WorldWideScience

Sample records for cargo compartments

  1. 46 CFR 105.25-7 - Ventilation systems for cargo tank or pumping system compartment.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Ventilation systems for cargo tank or pumping system... Requirements-When Cargo Tanks Are Installed Below Decks § 105.25-7 Ventilation systems for cargo tank or pumping system compartment. (a) Each compartment shall be provided with a mechanical exhaust system...

  2. 75 FR 6092 - Special Conditions: Model C-27J Airplane; Class E Cargo Compartment Lavatory

    Science.gov (United States)

    2010-02-08

    ... sources for a fire; and an oxygen supply system, which could intensify the growth and size of a fire... requirements for cargo- or baggage-compartment fire- or smoke-detection systems, and a standard that fire be... lavatory, and the oxygen-supply system in the lavatory, in the event of a smoke-detector alarm in the cargo...

  3. COMPARTMENTS

    DEFF Research Database (Denmark)

    Binder, Janos X; Pletscher-Frankild, Sune; Tsafou, Kalliopi

    2014-01-01

    Information on protein subcellular localization is important to understand the cellular functions of proteins. Currently, such information is manually curated from the literature, obtained from high-throughput microscopy-based screens and predicted from primary sequence. To get a comprehensive view...... of the localization of a protein, it is thus necessary to consult multiple databases and prediction tools. To address this, we present the COMPARTMENTS resource, which integrates all sources listed above as well as the results of automatic text mining. The resource is automatically kept up to date with source...... databases, and all localization evidence is mapped onto common protein identifiers and Gene Ontology terms. We further assign confidence scores to the localization evidence to facilitate comparison of different types and sources of evidence. To further improve the comparability, we assign confidence scores...

  4. 78 FR 21037 - Special Conditions: Airbus Model A330-200 Airplanes; Bulk Cargo Lower Deck Crew Rest Compartments

    Science.gov (United States)

    2013-04-09

    ... of special tools. The lock must not prevent opening from the inside of the compartment at any time. 2... hatch or door can be opened when a person, the weight of a ninety-fifth percentile male, is standing on... male) from the crew rest compartment to the passenger cabin floor. The evacuation must be demonstrated...

  5. Compartment syndrome

    Science.gov (United States)

    ... term (chronic) compartment syndrome can be caused by repetitive activities, such as running. The pressure in a compartment ... or loosened to relieve the pressure Stopping the repetitive activity or exercise, or changing the way it's done ...

  6. Compartment syndromes

    Science.gov (United States)

    Mubarak, S. J.; Pedowitz, R. A.; Hargens, A. R.

    1989-01-01

    The compartment syndrome is defined as a condition in which high pressure within a closed fascial space (muscle compartment) reduces capillary blood perfusion below the level necessary for tissue viability'. This condition occurs in acute and chronic (exertional) forms, and may be secondary to a variety of causes. The end-result of an extended period of elevated intramuscular pressure may be the development of irreversible tissue injury and Volkmann's contracture. The goal of treatment of the compartment syndrome is the reduction of intracompartmental pressure thus facilitating reperfusion of ischaemic tissue and this goal may be achieved by decompressive fasciotomy. Controversy exists regarding the critical pressure-time thresholds for surgical decompression and the optimal diagnostic methods of measuring intracompartmental pressures. This paper will update and review some current knowledge regarding the pathophysiology, aetiology, diagnosis, and treatment of the acute compartment syndrome.

  7. The Cargo

    DEFF Research Database (Denmark)

    Birch, Thomas; Charlton, Michael F.; Biggs, Lynn

    2014-01-01

    The Gresham ship was carrying a substantial cargo of different metals when she sank, representing a considerable financial loss. Reports record that some of that material recovered in 1846 included 2700 tin ingots, lead pigs and iron bars (British Archaeological Association, 1847, 361......). The excavations in 2003–4 found a further three stamped lead ingots, five tin ingots and 42 iron bars from the hull area of the ship. The size of the original cargo remains unknown, though the estimated capacity of the ship, perhaps some 150 tons, provides an indication. In this chapter, the assemblage of lead...... and tin ingots and the bar iron will be described, the production processes established and the innovative analytical evidence for the provenance of the metals discussed. The research presented here suggests that lead ingots were from Derbyshire, the tin from Cornwall, but the bar iron seems...

  8. Wisconsin Air Cargo Study

    Science.gov (United States)

    2011-04-01

    Air cargo is a key economic lifeline for the communities that have airports. Manufacturers, businesses, hospitals and : other community cornerstone employers depend on air cargo to successfully operate. While there is no doubt that air : cargo repres...

  9. 76 FR 4847 - Hazardous Materials: Safety Requirements for External Product Piping on Cargo Tanks Transporting...

    Science.gov (United States)

    2011-01-27

    ... cargo compartment valves are closed, the system introduces compressed air from an auxiliary tank through... in unprotected external product piping on DOT specification cargo tank motor vehicles. If adopted as... only) hazardous materials in external product piping of a DOT specification cargo tank motor vehicle...

  10. Study of biological compartments

    International Nuclear Information System (INIS)

    Rocha, A.F.G. da

    1976-01-01

    The several types of biological compartments are studied such as monocompartmental system, one-compartment balanced system irreversible fluxes, two closed compartment system, three compartment systems, catenary systems and mammilary systems [pt

  11. 46 CFR 154.534 - Cargo pumps and cargo compressors.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo pumps and cargo compressors. 154.534 Section 154.534 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES... Equipment Cargo and Process Piping Systems § 154.534 Cargo pumps and cargo compressors. Cargo pumps and...

  12. Cargo recognition and cargo-mediated regulation of unconventional myosins.

    Science.gov (United States)

    Lu, Qing; Li, Jianchao; Zhang, Mingjie

    2014-10-21

    Organized motions are hallmarks of living organisms. Such motions range from collective cell movements during development and muscle contractions at the macroscopic scale all the way down to cellular cargo (e.g., various biomolecules and organelles) transportation and mechanoforce sensing at more microscopic scales. Energy required for these biological motions is almost invariably provided by cellular chemical fuels in the form of nucleotide triphosphate. Biological systems have designed a group of nanoscale engines, known as molecular motors, to convert cellular chemical fuels into mechanical energy. Molecular motors come in various forms including cytoskeleton motors (myosin, kinesin, and dynein), nucleic-acid-based motors, cellular membrane-based rotary motors, and so on. The main focus of this Account is one subfamily of actin filament-based motors called unconventional myosins (other than muscle myosin II, the remaining myosins are collectively referred to as unconventional myosins). In general, myosins can use ATP to fuel two types of mechanomotions: dynamic tethering actin filaments with various cellular compartments or structures and actin filament-based intracellular transport. In contrast to rich knowledge accumulated over many decades on ATP hydrolyzing motor heads and their interactions with actin filaments, how various myosins recognize their specific cargoes and whether and how cargoes can in return regulate functions of motors are less understood. Nonetheless, a series of biochemical and structural investigations in the past few years, including works from our own laboratory, begin to shed lights on these latter questions. Some myosins (e.g., myosin-VI) can function both as cellular transporters and as mechanical tethers. To function as a processive transporter, myosins need to form dimers or multimers. To be a mechanical tether, a monomeric myosin is sufficient. It has been shown for myosin-VI that its cellular cargo proteins can play critical roles

  13. Air Cargo Marketing Development

    Science.gov (United States)

    Kersey, J. W.

    1972-01-01

    The factors involved in developing a market for air cargo services are discussed. A comparison is made between the passenger traffic problems and those of cargo traffic. Emphasis is placed on distribution analyses which isolates total distribution cost, including logistical costs such as transportation, inventory, materials handling, packaging, and processing. Specific examples of methods for reducing air cargo costs are presented.

  14. A role for cargo in Arf-dependent adaptor recruitment.

    Science.gov (United States)

    Caster, Amanda H; Sztul, Elizabeth; Kahn, Richard A

    2013-05-24

    Membrane traffic requires the specific concentration of protein cargos and exclusion of other proteins into nascent carriers. Critical components of this selectivity are the protein adaptors that bind to short, linear motifs in the cytoplasmic tails of transmembrane protein cargos and sequester them into nascent carriers. The recruitment of the adaptors is mediated by activated Arf GTPases, and the Arf-adaptor complexes mark sites of carrier formation. However, the nature of the signal(s) that initiates carrier biogenesis remains unknown. We examined the specificity and initial sites of recruitment of Arf-dependent adaptors (AP-1 and GGAs) in response to the Golgi or endosomal localization of specific cargo proteins (furin, mannose-6-phosphate receptor (M6PR), and M6PR lacking a C-terminal domain M6PRΔC). We find that cargo promotes the recruitment of specific adaptors, suggesting that it is part of an upstream signaling event. Cargos do not promote adaptor recruitment to all compartments in which they reside, and thus additional factors regulate the cargo's ability to promote Arf activation and adaptor recruitment. We document that within a given compartment different cargos recruit different adaptors, suggesting that there is little or no free, activated Arf at the membrane and that Arf activation is spatially and temporally coupled to the cargo and the adaptor. Using temperature block, brefeldin A, and recovery from each, we found that the cytoplasmic tail of M6PR causes the recruitment of AP-1 and GGAs to recycling endosomes and not at the Golgi, as predicted by steady state staining profiles. These results are discussed with respect to the generation of novel models for cargo-dependent regulation of membrane traffic.

  15. A Role for Cargo in Arf-dependent Adaptor Recruitment*

    Science.gov (United States)

    Caster, Amanda H.; Sztul, Elizabeth; Kahn, Richard A.

    2013-01-01

    Membrane traffic requires the specific concentration of protein cargos and exclusion of other proteins into nascent carriers. Critical components of this selectivity are the protein adaptors that bind to short, linear motifs in the cytoplasmic tails of transmembrane protein cargos and sequester them into nascent carriers. The recruitment of the adaptors is mediated by activated Arf GTPases, and the Arf-adaptor complexes mark sites of carrier formation. However, the nature of the signal(s) that initiates carrier biogenesis remains unknown. We examined the specificity and initial sites of recruitment of Arf-dependent adaptors (AP-1 and GGAs) in response to the Golgi or endosomal localization of specific cargo proteins (furin, mannose-6-phosphate receptor (M6PR), and M6PR lacking a C-terminal domain M6PRΔC). We find that cargo promotes the recruitment of specific adaptors, suggesting that it is part of an upstream signaling event. Cargos do not promote adaptor recruitment to all compartments in which they reside, and thus additional factors regulate the cargo's ability to promote Arf activation and adaptor recruitment. We document that within a given compartment different cargos recruit different adaptors, suggesting that there is little or no free, activated Arf at the membrane and that Arf activation is spatially and temporally coupled to the cargo and the adaptor. Using temperature block, brefeldin A, and recovery from each, we found that the cytoplasmic tail of M6PR causes the recruitment of AP-1 and GGAs to recycling endosomes and not at the Golgi, as predicted by steady state staining profiles. These results are discussed with respect to the generation of novel models for cargo-dependent regulation of membrane traffic. PMID:23572528

  16. Multipurpose Cargo Transfer Bag

    Science.gov (United States)

    Broyan, James; Baccus, Shelley

    2014-01-01

    The Logistics Reduction (LR) project within the Advanced Exploration Systems (AES) program is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) have been designed such that they can serve the same purpose as a Cargo Transfer Bag, the suitcase-shaped common logistics carrying bag for Shuttle and the International Space Station. After use as a cargo carrier, a regular CTB becomes trash, whereas the MCTB can be unzipped, unsnapped, and unfolded to be reused. Reuse ideas that have been investigated include partitions, crew quarters, solar radiation storm shelters, acoustic blankets, and forward osmosis water processing.

  17. Air Cargo Security

    Science.gov (United States)

    2007-07-30

    security identification display areas ( SIDAs ). This effectively elevates the required security measures for these cargo handling areas and requires...monitoring. Additional technologies, such as computer algorithms for highlighting potential threat objects, may also be considered to aid human observers

  18. ACUTE COMPARTMENT SYNDROME

    African Journals Online (AJOL)

    muscle destruction, muscle fibrosis, contractures and permanent disability and at worst case scenario of amputation (3,4). As reported by Frink et al (3) on their study on acute compartment syndrome it can occur even when there is no fracture. Also general surgeons have reported acute compartment syndrome.

  19. Cargo Data Management Demonstration System

    Science.gov (United States)

    1974-02-01

    Delays in receipt and creation of cargo documents are a problem in international trade. The work described demonstrates some of the advantages and capabilities of a computer-based cargo data management system. A demonstration system for data manageme...

  20. DNA Virus Replication Compartments

    Science.gov (United States)

    Schmid, Melanie; Speiseder, Thomas; Dobner, Thomas

    2014-01-01

    Viruses employ a variety of strategies to usurp and control cellular activities through the orchestrated recruitment of macromolecules to specific cytoplasmic or nuclear compartments. Formation of such specialized virus-induced cellular microenvironments, which have been termed viroplasms, virus factories, or virus replication centers, complexes, or compartments, depends on molecular interactions between viral and cellular factors that participate in viral genome expression and replication and are in some cases associated with sites of virion assembly. These virus-induced compartments function not only to recruit and concentrate factors required for essential steps of the viral replication cycle but also to control the cellular mechanisms of antiviral defense. In this review, we summarize characteristic features of viral replication compartments from different virus families and discuss similarities in the viral and cellular activities that are associated with their assembly and the functions they facilitate for viral replication. PMID:24257611

  1. Abdominal Compartment Syndrome

    Directory of Open Access Journals (Sweden)

    Pınar Zeyneloğlu

    2015-04-01

    Full Text Available Intraabdominal hypertension and Abdominal compartment syndrome are causes of morbidity and mortality in critical care patients. Timely diagnosis and treatment may improve organ functions. Intra-abdominal pressure monitoring is vital during evaluation of the patients and in the management algorithms. The incidence, definition and risk factors, clinical presentation, diagnosis and management of intraabdominal hypertension and Abdominal compartment syndrome were reviewed here.

  2. Large Cargo Containers

    Science.gov (United States)

    1974-09-20

    FS ( ’ ’ \\ F4 f 1 NOTE: Fx , F2, F3, F^ - 15 Long Tons Minimum for ANSI MH 5.1.1. Figure 6, Externally...the various modes. The containerized cargo may be palletized or in unit loads. Existing facili- ties permit the makeup and simulation of most...on ramp. Loading dock on railcar truck/tractor Rail train makeup Switch engine Railway Loading dock to Forklift, MHE Ramp truck Loading dock to

  3. Spontaneous Thigh Compartment Syndrome

    Directory of Open Access Journals (Sweden)

    Khan, Sameer K

    2011-02-01

    Full Text Available A young man presented with a painful and swollen thigh, without any history of trauma, illness, coagulopathic medication or recent exertional exercise. Preliminary imaging delineated a haematoma in the anterior thigh, without any fractures or muscle trauma. Emergent fasciotomies were performed. No pathology could be identified intra-operatively, or on follow-up imaging. A review of thigh compartment syndromes described in literature is presented in a table. Emergency physicians and traumatologists should be cognisant of spontaneous atraumatic presentations of thigh compartment syndrome, to ensure prompt referral and definitive management of this limb-threatening condition. [West J Emerg Med. 2011;12(1:134-138].

  4. Chronic Exertional Compartment Syndrome

    Science.gov (United States)

    ... it's more common in athletes who participate in activities that involve repetitive impact, such as running. Chronic exertional compartment syndrome ... and female athletes under 30. Type of exercise. Repetitive impact activity — such as running or fast walking — increases your ...

  5. Cargo-cult training

    Science.gov (United States)

    Magueijo, João

    2009-12-01

    Richard Feynman, in one of his famous rants, evoked as a metaphor what he called "cargo-cult science". During the Second World War, the indigenous people of the South Pacific became accustomed to US Air Force planes landing on their islands, invariably bringing a profusion of desirable goods and tasty foods. When the war ended, they were distressed by the discontinuation of this popular service. So, they decided to take action. They cleared elongated patches of land to make them look like runways. They lit wood fires where they had seen electric floodlights guiding in the planes. They built a wooden shack and made a man sit inside with two halves of a coconut on each ear and bamboo bars sticking out like antennas: he was the "air controller". And they waited for the planes to return.

  6. Compartment syndrome without pain!

    LENUS (Irish Health Repository)

    O'Sullivan, M J

    2012-02-03

    We report the case of a young male patient who underwent intra-medullary nailing for a closed, displaced mid-shaft fracture of tibia and fibula. He was commenced on patient controlled analgesia post-operatively. A diagnosis of compartment syndrome in the patient\\'s leg was delayed because he did not exhibit a pain response. This ultimately resulted in a below-knee amputation of the patient\\'s leg. We caution against the use of patient controlled analgesia in any traumatised limb distal to the hip or the shoulder.

  7. 29 CFR 1918.94 - Ventilation and atmospheric conditions (See also § 1918.2, definitions of Hazardous cargo...

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Ventilation and atmospheric conditions (See also § 1918.2.... § 1918.94 Ventilation and atmospheric conditions (See also § 1918.2, definitions of Hazardous cargo... that the compartment's atmosphere is within allowable limits. (See paragraph (b)(3) of this section...

  8. 36 CFR 1192.127 - Sleeping compartments.

    Science.gov (United States)

    2010-07-01

    ... compartment. (c) Controls and operating mechanisms (e.g., heating and air conditioning controls, lighting... Intercity Rail Cars and Systems § 1192.127 Sleeping compartments. (a) Sleeping compartments required to be...

  9. 46 CFR 153.908 - Cargo viscosity and melting point information; measuring cargo temperature during discharge...

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo viscosity and melting point information; measuring... Cargo viscosity and melting point information; measuring cargo temperature during discharge: Categories... lading, a written statement of the following: (1) For Category A or B NLS, the cargo's viscosity at 20 °C...

  10. 46 CFR 153.907 - Cargo information.

    Science.gov (United States)

    2010-10-01

    ... Information § 153.907 Cargo information. (a) The master shall ensure that the following information for each... process for the vessel. (b) The master shall make sure that the following information for cargoes other... of these two tables. (2) The name of the cargo prescribed in the letter authorizing carriage of the...

  11. Dual-Compartment Inflatable Suitlock

    Science.gov (United States)

    Kennedy, Kriss J.; Guirgis, Peggy L.; Boyle, Robert M.

    2013-01-01

    There is a need for an improvement over current NASA Extravehicular Activity (EVA) technology. The technology must allow the capacity for quicker, more efficient egress/ingress, allow for shirtsleeve suit maintenance, be compact in transport, and be applicable to environments ranging from planetary surface (partial-g) to orbital or deep space zero-g environments. The technology must also be resistant to dust and other foreign contaminants that may be present on or around a planetary surface. The technology should be portable, and be capable of docking with a variety of habitats, ports, stations, vehicles, and other pressurized modules. The Dual-Compartment Inflatable Suitlock (DCIS) consists of three hard inline bulkheads, separating two cylindrical membrane-walled compartments. The Inner Bulkhead can be fitted with a variety of hatch types, docking flanges, and mating hardware, such as the Common Berthing Mechanism (CBM), for the purpose of mating with vehicles, habitats, and other pressurized modules. The Inner Bulkhead and Center Bulkhead function as the end walls of the Inner Compartment, which during operations, would stay pressurized, either matching the pressure of the habitat or acting as a lower-pressure transitional volume. The Inner Compartment contains donning/doffing fixtures and inner suit-port hatches. The Center Bulkhead has two integrated suit-ports along with a maintenance hatch. The Center Bulkhead and Outer Bulkhead function as the end walls of the Outer Compartment, which stays at vacuum during normal operations. This allows the crewmember to quickly don a suit, and egress the suitlock without waiting for the Outer Compartment to depressurize. The Outer Compartment can be pressurized infrequently for both nominal and off-nominal suit maintenance tasks, allowing shirtsleeve inspections and maintenance/repair of the environmental suits. The Outer Bulkhead has a pressure-assisted hatch door that stays open and stowed during EVA operations, but can

  12. Characterizing Density and Complexity of Imported Cargos

    Energy Technology Data Exchange (ETDEWEB)

    Birrer, Nathaniel [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Divin, Charles [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Glenn, Steven [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Martz, Harry [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-08-01

    X-ray inspection systems are used to detect radiological and nuclear threats in imported cargo. In order to better understand performance of these systems, system imaging capabilities and the characteristics of imported cargo need to be determined. This project involved calculation of the modulation transfer function as a metric of system imaging performance and a study of the density and inhomogeneity of imported cargos, which have been shown to correlate with human analysts, threat detection performance.

  13. Understanding X-ray cargo imaging

    International Nuclear Information System (INIS)

    Chen Gongyin

    2005-01-01

    Cargo imaging is the field of imaging large objects, usually cargo containers, trains, trucks or boats. Transmission imaging with photons, especially X-rays of up to 9 MV is the dominant current technique, providing compelling details of the contents of objects this large. This paper discusses the physics aspects of a good X-ray cargo imaging system. The basic performance requirements, such as penetration, contrast and resolution and the components of a cargo imaging system are introduced. The imaging process is divided in this paper into three stages: forming information (probing the object), recording information and presenting information (image display). Their impact on performance is analyzed

  14. 46 CFR 64.89 - Cargo pump unit.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Cargo pump unit. 64.89 Section 64.89 Shipping COAST... HANDLING SYSTEMS Cargo Handling System § 64.89 Cargo pump unit. (a) A cargo pump unit that fills or...) The cargo pump power unit must be— (1) Diesel; (2) Hydraulic; (3) Pneumatic; or (4) Electric. (c) The...

  15. 46 CFR 154.554 - Cargo hose: Bursting pressure.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo hose: Bursting pressure. 154.554 Section 154.554... Hose § 154.554 Cargo hose: Bursting pressure. Cargo hose that may be exposed to the pressure in the cargo tank, the cargo pump discharge, or the vapor compressor discharge must have a bursting pressure of...

  16. 33 CFR 105.265 - Security measures for handling cargo.

    Science.gov (United States)

    2010-07-01

    ... SECURITY MARITIME SECURITY MARITIME SECURITY: FACILITIES Facility Security Requirements § 105.265 Security... to do so, routinely check cargo, cargo transport units, and cargo storage areas within the facility..., containers, or other cargo transport units entering the facility match the delivery note or equivalent cargo...

  17. 46 CFR 154.235 - Cargo tank location.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo tank location. 154.235 Section 154.235 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS... Survival Capability and Cargo Tank Location § 154.235 Cargo tank location. (a) For type IG hulls, cargo...

  18. 19 CFR 149.4 - Bulk and break bulk cargo.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Bulk and break bulk cargo. 149.4 Section 149.4... TREASURY (CONTINUED) IMPORTER SECURITY FILING § 149.4 Bulk and break bulk cargo. (a) Bulk cargo exempted.... (b) Break bulk cargo exempted from time requirement. For break bulk cargo that is exempt from the...

  19. Myosin-Powered Membrane Compartment Drives Cytoplasmic Streaming, Cell Expansion and Plant Development.

    Science.gov (United States)

    Peremyslov, Valera V; Cole, Rex A; Fowler, John E; Dolja, Valerian V

    2015-01-01

    Using genetic approaches, particle image velocimetry and an inert tracer of cytoplasmic streaming, we have made a mechanistic connection between the motor proteins (myosins XI), cargo transported by these motors (distinct endomembrane compartment defined by membrane-anchored MyoB receptors) and the process of cytoplasmic streaming in plant cells. It is shown that the MyoB compartment in Nicotiana benthamiana is highly dynamic moving with the mean velocity of ~3 μm/sec. In contrast, Golgi, mitochondria, peroxisomes, carrier vesicles and a cytosol flow tracer share distinct velocity profile with mean velocities of 0.6-1.5 μm/sec. Dominant negative inhibition of the myosins XI or MyoB receptors using overexpression of the N. benthamiana myosin cargo-binding domain or MyoB myosin-binding domain, respectively, resulted in velocity reduction for not only the MyoB compartment, but also each of the tested organelles, vesicles and cytoplasmic streaming. Furthermore, the extents of this reduction were similar for each of these compartments suggesting that MyoB compartment plays primary role in cytosol dynamics. Using gene knockout analysis in Arabidopsis thaliana, it is demonstrated that inactivation of MyoB1-4 results in reduced velocity of mitochondria implying slower cytoplasmic streaming. It is also shown that myosins XI and MyoB receptors genetically interact to contribute to cell expansion, plant growth, morphogenesis and proper onset of flowering. These results support a model according to which myosin-dependent, MyoB receptor-mediated transport of a specialized membrane compartment that is conserved in all land plants drives cytoplasmic streaming that carries organelles and vesicles and facilitates cell growth and plant development.

  20. Myosin-Powered Membrane Compartment Drives Cytoplasmic Streaming, Cell Expansion and Plant Development.

    Directory of Open Access Journals (Sweden)

    Valera V Peremyslov

    Full Text Available Using genetic approaches, particle image velocimetry and an inert tracer of cytoplasmic streaming, we have made a mechanistic connection between the motor proteins (myosins XI, cargo transported by these motors (distinct endomembrane compartment defined by membrane-anchored MyoB receptors and the process of cytoplasmic streaming in plant cells. It is shown that the MyoB compartment in Nicotiana benthamiana is highly dynamic moving with the mean velocity of ~3 μm/sec. In contrast, Golgi, mitochondria, peroxisomes, carrier vesicles and a cytosol flow tracer share distinct velocity profile with mean velocities of 0.6-1.5 μm/sec. Dominant negative inhibition of the myosins XI or MyoB receptors using overexpression of the N. benthamiana myosin cargo-binding domain or MyoB myosin-binding domain, respectively, resulted in velocity reduction for not only the MyoB compartment, but also each of the tested organelles, vesicles and cytoplasmic streaming. Furthermore, the extents of this reduction were similar for each of these compartments suggesting that MyoB compartment plays primary role in cytosol dynamics. Using gene knockout analysis in Arabidopsis thaliana, it is demonstrated that inactivation of MyoB1-4 results in reduced velocity of mitochondria implying slower cytoplasmic streaming. It is also shown that myosins XI and MyoB receptors genetically interact to contribute to cell expansion, plant growth, morphogenesis and proper onset of flowering. These results support a model according to which myosin-dependent, MyoB receptor-mediated transport of a specialized membrane compartment that is conserved in all land plants drives cytoplasmic streaming that carries organelles and vesicles and facilitates cell growth and plant development.

  1. Imaging of iliopsoas compartment disease

    International Nuclear Information System (INIS)

    Rocher, L.; Saint Maurice, J.P.; Le Quen, O.; Bazille, A.; Miquel, A.; Frouge, C.; Blery, M.

    1997-01-01

    Infection, neoplastic involvement, and hemorrhage, are the most frequent pathologies that involve the ilio-psoas compartment. The extension from contiguous pathological structures and particularly digestive and urological organs, are often the origin of abscess formation or malignant tumours. The radiological findings including ultrasonography, CT, and magnetic resonance imaging, show a low specificity, which improves if the clinical history is known. The final diagnosis is confirmed by puncture or biopsy. (author)

  2. Numerical treatment of compartment models

    International Nuclear Information System (INIS)

    Einarsson, B.

    1984-11-01

    This report describes and interactive program RADIO (Radioactive Decay Information Online) for studying the radioactive decay process, with applications to many ecological problems, but not necessarily involving radioactive processes. Starting with the compartment coefficients and initial values of the various compartments the problem is solved as a system of linear ordinary differential equations. The method of solution is the direct use of matrix exponentials or the backward differences method. A program INVERS is also available for the solution of the inverse problem, that is parameter estimation in a system of linear ordinary differential equations when the solution is available pointwise. The output can be printed on a line printer either from a result file or from the plot file, which of course also can be used to produce graphic output. The plot file is processed by the plotting program VISION or by the auxiliary printing program RADAR. Another file can be used for a later restart from the point of time where the previous computation was aborted or from an arbitrary point of time if the relevant starting information is available. This is useful in order to avoid the manual input of a compartment matrix if it is similar to one used before. When the program RADIO is run the user answers to the question asked by the program. The programs are written in Fortran 77 for the Digital Equipment VAX 11 with graphical presentation on a Tektronix 4010, and are available from the author. (Author)

  3. Control system maintains compartment at constant temperature

    Science.gov (United States)

    Lindberg, J. G.

    1966-01-01

    Gas-filled permeable insulating material maintains an enclosed compartment at a uniform temperature. The material is interposed between the two walls of a double-walled enclosure surrounding the compartment.

  4. 46 CFR 154.1810 - Cargo manual.

    Science.gov (United States)

    2010-10-01

    ... with inert gas and air. (13) A description of hull and cargo tank temperature monitoring systems. (14... vaporization system. (v) Gas main system. (vi) Cargo tank or compressor relief system and blocked liquid or gas relief system. (vii) Inerting system. (viii) Boil-off gas compressor or reliquefaction system. (ix) Gas...

  5. Unmanned Cargo Aircraft : From Anywhere to Everywhere

    NARCIS (Netherlands)

    Heerkens, Hans

    2017-01-01

    While unmanned aircraft have been in use for decades, their suitability for transporting cargo is only now slowly being recognised. The first prototypes of unmanned cargo aircraft (UCA) are currently being tested. There are two categories of UCA: short-distance aircraft for delivering packages and

  6. 78 FR 68784 - Cargo Securing Manuals

    Science.gov (United States)

    2013-11-15

    ... mitigate the consequences of vessel cargo loss. This rulemaking promotes the Coast Guard's maritime safety... Transportation's Maritime Administration MSC Maritime Safety Committee MISLE Marine Information for Safety and... History Improperly secured maritime cargo threatens the safety of life, property, and the environment...

  7. 76 FR 51847 - Air Cargo Screening

    Science.gov (United States)

    2011-08-18

    ... Chain Management Professionals, Express Delivery and Logistics Association, International Air Transport... diverse needs of the air cargo supply chain. TSA Response: The 9/11 Act required the Secretary of Homeland... allows industry participants to conduct screening at stages earlier within the cargo supply chain and off...

  8. 46 CFR 153.285 - Valving for cargo pump manifolds.

    Science.gov (United States)

    2010-10-01

    ... SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Piping Systems and Cargo Handling Equipment § 153.285 Valving for cargo pump manifolds. (a) When cargo...

  9. 46 CFR 153.282 - Cargo filling lines.

    Science.gov (United States)

    2010-10-01

    ... BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Piping Systems and Cargo Handling Equipment § 153.282 Cargo filling lines. The discharge point of a cargo tank...

  10. 46 CFR 153.316 - Special cargo pumproom ventilation rate.

    Science.gov (United States)

    2010-10-01

    ... CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Handling Space Ventilation § 153.316 Special cargo pumproom ventilation rate. When Table 1...

  11. Cargo-mix optimization in Liner Shipping

    DEFF Research Database (Denmark)

    Christensen, Jonas Mark; Pacino, Dario; Fonseca, Joao Filipe Paiva

    ’ utilization.The more containers a vessel carries the smaller is the resulting CO2 emissions per transported tonof cargo. This is what can be seen as a win-win situation. Better vessel utilization will result bothin cleaner transport and in better revenue margins for the shippers. Focus on vessel intake...... maximization is old news for liner shippers. Container vessels are deliveredwith a nominal capacity that ship owners know is only theoretical. Unless the cargo weightdistribution is perfect, the nominal intake cannot be reached. Stowage coordinators fight this battleeveryday. They are the planners of the cargo...... and have to find a load configuration (stowage plan)that both suits the current cargo to be loaded but also guarantees that the vessel can be utilizedto its maximum in future ports. The size of nowadays vessels is, however, making this work harderand harder (Pacino et al. (2011)). Moreover, the cargo...

  12. Safety of Cargo Aircraft Handling Procedure

    Directory of Open Access Journals (Sweden)

    Daniel Hlavatý

    2017-07-01

    Full Text Available The aim of this paper is to get acquainted with the ways how to improve the safety management system during cargo aircraft handling. The first chapter is dedicated to general information about air cargo transportation. This includes the history or types of cargo aircraft handling, but also the means of handling. The second part is focused on detailed description of cargo aircraft handling, including a description of activities that are performed before and after handling. The following part of this paper covers a theoretical interpretation of safety, safety indicators and legislative provisions related to the safety of cargo aircraft handling. The fourth part of this paper analyzes the fault trees of events which might occur during handling. The factors found by this analysis are compared with safety reports of FedEx. Based on the comparison, there is a proposal on how to improve the safety management in this transportation company.

  13. volkmann's ischaemic contracture following acute compartment

    African Journals Online (AJOL)

    2006-06-02

    Jun 2, 2006 ... Compartment syndrome most commonly involves the forearm and lower leg. Acute compartment syndrome refers to acute ischaemia of the muscles and nerves within a compartment due to elevated intra-compartmental pressure. In 1881 Volkmann stated that the paralytic contractures that could develop in ...

  14. 24 CFR 3280.111 - Toilet compartments.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Toilet compartments. 3280.111... Toilet compartments. Each toilet compartment shall be a minimum of 30 inches in width, except, when the toilet is located adjacent to the short dimension of the tub, the distance from the tub to the center...

  15. Characterizing the composition of molecular motors on moving axonal cargo using "cargo mapping" analysis.

    Science.gov (United States)

    Neumann, Sylvia; Campbell, George E; Szpankowski, Lukasz; Goldstein, Lawrence S B; Encalada, Sandra E

    2014-10-30

    Understanding the mechanisms by which molecular motors coordinate their activities to transport vesicular cargoes within neurons requires the quantitative analysis of motor/cargo associations at the single vesicle level. The goal of this protocol is to use quantitative fluorescence microscopy to correlate ("map") the position and directionality of movement of live cargo to the composition and relative amounts of motors associated with the same cargo. "Cargo mapping" consists of live imaging of fluorescently labeled cargoes moving in axons cultured on microfluidic devices, followed by chemical fixation during recording of live movement, and subsequent immunofluorescence (IF) staining of the exact same axonal regions with antibodies against motors. Colocalization between cargoes and their associated motors is assessed by assigning sub-pixel position coordinates to motor and cargo channels, by fitting Gaussian functions to the diffraction-limited point spread functions representing individual fluorescent point sources. Fixed cargo and motor images are subsequently superimposed to plots of cargo movement, to "map" them to their tracked trajectories. The strength of this protocol is the combination of live and IF data to record both the transport of vesicular cargoes in live cells and to determine the motors associated to these exact same vesicles. This technique overcomes previous challenges that use biochemical methods to determine the average motor composition of purified heterogeneous bulk vesicle populations, as these methods do not reveal compositions on single moving cargoes. Furthermore, this protocol can be adapted for the analysis of other transport and/or trafficking pathways in other cell types to correlate the movement of individual intracellular structures with their protein composition. Limitations of this protocol are the relatively low throughput due to low transfection efficiencies of cultured primary neurons and a limited field of view available for

  16. Design of heavy lift cargo aircraft

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the bird of the skies of the future. The heavy lift cargo aircraft which is currently being developed by me has twice the payload capacity of an Antonov...

  17. Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval

    Science.gov (United States)

    Mori, Yasunori; Takamori, Shigeo

    2018-01-01

    Efficient retrieval of the synaptic vesicle (SV) membrane from the presynaptic plasma membrane, a process called endocytosis, is crucial for the fidelity of neurotransmission, particularly during sustained neural activity. Although multiple modes of endocytosis have been identified, it is clear that the efficient retrieval of the major SV cargos into newly formed SVs during any of these modes is fundamental for synaptic transmission. It is currently believed that SVs are eventually reformed via a clathrin-dependent pathway. Various adaptor proteins recognize SV cargos and link them to clathrin, ensuring the efficient retrieval of the cargos into newly formed SVs. Here, we summarize our current knowledge of the molecular signatures within individual SV cargos that underlie efficient retrieval into SV membranes, as well as discuss possible contributions of the mechanisms under physiological conditions. PMID:29379416

  18. Military Airlift: The Joint Cargo Aircraft Program

    National Research Council Canada - National Science Library

    Knight, William

    2007-01-01

    Joint Cargo Aircraft (JCA) is a joint acquisition program between the Army and the Air Force designed to procure a commercial off-the-shelf aircraft, capable of meeting Army requirements for "direct support" to maneuver units...

  19. Military Airlift: The Joint Cargo Aircraft Program

    National Research Council Canada - National Science Library

    Hess, Allan

    2008-01-01

    Joint Cargo Aircraft (JCA) is a joint acquisition program between the Army and Air Force intended to procure a commercial off-the-shelf aircraft capable of meeting Army and Air Force requirements for intra-theater airlift...

  20. 76 FR 53080 - Air Cargo Screening; Correction

    Science.gov (United States)

    2011-08-25

    ...: Transportation Security Administration, DHS. ACTION: Final rule; request for comments; correction. SUMMARY: The Transportation Security Administration (TSA) is correcting the Air Cargo Screening final rule published in the... DEPARTMENT OF HOMELAND SECURITY Transportation Security Administration 49 CFR Parts 1515, 1520...

  1. System for inspection of stacked cargo containers

    Science.gov (United States)

    Derenzo, Stephen [Pinole, CA

    2011-08-16

    The present invention relates to a system for inspection of stacked cargo containers. One embodiment of the invention generally comprises a plurality of stacked cargo containers arranged in rows or tiers, each container having a top, a bottom a first side, a second side, a front end, and a back end; a plurality of spacers arranged in rows or tiers; one or more mobile inspection devices for inspecting the cargo containers, wherein the one or more inspection devices are removeably disposed within the spacers, the inspection means configured to move through the spacers to detect radiation within the containers. The invented system can also be configured to inspect the cargo containers for a variety of other potentially hazardous materials including but not limited to explosive and chemical threats.

  2. Linking molecular motors to membrane cargo.

    Science.gov (United States)

    Akhmanova, Anna; Hammer, John A

    2010-08-01

    Three types of motors, myosins, kinesins, and cytoplasmic dynein, cooperate to transport intracellular membrane organelles. Transport of each cargo is determined by recruitment of specific sets of motors and their regulation. Targeting of motors to membranes often depends on the formation of large multiprotein assemblies and can be influenced by membrane lipid composition. Motor activity can be regulated by cargo-induced conformational changes such as unfolding or dimerization. The architecture and function of motor: cargo complexes can also be controlled by phosphorylation, calcium signaling, and proteolysis. The complexity of transport systems is further increased by mechanical and functional cross-talk between different types of motors on the same cargo and by participation of the same motor in the movement of different organelles. Copyright 2010 Elsevier Ltd. All rights reserved.

  3. 46 CFR 154.412 - Cargo tank corrosion allowance.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo tank corrosion allowance. 154.412 Section 154.412... Containment Systems § 154.412 Cargo tank corrosion allowance. A cargo tank must be designed with a corrosion...) carries a cargo that corrodes the tank material. Note: Corrosion allowance for independent tank type C is...

  4. 46 CFR 151.13-5 - Cargo segregation-tanks.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo segregation-tanks. 151.13-5 Section 151.13-5... CARRYING BULK LIQUID HAZARDOUS MATERIAL CARGOES Cargo Segregation § 151.13-5 Cargo segregation—tanks. (a... and list the various degrees of segregation required. Paragraphs and (2) of this section explain the...

  5. 46 CFR 153.333 - Cargo pump discharge pressure gauge.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo pump discharge pressure gauge. 153.333 Section 153... Cargo Pumprooms § 153.333 Cargo pump discharge pressure gauge. Each cargo pump within a pump-room must have a discharge pressure gauge outside the pumproom. ...

  6. 46 CFR 98.30-11 - Cargo pumps.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Cargo pumps. 98.30-11 Section 98.30-11 Shipping COAST..., ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Portable Tanks § 98.30-11 Cargo pumps. No person may operate a cargo pump to transfer a product to or from a portable tank unless the pump...

  7. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its... the aluminum cargo tank must meet the steel structural standards of the American Bureau of Shipping...

  8. 29 CFR 1918.87 - Ship's cargo elevators.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Ship's cargo elevators. 1918.87 Section 1918.87 Labor... (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Handling Cargo § 1918.87 Ship's cargo elevators. (a) Safe working load. The safe working loads of ship's cargo elevators shall be determined and followed...

  9. 46 CFR 153.977 - Supervision of cargo transfer.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Supervision of cargo transfer. 153.977 Section 153.977 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS... Procedures § 153.977 Supervision of cargo transfer. The person in charge of cargo transfer shall: (a...

  10. Linking molecular motors to membrane cargo

    OpenAIRE

    Akhmanova, Anna; Hammer, John A.

    2010-01-01

    Three types of motors, myosins, kinesins and cytoplasmic dynein, cooperate to transport intracellular membrane organelles. Transport of each cargo is determined by recruitment of specific sets of motors and their regulation. Targeting of motors to membranes often depends on the formation of large multiprotein assemblies and can be influenced by membrane lipid composition. Motor activity can be regulated by cargo-induced conformational changes such as unfolding or dimerization. The architectur...

  11. Specialization and Flexibility in Port Cargo Handling

    Directory of Open Access Journals (Sweden)

    Hakkı KİŞİ

    2016-11-01

    Full Text Available Cargo handling appears to be the fundamental function of ports. In this context, the question of type of equipment and capacity rate need to be tackled with respect to cargo handling principles. The purpose of this study is to discuss the types of equipment to be used in ports, relating the matter to costs and capacity. The question is studied with a basic economic theoretical approach. Various conditions like port location, size, resources, cargo traffic, ships, etc. are given parameters to dictate the type and specification of the cargo handling equipment. Besides, a simple approach in the context of cost capacity relation can be useful in deciding whether to use specialized or flexible equipment. Port equipment is sometimes expected to be flexible to handle various types of cargo as many as possible and sometimes to be specialized to handle one specific type of cargo. The cases that might be suitable for those alternatives are discussed from an economic point of view in this article. Consequently, effectiveness and efficiency criteria play important roles in determining the handling equipment in ports.

  12. Metalclad substation subdivided into tight compartments

    Energy Technology Data Exchange (ETDEWEB)

    Diaferia, A.; Messie, M.

    1990-02-06

    This invention relates to a high voltage metalclad substation, having a metal enclosure, filled with a high dielectric strength gas, and subdivided into different compartments by tight insulating partitions. The object of this invention is to achieve a simplified substation of reduced dimensions preserving the possibilities of performing operations on part of the substation, while the other part remains live. According to the invention, a metalclad substation is provided, having a busbar isolating switch including an operating mechanism housed in the busbar compartment. The movable contacts of the isolating switch are housed in a compartment separated by a tight insulating partition from the busbar compartment. Tight partitioning of the compartments enables operations to be carried out in the different compartments while maintaining at least one of the busbars switched on to supply the unaffected part of the installation. The invention can be applied to a single-phase or a three-phase enclosure substation. 4 figs.

  13. Abdominal Compartment Syndrome due to OHSS

    Directory of Open Access Journals (Sweden)

    Firoozeh Veisi

    2012-03-01

    Full Text Available Abdominal compartment syndrome is a dangerous clinical situation, usually following abdominal injuries&operations. It is seldom observed in patients with gynecologic and obstetric problems. Abdominalcompartment syndrome may be consequence ovarian hyperstimulation syndrome. A 28-year-old womanpresented as a sever ovarian hyperstimulation.The increased IAP indicated that OHSS may beconsidered a compartment syndrome. Abdominal compartment syndrome needs laparotomy orparacentesis for reduction of pressure.

  14. Characterizing X-ray Attenuation of Containerized Cargo

    Energy Technology Data Exchange (ETDEWEB)

    Birrer, N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Divin, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Glenn, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Martz, H. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wang, G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-08-02

    X-ray inspection systems can be used to detect radiological and nuclear threats in imported cargo. In order to better understand performance of these systems, the attenuation characteristics of imported cargo need to be determined. This project focused on developing image processing algorithms for segmenting cargo and using x-ray attenuation to quantify equivalent steel thickness to determine cargo density. These algorithms were applied to over 450 cargo radiographs. The results are summarized in this report.

  15. Indirect estimation of radioactivity in containerized cargo

    International Nuclear Information System (INIS)

    Jarman, K.D.; Scherrer, C.; Smith, L.E.; Chilton, L.K.; Anderson, K.K.; Ressler, J.J.; Trease, L.L.

    2011-01-01

    Naturally occurring radioactive material in containerized cargo challenges the state of the art in national and international efforts to detect illicit nuclear and radiological material in transported containers. Current systems are being evaluated and new systems envisioned to provide the high probability of detection necessary to thwart potential threats, combined with extremely low nuisance and false alarm rates necessary to maintain the flow of commerce impacted by the enormous volume of commodities imported in shipping containers. Maintaining flow of commerce also means that inspection must be rapid, requiring relatively non-intrusive, indirect measurements of cargo from outside containers to the extent possible. With increasing information content in such measurements, it is natural to ask how the information might be combined to improve detection. Toward this end, we present an approach to estimating isotopic activity of naturally occurring radioactive material in cargo grouped by commodity type, combining container manifest data with radiography and gamma-ray spectroscopy aligned to location along the container. The heart of this approach is our statistical model of gamma-ray counts within peak regions of interest, which captures the effects of background suppression, counting noise, convolution of neighboring cargo contributions, and down-scattered photons to provide estimates of counts due to decay of specific radioisotopes in cargo alone. Coupled to that model, we use a mechanistic model of self-attenuated radiation flux to estimate the isotopic activity within cargo, segmented by location within each container, that produces those counts. We test our approach by applying it to a set of measurements taken at the Port of Seattle in 2006. This approach to synthesizing disparate available data streams and extraction of cargo characteristics, while relying on several simplifying assumptions and approximations, holds the potential to support improvement of

  16. Abdominal Compartment Syndrome in Surgical Patients

    African Journals Online (AJOL)

    CASE SERIES. Abstract. Background: The deleterious effects of intra- abdominal hypertension and abdominal compartment syndrome, affect almost every system ..... 148(1), 81–4. 14. Nacev TV. Abdominal Compartment Syndrome. In Multiple Trauma Patients With Concomitant. Abdominal and Head Lesions --Mechanisms.

  17. Compartmented mode workstation (CMW) comparisons

    Energy Technology Data Exchange (ETDEWEB)

    Tolliver, J.S.

    1995-12-31

    As the Compartmented Mode Workstation (CMW) market has matured, several vendors have released new versions of their CMW operating systems. These include a new version from SecureWare (CMW + Version 2.4), and Sun`s CMW 1.1 (also known as Trusted Solaris 1.1). EC is now shipping MLS+ 3.0 for DEC Alpha platforms. Relatively new entries in the market include Loral B1/CMW for IBM RS/6000 platforms and a SecureWare-based CMW for HP platforms (HP-UX 10.09). With all these choices it is time for a comparative analysis of the features offered by the various vendors. The authors have three of the above five CMW systems plus HP-UX BLS 9.09, which is a multilevel secure operating system (OS) targeted at the B1 level but not a CMW. Each is unique in sometimes obvious, sometimes subtle ways, a situation that requires knowing and keeping straight a variety of commands to do the same thing on each system. Some vendors offer extensive GUI tools for system administration; some require entering command-line commands for certain system administration tasks. They examine the differences in system installation, system administration, and system operating among the systems. They look at trusted networking among the various systems and differences in the network databases and label encodings files. They examine the user interface on the various systems from logging in to logging out.

  18. Optimization of the air cargo supply chain

    Directory of Open Access Journals (Sweden)

    María Pérez Bernal

    2012-10-01

    Full Text Available Purpose: This paper aims to evaluate and optimize the various operations within the air cargo chain. It pursues to improve the efficiency of the air cargo supply chain and to provide more information to the decision-makers to optimize their fields.Design/methodology/approach: The method used is a process simulation modelling software, WITNESS, which provides information to the decision-makers about the most relevant parameters subject to optimization. The input for the simulation is obtained from a qualitative analysis of the air cargo supply chain with the involved agents and from a study of the external trade by air mode, given that their behaviour depend on the location. The case study is focused on a particular location, the Case of Zaragoza Airport (Spain.Findings: This paper demonstrates that efficiency of the air cargo supply chain can increase by leveraging several parameters such as bottlenecks, resources or warehouses.Originality/value: It explores the use of a simulation modeling software originally intended for manufacturing processes and extended to support decision making processes in the area of air cargo.

  19. Cargo-mix optimization in Liner Shipping

    DEFF Research Database (Denmark)

    Christensen, Jonas Mark; Pacino, Dario; Fonseca, Joao Filipe Paiva

    International transportation constitutes one of the biggest challenges in limiting CO2 emission in theworld: it is technically hard to find viable alternatives to fossil fuels, and due to the internationalnature, it is very difficult to regulate CO2 emission of intercontinental trade. Moreover......’ utilization.The more containers a vessel carries the smaller is the resulting CO2 emissions per transported tonof cargo. This is what can be seen as a win-win situation. Better vessel utilization will result bothin cleaner transport and in better revenue margins for the shippers. Focus on vessel intake...... composition available in the different portsmight not be suitable for the full utilization of the vessel. The focus of our work is the analysis ofvessels’ cargo-mix, in particular finding what cargo composition is needed for a vessel to maximizeits utilization on a given service. Such a model can have various...

  20. Column generation approaches to ship scheduling with flexible cargo sizes

    DEFF Research Database (Denmark)

    Brønmo, Geir; Nygreen, Bjørn; Lysgaard, Jens

    2010-01-01

    We present a Dantzig-Wolfe procedure for the ship scheduling problem with flexible cargo sizes. This problem is similar to the well-known pickup and delivery problem with time windows, but the cargo sizes are defined by intervals instead of by fixed values. The flexible cargo sizes have consequen......We present a Dantzig-Wolfe procedure for the ship scheduling problem with flexible cargo sizes. This problem is similar to the well-known pickup and delivery problem with time windows, but the cargo sizes are defined by intervals instead of by fixed values. The flexible cargo sizes have...

  1. Characterizing Complexity of Containerized Cargo X-ray Images

    International Nuclear Information System (INIS)

    Wang, Guangxing; Martz, Harry; Glenn, Steven; Divin, Charles; Birrer, Nat

    2016-01-01

    X-ray imaging can be used to inspect cargos imported into the United States. In order to better understand the performance of X-ray inspection systems, the X-ray characteristics (density, complexity) of cargo need to be quantified. In this project, an image complexity measure called integrated power spectral density (IPSD) was studied using both DNDO engineered cargos and stream-of-commerce (SOC) cargos. A joint distribution of cargo density and complexity was obtained. A support vector machine was used to classify the SOC cargos into four categories to estimate the relative fractions.

  2. Port Security: Container Cargo Control

    Directory of Open Access Journals (Sweden)

    Vladivoj Vlaković

    2006-05-01

    Full Text Available illicittrafficking of threat materials, especially explosives, chemicalsubstances and radioactive or nuclear material. The transportof the threat materials by using sea routes is an advantageto te"orists especially because of the possible use of ship containers.The container is the basis of world trade. It is assumed thatthe world total movement in containers is about 200 millionTEUs ("20-foot equivalent units" per year. The list of materialstransported by containers which should be subject to inspectionwith the aim of reducing the acts of te"orism includes explosives,narcotics, chemical weapons, hazardous chemicalsand radioactive materials.Of special interest is nuclear te"orism. The risk of nuclearte"orism carried out by sub-national groups should be considerednot only in the construction and/or use of nuclear device,but also in possible radioactive contamination of large urbanareas.The system of ship containers control is an essential componentof «smart border» concept. Modem personnel, parcel,vehicle and cargo inspection systems are non-invasive imagingtechniques based on the use of nuclear analytical techniques.The inspection systems use penetrating radiations: hard x-rays(300 keV or more or gamma-rays from radioactive sources(137Cs and 60Co with energies from 600 to 1300 keV that producea high resolution radiograph of the load. Unfortunately,this information is "non-specific" in that it gives no informationon the nature of objects that do not match_ the travel documentsand are not recognized by a visual analysis of the radiographicpicture. Moreover, there are regions of the containerwherex and gamma-ray systems are "blind" due to the high averageatomic number of the objects i"adiated that appear asblack spots in the radiographic image.The systems being developed are based on the use of fast, 14Me V, neutrons with detection of associated a-particle from nuclearreactionbywhichneutrons are produced (d+t>a+n.Jnsuch a way the possibility to

  3. The bacterial carbon-fixing organelle is formed by shell envelopment of preassembled cargo.

    Directory of Open Access Journals (Sweden)

    Anna H Chen

    Full Text Available Cyanobacteria play a significant role in the global carbon cycle. In Synechococcuselongatus, the carbon-fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO is concentrated into polyhedral, proteinaceous compartments called carboxysomes.Using live cell fluorescence microscopy, we show that carboxysomes are first detected as small seeds of RuBisCO that colocalize with existing carboxysomes. These seeds contain little or no shell protein, but increase in RuBisCO content over several hours, during which time they are exposed to the solvent. The maturing seed is then enclosed by shell proteins, a rapid process that seals RuBisCO from the cytosol to establish a distinct, solvent-protected microenvironment that is oxidizing relative to the cytosol. These closure events can be spatially and temporally coincident with the appearance of a nascent daughter RuBisCO seed.Carboxysomes assemble in a stepwise fashion, inside-to-outside, revealing that cargo is the principle organizer of this compartment's biogenesis. Our observations of the spatial relationship of seeds to previously formed carboxysomes lead us to propose a model for carboxysome replication via sequential fission, polymerization, and encapsulation of their internal cargo.

  4. Video-based cargo fire verification system with fuzzy inference engine for commercial aircraft

    Science.gov (United States)

    Sadok, Mokhtar; Zakrzewski, Radek; Zeliff, Bob

    2005-02-01

    Conventional smoke detection systems currently installed onboard aircraft are often subject to high rates of false alarms. Under current procedures, whenever an alarm is issued the pilot is obliged to release fire extinguishers and to divert to the nearest airport. Aircraft diversions are costly and dangerous in some situations. A reliable detection system that minimizes false-alarm rate and allows continuous monitoring of cargo compartments is highly desirable. A video-based system has been recently developed by Goodrich Corporation to address this problem. The Cargo Fire Verification System (CFVS) is a multi camera system designed to provide live stream video to the cockpit crew and to perform hotspot, fire, and smoke detection in aircraft cargo bays. In addition to video frames, the CFVS uses other sensor readings to discriminate between genuine events such as fire or smoke and nuisance alarms such as fog or dust. A Mamdani-type fuzzy inference engine is developed to provide approximate reasoning for decision making. In one implementation, Gaussian membership functions for frame intensity-based features, relative humidity, and temperature are constructed using experimental data to form the system inference engine. The CFVS performed better than conventional aircraft smoke detectors in all standardized tests.

  5. 46 CFR 153.283 - Valving for cargo piping.

    Science.gov (United States)

    2010-10-01

    ... CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Piping Systems and Cargo Handling Equipment § 153.283 Valving for cargo piping. (a) Except as described in this...

  6. Marine cargo imports and forest pest introductions

    Science.gov (United States)

    Frank H. Koch

    2009-01-01

    A major pathway for the introduction of nonindigenous forest pests is accidental transport on cargo imported from overseas. Diseases may be brought into the United States via commercial trade of nursery stock or other live plant material, as has been suggested for Phytophthora ramorum, the pathogen that causes sudden oak death (Ivors and others 2006). Insects may...

  7. Molecular approach to intracellular cargo transport

    Science.gov (United States)

    Yildiz, Ahmet

    2010-03-01

    Landmark discoveries in the study of cytoplasmic motors have been made through advances in single molecule biophysics and detailed mechanistic models exist for kinesin and dynein. However, the function of motors in physiological conditions has not been carefully tested. In cells, more than few dyneins can attach to the same cargo and interact with the opposite polarity motors of kinesin. To study the molecular crosstalk between the motors, we have used intraflagellar transport (IFT) in Chlamydomonas reinhardtii as a model system. Ultrahigh spatio-temporal tracking of single cargo movement showed that IFT particles move for long distances unidirectionally with 8 nm increments, agreeing with measured step sizes of kinesin and dynein. To measure how many motors transport each cargo, we have linked large polystyrene beads to internal IFT particles through a transmembrane protein. Force measurements indicated that, on average, 3-4 motors transport cargoes in each direction. The results showed that IFT motors are tightly coordinated and might be involved in recycling each other to the appropriate end of the flagellum.

  8. Linking molecular motors to membrane cargo

    NARCIS (Netherlands)

    A.S. Akhmanova (Anna); J.A. Hammer (John)

    2010-01-01

    textabstractThree types of motors, myosins, kinesins, and cytoplasmic dynein, cooperate to transport intracellular membrane organelles. Transport of each cargo is determined by recruitment of specific sets of motors and their regulation. Targeting of motors to membranes often depends on the

  9. 49 CFR 38.127 - Sleeping compartments.

    Science.gov (United States)

    2010-10-01

    ...., heating and air conditioning controls, lighting controls, call buttons, electrical outlets, etc.) shall be... SPECIFICATIONS FOR TRANSPORTATION VEHICLES Intercity Rail Cars and Systems § 38.127 Sleeping compartments. (a...

  10. 48 CFR 52.228-9 - Cargo Insurance.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Cargo Insurance. 52.228-9... Insurance. As prescribed in 28.313(a), insert the following clause: Cargo Insurance (MAY 1999) (a) The..., cargo insurance of $_____ per vehicle to cover the value of property on each vehicle and of $_____ to...

  11. 77 FR 65006 - Air Cargo Advance Screening (ACAS) Pilot Program

    Science.gov (United States)

    2012-10-24

    ... electronic cargo information pursuant to the Trade Act, and has implemented this authority in 19 CFR 122.48a... pilot participants of a subset of mandatory advance electronic information for air cargo. CBP regulations implementing the Trade Act of 2002 require advance information for air cargo to be submitted no...

  12. 14 CFR 205.8 - Cargo liability disclosure statement.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Cargo liability disclosure statement. 205.8... PROCEEDINGS) ECONOMIC REGULATIONS AIRCRAFT ACCIDENT LIABILITY INSURANCE § 205.8 Cargo liability disclosure statement. Every direct U.S. or foreign air carrier providing air cargo service in air transportation shall...

  13. 46 CFR 154.1850 - Entering cargo handling spaces.

    Science.gov (United States)

    2010-10-01

    ..., compressors, and compressor motors. (2) Gas-dangerous cargo control spaces. (3) Other spaces containing cargo... cargo handling spaces. (a) The master shall ensure that the ventilation system under § 154.1200 is in... ventilation system, is posted outside of each space under paragraph (a) of this section. (c) The master shall...

  14. 46 CFR 154.1828 - Spaces containing cargo vapor: Entry.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Spaces containing cargo vapor: Entry. 154.1828 Section... Spaces containing cargo vapor: Entry. (a) No person may enter a cargo handling space without the... toxic vapors and has an oxygen concentration of at least 19.5 percent oxygen by volume; or (2) Those...

  15. 46 CFR 154.560 - Cargo hose: Prototype test.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo hose: Prototype test. 154.560 Section 154.560... Hose § 154.560 Cargo hose: Prototype test. (a) Each cargo hose must be of a type that passes a prototype test at a pressure of at least five times its maximum working pressure at or below the minimum...

  16. 46 CFR 154.1816 - Cargo location plan.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo location plan. 154.1816 Section 154.1816 Shipping... FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Operations § 154.1816 Cargo location plan. The master shall ensure that: (a) A cargo location plan is prepared that gives: (1) The location and...

  17. 46 CFR 151.25-2 - Cargo handling space.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo handling space. 151.25-2 Section 151.25-2 Shipping... BULK LIQUID HAZARDOUS MATERIAL CARGOES Environmental Control § 151.25-2 Cargo handling space. Pump rooms, compressor rooms, refrigeration rooms, heating rooms, instrument rooms or other closed spaces...

  18. 33 CFR 157.23 - Cargo and ballast system information.

    Science.gov (United States)

    2010-07-01

    ... CARRYING OIL IN BULK Design, Equipment, and Installation § 157.23 Cargo and ballast system information. (a... automatic and manual operation of the cargo and ballast system in the vessel. (b) The format and information... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Cargo and ballast system...

  19. Large eddy simulation of compartment fires

    Science.gov (United States)

    Trouvé, Arnaud; Wang, Yi

    2010-12-01

    This paper is aimed at illustrating the capabilities of contemporary large eddy simulation (LES) solvers for compartment fire applications. Compartment fires refer to fires occurring indoors and feature a variety of complex phenomena associated with smoke accumulation and restricted air ventilation. The article provides a brief presentation of the main features of compartment fire dynamics followed by a review of the modelling challenges found in a LES treatment of these dominant features. The discussion shows that in addition to a suitable model for the turbulent flow dynamics, simulations of compartment fires require a collection of physical sub-models in order to describe a large range of multi-physics phenomena, including pyrolysis processes, buoyancy-driven flow, combustion, soot formation and thermal radiation. Some examples of LES simulations of compartment fires are also presented, using two different solvers that represent the current state-of-the-art of compartment fire modelling: FDS developed by the National Institute of Standards and Technology, USA, and FireFOAM developed by FM Global, USA. Both solvers are available as free open-source software and are representative of ongoing efforts within the fire research and engineering community to self-organise and to promote the general area of LES-based fire modelling.

  20. 19 CFR 4.34 - Prematurely discharged, overcarried, and undelivered cargo.

    Science.gov (United States)

    2010-04-01

    ... forwarding cargo. When it is desired that prematurely landed cargo, overcarried cargo, or cargo so stowed as... substitute traveling manifest for the prematurely landed or overcarried cargo being forwarded as residue... forwarding is made on the Cargo Declaration, the new substitute traveling manifest shall be stamped to show...

  1. Aviation System Analysis Capability Air Carrier Investment Model-Cargo

    Science.gov (United States)

    Johnson, Jesse; Santmire, Tara

    1999-01-01

    The purpose of the Aviation System Analysis Capability (ASAC) Air Cargo Investment Model-Cargo (ACIMC), is to examine the economic effects of technology investment on the air cargo market, particularly the market for new cargo aircraft. To do so, we have built an econometrically based model designed to operate like the ACIM. Two main drivers account for virtually all of the demand: the growth rate of the Gross Domestic Product (GDP) and changes in the fare yield (which is a proxy of the price charged or fare). These differences arise from a combination of the nature of air cargo demand and the peculiarities of the air cargo market. The net effect of these two factors are that sales of new cargo aircraft are much less sensitive to either increases in GDP or changes in the costs of labor, capital, fuel, materials, and energy associated with the production of new cargo aircraft than the sales of new passenger aircraft. This in conjunction with the relatively small size of the cargo aircraft market means technology improvements to the cargo aircraft will do relatively very little to spur increased sales of new cargo aircraft.

  2. Iliopsoas compartment lesions: a radiologic evaluation

    International Nuclear Information System (INIS)

    Leao, Alberto Ribeiro de Souza; Amaral, Raquel Portugal Guimaraes; Abud, Thiago Giansante; Demarchi, Guilherme Tadeu Sauaia; Freire Filho, Edison de Oliveira; Novack, Paulo Rogerio; Campos, Flavio do Amaral; Shigueoka, David Carlos; Fernandes, Artur da Rocha Correa; Szejnfeld, Jacob; D'Ippolito, Giuseppe

    2007-01-01

    The iliopsoas compartment, a posterior boundary of the retroperitoneum, is comprised of the psoas major, psoas minor and iliac muscles. The symptoms picture in patients presenting with pathological involvement of this compartment may show a wide range of nonspecific clinical presentations that may lead to delayed diagnosis. However, in the search of an etiological diagnosis, it is already known that inflammation, tumors, and hemorrhages account for almost all the lesions affecting the iliopsoas compartment. By means of a retrospective analysis of radiological studies in patients with iliopsoas compartment lesions whose diagnosis was confirmed by anatomopathological evaluation or clinical follow-up, we have reviewed its anatomy as well as the main forms of involvement, with the purpose of identifying radiological signs that may help to narrow down the potential differential diagnoses. As each lesion is approached we will discuss the main radiological findings such as presence of gas in pyogenic abscesses, bone destruction and other bone changes of vertebral bodies in lesions secondary to tuberculosis, involvement of fascial planes in cases of neoplasms, and differences in signal density and intensity of hematomas secondary to hemoglobin degradation, among others. So, we have tried to present cases depicting the most frequent lesions involving the iliopsoas compartment, with emphasis on those signs that can lead us to a more specific etiological diagnosis. (author)

  3. Iliopsoas compartment lesions: a radiologic evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Leao, Alberto Ribeiro de Souza; Amaral, Raquel Portugal Guimaraes; Abud, Thiago Giansante; Demarchi, Guilherme Tadeu Sauaia; Freire Filho, Edison de Oliveira; Novack, Paulo Rogerio; Campos, Flavio do Amaral; Shigueoka, David Carlos; Fernandes, Artur da Rocha Correa; Szejnfeld, Jacob; D' Ippolito, Giuseppe [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil). Dept. de Diagnostico por Imagem]. E-mail: ar.leao@uol.com.br; Santos, Jose Eduardo Mourao [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil)

    2007-07-15

    The iliopsoas compartment, a posterior boundary of the retroperitoneum, is comprised of the psoas major, psoas minor and iliac muscles. The symptoms picture in patients presenting with pathological involvement of this compartment may show a wide range of nonspecific clinical presentations that may lead to delayed diagnosis. However, in the search of an etiological diagnosis, it is already known that inflammation, tumors, and hemorrhages account for almost all the lesions affecting the iliopsoas compartment. By means of a retrospective analysis of radiological studies in patients with iliopsoas compartment lesions whose diagnosis was confirmed by anatomopathological evaluation or clinical follow-up, we have reviewed its anatomy as well as the main forms of involvement, with the purpose of identifying radiological signs that may help to narrow down the potential differential diagnoses. As each lesion is approached we will discuss the main radiological findings such as presence of gas in pyogenic abscesses, bone destruction and other bone changes of vertebral bodies in lesions secondary to tuberculosis, involvement of fascial planes in cases of neoplasms, and differences in signal density and intensity of hematomas secondary to hemoglobin degradation, among others. So, we have tried to present cases depicting the most frequent lesions involving the iliopsoas compartment, with emphasis on those signs that can lead us to a more specific etiological diagnosis. (author)

  4. Cargo transportation by airships: A systems study

    Science.gov (United States)

    Huang, C. J.; Dalton, C.

    1976-01-01

    A systems engineering study of a lighter than air airship transportation system was conducted. The feasibility of the use of airships in hauling cargo was demonstrated. Social, legal, environmental and political factors were considered as well as the technical factors necessary to design an effective airship transportation system. In order to accomplish an effective airship transportation program two phases of implementation were recommended. Phase I would involve a fleet of rigid airships of 3.5 million cubic feet displacement capable of carrying 25 tons of cargo internal to the helium-filled gas bag. The Phase I fleet would demonstrate the economic and technical feasibility of modern-day airships while providing a training capability for the construction and operation of larger airships. The Phase II portion would be a fleet of rigid airships of 12 million cubic feet displacement capable of carrying a cargo of 100 tons a distance of 2,000 miles at a cruising speed of 60 mph. An economic analysis is given for a variety of missions for both Phase I and Phase II airships.

  5. Sorting of cargos between axons and dendrites: modelling of differences in cargo transport in these two types of neurites.

    Science.gov (United States)

    Kuznetsov, A V

    2014-05-01

    Explaining how intracellular cargos are sorted between axons and dendrites is important for a mechanistic understanding of what happens in many neurodegenerative disorders. A simple model of cargo sorting relies on differences in microtubule (MT) orientation between axons and dendrites: in mammalian neurons all MTs in axons have their plus ends directed outward while in proximal regions of dendrites the MT polarity is mixed. It can therefore be assumed that cargos that need to be driven into axons associate with kinesin motors while cargos that need to be driven into dendrites associate with dynein motors. This paper develops equations of cargo transport in axons and dendrites based on the above assumptions. Propagation of a pulse of radiolabelled cargos entering an axon and dendrite is simulated. The model equations are solved utilising the Laplace transform method. Differences in cargo transport between axons and dendrites are discussed.

  6. Effects of combustible stacking in large compartments

    DEFF Research Database (Denmark)

    Gentili, Filippo; Giuliani, Luisa; Bontempi, Franco

    2013-01-01

    This paper focuses on the modelling of fire in case of various distributions of combustible materials in a large compartment. Large compartments often represent a challenge for structural fire safety, because of lack of prescriptive rules to follow and difficulties of taking into account the effect...... to different stacking configurations of the pallets with the avail of a CFD code. The results in term of temperatures of the hot gasses and of the steel elements composing the structural system are compared with simplified analytical model of localized and post-flashover fires, with the aim of highlighting...

  7. Gluteal Compartment Syndrome Secondary to Pelvic Trauma

    Directory of Open Access Journals (Sweden)

    Fernando Diaz Dilernia

    2016-01-01

    Full Text Available Gluteal compartment syndrome (GCS is extremely rare when compared to compartment syndrome in other anatomical regions, such as the forearm or the lower leg. It usually occurs in drug users following prolonged immobilization due to loss of consciousness. Another possible cause is trauma, which is rare and has only few reports in the literature. Physical examination may show tense and swollen buttocks and severe pain caused by passive range of motion. We present the case of a 70-year-old man who developed GCS after prolonged anterior-posterior pelvis compression. The physical examination revealed swelling, scrotal hematoma, and left ankle extension weakness. An unstable pelvic ring injury was diagnosed and the patient was taken to surgery. Measurement of the intracompartmental pressure was measured in the operating room, thereby confirming the diagnosis. Emergent fasciotomy was performed to decompress the three affected compartments. Trauma surgeons must be aware of the possibility of gluteal compartment syndrome in patients who have an acute pelvic trauma with buttock swelling and excessive pain of the gluteal region. Any delay in diagnosis or treatment can be devastating, causing permanent disability, irreversible loss of gluteal muscles, sciatic nerve palsy, kidney failure, or even death.

  8. Abdominal Compartment Syndrome in Surgical Patients | Muturi ...

    African Journals Online (AJOL)

    Background: The deleterious effects of intraabdominal hypertension and abdominal compartment syndrome, affect almost every system. Patients at risk are the critically ill, in whom it leads to alteredorgan perfusion and end organ dysfunction/failure. The five cases reported highlight the diagnostic and management ...

  9. Assembly and Mechanical Properties of the Cargo-Free and Cargo-Loaded Bacterial Nanocompartment Encapsulin

    NARCIS (Netherlands)

    Snijder, Joost|info:eu-repo/dai/nl/338018328; Kononova, Olga; Barbu, Ioana M|info:eu-repo/dai/nl/313937532; Uetrecht, Charlotte|info:eu-repo/dai/nl/304824623; Rurup, W Frederik; Koay, Melissa S T; Burnley, Rebecca J; Cornelissen, Jeroen J L M; Roos, Wouter H; Barsegov, Valeri; Wuite, Gijs J L; Heck, Albert J R|info:eu-repo/dai/nl/105189332

    2016-01-01

    Prokaryotes mostly lack membranous compartments that are typical of eukaryotic cells, but instead, they have various protein-based organelles. These include bacterial microcompartments like the carboxysome and the virus-like nanocompartment encapsulin. Encapsulins have an adaptable mechanism for

  10. Assembly and Mechanical Properties of the Cargo-Free and Cargo Loaded Bacterial Nanocompartment Encapsulin

    NARCIS (Netherlands)

    Snijder, J.; Kononova, O.; Barbu, I.M.; Uetrecht, C.; Rurup, W.F.; Koay, M.S.T.; Cornelissen, J.J.L.M.; Roos, W.H.; Barsegov, V.; Wuite, G.J.L.; Heck, A.J.R.

    2016-01-01

    Prokaryotes mostly lack membranous compartments that are typical of eukaryotic cells, but instead, they have various protein-based organelles. These include bacterial microcompartments like the carboxysome and the virus-like nanocompartment encapsulin. Encapsulins have an adaptable mechanism for

  11. Assembly and mechanical properties of the cargo-free and cargo-loaded bacterial nanocompartment encapsulin

    NARCIS (Netherlands)

    Snijder, Joost; Kononova, Olga; Barbu, Ioana M; Uetrecht, Charlotte; Rurup, W Frederik; Burnley, Rebecca J; Koay, Melissa S T; Cornelissen, Jeroen J L M; Roos, Wouter H; Barsegov, Valeri; Wuite, Gijs J L; Heck, Albert J R

    2016-01-01

    Prokaryotes mostly lack membranous compartments that are typical of eukaryotic cells, but instead they have various protein-based organelles. These include bacterial microcompartments like the carboxysome and the virus-like nanocompartment encapsulin. Encapsulins have an adaptable mechanism for

  12. STRATEGIC MANAGEMENT OF TRANSPORT CARGO COMPLEX

    Directory of Open Access Journals (Sweden)

    A. M. Okorokov

    2014-06-01

    Full Text Available Purpose. Making the qualitative administrative decisions defining strategy and tactics of transport cargo complexes development, and also its subsystems, is possible only in the presence of flexible optimization model. This model has to consider multiparametricity and multicriteriality of the given task, uncertainty and vagueness of input information, and also to provide process automation of searching the best parameters of the given production facility. The purpose of the research is to develop procedures for the strategic management of complex with view of the most important factors and their stochastic nature, which will execute the improvement of technical equipment of TCC. Methodology. The problem of strategic management is based on solving the complex of issues of the optimal number of shunting locomotives, optimal processing capability of handling the front and rational capacity of warehouses. The problem is solved on the basis of the proposed optimality criterion – the specific set of profit per unit of capital assets of freight industry. The listed problems are solved using simulation modeling of the freight industry. Findings. The use of developed procedure allows one to improve the technical equipment of the freight stations and complexes. Originality. For the first time it was developed the procedure of strategic management of development. This procedure allows taking into account the probabilistic nature of demand for services of transport freight complexes and technological processes of client services on the complex stations. The proposed procedure can be applied during when planning the investments in the creation of transport freight complexes. Practical value. Use as a basic tool of simulation models of complex cargo operation allows estimating the effectiveness of the capital investments, the level of operating costs, as well as the quality of meeting the demands of potential customers in transportations at the stage of

  13. Cargo distributions differentiate pathological axonal transport impairments.

    Science.gov (United States)

    Mitchell, Cassie S; Lee, Robert H

    2012-05-07

    Axonal transport is an essential process in neurons, analogous to shipping goods, by which energetic and cellular building supplies are carried downstream (anterogradely) and wastes are carried upstream (retrogradely) by molecular motors, which act as cargo porters. Impairments in axonal transport have been linked to devastating and often lethal neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis, Huntington's, and Alzheimer's. Axonal transport impairment types include a decrease in available motors for cargo transport (motor depletion), the presence of defective or non-functional motors (motor dilution), and the presence of increased or larger cargos (protein aggregation). An impediment to potential treatment identification has been the inability to determine what type(s) of axonal transport impairment candidates that could be present in a given disease. In this study, we utilize a computational model and common axonal transport experimental metrics to reveal the axonal transport impairment general characteristics or "signatures" that result from three general defect types of motor depletion, motor dilution, and protein aggregation. Our results not only provide a means to discern these general impairments types, they also reveal key dynamic and emergent features of axonal transport, which potentially underlie multiple impairment types. The identified characteristics, as well as the analytical method, can be used to help elucidate the axonal transport impairments observed in experimental and clinical data. For example, using the model-predicted defect signatures, we identify the defect candidates, which are most likely to be responsible for the axonal transport impairments in the G93A SOD1 mouse model of ALS. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. Installation of the Canadian Muon Cargo Inspection System at CRL

    Science.gov (United States)

    2014-04-01

    Installation of the Canadian Muon Cargo Inspection System at CRL Prepared by: Guy Jonkmans Atomic Energy of Canada Limited Chalk River ON...INSTALLATION OF THE CANADIAN MUON CARGO INSPECTION SYSTEM AT CRL 153-30100-REPT-001 Revision 0 2013/02/19 UNRESTRICTED 2013/02/19 ILLIMITÉ 153...30100-REPT-001 2013/02/19 Report, General Installation of the Canadian Muon Cargo Inspection System at CRL Research and Development 153-30100

  15. Leg 201Tl-SPECT in chronic exertional compartment syndrome

    International Nuclear Information System (INIS)

    Elkadri, N.; Slim, I.; Blondet, C.; Choquet, Ph.; Constantinesco, A.; Lecocq, J.

    2004-01-01

    Leg 201 Tl-SPECT in chronic exertional compartment syndrome Background: The chronic exertional compartment syndrome is one of the most frequent origins regarding leg pain due to sport training. The diagnosis can be established by invasive compartment pressure measurement. The aim of this study is to evaluate the role that could have 201 Tl-SPECT for patients with suspicion of compartment syndrome. Patients and methods: 51 leg 201 Tl-SPECT exams were performed (exercise - and rest without reinjection) in 49 patients; 28 had compartment syndrome confirmed by pressure measurement. About 100 MBq of 201 Tl were injected during exercise, when pain appeared or at least after 25 minutes exercise. We studied mean percentages of level uptake for each compartment, referred to the maximal uptake of both legs. Results: 47 compartments were concerned by compartment syndrome and 361 compartments were not. Scintigraphic patterns in compartments are reversible ischaemia (45%), uptake stability (36%) or reverse redistribution (19%); these patterns are not linked to compartment syndrome. However, there is a significant difference of rest 201 Tl level uptake between compartments with and without compartment syndrome and a significant correlation between muscular pressure measurement and rest level uptake. Conclusion: 201 Tl-SPECT shows that only ischaemia does not explain compartment syndrome. Moreover, it allows to predict pressure variation during exercise but it does not offer any interest in order to select patients for muscular invasive pressure measurement. (author)

  16. The carriage of dangerous and nuclear cargoes

    International Nuclear Information System (INIS)

    King, P.E.

    1986-01-01

    In an area of real public concern it is regrettable that the applicable principles of legal liability at common law are not certain nor readily adaptable to admittedly remarkable technological change. Whilst the ever-flexible principle of negligence suggests a way forward, in the case of totally destructive cargoes or where evidence of fault may be scarce, principles of strict liability find a necessary operation. This is the approach reflected in the international codes referred to, especially in the area of uranium-related activities which Australia has not yet adopted

  17. Plant PRA plays an important role in intracellular vesicular trafficking between compartments as GDF.

    Science.gov (United States)

    Bahk, Jeong Dong; Bang, Woo Young; Heo, Jae Bok

    2009-11-01

    Rab GTPases like Ras-related monomeric GTPases are well known to regulate intracellular vesicle trafficking by cycling between membrane-bound and cytosolic states. The functions of these proteins are controlled by upstream regulators and downstream effectors. Ypt/Rabs transmit signals to downstream effectors in a GTP-dependent manner. GDP-bound Rab proteins are extracted from their target membrane by cytosolic proteins known as GDP dissociation inhibitors (GDIs), and the Rab GTPase is recruited to the membrane compartment following dissociation from the GDI by GDI displacement factor (GDF). Now, we're going to discuss the role of plant PRA concerted with Rab and GDI proteins by recycling Rab between membrane and cytosol for intracellular trafficking of cargo proteins.

  18. Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites.

    Science.gov (United States)

    Lång, Anna; Eriksson, Jens; Schink, Kay Oliver; Lång, Emma; Blicher, Pernille; Połeć, Anna; Brech, Andreas; Dalhus, Bjørn; Bøe, Stig Ove

    2017-07-04

    Selective nuclear import in eukaryotic cells involves sequential interactions between nuclear import receptors and phenylalanine-glycine (FG)-repeat nucleoporins. Traditionally, binding of cargoes to import receptors is perceived as a nuclear pore complex independent event, while interactions between import complexes and nucleoporins are thought to take place at the nuclear pores. However, studies have shown that nucleoporins are mobile and not static within the nuclear pores, suggesting that they may become engaged in nuclear import before nuclear pore entry. Here we have studied post-mitotic nuclear import of the tumor suppressor protein PML. Since this protein forms nuclear compartments called PML bodies that persist during mitosis, the assembly of putative PML import complexes can be visualized on the surface of these protein aggregates as the cell progress from an import inactive state in mitosis to an import active state in G1. We show that these post-mitotic cytoplasmic PML bodies incorporate a multitude of peripheral nucleoporins, but not scaffold or nuclear basket nucleoporins, in a manner that depends on FG-repeats, the KPNB1 import receptor, and the PML nuclear localization signal. The study suggests that nucleoporins have the ability to target certain nuclear cargo proteins in a nuclear pore-uncoupled state, before nuclear pore entry.

  19. Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE Underlies Irreversible Blinding Diseases

    Directory of Open Access Journals (Sweden)

    Eloise Keeling

    2018-02-01

    Full Text Available Chronic degeneration of the Retinal Pigment Epithelium (RPE is a precursor to pathological changes in the outer retina. The RPE monolayer, which lies beneath the neuroretina, daily internalises and digests large volumes of spent photoreceptor outer segments. Impaired cargo handling and processing in the endocytic/phagosome and autophagy pathways lead to the accumulation of lipofuscin and pyridinium bis-retinoid A2E aggregates and chemically modified compounds such as malondialdehyde and 4-hydroxynonenal within RPE. These contribute to increased proteolytic and oxidative stress, resulting in irreversible damage to post-mitotic RPE cells and development of blinding conditions such as age-related macular degeneration, Stargardt disease and choroideremia. Here, we review how impaired cargo handling in the RPE results in their dysfunction, discuss new findings from our laboratory and consider how newly discovered roles for lysosomes and the autophagy pathway could provide insights into retinopathies. Studies of these dynamic, molecular events have also been spurred on by recent advances in optics and imaging technology. Mechanisms underpinning lysosomal impairment in other degenerative conditions including storage disorders, α-synuclein pathologies and Alzheimer’s disease are also discussed. Collectively, these findings help transcend conventional understanding of these intracellular compartments as simple waste disposal bags to bring about a paradigm shift in the way lysosomes are perceived.

  20. 46 CFR 153.1052 - Carriage of other cargoes in acid tanks.

    Science.gov (United States)

    2010-10-01

    ... Special Cargo Procedures § 153.1052 Carriage of other cargoes in acid tanks. No person shall load or carry other cargoes in a cargo containment system of a U.S. flag ship endorsed to carry sulfuric acid... 46 Shipping 5 2010-10-01 2010-10-01 false Carriage of other cargoes in acid tanks. 153.1052...

  1. Retromer subunits VPS35A and VPS29 mediate prevacuolar compartment (PVC) function in Arabidopsis.

    Science.gov (United States)

    Nodzynski, Tomasz; Feraru, Mugurel I; Hirsch, Sibylle; De Rycke, Riet; Niculaes, Claudiu; Boerjan, Wout; Van Leene, Jelle; De Jaeger, Geert; Vanneste, Steffen; Friml, Jirí

    2013-11-01

    Intracellular protein routing is mediated by vesicular transport which is tightly regulated in eukaryotes. The protein and lipid homeostasis depends on coordinated delivery of de novo synthesized or recycled cargoes to the plasma membrane by exocytosis and their subsequent removal by rerouting them for recycling or degradation. Here, we report the characterization of protein affected trafficking 3 (pat3) mutant that we identified by an epifluorescence-based forward genetic screen for mutants defective in subcellular distribution of Arabidopsis auxin transporter PIN1-GFP. While pat3 displays largely normal plant morphology and development in nutrient-rich conditions, it shows strong ectopic intracellular accumulations of different plasma membrane cargoes in structures that resemble prevacuolar compartments (PVC) with an aberrant morphology. Genetic mapping revealed that pat3 is defective in vacuolar protein sorting 35A (VPS35A), a putative subunit of the retromer complex that mediates retrograde trafficking between the PVC and trans-Golgi network. Similarly, a mutant defective in another retromer subunit, vps29, shows comparable subcellular defects in PVC morphology and protein accumulation. Thus, our data provide evidence that the retromer components VPS35A and VPS29 are essential for normal PVC morphology and normal trafficking of plasma membrane proteins in plants. In addition, we show that, out of the three VPS35 retromer subunits present in Arabidopsis thaliana genome, the VPS35 homolog A plays a prevailing role in trafficking to the lytic vacuole, presenting another level of complexity in the retromer-dependent vacuolar sorting.

  2. Multi-compartment Aerosol Transport Model

    Energy Technology Data Exchange (ETDEWEB)

    Hubbard, Joshua Allen; Santarpia, Joshua; Brotherton, Christopher M.; Omana, Michael Alexis; Rivera, Danielle; Lucero, Gabriel Anthony

    2017-06-01

    A simple aerosol transport model was developed for a multi-compartmented cleanroom. Each compartment was treated as a well-mixed volume with ventilating supply and return air. Gravitational settling, intercompartment transport, and leakage of exterior air into the system were included in the model. A set of first order, coupled, ordinary differential equations was derived from the conservation equations of aerosol mass and air mass. The system of ODEs was then solved in MATLAB using pre-existing numerical methods. The model was verified against cases of (1) constant inlet-duct concentration, and (2) exponentially decaying inlet-duct concentration. Numerical methods resulted in normalized error of less than 10 -9 when model solutions were compared to analytical solutions. The model was validated against experimental measurements from a single field test and showed good agreement in the shape and magnitude of the aerosol concentration profile with time.

  3. A modern definition of mediastinal compartments.

    Science.gov (United States)

    Carter, Brett W; Tomiyama, Noriyuki; Bhora, Faiz Y; Rosado de Christenson, Melissa L; Nakajima, Jun; Boiselle, Phillip M; Detterbeck, Frank C; Marom, Edith M

    2014-09-01

    Division of the mediastinum into compartments is used to help narrow the differential diagnosis of newly detected mediastinal masses, to assist in planning biopsy and surgical procedures, and to facilitate communication among clinicians of multiple disciplines. Several traditional mediastinal division schemes exist based upon arbitrary landmarks on the lateral chest radiograph. We describe a modern, computed tomography-based mediastinal division scheme, which has been accepted by the International Thymic Malignancy Interest Group as a new standard. This clinical classification defines a prevascular (anterior), a visceral (middle), and a paravertebral (posterior) compartment, with anatomic boundaries defined clearly by computed tomography. It is our intention that this definition be used in the reporting of clinical cases and the design of prospective clinical trials.

  4. Hermetic compartments leak-tightness enhancement

    International Nuclear Information System (INIS)

    Murani, J.

    2000-01-01

    In connection with the enhancement of the nuclear safety of the Jaslovske Bohunice V-1 NPP actions for the increase of the leak tightness are performed. The reconstruction has been done in the following directions: hermetic compartments leak tightness enhancement; air lock installation; installation of air lock in SP 4 vent system; integrated leakage rate test to hermetic compartments with leak detection. After 'major' leaks on the hermetic boundary components had been eliminated, since 1994 works on a higher qualitative level began. The essence of the works consists in the detection and identification of leaks in the structural component of the hermetic boundary during the planned refueling outages. The results of the Small Reconstruction and gradual enhancement of leak tightness are presented

  5. Perfluoroalkyl acid distribution in various plant compartments ...

    Science.gov (United States)

    Crop uptake of perfluoroalkyl acids (PFAAs) from biosolids-amended soil has been identified as a potential pathway for PFAA entry into the terrestrial food chain. This study compared the uptake of PFAAs in greenhouse-grown radish (Raphanus sativus), celery (Apium graveolens var.dulce), tomato (Lycopersicon lycopersicum), and sugar snap pea (Pisum sativum var. macrocarpon) from an industrially impacted biosolids-amended soil, a municipal biosolids­ amended soil, and a control soil. Individual concentrations of PFAAs, on a dry weight basis, in mature, edible portions of crops grown in soil amended with PFAA industrially impacted biosolids were highest for perfluorooctanoate (PFOA; 67 ng/g) in radish root, perfluorobutanoate (PFBA;232 ng/g) in celery shoot, and PFBA (150 ng/g) in pea fruit. Comparatively, PFAA concentrations in edible compartments of crops grown in the municipal biosolids-amended soil and in the control soil were less than 25 ng/g. Bioaccumulation factors (BAFs) were calculated for the root, shoot, and fruit compartments (as applicable) of all crops grown in the industrially impacted soil. BAFs were highest for PFBA in the shoots of all crops, as well as in the fruit compartment of pea. Root­ soil concentration factors (RCFs) for tomato and pea were independent of PFAA chain length, while radish and celery RCFs showed a slight decrease with increasing chain length. Shoot-soil concentration factors (SCFs) for all crops showed a decrease with incre

  6. The pathophysiology of the acute compartment syndrome.

    Science.gov (United States)

    Tollens, T; Janzing, H; Broos, P

    1998-08-01

    The acute compartment syndrome is a condition in which increased pressure within a limited space compromises the circulation and function of the tissues therein, resulting in tissue ischaemia, necrosis and nerve damage. This rise in tissue pressure originates in a decrease of the compartment size or increase of the intracompartmental volume by oedema and/or haemorrhage. Following the arterio-venous gradient theory, capillary blood flow may be impaired through increased venous pressure, decreased arterial pressure and increased peripheral vascular resistance. Often, compartment syndromes develop during reperfusion following a period of ischaemia. During ischaemia, there is a gradual depletion of intracellular stores of high energy phosphate bonds and glycogen stores. There is a buildup of products of glycolysis, particularly lactic acid, with accompanying hydrogen ion accumulation as well as an increase in intracellular reducing agents. Reperfusion may, instead of restoring normal muscle metabolic activity, cause harmful effects by washing out necessary precursors for adenine nucleotide resynthesis. Production of oxygen free radicals occurs with ensuing lipid peroxidation, and calcium influx occurs upon reoxygenation with resultant disruption of oxidative rephosphorylation in the mitochondria. Furthermore, several lines of evidence suggest that white blood cells are important in the pathogenesis of reperfusion injury. Upregulation of both neutrophil receptors and endothelial leucocyte adhesion molecules leads to the sequestration of white blood cells in the muscle with prolongation of the reperfusion injury. This subsequently results in damage to remote organs such as lungs, liver, heart and kidneys.

  7. Compartment syndrome can also be seen in the forearm

    DEFF Research Database (Denmark)

    Asmar, Ali; Broholm, Rikke; Bülow, Jens

    2014-01-01

    Chronic compartment syndrome is a challenge for the clinician and symptomatic similar to neuropathies, tenosynovitis, stress fractures and referred pain from lumbar cervicalis. Thus, chronic compartment syndrome of the upper extremities is probably an underdiagnosed condition. In patients...

  8. Random walks of cytoskeletal motors in open and closed compartments

    NARCIS (Netherlands)

    Lipowsky, R.; Klumpp, S.

    2001-01-01

    Random walks of molecular motors, which bind to and unbind from cytoskeletal filaments, are studied theoretically. The bound and unbound motors undergo directed and nondirected motion, respectively. Motors in open compartments exhibit anomalous drift velocities. Motors in closed compartments

  9. Computed tomography of the cervical compartments on the computer tomogram

    Energy Technology Data Exchange (ETDEWEB)

    Zaunbauer, W.; Haertel, M.

    1984-02-01

    The computed tomographic anatomy of the cervical compartments, with emphasis on the fascial planes of the neck, is described. Typical disease processes within these fascial confined compartments have been documented.

  10. Column generation approaches to ship scheduling with flexible cargo sizes

    DEFF Research Database (Denmark)

    Brønmo, Geir; Nygreen, Bjørn; Lysgaard, Jens

    We present a Dantzig-Wolfe procedure for the ship scheduling problem with flexible cargo sizes. This problem is similar to the well-known pickup and delivery problem with time windows, but the cargo sizes are defined by an interval instead of a fixed value. We show that the introduction of flexible...

  11. 33 CFR 401.76 - In-transit cargo.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false In-transit cargo. 401.76 Section... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Toll Assessment and Payment § 401.76 In-transit cargo... the Seaway Transit Declaration Form, but is deemed to be ballast and not subject to toll assessment. ...

  12. 19 CFR 4.62 - Accounting for inward cargo.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Accounting for inward cargo. 4.62 Section 4.62 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY VESSELS IN FOREIGN AND DOMESTIC TRADES Foreign Clearances § 4.62 Accounting for inward cargo...

  13. 19 CFR 4.33 - Diversion of cargo.

    Science.gov (United States)

    2010-04-01

    ...) Substitution of ports of discharge on manifest. After entry, the Cargo Declaration, Customs Form 1302, of a... Declaration, under oath, covering the cargo, which it is desired to divert, is furnished in support of the... purposes; and (3) The certified traveling manifest is not altered or added to in any way by the master...

  14. Basic mechanisms for recognition and transport of synaptic cargos

    NARCIS (Netherlands)

    M.A. Schlager (Max); C.C. Hoogenraad (Casper)

    2009-01-01

    textabstractSynaptic cargo trafficking is essential for synapse formation, function and plasticity. In order to transport synaptic cargo, such as synaptic vesicle precursors, mitochondria, neurotransmitter receptors and signaling proteins to their site of action, neurons make use of molecular motor

  15. 46 CFR 151.50-5 - Cargoes having toxic properties.

    Science.gov (United States)

    2010-10-01

    ... gauge pressure exceeding 4 pounds per square inch, or where air or water pressure is used to discharge... cargo tanks shall be designed for a pressure not less than the vapor pressure, in pounds per square inch gauge, of the lading at 115 °F, or the maximum air or water pressure used to discharge the cargo...

  16. 46 CFR 151.15-10 - Cargo gauging devices.

    Science.gov (United States)

    2010-10-01

    ..., cargoes carried under pressure shall have restricted gauging devices designed so that the maximum bleed... (protected), electronic probe, magnetic, differential pressure cell. (d) Isolated or indirect. A gauging... shall be designed for the pressure and temperature of the cargo in accordance with the requirements of...

  17. 46 CFR 153.440 - Cargo temperature sensors.

    Science.gov (United States)

    2010-10-01

    ... Temperature Control Systems § 153.440 Cargo temperature sensors. (a) Except as prescribed in paragraph (c) of this section, when Table 1 refers to this section, the containment system must meet the following... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo temperature sensors. 153.440 Section 153.440...

  18. 33 CFR 157.19 - Cargo tank arrangement and size.

    Science.gov (United States)

    2010-07-01

    ... OIL IN BULK Design, Equipment, and Installation § 157.19 Cargo tank arrangement and size. (a) This... of connection to the tank served to prevent oil outflow in the event of damage to the piping; and (2... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Cargo tank arrangement and size...

  19. 33 CFR 157.132 - Cargo tanks: Hydrocarbon vapor emissions.

    Science.gov (United States)

    2010-07-01

    ... CARRYING OIL IN BULK Crude Oil Washing (COW) System on Tank Vessels Design, Equipment, and Installation... cargo tank that is discharging crude oil; or (b) Any other means accepted by the Commandant that... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Cargo tanks: Hydrocarbon vapor...

  20. 33 CFR 157.134 - Cargo tank drainage.

    Science.gov (United States)

    2010-07-01

    ...) POLLUTION RULES FOR THE PROTECTION OF THE MARINE ENVIRONMENT RELATING TO TANK VESSELS CARRYING OIL IN BULK Crude Oil Washing (COW) System on Tank Vessels Design, Equipment, and Installation § 157.134 Cargo tank drainage. Each cargo tank must be designed for longitudinal and transverse drainage of crude oil to allow...

  1. Cargo/Logistics Airlift System Study (CLASS), Volume 2

    Science.gov (United States)

    Norman, J. M.; Henderson, R. D.; Macey, F. C.; Tuttle, R. P.

    1978-01-01

    Air containerization is discussed in terms of lower freight rates, size and pallet limitations, refrigeration, backhaul of empties, and ownership. It is concluded that there is a need for an advance air cargo system as indicated by the industry/transportation case studies, and a stimulation of the air cargo would result in freight rate reductions.

  2. 49 CFR 1549.101 - Acceptance, screening, and transfer of cargo.

    Science.gov (United States)

    2010-10-01

    ... that cargo in accordance with this part, or parts 1544, 1546, or 1548 of this chapter. (d) Chain of custody. Each certified cargo screening facility must protect the cargo from unauthorized access from the...

  3. acute compartment syndrome of the thigh without associated fracture

    African Journals Online (AJOL)

    exercise and contact sport like rugby and soccer (7-11). Other cases were in association with arterial injury (4,. 5, 12). The diagnosis of acute compartment syndrome of the thigh requires a high index of suspicion as it is not a common complication of thigh injury (5). Like compartment syndrome elsewhere, thigh compartment.

  4. A simplified tether model for molecular motor transporting cargo

    International Nuclear Information System (INIS)

    Fang-Zhen, Li; Li-Chun, Jiang

    2010-01-01

    Molecular motors are proteins or protein complexes which function as transporting engines in biological cells. This paper models the tether between motor and its cargo as a symmetric linear potential. Different from Elston and Peskin's work for which performance of the system was discussed only in some limiting cases, this study produces analytic solutions of the problem for general cases by simplifying the transport system into two physical states, which makes it possible to discuss the dynamics of the motor–cargo system in detail. It turns out that the tether strength between motor and cargo should be greater than a threshold or the motor will fail to transport the cargo, which was not discussed by former researchers yet. Value of the threshold depends on the diffusion coefficients of cargo and motor and also on the strength of the Brownian ratchets dragging the system. The threshold approaches a finite constant when the strength of the ratchet tends to infinity. (general)

  5. Transporting "exceptional cargo" on the CERN sites

    CERN Document Server

    EN Department

    2012-01-01

    When the Transport Service is managing "exceptional cargo", the driver and the escort are often in charge of an operation involving equipment worth many hundred thousand francs. Equipment that may well be irreplaceable for a facility or an experiment.   The members of the Transport Service who carry out these tasks are very professional and are – needless to say – highly concentrated on the job. They count on your understanding and support in the traffic on site. Their convoys are – for good reasons – moving slowly. Kindly do not overtake, do not cut in in front of them and do not drive too closely. Respect the escort and do not position yourself between the truck and the escort vehicles. The EN department counts on your courtesy on the road.  

  6. Enteral Feeding in Abdominal Compartment Syndrome

    Directory of Open Access Journals (Sweden)

    Ye. V Grigoryev

    2009-01-01

    Full Text Available Objective: to substantiate the choice of a gastrointestinal tract (GIT function support regimen as a mode for correction of the abdominal compartment syndrome (ACS. Subjects and methods. Forty-three patients with different causes of inadequate GIT function of various origin and ACS (disseminated peritonitis (45%, pancreatitis (24%, and severe concomitant injury (31% were examined. Group 1 (control received complete parenteral nutritional feeding (n=23; APACHE II scores, 21±4; calculated probability of fatal outcome, 33.5%. In Group II (study, complete parenteral feeding in the first 24 hours after stabilization was supplemented with GIT function support with Pepsisorb (Nutricia in doses of 500, 1000, and 1500 ml on days 1, 2, and 3, respectively (n=20; APACHE II scores, 20±6; calculated probability of fatal outcome, 37.1%. During early enteral nutritional support, the SOFA score was significantly less than that in Group 1 on days 2—3; the oxygenation index significantly increased on day 3; the value of intra-abdominal hypertension decreased to the control values. The positive effect of the GIT function support regimen on regression of the multiple organ dysfunction syndrome (MODS was confirmed by the lowered levels of biological markers (von Willebrand factor (WF and endothelin-1 as markers of endothelial damage of MODS. Correlation analysis showed a direct correlation between the markers of endothelial damage and the SOFA scores (r=0.34; p=0.05 for WF and r=0.49;p=0.03 for endothelin. Conclusion. The GIT function support regimen via early enteral alimentation with Peptisorb, which was initiated in the first 24 hours after admission, is able to level off the manifestations of the early stages of the abdominal compartment syndrome, with the acceptable values of oxygen balance and water-electrolyte and osmotic homeostasis being achieved. Key words: abdominal compartment syndrome, nutritional support, biological markers, oxygenation index

  7. [Intraabdominal hypertension and abdominal compartment syndrome

    DEFF Research Database (Denmark)

    Sonne, M.; Hilligsø, Jens Georg

    2008-01-01

    Intraabdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are rare conditions with high mortality. IAH is an intraabdominal pressure (IAP) above 12 mmHg and ACS an IAP above 20 mmHg with evidence of organ dysfunction. IAP is measured indirectly via the bladder or stomach. Various...... medical and surgical conditions increase the intraabdominal volume. When the content exceeds the compliance of the abdominal wall, the IAP rises. Increased IAP affects the functioning of the brain, lungs, circulation, kidneys, and bowel. The treatment of ACS is a reduction of IAP Udgivelsesdato: 2008/2/11...

  8. Orbital compartment syndrome following aneurysm surgery.

    Science.gov (United States)

    Gauden, Andrew J; Hardy, Thomas; Mack, Heather G; Danesh-Meyer, Helen V; Kaye, Andrew H

    2012-07-01

    Orbital compartment syndrome (OCS) is a rare cause of blindness following intracranial surgery. We report a patient with OCS following intracranial cerebrovascular surgery precipitated by severe straining. OCS occurred due to a rapid increase in intraorbital pressure within the rigid confines of the orbit causing hypoperfusion of critical neural structures, which resulted in visual loss and a complete external ophthalmoplegia. Treatment involved urgent surgical soft tissue decompression of the orbit, corticosteroids and osmotic agents. It is important to consider OCS as a cause of blindness in the neurosurgical postoperative setting as without rapid treatment this condition has a very poor prognosis. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

  9. Gluteal Compartment Syndrome After Prolonged Immobilisation

    Directory of Open Access Journals (Sweden)

    H.L. Liu

    2009-04-01

    Full Text Available Muscles in the gluteal region are confined by distinct fascial attachments which can potentially result in compartment syndrome. A 74-year-old chronic drinker was admitted to the medical ward after being found drunk on the street. He noticed acute painful swelling of the right side of his buttock the following morning and recalled a slip and fall prior to his blackout. The whole right half of the buttock was tense with erythematous overlying skin. Examination revealed sciatic nerve palsy and myoglobinuria. Emergency fasciotomy and debridement were performed. Intra-operative pressure measurement confirmed a grossly elevated intra-compartmental pressure. Gluteal compartment syndrome is an extremely rare condition and has only been scantily documented previously in case reports. Early diagnosis is crucial but delay recognition is common from lack of knowledge of the condition and readily results in permanent sciatic nerve injury and acute renal shutdown from myoglobinuria. Awareness of the condition, early diagnosis and prompt exploration provide the only chance of avoiding these devastating consequences. Acute swelling diffusely affecting the whole or one side of the buttock, a history of trauma and prolonged local pressure impingement associated with pain out of proportion to the clinical signs should raise a suspicion of this rare condition.

  10. Technical and economic evaluation of advanced air cargo system concepts

    Science.gov (United States)

    Whitehead, A. H., Jr.

    1977-01-01

    The paper reviews NASA air cargo market studies, reports on NASA and NASA-sponsored studies of advanced freighter concepts, and identifies the opportunities for the application of advanced technology. The air cargo market is studied to evaluate the timing for, and the potential market response to, advanced technology aircraft. The degree of elasticity in future air freight markets is also being investigated, since the demand for a new aircraft is most favorable in a price-sensitive environment. Aircraft design studies are considered with attention to mission and design requirements, incorporation of advanced technologies in transport aircraft, new cargo aircraft concepts, advanced freighter evaluation, and civil-military design commonality.

  11. Air Cargo Transportation Route Choice Analysis

    Science.gov (United States)

    Obashi, Hiroshi; Kim, Tae-Seung; Oum, Tae Hoon

    2003-01-01

    Using a unique feature of air cargo transshipment data in the Northeast Asian region, this paper identifies the critical factors that determine the transshipment route choice. Taking advantage of the variations in the transport characteristics in each origin-destination airports pair, the paper uses a discrete choice model to describe the transshipping route choice decision made by an agent (i.e., freight forwarder, consolidator, and large shipper). The analysis incorporates two major factors, monetary cost (such as line-haul cost and landing fee) and time cost (i.e., aircraft turnaround time, including loading and unloading time, custom clearance time, and expected scheduled delay), along with other controls. The estimation method considers the presence of unobserved attributes, and corrects for resulting endogeneity by use of appropriate instrumental variables. Estimation results find that transshipment volumes are more sensitive to time cost, and that the reduction in aircraft turnaround time by 1 hour would be worth the increase in airport charges by more than $1000. Simulation exercises measures the impacts of alternative policy scenarios for a Korean airport, which has recently declared their intention to be a future regional hub in the Northeast Asian region. The results suggest that reducing aircraft turnaround time at the airport be an effective strategy, rather than subsidizing to reduce airport charges.

  12. Commercial Firm Training Practices versus Aerial Port Hazardous Cargo Frustration

    National Research Council Canada - National Science Library

    Maynard, Jill L

    2007-01-01

    .... This research investigates if commercial companies are a cause of the frustration problems. A case study methodology was used to investigate training practices of companies that had frustrated hazardous cargo at either Charleston or Dover Aerial Ports...

  13. Cargo/Weapons Elevator Land Based Engineering Site

    Data.gov (United States)

    Federal Laboratory Consortium — The Cargo and Weapons Facility consists of a suite of full scale and component test facilities contiguously located in building 77H. The site was constructed in 1987...

  14. Aggregating Secondary Source Data for Air Cargo Prescreening, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to improve the effectiveness of air cargo prescreening by enabling background knowledge about companies and products to be used for threat assessment. The...

  15. Air cargo in the Mid-America Freight Coalition region.

    Science.gov (United States)

    2012-08-01

    This report contains a contextual review of air cargo transportation in the 10-state Mid-America Freight Coalition (MAFC) region including the industrys recent history, security implications, and integration within the greater MAFC economy. The re...

  16. 46 CFR 153.436 - Heat transfer fluids: compatibility with cargo.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Heat transfer fluids: compatibility with cargo. 153.436... Equipment Cargo Temperature Control Systems § 153.436 Heat transfer fluids: compatibility with cargo. A heat transfer fluid separated from the cargo by only one wall (for example, the heat transfer fluid in a coil...

  17. 46 CFR 32.50-30 - Cargo hose-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo hose-TB/ALL. 32.50-30 Section 32.50-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Pumps, Piping, and Hose for Cargo Handling § 32.50-30 Cargo hose—TB/ALL. Cargo hose carried on...

  18. 46 CFR 30.10-6 - Cargo handling room-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo handling room-TB/ALL. 30.10-6 Section 30.10-6 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-6 Cargo handling room—TB/ALL. The term cargo handling room means any enclosed space where cargo is pumped...

  19. 19 CFR 122.117 - Requirements for transit air cargo transport.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Requirements for transit air cargo transport. 122... Requirements for transit air cargo transport. (a) Transportation—(1) Port to port. Transit air cargo may be... cargo, a receipt shall be given. The receipt shall be made by the airline responsible for transport or...

  20. 14 CFR 296.6 - Public disclosure of cargo liability limits and insurance.

    Science.gov (United States)

    2010-01-01

    ....6 Public disclosure of cargo liability limits and insurance. Every indirect cargo air carrier shall... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Public disclosure of cargo liability limits... cargo liability accident insurance, and of the limits on the extent of its liability, if any. The notice...

  1. 46 CFR 153.934 - Entry into spaces containing cargo vapor.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Entry into spaces containing cargo vapor. 153.934... General Vessel Safety § 153.934 Entry into spaces containing cargo vapor. (a) No person may enter a cargo... enclosed space in the cargo area, the master shall make sure that: (1) The space is free of toxic vapors...

  2. 46 CFR 154.405 - Design vapor pressure (Po) of a cargo tank.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Design vapor pressure (Po) of a cargo tank. 154.405... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction and Equipment Cargo Containment Systems § 154.405 Design vapor pressure (Po) of a cargo tank. (a) The design...

  3. 46 CFR 98.25-10 - Design and construction of cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Design and construction of cargo tanks. 98.25-10 Section... Anhydrous Ammonia in Bulk § 98.25-10 Design and construction of cargo tanks. (a) The cargo tanks shall meet... Engineering) of this chapter. (b) Unlagged cargo tanks subject to atmospheric temperatures shall be designed...

  4. 46 CFR 154.406 - Design loads for cargo tanks and fixtures: General.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Design loads for cargo tanks and fixtures: General. 154..., Construction and Equipment Cargo Containment Systems § 154.406 Design loads for cargo tanks and fixtures: General. (a) Calculations must show that a cargo tank and its fixtures are designed for the following...

  5. 49 CFR 173.315 - Compressed gases in cargo tanks and portable tanks.

    Science.gov (United States)

    2010-10-01

    ... qualified assembly, repair, maintenance, or requalification facility. The cargo tank need not be cleaned and... the cargo tank. If the vehicle engine is supplied fuel from the cargo tank, enough fuel in excess of... 49 Transportation 2 2010-10-01 2010-10-01 false Compressed gases in cargo tanks and portable tanks...

  6. Modeling malware propagation using a carrier compartment

    Science.gov (United States)

    Hernández Guillén, J. D.; Martín del Rey, A.

    2018-03-01

    The great majority of mathematical models proposed to simulate malware spreading are based on systems of ordinary differential equations. These are compartmental models where the devices are classified according to some types: susceptible, exposed, infectious, recovered, etc. As far as we know, there is not any model considering the special class of carrier devices. This type is constituted by the devices whose operative systems is not targeted by the malware (for example, iOS devices for Android malware). In this work a novel mathematical model considering this new compartment is considered. Its qualitative study is presented and a detailed analysis of the efficient control measures is shown by studying the basic reproductive number.

  7. The upper hand on compartment syndrome.

    LENUS (Irish Health Repository)

    Dolan, Roisin T

    2012-11-01

    Metacarpal fractures are common injuries, accounting for approximately 30% to 40% of all hand fractures and with a lifetime incidence of 2.5%. Traditionally regarded as an innocuous injury, metacarpal fractures tend to be associated with successful outcomes after closed reduction and immobilization. Hand compartment syndrome (HCS) is a rare clinical entity with potential devastating consequences in terms of loss of function and quality-of-life outcomes. We discuss the case of a 44-year-old woman presenting with multiple closed metacarpal fractures as a result of low-energy trauma, complicated by acute HCS. We review the presentation, clinical assessment, and optimal surgical management of acute HCS with reference to international literature.

  8. Fungal community assemblage of different soil compartments in mangrove ecosystem

    OpenAIRE

    Loganathachetti, Dinesh Sanka; Poosakkannu, Anbu; Muthuraman, Sundararaman

    2017-01-01

    The fungal communities of different soil compartments in mangrove ecosystem are poorly studied. We sequenced the internal transcribed spacer (ITS) regions to characterize the fungal communities in Avicennia marina root-associated soils (rhizosphere and pneumatophore) and bulk soil compartments. The rhizosphere but not pneumatophore soil compartment had significantly lower fungal species richness than bulk soil. However, bulk soil fungal diversity (Shannon diversity index) was significantly hi...

  9. Network model of cargo processing in containers in the sea ports of Ukraine

    OpenAIRE

    Светлана Петровна Онищенко; Марина Сергеевна Вильшанюк

    2016-01-01

    It is identified the number of operations on cargo processing in containers in the sea ports of Ukraine and build a logical model of the relationship for the members of cargo service. It is developed a network model of cargo processing in containers in the sea ports of Ukraine as a tool for coordination of operations during processing. The used method allows creating an effective cargo processing plan and identifying and reducing the period of container location with cargo in the port

  10. Spectroscopic neutron radiography for a cargo scanning system

    Energy Technology Data Exchange (ETDEWEB)

    Rahon, Jill [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (United States); Danagoulian, Areg, E-mail: aregjan@mit.edu [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (United States); MacDonald, Thomas D. [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (United States); Hartwig, Zachary S. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (United States); Lanza, Richard C. [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (United States)

    2016-06-01

    Detection of cross-border smuggling of illicit materials and contraband is a challenge that requires rapid, low-dose, and efficient radiographic technology. The work we describe here is derived from a technique which uses monoenergetic gamma rays from low energy nuclear reactions, such as {sup 11}B(d,nγ){sup 12}C, to perform radiographic analysis of shipping containers. Transmission ratios of multiple monoenergetic gamma lines resulting from several gamma producing nuclear reactions can be employed to detect materials of high atomic number (Z), the details of which will be described in a separate paper. Inherent in this particular nuclear reaction is the production of fast neutrons which could enable neutron radiography and further characterization of the effective-Z of the cargo, especially within the range of lower Z. Previous research efforts focused on the use of total neutron counts in combination with X-ray radiography to characterize the hydrogenous content of the cargo. We present a technique of performing transmitted neutron spectral analysis to reconstruct the effective Z and potentially the density of the cargo. This is made possible by the large differences in the energy dependence of neutron scattering cross-sections between hydrogenous materials and those of higher Z. These dependencies result in harder transmission spectra for hydrogenous cargoes than those of non-hydrogenous cargoes. Such observed differences can then be used to classify the cargo based on its hydrogenous content. The studies presented in this paper demonstrate that such techniques are feasible and can provide a contribution to cargo security, especially when used in concert with gamma radiography.

  11. Distal biceps brachii tendon rupture resulting in acute compartment syndrome.

    Science.gov (United States)

    Grandizio, Louis C; Suk, Michael; Feltham, Glen T

    2013-11-01

    Distal biceps brachii tendon rupture is an uncommon injury. Compartment syndrome of the upper arm is rarely described in the literature. The diagnosis of upper arm compartment syndrome requires a high index of suspicion, and emergent surgical treatment with fasciotomy in the acute setting is necessary to avoid devastating neurovascular complications. This article reports a case of acute compartment syndrome of the anterior compartment of the upper arm after a complete rupture of the distal biceps brachii tendon. A healthy 45-year-old man presented with increasing arm pain; paresthesia in the lateral antebrachial cutaneous nerve distribution; and a tense, swollen anterior compartment of his upper arm. Side port catheter absolute pressure measurement was 83 mm Hg with a diastolic blood pressure of 92 mm Hg. The patient underwent an emergent fasciotomy and was found to have a complete rupture of his distal biceps brachii tendon. He subsequently underwent distal biceps tendon repair and delayed primary closure of his incision. Postoperatively, his paresthesia improved and he has no neurological deficit. There is a paucity of case reports describing compartment syndrome after rupture of either the proximal or distal end of the biceps brachii tendon, and none of the reports describe compartment syndrome of the upper arm after rupture of the distal biceps tendon. This article highlights an unusual complication of an uncommon injury and reviews diagnostic and treatment principles for the management of acute compartment syndrome of the upper arm. Copyright 2013, SLACK Incorporated.

  12. 46 CFR 169.625 - Compartments containing diesel machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Compartments containing diesel machinery. 169.625 Section 169.625 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Machinery and Electrical Ventilation § 169.625 Compartments containing diesel machinery. (a) Spaces containing machinery must be...

  13. 9 CFR 354.241 - Cleaning of rooms and compartments.

    Science.gov (United States)

    2010-01-01

    ... light fixtures in the official plant shall be kept clean. (c) All docks and rooms shall be kept clean... compartments. Rooms, compartments, or other parts of the official plant shall be kept clean and in sanitary... rooms should be kept clean at all times. (e) Floors in live rabbit holding rooms shall be cleaned with...

  14. Fungal community assemblage of different soil compartments in mangrove ecosystem.

    Science.gov (United States)

    Sanka Loganathachetti, Dinesh; Poosakkannu, Anbu; Muthuraman, Sundararaman

    2017-08-17

    The fungal communities of different soil compartments in mangrove ecosystem are poorly studied. We sequenced the internal transcribed spacer (ITS) regions to characterize the fungal communities in Avicennia marina root-associated soils (rhizosphere and pneumatophore) and bulk soil compartments. The rhizosphere but not pneumatophore soil compartment had significantly lower fungal species richness than bulk soil. However, bulk soil fungal diversity (Shannon diversity index) was significantly higher than both pneumatophore and rhizosphere soil compartments. The different soil compartments significantly affected the fungal community composition. Pairwise sample analyses showed that bulk soil microbial community composition significantly different from rhizosphere and pneumatophore soil compartments. There was, however no significant difference observed between rhizosphere and pneumatophore soil fungal community composition and they shared relatively more OTUs between them. Further, there was a significant correlation observed between fungal community compositional changes and carbon or nitrogen availability of different soil compartments. These results suggest that few characteristics such as fungal richness and taxa abundance of rhizosphere and pneumatophore soil compartments were significantly different in mangrove ecosystem.

  15. Mathematical models for drug diffusion through the compartments of ...

    African Journals Online (AJOL)

    The Laplace transform and eigenvalue methods were used to obtain the solution of the ordinary differential equations concerning the rate of change of concentration in different compartments viz. blood and tissue medium. The drug concentration in the different compartments has been computed using numerical parameters ...

  16. Abdominal Compartment Syndrome Secondary to Chronic Constipation

    Directory of Open Access Journals (Sweden)

    Helene Flageole

    2011-01-01

    Full Text Available Abdominal compartment syndrome (ACS is defined as an elevated intraabdominal pressure with evidence of organ dysfunction. The majority of published reports of ACS are in neonates with abdominal wall defects and in adults following trauma or burns, but it is poorly described in children. We describe the unusual presentation of an 11-year-old boy with a long history of chronic constipation who developed acute ACS requiring resuscitative measures and emergent disimpaction. He presented with a 2-week history of increasing abdominal pain, nausea, diminished appetite and longstanding encopresis. On exam, he was emaciated with a massively distended abdomen with a palpable fecaloma. Abdominal XR confirmed these findings. Within 24 hours of presentation, he became tachycardic and oliguric with orthostatic hypotension. Following two enemas, he acutely deteriorated with severe hypotension, marked tachycardia, acute respiratory distress, and a declining mental status. Endotracheal intubation, fluid boluses, and vasopressors were commenced, followed by emergent surgical fecal disimpaction. This resulted in rapid improvement in vital signs. He has been thoroughly investigated and no other condition apart from functional constipation has been identified. Although ACS secondary to constipation is extremely unusual, this case illustrates the need to actively treat constipation and what can happen if it is not.

  17. Compartment in vertical flow reactor for ferruginous mine water

    Science.gov (United States)

    Hur, Won; Cheong, Young-Wook; Yim, Gil-Jae; Ji, Sang-Woo; Hong, Ji-Hye

    2014-05-01

    Mine effluents contain varying concentrations of ferrous ion along with other metal ions. Fe(II) that quickly oxidizes to form precipitates in the presence of oxygen under net alkaline or neutral conditions. Thus, passive treatment methods are designed for the mine water to reside in an open containment area so as to allow simultaneous oxidation and precipitation of Fe(II), such as in a lagoon or an oxidation pond. A vertical flow reactor (VFR) was also suggested to remediate ferruginous mine drainage passing down through an accreting bed of ochre. However, VFR has a limited operation time until the system begins to overflow. It was also demonstrated that two-compartment VFR has a longer operation time than single compartment VFR of same size. In this study, a mathematical model was developed as a part of efforts to explore the operation of VFR, showing dynamic changes in head differences, ochre depth and Fe(II)/Fe(III) concentration in the effluent flow. The analysis shows that Fe(II) oxidation and ochre formation should be balanced with permeability of ochre bed to maximize VFR operation time and minimize residual Fe(II) in the effluent. The model demonstrates that two compartment VFR can have a longer operation time than a single-compartment VFR and that an optimum compartment ratio exists that maximize VFR operation time. Accelerated Fe(II) oxidation significantly affects the optimum ratio of compartment area and reduced residual Fe(II) in the effluent. VFR operation time can be significantly prolonged by increasing the rate of ochre formation not by accelerated Fe(II) oxidation. Taken together, ochre forms largely in the first compartment while overflowed mine water with reduced iron contents is efficiently filtered in the second compartment. These results provide us a better understanding of VFR operation and optimum design criteria for maximum operation time in a two-compartment VFR. Rapid ochre accretion in the first compartment maintains constant hydraulic

  18. Computation of thermal comfort inside a passenger car compartment

    International Nuclear Information System (INIS)

    Mezrhab, A.; Bouzidi, M.

    2006-01-01

    This paper describes a numerical model to study the behaviour of thermal comfort inside the passenger car compartment according to climatic conditions and materials that compose the vehicle. The specifically developed numerical model is based on the nodal method and the finite difference method. Its specificities are: (i) the transient mode, (ii) the taking into account of the combined convection, conduction and radiation heat transfer, (iii) the coupling of two spectral bands (short-wave and long-wave radiation) and two solar fluxes (beam and diffuse). The compartment is subdivided in several solid nodes (materials constituting the compartment) and fluid nodes (volumes of air inside the compartment). The establishment of the heat balance for each node gives the evolution of its temperature. Effects of solar radiation, types of glazing, car colour and radiative properties of materials constituting the compartment are investigated

  19. Optimisation of key performance measures in air cargo demand management

    Directory of Open Access Journals (Sweden)

    Alexander May

    2014-03-01

    Full Text Available This article sought to facilitate the optimisation of key performance measures utilised for demand management in air cargo operations. The focus was on the Revenue Management team at Virgin Atlantic Cargo and a fuzzy group decision-making method was used. Utilising intelligent fuzzy multi-criteria methods, the authors generated a ranking order of ten key outcome-based performance indicators for Virgin Atlantic air cargo Revenue Management. The result of this industry-driven study showed that for Air Cargo Revenue Management, ‘Network Optimisation’ represents a critical outcome-based performance indicator. This collaborative study contributes to existing logistics management literature, especially in the area of Revenue Management, and it seeks to enhance Revenue Management practice. It also provides a platform for Air Cargo operators seeking to improve reliability values for their key performance indicators as a means of enhancing operational monitoring power.

  20. A human cadaver fascial compartment pressure measurement model.

    Science.gov (United States)

    Messina, Frank C; Cooper, Dylan; Huffman, Gretchen; Bartkus, Edward; Wilbur, Lee

    2013-10-01

    Fresh human cadavers provide an effective model for procedural training. Currently, there are no realistic models to teach fascial compartment pressure measurement. We created a human cadaver fascial compartment pressure measurement model and studied its feasibility with a pre-post design. Three faculty members, following instructions from a common procedure textbook, used a standard handheld intra-compartment pressure monitor (Stryker(®), Kalamazoo, MI) to measure baseline pressures ("unembalmed") in the anterior, lateral, deep posterior, and superficial posterior compartments of the lower legs of a fresh human cadaver. The right femoral artery was then identified by superficial dissection, cannulated distally towards the lower leg, and connected to a standard embalming machine. After a 5-min infusion, the same three faculty members re-measured pressures ("embalmed") of the same compartments on the cannulated right leg. Unembalmed and embalmed readings for each compartment, and baseline readings for each leg, were compared using a two-sided paired t-test. The mean baseline compartment pressures did not differ between the right and left legs. Using the embalming machine, compartment pressure readings increased significantly over baseline for three of four fascial compartments; all in mm Hg (±SD): anterior from 40 (±9) to 143 (±44) (p = 0.08); lateral from 22 (±2.5) to 160 (±4.3) (p measurable fascial compartment pressure measurement model in a fresh human cadaver using a standard embalming machine. Set-up is minimal and the model can be incorporated into teaching curricula. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. 46 CFR 151.05-2 - Compliance with requirements for tank barges carrying benzene and benzene containing cargoes, or...

    Science.gov (United States)

    2010-10-01

    ... benzene and benzene containing cargoes, or butyl acrylate cargoes. 151.05-2 Section 151.05-2 Shipping... Compliance with requirements for tank barges carrying benzene and benzene containing cargoes, or butyl acrylate cargoes. A tank barge certificated to carry benzene and benzene containing cargoes or butyl...

  2. Reducing Mission Logistics with Multipurpose Cargo Transfer Bags

    Science.gov (United States)

    Baccus, Shelley; Broyan, James Lee, Jr.; Borrego, Melissa

    2016-01-01

    The Logistics Reduction (LR) project within Advanced Exploration Systems (AES) is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) have been designed such that they can serve the same purpose as a Cargo Transfer Bag (CTB), the common logistics carrying bag for the International Space Station (ISS). After use as a cargo carrier, a regular CTB becomes trash, whereas the MCTB can be unfolded into a flat panel for reuse. Concepts and potential benefits for various MCTB applications will be discussed including partitions, crew quarters, solar radiation storm shelters, acoustic blankets, and forward osmosis water processing. Acoustic MCTBs are currently in use on ISS to reduce the noise generated by the T2 treadmill, which reaches the hazard limit at high speeds. The development of the AMCTB included identification of keep-out zones, acoustic properties, deployment considerations, and structural testing. Features developed for these considerations are applicable to MCTBs for all crew outfitting applications.

  3. Multipurpose Cargo Transfer Bags fro Reducing Exploration Mission Logistics

    Science.gov (United States)

    Baccus, Shelley; Broyan, James Lee, Jr.; Borrego, Melissa

    2016-01-01

    The Logistics Reduction (LR) project within the Advanced Exploration Systems (AES) division is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) have been designed such that they can serve the same purpose as a Cargo Transfer Bag (CTB), the common logistics carrying bag for the International Space Station (ISS). After use as a cargo carrier, a regular CTB becomes trash, whereas the MCTB can be unfolded into a flat panel for reuse. Concepts and potential benefits for various MCTB applications will be discussed including partitions, crew quarters, solar radiation storm shelters, acoustic blankets, and forward osmosis water processing. Acoustic MCTBs are currently in use on ISS to reduce the noise generated by the T2 treadmill, which reaches the hazard limit at high speeds. The development of the AMCTB included identification of keep out zones, acoustic properties, deployment considerations, and structural testing. Features developed for these considerations are applicable to MCTBs for all crew outfitting applications.

  4. Shared Value Potential of Transporting Cargo via Hyperloop

    Directory of Open Access Journals (Sweden)

    Max Werner

    2016-08-01

    Full Text Available This research estimates the shared value created by constructing a hypothetical Hyperloop to transport cargo along 300 km in Northern Germany. Following Porter-Kramer (2011, we identified and evaluated eight factors that create shared value: travel speed, operating costs, safety, noise pollution, air pollution, climate effect/carbon footprint, separation effect/ property efficiency, and maintenance. Using official data compiled by several German institutes and organizations, we conducted comparative analysis to quantify and compare the abovementioned factors for Hyperloop and over-the-road cargo transport in Germany. Then, we monetized the individual and collective benefits of the shared value created by Hyperloop replacing a significant share of cargo transported by truck. Our findings indicate that the hypothetical Hyperloop project in Northern Germany would create €660 to €900 million of shared value annually. Our research method establishes a framework for assessing future transportation projects like Hyperloop, and our findings can be generalized to industrialized nations beyond Germany.

  5. Trace elements distribution in environmental compartments

    Energy Technology Data Exchange (ETDEWEB)

    Queiroz, Juliana C. de; Peres, Sueli da Silva; Godoy, Maria Luiza D.P., E-mail: suelip@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2017-11-01

    Trace elements term defines the presence of low concentrations metals at environment. Some of them are considered biologically essential, as Co, Cu and Mn. Others can cause detriment to environment and human health, as Pb, Cd, Hg, As, Ti and U. A large number of them have radioactive isotopes, implying the evaluation of risks for human health should be done considering the precepts of environmental radiological protection. The ecosystem pollution with trace elements generates changes at the geochemistry cycle of these elements and in environmental quality. Soils have single characteristics when compared with another components of biosphere (air, water and biota), cause they introduce themselves not only as a drain towards contaminants, but also as natural buffer that control the transport of chemical elements and other substances for atmosphere, hydrosphere and biota. The main purpose of environmental monitoring program is to evaluate the levels of contaminants in the various compartments of the environment: natural or anthropogenic, and to assess the contribution of a potential contaminant source on the environment. Elemental Composition for the collected samples was determined by inductively coupled plasma mass spectroscopy. The main objective of this work was to evaluate the map baseline of concentration of interest trace elements in environmental samples of water, sediment and soil from Environmental Monitoring Program of Instituto de Radioprotecao e Dosimetria (IRD). The samples were analyzed using an inductively coupled plasma mass spectrometer (ICP-MS) at IRD. >From the knowledge of trace elements concentrations, could be evaluated the environmental quality parameters at the studied ecosystems. The data allowed evaluating some relevant aspects of the study of trace elements in soil and aquatic systems, with emphasis at the distribution, concentration and identification of main anthropic sources of contamination at environment. (author)

  6. Trace elements distribution in environmental compartments

    International Nuclear Information System (INIS)

    Queiroz, Juliana C. de; Peres, Sueli da Silva; Godoy, Maria Luiza D.P.

    2017-01-01

    Trace elements term defines the presence of low concentrations metals at environment. Some of them are considered biologically essential, as Co, Cu and Mn. Others can cause detriment to environment and human health, as Pb, Cd, Hg, As, Ti and U. A large number of them have radioactive isotopes, implying the evaluation of risks for human health should be done considering the precepts of environmental radiological protection. The ecosystem pollution with trace elements generates changes at the geochemistry cycle of these elements and in environmental quality. Soils have single characteristics when compared with another components of biosphere (air, water and biota), cause they introduce themselves not only as a drain towards contaminants, but also as natural buffer that control the transport of chemical elements and other substances for atmosphere, hydrosphere and biota. The main purpose of environmental monitoring program is to evaluate the levels of contaminants in the various compartments of the environment: natural or anthropogenic, and to assess the contribution of a potential contaminant source on the environment. Elemental Composition for the collected samples was determined by inductively coupled plasma mass spectroscopy. The main objective of this work was to evaluate the map baseline of concentration of interest trace elements in environmental samples of water, sediment and soil from Environmental Monitoring Program of Instituto de Radioprotecao e Dosimetria (IRD). The samples were analyzed using an inductively coupled plasma mass spectrometer (ICP-MS) at IRD. >From the knowledge of trace elements concentrations, could be evaluated the environmental quality parameters at the studied ecosystems. The data allowed evaluating some relevant aspects of the study of trace elements in soil and aquatic systems, with emphasis at the distribution, concentration and identification of main anthropic sources of contamination at environment. (author)

  7. A matheuristic for the Cargo Mix Problem with Block Stowage

    DEFF Research Database (Denmark)

    Christensen, Jonas Mark; Pacino, Dario

    2017-01-01

    The cargo-mix problem aims at selecting the amount of containers of a given type to load on a vessel. In this article we present an extended definition that includes the analysis of a circular route with draft restrictions, limitations on expected cargo and the use of a block stowage strategy....... A compact formulation of the problem based on the state-of-the-art heuristic decomposition is shown not to be able to solve the extended problem, thus a matheuristic approach is presented that can achieve high quality results in a matter of seconds....

  8. Shift designs for freight handling personnel at air cargo terminals

    DEFF Research Database (Denmark)

    Rong, Aiying; Grunow, Martin

    2009-01-01

    This paper presents an integrated mixed integer linear programming (MILP) model for determining manpower requirements and related personnel shift designs for the build-up and break-down of the unit load devices (ULDs) at the air cargo terminal to minimize manpower costs. To utilize the manpower...... resources efficiently, we implement a new mechanism for demand leveling. In addition, we consider the qualification hierarchy between build-up and break-down workers. A case study based on the real-life data shows that the model is useful for manpower planning at air cargo terminals and the integrated...

  9. SHIP AND CARGO MORTGAGE, TWO DIFFERENT LEGAL VIEWPOINTS

    Directory of Open Access Journals (Sweden)

    Mohammad Abouata

    2015-05-01

    Full Text Available Although the subject-matter of cargo and ship mortgage are similar (providing financial security for creditors,the regulations of these contracts, differ from each other essentially with regard to the conditionality of taking possession in concluding the contract, the possibility of endorsement and cession in mortgage document, the creditor s kind of real right ,the preference of prior or latter creditor in vindication of right and the effect of mortgage loss on the contract and the possibility of recovery of claim. Moreover the cargo mortgage regulations are, in some regards and aspects, contrary to general legal rules and hence subject to criticism.

  10. Stochastic Turing Patterns: Analysis of Compartment-Based Approaches

    KAUST Repository

    Cao, Yang

    2014-11-25

    © 2014, Society for Mathematical Biology. Turing patterns can be observed in reaction-diffusion systems where chemical species have different diffusion constants. In recent years, several studies investigated the effects of noise on Turing patterns and showed that the parameter regimes, for which stochastic Turing patterns are observed, can be larger than the parameter regimes predicted by deterministic models, which are written in terms of partial differential equations (PDEs) for species concentrations. A common stochastic reaction-diffusion approach is written in terms of compartment-based (lattice-based) models, where the domain of interest is divided into artificial compartments and the number of molecules in each compartment is simulated. In this paper, the dependence of stochastic Turing patterns on the compartment size is investigated. It has previously been shown (for relatively simpler systems) that a modeler should not choose compartment sizes which are too small or too large, and that the optimal compartment size depends on the diffusion constant. Taking these results into account, we propose and study a compartment-based model of Turing patterns where each chemical species is described using a different set of compartments. It is shown that the parameter regions where spatial patterns form are different from the regions obtained by classical deterministic PDE-based models, but they are also different from the results obtained for the stochastic reaction-diffusion models which use a single set of compartments for all chemical species. In particular, it is argued that some previously reported results on the effect of noise on Turing patterns in biological systems need to be reinterpreted.

  11. Extracellular Tau Oligomers Induce Invasion of Endogenous Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction

    Science.gov (United States)

    Swanson, Eric; Breckenridge, Leigham; McMahon, Lloyd; Som, Sreemoyee; McConnell, Ian; Bloom, George S.

    2017-01-01

    Aggregates composed of the microtubule associated protein, tau, are a hallmark of Alzheimer’s disease and non-Alzheimer’s tauopathies. Extracellular tau can induce the accumulation and aggregation of intracellular tau, and tau pathology can be transmitted along neural networks over time. There are six splice variants of central nervous system tau, and various oligomeric and fibrillar forms are associated with neurodegeneration in vivo. The particular extracellular forms of tau capable of transferring tau pathology from neuron to neuron remain ill defined, however, as do the consequences of intracellular tau aggregation on neuronal physiology. The present study was undertaken to compare the effects of extracellular tau monomers, oligomers, and filaments comprising various tau isoforms on the behavior of cultured neurons. We found that 2N4R or 2N3R tau oligomers provoked aggregation of endogenous intracellular tau much more effectively than monomers or fibrils, or of oligomers made from other tau isoforms, and that a mixture of all six isoforms most potently provoked intracellular tau accumulation. These effects were associated with invasion of tau into the somatodendritic compartment. Finally, we observed that 2N4R oligomers perturbed fast axonal transport of membranous organelles along microtubules. Intracellular tau accumulation was often accompanied by increases in the run length, run time and instantaneous velocity of membranous cargo. This work indicates that extracellular tau oligomers can disrupt normal neuronal homeostasis by triggering axonal tau accumulation and loss of the polarized distribution of tau, and by impairing fast axonal transport. PMID:28482642

  12. 78 FR 50134 - Altus Pharmaceuticals, Inc., Blackhawk Capital Group BDC, Inc., Cargo Connection Logistics...

    Science.gov (United States)

    2013-08-16

    ... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] Altus Pharmaceuticals, Inc., Blackhawk Capital Group BDC, Inc., Cargo Connection Logistics Holding, Inc., Diapulse Corporation of America, Globus... lack of current and accurate information concerning the securities of Cargo Connection Logistics...

  13. 46 CFR 153.297 - Emergency actuators at the point of cargo control.

    Science.gov (United States)

    2010-10-01

    ... DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Piping Systems and Cargo Handling Equipment § 153.297 Emergency actuators at the point... Handling Space Ventilation ...

  14. 49 CFR 178.348 - Specification DOT 412; cargo tank motor vehicle.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification DOT 412; cargo tank motor vehicle... SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.348 Specification DOT 412; cargo tank motor vehicle. ...

  15. 49 CFR 178.347 - Specification DOT 407; cargo tank motor vehicle.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification DOT 407; cargo tank motor vehicle... SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.347 Specification DOT 407; cargo tank motor vehicle. ...

  16. 49 CFR 178.346 - Specification DOT 406; cargo tank motor vehicle.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification DOT 406; cargo tank motor vehicle... SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.346 Specification DOT 406; cargo tank motor vehicle. ...

  17. 48 CFR 752.228-9 - Cargo insurance.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Cargo insurance. 752.228-9... insurance. As prescribed in 728.313(a), the following preface is to be used preceding the text of the clause at FAR 52.228-9: Preface: To the extent that marine insurance is necessary or appropriate under this...

  18. 19 CFR 4.41 - Cargo of wrecked vessel.

    Science.gov (United States)

    2010-04-01

    ...) Any cargo landed from a vessel wrecked in the waters of the United States or on the high seas shall be... the salvors of merchandise saved from a wreck at sea or on or along a coast of the United States may... laden with merchandise, in whole or in part subject to duty, has been sunk in any river, harbor, bay, or...

  19. 33 CFR 401.69 - Hazardous cargo vessels.

    Science.gov (United States)

    2010-07-01

    ... the following cases: (a) A tanker carrying fuel oil, gasoline, crude oil or other flammable liquids in bulk, having a flashpoint below 61 °C, including a tanker that is not gas free where its previous cargo had a flashpoint below 61 °C; (b) A tanker carrying compressed liquefied gases, bulk acids or...

  20. Screening Cargo Containers to Remove a Terrorist Threat

    International Nuclear Information System (INIS)

    Hazi, A

    2005-01-01

    Each year some 48 million cargo containers move between the world's ports. More than 6 million of these enter the U.S., but only about 2 percent are opened and inspected when they arrive at U.S. seaports. The West Coast ports of Los Angeles-Long Beach, Oakland, and Seattle alone process 11,000 containers per day, or about 8 containers per minute. Because of this high traffic volume, U.S. seaports are especially vulnerable to a terrorist attack. Illicit radioactive materials could be hidden in any one of the cargo-filled containers that arrive at U.S. ports. Yet, searching every shipment would be bring legitimate commercial activities to a halt. Improving security at U.S. ports is thus one of the nation's most difficult technical and practical challenges because the systems developed for screening cargo must operate in concert with ongoing seaport activities. Working at this intersection of commerce and national security, Lawrence Livermore researchers are applying their expertise in radiation science and detection to develop improved technologies for detecting hidden radioactive materials. One new technology being designed and tested at the Laboratory is a neutron interrogation system for cargo containers. This system will quickly screen incoming shipments to ensure that nuclear materials such as plutonium and highly enriched uranium (HEU) are not smuggled into the U.S

  1. Study on Alternative Cargo Launch Options from the Lunar Surface

    Energy Technology Data Exchange (ETDEWEB)

    Cheryl A. Blomberg; Zamir A. Zulkefli; Spencer W. Rich; Steven D. Howe

    2013-07-01

    In the future, there will be a need for constant cargo launches from Earth to Mars in order to build, and then sustain, a Martian base. Currently, chemical rockets are used for space launches. These are expensive and heavy due to the amount of necessary propellant. Nuclear thermal rockets (NTRs) are the next step in rocket design. Another alternative is to create a launcher on the lunar surface that uses magnetic levitation to launch cargo to Mars in order to minimize the amount of necessary propellant per mission. This paper investigates using nuclear power for six different cargo launching alternatives, as well as the orbital mechanics involved in launching cargo to a Martian base from the moon. Each alternative is compared to the other alternative launchers, as well as compared to using an NTR instead. This comparison is done on the basis of mass that must be shipped from Earth, the amount of necessary propellant, and the number of equivalent NTR launches. Of the options, a lunar coil launcher had a ship mass that is 12.7% less than the next best option and 17 NTR equivalent launches, making it the best of the presented six options.

  2. 19 CFR 122.48 - Air cargo manifest.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Air cargo manifest. 122.48 Section 122.48 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members...

  3. Investigating Block-Copolymer Micelle Dynamics for Tunable Cargo Delivery

    Science.gov (United States)

    Li, Xiuli; Kidd, Bryce; Cooksey, Tyler; Robertson, Megan; Madsen, Louis

    Block-copolymer micelles (BCPMs) can carry molecular cargo in a nanoscopic package that is tunable using polymer structure in combination with cargo properties, as well as with external stimuli such as temperature or pH. For example, BCPMs can be used in targeted anticancer drug delivery due to their biocompatibility, in vivo degradability and prolonged circulation time. We are using NMR spectroscopy and diffusometry as well as SANS to investigate BCPMs. Here we study a diblock poly(ethylene oxide)-b-(caprolactone) (PEO-PCL) that forms spherical micelles at 1% (w/v) in the mixed solvent D2O/THF-d8. We quantify the populations and diffusion coefficients of coexisting micelles and free unimers over a range of temperatures and solvent compositions. We use temperature as a stimulus to enhance unimer exchange and hence trigger cargo release, in some cases at a few degrees above body temperature. We present evidence for dominance of the insertion-expulsion mechanism of unimer exchange in these systems, and we map phase diagrams versus temperature and solvent composition. This study sheds light on how intermolecular interactions fundamentally affect cargo release, unimer exchange, and overall micelle tunability.

  4. Phototriggered cargo release from virus-like assemblies

    NARCIS (Netherlands)

    Brasch, M.; Voets, I.K.; Koay, M.S.T.; Cornelissen, Jeroen Johannes Lambertus Maria

    2013-01-01

    There has been tremendous progress towards the development of responsive polymers that are programmed to respond to an external stimulus such as light, pH and temperature. The unique combination of molecular packaging followed by slow, controlled release of molecular cargo is of particular

  5. Hepatitis Virus Capsid Polymorph Stability Depends on Encapsulated Cargo Size

    NARCIS (Netherlands)

    He, L.; Porterfield, Z.; van der Schoot, P. P. A. M.|info:eu-repo/dai/nl/102140618; Zlotnick, A.; Dragnea, B.

    2013-01-01

    Protein cages providing a controlled environment to encapsulated cargo are a ubiquitous presence in any biological system. Well-known examples are capsids, the regular protein shells of viruses, which protect and deliver the viral genome. Since some virus capsids can be loaded with nongenomic

  6. A consolidation model for cargo-driven intermodal transportation

    NARCIS (Netherlands)

    Behdani, B.; Zuidwijk, R.A.

    2014-01-01

    Accessibility of main sea ports by road has become increasingly difficult due to rapid growth in container throughput. To deal with this challenge, new ways for handling containers and distribution of cargo flows are needed to define and implement. One possibility is going beyond container

  7. Mars Hybrid Propulsion System Trajectory Analysis. Part II; Cargo Missions

    Science.gov (United States)

    Chai, Patrick R.; Merrill, Raymond G.; Qu, Min

    2015-01-01

    NASA's Human Spaceflight Architecture Team is developing a reusable hybrid transportation architecture in which both chemical and electric propulsion systems are used to send crew and cargo to Mars destinations such as Phobos, Deimos, the surface of Mars, and other orbits around Mars. By combining chemical and electrical propulsion into a single spaceship and applying each where it is more effective, the hybrid architecture enables a series of Mars trajectories that are more fuel-efficient than an all chemical architecture without significant increases in flight times. This paper shows the feasibility of the hybrid transportation architecture to pre-deploy cargo to Mars and Phobos in support of the Evolvable Mars Campaign crew missions. The analysis shows that the hybrid propulsion stage is able to deliver all of the current manifested payload to Phobos and Mars through the first three crew missions. The conjunction class trajectory also allows the hybrid propulsion stage to return to Earth in a timely fashion so it can be reused for additional cargo deployment. The 1,100 days total trip time allows the hybrid propulsion stage to deliver cargo to Mars every other Earth-Mars transit opportunity. For the first two Mars surface mission in the Evolvable Mars Campaign, the short trip time allows the hybrid propulsion stage to be reused for three round-trip journeys to Mars, which matches the hybrid propulsion stage's designed lifetime for three round-trip crew missions to the Martian sphere of influence.

  8. 33 CFR 104.275 - Security measures for handling cargo.

    Science.gov (United States)

    2010-07-01

    ... SECURITY MARITIME SECURITY MARITIME SECURITY: VESSELS Vessel Security Requirements § 104.275 Security...) Maritime Security (MARSEC) Level 1. At MARSEC Level 1, the vessel owner or operator must ensure the..., container, or other cargo transport units are loaded; (3) Intensifying screening of vehicles to be loaded on...

  9. Transportation of Nanoscale Cargoes by Myosin Propelled Actin Filaments

    NARCIS (Netherlands)

    Persson, Malin; Gullberg, Maria; Tolf, Conny; Lindberg, A. Michael; Mansson, Alf; Kocer, Armagan

    2013-01-01

    Myosin II propelled actin filaments move ten times faster than kinesin driven microtubules and are thus attractive candidates as cargo-transporting shuttles in motor driven lab-on-a-chip devices. In addition, actomyosin-based transportation of nanoparticles is useful in various fundamental studies.

  10. Technical means overview of the oversize cargoes customs control

    Directory of Open Access Journals (Sweden)

    Dukhnitskiy P.S.

    2016-11-01

    Full Text Available this article focuses on the technical means used by the customs authorities when they control oversize cargoes. Customs inspection efficiency improvement as one of the main forms of customs control during the implementation of sampling is possible by the use of technical means of customs control.

  11. Technical means overview of the oversize cargoes customs control

    OpenAIRE

    Dukhnitskiy P.S.

    2016-01-01

    this article focuses on the technical means used by the customs authorities when they control oversize cargoes. Customs inspection efficiency improvement as one of the main forms of customs control during the implementation of sampling is possible by the use of technical means of customs control.

  12. Bicaudal-D: Switching motors, cargo and direction

    NARCIS (Netherlands)

    G.D. Splinter (Daniël)

    2008-01-01

    textabstractScope of this thesis Transport of vesicles and organelles is an essential cellular process. Proteins like Rab GTPases, specialized adaptor proteins and motor proteins are involved in targeting and movement of cargos to their destination. This thesis describes the function of the

  13. Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery

    NARCIS (Netherlands)

    Prevo, Bram; Scholey, Jonathan M.; Peterman, Erwin J. G.

    Intraflagellar transport (IFT) is a form of motor-dependent cargo transport that is essential for the assembly, maintenance, and length control of cilia, which play critical roles in motility, sensory reception, and signal transduction in virtually all eukaryotic cells. During IFT, anterograde

  14. 46 CFR 153.955 - Warning signs during cargo transfer.

    Science.gov (United States)

    2010-10-01

    ... to a dock or at anchor in port, the master shall ensure that the tankship displays a warning sign at... Cargo. (3) No Visitors. (4) No Smoking. (5) No Open Lights. (c) Each letter must be block style, black on a white background. (d) Each letter must: (1) Be 7.5 cm (approx. 3 in.) high; (2) Be 5 cm (approx...

  15. Abdominal compartment syndrome successfully treated with neuromuscular blockade

    Directory of Open Access Journals (Sweden)

    Kris T Chiles

    2011-01-01

    Full Text Available A 48 year old male admitted to the intensive care unit after a cardiac arrest complicated by a stroke intra-operatively during automatic implantable cardioverter defibrillator placement. He post-operatively developed a rigid abdomen, elevated peak and plateau pressures, hypoxia and renal insufficiency. He was diagnosed with abdominal compartment syndrome with an intra-abdominal compartment pressure of 40mmHg. The patient was administered 10 mg of intravenous cisatracuriumbesylate in preparation for bedside surgical abdominal decompression. Cisatracurium eliminated the patients need for surgical intervention by reducing his abdominal compartment pressures to normal and improving his hypoxia and renal function. This case illustrates that neuromuscular blockade should be attempted in patients with abdominal compartment syndrome prior to surgical intervention.

  16. Environmental fate and transport analysis with compartment modeling

    National Research Council Canada - National Science Library

    Little, Keith W

    2012-01-01

    .... Discussing various modeling issues in a single volume, this text provides an introduction to a specific numerical modeling technique called the compartment approach and offers a practical user's guide to the GEM...

  17. 46 CFR 30.10-5a - Cargo area-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo area-TB/ALL. 30.10-5a Section 30.10-5a Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-5a Cargo area—TB/ALL. The term cargo area means that part of a vessel that includes the cargo tanks and...

  18. Measuring Compartment Size and Gas Solubility in Marine Mammals

    Science.gov (United States)

    2015-09-30

    Koopman, H.N. and A.J. Westgate, Solubility of nitrogen in marine mammal blubber depends on its lipid composition. Journal of Experimental Biology...1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Measuring Compartment Size and Gas Solubility in Marine...is to develop methods to estimate marine mamal tissue compartment sizes, and tissue gas solubility . We aim to improve the data available for the

  19. Compartment syndrome after intramedullary nailing of the tibia.

    Science.gov (United States)

    Tischenko, G J; Goodman, S B

    1990-01-01

    Three patients had compartment syndrome of the leg after tibial intramedullary nailing with reaming. They were all treated successfully with emergency fasciotomy. A prospective study was done of seven additional patients who had continual monitoring of the pressure in the deep posterior compartment during tibial intramedullary nailing with reaming. In five of them, the procedure was performed three weeks or less after injury and in the remaining two, the nailing was performed later for the treatment of non-union. Two pressure peaks in the deep posterior compartment were noted: one after strong longitudinal traction was applied and the fracture was reduced and the other during intramedullary reaming. Intraoperative pressure of thirty millimeters of mercury or more were recorded in three of the seven patients. In the treatment of tibial fractures, operative procedures that involve forceful traction for a long time may predispose the patient to compartment syndrome in the leg. Close clinical observation of such patients is needed. When there is a high risk of compartment syndrome, monitoring of the pressure in the compartment may be prudent.

  20. 46 CFR 154.650 - Cargo tank and process pressure vessel welding.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo tank and process pressure vessel welding. 154.650... Equipment Construction § 154.650 Cargo tank and process pressure vessel welding. (a) Cargo tank and process pressure vessel welding must meet Subpart 54.05 and Part 57 of this chapter. (b) Welding consumables used...

  1. 46 CFR 30.10-5b - Cargo control station-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo control station-TB/ALL. 30.10-5b Section 30.10-5b Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-5b Cargo control station—TB/ALL. The term cargo control station means a location that is manned...

  2. 46 CFR 32.50-3 - Cargo discharge-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo discharge-TB/ALL. 32.50-3 Section 32.50-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Pumps, Piping, and Hose for Cargo Handling § 32.50-3 Cargo discharge—TB/ALL. (a) Pumps or other...

  3. 46 CFR 153.235 - Exceptions to cargo piping location restrictions.

    Science.gov (United States)

    2010-10-01

    ....230(b), 153.231(b), and 153.234(b) unless the cargo piping: (a) Drains back to the cargo tank under any heel or trim resulting from the damage specified in § 172.135 of this chapter; and (b) Enters the cargo tank above the liquid level for a full tank in any condition of heel or trim resulting from the...

  4. 33 CFR 157.37 - Discharge of oily mixtures from oil cargoes.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Discharge of oily mixtures from... CARRYING OIL IN BULK Vessel Operation § 157.37 Discharge of oily mixtures from oil cargoes. (a) A tank vessel may not discharge an oily mixture into the sea from a cargo tank, slop tank, or cargo pump room...

  5. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section 1917..., DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Marine Terminal Operations § 1917.22 Hazardous cargo 2 (See... related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR...

  6. 14 CFR 297.30 - Public disclosure of cargo liability insurance.

    Science.gov (United States)

    2010-01-01

    ... ASSOCIATIONS General Rules for Foreign Indirect Air Carriers § 297.30 Public disclosure of cargo liability... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Public disclosure of cargo liability... shipment is accepted, of the limits of its cargo liability insurance, or of the absence of such insurance...

  7. Safety evaluation for packaging (Onsite) transport of LSA-II liquids in MC-312 cargo tanks

    International Nuclear Information System (INIS)

    Carlstrom, R.F.

    1996-01-01

    This safety evaluation for packaging authorizes the onsite transfer of bulk LSA-II radioactive liquids in the 222-S Laboratory Cargo Tank and Liquid Effluent Treatment Facility Cargo Tanks (which are U.S. Department of Transportation MC-312 specification cargo tanks) from their operating facilities to tank farm facilities

  8. Investigate existing non-intrusive (NII) technologies for port cargo inspections.

    Science.gov (United States)

    2011-09-01

    "The quantity of cargo handled by United States ports has increased significantly in recent years. Based on : 2004 data, almost 2.7 billion tons of cargo passed through the ports in one year. To protect the U.S., all of this : cargo must be inspected...

  9. 33 CFR 126.17 - Permits required for handling designated dangerous cargo.

    Science.gov (United States)

    2010-07-01

    ... designated cargoes are not removed from, or placed in, the railroad car or highway vehicle while it is in or... HOMELAND SECURITY (CONTINUED) WATERFRONT FACILITIES HANDLING OF DANGEROUS CARGO AT WATERFRONT FACILITIES... discretion of the Captain of the Port, when such cargoes are contained within railroad cars or highway...

  10. 46 CFR 154.701 - Cargo pressure and temperature control: General.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo pressure and temperature control: General. 154.701... Equipment Cargo Pressure and Temperature Control § 154.701 Cargo pressure and temperature control: General... the MARVS under § 154.405; or (b) Be refrigerated by a system meeting § 154.702, and each refrigerated...

  11. 49 CFR 173.33 - Hazardous materials in cargo tank motor vehicles.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Hazardous materials in cargo tank motor vehicles... Transportation § 173.33 Hazardous materials in cargo tank motor vehicles. (a) General requirements. (1) No person may offer or accept a hazardous material for transportation in a cargo tank motor vehicle except as...

  12. 46 CFR 153.371 - Minimum relief valve setting for refrigerated cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... Design and Equipment Cargo Venting Systems § 153.371 Minimum relief valve setting for refrigerated cargo... steady state temperature obtained by a full tank of cargo with the refrigeration system operating under ambient conditions described within the definition of a refrigerated tank in § 153.2. ...

  13. The role of each compartment in a two-compartment vertical flow reactor for ferruginous mine water treatment.

    Science.gov (United States)

    Yim, G J; Cheong, Y W; Hong, J H; Hur, W

    2014-10-01

    A vertical flow reactor (VFR) has been suggested for remediation of ferruginous mine drainage that passes down through an accreting bed of ochre. However, a VFR has a limited operation time until the system begins to overflow. In this study, a mathematical model was developed as a part of the effort to explore the operation of a VFR, showing dynamic changes in the head differences, ochre depths, and Fe(II)/Fe(III) concentrations in the effluent flow. The analysis showed that VFR operation time extended from 148.5 days to 163 days in an equally divided and to 168.4 days in asymmetrically (0.72:0.28) divided two-compartment VFR, suggesting that an optimum compartment ratio exists that maximizes the VFR operation time. A constant head filtration in the first compartment maximized filtration efficiency and thus prolonged VFR longevity in the two-compartment VFR. Fe(II) oxidation and ochre formation should be balanced with the permeability of the ochre bed to maximize the VFR operation time and minimize the residual Fe(II) in the effluent. Accelerated Fe(II) oxidation affected the optimum ratio of the compartment area and reduced the residual Fe(II) in the effluent. The VFR operation time can be prolonged significantly from 764 days to 3620 days by increasing the rate of ochre formation, much more than by accelerating the Fe(II) oxidation. During the prolonged VFR operation, ochre formed largely in the first compartment, while overflowing mine water with reduced iron content was effectively filtered in the second compartment. These results not only provide a better understanding of VFR operation but also suggest the direction of evolution of two-compartment VFR toward a compact and highly efficient facility integrated with an aerated cascade and with automatic coagulant feeding. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Network model of cargo processing in containers in the sea ports of Ukraine

    Directory of Open Access Journals (Sweden)

    Светлана Петровна Онищенко

    2016-03-01

    Full Text Available It is identified the number of operations on cargo processing in containers in the sea ports of Ukraine and build a logical model of the relationship for the members of cargo service. It is developed a network model of cargo processing in containers in the sea ports of Ukraine as a tool for coordination of operations during processing. The used method allows creating an effective cargo processing plan and identifying and reducing the period of container location with cargo in the port

  15. Numerical modelling of crural fascia mechanical interaction with muscular compartments.

    Science.gov (United States)

    Pavan, Piero G; Pachera, Paola; Natali, Arturo N

    2015-05-01

    The interaction of the crural fascia with muscular compartments and surrounding tissues can be at the origin of different pathologies, such as compartment syndrome. This pathology consists in the onset of excessive intracompartmental pressure, which can have serious consequences for the patient, compromising blood circulation. The investigation of compartment syndrome etiology also takes into account the alteration of crural fascia mechanical properties as a cause of the syndrome, where the fascial stiffening would result in the rise of intracompartmental pressure. This work presents a computational approach toward evaluating some biomechanical aspects of the problem, within the context of a more global viewpoint. Finite element analyses of the interaction phenomena of the crural fascia with adjacent regions are reported here. This study includes the effects of a fascial stiffness increase along the proximal-distal direction and their possible clinical implications. Furthermore, the relationship between different pre-strain levels of the crural fascia in the proximal-distal direction and the rise of internal pressure in muscular compartments are considered. The numerical analyses can clarify which aspects could be directly implied in the rise of compartment syndrome, leading to greater insight into muscle-fascia mechanical phenomena, as well as promoting experimental investigation and clinical analysis of the syndrome. © IMechE 2015.

  16. Membrane order in the plasma membrane and endocytic recycling compartment.

    Science.gov (United States)

    Iaea, David B; Maxfield, Frederick R

    2017-01-01

    The cholesterol content of membranes plays an important role in organizing membranes for signal transduction and protein trafficking as well as in modulating the biophysical properties of membranes. While the properties of model or isolated membranes have been extensively studied, there has been little evaluation of internal membranes in living cells. Here, we use a Nile Red based probe, NR12S, and ratiometric live cell imaging, to analyze the membrane order of the plasma membrane and endocytic recycling compartment. We find that after a brief incubation to allow endocytosis, NR12S is distributed between the plasma membrane and the endocytic recycling compartment. The NR12S reports that the endocytic recycling compartment is more highly ordered than the plasma membrane. We also find that the plasma membrane and the endocytic recycling compartment are differentially affected by altering cellular cholesterol levels. The membrane order of the plasma membrane, but not the endocytic recycling compartment, is altered significantly when cellular cholesterol content is increased or decreased by 20%. These results demonstrate that changes in cellular cholesterol differentially alter membrane order within different organelles.

  17. Implementation of cargo MagLev in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Rose, Chris R [Los Alamos National Laboratory; Peterson, Dean E [Los Alamos National Laboratory; Leung, Eddie M [MAGTEC ENGINEERING

    2008-01-01

    Numerous studies have been completed in the United States, but no commercial MagLev systems have been deployed. Outside the U.S., MagLev continues to attract funding for research, development and implementation. A brief review of recent global developments in MagLev technology is given followed by the status of MagLev in the U.S. The paper compares the cost of existing MagLev systems with other modes of transport, notes that the near-term focus of MagLev development in the U.S. should be for cargo, and suggests that future MagLev systems should be for very high speed cargo. The Los Angeles to Port of Los Angeles corridor is suggested as a first site for implementation. The benefits of MagLev are described along with suggestions on how to obtain funding.

  18. Fixing Trailer Hitch for Roof Rack of Cargos

    Directory of Open Access Journals (Sweden)

    Darina Matisková

    2017-02-01

    Full Text Available This article presents a new technical solution of fixing trailer hitch which serves as a connection between single track vehicle and cargo, mainly light trailer. They are manufactured from steel girder and nets which are constructed by point welding. They are designed to indicate the necessary solidity and the required load bearing capacity of the cargo. The application of roof racks is universal and these products are in great demand in the field of game management. There are a lot of trailer hitches which the manufacturers tailor to customers´ demands. The stated technical solution is subject of published industrial utility model at the Industrial property office of the Slovak republic.

  19. Shared value potential of transporting cargo via hyperloop

    OpenAIRE

    Werner, Max; Eißing, Klaus; Langton, Sebastian

    2016-01-01

    This research estimates the shared value created by constructing a hypothetical Hyperloop to transport cargo along 300 km in Northern Germany. Following Porter and Kramer (2011, 2012), we identified and evaluated eight factors that create shared value: travel speed, operating costs, safety, noise pollution, air pollution, climate effect/carbon footprint, separation effect/property efficiency, and maintenance. Using official data compiled by several German institutes and organizations, we cond...

  20. Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery.

    Science.gov (United States)

    Prevo, Bram; Scholey, Jonathan M; Peterman, Erwin J G

    2017-09-01

    Intraflagellar transport (IFT) is a form of motor-dependent cargo transport that is essential for the assembly, maintenance, and length control of cilia, which play critical roles in motility, sensory reception, and signal transduction in virtually all eukaryotic cells. During IFT, anterograde kinesin-2 and retrograde IFT dynein motors drive the bidirectional transport of IFT trains that deliver cargo, for example, axoneme precursors such as tubulins as well as molecules of the signal transduction machinery, to their site of assembly within the cilium. Following its discovery in Chlamydomonas, IFT has emerged as a powerful model system for studying general principles of motor-dependent cargo transport and we now appreciate the diversity that exists in the mechanism of IFT within cilia of different cell types. The absence of heterotrimeric kinesin-2 function, for example, causes a complete loss of both IFT and cilia in Chlamydomonas, but following its loss in Caenorhabditis elegans, where its primary function is loading the IFT machinery into cilia, homodimeric kinesin-2-driven IFT persists and assembles a full-length cilium. Generally, heterotrimeric kinesin-2 and IFT dynein motors are thought to play widespread roles as core IFT motors, whereas homodimeric kinesin-2 motors are accessory motors that mediate different functions in a broad range of cilia, in some cases contributing to axoneme assembly or the delivery of signaling molecules but in many other cases their ciliary functions, if any, remain unknown. In this review, we focus on mechanisms of motor action, motor cooperation, and motor-dependent cargo delivery during IFT. © 2017 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

  1. Increased pressure within the abdominal compartment: intra-abdominal hypertension and the abdominal compartment syndrome.

    Science.gov (United States)

    Roberts, Derek J; Ball, Chad G; Kirkpatrick, Andrew W

    2016-04-01

    This article reviews recent developments related to intra-abdominal hypertension (IAH)/abdominal compartment syndrome (ACS) and clinical practice guidelines published in 2013. IAH/ACS often develops because of the acute intestinal distress syndrome. Although the incidence of postinjury ACS is decreasing, IAH remains common and associated with significant morbidity and mortality among critically ill/injured patients. Many risk factors for IAH include those findings suggested to be indications for use of damage control surgery in trauma patients. Medical management strategies for IAH/ACS include sedation/analgesia, neuromuscular blocking and prokinetic agents, enteral decompression tubes, interventions that decrease fluid balance, and percutaneous catheter drainage. IAH/ACS may be prevented in patients undergoing laparotomy by leaving the abdomen open where appropriate. If ACS cannot be prevented with medical or surgical management strategies or treated with percutaneous catheter drainage, guidelines recommend urgent decompressive laparotomy. Use of negative pressure peritoneal therapy for temporary closure of the open abdomen may improve the systemic inflammatory response and patient-important outcomes. In the last 15 years, investigators have better clarified the pathogenesis, epidemiology, diagnosis, and appropriate prevention of IAH/ACS. Subsequent study should be aimed at understanding which treatments effectively lower intra-abdominal pressure and whether these treatments ultimately affect patient-important outcomes.

  2. Exercise Induced Rhabdomyolysis with Compartment Syndrome and Renal Failure

    Directory of Open Access Journals (Sweden)

    Mary Colleen Bhalla

    2014-01-01

    Full Text Available Exertional rhabdomyolysis is sequela that is occasionally seen after strenuous exercise. The progression to compartment syndrome or renal failure is a rare complication that requires prompt recognition and treatment to prevent morbidity (Giannoglou et al. 2007. We present a case of a 22-year-old college football player who presented to the emergency department (ED after a typical leg workout as part of his weight conditioning. He was found to have rhabdomyolysis with evidence of renal insufficiency. His condition progressed to bilateral compartment syndrome and renal failure requiring dialysis. After bilateral fasciotomies were performed he had resolution of his compartment syndrome. He continued to be dialysis dependent and had no return of his renal function at discharge 12 days after admission.

  3. Psittacine paranasal sinus--a new definition of compartments.

    Science.gov (United States)

    Artmann, A; Henninger, W

    2001-12-01

    Documentation of the psittacine paranasal sinuses has been limited. To provide more published detail, spiral computed tomography (CT) was used to scan the cephalic and cervical region from cadavers of 10 psittacine birds (Ara ararauna, Ara chloroptera, Ara macao, and Anodorhynchus hyacinthinus). Skeletal studies, histologic examinations, and evaluation of deep-frozen sections and anatomic preparations confirmed the results of the CT scans. New morphologic details of the paranasal sinus and some compartments were discovered. The paranasal sinuses of these macaws consist of two unpaired rostral compartments, followed caudally by eight paired compartments. Histologic examinations revealed that the walls of the paranasal sinuses consist of flat or cubic monolayer epithelium with underlying connective tissue. The described method of CT examination of these macaws, especially the positioning, scan orientation and parameters, and documentation of the normal paranasal sinus, provides a basis for future clinical use of CT.

  4. 46 CFR 38.05-4 - Design and construction of nonpressure vessel type cargo tanks-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... acceptable. (d) The design and construction of the cargo tanks shall be at least equivalent to the standards...) The cargo tank shall be designed for a head of cargo at least equal to the highest level the liquid... 46 Shipping 1 2010-10-01 2010-10-01 false Design and construction of nonpressure vessel type cargo...

  5. The use of graft materials in anterior compartment pelvic reconstruction.

    Science.gov (United States)

    Begley, J Sean; Kobashi, Kathleen C

    2004-10-01

    Since 1996, the number of reports in the urologic and gynecologic literature using synthetic and allograph prosthetics to enhance the durability of anterior compartment repairs have increased significantly. Central to the use of these prosthetics is long-term follow-up to demonstrate that their use actually confers a benefit to patients and surgeons alike. This review attempts to catalog those reports and the outcomes, with an emphasis on the cadaveric prolapse repair with sling, which is used by the authors for repair of anterior compartment prolapse with overt or occult genuine stress urinary incontinence.

  6. Cellular endocytic compartment localization of expressed canine CD1 molecules.

    Science.gov (United States)

    Schjaerff, Mette; Keller, Stefan M; Affolter, Verena K; Kristensen, Annemarie T; Moore, Peter F

    2016-12-01

    CD1 molecules are glycoproteins present primarily on dendritic cells (DCs), which recognize and present a variety of foreign- and self-lipid antigens to T-cells. Humans have five different CD1 isoforms that survey distinct cellular compartments allowing for recognition of a large repertoire of lipids. The canine CD1 family consists of seven functional CD1 molecules (canine CD1a2, CD1a6, CD1a8, CD1a9, CD1b, CD1c and CD1e) and one presumed non-functional isoform (canine CD1d) due to a disrupted gene structure. The aim of this study was to describe in vitro steady-state localization ptterns of canine CD1 isoforms and their correlation with endocytic organelles. GFP-fused canine CD1 293T cell transfectants were stained with markers for early endocytic compartments (EEA-1) and late endocytic/lysosomal compartments (LAMP-1), respectively, and analyzed by confocal microscopy. Canine CD1a molecules localized to the plasma membrane and partially to the early endocytic compartment, but not to late endosomes or lysosomes. In contrast, canine CD1b was highly associated with late endosomal/lysosomal compartments and showed a predominant intracellular expression pattern. Canine CD1c protein expression localized more promiscuously to both the early endosomal compartments and the late endosomal/lysosomal compartments. The canine CD1e molecule showed a strictly intracellular expression with a partial overlap with late endosomal/lysosomal compartments. Lastly, canine CD1d was expressed abnormally showing only a diminished GFP expression. In conclusion, canine CD1 transfectants show distinct localization patterns that are similar to human CD1 proteins with the exception of the canine CD1d isoform, which most likely is non-functional. These findings imply that canine CD1 localization overall resembles human CD1 trafficking patterns. This knowledge is important for the understanding of lipid antigen-receptor immunity in the dog. Copyright © 2016. Published by Elsevier B.V.

  7. National Security Science and Technology Initiative: Air Cargo Screening

    Energy Technology Data Exchange (ETDEWEB)

    Bingham, Philip R [ORNL; White, Tim [Pacific Northwest National Laboratory (PNNL); Cespedes, Ernesto [Idaho National Laboratory (INL); Bowerman, Biays [Brookhaven National Laboratory (BNL); Bush, John [Battelle

    2010-11-01

    The non-intrusive inspection (NII) of consolidated air cargo carried on commercial passenger aircraft continues to be a technically challenging, high-priority requirement of the Department of Homeland Security's Science and Technology Directorate (DHS S&T), the Transportation Security Agency and the Federal Aviation Administration. The goal of deploying a screening system that can reliably and cost-effectively detect explosive threats in consolidated cargo without adversely affecting the flow of commerce will require significant technical advances that will take years to develop. To address this critical National Security need, the Battelle Memorial Institute (Battelle), under a Cooperative Research and Development Agreement (CRADA) with four of its associated US Department of Energy (DOE) National Laboratories (Oak Ridge, Pacific Northwest, Idaho, and Brookhaven), conducted a research and development initiative focused on identifying, evaluating, and integrating technologies for screening consolidated air cargo for the presence of explosive threats. Battelle invested $8.5M of internal research and development funds during fiscal years 2007 through 2009. The primary results of this effort are described in this document and can be summarized as follows: (1) Completed a gap analysis that identified threat signatures and observables, candidate technologies for detection, their current state of development, and provided recommendations for improvements to meet air cargo screening requirements. (2) Defined a Commodity/Threat/Detection matrix that focuses modeling and experimental efforts, identifies technology gaps and game-changing opportunities, and provides a means of summarizing current and emerging capabilities. (3) Defined key properties (e.g., elemental composition, average density, effective atomic weight) for basic commodity and explosive benchmarks, developed virtual models of the physical distributions (pallets) of three commodity types and three

  8. Final Report, Next-Generation Mega-Voltage Cargo-Imaging System for Cargo Container Inspection, March 2007

    International Nuclear Information System (INIS)

    Dr. James Clayton, Ph.D., Varian Medical Systems-Security and Inspection Products; Dr. Emma Regentova, Ph.D, University of Nevada Las Vegas; Dr. Evangelos Yfantis, Ph.D., University of Nevada, Las Vegas

    2007-01-01

    The UNLV Research Foundation, as the primary award recipient, teamed with Varian Medical Systems-Security and Inspection Products and the University of Nevada Las Vegas (UNLV) for the purpose of conducting research and engineering related to a ''next-generation'' mega-voltage imaging (MVCI) system for inspection of cargo in large containers. The procurement and build-out of hardware for the MVCI project has been completed. The K-9 linear accelerator and an optimized X-ray detection system capable of efficiently detecting X-rays emitted from the accelerator after they have passed through the device is under test. The Office of Science financial assistance award has made possible the development of a system utilizing a technology which will have a profound positive impact on the security of U.S. seaports. The proposed project will ultimately result in critical research and development advances for the ''next-generation'' Linatron X-ray accelerator technology, thereby providing a safe, reliable and efficient fixed and mobile cargo inspection system, which will very significantly increase the fraction of cargo containers undergoing reliable inspection as the enter U.S. ports. Both NNSA/NA-22 and the Department of Homeland Security's Domestic Nuclear Detection Office are collaborating with UNLV and its team to make this technology available as soon as possible

  9. How molecular motors are arranged on a cargo is important for vesicular transport.

    Directory of Open Access Journals (Sweden)

    Robert P Erickson

    2011-05-01

    Full Text Available The spatial organization of the cell depends upon intracellular trafficking of cargos hauled along microtubules and actin filaments by the molecular motor proteins kinesin, dynein, and myosin. Although much is known about how single motors function, there is significant evidence that cargos in vivo are carried by multiple motors. While some aspects of multiple motor function have received attention, how the cargo itself--and motor organization on the cargo--affects transport has not been considered. To address this, we have developed a three-dimensional Monte Carlo simulation of motors transporting a spherical cargo, subject to thermal fluctuations that produce both rotational and translational diffusion. We found that these fluctuations could exert a load on the motor(s, significantly decreasing the mean travel distance and velocity of large cargos, especially at large viscosities. In addition, the presence of the cargo could dramatically help the motor to bind productively to the microtubule: the relatively slow translational and rotational diffusion of moderately sized cargos gave the motors ample opportunity to bind to a microtubule before the motor/cargo ensemble diffuses out of range of that microtubule. For rapidly diffusing cargos, the probability of their binding to a microtubule was high if there were nearby microtubules that they could easily reach by translational diffusion. Our simulations found that one reason why motors may be approximately 100 nm long is to improve their 'on' rates when attached to comparably sized cargos. Finally, our results suggested that to efficiently regulate the number of active motors, motors should be clustered together rather than spread randomly over the surface of the cargo. While our simulation uses the specific parameters for kinesin, these effects result from generic properties of the motors, cargos, and filaments, so they should apply to other motors as well.

  10. Instant conditional transgenesis in the mouse hematopoietic compartment

    NARCIS (Netherlands)

    Csikós, Tamás; Reijmers, Rogier M.; Uren, Anthony G.; Spaargaren, Marcel; Pals, Steven T.

    2008-01-01

    Adoptive transfer of retrovirally transduced stem cells has recently been described for instant transgenesis in the hematopoietic compartment of mice. This method circumvents the need to manipulate the germline. However, cell type specific gene expression in this 'retrogenic' mouse model has

  11. The anammoxosome : An intracytoplasmic compartment in anammox bacteria

    NARCIS (Netherlands)

    Sinninghe Damsté, J.S.; Niftrik, L.A. van; Fuerst, J.A.; Kuenen, J.G.; Jetten, M.S.M.; Strous, M.

    2004-01-01

    Anammox bacteria belong to the phylum Planctomycetes and perform anaerobic ammonium oxidation (anammox); they oxidize ammonium with nitrite as the electron acceptor to yield dinitrogen gas. The anammox reaction takes place inside the anammoxosome: an intracytoplasmic compartment bounded by a single

  12. The anammoxosome: an intracytoplasmic compartment in anammox bacteria

    NARCIS (Netherlands)

    Niftrik, L.A.M.P. van; Fuerst, J.A.; Damste, J.S.S.; Kuenen, J.G.; Jetten, M.S.M.; Strous, M.

    2004-01-01

    Anammox bacteria belong to the phylum Planctomycetes and perform anaerobic ammonium oxidation (anammox); they oxidize ammonium with nitrite as the electron acceptor to yield dinitrogen gas. The anammox reaction takes place inside the anammoxosome: an intracytoplasmic compartment bounded by a single

  13. "Compartment"-syndrom på underben, atypisk traumemekanisme

    DEFF Research Database (Denmark)

    Larsen, Michael H; Nielsen, Henrik Toft; Wester, Jens Ulrik

    2003-01-01

    Acute compartment syndrome (CS) is a limb threatening condition which warrants emergency treatment. We describe a case of a 37-year-old man with acute CS developed without major trauma. Early diagnosis and prompt treatment by decompressive fasciotomy is of vital importance in order to preserve limb...

  14. latrogenic chronic compartment syndrome of leg due to ruptured ...

    African Journals Online (AJOL)

    A 45 year old male complaining of chronic pain and swelling of his left calf with features suggestive of chronic compartment syndrome following therapeutic aspiration of a popliteal cyst has been presented. It is a rare type of presentation which has not been reported to the knowledge of the authors. Review of literature and

  15. Evaluation of acute compartment syndrome of extremities in ...

    African Journals Online (AJOL)

    The aim of this study was to analyze the clinical signs of diagnosis, treatment and followup of the pediatric population presenting with acute compartment syndrome in the emergency room at an Institutional Level II trauma center. The study is a prospective case series. Thirty-two samples were selected from Institutional ...

  16. 19 CFR 123.24 - Sealing of conveyances or compartments.

    Science.gov (United States)

    2010-04-01

    ...; DEPARTMENT OF THE TREASURY CUSTOMS RELATIONS WITH CANADA AND MEXICO Shipments in Transit Through Canada or Mexico § 123.24 Sealing of conveyances or compartments. (a) Sealing required. Merchandise in transit...-bound seals may go forward without additional seals. (c) Carrier relieved of responsibility. The port...

  17. Chronic exertional compartment syndrome in the forearm of a rower

    African Journals Online (AJOL)

    2 2014. CASE STUDY. This case report describes chronic exertional compartment syndrome in the forearm of a professional rower. We consider this to be a rare anatomical location for this type of syndrome. Morever, not much is known about its clinical presentation and the subsequent optimal medical management thereof ...

  18. A wolf in wolf's clothing the abdominal compartment syndrome

    African Journals Online (AJOL)

    abdomen. These findings are consistent with the diagnosis of intra-abdominal compartment syndrome. In 1 case trauma was remote from the abdomen .... although they tend to develop most often in those who have undergone major vascular operations or suffered abdominal trauma. The effects of the pressure on the bowel ...

  19. Well-leg compartment syndrome after gynecological laparoscopic surgery

    DEFF Research Database (Denmark)

    Boesgaard-Kjer, Diana H; Boesgaard-Kjer, Daniel; Kjer, Jens Jørgen

    2013-01-01

    Well-leg compartment syndrome in the lower extremities after surgery in the lithotomy position is a rare but severe complication requiring early diagnosis and intervention. Several circumstances predispose to this condition as a consequence of increased intra-compartmental pressure, such as posit...

  20. Two-Compartment Pharmacokinetic Models for Chemical Engineers

    Science.gov (United States)

    Kanneganti, Kumud; Simon, Laurent

    2011-01-01

    The transport of potassium permanganate between two continuous-stirred vessels was investigated to help chemical and biomedical engineering students understand two-compartment pharmacokinetic models. Concepts of modeling, mass balance, parameter estimation and Laplace transform were applied to the two-unit process. A good agreement was achieved…

  1. Evaluation of acute compartment syndrome of extremities in ...

    African Journals Online (AJOL)

    Arun Kumar Agnihotri

    necrotic tissue in the histological examination. In our study, we also observed patchy necrosis of muscle fibers with perifascicular oedema3. We observed ischemic contractures in about 18.7% of our cases. In a series of 24 children with acute compartment syndrome, chronic contractures were reported only in 4.2% cases3.

  2. The abdominal compartment syndrome (ACS) in general surgery.

    Science.gov (United States)

    Bodnár, Zsolt; Sipka, Sándor; Hajdu, Zoltán

    2008-01-01

    The abdominal compartment syndrome is a life threatening clinical entity which can develop within the first 12 hours of intensive care unit admission in high-risk surgical patients. The aim of this paper is to show the definitions, ethiology, pathophysiology, diagnosis and treatment of this serious, not only surgical problem. The mortality due to the abdominal compartment syndrome is extremely high (38-71%). It can be defined as adverse physiologic consequences that occur as a result of an acute increase in the intraabdominal pressure. The most common causes are retroperitoneal haemorrhage, visceral oedema, pancreatitis, bowel obstruction, tense ascites, peritonitis, tumor. The mostly affected systems are cardiovascular, pulmonary, renal, central nervous systems and splanchnic organs. The gold standard diagnostic method is the continuous intra-abdominal pressure monitoring. The treatment consists of adequate fluid resuscitation and surgical decompression. We show three typical short case reports treated by the above mentioned theories. Intraabdominal hypertension and abdominal compartment syndrome are frequent clinical findings among acute general surgical patients. Patients with comparable demographics and acute severity of illness are more likely to die if intraabdominal hypertension or abdominal compartment syndrome is present. We conclude that the early recognition and surgical decompression is urgent.

  3. Recurrent Metachronous Acute Compartment Syndrome in the Legs ...

    African Journals Online (AJOL)

    METHODS: A seven-year-old boy presented with four separate episodes of acute compartment syndrome of the legs within three years. The recurrent nature of the illness prompted detail review of the records of the child. RESULTS: There was involvement of each leg twice between the ages of three and seven years ...

  4. 14 CFR 121.269 - Extinguishing agent container compartment temperature.

    Science.gov (United States)

    2010-01-01

    ... temperature. 121.269 Section 121.269 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF....269 Extinguishing agent container compartment temperature. Precautions must be taken to insure that the extinguishing agent containers are installed in places where reasonable temperatures can be...

  5. 14 CFR 125.167 - Extinguishing agent container compartment temperature.

    Science.gov (United States)

    2010-01-01

    ... temperature. 125.167 Section 125.167 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Requirements § 125.167 Extinguishing agent container compartment temperature. Precautions must be taken to ensure that the extinguishing agent containers are installed in places where reasonable temperatures can...

  6. 14 CFR 135.170 - Materials for compartment interiors.

    Science.gov (United States)

    2010-01-01

    ... 26, 1984. (c) Thermal/acoustic insulation materials. For transport category airplanes type... manufactured after September 2, 2005, thermal/acoustic insulation materials installed in the fuselage must meet... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Materials for compartment interiors. 135...

  7. Abdominal compartment syndrome in patients with strangulated hernia.

    Science.gov (United States)

    Beltrán, M A; Villar, R A; Cruces, K S

    2008-12-01

    Intestinal obstruction (IO) leads to increased intra-abdominal pressure and abdominal compartment syndrome. The purpose of this study was to investigate the characteristics of abdominal compartment syndrome in patients with IO secondary to strangulated hernia. We studied 81 consecutive unselected patients presenting complicated hernias and IO. We measured intra-abdominal pressure using the intra-vesicular pressure method. Preoperative (15 min) intra-abdominal pressure was higher in patients with strangulated hernias. Postoperative (15 min) intra-abdominal pressure in both groups decreased to similar values. Intra-abdominal pressure was measured during the preoperative period in patients with strangulated hernias and during the postoperative period at 15 min (13.8 +/- 6.4 mmHg), 24 h (9.8 +/- 3.2 mmHg) and 48 h (7.4 +/- 2.4 mmHg). Abdominal compartment syndrome developed in 47% cases with strangulated hernias with a mortality of five patients. Serial measurements of intra-abdominal pressure evidenced the clinical severity of strangulated hernia. Intra-abdominal pressure measurement may be used as a predictor of intestinal strangulation in patients presenting acute abdominal compartment syndrome secondary to complicated hernia.

  8. Organic nano-compartments as biomimetic reactors, and protocells

    DEFF Research Database (Denmark)

    Monnard, Pierre-Alain; Ziock, Hans-Joachim; DeClue, Michael S.

    2008-01-01

    In recent years, nanoscale self-assembled structures have attracted ever increasing attention because of their potential to act as molecular templates for the synthesis of novel materials, delivery vehicles for therapeutic agents, and compartments defined at the molecular level that provide envir...

  9. Volume of the effect compartment in simulations of neuromuscular block

    NARCIS (Netherlands)

    Nigrovic, Vladimir; Proost, Johannes H.; Amann, Anton; Bhatt, Shashi B.

    2005-01-01

    Background: The study examines the role of the volume of the effect compartment in simulations of neuromuscular block (NMB) produced by nondepolarizing muscle relaxants. Methods: The molar amount of the postsynaptic receptors at the motor end plates in muscle was assumed constant; the apparent

  10. Compartment specific importance of glutathione during abiotic and biotic stress

    Directory of Open Access Journals (Sweden)

    Bernd eZechmann

    2014-10-01

    Full Text Available The tripeptide thiol glutathione (γ-L-glutamyl-L-cysteinyl-glycine is the most important sulfur containing antioxidant in plants and essential for plant defense against abiotic and biotic stress conditions. It is involved in the detoxification of reactive oxygen species, redox signaling, the modulation of defense gene expression and important for the regulation of enzymatic activities. Even though changes in glutathione contents are well documented in plants and its roles in plant defense are well established, still too little is known about its compartment specific importance during abiotic and biotic stress conditions. Due to technical advances in the visualization of glutathione and the redox state of plants through microscopical methods some progress was made in the last few years in studying the importance of subcellular glutathione contents during stress conditions in plants. This review summarizes the data available on compartment specific importance of glutathione in the protection against abiotic and biotic stress conditions such as high light stress, exposure to cadmium, drought, and pathogen attack (Pseudomonas, Botrytis, Tobacco Mosaic Virus. The data will be discussed in connection with the subcellular accumulation of ROS during these conditions and glutathione synthesis which are both highly compartment specific (e.g. glutathione synthesis takes place in chloroplasts and the cytosol. Thus this review will reveal the compartment specific importance of glutathione during abiotic and biotic stress conditions.

  11. Lower extremity compartment sindrome following coronary artery bypass.

    Science.gov (United States)

    Papas, T T; Mikroulis, D; Papanas, N; Lazarides, M K; Bougioukas, G

    2007-04-01

    Compartment syndrome is a constellation of symptoms and signs associated with abnormally elevated tissue pressure in the skeletal muscle of the extremities. It is manifested in anatomic locations where muscles are enveloped in fasciae. The case of a lower extremity compartment syndrome in a 71-year-old male patient who underwent coronary artery bypass grafting (CABG) and simultaneous aortic valve surgery is reported. Preoperative evaluation revealed severe peripheral vascular disease. The patient underwent triple CABG using the left internal thoracic artery and two vein grafts. The right great saphenous vein was used for these vein grafts. The aortic valve was replaced with a biologic prosthesis. On postoperative day 1, the patient complained of pain and oedema in the right calf. The next day, symptoms worsened, with marked sensory loss, motor weakness and foot drop in the affected limb. Triplex ultrasonography excluded deep vein thrombosis. Compartment syndrome was diagnosed and successfully managed by fasciotomy. This case illustrates that compartment syndrome may, although rarely, be a complication of CABG.

  12. Surgical treatment for ~brain compartment syndrome' in children ...

    African Journals Online (AJOL)

    Objectives. Traumatic brain injury accounts for a high percentage of deaths in children. Raised intracranial pressure (ICP) due to brain swelling within the closed compartment of the skull leads to death or severe neurological disability if not effectively treated. We report our experience with 12 children who presented with ...

  13. Ward Round - Late Presentation of Acute Compartment Syndrome in ...

    African Journals Online (AJOL)

    following the course of ibuprofen mentioned. Twelve days after admission he started to complain of increasing pain and tightness in his left thigh. Sensation and motor function. Ward Round - Late Presentation of Acute. Compartment Syndrome in the Thigh. University of Malawi, College of Medicine, Department of Surgery,.

  14. Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment

    Directory of Open Access Journals (Sweden)

    Anne F. J. Janssen

    2017-08-01

    Full Text Available The selective transport of different cargoes into axons and dendrites underlies the polarized organization of the neuron. Although it has become clear that the combined activity of different motors determines the destination and selectivity of transport, little is known about the mechanistic details of motor cooperation. For example, the exact role of myosin-V in opposing microtubule-based axon entries has remained unclear. Here we use two orthogonal chemically-induced heterodimerization systems to independently recruit different motors to cargoes. We find that recruiting myosin-V to kinesin-propelled cargoes at approximately equal numbers is sufficient to stall motility. Kinesin-driven cargoes entering the axon were arrested in the axon initial segment (AIS upon myosin-V recruitment and accumulated in distinct actin-rich hotspots. Importantly, unlike proposed previously, myosin-V did not return these cargoes to the cell body, suggesting that additional mechanism are required to establish cargo retrieval from the AIS.

  15. X-ray scan detection for cargo integrity

    Science.gov (United States)

    Valencia, Juan; Miller, Steve

    2011-04-01

    The increase of terrorism and its global impact has made the determination of the contents of cargo containers a necessity. Existing technology allows non-intrusive inspections to determine the contents of a container rapidly and accurately. However, some cargo shipments are exempt from such inspections. Hence, there is a need for a technology that enables rapid and accurate means of detecting whether such containers were non-intrusively inspected. Non-intrusive inspections are most commonly performed utilizing high powered X-ray equipment. The challenge is creating a device that can detect short duration X-ray scans while maintaining a portable, battery powered, low cost, and easy to use platform. The Pacific Northwest National Laboratory (PNNL) has developed a methodology and prototype device focused on this challenge. The prototype, developed by PNNL, is a battery powered electronic device that continuously measures its X-ray and Gamma exposure, calculates the dose equivalent rate, and makes a determination of whether the device has been exposed to the amount of radiation experienced during an X-ray inspection. Once an inspection is detected, the device will record a timestamp of the event and relay the information to authorized personnel via a visual alert, USB connection, and/or wireless communication. The results of this research demonstrate that PNNL's prototype device can be effective at determining whether a container was scanned by X-ray equipment typically used for cargo container inspections. This paper focuses on laboratory measurements and test results acquired with the PNNL prototype device using several X-ray radiation levels.

  16. Photonuclear-based Detection of Nuclear Smuggling in Cargo Containers

    Science.gov (United States)

    Jones, J. L.; Haskell, K. J.; Hoggan, J. M.; Norman, D. R.; Yoon, W. Y.

    2003-08-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) and the Los Alamos National Laboratory (LANL) have performed experiments in La Honda, California and at the Idaho Accelerator Center in Pocatello, Idaho to assess and develop a photonuclear-based detection system for shielded nuclear materials in cargo containers. The detection system, measuring photonuclear-related neutron emissions, is planned for integration with the ARACOR Eagle Cargo Container Inspection System (Sunnyvale, CA). The Eagle Inspection system uses a nominal 6-MeV electron accelerator and operates with safe radiation exposure limits to both container stowaways and to its operators. The INEEL has fabricated custom-built, helium-3-based, neutron detectors for this inspection application and is performing an experimental application assessment. Because the Eagle Inspection system could not be moved to LANL where special nuclear material was available, the response of the Eagle had to be determined indirectly so as to support the development and testing of the detection system. Experiments in California have successfully matched the delayed neutron emission performance of the ARACOR Eagle with that of the transportable INEEL electron accelerator (i.e., the Varitron) and are reported here. A demonstration test is planned at LANL using the Varitron and shielded special nuclear materials within a cargo container. Detector results are providing very useful information regarding the challenges of delayed neutron counting near the photofission threshold energy of 5.5 - 6.0 MeV, are identifying the possible utilization of prompt neutron emissions to allow enhanced signal-to-noise measurements, and are showing the overall benefits of using higher electron beam energies.

  17. Development of sup 6 sup 0 Co cargo train inspection system

    CERN Document Server

    Wu Zhi Fang

    2002-01-01

    The author introduces the research and development of sup 6 sup 0 Co cargo train inspection system. With the use of radiography principle, every car image is acquired when the cargo train runs through the inspection channel. It is evaluated whether the cargo in car matches the corresponding customs declaration information with digital image processing techniques. The system has been installed in railway port at Manzhouli Customs

  18. Study on the multi-sensors monitoring and information fusion technology of dangerous cargo container

    Science.gov (United States)

    Xu, Shibo; Zhang, Shuhui; Cao, Wensheng

    2017-10-01

    In this paper, monitoring system of dangerous cargo container based on multi-sensors is presented. In order to improve monitoring accuracy, multi-sensors will be applied inside of dangerous cargo container. Multi-sensors information fusion solution of monitoring dangerous cargo container is put forward, and information pre-processing, the fusion algorithm of homogenous sensors and information fusion based on BP neural network are illustrated, applying multi-sensors in the field of container monitoring has some novelty.

  19. Solving the Liner Shipping Fleet Repositioning Problem with Cargo Flows

    DEFF Research Database (Denmark)

    Tierney, Kevin; Askelsdottir, Björg; Jensen, Rune Møller

    2015-01-01

    We solve a central problem in the liner shipping industry called the liner shipping fleet repositioning problem (LSFRP). The LSFRP poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between routes in a liner shipping network. Liner carriers wish...... introduce a novel mathematical model and a simulated annealing algorithm for the LSFRP with cargo flows that makes use of a carefully constructed graph; we evaluate these approaches using real-world data from our industrial collaborator. Additionally, we compare the performance of our approach against...... to solve the LSFRP....

  20. Optimization of the imported air express cargo distribution problem

    Directory of Open Access Journals (Sweden)

    Hwang, T.L.

    2013-03-01

    Full Text Available This study examines the delivering network of imported air express cargo as an integrated multi-depot vehicle routing problem. Integrated multi-depot vehicle routing problem attempts to decide which service centers should be used and how much freight should be unloaded in each service center. The role of an exchange point which is allowing the delivery vans and shuttles to exchange imported and exported goods is also addressed. Test results demonstrate the feasibility of the four models so these are highly promising for use in a diverse array of applications, such as in home delivery and reverse logistics.

  1. Analytical solution of the problem of acceleration of cargo by a bridge crane with constant acceleration at elimination of swings of a cargo rope

    Science.gov (United States)

    Korytov, M. S.; Shcherbakov, V. S.; Titenko, V. V.

    2018-01-01

    Limitation of the swing of the bridge crane cargo rope is a matter of urgency, as it can significantly improve the efficiency and safety of the work performed. In order to completely dampen the pendulum swing after the break-up of a bridge or a bridge-crane freight cart to maximum speed, it is necessary, in the normal repulsion control of the electric motor, to split the process of dispersion into a minimum of three gaps. For a dynamic system of swinging of a bridge crane on a flexible cable hanger in a separate vertical plane, an analytical solution was obtained to determine the temporal dependence of the cargo rope angle relative to the gravitational vertical when the cargo suspension point moves with constant acceleration. The resulting analytical dependence of the cargo rope angle and its first derivative can break the process of dispersing the cargo suspension point into three stages of dispersal and braking with various accelerations and enter maximum speed of movement of the cargo suspension point. In doing so, the condition of eliminating the swings of the cargo rope relative to the gravitational vertical is fulfilled. Provides examples of the maximum speed output constraints-to-time when removing the rope swing.

  2. Cooperating to Compete in the Global Air Cargo Industry: The Case of the DHL Express and Lufthansa Cargo A.G. Joint Venture Airline ‘AeroLogic’

    Directory of Open Access Journals (Sweden)

    Glenn Baxter

    2018-03-01

    Full Text Available This paper presents a case study of the DHL Express and Lufthansa Cargo strategic joint venture cargo airline ‘AeroLogic’, the global air cargo industry’s largest operative joint venture between an airline and a leading international express and logistics provider. The study used a qualitative research approach. The data gathered for the study was examined by document analysis. The strategic analysis of the AeroLogic joint venture was based on the use of Porter’s Five Forces framework. The study found that the AeroLogic joint venture airline has provided synergistic benefits to both partners and has allowed the partners to access new markets and to participate in the evolution of the air cargo industry. The new venture has also enabled both joint venture partners to enhance their competitive position in the global air cargo industry through strengthened service offerings and has provided the partners with increased cargo capacities, a larger route network, and greater frequencies within their own route networks. The study also found that the AeroLogic business model is unique in the air cargo industry. A limitation of the study was that AeroLogic’s annual revenue or freight traffic data was not available. It was, therefore, not possible to analyse the business performance of the joint venture.

  3. 77 FR 25187 - Extension of Agency Information Collection Activity Under OMB Review: Certified Cargo Screening...

    Science.gov (United States)

    2012-04-27

    ... and include facilties upstream ] in the air cargo supply chain, such as shippers, manufacturers, warehousing entities, distributors, third party logistics companies, and indirect air carriers located in the...

  4. Safety of Oversize Cargo in Ports and in the Sea Transport

    Directory of Open Access Journals (Sweden)

    Miroslaw Chmielinski

    2017-03-01

    Full Text Available Author of the paper analyzes problems related to the safety of the oversize cargo in ports and in the sea transport. Various modes of transport are used to carry oversized units that often include maritime transport. Transport of oversized cargo includes non-standard large and heavy pieces of cargo, such as electric transformers, reactor vessels, wind turbines, airplane fuselage or nuclear power plant components. The above paper is based on results of research oversized cargo in the Elpo Service Company and Pol-Mare Ltd. forwarding consulting agency.

  5. Report on the 2011 and 2012 NASA Ames Research Center (ARC) / Alaska State Cargo Airship Workshops

    Science.gov (United States)

    Hochstettler, Ronald

    2012-01-01

    This presentation will summarize the Cargo Airships for Northern Operations workshop that was held August 24-25, 2011. This workshop co-sponsored by NASA ARC and the Alaska State Department of Transportation was initiated by interest from Alaska Lt. Governor Mead Treadwell for assistance in investigating the potential benefits of proposed cargo airships for the Alaskan economy and societal needs. The workshop provided a brief background on the technology and operational aspects of conventional airships and hybrids followed by presentations on issues affecting cargo airship operations such as weather management, insurance, regulations, crew duty/rest rules, and available support infrastructures. Speakers representing potential cargo airship users from Alaskan State and commercial organizations presented the needs they felt could be met by cargo airship services. Presenters from Canadian private and military interests also detailed applications and missions that cargo airships could provide to remote regions of Canada. Cost drivers of cargo airship operations were also addressed and tools for modeling and analyzing operational factors and costs affecting cargo airship operations were discussed. Four breakout sessions were held which allowed workshop participants to contribute inputs to four topic areas: Business Approaches and Strategies (financing incentives public/private partnerships etc) for Airship Development and Operation, Design, Development, Production Challenges, and Possible Solutions, Regulatory, Certification, Legal, and Insurance Issues, and Operational Issues, Customer Requirements, and Airship Requirements. A follow on to the 2011 cargo airship workshop is being planned for July 31 August 2, 2012. A status update on this second workshop will also be presented.

  6. Cargo Loading and Unloading Efficiency Analysis in Multimodal Transport

    Directory of Open Access Journals (Sweden)

    Rafał Burdzik

    2014-08-01

    Full Text Available The paper presents assessment of the impact of the processes handling efficiency on the transport process based on research done in the real object, using same technologies and material handling equipment. The aim of the paper was to confirm importance of loading and unloading processes of palletized cargo as an initial and final link of multimodal transport by developing methods’ proposal for monitoring and assessing the effectiveness of cargo operations as well as development of measures and comparison estimators. The analysis of the manipulation operations’ duration throughout the transport process is based on the percentile rates of manipulation and carriage in total transport process duration and the percentage of manipulating time in the duration of the carriage. These indicators and examined loading and unloading times, are the basis for the development of scheduling algorithms for optimizing transport processes on the scale of the whole transport chain. This data is also a helpful input to support strategic decisions on the allocation of financial resources for the development of infrastructure and terminal equipment, warehouses and other facilities.

  7. A New Etiology for the Abdominal Compartment Syndrome: Pseudomyxoma Peritonei

    Directory of Open Access Journals (Sweden)

    Charles Sabbagh

    2015-09-01

    Full Text Available Pseudomyxoma peritonei (PMP is a rare diagnosis with an incidence of 1-2 per million. Most cases originate from an appendix which ruptures and releases mucin into the peritoneal cavity. The progression of the disease results in obstruction and cutaneous leak. Abdominal compartment syndrome is an uncommon complication of peritoneal pseudomyxoma. In the present article, we report the case of a patient with PMP and abdominal compartment syndrome. A laparotomy to decrease the abdominal pressure was performed. Three months later, a peritonectomy with hyperthermic intraperitoneal chemotherapy was performed. The patient was still alive 1 year after the procedure without any recurrence. In conclusion, acute abdominal pain and respiratory failure in patients with peritoneal PMP should lead to the measurement of the abdominal pressure but are not a contra indication for curative treatment of PMP.

  8. Air quality inside the passenger compartment of a bus.

    Science.gov (United States)

    Conceição, E Z; Silva, M C; Viegas, D X

    1997-01-01

    The indoor air quality in the passenger compartment of an intercity bus is studied. A system used for the remotion of the contaminants from the compartment, based on an extraction duct, was projected using a simple, unidimensional flow model with capability to predict the air exchange rate as a function of the vehicle velocity. Some tests using tracer gan methods were performed in a real vehicle with the contaminant remotion system mounted, in order to validate the calculation model and evaluate the performances of the system. A good agreement between the predicted and the experimental results was verified and the obtained air exchange rate was quite reasonable when compared with the former situation, without extraction duct.

  9. Bladder distension as a cause of abdominal compartment syndrome

    International Nuclear Information System (INIS)

    Yasir, M.; Hoda, M.Q.

    2018-01-01

    Abdominal compartment syndrome (ACS) is increasingly identified in critically ill patient and its harmful effects are well documented. The disparity among the pressure, volume in abdominal cavity and its contents, results in ACS. The actual incidence of ACS is not known. However, it has been observed predominantly in patients with severe blunt and penetrating abdominal trauma, ruptured abdominal aortic aneurysms, retro- and intra-peritoneal hemorrhage, pneumoperitoneum, neoplasm, pancreatitis, ascites and multiple bone fracture. We present a case of 40-year female who underwent emergency cesarean section and developed abdominal compartment syndrome due to urinary bladder distension secondary to blockade of urinary catheter with blood clots. This is a very unusual cause of ACS. (author)

  10. Filament-filament switching can be regulated by separation between filaments together with cargo motor number.

    Directory of Open Access Journals (Sweden)

    Robert P Erickson

    Full Text Available How intracellular transport controls the probability that cargos switch at intersections between filaments is not well understood. In one hypothesis some motors on the cargo attach to one filament while others attach to the intersecting filament, and the ensuing tug-of-war determines which filament is chosen. We investigate this hypothesis using 3D computer simulations, and discover that switching at intersections increases with the number of motors on the cargo, but is not strongly dependent on motor number when the filaments touch. Thus, simply controlling the number of active motors on the cargo cannot account for in vivo observations that found reduced switching with increasing motor number, suggesting additional mechanisms of regulation. We use simulations to show that one possible way to regulate switching is by simultaneously adjusting the separation between planes containing the crossing filaments and the total number of active motors on the cargo. Heretofore, the effect of filament-filament separation on switching has been unexplored. We find that the switching probability decreases with increasing filament separation. This effect is particularly strong for cargos with only a modest number of motors. As the filament separation increases past the maximum head-to-head distance of the motor, individual motors walking along a filament will be unable to reach the intersecting filament. Thus, any switching requires that other motors on the cargo attach to the intersecting filament and haul the cargo along it, while motor(s engaged on the original filament detach. Further, if the filament separation is large enough, the cargo can have difficulty proceeding along the initial filament because the engaged motors can walk underneath the intersecting filament, but the cargo itself cannot fit between the filaments. Thus, the cargo either detaches entirely from the original filament, or must dip to the side of the initial filament and then pass below

  11. Filament-filament switching can be regulated by separation between filaments together with cargo motor number.

    Science.gov (United States)

    Erickson, Robert P; Gross, Steven P; Yu, Clare C

    2013-01-01

    How intracellular transport controls the probability that cargos switch at intersections between filaments is not well understood. In one hypothesis some motors on the cargo attach to one filament while others attach to the intersecting filament, and the ensuing tug-of-war determines which filament is chosen. We investigate this hypothesis using 3D computer simulations, and discover that switching at intersections increases with the number of motors on the cargo, but is not strongly dependent on motor number when the filaments touch. Thus, simply controlling the number of active motors on the cargo cannot account for in vivo observations that found reduced switching with increasing motor number, suggesting additional mechanisms of regulation. We use simulations to show that one possible way to regulate switching is by simultaneously adjusting the separation between planes containing the crossing filaments and the total number of active motors on the cargo. Heretofore, the effect of filament-filament separation on switching has been unexplored. We find that the switching probability decreases with increasing filament separation. This effect is particularly strong for cargos with only a modest number of motors. As the filament separation increases past the maximum head-to-head distance of the motor, individual motors walking along a filament will be unable to reach the intersecting filament. Thus, any switching requires that other motors on the cargo attach to the intersecting filament and haul the cargo along it, while motor(s) engaged on the original filament detach. Further, if the filament separation is large enough, the cargo can have difficulty proceeding along the initial filament because the engaged motors can walk underneath the intersecting filament, but the cargo itself cannot fit between the filaments. Thus, the cargo either detaches entirely from the original filament, or must dip to the side of the initial filament and then pass below the crossing

  12. Compartment syndrome after total knee arthroplasty: regarding a clinical case

    Directory of Open Access Journals (Sweden)

    Ana Alexandra da Costa Pinheiro

    2015-08-01

    Full Text Available ABSTRACT Although compartment syndrome is a rare complication of total knee arthroplasty, it is one of the most devastating complications. It is defined as a situation of increased pressure within a closed osteofascial space that impairs the circulation and the functioning of the tissues inside this space, thereby leading to ischemia and tissue dysfunction. Here, a clinical case of a patient who was followed up in orthopedic outpatient consultations due to right gonarthrosis is presented. The patient had a history of arthroscopic meniscectomy and presented knee flexion of 10° before the operation, which consisted of total arthroplasty of the right knee. The operation seemed to be free from intercurrences, but the patient evolved with compartment syndrome of the ipsilateral leg after the operation. Since compartment syndrome is a true surgical emergency, early recognition and treatment of this condition through fasciotomy is crucial in order to avoid amputation, limb dysfunction, kidney failure and death. However, it may be difficult to make the diagnosis and cases may not be recognized if the cause of compartment syndrome is unusual or if the patient is under epidural analgesia and/or peripheral nerve block, which thus camouflages the main warning sign, i.e. disproportional pain. In addition, edema of the limb that underwent the intervention is common after total knee arthroplasty operations. This study presents a review of the literature and signals that the possible rarity of cases is probably due to failure to recognize this condition in a timely manner and to placing these patients in other diagnostic groups that are less likely, such as neuropraxia caused by using a tourniquet or peripheral nerve injury.

  13. Elimination behavior of shelter dogs housed in double compartment kennels.

    Directory of Open Access Journals (Sweden)

    Denae Wagner

    Full Text Available For animals in confinement housing the housing structure has tremendous potential to impact well being. Dogs in animal shelters are often housed in one of two types of confinement housing - single kennels and rooms or double compartment kennels and rooms most often separated by a guillotine door. This study examines the effect of housing on the location of elimination behavior in dogs housed in double compartment kennels were the majority of the dogs were walked daily. One side of the kennel contained the food, water and bed and the other side was empty and available except during cleaning time. Location of urination and defecation was observed daily for 579 dogs housed in indoor double compartment kennels for a total of 4440 days of observation. There were 1856 days (41.9% when no elimination was noted in the kennel. Feces, urine or both were observed in the kennel on 2584 days (58.1%. When elimination occurred in the kennel the probability of fecal elimination on the opposite side of the bed/food/water was 72.5% (95% CI 69.05% to 75.69%. The probability of urination on the opposite side of the bed/food/water was 77.4% (95% CI 74.33% to 80.07%. This study demonstrates the strong preference of dogs to eliminate away from the area where they eat, drink and sleep. Double compartment housing not only allows this - it allows staff the ability to provide safe, efficient, humane daily care and confers the added benefits of reducing risks for disease transmission for the individual dog as well as the population.

  14. Estimation of Water Footprint Compartments in National Wheat Production

    OpenAIRE

    B. Ababaei; H. Ramezani Etedali

    2016-01-01

    Introduction: Water use and pollution have raised to a critical level in many compartments of the world. If humankind is to meet the challenges over the coming fifty years, the agricultural share of water use has to be substantially reduced. In this study, a modern yet simple approach has been proposed through the introduction concept ‘Water Footprint’ (WF). This concept can be used to study the connection between each product and the water allocation to produce that product. This research es...

  15. Acute Compartment Syndrome of the Thigh in Combat Casualties

    Science.gov (United States)

    2013-03-01

    anesthesia (12); (c) internal hemorrhage or fluid extravasation such as coagulopathy and intramuscular hematoma (13, 14), false aneurysm (15), hamstring ...clinical signs and symptoms alone (27, 28). These signs include pain out of proportion, weakness and passive pain on stretch of the muscles in the...thigh. J. Orthop. Trauma 16:436–438, 2002. 6. Rooser, B., Bengtson, S., Hagglund, G. Acute compartment syndrome from anterior thigh muscle contusion: a

  16. Elimination behavior of shelter dogs housed in double compartment kennels.

    Science.gov (United States)

    Wagner, Denae; Newbury, Sandra; Kass, Philip; Hurley, Kate

    2014-01-01

    For animals in confinement housing the housing structure has tremendous potential to impact well being. Dogs in animal shelters are often housed in one of two types of confinement housing - single kennels and rooms or double compartment kennels and rooms most often separated by a guillotine door. This study examines the effect of housing on the location of elimination behavior in dogs housed in double compartment kennels were the majority of the dogs were walked daily. One side of the kennel contained the food, water and bed and the other side was empty and available except during cleaning time. Location of urination and defecation was observed daily for 579 dogs housed in indoor double compartment kennels for a total of 4440 days of observation. There were 1856 days (41.9%) when no elimination was noted in the kennel. Feces, urine or both were observed in the kennel on 2584 days (58.1%). When elimination occurred in the kennel the probability of fecal elimination on the opposite side of the bed/food/water was 72.5% (95% CI 69.05% to 75.69%). The probability of urination on the opposite side of the bed/food/water was 77.4% (95% CI 74.33% to 80.07%). This study demonstrates the strong preference of dogs to eliminate away from the area where they eat, drink and sleep. Double compartment housing not only allows this - it allows staff the ability to provide safe, efficient, humane daily care and confers the added benefits of reducing risks for disease transmission for the individual dog as well as the population.

  17. Compartment Syndrome Following Directly Repair of Hernia of Anterior Tibialis

    Directory of Open Access Journals (Sweden)

    Yuan-Ta Li

    2015-01-01

    Full Text Available We present a case of a patient with hernia of anterior tibialis who was treated operatively. Muscle herniation through a fascial defect is rare, which requires repair of fascial defects. We performed a simple closure of fascial defect. A fasciotomy was proceeded to complication of acute compartment syndrome developed after the operation. The sequelae as weakness of dorsiflexion of ankle and big toe were present.

  18. Infusoabdomen with abdominal compartment in extremely low birth weight neonates

    Directory of Open Access Journals (Sweden)

    Armin-Johannes Michel

    2016-03-01

    Full Text Available Central venous catheters (CVCs are frequently used in neonatal care. The rate of complications upon CVC use is high and the spectrum ranges from catheter tip dislocation to cardiac tamponade and death. Here we present an explanation model to the phenomenon of paravasate into human anatomical cavities based on two illustrative cases: Extremely low birth weight twins suffering from abdominal compartment syndromes due to different pathologies – one with a trans-peritoneal and one with intra-abdominal effusion. In both siblings the peripherally introduced central catheter (PICC perforated the vessel without clinical signs of bleeding and contributed to abdominal and thoracal complications. Case I (23 + 5 gestational week; 770 g; female showed clinical signs of an abdominal compartment syndrome without respective intestinal pathology upon open surgical procedure with ileostomy. Radiographic contrast examination showed retroperitoneal leakage when administered through the catheter. Replacement into the subclavian vein led to cardio-respiratory misbalance due to severe pleural effusion. Re-replacement finally led to clinical restitution after 60 days of intensive care. Case II (23 + 5 gestational week; 690 g; female showed clinical signs of an abdominal compartment syndrome, too. Radiographic contrast examination showed leakage from the PICC into the abdomen. Replacement of the PICC and invasive care led to improvement after 3 days. The 2 cases reveal that the displacement of a PICC can occur without direct clinical signs of hemodynamic imbalance i.e. bleeding or hematoma. Displacement of the catheter tip from intra-vascular, retro-peritoneal position can cause abdominal compartment syndromes either via trans-peritoneal migration of fluids or after perforation of the peritoneum via intra-abdominal administration of given infusion. Both options caused life threatening complications. Watchfulness and intensive surgical and non-surgical care are

  19. The statolith compartment in Chara rhizoids contains carbohydrate and protein

    Science.gov (United States)

    Wang-Cahill, F.; Kiss, J. Z.

    1995-01-01

    In contrast to higher plants, the alga Chara has rhizoids with single membrane-bound compartments that function as statoliths in gravity perception. Previous work has demonstrated that these statoliths contain barium sulfate crystals. In this study, we show that statoliths in Chara rhizoids react with a Coomassie Brilliant Blue cytochemical stain for proteins. While statoliths did not react with silver methenamine carbohydrate cytochemistry, the monoclonal antibody CCRC-M2, which is against a carbohydrate (sycamore-maple rhamnogalacturonan I), labeled the statolith compartment. These results demonstrate that in addition to barium sulfate, statoliths in Chara rhizoids have an organic matrix that consists of protein and carbohydrate moieties. Since the statoliths were silver methenamine negative, the carbohydrate in this compartment could be a 3-linked polysaccharide. CCRC-M2 also labeled Golgi cisternae, Golgi-associated vesicles, apical vesicles, and cell walls in the rhizoids. The specificity of CCRC-M2 immunolabeling was verified by several control experiments, including the demonstration that labeling was abolished when the antibody was preabsorbed with its antigen. Since in this and a previous study (John Z. Kiss and L. Andrew Staehelin, American Journal of Botany 80: 273-282, 1993) antibodies against higher plant carbohydrates crossreacted with cell walls of Chara in a specific manner, Characean algae may be a useful model system in biochemical and molecular studies of cell walls.

  20. Chronic Exertional Compartment Syndrome in a High School Soccer Player

    Directory of Open Access Journals (Sweden)

    James J. Bresnahan

    2015-01-01

    Full Text Available Chronic exertional compartment syndrome (CECS is a relatively rare condition that affects young adult athletes and often causes them to present to the emergency department. If left untreated, those who continue to compete at high levels may experience debilitating leg pain. Physicians may have difficulty differentiating CECS from other syndromes of the lower leg such as medial tibial stress syndrome, stress fractures, and popliteal artery entrapment. The gold standard for diagnosing CECS is intramuscular compartment pressure monitoring before and/or after 10 minutes of exercise. Some patients may choose to stop participation in sports in order to relieve their pain, which otherwise does not respond well to nonoperative treatments. In patients who wish to continue to participate in sports and live an active life, fasciotomy provides relief in 80% or more. The typical athlete can return to training in about 8 weeks. This is a case of a high school soccer player who stopped competing due to chronic exertional compartment syndrome. She had a fascial hernia, resting intramuscular pressure of 30 mmHg, and postexercise intramuscular pressure of 99 mmHg. Following fasciotomy she experienced considerable life improvement and is once again training and playing soccer without symptoms.

  1. Engineered protein nano-compartments for targeted enzyme localization.

    Directory of Open Access Journals (Sweden)

    Swati Choudhary

    Full Text Available Compartmentalized co-localization of enzymes and their substrates represents an attractive approach for multi-enzymatic synthesis in engineered cells and biocatalysis. Sequestration of enzymes and substrates would greatly increase reaction efficiency while also protecting engineered host cells from potentially toxic reaction intermediates. Several bacteria form protein-based polyhedral microcompartments which sequester functionally related enzymes and regulate their access to substrates and other small metabolites. Such bacterial microcompartments may be engineered into protein-based nano-bioreactors, provided that they can be assembled in a non-native host cell, and that heterologous enzymes and substrates can be targeted into the engineered compartments. Here, we report that recombinant expression of Salmonella enterica ethanolamine utilization (eut bacterial microcompartment shell proteins in E. coli results in the formation of polyhedral protein shells. Purified recombinant shells are morphologically similar to the native Eut microcompartments purified from S. enterica. Surprisingly, recombinant expression of only one of the shell proteins (EutS is sufficient and necessary for creating properly delimited compartments. Co-expression with EutS also facilitates the encapsulation of EGFP fused with a putative Eut shell-targeting signal sequence. We also demonstrate the functional localization of a heterologous enzyme (β-galactosidase targeted to the recombinant shells. Together our results provide proof-of-concept for the engineering of protein nano-compartments for biosynthesis and biocatalysis.

  2. Chronic Exertional Compartment Syndrome in a High School Soccer Player.

    Science.gov (United States)

    Bresnahan, James J; Hennrikus, William L

    2015-01-01

    Chronic exertional compartment syndrome (CECS) is a relatively rare condition that affects young adult athletes and often causes them to present to the emergency department. If left untreated, those who continue to compete at high levels may experience debilitating leg pain. Physicians may have difficulty differentiating CECS from other syndromes of the lower leg such as medial tibial stress syndrome, stress fractures, and popliteal artery entrapment. The gold standard for diagnosing CECS is intramuscular compartment pressure monitoring before and/or after 10 minutes of exercise. Some patients may choose to stop participation in sports in order to relieve their pain, which otherwise does not respond well to nonoperative treatments. In patients who wish to continue to participate in sports and live an active life, fasciotomy provides relief in 80% or more. The typical athlete can return to training in about 8 weeks. This is a case of a high school soccer player who stopped competing due to chronic exertional compartment syndrome. She had a fascial hernia, resting intramuscular pressure of 30 mmHg, and postexercise intramuscular pressure of 99 mmHg. Following fasciotomy she experienced considerable life improvement and is once again training and playing soccer without symptoms.

  3. Digital Microscopy Assessment of Angiogenesis in Different Breast Cancer Compartments

    Directory of Open Access Journals (Sweden)

    Anca Haisan

    2013-01-01

    Full Text Available Background/Aim. Tumour angiogenesis defined by microvessel density (MVD is generally accepted as a prognostic factor in breast cancer. However, due to variability of measurement systems and cutoffs, it is questionable to date whether it contributes to predictive outline. Our study aims to grade vascular heterogeneity by comparing clear-cut compartments: tumour associated stroma (TAS, tumour parenchyma, and tumour invasive front. Material and Methods. Computerized vessel area measurement was performed using a tissue cytometry system (TissueFAXS on slides originated from 50 patients with breast cancer. Vessels were marked using immunohistochemistry with CD34. Regions of interest were manually defined for each tumour compartment. Results. Tumour invasive front vascular endothelia area was 2.15 times higher than that in tumour parenchyma and 4.61 times higher than that in TAS (P<0.002. Worth to mention that the lymph node negative subgroup of patients show a slight but constant increase of vessel index in all examined compartments of breast tumour. Conclusion. Whole slide digital examination and region of interest (ROI analysis are a valuable tool in scoring angiogenesis markers and disclosing their prognostic capacity. Our study reveals compartments’ variability of vessel density inside the tumour and highlights the propensity of invasive front to associate an active process of angiogenesis with potential implications in adjuvant therapy.

  4. 75 FR 81 - Special Conditions: Boeing Model 787-8 Airplane; Overhead Flightcrew Rest Compartment Occupiable...

    Science.gov (United States)

    2010-01-04

    ... these regulations. The two OFCR compartment seats are only a couple of steps away from the stairway and... incapacitated person (representative of a ninety-fifth percentile male) from the OFCR compartment to the...

  5. Endocytosis of desmosomal plaques depends on intact actin filaments and leads to a nondegradative compartment

    DEFF Research Database (Denmark)

    Holm, Pernille K.; Hansen, Steen H.; Sandvig, Kirsten

    1993-01-01

    Cellebiologi, human epithelial cell line, growth inhibition, desmosomes, clathrin-independent endocytosis, cytoskeleton, nondegradative compartment......Cellebiologi, human epithelial cell line, growth inhibition, desmosomes, clathrin-independent endocytosis, cytoskeleton, nondegradative compartment...

  6. 46 CFR 32.60-15 - Segregation of cargo; Grade E-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Segregation of cargo; Grade E-TB/ALL. 32.60-15 Section 32.60-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT... § 32.60-15 Segregation of cargo; Grade E—TB/ALL. (a) General. The galleys, living quarters, navigation...

  7. 46 CFR 38.15-5 - Cargo hose-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo hose-TB/ALL. 38.15-5 Section 38.15-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS LIQUEFIED FLAMMABLE GASES Special Requirements § 38.15-5 Cargo hose—TB/ALL. (a) When the liquid and vapor line hoses used for loading and discharging...

  8. 19 CFR 192.14 - Electronic information for outward cargo required in advance of departure.

    Science.gov (United States)

    2010-04-01

    ... Information Through the Automated Export System (AES) § 192.14 Electronic information for outward cargo... or its authorized agent must use a CBP-approved electronic data interchange system (currently, the... authorized agents must electronically transmit and verify system acceptance of required cargo information for...

  9. 49 CFR 176.192 - Cargo handling equipment for freight containers carrying Class 1 (explosive) materials.

    Science.gov (United States)

    2010-10-01

    ...) Materials Handling Class 1 (explosive) Materials in Port § 176.192 Cargo handling equipment for freight containers carrying Class 1 (explosive) materials. (a) Except in an emergency, only cargo handling equipment... load, unload, or handle freight containers containing Division 1.1 or 1.2 (explosive) materials. (b...

  10. 46 CFR 308.551 - War risk insurance clearing agency agreement for cargo, Form MA-321.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false War risk insurance clearing agency agreement for cargo... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.551 War risk insurance... American War Risk Agency or MARAD. ...

  11. 76 FR 4709 - Extension of Agency Information Collection Activity Under OMB Review: Certified Cargo Screening...

    Science.gov (United States)

    2011-01-26

    ... off- airport and includes facilities upstream in the air cargo supply chain, such as shippers, manufacturers, warehousing entities, distributors, third party logistics companies, and Indirect Air Carriers... supply chain to accept, screen, and transport air cargo. The uninterrupted collection of this information...

  12. 76 FR 8658 - Bulk Solid Hazardous Materials: Harmonization With the International Maritime Solid Bulk Cargoes...

    Science.gov (United States)

    2011-02-15

    ... issues Special Permits as part of its mission to ensure maritime safety and facilitate U.S. commerce. To... Solid Hazardous Materials: Harmonization With the International Maritime Solid Bulk Cargoes (IMSBC) Code... International Convention for the Safety of Life at Sea (SOLAS), 1974, as amended, that carry bulk solid cargoes...

  13. CargoVibes: human response to vibration due to freight rail traffic

    NARCIS (Netherlands)

    Waddington, D.; Woodcock, J.; Smith, M.G.; Janssen, S.A.; Persson Waye, K.

    2015-01-01

    The aim of this paper is to present an overview of the research concerning human response to vibration conducted in the EU FP7 CargoVibes project. The European Union-funded project CargoVibes involved 10 partners from 8 nations and ran from April 2011 to April 2014. The project was concerned with

  14. On the question of the capacity of warehouses of packaged-piece cargoes

    Directory of Open Access Journals (Sweden)

    Ilesaliev D.I.

    2017-06-01

    Full Text Available Mathematical models are proposed that establish interrelations between the individual parameters of a warehouse of packaged piece cargo. The models were used in the study of the mutual influence of the parameters on each other, also the capacity of the warehouses of packaged cargo

  15. 46 CFR 153.515 - Special requirements for extremely flammable cargoes.

    Science.gov (United States)

    2010-10-01

    ... DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design... under pressure or that is submerged; and (c) The cargo tank's relief valve setting must be no less than 21 kPa gauge (approx. 3 psig). ...

  16. The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development

    NARCIS (Netherlands)

    Geiger, J.C.; Lipka, Joanna; Hoyer, S.; Schlager, M.A.; Wulf, Phebe; Weinges, S.; Demmers, J.; Hoogenraad, Casper

    2014-01-01

    Regulation of cargo transport via adaptor molecules is essential for neuronal development. However, the role of PDZ scaffolding proteins as adaptors in neuronal cargo trafficking is still poorly understood. Here, we show by genetic deletion in mice that the multi-PDZ domain scaffolding protein

  17. Molecular sleds comprising a positively -charged amino acid sequence and a molecular cargo and uses thereof

    NARCIS (Netherlands)

    Mangel, F Walter; Blainey, Paul C; Graziano, Vito; Herrmann, Andreas; McGrath, William J; van Oijen, Antonius Martinus; Xie, Xiaoliang Sunney

    2014-01-01

    The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the

  18. 46 CFR 154.709 - Cargo boil-off as fuel: Gas detection equipment.

    Science.gov (United States)

    2010-10-01

    ... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction and... percent by volume; and (ii) Closes the master gas fuel valve required under § 154.708(c) before the... amended by CGD 82-063b, 48 FR 4782, Feb. 3, 1983] Cargo Vent Systems ...

  19. 46 CFR 38.05-2 - Design and construction of cargo tanks-general-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Design and construction of cargo tanks-general-TB/ALL... FLAMMABLE GASES Design and Installation § 38.05-2 Design and construction of cargo tanks—general—TB/ALL. (a... tanks on barges shall be designed in accordance with § 32.63-25 of this subchapter. (f) Each liquefied...

  20. 49 CFR 178.320 - General requirements applicable to all DOT specification cargo tank motor vehicles.

    Science.gov (United States)

    2010-10-01

    ... MATERIALS REGULATIONS SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle... lading retention or containment function and provides no structural support to the cargo tank. Baffle.... Cargo tank means a bulk packaging that: (1) Is a tank intended primarily for the carriage of liquids...

  1. 75 FR 9915 - Extension of Agency Information Collection Activity Under OMB Review: Certified Cargo Screening...

    Science.gov (United States)

    2010-03-04

    ...-airport and includes facilties upstream in the air cargo supply chain, such as shippers, manufacturers...] Extension of Agency Information Collection Activity Under OMB Review: Certified Cargo Screening Program... Request (ICR), OMB control number 1652-0053, abstracted below to the Office of Management and Budget (OMB...

  2. 77 FR 6135 - Agency Information Collection Activities: Cargo Manifest/Declaration, Stow Plan, Container Status...

    Science.gov (United States)

    2012-02-07

    ... Activities: Cargo Manifest/ Declaration, Stow Plan, Container Status Messages and Importer Security Filing... the Paperwork Reduction Act: Cargo Manifest/Declaration, Stow Plan, Container Status Messages and.../Declaration, Stow Plan, Container Status Messages and Importer Security Filing. OMB Number: 1651-0001. Form...

  3. 76 FR 72715 - Agency Information Collection Activities: Cargo Manifest/Declaration, Stow Plan, Container Status...

    Science.gov (United States)

    2011-11-25

    ... Activities: Cargo Manifest/ Declaration, Stow Plan, Container Status Messages and Importer Security Filing... Manifest/Declaration, Stow Plan, Container Status Messages and Importer Security Filing. This request for... concerning the following information collection. Title: Cargo Manifest/Declaration, Stow Plan, Container...

  4. 77 FR 3487 - Agency Information Collection Activities: Transfer of Cargo to a Container Station

    Science.gov (United States)

    2012-01-24

    ... Activities: Transfer of Cargo to a Container Station AGENCY: U.S. Customs and Border Protection (CBP... requirement concerning Transfer of Cargo to a Container Station. This request for comment is being made... to a Container Station. OMB Number: 1651-0096. Form Number: None. Abstract: Before the filing of an...

  5. 33 CFR 126.29 - Supervision and control of dangerous cargo.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Supervision and control of... Supervision and control of dangerous cargo. (a) Authority. The Captain of the Port is authorized to require... cargo covered by this subchapter shall be undertaken and continued only under the immediate supervision...

  6. 49 CFR 175.26 - Notification at cargo facilities of hazardous materials requirements.

    Science.gov (United States)

    2010-10-01

    ... following information: (1) Cargo containing hazardous materials (dangerous goods) for transportation by... U.S.C. 5124). (3) Hazardous materials (dangerous goods) include explosives, compressed gases... 49 Transportation 2 2010-10-01 2010-10-01 false Notification at cargo facilities of hazardous...

  7. 29 CFR Appendix III to Part 1918 - The Mechanics of Conventional Cargo Gear (Non-mandatory)

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false The Mechanics of Conventional Cargo Gear (Non-mandatory.... 1918, App. III Appendix III to Part 1918—The Mechanics of Conventional Cargo Gear (Non-mandatory) Note: This appendix is non-mandatory and provides an explanation of the mechanics in the correct spotting of...

  8. Do cows prefer a barn compartment with a grooved or slotted floor

    NARCIS (Netherlands)

    Stefanowska, J.; Swierstra, D.; Berg, van den J.V.; Metz, J.H.M.

    2002-01-01

    Cow preferences for one of two compartments with different floors were tested in a barn with two symmetrical, connected compartments, each intended for 16 cows. Compartments were identical except for the floor. One floor was grooved longitudinally to the feeding barrier and the other was slotted

  9. Numerical Study on Hydrogen Flow Behavior in Two Compartments with Different Connecting Pipes

    Directory of Open Access Journals (Sweden)

    HanChen Liu

    2017-01-01

    Full Text Available Hydrogen accumulation in the containment compartments under severe accidents would result in high concentration, which could lead to hydrogen deflagration or detonation. Therefore, getting detailed hydrogen flow and distribution is a key issue to arrange hydrogen removal equipment in the containment compartments. In this study, hydrogen flow behavior in local compartments has been investigated in two horizontal compartments. The analysis model is built by 3-dimensional CFD code in Cartesian coordinates based on the connection structure of the Advanced Pressurized Water Reactor (PWR compartments. It consists of two cylindrical vessels, representing the Steam Generator compartment (SG and Core Makeup Tank compartment (CMT. With standard k-ε turbulence model, the effects of the connecting pipe size and location on hydrogen concentration distribution are investigated. Results show that increasing the diameter of connection pipe (IP which is located at 800 mm from 150 mm to 300 mm facilitates hydrogen flow between compartments. Decreasing the length of IP which is located at 800 mm from 1000 mm to 500 mm can also facilitate hydrogen flow between compartments. Lower IP is in favor of hydrogen mixing with air in non-source compartment. Higher IP is helpful for hydrogen flow to the non-source term compartment from source term compartment.

  10. CHARACTERISTICS OF THE CARGO INSURANCE CONTRACT IN CASE OF INTERNATIONAL LAND TRANSPORT

    Directory of Open Access Journals (Sweden)

    Dănilă Ștefan MATEI

    2017-05-01

    Full Text Available Cargo international transport is an engine for the development of the economic relations between states involving cross-border movement of goods through the crossing of at least one border of a state (international transport or by crossing at least two border crossing points, in which case we are in the presence of an international cargo transit. During the transit the goods transported may be subject to an insurance. The object of the cargo insurance is, thus, represented by the goods, the items expressly listed in the insurance policy, within the territorial limits specified in the insurance policy, both during the transport and during the storage, in the latter case, at the express request of the insured and with the acceptance of the insurer. This paper analyzes the characteristics of the cargo insurance aiming to present the theoretical and practical aspects of interest with regard to the cargo insurance concluded in case of an international land freight transport.

  11. Megavoltage cargo radiography with dual energy material decomposition

    Science.gov (United States)

    Shikhaliev, Polad M.

    2018-02-01

    Megavoltage (MV) radiography has important applications in imaging large cargos for detecting illicit materials. A useful feature of MV radiography is the possibility of decomposing and quantifying materials with different atomic numbers. This can be achieved by imaging cargo at two different X-ray energies, or dual energy (DE) radiography. The performance of both single energy and DE radiography depends on beam energy, beam filtration, radiation dose, object size, and object content. The purpose of this work was to perform comprehensive qualitative and quantitative investigations of the image quality in MV radiography depending on the above parameters. A digital phantom was designed including Fe background with thicknesses of 2cm, 6cm, and 18cm, and materials samples of Polyethylene, Fe, Pb, and U. The single energy images were generated at x-ray beam energies 3.5MV, 6MV, and 9MV. The DE material decomposed images were generated using interlaced low and high energy beams 3.5/6MV and 6/9MV. The X-ray beams were filtered by low-Z (Polyethylene) and high-Z (Pb) filters with variable thicknesses. The radiation output of the accelerator was kept constant for all beam energies. The image quality metrics was signal-to-noise ratio (SNR) of the particular sample over a particular background. It was found that the SNR depends on the above parameters in a complex way, but can be optimized by selecting a particular set of parameters. For some imaging setups increased filter thicknesses, while strongly absorbing the beams, increased the SNR of material decomposed images. Beam hardening due to polyenergetic x-ray spectra resulted in material decomposition errors, but this could be addressed using region of interest decomposition. It was shown that it is not feasible to separate the materials with close atomic numbers using the DE method. Particularly, Pb and U were difficult to decompose, at least at the dose levels allowed by radiation source and safety requirements.

  12. Identification Bracelet Precipitated Acute Compartment Syndrome during Intravenous Infusion in an Obtunded Patient

    Directory of Open Access Journals (Sweden)

    Wahib Zafar

    2016-01-01

    Full Text Available Acute compartment syndrome is a serious condition requiring immediate medical care. A lack of urgent medical treatment can result in serious complications such as loss of function and even amputation. While the pathophysiology of acute compartment syndrome is well understood, numerous potential causes are still being discovered. A rare cause of acute compartment syndrome is IV infiltration. We present a case of acute compartment syndrome resulting from intravenous infusion due to proximal placement of a patient identification bracelet. We conclude that both routine evaluation for IV infiltration and proximal placement of IV lines are essential for prevention of acute compartment syndrome.

  13. 46 CFR 154.530 - Valves: Cargo tank MARVS 69 kPa gauge (10 psig) or lower.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Valves: Cargo tank MARVS 69 kPa gauge (10 psig) or lower..., Construction and Equipment Cargo and Process Piping Systems § 154.530 Valves: Cargo tank MARVS 69 kPa gauge (10 psig) or lower. (a) Except those connections for tank safety relief valves and for liquid level gauging...

  14. 75 FR 63192 - Intent To Request Renewal From OMB of One Current Public Collection of Information: Air Cargo...

    Science.gov (United States)

    2010-10-14

    ... Commission Act of 2007, Public Law 110-53, Congress requires that 50 percent of cargo transported on... carriers transport cargo. TSA estimates this will take an estimated one hour per week (52 hours per year...] Intent To Request Renewal From OMB of One Current Public Collection of Information: Air Cargo Security...

  15. 46 CFR 154.1836 - Vapor venting as a means of cargo tank pressure and temperature control.

    Science.gov (United States)

    2010-10-01

    ... cargo pressure and temperature control system under §§ 154.701 through 154.709 is operating and that venting of cargo is unnecessary to maintain cargo temperature and pressure control, except under emergency... temperature control. 154.1836 Section 154.1836 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY...

  16. Compartment differences of inflammatory activity in chronic obstructive pulmonary disease.

    Science.gov (United States)

    Ji, Jie; von Schéele, Ida; Bergström, Jan; Billing, Bo; Dahlén, Barbro; Lantz, Ann-Sofie; Larsson, Kjell; Palmberg, Lena

    2014-08-26

    Chronic obstructive pulmonary disease (COPD) is associated with local and systemic inflammation. The knowledge of interaction and co-variation of the inflammatory responses in different compartments is meagre. Healthy controls (n = 23), smokers with (n = 28) and without (n = 29) COPD performed spirometry and dental examinations. Saliva, induced sputum, bronchoalveolar lavage (BAL) fluid and serum were collected. Inflammatory markers were assessed in all compartments using ELISA, flow cytometry and RT-PCR. Negative correlations between lung function and saliva IL-8 and matrix metalloproteinase-9 (MMP-9) were found in smokers with COPD. IL-8 and MMP-9 in saliva correlated positively with periodontal disease as assessed by gingival bleeding in non-smokers.Tumor necrosis factor-α (TNF-α) in saliva, serum and TNF-α mRNA expression on macrophages in BAL-fluid were lower in smokers than in non-smokers. There were positive correlations between soluble TNF-α receptor 1 (sTNFR1) and soluble TNF-α receptor 2 (sTNFR2) in sputum, BAL-fluid and serum in all groups. Sputum interleukin-8 (IL-8) or interleukin-6 (IL-6) was positively correlated with sTNFR1 or sTNFR2 in non-smokers and with sTNFR2 in COPD. Saliva which is convenient to collect and analyse, may be suitable for biomarker assessment of disease activity in COPD. An attenuated TNF-α expression was demonstrated by both protein and mRNA analyses in different compartments suggesting that TNF-α response is altered in moderate and severe COPD. Shedding of TNFR1 or TNFR2 is similarly regulated irrespective of airflow limitation.

  17. Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neuby human dendritic cells.

    Science.gov (United States)

    Baleeiro, Renato B; Rietscher, René; Diedrich, Andrea; Czaplewska, Justyna A; Lehr, Claus-Michael; Scherließ, Regina; Hanefeld, Andrea; Gottschaldt, Michael; Walden, Peter

    2015-11-01

    Cross-presentation is the process by which professional antigen presenting cells (APCs) (B cells, dendritic cells (DCs) and macrophages) present endocytosed antigens (Ags) via MHC-I to CD8 + T cells. This process is crucial for induction of adaptive immune responses against tumors and infected cells. The pathways and cellular compartments involved in cross-presentation are unresolved and controversial. Among the cells with cross-presenting capacity, DCs are the most efficient, which was proposed to depend on prevention of endosomal acidification to block degradation of the epitopes. Contrary to this view, we show in this report that some cargoes induce strong endosomal acidification following uptake by human DCs, while others not. Moreover, processing of the tumor-associated antigen HER2/ neu delivered in nanoparticles (NP) for cross-presentation of the epitope HER2/ neu 369-377 on HLA-A2 depended on endosomal acidification and cathepsin activity as well as proteasomes, and newly synthesized HLA class I. However, the HLA-A*0201/HER2/ neu 369-377 complexes were not found in the endoplasmic reticulum (ER) nor in endolysosomes but in hitherto not described vesicles. The data thus indicate spatial separation of antigen processing and loading of MHC-I for cross-presentation: antigen processing occurs in the uptake compartment and the cytosol whereas MHC-I loading with peptide takes place in a distinct subcellular compartment. The findings further elucidate the cellular pathways involved in the cross-presentation of a full-length, clinically relevant tumor-associated antigen by human DCs, and the impact of the vaccine formulation on antigen processing and CD8 + T cell induction.

  18. Congenital absence of superficial posterior compartment calf muscles.

    Science.gov (United States)

    Tibrewal, Saket; Alyas, Faisal; Vemulapalli, Krishna

    2014-06-01

    Although various congenital abnormalities have been described, congenital absence of calf musculature is extremely rare, with only one report on its complete absence. We are the first to describe a case of congenital absence of muscles of the superficial posterior compartment of the calf presenting in a toddler. The child presented with a history of a painless limp, however no significant difference was found in functional gait analysis. We suggest that such cases should be monitored and parents can be reassured that no immediate treatment is required.

  19. Modeling fires in adjacent ship compartments with computational fluid dynamics

    International Nuclear Information System (INIS)

    Wix, S.D.; Cole, J.K.; Koski, J.A.

    1998-01-01

    This paper presents an analysis of the thermal effects on radioactive (RAM) transportation packages with a fire in an adjacent compartment. An assumption for this analysis is that the adjacent hold fire is some sort of engine room fire. Computational fluid dynamics (CFD) analysis tools were used to perform the analysis in order to include convective heat transfer effects. The analysis results were compared to experimental data gathered in a series of tests on tile US Coast Guard ship Mayo Lykes located at Mobile, Alabama

  20. Recent advances in the management of abdominal compartment syndrome

    International Nuclear Information System (INIS)

    Saleem, T.B.; Ahmed, I.

    2004-01-01

    Abdominal compartment syndrome is a systemic syndrome involving derangement in cardiovascular hemodynamics, respiratory and renal function as a result of sustained increase in intra-abdominal pressure. This results in multi-organ failure requiring prompt action and treatment. Presentation can be acute, chronic and acute on chronic. Initial diagnosis is clinical, confirmed by measurement of urinary bladder pressure. Treatment is abdominal decompression by laparostomy and delayed abdominal closure. Awareness among the surgeons has increased because laparoscopy has resulted in determination of intra-abdominal pressure as a readily measurable quantity. They have been able to appreciate the benefit of abdominal decompression by performing repeated planned laparotomies for trauma. (author)

  1. The Golgi apparatus: roles for distinct 'cis' and 'trans' compartments.

    Science.gov (United States)

    Rothman, J E

    1982-01-01

    The Golgi apparatus seems to consist of distinct cis and trans compartments that are proposed to act sequentially to refine the protein export of the endoplasmic reticulum by removing escaped endoplasmic reticulum proteins. Refinement may be a multi-stage process that employs a principle akin to fractional distillation; the stack of cisternae comprising the cis Golgi may be the plates in this distillation tower. The trans Golgi, consisting of the last one or two cisternae, may be the receiver that collects from the cis Golgi only its most refined fraction for later distribution to specific locations throughout the cell.

  2. Cellular endocytic compartment localization of expressed canine CD1 molecules

    DEFF Research Database (Denmark)

    Schjærff, Mette; Keller, Stefan M.; Affolter, Verena K.

    2016-01-01

    CD1 molecules are glycoproteins present primarily on dendritic cells (DCs), which recognize and presenta variety of foreign- and self-lipid antigens to T-cells. Humans have five different CD1 isoforms that sur-vey distinct cellular compartments allowing for recognition of a large repertoire...... onlya diminished GFP expression. In conclusion, canine CD1 transfectants show distinct localization patternsthat are similar to human CD1 proteins with the exception of the canine CD1d isoform, which most likelyis non-functional. These findings imply that canine CD1 localization overall resembles human...

  3. The A/ENTH Domain-Containing Protein AtECA4 Is an Adaptor Protein Involved in Cargo Recycling from the trans-Golgi Network/Early Endosome to the Plasma Membrane.

    Science.gov (United States)

    Nguyen, Hong Hanh; Lee, Myoung Hui; Song, Kyungyoung; Ahn, Gyeongik; Lee, Jihyeong; Hwang, Inhwan

    2018-01-06

    Endocytosis and subsequent trafficking pathways are crucial for regulating the activity of plasma membrane-localized proteins. Depending on cellular and physiological conditions, the internalized cargoes are sorted at (and transported from) the trans-Golgi network/early endosome (TGN/EE) to the vacuole for degradation or recycled back to the plasma membrane. How this occurs at the molecular level remains largely elusive. Here, we provide evidence that the ENTH domain-containing protein AtECA4 plays a crucial role in recycling cargoes from the TGN/EE to the plasma membrane in Arabidopsis thaliana. AtECA4:sGFP primarily localized to the TGN/EE and plasma membrane (at low levels). Upon NaCl or mannitol treatment, AtECA4:sGFP accumulated at the TGN/EE at an early time point but was released from the TGN/EE to the cytosol at later time points. The ateca4 mutant showed higher resistance to osmotic stress and more sensitive to exogenous abscisic acid (ABA) than the wild type, as well as increased expression of ABA-inducible genes RD29A and RD29B. Consistently, ABCG25, a plasma membrane-localized ABA exporter, accumulated at the prevacuolar compartment in ateca4, indicating a defect in recycling to the plasma membrane. However, the role of AtECA4 in cargo recycling is not specific to ABCG25, as it also functions in the recycling of BRI1. These results suggest that AtECA4 plays a crucial role in the recycling of endocytosed cargoes from the TGN/EE to the plasma membrane. Copyright © 2018 The Author. Published by Elsevier Inc. All rights reserved.

  4. Systems Analysis and Structural Design of an Unpressurized Cargo Delivery Vehicle

    Science.gov (United States)

    Wu, K. Chauncey; Cruz, Jonathan N.; Antol, Jeffrey; Sasamoto, Washito A.

    2007-01-01

    The International Space Station will require a continuous supply of replacement parts for ongoing maintenance and repair after the planned retirement of the Space Shuttle in 2010. These parts are existing line-replaceable items collectively called Orbital Replacement Units, and include heavy and oversized items such as Control Moment Gyroscopes and stowed radiator arrays originally intended for delivery aboard the Space Shuttle. Current resupply spacecraft have limited to no capability to deliver these external logistics. In support of NASA's Exploration Systems Architecture Study, a team at Langley Research Center designed an Unpressurized Cargo Delivery Vehicle to deliver bulk cargo to the Space Station. The Unpressurized Cargo Delivery Vehicle was required to deliver at least 13,200 lbs of cargo mounted on at least 18 Flight Releasable Attachment Mechanisms. The Crew Launch Vehicle design recommended in the Exploration Systems Architecture Study would be used to launch one annual resupply flight to the International Space Station. The baseline vehicle design developed here has a cargo capacity of 16,000 lbs mounted on up to 20 Flight Releasable Attachment Mechanisms. Major vehicle components are a 5.5m-diameter cargo module containing two detachable cargo pallets with the payload, a Service Module to provide propulsion and power, and an aerodynamic nose cone. To reduce cost and risk, the Service Module is identical to the one used for the Crew Exploration Vehicle design.

  5. Gene expression analysis in the compartments of the murine uterus.

    Science.gov (United States)

    Rosario, Gracy Xavier; Cheng, Jr-Gang; Stewart, Colin L

    2016-01-01

    Embryo implantation, a key critical feature of mammalian pregnancy, involves co-ordinate interplay between an incoming blastocyst and a receptive uterus. Aberrations in signaling cascades during this process result in pregnancy loss in mammals, including women. Analysis of the complete uterus at any given point either during preparation for implantation or during and after embryo attachment and invasion makes it difficult to assign specific signaling mechanism to the individual cellular compartments of the uterus. Here, we describe methods for the specific isolation of the luminal epithelium (LE) and subsequent analysis of gene expression/signaling pathways during embryo attachment. We further describe the analysis of RNA and proteins by specific techniques of quantitative PCR (qPCR), immunostaining and Western blotting of uterine tissues. These methods can be applied to the other cellular compartments of the uterus and embryo invasion and endometrial development. These techniques will be beneficial to investigators for delineating the mechanisms involved during embryo attachment and female reproduction as well as providing a means to studying highly dynamic changes in gene expression in tissues. Copyright © 2015 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

  6. Involvement of the mitochondrial compartment in human NCL fibroblasts

    International Nuclear Information System (INIS)

    Pezzini, Francesco; Gismondi, Floriana; Tessa, Alessandra; Tonin, Paola; Carrozzo, Rosalba; Mole, Sara E.; Santorelli, Filippo M.; Simonati, Alessandro

    2011-01-01

    Highlights: ► Mitochondrial reticulum fragmentation occurs in human CLN1 and CLN6 fibroblasts. ► Likewise mitochondrial shift-to periphery and decreased mitochondrial density are seen. ► Enhanced caspase-mediated apoptosis occurs following STS treatment in CLN1 fibroblasts. -- Abstract: Neuronal ceroid lipofuscinosis (NCL) are a group of progressive neurodegenerative disorders of childhood, characterized by the endo-lysosomal storage of autofluorescent material. Impaired mitochondrial function is often associated with neurodegeneration, possibly related to the apoptotic cascade. In this study we investigated the possible effects of lysosomal accumulation on the mitochondrial compartment in the fibroblasts of two NCL forms, CLN1 and CLN6. Fragmented mitochondrial reticulum was observed in all cells by using the intravital fluorescent marker Mitotracker, mainly in the perinuclear region. This was also associated with intense signal from the lysosomal markers Lysotracker and LAMP2. Likewise, mitochondria appeared to be reduced in number and shifted to the cell periphery by electron microscopy; moreover the mitochondrial markers VDCA and COX IV were reduced following quantitative Western blot analysis. Whilst there was no evidence of increased cell death under basal condition, we observed a significant increase in apoptotic nuclei following Staurosporine treatment in CLN1 cells only. In conclusion, the mitochondrial compartment is affected in NCL fibroblasts invitro, and CLN1 cells seem to be more vulnerable to the negative effects of stressed mitochondrial membrane than CLN6 cells.

  7. Identifiability Results for Several Classes of Linear Compartment Models.

    Science.gov (United States)

    Meshkat, Nicolette; Sullivant, Seth; Eisenberg, Marisa

    2015-08-01

    Identifiability concerns finding which unknown parameters of a model can be estimated, uniquely or otherwise, from given input-output data. If some subset of the parameters of a model cannot be determined given input-output data, then we say the model is unidentifiable. In this work, we study linear compartment models, which are a class of biological models commonly used in pharmacokinetics, physiology, and ecology. In past work, we used commutative algebra and graph theory to identify a class of linear compartment models that we call identifiable cycle models, which are unidentifiable but have the simplest possible identifiable functions (so-called monomial cycles). Here we show how to modify identifiable cycle models by adding inputs, adding outputs, or removing leaks, in such a way that we obtain an identifiable model. We also prove a constructive result on how to combine identifiable models, each corresponding to strongly connected graphs, into a larger identifiable model. We apply these theoretical results to several real-world biological models from physiology, cell biology, and ecology.

  8. Delayed Presentation of Gluteal Compartment Syndrome: The Argument for Fasciotomy

    Directory of Open Access Journals (Sweden)

    John E. Lawrence

    2016-01-01

    Full Text Available A male patient in his fifties presented to his local hospital with numbness and weakness of the right leg which left him unable to mobilise. He reported injecting heroin the previous morning. Following an initial diagnosis of acute limb ischaemia the patient was transferred to a tertiary centre where Computed Tomography Angiography was reported as normal. Detailed neurological examination revealed weakness in hip flexion and extension (1/5 on the Medical Research Council scale with complete paralysis of muscle groups distal to this. Sensation to pinprick and light touch was globally reduced. Blood tests revealed acute kidney injury with raised creatinine kinase and the patient was treated for rhabdomyolysis. Orthopaedic referral was made the following day and a diagnosis of gluteal compartment syndrome (GCS was made. Emergency fasciotomy was performed 56 hours after the onset of symptoms. There was immediate neurological improvement following decompression and the patient was rehabilitated with complete nerve recovery and function at eight-week follow-up. This is the first documented case of full functional recovery following a delayed presentation of GCS with sciatic nerve palsy. We discuss the arguments for and against fasciotomy in cases of compartment syndrome with significant delay in presentation or diagnosis.

  9. Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments.

    Science.gov (United States)

    Correia, Maria S; Moreiras, Hugo; Pereira, Francisco J C; Neto, Matilde V; Festas, Tiago C; Tarafder, Abul K; Ramalho, José S; Seabra, Miguel C; Barral, Duarte C

    2018-03-01

    Melanin transfer from melanocytes to keratinocytes and subsequent accumulation in the supranuclear region is a critical process in skin pigmentation and protection against UVR. We have previously proposed that the main mode of transfer between melanocytes and keratinocytes is through exo/endocytosis of the melanosome core, termed melanocore. In this study, we developed an in vitro uptake assay using melanocores secreted by melanocytes. We show that the uptake of melanocores, but not melanosomes, by keratinocytes is protease-activated receptor-2-dependent. Furthermore, we found that the silencing of the early endocytic regulator Rab5b, but not the late endocytic regulators Rab7a or Rab9a, significantly impairs melanocore uptake by keratinocytes. After uptake, we observed that melanin accumulates in compartments that are positive for both early and late endocytic markers. We found that melanin does not localize to either highly degradative or acidic organelles, as assessed by LysoTracker and DQ-BSA staining, despite the abundance of these types of organelles within keratinocytes. Therefore, we propose that melanocore uptake leads to storage of melanin within keratinocytes in hybrid endocytic compartments that are not highly acidic or degradative. By avoiding lysosomal degradation, these specialized endosomes may allow melanin to persist within keratinocytes for long periods. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Atraumatic medial collateral ligament oedema in medial compartment knee osteoarthritis

    International Nuclear Information System (INIS)

    Bergin, D.; Keogh, C.; O'Connell, M.; Zoga, A.; Rowe, D.; Shah, B.; Eustace, S.

    2002-01-01

    Objective: To describe and determine the prevalence of atraumatic medial collateral oedema identified in patients with medial compartment osteoarthritis. Design and patients: Sixty patients, 30 patients with medial compartment knee osteoarthritis (Kellgren and Lawrence grade 2 to 4) and 30 age-matched patients with atraumatic knee pain without osteoarthritis, referred for MR imaging over a 2 year period were included in the study. In each case, severity of osteoarthritis was recorded on radiographs and correlated with the presence or absence of medial collateral ligament oedema at MR imaging. Results: Medial collateral oedema was identified in 27 of the 30 patients with osteoarthritis, of whom 14 had grade 1 oedema and 13 had grade 2 oedema compared with the presence of medial collateral ligament oedema (grade 1) in only two of the 30 control patients without osteoarthritis (P<<0.0001). Conclusion: Medial collateral oedema is common in patients with osteoarthritis in the absence of trauma. When identified, medial collateral ligament oedema should be considered to be a feature of osteoarthritis and should not be incorrectly attributed to an acute traumatic injury. (orig.)

  11. Bogota Bag in Abdominal Compartment Syndrome at Kathmandu Model Hospital.

    Science.gov (United States)

    Joshi, Bijendra Dhoj; Koirala, Udaya; Upadhyaya, Amit M; Joshi, Arbin; Dhital, Saroj

    2017-09-08

    The gold standard of quick and definitive treatment of Abdominal compartment syndrome (ACS) is surgical decompression by opening the abdomen and leaving it open until intra-abdominal pressure decreases. Temporary abdominal closure techniques are used to postpone definite closure until predisposing factors causing pathologic elevation of intra-abdominal pressure are resolved.This study aim to analyze feasibility of Bogota Bag placement as a way of temporary abdominal closure. Cases admitted in the period of eight years that were diagnosed to have or at risk to develop ACS and managed with 'Bogota Bag', irrespective of primary diagnosis were reviewed retrospectively. Cause of ACS, reasons to place Bogota bag, its complications and final outcome in terms of mortality related or not related with Bogota Bag placement were assessed. Total of ten patients had placement of Bogota Bag in the period of eight years. Laparotomy for bowel perforation with peritonitis was the most common primary condition contributing to ACS. Bogota bag was placed in two cases after emergency decompression as a therapeutic measure whereas others were done as prophylactic measure. There were two mortalities (20%) which were not directly related to abdominal compartment syndrome. Abdomen closure with Bogota Bag for patients with ACS or likely to develop ACS is a feasible technique with minimal procedure related morbidities.

  12. A multiple-compartment model for biokinetics studies in plants

    International Nuclear Information System (INIS)

    Garcia, Fermin; Pietrobron, Flavio; Fonseca, Agnes M.F.; Mol, Anderson W.; Rodriguez, Oscar; Guzman, Fernando

    2001-01-01

    In the present work is used the system of linear equations based in the general Assimakopoulos's GMCM model , for the development of a new method that will determine the flow's parameters and transfer coefficients in plants. The need of mathematical models to quantify the penetration of a trace substance in animals and plants, has often been stressed in the literature. Usually, in radiological environment studies, it is used the mean value of contaminant concentrations on whole or edible part plant body, without taking in account vegetable physiology regularities. In this work concepts and mathematical formulation of a Vegetable Multi-compartment Model (VMCM), taking into account the plant's physiology regularities is presented. The model based in general ideas of the GMCM , and statistical Square Minimum Method STATFLUX is proposed to use in inverse sense: the experimental time dependence of concentration in each compartment, should be input, and the parameters should be determined from this data in a statistical approach. The case of Uranium metabolism is discussed. (author)

  13. Compartment Syndrome as a Result of Systemic Capillary Leak Syndrome

    Directory of Open Access Journals (Sweden)

    Kwadwo Kyeremanteng

    2016-01-01

    Full Text Available Objective. To describe a single case of Systemic Capillary Leak Syndrome (SCLS with a rare complication of compartment syndrome. Patient. Our patient is a 57-year-old male, referred to our hospital due to polycythemia (hemoglobin (Hgb of 220 g/L, hypotension, acute renal failure, and bilateral calf pain. Measurements and Main Results. The patient required bilateral forearm, thigh, and calf fasciotomies during his ICU stay and continuous renal replacement therapy was instituted following onset of acute renal failure and oliguria. Ongoing hemodynamic (Norepinephrine and Milrinone infusion and respiratory (ventilator support in the ICU was provided until resolution of intravascular fluid extravasation. Conclusions. SCLS is an extremely rare disorder characterized by unexplained episodic capillary hyperpermeability, which causes shift of volume and protein from the intravascular space to the interstitial space. Patients present with significant hypotension, hemoconcentration, hypovolemia, and oliguria. Severe edema results from leakage of fluid and proteins into tissue. The most important part of treatment is maintaining stable hemodynamics, ruling out other causes of shock and diligent monitoring for complications. Awareness of the clinical syndrome with the rare complication of compartment syndrome may help guide investigations and diagnoses of these critically ill patients.

  14. DNA hairpins promote temperature controlled cargo encapsulation in a truncated octahedral nanocage structure family

    DEFF Research Database (Denmark)

    Franch, Oskar; Iacovelli, Federico; Falconi, Mattia

    2016-01-01

    In the present study we investigate the mechanism behind temperature controlled cargo uptake using a truncated octahedral DNA cage scaffold functionalized with one, two, three or four hairpin forming DNA strands inserted in one corner of the structure. This investigation was inspired by our...... previous demonstration of temperature controlled reversible encapsulation of the cargo enzyme, horseradish peroxidase, in the cage with four hairpin forming strands. However, in this previous study the mechanism of cargo uptake was not directly addressed (Juul, et al., Temperature-Controlled Encapsulation...

  15. Scientific opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils

    DEFF Research Database (Denmark)

    Petersen, Annette

    Shipping of edible fats and oils into Europe is permitted in bulk tanks, provided that the previous cargo is included in a positive list. The European Commission requested EFSA to evaluate the acceptability as previous cargoes for fats and oils the substances calcium lignosulphonate, methyl acetate......, ethyl tert-butyl ether (ETBE) and ammonium sulphate. The evaluation was based on the same criteria as those used for the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils. Methyl acetate and ETBE meet...

  16. Estimation of adipose compartment volumes in CT images of a mastectomy specimen

    Science.gov (United States)

    Imran, Abdullah-Al-Zubaer; Pokrajac, David D.; Maidment, Andrew D. A.; Bakic, Predrag R.

    2016-03-01

    Anthropomorphic software breast phantoms have been utilized for preclinical quantitative validation of breast imaging systems. Efficacy of the simulation-based validation depends on the realism of phantom images. Anatomical measurements of the breast tissue, such as the size and distribution of adipose compartments or the thickness of Cooper's ligaments, are essential for the realistic simulation of breast anatomy. Such measurements are, however, not readily available in the literature. In this study, we assessed the statistics of adipose compartments as visualized in CT images of a total mastectomy specimen. The specimen was preserved in formalin, and imaged using a standard body CT protocol and high X-ray dose. A human operator manually segmented adipose compartments in reconstructed CT images using ITK-SNAP software, and calculated the volume of each compartment. In addition, the time needed for the manual segmentation and the operator's confidence were recorded. The average volume, standard deviation, and the probability distribution of compartment volumes were estimated from 205 segmented adipose compartments. We also estimated the potential correlation between the segmentation time, operator's confidence, and compartment volume. The statistical tests indicated that the estimated compartment volumes do not follow the normal distribution. The compartment volumes are found to be correlated with the segmentation time; no significant correlation between the volume and the operator confidence. The performed study is limited by the mastectomy specimen position. The analysis of compartment volumes will better inform development of more realistic breast anatomy simulation.

  17. Mixing of radiolytic hydrogen generated within a containment compartment following a LOCA

    International Nuclear Information System (INIS)

    Willcutt, G.J.E. Jr.; Gido, R.G.

    1978-07-01

    The objective of this work was to determine hydrogen concentration variations with position and time in a closed containment compartment with radiolytic hydrogen generation in the water on the compartment floor following a Loss-of-Coolant-Accident (LOCA). One application is to determine the potential difference between the compartment maximum hydrogen concentration and a hydrogen detector reading, due to the detector location. Three possible mechanisms for hydrogen transport in the compartment were investigated: (1) molecular diffusion, (2) possible bubble formation and motion, and (3) natural convection flows. A base case cubic compartment with 6.55-m (21.5-ft) height was analyzed. Parameter studies were used to determine the sensitivity of results to compartment size, hydrogen generation rates, diffusion coefficients, and the temperature difference between the floor and the ceiling and walls of the compartment. Diffusion modeling indicates that if no other mixing mechanism is present for the base case, the maximum hydrogen volume percent (vol percent) concentration difference between the compartment floor and ceiling will be 4.8 percent. It will be 24.5 days before the maximum concentration difference is less than 0.5 percent. Bubbles do not appear to be a potential source of hydrogen pocketing in a containment compartment. Compartment natural convection circulation rates for a 2.8 K (5 0 F) temperature difference between the floor and the ceiling and walls are estimated to be at least the equivalent of 1 compartment volume per hour and probably in the range of 4 to 9 compartment volumes per hour. Related natural convection studies indicate there will be turbulent mixing in the compartment for a 2.8 K (5 0 F) temperature difference between the floor and the ceiling and walls

  18. Estimation of Water Footprint Compartments in National Wheat Production

    Directory of Open Access Journals (Sweden)

    B. Ababaei

    2016-09-01

    Full Text Available Introduction: Water use and pollution have raised to a critical level in many compartments of the world. If humankind is to meet the challenges over the coming fifty years, the agricultural share of water use has to be substantially reduced. In this study, a modern yet simple approach has been proposed through the introduction concept ‘Water Footprint’ (WF. This concept can be used to study the connection between each product and the water allocation to produce that product. This research estimates the green, blue and gray WF of wheat in Iran. Also a new WF compartment (white is used that is related about irrigation water loss. Materials and Methods: The national green (Effective precipitation, blue (Net irrigation requirement, gray (For diluting chemical fertilizers and white (Irrigation water losses water footprints (WF of wheat production were estimated for fifteen major wheat producing provinces of Iran. Evapotranspiration, irrigation requirement, gross irrigation requirement and effective rainfall were got using the AGWAT model. Yields of irrigated and rain-fed lands of each province were got from Iran Agricultural-Jihad Ministry. Another compartment of the wheat production WF is related about the volume of water required to assimilate the fertilizers leached in runoff (gray WF. Moreover, a new concept of white water footprint was proposed here and represents irrigation water losses, which was neglected in the original calculation framework. Finally, the national WF compartments of wheat production were estimated by taking the average of each compartment over all the provinces weighted by the share of each province in total wheat production of the selected provinces. Results and Discussion: In 2006-2012, more than 67% of the national wheat production was irrigated and 32.3% were rain-fed, on average, while 37.9% of the total wheat-cultivated lands were irrigated and 62.1% was rain-fed from more than 6,568 -ha. The total national WF of

  19. Simulation for assessment of bulk cargo berths number

    Science.gov (United States)

    Kuznetsov, A. L.; Kirichenko, A. V.; Slitsan, A. E.

    2017-10-01

    The world trade volumes of mineral resources have been growing constantly for decades, notwithstanding any economical crises. At the same time, the proximity of the bulk materials as products to the starting point of the integrated value added or logistic supply chain makes their unit price relatively low. This fact automatically causes a strong economic sensitivity of the supply chain to the level of operational expenses in every link. The core of the integrated logistic supply chain is its maritime segment, with the fleet and terminals (i.e. the cargo transportation system) serving as the base platform for it. In its turn, the terminal berths play a role of the interface between the fleet and the land-transportation sub-system. Current development of the maritime transportation technologies, ships and terminal specialization, vessel size growth, rationalization of route patterns, regionalization of trade etc., has made conventional calculation methods inadequate. The solution of the problem is in using object oriented simulation. At the same time, this approch usually assumes only ad hoc models. Thus, it does not provide the generality of its conventional analytical predecessors. The time and labor consumpting procedure of simulation results in a very narrow application domain of the model. This article describes a new simulation instrument, combining the generality of the analytical technoques with the efficiency of the object-oriented simulation. The approach implemented as a software module, which validity and adequacy are proved. The software was tested on several sea terminal design projects and confirmed its efficiency.

  20. Multi-compartment iodine calculations with FIPLOC/IMPAIR

    International Nuclear Information System (INIS)

    Ewig, F.; Allelein, H.J.; Schwarz, S.; Weber, G.

    1996-01-01

    The multi-compartment containment code FIPLOC for the simulation of severe accidents in LWR plants was extended by the integration of the iodine model IMPAIR-3. The iodine model which originally was only drafted for chains of compartments was changed for arbitrary compartment configurations and tightly coupled to the thermal hydraulic part. A main progress with the coupled version FIPLOC-3.0 is the sophisticated modelling of the aerosol iodine behaviour. In a PWR accident the mass of iodine is mainly released in form of CsI aerosol from the primary circuit. In IMPAIR-3 the aerosol behaviour of the species CsI, AgI and IO 3 - is modelled in a very simplified way causing large uncertainties in the calculated distributions. The behaviour of these three aerosol species is treated by the aerosol model MAEROS/MGA. Agglomeration, particle growth by condensation and all deposition processes are calculated. The solubility effect for the hygroscopic species CsI and IO 3 - are comprehended. Furthermore the impact of the iodine decay heat on the thermal hydraulic behaviour is considered. In order to test the code development a preliminary FIPLOC-3.0 calculation was done simulating a German PWR containment for the core melt scenario ND* according to the German risk study phase B. IN the calculation a contact of the core melt with the sump water was assumed and the containment vent line was opened after 70 hours. The result show that the different iodine species are distributed inhomogeneously within the containment. The CsI-aerosol concentrations differ by two orders of magnitude and the I 2 -concentration even by three orders of magnitude. Most of the iodine is assumed to be released as CsI aerosol out of the primary circuit. Since it fastly deposits its contribution to the release into the environment is minor. CsI is however dissolved in the sump, where mainly the gaseous I 2 is created which can react in the containment atmosphere to IO 3 - . (author) 11 figs., 3 tabs., 12

  1. Pediatric Nonfracture Acute Compartment Syndrome: A Review of 39 Cases.

    Science.gov (United States)

    Livingston, Kristin; Glotzbecker, Michael; Miller, Patricia E; Hresko, Michael T; Hedequist, Daniel; Shore, Benjamin J

    2016-01-01

    Compartment syndrome in the absence of fracture is rare and poorly described within the pediatric literature. The purpose of this study was to report the varying etiologies, risk factors, and treatment outcomes associated with pediatric nonfracture acute compartment syndrome (NFACS). We conducted a retrospective chart review on 37 children who suffered a NFACS and were treated at a single pediatric trauma center between 1997 and 2013. Demographic, diagnostic, treatment, and outcome characteristics were reviewed. Five causal groups were generated: trauma, exercise related (acute presentation after exercise without trauma), infectious, vascular, and postoperative (in the absence of osteotomy). Univariate and multivariate analyses were performed to identify risk factors of NFACS. P-values 39 cases of NFRCS in 37 children [6 females, 31 males, mean age of 11.7 y (SD+7.2 y)]. The leg was the most commonly involved limb (29 cases, 74%). Diagnosis of NFRCS was made either by compartment pressure monitoring [59%, 23/39 cases, mean pressure 66 mm Hg (SD+28)] or by clinical examination. According to etiology, vascular was most common (11/39, 28%), followed by trauma (10/39, 26%) and postoperative (8/39, 21%), with exertion and infection representing a small proportion (6/39, 15% and 4/39, 10%, respectively). Pain was present in 33 cases (85%), swelling in 28 cases (72%), paresthesias in 13 cases (33%), motor deficit in 12 cases (31%), and poor perfusion in 11 cases (28%). Average time from symptom onset to diagnosis was 48 hours (IQR, 9 to 96 h). At surgery, 21 patients (54%) had evidence of myonecrosis. Children required an average of 3 surgeries for wound closure. The median time to follow-up was 232 days (IQR, 73 to 608 d). A total of 54% made a full recovery, whereas 31% suffered a persistent neurological or functional deficit. NFACS in children is associated with a delay in diagnosis and a high rate of myonecrosis. Timely assessment with high clinical suspicion is

  2. Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity

    NARCIS (Netherlands)

    Kevenaar, Josta T|info:eu-repo/dai/nl/338771042; Bianchi, Sarah; van Spronsen, Myrrhe|info:eu-repo/dai/nl/337616655; Olieric, Natacha; Lipka, Joanna|info:eu-repo/dai/nl/369403142; Frias, Cátia P; Mikhaylova, Marina; Harterink, Martin|info:eu-repo/dai/nl/304075655; Keijzer, Nanda; Wulf, Phebe S; Hilbert, Manuel; Kapitein, Lukas C|info:eu-repo/dai/nl/298806630; de Graaff, Esther|info:eu-repo/dai/nl/148374646; Akhmanova, Anna|info:eu-repo/dai/nl/156410591; Steinmetz, Michel O; Hoogenraad, Casper C|info:eu-repo/dai/nl/227263502

    2016-01-01

    Kinesin motor proteins play a fundamental role for normal neuronal development by controlling intracellular cargo transport and microtubule (MT) cytoskeleton organization. Regulating kinesin activity is important to ensure their proper functioning, and their misregulation often leads to severe human

  3. 33 CFR 149.130 - What are the requirements for the cargo transfer system alarm?

    Science.gov (United States)

    2010-07-01

    ... EQUIPMENT Pollution Prevention Equipment § 149.130 What are the requirements for the cargo transfer system... system. (b) The alarm must sound automatically in the control room and: (1) Be capable of being activated...

  4. International air cargo operations and gateways : their emerging importance to the state of Texas.

    Science.gov (United States)

    2011-07-01

    Air cargo transport has become particularly important in todays expanding global : economy for the movement of high-value goods such as electronics, computer components, : precision equipment, medical supplies, auto parts, and perishables. Air car...

  5. Matrix-dependent local retention of secretory vesicle cargo in cortical neurons

    NARCIS (Netherlands)

    de Wit, J.; Toonen, R.F.G.; Verhage, M.

    2009-01-01

    Neurons secrete many diffusible signals from synaptic and other secretory vesicles. We characterized secretion of guidance cues, neuropeptides, neurotrophins, and proteases from single secretory vesicles using pHluorin-tagged cargo in cortical neurons. Stimulation triggered transient and persistent

  6. 46 CFR 154.1710 - Exclusion of air from cargo tank vapor spaces.

    Science.gov (United States)

    2010-10-01

    ... is loaded by maintaining a positive pressure of at least 13.8 kPa gauge (2 psig) by: (1) Introducing... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Special Design and...

  7. Opportunity of Constructing a Cargo Terminal – Case Study Brașov International Airport, Romania

    Directory of Open Access Journals (Sweden)

    Gabriel BRĂTUCU

    2017-02-01

    Full Text Available Air transport and especially air cargo transport became ever more important during the last 25 years, with a signifi cant impact upon economic development. Air cargo transport supports regional economic development, provided there is suffi cient local demand for its services. In our study, we have identifi ed signifi cant elements of the impact a cargo terminal at the International Brașov-Ghimbav Airport would have upon local economic development. For this purpose, we have conducted a quantitative market research. We have reached the conclusion that constructing a cargo terminal at the Brașov-Ghimbav Airport is a necessary investment in the current economic context, with an important contribution to the economic development of its surrounding counties. The positive results registered in our study could contribute to improving the economic and fi nancial prospects of Brașov-Ghimbav Airport and attract investors in this project.

  8. Idiopathic Acute Isolated Lateral Compartment Syndrome of a Lower Leg: A Magnetic Resonance Imaging Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Yeom, Dong Heon; Lee, Ji Hae; Cho, Woo Ho; Kim, Jae Hyung; Jeong, Myeong Ja; Kim, Soung Hee; Kim, Ji Young; Kim, Soo Hyun; Kang, Mi Jin; Lee, Han Bee [Dept. of Radiology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Bae, Kyung Eun [Dept. of Radiology, Seoul Asan Hospital, Ulsan University College of Medicine, Seoul (Korea, Republic of)

    2013-01-15

    Acute compartment syndrome of the lower leg is usually associated with major trauma such as fracture, and most commonly occurs in the anterior or deep posterior compartments. Isolated lateral compartment syndrome is less typical and usually associated with minor trauma or exertion. There are a few reports of the acute compartment syndrome which develops without an obvious cause. However, there are few reports of idiopathic acute isolated lateral compartment syndrome, and there are no reports of the radiologic findings. This study presents a radiologic finding of idiopathic acute isolated lateral compartment of lower leg, which shows localized enlargement of the peroneal muscles with peripheral convex bowing and change of their signal intensity with fluid signal along the adjacent fascial planes on magnetic resonance imaging.

  9. The anammoxosome: an intracytoplasmic compartment in anammox bacteria.

    Science.gov (United States)

    van Niftrik, Laura A; Fuerst, John A; Sinninghe Damsté, Jaap S; Kuenen, J Gijs; Jetten, Mike S M; Strous, Marc

    2004-04-01

    Anammox bacteria belong to the phylum Planctomycetes and perform anaerobic ammonium oxidation (anammox); they oxidize ammonium with nitrite as the electron acceptor to yield dinitrogen gas. The anammox reaction takes place inside the anammoxosome: an intracytoplasmic compartment bounded by a single ladderane lipid-containing membrane. The anammox bacteria, first found in a wastewater treatment plant in The Netherlands, have the potential to remove ammonium from wastewater without the addition of organic carbon. Very recently anammox bacteria were also discovered in the Black Sea where they are responsible for 30-50% of the nitrogen consumption. This review will introduce different forms of intracytoplasmic membrane systems found in prokaryotes and discuss the compartmentalization in anammox bacteria and its possible functional relation to catabolism and energy transduction.

  10. Distribution of perfluorinated compounds in blood compartments during prenatal exposure

    DEFF Research Database (Denmark)

    Nielsen, Flemming; Weihe, Pál; Grandjean, Philippe

    Perfluorinated compounds (PFCs) are a class of persistent environmental toxicants widely used in industrial and consumer products due to their unique chemical and physical properties. Knowledge on the health effects in humans is sparse and have most often been studied only for PFOS and PFOA......, but use of other PFCs are emerging, not at least after restriction of PFOS in the Stockholm Convention. Knowledge of prenatal exposure, and distribution between blood compartments for a wider range of PFCs in humans is therefore needed. We present prenatal exposure data for 19 perfluorinated organic...... carboxylic acids (PFCAs) and perfluoroalkyl sulfonates (PFSAs) ranging from C4-C12, as well as perfluorooctanesulfonamides (FOSAs) and perfluorooctanesulfonamidoacetic acids (FOSAAs). Maternal and foetal levels were significantly correlated for nearly all PFCs with median concentrations in cord serum ranging...

  11. Geochemical isotope compartment model of the nitrogen cycle

    International Nuclear Information System (INIS)

    Weise, G.; Wetzel, K.; Stiehl, G.

    1981-01-01

    A model of the global cycle of nitrogen and its isotopes is described. It takes into account geochemical reservoirs (nitrogen in magmatic metamorphic, and sedimentary rocks and in the atmosphere) and the nitrogen exchange between magmatic rocks and the outer mantle, the transition of nitrogen exchange between sedimentary rocks and the atmosphere. With the aid of the mathematical formalisms of the compartment theory and on the basis of all available delta 11 N values assumptions regarding the isotope effects in forming these nitrogen fluxes data have been obtained on the degree of the nitrogen exchange between the earth crust and the outer mantle and on other nitrogen fluxes characterizing the global nitrogen cycle. (author)

  12. Viral and Cellular Components of AAV2 Replication Compartments

    Science.gov (United States)

    Vogel, Rebecca; Seyffert, Michael; Pereira, Bruna de Andrade; Fraefel, Cornel

    2013-01-01

    Adeno-associated virus 2 (AAV2) is a helpervirus-dependent parvovirus with a bi-phasic life cycle comprising latency in absence and lytic replication in presence of a helpervirus, such as adenovirus (Ad) or herpes simplex virus type 1 (HSV-1). Helpervirus-supported AAV2 replication takes place in replication compartments (RCs) in the cell nucleus where virus DNA replication and transcription occur. RCs consist of a defined set of helper virus-, AAV2-, and cellular proteins. Here we compare the profile of cellular proteins recruited into AAV2 RCs or identified in Rep78-associated complexes when either Ad or HSV-1 is the helpervirus, and we discuss the potential roles of some of these proteins in AAV2 and helpervirus infection. PMID:24222808

  13. Microbial diversity in different compartments of an aquaponics system.

    Science.gov (United States)

    Schmautz, Zala; Graber, Andreas; Jaenicke, Sebastian; Goesmann, Alexander; Junge, Ranka; Smits, Theo H M

    2017-05-01

    Aquaponics is a solution for sustainable production of fish and plants in a single semi-closed system, where nutrient-rich water from the aquaculture provides nutrients for plant growth. We examined the microbial communities within an experimental aquaponics system. Whereas the fish feces contained a separate community dominated by bacteria of the genus Cetobacterium, the samples from plant roots, biofilter, and periphyton were more similar to each other, while the communities were more diverse. Detailed examination of the data gave the first indications to functional groups of organisms in the different compartments of the aquaponic system. As other nitrifiers other than members of the genus Nitrospira were only present at low numbers, it was anticipated that Nitrospirae may perform the nitrification process in the biofilm.

  14. Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.

    Directory of Open Access Journals (Sweden)

    Haizhong Zhu

    Full Text Available Kinesin-1 transports various cargos along the axon by interacting with the cargos through its light chain subunit. Kinesin light chains (KLC utilize its tetratricopeptide repeat (TPR domain to interact with over 10 different cargos. Despite a high sequence identity between their TPR domains (87%, KLC1 and KLC2 isoforms exhibit differential binding properties towards some cargos. We determined the structures of human KLC1 and KLC2 tetratricopeptide repeat (TPR domains using X-ray crystallography and investigated the different mechanisms by which KLCs interact with their cargos. Using isothermal titration calorimetry, we attributed the specific interaction between KLC1 and JNK-interacting protein 1 (JIP1 cargo to residue N343 in the fourth TRP repeat. Structurally, the N343 residue is adjacent to other asparagines and lysines, creating a positively charged polar patch within the groove of the TPR domain. Whereas, KLC2 with the corresponding residue S328 did not interact with JIP1. Based on these finding, we propose that N343 of KLC1 can form "a carboxylate clamp" with its neighboring asparagine to interact with JIP1, similar to that of HSP70/HSP90 organizing protein-1's (HOP1 interaction with heat shock proteins. For the binding of cargos shared by KLC1 and KLC2, we propose a different site located within the groove but not involving N343. We further propose a third binding site on KLC1 which involves a stretch of polar residues along the inter-TPR loops that may form a network of hydrogen bonds to JIP3 and JIP4. Together, these results provide structural insights into possible mechanisms of interaction between KLC TPR domains and various cargo proteins.

  15. Evaluation of the operational benefits versus costs of an automated cargo mover

    OpenAIRE

    Culp, Joshua; Feeney, Jon; Meus, Cleevens; Davis, Joshua; Kays, Jennifer; Summer, Jesse; Domondon, Richard; Martin Adam

    2016-01-01

    Approved for public release; distribution is unlimited This report examines the use of an automated robotic pallet mover during resupply missions in support of forward-deployed Marine units. The pallet mover is capable of loading and unloading itself and its cargo from MV-22 and CH-53 aircraft, and subsequently transporting that cargo 3,281 feet over unimproved terrain. The report explores the operationally relevant scenarios where a robotic pallet mover could be used, to determine whether...

  16. Using Monte Carlo Simulation To Improve Cargo Mass Estimates For International Space Station Commercial Resupply Flights

    Science.gov (United States)

    2016-12-01

    Historical Averages ................................... 22 Table 4. ISS Cargo Flights. Adapted from NASA at www.nasa.gov. ................ 41 Table 5...to pursue access to ISS by commercial means for both crew and cargo ( NASA 2004). B. COMMERCIAL ORBITAL TRANSPORTATION SERVICES PROGRAM Although...COTS Program that, in turn, delayed the start of ISS resupply in earnest under the CRS contract. NASA took care to stock ISS appropriately to cover

  17. Crystal Structures of the Tetratricopeptide Repeat Domains of Kinesin Light Chains: Insight into Cargo Recognition Mechanisms

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Haizhong; Lee, Han Youl; Tong, Yufeng; Hong, Bum-Soo; Kim, Kyung-Phil; Shen, Yang; Lim, Kyung Jik; Mackenzie, Farrell; Tempel, Wolfram; Park, Hee-Won (SGC-Toronto); (PPCS); (Toronto)

    2012-10-23

    Kinesin-1 transports various cargos along the axon by interacting with the cargos through its light chain subunit. Kinesin light chains (KLC) utilize its tetratricopeptide repeat (TPR) domain to interact with over 10 different cargos. Despite a high sequence identity between their TPR domains (87%), KLC1 and KLC2 isoforms exhibit differential binding properties towards some cargos. We determined the structures of human KLC1 and KLC2 tetratricopeptide repeat (TPR) domains using X-ray crystallography and investigated the different mechanisms by which KLCs interact with their cargos. Using isothermal titration calorimetry, we attributed the specific interaction between KLC1 and JNK-interacting protein 1 (JIP1) cargo to residue N343 in the fourth TRP repeat. Structurally, the N343 residue is adjacent to other asparagines and lysines, creating a positively charged polar patch within the groove of the TPR domain. Whereas, KLC2 with the corresponding residue S328 did not interact with JIP1. Based on these finding, we propose that N343 of KLC1 can form 'a carboxylate clamp' with its neighboring asparagine to interact with JIP1, similar to that of HSP70/HSP90 organizing protein-1's (HOP1) interaction with heat shock proteins. For the binding of cargos shared by KLC1 and KLC2, we propose a different site located within the groove but not involving N343. We further propose a third binding site on KLC1 which involves a stretch of polar residues along the inter-TPR loops that may form a network of hydrogen bonds to JIP3 and JIP4. Together, these results provide structural insights into possible mechanisms of interaction between KLC TPR domains and various cargo proteins.

  18. Research on combination forecast of port cargo throughput based on time series and causality analysis

    Directory of Open Access Journals (Sweden)

    Chi Zhang

    2013-03-01

    Full Text Available Purpose: The purpose of this paper is to develop a combined model composed of grey-forecast model and Logistic-growth-curve model to improve the accuracy of forecast model of cargo throughput for the port. The authors also use the existing data of a current port to verify the validity of the combined model.Design/methodology/approach: A literature review is undertaken to find the appropriate forecast model of cargo throughput for the port. Through researching the related forecast model, the authors put together the individual models which are significant to study further. Finally, the authors combine two individual models (grey-forecast model and Logistic-growth-curve model into one combined model to forecast the port cargo throughput, and use the model to a physical port in China to testify the validity of the model.Findings: Test by the perceptional data of cargo throughput in the physical port, the results show that the combined model can obtain relatively higher forecast accuracy when it is not easy to find more information. Furthermore, the forecast made by the combined model are more accurate than any of the individual ones.Research limitations/implications: The study provided a new combined forecast model of cargo throughput with a relatively less information to improve the accuracy rate of the forecast. The limitation of the model is that it requires the cargo throughput of the port have an S-shaped change trend.Practical implications: This model is not limited by external conditions such as geographical, cultural. This model predicted the port cargo throughput of one real port in China in 2015, which provided some instructive guidance for the port development.Originality/value: This is the one of the study to improve the accuracy rate of the cargo throughput forecast with little information.

  19. The intrinsic renal compartment syndrome: new perspectives in kidney transplantation.

    Science.gov (United States)

    Herrler, Tanja; Tischer, Anne; Meyer, Andreas; Feiler, Sergej; Guba, Markus; Nowak, Sebastian; Rentsch, Markus; Bartenstein, Peter; Hacker, Marcus; Jauch, Karl-Walter

    2010-01-15

    Inflammatory edema after ischemia-reperfusion may impair renal allograft function after kidney transplantation. This study examines the effect of edema-related pressure elevation on renal function and describes a simple method to relieve pressure within the renal compartment. Subcapsular pressure at 6, 12, 24, 48 hr, and 18 days after a 45 min warm ischemia was determined in a murine model of renal ischemia-reperfusion injury. Renal function was measured by Tc-MAG3 scintigraphy and laser Doppler perfusion. Structural damage was assessed by histologic analysis. As a therapeutic approach, parenchymal pressure was relieved by a standardized circular 0.3 mm incision at the lower pole of the kidney capsule. Compared with baseline (0.9+/-0.3 mm Hg), prolonged ischemia was associated with a sevenfold increase in subcapsular pressure 6 hr after ischemia (7.0+/-1.0 mm Hg; P<0.001). Pressure levels remained significantly elevated for 24 hr. Without therapy, a significant decrease in functional parameters was found with considerably reduced tubular excretion rate (33+/-3.5%, P<0.001) and renal perfusion (64.5+/-6.8%, P<0.005). Histologically, severe tissue damage was found. Surgical pressure relief was able to significantly prevent loss of tubular excretion rate (62.5+/-6.8%, P<0.05) and renal blood flow (96.2+/-4.8%; P<0.05) and preserved the integrity of renal structures. Our data support the hypothesis of the existence of a renal compartment syndrome as a consequence of ischemia-reperfusion injury. Surgical pressure relief effectively prevented functional and structural renal impairment, and we speculate that this approach might be of value for improving graft function after renal transplantation.

  20. Chemical heterogeneity of the striosomal compartment in the human striatum.

    Science.gov (United States)

    Prensa, L; Giménez-Amaya, J M; Parent, A

    1999-11-01

    The neurochemical organization of the striosomal compartment in the human striatum was analyzed by histochemical and immunohistochemical techniques applied to postmortem tissue from normal individuals. The striosomes were delineated by using the following markers: acetylcholinesterase (AChE), enkephalin (ENK), substance P (SP), calbindin-D28k (CB), parvalbumin (PV), calretinin (CR), limbic system-associated membrane protein (LAMP), choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and NADPH-diaphorase. Comparisons were made between striosomal boundaries, as outlined by each marker applied on adjacent sections, and particular attention was paid to possible variations in the chemical features of striosomes along the rostrocaudal extent of the striatum. The main findings of this study are as follows: 1) the striosomal compartment is composed of two chemically distinct domains: a core and a peripheral region; 2) the core is largely devoid of CB and displays a less intense staining for ENK and LAMP than the peripheral region; 3) although striosomes are largely devoid of AChE, the activity of this enzyme is slightly higher in the core than in the peripheral region; 4) the core and peripheral regions are weakly stained for PV and intensely stained for SP; 5) ChAT-, CR- and NADPH-diaphorase-positive neurons are preferentially distributed in the peripheral region; 6) at rostral striatal levels, striosomes are largely devoid of TH, whereas the inverse is true caudally; and 7) at caudal striatal levels, the peripheral region of striosomes is intensely stained for CB and ChAT. These results demonstrate that the striosomes in human display a strikingly complex and heterogeneous chemical architecture. Copyright 1999 Wiley-Liss, Inc.

  1. Acute Compartment Syndrome after an Olecranon Fracture in a Patient with Mild Hemophilia B

    OpenAIRE

    Reynolds, John M; Christophersen, Christy; Mulcahey, Mary K

    2017-01-01

    Introduction: Compartment syndrome is a serious condition characterized by compartmental pressures within 20 mmHg of diastolic blood pressure, or clinical signs of pain, paresthesia, pallor, and lack of pulses. Often a surgical intervention is necessary. Increased surveillance for compartment syndrome is important when a patient with a bleeding disorder sustains a traumatic injury. Case Report: We present a case of forearm compartment syndrome in a patient with mild hemophilia B who sustained...

  2. Case report: compartment syndrome after a suspected black widow spider bite.

    Science.gov (United States)

    Cohen, Jennifer; Bush, Sean

    2005-04-01

    Widow spider envenomations generally produce systemic neurologic syndromes without significant local injury. We report a patient who sustained a black widow spider bite to the left forearm and presented to the emergency department with rhabdomyolysis and compartment syndrome. We documented a decrease in symptoms and compartment pressure after administration of antivenom. No surgical intervention was performed. We believe this report to be the first documenting compartment syndrome associated with black widow spider bite.

  3. Irradiation Effects for the Pulsed Fast Neutron Analysis (PFNA) Cargo Interrogation System

    Energy Technology Data Exchange (ETDEWEB)

    Slater, C.O.

    2001-02-02

    At the request of Safety and Ecology Corporation of Tennessee, radiation effects of the proposed Pulsed Fast Neutron Analysis (PFNA) Cargo Interrogation System have been examined. First, fissile cargo were examined to determine if a significant neutron signal would be observable during interrogation. Results indicated that ample multiplication would be seen for near critical bare targets. The water-reflected sphere showed relatively little multiplication. By implication, a fissile target shielded by hydrogenous cargo might not be detectable by neutron interrogation, particularly if reliance is placed on the neutron signal. The cargo may be detectable if use can be made of the ample increase in the photon signal. Second, dose rates were calculated at various locations within and just outside the facility building. These results showed that some dose rates may be higher than the target dose rate of 0.05 mrem/h. However, with limited exposure time, the total dose may be well below the allowed total dose. Lastly, estimates were made of the activation of structures and typical cargo. Most cargo will not be exposed long enough to be activated to levels of concern. On the other hand, portions of the structure may experience buildup of some radionuclides to levels of concern.

  4. Improving customs’ border control by creating a reference database of cargo inspection X-ray images

    Directory of Open Access Journals (Sweden)

    Selina Kolokytha

    2017-04-01

    Full Text Available Countries’ effective and efficient border security is becoming increasingly important in today’s global world of economy and trade. To ensure these, customs organisations are responsible for the prevention of illicit goods’ transportation across borders, particularly upon entry. The predicament of the customs administrations will soon be aggravated by both the increase of global trade and the trend towards 100% screening. It is therefore a goal to advance inspection methods to enable successful cargo handling, a scope towards which this research was aimed at. This work was carried out as part of the project ACXIS “Automated Comparison of X-ray Images for cargo Scanning” a European research project within the seventh framework programme answering the call SEC-2012.3.4-1: « Research on Automated Comparison of X-ray Images for cargo Scanning », to improve the process with the largest impact to trade flow: the procedures of freight X-ray scanning. As such, this project was focused on to implementing a manufacturer independent reference database for X-ray images of illicit and non-illicit cargo, developing procedures and algorithms in order to uniform X-ray images of different cargo scanners, and developing a training simulator for inspection officers and a toolbox enclosing several assisted and automated identification techniques for potentially illicit cargo.

  5. Photon and neutron interrogation techniques for chemical explosives detection in air cargo: A critical review

    International Nuclear Information System (INIS)

    Runkle, Robert C.; White, Timothy A.; Miller, Erin A.; Caggiano, Joseph A.; Collins, Brian A.

    2009-01-01

    Scanning cargo transported via aircraft ('air cargo') for explosive threats is a problem that presently lacks a comprehensive technical solution. While chemical explosives detection in the baggage-scanning domain has a rich history that sheds light on potential solutions, air cargo differs in several important ways, and thus one cannot look to the present array of technologies. Some contemporary solutions, such as trace analysis, are not readily applied to cargo because of sampling challenges while the larger geometry of air cargo makes others less effective. This review article examines an array of interrogation techniques using photons and neutrons as incident particles. We first present a summary of the signatures and observables chemical explosives provide and review how they have been exploited in baggage scanning. Following this review is a description of the challenges posed by the air-cargo application space. After considering sources of photons and neutrons, we describe methods focused on transmission imaging, sub-surface examination, and elemental characterization. It is our goal to expand the understanding of each method's technical promise while largely deferring questions that revolve around footprint, safety, and conduct of operations. Our overarching intent is that a comprehensive understanding of potential techniques will foster the development of a comprehensive solution.

  6. A fluid membrane enhances the velocity of cargo transport by small teams of kinesin-1

    Science.gov (United States)

    Li, Qiaochu; Tseng, Kuo-Fu; King, Stephen J.; Qiu, Weihong; Xu, Jing

    2018-03-01

    Kinesin-1 (hereafter referred to as kinesin) is a major microtubule-based motor protein for plus-end-directed intracellular transport in live cells. While the single-molecule functions of kinesin are well characterized, the physiologically relevant transport of membranous cargos by small teams of kinesins remains poorly understood. A key experimental challenge remains in the quantitative control of the number of motors driving transport. Here we utilized "motile fraction" to overcome this challenge and experimentally accessed transport by a single kinesin through the physiologically relevant transport by a small team of kinesins. We used a fluid lipid bilayer to model the cellular membrane in vitro and employed optical trapping to quantify the transport of membrane-enclosed cargos versus traditional membrane-free cargos under identical conditions. We found that coupling motors via a fluid membrane significantly enhances the velocity of cargo transport by small teams of kinesins. Importantly, enclosing a cargo in a fluid lipid membrane did not impact single-kinesin transport, indicating that membrane-dependent velocity enhancement for team-based transport arises from altered interactions between kinesins. Our study demonstrates that membrane-based coupling between motors is a key determinant of kinesin-based transport. Enhanced velocity may be critical for fast delivery of cargos in live cells.

  7. Nonlinear roll damping of a barge with and without liquid cargo in spherical tanks

    Directory of Open Access Journals (Sweden)

    Wenhua Zhao

    2016-01-01

    Full Text Available Damping plays a significant role on the maximum amplitude of a vessel's roll motion, in particular near the resonant frequency. It is a common practice to predict roll damping using a linear radiation–diffraction code and add that to a linearized viscous damping component, which can be obtained through empirical, semi-empirical equations or free decay tests in calm water. However, it is evident that the viscous roll damping is nonlinear with roll velocity and amplitude. Nonlinear liquid cargo motions inside cargo tanks also contribute to roll damping, which when ignored impedes the accurate prediction of maximum roll motions. In this study, a series of free decay model tests is conducted on a barge-like vessel with two spherical tanks, which allows a better understanding of the nonlinear roll damping components considering the effects of the liquid cargo motion. To examine the effects of the cargo motion on the damping levels, a nonlinear model is adopted to calculate the damping coefficients. The liquid cargo motion is observed to affect both the linear and the quadratic components of the roll damping. The flow memory effect on the roll damping is also studied. The nonlinear damping coefficients of the vessel with liquid cargo motions in spherical tanks are obtained, which are expected to contribute in configurations involving spherical tanks.

  8. Air cargo market outlook and impact via the NASA CLASS project. [Cargo/Logistics Airlift Systems Study

    Science.gov (United States)

    Winston, M. M.; Conner, D. W.

    1980-01-01

    An overview is given of the Cargo/Logistics Airlift Systems Study (CLASS) project which was a 10 man-year effort carried out by two contractor teams, aimed at defining factors impacting future system growth and obtaining market requirements and design guidelines for future air freighters. Growth projection was estimated by two approaches: one, an optimal systems approach with a more efficient and cost effective system considered as being available in 1990; and the other, an evolutionary approach with an econometric behavior model used to predict long term evolution from the present system. Both approaches predict significant growth in demand for international air freighter services and less growth for U.S. domestic services. Economic analysis of air freighter fleet options indicate very strong market appeal of derivative widebody transports in 1990 with little incentive to develop all new dedicated air freighters utilizing the 1990's technology until sometime beyond the year 2000. Advanced air freighters would be economically attractive for a wide range of payload sizes (to 500 metric tons), however, if a government would share in the RD and T costs by virtue of its needs for a slightly modified version of a civil air freighter design (a.g. military airlifter).

  9. A New Approach to Uncertainty Reduction in Launch Vehicle Compartment Venting

    Data.gov (United States)

    National Aeronautics and Space Administration — Launch vehicle compartments are vented to the external environment during ascent to minimize undesirable structural loading. Prediction of venting performance is an...

  10. Length of encapsidated cargo impacts stability and structure of in vitro assembled alphavirus core-like particles

    Science.gov (United States)

    Rayaprolu, Vamseedhar; Moore, Alan; Che-Yen Wang, Joseph; Goh, Boon Chong; Perilla, Juan R.; Zlotnick, Adam; Mukhopadhyay, Suchetana

    2017-12-01

    In vitro assembly of alphavirus nucleocapsid cores, called core-like particles (CLPs), requires a polyanionic cargo. There are no sequence or structure requirements to encapsidate single-stranded nucleic acid cargo. In this work, we wanted to determine how the length of the cargo impacts the stability and structure of the assembled CLPs. We hypothesized that cargo neutralizes the basic region of the alphavirus capsid protein and if the cargo is long enough, it will also act to scaffold the CP monomers together. Experimentally we found that CLPs encapsidating short 27mer oligonucleotides were less stable than CLPs encapsidating 48mer or 90mer oligonucleotides under different chemical and thermal conditions. Furthermore, cryo-EM studies showed there were structural differences between CLPs assembled with 27mer and 48mer cargo. To mimic the role of the cargo in CLP assembly we made a mutant (4D) where we substituted a cluster of four Lys residues in the CP with four Asp residues. We found that these few amino acid substitutions were enough to initiate CLP assembly in the absence of cargo. The cargo-free 4D CLPs show higher resistance to ionic strength and increased temperature compared to wild-type cargo containing CLPs suggesting their CLP assembly mechanism might also be different.

  11. Detection of nuclear material by photon activation inside cargo containers

    Science.gov (United States)

    Gmar, Mehdi; Berthoumieux, Eric; Boyer, Sébastien; Carrel, Frédérick; Doré, Diane; Giacri, Marie-Laure; Lainé, Frédéric; Poumarède, Bénédicte; Ridikas, Danas; Van Lauwe, Aymeric

    2006-05-01

    Photons with energies above 6 MeV can be used to detect small amounts of nuclear material inside large cargo containers. The method consists in using an intense beam of high-energy photons (bremsstrahlung radiation) in order to induce reactions of photofission on actinides. The measurement of delayed neutrons and delayed gammas emitted by fission products brings specific information on localization and quantification of the nuclear material. A simultaneous measurement of both of these delayed signals can overcome some important limitations due to matrix effects like heavy shielding and/or the presence of light elements as hydrogen. We have a long experience in the field of nuclear waste package characterization by photon interrogation and we have demonstrated that presently the detection limit can be less than one gram of actinide per ton of package. Recently we tried to extend our knowledge to assess the performance of this method for the detection of special nuclear materials in sea and air freights. This paper presents our first results based on experimental measurements carried out in the SAPHIR facility, which houses a linear electron accelerator with the energy range from 15 MeV to 30 MeV. Our experiments were also modeled using the full scale Monte Carlo techniques. In addition, and in a more general frame, due to the lack of consistent data on photonuclear reactions, we have been working on the development of a new photonuclear activation file (PAF), which includes cross sections for more than 600 isotopes including photofission fragment distributions and delayed neutron tables for actinides. Therefore, this work includes also some experimental results obtained at the ELSA electron accelerator, which is more adapted for precise basic nuclear data measurements.

  12. Large area x-ray detectors for cargo radiography

    Science.gov (United States)

    Bueno, C.; Albagli, D.; Bendahan, J.; Castleberry, D.; Gordon, C.; Hopkins, F.; Ross, W.

    2007-04-01

    Large area x-ray detectors based on phosphors coupled to flat panel amorphous silicon diode technology offer significant advances for cargo radiologic imaging. Flat panel area detectors provide large object coverage offering high throughput inspections to meet the high flow rate of container commerce. These detectors provide excellent spatial resolution when needed, and enhanced SNR through low noise electronics. If the resolution is reduced through pixel binning, further advances in SNR are achievable. Extended exposure imaging and frame averaging enables improved x-ray penetration of ultra-thick objects, or "select-your-own" contrast sensitivity at a rate many times faster than LDAs. The areal coverage of flat panel technology provides inherent volumetric imaging with the appropriate scanning methods. Flat panel area detectors have flexible designs in terms of electronic control, scintillator selection, pixel pitch, and frame rates. Their cost is becoming more competitive as production ramps up for the healthcare, nondestructive testing (NDT), and homeland protection industries. Typically used medical and industrial polycrystalline phosphor materials such as Gd2O2S:Tb (GOS) can be applied to megavolt applications if the phosphor layer is sufficiently thick to enhance x-ray absorption, and if a metal radiator is used to augment the quantum detection efficiency and reduce x-ray scatter. Phosphor layers ranging from 0.2-mm to 1-mm can be "sandwiched" between amorphous silicon flat panel diode arrays and metal radiators. Metal plates consisting of W, Pb or Cu, with thicknesses ranging from 0.25-mm to well over 1-mm can be used by covering the entire area of the phosphor plate. In some combinations of high density metal and phosphor layers, the metal plate provides an intensification of 25% in signal due to electron emission from the plate and subsequent excitation within the phosphor material. This further improves the SNR of the system.

  13. Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome

    OpenAIRE

    Kirkpatrick, Andrew W; Roberts, Derek J; De Waele, Jan; Jaeschke, Roman; Malbrain, Manu LNG; De Keulenaer, Bart; Duchesne, Juan; Bjorck, Martin; Leppaniemi, Ari; Ejike, Janeth C; Sugrue, Michael; Cheatham, Michael; Ivatury, Rao; Ball, Chad G; Reintam Blaser, Annika

    2013-01-01

    Purpose To update the World Society of the Abdominal Compartment Syndrome (WSACS) consensus definitions and management statements relating to intra-abdominal hypertension (IAH) and the abdominal compartment syndrome (ACS). Methods We conducted systematic or structured reviews to identify relevant studies relating to IAH or ACS. Updated consensus definitions and management statements were then derived using a modified Delphi method and the Grading of Recommendations, Assessment, Development, a...

  14. The diagnostic value of MRI scans for the diagnosis of chronic exertional compartment syndrome of the lower leg

    Energy Technology Data Exchange (ETDEWEB)

    Verleisdonk, E.J.M.M.; Werken, C. van der [Dept. of Surgery, Univ. Hospital Utrecht (Netherlands); Gils, A. van [Dept. of Radiology, Univ. Hospital Utrecht (Netherlands)

    2001-06-01

    Objective. A prospective descriptive study to determine the value of magnetic resonance imaging (MRI) as an aid in diagnosing (chronic) exertional compartment syndrome.Design and patients. MRI was performed in 21 patients (41 anterior compartments) with chronic compartment syndrome at rest and following physical exercise. Median (T2-weighted) signal intensity on the MRI scan was determined in the anterior and the (superficial) posterior compartment of the lower leg before and after exercise. Postexercise increases in the signal intensity in these two compartments were compared. After fasciotomy, a second MRI scan was performed in 13 patients (25 anterior compartments) on the basis of the same protocol. MR studies were performed in 12 normal controls (24 anterior muscle compartments) on the basis of the same protocol.Results. T{sub 2}-weighted signal intensity increased by 27.5% (range 13.6-38.6%) following exercise in the anterior compartment of patients with a chronic compartment syndrome. In the posterior compartment this increase amounted to 4.25% (range 0-10.2%). Following fasciotomy, the increase in the anterior compartment was 4.1% (range 1.0-5.2%), while the increase in the posterior compartment amounted to 5.6% (range 0-11.0%), In normal controls, the increase in the anterior compartment was 7.6% (range 0-9.1%), while in the posterior compartment it was 4.0% (range 0-7.2%).Conclusions. In patients with a chronic compartment syndrome, the affected (anterior) compartment shows a statistically significant increase in (T2-weighted) signal intensity during exercise compared with both the (superficial) posterior compartment and the anterior compartment of normal controls. This effect disappeared after fasciotomy. In view of the substantial increase in T2-weighted signal intensity, MRI can be used in diagnosing chronic compartment syndrome. (orig.)

  15. A microvascular compartment model validated using 11C-methylglucose liver PET in pigs

    DEFF Research Database (Denmark)

    Munk, Ole Lajord; Keiding, Susanne; Baker, Charles

    2017-01-01

    The standard compartment model (CM) is widely used to analyze dynamic PET data. The CM is fitted to time-activity curves to estimate rate constants that describe the transport of tracer between well-mixed compartments. The aim of this study was to develop and validate a more realistic microvascul...

  16. Partitions, Compartments and Portals: Cave Development in internally impounded karst masses.

    Directory of Open Access Journals (Sweden)

    Osborne R. Armstrong L.

    2005-07-01

    Full Text Available Dykes and other vertical bodies can act as aquicludes within bodies of karst rock. These partitions separate isolated bodies of solublerock called compartments. Speleogenetically each compartment will behave as a small impounded-karst until the partition becomesbreached. Breaches through partitions, portals, allow water, air and biota including humans to pass between sections of caves thatwere originally isolated.

  17. AERODYNAMIC IMPROVEMENT OF KhADI 33 RACING CAR RADIATOR COMPARTMENT

    Directory of Open Access Journals (Sweden)

    A. Avershyn

    2011-01-01

    Full Text Available Aerodynamic characteristics of radiator compartment of KhADI 33 racing car on the basis of the decision of the interfaced problem of internal and external aerodynamics are numerically investigated. The rational variant of radiator compartment which is characterized by high throughput and low level of non-uniformity of speed field at the input is offered.

  18. 14 CFR 121.548 - Aviation safety inspector's credentials: Admission to pilot's compartment.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aviation safety inspector's credentials: Admission to pilot's compartment. 121.548 Section 121.548 Aeronautics and Space FEDERAL AVIATION... Operations § 121.548 Aviation safety inspector's credentials: Admission to pilot's compartment. Whenever, in...

  19. MR imaging of compartment syndrome of the lower leg: a case control study

    Energy Technology Data Exchange (ETDEWEB)

    Rominger, M.B. [Abteilung Strahlendiagnostik, Philipps-Universitaet Marburg, Baldingerstrasse, 35043, Marburg (Germany); Lukosch, C.J. [Medizinischer Dienst Hessen, Giessen (Germany); Bachmann, G.F. [Diagnostische Radiologie Kerckhoff-Klinik GmbH, Bad Nauheim (Germany)

    2004-08-01

    The aim of this study was to evaluate the use of MR imaging for diagnosis and therapy management of compartment syndromes. In total, 15 patients (5 with an imminent compartment syndrome and 10 with manifest compartment syndrome) underwent MR imaging with a variety of pulse sequences including fat suppression, magnetization transfer imaging, and intravenous gadopentetate dimeglumine (Gd-DTPA) administration. Early and late follow-up MR images were obtained. Manifest compartment syndromes showed swollen compartments with loss of normal muscle architecture on T1-weighted spin-echo images. T2-weighted spin-echo and magnetization transfer imaging showed bright areas, which enhanced after Gd-DTPA. Early follow-up showed changes in enhancement patterns; late follow-up showed fibrosis and cystic and fatty degenerations of the affected compartments. MR imaging can help make the diagnosis of a manifest compartment syndrome in clinically ambiguous cases. It points out the affected compartments and allows the surgeon to selectively split the fascial spaces. (orig.)

  20. The formation of endosymbiotic membrane compartments: membrane identity markers and the regulation of vesicle trafficking

    NARCIS (Netherlands)

    Ivanov, S.

    2012-01-01

    In symbiosis of plants and arbuscular mycorrhizal fungi as well as in rhizobium-legume symbiosis the microbes are hosted intracellularly, inside specialized membrane compartments of the host. These membrane compartments are morphologically different but similar in function, since they control the

  1. The formation of endosymbiotic membrane compartments: membrane identity markers and the regulation of vesicle trafficking

    NARCIS (Netherlands)

    Ivanov, S.

    2012-01-01

    In symbiosis of plants and arbuscular mycorrhizal fungi as well as in rhizobium-legume symbiosis the microbes are hosted intracellularly, inside specialized membrane compartments of the host. These membrane compartments are morphologically different but similar in function, since they control

  2. Validation of a multiple compartment model for the transport of cesium through animals

    International Nuclear Information System (INIS)

    Assimakopoulos, P.A.; Ioannides, K.G.; Pakou, A.A.

    1991-01-01

    A general multiple compartment model, which describes the transport of trace elements through animals is presented. This model considers a system of K interconnected compartments of volume V i , i = 1,2,....,K, each containing, at a given time t, N i molecules of a trace substance. (5 figs.)

  3. Stiffness and thickness of fascia do not explain chronic exertional compartment syndrome

    DEFF Research Database (Denmark)

    Dahl, Morten; Hansen, Philip; Stål, Per

    2011-01-01

    Chronic exertional compartment syndrome is diagnosed based on symptoms and elevated intramuscular pressure and often is treated with fasciotomy. However, what contributes to the increased intramuscular pressure remains unknown.......Chronic exertional compartment syndrome is diagnosed based on symptoms and elevated intramuscular pressure and often is treated with fasciotomy. However, what contributes to the increased intramuscular pressure remains unknown....

  4. Double pot and double compartment: integrating two approaches to study nutrient uptake by arbuscular mycorrhizal fungi

    NARCIS (Netherlands)

    Cardoso, I.M.; Boddington, C.L.; Janssen, B.H.; Oenema, O.; Kuyper, T.W.

    2004-01-01

    The double compartment technique has been commonly used in studies on nutrient uptake by mycorrhizas whereas the double pot technique has been used to assess the nutritional stress of plants grown in different soils. A combination of the double pot and the double compartment technique was used as a

  5. Compartment syndrome, rhabdomyolysis and risk of acute renal failure as complications of the lithotomy position.

    NARCIS (Netherlands)

    Bocca, G.; Moorselaar, R.J.A. van; Feitz, W.F.J.; Staak, F.H.J.M. van der; Monnens, L.A.H.

    2002-01-01

    Compartment syndrome, rhabdomyolysis and the risk of acute renal failure are potential complications of the lithotomy position. A six-year-old girl is described who developed a compartment syndrome with rhabdomyolysis after prolonged surgery in the lithotomy position. This complication occurred

  6. Status of the International Space Station Waste and Hygiene Compartment

    Science.gov (United States)

    Walker, Stephanie; Zahner, Christopher

    2010-01-01

    The Waste and Hygiene Compartment (WHC) serves as the primary system for removal and containment of metabolic waste and hygiene activities on board the United States segment of the International Space Station (ISS). The WHC was launched on ULF 2 and is currently in the U.S. Laboratory and is integrated into the Water Recovery System (WRS) where pretreated urine is processed by the Urine Processor Assembly (UPA). The waste collection part of the WHC system is derived from the Service Module system and was provided by RSC-Energia along with additional hardware to allow for urine delivery to the UPA. The System has been integrated in an ISS standard equipment rack structure for use on the U.S. segment of the ISS. The system has experienced several events of interest during the deployment, checkout, and operation of the system during its first year of use and these will be covered in this paper. Design and on-orbit performance will also be discussed.

  7. International Space Station USOS Waste and Hygiene Compartment Development

    Science.gov (United States)

    Link, Dwight E., Jr.; Broyan, James Lee, Jr.; Gelmis, Karen; Philistine, Cynthia; Balistreri, Steven

    2007-01-01

    The International Space Station (ISS) currently provides human waste collection and hygiene facilities in the Russian Segment Service Module (SM) which supports a three person crew. Additional hardware is planned for the United States Operational Segment (USOS) to support expansion of the crew to six person capability. The additional hardware will be integrated in an ISS standard equipment rack structure that was planned to be installed in the Node 3 element; however, the ISS Program Office recently directed implementation of the rack, or Waste and Hygiene Compartment (WHC), into the U.S. Laboratory element to provide early operational capability. In this configuration, preserved urine from the WHC waste collection system can be processed by the Urine Processor Assembly (UPA) in either the U.S. Lab or Node 3 to recover water for crew consumption or oxygen production. The human waste collection hardware is derived from the Service Module system and is provided by RSC-Energia. This paper describes the concepts, design, and integration of the WHC waste collection hardware into the USOS including integration with U.S. Lab and Node 3 systems.

  8. Engaging the lysosomal compartment to combat B cell malignancies

    DEFF Research Database (Denmark)

    Gronbaek, K.; Jaattela, M.

    2009-01-01

    The combination of rituximab, a type I anti-CD20 mAb, with conventional chemotherapy has significantly improved the outcome of patients with B cell malignancies. Regardless of this success, many patients still relapse with therapy-resistant disease, highlighting the need for the development of mAbs...... with higher capacity to induce programmed cell death. The so-called type II anti-CD20 mAbs (e.g., tositumomab) that trigger caspase-independent B cell lymphoma cell death in vitro and show superior efficacy as compared with rituximab in eradicating target cells in mouse models are emerging as the next...... generation of therapeutic anti-CD20 mAbs. In this issue of the JCI, Ivanov and colleagues identify the lysosomal compartment as a target for type II mAbs (see the related article beginning on page 2143). These data encourage the further clinical development of type II mAbs as well as other lysosome...

  9. Protein-synthesizing machinery in the axon compartment.

    Science.gov (United States)

    Koenig, E; Giuditta, A

    1999-03-01

    Contrary to the prevailing view that the axon lacks the capacity to synthesize proteins, a substantial body of evidence points to the existence of a metabolically active endogenous translational machinery. The machinery appears to be largely localized in the cortical zone of the axon, where, in vertebrate axons, it is distributed longitudinally as intermittent, discrete domains, called periaxoplasmic plaques. Studies, based on translation assays and probes of RNA transcripts in axon models such as the squid giant axon and selected vertebrate axons, provide evidence of locally synthesized proteins, most of which appear to be constituents of the slow axoplasmic transport rate groups. Metabolic and molecular biological findings are consistent with the view that the synthesis of proteins undergoing local turnover in the axonal compartment of macroneurons depends on the activity of an endogenous translational machinery. The documented presence of a metabolically active machinery in presynaptic terminals of squid photoreceptor neurons is also described. Finally, potential sources of axoplasmic RNAs comprising the machinery, which may include the ensheathing cell of the axon, as well as the cognate cell body, are also discussed.

  10. Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds

    Directory of Open Access Journals (Sweden)

    Helena Borland

    2017-01-01

    Full Text Available A mechanistic link between neuron-to-neuron transmission of secreted amyloid and propagation of protein malconformation cytopathology and disease has recently been uncovered in animal models. An enormous interest in the unconventional secretion of amyloids from neurons has followed. Amphisomes and late endosomes are the penultimate maturation products of the autophagosomal and endosomal pathways, respectively, and normally fuse with lysosomes for degradation. However, under conditions of perturbed membrane trafficking and/or lysosomal deficiency, prelysosomal compartments may instead fuse with the plasma membrane to release any contained amyloid. After a brief introduction to the endosomal and autophagosomal pathways, we discuss the evidence for autophagosomal secretion (exophagy of amyloids, with a comparative emphasis on Aβ1–42 and α-synuclein, as luminal and cytosolic amyloids, respectively. The ESCRT-mediated import of cytosolic amyloid into late endosomal exosomes, a known vehicle of transmission of macromolecules between cells, is also reviewed. Finally, mechanisms of lysosomal dysfunction, deficiency, and exocytosis are exemplified in the context of genetically identified risk factors, mainly for Parkinson’s disease. Exocytosis of prelysosomal or lysosomal organelles is a last resort for clearance of cytotoxic material and alleviates cytopathy. However, they also represent a vehicle for the concentration, posttranslational modification, and secretion of amyloid seeds.

  11. Determination of a ''microbial nitrogen'' compartment in soil

    International Nuclear Information System (INIS)

    Nicolardot, B.; Chaussod, R.; Guiraud, R.

    1983-07-01

    In laboratory studies, the authors tried to get to the microbial nitrogen compartment by the chloroform-fumigation technique as described by JENKINSON and POWLSON, using labelled ( 14 C and 15 N) microorganisms with various C/N ratios (from 5,1 to 12,7). The decomposition of this microbial organic matter was recorded in 3 different soils during a 28 days incubation at 28 0 C. The results pointed out that the mineralization rate of the 14 C microbial carbon was approximatively the same whatever the C/N ratio of the added organic matter, but showed significant variations with the soil type. Conversely, the mineralisation rate for 15 N varied much more with the C/N ratio of the decaying microbial organic 15 N than with the soil type: roughly 20 to 50% of the added organic 15 N was mineralized in 7 days at 28 0 C in the fumigated samples. The mineralization pattern of microbial nitrogen was quite different in the non-fumigated samples. On the other hand, kinetic study of the Mineral Nitrogen flush obtained after chlofoform fumigation has been started for one soil; these first results showed that the nitrogen flush can be explained by mathematical relations

  12. Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments.

    Directory of Open Access Journals (Sweden)

    Peter Ashcroft

    2017-10-01

    Full Text Available Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously migrating between these two compartments. Here we construct an individual-based mathematical model of this process, which is parametrised using existing empirical findings from mice. This approach allows us to quantify the amount of migration between the bone marrow niches and the peripheral blood. We use this model to investigate clonal hematopoiesis, which is a significant risk factor for hematologic cancers. We also analyse the engraftment of donor stem cells into non-conditioned and conditioned hosts, quantifying the impact of different treatment scenarios. The simplicity of the model permits a thorough mathematical analysis, providing deeper insights into the dynamics of both the model and of the real-world system. We predict the time taken for mutant clones to expand within a host, as well as chimerism levels that can be expected following transplantation therapy, and the probability that a preconditioned host is reconstituted by donor cells.

  13. A proposed benchmark problem for cargo nuclear threat monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, Thomas Wesley, E-mail: twholmes@ncsu.edu [Center for Engineering Applications of Radioisotopes, Nuclear Engineering Department, North Carolina State University, Raleigh, NC 27695-7909 (United States); Calderon, Adan; Peeples, Cody R.; Gardner, Robin P. [Center for Engineering Applications of Radioisotopes, Nuclear Engineering Department, North Carolina State University, Raleigh, NC 27695-7909 (United States)

    2011-10-01

    There is currently a great deal of technical and political effort focused on reducing the risk of potential attacks on the United States involving radiological dispersal devices or nuclear weapons. This paper proposes a benchmark problem for gamma-ray and X-ray cargo monitoring with results calculated using MCNP5, v1.51. The primary goal is to provide a benchmark problem that will allow researchers in this area to evaluate Monte Carlo models for both speed and accuracy in both forward and inverse calculational codes and approaches for nuclear security applications. A previous benchmark problem was developed by one of the authors (RPG) for two similar oil well logging problems (Gardner and Verghese, 1991, ). One of those benchmarks has recently been used by at least two researchers in the nuclear threat area to evaluate the speed and accuracy of Monte Carlo codes combined with variance reduction techniques. This apparent need has prompted us to design this benchmark problem specifically for the nuclear threat researcher. This benchmark consists of conceptual design and preliminary calculational results using gamma-ray interactions on a system containing three thicknesses of three different shielding materials. A point source is placed inside the three materials lead, aluminum, and plywood. The first two materials are in right circular cylindrical form while the third is a cube. The entire system rests on a sufficiently thick lead base so as to reduce undesired scattering events. The configuration was arranged in such a manner that as gamma-ray moves from the source outward it first passes through the lead circular cylinder, then the aluminum circular cylinder, and finally the wooden cube before reaching the detector. A 2 in.x4 in.x16 in. box style NaI (Tl) detector was placed 1 m from the point source located in the center with the 4 in.x16 in. side facing the system. The two sources used in the benchmark are {sup 137}Cs and {sup 235}U.

  14. 29 CFR 1918.89 - Handling hazardous cargo (See also § 1918.2 and § 1918.99).

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Handling hazardous cargo (See also § 1918.2 and § 1918.99). 1918.89 Section 1918.89 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... § 1918.89 Handling hazardous cargo (See also § 1918.2 and § 1918.99). Hazardous cargo shall be slung and...

  15. Current concepts in the pathophysiology, evaluation, and diagnosis of compartment syndrome

    Science.gov (United States)

    Hargens, A. R.; Mubarak, S. J.

    1998-01-01

    This article reviews present knowledge of the pathophysiology and diagnosis of acute compartment syndromes. Recent results using compression of legs in normal volunteers provide objective data concerning local pressure thresholds for neuromuscular dysfunction in the anterior compartment. Results with this model indicate that a progression of neuromuscular deficits occurs when IMP increases to within 35 to 40 mm Hg of diastolic blood pressure. These findings provide useful information on the diagnosis and compression thresholds for acute compartment syndromes. Time factors are also important, however, and usually are incompletely known in most cases of acute compartment syndrome. Although the slit catheter is a very good technique for monitoring IMP during rest, these catheters and their associated extracorporeal transducer systems are not ideal. Recently developed miniature transducer-tipped catheters and, perhaps, future development of noninvasive techniques may provide accurate recordings of IMP in patients with acute compartment syndromes.

  16. Diagnosis and Treatment of Chronic Exertional Compartment Syndrome - a Proposition for an Algorithm

    DEFF Research Database (Denmark)

    Larsen, Peter Birk; Jensen, Steffen Skov

    Title: Diagnosis and treatment of chronic exertional compartment syndrome - a proposition for an algorithm based on case series of patients treated at Sports Medicine Division, Department of Orthopaedic Surgery, Viborg Regional Hospital, Denmark Background: Chronic exertional compartment syndrome...... (CECS) is a well recognized but often under diagnosed cause of chronic exertional lower extremity pain, most often encountered in young physically active individuals. Aim of Study: The aim of this preliminary study is to present an algorithm for diagnosis and treatment of CECS. We hypothesize...... in conjunction with a thorough medical history formed the basis for the diagnosis. Results: 11 patients were offered surgical treatment consisting of EASF of the affected compartment (10 bilateral and 1 unilateral, 8 affected in specific compartments and 3 affected in all compartments. Only 1 patient required...

  17. Spatial relationships and movement patterns of the air cargo industry in airport regions

    Directory of Open Access Journals (Sweden)

    Petrus J. van V. Coetzee

    2017-05-01

    Full Text Available Background: During the past few years, with the increase in air traffic and the expansion of airports, very few industries had such a large spatial development and movement impact as that of airport-related clusters or airport regions. Although much research was done on the various impacts of the airport industry, very little research was done on the air cargo industry in airport regions. Objectives: This article specifically explored the unique spatial relationships, impacts, trends and movement patterns of the air cargo industry within a typical airport region. Method: The article focused on the OR Tambo International Airport in Gauteng, South Africa, as a case study and was informed by an extensive quantitative spatial and land use analysis and modelling of the study area. Results: The article presented findings and insights on the movement patterns and relationships between (1 the airport facility and (2 the spatial configuration of air cargo industries in the particular airport region. These findings also provided some framework for a possible spatial model and guideline that could assist in steering and managing development and movement patterns in airport regions. Conclusion: The article provided new insights and understanding on the spatial dynamics of airport regions and the air cargo industry, ultimately addressing some gaps in this knowledge field. The article in the end highlighted the need for a different and novel approach to the planning and management of the air cargo industry in airport regions and a basis for further research.

  18. Container cargo simulation modeling for measuring impacts of infrastructure investment projects in Pearl River Delta

    Science.gov (United States)

    Li, Jia-Qi; Shibasaki, Ryuichi; Li, Bo-Wei

    2010-03-01

    In the Pearl River Delta (PRD), there is severe competition between container ports, particularly those in Hong Kong, Shenzhen, and Guangzhou, for collecting international maritime container cargo. In addition, the second phase of the Nansha terminal in Guangzhou’s port and the first phase of the Da Chang Bay container terminal in Shenzhen opened last year. Under these circumstances, there is an increasing need to quantitatively measure the impact these infrastructure investments have on regional cargo flows. The analysis should include the effects of container terminal construction, berth deepening, and access road construction. The authors have been developing a model for international cargo simulation (MICS) which can simulate the movement of cargo. The volume of origin-destination (OD) container cargo in the East Asian region was used as an input, in order to evaluate the effects of international freight transportation policies. This paper focuses on the PRD area and, by incorporating a more detailed network, evaluates the impact of several infrastructure investment projects on freight movement.

  19. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery

    Energy Technology Data Exchange (ETDEWEB)

    Mancias, Joseph D.; Goldberg, Jonathan (MSKCC)

    2008-11-18

    Genomic analysis shows that the increased complexity of trafficking pathways in mammalian cells involves an expansion of the number of SNARE, Rab and COP proteins. Thus, the human genome encodes four forms of Sec24, the cargo selection subunit of the COPII vesicular coat, and this is proposed to increase the range of cargo accommodated by human COPII-coated vesicles. In this study, we combined X-ray crystallographic and biochemical analysis with functional assays of cargo packaging into COPII vesicles to establish molecular mechanisms for cargo discrimination by human Sec24 subunits. A conserved IxM packaging signal binds in a surface groove of Sec24c and Sec24d, but the groove is occluded in the Sec24a and Sec24b subunits. Conversely, LxxLE class transport signals and the DxE signal of VSV glycoprotein are selectively bound by Sec24a and Sec24b subunits. A comparative analysis of crystal structures of the four human Sec24 isoforms establishes the structural determinants for discrimination among these transport signals, and provides a framework to understand how an expansion of coat subunits extends the range of cargo proteins packaged into COPII-coated vesicles.

  20. Numerical analysis of air-flow and temperature field in a passenger car compartment

    Science.gov (United States)

    Kamar, Haslinda Mohamed; Kamsah, Nazri; Mohammad Nor, Ahmad Miski

    2012-06-01

    This paper presents a numerical study on the temperature field inside a passenger's compartment of a Proton Wira saloon car using computational fluid dynamics (CFD) method. The main goal is to investigate the effects of different glazing types applied onto the front and rear windscreens of the car on the distribution of air-temperature inside the passenger compartment in the steady-state conditions. The air-flow condition in the passenger's compartment is also investigated. Fluent CFD software was used to develop a three-dimensional symmetrical model of the passenger's compartment. Simplified representations of the driver and one rear passenger were incorporated into the CFD model of the passenger's compartment. Two types of glazing were considered namely clear insulated laminated tint (CIL) with a shading coefficient of 0.78 and green insulated laminate tint (GIL) with a shading coefficient of 0.5. Results of the CFD analysis were compared with those obtained when the windscreens are made up of clear glass having a shading coefficient of 0.86. Results of the CFD analysis show that for a given glazing material, the temperature of the air around the driver is slightly lower than the air around the rear passenger. Also, the use of GIL glazing material on both the front and rear windscreens significantly reduces the air temperature inside the passenger's compartment of the car. This contributes to a better thermal comfort condition to the occupants. Swirling air flow condition occurs in the passenger compartment. The air-flow intensity and velocity are higher along the side wall of the passenger's compartment compared to that along the middle section of the compartment. It was also found that the use of glazing materials on both the front and rear windscreen has no significant effects on the air-flow condition inside the passenger's compartment of the car.

  1. Pre test parametric studies on single compartment vented enclosure

    International Nuclear Information System (INIS)

    Sharma, Pavan K.; Gera, B.; Singh, R.K.; Vaze, K.K.

    2011-01-01

    Establishing a proper design fire scenario is a challenging task and essential component for conducting fire safety design of buildings. A design fire scenario is a qualitative description of a fire with time identifying key events that characterize the fire (ignition, growth, flashover, fully-developed, and decay stages of fire). Proper fire safety design requires the appropriate selection of design fires against which the performance of the building is evaluated. The selection of the design fires directly impacts all aspects of fire safety performance, including the structural fire resistance, compartmentation against fire spread, egress systems, manual or automatic detection systems, suppression systems, and smoke control. The parameters affecting design fires include, the type, amount and arrangement of combustible materials, the ventilation conditions (air supply conditions, door/window open), and size of the compartment of fire origin. A design fire is a quantitative description of the characteristics of a fire, such as heat release rate (HRR), size of fire and its rate of spread, yield of products of combustion, and hot gas temperatures. Design fires are based on fire scenarios that replicate real fires. Six Computational Fluid Dynamics (CFD) numerical simulations were conducted in order to investigate the effect of fire load on fire dynamics in a) iso corner fire configuration b) IIT Delhi single compartment of a size of 5.0 m long, 5.0 m wide and 5.0 m high with doorway opening of 1m x 3m with centre fire of size 0.5 m x 0.5m. These types of simulation are carried out for deciding about the instrumentation scheme, safety aspect, and optimization of proposed experiments for National Fire Test Facility as pretest calculations. The simulations results are summarized in various identified applied parameter which are useful in terms of understanding the complex fire dynamics, validating the numerical tolls against experiments and using them (in form of values

  2. Unsupervised morphological segmentation of tissue compartments in histopathological images.

    Directory of Open Access Journals (Sweden)

    Shereen Fouad

    Full Text Available Algorithmic segmentation of histologically relevant regions of tissues in digitized histopathological images is a critical step towards computer-assisted diagnosis and analysis. For example, automatic identification of epithelial and stromal tissues in images is important for spatial localisation and guidance in the analysis and characterisation of tumour micro-environment. Current segmentation approaches are based on supervised methods, which require extensive training data from high quality, manually annotated images. This is often difficult and costly to obtain. This paper presents an alternative data-independent framework based on unsupervised segmentation of oropharyngeal cancer tissue micro-arrays (TMAs. An automated segmentation algorithm based on mathematical morphology is first applied to light microscopy images stained with haematoxylin and eosin. This partitions the image into multiple binary 'virtual-cells', each enclosing a potential 'nucleus' (dark basins in the haematoxylin absorbance image. Colour and morphology measurements obtained from these virtual-cells as well as their enclosed nuclei are input into an advanced unsupervised learning model for the identification of epithelium and stromal tissues. Here we exploit two Consensus Clustering (CC algorithms for the unsupervised recognition of tissue compartments, that consider the consensual opinion of a group of individual clustering algorithms. Unlike most unsupervised segmentation analyses, which depend on a single clustering method, the CC learning models allow for more robust and stable detection of tissue regions. The proposed framework performance has been evaluated on fifty-five hand-annotated tissue images of oropharyngeal tissues. Qualitative and quantitative results of the proposed segmentation algorithm compare favourably with eight popular tissue segmentation strategies. Furthermore, the unsupervised results obtained here outperform those obtained with individual

  3. Unsupervised morphological segmentation of tissue compartments in histopathological images.

    Science.gov (United States)

    Fouad, Shereen; Randell, David; Galton, Antony; Mehanna, Hisham; Landini, Gabriel

    2017-01-01

    Algorithmic segmentation of histologically relevant regions of tissues in digitized histopathological images is a critical step towards computer-assisted diagnosis and analysis. For example, automatic identification of epithelial and stromal tissues in images is important for spatial localisation and guidance in the analysis and characterisation of tumour micro-environment. Current segmentation approaches are based on supervised methods, which require extensive training data from high quality, manually annotated images. This is often difficult and costly to obtain. This paper presents an alternative data-independent framework based on unsupervised segmentation of oropharyngeal cancer tissue micro-arrays (TMAs). An automated segmentation algorithm based on mathematical morphology is first applied to light microscopy images stained with haematoxylin and eosin. This partitions the image into multiple binary 'virtual-cells', each enclosing a potential 'nucleus' (dark basins in the haematoxylin absorbance image). Colour and morphology measurements obtained from these virtual-cells as well as their enclosed nuclei are input into an advanced unsupervised learning model for the identification of epithelium and stromal tissues. Here we exploit two Consensus Clustering (CC) algorithms for the unsupervised recognition of tissue compartments, that consider the consensual opinion of a group of individual clustering algorithms. Unlike most unsupervised segmentation analyses, which depend on a single clustering method, the CC learning models allow for more robust and stable detection of tissue regions. The proposed framework performance has been evaluated on fifty-five hand-annotated tissue images of oropharyngeal tissues. Qualitative and quantitative results of the proposed segmentation algorithm compare favourably with eight popular tissue segmentation strategies. Furthermore, the unsupervised results obtained here outperform those obtained with individual clustering algorithms.

  4. Variable actin dynamics requirement for the exit of different cargo from the trans-Golgi network.

    Science.gov (United States)

    Lázaro-Diéguez, Francisco; Colonna, Cecilia; Cortegano, Miguel; Calvo, María; Martínez, Susana E; Egea, Gustavo

    2007-08-07

    Efficient post-Golgi trafficking depends on microtubules, but actin filaments and actin-associated proteins are also postulated. Here we examined, by inverse fluorescence recovery after photobleaching, the role of actin dynamics in the exit from the TGN of fluorescent-tagged apical or basolateral and raft or non-raft-associated cargoes. Either the actin-stabilizing jasplakinolide or the actin-depolymerising latrunculin B variably but significantly inhibited post-Golgi traffic of non-raft associated apical p75NTR and basolateral VSV-G cargoes. The TGN-exit of the apical-destined VSV-G mutant was impaired only by latrunculin B. Strikingly, the raft-associated GPI-anchor protein was not affected by either actin toxin. Results indicate that actin dynamics participates in the TGN egress of both apical- and basolateral-targeted proteins but is not needed for apical raft-associated cargo.

  5. Automated X-ray image analysis for cargo security: Critical review and future promise.

    Science.gov (United States)

    Rogers, Thomas W; Jaccard, Nicolas; Morton, Edward J; Griffin, Lewis D

    2017-01-01

    We review the relatively immature field of automated image analysis for X-ray cargo imagery. There is increasing demand for automated analysis methods that can assist in the inspection and selection of containers, due to the ever-growing volumes of traded cargo and the increasing concerns that customs- and security-related threats are being smuggled across borders by organised crime and terrorist networks. We split the field into the classical pipeline of image preprocessing and image understanding. Preprocessing includes: image manipulation; quality improvement; Threat Image Projection (TIP); and material discrimination and segmentation. Image understanding includes: Automated Threat Detection (ATD); and Automated Contents Verification (ACV). We identify several gaps in the literature that need to be addressed and propose ideas for future research. Where the current literature is sparse we borrow from the single-view, multi-view, and CT X-ray baggage domains, which have some characteristics in common with X-ray cargo.

  6. Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release

    KAUST Repository

    Li, Song

    2015-04-27

    Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large-cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene-alkoxysilane [NB; 3-nitro-N-(3-(triethoxysilyl)propyl)-4-(((3-(triethoxysilyl)propyl)-amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light-triggered release of cargos. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Design of an experiment to measure fire exposure of packages aboard container cargo ships

    International Nuclear Information System (INIS)

    Koski, J.A.

    1998-01-01

    The test described in this paper is intended to measure the typical accident environment for a radioactive materials package in a fire abroad a container cargo ship. A stack of nice used standard cargo containers will be variously loaded with empty packages, simulated packages and combustible cargo and placed over a large hydrocarbon pool fire of one hour duration. Fire environments, both inside and outside the containers, typical of on-deck stowage will be measured as well as the potential for container-to-container fire spread. With the use of the inverse heat conduction calculations, the local heat transfer to the simulated packages can be estimated from thermocouple data. Data recorded will also provide information on fire durations in each container, fire intensity and container-to-container fire spread characteristics. (authors)

  8. A MATHEMATICAL MODEL OF THE MILITARY TRANSPORT AIRCRAFT MOVEMENT AT CARGO ITEM DROP

    Directory of Open Access Journals (Sweden)

    2016-01-01

    Full Text Available The controllability of military transport aircraft deteriorates at heavy single piece landing. To solve this problem and a specific methodology for pilotage of the pre-emption, and automation tools are being developed. Preliminary study ofpilotage technique and authomatic control algorythm demand a reliable mathematical model of aircraft dynamics at cargo item drop. Such model should take into account significant change in the position of the aircraft center of mass and aircraft inertia tensor. Simplified models were based on modeling the movement of the center of mass and rotation around the cen- ter of mass of the aircraft. Such models do not take into account the inertial forces and moments of moving a cargo item. This circumstance does not allow to obtain reliable results in the simulation. The article presents the description of the complete mathematical model of the movement of military transport aircraft in landing of a cargo item. Examines the com- plex material system of solids and a detailed description of the properties of its components. The equations of motion of the aircraft as a system carrier (aircraft without a cargo item and wear (of moving a cargo item bodies to reflect the changes in the inertia tensor. The functioning of the power plant, steering actuators, flight control system, an exhaust chute, the sen- sors of the primary information are taken into account. The equations of motion for systems of bodies projected on the air- craft reference plane are being recorded. This approach takes into account changes of the inertia tensor and the position of the main central axes of inertia in the process of landing of a cargo item. It allows us to simulate the condition of the air- craft at all speeds of the pitch, normal overload, and masses of single piece and placement, as evidenced by the high con- vergence of modeling results with data from flight tests.

  9. An anatomic and biomechanic study of the wrist extensor retinaculum septa and tendon compartments.

    Science.gov (United States)

    Iwamoto, Akira; Morris, Randal P; Andersen, Clark; Patterson, Rita M; Viegas, Steven F

    2006-01-01

    The anatomy of the extensor retinaculum of the wrist has been described previously; the purpose of this study was to describe the specific anatomy of the septal attachments on the radius and to investigate the mechanical strength of each septal attachment on the radius and each of the 6 compartments of the extensor retinaculum. Thirty-four wrists from 24 fresh-frozen and 10 embalmed cadavers were used. First, anatomic measurements of the individual extensor retinaculum septums were performed with calipers and a 3-dimensional digitizer. Next each extensor retinaculum septum was excised as a bone-retinaculum-bone autograft and was tested in tension to failure with a materials testing machine. Finally the 6 extensor retinaculum compartments were tested to failure. Septum 1/2 had the largest radial surface area and septum 3/4 had the smallest. Septum 1/2 also was found to have the highest failure strength at 51.3 +/- 15.3 N. In compartment testing, compartments 1 and 2 had the highest overall resistance to failure and compartment 5 had the lowest. Compartment 6, which was thought to be the weakest because of clinically observed subluxation of the extensor carpi ulnaris tendon, had stronger failure data than expected. This study offers detailed analysis of the extensor retinaculum compartments and 3-dimensional anatomy of the septal attachments. Clinically this study lends insight to the strength of bone-retinaculum-bone autografts and the etiology of extensor carpi ulnaris subluxation.

  10. 76 FR 10482 - Special Conditions: Boeing Model 787-8 Airplane; Overhead Flightcrew-Rest Compartment Occupiable...

    Science.gov (United States)

    2011-02-25

    ... sufficient in regard to these regulations. The two OFCR compartment seats are only a couple of steps away... (representative of a 95th percentile male) from the OFCR compartment to the passenger cabin floor. (a) Such an...

  11. A Benchmarking of Operational Efficiency in Asia Pacific International Cargo Airports

    Directory of Open Access Journals (Sweden)

    Tae-won Chung

    2015-03-01

    Full Text Available This paper compares operational efficiency of major cargo airports in the Asia Pacific region. The multi-dimensional scaling cluster analysis by R-square method was used as the benchmarking tool to provide airport management with a means to examine various aspects of their operational efficiency against those of other airports. Ten operational efficiency factors for the clustering and efficiency estimation of airports in the Asia Pacific region were used in a regression model to overcome the complexity of multi-dimensional scaling approach. The resulting classification is used to identify the efficiency benchmarks of leading air cargo airports which have implications for Incheon airport in Korea.

  12. An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

    Science.gov (United States)

    Dagdas, Yasin F; Belhaj, Khaoula; Maqbool, Abbas; Chaparro-Garcia, Angela; Pandey, Pooja; Petre, Benjamin; Tabassum, Nadra; Cruz-Mireles, Neftaly; Hughes, Richard K; Sklenar, Jan; Win, Joe; Menke, Frank; Findlay, Kim; Banfield, Mark J; Kamoun, Sophien; Bozkurt, Tolga O

    2016-01-01

    Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses. DOI: http://dx.doi.org/10.7554/eLife.10856.001 PMID:26765567

  13. Use of ABC–XYZ–analysis in cost management of the cargo turnover in transport logistics

    OpenAIRE

    Chukurna O.; Davydova A.

    2017-01-01

    This article focuses on the relevance of the use of ABC–XYZ–analysis in the management of cargo turnover costs in the implementation of transport and logistics operations. It proposed by using the ABC analysis to rank suppliers or customers of freight turnover and the cost of each logistics operation (or profitability of the logistics services). On the basis of the received data to optimise logistics costs. It is proposed to use the XYZ–analysis to predict the volume of cargo turnover and a l...

  14. THE PROBLEM OF PROPER CARGO SECURING IN ROAD TRANSPORT – CASE STUDY

    Directory of Open Access Journals (Sweden)

    Maria CIEŚLA

    2013-12-01

    Full Text Available This paper presents the problem of improper security of cargo in trucks as the cause of about 25% of the accidents that takes place in road transport. Attention was drawn to aspects of legal liability for errors resulting from incorrect load securing according to polish law. Article was enriched with practical examples illustrating the effects of improper cargo securing on transport unit and shows how it had to be prepared properly. When planning the proper transport protection of metal sheets rolled both calculation methods and computer applications were used.

  15. Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

    Science.gov (United States)

    Brinker, C Jeffrey; Ashley, Carlee Erin; Jiang, Xingmao; Liu, Juewen; Peabody, David S; Wharton, Walker Richard; Carnes, Eric; Chackerian, Bryce; Willman, Cheryl L

    2015-03-31

    Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

  16. Acceso de las mujeres a los cargos directivos: universidades con techo de cristal

    OpenAIRE

    Ricardo Gaete Quezada

    2018-01-01

    Se analiza el techo de cristal desde las percepciones y experiencias de las académicas respecto del acceso a los cargos directivos en sus instituciones universitarias, materializado en barreras internas o externas que afectan su carrera laboral. La investigación se desarrolla a través de un estudio de caso de dos universidades chilenas, considerando el uso de metodología cualitativa recopilando la información a través de entrevistas semi-estructuradas con académicas que se desempeñan en cargo...

  17. Bilateral post-traumatic gluteal compartment syndrome: A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Devashis Barick

    2015-01-01

    Full Text Available Gluteal compartment is a rare site for compartment syndrome. Gluteal compartment syndrome has most commonly been described in the literature as occurring after prolonged immobility associated with substance abuse, improper operative positioning, sickle cell-induced infarct, post-traumatic and spontaneous superior gluteal artery rupture, exercise, and post-arterial embolization of the internal iliac artery prior to abdominal aortic aneurysm repair. Trauma is rarely associated with this syndrome. Gluteal compartment syndrome occurs in approximately 0.9% of trauma patients. Posttraumatic gluteal compartment syndrome develops because of edema with traumatic contusions, crush injuries and hematoma formation due to blunt superior or inferior gluteal artery injuries in all compartments of the gluteal region Only 6 previous cases have been reported in the literature. Two previous cases involved positioning for urological procedures, while the other cited causes of bilateral gluteal compartment syndrome include exercise-induced, trauma, and prolonged immobilization from substance abuse. One of the most immediately devastating results of a missed compartment syndrome is the risk of the development of rhabdomyolysis with the resulting squeal of myoglobinuria, hyperkalemia, and acidosis resulting in renal failure, shock, multiple organ failure, disseminated intravascular coagulation, and possibly death. Here we report a case of posttraumatic bilateral compartment syndrome which developed secondary to pressure due to patient being trapped under a vehicle following a vehicular accident. He was operated upon and a bilateral fasciotomy was done. Although he did not develop any renal complications, the sciatic nerve palsy on the left side did not recover. The patient is still under follow up.

  18. [Orbital compartment syndrome. The most frequent cause of blindness following facial trauma].

    Science.gov (United States)

    Klenk, Gusztáv; Katona, József; Kenderfi, Gábor; Lestyán, János; Gombos, Katalin; Hirschberg, Andor

    2017-09-01

    Although orbital compartment syndrome is a rare condition, it is still the most common cause of blindness following simple or complicated facial fractures. Its pathomechanism is similar to the compartment syndrome in the limb. Little extra fluid (blood, oedema, brain, foreign body) in a non-space yielding space results with increasingly higher pressures within a short period of time. Unless urgent surgical intervention is performed the blocked circulation of the central retinal artery will result irreversible ophthalmic nerve damage and blindness. Aim, material and method: A retrospective analysis of ten years, 2007-2017, in our hospital among those patients referred to us with facial-head trauma combined with blindness. 571 patients had fractures involving the orbit. 23 patients become blind from different reasons. The most common cause was orbital compartment syndrome in 17 patients; all had retrobulbar haematomas as well. 6 patients with retrobulbar haematoma did not develop compartment syndrome. Compartment syndrome was found among patient with extensive and minimal fractures such as with large and minimal haematomas. Early lateral canthotomy and decompression saved 7 patients from blindness. We can not predict and do not know why some patients develop orbital compartment syndrome. Compartment syndrome seems independent from fracture mechanism, comminution, dislocation, amount of orbital bleeding. All patients are in potential risk with midface fractures. We have a high suspicion that orbital compartment syndrome has been somehow missed out in the recommended textbooks of our medical universities and in the postgraduate trainings. Thus compartment syndrome is not recognized. Teaching, training and early surgical decompression is the only solution to save the blind eye. Orv Hetil. 2017; 158(36): 1410-1420.

  19. Compartment and Crush Syndromes After Sleep Deprivation and a Therapeutic Dose of Zolpidem

    Directory of Open Access Journals (Sweden)

    Martin R. Huecker

    2017-07-01

    Full Text Available Despite extensive review in the literature, compartment syndrome and crush syndrome remain difficult to diagnose. Trauma, toxins and reperfusion have been associated with these syndromes. Cases involving alcohol and drug abuse have described patients “found down” compressing an extremity. We present a case of a registered nurse who developed compartment syndrome in multiple limbs due to prolonged sleep after sleep deprivation and zolpidem use. To our knowledge, this is the first case of compartment syndrome or crush syndrome to have occurred in the setting of zolpidem use. Sleep disruption in healthcare workers represents a public health issue with dangerous sequelae, both acute and chronic.

  20. Gluteal compartment syndrome following drug-induced immobilization: a case report.

    Science.gov (United States)

    Panagiotopoulos, Andreas Christos; Vrachnis, Ioannis; Kraniotis, Pantelis; Tyllianakis, Minos

    2015-02-08

    Gluteal compartment syndrome is a very rare condition characterized by non-specific symptoms that often lead to misdiagnosis. We report a case of gluteal compartment syndrome in a 38 year-old Caucasian male (intravenous drug user) following prolonged immobilization due to loss of consciousness. The delay in the appropriate diagnosis and treatment led to a temporary acute kidney injury and to irreversible sciatic nerve palsy. Delay in the definitive diagnosis and treatment of gluteal compartment syndrome, may lead to higher morbidity of the affected extremity and in rare cases even patient mortality. Special emphasis is given to the aetiology, symptomatology, differential diagnosis as well as the treatment of this condition.

  1. Chronic exertional compartment syndrome in a collegiate soccer player: a case report and literature review.

    Science.gov (United States)

    Farr, Derek; Selesnick, Harlan

    2008-07-01

    Chronic exertional compartment syndrome is a relatively rare condition among running athletes. In those who engage in repetitive activity, it can cause severe, debilitating leg pain. The diagnosis can be made with a thorough workup that includes history and physical examination, radiologic studies (x-rays, magnetic resonance imaging, bone scan), and compartment pressure monitoring. Most patients do not respond well to nonoperative intervention. Fasciotomy provides satisfactory relief of symptoms and helps patients return to their sports. We present the case of a high-level collegiate soccer player with chronic exertional compartment syndrome.

  2. 49 CFR 178.337 - Specification MC 331; cargo tank motor vehicle primarily for transportation of compressed gases...

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification MC 331; cargo tank motor vehicle primarily for transportation of compressed gases as defined in subpart G of part 173 of this subchapter. 178... MC 331; cargo tank motor vehicle primarily for transportation of compressed gases as defined in...

  3. 46 CFR 30.25-1 - Cargoes carried in vessels certificated under the rules of this subchapter.

    Science.gov (United States)

    2010-10-01

    ... Combustible Bulk Liquid Cargoes Cargo name IMOAnnex II Pollution Category Acetone III Acetophenone @D...-Decylbenzene, see Alkyl(C9+)benzenes III Detergent alkylate D Diacetone alcohol D Dialkyl(C10-C14) benzenes.... Sodium acetate, Glycol, Water mixture (containing 1% or less, Sodium hydroxide) (if flammable or...

  4. 78 FR 11981 - Security Zone; Protection of Military Cargo, Captain of the Port Zone Puget Sound, WA

    Science.gov (United States)

    2013-02-21

    ... Zone; Protection of Military Cargo, Captain of the Port Zone Puget Sound, WA AGENCY: Coast Guard, DHS... the security of Department of Defense assets and military cargo in the navigable waters of Puget Sound... Sound Waterways Management Division, Coast Guard; telephone 206-217-6045, email SectorPugetSound WWM...

  5. Upper extremity compartment syndrome in the setting of deep venous thrombosis and phlegmasia cerulea dolens: case report.

    Science.gov (United States)

    Bedri, Mazen I; Khosravi, Abtin H; Lifchez, Scott D

    2009-12-01

    Forearm compartment syndrome is an uncommon but emergent condition that can threaten limb and life. An uncommon cause of compartment syndrome is deep venous thrombosis, usually in the setting of phlegmasia cerulea dolens of the lower extremity. We present a case of compartment syndrome secondary to venous occlusion of the upper extremity due to phlegmasia cerulea dolens in a patient with metastatic lung cancer.

  6. Overview of Crane Control Systems and the Related Problems: Analysis of Container Oscillation Using Different Types of Cargoes

    Directory of Open Access Journals (Sweden)

    Tomas Eglynas

    2016-04-01

    Full Text Available Growing international trading increased cargo transportation in containers, therefore the port cranes have higher loads. Increased cargo flows can influence transportation safety. It is therefore necessary to review the crane systems and determine what factors might influence the volatility of the container and its cargo during transportation. The paper includes consideration and analysis of crane control systems and related problems. The authors consider the reasons of problems, probable damage and solution methods. The paper also provides the analysis of the relationship between different container cargoes and container oscillations occurring during handling operations using a container crane prototype. The analysis of the effect of different cargoes in containers on loading process and the results of occurring oscillations are presented.

  7. A delayed presentation of bilateral leg compartment syndrome following non-stop dancing.

    Science.gov (United States)

    Jefferies, James Gordon; Carter, Tom; White, Tim Oliver

    2015-03-18

    We present the case of a young man with a 48 h delayed presentation of bilateral lower limb acute compartment syndrome (ACS) affecting the anterior compartments following an extended period of dancing at a music festival. On making the diagnosis of ACS, the patient was immediately taken to theatre for fasciotomies and compartmental decompression. Repeat look fasciotomies revealed further necrosis to the muscles of the anterior compartments bilaterally and, effectively, all the muscle bellies within the anterior compartments were excised. The patient has been left with a significant functional deficit and disability. This case highlights the importance of timely diagnosis of ACS as delay in presentation can impact significantly on subsequent functional outcome and quality of life. 2015 BMJ Publishing Group Ltd.

  8. Stiffness and thickness of fascia do not explain chronic exertional compartment syndrome

    DEFF Research Database (Denmark)

    Dahl, Morten; Hansen, Philip; Stål, Per

    2011-01-01

    Chronic exertional compartment syndrome is diagnosed based on symptoms and elevated intramuscular pressure and often is treated with fasciotomy. However, what contributes to the increased intramuscular pressure remains unknown....

  9. Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis

    Directory of Open Access Journals (Sweden)

    Ivan Stupák

    2017-11-01

    Full Text Available Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract. In this work, we focused on the optimization of dissolution compartments/vessels for an updated version of the biorelevant dissolution apparatus—Golem v2. We designed eight compartments of uniform size but different inner geometry. The dissolution performance of the compartments was tested using immediate release caffeine tablets and evaluated by standard statistical methods and principal component analysis. Based on two phases of dissolution testing (using 250 and 100 mL of dissolution medium, we selected two compartment types yielding the highest measurement reproducibility. We also confirmed a statistically ssignificant effect of agitation rate and dissolution volume on the extent of drug dissolved and measurement reproducibility.

  10. Synchronous compartment temperature control and apparatus for refrigeration with reduced energy consumption

    Science.gov (United States)

    Gomes, Alberto Regio; Keres, Stephen L.; Kuehl, Stephen J.; Litch, Andrew D.; Richmond, Peter J.; Wu, Guolian

    2015-09-22

    A refrigerator appliance configuration, and associated methods of operation, for an appliance with a controller, a condenser, at least one evaporator, a compressor, and two refrigeration compartments. The configuration may be equipped with a variable-speed or variable-capacity compressor, variable speed evaporator or compartment fans, a damper and/or a dual-temperature evaporator with a valve system to control flow of refrigerant through one or more pressure reduction devices. The controller, by operation of the compressor, fans, damper and/or valve system, depending on the appliance configuration, controls the cooling rate in one or both compartments to synchronize, alternating cycles of cooling the compartments to their set point temperatures.

  11. Early procoagulant shift in the bronchoalveolar compartment of patients with secondary peritonitis

    NARCIS (Netherlands)

    van Till, J. W. Olivier; Levi, Marcel; Bresser, Paul; Schultz, Marcus J.; Gouma, Dirk J.; Boermeester, Marja A.

    2006-01-01

    BACKGROUND: In acute respiratory distress syndrome or pneumonia, a procoagulant shift is observed in bronchoalveolar lavage fluid (BALF). The effect of a primarily extrapulmonary infection on coagulation and fibrinolysis in the pulmonary compartment is unclear. METHODS: In 35 patients, 87

  12. Monitoring few molecular binding events in scalable confined aqueous compartments by raster image correlation spectroscopy (CADRICS).

    Science.gov (United States)

    Arrabito, G; Cavaleri, F; Montalbano, V; Vetri, V; Leone, M; Pignataro, B

    2016-11-29

    The assembly of scalable liquid compartments for binding assays in array formats constitutes a topic of fundamental importance in life sciences. This challenge can be addressed by mimicking the structure of cellular compartments with biological native conditions. Here, inkjet printing is employed to develop up to hundreds of picoliter aqueous droplet arrays stabilized by oil-confinement with mild surfactants (Tween-20). The aqueous environments constitute specialized compartments in which biomolecules may exploit their function and a wide range of molecular interactions can be quantitatively investigated. Raster Image Correlation Spectroscopy (RICS) is employed to monitor in each compartment a restricted range of dynamic intermolecular events demonstrated through protein-binding assays involving the biotin/streptavidin model system.

  13. Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers

    NARCIS (Netherlands)

    Tsvetkova, Yoanna; Beztsinna, Nataliia; Baues, Maike; Klein, Dionne; Rix, Anne; Golombek, Susanne K.; Al Rawashdeh, Wa'el; Gremse, Felix; Barz, Matthias; Koynov, Kaloian; Banala, Srinivas; Lederle, Wiltrud; Lammers, Twan; Kiessling, Fabian

    2017-01-01

    Riboflavin transporters (RFTs) and the riboflavin carrier protein (RCP) are highly upregulated in many tumor cells, tumor stem cells, and tumor neovasculature, which makes them attractive targets for nanomedicines. Addressing cells in different tumor compartments requires drug carriers, which are

  14. Shock Transmission Analyses of a Simplified Frigate Compartment Using LS-DYNA

    National Research Council Canada - National Science Library

    Trouwborst, W

    1999-01-01

    This report gives results as obtained with finite element analyses using the explicit finite element program LS-DYNA for a longitudinal slice of a frigate's compartment loaded with a shock pulse based...

  15. A surgical approach to the lateral compartment of the equine guttural pouch in the standing horse

    DEFF Research Database (Denmark)

    Muñoz, Juan A.; Stephen, Jennifer; Baptiste, Keith Edward

    2008-01-01

    The objective of this study was to evaluate the feasibility, efficacy and complications following lavage and drainage of the laterial compartment (LC) of the equine guttural pounch (GP) using a modified Garm´s technique (MGT)...

  16. Acute gluteal compartment syndrome: superior gluteal artery rupture following a low energy injury.

    Science.gov (United States)

    Smith, Aubrey; Chitre, Vivek; Deo, Hersh

    2012-12-17

    Acute compartment syndrome affecting the gluteal region is rare when compared to the same condition in the forearm or calf. When it does occur, it is usually due to prolonged immobilisation in those with altered consciousness. Gluteal compartment syndrome resulting from injury to the superior gluteal artery is extremely rare and to our knowledge has been described only twice--both after high-energy road traffic accidents (RTA). Other cases have described profound hypotension with superior gluteal artery injury after an RTA and falling off a horse, without acute gluteal compartment syndrome. We present a case of gluteal compartment syndrome due to rupture of the superior gluteal artery following a relatively minor fall. The patient required an emergency fasciotomy, which was performed within 4 h of the injury. This case highlights the importance of early diagnosis and treatment of this rare condition.

  17. Architectural properties of the neuromuscular compartments in selected forearm skeletal muscles.

    Science.gov (United States)

    Liu, An-Tang; Liu, Ben-Li; Lu, Li-Xuan; Chen, Gang; Yu, Da-Zhi; Zhu, Lie; Guo, Rong; Dang, Rui-Shan; Jiang, Hua

    2014-07-01

    The purposes f this study were to (i) explore the possibility of splitting the selected forearm muscles into separate compartments in human subjects; (ii) quantify the architectural properties of each neuromuscular compartment; and (iii) discuss the implication of these properties in split tendon transfer procedures. Twenty upper limbs from 10 fresh human cadavers were used in this study. Ten limbs of five cadavers were used for intramuscular nerve study by modified Sihler's staining technique, which confirmed the neuromuscular compartments. The other 10 limbs were included for architectural analysis of neuromuscular compartments. The architectural features of the compartments including muscle weight, muscle length, fiber length, pennation angle, and sarcomere length were determined. Physiological cross-sectional area and fiber length/muscle length ratio were calculated. Five of the selected forearm muscles were ideal candidates for splitting, including flexor carpi ulnaris, flexor carpi radials, extensor carpi radialis brevis, extensor carpi ulnaris and pronator teres. The humeral head of pronator teres contained the longest fiber length (6.23 ± 0.31 cm), and the radial compartment of extensor carpi ulnaris contained the shortest (2.90 ± 0.28 cm). The ulnar compartment of flexor carpi ulnaris had the largest physiological cross-sectional area (5.17 ± 0.59 cm(2)), and the ulnar head of pronator teres had the smallest (0.67 ± 0.06 cm(2)). Fiber length/muscle length ratios of the neuromuscular compartments were relatively low (average 0.27 ± 0.09, range 0.18-0.39) except for the ulnar head of pronator teres, which had the highest one (0.72 ± 0.05). Using modified Sihler's technique, this research demonstrated that each compartment of these selected forearm muscles has its own neurovascular supply after being split along its central tendon. Data of the architectural properties of each neuromuscular compartment provide insight into the 'design' of their

  18. Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies

    Directory of Open Access Journals (Sweden)

    Hua Li

    2015-08-01

    Full Text Available Cell-penetrating peptides (CPPs can cross cellular membranes in a non-toxic fashion, improving the intracellular delivery of various molecular cargos such as nanoparticles, small molecules and plasmid DNA. Because CPPs provide a safe, efficient, and non-invasive mode of transport for various cargos into cells, they have been developed as vectors for the delivery of genetic and biologic products in recent years. Most common CPPs are positively charged peptides. While delivering negatively charged molecules (e.g., nucleic acids to target cells, the internalization efficiency of CPPs is reduced and inhibited because the cationic charges on the CPPs are neutralized through the covering of CPPs by cargos on the structure. Even under these circumstances, the CPPs can still be non-covalently complexed with the negatively charged molecules. To address this issue, combination strategies of CPPs with other typical carriers provide a promising and novel delivery system. This review summarizes the latest research work in using CPPs combined with molecular cargos including liposomes, polymers, cationic peptides, nanoparticles, adeno-associated virus (AAV and calcium for the delivery of genetic products, especially for small interfering RNA (siRNA. This combination strategy remedies the reduced internalization efficiency caused by neutralization.

  19. 78 FR 64285 - National Maritime Strategy Symposium: Cargo Opportunities and Sealift Capacity

    Science.gov (United States)

    2013-10-28

    ... operates U.S.-flagged vessels. The purpose of this public meeting is to generate ideas that will improve... purpose of this public meeting is to gather ideas for improving the Nation's cargo opportunities and.... daily, January 14 through January 16, 2014. Key Date: The deadline to submit agenda topics and ideas for...

  20. Local synaptic signaling enhances the stochastic transport of motor-driven cargo in neurons

    KAUST Repository

    Newby, Jay

    2010-08-23

    The tug-of-war model of motor-driven cargo transport is formulated as an intermittent trapping process. An immobile trap, representing the cellular machinery that sequesters a motor-driven cargo for eventual use, is located somewhere within a microtubule track. A particle representing a motor-driven cargo that moves randomly with a forward bias is introduced at the beginning of the track. The particle switches randomly between a fast moving phase and a slow moving phase. When in the slow moving phase, the particle can be captured by the trap. To account for the possibility that the particle avoids the trap, an absorbing boundary is placed at the end of the track. Two local signaling mechanisms-intended to improve the chances of capturing the target-are considered by allowing the trap to affect the tug-of-war parameters within a small region around itself. The first is based on a localized adenosine triphosphate (ATP) concentration gradient surrounding a synapse, and the second is based on a concentration of tau-a microtubule-associated protein involved in Alzheimer\\'s disease-coating the microtubule near the synapse. It is shown that both mechanisms can lead to dramatic improvements in the capture probability, with a minimal increase in the mean capture time. The analysis also shows that tau can cause a cargo to undergo random oscillations, which could explain some experimental observations. © 2010 IOP Publishing Ltd.

  1. 46 CFR 154.705 - Cargo boil-off as fuel: General.

    Science.gov (United States)

    2010-10-01

    ... system must have a connection for introducing inert gas and for gas freeing the piping in the machinery space. (c) A gas fired main propulsion boiler or combustion engine must have a fuel oil fired pilot that... STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction and Equipment Cargo...

  2. The use of x-ray imaging technology in cargo inspection

    International Nuclear Information System (INIS)

    Palgan, Renato D.

    2009-01-01

    The aftermath of the September 11,2001 terrorist attack in the United States has brought a significant change in the conduct of trade and commerce among nations. The introduction on non-intrusive cargo inspection equipment, most x-ray and gamma ray scanners, among customs administrations worldwide has been widely employed and incorporated in their respective cargo examination procedures as part of their security initiative to deter terrorist threats. In compliance with our international commitment and agreement passed by the World Customs Organization which required the use of modern technology in cargo inspection, the Bureau of Customs had acquired 30 units of container x-ray scanners in 2006 from China that became operational in 2007 and the acquisition of which was guided by the following objectives: maximize collection of government revenues,facilitate trade and commerce, prevent smuggling, and safeguard the public and environment against the entry of hazardous and harmful substance. In this light, this paper discusses the brief background of the non-intrusive container inspection system project of the Bureau of Customs, an overview of the technical features of x-ray imaging technology acquired, the procedures in the application of x-ray inspection in containerized cargo, the radiation safety infrastructures and considerations, and a review of some major accomplishments after its two years of existence. (author)

  3. 19 CFR 123.92 - Electronic information for truck cargo required in advance of arrival.

    Science.gov (United States)

    2010-04-01

    ... foreign country. Cargo arriving by truck in transit through the United States from one foreign country to... point to another in the same foreign country (§ 123.31(b); § 123.42) are subject to the advance... complete name and address, or identification number, from the bill(s) of lading (for each house bill in a...

  4. Indications of marine bioinvasion from network theory. An analysis of the global cargo ship network

    NARCIS (Netherlands)

    Kölzsch, A.; Blasius, B.

    2011-01-01

    The transport of huge amounts of small aquatic organisms in the ballast tanks and at the hull of large cargo ships leads to ever increasing rates of marine bioinvasion. In this study, we apply a network theoretic approach to examine the introduction of invasive species into new ports by global

  5. Database specification for the Worldwide Port System (WPS) Regional Integrated Cargo Database (ICDB)

    Energy Technology Data Exchange (ETDEWEB)

    Faby, E.Z.; Fluker, J.; Hancock, B.R.; Grubb, J.W.; Russell, D.L. [Univ. of Tennessee, Knoxville, TN (United States); Loftis, J.P.; Shipe, P.C.; Truett, L.F. [Oak Ridge National Lab., TN (United States)

    1994-03-01

    This Database Specification for the Worldwide Port System (WPS) Regional Integrated Cargo Database (ICDB) describes the database organization and storage allocation, provides the detailed data model of the logical and physical designs, and provides information for the construction of parts of the database such as tables, data elements, and associated dictionaries and diagrams.

  6. Membrane-associated cargo recycling by tubule-based endosomal sorting

    NARCIS (Netherlands)

    van Weering, J.R.T.; Cullen, P.J.

    2014-01-01

    The endosome system is a collection of organelles that sort membrane-associated proteins and lipids for lysosomal degradation or recycling back to their target organelle. Recycling cargo is captured in a network of membrane tubules emanating from endosomes where tubular carriers pinch off. These

  7. 46 CFR 154.1325 - Liquid level alarm system: All cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... percent liquid full and without causing the pressure in the loading lines to exceed the design pressure... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction and... liquid level gauging system under § 154.1305; (b) Actuates quick-closing valves under §§ 154.530, 154.532...

  8. ESTIMATION OF EFFICIENCY OF INTERNATIONAL ECONOMIC RELATIONS IN INTERNATIONAL CARGO TRANSPORTATION BY ROAD

    Directory of Open Access Journals (Sweden)

    A. A. Kosovsky

    2006-01-01

    Full Text Available The paper proposes methodology for estimating efficiency international economic relations in the sphere international cargo transportation by road for the national economy on the basis of relationship between advantages and costs of sub-systems of the unified system for automotive export services.

  9. 33 CFR 155.1045 - Response plan requirements for vessels carrying oil as a secondary cargo.

    Science.gov (United States)

    2010-07-01

    ... spill and firefighting procedures for the oil cargo aboard the vessel. A material safety data sheet... GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION... percent if he or she submits historical data with the plan that substantiates the transfer of a lower...

  10. 75 FR 34573 - Bulk Solid Hazardous Materials: Harmonization With the International Maritime Solid Bulk Cargoes...

    Science.gov (United States)

    2010-06-17

    ... Pollution from Ships MISLE Marine Information for Safety and Law Enforcement MHB Materials Hazardous only in Bulk MSDS Material Safety Data Sheet NCB National Cargo Bureau NEPA National Environmental Policy Act... material safety data sheet (MSDS) address some portions of proposed Sec. 148.60. We agree with the comment...

  11. 77 FR 14327 - Bulk Packaging To Allow for Transfer of Hazardous Liquid Cargoes

    Science.gov (United States)

    2012-03-09

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 46 CFR Part 98 [Docket No. USCG-2011-0088] RIN 1625-AB63 Bulk Packaging To Allow for Transfer of Hazardous Liquid Cargoes AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard proposes to amend its regulations concerning the...

  12. Injuries sustained by passengers travelling in the cargo area of light ...

    African Journals Online (AJOL)

    a light delivery vehicle (LDV).[5,6] Injury prevention programmes ... Despite its inherently dangerous nature, the practice of transporting passengers in the cargo area of light delivery vehicles. (LDVs) is widespread in South ... event involved passengers being ejected from or falling out of an. LDV without a collision. Results.

  13. 49 CFR 180.413 - Repair, modification, stretching, rebarrelling, or mounting of specification cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Repair, modification, stretching, rebarrelling, or... Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS... of Cargo Tanks § 180.413 Repair, modification, stretching, rebarrelling, or mounting of specification...

  14. 75 FR 59617 - Notification of Arrival in U.S. Ports; Certain Dangerous Cargoes

    Science.gov (United States)

    2010-09-28

    ... definition. Because of this change, fewer vessels carrying only lower-risk cargoes will trigger NOA or other... CDC residue definition to include certain bulk liquids and liquefied gases in residue quantities, revise the definition of CDC to reflect the proposed change in the CDC residue definition, and adopt...

  15. 78 FR 57485 - Security Zone; Protection of Military Cargo, Captain of the Port Zone Puget Sound

    Science.gov (United States)

    2013-09-19

    ... Zone; Protection of Military Cargo, Captain of the Port Zone Puget Sound AGENCY: Coast Guard, DHS... Sound and adjacent waters. Entry into this zone is prohibited unless otherwise exempted or excluded... INFORMATION CONTACT: If you have questions on this notice, call or email LTJG Johnny Zeng, Sector Puget Sound...

  16. Rail freight vibration impact sleep and community response: An overview of CargoVibes

    NARCIS (Netherlands)

    Persson Waye, K.; Janssen, S.A.; Waddington, D.; Groll, W.; Croy, I.; Hammar, O.; Koopman, A.; Moorhouse, A.; Peris, E.; Sharp, C.; Sica, G.; Smith, M.G.; Vos, H.; Woodcock, J.; Ogren, M.

    2014-01-01

    The European Union funded project: CargoVibes involving ten partners from eight nations has aimed to examine ground-borne vibration affecting residents close to freight railway lines. The paper presents an overview of the work package investigating human response to vibration, with particular focus

  17. Injuries sustained by passengers travelling in the cargo area of light ...

    African Journals Online (AJOL)

    All patients presenting to the Pietermaritzburg Metropolitan Trauma Service in KwaZulu-Natal Province following an event in which they had been travelling in the cargo area of an LDV between January 2011 and December 2012 were included in the audit. Results. A total of 66 patients were treated during the study period; ...

  18. 77 FR 21579 - Agency Information Collection Activities: Transfer of Cargo to a Container Station

    Science.gov (United States)

    2012-04-10

    ... Activities: Transfer of Cargo to a Container Station AGENCY: U.S. Customs and Border Protection, Department... a Container Station. This is a proposed extension of an information collection that was previously... Container Station. OMB Number: 1651-0096. Form Number: None. Abstract: Before the filing of an entry of...

  19. 19 CFR 122.48a - Electronic information for air cargo required in advance of arrival.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Electronic information for air cargo required in... OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  20. Tracking 800-year-old Shipments: An Archaeological Investigation of the Mado Shipwreck Cargo, Taean, Korea

    Science.gov (United States)

    Kim, Minkoo; Moon, Whan Suk

    2011-12-01

    This paper examines cargo from an 800-year-old shipwreck and discusses its implications in relation to the exchange networks and maritime transportation of the Goryeo period (A.D. 918-1392) in Korea. In 2007, two local fishermen fortuitously discovered porcelain vessels from a Goryeo-period shipwreck off the mid-western coast of the Korean peninsula. Underwater excavation conducted by the National Research Institute of Maritime Cultural Heritage (NRIMCH) revealed that the ship was carrying a myriad of cargoes destined for Gaegyeong, the capital of the Goryeo dynasty. Excavation indicates that the main body of the cargo was porcelain vessels produced in the southern part of the peninsula. Archaeobotanical investigation of the wreck deposits revealed that the ship was carrying crops such as rice ( Oryza sativa L.), broomcorn millet ( Panicum miliaceum L.), foxtail millet ( Setaria italica (L.) P. Beauv.), and buckwheat ( Fagopyrum esculentum Moench) bound for the capital. Among the recovered objects were 73 wooden cargo tags with Chinese letters. These tags, equivalent to the modern day air bill, contained detailed information about the senders, recipients, and shipped goods. These findings indicate that during the Goryeo period maritime transportation played an important role in the interpersonal exchange of products over long distances.

  1. Myosin-V opposes microtubule-based cargo transport and drives directional motility on cortical actin.

    Science.gov (United States)

    Kapitein, Lukas C; van Bergeijk, Petra; Lipka, Joanna; Keijzer, Nanda; Wulf, Phebe S; Katrukha, Eugene A; Akhmanova, Anna; Hoogenraad, Casper C

    2013-05-06

    Intracellular transport is driven by motor proteins that either use microtubules or actin filaments as their tracks, but the interplay between these transport pathways is poorly understood. Whereas many microtubule-based motors are known to drive long-range transport, several actin-based motors have been proposed to function predominantly in cargo tethering. How these opposing activities are integrated on cargoes that contain both types of motors is unknown. Here we use inducible intracellular transport assays to show that acute recruitment of myosin-V to kinesin-propelled cargo reduces their motility near the cell periphery and enhances their localization at the actin-rich cell cortex. Myosin-V arrests rapid microtubule-based transport without the need for regulated auto- or other inhibition of kinesin motors. In addition, myosin-V, despite being an ineffective long-range transporter, can drive slow, medium-range (1-5 μm), point-to-point transport in cortical cell regions. Altogether, these data support a model in which myosin-V establishes local cortical delivery of kinesin-bound cargos through a combination of tethering and active transport. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Gluteal compartment syndrome following drug-induced immobilization: a case report

    OpenAIRE

    Panagiotopoulos, Andreas Christos; Vrachnis, Ioannis; Kraniotis, Pantelis; Tyllianakis, Minos

    2015-01-01

    Background Gluteal compartment syndrome is a very rare condition characterized by non-specific symptoms that often lead to misdiagnosis. Case presentation We report a case of gluteal compartment syndrome in a 38?year-old Caucasian male (intravenous drug user) following prolonged immobilization due to loss of consciousness. The delay in the appropriate diagnosis and treatment led to a temporary acute kidney injury and to irreversible sciatic nerve palsy. Conclusion Delay in the definitive diag...

  3. CHRONIC COMPARTMENT SYNDROME OF LOWER LEG. AN UNUSUAL CASE IN NON ATHLETIC PATIENT.

    Directory of Open Access Journals (Sweden)

    Andrea Schiavone

    2016-10-01

    Full Text Available Chronic exertional anterior compartment syndrome is debilitating disease of lower limb. The clinical picture is characterised by limited symptomology at rest, pain during sporting activities, tumefaction and contractures of limb as well impotency by pain of the entire forefoot and hypoesthesia. Usually the most affected patients are athletes. We analyse a case of chronic post traumatic compartment syndrome of the anterior tibial muscle in an unsportsmanlike patient.

  4. Bilateral calf chronic compartment syndrome in an elderly male: a case report.

    LENUS (Irish Health Repository)

    Siau, Keith

    2009-01-01

    Leg pain is a common presentation to the outpatient department. Bilateral calf chronic compartment syndrome is a rare cause of bilateral calf pain. Although this condition has been well documented in young athletes, it has rarely been reported in the elderly. We present the case of a 68-year-old male bodybuilder with bilateral calf chronic compartment syndrome, describe the presentation and evaluation of the condition, and provide a review of the literature herewith.

  5. Development of a compartment model based on CFD simulations for description of mixing in bioreactors

    Directory of Open Access Journals (Sweden)

    Crine, M.

    2010-01-01

    Full Text Available Understanding and modeling the complex interactions between biological reaction and hydrodynamics are a key problem when dealing with bioprocesses. It is fundamental to be able to accurately predict the hydrodynamics behavior of bioreactors of different size and its interaction with the biological reaction. CFD can provide detailed modeling about hydrodynamics and mixing. However, it is computationally intensive, especially when reactions are taken into account. Another way to predict hydrodynamics is the use of "Compartment" or "Multi-zone" models which are much less demanding in computation time than CFD. However, compartments and fluxes between them are often defined by considering global quantities not representative of the flow. To overcome the limitations of these two methods, a solution is to combine compartment modeling and CFD simulations. Therefore, the aim of this study is to develop a methodology in order to propose a compartment model based on CFD simulations of a bioreactor. The flow rate between two compartments can be easily computed from the velocity fields obtained by CFD. The difficulty lies in the definition of the zones in such a way they can be considered as perfectly mixed. The creation of the model compartments from CFD cells can be achieved manually or automatically. The manual zoning consists in aggregating CFD cells according to the user's wish. The automatic zoning defines compartments as regions within which the value of one or several properties are uniform with respect to a given tolerance. Both manual and automatic zoning methods have been developed and compared by simulating the mixing of an inert scalar. For the automatic zoning, several algorithms and different flow properties have been tested as criteria for the compartment creation.

  6. The longest telomeres: a general signature of adult stem cell compartments

    Science.gov (United States)

    Flores, Ignacio; Canela, Andres; Vera, Elsa; Tejera, Agueda; Cotsarelis, George; Blasco, María A.

    2008-01-01

    Identification of adult stem cells and their location (niches) is of great relevance for regenerative medicine. However, stem cell niches are still poorly defined in most adult tissues. Here, we show that the longest telomeres are a general feature of adult stem cell compartments. Using confocal telomere quantitative fluorescence in situ hybridization (telomapping), we find gradients of telomere length within tissues, with the longest telomeres mapping to the known stem cell compartments. In mouse hair follicles, we show that cells with the longest telomeres map to the known stem cell compartments, colocalize with stem cell markers, and behave as stem cells upon treatment with mitogenic stimuli. Using K15-EGFP reporter mice, which mark hair follicle stem cells, we show that GFP-positive cells have the longest telomeres. The stem cell compartments in small intestine, testis, cornea, and brain of the mouse are also enriched in cells with the longest telomeres. This constitutes the description of a novel general property of adult stem cell compartments. Finally, we make the novel finding that telomeres shorten with age in different mouse stem cell compartments, which parallels a decline in stem cell functionality, suggesting that telomere loss may contribute to stem cell dysfunction with age. PMID:18283121

  7. Application of separable parameter space techniques to multi-tracer PET compartment modeling.

    Science.gov (United States)

    Zhang, Jeff L; Michael Morey, A; Kadrmas, Dan J

    2016-02-07

    Multi-tracer positron emission tomography (PET) can image two or more tracers in a single scan, characterizing multiple aspects of biological functions to provide new insights into many diseases. The technique uses dynamic imaging, resulting in time-activity curves that contain contributions from each tracer present. The process of separating and recovering separate images and/or imaging measures for each tracer requires the application of kinetic constraints, which are most commonly applied by fitting parallel compartment models for all tracers. Such multi-tracer compartment modeling presents challenging nonlinear fits in multiple dimensions. This work extends separable parameter space kinetic modeling techniques, previously developed for fitting single-tracer compartment models, to fitting multi-tracer compartment models. The multi-tracer compartment model solution equations were reformulated to maximally separate the linear and nonlinear aspects of the fitting problem, and separable least-squares techniques were applied to effectively reduce the dimensionality of the nonlinear fit. The benefits of the approach are then explored through a number of illustrative examples, including characterization of separable parameter space multi-tracer objective functions and demonstration of exhaustive search fits which guarantee the true global minimum to within arbitrary search precision. Iterative gradient-descent algorithms using Levenberg-Marquardt were also tested, demonstrating improved fitting speed and robustness as compared to corresponding fits using conventional model formulations. The proposed technique overcomes many of the challenges in fitting simultaneous multi-tracer PET compartment models.

  8. Origins of Common Neural Inputs to Different Compartments of the Extensor Digitorum Communis Muscle.

    Science.gov (United States)

    Dai, Chenyun; Shin, Henry; Davis, Bradley; Hu, Xiaogang

    2017-10-24

    The extensor digitorum communis (EDC) is a multi-compartment muscle that allows dexterous extension of the four digits. However, the level of common input shared across different compartments of this muscle is not well understood. We seek to systematically characterize the common and independent neural input, originated from different levels of the central nervous system, to the different compartments. A motor unit (MU) coherence analysis was used to capture the different sources of common and independent input, by quantifying the coherence of MU discharge between different compartments. The MU activities were obtained from decomposition of surface electromyogram recordings. Our results showed that the MU coherence across different muscle compartments accounted for only a small proportion (60%) in the delta (1-4 Hz) band. Additionally, cross-compartment coherence between the middle and ring-little fingers tended to be higher as compared with other finger combinations. Overall, the common input shared across different fingers are found to be at low to moderate levels, in comparison with the total input, which allows dexterous control of individual digits with some degree of coordinated control of multiple digits.

  9. Application of separable parameter space techniques to multi-tracer PET compartment modeling

    Science.gov (United States)

    Zhang, Jeff L.; Morey, A. Michael; Kadrmas, Dan J.

    2016-02-01

    Multi-tracer positron emission tomography (PET) can image two or more tracers in a single scan, characterizing multiple aspects of biological functions to provide new insights into many diseases. The technique uses dynamic imaging, resulting in time-activity curves that contain contributions from each tracer present. The process of separating and recovering separate images and/or imaging measures for each tracer requires the application of kinetic constraints, which are most commonly applied by fitting parallel compartment models for all tracers. Such multi-tracer compartment modeling presents challenging nonlinear fits in multiple dimensions. This work extends separable parameter space kinetic modeling techniques, previously developed for fitting single-tracer compartment models, to fitting multi-tracer compartment models. The multi-tracer compartment model solution equations were reformulated to maximally separate the linear and nonlinear aspects of the fitting problem, and separable least-squares techniques were applied to effectively reduce the dimensionality of the nonlinear fit. The benefits of the approach are then explored through a number of illustrative examples, including characterization of separable parameter space multi-tracer objective functions and demonstration of exhaustive search fits which guarantee the true global minimum to within arbitrary search precision. Iterative gradient-descent algorithms using Levenberg-Marquardt were also tested, demonstrating improved fitting speed and robustness as compared to corresponding fits using conventional model formulations. The proposed technique overcomes many of the challenges in fitting simultaneous multi-tracer PET compartment models.

  10. Differential activity of Drosophila Hox genes induces myosin expression and can maintain compartment boundaries.

    Directory of Open Access Journals (Sweden)

    Jesús R Curt

    Full Text Available Compartments are units of cell lineage that subdivide territories with different developmental potential. In Drosophila, the wing and haltere discs are subdivided into anterior and posterior (A/P compartments, which require the activity of Hedgehog, and into dorsal and ventral (D/V compartments, needing Notch signaling. There is enrichment in actomyosin proteins at the compartment boundaries, suggesting a role for these proteins in their maintenance. Compartments also develop in the mouse hindbrain rhombomeres, which are characterized by the expression of different Hox genes, a group of genes specifying different structures along their main axis of bilaterians. We show here that the Drosophila Hox gene Ultrabithorax can maintain the A/P and D/V compartment boundaries when Hedgehog or Notch signaling is compromised, and that the interaction of cells with and without Ultrabithorax expression induces high levels of non-muscle myosin II. In the absence of Ultrabithorax there is occasional mixing of cells from different segments. We also show a similar role in cell segregation for the Abdominal-B Hox gene. Our results suggest that the juxtaposition of cells with different Hox gene expression leads to their sorting out, probably through the accumulation of non-muscle myosin II at the boundary of the different cell territories. The increase in myosin expression seems to be a general mechanism used by Hox genes or signaling pathways to maintain the segregation of different groups of cells.

  11. Hadron calorimeter performance with a PbWO4 EM compartment

    Energy Technology Data Exchange (ETDEWEB)

    Green, D.

    1996-01-01

    The CMS detector[1] at the LHC has chosen PbWO4 in order to achieve the superior photon energy resolution which is crucial in searching for the 2 photon decay of low mass Higgs bosons. The hadronic compartment is thought to be Cu absorber, since one is immersed in a 4 T magnetic field, read out by scintillator tiles coupled to wavelength shifter (WLS) fibers. The combined performance of this calorimeter is of interest in the study of jets and missing transverse energy (neutrino, SUSY signatures). For this reason, a test was made of the electromagnetic (EM) compartment combined with a reasonable approximation to the baseline HCAL ``barrel`` calorimeter. Data was taken in the H4 CERN beamline. The EM compartment was a 7 {times} 7 square array of PbWO4 crystals, which for the purposes of this study are considered as a single readout in depth (or ``compartment``) [2]. The HCAL module consisted of large scintillator plates with 24 individual longitudinal readout channels. The EM compartment was followed by 10 Cu plates each 3 cm thick, followed by 9 Cu plates each 6 cm thick. This set of absorber plates represented the HCAL compartments inside the coil. The coil itself [1] was approximated as Al and Fe plates, of a total thickness of about 1.4 absorption lengths. The coil mockup was sampled and then followed by 4 plates of 8 cm thick Cu, each with an individual readout which represented a test of the ``Tailcatcher`` concept.

  12. Application of separable parameter space techniques to multi-tracer PET compartment modeling

    International Nuclear Information System (INIS)

    Zhang, Jeff L; Michael Morey, A; Kadrmas, Dan J

    2016-01-01

    Multi-tracer positron emission tomography (PET) can image two or more tracers in a single scan, characterizing multiple aspects of biological functions to provide new insights into many diseases. The technique uses dynamic imaging, resulting in time-activity curves that contain contributions from each tracer present. The process of separating and recovering separate images and/or imaging measures for each tracer requires the application of kinetic constraints, which are most commonly applied by fitting parallel compartment models for all tracers. Such multi-tracer compartment modeling presents challenging nonlinear fits in multiple dimensions. This work extends separable parameter space kinetic modeling techniques, previously developed for fitting single-tracer compartment models, to fitting multi-tracer compartment models. The multi-tracer compartment model solution equations were reformulated to maximally separate the linear and nonlinear aspects of the fitting problem, and separable least-squares techniques were applied to effectively reduce the dimensionality of the nonlinear fit. The benefits of the approach are then explored through a number of illustrative examples, including characterization of separable parameter space multi-tracer objective functions and demonstration of exhaustive search fits which guarantee the true global minimum to within arbitrary search precision. Iterative gradient-descent algorithms using Levenberg–Marquardt were also tested, demonstrating improved fitting speed and robustness as compared to corresponding fits using conventional model formulations. The proposed technique overcomes many of the challenges in fitting simultaneous multi-tracer PET compartment models. (paper)

  13. Body fat measurement among Singaporean Chinese, Malays and Indians: a comparative study using a four-compartment model and different two-compartment models

    NARCIS (Netherlands)

    Deurenberg-Yap, M.; Schmidt, G.; Staveren, van W.A.; Hautvast, J.G.A.J.; Deurenberg, P.

    2001-01-01

    This cross-sectional study compared body fat percentage (BF€obtained from a four-compartment (4C) model with BF␏rom hydrometry (using 2H2O), dual-energy X-ray absorptiometry (DXA) and densitometry among the three main ethnic groups (Chinese, Malays and Indians) in Singapore, and determined the

  14. Focuss algorithm application in kinetic compartment modeling for PET tracer

    International Nuclear Information System (INIS)

    Huang Xinrui; Bao Shanglian

    2004-01-01

    Molecular imaging is in the process of becoming. Its application mostly depends on the molecular discovery process of imaging probes and drugs, from the mouse to the patient, from research to clinical practice. Positron emission tomography (PET) can non-invasively monitor . pharmacokinetic and functional processes of drugs in intact organisms at tracer concentrations by kinetic modeling. It has been known that for all biological systems, linear or nonlinear, if the system is injected by a tracer in a steady state, the distribution of the tracer follows the kinetics of a linear compartmental system, which has sums of exponential solutions. Based on the general compartmental description of the tracer's fate in vivo, we presented a novel kinetic modeling approach for the quantification of in vivo tracer studies with dynamic positron emission tomography (PET), which can determine a parsimonious model consisting with the measured data. This kinetic modeling technique allows for estimation of parametric images from a voxel based analysis and requires no a priori decision about the tracer's fate in vivo, instead determining the most appropriate model from the information contained within the kinetic data. Choosing a set of exponential functions, convolved with the plasma input function, as basis functions, the time activity curve of a region or a pixel can be written as a linear combination of the basis functions with corresponding coefficients. The number of non-zero coefficients returned corresponds to the model order which is related to the number of tissue compartments. The system macro parameters are simply determined using the focal underdetermined system solver (FOCUSS) algorithm. The FOCUSS algorithm is a nonparametric algorithm for finding localized energy solutions from limited data and is a recursive linear estimation procedure. FOCUSS algorithm usually converges very fast, so demands a few iterations. The effectiveness is verified by simulation and clinical

  15. Search for and characterization of microorganisms in deep geological compartments

    International Nuclear Information System (INIS)

    Barsotti, Vanessa

    2011-01-01

    Over the past 50 years, the scientific community has shown a growing interest for deep geological compartments. However, these ecosystems remain largely unknown due to their inaccessibility. The aim of the present thesis was double; the first aim was to characterize, from a microbiological perspective, four terrestrial Triassic sedimentary formations located between 1700 and 2000 m depth in the Parisian Basin and collected by the ANDRA during a deep drilling campaign in 2008, and the second aim was to study the combined effects of temperature, pressure and salinity on the metabolic activity of anaerobic prokaryotes in order to predict their reaction to geological burial. Incubations in a large variety of media were carried out in order to stimulate the growth of the main trophic types found in such environments such as methanogens, fermenters and bacteria reducing sulphur compounds, however, no viable and cultivable microorganisms could be isolated. In parallel, a molecular approach was used to i) compare the efficacy of several DNA extractions methods and ii) analyse the bacterial diversity, using DGGE (Denaturing Gel Gradient Electrophoresis) and cloning, present in rock inner cores conserved either at atmospheric pressure or under pressure, in their initial states and following incubations in various media. The genetic exploration of these samples revealed a very low biomass and a poor diversity composed mainly of aerobic and mesophilic members of the Bacteria domain, a priori unadapted to such a deep, hot, saline and anoxic environment. This unexpected microbial community also found in many subsurface ecosystems as well as in extreme ecosystems could have partially originated from a paleo-recharge of the Trias aquifer with cold waters coming from the melting of ice formed during the last Pleistocene glaciation. The second objective was to study the combined effects of temperature (40, 55 and 70 C), pressure (1, 90 and 180 bars) and salinity (13, 50, 110, 180

  16. Multi-energy x-ray detectors to improve air-cargo security

    Science.gov (United States)

    Paulus, Caroline; Moulin, Vincent; Perion, Didier; Radisson, Patrick; Verger, Loïck

    2017-05-01

    X-ray based systems have been used for decades to screen luggage or cargo to detect illicit material. The advent of energy-sensitive photon-counting x-ray detectors mainly based on Cd(Zn)Te semi-conductor technology enables to improve discrimination between materials compared to single or dual energy technology. The presented work is part of the EUROSKY European project to develop a Single European Secure Air-Cargo Space. "Cargo" context implies the presence of relatively heavy objects and with potentially high atomic number. All the study is conducted on simulations with three different detectors: a typical dual energy sandwich detector, a realistic model of the commercial ME100 multi-energy detector marketed by MULTIX, and a ME100 "Cargo": a not yet existing modified multi-energy version of the ME100 more suited to air freight cargo inspection. Firstly, a comparison on simulated measurements shows the performances improvement of the new multi-energy detectors compared to the current dual-energy one. The relative performances are evaluated according to different criteria of separability or contrast-to-noise ratio and the impact of different parameters is studied (influence of channel number, type of materials and tube voltage). Secondly, performances of multi-energy detectors for overlaps processing in a dual-view system is accessed: the case of orthogonal projections has been studied, one giving dimensional values, the other one providing spectral data to assess effective atomic number. A method of overlap correction has been proposed and extended to multi-layer objects case. Therefore, Calibration and processing based on bi-material decomposition have been adapted for this purpose.

  17. 46 CFR 32.50-5 - Cargo pump gauges on tank vessels constructed on or after November 10, 1936-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo pump gauges on tank vessels constructed on or... SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Pumps, Piping, and Hose for Cargo Handling § 32.50-5 Cargo pump gauges on tank vessels constructed on or after November 10, 1936—TB/ALL. (a...

  18. 46 CFR 32.50-1 - Cargo pumps for tank vessels constructed on or after November 10, 1936-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo pumps for tank vessels constructed on or after... TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Pumps, Piping, and Hose for Cargo Handling § 32.50-1 Cargo pumps for tank vessels constructed on or after November 10, 1936—TB/ALL. On all...

  19. 46 CFR 32.50-25 - Cargo pumps and piping on tank vessels constructed prior to November 10, 1936-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo pumps and piping on tank vessels constructed prior... SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Pumps, Piping, and Hose for Cargo Handling § 32.50-25 Cargo pumps and piping on tank vessels constructed prior to November 10, 1936—TB/ALL...

  20. 46 CFR 153.372 - Gauges and vapor return for cargo vapor pressures exceeding 100 kPa (approx. 14.7 psia).

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Gauges and vapor return for cargo vapor pressures... COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Venting Systems § 153.372 Gauges and vapor... section, the containment system must have a: (a) Tank pressure gauge at the point where cargo flow is...