目的：建立香附药材中总黄酮的含量测定方法。方法以芦丁为对照品，采用NaNO2-Al(NO3)3-NaOH显色，于505 nm处比色法测定香附中总黄酮的吸光度。结果芦丁在0.0052~0.0515 mg/ml范围内吸光度与浓度线性关系良好(r=0.9990)，平均回收率103.1%， RSD=1.32%。结论本方法稳定，灵敏度高，重复性好，能准确测定香附中总黄酮的含量。%Objective To establish a method for the determination of total flavonois in rhizoma cyperi. Methods Compared with rutin, contents of total flavonoids was determined in the 505 nm wavelength by colorimetry and NaNO2 in-Al (NO3)3-NaOH was adopted to develop color. Results The calibration curve was linear in the range of 0.0052~0.0515 mg/ml (r=0.9990). The average recovery was 103.1%, RSD was 1.32%. Conclusion The method is stable, highly sensitive, reproducible and thus is a accurate approach for determining flavonoids content in rhizoma cyperi.
Full Text Available During December/January 1996/97 typical summer syndrome (hyperthermia and a 30 % drop in milk yield occurred in succession in two Holstein dairy herds (n = 240 and n = 150 milking cows, respectively on the South African Highveld. These farms are situated in the midst of the prime maize and dairy farming areas of South Africa where this condition had never been diagnosed before. The individual components of the concentrate on both farms were negative for ergot alkaloids. Endophytic fungi and/or ergot infestation of teff and other grasses fed to the cows were then suspected of being involved, but neither endophytes nor ergot alkaloids could be implicated from these sources. By measuring the serum prolactin levels of groups of sheep (n = 5 fed the first farm's total mixed ration (TMR or its three individual fibre components for a period of 11 days, the source of the ergot alkaloids was identified. A statistically significant decrease in the level of this hormone occurred only in the group on maize silage (which constituted 28 % on dry matter base of the TMR. The involvement of the maize silage was further chemically confirmed by the high levels of total ergot alkaloids, predominantly ergocryptine, found by LC-MS in the silage as well as in the TMR (115-975 ppb and 65-300 ppb, respectively. The ergot alkaloid content (mainly ergocryptine of the maize silage on the second affected farm was 875 ppb. Withdrawal of contaminated silage resulted in gradual recovery of stock on both farms. Nut sedge (Cyperus esculentus and Cyperus rotundus of the family Cyperaceae has a world-wide distribution and is a common weed in annual crops, and can be parasitized by Claviceps cyperi. Careful examination of the maize silage from both farms revealed that it was heavily contaminated with nut sedge and that it contained minute sclerotia, identified as those of Claviceps cyperi, originating from the latter. Nut sedge was abundant on both farms and it is believed that
Objective:Steam distillation of Aucklandiae Radix Cyperi Rhizoma drugs on the chemical constituents of volatile oil. Method:The essential oils from woody, nutgrass galingale rhizome medicinal water steam distillation method, and gas chromatogra-phy-mass spectrometry (GC-MS) on the chemical composition analysis. Result:Extracted by steam distillation of wood-Rhizoma Cyperi drugs on volatile oil, chemical constituents were identified relative percentage content of more than 1 ‰ of the total of 96. Among them, there were 77 kinds of chemical components of volatile oil, total content of more than 80%. Conclusion:Woody, nut-grass galingale rhizome medicine extracted by steam distillation and the chemical composition of volatile oil in order to lay the founda-tion for the application.%目的：用水蒸气蒸馏法对木香-香附药对挥发油化学成分的分析。方法：用水蒸气蒸馏法提取木香-香附药的挥发油，并用气相色谱-质谱联用技术（GC-MS）对其化学成分进行分析。结果：由水蒸气蒸馏法提取的木香-香附药对的挥发油中，共鉴定出相对百分含量大于1‰的化学成分共96种。其中，共有化学成分有77种，占挥发油总含量80%以上。结论：用水蒸气蒸馏法提取木香-香附药对挥发油的化学成分为进一步应用打下基础。
陈艳红; 吴秋云; 蔡佳仲
目的 考察全国各地17批香附有效成分的含量,为香附的质量标准提供一定的依据.方法 采用蒸馏法测定不同产地香附总挥发性油含量,同时采用HPLC测定α-香附酮的含量,实验以kromasil C18(200 mm×4.6 mm 5μm)为色谱柱;流动相:甲醇-水(80:20);流速:1.0 ml/min;柱温:30℃;检验波长:250 nm.结果 α-香附酮在0.104μg～1.248μg的线性关系良好;平均回收率为99.2%,KSD为1.6%.结论 不同产地的香附中的α-香附酮含量差异较大,而总挥发油含量在0.644%～1.370%之间.
Simpson R, von Benda- Beckmann A, Tyack P, Samarra F, Miller P, Wallin J (2014) Classification of large acoustic datasets using machine learning and...10.1163/1568539X-00003195). von Benda- Beckmann , A.M., P.J. Wensveen, P.H. Kvadsheim, F.P.A. Lam, P.J.O. Miller, P.L. Tyack, M.A. Ainslie (2013
On March 11-12, 2006 the FPRI's Marvin Wachman Fund for International Education hosted 44 teachers from 16 states across the country for a weekend of discussion on teaching about India. Sessions included: (1) Why It's Important to Know about India (Ainslie T. Embree); (2) Early Indian History (Richard H. Davis); (3) Modern Indian History (Marc…
Pardo Cardona Víctor Manuel
Full Text Available Doce especies de Uredinales fueron colectados en las islas de San Andrés y Providencia durante una visita de colección efectuada en el mes de Octubre de 2002. Los hospederos fueron determinados y herborizados y a partir de ellos se elaboraron micropreparados que contenían los soros con las esporas de los hongos, los cuales fueron observados y estudiados al microscopio. Puccinia cyperi-tagetiformis Kem es nuevo registro para Colombia; se registró a Brachiaria distachya (L Stapf como nuevo hospedante de Uromyces clignyi Patouillard & Hariot y a Cyperus rotundus L como nuevo hospedante para P. cyperi-tagetiformis. Las demos especies colectados han sido registradas en el neotrópico sobre hospedantes previamente conocidos.
American Scientist (Figure 1 below); the other in UDT conference proceedings by Parvin et al.  (Figure 2). In both figures, the audiograms are in the...Beerens & M.A. Ainslie, Diver detection in Harbours, TNO report in preporation.  E.R. Gerstein, Manatees, bioacoustics and boats, American ... Scientist 90 (2), 154 (2002).  Parvin et al., S.J. Parvin, E.A Cudahy & D.M Fothergill, Guidance for diver exposure to underwater sound in the frequency
DIFFERENT BRANDS ARE REPRESENTED ON THE SMARTPHONE MARKET. IN THIS ARTICLE, THE AUTHOR REFERS TO THE STUDY OF THE DILEMMA, WHICH IS DETERMINED BY THE CUSTOMER’S CHOICE OF ONE OR ANOTHER MANUFACTURER OF SMARTPHONES. GENERAL THEORETICAL APPROACH IS BASED ON THE SCIENTIFIC WORKS OF THE SCIENTISTS: MITCHELL, W. (1914). CLARK, J.M., (1918). KATONA, G. (1980). LEIBENSTEIN, H. (1985). SIMON, H. A. (1978). GILAD, B., KAISH, S. (EDS.), (1986). AINSLIE, G. (1992). CAMERER, C. F, (1985). KIM P. CORFMAN ...
Brand, A.; Bot, E.; Ozdemir, H. [ECN Unit Wind Energy, P.O. Box 1, NL 1755 ZG Petten (Netherlands); Steinfeld, G.; Drueke, S.; Schmidt, M. [ForWind, Center for Wind Energy Research, Carl von Ossietzky Universitaet Oldenburg, D-26129 Oldenburg (Germany); Mittelmeier, N. REpower Systems SE, D-22297 Hamburg (Germany))
The ability is demonstrated to calculate wind farm wakes on the basis of ambient conditions that were calculated with an atmospheric model. Specifically, comparisons are described between predicted and observed ambient conditions, and between power predictions from three wind farm wake models and power measurements, for a single and a double wake situation. The comparisons are based on performance indicators and test criteria, with the objective to determine the percentage of predictions that fall within a given range about the observed value. The Alpha Ventus site is considered, which consists of a wind farm with the same name and the met mast FINO1. Data from the 6 REpower wind turbines and the FINO1 met mast were employed. The atmospheric model WRF predicted the ambient conditions at the location and the measurement heights of the FINO1 mast. May the predictability of the wind speed and the wind direction be reasonable if sufficiently sized tolerances are employed, it is fairly impossible to predict the ambient turbulence intensity and vertical shear. Three wind farm wake models predicted the individual turbine powers: FLaP-Jensen and FLaP-Ainslie from ForWind Oldenburg, and FarmFlow from ECN. The reliabilities of the FLaP-Ainslie and the FarmFlow wind farm wake models are of equal order, and higher than FLaP-Jensen. Any difference between the predictions from these models is most clear in the double wake situation. Here FarmFlow slightly outperforms FLaP-Ainslie.
Today's models of temporal discounting are the result of multiple interdisciplinary exchanges between psychology and economics. Although these exchanges did not result in an integrated discipline, they had important effects on all disciplines involved. The paper describes these exchanges from the 1930s onwards, focusing on two episodes in particular: an attempted synthesis by psychiatrist George Ainslie and others in the 1970s; and the attempted application of this new discounting model by a generation of economists and psychologists in the 1980s, which ultimately ended in the diversity of measurements disappointment. I draw four main conclusions. First, multiple notions of temporal discounting must be conceptually distinguished. Second, behavioral economics is not an integration or unification of psychology and economics. Third, the analysis identifies some central disciplinary markers that distinguish modeling strategies in economics and psychology. Finally, it offers a case of interdisciplinary success that does not fit the currently dominant account of interdisciplinarity as integration.
Schmidt, Jonas; Chang, Chi-Yao; Dörenkämper, Martin; Salimi, Milad; Teichmann, Tim; Stoevesandt, Bernhard
The annual energy production of an existing wind farm including thermal stratification is calculated with two different methods and compared to the average of three years of SCADA data. The first method is based on steady state computational fluid dynamics simulations and the assumption of Reynolds-similarity at hub height. The second method is a wake modelling calculation, where a new stratification transformation model was imposed on the Jensen an Ainslie wake models. The inflow states for both approaches were obtained from one year WRF simulation data of the site. Although all models underestimate the mean wind speed and wake effects, the results from the phenomenological wake transformation are compatible with high-fidelity simulation results.
Wu, Jia-Rui; Guo, Wei-Xian; Zhang, Bing; Zhang, Xiao-Meng; Yang, Bing; Sheng, Xiao-Guang
The prescriptions containing pericarpium citri reticulatae that built by Professor. Yan were collected to build a database based on traditional Chinese medicine (TCM) inheritance assist system. After analyzed by data mining, such as apriori algorithm, the frequency of single medicine, the frequency of drug combination, the association rules between drugs and core drug combinations can be get from the database. Through the analysis of 1 027 prescriptions with pericarpium citri reticulatae, these prescriptions were commonly used to treat stomach aches, cough and other syndromes. The most frequency drug combinations were "Citri Reticulatae Pericarpium-Poria", "Paeoniae Radix Rubra-Citri Reticulatae Pericarpium" and so on. The drug association rules that the confidence was 1 were "Glycyrrhizae Radix ex Rhizoma --> Citri Reticulatae Pericarpium", "Paeoniae Alba Radix-Cyperi Rhizoma --> Citri Reticulatae Pericarpium", "Poria --> Citri Reticulatae Pericarpium", and so on. The drugs in the prescriptions containing pericarpium citri reticulatae that built by Professor Yan mostly had the effects of regulating the flow of Qi and invigorate blood circulation, which reflected the clearly thought when making prescriptions.
Foxall, Gordon R
Interpretation of managerial activity in terms of neuroscience is typically concerned with extreme behaviors such as corporate fraud or reckless investment (Peterson, 2007; Wargo et al., 2010a). This paper is concerned to map out the neurophysiological and cognitive mechanisms at work across the spectrum of managerial behaviors encountered in more day-to-day contexts. It proposes that the competing neuro-behavioral decisions systems (CNBDS) hypothesis (Bickel et al., 2012b) captures well the range of managerial behaviors that can be characterized as hyper- or hypo-activity in either the limbically-based impulsive system or the frontal-cortically based executive system with the corresponding level of activity encountered in the alternative brain region. This pattern of neurophysiological responding also features in the Somatic Marker Hypothesis (Damasio, 1994) and in Reinforcement Sensitivity Theory (RST; Gray and McNaughton, 2000; McNaughton and Corr, 2004), which usefully extend the thesis, for example in the direction of personality. In discussing these theories, the paper has three purposes: to clarify the role of cognitive explanation in neuro-behavioral decision theory, to propose picoeconomics (Ainslie, 1992) as the cognitive component of competing neuro-behavioral decision systems theory and to suggest solutions to the problems of imbalanced neurophysiological activity in managerial behavior. The first is accomplished through discussion of the role of picoeconomics in neuro-behavioral decision theory; the second, by consideration of adaptive-innovative cognitive styles (Kirton, 2003) in the construction of managerial teams, a theme that can now be investigated by a dedicated research program that incorporates psychometric analysis of personality types and cognitive styles involved in managerial decision-making and the underlying neurophysiological bases of such decision-making.
Gordon Robert Foxall
Full Text Available Interpretation of managerial activity in terms of neuroscience is typically concerned with extreme behaviors such as corporate fraud or reckless investment (Wargo, Baglini & Nelson, 2010a; Peterson, 2007. This paper is concerned to map out the neurophysiological and cognitive mechanisms at work across the spectrum of managerial behaviors encountered in more day-to-day contexts. It proposes that the competing neuro-behavioral decisions systems (CNBDS hypothesis (Bickel, Mueller & Jarmolowicz, 2012 captures well the range of managerial behaviors that can be characterized as hyper- or hypo-activity in either the limbically-based impulsive system or the frontal-cortically based executive system with the corresponding level of activity encountered in the alternative brain region. This pattern of neurophysiological responding also features in the Somatic Marker Hypothesis (Damasio, 1994 and in Reinforcement Sensitivity Theory (Gray & McNaughton, 2000; McNaughton & Corr, 2004, which usefully extend the thesis, for example in the direction of personality. In discussing these theories, the paper has three purposes: to clarify the role of cognitive explanation in neuro-behavioral decision theory, to propose picoeconomics (Ainslie, 1992 as the cognitive component of competing neuro-behavioral decision systems theory and to suggest solutions to the problems of imbalanced neurophysiological activity in managerial behaviour. The first is accomplished through discussion of the role of picoeconomics in neuro-behavioral decision theory; the second, by consideration of adaptive-innovative cognitive styles (Kirton, 2003 in the construction of managerial teams, a theme that can now be investigated by a dedicated research program that incorporates psychometric analysis of personality types and cognitive styles involved in managerial decision-making and the underlying neurophysiological bases of such decision-making.
Full Text Available Timothy Peters-Strickland,1 Linda Pestreich,1 Ainslie Hatch,2 Shashank Rohatagi,1 Ross A Baker,1 John P Docherty,2 Lada Markovtsova,1 Praveen Raja,3 Peter J Weiden,4 David P Walling5 1Otsuka Pharmaceutical Development & Commercialization, Inc., 2ODH, Inc., Princeton, NJ, 3Proteus Digital Health, Inc., Redwood City, CA, 4Department of Psychiatry, University of Illinois, Chicago, IL, 5CNS Network, LLC, Long Beach, CA, USA Objective: Digital medicine system (DMS is a novel drug–device combination that objectively measures and reports medication ingestion. The DMS consists of medication embedded with an ingestible sensor (digital medicine, a wearable sensor, and software applications. This study evaluated usability of the DMS in adults with schizophrenia rated by both patients and their health care providers (HCPs during 8-week treatment with prescribed doses of digital aripiprazole.Methods: Six US sites enrolled outpatients into this Phase IIa, open-label study (NCT02219009. The study comprised a screening phase, a training phase (three weekly site visits, and a 5-week independent phase. Patients and HCPs independently rated usability of and satisfaction with the DMS.Results: Sixty-seven patients were enrolled, and 49 (73.1% patients completed the study. The mean age (SD of the patients was 46.6 years (9.7 years; the majority of them were male (74.6%, black (76.1%, and rated mildly ill on the Clinical Global Impression – Severity scale (70.1%. By the end of week 8 or early termination, 82.1% (55/67 of patients had replaced the wearable sensor independently or with minimal assistance, based on HCP rating. The patients used the wearable sensor for a mean (SD of 70.7% (24.7% and a median of 77.8% of their time in the trial. The patients contacted a call center most frequently at week 1. At the last visit, 78% (47/60 of patients were somewhat satisfied/satisfied/extremely satisfied with the DMS.Conclusion: A high proportion of patients with
Bart, M.; Ainslie, B.; Alavi, M.; Henshaw, G.; McKendry, I.; Reid, K.; Salmond, J. A.; Steyn, D.; Williams, D.
quality using data from neighbouring sensors and nearby MetroVancouver reference ozone monitors is also described. 1. D.G. Steyn, J.W. Bottenheim, R.B. Thomson, Overview of tropospheric ozone in the Lower Fraser Valley, and the Pacific '93 field study, Atmospheric Environment, Volume 31, Issue 14, July 1997, Pages 2025-2035, 10.1016/S1352-2310(97)00018-6. 2. I.G. McKendry, D.G. Steyn, J. Lundgren, R.M. Hoff, W. Strapp, K. Anlauf, F. Froude, J.B. Martin, R.M. Banta, L.D. Olivier, Elevated ozone layers and vertical down-mixing over the Lower Fraser Valley, BC, Atmospheric Environment, Volume 31, Issue 14, July 1997, Pages 2135-2146, 10.1016/S1352-2310(96)00127-6. 3. B. Ainslie, C. Reuten, D.G. Steyn, Nhu D. Le, James V. Zidek, Application of an entropy-based Bayesian optimization technique to the redesign of an existing monitoring network for single air pollutants, Journal of Environmental Management, Volume 90, Issue 8, June 2009, Pages 2715-2729, 10.1016/j.jenvman.2009.02.016. 4. J.A. Salmond, I.G. McKendry, Secondary ozone maxima in a very stable nocturnal boundary layer: observations from the Lower Fraser Valley, BC, Atmospheric Environment, Volume 36, Issue 38, December 2002, Pages 5771-5782, 10.1016/S1352-2310(02)00698-2.
施学丽; 邓家刚; 蒋筱; 范丽丽; 赵晓芳; 郭超峰
目的：应用数据挖掘技术中关联规则、聚类等方法分析乳腺增生中药专利复方配伍规律。方法：检索治疗乳腺增生中药专利复方，排除外用中药及中西药物合用的复方。对入选的中药专利复方进行术语规范化等处理，抽取信息、建立EXCEL表，应用数据分析软件包R2.15.2对数据进行关联规则分析，网络分析软件Cytoscape2.8.3聚类分析组方配伍规律。结果：195首治疗乳腺增生的中药专利复方中，发现配伍频数较高的中药为柴胡、香附、当归、夏枯草、白芍、栝蒌等；而出现频数极低且不常用的中药为八角枫叶、白鹤草等；常用的药对为柴胡-当归、莪术-三棱、乳香-没药等；强关联规则提示以柴胡、当归等核心药物组成的逍遥散为治疗乳腺增生的基本方；聚类分析结果发现连翘-土茯苓-三桠苦-功劳木-鸡血藤等“中药社团”。结论：通过对药物频数、药对、强关联规则、药物聚类的分析，可以揭示乳腺增生组方的配伍规律，为临床优化处方、提高疗效提供参考依据。%This study was aimed to reveal the medication patterns of Chinese patent medicine in the treatment of breast hyperplasia based on association rules and clustering of data mining technology. Articles on Chinese patent medicine in the treatment of breast hyperplasia were retrieved from databases. External formulas or those mixed with western drugs were excluded. Terminologies in the selected formulas were standardized. Information was extracted to build excelltables. Association rules analysis and cluster analysis were used to reveal the medication patterns of Chi-nese patent medicine in the treatment of breast hyperplasia with software R2.15.2 and Cytoscape 2.8.3. The results showed that Chinese medicinals with higher frequency in 195 formulas were Radix bupleuri, Rhizoma cyperi, Chinese Angelica, Selfheal, White Peony Root, Trichosanthes
Observation on Therapeutic Effect of Traditional Chinese Medicine and Moxibustion in Treating 128 Cases of Spleen Kidney Yang Deficiency Type Polycystic Ovary Syndrome Induced Infertility%中药加艾灸治疗脾肾阳虚型多囊卵巢综合征不孕128例疗效观察
Objective:To observe the clinical curative effect of traditional Chinese medicine combined with moxibustion therapy on pa-tients with spleen kidney yang deficiency type of polycystic ovary syndrome induced infertility.Methods:Two hundred and fifty patients who met the inclusion criteria were randomly divided into observation group (n=128)and control group (n=122).The control group a-dopted Ethinylestradiol and Cyproterone Acetate Tablets treatment,and observation group gave patients warming kidney and invigorating spleen herbs (Xianmao,Ligustrum lucidum,medlar,dodder seed,polygonatum rhizome,dangshen,wine,vinegar Rhizoma Cyperi,epime-dium,angelica,licorice root,Cornu Cervi degelatinatum)combined with Moxibustion (Guan Yuan,Qihai and Zusanli)treatment.The hormone levels (T,LH,FSH,and E2 ),follicle number,basal body temperature changes and pregnancy rates were ovserved.Results:The clinical curative rates of the observation group and the control group were respectively 42.97%and 20.49%,and the total effective rate were 87.50%and 74.59%;the normal rate of recovery of basal body temperature were 67.97%and 40.98%;pregnancy rate were re-spectively 53.13% and 26.23%;all the above indicators between the two groups showed statistically significant differences (P<0.01).T,LH and FSH levels decreased after treatment in both groups,and E2 levels were elevated,and the differences were statistically significant between the two groups (P<0.05 ).After treatment,left and right side ovarian antral follicle number of patients in the obser-vation group was lower than the control group,group comparison,the differences were statistically significant (P<0.05 ).Conclusion:Wenshen Jianpi herbs combined with moxibustion therapy on spleen kidney yang deficiency type of polycystic ovary syndrome shows bet-ter clinical curative effect than ethinylestradiol and cyproterone acetate tablets in patients with infertility,it can significantly improve hor-mone levels,basal body temperature,reduce the