2009-01-01

    Se calcularon las tasas de mortalidad y reclutamiento de árboles en una parcela permanente de investigación de un bosque pluvial tropical. El estudio se basó en dos mediciones, una realizada en el año 1998 y la otra en el 2005, en las cuales se midió el diámetro (DAP) a todos los árboles con DAP>10 cm y se censaron los individuos muertos y reclutados. Se determinaron los tipos de mortalidad y se calculó el coeficiente de mortalidad, el coeficiente de reclutamiento exponencial, la biomasa aére...

  3. Efecto protector del apoyo social en la mortalidad en población anciana: un estudio longitudinal

    Directory of Open Access Journals (Sweden)

    Nebot Manel

    2002-01-01

    Full Text Available Fundamentos: El objetivo principal del estudio es analizar la relación entre el apoyo social y la mortalidad en una cohorte de población de 60 años o más, residente en Barcelona y no institucionalizada, observada durante el período de seguimiento de 1996 a 1999, con el objetivo de analizar la relación entre el apoyo social y la mortalidad en las personas que constituyen la cohorte. Métodos: En 1996 se realizó una entrevista telefónica a 755 personas (316 hombres y 439 mujeres que habían sido entrevistadas en la encuesta de salud de Barcelona de 1992, y que en ese año tenían 60 años o más. En el cuestionario se recogían variables socio-demográficas, de morbilidad y estado de salud, de apoyo social y de red social. Se han registrado los fallecimientos ocurridos entre 1996 y 1999. Se ha utilizado la regresión logística para analizar la asociación del apoyo social con la mortalidad. Resultados: El número de defunciones durante este período fue de 55 (5,9% de las mujeres y 9,2% de los hombres. Entre las variables que reflejan el apoyo social para los hombres, únicamente la situación de convivencia mostró en el análisis bivariado una asociación significativa con la mortalidad, que fue superior para los hombres que vivían con otros familiares pero no si vivían con su esposa o compañera (OR=3,7; IC 95% 1,4-9,6. Entre las mujeres, la existencia de apoyo vecinal, el tamaño de la red familiar, el número de contactos con la red comunitaria y la situación de convivencia se asociaron a la mortalidad en el análisis bivariado, aunque en la regresión logística multivariada, únicamente el apoyo vecinal (OR=3,6; IC:1,1-11,1 mantuvo una asociación significativa. Conclusiones: Los resultados muestran una asociación de las variables de apoyo social con la mortalidad. La relación entre las diversas variables de apoyo social, y los posibles mecanismos de prevención deberían ser abordados en futuros estudios.

  4. Comparacao dos criterios RIFLE, AKIN e KDIGO quanto a capacidade de predicao de mortalidade em pacientes graves

    Directory of Open Access Journals (Sweden)

    Talita Machado Levi

    2013-12-01

    Full Text Available Objetivo: A lesão renal aguda é uma complicação comum em pacientes gravemente enfermos, sendo os critérios RIFLE, AKIN e KDIGO utilizados para sua classificação. Esse trabalho teve como objetivo a comparação dos critérios citados quanto à capacidade de predição de mortalidade em pacientes gravemente enfermos. Métodos: Estudo de coorte prospectiva, utilizando como fonte de dados prontuários médicos. Foram incluídos todos os pacientes admitidos na unidade de terapia intensiva. Os critérios de exclusão foram tempo de internamento menor que 24 horas e doença renal crônica dialítica. Os pacientes foram acompanhados até a alta ou óbito Para análise dos dados, foram utilizados os testes t de Student, qui-quadrado, regressão logística multivariada e curva ROC. Resultados: A média de idade foi de 64 anos, com mulheres e afrodescendentes representando maioria. Segundo o RIFLE, a taxa de mortalidade foi de 17,74%, 22,58%, 24,19% e 35,48% para pacientes sem lesão renal aguda e em estágios Risk, Injury e Failure, respectivamente. Quanto ao AKIN, a taxa de mortalidade foi de 17,74%, 29,03%, 12,90% e 40,32% para pacientes sem lesão renal aguda, estágio I, estágio II e estágio III, respectivamente. Considerando o KDIGO 2012, a taxa de mortalidade foi de 17,74%, 29,03%, 11,29% e 41,94% para pacientes sem lesão renal aguda, estágio I, estágio II e estágio III, respectivamente. As três classificações apresentaram resultados de curvas ROC para mortalidade semelhantes. Conclusão: Os critérios RIFLE, AKIN e KDIGO apresentaram-se como boas ferramentas para predição de mortalidade em pacientes graves, não havendo diferença relevante entre os mesmos.

  5. Evolução da mortalidade infantil por causas evitáveis, Belo Horizonte, 1984-1998

    Directory of Open Access Journals (Sweden)

    Antônio Prates Caldeira

    2005-01-01

    Full Text Available OBJETIVO: Analisar a evolução da mortalidade infantil em região urbana com enfoque para o grupamento de causas evitáveis no período neonatal e pós-neonatal. MÉTODOS: O número de óbitos ocorridos na região metropolitana de Belo Horizonte, MG, foi obtido do Sistema de Informações em Mortalidade do Ministério da Saúde (SIM-MS e o número de nascidos vivos foi estimado a partir das estatísticas do registro civil da Fundação Instituto Brasileiro de Geografia e Estatística (IBGE, com correção dos registros atrasados de nascimentos. Utilizou-se modelo de regressão linear simples para estimar a tendência temporal das taxas de mortalidade infantil e seus componentes. A significância estatística da inclinação das curvas de regressão foi considerada para o nível p<0,05. RESULTADOS: Foi observado decréscimo da taxa de mortalidade infantil de 48,5 para 22,1 por mil nascidos vivos em toda a região. Entretanto, a queda mais acentuada foi observada nos últimos quatro anos da série. O componente pós-neonatal foi o principal responsável pelo declínio tanto na capital como nos demais municípios que compõem a região metropolitana de Belo Horizonte. CONCLUSÕES: Embora tenha sido observada para a região uma queda significativa da mortalidade infantil e particularmente da mortalidade pós-neonatal, esta última ainda se apresenta elevada em relação aos países desenvolvidos. As afecções perinatais e o grupamento diarréia-pneumonia-desnutrição representam importante potencial de redução. Discute-se o papel dos serviços de saúde na evitabilidade de tais óbitos.

  6. Incremento na mortalidade associada à presença de diabetes mellitus em nipo-brasileiros

    Directory of Open Access Journals (Sweden)

    Gimeno Suely Godoy A.

    1998-01-01

    Full Text Available OBJETIVO: Como parte de um estudo envolvendo migrantes japoneses (issei e seus descendentes (nisei, residentes na cidade de Bauru no Estado de São Paulo, descrevem-se e comparam-se os coeficientes de mortalidade (CM observados para o período de 1993 a 1996 em indivíduos com graus diferentes de tolerância à glicose. MATERIAL E MÉTODO: Nesse estudo, em 1993, a coorte era composta por 530 nipo-brasileiros (236 issei e 294 nisei, de ambos os sexos, com idade entre 40 e 79 anos, sendo que 91 indivíduos (17% foram classificados como diabéticos não dependentes de insulina (DMNDI, 90 (17% como portadores de tolerância à glicose diminuída (TGD e 349 (66% como normais quanto à tolerância à glicose. Em 1996 foram identificados os óbtos ocorridos e obtidas informações dos familiares e dos certificados de óbito para o registro da data e da causa da morte. Calcularam-se, para os três grupos de indivíduos, os CM brutos e ajustados, por todas as causas e por causas específicas (doenças circulatória e renal. O modelo de Cox foi utilizado para a comparação dos CM ajustados segundo idade, sexo, geração, creatinina sérica, presença de hipertensão arterial, de dislipidemia e de obesidade. RESULTADOS E CONCLUSÕES: As razões entre os CM brutos de indivíduos diabéticos e normais foram 2,95 (IC 95%: 1,10 -7,62 para os óbitos ocorridos por todas as causas e 4,75 (IC 95%: 1,31 - 16,48 para os óbitos por causas específicas. Não foram observadas diferenças estatisticamente significantes entre os CM brutos de indivíduos com TGD quando comparados aos indivíduos normais. Após o ajuste simultâneo pelas variáveis de controle, observou-se que, entre os indivíduos diabéticos, a força de mortalidade por causas específicas foi aproximadamente 4 vezes aquela observada entre os indivíduos normais (Razão dos CM: 3,86 e IC 95%: 1,11 -13,38. Os resultados em nipo-brasileiros são consistentes com outros obtidos em populações diab

  7. O que os dados de mortalidade do Censo de 2010 podem nos dizer? ¿Qué pueden decirnos los datos sobre mortalidad en el Censo de 2010? What can the mortality data from the 2010 Census tell us?

    OpenAIRE

    2012-01-01

    O Censo brasileiro de 2010 incluiu, em seu questionário, a pergunta sobre óbitos ocorridos no domicílio nos últimos 12 meses. Anteriormente, uma questão similar havia sido incluída na amostra do Censo de 1980, mas sendo pouco utilizada. O objetivo do artigo é fazer uma avaliação da qualidade da informação de mortalidade do Censo, em especial sobre a estrutura etária da mortalidade. Em relação à cobertura da enumeração dos óbitos, esta saltou de 40%, no Censo de 1980, para 80%, no de 2010. Os ...

  8. Mortalidade de bovinos zebuínos por hipotermia em Mato Grosso do Sul

    Directory of Open Access Journals (Sweden)

    Bethania S. Santos

    2012-03-01

    Full Text Available O presente trabalho teve por objetivo descrever a ocorrência periódica de mortalidade de bovinos por hipotermia após inversão térmica no estado de Mato Grosso do Sul. São relatados 16 surtos encaminhados ao Laboratório de Patologia Animal da FAMEZ/UFMS, ocorridos de agosto de 2000 a julho de 2010, em 13 municípios do Estado. O diagnóstico de hipotermia baseou-se na ocorrência de mortes após queda brusca de temperatura acompanhada de chuvas e ventos, simultaneamente em diversas propriedades, nos sinais clínicos observados e na ausência de lesões macro e microscópicas significativas. Em todos os surtos houve uma queda brusca de temperatura, de até 29ºC, em intervalos de um a quatro dias associada a chuva e vento. Na maioria das vezes a morte dos bovinos ocorreu em locais onde havia escassez de pasto e ausência de abrigos naturais ou artificiais. Os bovinos afetados estavam magros, com baixo escore corporal, e, em grande parte dos casos, eram encontrados mortos nos cantos das invernadas e próximos a cercas no dia seguinte à queda brusca da temperatura. Foram afetados bovinos de diferentes idades. Os sinais clínicos se caracterizavam por cegueira, incoordenação, dismetria, fraqueza, decúbito esternal, movimentos de pedalagem, opistótono, tremores musculares, e dificuldade respiratória e morte. Em 30 bovinos necropsiados os principais achados macroscópicos foram edema subcutâneo, cavitário e pulmonar, e, em alguns casos, histologicamente havia eosinofilia neuronal. A hipotermia é uma importante causa de mortalidade quando bovinos com pobre estado nutricional, pouca disponibilidade e qualidade dos pastos e ausência de abrigos naturais, são submetidos a uma condição de mudança climática com queda brusca de temperatura combinada com ventos fortes e chuvas.

  9. CART mRNA全CDS区序列的克隆与表达载体的构建%Cloning of the sequence of CDS region of pig CART mRNA and construction of the expression vector

    Institute of Scientific and Technical Information of China (English)

    李鹏飞; 李富禄; 于秀菊; 吕丽华

    2011-01-01

    选用猪为研究对象,以可卡因苯异丙胺调控转录肽(CART)作为影响猪繁殖机能的多肽,依据NCBI上登录的CARTmRNA序列设计3对特异性引物,用RT-PCR方法从下丘脑内扩增出CART mRNA的部分序列并进行序列分析;再根据扩增出的序列设计一对带酶切位点的特异性引物,用PCR方法扩增出含EcoR Ⅰ/HindⅢ酶切位点的CART mRNA的全编码序列(CDS)区序列.结果表明:猪下丘脑CART mRNA的CDS区全长367 bp,CART基因在下丘脑上有表达,并成功构建pEG-32a-CART原核表达载体.%Designing three pain specific primers based on the CART mRNA sequence included in NCBI GenBank, CART tnRNA sequences were amplified via RT-PCR from porcine hypothalamus tissue, and were analyzed. According to the amplified sequence, we designed a pair of expressing primers, amplified the whole coding sequence ( CDS) domain of CART including EcoR Ⅰ/Hind Ⅲ digestion sites. The results showed that; the length of CDS in porcine hypothalamus CART mRNA is 367 bp, CART gene can express in the hypothalamus, and it had successfully constructed prokaryotic expression vector of pEG-32a-CART.

  10. Mortalidade infantil: distribuição espacial no município de Goiânia

    OpenAIRE

    Carmen Luci Rodrigues Lopes; Leyla Yoko Harada; Mª José Pacheco Elias; Marília Dalva Turchi

    1995-01-01

    As autoras verificam a distribuição espacial do coeficiente de Mortalidade infantil nas diferentes áreas do Municipio de Goiânia: Estabelecem a reloção entre óbitos menores de 1 ano e os indicadores sócio-econômicos, nas diferentes áreas no Município de Goiânia no ano de 1992. Como também avaliam a influência das variáveis: sexo, idade, causa básica no perfil da mortalidade infantil em Goiânia. Este Trabalho tem o intuito de proporcionar subsídios que venham a contribuir nas propostas de açõe...

  11. Determinantes sociales de la mortalidad por enfermedad diarreica aguda en los menores de 5 años en Colombia

    OpenAIRE

    Reyes Pinto, Doris Yolima

    2015-01-01

    Antecedentes: Las Enfermedades Diarreicas son la segunda mayor causa de muerte infantil en el mundo, alrededor de 760.000 niños menores de cinco años cada año mueren por esta causa. En Colombia, la tasa de mortalidad por Enfermedad Diarreíca Aguda EDA en menores de cinco años pasó de 11.8 en 2009 a 7.34 muertes por 100.000 menores de cinco años en 2011. A pesar de este importante descenso, la mortalidad por EDA, que pudiese evitarse casí en su totalidad, continúa estando entre las primeras ca...

  12. Análisis comparativo de la mortalidad del médico en Costa Rica, 1950-2003

    Directory of Open Access Journals (Sweden)

    Mayra Cartín-Brenes

    2006-09-01

    Full Text Available Justificación y objetivo: En nuestro país, los médicos tienen la creencia de que, a causa del tipo de profesión que ejercen, gozan de una vida más corta y experimentan una mayor mortalidad que la población general. Existen pocas investigaciones realizadas que sugieran una sobremortalidad de los médicos y ninguna que realice un análisis comparativo con otros profesionales agremiados. Considerando que los recursos que se invierten para la formación de profesionales en el área son muy altos, la muerte prematura en este grupo implicaría un costo social muy elevado. En esta investigación se obtuvo y se analizó información de la mortalidad del médico en Costa Rica, para el período 1950 - 2003, por medio de la cual se permite conocer su comportamiento en el gremio médico nacional, en relación con el de otros profesionales y el de la población general. Métodos: Se comparó la población de médicos con la de farmacéuticos, abogados e ingenieros y arquitectos, durante el período en estudio. Se construyeron las bases de datos. Se caracterizaron las poblaciones y se analizó el comportamiento de la mortalidad en ellas a través de diferentes métodos estadísticos Resultados: En cuanto a los resultados más relevantes, se obtuvo que las cuatro poblaciones de profesionales son similares en cuanto a su crecimiento, medias de edad de incorporación (28 años y edad de muerte (58 años. No obstante, difieren en su distribución por sexo; conforme ha pasado el tiempo más mujeres se han incorporado en estas carreras. El porcentaje de muertes ocurridas antes de alcanzar la esperanza de vida respectiva fue similar en todos los grupos (~90%. La razón estandarizada de mortalidad (REM, es similar en los cuatro grupos y menor que la de la población general. La mortalidad ha disminuido a través del tiempo y el riesgo de morir en la actualidad es menor que en generaciones previas. La supervivencia entre los incorporados de 20 a 29 años, es

  13. Uso de la gammaglobulina intravenosa y sus efectos en la mortalidad por sepsis en niños

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    Izaida Montero López

    2014-08-01

    Full Text Available Se realizó una revisión sistemática sobre el uso de inmunoglobulina intravenosa y su efecto sobre la mortalidad en el niño menor de un año. Se analizaron artículos originales y revisiones sistemáticas realizadas en los últimos años acerca del tema; se incluyeron artículos originales publicados en los años 2002 al 2011 y las revisiones sistemáticas publicadas en los años 2007 al 2011, que resultaron en total siete. Se concluye que no existe un consenso en la prescripción de inmunoglobulina intravenosa en el tratamiento de la sepsis y aunque no existe reducción significativa de la mortalidad, se evidencia un mayor número de vidas salvadas en el grupo de pacientes con este tratamiento

  14. Fatores de risco para mortalidade neonatal no município de Serra, Espírito Santo

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    Eliane de Fátima Almeida Lima

    2012-08-01

    Full Text Available Objetivou-se analisar os fatores de risco associados à mortalidade neonatal no município de Serra, ES. Realizou-se estudo de coorte não concorrente, utilizando a técnica de Linkage que pareou os 32.275 nascidos vivos com 273 óbitos neonatais ocorridos no período de 2001 a 2005, utilizando-se dados do SINASC e SIM. Após os ajustes na regressão logística, os fatores associados à mortalidade foram: mães sem instrução, idade materna 35 anos, nascer em hospital público, nenhuma consulta de pré-natal, peso ao nascer.

  15. High incidence of intermittent care in HIV-1-infected patients in Curaçao before and after starting cART.

    Science.gov (United States)

    Hermanides, H S; Holman, R; Gras, L; Winkel, C N; Gerstenbluth, I; de Wolf, F; Duits, A J

    2013-01-01

    Retention in care is one of the major challenges to scaling up and maximizing the effectiveness of combination antiretroviral therapy (cART). High attrition rates have been reported in the Caribbean region, varying from 6% to 23%. We studied the incidence of and risk factors for intermittent care in a cohort of adult HIV-1-positive patients, who entered into care in Curaçao between January 2005 and July 2009. A total of 214 therapy-naïve HIV-1-infected patients aged 15 years or older, entered HIV care between January 2005 and July 2009. Intermittent care was defined as at least one period of 365 days or longer in which there was no HIV care contact in Curaçao. Cox regression models were used to identify characteristics associated with time to intermittent care. In all, 203 (95%) patients could be classified as having intermittent or continuous care. The incidence of intermittent care before starting cART was 25.4 per 100 person years observation (PYO), whilst it was 6.1 per 100 PYO after starting cART. Being born outside Curaçao was associated with intermittent care before and after starting cART. Time from diagnosis to entry into care was an independent predictor for intermittent care before starting cART. Younger age was independently associated with intermittent care after starting cART. Half of the patients returned to care after intermitting care. Upon returning to care, median CD4 count was 264 cells/mm(3) (IQR, 189-401) for those who intermitted care before starting cART, and 146 cells/mm(3) (IQR, 73-436) in those who intermitted care after starting cART. In conclusion, the incidence of intermitting care is high in Curaçao, especially before starting cART, and intermitting care before starting cART is an independent predictor for starting cART late.

  16. Evolução de indicadores socioeconômicos e da mortalidade cardiovascular em três estados do Brasil

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    Gabriel Porto Soares

    2013-02-01

    Full Text Available FUNDAMENTO: Doenças do aparelho circulatório são a primeira causa de morte no Brasil. OBJETIVO: Correlacionar taxas de mortalidade por doenças do aparelho circulatório nos Estados de Rio de Janeiro, São Paulo, Rio Grande do Sul, e em suas capitais, entre 1980 e 2008, com indicadores socioeconômicos coletados a partir de 1949. MÉTODOS: Populações e óbitos obtidos no Datasus/MS. Calcularam-se taxas de mortalidade por doenças isquêmicas do coração, doenças cerebrovasculares, causas mal definidas, doenças do aparelho circulatório (DApCirc e todas as causas, ajustadas pelo método direto e compensadas por causas mal definidas. Dados de mortalidade infantil foram obtidos nas secretarias estaduais e municipais de saúde e no IBGE. Dados de PIB e escolaridade foram obtidos no Ipea. As taxas de mortalidade e os indicadores socioeconômicos foram correlacionados pela estimação de coeficientes lineares de Pearson, para determinar a defasagem anual otimizada. Foram estimados os coeficientes de inclinação da regressão entre a dependente doença e a independente indicador socioeconômico. RESULTADOS: Houve redução da mortalidade nos três Estados, essa ocorreu especialmente por queda de mortalidade por doenças cardiovasculares, em especial das doenças cerebrovasculares. A queda da mortalidade por doenças do aparelho circulatório foi precedida por redução da mortalidade infantil, elevação do produto interno bruto per capita e aumento na escolaridade, com forte correlação entre indicadores e taxas de mortalidade. CONCLUSÃO: A variação evolutiva dos três indicadores demonstrou correlação quase máxima com a redução da mortalidade por DApCirc. Essas relações sinalizam a importância na melhoria das condições de vida da população para reduzir a mortalidade cardiovascular.

  17. Necessidades proteicas, morbidade e mortalidade no paciente grave: fundamentos e atualidades

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    Haroldo Falcão Ramos da Cunha

    2013-03-01

    Full Text Available Evidências recentes sugerem que o balanço proteico negativo secundário à doença grave se associa ao aumento de morbidade. A perda da proteína corporal total é inevitável nesse cenário, mesmo com uma abordagem nutricional agressiva, e resulta, principalmente, do catabolismo da fibra muscular esquelética. O principal mecanismo bioquímico e metabólico envolvido nesse processo é o sistema ubiquitina-proteassoma, que, paradoxalmente, consome a adenosina trifosfatocomo fonte energética e motriz. É possível que a neutralidade do balanço proteico nessas instâncias clínicas, seja tão importante na melhora dos desfechos quanto atingir a meta calórica estimada ou medida pela calorimetria indireta. Estudos recentes apontam a utilização de concentrações mais elevadas de proteínas na terapia nutricional do paciente grave como importante para um impacto positivo na mortalidade. A proposta deste trabalho foi revisar alguns princípios da terapia nutricional relativos ao metabolismo proteico, sinalizar para as principais assertivas das diretrizes das sociedades especializadas e comentar estudos recentes, que abordam a questão em tela, sob a visão crítica da experiência clínica dos autores.

  18. Cuidado intensivo en un hospital regional: Características demográficas y mortalidad

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    Donato A Salas-Segura

    2005-07-01

    Full Text Available Objetivo: Describir las principales características de la población ingresada a la Unidad de Cuidado Intensivo, Hospital Tony Facio Castro de Limón. Materiales y métodos: Se recabó la información de todos los pacientes ingresados a la Unidad de Cuidado Intensivo del Hospital Tony Facio, durante un período de 6 meses. Los datos fueron almacenados y procesados en una base creada en SPSS 11.0. Resultados: Se estudiaron un total de 155 pacientes, 82 (53% eran hombres, 113 ingresaron del área de medicina, 34 al área quirúrgica y 8 a la ginecobstétrica. La estancia promedio fue de 5,22 días. La mayoría de los pacientes (30% ingresaron por síndrome coronario agudo. La mortalidad general fue del 15,5% (24 pacientes, y la causa principal fue shock séptico. Conclusión: Se presentan los primeros datos publicados en el país sobre las características demográficas de la población que ingresa a una unidad de cuidado intensivo

  19. Graduación de datos de mortalidad y modelos lineales generalizados

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    Francisco Montes Suay

    2002-01-01

    Full Text Available El objetivo de este trabajo es graduar los datos de mortalidad de la Comunidad Valenciana de 1998, mediante el ajuste de las funciones Gompertz-Makeham, GM(r,s, método utilizado por el CMI Bureau. Cuando las funciones GM(r,s carecen de la parte polinómica, r=0, la transformación logit de qx, probabilidad de muerte, puede ajustarse utilizando el esquema de los modelos lineales generalizados de fácil implementación en S-plus. En el trabajo que presentamos, hemos estimado los parámetros de funciones GM(0,s para s=2,3,4,5,6,7. La elección del modelo que mejor se ajusta a los datos se lleva a cabo atendiendo a criterios de bondad de ajuste y de complejidad del mismo. Se trata de buscar un equilibrio entre ambos aspectos, para lo cual utilizamos medidas y contrastes implementados en S-plus. Del análisis de los resultados se deduce que s=5 es el modelo que mejor satisface ambos criterios para la población masculina y s=6 para la femenina. De estos modelos hacemos un análisis más detallado mediante los tests no paramétricos habituales.

  20. Mortalidad del ganado vacuno ocasionada por el consumo de plantas tóxicas

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    Donald Tapia

    1999-12-01

    Full Text Available El estudio de las plantas tóxicas y sus efectos en la mortalidad del ganado vacuno es de gran importancia para el sector agropecuario de nuestro país. El presente trabajo es el inicio de un proyecto que tiene como objetivos principales clasificar taxonómicamente las plantas tóxicas y determinar por métodos experimentales la estructura química de su principio activo. Los resultados de este trabajo se pretenden editar en un manual práctico que le sirva al ganadero como material de consulta. En esta iniciativa se debe involucrar a instituciones, organismos y personas del país dedicadas a la producción de ganado vacuno como el MARENA, INTA, MAGFOR, la Asociación de ganaderos del país y los editores de la Revista Pecuaria, a fin de lograr una colaboración que permita el intercambio de experiencias.