Sample records for care nap sacc

  1. Advanced Stellar Compass, SAC-C, Interface Control Document

    DEFF Research Database (Denmark)

    Madsen, Peter Buch; Betto, Maurizio; Riis, Troels;

    Interface Control Document for the Advanced Stellar Compass for the SAC-C satellite. The SAC-C is Argentine, Danish and NASA satellite. On the SAC-C satellite there are a simplified version of the Ørsted instrumentation platform. The Advanced Stellar Compass is a improved version of the Ørsted Star...... Imager. This document descibes the interface between the Advanced Stellar Compass and OBDH, the size of the DPU and the Camera etc....

  2. Naps (For Parents) (United States)

    ... age-by-age guidelines give an idea of average daily sleep requirements: Birth to 6 months: Infants require about ... Toddlers generally require 12 to 14 hours of sleep, including an afternoon nap ... (3 to 5 years): Preschoolers average about 11 to 12 hours at night, plus ...

  3. Unit 6 Nap Time

    Institute of Scientific and Technical Information of China (English)


    <正> Story: After a busy morning,it is time for a little rest."It’s nap time. Take off your shoes,"says Miss Grant. She helps everyone get their sleeping bags and makes sure that everyone has put their shoes outside Before everyone falls asleep they ask the teacher," Read us a story, please."

  4. Baby Naps: Daytime Sleep Tips (United States)

    ... of sudden infant death syndrome: Diagnostic coding shifts, controversies regarding the sleeping environment, and new variables to ... infant-and-toddler-health/in-depth/baby-naps/art-20047421 . Mayo Clinic Footer Legal Conditions and Terms ...

  5. Polyphasic Sleep and Napping Strategies (United States)


    UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADPO10471 TITLE: Polyphasic Sleep and Napping Strategies UNCLASSIFIED hfollowing comonent part numbers A cnprie the 0com ilation report- ADP010453 thru. ADP010473 20-1 Polyphasic Sleep and Napping ... Strategies Per Kristian OPSTAD Norwegian Defence Research Establishment P 0 Box 25 2027 Kjeller Norway Sleep deprivation is the most detrimental The

  6. Documentation for delivery of Star Tracker to SAC-C

    DEFF Research Database (Denmark)

    Kilsgaard, Søren; Thuesen, Gøsta; Riis, Troels;


    The documentation EIDP (End Item Data Package) describes all the tests which have been performed on the flight hardware of the Star Tracker for the Argentine, Danish and NASA satellite SAC-C.......The documentation EIDP (End Item Data Package) describes all the tests which have been performed on the flight hardware of the Star Tracker for the Argentine, Danish and NASA satellite SAC-C....

  7. Napping and Human Functioning during Prolonged Work (United States)


    alternative to napping is prolonged wakefulness. Polyphasic sleep , with frequent naps rather than a single sleep period per 24 hours, is natural for both the...very young and for the aged. It is not practiced by most adults, perhaps because of societal demands. Possibly a polyphasic sleep schedule could be...Functioning 1.2 Scope of this Chapter 2. REVIEW OF LITERATURE 2.1 Partial Sleep Deprivation Studies 2.2 Nap Studies: Four Nap Factors Affecting Performance

  8. Alertness management in flight operations - Strategic napping (United States)

    Rosekind, Mark R.; Gander, Philippa H.; Dinges, David F.


    Strategic napping in two different flight operation environments is considered to illustrate its application as a fatigue countermeasure. Data obtained from commercial short-haul and long-haul operations demonstrated the utility and current practices of strategic napping. A preplanned cockpit nap acted as an acute 'safety valve' for the sleep loss, circadian disruption, and fatigue that occurs in long-haul flying.

  9. Periplasmic nitrate reduction in Wolinella succinogenes: cytoplasmic NapF facilitates NapA maturation and requires the menaquinol dehydrogenase NapH for membrane attachment. (United States)

    Kern, Melanie; Simon, Jörg


    Various nitrate-reducing bacteria produce proteins of the periplasmic nitrate reductase (Nap) system to catalyse electron transport from the membraneous quinol pool to the periplasmic nitrate reductase NapA. The composition of the corresponding nap gene clusters varies but, in addition to napA, genes encoding at least one membrane-bound quinol dehydrogenase module (NapC and/or NapGH) are regularly present. Moreover, some nap loci predict accessory proteins such as the iron-sulfur protein NapF, whose function is poorly understood. Here, the role of NapF in nitrate respiration of the Epsilonproteobacterium Wolinella succinogenes was examined. Immunoblot analysis showed that NapF is located in the membrane fraction in nitrate-grown wild-type cells whereas it was found to be a soluble cytoplasmic protein in a napH deletion mutant. This finding indicates the formation of a membrane-bound NapGHF complex that is likely to catalyse NapH-dependent menaquinol oxidation and electron transport to the iron-sulfur adaptor proteins NapG and NapF, which are located on the periplasmic and cytoplasmic side of the membrane, respectively. The cysteine residues of a CX(3)CP motif and of the C-terminal tetra-cysteine cluster of NapH were found to be required for interaction with NapF. A napF deletion mutant accumulated the catalytically inactive cytoplasmic NapA precursor, suggesting that electron flow or direct interaction between NapF and NapA facilitated NapA assembly and/or export. On the other hand, NapA maturation and activity was not impaired in the absence of NapH, demonstrating that soluble NapF is functional. Each of the four tetra-cysteine motifs of NapF was modified but only one motif was found to be essential for efficient NapA maturation. It is concluded that the NapGHF complex plays a multifunctional role in menaquinol oxidation, electron transfer to periplasmic NapA and maturation of the cytoplasmic NapA precursor.

  10. Daytime nap controls toddlers’ nighttime sleep (United States)

    Nakagawa, Machiko; Ohta, Hidenobu; Nagaoki, Yuko; Shimabukuro, Rinshu; Asaka, Yoko; Takahashi, Noriko; Nakazawa, Takayo; Kaneshi, Yousuke; Morioka, Keita; Oishi, Yoshihisa; Azami, Yuriko; Ikeuchi, Mari; Takahashi, Mari; Hirata, Michio; Ozawa, Miwa; Cho, Kazutoshi; Kusakawa, Isao; Yoda, Hitoshi


    Previous studies have demonstrated that afternoon naps can have a negative effect on subsequent nighttime sleep in children. These studies have mainly been based on sleep questionnaires completed by parents. To investigate the effect of napping on such aspects of sleep quality, we performed a study in which child activity and sleep levels were recorded using actigraphy. The parents were asked to attach actigraphy units to their child’s waist by an adjustable elastic belt and complete a sleep diary for 7 consecutive days. 50 healthy young toddlers of approximately 1.5 years of age were recruited. There was a significant negative correlation between nap duration and both nighttime sleep duration and sleep onset time, suggesting that long nap sleep induces short nighttime sleep duration and late sleep onset time. We also found a significant negative correlation between nap timing and nighttime sleep duration and also a significant positive correlation between nap timing and sleep onset time, suggesting that naps in the late afternoon also lead to short nighttime sleep duration and late sleep onset. Our findings suggest that duration-controlled naps starting early in the afternoon can induce a longer nighttime sleep in full-term infants of approximately 1.5 years of age. PMID:27277329

  11. Daydreams and nap dreams: Content comparisons. (United States)

    Carr, Michelle; Nielsen, Tore


    Differences between nighttime REM and NREM dreams are well-established but only rarely are daytime REM and NREM nap dreams compared with each other or with daydreams. Fifty-one participants took daytime naps (with REM or NREM awakenings) and provided both waking daydream and nap dream reports. They also provided ratings of their bizarreness, sensory experience, and emotion intensity. Recall rates for REM (96%) and NREM (89%) naps were elevated compared to typical recall rates for nighttime dreams (80% and 43% respectively), suggesting an enhanced circadian influence. All attribute ratings were higher for REM than for NREM dreams, replicating findings for nighttime dreams. Compared with daydreams, NREM dreams had lower ratings for emotional intensity and sensory experience while REM dreams had higher ratings for bizarreness and sensory experience. Results support using daytime naps in dream research and suggest that there occurs selective enhancement and inhibition of specific dream attributes by REM, NREM and waking state mechanisms.

  12. Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model. (United States)

    Vaisburd, Sinaya; Shemer, Zeev; Yeheskel, Adva; Giladi, Eliezer; Gozes, Illana


    Mutated disrupted in schizophrenia 1 (DISC1), a microtubule regulating protein, leads to schizophrenia and other psychiatric illnesses. It is hypothesized that microtubule stabilization may provide neuroprotection in schizophrenia. The NAP (NAPVSIPQ) sequence of activity-dependent neuroprotective protein (ADNP) contains the SxIP motif, microtubule end binding (EB) protein target, which is critical for microtubule dynamics leading to synaptic plasticity and neuroprotection. Bioinformatics prediction for FDA approved drugs mimicking SxIP-like motif which displace NAP-EB binding identified Risperidone. Risperidone or NAP effectively ameliorated object recognition deficits in the mutated DISC1 mouse model. NAP but not Risperidone, reduced anxiety in the mutated mice. Doxycycline, which blocked the expression of the mutated DISC1, did not reverse the phenotype. Transcripts of Forkhead-BOX P2 (Foxp2), a gene regulating DISC1 and associated with human ability to acquire a spoken language, were increased in the hippocampus of the DISC1 mutated mice and were significantly lowered after treatment with NAP, Risperidone, or the combination of both. Thus, the combination of NAP and standard of care Risperidone in humans may protect against language disturbances associated with negative and cognitive impairments in schizophrenia.

  13. Naps May Sharpen a Preschooler's Language Skills (United States)

    ... fullstory_163510.html Naps May Sharpen a Preschooler's Language Skills Kids who slept after learning new verbs understood ... have an advantage when it comes to developing language skills, a new study suggests. Researchers assessed 39 youngsters ...

  14. The association between daytime napping and cognitive functioning in chronic fatigue syndrome.

    Directory of Open Access Journals (Sweden)

    Zoe M Gotts

    Full Text Available The precise relationship between sleep and physical and mental functioning in chronic fatigue syndrome (CFS has not been examined directly, nor has the impact of daytime napping. This study aimed to examine self-reported sleep in patients with CFS and explore whether sleep quality and daytime napping, specific patient characteristics (gender, illness length and levels of anxiety and depression, predicted daytime fatigue severity, levels of daytime sleepiness and cognitive functioning, all key dimensions of the illness experience.118 adults meeting the 1994 CDC case criteria for CFS completed a standardised sleep diary over 14 days. Momentary functional assessments of fatigue, sleepiness, cognition and mood were completed by patients as part of usual care. Levels of daytime functioning and disability were quantified using symptom assessment tools, measuring fatigue (Chalder Fatigue Scale, sleepiness (Epworth Sleepiness Scale, cognitive functioning (Trail Making Test, Cognitive Failures Questionnaire, and mood (Hospital Anxiety and Depression Scale.Hierarchical Regressions demonstrated that a shorter time since diagnosis, higher depression and longer wake time after sleep onset predicted 23.4% of the variance in fatigue severity (p <.001. Being male, higher depression and more afternoon naps predicted 25.6% of the variance in objective cognitive dysfunction (p <.001. Higher anxiety and depression and morning napping predicted 32.2% of the variance in subjective cognitive dysfunction (p <.001. When patients were classified into groups of mild and moderate sleepiness, those with longer daytime naps, those who mainly napped in the afternoon, and those with higher levels of anxiety, were more likely to be in the moderately sleepy group.Napping, particularly in the afternoon is associated with poorer cognitive functioning and more daytime sleepiness in CFS. These findings have clinical implications for symptom management strategies.

  15. Daytime naps improve motor imagery learning. (United States)

    Debarnot, Ursula; Castellani, Eleonora; Valenza, Gaetano; Sebastiani, Laura; Guillot, Aymeric


    Sleep is known to contribute to motor memory consolidation. Recent studies have provided evidence that a night of sleep plays a similar functional role following motor imagery (MI), while the simple passage of time does not result in performance gains. Here, we examined the benefits of a daytime nap on motor memory consolidation after MI practice. Participants were trained by MI on an explicitly known sequence of finger movements at 11:00. Half of the participants were then subjected (at 14:00) to either a short nap (10 min of stage 2 sleep) or a long nap (60-90 min, including slow wave sleep and rapid eye movement sleep). We also collected data from both quiet and active rest control groups. All participants remained in the lab until being retested at 16:00. The data revealed that a daytime nap after imagery practice improved motor performance and, therefore, facilitated motor memory consolidation, as compared with spending a similar time interval in the wake state. Interestingly, the results revealed that both short and long naps resulted in similar delayed performance gains. The data might also suggest that the presence of slow wave and rapid eye movement sleep does not provide additional benefits for the sleep-dependent motor skill consolidation following MI practice.

  16. Genetic and phenotypic diversity of Sclerotium rolfsii Sacc. in groundnut fields in central Vietnam

    NARCIS (Netherlands)

    Le, N.C.; Mendes, R.; Kruijt, M.; Raaijmakers, J.


    Groundnut (Arachis hypogaea L.) is an economically important legume crop in Vietnam and many other countries worldwide. Stem and pod rot, caused by the soil-borne fungus Sclerotium rolfsii Sacc., is a major yield limiting factor in groundnut cultivation. To develop sustainable measures to control th

  17. Southern Blight (Sclerotium rolfsii Sacc.) of Cowpea: Genetic Characterization of Two Sources of Resistance (United States)

    Field studies were conducted to determine the inheritance of resistance to southern blight (caused by Sclerotium rolfsii Sacc.) exhibited by the cowpea [Vigna unguiculta (L.) Walp.] cultivars Carolina Cream and Brown Crowder, and to determine if a genetic relationship exists for this resistance betw...

  18. Job demands and resting and napping opportunities for nurses during night shifts: impact on sleepiness and self-evaluated quality of healthcare. (United States)

    Barthe, Béatrice; Tirilly, Ghislaine; Gentil, Catherine; Toupin, Cathy


    The aim of this field study is to describe night shift resting and napping strategies and to examine their beneficial effects on sleepiness and quality of work. The study was carried out with 16 nurses working in an intensive care unit. Data collected during 20 night shifts were related to job demands (systematic observations), to the duration and timing of rests and naps taken by nurses (systematic observations, sleep diaries), to sleepiness (Karolinska Sleepiness Scale), and to quality of work scores (visual analog scale). The results showed that the number of rests and naps depended on the job demands. Resting and napping lowered the levels of sleepiness at the end of the shift. There was no direct relationship between sleepiness and the quality of work score. Discussions about the choice of indicators for the quality of work are necessary. Suggestions for implementing regulations for prescribed napping during night shifts are presented.

  19. NapA and NapB are the Aspergillus nidulans Nap/SET family members and NapB is a nuclear protein specifically interacting with importin alpha. (United States)

    Araújo-Bazán, Lidia; Fernández-Martínez, Javier; Ríos, Vivian Maythe de Los; Etxebeste, Oier; Albar, Juan Pablo; Peñalva, Miguel Angel; Espeso, Eduardo Antonio


    In eukaryotic cells, importin alpha is the major carrier for transport protein cargoes into the nucleus. We characterize here kapA, the single Aspergillus nidulans gene encoding an importin alpha. Using an affinity approach, we identify six potential interactors of KapA(50), a deleted version of KapA lacking the autoinhibitory importin-beta-binding domain. One such interactor is NapB, the A. nidulans orthologue of Saccharomyces cerevisiae Vps75p, a histone chaperone member of the Nap/SET family of proteins that additionally plays a cytosolic role in vacuolar protein sorting. NapB, but not its close relative NapA (the A. nidulans orthologue of yeast Nap1p) interacts directly with KapA(50) in pull down assays, despite the fact that NapB does not contain a classical nuclear localization sequence. NapB is a nuclear protein which exits nuclei at the onset of mitosis when two simultaneous mechanisms might be acting, the partial disassembly of the nuclear pore complexes and as yet unidentified posttranslational modification of NapB. The mitotic cytosolic localization of NapB might facilitate its putative role in the sorting of protein cargoes to the vacuole. In addition, we show that NapB and the mitotic B-type cyclin NimE compete for in vitro binding to KapA.

  20. Antimicrobial activity from endophytic fungi Arthrinium state of Apiospora montagnei Sacc. and Papulaspora immersa

    Directory of Open Access Journals (Sweden)

    Henrique Pereira Ramos


    Full Text Available Papulaspora immersa and Arthrinium state of Apiospora montagnei Sacc. were isolated from the roots of Smallanthus sonchifolius (yacón. The crude extracts from their cultures inhibited the growth of Staphylococcus aureus, Kocuria rhizophila, Pseudomonas aeruginosa and Escherichia coli. The more relevant results were observed in the ethyl acetate extract from P immersa against P aeruginosa (90 µg/mL and ethyl acetate extract from Arthrinium state of A montagnei Sacc. against P aeruginosa (160 µg/mL. The two endophytic fungi isolated from yacón roots as well as their antimicrobial activity detected in the crude extracts cultures were being reported for the first time.Mesmo havendo grandes investimentos, a resistência a fármacos continua sendo um grave problema de saúde pública. Produtos naturais têm prevalecido como a maior fonte de novas drogas e muitos deles são isolados de sistemas simbióticos: microorganismos-plantas. Os fungos endofíticos Papulaspora immersa e Arthrinium state of Apiospora montagnei Sacc. foram isolados de raízes de Smallanthus sonchifolius (yacón. Extratos de culturas destes fungos apresentaram atividade antibacteriana frente Staphylococcus aureus, Kocuria rhizophila, Pseudomonas aeruginosa e Escherichia coli, sendo as mais relevantes observadas nas frações acetato de etila provenientes dos fungos P. immersa e Arthrinium state of Apiospora montagnei Sacc. frente a P. aeruginosa, apresentando CIM de 90µg/mL e 160µg/mL, respectivamente.

  1. A new variety of Pholiota microspora (Berk. Sacc. (Agaricales from Nepal

    Directory of Open Access Journals (Sweden)



    Full Text Available In the fall of late rainy season 2011, a new Pholiota (Fr. P. Kumm. (Agaricales, Strophariaceae was collected in the Quercus forest of Phulchowki (Kathmandu valley along the trial line, on the dead log at an altitude of 2600m. The specimen gathered was quite small. It was brought to laboratory and cultivated in NARC, Pathology laboratory, Lalitpur. The mushroom has been identified as Pholiota microspora (Berk. Sacc. var. himalensis var. nov..

  2. Evaluation of Refractivity Profiles from CHAMP and SAC-C GPS Radio Occultation (United States)

    Poli, Paul; Ao, Chi On; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond


    The GeoForschungsZentrum's Challenging Minisatellite Payload for Geophysical Research and Application (CHAMP, Germany-US) and the Comision Nacional de Actividades Especiales' Satelite de Aplicaciones Cientificas-C (SAC-C, Argentina-US) missions are the first missions to carry a second-generation Blackjack Global Positioning System (GPS) receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS Meteorology experiment (GPS/MET). Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation and Numerical Weather Prediction (NWP). In order to evaluate the refractivity data derived by the Jet Propulsion Laboratory (JPL) from raw radio occultation measurements, we use Data Assimilation Office (DAO) 6-hour forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We show statistics of the differences as well as histograms of the differences.

  3. Promoting alertness with a short nap during a night shift. (United States)

    Sallinen, M; Härmä, M; Akerstedt, T; Rosa, R; Lillqvist, O


    The use of a short (nap in improving alertness during the early morning hours in the first night shift was examined under laboratory conditions. The study contained four experimental, non-consecutive night shifts with a nap of either 50 or 30 min at 01.00 or 04.00 hours. An experimental night shift without a nap served as a control condition. Each experimental shift was followed by daytime sleep. Fourteen experienced male shift workers went through all of the experimental conditions. The results showed that the naps improved the ability to respond to visual signals during the second half of the night shift. Physiological sleepiness was alleviated by the early naps, as measured 50 min after awakening, but not at the end of the shift. Subjective sleepiness was somewhat decreased by the naps. The naps produced sleep inertia which lasted for about 10-15 min. Daytime sleep was somewhat impaired by the 50 min naps. The study shows that a nap shorter than 1 h is able to improve alertness to a certain extent during the first night shift.

  4. Performance Sustainment of Two Man Crews during 87 Hours of Extended Wakefulness with Stimulants and Napping (United States)


    Repeated Test of Sustained Wakefulness (RTSW) .........................................................17  Polysomnography (PSG...N ap 19 Polysomnography (PSG) Nap Effects. A 2-hour nap was provided to determine its effects on restoring performance. During this nap, PSG

  5. The experience of a Power Nap Center in the largest city of Brazil

    Directory of Open Access Journals (Sweden)

    Rogerio Santos-Silva


    Full Text Available We evaluated the frequency of naps and features of nappers who took a nap in a Power Nap Center located in downtown area of São Paulo. Company database was retrospectively analyzed and 4.625 naps were evaluated (January–December 2014. Most naps (57% lasted 30 min. 33% of subjects took a nap more than once a week (73% male. Progressive growth in the number of naps across the months was observed (January=110 to December=505. Results suggest that the society is sleep deprived and taking a nap during the day could be an important strategy to improve quality of life and increase productivity.

  6. Daytime napping associated with increased symptom severity in fibromyalgia syndrome

    NARCIS (Netherlands)

    Theadom, Alice; Cropley, Mark; Kantermann, Thomas


    Background: Previous qualitative research has revealed that people with fibromyalgia use daytime napping as a coping strategy for managing symptoms against clinical advice. Yet there is no evidence to suggest whether daytime napping is beneficial or detrimental for people with fibromyalgia. The purp

  7. The use of caffeine versus prophylactic naps in sustained performance. (United States)

    Bonnet, M H; Gomez, S; Wirth, O; Arand, D L


    Previous studies have shown that performance during sleep loss is improved by prophylactic naps as a function of varying nap length. Based on single-dose caffeine studies, a similar dose-response effect has been hypothesized on performance, alertness and mood during sleep loss. The present study compared the effects of repeated versus single-dose administration of caffeine and varying amounts of sleep taken prior to sleep loss on performance, mood and physiological measures during 2 nights and days of sleep loss. A total of 140 normal, young adult males participated at one of two study sites. Ninety-eight subjects at one site were randomly assigned to one of four nap conditions (0, 2, 4 or 8 hours) and 42 subjects at the second site were assigned to one of four caffeine conditions. After a normal baseline night of sleep and morning baseline tests of performance, mood and nap latency, subjects in the nap groups returned to bed at noon, 1600 hours, 1800 hours or not at all. Bedtimes were varied so that all naps ended at 2000 hours. Subjects in the caffeine groups received either a single 400-mg dose of caffeine at 0130 hours each night or repeated doses of 150 or 300 mg every 6 hours starting at 0130 hours on the 1st night of sleep loss. A placebo control group (no nap and placebo administered every 6 hours on the repeated caffeine schedule) was run at both sites.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. Napping reverses increased pain sensitivity due to sleep restriction.

    Directory of Open Access Journals (Sweden)

    Brice Faraut

    Full Text Available To investigate pain sensitivity after sleep restriction and the restorative effect of napping.A strictly controlled randomized crossover study with continuous polysomnography monitoring was performed.Laboratory-based study.11 healthy male volunteers.Volunteers attended two three-day sessions: "sleep restriction" alone and "sleep restriction and nap". Each session involved a baseline night of normal sleep, a night of sleep deprivation and a night of free recovery sleep. Participants were allowed to sleep only from 02:00 to 04:00 during the sleep deprivation night. During the "sleep restriction and nap" session, volunteers took two 30-minute naps, one in the morning and one in the afternoon.Quantitative sensory testing was performed with heat, cold and pressure, at 10:00 and 16:00, on three areas: the supraspinatus, lower back and thigh. After sleep restriction, quantitative sensory testing revealed differential changes in pain stimuli thresholds, but not in thermal threshold detection: lower back heat pain threshold decreased, pressure pain threshold increased in the supraspinatus area and no change was observed for the thigh. Napping restored responses to heat pain stimuli in the lower back and to pressure stimuli in the supraspinatus area.Sleep restriction induces different types of hypersensitivity to pain stimuli in different body areas, consistent with multilevel mechanisms, these changes being reversed by napping. The napping restorative effect on pain thresholds result principally from effects on pain mechanisms, since it was independent of vigilance status.

  9. The NapF protein of the Escherichia coli periplasmic nitrate reductase system: demonstration of a cytoplasmic location and interaction with the catalytic subunit, NapA. (United States)

    Nilavongse, Arjaree; Brondijk, T Harma C; Overton, Tim W; Richardson, David J; Leach, Emily R; Cole, Jeffrey A


    The periplasmic nitrate reductase of Escherichia coli is important during anaerobic growth in low-nitrate environments. The nap operon encoding this nitrate reductase comprises seven genes including a gene, napF, that encodes a putative cytoplasmic iron-sulphur protein of uncertain subcellular location and function. In this study, N-terminal sequence analysis, cell fractionation coupled with immunoblotting and construction of LacZ and PhoA fusion proteins were used together to establish that NapF is located in the E. coli cytoplasm. A bacterial two-hybrid protein-protein interaction system was used to demonstrate that NapF interacted in the cytoplasm with the terminal oxidoreductase NapA, but that it did not self-associate or interact with other electron-transport components of the Nap system, NapC, NapG or NapH, or with another cytoplasmic component, NapD. NapF, purified as a His(6)-tagged protein, exhibited spectral properties characteristic of an iron-sulphur protein. This protein was able to pull down NapA from soluble extracts of E. coli. A growth-based assay for NapF function in intact cell cultures was developed and applied to assess the effect of mutation of a number of conserved amino acids. It emerged that neither a highly conserved N-terminal double-arginine motif, nor a conserved proline motif, is essential for NapF-dependent growth. The combined data indicate that NapF plays one or more currently unidentified roles in the post-translational modification of NapA prior to the export of folded NapA via the twin-arginine translocation pathway into the periplasm.

  10. CHAOS-a model of the Earth's magnetic field derived from CHAMP, Orsted, and SAC-C magnetic satellite data

    DEFF Research Database (Denmark)

    Olsen, Nils; Luhr, H.; Sabaka, T.J.;


    We have derived a model of the near-Earth magnetic field (up to spherical harmonic degree n= 50 for the static field, and up to n = 18 for the first time derivative) using more than 6.5 yr of high-precision geomagnetic measurements from the three satellites Orsted, CHAMP and SAC-C taken between...

  11. Electron transport to periplasmic nitrate reductase (NapA) of Wolinella succinogenes is independent of a NapC protein. (United States)

    Simon, Jörg; Sänger, Monica; Schuster, Stephan C; Gross, Roland


    The rumen bacterium Wolinella succinogenes grows by respiratory nitrate ammonification with formate as electron donor. Whereas the enzymology and coupling mechanism of nitrite respiration is well known, nitrate reduction to nitrite has not yet been examined. We report here that intact cells and cell fractions catalyse nitrate and chlorate reduction by reduced viologen dyes with high specific activities. A gene cluster encoding components of a putative periplasmic nitrate reductase system (napA, G, H, B, F, L, D) was sequenced. The napA gene was inactivated by inserting a kanamycin resistance gene cassette. The resulting mutant did not grow by nitrate respiration and did not reduce nitrate during growth by fumarate respiration, in contrast to the wild type. An antigen was detected in wild-type cells using an antiserum raised against the periplasmic nitrate reductase (NapA) from Paracoccus pantotrophus. This antigen was absent in the W. succinogenes napA mutant. It is concluded that the periplasmic nitrate reductase NapA is the only respiratory nitrate reductase in W. succinogenes, although a second nitrate-reducing enzyme is apparently induced in the napA mutant. The nap cluster of W. succinogenes lacks a napC gene whose product is thought to function in quinol oxidation and electron transfer to NapA in other bacteria. The W. succinogenes genome encodes two members of the NapC/NirT family, NrfH and FccC. Characterization of corresponding deletion mutants indicates that neither of these two proteins is required for nitrate respiration. A mutant lacking the genes encoding respiratory nitrite reductase (nrfHA) had wild-type properties with respect to nitrate respiration. A model of the electron transport chain of nitrate respiration is proposed in which one or more of the napF, G, H and L gene products mediate electron transport from menaquinol to the periplasmic NapAB complex. Inspection of the W. succinogenes genome sequence suggests that ammonia formation from

  12. Reduction of nitrate in Shewanella oneidensis depends on atypical NAP and NRF systems with NapB as a preferred electron transport protein from CymA to NapA. (United States)

    Gao, Haichun; Yang, Zamin K; Barua, Soumitra; Reed, Samantha B; Romine, Margaret F; Nealson, Kenneth H; Fredrickson, James K; Tiedje, James M; Zhou, Jizhong


    In the genome of Shewanella oneidensis, a napDAGHB gene cluster encoding periplasmic nitrate reductase (NapA) and accessory proteins and an nrfA gene encoding periplasmic nitrite reductase (NrfA) have been identified. These two systems seem to be atypical because the genome lacks genes encoding cytoplasmic membrane electron transport proteins, NapC for NAP and NrfBCD/NrfH for NRF, respectively. Here, we present evidence that reduction of nitrate to ammonium in S. oneidensis is carried out by these atypical systems in a two-step manner. Transcriptional and mutational analyses suggest that CymA, a cytoplasmic membrane electron transport protein, is likely to be the functional replacement of both NapC and NrfH in S. oneidensis. Surprisingly, a strain devoid of napB encoding the small subunit of nitrate reductase exhibited the maximum cell density sooner than the wild type. Further characterization of this strain showed that nitrite was not detected as a free intermediate in its culture and NapB provides a fitness gain for S. oneidensis to compete for nitrate in the environments. On the basis results from mutational analyses of napA, napB, nrfA and napBnrfA in-frame deletion mutants, we propose that NapB is able to favor nitrate reduction by routing electrons to NapA exclusively.

  13. Uut ja vana Tänapäevalt / Krista Kumberg

    Index Scriptorium Estoniae

    Kumberg, Krista


    Kirjastuselt "Tänapäev" 2002. a. ilmunud eesti lastekirjandust: Arder, Ott. Metsapoolne : [luuletused]; Tanner, Oskar, pseud. Kati, päkapikk ja Prominent : [jutustus]; Salu, Kristel. Verdi ja Fred, ehk, Sullerite juhtumised : [jutustus

  14. Practice and nap schedules modulate children's motor learning. (United States)

    Ren, Jie; Guo, Wei; Yan, Jin H; Liu, Guanmin; Jia, Fujun


    Night- or day-time sleep enhances motor skill acquisition. However, prominent issues remained about the circadian (time-of-day) and homeostatic (time since last sleep) effects of sleep on developmental motor learning. Therefore, we examined the effects of nap schedules and nap-test-intervals (NTIs) on the learning of finger tapping sequences on computer keyboards. Children aged 6-7, 8-9, and 10-11 years explicitly acquired the short and long tapping orders that share the same movement strings (4-2-3-1-4, 4-2-3-1-4-2-3-1-4). Following a constant 8- or 10-hr post-learning period in one of the four NTIs (2, 4, 5, 7 hr), children in the morning napping groups, the afternoon napping groups, or the waking group performed the original long sequence in retention test (4-2-3-1-4-2-3-1-4) and the mirrored-order sequence in transfer test (1-3-2-4-1-3-2-4-1). Age and treatment differences in the movement time (MT, ms) and sequence accuracy (SA, %) were compared during skill learning and in retrieval tests. Results suggest that practice or nap affects MT and SA in a greater extent for the younger learners than for the older learners. The circadian effects might not change nap-based skill learning. Importantly, the longer NTIs resulted in superior retention performance than the shorter ones, suggesting that children require a relatively longer post-nap period to form motor memory. Finally, nap-based motor learning was more marked in skill retention than in skill transfer. Brain development may play an important role in motor learning. Our discussion centers on memory consolidation and its relevance for skill acquisition from early to late childhood.

  15. GPS radio occultation with CHAMP and SAC-C: global monitoring of thermal tropopause parameters

    Directory of Open Access Journals (Sweden)

    T. Schmidt


    Full Text Available In this study the global lapse-rate tropopause (LRT pressure, temperature, potential temperature, and sharpness are discussed based on Global Positioning System (GPS radio occultations (RO from the German CHAMP (CHAllenging Minisatellite Payload and the U.S.-Argentinian SAC-C (Satelite de Aplicaciones Cientificas-C satellite missions. Results with respect to seasonal variations are compared with operational radiosonde data and ECMWF (European Centre for Medium-Range Weather Forecast operational analyses. Results on the tropical quasi-biennial oscillation (QBO are updated from an earlier study. CHAMP RO data are available continuously since May 2001 with on average 150 high resolution temperature profiles per day. SAC-C data are available for several periods in 2001 and 2002. In this study temperature data from CHAMP for the period May 2001-December 2004 and SAC-C data from August 2001-October 2001 and March 2002-November 2002 were used, respectively. The bias between GPS RO temperature profiles and radiosonde data was found to be less than 1.5K between 300 and 10hPa with a standard deviation of 2-3K. Between 200-20hPa the bias is even less than 0.5K (2K standard deviation. The mean deviations based on 167699 comparisons between CHAMP/SAC-C and ECMWF LRT parameters are (-2.1±37.1hPa for pressure and (0.1±4.2K for temperature. Comparisons of LRT pressure and temperature between CHAMP and nearby radiosondes (13230 resulted in (5.8±19.8hPa and (-0.1±3.3K, respectively. The comparisons between CHAMP/SAC-C and ECMWF show on average the largest differences in the vicinity of the jet streams with up to 700m in LRT altitude and 3K in LRT temperature, respectively. The CHAMP mission generates the first long-term RO data set. Other satellite missions will follow (GRACE, COSMIC, MetOp, TerraSAR-X, EQUARS generating together some thousand temperature profiles daily.

  16. Isolation and fusion of protoplasts from the phytopathogenic fungus Sclerotium rolfsii (Sacc.

    Directory of Open Access Journals (Sweden)

    Sikandar Hayat


    Full Text Available Sclerotium rolfsii (Sacc. is a serious plant pathogenic fungus and lacks perfect (basidial stage in production. Protoplast fusion technology was employed to reconstruct fusants from this fungus. Two strains designated as A and R were used. Maximum protoplast yields of 3.8x10(5 /g mycelia and 2.8x10(5 /g mycelia were formed in strains A and R respectively. Osmotic stabilizer sucrose 1M gave maximum yield. Lysing enzyme at the rate of 15mg/ml was found best for yield. Fusion of protoplasts from strains A and R was carried out in fusion media containing PEG 4000 30% (w/v with 0.2mM CaCl2. Four fusants F1, F2, F3 and F4 were recovered. Morphological, physiological and pathogenic characters of fusants were compared with parent strains on carrots, beans and tomato.


    Directory of Open Access Journals (Sweden)

    Zhao Chen


    Full Text Available The mechanism of Fusarium tricinctum (Corda Sacc. spore inactivation by chlorine dioxide (ClO2 was investigated. During F. tricinctum spore inactivation by ClO2, protein, DNA, and metal ion leakage, enzyme activity, and cell ultrastructure were examined. Protein and DNA leakages were not detected, while there were metal ion leakages of K+, Ca2+, and Mg2+, which were well-correlated with the inactivation rate. The enzyme activities of glucose-6-phosphate dehydrogenase, citrate synthase, and phosphofructokinase were inhibited and were also well-correlated with the inactivation rate. Electron micrographs showed the ultrastructural modifications of spores and demonstrated that spores were heavily distorted and collapsed from their regular structure. Spore surface damage and disruption in inner components was also severe. The metal ion leakage, the inhibition of enzyme activities, and the damage of spore structure were significant in F. tricinctum spore inactivation by ClO2.

  18. Nap sleep preserves associative but not item memory performance. (United States)

    Studte, Sara; Bridger, Emma; Mecklinger, Axel


    Many studies have shown that sleep improves memory performance, and that even short naps during the day are beneficial. Certain physiological components of sleep such as spindles and slow-wave-sleep are thought to be particularly important for memory consolidation. The aim of this experiment was to reveal the role of naps for hippocampus-dependent associative memory (AM) and hippocampus-independent item memory (IM) alongside their corresponding ERP old/new effects. Participants learnt single words and word-pairs before performing an IM- and an AM-test (baseline). One group was subsequently allowed to nap (∼90min) while the other watched DVDs (control group). Afterwards, both groups performed a final IM- and AM-test for the learned stimuli (posttest). IM performance decreased for both groups, while AM performance decreased for the control group but remained constant for the nap group, consistent with predictions concerning the selective impact of napping on hippocampus-dependent recognition. Putative ERP correlates of familiarity and recollection were observed in the IM posttest, whereas only the later recollection-related effect was present in the AM test. Notably, none of these effects varied with group. Positive correlations were observed between spindle density during slow-wave-sleep and AM posttest performance as well as between spindle density during non-REM sleep and AM baseline performance, showing that successful learning and retrieval both before and after sleep relates to spindle density during nap sleep. Together, these results speak for a selective beneficial impact of naps on hippocampus-dependent memories.

  19. Molecular evolution and species-specific expansion of the NAP members in plants

    Institute of Scientific and Technical Information of China (English)

    Kai Fan,; Hao Shen,; Noreen Bibi,; Feng Li,; Shuna Yuan,; Ming Wang; Xuede Wang


    The NAP (NAC-Like, Activated by AP3/PI) subfamily is one of the important plant-specific transcription factors, and controls many vital biological processes in plants. In the current study, 197 NAP proteins were identified from 31 vascular plants, but no NAP members were found in eight non-vascular plants. Al NAP proteins were phylogenetical y classified into two groups (NAP I and NAP II), and the origin time of the NAP I group might be relatively later than that of the NAP II group. Furthermore, species-specific gene duplications, caused by segmental duplication events, resulted in the expansion of the NAP subfamily after species-divergence. Different groups have different expansion rates, and the NAP group preference was found during the expansion in plants. Moreover, the expansion of NAP proteins may be related to the gain and loss of introns. Besides, functional divergence was limited after the gene duplication. Abscisic acid (ABA) might play an important role in leaf senescence, which is regulated by NAP subfamily. These results could lay an important foundation for expansion and evolutionary analysis of NAP subfamily in plants.

  20. Sonochemical synthesis of zeolite NaP from clinoptilolite. (United States)

    Behin, Jamshid; Kazemian, Hossein; Rohani, Sohrab


    In the present work, natural clinoptilolite was converted to zeolite NaP using ultrasonic energy, in which the transformation time shortened remarkably. The effect of post-synthesis treatment using conventional hydrothermal was also investigated. The synthesized powders were characterized by XRD, TGA/DTA, SEM, and PSD analysis. The results showed that, increasing the sonication time (energy) has no significant effect on the product's morphology. The crystallinity of the synthesized samples increased slightly with increasing sonication time, but their yield remained relatively unchanged. Furthermore, post-synthesis hydrothermal treatment showed very little influence on properties of the final product. Because the ultrasonic irradiation creates acoustic cavitation cracks on the surface structure of clinoptilolite particulates and increases the concentration of soluble alumino-silicate species, which favors the prevailing super-saturation, crystallization and crystal growth of zeolite NaP happen faster. The particles of zeolite NaP synthesized by ultrasonic irradiation consist of small crystallites of uniform size.

  1. Use of NAP gene to manipulate leaf senescence in plants (United States)

    Gan, Susheng; Guo, Yongfeng


    The present invention discloses transgenic plants having an altered level of NAP protein compared to that of a non-transgenic plant, where the transgenic plants display an altered leaf senescence phenotype relative to a non-transgenic plant, as well as mutant plants comprising an inactivated NAP gene, where mutant plants display a delayed leaf senescence phenotype compared to that of a non-mutant plant. The present invention also discloses methods for delaying leaf senescence in a plant, as well as methods of making a mutant plant having a decreased level of NAP protein compared to that of a non-mutant plant, where the mutant plant displays a delayed leaf senescence phenotype relative to a non-mutant plant. Methods for causing precocious leaf senescence or promoting leaf senescence in a plant are also disclosed. Also disclosed are methods of identifying a candidate plant suitable for breeding that displays a delayed leaf senescence and/or enhanced yield phenotype.

  2. A global model of mantle conductivity derived from 5 years of CHAMP, Orsted, and SAC-C magnetic data

    DEFF Research Database (Denmark)

    Kuvshinov, A.; Olsen, Nils


    We present a global 1-D conductivity model which is obtained by analysis of five years ( 2001 - 2005) of simultaneous magnetic data from the three satellites Orsted, CHAMP and SAC-C. After removal of core and crustal fields as predicted by a recent field model we used non-polar scalar and vector...... model which is rather similar to models derived from ground-based data....

  3. Sleep to the beat : A nap favours consolidation of timing

    NARCIS (Netherlands)

    Verweij, Ilse M; Onuki, Yoshiyuki; Van Someren, Eus J W; Van der Werf, Ysbrand D


    Growing evidence suggests that sleep is important for procedural learning, but few studies have investigated the effect of sleep on the temporal aspects of motor skill learning. We assessed the effect of a 90-min day-time nap on learning a motor timing task, using 2 adaptations of a serial intercept

  4. Taking a nap is the new white-knuckle ride. (United States)

    Bates, Jane


    I awoke from my afternoon slumber, stretched like a cat on a warm pillow, slept some more, then opened my eyes and contemplated the sheer joy of an afternoon nap in summer, lulled to sleep by the sun and the sound of bees buzzing and doves cooing….

  5. Delayed benefit of naps on motor learning in preschool children. (United States)

    Desrochers, Phillip C; Kurdziel, Laura B F; Spencer, Rebecca M C


    Sleep benefits memory consolidation across a variety of domains in young adults. However, while declarative memories benefit from sleep in young children, such improvements are not consistently seen for procedural skill learning. Here we examined whether performance improvements on a procedural task, although not immediately observed, are evident after a longer delay when augmented by overnight sleep (24 h after learning). We trained 47 children, aged 33-71 months, on a serial reaction time task and, using a within-subject design, evaluated performance at three time points: immediately after learning, after a daytime nap (nap condition) or equivalent wake opportunity (wake condition), and 24 h after learning. Consistent with previous studies, performance improvements following the nap did not differ from performance improvements following an equivalent interval spent awake. However, significant benefits of the nap were found when performance was assessed 24 h after learning. This research demonstrates that motor skill learning is benefited by sleep, but that this benefit is only evident after an extended period of time.

  6. Effects of some ecological factors on Dothichiza populea Sacc. et Br. growth

    Directory of Open Access Journals (Sweden)

    Pap Predrag L.


    Full Text Available The aim of the present work was to evaluate the mycelial growth and fruiting vigor of Dothichiza populea Sacc. et Br. under various temperatures, pH values, and light regimes. Effect of temperature on the fungus growth was examined by growing isolates in polythermostat at 5°C to 30°C. The best mycelial growth occurred at 20°C, while at 30°C it was inhibited. Fruiting of the fungus was not observed at 5°C, 25°C, and 30°C. However, the best fruiting of the isolates appeared at 20°C. The influence of different pH of the cultivation medium (3,5-10 on the fungus isolates growth was also evaluated. Optimal pH for the fungus growth ranged between 6 and 8, while formation of reproductive organs occurred at all pH values. The influence of two light regimes (light/dark regime and continuous dark on the fungus growth was also studied. Obtained results showed that mycelial growth and fruiting of the fungus were considerably better under the light/dark regime.

  7. First report of Clostridium difficile NAP1/027 in a Mexican hospital.

    Directory of Open Access Journals (Sweden)

    Adrián Camacho-Ortiz

    Full Text Available Clostridium difficile NAP1/ribotype 027 is associated with severe disease and high mortality rates. Our aim was to determine the prevalence of NAP1/ribotype 027 among C. difficile isolates in a tertiary care hospital, and review the main clinical data.We included 106 stool samples from 106 patients. Samples were tested for A&B toxins and were cultured on CCFA agar. The genes tcdA, tcdB, tcdC, cdtA, and cdtB were amplified using PCR in clinical isolates. The tcdA 3'-end deletion analysis, PCR-ribotyping, and pulsed-field gel electrophoresis (PFGE were also performed. Stool samples that were positive for culture were tested by the GeneXpert C. difficile assay. Clinical data were collected.Thirty-six patients tested positive for A&B toxins; and 22 patients had positive culture for C. difficile, 14 of which tested positive for the A&B toxins and all 22 patients tested positive by the GeneXpert C. difficile assay. Risk factors included an average hospital stay of 16.1 days prior to toxin detection, average antibiotic use for 16.2 days, and a median of 3 antibiotics used. The 30-day crude mortality rate was 8.4%. Six of the 22 patients died, and 3 of those deaths were directly attributed to C. difficile infection. The majority of isolates, 90.9% (20/22, carried genes tcdB, tcdA, cdtA, and cdtB; and these strains carried the corresponding downregulator gene tcdC, with an 18-bp deletion. PFGE was performed on 17 isolates, and one main pattern was observed. Analysis of the ribotyping data showed similar results.The above findings represent the clonal spread of C. difficile in our institution, which mainly includes the NAP1/027 strain. This is the first report of C. difficile ribotype NAP1/027 in Mexico.

  8. Teamwork in Acute Care: Perceptions of Essential but Unheard Assistive Personnel and the Counterpoint of Perceptions of Registered Nurses. (United States)

    Bellury, Lanell; Hodges, Helen; Camp, Amanda; Aduddell, Kathie


    Teams of unlicensed personnel and registered nurses have provided hospital-based nursing care for decades. Although ineffective teamwork has been associated with poor patient outcomes, little is known of the perspectives of nursing assistive personnel (NAP). The purpose of this study was to gain insights into the perceptions of NAP and professional registered nurses (RNs) on teamwork in acute care. In a qualitative descriptive approach in a metropolitan hospital in the southeastern United States, 33 NAP participated in audio-recorded focus group sessions, and 18 RNs provided responses to open-ended electronic survey questions. Findings were examined in relation to previously identified coordinating mechanisms of teamwork: shared mental models, closed-loop communication, and mutual trust. None of the mechanisms was strongly represented in these data. In contrast to RNs' mental models, NAP perceptions of teamwork included the centrality of holistic caring to the NAP role, functional teams as NAP-only teams, NAPs and RNs working in parallel spheres rather than together, and team coordination in silos. Closed-loop communication was less common than one-way requests. Mutual trust was desired, but RNs' delegation of tasks conveyed to NAP a lack of value and respect for the NAP role, while RNs perceived a professional obligation to delegate care to ensure quality of care amid changing patient priorities. Further empirical research into NAP practice is needed to enhance understanding of teamwork issues and direct effective interventions to improve work environments and ultimately patient outcomes. © 2016 Wiley Periodicals, Inc.

  9. Dual Roles of Helicobacter pylori NapA in inducing and combating oxidative stress. (United States)

    Wang, Ge; Hong, Yang; Olczak, Adriana; Maier, Susan E; Maier, Robert J


    Neutrophil-activating protein (NapA) has been well documented to play roles in human neutrophil recruitment and in stimulating host cell production of reactive oxygen intermediates (ROI). A separate role for NapA in combating oxidative stress within H. pylori was implied by studies of various H. pylori mutant strains. Here, physiological analysis of a napA strain was the approach used to assess the iron-sequestering and stress resistance roles of NapA, its role in preventing oxidative DNA damage, and its importance to mouse colonization. The napA strain was more sensitive to oxidative stress reagents and to oxygen, and it contained fourfold more intracellular free iron and more damaged DNA than the parent strain. Pure, iron-loaded NapA bound to DNA, but native NapA did not, presumably linking iron levels sensed by NapA to DNA damage protection. Despite its in vitro phenotype of sensitivity to oxidative stress, the napA strain showed normal (like that of the wild type) mouse colonization efficiency in the conventional in vivo assay. By use of a modified mouse inoculation protocol whereby nonviable H. pylori is first inoculated into mice, followed by (live) bacterial strain administration, an in vivo role for NapA in colonization efficiency could be demonstrated. NapA is the critical component responsible for inducing host-mediated ROI production, thus inhibiting colonization by the napA strain. An animal colonization experiment with a mixed-strain infection protocol further demonstrated that the napA strain has significantly decreased ability to survive when competing with the wild type. H. pylori NapA has unique and separate roles in gastric pathogenesis.

  10. Control of Colletotrichum gloeosporioides (penz. Sacc. In yellow passion fruit using Cymbopogon citratus essential oil

    Directory of Open Access Journals (Sweden)

    Nina Duarte Anaruma


    Full Text Available The use of antibiotics in agriculture is limited when compared to their applications in human and veterinary medicine. On the other hand, the use of antimicrobials in agriculture contributes to the drug resistance of human pathogens and has stimulated the search for new antibiotics from natural products. Essential oils have been shown to exert several biological activities including antibacterial and antifungal actions. The aim of this study was to determine the activity of 28 essential oils from medicinal plants cultivated at CPMA (Medicinal and Aromatic Plants Collection, CPQBA/UNICAMP, against Colletotrichum gloeosporioides (Penz. Sacc., the anthracnose agent in yellow passion fruit (Passiflora edulis Sims f. flavicarpa Deg, as well as evaluating their effect in the control of post-harvest decay. The oils were obtained by water-distillation using a Clevenger-type system and their minimal inhibitory concentrations (MIC determined by the micro-dilution method. According to the results, 15 of the 28 essential oils presented activity against Colletotrichum gloeosporioides, and the following four oils presented MIC values between 0.25 and 0.3 mg/mL: Coriandrum sativum, Cymbopogon citratus, Cymbopogon flexuosus and Lippia alba. The evaluation of Cymbopogon citratus essential oil in the control of post-harvest decay in yellow passion fruit showed that the disease index of the samples treated with the essential oil did not differ (P < 0.05 from that of the samples treated with fungicide. The present study shows the potential of Cymbopogon citratus essential oil in the control of the anthracnose agent in yellow passion fruit.

  11. Control of Colletotrichum gloeosporioides (penz.) Sacc. In yellow passion fruit using Cymbopogon citratus essential oil. (United States)

    Anaruma, Nina Duarte; Schmidt, Flávio Luís; Duarte, Marta Cristina Teixeira; Figueira, Glyn Mara; Delarmelina, Camila; Benato, Liane Aparecida; Sartoratto, Adilson


    The use of antibiotics in agriculture is limited when compared to their applications in human and veterinary medicine. On the other hand, the use of antimicrobials in agriculture contributes to the drug resistance of human pathogens and has stimulated the search for new antibiotics from natural products. Essential oils have been shown to exert several biological activities including antibacterial and antifungal actions. The aim of this study was to determine the activity of 28 essential oils from medicinal plants cultivated at CPMA (Medicinal and Aromatic Plants Collection), CPQBA/UNICAMP, against Colletotrichum gloeosporioides (Penz.) Sacc., the anthracnose agent in yellow passion fruit (Passiflora edulis Sims f. flavicarpa Deg), as well as evaluating their effect in the control of post-harvest decay. The oils were obtained by water-distillation using a Clevenger-type system and their minimal inhibitory concentrations (MIC) determined by the micro-dilution method. According to the results, 15 of the 28 essential oils presented activity against Colletotrichum gloeosporioides, and the following four oils presented MIC values between 0.25 and 0.3 mg/mL: Coriandrum sativum, Cymbopogon citratus, Cymbopogon flexuosus and Lippia alba. The evaluation of Cymbopogon citratus essential oil in the control of post-harvest decay in yellow passion fruit showed that the disease index of the samples treated with the essential oil did not differ (P ≤ 0.05) from that of the samples treated with fungicide. The present study shows the potential of Cymbopogon citratus essential oil in the control of the anthracnose agent in yellow passion fruit.

  12. Susceptibilidad a Fusarium verticillioides (Sacc.) Nirenberg en la población de maíz MPB-FCA 8561


    Peiretti-Uzal, Daniel Antonio; Nazar-Lovera, María Cristina; Biasutti-Valenzano, Carlos Alberto; Giorda-Lerda, Laura María


    Susceptibilidad a Fusarium verticillioides (Sacc.) Nirenberg en la población de maíz MPB-FCA 856. Se caracterizó la variabilidad genética de caracteres de la mazorca y susceptibilidad al desarrollo de la podredumbre de la mazorca (Fusarium verticillioides (Sacc.) Nirenberg) en la población de maíz MPB-FCA 856. En Córdoba, Argentina, durante la estación primavera verano 2004/2005, 120 medio hermanos, un híbrido resistente (HR) y otro susceptible (HS), fueron evaluados en un ensayo en bloques c...

  13. Susceptibilidad a fusarium verticillioides (sacc.) nirenberg en la población de maíz mpb-fca 856


    Daniel Antonio Peiretti-Uzal; Mar\\u00EDa Cristina Nazar-Lovera; Carlos Alberto Biasutti-Valenzano; Laura Mar\\u00EDa Giorda-Lerda


    Susceptibilidad a Fusarium verticillioides (Sacc.) Nirenberg en la población de maíz MPB-FCA 856. Se caracterizó la variabilidad genética de caracteres de la mazorca y susceptibilidad al desarrollo de la podredumbre de la mazorca (Fusarium verticillioides (Sacc.) Nirenberg) en la población de maíz MPB-FCA 856. En Córdoba, Argentina, durante la estación primavera verano 2004/2005, 120 medio hermanos, un híbrido resistente (HR) y otro susceptible (HS), fueron evaluados e...

  14. Napping Reverses Increased Pain Sensitivity Due to Sleep Restriction


    Brice Faraut; Damien Léger; Terkia Medkour; Alexandre Dubois; Virginie Bayon; Mounir Chennaoui; Serge Perrot


    Study Objective To investigate pain sensitivity after sleep restriction and the restorative effect of napping. Design A strictly controlled randomized crossover study with continuous polysomnography monitoring was performed. Setting Laboratory-based study. Participants 11 healthy male volunteers. Interventions Volunteers attended two three-day sessions: “sleep restriction” alone and “sleep restriction and nap”. Each session involved a baseline night of normal sleep, a night of sleep deprivati...

  15. Low altitude energetic electron lifetimes after enhanced magnetic activity as deduced from SAC-C and DEMETER data

    Directory of Open Access Journals (Sweden)

    S. Benck


    Full Text Available When flux enhancements of energetic electrons are produced as a consequence of geomagnetic storm occurrence, they tend to vanish gradually when the magnetic activity calms down and the fluxes decay to quiet-time levels. We use SAC-C and DEMETER low altitude observations to estimate the energetic electron lifetimes (E=0.16–1.4 MeV, L=1.6–5, B=0.22–0.46 G and compare the decay rates to those observed at high altitude. While crossing the radiation belts at high latitude, the SAC-C and DEMETER instruments sample particles with small equatorial pitch angles (αeq<18° for L>2.5 whereas the comparison is done with other satellite data measured mainly in the equatorial plane (for αeq>75°. While in the inner belt and in the slot region no significant lifetime differences are observed from the data sets with different αeq, in the outer belt, for the least energetic electrons (<500 keV, the lifetimes are up to ~3 times larger for the electrons with the equatorial pitch-angle close to the loss cone than for those mirroring near the equator. The difference decreases with increasing energy and vanishes for energies of about 1 MeV.

  16. Influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma (SACC) - 83 and SACC-LM cells%特异性抑制剂对腺样囊性癌细胞中蛋白激酶B表达的影响

    Institute of Scientific and Technical Information of China (English)

    杨鸣良; 沈磊; 孙长伏



  17. The ADNP derived peptide, NAP modulates the tubulin pool: implication for neurotrophic and neuroprotective activities.

    Directory of Open Access Journals (Sweden)

    Saar Oz

    Full Text Available Microtubules (MTs, key cytoskeletal elements in living cells, are critical for axonal transport, synaptic transmission, and maintenance of neuronal morphology. NAP (NAPVSIPQ is a neuroprotective peptide derived from the essential activity-dependent neuroprotective protein (ADNP. In Alzheimer's disease models, NAP protects against tauopathy and cognitive decline. Here, we show that NAP treatment significantly affected the alpha tubulin tyrosination cycle in the neuronal differentiation model, rat pheochromocytoma (PC12 and in rat cortical astrocytes. The effect on tubulin tyrosination/detyrosination was coupled to increased MT network area (measured in PC12 cells, which is directly related to neurite outgrowth. Tubulin beta3, a marker for neurite outgrowth/neuronal differentiation significantly increased after NAP treatment. In rat cortical neurons, NAP doubled the area of dynamic MT invasion (Tyr-tubulin into the neuronal growth cone periphery. NAP was previously shown to protect against zinc-induced MT/neurite destruction and neuronal death, here, in PC12 cells, NAP treatment reversed zinc-decreased tau-tubulin-MT interaction and protected against death. NAP effects on the MT pool, coupled with increased tau engagement on compromised MTs imply an important role in neuronal plasticity, protecting against free tau accumulation leading to tauopathy. With tauopathy representing a major pathological hallmark in Alzheimer's disease and related disorders, the current findings provide a mechanistic basis for further development. NAP (davunetide is in phase 2/3 clinical trial in progressive supranuclear palsy, a disease presenting MT deficiency and tau pathology.

  18. Dual Roles of Helicobacter pylori NapA in Inducing and Combating Oxidative Stress▿


    Wang, Ge; Hong, Yang; Olczak, Adriana; Maier, Susan E.; Maier, Robert J.


    Neutrophil-activating protein (NapA) has been well documented to play roles in human neutrophil recruitment and in stimulating host cell production of reactive oxygen intermediates (ROI). A separate role for NapA in combating oxidative stress within H. pylori was implied by studies of various H. pylori mutant strains. Here, physiological analysis of a napA strain was the approach used to assess the iron-sequestering and stress resistance roles of NapA, its role in preventing oxidative DNA dam...

  19. CM5, a pre-Swarm comprehensive geomagnetic field model derived from over 12 yr of CHAMP, Ørsted, SAC-C and observatory data

    DEFF Research Database (Denmark)

    Sabaka, Terence J.; Olsen, Nils; Tyler, Robert H.;


    A comprehensive magnetic field model named CM5 has been derived from CHAMP, Orsted and SAC-C satellite and observatory hourly-means data from 2000 August to 2013 January using the Swarm Level-2 Comprehensive Inversion (CI) algorithm. Swarm is a recently launched constellation of three satellites ...

  20. Proposal to conserve the name Phomopsis citri H.S. Fawc. (Diaporthe citri), with a conserved type, against Phomopsis citri (Sacc.) Traverso & Spessa (Ascomycota, Diaporthales, Diaporthaceae) (United States)

    The name Diaporthe citri applies to a fungus that causes a disease on Citrus known as melanose or stem end rot of mature fruit after harvest and occurs widely in North America and Asia. Initially described as the illegitimate Phomopsis citri H.S. Fawc. 1912, non P. citri (Sacc.) Traverso & Spessa 19...

  1. Hiiumaa kiviajast tänapäevani / Endel Saar

    Index Scriptorium Estoniae

    Saar, Endel


    Järg Feb/10;17 Mar/3;10;17;24;31 Apr/7;21;28 May/5;26 Jun/2;9;16;30 Jul/7;14;21;28 Aug/4;11;18;25 Sep/8 ;15;22;29 Oct/6;13;20;27 Nov/3;10;24 Dec/1;8;15;22;29. Biosfääri Kaitseala Keskuse poolt koostatud atlas "Administratiivsete muutuste ülevaatekaart", kus antakse ülevaade Hiiumaa arenguloost kiviajast tänapäevani

  2. Nap-titration : An effective alternative for continuous positive airway pressure titration

    NARCIS (Netherlands)

    Hoekema, A; Stegenga, B; Meinesz, AF; van der Hoeven, JH; Wijkstra, PJ


    When treating Obstructive Steep Apnea-Hypopnea Syndrome (OSAHS) several alternatives for standard (manual) continuous positive airway pressure (CPAP) titration are feasible. A practical alternative is titration without polysomnography during an afternoon nap (Nap-titration). The aim of the present s

  3. Naps in school can enhance the duration of declarative memories learned by adolescents

    Directory of Open Access Journals (Sweden)

    Nathalia eLemos


    Full Text Available Sleep helps the consolidation of declarative memories in the laboratory, but the pro-mnemonic effect of daytime naps in schools is yet to be fully characterized. While a few studies indicate that sleep can indeed benefit school learning, it remains unclear how best to use it. Here we set out to evaluate the influence of daytime naps on the duration of declarative memories learned in school by students of 10-15 years old. A total of 584 students from 6th grade were investigated. Students within a regular classroom were exposed to a 15-minute lecture on new declarative contents, absent from the standard curriculum for this age group. The students were then randomly sorted into nap and non-nap groups. Students in the nap group were conducted to a quiet room with mats, received sleep masks and were invited to sleep. At the same time, students in the non-nap group attended regular school classes given by their usual teacher (Experiment I, or English classes given by another experimenter (Experiment II. In Experiment I (n=371, students were pre-tested on lecture-related contents before the lecture, were invited to nap for up to 2 hours, and after 1, 2 or 5 days received surprise tests with similar content but different wording and question order. In Experiment II (n=213, students were invited to nap for up to 50 minutes (duration of a regular class; surprise tests were applied immediately after the lecture, and repeated after 5, 30 or 110 days. Experiment I showed a significant ~10% gain in test scores for both nap and non-nap groups 1 day after learning, in comparison with pre-test scores. This gain was sustained in the nap group after 2 and 5 days, but in the non-nap group it decayed completely after 5 days. In Experiment II, the nap group showed significantly higher scores than the non-nap group at all times tested, thus precluding specific conclusions. The results suggest that sleep can be used to enhance the duration of memory contents learned in

  4. Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer. (United States)

    Liu, Jingjing; Liu, Huimin; Zhang, Tingting; Ren, Xiyun; Nadolny, Christina; Dong, Xiaoqun; Huang, Lina; Yuan, Kexin; Tian, Wenjing; Jia, Yunhe


    Helicobacter pylori (H. pylori) infection is strongly associated with gastric cancer. However, only a minority of infected individuals ever develop gastric cancer. This risk stratification may be in part due to differences among strains. The relationship between neutrophil-activating protein (NapA) and gastric cancer is unclear. The purpose of this study is to evaluate the significance of NapA as a biomarker in gastric cancer. We used enzyme linked immunosorbent assay (ELISA) to determine the status of H. pylori infection. Indirect ELISA method was used for detection of NapA antibody titer in the serum of H. pylori infected individuals. Unconditional logistic regressions were adopted to analyze the variables and determine the association of NapA and gastric cancer. The results of study indicated serum H. pylori NapA antibody level were associated with a reduced risk for development of gastric cancer. It may be used in conjugation with other indicators for gastric cancer detection.

  5. Duration of sleep inertia after napping during simulated night work and in extended operations. (United States)

    Signal, Tracey Leigh; van den Berg, Margo J; Mulrine, Hannah M; Gander, Philippa H


    Due to the mixed findings of previous studies, it is still difficult to provide guidance on how to best manage sleep inertia after waking from naps in operational settings. One of the few factors that can be manipulated is the duration of the nap opportunity. The aim of the present study was to investigate the magnitude and time course of sleep inertia after waking from short (20-, 40- or 60-min) naps during simulated night work and extended operations. In addition, the effect of sleep stage on awakening and duration of slow wave sleep (SWS) on sleep inertia was assessed. Two within-subject protocols were conducted in a controlled laboratory setting. Twenty-four healthy young men (Protocol 1: n = 12, mean age = 25.1 yrs; Protocol 2: n = 12, mean age = 23.2 yrs) were provided with nap opportunities of 20-, 40-, and 60-min (and a control condition of no nap) ending at 02:00 h after ∼20 h of wakefulness (Protocol 1 [P1]: simulated night work) or ending at 12:00 h after ∼30 h of wakefulness (Protocol 2 [P2]: simulated extended operations). A 6-min test battery, including the Karolinska Sleepiness Scale (KSS) and the 4-min 2-Back Working Memory Task (WMT), was repeated every 15 min the first hour after waking. Nap sleep was recorded polysomnographically, and in all nap opportunities sleep onset latency was short and sleep efficiency high. Mixed-model analyses of variance (ANOVA) for repeated measures were calculated and included the factors time (time post-nap), nap opportunity (duration of nap provided), order (order in which the four protocols were completed), and the interaction of these terms. Results showed no test x nap opportunity effect (i.e., no effect of sleep inertia) on KSS. However, WMT performance was impaired (slower reaction time, fewer correct responses, and increased omissions) on the first test post-nap, primarily after a 40- or 60-min nap. In P2 only, performance improvement was evident 45 min post-awakening for naps of 40 min or more. In ANOVAs

  6. Coordinated Action of Nap1 and RSC in Disassembly of Tandem Nucleosomes. (United States)

    Prasad, Rashmi; D'Arcy, Sheena; Hada, Arjan; Luger, Karolin; Bartholomew, Blaine


    The SWI/SNF and RSC family of ATP-dependent chromatin remodelers disassembles nucleosomes by moving nucleosomes into the vicinity of adjoining nucleosomes. We found that the histone chaperone Nap1 efficiently promotes disassembly of adjacent nucleosomes with which RSC collides and not the disassembly of nucleosomes mobilized by RSC. Nap1 is specific to RSC, as it does not target SWI/SNF, its paralog in Saccharomyces cerevisiae Extensive mutational analysis of Nap1 has revealed that Nap1 affinity for histones H2A-H2B and H3-H4 and its ability to displace histones from DNA are required for Nap1 to enhance RSC-mediated disassembly. Other histone chaperones, such as Vps75, that also bind histones are not able to enhance RSC-mediated disassembly. Our study suggests a mechanism by which Nap1 is recruited to actively transcribed regions and assists in the passage of the transcription complex through chromatin, and it provides a novel mechanism for the coordinated action of RSC and Nap1.

  7. Resolution of two native monomeric 90kDa nitrate reductase active proteins from Shewanella gelidimarina and the sequence of two napA genes. (United States)

    Simpson, Philippa J L; McKinzie, Audra A; Codd, Rachel


    The reduction of nitrate to nitrite in the bacterial periplasm occurs in the 90kDa NapA subunit of the periplasmic nitrate reductase (NAP) system. Most Shewanella genomes contain two nap operons: napEDABC and napDAGHB, which is an unusual feature of this genus. Two native, monomeric, 90kDa nitrate reductase active proteins were resolved by hydrophobic interaction chromatography from aerobic cultures of Shewanella gelidimarina replete with reduced nitrogen compounds. The 90kDa protein obtained in higher yield was characterized as NapA by electronic absorption and electron paramagnetic resonance spectroscopies and was identified by LC/MS/MS and MALDI-TOF/TOF MS as NapA from the napEDABC-type operon. The other 90kDa protein, which was unstable and produced in low yields, was posited as NapA from the napDAGHB-type operon. Two napA genes have been sequenced from the napEDABC-type and napDAGHB-type operons of S. gelidimarina. Native NAP from S. putrefaciens was resolved as one NapA monomer and one NapAB heterodimer. Two amino acid substitutions in NapA correlated with the isolation of NAP as a NapA monomer or a NapAB heterodimer. The resolution of native, redox-active NapA isoforms in Shewanella provides new insight into the respiratory versatility of this genus, which has implications in bioremediation and the assembly of microbial fuel cells.

  8. Reactive oxygen species and autophagy associated apoptosis and limitation of clonogenic survival induced by zoledronic acid in salivary adenoid cystic carcinoma cell line SACC-83.

    Directory of Open Access Journals (Sweden)

    Xi-Yuan Ge

    Full Text Available Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites. Zoledronic acid, a third generation bisphosphonate, has been used for tumor-induced osteolysis due to bone metastasis and has direct antitumor activity in several human neoplasms. Here, we observed that zoledronic acid inhibited salivary adenoid cystic carcinoma cell line SACC-83 xenograft tumor growth in nude mice. In vitro, zoledronic acid induced apoptosis and reduced clonogenic survival in SACC-83. Flow cytometry and western blotting indicated that the cell cycle was arrested at G0/G1. Zoledronic acid treatment upregulated reactive oxygen species as well as the autophagy marker protein LC-3B. Reactive oxygen species scavenger N-acetylcysteine and autophagy antagonist 3-methyladenine decreased zoledronic acid-induced apoptosis and increased clonogenic survival. Silencing of the autophagy related gene Beclin-1 also decreased zoledronic acid-induced apoptosis and inhibition of clonogenic formation. In addition, isobolographic analysis revealed synergistic effects on apoptosis when zoledronic acid and paclitaxel/cisplatin were combined. Taken together, our results suggest that zoledronic acid induced apoptosis and reduced clonogenic survival via upregulation of reactive oxygen species and autophagy in the SACC-83 cell line. Thus, zoledronic acid should be considered a promising drug for the treatment of salivary adenoid cystic carcinoma.

  9. Relational memory: a daytime nap facilitates the abstraction of general concepts.

    Directory of Open Access Journals (Sweden)

    Hiuyan Lau

    Full Text Available It is increasingly evident that sleep strengthens memory. However, it is not clear whether sleep promotes relational memory, resultant of the integration of disparate memory traces into memory networks linked by commonalities. The present study investigates the effect of a daytime nap, immediately after learning or after a delay, on a relational memory task that requires abstraction of general concept from separately learned items. Specifically, participants learned English meanings of Chinese characters with overlapping semantic components called radicals. They were later tested on new characters sharing the same radicals and on explicitly stating the general concepts represented by the radicals. Regardless of whether the nap occurred immediately after learning or after a delay, the nap participants performed better on both tasks. The results suggest that sleep--even as brief as a nap--facilitates the reorganization of discrete memory traces into flexible relational memory networks.

  10. [Effect of daytime nap on consolidation of declarative memory in humans]. (United States)

    Ukraintseva, Iu V; Dorokhov, V B


    We studied effects of a daytime nap (1 hour) with including only NREM sleep on performance of declarative memory task (60 semantically unrelated word pairs) and general functional state. During training, procedure of learning of 30 word pairs was presented once, and that of the other 30 pairs was repeated twice. Strength of the task acquisition was tested. Subjects participated in two experiments: basic and control one. After learning participants either took a nap (basic experiment) or kept awake looking movies (control experiment). In 4.5 hours after the training session all the subjects were retested. As compared to the subjects who stayed awake during the training-retesting interval, subjects who had a NREM nap demonstrated enhanced performance. Concerning the strength of task acquisition, sleep-dependent performance was observed only for the word pairs learned once. Naps did not affect the functional state assessed by the reaction time dynamics and psychological testing.

  11. Spread of epidemic Clostridium difficile NAP1/027 in Latin America: case reports in Panama. (United States)

    López-Ureña, Diana; Quesada-Gómez, Carlos; Miranda, Erick; Fonseca, Mercedes; Rodríguez-Cavallini, Evelyn


    The rate and severity of Clostridium difficile infection (CDI) have been linked to the emergence and spread of the hypervirulent toxigenic strain NAP1/027. This strain has been responsible for large outbreaks in healthcare facilities in North America and Europe and most recently in Latin America. This is the first report of the NAP1 strain in Panama. It suggests that the spread of C. difficile NAP1 throughout Latin America could be a possibility as evidenced in the following case reports. Five isolates typed as NAP1 had tcdA, tcdB, binary toxin gene cdtB and tcdC deletion. All isolates were resistant to clindamycin, fluoroquinolones and rifampicin. Under this scenario, surveillance programmes for CDI should be implemented in public health facilities in Latin America and diagnosis of CDI should be considered, especially in patients with predisposing factors.

  12. Vanaaegse fototehnikaga katsetamine loob silla mineviku ja tänapäeva vahel / Tanel Verk

    Index Scriptorium Estoniae

    Verk, Tanel


    Fototehnika arengust, vanaaegse fototehnika kasutamisest tänapäeval. Eesti Suureformaadilise Fotograafia Ühenduse fotonäitus "Koosolek" Fotomuuseumi galeriis "Lee" 22. novembrist 2012 kuni 14. jaanuarini 2013

  13. Insomnia Symptoms, Daytime Naps And Physical Leisure Activities In The Elderly: FIBRA Study Campinas

    Directory of Open Access Journals (Sweden)

    Natália Tonon Monteiro


    Full Text Available The practice of physical activities contributes to reducing the risk of chronic diseases and improves sleep patterns in the elderly. This research aimed to investigate the association between insomnia symptoms and daytime nap and the participation in physical leisure activities in elderly community residents. Data from the Studies Network of the Fragility in Brazilian Elderly (Campinas site, were used. Information from 689 elderly was analyzed, regarding sociodemographic characterization, physical leisure activity, occurrence of daytime napping and its duration, symptoms of insomnia and use of sleep medication. A significant association was found between the practice of walking and the daytime nap of short duration. Studies indicate that a short nap can benefit the quality of sleep and health of the elderly. Therefore, promoting the practice of walking can be a nursing intervention that favors the sleep patterns of the elderly.

  14. [Insomnia symptoms, daytime naps and physical leisure activities in the elderly: FIBRA Study Campinas]. (United States)

    Monteiro, Natália Tonon; Neri, Anita Liberalesso; Coelim, Maria Filomena


    The practice of physical activities contributes to reducing the risk of chronic diseases and improves sleep patterns in the elderly. This research aimed to investigate the association between insomnia symptoms and daytime nap and the participation in physical leisure activities in elderly community residents. Data from the Studies Network of the Fragility in Brazilian Elderly (Campinas site), were used. Information from 689 elderly was analyzed, regarding sociodemographic characterization, physical leisure activity, occurrence of daytime napping and its duration, symptoms of insomnia and use of sleep medication. A significant association was found between the practice of walking and the daytime nap of short duration. Studies indicate that a short nap can benefit the quality of sleep and health of the elderly. Therefore, promoting the practice of walking can be a nursing intervention that favors the sleep patterns of the elderly.

  15. eNAP-2, a novel cysteine-rich bactericidal peptide from equine leukocytes.


    Couto, M A; Harwig, S S; Cullor, J S; Hughes, J. P.; Lehrer, R I


    We purified a novel cysteine-rich antibiotic peptide, eNAP-2 (M(r), approximately 6,500), from acid extracts of equine neutrophils by sequential gel filtration and reversed-phase high-performance liquid chromatography and determined its partial N-terminal amino acid sequence. Although its cysteine motif distinguished eNAP-2 from all other currently known endogenous antibiotic peptides, including defensins and granulins, it showed substantial sequence similarity to WDNM1, a putative member of ...

  16. Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Samuel J Bolitho

    Full Text Available INTRODUCTION: Sleep-wake disturbances and concomitant cognitive dysfunction in Parkinson's disease (PD contribute significantly to morbidity in patients and their carers. Subjectively reported daytime sleep disturbance is observed in over half of all patients with PD and has been linked to executive cognitive dysfunction. The current study used daytime actigraphy, a novel objective measure of napping and related this to neuropsychological performance in a sample of PD patients and healthy, age and gender-matched controls. Furthermore this study aimed to identify patients with PD who may benefit from pharmacologic and behavioural intervention to improve these symptoms. METHODS: Eighty-five PD patients and 21 healthy, age-matched controls completed 14 days of wrist actigraphy within two weeks of neuropsychological testing. Objective napping measures were derived from actigraphy using a standardised protocol and subjective daytime sleepiness was recorded by the previously validated Epworth Sleepiness Scale. RESULTS: Patients with PD had a 225% increase in the mean nap time per day (minutes as recorded by actigraphy compared to age matched controls (39.2 ± 35.2 vs. 11.5 ± 11.0 minutes respectively, p < 0.001. Significantly, differences in napping duration between patients, as recorded by actigraphy were not distinguished by their ratings on the subjective measurement of excessive daytime sleepiness. Finally, those patients with excessive daytime napping showed greater cognitive deficits in the domains of attention, semantic verbal fluency and processing speed. CONCLUSION: This study confirms increased levels of napping in PD, a finding that is concordant with subjective reports. However, subjective self-report measures of excessive daytime sleepiness do not robustly identify excessive napping in PD. Fronto-subcortical cognitive dysfunction was observed in those patients who napped excessively. Furthermore, this study suggests that daytime

  17. napäevased liikursuurtükid / Anna Kern

    Index Scriptorium Estoniae

    Kern, Anna


    Riigikaitse arengukavas (a. 2013-2022) on ette nähtud võimalused 1. jalaväebrigaadile hankida tänapäevased liikursuurtükid. Ülevaade liikursuurtükkide loomisest, kasutamisest sõdades ja tänapäevase liikursuurtüki iseloomustus. Näiteid erinevtest liikursuurtükkidest: Archer (Rootsi), Panzerhaubitze 2000 (Saksamaa), Caesar (Prantsusmaa), M777 (USA). Lisatud tabel tehniliste andmetega

  18. Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer


    Jingjing Liu; Huimin Liu; Tingting Zhang; Xiyun Ren; Christina Nadolny; Xiaoqun Dong; Lina Huang; Kexin Yuan; Wenjing Tian; Yunhe Jia


    Helicobacter pylori (H. pylori) infection is strongly associated with gastric cancer. However, only a minority of infected individuals ever develop gastric cancer. This risk stratification may be in part due to differences among strains. The relationship between neutrophil-activating protein (NapA) and gastric cancer is unclear. The purpose of this study is to evaluate the significance of NapA as a biomarker in gastric cancer. We used enzyme linked immunosorbent assay (ELISA) to determine the...

  19. Neutrophil-activating protein (HP-NAP) versus ferritin (Pfr): comparison of synthesis in Helicobacter pylori. (United States)

    Dundon, W G; Polenghi, A; Del Guidice, G; Rappuoli, R; Montecucco, C


    We recently reported that the neutrophil-activating protein (HP-NAP) of Helicobacter pylori is capable of binding iron in vitro. To more fully understand the relationship between iron and HP-NAP the synthesis of HP-NAP was compared to that of Pfr, another iron-binding protein of H. pylori. Synthesis of HP-NAP and Pfr in growing cultures of H. pylori was analysed under iron depletion and iron, copper, nickel and zinc overload. The synthesis of HP-NAP and Pfr in H. pylori was also analysed under conditions of varying pH and oxidative stress. In addition, recombinant HP-NAP and Pfr were produced in Escherichia coli to assess the contribution of the two proteins to increased survival of E. coli under heavy metal overload. Our data reveal that both HP-NAP and Pfr accumulate in the stationary phase of growth. HP-NAP synthesis is not regulated by iron depletion or overload or by the presence of copper, nickel or zinc in liquid medium and it does not confer resistance to these metals when produced in E. coli. Except for an increase in the synthesis of Pfr at pH 5.7 neither the pH or oxidative stress conditions investigated had an affect on the synthesis of either protein. An increase in Pfr synthesis was observed under iron overload and a decrease was observed under conditions of copper, nickel and zinc overload confirming previous reports. Recombinant Pfr, as well as conferring resistance to iron and copper as previously reported, also conferred resistance to zinc overload when produced in E. coli.

  20. [association Between Insomnia Symptoms, Daytime Napping, And Falls In Community-dwelling Elderly].


    Pereira,Alexandre Alves; Ceolim, Maria Filomena; Neri,Anita Liberalesso


    This study focused on associations between insomnia symptoms, daytime napping, and falls in community-dwelling elderly, using a population-based cross-sectional design and probability sample with 689 community-dwelling elders. The protocol consisted of self-reported and physical performance variables. The study used univariate and multivariate logistic regression analysis with statistical significance set at p < 0.05. Prevalence rates for insomnia symptoms and daytime napping were 49.9% (n = ...

  1. Inibição do crescimento micelial de Cercospora calendulae Sacc. por extratos de plantas medicinais

    Directory of Open Access Journals (Sweden)

    J.M. Nascimento


    Full Text Available O uso de extratos e óleos essenciais de plantas medicinais tem sido amplamente estudado no controle de doenças de plantas. O objetivo da realização do presente trabalho foi avaliar o efeito de extratos de Ruta graveolens L., Mentha x villosa, Calendula officinalis L., Momordica charantia L., Symphytum officinale L., Ageratum conyzoides L. e Ricinus comunis L., nas concentrações de 0, 250, 500, 1000, 2000, 5000 e 10000 mg L-1, sobre a inibição do crescimento micelial de Cercospora calendulae Sacc. in vitro. Os extratos foram obtidos por infusão. O experimento foi desenvolvido no Laboratório de Fitopatologia da FCA/UFGD, estado de Mato Grosso do Sul, em delineamento inteiramente casualizado, esquema fatorial 7 extratos x 7 concentrações, com seis repetições. Foi detectado efeito dos extratos e suas concentrações sobre o crescimento do fungo, sendo a interação significativa. Os extratos de calêndula, arruda, hortelã e melão de São Caetano, nas maiores concentrações resultaram em maiores porcentagens de inibição, próximas de 100%, 30%, 35% e 40%, respectivamente, a 10000 mg L-1.

  2. Antifungal activity and inhibition of fumonisin production by Rosmarinus officinalis L. essential oil in Fusarium verticillioides (Sacc.) Nirenberg. (United States)

    da Silva Bomfim, Natalia; Nakassugi, Lydiana Polis; Faggion Pinheiro Oliveira, Jessica; Kohiyama, Cassia Yumie; Mossini, Simone Aparecida Galerani; Grespan, Renata; Nerilo, Samuel Botião; Mallmann, Carlos Augusto; Alves Abreu Filho, Benicio; Machinski, Miguel


    The chemical composition of Rosmarinus officinalis L. essential oil (REO) was analysed by gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy. The main compounds of the REO were 1.8 cineole (52.2%), camphor (15.2%) and α-pinene (12.4%). The mycelial growth of Fusarium verticillioides (Sacc.) Nirenberg was reduced significantly by 150 μg/mL of REO. Significant microscopic morphological changes were visualised, such as the rupture of the cell wall and the leakage of cytoplasm at 300 μg/mL of REO. At lower concentrations of REO, the effects on the production of ergosterol and the biomass of mycelium varied, as did the effects on the production of fumonisins, but at ≥300 μg/mL of REO, these processes were significantly inhibited, showing the effectiveness of the REO as an antifungal agent. The results suggested that the REO acts against F. verticillioides by disrupting the cell wall and causing the loss of cellular components, subsequently inhibiting the production of fumonisins and ergosterol.

  3. Relationship between napping during night shift work and household obligations of female nursing personnel. (United States)

    Silva-Costa, Aline; Fischer, Frida Marina; Griep, Rosane Harter; Rotenberg, Lúcia


    Night shift employment involves displacing sleep to the daytime. For female workers, the opportunity for daytime sleep is influenced by routine housework demands, which aggravates sleep deprivation. Allowing naps to be taken during the night shift of work is a frequent practice at some hospitals and can help reduce the effects of sleep deprivation. We hypothesize that an association between domestic work and the length of naps during night work exists for nursing professionals. To test this hypothesis, two cross-sectional studies were conducted in two different hospitals. In Study 1, female workers answered questionnaires regarding sleeping habits, professional work, and housework demands. In Study 2, data regarding napping during shifts was obtained by actigraphy, a noninvasive method of monitoring the human sleep-wake cycle. The demand for the performance of housework was measured by (i) domestic work hours (total time spent performing domestic work per week), and (ii) domestic workload, which considers the degree of sharing domestic tasks and the number of people living at home. The populations from the two studies were subdivided into groups, based on the duration of napping at work. Data on naps were analyzed according to domestic demands, using the Mann-Whitney and Chi-squared tests. Among the two study populations (Studies 1 and 2), those in Study 2 were older, had shorter professional weekly work hours, worked more night shifts, and dedicated more time to housework. significant associations were only found in Study 2, where greater time napping at work was associated with both greater time spent doing housework and greater domestic workload. The known benefits of napping during night shifts seem to be especially relevant for female workers who are more sleep-deprived from working more night shifts and who have higher demands for housework.

  4. Reconsidering the sporulation characteristics of hypervirulent Clostridium difficile BI/NAP1/027.

    Directory of Open Access Journals (Sweden)

    David A Burns

    Full Text Available Clostridium difficile is the leading cause of antibiotic-associated diarrhoea and a major burden to healthcare services worldwide. In recent years, C. difficile strains belonging to the BI/NAP1/027 type have become highly represented among clinical isolates. These so-called 'hypervirulent' strains are associated with outbreaks of increased disease severity, higher relapse rates and an expanded repertoire of antibiotic resistance. Spores, formed during sporulation, play a pivotal role in disease transmission and it has been suggested that BI/NAP1/027 strains are more prolific in terms of sporulation in vitro than 'non-epidemic' C. difficile types. Work in our laboratory has since provided credible evidence to the contrary suggesting that the strain-to-strain variation in C. difficile sporulation characteristics is not type-associated. However, the BI/NAP1/027 type is still widely stated to have an increased rate of sporulation. In this study, we analysed the sporulation rates of 53 C. difficile strains, the largest sample size used to-date in such a study, including 28 BI/NAP1/027 isolates. Our data confirm that significant variation exists in the rate at which different C. difficile strains form spores. However, we clearly show that the sporulation rate of the BI/NAP1/027 type was no higher than that of non-BI/NAP1/027 strains. In addition, we observed substantial variation in sporulation characteristics within the BI/NAP1/027 type. This work highlights the danger of assuming that all strains of one type behave similarly without studying adequate sample sizes. Furthermore, we stress the need for more rigorous experimental procedures in order to quantify C. difficile sporulation more accurately in the future.

  5. Eficiencia biológica de cepas nativas de Trichoderma spp., en el control de Sclerotium rolfsii Sacc., en cacahuate

    Directory of Open Access Journals (Sweden)

    A. C. Michel-Aceves


    Full Text Available En el control de Sclerotium rolfsii Sacc., se evaluó el efecto antagónico de aislados nativos de Trichoderma spp., bajo condiciones in vitro y de invernadero, en la zona Norte del estado de Guerrero. Se obtuvieron doce aislados nativos de Trichoderma spp. (dos de Santa Teresa y diez de Tlaxmalac, Gro., de los cuales se seleccionaron seis (Tcn-4, Tcn-5, Tcn-6, Tcn-7, Tcn-8 y Tcn-11 mediante el método del papel celofán. En condiciones in vitro, el porcentaje de inhibición varió desde 10 a 94.40%; registrándose mediante la técnica de cultivos apareados el antagonismo clase dos en el aislado Tcn-11; en estas condiciones, inhibió el crecimiento del fitopatógeno y evitó su desarrollo en el 80% de la superficie del medio en la caja de Petri. En condiciones de invernadero se evaluó la cepa nativa Tcn-11 identificada morfológica y genéticamente como T. harzianum Rifai y se comparó con una cepa de la colección (Thzcf-12 y un fungicida comercial en tres tiempos de inoculación. El fitopatógeno S. rolfsii no fue suficientemente agresivo para ocasionar la muerte de la planta de cacahuate; sin embargo, se observaron efectos negativos en su desarrollo y producción de semillas. Las cepas Tcn-11 y Thzcf-12 fueron capaces de contribuir al desarrollo de la planta de cacahuate y ayudar a protegerla de la infección de S. rolfsii de manera más eficiente que el fungicida pentacloro nitrobenceno (PCNB.

  6. Perspectivas del uso de bacterias rizosféricas en el control de pyricularia grisea (cooke sacc.) en el cultivo del arroz (oryza sativa l.)


    Acebo Guerrero, Yanelis; Hernández-Rodríguez, Annia; Rives Rodríguez, Narovis; Hernández-Lauzardo, Ana Niurka


    Prospect of the use of bacteria in the control Pyricularia grisea (Cooke Sacc.) on rice (Oriza sativa L.) Título corto: Bacterias rizosféricas para controlar la piriculariosis ResumenEl arroz es fuente de alimento para una gran parte de la población mundial, con alto promedio de consumo anual. En este cultivo las enfermedades de origen microbiano constituyen uno de los factores que inciden en la obtención de bajos rendimientos y calidad de los granos. La piriculariosis o añublo del arroz, cau...

  7. Perspectivas del uso de bacterias rizosféricas en el control de Pyricularia grisea (Cooke Sacc.) en el cultivo del arroz (Oryza sativa L.)


    Yanelis Acebo Guerrero; Annia Hernández-Rodríguez; Narovis Rives Rodríguez; Ana Niurka Hernández-Lauzardo


    Prospect of the use of bacteria in the control Pyricularia grisea (Cooke Sacc.) on rice (Oriza sativa L.) Título corto: Bacterias rizosféricas para controlar la piriculariosis ResumenEl arroz es fuente de alimento para una gran parte de la población mundial, con alto promedio de consumo anual. En este cultivo las enfermedades de origen microbiano constituyen uno de los factores que inciden en la obtención de bajos rendimientos y calidad de los granos. La piriculariosis o añublo del arroz, cau...

  8. Implantación de la 5S y de la metodología de aprendizaje SACC en una empresa de embalaje


    Rodríguez Almazán, Alejandro


    El presente proyecto trata sobre dos temas. El primero es la implantación de las 5S en una empresa de embalaje. El segundo, contribuir a la formación de esta metodología mediante el desarrollo de un seminario de aprendizaje SACC que aborde todos los aspectos necesarios para implantar las 5S. Para lograr la implantación necesitamos una visión general de las 5S y conocer los pasos previos para implantarla. Una vez hecho, el siguiente paso es evaluar el proceso de implantación. Con el seminar...

  9. Nap and melatonin-induced changes in hippocampal activation and their role in verbal memory consolidation. (United States)

    Gorfine, Tali; Yeshurun, Yaara; Zisapel, Nava


    Overnight sleep contributes to memory consolidation; even a short nap improves memory performance. Such improvement has been linked to hippocampal activity during sleep. Melatonin has been shown to affect the human hippocampus and to induce 'sleep like' changes in brain activation. We therefore conducted and compared two functional magnetic resonance imaging studies: the first study assessed the effect of a 2-hr mid-day nap versus an equal amount of wakefulness on a verbal memory task (unrelated word pair association); the second assessed the effect of melatonin versus placebo (both conditions without nap) on a similar task. We report that following a nap relative to wakefulness, successful retrieval-related activation in the parahippocampus is decreased. A smaller decrease is seen in wakefulness with melatonin but not placebo. In parallel, an improvement in verbal memory recall was found after a nap compared with wakefulness but not with melatonin during wakefulness compared with placebo. Our findings demonstrate effects of melatonin that resemble those of sleep on verbal memory processing in the hippocampus thus suggesting that melatonin, like sleep, can initiate offline plastic changes underlying memory consolidation; they also suggest that concomitant rest without interferences is necessary for enhanced performance.

  10. The effects of biperiden on nap sleep after sleep deprivation in depressed patients. (United States)

    Dressing, H; Riemann, D; Gann, H; Berger, M


    Sixteen patients with a major depressive disorder were allowed to take a nap at 5 A.M. after a period of total sleep deprivation. The patients were randomly assigned to biperiden or placebo treatment prior to the nap to test the hypothesis that anticholinergic medication is capable of preventing a nap-related worsening of mood. Total sleep deprivation positively influenced mood for the whole group. Contrary to expectations, the rate of nap-related relapses of mood did not differ between placebo- and biperiden-treated individuals, and biperiden did not significantly suppress rapid eye movement (REM) sleep. There was only a tendency for lower REM time after administration of biperiden compared to placebo. This unexpected result may be due to a high cholinergic tone in the patient group investigated and a high REM propensity in the early morning hours. Studies with more selective M1/M2 receptor antagonists are necessary to clarify whether nap-related changes of mood can be prevented by anticholinergic blockade.

  11. Nucleosome Assembly Protein 1-Like 1 (Nap1l1 Regulates the Proliferation of Murine Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Yuan Yan


    Full Text Available Background/Aims: To investigate whether nucleosome assembly protein 1-like 1 (Nap1l1 regulates the proliferation of induced pluripotent stem cells (iPSC and the potential mechanisms. Methods: Nap1l1-knockdown-iPSC and Nap1l1-overexpression-iPSC were constructed by transfection of lentiviral particles. The proliferation of iPSC was detected by MTT analysis, and cell cycle was analyzed by flow cytometry. Results: Nap1l1 overexpression promoted iPSC proliferation and induced G2/M transition compared to their control iPSC while Nap1l1-knockdown-iPSC dramatically displayed the reduced proliferation and accumulated G2/M phase cells. Further analysis showed that Nap1l1 overexpression in iPSC increased the expression of cyclin B1, downregulated the expression of p21 and p27, while knockdown of Nap1l1 showed the opposite effects. In addition, overexpression of Nap1l1 promoted the phosphorylation of AKT and ERK in iPSC, while knockdown of Nap1l1 inhibited the effects. However, these effects displayed in Nap1l1-overexpression-iPSC were greatly suppressed by the inhibition of AKT or ERK signaling. Conclusions: The results indicate that Nap1l1 promotes the proliferation of iPSC attributable to G2/M transition caused by downregulation of p27 and p21, and upregulation of cyclin B1, the activation of AKT or ERK is involved in the process. The present study has revealed a novel molecular mechanism involved in the proliferation of iPSC.

  12. Identification of seed-specific promoter nap300 and its comparison with 7S promoter

    Institute of Scientific and Technical Information of China (English)


    By fusing seed-specific promoter nap300 with β-glucuronidase gene, it was found that this about 300bp DNA fragment was sufficient to direct seed-specific gene expression. The substitution mutation in both distB and proxB elements had a little effect on the expression efficiency and almost no effect on the organ-specific expression pattern. In the experiment designed to compare nap300 with 7S promoter, the result showed that tissue specificity for nap300 was higher than that for 7S, and its expression level was lower than 7S's. There was no big difference in their expression pattern, and the maximal activity stage for the two promoters was identical, which indicated they could be used simultaneously for expressing different foreign genes in seeds.

  13. Toddler's self-regulation strategies in a challenge context are nap-dependent. (United States)

    Miller, Alison L; Seifer, Ronald; Crossin, Rebecca; Lebourgeois, Monique K


    Early childhood represents a time of developmental changes in both sleep and self-regulation, a construct reflecting the ability to control one's behaviour, attention and emotions when challenged. Links between sleep and self-regulation processes have been proposed, but experimental evidence with young children is lacking. In the current study, we tested the effects of acute sleep restriction (nap deprivation) on toddlers' self-regulation. Healthy children (n = 12; four males; aged 30-36 months (33.9 ± 1.7)) slept on a strict schedule (verified with actigraphy and sleep diaries) for 5 days before each of two afternoon assessments following a nap and a no-nap condition (~11-day protocol). Children were videotaped while attempting an unsolvable puzzle, and 10 mutually exclusive self-regulation strategies were later coded. On average, children lost ~90 min of sleep on the no-nap versus the nap day. Nap deprivation resulted in moderate-to-large effects on self-regulation strategies, with decreases in scepticism (d = 0.77; 7% change), negative self-appraisal (d = 0.92; 5% change) and increases in physical self-soothing (d = 0.68; 10% change), focus on the puzzle piece that would not fit (perseveration; d = 0.50; 9% change) and insistence on completing the unsolvable puzzle (d = 0.91; 10% change). Results suggest that sleep serves an important role in the way that toddlers respond to challenging events in their daily lives. After losing daytime sleep, toddlers were less able to engage effectively in a difficult task and reverted to less mature self-regulation strategies than when they were well rested. Over time, chronically missed sleep may impair young children's self-regulation abilities, resulting in risk for social-emotional, behavioural and school problems.

  14. Rapid-Eye-Movement-Sleep (REM Associated Enhancement of Working Memory Performance after a Daytime Nap.

    Directory of Open Access Journals (Sweden)

    Esther Yuet Ying Lau

    Full Text Available The main objective was to study the impact of a daytime sleep opportunity on working memory and the mechanism behind such impact. This study adopted an experimental design in a sleep research laboratory. Eighty healthy college students (Age:17-23, 36 males were randomized to either have a polysomnography-monitored daytime sleep opportunity (Nap-group, n=40 or stay awake (Wake-group, n=40 between the two assessment sessions. All participants completed a sleep diary and wore an actigraph-watch for 5 days before and one day after the assessment sessions. They completed the state-measurement of sleepiness and affect, in addition to a psychomotor vigilance test and a working memory task before and after the nap/wake sessions. The two groups did not differ in their sleep characteristics prior to and after the lab visit. The Nap-group had higher accuracy on the working memory task, fewer lapses on the psychomotor vigilance test and lower state-sleepiness than the Wake-group. Within the Nap-group, working memory accuracy was positively correlated with duration of rapid eye movement sleep (REM and total sleep time during the nap. Our findings suggested that "sleep gain" during a daytime sleep opportunity had significant positive impact on working memory performance, without affecting subsequent nighttime sleep in young adult, and such impact was associated with the duration of REM. While REM abnormality has long been noted in pathological conditions (e.g. depression, which are also presented with cognitive dysfunctions (e.g. working memory deficits, this was the first evidence showing working memory enhancement associated with REM in daytime napping in college students, who likely had habitual short sleep duration but were otherwise generally healthy.

  15. Rapid-Eye-Movement-Sleep (REM) Associated Enhancement of Working Memory Performance after a Daytime Nap. (United States)

    Lau, Esther Yuet Ying; Wong, Mark Lawrence; Lau, Kristy Nga Ting; Hui, Florence Wai Ying; Tseng, Chia-huei


    The main objective was to study the impact of a daytime sleep opportunity on working memory and the mechanism behind such impact. This study adopted an experimental design in a sleep research laboratory. Eighty healthy college students (Age:17-23, 36 males) were randomized to either have a polysomnography-monitored daytime sleep opportunity (Nap-group, n=40) or stay awake (Wake-group, n=40) between the two assessment sessions. All participants completed a sleep diary and wore an actigraph-watch for 5 days before and one day after the assessment sessions. They completed the state-measurement of sleepiness and affect, in addition to a psychomotor vigilance test and a working memory task before and after the nap/wake sessions. The two groups did not differ in their sleep characteristics prior to and after the lab visit. The Nap-group had higher accuracy on the working memory task, fewer lapses on the psychomotor vigilance test and lower state-sleepiness than the Wake-group. Within the Nap-group, working memory accuracy was positively correlated with duration of rapid eye movement sleep (REM) and total sleep time during the nap. Our findings suggested that "sleep gain" during a daytime sleep opportunity had significant positive impact on working memory performance, without affecting subsequent nighttime sleep in young adult, and such impact was associated with the duration of REM. While REM abnormality has long been noted in pathological conditions (e.g. depression), which are also presented with cognitive dysfunctions (e.g. working memory deficits), this was the first evidence showing working memory enhancement associated with REM in daytime napping in college students, who likely had habitual short sleep duration but were otherwise generally healthy.

  16. Performance of flash profile and napping with and without training for describing small sensory differences in a model wine

    DEFF Research Database (Denmark)

    Liu, Jing; Grønbeck, Marlene Schou; Di Monaco, Rosella


    characters and sensory intensities (weak to moderate). Some modifications to the classical Napping and Flash Profile protocols were employed in order to improve discriminability, repeatability and accuracy. The results showed that conducting Napping with a panel training on either the method (training on how...

  17. KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription (United States)

    Gupta, Namrata; Thakker, Suhani; Verma, Subhash C.


    The establishment of latency is an essential for lifelong persistence and pathogenesis of Kaposi’s sarcoma-associated herpesvirus (KSHV). Latency-associated nuclear antigen (LANA) is the most abundantly expressed protein during latency and is important for viral genome replication and transcription. Replication-coupled nucleosome assembly is a major step in packaging the newly synthesized DNA into chromatin, but the mechanism of KSHV genome chromatinization post-replication is not understood. Here, we show that nucleosome assembly protein 1-like protein 1 (NAP1L1) associates with LANA. Our binding assays revealed an association of LANA with NAP1L1 in KSHV-infected cells, which binds through its amino terminal domain. Association of these proteins confirmed their localization in specific nuclear compartments of the infected cells. Chromatin immunoprecipitation assays from NAP1L1-depleted cells showed LANA-mediated recruitment of NAP1L1 at the terminal repeat (TR) region of the viral genome. Presence of NAP1L1 stimulated LANA-mediated DNA replication and persistence of a TR-containing plasmid. Depletion of NAP1L1 led to a reduced nucleosome positioning on the viral genome. Furthermore, depletion of NAP1L1 increased the transcription of viral lytic genes and overexpression decreased the promoter activities of LANA-regulated genes. These results confirmed that LANA recruitment of NAP1L1 helps in assembling nucleosome for the chromatinization of newly synthesized viral DNA.

  18. Afternoon nap and bright light exposure improve cognitive flexibility post lunch.

    Directory of Open Access Journals (Sweden)

    Hichem Slama

    Full Text Available Beneficial effects of napping or bright light exposure on cognitive performance have been reported in participants exposed to sleep loss. Nonetheless, few studies investigated the effect of these potential countermeasures against the temporary drop in performance observed in mid-afternoon, and even less so on cognitive flexibility, a crucial component of executive functions. This study investigated the impact of either an afternoon nap or bright light exposure on post-prandial alterations in task switching performance in well-rested participants. Twenty-five healthy adults participated in two randomized experimental conditions, either wake versus nap (n=15, or bright light versus placebo (n=10. Participants were tested on a switching task three times (morning, post-lunch and late afternoon sessions. The interventions occurred prior to the post-lunch session. In the nap/wake condition, participants either stayed awake watching a 30-minute documentary or had the opportunity to take a nap for 30 minutes. In the bright light/placebo condition, participants watched a documentary under either bright blue light or dim orange light (placebo for 30 minutes. The switch cost estimates cognitive flexibility and measures task-switching efficiency. Increased switch cost scores indicate higher difficulties to switch between tasks. In both control conditions (wake or placebo, accuracy switch-cost score increased post lunch. Both interventions (nap or bright light elicited a decrease in accuracy switch-cost score post lunch, which was associated with diminished fatigue and decreased variability in vigilance. Additionally, there was a trend for a post-lunch benefit of bright light with a decreased latency switch-cost score. In the nap group, improvements in accuracy switch-cost score were associated with more NREM sleep stage N1. Thus, exposure to bright light during the post-lunch dip, a countermeasure easily applicable in daily life, results in similar

  19. Functional roles of CymA and NapC in reduction of nitrate and nitrite by Shewanella putrefaciens W3-18-1

    Energy Technology Data Exchange (ETDEWEB)

    Beliav, Alex; Qiu, Dongru; Fredrickson, James K.; Wei, Hehong; Nealson, Kenneth H.; Xia, Ming; Zhou, Jizhong; Dai, Jingcheng; Shi, Liang; Tiedje, James M.; Romine, Margaret F.


    Shewanella putrefaciens W3-18-1 harbours two periplasmic nitrate reductase (Nap) gene clusters, NapC-associated nap-alpha (napEDABC) and CymA-dependent nap-beta (napDAGHB), for dissimilatory nitrate respiration. CymA is a member of the NapC/NirT quinol dehydrogenase family and acts as a hub to support different respiratory pathways, including those on iron [Fe(III)] and manganese [Mn(III, IV)] (hydr)oxide, nitrate, nitrite, fumarate and arsenate in Shewanella strains. However, in our analysis it was shown that another NapC/NirT family protein, NapC, was only involved in nitrate reduction, although both CymA and NapC can transfer quinol-derived electrons to a periplasmic terminal reductase or an electron acceptor. Furthermore, our results showed that NapC could only interact specifically with the Nap-alpha nitrate reductase while CymA could interact promiscuously with Nap-alpha, Nap-beta and the NrfA nitrite reductase for nitrate and nitrite reduction. To further explore the difference in specificity, site-directed mutagenesis on both CymA and NapC was conducted and the phenotypic changes in nitrate and nitrite reduction were tested. Our analyses demonstrated that the Lys-91 residue played a key role in nitrate reduction for quinol oxidation and the Asp-166 residue might influence the maturation of CymA. The Asp-97 residue might be one of the key factors that influence the interaction of CymA with the cytochromes NapB and NrfA.

  20. How to Reform Napping System in China%论午睡在我国的改革

    Institute of Scientific and Technical Information of China (English)



    In this paper, we first point out that when people take napping daily, they get some benefits and losses as well. With the development of China, the losses of napping are overweighing the benefits of napping,therefore,now it is necessary to reform the napping system in China. In the last part of the paper, we give some suggestions on how to reform the napping system in China.%文章首先分析了午睡的有利作用和不利影响,然后指出随着社会的进步,午睡的必要作用在降低,而午睡的弊端却越来越严重,有必要对我国的午睡进行改革。文中最后提出了在我国实行午睡改革的建议。

  1. ADNP/NAP dramatically increase microtubule end-binding protein-Tau interaction: a novel avenue for protection against tauopathy. (United States)

    Ivashko-Pachima, Y; Sayas, C Laura; Malishkevich, A; Gozes, I


    Activity-dependent neuroprotective protein (ADNP), vital for brain formation and cognitive function, is mutated in autism and linked to neurodegenerative/psychiatric diseases. An eight-amino-acid peptide snippet of ADNP, NAP (NAPVSIPQ), identified as a smallest active fragment, includes the SxIP microtubule (MT) end-binding protein (EB) association motif, and enhances ADNP-EB3 interaction. Depletion of EB1 or EB3 abolishes NAP protection against zinc intoxication. Furthermore, NAP enhances Tau-MT interaction, and Tau regulates the localization and function of EB1 and EB3 in developing neuronal cells. Here, we asked how NAP (ADNP) enhances Tau-MT interactions and whether this is mediated by EBs. We showed, for we believe the first time, that NAP augmented endogenous EB1 comet density in the N1E-115 neuroblastoma neuronal model. This finding was substantiated by cell transfection with fluorescent EB1 and live cell imaging. NAP increased comet amounts, length and speed. At the molecular level, NAP enhanced EB3 homodimer formation, while decreasing EB1-EB3 heterodimer content and driving EB1- and EB3-Tau interactions (dramatic 20-fold increases), leading to recruitment of EB1/EB3 and Tau to MTs under zinc intoxication. Our previous results showed that while NAP protected neuronal-like cells against oxidative stress, it did not protect NIH3T3 fibroblasts. Here, NAP did not protect NIH3T3 cells against zinc intoxication, unless these cells were transfected with Tau. Interestingly, other MT associated proteins (MAPs) may replace Tau, thus, EB-Tau (MAPs) interaction is identified as a novel target for endogenous ADNP neuroprotection, and a future target for drug development, with NAP as a prototype.Molecular Psychiatry advance online publication, 24 January 2017; doi:10.1038/mp.2016.255.

  2. Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. (United States)

    Fang, Guoliang; Zhang, Dachuan; Yin, Huilong; Zheng, Lu; Bi, Xiaolin; Yuan, Li


    Centrosome cohesion, mostly regarded as a proteinaceous linker between parental centrioles, ensures that the interphase centrosome(s) function as a single microtubule-organizing center. Impairment of centrosome cohesion leads to the splitting of centrosomes. Although the list of cohesion proteins is growing, the precise composition and regulation of centrosome cohesion are still largely unknown. In this study, we show that the centriolar protein centlein (also known as CNTLN) localizes to the proximal ends of the centrioles and directly interacts with both C-Nap1 (also known as Cep250) and Cep68. Moreover, centlein complexes with C-Nap1 and Cep68 at the proximal ends of centrioles during interphase and functions as a molecular link between C-Nap1 and Cep68. Depletion of centlein impairs recruitment of Cep68 to the centrosomes and, in turn, results in centrosome splitting. Both centlein and Cep68 are novel Nek2A substrates. Collectively, our data demonstrate that centrosome cohesion is maintained by the newly identified complex of C-Nap1-centlein-Cep68.

  3. Effects of ethanol and NAP on cerebellar expression of the neural cell adhesion molecule L1.

    Directory of Open Access Journals (Sweden)

    Devon M Fitzgerald

    Full Text Available The neural cell adhesion molecule L1 is critical for brain development and plays a role in learning and memory in the adult. Ethanol inhibits L1-mediated cell adhesion and neurite outgrowth in cerebellar granule neurons (CGNs, and these actions might underlie the cerebellar dysmorphology of fetal alcohol spectrum disorders. The peptide NAP potently blocks ethanol inhibition of L1 adhesion and prevents ethanol teratogenesis. We used quantitative RT-PCR and Western blotting of extracts of cerebellar slices, CGNs, and astrocytes from postnatal day 7 (PD7 rats to investigate whether ethanol and NAP act in part by regulating the expression of L1. Treatment of cerebellar slices with 20 mM ethanol, 10(-12 M NAP, or both for 4 hours, 24 hours, and 10 days did not significantly affect L1 mRNA and protein levels. Similar treatment for 4 or 24 hours did not regulate L1 expression in primary cultures of CGNs and astrocytes, the predominant cerebellar cell types. Because ethanol also damages the adult cerebellum, we studied the effects of chronic ethanol exposure in adult rats. One year of binge drinking did not alter L1 gene and protein expression in extracts from whole cerebellum. Thus, ethanol does not alter L1 expression in the developing or adult cerebellum; more likely, ethanol disrupts L1 function by modifying its conformation and signaling. Likewise, NAP antagonizes the actions of ethanol without altering L1 expression.

  4. Kas kirik peaks tänapäevastuma? / Jaan Lahe

    Index Scriptorium Estoniae

    Lahe, Jaan, 1971-


    Autori sõnade kohaselt ei pea kirik olema konservatiivne ega vastandama end muule ühiskonnale, vaid võib olla avatud ka tänapäevasele mõtlemisele ja vaimsusele. Fundamentalismist kui konservatiivsest usukäsitlusest

  5. Mis on "Tänapäeva apokalüpsis"? / Kalmer Saar

    Index Scriptorium Estoniae

    Saar, Kalmer


    Francis Ford Coppola suurfilmi "Tänapäeva apokalüpsis" autoriversioon "Apocalypse Now Redux" (Ameerika Ühendriigid 2001/1979) lõpetab USA kultusfilmide festivali kinos "Sõprus". Lisa : Jaan Ruusi "Apocalypse Now Redux" selgitab autoriversiooni - director's cut - mõistet

  6. napäeva muinasjutt : [lühijutud] / Kris, Moor, pseud.

    Index Scriptorium Estoniae

    Kris Moor, pseud.


    Sisu: Imagine an actor saying following ; algus ; korralikud tüdrukud ; Provokatsioon ; absoluutselt täiuslik ; sigaret ; best friends ; probleem ; Tere Kris ; kirjutis ; armastus ; Elluastuja ; oeh ; klishee ; happy neverending story ; tungid ja tungisaatused ; noh ; lohe ; the art of noise ; latentsus ; Lühikokkuvõte tänapäeva muinasjutust: (ilma ilukirjandusliku liialduseta)

  7. Structure and immunomodulatory property relationship in NapA of Borrelia burgdorferi. (United States)

    Codolo, Gaia; Papinutto, Elena; Polenghi, Alessandra; D'Elios, Mario Milco; Zanotti, Giuseppe; de Bernard, Marina


    NapA from Borrelia burgdorferi is a member of the Dps-like protein family with specific immunomodulatory properties; in particular, NapA is able to induce the expression of IL-23 in neutrophils and monocytes, as well as the expression of IL-6, IL-1β, and transforming growth factor beta (TGF-β) in monocytes, via Toll-like receptor (TLR) 2. Such an activity on innate immune cells triggers a synovial fluid Th17 response. Here we report the crystal structure of NapA, determined at 2.6Å resolution, which shows that the quaternary structure of the protein is that of a dodecamer with 23 symmetry, typical of the proteins of the family. We also demonstrate that the N- and C-terminal tails, which are flexible and not visible in the crystal, are not relevant for its pro-Th17 activity. Based on the crystal structure and on the comparison with the structure of the orthologous protein from Helicobacter pylori, HP-NAP, we hypothesize that the charge distributions on the two proteins' surfaces are responsible for the interaction with TLR2 and for the different behaviors in modulating the immune response.

  8. [Association between insomnia symptoms, daytime napping, and falls in community-dwelling elderly]. (United States)

    Pereira, Alexandre Alves; Ceolim, Maria Filomena; Neri, Anita Liberalesso


    This study focused on associations between insomnia symptoms, daytime napping, and falls in community-dwelling elderly, using a population-based cross-sectional design and probability sample with 689 community-dwelling elders. The protocol consisted of self-reported and physical performance variables. The study used univariate and multivariate logistic regression analysis with statistical significance set at p insomnia symptoms and daytime napping were 49.9% (n = 339) and 62.8% (n = 432), respectively. 14.4% reported a single fall and 11.9% reported multiple falls. Falls were associated with female gender (OR = 7.73; 95%CI: 3.03-19.72), age > 80 (OR = 3.48; 95%CI: 1.54-7.85), napping (OR = 2.24; 95%CI: 1.24-4.05), and depressive symptoms (OR = 1.98; 95%CI: 1.11-3.53). The association between daytime napping and falls corroborates data from international research. Identifying modifiable risk factors may help programs to prevent falls in the elderly.

  9. Relationship between napping during night shift work and household obligations of female nursing personnel

    Directory of Open Access Journals (Sweden)

    Silva Costa A


    Full Text Available Aline Silva-Costa,1,2 Frida Marina Fischer,1 Rosane Harter Griep,2 Lúcia Rotenberg2 1School of Public Health, University of São Paulo, São Paulo, Brazil; 2Laboratory of Health, Environment and Education, Oswaldo Cruz Institute (Fiocruz, Rio de Janeiro, Brazil Abstract: Night shift employment involves displacing sleep to the daytime. For female workers, the opportunity for daytime sleep is influenced by routine housework demands, which aggravates sleep deprivation. Allowing naps to be taken during the night shift of work is a frequent practice at some hospitals and can help reduce the effects of sleep deprivation. We hypothesize that an association between domestic work and the length of naps during night work exists for nursing professionals. To test this hypothesis, two cross-sectional studies were conducted in two different hospitals. In Study 1, female workers answered questionnaires regarding sleeping habits, professional work, and housework demands. In Study 2, data regarding napping during shifts was obtained by actigraphy, a noninvasive method of monitoring the human sleep–wake cycle. The demand for the performance of housework was measured by (i domestic work hours (total time spent performing domestic work per week, and (ii domestic workload, which considers the degree of sharing domestic tasks and the number of people living at home. The populations from the two studies were subdivided into groups, based on the duration of napping at work. Data on naps were analyzed according to domestic demands, using the Mann–Whitney and Chi-squared tests. Among the two study populations (Studies 1 and 2, those in Study 2 were older, had shorter professional weekly work hours, worked more night shifts, and dedicated more time to housework. Significant associations were only found in Study 2, where greater time napping at work was associated with both greater time spent doing housework and greater domestic workload. The known benefits of

  10. Napping in older people 'at risk' of dementia: relationships with depression, cognition, medical burden and sleep quality. (United States)

    Cross, Nathan; Terpening, Zoe; Rogers, Naomi L; Duffy, Shantel L; Hickie, Ian B; Lewis, Simon J G; Naismith, Sharon L


    Sleep disturbance is prevalent in older adults, particularly so in those at a greater risk of dementia. However, so far the clinical, medical and neuropsychological correlates of daytime sleep have not been examined. The aims of this study were to investigate the characteristics and effects of napping using actigraphy in older people, particularly in those 'at risk' of dementia. The study used actigraphy and sleep diaries to measure napping habits in 133 older adults 'at risk' of dementia (mean age = 65.5 years, SD = 8.4 years), who also underwent comprehensive medical, psychiatric and neuropsychological assessment. When defined by actigraphy, napping was present in 83.5% (111/133) of participants; however, duration and timing varied significantly among subjects. Nappers had significantly greater medical burden and body mass index, and higher rates of mild cognitive impairment. Longer and more frequent naps were associated with poorer cognitive functioning, as well as higher levels of depressive symptoms, while the timing of naps was associated with poorer nocturnal sleep quality (i.e. sleep latency and wake after sleep onset). This study highlights that in older adults 'at risk' of dementia, napping is associated with underlying neurobiological changes such as depression and cognition. Napping characteristics should be more routinely monitored in older individuals to elucidate their relationship with psychological and cognitive outcomes.

  11. Cloning and characterization of Arabidopsis thaliana AtNAP57--a homologue of yeast pseudouridine synthase Cbf5p. (United States)

    Maceluch, J; Kmieciak, M; Szweykowska-Kulińska, Z; Jarmołowski, A


    Rat Nap57 and its yeast homologue Cbf5p are pseudouridine synthases involved in rRNA biogenesis, localized in the nucleolus. These proteins, together with H/ACA class of snoRNAs compose snoRNP particles, in which snoRNA guides the synthase to direct site-specific pseudouridylation of rRNA. In this paper we present an Arabidopsis thaliana protein that is highly homologous to Cbf5p (72% identity and 85% homology) and NAP57 (67% identity and 81% homology). Moreover, the plant protein has conserved structural motifs that are characteristic features of pseudouridine synthases of the TruB class. We have named the cloned and characterized protein AtNAP57 (Arabidopsis thaliana homologue of NAP57). AtNAP57 is a 565 amino-acid protein and its calculated molecular mass is 63 kDa. The protein is encoded by a single copy gene located on chromosome 3 of the A. thaliana genome. Interestingly, the AtNAP57 gene does not contain any introns. Mutations in the human DKC1 gene encoding dyskerin (human homologue of yeast Cbf5p and rat NAP57) cause dyskeratosis congenita a rare inherited bone marrow failure syndrome characterized by abnormal skin pigmentation, nail dystrophy and mucosal leukoplakia.


    Directory of Open Access Journals (Sweden)

    Debabrata Maity


    Full Text Available Cordyceps sinensis (Berk. Sacc. is commonly known as ‘Caterpillar Fungus’ as it is parasitic on the larvae of different insects of Dipters and Lepidoptera groups. This fungus is of great medicinal value. The whole range of Himalayas, particularly the eastern region is the native place of this taxon. Sikkim, a tiny beautiful state of India also harbours this fungus in some specific high altitude areas (4000-5500 m. The stromatic part develops from the head of the caterpillar having pungent odour even when dried. The ethnic communities of Sikkim, viz. Lapchas, Nepalese, Bhutias, Sherpas etc. use this organism for the remedy of different physical disorders including sexual impotency. It has also some effect on wild animals like Yak. The traditional uses, of this fungus by different tribal communities of North Sikkim including its other medicinal uses and conservation aspects are described.

  13. Identification of Cordyceps sinensis (Berk.) Sacc. And Its Analogues%冬虫夏草及其类似品的鉴别研究

    Institute of Scientific and Technical Information of China (English)



    冬虫夏草Cordyceps sinensis(Berk.)Sacc.是一种常用名贵药材,虫草的现代研究成果又促其需求量急剧增大,虫草的三种地方习用品(类似品)作虫草药用已有报道.笔者经过实地调查和查阅大量文献发现类似品有七种之多,其中一种江安虫草从未公开报道,现归纳成文,以便同行们参考和进一步研究.

  14. Variación patogénica y fuentes de resistencia a Colletotrichum lindemuthianum Sacc & magn Scrib., patógeno de la antracnosis del frijol, en Colombia Variación patogénica y fuentes de resistencia a Colletotrichum lindemuthianum (Sacc & Magn Scrib., patógeno de la antracnosis del fríjol, en Colombia

    Directory of Open Access Journals (Sweden)

    Cobo S. Felipe


    Full Text Available Pathogenic variation studies with colombian isolates of Colletotrichum lindemuthianum (Sacc & Magn Scrib., the anthracnose bean pathogen, were conducted under laboratory and greenhouse conditions at CIAT, Colombia. In addition, bean germplam with cormercial grain color was evaluated with the objective of identifying resistant varieties and sources of resistance to the existing variation. To this purpose, 17 isolates of C. lindemuthianum collected at the principal Colombian bean zones, were inoculated on 21 American and European differential bean varieties.En los laboratorios e invernaderos del programa de fitopatología de fríjol del CIAT, se estudió la variación patogénica de aislamientos colombianos de Colletotrichum lindemuthianum (Sacc& Magn Scrib. También se evaluó germoplasma de frijol con grano de color comercial con el objetivo de identificar líneas resistentes y fuentes de resistencia a la variación existente. Para este fin, 17 aislamientos de C.lindemuthianum, colectados en las principales zonas frijoleras colombianas se inocularon sobre 21 variedades diferenciales.

  15. Slow wave sleep during a daytime nap is necessary for protection from subsequent interference and long-term retention. (United States)

    Alger, Sara E; Lau, Hiuyan; Fishbein, William


    While it is now generally accepted that sleep facilitates the processing of newly acquired declarative information, questions still remain as to the type and length of sleep necessary to best benefit declarative memories. A better understanding could lend support in one direction or another as to the much-debated role of sleep, be it passive, permissive, or active, in memory processing. The present study employed a napping paradigm and compared performance on a bimodal paired-associates task of those who obtained a 10-min nap, containing only Stages 1 and 2 sleep, to those whose nap contained slow-wave sleep (SWS) and rapid eye movement (REM) sleep (60-min nap), as well as to subjects who remained awake. Measurements were obtained for baseline performance at training, after a sleep/no sleep interval for short-term retention, after a subsequent stimulus-related interference task, and again after a weeklong retention period. While all groups learned the information similarly, both nap groups performed better than the Wake group when examining short-term retention, approximately 1.5h after training (10-min p=.052, 60-min p=.002). However, performance benefits seen in the 10-min nap group proved to be temporary. Performance after a stimulus-related interference task revealed significantly better memory retention in the 60-min nap group, with interference disrupting the memory trace far less than both the Wake and 10-min nap groups (pconsolidation of learned bimodal paired-associates, supported by theories such as the Standard Theory of Consolidation as well as the Synaptic Homeostasis Hypothesis.

  16. Nap1: taking a closer look at a juggler protein of extraordinary skills. (United States)

    Zlatanova, Jordanka; Seebart, Corrine; Tomschik, Miroslav


    The nucleosome assembly protein Nap1 is used extensively in the chromatin field to reconstitute nucleosomal templates for structural and functional studies. Beyond its role in facilitating experimental investigation of nucleosomes, the highly conserved Nap1 is one of the best-studied members of the histone chaperone group. Here we review its numerous functions, focusing mainly on its roles in assembly and disassembly of the nucleosome particle, and its interactions with chromatin remodeling factors. Its presumed role in transcription through chromatin is also reviewed in detail. An attempt is made to clearly discriminate between fact and fiction, and to formulate the unresolved questions that need further attention. It is beyond doubt that the numerous, seemingly unrelated functions of this juggler protein have to be precisely channeled, coordinated, and regulated. Why nature endowed this specific protein with so many functions may remain a mystery. We are aware of the enormous challenge to the scientific community that understanding the mechanisms underlying these activities presents.

  17. Delayed onset of a daytime nap facilitates retention of declarative memory.

    Directory of Open Access Journals (Sweden)

    Sara E Alger

    Full Text Available BACKGROUND: Learning followed by a period of sleep, even as little as a nap, promotes memory consolidation. It is now generally recognized that sleep facilitates the stabilization of information acquired prior to sleep. However, the temporal nature of the effect of sleep on retention of declarative memory is yet to be understood. We examined the impact of a delayed nap onset on the recognition of neutral pictorial stimuli with an added spatial component. METHODOLOGY/PRINCIPAL FINDINGS: Participants completed an initial study session involving 150 neutral pictures of people, places, and objects. Immediately following the picture presentation, participants were asked to make recognition judgments on a subset of "old", previously seen, pictures versus intermixed "new" pictures. Participants were then divided into one of four groups who either took a 90-minute nap immediately, 2 hours, or 4 hours after learning, or remained awake for the duration of the experiment. 6 hours after initial learning, participants were again tested on the remaining "old" pictures, with "new" pictures intermixed. CONCLUSIONS/SIGNIFICANCE: Interestingly, we found a stabilizing benefit of sleep on the memory trace reflected as a significant negative correlation between the average time elapsed before napping and decline in performance from test to retest (p = .001. We found a significant interaction between the groups and their performance from test to retest (p = .010, with the 4-hour delay group performing significantly better than both those who slept immediately and those who remained awake (p = .044, p = .010, respectively. Analysis of sleep data revealed a significant positive correlation between amount of slow wave sleep (SWS achieved and length of the delay before sleep onset (p = .048. The findings add to the understanding of memory processing in humans, suggesting that factors such as waking processing and homeostatic increases in need for sleep over time modulate

  18. Illustratsioon eesti tänapäevases täiskasvanute ilukirjanduses / Martin Tõnts

    Index Scriptorium Estoniae

    Tõnts, Martin


    Uuritakse illustratsiooni funktsioone tänapäevases eesti ilukirjanduses, kas ja kuidas on need seotud tekstiga, on sellest inspireeritud või ei, kuivõrd annavad edasi tekstis peituvat või iseseisvat informatsiooni või on pelgalt kaunistavad, nagu peamiselt luulekogudes esinevad illustratsioonid. Praktilise tööna on Birk Rohelennu "Alexander ja Belle" raamatu kujundus, küljendus ja illustratsioonid

  19. Removal of Ca2+ and Zn2+ from aqueous solutions by zeolites NaP and KP. (United States)

    Yusof, Alias Mohd; Malek, Nik Ahmad Nizam Nik; Kamaruzaman, Nurul Asyikin; Adil, Muhammad


    Zeolites P in sodium (NaP) and potassium (KP) forms were used as adsorbents for the removal of calcium (Ca2+) and zinc (Zn2+) cations from aqueous solutions. Zeolite KP was prepared by ion exchange of K+ with Na+ which neutralizes the negative charge of the zeolite P framework structure. The ion exchange capacity of K+ on zeolite NaP was determined through the Freundlich isotherm equilibrium study. Characterization of zeolite KP was determined using infrared spectroscopy and X-ray diffraction (XRD) techniques. From the characterization, the structure of zeolite KP was found to remain stable after the ion exchange process. Zeolites KP and NaP were used for the removal of Ca and Zn from solution. The amount of Ca2+ and Zn2+ in aqueous solution before and after the adsorption by zeolites was analysed using the flame atomic absorption spectroscopy method. The removal of Ca2+ and Zn2+ followed the Freundlich isotherm rather than the Langmuir isotherm model. This result also revealed that zeolite KP adsorbs Ca2+ and Zn2+ more than zeolite NaP and proved that modification of zeolite NaP with potassium leads to an increase in the adsorption efficiency of the zeolite. Therefore, the zeolites NaP and KP can be used for water softening (Ca removal) and reducing water pollution/toxicity (Zn removal).

  20. NapA protects Helicobacter pylori from oxidative stress damage, and its production is influenced by the ferric uptake regulator. (United States)

    Cooksley, Clare; Jenks, Peter J; Green, Andrew; Cockayne, Alan; Logan, Robert P H; Hardie, Kim R


    The Helicobacter pylori protein NapA has been identified as a homologue of the Escherichia coli protein Dps. It is shown in this study that, like Dps, NapA is produced maximally in stationary phase cells and contributes to the ability of H. pylori to survive under oxidative stress conditions. Moreover, NapA co-localizes with the nuclear material, suggesting that it can interact with DNA in vivo. Furthermore, it is demonstrated that repression of NapA production by iron starvation was not so pronounced in a H. pylori fur mutant, suggesting that the ferric uptake regulator (Fur) is involved in napA regulation, and a potential fur box by which this control could be mediated is identified. This finding is consistent with the regulation of iron-binding proteins by Fur and also the modulation of Fur during oxidative stress, thus allowing NapA levels to be increased in the environmental conditions under which its ability to protect DNA from attack by toxic free radicals is most beneficial to the cell.

  1. Recovery of subsampled dimensions and configurations derived from napping data by MFA and MDS. (United States)

    Nestrud, Michael A; Lawless, Harry T


    Napping is a multivariate sensory method in which participants physically place stimuli on a large sheet of paper and orient them so that the distance between pairs represents a measure of dissimilarity. The two-dimensional nature of the task may be a limitation to the ability of this and similar methodologies to recover information about complex stimuli. In the first investigation, eight simulated three-dimensional stimuli were created with two different levels for each attribute. Simulated napping experiments had groups of participants attend to two of the dimensions with different probabilities. Multiple factor analysis (an analytical multivariate statistical procedure that can be thought of as a principle components analysis on the individuals) and MDS-INDSCAL (a variation on multidimensional scaling that finds a common configuration through reducing a stress measure associated with lack of fit) recovered full dimensionality from these data, although MFA had trouble when attention was the most unbalanced. In the second experiment, a human napping experiment was designed using custom three-dimensional stimuli: shapes with two levels each of size, color, and shape attributes. This experiment confirmed the results of Experiment 1, as both MDS-INDSCAL and MFA analyses again recovered the full dimensionality of the stimuli.

  2. Napping to renew learning capacity: enhanced encoding after stimulation of sleep slow oscillations. (United States)

    Antonenko, Daria; Diekelmann, Susanne; Olsen, Cathrin; Born, Jan; Mölle, Matthias


    As well as consolidating memory, sleep has been proposed to serve a second important function for memory, i.e. to free capacities for the learning of new information during succeeding wakefulness. The slow wave activity (SWA) that is a hallmark of slow wave sleep could be involved in both functions. Here, we aimed to demonstrate a causative role for SWA in enhancing the capacity for encoding of information during subsequent wakefulness, using transcranial slow oscillation stimulation (tSOS) oscillating at 0.75 Hz to induce SWA in healthy humans during an afternoon nap. Encoding following the nap was tested for hippocampus-dependent declarative materials (pictures, word pairs, and word lists) and procedural skills (finger sequence tapping). As compared with a sham stimulation control condition, tSOS during the nap enhanced SWA and significantly improved subsequent encoding on all three declarative tasks (picture recognition, cued recall of word pairs, and free recall of word lists), whereas procedural finger sequence tapping skill was not affected. Our results indicate that sleep SWA enhances the capacity for encoding of declarative materials, possibly by down-scaling hippocampal synaptic networks that were potentiated towards saturation during the preceding period of wakefulness.

  3. The differential effects of emotional salience on direct associative and relational memory during a nap. (United States)

    Alger, Sara E; Payne, Jessica D


    Relational memories are formed from shared components between directly learned memory associations, flexibly linking learned information to better inform future judgments. Sleep has been found to facilitate both direct associative and relational memories. However, the impact of incorporating emotionally salient information into learned material and the interaction of emotional salience and sleep in facilitating both types of memory is unknown. Participants encoded two sets of picture pairs, with either emotionally negative or neutral objects paired with neutral faces. The same objects were present in both sets, paired with two different faces across the sets. Baseline memory for these directly paired associates was tested immediately after encoding, followed by either a 90-min nap opportunity or wakefulness. Five hours after learning, a surprise test assessed relational memory, the indirect association between two faces paired with the same object during encoding, followed by a retest of direct associative memory. Overall, negative information was remembered better than neutral for directly learned pairs. A nap facilitated both preservation of direct associative memories and formation of relational memories, compared to remaining awake. Interestingly, however, this sleep benefit was observed specifically for neutral directly paired associates, while both neutral and negative relational associations benefitted from a nap. Finally, REM sleep played opposing roles in neutral direct and relational associative memory formation, with more REM sleep leading to forgetting of direct associations but promoting relational associations, suggesting that, while not benefitting memory consolidation for directly learned details, REM sleep may foster the memory reorganization needed for relational memory.

  4. Silencing of the SlNAP7 gene influences plastid development and lycopene accumulation in tomato (United States)

    Fu, Da-Qi; Meng, Lan-Huan; Zhu, Ben-Zhong; Zhu, Hong-Liang; Yan, Hua-Xue; Luo, Yun-Bo


    Ripening is an important stage of fruit development. To screen the genes associated with pigment formation in tomato fruit, a suppression subtractive hybridization (SSH) cDNA library was constructed by using tomato fruit in the green ripe and break ripe stages, and 129 differential genes were obtained. Using redness as a screening marker, virus-induced gene silencing (VIGS) of the differential genes was performed with a sprout vacuum-infiltration system (SVI). The results showed that silencing the SlNAP7 gene affected the chloroplast development of tomato leaves, manifesting as a photo-bleaching phenotype, and silenced fruit significantly affected the accumulation of lycopene, manifested as a yellow phenotype. In our study, we found that silencing the SlNAP7 gene downregulates the expression of the POR and PORA genes and destroys the normal development of the chloroplast. The expression of related genes included in the lycopene biosynthesis pathway was not significantly changed, but lycopene accumulation was significantly reduced in tomato fruit. Perhaps it was caused by the destruction of the chromoplast, which leads to the oxidation of lycopene. The results show that the SlNAP7 gene influences chloroplast development and lycopene accumulation in tomato.

  5. Predominance and high antibiotic resistance of the emerging Clostridium difficile genotypes NAPCR1 and NAP9 in a Costa Rican hospital over a 2-year period without outbreaks. (United States)

    López-Ureña, Diana; Quesada-Gómez, Carlos; Montoya-Ramírez, Mónica; del Mar Gamboa-Coronado, María; Somogyi, Teresita; Rodríguez, César; Rodríguez-Cavallini, Evelyn


    Clostridium difficile is the major causative agent of nosocomial antibiotic-associated diarrhea. In a 2009 outbreak of C. difficile-associated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent NAP1 strain (45%) predominated together with a local genotype variant (NAPCR1, 31%). Both strains were fluoroquinolone-resistant and the NAPCR1 genotype, in addition, was resistant to clindamycin and rifampicin. We now report on the genotypes and antibiotic susceptibilities of 68 C. difficile isolates from a major Costa Rican hospital over a 2-year period without outbreaks. In contrast to our previous findings, no NAP1 strains were detected, and for the first time in a Costa Rican hospital, a significant fraction of the isolates were NAP9 strains (n=14, 21%). The local NAPCR1 genotype remained prevalent (n=18, 26%) and coexisted with 14 strains (21%) of classic hospital NAP types (NAP2, NAP4, and NAP6), eight new genotypes (12%), four environmental strains classified as NAP10 or NAP11 (6%), three strains without NAP designation (4%) and seven non-toxigenic strains (10%). All 68 strains were resistant to ciprofloxacin, 88% were resistant to clindamycin and 50% were resistant to moxifloxacin and rifampicin. Metronidazole and vancomycin susceptibilities were universal. The NAPCR1 and NAP9 strains, which have been associated with more severe clinical infections, were more resistant to antibiotics than the other strains. Altogether, our results confirm that the epidemiology of C. difficile infection is dynamic and that A(-)B(+) strains from the NAP9 type are on the rise not only in the developed world. Moreover, our results reveal that the local NAPCR1 strains still circulate in the country without causing outbreaks but with equally high antibiotic-resistance rates and levels.

  6. J-curve relation between daytime nap duration and type 2 diabetes or metabolic syndrome: A dose-response meta-analysis. (United States)

    Yamada, Tomohide; Shojima, Nobuhiro; Yamauchi, Toshimasa; Kadowaki, Takashi


    Adequate sleep is important for good health, but it is not always easy to achieve because of social factors. Daytime napping is widely prevalent around the world. We performed a meta-analysis to investigate the association between napping (or excessive daytime sleepiness: EDS) and the risk of type 2 diabetes or metabolic syndrome, and to quantify the potential dose-response relation using cubic spline models. Electronic databases were searched for articles published up to 2016, with 288,883 Asian and Western subjects. Pooled analysis revealed that a long nap (≥60 min/day) and EDS were each significantly associated with an increased risk of type 2 diabetes versus no nap or no EDS (odds ratio 1.46 (95% CI 1.23-1.74, p Dose-response meta-analysis showed a J-curve relation between nap time and the risk of diabetes or metabolic syndrome, with no effect of napping up to about 40 minutes/day, followed by a sharp increase in risk at longer nap times. In summary, longer napping is associated with an increased risk of metabolic disease. Further studies are needed to confirm the benefit of a short nap.

  7. REM-Enriched Naps Are Associated with Memory Consolidation for Sad Stories and Enhance Mood-Related Reactivity. (United States)

    Gilson, Médhi; Deliens, Gaétane; Leproult, Rachel; Bodart, Alice; Nonclercq, Antoine; Ercek, Rudy; Peigneux, Philippe


    Emerging evidence suggests that emotion and affect modulate the relation between sleep and cognition. In the present study, we investigated the role of rapid-eye movement (REM) sleep in mood regulation and memory consolidation for sad stories. In a counterbalanced design, participants (n = 24) listened to either a neutral or a sad story during two sessions, spaced one week apart. After listening to the story, half of the participants had a short (45 min) morning nap. The other half had a long (90 min) morning nap, richer in REM and N2 sleep. Story recall, mood evolution and changes in emotional response to the re-exposure to the story were assessed after the nap. Although recall performance was similar for sad and neutral stories irrespective of nap duration, sleep measures were correlated with recall performance in the sad story condition only. After the long nap, REM sleep density positively correlated with retrieval performance, while re-exposure to the sad story led to diminished mood and increased skin conductance levels. Our results suggest that REM sleep may not only be associated with the consolidation of intrinsically sad material, but also enhances mood reactivity, at least on the short term.

  8. REM-Enriched Naps Are Associated with Memory Consolidation for Sad Stories and Enhance Mood-Related Reactivity

    Directory of Open Access Journals (Sweden)

    Médhi Gilson


    Full Text Available Emerging evidence suggests that emotion and affect modulate the relation between sleep and cognition. In the present study, we investigated the role of rapid-eye movement (REM sleep in mood regulation and memory consolidation for sad stories. In a counterbalanced design, participants (n = 24 listened to either a neutral or a sad story during two sessions, spaced one week apart. After listening to the story, half of the participants had a short (45 min morning nap. The other half had a long (90 min morning nap, richer in REM and N2 sleep. Story recall, mood evolution and changes in emotional response to the re-exposure to the story were assessed after the nap. Although recall performance was similar for sad and neutral stories irrespective of nap duration, sleep measures were correlated with recall performance in the sad story condition only. After the long nap, REM sleep density positively correlated with retrieval performance, while re-exposure to the sad story led to diminished mood and increased skin conductance levels. Our results suggest that REM sleep may not only be associated with the consolidation of intrinsically sad material, but also enhances mood reactivity, at least on the short term.

  9. Optimization of hydrothermal synthesis of pure phase zeolite Na-P1 from South African coal fly ashes. (United States)

    Musyoka, Nicholas M; Petrik, Leslie F; Gitari, Wilson M; Balfour, Gillian; Hums, Eric


    This study was aimed at optimizing the synthesis conditions for pure phase zeolite Na-P1 from three coal fly ashes obtained from power stations in the Mpumalanga province of South Africa. Synthesis variables evaluated were: hydrothermal treatment time (12-48 hours), temperature (100-160°C) and varying molar quantities of water during the hydrothermal treatment step (H(2)O:SiO(2) molar ratio ranged between 0-0.49). The optimum synthesis conditions for preparing pure phase zeolite Na-P1 were achieved when the molar regime was 1 SiO(2): 0.36 Al(2)O(3): 0.59 NaOH: 0.49 H(2)O and ageing was done at 47°C for 48 hours. The optimum hydrothermal treatment time and temperature was 48 hours and 140°C, respectively. Fly ashes sourced from two coal-fired power plants (A, B) were found to produce nearly same high purity zeolite Na-P1 under identical conditions whereas the third fly ash (C) lead to a low quality zeolite Na-P1 under these conditions. The cation exchange capacity for the high pure phase was found to be 4.11 meq/g. These results highlight the fact that adjustment of reactant composition and presynthesis or synthesis parameters, improved quality of zeolite Na-P1 can be achieved and hence an improved potential for application of zeolites prepared from coal fly ash.

  10. Functional characterization of a NapA Na(+)/H(+) antiporter from Thermus thermophilus. (United States)

    Furrer, Esther M; Ronchetti, Mirco F; Verrey, François; Pos, Klaas M


    Na(+)/H(+) antiporters are ubiquitous membrane proteins and play an important role in cell homeostasis. We amplified a gene encoding a member of the monovalent cation:proton antiporter-2 (CPA2) family (TC 2.A.37) from the Thermus thermophilus genome and expressed it in Escherichia coli. The gene product was identified as a member of the NapA subfamily and was found to be an active Na(+)(Li(+))/H(+) antiporter as it conferred resistance to the Na(+) and Li(+) sensitive strain E. coli EP432 (DeltanhaA, DeltanhaB) upon exposure to high concentration of these salts in the growth medium. Fluorescence measurements using the pH sensitive dye 9-amino-6-chloro-2-methoxyacridine in everted membrane vesicles of complemented E. coli EP432 showed high Li(+)/H(+) exchange activity at pH 6, but marginal Na(+)/H(+) antiport activity. Towards more alkaline conditions, Na(+)/H(+) exchange activity increased to a relative maximum at pH 8, where by contrast the Li(+)/H(+) exchange activity reached its relative minimum. Substitution of conserved residues D156 and D157 (located in the putative transmembrane helix 6) with Ala resulted in the complete loss of Na(+)/H(+) activity. Mutation of K305 (putative transmembrane helix 10) to Ala resulted in a compromised phenotype characterized by an increase in apparent K(m) for Na(+) (36 vs. 7.6 mM for the wildtype) and Li(+) (17 vs. 0.22 mM), In summary, the Na(+)/H(+) antiport activity profile of the NapA type transporter of T. thermophilus resembles that of NhaA from E. coli, whereas in contrast to NhaA the T. thermophilus NapA antiporter is characterized by high Li(+)/H(+) antiport activity at acidic pH.

  11. Nap environment control considering respiration rate and music tempo by using sensor agent robot (United States)

    Nakaso, Sayaka; Mita, Akira


    We propose a system that controls a nap environment considering respiration rates and music tempo by using a sensor agent robot. The proposed system consists of two sub-systems. The first sub-system measures respiration rates using optical flow. We conducted preparatory experiments to verify the accuracy of this sub-system. The experimental results showed that this sub-system can measure the respiration rates accurately despite several positional relationships. It was also shown that the accuracy could be affected by clothes, movements and light. The second sub-system we constructed was the music play sub-system that chooses music with the certain tempo corresponding to the respiration rates measured by the first sub-system. We conducted verification experiments to verify the effectiveness of this music play sub-system. The experimental results showed the effectiveness of varying music tempo based on the respiration rates in taking a nap. We also demonstrated this system in a real environment; a subject entered into the room being followed by ebioNα. When the subject was considered sleeping, ebioNα started measuring respiration rates, controlling music based on the respiration rates. As a result, we showed that this system could be realized. As a next step, we would like to improve this system to a nap environment control system to be used in offices. To realize this, we need to update the first sub-system measuring respiration rates by removing disturbances. We also need to upgrade music play sub-system considering the numbers of tunes, the kinds of music and time to change music.

  12. Effects of Pleurotus sapidus (Schulzer Sacc. treatment on nutrient composition and ruminal fermentability of barley straw, barley rootless, and a mixture of the two

    Directory of Open Access Journals (Sweden)

    Alfonso Soto-Sánchez


    Full Text Available Barley (Hordeum vulgare L., and its derivatives, ranks fourth in cereal production worldwide, and the Pleurotus species are among the most efficient types of lignocellulolytic white-rot fungi. The objective of this research study was to evaluate the degradation of barley straw and barley rootless with an inoculum of Pleurotus to improve their nutritional availability as a food source for ruminants. Two experiments were conducted; the first was to determine the effects of inoculation of Pleurotus sapidus (Schulzer Sacc. (PS in barley straw (BS, barley rootless (BR, and a 75% BS and 25% BR mixture (M. The second experiment was to evaluate the same substrates in vitro ruminal fermentation. Barley rootless had better organic matter (OM degradability than BS after 24 h incubation with PS. The protein content in BR was higher than in BS (P < 0.01. Enzyme activities had the highest concentration from the start of fermentation, and in vitro dry matter (DM degradability in BS and BR increased after 8 and 24 d fermentation, respectively (P < 0.05. Propionic acid concentration was enhanced after 16 d fermentation in BR (P < 0.5. The use of BS combined with BR exhibited better fermentation; this result provides relevant information for integrating BR with other substrates and improving the use of straw, which can be more nutritionally available for feeding ruminants.

  13. CM5, a Pre-Swarm Comprehensive Geomagnetic Field Model Derived from Over 12 Yr of CHAMP, Orsted, SAC-C and Observatory Data (United States)

    Sabaka, Terence J.; Olsen, Nils; Tyler, Robert H.; Kuvshinov, Alexey


    A comprehensive magnetic field model named CM5 has been derived from CHAMP, Ørsted and SAC-C satellite and observatory hourly-means data from 2000 August to 2013 January using the Swarm Level-2 Comprehensive Inversion (CI) algorithm. Swarm is a recently launched constellation of three satellites to map the Earth's magnetic field. The CI technique includes several interesting features such as the bias mitigation scheme known as Selective Infinite Variance Weighting (SIVW), a new treatment for attitude error in satellite vector measurements, and the inclusion of 3-D conductivity for ionospheric induction. SIVW has allowed for a much improved lithospheric field recovery over CM4 by exploiting CHAMP along-track difference data yielding resolution levels up to spherical harmonic degree 107, and has allowed for the successful extraction of the oceanic M2 tidal magnetic field from quiet, nightside data. The 3-D induction now captures anomalous Solar-quiet features in coastal observatory daily records. CM5 provides a satisfactory, continuous description of the major magnetic fields in the near-Earth region over this time span, and its lithospheric, ionospheric and oceanic M2 tidal constituents may be used as validation tools for future Swarm Level-2 products coming from the CI algorithm and other dedicated product algorithms.

  14. Stress Physiology and Virulence Characterization of Phomopsis asparagi (Sacc.) Bub6k isolated from Asparagus in Jiangxi Province of China

    Institute of Scientific and Technical Information of China (English)

    Yueping ZHANG; Guangyu CHEN; Shaochun LUO; Huaxiang QU; Yongping TANG; Qixin XIE; Jinsong ZHOU


    Abstract Fungal pathogen of asparagus stem blight was isolated. No significant ge- netic difference was detected among the three strains with 492 bp long ITS1-5.8S- ITS2 sequence. It was then identified through colony growth, conidia morphology, and molecular characterization. The physiological response to oxidation and osmosis stress, and virulence to Asparagus officinalis L. were analyzed. The results showed that the pathogen causing asparagus stem blight for A. officinalis L. in Jiangxi Province is Phomopsis asparagri (Sacc.) Bubok. Under pure culture conditions, the conidia were oval-shaped (a-type), with colorless single spore and single nucleus, containing 0-2 oil balls. Its vegetative growth rate was higher when cultured on 0.2 x potato dextrose agar (0.2 x PDA) medium than that on oatmeal agar (OA) medium. However, the pycnidia appeared earlier on OA medium than on 0.2 earlier PDA medium. The vegetative growth rate was depressed under oxidation (H202) or osmo- sis (NaCI) stress conditions, and totally inhibited under 7 mmol/L H202 or 2.4 mol/L NaCI. All the strains caused typical pathogenic symptoms to Asparagus officinalis L. at 7 days-post-inoculation (dpi) with conidia.

  15. Halotolerant cyanobacterium Aphanothece halophytica contains NapA-type Na+/H+ antiporters with novel ion specificity that are involved in salt tolerance at alkaline pH. (United States)

    Wutipraditkul, Nuchanat; Waditee, Rungaroon; Incharoensakdi, Aran; Hibino, Takashi; Tanaka, Yoshito; Nakamura, Tatsunosuke; Shikata, Masamitsu; Takabe, Tetsuko; Takabe, Teruhiro


    Aphanothece halophytica is a halotolerant alkaliphilic cyanobacterium which can grow at NaCl concentrations up to 3.0 M and at pH values up to 11. The genome sequence revealed that the cyanobacterium Synechocystis sp. strain PCC 6803 contains five putative Na+/H+ antiporters, two of which are homologous to NhaP of Pseudomonas aeruginosa and three of which are homologous to NapA of Enterococcus hirae. The physiological and functional properties of NapA-type antiporters are largely unknown. One of NapA-type antiporters in Synechocystis sp. strain PCC 6803 has been proposed to be essential for the survival of this organism. In this study, we examined the isolation and characterization of the homologous gene in Aphanothece halophytica. Two genes encoding polypeptides of the same size, designated Ap-napA1-1 and Ap-napA1-2, were isolated. Ap-NapA1-1 exhibited a higher level of homology to the Synechocystis ortholog (Syn-NapA1) than Ap-NapA1-2 exhibited. Ap-NapA1-1, Ap-NapA1-2, and Syn-NapA1 complemented the salt-sensitive phenotypes of an Escherichia coli mutant and exhibited strongly pH-dependent Na+/H+ and Li+/H+ exchange activities (the highest activities were at alkaline pH), although the activities of Ap-NapA1-2 were significantly lower than the activities of the other polypeptides. Only one these polypeptides, Ap-NapA1-2, complemented a K+ uptake-deficient E. coli mutant and exhibited K+ uptake activity. Mutagenesis experiments suggested the importance of Glu129, Asp225, and Asp226 in the putative transmembrane segment and Glu142 in the loop region for the activity. Overexpression of Ap-NapA1-1 in the freshwater cyanobacterium Synechococcus sp. strain PCC 7942 enhanced the salt tolerance of cells, especially at alkaline pH. These findings indicate that A. halophytica has two NapA1-type antiporters which exhibit different ion specificities and play an important role in salt tolerance at alkaline pH.

  16. Histone density is maintained during transcription mediated by the chromatin remodeler RSC and histone chaperone NAP1 in vitro. (United States)

    Kuryan, Benjamin G; Kim, Jessica; Tran, Nancy Nga H; Lombardo, Sarah R; Venkatesh, Swaminathan; Workman, Jerry L; Carey, Michael


    ATPases and histone chaperones facilitate RNA polymerase II (pol II) elongation on chromatin. In vivo, the coordinated action of these enzymes is necessary to permit pol II passage through a nucleosome while restoring histone density afterward. We have developed a biochemical system recapitulating this basic process. Transcription through a nucleosome in vitro requires the ATPase remodels structure of chromatin (RSC) and the histone chaperone nucleosome assembly protein 1 (NAP1). In the presence of NAP1, RSC generates a hexasome. Despite the propensity of RSC to evict histones, NAP1 reprograms the reaction such that the hexasome is retained on the template during multiple rounds of transcription. This work has implications toward understanding the mechanism of pol II elongation on chromatin.

  17. Synthesis and characterization of zeolite NaP using kaolin waste as a source of silicon and aluminum

    Energy Technology Data Exchange (ETDEWEB)

    Hildebrando, Edemarino Araujo, E-mail: [Universidae Federal do Para (UFPA), Maraba, PA (Brazil). Fac. de Engenharia de Materias. Lab. de Materiais Ceramicos; Andrade, Christiano Gianesi Bastos; Valenzuela-Diaz, Francisco Rolando [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Dept. de Metalurgia e Engenharia de Materiais; Rocha Junior, Carlos Augusto Ferreira da; Neves, Roberto de Freitas [Universidae Federal do Para (UFPA), Maraba, PA (Brazil). Int. de Tecnologia. Fac. de Engenharia Quimica; Angelica, Romulo Simoes [Universidae Federal do Para (UFPA), Maraba, PA (Brazil). Inst. de Geociencias. Fac. de Geologia


    The synthesis of zeolite NaP using kaolin waste, from the Amazon region, as a predominant source of silicon and aluminum has been studied. The zeolitisation process occurred in hydrothermal conditions using static autoclaving and the effects of time, temperature, and the Si/Al ratio were investigated. The starting material and the phases formed as reaction products were characterized by XRD, SEM and FTIR. The results showed that pure zeolite NaP is hydrothermally synthesized, at 100 °C for 20 hours, using meta kaolin waste material in alkaline medium in presence of additional silica. The XRD and SEM analyses indicate that the synthesized zeolite presents good crystallinity. (author)

  18. Napping during the night shift and recovery after work among hospital nurses

    Directory of Open Access Journals (Sweden)

    Thaís Aparecida de Castro Palermo


    Full Text Available OBJECTIVE: To analyze the association between the length of napping during the night shift and the recovery after work among nurses.METHOD: Cross-sectional epidemiological study involving 1940 nurses from 18 public hospitals in the City of Rio de Janeiro. A multidimensional and self-applied questionnaire was used with information about health, sociodemographic and occupational characteristics, health-related behaviors and housework. Multiple logistic regression was applied to identify the association, adjusted for confounding variables.RESULTS: The gross analyses showed 44%, 127% and 66% higher chances of a high level of recovery after work for nurses who sleep up to two hours, between 2.1 and 3 hours and 3.1 hours or more, respectively, when compared to the nurses who do not sleep. After adjusting for confounding variables, the association only continues significant for the group that sleeps 2.1 to 3 hours during the night shift (OR=1.79; 95%CI=1.33-2.41.CONCLUSION: The association between the length of napping and the high level of recovery after work, confirmed in the present results, can be included in the studies that aim to support more appropriate policies aimed at improving the workers' work, life and health conditions, not only in nursing, but night-shift workers in general.


    Directory of Open Access Journals (Sweden)

    Suciatmih Suciatmih


    Full Text Available Fusarium nivale (Fr. Ces., an endophytic fungi from Dendrobium crumenatum Sw. (pigeon orchidshowed an antimicroorganism activity against Absidia corymbifera (Cohn Sacc. & Trotter, causing of human zygomycosis. The aim of this study is to find out the effect of concentration of antimicroorganism agent, fermentation medium, and incubation time to control A. corymbifera by F. nivale; and to make curve of F. nivale growth and curve of its antimicrobial production. Five different concentrations of antimicroorganism agent (0, 75, 150, 225, and 300 ul, four different fermentation media (PotatoDextrose Yeast, Tauge Extract Broth , Kedelai Extract Broth , and Jagung Extract Broth, and eight different incubation times (0, 1, 2, 3, 4, 5, 6, and 7 days were chosen for this experiment. Parameters of the study were change of filtrate pH, dry weight of mycelial cell of F. nivale, and percentage inhibition of mycelial growth of A. corymbifera. The results indicated that antimicroorganism agent concentration of 150 ul applied and potato dextrose yeast medium were the most effective to inhibit A.corymbifera. The antimicroorganism agent was produced during growth of the fungi. The production of antimicroorganism agent coinced with the decrease in pH from 6.0 to 4.81; and the increase in pH from4,81 to 7.24-8.01. A optimum activity of antimicroorganism agent (31,23 during growth of fungi occurred on the 2th day of incubation. Keywords: A. corymbifera; aktivitas antimikroorganisme; F. nivale; persentase hambatan pertumbuhan miselium A. corymbifera

  20. Controlling Effects of Several Fungicides on Chlorophytum comosum Sclerotium roelfsii Sacc%几种杀菌剂对吊兰白绢病的防治效果

    Institute of Scientific and Technical Information of China (English)

    王丽; 王玲玲; 刘晓娇


    [Objective]The aim of this study was to screen better fungicides for controlling Chlorophytum comosum Sclerotium roelfsii Sacc. [ Method] With PVC potted Chlorophytum comosum as material, five kinds of fungicides on controlling Sclerotium roelfsii were observed by foliar spraying fungicides. [ Result ] The control effects of dimetachlone, difenoconazole, propiconazole and diniconazole for Sclerotium roelfsii are better than hymexazol. Among which, the control effect of diniconazole can reach 91. 90%. Difenoconazole controls Sclerotium roelfsii most rapidly, up to 83.10% after the first medication. [ Conclusion] The study provides theoretical basis for controlling Chlorophytum comosum Sclerotium roelfsii.%[目的]筛选出防治吊兰白绢病的有效杀菌剂.[方法]以PVC盆栽吊兰为材料,采用叶面喷药方式,进行了5种杀菌剂防治吊兰白绢病的药效试验.[结果]菌核净、世高、丙环唑和烯唑醇对吊兰白绢病的防治效果优于恶霉灵,其中烯唑醇的防治效果最佳,达到91.90%;世高对吊兰白绢病的防治效果最快,1次用药后防效可达83.10%.[结论]为吊兰白绢病的防治提供了理论依据.

  1. AWHONN Position Statement. The Role of Unlicensed Assistive Personnel (Nursing Assistive Personnel) in the Care of Women and Newborns. (United States)


    The Association of Women's Health, Obstetric and Neonatal Nurses (AWHONN) recognizes that unlicensed assistive personnel (UAP) also known as nursing assistive personnel (NAP) can function as supportive members of the health care team under the direction of the professional registered nurse (AWHONN, 2010). The professional registered nurse is ultimately responsible for the coordination and delivery of nursing care to women and newborns.

  2. The Role of Implied Motion in Engaging Audiences for Health Promotion: Encouraging Naps on a College Campus (United States)

    Mackert, Michael; Lazard, Allison; Guadagno, Marie; Hughes Wagner, Jessica


    Objective: Lack of sleep among college students negatively impacts health and academic outcomes. Building on research that implied motion imagery increases brain activity, this project tested visual design strategies to increase viewers' engagement with a health communication campaign promoting napping to improve sleep habits. Participants:…

  3. NAP1-Assisted Nucleosome Assembly on DNA Measured in Real Time by Single-Molecule Magnetic Tweezers

    NARCIS (Netherlands)

    Vlijm, R.; Smitshuijzen, J.S.J.; Lusser, A.; Dekker, C.


    While many proteins are involved in the assembly and (re)positioning of nucleosomes, the dynamics of protein-assisted nucleosome formation are not well understood. We study NAP1 (nucleosome assembly protein 1) assisted nucleosome formation at the single-molecule level using magnetic tweezers. This m

  4. Optimizing sleep/wake schedules in space: Sleep during chronic nocturnal sleep restriction with and without diurnal naps (United States)

    Mollicone, Daniel J.; Van Dongen, Hans P. A.; Dinges, David F.


    Effective sleep/wake schedules for space operations must balance severe time constraints with allocating sufficient time for sleep in order to sustain high levels of neurobehavioral performance. Developing such schedules requires knowledge about the relationship between scheduled "time in bed" (TIB) and actual physiological sleep obtained. A ground-based laboratory study in N=93 healthy adult subjects was conducted to investigate physiological sleep obtained in a range of restricted sleep schedules. Eighteen different conditions with restricted nocturnal anchor sleep, with and without diurnal naps, were examined in a response surface mapping paradigm. Sleep efficiency was found to be a function of total TIB per 24 h regardless of how the sleep was divided among nocturnal anchor sleep and diurnal nap sleep periods. The amounts of sleep stages 1+2 and REM showed more complex relationships with the durations of the anchor and nap sleep periods, while slow-wave sleep was essentially preserved among the different conditions of the experiment. The results of the study indicated that when sleep was chronically restricted, sleep duration was largely unaffected by whether the sleep was placed nocturnally or split between nocturnal anchor sleep periods and daytime naps. Having thus assessed that split-sleep schedules are feasible in terms of obtaining physiological sleep, further research will reveal whether these schedules and the associated variations in the distribution of sleep stages may be advantageous in mitigating neurobehavioral performance impairment in the face of limited time for sleep.

  5. Resonances in the sup 22 Na(p,. gamma. ) sup 23 Mg reaction

    Energy Technology Data Exchange (ETDEWEB)

    Seuthe, S.; Rolfs, C.; Schroeder, U.; Schulte, W.H.; Somorjai, E.; Trautvetter, H.P.; Waanders, F.B. (Muenster Univ. (Germany, F.R.). Inst. fuer Kernphysik); Kavanagh, R.W. (California Inst. of Tech., Pasadena (USA)); Ravn, H. (European Organization for Nuclear Research, Geneva (Switzerland)); Arnould, M.; Paulus, G. (Universite Libre de Bruxelles (Belgium). Inst. d' Astronomie et d' Astrophysique)


    The reaction {sup 22}Na(p, {gamma}){sup 23}Mg has been investigated in the energy range E{sub p}=0.17-1.2.9 MeV using a {sup 22}Na implanted target, a D{sub 2}O threshold detector, and NaI(Tl) and Ge detectors. Resonances in this reaction have been observed for the first time at E{sub p}=290, 457, 503, 613, 740 and 796 keV. The strengths of these resonances, and upper limits on the strengths for expected resonances in the energy range covered, are given. The stellar reaction rates deduced from the present work are about one order of magnitude than previous theoretical estimates; they are however significantly higher than the upper limits from one previous measurement. Some astrophysical consequences are discussed. (orig.).

  6. Crises convulsivas associadas à hipóxia neonatal e o potencial uso terapêutico do neuropeptídeo NAP = Hypoxia-associated neonatal seizures and potential therapeutic use of neuropeptide NAP

    Directory of Open Access Journals (Sweden)

    Greggio, Samuel


    Conclusões: apesar dos indícios positivos da aplicação do peptídeo NAP em modelos animais de neuropatologias e de seu sucesso preliminar em ensaios clínicos, são necessárias pesquisas adicionais a fim de entender particularidades desse composto, tais como mecanismo de ação e viabilidade clínica para o tratamento das crises convulsivas neonatais

  7. The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation. (United States)

    Bowman, Andrew; Ward, Richard; Wiechens, Nicola; Singh, Vijender; El-Mkami, Hassane; Norman, David George; Owen-Hughes, Tom


    Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant exchange. Currently, the best-characterized chaperone-histone interaction is that between the ubiquitous chaperone Asf1 and a dimer of H3 and H4. Nucleosome assembly proteins (Nap proteins) represent a distinct class of histone chaperone. Using pulsed electron double resonance (PELDOR) measurements and protein crosslinking, we show that two members of this class, Nap1 and Vps75, bind histones in the tetrameric conformation also observed when they are sequestered within the nucleosome. Furthermore, H3 and H4 trapped in their tetrameric state can be used as substrates in nucleosome assembly and chaperone-mediated lysine acetylation. This alternate mode of histone interaction provides a potential means of maintaining the integrity of the histone tetramer during cycles of nucleosome reassembly.

  8. Growth of Campylobacter jejuni on nitrate and nitrite: electron transport to NapA and NrfA via NrfH and distinct roles for NrfA and the globin Cgb in protection against nitrosative stress. (United States)

    Pittman, Marc S; Elvers, Karen T; Lee, Lucy; Jones, Michael A; Poole, Robert K; Park, Simon F; Kelly, David J


    Pathways of electron transport to periplasmic nitrate (NapA) and nitrite (NrfA) reductases have been investigated in Campylobacter jejuni, a microaerophilic food-borne pathogen. The nap operon is unusual in lacking napC (encoding a tetra-haem c-type cytochrome) and napF, but contains a novel gene of unknown function, napL. The iron-sulphur protein NapG has a major role in electron transfer to the NapAB complex, but we show that slow nitrate-dependent growth of a napG mutant can be sustained by electron transfer from NrfH, the electron donor to the nitrite reductase NrfA. A napL mutant possessed approximately 50% lower NapA activity than the wild type but showed normal growth with nitrate as the electron acceptor. NrfA was constitutive and was shown to play a role in protection against nitrosative stress in addition to the previously identified NO-inducible single domain globin, Cgb. However, nitrite also induced cgb expression in an NssR-dependent manner, suggesting that growth of C. jejuni with nitrite causes nitrosative stress. This was confirmed by lack of growth of cgb and nssR mutants, and slow growth of the nrfA mutant, in media containing nitrite. Thus, NrfA and Cgb together provide C. jejuni with constitutive and inducible components of a robust defence against nitrosative stress.

  9. Identification of genomic differences between Campylobacter jejuni subsp. jejuni and C. jejuni subsp. doylei at the nap locus leads to the development of a C. jejuni subspeciation multiplex PCR method

    Directory of Open Access Journals (Sweden)

    Heath Sekou


    Full Text Available Abstract Background The human bacterial pathogen Campylobacter jejuni contains two subspecies: C. jejuni subsp. jejuni (Cjj and C. jejuni subsp. doylei (Cjd. Although Cjd strains are isolated infrequently in many parts of the world, they are obtained primarily from human clinical samples and result in an unusual clinical symptomatology in that, in addition to gastroenteritis, they are associated often with bacteremia. In this study, we describe a novel multiplex PCR method, based on the nitrate reductase (nap locus, that can be used to unambiguously subspeciate C. jejuni isolates. Results Internal and flanking napA and napB primer sets were designed, based on existing C. jejuni and Campylobacter coli genome sequences to create two multiplex PCR primer sets, nap mpx1 and nap mpx2. Genomic DNA from 161 C. jejuni subsp. jejuni (Cjj and 27 C. jejuni subsp. doylei (Cjd strains were amplified with these multiplex primer sets. The Cjd strains could be distinguished clearly from the Cjj strains using either nap mpx1 or mpx2. In addition, combination of either nap multiplex method with an existing lpxA speciation multiplex method resulted in the unambiguous and simultaneous speciation and subspeciation of the thermophilic Campylobacters. The Cjd nap amplicons were also sequenced: all Cjd strains tested contained identical 2761 bp deletions in napA and several Cjd strains contained deletions in napB. Conclusion The nap multiplex PCR primer sets are robust and give a 100% discrimination of C. jejuni subspecies. The ability to rapidly subspeciate C. jejuni as well as speciate thermophilic Campylobacter species, most of which are pathogenic in humans, in a single amplification will be of value to clinical laboratories in strain identification and the determination of the environmental source of campylobacterioses caused by Cjd. Finally, the sequences of the Cjd napA and napB loci suggest that Cjd strains arose from a common ancestor, providing clues as to

  10. REM-Enriched Naps Are Associated with Memory Consolidation for Sad Stories and Enhance Mood-Related Reactivity


    Médhi Gilson; Gaétane Deliens; Rachel Leproult; Alice Bodart; Antoine Nonclercq; Rudy Ercek; Philippe Peigneux


    Emerging evidence suggests that emotion and affect modulate the relation between sleep and cognition. In the present study, we investigated the role of rapid-eye movement (REM) sleep in mood regulation and memory consolidation for sad stories. In a counterbalanced design, participants (n = 24) listened to either a neutral or a sad story during two sessions, spaced one week apart. After listening to the story, half of the participants had a short (45 min) morning nap. The other half had a long...

  11. Synthesis of Zeolites Na-P1 from South African Coal Fly Ash: Effect of Impeller Design and Agitation

    Directory of Open Access Journals (Sweden)

    Leslie Petrik


    Full Text Available South African fly ash has been shown to be a useful feedstock for the synthesis of some zeolites. The present study focuses on the effect of impeller design and agitation rates on the synthesis of zeolite Na-P1 which are critical to the commercialization of this product. The effects of three impeller designs (4-flat blade, Anchor and Archimedes screw impellers and three agitation speeds (150, 200 and 300 rpm were investigated using a modified previously reported synthesis conditions; 48 hours of ageing at 47 °C and static hydrothermal treatment at 140 °C for 48 hours. The experimental results demonstrated that the phase purity of zeolite Na-P1 was strongly affected by the agitation rate and the type of impeller used during the ageing step of the synthesis process. Although zeolite Na-P1 was synthesized with a space time yield (STY of 15 ± 0.4 kg d−1m−3and a product yield of 0.98±0.05 g zeolites/g fly ash for each impeller at different agitation speeds, zeolite formation was assessed to be fairly unsuccessful in some cases due the occurrence of undissolved mullite and/or the formation of impurities such as hydroxysodalite with the zeolitic product. This study also showed that a high crystalline zeolite Na-P1 can be synthesized from South African coal fly ash using a 4-flat blade impeller at an agitation rate of 200 rpm during the ageing step at 47 °C for 48 hours followed by static hydrothermal treatment at 140 °C for 48 hours.

  12. 9种杀菌剂对花生白绢病菌的室内毒力测定%Toxicity Determination of 9 Fungicides on Sclerotium rolfsii Sacc.

    Institute of Scientific and Technical Information of China (English)

    谢瑾卉; 朱茂山


    Absrtact:In order to select safety and effective fungicides to Sclerotium rolfsii Sacc.,9 kinds of fungicides to the pathogenic fun-gus of Sclerotium rolfsii Sacc.were tested by means of mycelium growth rate method respectively.The results showed that Sclero-tium rolfsii Sacc.was inhibited under the condition of the 9 kinds of fungicides.Among the 9 fungicides ,the inhibition efficiency of 10% hexaconazole EC was the strongest,with the EC50 of 0.0989 μg /ml ,the inhibition efficiency of 50% fludioxonil WP, 25% difenoconazole EC,25% pyraclostrobin EC,reduced in succession,with the EC50 of 0.1223 ,1 .3823,1 .5371 μg /ml.The inhibition efficiency of 50% cyprodinil WG was the weakest,with the EC50 of 84.7805 μg /ml.%为筛选出安全有效的花生白绢病防治药剂。在室内离体条件下采用菌丝生长速率法测定9种杀菌剂对花生白绢病菌的毒力活性。9种杀菌剂对花生白绢病菌表现出不同的毒力活性。10%已唑醇 EC 毒力最强, EC50为0.0989μg /ml;50%咯菌腈 WP 、25%苯醚甲环唑 EC、25%吡唑醚菌酯 EC 毒力作用较强,EC50分别为0.1223、1.3823、1.5371μg /ml;50%嘧菌环胺 WG 毒力最弱,EC50为84.7805μg /ml。

  13. Visual field information in Nap-of-the-Earth flight by teleoperated Helmet-Mounted displays (United States)

    Grunwald, Arthur J.; Kohn, S.; Merhav, S. J.


    The human ability to derive Control-Oriented Visual Field Information from teleoperated Helmet-Mounted displays in Nap-of-the-Earth flight, is investigated. The visual field with these types of displays originates from a Forward Looking Infrared Radiation Camera, gimbal-mounted at the front of the aircraft and slaved to the pilot's line-of-sight, to obtain wide-angle visual coverage. Although these displays are proved to be effective in Apache and Cobra helicopter night operations, they demand very high pilot proficiency and work load. Experimental work presented in the paper has shown that part of the difficulties encountered in vehicular control by means of these displays can be attributed to the narrow viewing aperture and head/camera slaving system phase lags. Both these shortcomings will impair visuo-vestibular coordination, when voluntary head rotation is present. This might result in errors in estimating the Control-Oriented Visual Field Information vital in vehicular control, such as the vehicle yaw rate or the anticipated flight path, or might even lead to visuo-vestibular conflicts (motion sickness). Since, under these conditions, the pilot will tend to minimize head rotation, the full wide-angle coverage of the Helmet-Mounted Display, provided by the line-of-sight slaving system, is not always fully utilized.

  14. Perspectivas del uso de bacterias rizosféricas en el control de Pyricularia grisea (Cooke Sacc. en el cultivo del arroz (Oryza sativa L.

    Directory of Open Access Journals (Sweden)

    Yanelis Acebo Guerrero


    Full Text Available Prospect of the use of bacteria in the control Pyricularia grisea (Cooke Sacc. on rice (Oriza sativa L. Título corto: Bacterias rizosféricas para controlar la piriculariosis ResumenEl arroz es fuente de alimento para una gran parte de la población mundial, con alto promedio de consumo anual. En este cultivo las enfermedades de origen microbiano constituyen uno de los factores que inciden en la obtención de bajos rendimientos y calidad de los granos. La piriculariosis o añublo del arroz, causada por Pyricularia grisea, es la enfermedad más importante en este cultivo en América Latina, ya que puede provocar hasta el 100% de reducción de los rendimientos. Como parte de la estrategia de agricultura sostenible, se trata de controlar estos patógenos y lograr altos rendimientos del cultivo mediante una combinación adecuada de fertilizantes químicos y productos biológicos. En este sentido, la aplicación de inoculantes bacterianos constituidos por bacterias promotoras del crecimiento vegetal (Plant Growth- Promoting Bacteria, PGPB, por sus siglas en inglés ha constituido una alternativa ecológica que favorece la conservación del medioambiente y el ecosistema. Este trabajo tiene como objetivo abordar el estado actual y las perspectivas de uso de bacterias rizosféricas en el control de Pyricularia grisea en el cultivo del arroz, tratando algunos temas relevantes, como son las principales enfermedades que afectan al cultivo, los géneros de PGPB más utilizados para el control de las mismas y sus principales mecanismos de acción. Palabras clave: bacterias rizosféricas, arroz, piriculariosis. AbstractRice is an important food supply for a large part of the world population and its consumption rates are very high. Microbial diseases are one of the main causes that provoke low yields and low-quality spotted grains. Although fungi, bacteria and viruses are mostly the responsible for these losses, fungal diseases strike more frequently

  15. Development and application of a microplate method to evaluate the efficacy of essential oils against Penicillium italicum Wehmer, Penicillium digitatum Sacc. and Colletotrichum musea (Berk. & M.A. Curtis Arx, three postharvest fungal pathogens of fruits

    Directory of Open Access Journals (Sweden)

    Bajji, M.


    Full Text Available A microbioassay was developed for evaluating the in vitro antifungal activity of 30 preselected essential oils. A template based on 10 serial dilutions with eight replicates per dilution arranged on two 96-well ELISA plates was used as a reproducible and standardized design to identify the in vitro effectiveness of these essential oils against Penicillium italicum Wehmer, Penicillium digitatum Sacc. and Colletotrichum musea (Berk. & M.A. Curtis Arx, three postharvest fungal pathogens, on fruits. Growth of mycelium was monitored by measuring optical density (492 nm. Cinnamomum zeylanicum, Cinnamomum verum and Eugenia caryophyllus were found to be still active against all the three pathogens even at 100 ppm. Compared to other methods, this microbioassay proved to be a rapid, reproducible, and efficient method for testing the efficacy of essential oils that inhibit spore germination in P. italicum, P. digitatum and C. musea. The assay requires relatively small amounts of essential oils.

  16. 1株拮抗酵母菌对柑橘绿霉病菌的抑制作用%Inhibitive activity of Kluyveromyces marxianus on Penicillium digitatum Sacc.

    Institute of Scientific and Technical Information of China (English)

    罗建军; 耿鹏; 胡美英; 黄慧斯; 贾建文


    以柑橘绿霉病菌(Penicillium digitatum Sacc.)为供试材料,研究拮抗酵母菌(Kluyverom yces marxianus)对柑橘采后绿霉病菌的抑制效果,并观察其对采后柑橘果实多酚氧化酶(PPO)、过氧化物酶(POD)和苯丙氨酸解氨酶(PAL)活性的影响.结果表明:拮抗酵母菌的菌株悬浮液和培养原液对柑橘采后绿霉病菌均有较好的抑制作用,但菌株培养上清液和热杀死液对柑橘绿霉病菌的抑制效果较差;与对照相比,接种拮抗菌与病原菌能够诱导柑橘果实PPO、POD和PAL活性的升高;拮抗酵母菌对柑橘绿霉病菌的抑菌机制与营养和空间的竞争以及诱导抗病性相关酶有关.%The inhibitive activity of Kluyveromyces marxianus against citrus green mold caused by Penicillium digitatum Sacc. was investigated, as well as its effect on the activities of polyphenol oxi-dase (PPO), peroxidase (POD) and phenylalanine ammonium-lyase (PAL). The results showed that the treatments of washed cell suspension and living cell suspension have better inhibiting effect, as compared to the control treatment; while the culture filtrate and autoclaved cell suspensions could exacerbate green mold decay. The application of K. marxianus could induce higher PPO, POD and PAL activity as compared to the control. It was suggested that the biocontrol mechanism might be competitive for nutrition and space, and contribute to the secretion of antagonistc substance.

  17. Proteomic analysis of a NAP1 Clostridium difficile clinical isolate resistant to metronidazole.

    Directory of Open Access Journals (Sweden)

    Patrick M Chong

    Full Text Available BACKGROUND: Clostridium difficile is an anaerobic, Gram-positive bacterium that has been implicated as the leading cause of antibiotic-associated diarrhea. Metronidazole is currently the first-line treatment for mild to moderate C. difficile infections. Our laboratory isolated a strain of C. difficile with a stable resistance phenotype to metronidazole. A shotgun proteomics approach was used to compare differences in the proteomes of metronidazole-resistant and -susceptible isolates. METHODOLOGY/PRINCIPAL FINDINGS: NAP1 C. difficile strains CD26A54_R (Met-resistant, CD26A54_S (reduced- susceptibility, and VLOO13 (Met-susceptible were grown to mid-log phase, and spiked with metronidazole at concentrations 2 doubling dilutions below the MIC. Peptides from each sample were labeled with iTRAQ and subjected to 2D-LC-MS/MS analysis. In the absence of metronidazole, higher expression was observed of some proteins in C. difficile strains CD26A54_S and CD26A54_R that may be involved with reduced susceptibility or resistance to metronidazole, including DNA repair proteins, putative nitroreductases, and the ferric uptake regulator (Fur. After treatment with metronidazole, moderate increases were seen in the expression of stress-related proteins in all strains. A moderate increase was also observed in the expression of the DNA repair protein RecA in CD26A54_R. CONCLUSIONS/SIGNIFICANCE: This study provided an in-depth proteomic analysis of a stable, metronidazole-resistant C. difficile isolate. The results suggested that a multi-factorial response may be associated with high level metronidazole-resistance in C. difficile, including the possible roles of altered iron metabolism and/or DNA repair.

  18. A visual ERP study of impulse inhibition following a zaleplon-induced nap after sleep deprivation.

    Directory of Open Access Journals (Sweden)

    Qianru Zhang

    Full Text Available The side effects of a zaleplon-induced nap as a countermeasure in the reduction of impulse inhibition function decline following 30 h of sleep deprivation (SD were examined by event-related brain potentials. Sixteen adult participants performed a Go/NoGo task at five time points: (1 baseline; (2 after 30 h of SD; (3 upon sudden awakening, also called 2 h post-drug; (4 4 h post-drug; and (5 6 h post-drug. Behavior results show an increase in both reaction time and false alarm rates after SD and sudden awakening, and a marked decrease at 4 h and 6 h post-drug in zaleplon and placebo conditions. However, no difference was observed between the zaleplon condition and the placebo condition. In event-related potential (ERP reults compared with results obtained under control conditions, NoGo-P3 latencies significantly increased, whereas the Nogo-P3 amplitude decreased after 30 h of SD and sudden awakening in both the zaleplon condition and the placebo condition. These results indicate that SD attenuates resource allocation and error monitoring for NoGo stimuli. In addition, NoGo-P3 latencies were longer in the zaleplon condition compared with the placebo condition at sudden awakening. Additionally, the NoGo-P3 latencies were shorter in the zaleplon condition than in the placebo condition at 4 h and 6 h post-drug. These results indicate that zaleplon at a dose of 10 mg/day may help subjects achieve a better recovery or maintain better impulse inhibition function, although the side effects of zaleplon last at least 2 h post-drug.

  19. Long-Term Single and Joint Effects of Excessive Daytime Napping on the HOMA-IR Index and Glycosylated Hemoglobin: A Prospective Cohort Study. (United States)

    Li, Xue; Pang, Xiuyu; Zhang, Qiao; Qu, Qiannuo; Hou, Zhigang; Liu, Zhipeng; Lv, Lin; Na, Guanqiong; Zhang, Wei; Sun, Changhao; Li, Ying


    This prospective cohort study was conducted to assess the duration of daytime napping and its effect combined with night sleep deprivation on the risk of developing high HOMA-IR (homeostasis model assessment of insulin resistance) index and disadvantageous changes in glycosylated hemoglobin (HbA1c) levels.A total of 5845 diabetes-free subjects (2736 women and 3109 men), 30 to 65 years of age, were targeted for this cohort study since 2008. Multiple adjusted Cox regression models were performed to evaluate the single and joint effects of daytime napping on the risk of an elevated HbA1c level and high HOMA-IR index.After an average of 4.5 years of follow-up, >30 minutes of daytime napping was significantly associated with an increased risk of an elevated HbA1c level (>6.5%) in men and women (all P trend 30 minutes napping and the combination of no sleep deprivation with >30 minutes daytime napping were all associated with an HbA1c level >6.5% (HR = 2.08, 95% CI = 1.24-3.51; HR = 4.00, 95% CI = 2.03-7.90; and HR = 2.05, 95% CI = 1.29-3.27, respectively). No sleep deprivation combined with >30 minutes daytime napping correlated with a high risk of an HbA1c level between 5.7% and 6.4% and high HOMA-IR index (HR = 2.12, 95% CI = 1.48-3.02; and HR = 1.35, 95% CI = 1.10-1.65, respectively).Daytime napping >30 minutes was associated with a high risk of an elevated HbA1c level and high HOMA-IR index. No sleep deprivation combined with napping >30 minutes carries a risk of abnormal glucose metabolism. Sleep deprivation combined with brief daytime napping <30 minutes was not associated with a risk for an elevated HbA1c level and high HOMA-IR index.

  20. A single administration of the peptide NAP induces long-term protective changes against the consequences of head injury: gene Atlas array analysis. (United States)

    Romano, Jacob; Beni-Adani, Liana; Nissenbaum, Orlev Levy; Brenneman, Douglas E; Shohami, Esther; Gozes, Illana


    The femtomolar-acting eight-amino-acid peptide (NAP), derived from activity-dependent neuroprotective protein (ADNP), provides long-term protection against the deleterious effects of closed head injury (CHI) in mice. Fifteen minutes after injury, mice were divided into two groups, control and NAP-treated and a single subcutaneous injection of NAP or vehicle was administered. A third group served as sham-treated (not subjected to head trauma). Each mouse was assessed for its clinical function, using neurological severity score, at various time intervals following CHI, up to 30-45 d. Total cerebral cortex RNA was prepared from the site of injury of CHI mice, and from parallel regions in peptide-treated and sham brains. RNA was then reversed transcribed to yield radioactive cDNA preparations that were hybridized to Atlas array membranes containing 1200 cDNAs spots. Comparison of sham-treated individual mice showed differential expression levels of at least 15 mRNA species. Furthermore, results indicated that one of the genes that did not change among individuals but specifically increased after CHI and decreased after NAP treatment was the cell surface glycoprotein Mac-1 (CD11B antigen). Thus, Mac-1 is suggested as a marker for the long-term outcome of head injury and as a potential target for NAP protective actions.

  1. 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors. (United States)

    Pandit, J J; Andrade, J; Bogod, D G; Hitchman, J M; Jonker, W R; Lucas, N; Mackay, J H; Nimmo, A F; O'Connor, K; O'Sullivan, E P; Paul, R G; Palmer, J H M G; Plaat, F; Radcliffe, J J; Sury, M R J; Torevell, H E; Wang, M; Hainsworth, J; Cook, T M


    We present the main findings of the 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia (AAGA). Incidences were estimated using reports of accidental awareness as the numerator, and a parallel national anaesthetic activity survey to provide denominator data. The incidence of certain/probable and possible accidental awareness cases was ~1:19,600 anaesthetics (95% confidence interval 1:16,700-23,450). However, there was considerable variation across subtypes of techniques or subspecialities. The incidence with neuromuscular block (NMB) was ~1:8200 (1:7030-9700), and without, it was ~1:135,900 (1:78,600-299,000). The cases of AAGA reported to NAP5 were overwhelmingly cases of unintended awareness during NMB. The incidence of accidental awareness during Caesarean section was ~1:670 (1:380-1300). Two-thirds (82, 66%) of cases of accidental awareness experiences arose in the dynamic phases of anaesthesia, namely induction of and emergence from anaesthesia. During induction of anaesthesia, contributory factors included: use of thiopental, rapid sequence induction, obesity, difficult airway management, NMB, and interruptions of anaesthetic delivery during movement from anaesthetic room to theatre. During emergence from anaesthesia, residual paralysis was perceived by patients as accidental awareness, and commonly related to a failure to ensure full return of motor capacity. One-third (43, 33%) of accidental awareness events arose during the maintenance phase of anaesthesia, mostly due to problems at induction or towards the end of anaesthesia. Factors increasing the risk of accidental awareness included: female sex, age (younger adults, but not children), obesity, anaesthetist seniority (junior trainees), previous awareness, out-of-hours operating, emergencies, type of surgery (obstetric, cardiac, thoracic), and use of NMB. The following factors were not risk factors for accidental awareness: ASA physical status, race, and use or omission

  2. A model for the human's use of visual field cues in nap-of-the-Earth flight (United States)

    Hess, R. A.; Chan, K.


    A simple model is developed which describes the manner in which the human pilot may use visual field cues in controlling a vehicle in nap-of-the earth flight. The model is based upon the feedforward of information obtained from streamer patterns in the visual field to the inner-most loop of a multi-loop pilot/vehicle model. In this framework, the model is a logical extension of pursuit and preview models of the human operator which have appeared in the literature. Simulation and flight test data involving low-level helicopter flight tasks are applied to model development and validation.

  3. Cloning, Sequence Identification and Expression Analysis of NAP1L5 in Porcine Placenta at Different Gestation Stages%猪NAP1L5基因克隆、序列鉴定及在不同妊娠时期胎盘中的差异表达分析

    Institute of Scientific and Technical Information of China (English)

    顾婷; 赵书红; 李长春


    旨在获得猪NAP1L5基因的序列特征、组织表达及生物学功能等相关信息.本试验通过RT-PCR克隆了猪NAP1L5基因,并运用生物信息学方法分析了不同物种序列进化关系,运用荧光定量PCR技术检测了NAP1L5在梅山猪不同妊娠时期胎盘中的表达.序列分析结果表明,猪NAP1 L5基因CDS全长579 bp,编码193个氨基酸.其核苷酸序列与牛的相似性为89%,其中氨基酸序列包含一段保守的核小体组装蛋白(Nucleosome assembly protein,NAP)特征序列.荧光定量结果表明NAP1L5基因随着妊娠时期的增长呈上升表达,在26和50 d之间表达量差异极显著(P<0.01).以上结果支持了NAP1L5基因可能与猪胎儿营养获取及早期发育有关,为进一步研究猪NAP1 L5基因的功能奠定了基础.%The aim of this study was to obtain the information about sequence structure, tissue expression and biology function of porcine NAP1L5 gene. In the present study* the porcine NAP1L5 was cloned by RT-PCR, the sequence was analyzed by bioinformatics method, and its relative mRNA expression was detected by quantitative RT-PCR in porcine placenta at different gestation stages. Sequence analysis showed that the CDS region of the porcine NAP1L5 gene included 579 nucleotides, encoding 193 amino acids, and the sequence similarity of NAP1L5 between the pig and cattle was 89%. The amino acids sequence included the nucleosome assembly protein. The result of quantitative RT-PCR indicated that the expression of porcine NAP1L5 increased with the placenta development and there were significant difference between d26 and d50 of gestation stage (P<0. 01). These results suggest that NAP1L5 is probably related to the nutrition absorption and early development of porcine fetus, and make a foundation for the further study on the function of NAP1L5 gene in porcine.

  4. NapA Na(+)/H(+) Antiporter as a Sodium Extrusion System Supplementary to the Vacuolar Na(+)-ATPase in Enterococcus hirae. (United States)

    Kawano, M; Igarashi, K; Solioz, M; Kakinuma, Y


    Enterococcus hirae has two sodium extrusion systems: the NapA Na(+)/H(+) antiporter and the vacuolar Na(+)-ATPase. We found that a NapA mutant, WD4, which is deficient in Na(+)/H(+) antiporter activity, grew well in the pH range of 6 to 10 up to 200 mM sodium. This was due to active, potential-independent sodium extrusion by the Na(+)-ATPase, which was induced under these conditions. The NapA Na(+)/H(+) antiporter is thus not a prerequisite for growth of E. hirae in the presence of sodium, but plays a supplementary role in sodium extrusion at acidic pH.

  5. Hiina tänapäeva arhitektuur - karmiilmeline, aga põnev / Zhang Ke, Zhang Hong, Xiaodu Liu ; interv. Hanna Läkk ja Ene Läkk

    Index Scriptorium Estoniae

    Zhang Ke


    Intervjuu Hiina arhitektuuribüroo Standardarchitecture arhitektide Zhang Ke ja Zhang Hongiga ning arhitektuuribüroo Urbanus arhitekti Xiaodu Liuga Hollandis Hiina tänapäeva tutvustaval näitusel. Hiina arhitektide haridusest, oma arhitektuuribüroode töödest, tänapäeva hiina arhitektuurist, põhiprobleemidest

  6. New insights into alkylammonium-functionalized clinoptilolite and Na-P1 zeolite: Structural and textural features (United States)

    Muir, Barbara; Matusik, Jakub; Bajda, Tomasz


    The area of zeolites' application could be expanded by utilizing their surfaces. Zeolites are frequently modified to increase their hydrophobicity and to generate the negative charge of the surface. The main objective of the study was to investigate and compare the features of natural clinoptilolite and synthetic zeolite Na-P1 modified by selected surfactants involving quaternary ammonium salts. The FTIR study indicates that with increasing carbon chain length in the surfactant attached to the zeolites surface the molecules adopt a more disordered structure. FTIR was also used to determine the efficiency of surface modification. Thermal analysis revealed that the presence of surfactant results in additional exothermic effects associated with the breaking of electrostatic bonds between zeolites and surfactants. The mass losses are in line with ECEC and CHN data. The textural study indicates that the synthetic zeolite Na-P1 has better sorption properties than natural clinoptilolite. The modification process always reduces the SBET and porosity of the material. With an increasing carbon chain length of surfactants all the texture parameters decrease.

  7. Biallelic expression of Tssc4, Nap1l4, Phlda2 and Osbpl5 in adult cattle

    Indian Academy of Sciences (India)

    Mengnan Wang; Dongjie Li; Mingyue Zhang; Wenzhi Yang; Guojiang Wu; Yali Cui; Shijie Li


    Genomic imprinting of the Cdkn1c/Kcnq1ot1 region shows lack of conservation between human and mouse. This region has been reported to be associated with Beckwith–Wiedemann syndrome (BWS) and cancer. To increase our understanding of imprinted genes in bovine Cdkn1c/Kcnq1ot1 imprinting cluster, we assessed the imprinting status of four cattle genes (Tssc4, Nap1l4, Phlda2 and Osbpl5) in seven types of tissues: heart, liver, spleen, lung, kidney, skeletal muscle and subcutaneous fat using polymorphism-based sequencing approach. It was found that all the four genes showed biallelic expression in tissues in which transcripts were detected. Nap1l4 and Tssc4 were detected in all examined tissues, while the expression of Phlda2 and Osbpl5 was tissue-specific. Phlda2 was not detected in heart and subcutaneous fat, and Osbpl5 was not detected in spleen and skeletal muscle. In addition, identification of species-specific imprinted genes is necessary to understand the evolution of genomic imprinting and to elucidate mechanisms leading to allele-specific expression.

  8. Regulovatelný zdroj napájený a řízený pomocí USB


    PAVLÍČEK, Petr


    Diplomová práce se zabývá návrhem a realizací napěťového zdroje, který je napájený a řízený pomocí sběrnice USB. V teoretické části je popsán princip komunikace na sběrnici USB a popsány ovladače, které tuto komunikaci zajišťují, jsou popsány principy funkce lineárních stabilizátorů a základních typů DC/DC měničů. Uvedena je zde také teorie PID regulátorů. Praktická část práce se zabývá návrhem vhodné topologie DC/DC měniče, návrhem způsobu jeho řízení a vytvořením algoritmů k tomu určených. ...

  9. Integrated synthesis of zeolites 4A and Na-P1 using coal fly ash for application in the formulation of detergents and swine wastewater treatment. (United States)

    Cardoso, Ariela M; Horn, Martha B; Ferret, Lizete S; Azevedo, Carla M N; Pires, Marçal


    Several researchers have reported zeolite synthesis using coal ash for a wide range of applications. However, little attention has been given to green processes, including moderate synthesis conditions, using waste as raw material and effluent reuse or reduction. In this study, Brazilian coal fly ashes were used for integrated synthesis of zeolites 4A and Na-P1 by two different routes and under moderate operating conditions (temperature and pressure). Both procedures produced zeolites with similar conversions (zeolite 4A at 82% purity and zeolite Na-P1 at 57-61%) and high CEC values (zeolites 4A: 4.5meqCa(2+)g(-1) and zeolites Na-P1: 2.6-2.8meqNH4(+)g(-1)). However, process 1 generated less effluent for the zeolite mass produced (7mLg(-1)), with low residual Si and Al levels and 74% of the Si available in the coal fly ash incorporated into the zeolite, while only 55% is used in process 2. For use as a builder in detergents, synthetic zeolite 4A exhibited conformity parameters equal to or greater than those of the commercial zeolite adopted as reference. Treatment of swine wastewater with zeolite Na-P1 resulted in a high removal capacity for total ammoniacal nitrogen (31mgg(-1)).

  10. H14[NaP5W29MoO110]: a Novel and Useful Catalyst for Aminolysis of Epoxides with Amines under Solvent-Free Conditions

    Institute of Scientific and Technical Information of China (English)

    HERAVI,Majid M; BEHBAHANI,Farahnaz K; OSKOOIE,Hossien A; BAMOHARRAM,Fatemeh F


    A simple and efficient method has been developed for the synthesis of β-amino alcohols by ring opening of ep-oxides in the presence of a catalytic amount of H14[NaP5W29MoO110] at room temperature under solvent-free condi-tions. The reaction works well for both aromatic and aliphatic amines.

  11. Cloning and characterization of the NapA acid phosphatase/phosphotransferase of Morganella morganii: identification of a new family of bacterial acid-phosphatase-encoding genes. (United States)

    Thaller, M C; Lombardi, G; Berlutti, F; Schippa, S; Rossolini, G M


    The gene encoding a minor phosphate-irrepressible acid phosphatase (named NapA) of Morganella morganii was cloned and sequenced, and its product characterized. NapA is a secreted acid phosphatase composed of four 27 kDa polypeptide subunits. The enzyme is active on several organic phosphate monoesters but not on diesters, and is also endowed with transphosphorylating activity from organic phosphoric acid esters to nucleosides and other compounds with free hydroxyl groups. Its activity is inhibited by EDTA, inorganic phosphate, nucleosides and Ca2+, but not by fluoride or tartrate, and is enhanced by Mg2+, Co2+ and Zn2+. At the sequence level, the NapA enzyme did not show similarities to any other sequenced bacterial phosphatases. However, a search for homologous genes in sequence databases allowed identification of two open reading frames located within sequenced regions of the Escherichia coli and Proteus mirabilis genomes respectively, encoding proteins of unknown function which are highly homologous to the Morganella enzyme. Moreover, the properties of the NapA enzyme are very similar to those reported for the periplasmic nonspecific acid phosphatase II of Salmonella typhimurium (for which no sequence data are available). These data point to the existence of a new family of bacterial acid phosphatases, which we propose designating class B bacterial acid phosphatases.

  12. A Truncated Arabidopsis NUCLEOSOME ASSEMBLY PROTEIN 1,AtNAP1;3T,Alters Plant Growth Responses to Abscisic Acid and Salt in the Atnap 1;3-2 Mutant

    Institute of Scientific and Technical Information of China (English)

    Zi-Qiang Liu; Juan Gao; Ai-Wu Dong


    Chromatin remodeling is thought to have crucial roles in plant adaptive response to environmental stimulus.Here,we report that,in Arebidopsis,the evolutionarily conserved histone chaperone,NUCLEOSOME ASSEMBLY PROTEIN 1 (NAP1),is involved in plant response to abscisic acid (ABA),a phytohormone important in stress adaptation.We show that simultaneous loss-of-function of AtNAP1;1,AtNAP1;2,and AtNAP1;3 (the triple mutant m123-1) caused a slight hypersensitive response to ABA in seedling growth.Strikingly,the other triple mutant m123-2 containing a different mutant allele of AtNAP1;3,the Atnap1;3-2 allele,showed a hyposensitive response to ABA and a decreased tolerance to salt stress.This ABAhyposensitive and salt response phenotype specifically associated with the Atnap1;3-2 mutant allele.We show that this mutant allele produced a truncated protein,AtNAP1;3T,which lacks 34 amino acids at the C-terminus compared to the wild-type protein AtNAP1;3.We further show that the heterozygous plants containing the Atnap1;3-2 mutant allele as well as transgenic plants overexpressing AtNAP1;3T exhibit ABA-hyposensitive phenotype.It thus indicates that AtNAP1;3T functions as a dominant negative factor in ABA response.The expression of some ABA-responsive genes,including genes encoding protein kinases and transcription regulators,was found perturbed in the mutant and in the AtNAP1;3T transgenic plants.Taken together,our study uncovered AtNAP1 proteins as positive regulators and AtNAP1;3T as a negative regulator in ABA signaling pathways,providing a novel link of chromatin remodeling to hormonal and stress responses.

  13. Association Between Insomnia Symptoms, Daytime Napping, And Falls In Community-dwelling Elderly [associação Entre Sintomas De Insônia, Cochilo Diurno E Quedas Em Idosos Da Comunidade


    Pereira A.A.; Ceolim M.F.; Neri A.L.


    This study focused on associations between insomnia symptoms, daytime napping, and falls in community-dwelling elderly, using a population- based cross-sectional design and probability sample with 689 community-dwelling elders. The protocol consisted of self-reported and physical performance variables. The study used univariate and multivariate logistic regression analysis with statistical significance set at p < 0.05. Prevalence rates for insomnia symptoms and daytime napping were 49.9% (n =...

  14. Rapid spread of Clostridium difficile NAP1/027/ST1 in Chile confirms the emergence of the epidemic strain in Latin America. (United States)

    Aguayo, C; Flores, R; Lévesque, S; Araya, P; Ulloa, S; Lagos, J; Hormazabal, J C; Tognarelli, J; Ibáñez, D; Pidal, P; Duery, O; Olivares, B; Fernández, J


    Clostridium difficile infection has gained importance in recent years as a result of the rapid spread of epidemic strains, including hypervirulent strains. This study reports the molecular epidemiology of C. difficile obtained from hospitalized patients in Chile. Seven hundred and nineteen isolates of toxigenic C. difficile from 45 hospitals across the country were characterized through toxin profile, pulsed-field gel electrophoresis (PFGE), and sequencing of the tcdC gene. In addition, polymerase chain reaction (PCR) ribotyping and multilocus sequence typing (MLST) were performed on a subset of selected strains. PFGE typing of 719 isolates of C. difficile produced 60 PFGE patterns (subtypes). Subtype 1 was predominant (79% of isolates) and related to the hypervirulent strain (NAP1). Subtype 1 showed 73% relatedness with nine other subtypes, which had a similar tcdC deletion. Subtype 1 corresponded to ribotype 027 and ST1. This report shows the wide dissemination of the hypervirulent strain NAP1/027/ST1 in Chile.

  15. The neutrophil-activating Dps protein of Helicobacter pylori, HP-NAP, adopts a mechanism different from Escherichia coli Dps to bind and condense DNA. (United States)

    Ceci, Pierpaolo; Mangiarotti, Laura; Rivetti, Claudio; Chiancone, Emilia


    The Helicobacter pylori neutrophil-activating protein (HP-NAP), a member of the Dps family, is a fundamental virulence factor involved in H.pylori-associated disease. Dps proteins protect bacterial DNA from oxidizing radicals generated by the Fenton reaction and also from various other damaging agents. DNA protection has a chemical component based on the highly conserved ferroxidase activity of Dps proteins, and a physical one based on the capacity of those Dps proteins that contain a positively charged N-terminus to bind and condense DNA. HP-NAP does not possess a positively charged N-terminus but, unlike the other members of the family, is characterized by a positively charged protein surface. To establish whether this distinctive property could be exploited to bind DNA, gel shift, fluorescence quenching and atomic force microscopy (AFM) experiments were performed over the pH range 6.5-8.5. HP-NAP does not self-aggregate in contrast to Escherichia coli Dps, but is able to bind and even condense DNA at slightly acid pH values. The DNA condensation capacity acts in concert with the ferritin-like activity and could be used to advantage by H.pylori to survive during host-infection and other stress challenges. A model for DNA binding/condensation is proposed that accounts for all the experimental observations.

  16. Up-expression of NapA and other oxidative stress proteins is a compensatory response to loss of major Helicobacter pylori stress resistance factors. (United States)

    Olczak, Adriana A; Wang, Ge; Maier, Robert J


    Twenty-six Helicobacter pylori targeted mutant strains with deficiencies in oxidative stress combating proteins, including 12 double mutant strains were analyzed via physiological and proteomic approaches to distinguish the major expression changes caused by the mutations. Mutations were introduced into both a Mtz(S) and a Mtz(R) strain background. Most of the mutations caused increased growth sensitivity of the strains to oxygen, and they all exhibited clear compensatory up-expression of oxidative stress resistance proteins enabling survival of the bacterium. The most frequent up-expressed oxidative stress resistance factor (observed in 16 of the mutants) was the iron-sequestering protein NapA, linking iron sequestration with oxidative stress resistance. The up-expression of individual proteins in mutants ranged from 2 to 10 fold that of the wild type strain, even when incubated in a low O(2) environment. For example, a considerably higher level of catalase expression (4 fold of that in the wild-type strain) was observed in ahpC napA and ahpC sodB double mutants. A Fur mutant up-expressed ferritin (Pfr) protein 20-fold. In some mutant strains the bacterial DNA is protected from oxidative stress damage apparently via overexpression of oxidative stress-combating proteins such as NapA, catalase or MdaB (an NADPH quinone reductase). Our results show that H. pylori has a variety of ways to compensate for loss of major oxidative stress combating factors.

  17. Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization. (United States)

    Emelyanov, Alexander V; Rabbani, Joshua; Mehta, Monika; Vershilova, Elena; Keogh, Michael C; Fyodorov, Dmitry V


    Nuclear DNA in the male gamete of sexually reproducing animals is organized as sperm chromatin compacted primarily by sperm-specific protamines. Fertilization leads to sperm chromatin remodeling, during which protamines are expelled and replaced by histones. Despite our increased understanding of the factors that mediate nucleosome assembly in the nascent male pronucleus, the machinery for protamine removal remains largely unknown. Here we identify four Drosophila protamine chaperones that mediate the dissociation of protamine-DNA complexes: NAP-1, NLP, and nucleophosmin are previously characterized histone chaperones, and TAP/p32 has no known function in chromatin metabolism. We show that TAP/p32 is required for the removal of Drosophila protamine B in vitro, whereas NAP-1, NLP, and Nph share roles in the removal of protamine A. Embryos from P32-null females show defective formation of the male pronucleus in vivo. TAP/p32, similar to NAP-1, NLP, and Nph, facilitates nucleosome assembly in vitro and is therefore a histone chaperone. Furthermore, mutants of P32, Nlp, and Nph exhibit synthetic-lethal genetic interactions. In summary, we identified factors mediating protamine removal from DNA and reconstituted in a defined system the process of sperm chromatin remodeling that exchanges protamines for histones to form the nucleosome-based chromatin characteristic of somatic cells.

  18. A Recombinant DNA Plasmid Encoding the sIL-4R-NAP Fusion Protein Suppress Airway Inflammation in an OVA-Induced Mouse Model of Asthma. (United States)

    Liu, Xin; Fu, Guo; Ji, Zhenyu; Huang, Xiabing; Ding, Cong; Jiang, Hui; Wang, Xiaolong; Du, Mingxuan; Wang, Ting; Kang, Qiaozhen


    Asthma is a chronic inflammatory airway disease. It was prevalently perceived that Th2 cells played the crucial role in asthma pathogenesis, which has been identified as the important target for anti-asthma therapy. The soluble IL-4 receptor (sIL-4R), which is the decoy receptor for Th2 cytokine IL-4, has been reported to be effective in treating asthma in phase I/II clinical trail. To develop more efficacious anti-asthma agent, we attempt to test whether the Helicobacter pylori neutrophil-activating protein (HP-NAP), a novel TLR2 agonist, would enhance the efficacy of sIL-4R in anti-asthma therapy. In our work, we constructed a pcDNA3.1-sIL-4R-NAP plasmid, named PSN, encoding fusion protein of murine sIL-4R and HP-NAP. PSN significantly inhibited airway inflammation, decreased the serum OVA-specific IgE levels and remodeled the Th1/Th2 balance. Notably, PSN is more effective on anti-asthma therapy comparing with plasmid only expressing sIL-4R.

  19. Purification and characterization of a novel alginate lyase from the marine bacterium Cobetia sp. NAP1 isolated from brown algae. (United States)

    Yagi, Hisashi; Fujise, Asako; Itabashi, Narumi; Ohshiro, Takashi


    The application of marine resources, instead of fossil fuels, for biomass production is important for building a sustainable society. Seaweed is valuable as a source of marine biomass for producing biofuels such as ethanol, and can be used in various fields. Alginate is an anionic polysaccharide that forms the main component of brown algae. Various alginate lyases (e.g. exo- and endo-types and oligoalginate lyase) are generally used to degrade alginate. We herein describe a novel alginate lyase, AlgC-PL7, which belongs to the polysaccharide lyase 7 family. AlgC-PL7 was isolated from the halophilic Gram-negative bacterium Cobetia sp. NAP1 collected from the brown algae Padina arborescens Holmes. The optimal temperature and pH for AlgC-PL7 activity were 45 °C and 8, respectively. Additionally, AlgC-PL7 was thermostable and salt-tolerant, exhibited broad substrate specificity, and degraded alginate into monosaccharides. Therefore, AlgC-PL7 is a promising enzyme for the production of biofuels.

  20. Investigation of thermonuclear $^{18}$Ne($\\alpha$,$p$)$^{21}$Na rate via resonant elastic scattering of $^{21}$Na+$p$

    CERN Document Server

    Zhang, L Y; Parikh, A; Xu, S W; Yamaguchi, H; Kahl, D; Kubono, S; Mohr, P; Hu, J; Ma, P; Chen, S Z; Wakabayashi, Y; Wang, H W; Tian, W D; Chen, R F; Guo, B; Hashimoto, T; Togano, Y; Hayakawa, S; Teranishi, T; Iwasa, N; Yamada, T; Komatsubara, T; Zhang, Y H; Zhou, X H


    The $^{18}$Ne($\\alpha$,$p$)$^{21}$Na reaction is thought to be one of the key breakout reactions from the hot CNO cycles to the rp-process in type I x-ray bursts. In this work, the resonant properties of the compound nucleus $^{22}$Mg have been investigated by measuring the resonant elastic scattering of $^{21}$Na+$p$. An 89 MeV $^{21}$Na radioactive beam delivered from the CNS Radioactive Ion Beam Separator bombarded an 8.8 mg/cm$^2$ thick polyethylene (CH$_{2}$)$_{n}$ target. The $^{21}$Na beam intensity was about 2$\\times$10$^{5}$ pps, with a purity of about 70% on target. The recoiled protons were measured at the center-of-mass scattering angles of $\\theta_{c.m.}$$\\approx$175.2${^\\circ}$, 152.2${^\\circ}$, and 150.5${^\\circ}$ by three sets of $\\Delta E$-$E$ telescopes, respectively. The excitation function was obtained with the thick-target method over energies $E_x$($^{22}$Mg)=5.5--9.2 MeV. In total, 23 states above the proton-threshold in $^{22}$Mg were observed, and their resonant parameters were determ...

  1. Sleep duration, daytime napping, markers of obstructive sleep apnea and stroke in a population of southern China (United States)

    Wen, Ye; Pi, Fu-Hua; Guo, Pi; Dong, Wen-Ya; Xie, Yu-Qing; Wang, Xiang-Yu; Xia, Fang-Fang; Pang, Shao-Jie; Wu, Yan-Chun; Wang, Yuan-Yuan; Zhang, Qing-Ying


    Sleep habits are associated with stroke in western populations, but this relation has been rarely investigated in China. Moreover, the differences among stroke subtypes remain unclear. This study aimed to explore the associations of total stroke, including ischemic and hemorrhagic type, with sleep habits of a population in southern China. We performed a case-control study in patients admitted to the hospital with first stroke and community control subjects. A total of 333 patients (n = 223, 67.0%, with ischemic stroke; n = 110, 23.0%, with hemorrhagic stroke) and 547 controls were enrolled in the study. Participants completed a structured questionnaire to identify sleep habits and other stroke risk factors. Least absolute shrinkage and selection operator (Lasso) and multiple logistic regression were performed to identify risk factors of disease. Incidence of stroke, and its subtypes, was significantly associated with snorting/gasping, snoring, sleep duration, and daytime napping. Snorting/gasping was identified as an important risk factor in the Lasso logistic regression model (Lasso’ β = 0.84), and the result was proven to be robust. This study showed the association between stroke and sleep habits in the southern Chinese population and might help in better detecting important sleep-related factors for stroke risk. PMID:27698374

  2. Sleep and Alertness Management III: Effects of a Nap and Hypnotics on Performance During the Late Evening, Night and Early Morning in Marmosets (United States)


    hypnotics on performance during the late evening, night and early morning in marmosets Date November 2006 Author(s) Dr. post-nap hangovers. In this study, the marmoset monkey model was validated as a model for testing the effects of drugs on performance during...evening, night and early morning missions was tested. It was proven that the homeostasis in marmoset monkeys after sleep deprivation is similar to the

  3. Identification of nucleosome assembly protein 1 (NAP1) as an interacting partner of plant ribosomal protein S6 (RPS6) and a positive regulator of rDNA transcription

    Energy Technology Data Exchange (ETDEWEB)

    Son, Ora [Department of Biological Science, Sookmyung Women' s University, Seoul 140-742 (Korea, Republic of); Kim, Sunghan [Department of Biological Science, Sookmyung Women' s University, Seoul 140-742 (Korea, Republic of); Department of Plant Science, Plant Genomics and Breeding Institute, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 151-921 (Korea, Republic of); Shin, Yun-jeong [Department of Biological Science, Sookmyung Women' s University, Seoul 140-742 (Korea, Republic of); Kim, Woo-Young [College of Pharmacy, Sookmyung Women' s University, Seoul 140-742 (Korea, Republic of); Koh, Hee-Jong, E-mail: [Department of Plant Science, Plant Genomics and Breeding Institute, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 151-921 (Korea, Republic of); Cheon, Choong-Ill, E-mail: [Department of Biological Science, Sookmyung Women' s University, Seoul 140-742 (Korea, Republic of)


    The ribosomal protein S6 (RPS6) is a downstream component of the signaling mediated by the target of rapamycin (TOR) kinase that acts as a central regulator of the key metabolic processes, such as protein translation and ribosome biogenesis, in response to various environmental cues. In our previous study, we identified a novel role of plant RPS6, which negatively regulates rDNA transcription, forming a complex with a plant-specific histone deacetylase, AtHD2B. Here we report that the Arabidopsis RPS6 interacts additionally with a histone chaperone, nucleosome assembly protein 1(AtNAP1;1). The interaction does not appear to preclude the association of RPS6 with AtHD2B, as the AtNAP1 was also able to interact with AtHD2B as well as with an RPS6-AtHD2B fusion protein in the BiFC assay and pulldown experiment. Similar to a positive effect of the ribosomal S6 kinase 1 (AtS6K1) on rDNA transcription observed in this study, overexpression or down regulation of the AtNAP1;1 resulted in concomitant increase and decrease, respectively, in rDNA transcription suggesting a positive regulatory role played by AtNAP1 in plant rDNA transcription, possibly through derepression of the negative effect of the RPS6-AtHD2B complex. - Highlights: • Nucleosome assembly protein 1 (AtNAP1) interacts with RPS6 as well as with AtHD2B. • rDNA transcription is regulated S6K1. • Overexpression or down regulation of AtNAP1 results in concomitant increase or decrease in rDNA transcription.

  4. Critical Care (United States)

    Critical care helps people with life-threatening injuries and illnesses. It might treat problems such as complications ... a team of specially-trained health care providers. Critical care usually takes place in an intensive care ...

  5. Tracheostomy care (United States)

    Respiratory failure - tracheostomy care; Ventilator - tracheostomy care; Respiratory insufficiency - tracheostomy care ... Before you leave the hospital, health care providers will teach you how ... and suction the tube Keep the air you breathe moist Clean ...

  6. Kollektiivne töö, rohujuuredemokraatia ja opositsioonikultuuri visuaalsed vormid tänapäeva Eestis = Collective work, grassroots democracy and visual forms of opposition culture in contemporary Estonia / Airi Triisberg

    Index Scriptorium Estoniae

    Triisberg, Airi, 1982-


    Kokkupuutepunktidest sotsiaalsete liikumiste ja kaasaegse kunsti vahel tänapäeva Eestis, keskendudes kollektiivse ja sekkuva iseloomuga praktikatele avalikus ruumis. Prussakovi nimelise jalgrattaühingu Vabaduse väljaku aktsioonist Tallinnas, Linnalabori katuseaia jt. projektidest, "vabaduse plakati" aktsioonist, Johnson&Johnson "Paldiski projektist" jm.

  7. Hospice Care (United States)

    Hospice care is end-of-life care. A team of health care professionals and volunteers provides it. ... can remain as alert and comfortable as possible. Hospice programs also provide services to support a patient's ...

  8. Palliative Care (United States)

    Palliative care is treatment of the discomfort, symptoms, and stress of serious illness. It provides relief from distressing symptoms ... of the medical treatments you're receiving. Hospice care, care at the end of life, always includes ...

  9. Palliative Care (United States)

    ... you are a partner with the palliative care team as you all work toward the same goal — providing the best quality of life for your child for as ... Care for Children With Terminal Illness Managing Home Health Care Taking Care of You: Support ...

  10. Hospice care (United States)

    ... family a break (called respite care). Doctor services. Nursing care. Home health aide and homemaker services. Counseling. Medical ... may be given in other locations, including: A nursing home A ... in charge of care is called the primary care giver. This may ...

  11. Synthesis of Ibuprofen Using Silica-Supported Preyssler Nanoparticles (H14[NaP5W30O110]/SiO2 as an Eco-Friendly, Inexpensive, and Efficient Catalyst

    Directory of Open Access Journals (Sweden)

    Ali Gharib


    Full Text Available This paper describes an alternative and simple procedure for the synthesis of Ibuprofen using Silica-Supported Preyssler Nanoparticles (H14[NaP5W30O110]/SiO2 (SPNPs, as an eco-friendly, inexpensive, and efficient catalyst. High yields, simplicity of operation, and easy work-up procedure are some advantages of this protocol. Silica-Supported Preyssler Nanoparticles (H14[NaP5W30O110]/SiO2 (SPNPs offer the advantages of a higher hydrolytic and thermal stability. The salient features of Preyssler’s anion are availability, nontoxicity and reusability. We believe this methodology can find usefulness in organic synthesis.

  12. Preparation of NaP Zeolite with Low Si/Al Molar Ratio from Flying Ash%利用粉煤灰合成低硅铝比NaP分子筛

    Institute of Scientific and Technical Information of China (English)

    陈彦广; 解骢浩; 韩洪晶; 赵法军; 王宝辉


    以粉煤灰分级处理获得的硅铝组分Na2 SiO3和NaAlO2为原料,通过水热反应制备了NaP型分子筛.考察了钠盐不同阴离子和有机空间位阻剂对NaP分子筛制备的影响,优化了水热合成NaP分子筛的工艺参数,采用X射线衍射( XRD)、扫描电子显微镜( SEM)和BET方程对NaP分子筛产品的晶型、形貌和孔容进行分析表征,对NaP分子筛吸附水溶液中Ni2+的性能进行了评价.结果表明,合成NaP分子筛的最佳原料摩尔比为n(Na2O):n(SiO2):n(Al2O3):n(H2O)=3.23:1.95:1:226,反应温度为120℃,晶化时间为8 h.当钠盐中阴离子为Br-时,可增大 P型分子筛产率并提高其纯度.添加有机空间位阻剂三乙醇胺( TEA )[n(TEA):n(Al2O3)=1:1]时,合成的P型分子筛粒径较小且具有较大的孔容,此时对应的Ni2+去除率较高,可达96.2%.%Taking Na2 SiO3 and NaAlO2 obtained from flying ash by staged treatment as raw material, NaP zeo-lite was prepared via hydrothermal method. The influences of organic steric agents and sodium salts with differ-ent anions on the preparation of NaP zeolite were investigated. The synthetic parameters of the hydrothermal system for NaP zeolite were optimized. The crystal form, morphology and pore volume of the NaP zeolite were characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM) and Brunauer-Emmett-Teller ( BET ) surface analysis, respectively. The adsorption performance of the NaP zeolite in Ni2+-containing solution was evaluated. The results show that the optimal parameters for the preparation NaP zeolite are as following:n(Na2O) : n(SiO2) : n(Al2O3) : n(H2O)= 1.66:1:0.51:116, the reaction temperature is 120 ℃, crystalization time is 8 h. Br- is in favor of improving the purity and increasing the yield of NaP zeolite. With the addition of triethylolamine( TEA) , the grain size of NaP zeolite becomes smaller and the pore volume is enlarged. The maximum removal rate for Ni2+ is about 96.2%.

  13. Pin care (United States)

    ... gov/pubmed/24302374 . Nagy K. Discharge instructions for wound cares. The American Association of the Surgery of Trauma. . Accessed May 13, 2016.

  14. Palliative Care (United States)

    ... possessions to others, write a letter or a poem or compose a song, or decide what they ... One Year Off Treatment Transitioning to Adult Care Long-Term Follow-Up Care Coping With Cancer Overview ...

  15. Sedimentological interpretation and stratigraphical position of glacigenic deposits in the Napęków area (Holy Cross Mountains, Poland

    Directory of Open Access Journals (Sweden)

    Ludwikowska-Kędzia Małgorzata


    Full Text Available The identification of depositional conditions and stratigraphical position of glacigenic deposits in the Napęków area is important for the genetic and stratigraphical interpretation of Quaternary deposits in the central part of the Holy Cross Mountains, as well as for a revision of the course and extent of Middle Polish (Saalian glaciations. These deposits comprise a series of diamictons which occur between sandy-gravelly deposits. Based on results of macro- and microscopic sedimentological investigations, analysis of heavy mineral composition, roundness and frosting of quartz grains, as well as OSL dating, this complex must have formed during the Odranian Glaciation (Drenthe, Saalian, MIS 6. Sandy-gravelly deposits are of fluvioglacial and melt-out origin. Diamictons represent subglacial traction till. Their facies diversity is a result of variations in time and space, complex processes of deposition and deformation, responsible for their formation at the base of the active ice sheet. This glacigenic depositional complex was transformed by erosion-denudation and aeolian processes in a periglacial environment during the Vistulian (Weichselian, MIS 5d-2.

  16. Sedimentological interpretation and stratigraphical position of glacigenic deposits in the Napęków area (Holy Cross Mountains, Poland) (United States)

    Ludwikowska-Kędzia, Małgorzata; Pawelec, Halina; Adamiec, Grzegorz


    The identification of depositional conditions and stratigraphical position of glacigenic deposits in the Napęków area is important for the genetic and stratigraphical interpretation of Quaternary deposits in the central part of the Holy Cross Mountains, as well as for a revision of the course and extent of Middle Polish (Saalian) glaciations. These deposits comprise a series of diamictons which occur between sandy-gravelly deposits. Based on results of macro- and microscopic sedimentological investigations, analysis of heavy mineral composition, roundness and frosting of quartz grains, as well as OSL dating, this complex must have formed during the Odranian Glaciation (Drenthe, Saalian, MIS 6). Sandy-gravelly deposits are of fluvioglacial and melt-out origin. Diamictons represent subglacial traction till. Their facies diversity is a result of variations in time and space, complex processes of deposition and deformation, responsible for their formation at the base of the active ice sheet. This glacigenic depositional complex was transformed by erosion-denudation and aeolian processes in a periglacial environment during the Vistulian (Weichselian, MIS 5d-2).

  17. Comparing Care

    NARCIS (Netherlands)

    Evert Pommer; Isolde Woittiez; John Stevens


    Home care is one of the most important means of compensating for disabilities and ensuring continuity in people's daily functioning. Home care services in the Netherlands have recently been transferred from a national social security provision for long-term care to a local social service. In most ot

  18. Preconception Care and Prenatal Care (United States)

    ... at risk for complications? How does stress affect pregnancy? NICHD Research Information Clinical Trials Resources and Publications Preconception Care and Prenatal Care: Condition Information Skip sharing on social media links Share this: Page Content What is preconception ...

  19. Virtual care

    DEFF Research Database (Denmark)

    Kamp, Annette; Aaløkke Ballegaard, Stinne

    of retrenchment, promising better quality, empowerment of citizens and work that is smarter and more qualified. Through ethnographic field studies we study the introduction of virtual home care in Danish elderly care, focusing on the implications for relational work and care relations. Virtual home care entails...... and professionals, and they instigate change in organization and professional identities. Studies, which more specifically deal with telecare, stress how virtualization alters the character of the observations care workers are able to make, and how the validity of the patients’ own measurements and observations...... point out how issues of trust and surveillance, which are always negotiated in care relations, are in fact accentuated in this kind of virtual care work. Moreover, we stress that the contemporary institutional context, organization and time schedules have a vast impact on the practices developed....

  20. Who Cares for Care Leavers? (United States)

    Askew, Julie; Rodgers, Paul; West, Andrew


    This chapter describes a programme of learning and development at the University of Sheffield, United Kingdom, to support looked-after children and care leavers (youth previously provided care outside or beyond family) throughout the student lifecycle. In this context, looked-after children are those cared for by a town/city authority where…

  1. Advance care directives (United States)

    ... advance directive; Do-not-resuscitate - advance directive; Durable power of attorney - advance care directive; POA - advance care directive; Health care agent - advance care directive; Health care proxy - ...

  2. A national survey (NAP5-Ireland baseline) to estimate an annual incidence of accidental awareness during general anaesthesia in Ireland.

    LENUS (Irish Health Repository)

    Jonker, W R


    As part of the 5th National Audit Project of the Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland concerning accidental awareness during general anaesthesia, we issued a questionnaire to every consultant anaesthetist in each of 46 public hospitals in Ireland, represented by 41 local co-ordinators. The survey ascertained the number of new cases of accidental awareness becoming known to them for patients under their care or supervision for a calendar year, as well as their career experience. Consultants from all hospitals responded, with an individual response rate of 87% (299 anaesthetists). There were eight new cases of accidental awareness that became known to consultants in 2011; an estimated incidence of 1:23 366. Two out of the eight cases (25%) occurred at or after induction of anaesthesia, but before surgery; four cases (50%) occurred during surgery; and two cases (25%) occurred after surgery was complete, but before full emergence. Four cases were associated with pain or distress (50%), one after an experience at induction and three after experiences during surgery. There were no formal complaints or legal actions that arose in 2011 related to awareness. Depth of anaesthesia monitoring was reported to be available in 33 (80%) departments, and was used by 184 consultants (62%), 18 (6%) routinely. None of the 46 hospitals had a policy to prevent or manage awareness. Similar to the results of a larger survey in the UK, the disparity between the incidence of awareness as known to anaesthetists and that reported in trials warrants explanation. Compared with UK practice, there appears to be greater use of depth of anaesthesia monitoring in Ireland, although this is still infrequent.

  3. Entrevista e análise do discurso de um usuário de um NAPS: Sandro e a injustiça institucionalizada

    Directory of Open Access Journals (Sweden)

    Sérgio Bacchi Machado


    Full Text Available No presente artigo analisou-se a transcrição de uma entrevista com um usuário de um Núcleo de Atenção Psicossocial (NAPS do Estado de São Paulo segundo o método de análise institucional de discurso. Visou-se, com isso, ao estudo da constituição do sujeito no discurso - o que implica tanto o seu vínculo com a instituição quanto a interlocução que se configura com o entrevistador no ato mesmo da entrevista. Empreendendo uma analítica do discurso do usuário - em detrimento de classificações psiquiátricas ou psicopatológicas impostas aos sujeitos -, realizou-se o delineamento de sua singularidade por meio da positivação de seu discurso. Buscou-se, ainda, mapear as correlações de força presentes em diversos temas recorrentes em sua fala, tais como a injustiça, a violência, os médicos, a sexualidade, medicamentos e cotidiano institucional. Por fim, propôs-se uma abordagem que, longe de corroborar com uma concepção da verdade como ente subterrâneo aguardando ser descoberto pelo pesquisador, toma o par usuário/instituição como uma produção única e indissociável.

  4. 基于条件概率的短时睡眠状态实时估计%Sleep level estimation based on conditional probability for nap

    Institute of Scientific and Technical Information of China (English)

    王蓓; 张俊民; 张涛; 王行愚


    目的:根据脑电信号的特征,提出基于条件概率的睡眠状态实时估计方法,为睡眠监测提供反映睡眠状态连续变化的客观评价依据。方法在白天短时睡眠过程中,同步采集了4导与睡眠相关的脑电信号( C3-A2,C4-A1,O1-A2,O2-A1),对每5秒记录数据进行傅里叶变换,分别计算了8~13 Hz和2~7 Hz 的脑电节律能量占空比特征参数。主要方法包含了学习和测试两个阶段:在学习阶段,根据训练数据获得脑电特征参数的概率密度分布;在测试阶段,根据当前特征,得到各睡眠分期的条件概率,并计算获得睡眠状态的估计值。结果分析和测试了12名受试者的短时睡眠数据。通过与睡眠分期的人工判读结果相比较,睡眠状态估计值呈现了睡眠深度的连续变化。觉醒期的显著性差异为2.94,睡眠一期和二期分别为1.78和1.62,分析结果符合实际规律。结论本文所定义的睡眠状态估计值蕴含了睡眠分期的特征,较好地反映了睡眠阶段在持续和过渡期间的连续变化过程,能够为白天短时睡眠状态分析提供实时监测和分析的客观评价依据。%Objective According to the characteristics of electroencephalograph( EEG),an automatic sleep level estimation method based on conditional probability is developed. The ultimate purpose is to obtain and realize the real-time sleep level evaluation. Methods There are 4 EEG channels(O2 -A1 ,O1 -A2 ,C4 -A1 , C3 -A2 )recorded during nap. For every 5-second data,two characteristic parameters of ratio of EEG rhythms (8-13 Hz,2-7 Hz)are calculated after fast Fourier transformation(FFT). The main method consists of two models:learning and testing. During the learning stage,the probability density functions of EEG parameters are obtained based on the training data. During the testing stage,the sleep level is estimated based on the conditional probability of sleep stages. Results The

  5. CARES Foundation (United States)

    ... today and CARES will receive 5% of your purchase! THEIR HISTORY: In 2001, Lauren’s Hope introduced the ... Go to the staff directory Find Us on Facebook Recent Tweets In case you missed it! http:// ...

  6. Dysarthria - care (United States)

    Speech and language disorder - dysarthria care; Slurred speech - dysarthria; Articulation disorder - dysarthria ... Dysarthria is a condition that occurs when there are problems with the muscles that help you talk. ...

  7. Residential Care (United States)

    ... Last name: Email: * Zip: * *required We will not sell or share your name. Residential Care Tweet Bookmark ... for the future. Use Alzheimer's Navigator ™ - our free online tool - to guide you as you map out ...

  8. The 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors. (United States)

    Pandit, J J; Andrade, J; Bogod, D G; Hitchman, J M; Jonker, W R; Lucas, N; Mackay, J H; Nimmo, A F; O'Connor, K; O'Sullivan, E P; Paul, R G; Palmer, J H MacG; Plaat, F; Radcliffe, J J; Sury, M R J; Torevell, H E; Wang, M; Hainsworth, J; Cook, T M


    not risk factors for accidental awareness: ASA physical status; race; and use or omission of nitrous oxide. We recommend that an anaesthetic checklist, to be an integral part of the World Health Organization Safer Surgery checklist, is introduced as an aid to preventing accidental awareness. This paper is a shortened version describing the main findings from 5th National Audit Project - the full report can be found at

  9. Caring Encounters (United States)

    Gunn, Alyson


    Children with autism may seem to not care about things or have the same range of emotions as those of us who see them and care for them. But they do have empathy and they can be taught how to communicate it, says the author, a teacher of children with autism. We simply need to listen to them, watch them, and be with them in their moment.

  10. 幼儿在园午睡存在的问题及对策研究%Research on the Problems in Children's Nap in Kinder-garten and the Countermeasures

    Institute of Scientific and Technical Information of China (English)



    午睡是幼儿在幼儿园生活中的一个重要环节,对幼儿身心发展有着十分重要的作用,有利于良好生活习惯的养成和下午的学习活动。然而,幼儿在园午睡却存在着很多问题。因此要提高幼儿园、教师和家长对幼儿午睡重要性的认识,合理调整幼儿在园午睡时间,创设良好的午睡环境,促进幼儿良好午睡习惯的养成,使其身心健康发展。%The nap is an important part of children's kindergarten life, for it plays an important role in children's physical and psy-chological development and the development of their good living habit, but there exist many problems in children's nap. This pa-per mainly proposes countermeasures for the exiting problems.

  11. Integrating Palliative Care into Primary Care. (United States)

    Gorman, Rosemary D


    Improved quality of life, care consistent with patient goals of care, and decreased health care spending are benefits of palliative care. Palliative care is appropriate for anyone with a serious illness. Advances in technology and pharmaceuticals have resulted in increasing numbers of seriously ill individuals, many with a high symptom burden. The numbers of individuals who could benefit from palliative care far outweighs the number of palliative care specialists. To integrate palliative care into primary care it is essential that resources are available to improve generalist palliative care skills, identify appropriate patients and refer complex patients to specialist palliative care providers.

  12. Biologists napping while work militarized. (United States)

    Dando, Malcolm


    As researchers discover more agents that alter mental states, the Chemical Weapons Convention needs modification to help ensure that the life sciences are not used for hostile purposes, says Malcolm Dando.

  13. Wound Care. (United States)

    Balsa, Ingrid M; Culp, William T N


    Wound care requires an understanding of normal wound healing, causes of delays of wound healing, and the management of wounds. Every wound must be treated as an individual with regard to cause, chronicity, location, and level of microbial contamination, as well as patient factors that affect wound healing. Knowledge of wound care products available and when negative pressure wound therapy and drain placement is appropriate can improve outcomes with wound healing. Inappropriate product use can cause delays in healing. As a wound healing progresses, management of a wound and the bandage material used must evolve.

  14. Symptom monitoring and self-care practices among Filipino cancer patients. (United States)

    Williams, Phoebe D; Balabagno, Araceli O; Manahan, Lydia; Piamjariyakul, Ubolrat; Ranallo, Lori; Laurente, Cecilia M; Cajucom, Loyda; Guela, Daisy; Kimbrough, Mercedita; Williams, Arthur R


    The purpose of this study was to assess patient-reported symptoms and self-care methods used during cancer treatments, using checklists. A descriptive study was performed at the cancer institute of a national medical center in Manila on 100 patients undergoing combined radiotherapy and chemotherapy, n = 37, or chemotherapy alone, n = 63. Instruments used were (a) 25-item patient-reported Therapy-Related Symptoms Checklist (TRSC), (b) Self-care Methods (with the 25 TRSC items) tool, (c) Karnofsky Scale, (d) Demographic form, and (e) Health form. The TRSC (Philippine version) Cronbach alpha = .83. The TRSC scores inversely, significantly correlated with nurse-rated Karnofsky measure of functional status (r = -0.45; P < .001)-all evidences of internal consistency reliability, construct, and concurrent validity; similar findings were found in Midwestern United States and 2 other Asian settings. Compared with those receiving chemotherapy alone, patients who had combined radiotherapy and chemotherapy reported more symptoms with greater severity on several TRSC subscales. Self-care methods most used were in 2 categories: (a) diet/nutrition/lifestyle change (eg, modify food/eating habits; eat vegetables and fruits (papaya); use nutritional supplements; have naps, rest, sleep) to manage eating, oropharynx, nausea, and fatigue subscale symptoms; and (b) mind/body control (eg, prayer, praying the rosary, music) to relieve fatigue subscale, other symptoms. The TRSC (Philippine version) and Self-care Methods assess patient-reported symptoms and patients' self-care use. Oncology symptom management is enhanced by a valid clinical assessment tool.

  15. Hospice Care (United States)

    ... Hospice is a combination of services designed to address not only the physical needs of patients, but also the psychosocial needs of patients, their loved ones. Hospice combines pain control, symptom ... plan to address each patient’s individual needs. The hospice care team ...

  16. Respite Care (United States)

    ... provided in a home, an adult day-care program or over a weekend in a nursing home or an assisted living facility. For more information on the NFCSP visit the Administration on Aging website at ...

  17. Prenatal Care. (United States)

    Health Resources and Services Administration (DHHS/PHS), Rockville, MD. Office for Maternal and Child Health Services.

    This booklet is the first in a series of publications designed to provide parents with useful information about childrearing. Contents are organized into three parts. Part I focuses on the pregnancy, prenatal care, development of the baby, pregnant lifestyles, nutrition, common discomforts, and problems of pregnancy. Part II provides information…

  18. Entre Hacienda Real y poderes locales: los intentos de reformar las finanzas municipales del reino de Napóles en los siglos XVI y XVII

    Directory of Open Access Journals (Sweden)

    Gaetano SABATINI


    Full Text Available RESUMEN: Durante los sesenta años de transición entre los siglos XVI y XVII se concentran los mayores esfuerzos llevados a cabo en la edad de los Austrias para aumentar el control del poder central sobre la gestión de las finanzas municipales del reino de Napóles, con la doble finalidad de garantizar la regularidad del producto fiscal proveniente de las comunidades y, al mismo tiempo, constituir una reserva de capitales a la cual el soberano pudiera acceder con facilidad y con condiciones menos onerosas que las aplicadas habitualmente por los banqueros. Ambas finalidades son la consecuencia de las crecientes exigencias financieras de la Corona que se registran en el mismo período y que llevan a un crecimiento rápido y vertiginoso de los recursos enviados fuera de los límites del reino, principalmente a Lombardía o a Flandes, para asistir a los ejércitos de la Monarquía. A pesar de la determinación demostrada, la Hacienda Real nunca consigue controlar de una forma completa las finanzas urbanas, sobre todo por la oposición de los poderes económicos —tanto de la capital y como de las provincias del reino— que habrían resultado afectados. A partir de los años 30 del siglo XVII los proyectos de reforma se retiran a cambio del compromiso de los patriciados de las ciudades de cobrar los impuestos y enviarlos a la Corte del modo más puntual. Profundizar en las modalidades a través de las cuales estos proyectos de reformas son llevados a cabo,aunque de modo inacabado, permite comprender mejor la índole de las finanzas urbanas como espacio de poder contendido entre élites dirigentes ciudadanas y Hacienda Real.ABSTRACT: The most important efforts to reform the urban finances realized in the Kingdom of Naples at the time of Spanish rule were done between 1570 and 1630. The increasing financial needing, due to an enormous military expense, obliged the Spanish Monarchy to make any attempt in order to insure the regularity of the tax

  19. FastStats: Hospice Care (United States)

    ... Day Services Centers Home Health Care Hospice Care Nursing Home Care Residential Care Communities Screenings Mammography Pap Tests Disability ... Care National Study of Long-Term Care Providers Nursing Home Care Residential Care Communities Centers for Medicare and Medicaid ...

  20. Interaction between composite elements in the napA promoter: both the B-box ABA-responsive complex and the RY/G complex are necessary for seed-specific expression. (United States)

    Ezcurra, I; Ellerström, M; Wycliffe, P; Stålberg, K; Rask, L


    During seed maturation, the transcriptional activity of napin genes is regulated by developmental signals involving the transcriptional activator ABI3 and abscisic acid (ABA). To localize cis elements involved in the seed-specific activity of the napin napA promoter, a systematic analysis was performed focusing on two major element complexes, the B-box and RY/G. Substitution mutation analysis using promoter-reporter gene fusions in stable transgenic tobacco showed synergistic interactions between elements within these complexes. The distal part of the B-box shows similarities to abscisic acid response elements and the proximal portion contains a CA-rich element. In vitro studies involving Exonuclease III protection and electrophoretic mobility shift assays revealed binding by nuclear proteins to elements within the B-box. The distal and proximal parts of the B-box were found to bind distinct nuclear protein complexes. By gain-of-function analysis with a tetramer of the B-box fused to a truncated (-46) cauliflower mosaic virus (CaMV) 35S minimal promoter, it was demonstrated that the B-box mediates strong activity in seeds. Further, it was shown that the elements in the B-box constitute an ABA-responsive complex, since the B-box tetramer mediates ABA-responsiveness in vegetative tissues to a construct containing the CaMV virus 35S enhancer (-343 to -90). Thus, the seed-specific activity of the napA promoter relies on the combinatorial interaction between the RY/G complex and the B-box ABA-responsive complex during the ABA response in seed development.

  1. Diversity and abundance of nitrate reductase genes (narG and napA), nitrite reductase genes (nirS and nrfA), and their transcripts in estuarine sediments. (United States)

    Smith, Cindy J; Nedwell, David B; Dong, Liang F; Osborn, A Mark


    Estuarine systems are the major conduits for the transfer of nitrate from agricultural and other terrestrial-anthropogenic sources into marine ecosystems. Within estuarine sediments some microbially driven processes (denitrification and anammox) result in the net removal of nitrogen from the environment, while others (dissimilatory nitrate reduction to ammonium) do not. In this study, molecular approaches have been used to investigate the diversity, abundance, and activity of the nitrate-reducing communities in sediments from the hypernutrified Colne estuary, United Kingdom, via analysis of nitrate and nitrite reductase genes and transcripts. Sequence analysis of cloned PCR-amplified narG, napA, and nrfA gene sequences showed the indigenous nitrate-reducing communities to be both phylogenetically diverse and also divergent from previously characterized nitrate reduction sequences in soils and offshore marine sediments and from cultured nitrate reducers. In both the narG and nrfA libraries, the majority of clones (48% and 50%, respectively) were related to corresponding sequences from delta-proteobacteria. A suite of quantitative PCR primers and TaqMan probes was then developed to quantify phylotype-specific nitrate (narG and napA) and nitrite reductase (nirS and nrfA) gene and transcript numbers in sediments from three sites along the estuarine nitrate gradient. In general, both nitrate and nitrite reductase gene copy numbers were found to decline significantly (P < 0.05) from the estuary head towards the estuary mouth. The development and application, for the first time, of quantitative reverse transcription-PCR assays to quantify mRNA sequences in sediments revealed that transcript numbers for three of the five phylotypes quantified were greatest at the estuary head.

  2. Careful science?

    DEFF Research Database (Denmark)

    Jespersen, Astrid P; Bønnelycke, Julie; Eriksen, Hanne Hellerup


    Concern about obesity has prompted numerous public health campaigns that urge people to be more physically active. The campaigns often include normative statements and attempt to impose restrictions on individuals' lives without considering the complexities of daily life. We suggest that broadening...... into different exercise groups. In this article we analyse the scientific work of the trial as representing entangled processes of bodywork, where data are extracted and objectified bodies are manipulated and care practices address the emotional, social and mundane aspects of the participants' everyday lives...

  3. Medical Care during Pregnancy (United States)

    ... 1- to 2-Year-Old Medical Care During Pregnancy KidsHealth > For Parents > Medical Care During Pregnancy A ... both moms and their babies. Prenatal Care Before Pregnancy Prenatal care should start before you get pregnant. ...

  4. Home Care Services (United States)

    Home care is care that allows a person with special needs stay in their home. It might be for people who are getting ... chronically ill, recovering from surgery, or disabled. Home care services include Personal care, such as help with ...

  5. What is palliative care? (United States)

    Comfort care; End of life - palliative care; Hospice - palliative care ... The goal of palliative care is to help people with serious illnesses feel better. It prevents or treats symptoms and side effects of disease and ...

  6. Cancer treatment, symptom monitoring, and self-care in adults: pilot study. (United States)

    Williams, Phoebe Dauz; Piamjariyakul, Ubolrat; Ducey, Kathleen; Badura, Jody; Boltz, Kristin D; Olberding, Karmen; Wingate, Anita; Williams, Arthur R


    A descriptive study was conducted on self-reported symptoms and self-care by 37 adults receiving chemotherapy primarily for leukemia, lymphomas, or breast cancer or radiation therapy for head and neck or lung cancers. The Therapy-Related Symptom Checklist and demographic and interview forms on self-care for identified symptoms were used. Severe symptoms on the Therapy-Related Symptom Checklist subscales fatigue, eating, nausea, pain, numbness in fingers/toes, hair loss, and constipation were reported by patients on chemotherapy. Those on radiation therapy reported severe symptoms on the eating, fatigue, skin changes, oropharynx, and constipation subscales.Self-care strategies were in the following categories, using complementary medicine as framework: diet/nutrition/lifestyle change (eg, use of nutritional supplements; modifications of food and of eating habits; naps, sleep, and rest); mind/body control (eg, relaxation methods, prayer, music, attending granddaughter's sports events); biologic treatments (vitamins); herbal treatments (green mint tea); and ethnomedicine (lime juice and garlic). The first category was predominantly used by patients in both treatment types. Medications were prescribed also to help control symptoms (eg, pain and nausea). Symptom monitoring and self-care for symptoms identified may be facilitated by the Therapy-Related Symptom Checklist; based on reported symptom severity, care providers may prioritize interventions. A larger study needs to be done on (a) the use of the Therapy-Related Symptom Checklist as a clinical tool to assess symptoms that oncology patients experience during therapy; (b) whether care providers, based on patient-reported symptom severity, can prioritize interventions--and how this influences the efficiency of care; (c) the self-care strategies used by patients on chemotherapy or radiation therapy or both; and (d) how useful these strategies are in alleviating symptoms.

  7. Palliative wound care: principles of care. (United States)

    Dale, Barbara; Emmons, Kevin R


    Home care nursing occurs in a complex care environment. Nurses working in this setting care for a wide array of individuals who often are sicker and more complex than ever before. The high prevalence of wounds among these individuals requires that home care nurses have a certain level of knowledge to provide excellent care. Many times, individuals with wounds do not have the capacity to heal or are burdened with numerous symptoms affecting quality of life. In these cases, the home care nurse must understand concepts of palliative wound care to alleviate symptoms with the goal of improving quality of life.

  8. Perioperative Care of Prisoners: Providing Safe Care. (United States)

    Smith, Francis Duval


    Correctional nurses are trained to care for prisoners in a controlled security environment; however, when a convict is transferred to a noncorrectional health care facility, the nurses there are often unfamiliar with custody requirements or how to safely care for these patients. The care of prisoners outside of prison has not been adequately investigated, and a gap exists between research and nursing education and practice. Nurses rarely have to consider how providing care for a prisoner in custody affects their practice, the potential dissonance between routine nursing care and the requirements to maintain security, or that care of prisoners in unsecured clinical areas places the nurse and other personnel at risk for physical assault or prisoner escape. Educating perioperative nurses in the care of prisoners in a public hospital environment is important for the provision of safe care and prevention of physical and emotional repercussions to personnel.

  9. Physical activity in child-care centers: do teachers hold the key to the playground? (United States)

    Copeland, Kristen A; Kendeigh, Cassandra A; Saelens, Brian E; Kalkwarf, Heidi J; Sherman, Susan N


    Many (56%) US children aged 3-5 years are in center-based childcare and are not obtaining recommended levels of physical activity. In order to determine what child-care teachers/providers perceived as benefits and barriers to children's physical activity in child-care centers, we conducted nine focus groups and 13 one-on-one interviews with 49 child-care teachers/providers in Cincinnati, OH. Participants noted physical and socio-emotional benefits of physical activity particular to preschoolers (e.g. gross motor skill development, self-confidence after mastery of new skills and improved mood, attention and napping after exercise) but also noted several barriers including their own personal attitudes (e.g. low self-efficacy) and preferences to avoid the outdoors (e.g. don't like hot/cold weather, getting dirty, chaos of playground). Because individual teachers determine daily schedules and ultimately make the decision whether to take the children outdoors, they serve as gatekeepers to the playground. Participants discussed a spectrum of roles on the playground, from facilitator to chaperone to physical activity inhibitor. These findings suggest that children could have very different gross motor experiences even within the same facility (with presumably the same environment and policies), based on the beliefs, creativity and level of engagement of their teacher.

  10. A Preliminary Study on Foraging Habitat of White-napped Crane on Spring in Qixinghe, Heilongjiang Province%黑龙江七星河春季白枕鹤觅食生境初步研究

    Institute of Scientific and Technical Information of China (English)

    徐景海; 赵国辉; 李晓民


    White-napped Crane (Grus vipio)is a large wader. Because of habitat loss, its global population is declining and is now endangered. White -napped Crane is listed in CITES Appendix I (which bans all international trade in the species ) is categorized as Endangered in the IUCN Red list, and is also list-ed in the First Category of Protected Birds in China. During April to May 2011, the foraging habitat of White-napped Crane was investigated using GPS and direct observation at Qixinghe National Nature Reserve, Helongjiang Province. 70 plots (1m ×1m) were established for sampling vegetation. Factors of its foraging habitat including vegetation species, height, coverage, density, water depth and human disturbance were measured and analyzed by quadrate sampling and factor analysis methods. Results indicated that Grus vipio mainly foraging in the wetlands which have Carex spp., Calamagrostis angustifolia. The height of these plants was between 40cm to 80cm, the density was higher than 600 plants per square meter, vegetation cover was mainly between 0 and 25%, and the depth of the foraging place water was 5~15cm, the distance of human disturbance was greater than 1500m. Human activity greatly affects Grus vipio foraging. In spring, Grus vipio sometimes foraging in the burns down.%  白枕鹤(Grus vipio)为大型涉禽,由于栖息地丧失,数量减少,已被CITES列为附录I,IUCN红皮书列为全球濒危物种,并被列为国家II级重点保护鸟类;2011年4~5月,笔者在七星河自然保护区对白枕鹤春季觅食地生境进行了调查;采用GPS定位技术和直接观察法对白枕鹤栖息生境进行测定,共获取70个1m×1m的样方,利用样方法和因子测定法测定其春季觅食地植物的类型、高度、盖度、植物密度、水深、人为干扰距离等。结果显示:白枕鹤春季主要在以苔草、小叶章为主的沼泽湿地中觅食;最佳觅食地植被高度为40~80cm,植被密度高于600株/m2,植被盖度为0

  11. Acne - self-care (United States)

    Acne vulgaris - self-care; Cystic acne - self-care; Pimples - self-care; Zits - self-care ... If daily skin care does not clear up blemishes, try over-the-counter acne medicines that you apply to your skin. These products ...

  12. Understanding palliative care. (United States)

    Martin, Caren McHenry


    While most pharmacists and other health care practitioners are familiar with the programs and philosophy of hospice, they may lack a clear understanding of palliative care. Because myths and misconceptions about palliative care abound, a review of the definitions and components of palliative care can enhance the practice of all practitioners who care for patients with chronic diseases.


    Institute of Scientific and Technical Information of China (English)

    陈小亮; 谷麟; 王艳; 朱南文; 楼紫阳


    Zeolite is effective in the ammonia removal in waste water treatment process, while the raw materials for the zeolite are limited. In this work, bottom ash from the incineration plant for sewage sludge was applied to produce NaP1 zeolite and Gisomdine by traditional hydrothermal reaction and the index of correlation were characterized. According to the X-ray diffraction, the scanning electron microscopy (SEM) images and the infrared spectroscopy analysis, zeolite NaP1 and Gismondine were predominated in these products with the radial crystal structure and the zeolitic framework structure. The specific surface area and the cation exchange capacity values of the zeolite was 93.8 mZ-g-1 and 126 mmol.100 g-1, with 47 times and 17 times more than that of the sludge before combustion. In addition, the analysis of adsorption isothermal curves of NH4+ was demonstrated that synthesised zeolite had a good potential for ammonia adsorption at 25 ~C, and the maximum quantity for NH4+ removal was 34.9 mg-g-1 ,which also provides an effective way for the utilization of sludge incineration ash.%本文以污泥焚烧残渣为原料,以传统水热合成方法制得NaPl型沸石和水钙沸石,并对其相关指标进行表征.经x射线衍射、扫描电镜和红外光谱测定表明,制得的产物为无其它杂晶生成的NaPl型沸石和水钙沸石,且具有放射束片状晶体形貌和沸石骨架结构.与原污泥焚烧残渣相比,合成沸石的比表面积和阳离子交换容量提高了47倍、17倍,分别达到93.8m^2·g^-1、126mmol·100g^-1.而合成沸石在25℃下对氨氮的吸附等温线结果显示,其氨氮的最大吸附量为34.9mg·g^-1,吸附性能良好.从而本研究也为实现污泥焚烧残渣的再生资源化提供了一条有效途径.

  14. Emergency care toolkits. (United States)

    Black, Steven


    Emergency care services are the focus of a series of toolkits developed by the NHS National electronic Library for Health to provide resources for emergency care leads and others involved in modernising emergency care, writes Steven Black.

  15. Your cancer care team (United States)

    ... gov/ency/patientinstructions/000929.htm Your cancer care team To use the sharing features on this page, ... help your body heal. Working with Your Care Team Each member of your care team plays an ...

  16. Office of Child Care (United States)

    ... for Children & Families Office of Child Care By Office Administration for Native Americans (ANA) Administration on Children, ... Care Partnerships. Review the profiles. > What is the Office of Child Care (OCC)? The Office of Child ...

  17. Developing the Care in Pharmaceutical Care. (United States)

    Fjortoft, Nancy F.; Zgarrick, David P.

    The purpose of this study was to assess the level of caring ability of a sample of pharmacy students and assess the relationship between selected predictor variables and pharmacy students' caring ability. Caring was viewed as the ability to assume responsibility for the protection and welfare of another without being perfunctory or begrudging.…

  18. Putting the 'care' back into aged care. (United States)

    Beadnell, Cathy


    Aged care is well and truly back on the political agenda in Australia. While the mainstream media has recently exposed a number of horrific cases of alleged abuse in aged care facilities it has done little to highlight the failings of social policy over time or to foster debate on how to improve the care of older Australians. What are the barriers to providing safe and quality aged care to a growing number of our citizens and how do we overcome them? If you relied on the recent media coverage for your impression of aged care you could be forgiven for thinking it is all bad news. But there are facilities providing high quality care and stories of nurses working wonders in the face of adversity. Cathy Beadnell considers some of the broader cultural and workforce issues in aged care.

  19. Spiritual Care Education of Health Care Professionals

    Directory of Open Access Journals (Sweden)

    Donia Baldacchino


    Full Text Available Nurses and health care professionals should have an active role in meeting the spiritual needs of patients in collaboration with the family and the chaplain. Literature criticizes the impaired holistic care because the spiritual dimension is often overlooked by health care professionals. This could be due to feelings of incompetence due to lack of education on spiritual care; lack of inter-professional education (IPE; work overload; lack of time; different cultures; lack of attention to personal spirituality; ethical issues and unwillingness to deliver spiritual care. Literature defines spiritual care as recognizing, respecting, and meeting patients’ spiritual needs; facilitating participation in religious rituals; communicating through listening and talking with clients; being with the patient by caring, supporting, and showing empathy; promoting a sense of well-being by helping them to find meaning and purpose in their illness and overall life; and referring them to other professionals, including the chaplain/pastor. This paper outlines the systematic mode of intra-professional theoretical education on spiritual care and its integration into their clinical practice; supported by role modeling. Examples will be given from the author’s creative and innovative ways of teaching spiritual care to undergraduate and post-graduate students. The essence of spiritual care is being in doing whereby personal spirituality and therapeutic use of self contribute towards effective holistic care. While taking into consideration the factors that may inhibit and enhance the delivery of spiritual care, recommendations are proposed to the education, clinical, and management sectors for further research and personal spirituality to ameliorate patient holistic care.

  20. Pediatric intensive care. (United States)

    Macintire, D K


    To provide optimal care, a veterinarian in a pediatric intensive care situation for a puppy or kitten should be familiar with normal and abnormal vital signs, nursing care and monitoring considerations, and probable diseases. This article is a brief discussion of the pediatric intensive care commonly required to treat puppies or kittens in emergency situations and for canine parvovirus type 2 enteritis.

  1. About Skin-to-Skin Care (Kangaroo Care) (United States)

    ... Size Email Print Share About Skin-to-Skin Care Page Content Article Body You may be able ... care, also called kangaroo care. What is Kangaroo Care? Kangaroo care was developed in South America as ...

  2. The Affordable Care Act and integrated care. (United States)

    Kuramoto, Ford


    The Patient Protection and Affordable Care Act (ACA) of 2010 offers a comprehensive, integrated health insurance reform program for those who are eligible to enroll. A core feature of the ACA is the integration of primary health, behavioral health, and related services in a new national program for the first time. This article traces the history of past federal services integration efforts and identify varying approaches for implementing them to improve care, especially for underserved populations. The business case for integrated care, reducing escalating health care costs and overcoming barriers to implementation, is also discussed.

  3. The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile.

    Directory of Open Access Journals (Sweden)

    Glen P Carter


    Full Text Available Nosocomial infections are increasingly being recognised as a major patient safety issue. The modern hospital environment and associated health care practices have provided a niche for the rapid evolution of microbial pathogens that are well adapted to surviving and proliferating in this setting, after which they can infect susceptible patients. This is clearly the case for bacterial pathogens such as Methicillin Resistant Staphylococcus aureus (MRSA and Vancomycin Resistant Enterococcus (VRE species, both of which have acquired resistance to antimicrobial agents as well as enhanced survival and virulence properties that present serious therapeutic dilemmas for treating physicians. It has recently become apparent that the spore-forming bacterium Clostridium difficile also falls within this category. Since 2000, there has been a striking increase in C. difficile nosocomial infections worldwide, predominantly due to the emergence of epidemic or hypervirulent isolates that appear to possess extended antibiotic resistance and virulence properties. Various hypotheses have been proposed for the emergence of these strains, and for their persistence and increased virulence, but supportive experimental data are lacking. Here we describe a genetic approach using isogenic strains to identify a factor linked to the development of hypervirulence in C. difficile. This study provides evidence that a naturally occurring mutation in a negative regulator of toxin production, the anti-sigma factor TcdC, is an important factor in the development of hypervirulence in epidemic C. difficile isolates, presumably because the mutation leads to significantly increased toxin production, a contentious hypothesis until now. These results have important implications for C. difficile pathogenesis and virulence since they suggest that strains carrying a similar mutation have the inherent potential to develop a hypervirulent phenotype.

  4. Kidney stones - self-care (United States)

    ... self-care; Nephrolithiasis and self-care; Stones and kidney - self-care; Calcium stones and self-care; Oxalate ... provider or the hospital because you have a kidney stone. You will need to take self-care ...

  5. Genital herpes - self-care (United States)

    Herpes - genital -self-care; Herpes simplex - genital - self-care; Herpesvirus 2 - self-care; HSV-2 - self-care ... genital herpes can be treated. Follow your health care provider's instructions for treatment and follow-up.

  6. Teamwork in health care. (United States)

    Landman, Natalie; Aannestad, Liv K; Smoldt, Robert K; Cortese, Denis A


    It is becoming increasingly clear that maintaining and improving the health of the population, and doing so in a financially sustainable manner, requires the coordination of acute medical care with long-term care, and social support services, that is, team-based care. Despite a growing body of evidence on the benefits of team-based care, the health care ecosystem remains "resistant" to a broader implementation of such care models. This resistance is a function of both system-wide and organizational barriers, which result primarily from fragmentation in reimbursement for health care services, regulatory restrictions, and the siloed nature of health professional education. To promote the broader adoption of team-based care models, the health care system must transition to pay for value reimbursement, as well as break down the educational silos and move toward team-based and value-based education of health professionals.

  7. Research on Pre-reproduction behavior of White-napped in Qi xinghe Wetland%七星河湿地白枕鹤繁殖前期行为研究

    Institute of Scientific and Technical Information of China (English)

    赵国辉; 李晓民


      2012年4月15日~25日在七星河湿地对白枕鹤的繁殖前期行为规律进行了观察.繁殖前期的时间分配中觅食行为43.55%,警戒行为15.18%,游走行为13.79%,理羽行为12.20%,静栖行为11.81%,求偶行为2.48%,其余行为比较少;日节律显示:觅食行为在一天中出现三次高峰,即6:00~7:00、11:00~13:00和14:00~16:00;警戒行为和静栖行为则有一定程度的相似,分别在13:00和14:00左右,达到峰值;游走行为在下午达到低谷,在其他时间趋于稳定;理羽行为在一天中基本趋于稳定.求偶行为只出现在早晨和傍晚之间有两个间断峰值,无规律性.雌雄白枕鹤在理羽行为(p=0.018)和求偶行为(p=0.001)时间分配上存在显著性差异.其余行为时间分配上不存在显著性差异.%  The rhythm of behaviors of White-napped Crane in pre-reproductive period was observed at April 15~25, 2012 in Qi xinghe Wetland. The time budget of various behaviors in pre-re-productive stage was feeding (43.55%), alert (15.18%), walking (13.79%), preening (12.20%), resting (11.81% ), courtship (2.48%), and the else behaviors was rare. The behavior rhythm of White-napped Crane showed that feeding in one day appeared three peaks at 6:00~7:00, 11:00~13:00 and 14:00~16:00. Alert and resting were similar in the certain degree, respectively reached the peak at 13:00 and 14:00. Walking reached the trough at pm and then kept steady in other times. Preening tended to keep steady in a day. Courtship only had two discontinuous peaks and non-regularity. Significant difference was found for female and male between preening (p=0.018) and courtship (p=0.001). There was no significant difference in else behaviors.

  8. Research in cardiovascular care

    DEFF Research Database (Denmark)

    Jaarsma, Tiny; Deaton, Christi; Fitzsimmons, Donna


    To deliver optimal patient care, evidence-based care is advocated and research is needed to support health care staff of all disciplines in deciding which options to use in their daily practice. Due to the increasing complexity of cardiac care across the life span of patients combined...... of the body of knowledge that is needed to further improve cardiovascular care. In this paper, knowledge gaps in current research related to cardiovascular patient care are identified, upcoming challenges are explored and recommendations for future research are given....

  9. Personal Care in Learning Health Care Systems. (United States)

    Miller, Franklin G; Kim, Scott Y H


    The idea of a "learning health care system"--one that systematically integrates clinical research with medical care--has received considerable attention recently. Some commentators argue that under certain conditions pragmatic comparative effectiveness randomized trials can be conducted ethically within the context of a learning health care system without the informed consent of patients for research participation. In this article, we challenge this perspective and contend that conducting randomized trials of individual treatment options without consent is neither necessary nor desirable to promote and sustain learning health care systems. Our argument draws on the normative conception of personal care developed by Charles Fried in a landmark 1974 book on the ethics of randomized controlled trials.

  10. FastStats: Home Health Care (United States)

    ... Day Services Centers Home Health Care Hospice Care Nursing Home Care Residential Care Communities Screenings Mammography Pap Tests Disability ... Care National Study of Long-Term Care Providers Nursing Home Care Residential Care Communities Centers for Medicare and Medicaid ...

  11. Managed care demands flexibility, creativity. (United States)


    The definition of hospice care is changing as home care providers come under managed care regulations. Hospice care for AIDS patients is demanding, requiring extra time from home care providers. The managed care cost-cutting measures require creativitity and patience. The Visiting Nurses and Hospice of San Francisco (VNH) has held seminars to help providers adapt to managed care.

  12. Surgical Critical Care Initiative (United States)

    Federal Laboratory Consortium — The Surgical Critical Care Initiative (SC2i) is a USU research program established in October 2013 to develop, translate, and validate biology-driven critical care....

  13. US EPA CARE Grants (United States)

    U.S. Environmental Protection Agency — This is a provisional dataset that contains point locations for the subset of Community Action for a Renewed Environment (CARE) grants given out by the US EPA. CARE...

  14. Day Care Centers (United States)

    Department of Homeland Security — This database contains locations of day care centers for 50 states and Washington D.C. and Puerto Rico. The dataset only includes center based day care locations...

  15. Children's hospice care. (United States)

    Armstrong-Dailey, A


    Facing the inevitable death of a child is a difficult reality for many parents and health care providers as well. Children's Hospice International offers a variety of information and education services to support the provision of children's hospice care.

  16. Does Care Matter?

    DEFF Research Database (Denmark)

    Loft, Lisbeth Trille Gylling; Hogan, Dennis P.


    employment during the first 36 weeks following a birth, and its association with experienced non-parental child care use before labor force entry. Using data from the Early Childhood Longitudinal Survey – Birth Cohort (N = 10,400 mothers), results from discrete-time hazard models show that use of non......The aim of this study is to introduce the concept of care capital and provide an example of its application in the context of child care and maternal employment using the currently most suitable American data. We define care capital as the nexus of available, accessible, and experienced resources...... for care. The American setting is an ideal context to investigate the linkages between child care capital and maternal employment as the patterns of child care use tend to be more diverse compared to other national context. In the presented application of care capital, we examine mothers’ entry to paid...

  17. National Health Care Survey (United States)

    This survey encompasses a family of health care provider surveys, including information about the facilities that supply health care, the services rendered, and the characteristics of the patients served.

  18. Value of care - National (United States)

    U.S. Department of Health & Human Services — Value of care displays – national data. This data set includes national-level data for the value of care displays associated with a 30-day episode of care for...

  19. Critical Care Team (United States)

    ... Patients and Families > About Critical Care > Team Tweet Team Page Content ​The critical care team is a group of specially trained caregivers who ... help very ill patients get better. The care team often teach the patient and family strategies that ...

  20. Child Care Services Handbook. (United States)

    Duval County School Board, Jacksonville, FL.

    A companion document to the curriculum guide for a secondary level child care services curriculum, this handbook contains a variety of administrative and program resources for the teacher: The vocational curriculum outline for child care services; a calendar of suggested public relations activities; procedures for building child care services…

  1. Hospice Care in America (United States)

    ... Patient receives hospice care consisting predominantly of licensed nursing care on a continuous basis at home. Continuous home ... Gozalo PL, Mor V. The Growth of Hospice Care in U.S. Nursing Homes . JAGS. 2010 58:1481-88. © 2015 NHPCO ...

  2. Finnish care integrated?

    Directory of Open Access Journals (Sweden)

    Jouni Niskanen


    Full Text Available The public Finnish social and health care system has been challenged by the economic crisis, administrative reforms and increased demands. Better integration as a solution includes many examples, which have been taken to use. The most important are the rewritten national and municipals strategies and quality recommendations, where the different sectors and the levels of care are seen as one entity. Many reorganisations have taken place, both nationally and locally, and welfare clusters have been established. The best examples of integrated care are the forms of teamwork, care management, emphasis on non-institutional care and the information technology.

  3. Neuroeconomics and Integrated Care

    DEFF Research Database (Denmark)

    Larsen, Torben


    of integrated home care for stroke patients. Results: (1) The classical understanding of CNS is that of a dual system of ANS and Cortex. The new neuroeconomic understanding is that of a reciprocal balance of Limbic System (LS) and Neocortex (NC). This applies directly in favour of integrated homecare compared......Background: Fragmented specialized care for the frail elderly as claimed by WHO needs horizontal integration across settings. The home of the patient seems to be a promising place to integrate hospital care, primary care and social services for high-risk discharges where the quality...... of rehabilitation makes a difference. Objective: The study aims to reveal how integrated home care may be organised to improve quality of care as compared to usual hospital care. Method: A qualitative case study of the use of a neuroeconomic model in relation to multidisciplianry collaboration on a RCT...

  4. The Epital Care Model

    DEFF Research Database (Denmark)

    Phanareth, Klaus; Vingtoft, Søren; Christensen, Anders Skovbo


    and organizations that provide health care. Technology may be a way to enable the creation of a coherent, cocreative, person-centered method to provide health care for individuals with one or more long-term conditions (LTCs). It remains to be determined how a new care model can be introduced that supports...... the intentions of the World Health Organization (WHO) to have integrated people-centered care. OBJECTIVE: To design, pilot, and test feasibility of a model of health care for people with LTCs based on a cocreative, iterative, and stepwise process in a way that recognizes the need for person-centered care...... and face-to-face support for COPD management. In step five the initial model was extended with elements that support continuity of care. Beginning in the autumn of 2013, 1102 frail elderly individuals were included and offered two additional services: an outgoing acute medical team and a local subacute bed...

  5. Acute care nurses' spiritual care practices. (United States)

    Gallison, Barry S; Xu, Yan; Jurgens, Corrine Y; Boyle, Suzanne M


    The purpose of this study was to identify barriers in providing spiritual care to hospitalized patients. A convenience sample (N = 271) was recruited at an academic medical center in New York City for an exploratory, descriptive questionnaire. The Spiritual Care Practice (SCP) questionnaire assesses spiritual care practices and perceived barriers to spiritual care. The SCP determines the percentage that provides spiritual support and perceived barriers inhibiting spiritual care. The participation rate was 44.3% (N = 120). Most (61%) scored less than the ideal mean on the SCP. Although 96% (N = 114) believe addressing patients spiritual needs are within their role, nearly half (48%) report rarely participating in spiritual practices. The greatest perceived barriers were belief that patient's spirituality is private, insufficient time, difficulty distinguishing proselytizing from spiritual care, and difficulty meeting needs when spiritual beliefs were different from their own. Although nurses identify themselves as spiritual, results indicate spirituality assessments are inadequate. Addressing barriers will provide nurses opportunities to address spirituality. Education is warranted to improve nurses' awareness of the diversity of our society to better meet the spiritual needs of patients. Understanding these needs provide the nurse with opportunities to address spirituality and connect desires with actions to strengthen communication and the nurse-patient relationship.

  6. Timely and Effective Care - National (United States)

    U.S. Department of Health & Human Services — Timely and Effective Care measures - national data. This data set includes national-level data for measures of heart attack care, heart failure care, pneumonia care,...

  7. Timely and Effective Care - Hospital (United States)

    U.S. Department of Health & Human Services — Timely and Effective Care measures - provider data. This data set includes provider-level data for measures of heart attack care, heart failure care, pneumonia care,...

  8. Broken toe - self-care (United States)

    Fractured toe - self-care; Broken bone - toe - self-care; Fracture - toe - self-care; Fracture phalanx - toe ... often treated without surgery and can be taken care of at home. Severe injuries include: Breaks that ...

  9. Timely and Effective Care - State (United States)

    U.S. Department of Health & Human Services — Timely and Effective Care measures - state data. This data set includes state-level data for measures of heart attack care, heart failure care, pneumonia care,...

  10. 全睡眠剥夺30小时后不同时长恢复性小睡对青年男性睡眠惯性的影响%Effects of sleep inertia on cognitive performance following different time course naps after 30 hours sleep deprivation in healthy men

    Institute of Scientific and Technical Information of China (English)

    常大川; 王文昭; 贺斌; 赵忠新; 包旭芳; 郑良成; 张鹏; 张琳; 李雁鹏; 吴惠涓; 庄建华


    course sleeps on sleep stages and cognitions in healthy men after 30 h sleep deprivation,and also to investigate the mechanism of cognitive functions impairment in sleep inertia stages and the influential factors of sleep inertia.Methods Ten healthy men (age,(20.8 ±2.1) years) participated in the program.The program was divided into 2 stages.First,participants attended a series of tests after 20 min nap(20 min nap group)after 30 h sleep deprivation.The testing series included 3 parts:the continuous performance task,the Stroop Tests,and the Addition Tests.The series of tests were done 3 times immediately after the volunteers were awoken and each lasted about 15 minutes with an interval of 10 minutes between each test.The polysomnogram (PSG) was recorded during the nap.The following 7 days was set as washing-out period to ensure a complete recovery.Participants repeated the similar processes with 2 h nap(2 h nap group) instead of 20 min nap.The cognitive performance of each group was compared with each other along with the best cognitive performance in awakening to estimate whether or not the cognitive abilities regained the normal condition.Results ( 1 ) Sleep latency became shortened in both groups after 30 h sleep deprivation.There were no slow wave sleep (SWS) and rapid eye movement sleep (REM) sleep stages in the 20 min naps,while the percentage of SWS was increased and percentage of REM declined in 2 h naps.(2)In the early of SI (5 min after awaking),cognitive tasks showed that the abilities of continuous attention,selected attention and addition ability were all impaired (continuous performance task:(371.8 ± 21.3 ) times/3 min vs (334.4 ± 22.4) times/3 min,( 373.2 ± 19.0) times/3 min vs ( 323.7 ± 23.8) times/3 min,t =10.443,7.774,both P<0.01; Stroop tests:(20.3 ±1.5) points vs(17.3 ± 1.0) points,(21.5 ±0.8)points vs( 16.1 ± 1.4 ) points,t =8.478,4.934,both P < 0.05 ; Addition Tests:( 222.2 ± 13.2 ) s vs ( 266.6 ±23.7 ) s,( 226.3 ± 10.9) s vs ( 267

  11. The concept of care

    Directory of Open Access Journals (Sweden)

    Georgia Kiparisi


    Full Text Available Introduction: From the literature review it derives that the concept of care is multidimensional. Every individual forms a specific attitude towards care depending on the particular social framework he/she has been raised in as well as his/her religious beliefs and cultural background. The theoretical framework of the research is based on both selected terms of meaning of “care” as well as on selected principles of intercultural Nursing care as they have been described by Leininger (1997. According to Leininger, Nursing care as a phenomenon is met in all civilizations while there are particular cultural care standards. The aim of this research is semantic determination of care and therefore, how the Greeks perceive the meaning of Care.Methodology: To answer the above research questions, we chose the approach of phenomenological research method. The collection of data has been accomplished with the method of interviews with open questions. Then, the analysis of the interview data followed in accordance to the technique of content analysis with the Mayring method (summary.Result: From the content analysis the following categories derived:1. Care means love2. Care means understanding3. Care means prevention4. Care means touchConclusions: The semantic approach of care as it is perceived from the individuals, accentuates in fact the thesis that the philosophy of nursing science is based on ideals and universal values, whose respect from the professional ensures high quality in provided care and promotes the nursing work for the benefit of the individual and the society, too.

  12. Advance Care Planning. (United States)

    Stallworthy, Elizabeth J


    Advance care planning should be available to all patients with chronic kidney disease, including end-stage kidney disease on renal replacement therapy. Advance care planning is a process of patient-centred discussion, ideally involving family/significant others, to assist the patient to understand how their illness might affect them, identify their goals and establish how medical treatment might help them to achieve these. An Advance Care Plan is only one useful outcome from the Advance Care Planning process, the education of patient and family around prognosis and treatment options is likely to be beneficial whether or not a plan is written or the individual loses decision making capacity at the end of life. Facilitating Advance Care Planning discussions requires an understanding of their purpose and communication skills which need to be taught. Advance Care Planning needs to be supported by effective systems to enable the discussions and any resulting Plans to be used to aid subsequent decision making.

  13. Danish Palliative Care Database

    DEFF Research Database (Denmark)

    Grønvold, Mogens; Adsersen, Mathilde; Hansen, Maiken Bang


    Aims: The aim of the Danish Palliative Care Database (DPD) is to monitor, evaluate, and improve the clinical quality of specialized palliative care (SPC) (ie, the activity of hospital-based palliative care teams/departments and hospices) in Denmark. Study population: The study population is all......, and the patient-reported European Organisation for Research and Treatment of Cancer Quality of Life Questionaire-Core-15-Palliative Care questionnaire, assessing health-related quality of life. The data support the estimation of currently five quality of care indicators, ie, the proportions of 1) referred......-Core-15-Palliative Care at admission to SPC, and 5) patients who were discussed at a multidisciplinary conference. Descriptive data: In 2014, all 43 SPC units in Denmark reported their data to DPD, and all 9,434 cancer patients (100%) referred to SPC were registered in DPD. In total, 41,104 unique cancer...

  14. Improving Care for Children With Complex Needs (United States)


    Medically Complex Children; Care Coordination; Case Manager; Care Manager; Collaborative Care; Disease Management; Patient Care Team or Organization; Managed Care; Children With Chronic Conditions; Children With Special Health Care Needs; Shared Care Plan; Patient Care Plan; Health Care and Resource Utilization; Adherence to Care; Functional Status and Productivity; Health Related Quality of Life; Satisfaction With Care; Care Coordinator; Family Experience of Care; Quality Health Care

  15. Integrated and interprofessional care

    Directory of Open Access Journals (Sweden)

    Hugh Barr


    Full Text Available No wonder two movements described in such similar terms are so often confused. One strives to knit services together, the other to cultivate collaborative practice amongst their workers.  Dedicated though both of them are to the improvement of health and social care, integrated care falters without engaging the workforce actively as partners in change whilst interprofessional care falters without organisational support. Neither stands alone. Each depends on the other.

  16. Music in child care


    Maria Polikandrioti; Ioannis Koutelekos


    Music has been used therapeutically for many centuries, and numerous studies have researched the curative and preventative powers of music in several diseases. Music, as a therapy was shown to have positive effects in child care, such as in premature infants, children in emergency care, children receiving surgery, children in oncology departments and handicapped children. The aim of this review was to study the therapeutic effects of music in child care at hospital. The method οf this study i...

  17. The meaning of care dependency as shared by care givers and care recipients : a concept analysis

    NARCIS (Netherlands)

    Boggatz, Thomas; Dijkstra, Ate; Lohrmann, Christa; Dassen, Theo


    Aim. This paper is a report of a concept analysis to identify a meaning of care dependency that can be shared by both care givers and care recipients. Background. Care dependency can be perceived from the care recipient's and the care giver's perspective. To allow for comparisons, both sides should

  18. Penis care (uncircumcised) (United States)

    Uncircumcised penis - bathing; Cleaning an uncircumcised penis ... An uncircumcised penis has its foreskin intact. An infant boy with an uncircumcised penis does not need special care. Normal bathing ...

  19. Crossing the caring chasm

    DEFF Research Database (Denmark)

    Kitson, Alison; Sørensen, Erik Elgaard


    upon prevention and screening, the trend will continue to be around providing care and support for individuals, families and communities for chronic and life-style induced diseases. The emphasis will therefore be on the need for evidence-based care as much as evidence-based medicine (or cure......). By definition, patients with chronic conditions cannot be cured; this means their fundamental care needs are at the centre of their course of care and hence, nursing (Henderson 1966). This article is protected by copyright. All rights reserved....

  20. Nursing Care after Death



    Nurses care, help and support patients before they are born, when they are alive and after they die. The starting points of this study were how nurses provide physical care for the dead patients and psychological care for the bereaved families. The purpose of this study was to describe the role of a nurse when patients die. The aims of this study were that the results of the study could help the nurses’ clinical work and could be used as part of teaching material in post-mortem care or nu...

  1. Nap sleep spindle correlates of intelligence

    NARCIS (Netherlands)

    Ujma, P.P.; Bodizs, R.; Gombos, F.; Stintzing, J.; Konrad, B.N.; Genzel, L.; Steiger, A.; Dresler, M.


    Sleep spindles are thalamocortical oscillations in non-rapid eye movement (NREM) sleep, that play an important role in sleep-related neuroplasticity and offline information processing. Several studies with full-night sleep recordings have reported a positive association between sleep spindles and fl

  2. Health care marketing management. (United States)

    Cooper, P D


    Health Care Marketing Management is the process of understanding the needs and the wats of a target market. Its purpose is to provide a viewpoint from which to integrate the analysis, planning, implementation (or organization) and control of the health care delivery system.

  3. Lean health care. (United States)

    Hawthorne, Henry C; Masterson, David J


    Principles of Lean management are being adopted more widely in health care as a way of improving quality and safety while controlling costs. The authors, who are chief executive officers of rural North Carolina hospitals, explain how their organizations are using Lean principles to improve quality and safety of health care delivery.

  4. Prevention IS Care

    Centers for Disease Control (CDC) Podcasts


    This podcast provides an overview of the Prevention IS Care campaign, which provides HIV prevention tools for medical care providers to use on a daily basis with patients who are living with HIV.  Created: 3/26/2009 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 3/26/2009.

  5. Wound Healing and Care (United States)

    ... Loss Surgery? A Week of Healthy Breakfasts Shyness Wound Healing and Care KidsHealth > For Teens > Wound Healing and Care Print A A A What's in ... mouth, or sunken eyes. There's good news about wound healing when you're a teen: Age is on ...

  6. Child Care Aware (United States)

    ... a stream of our activity across multiple social networks by visiting the Child Care Aware® of America Social Dashboard. Visit Our Social Dashboard Follow and Engage ... Care Aware of America Home Newsroom Contact Us Log In Register Back About ...

  7. Robots that care

    NARCIS (Netherlands)

    Looije, R.; Arendsen, J.; Saldien, J.; Vanderborght, B.; Broekens, J.; Neerincx, M.


    Many countries face pressure on their health care systems. To alleviate this pressure, 'self care' and 'self monitoring' are often stimulated with the use of new assistive technologies. Social robotics is a research area where robotic technology is optimized for various social functions. One of thes

  8. Primary Care's Dim Prognosis (United States)

    Alper, Philip R.


    Given the chorus of approval for primary care emanating from every party to the health reform debate, one might suppose that the future for primary physicians is bright. Yet this is far from certain. And when one looks to history and recognizes that primary care medicine has failed virtually every conceivable market test in recent years, its…

  9. Child Care Centres. (United States)

    Australian Dept. of Labour and National Service, Melbourne. Women's Bureau.

    Based on a survey of legislation relating to full-day care for preschool children of working mothers and a study of records, this report: (1) covers the number of registered child care centers in Australia and the number of children being served, (2) sets the conditions applying to registration of centers, (3) indicates the extent and levels of…

  10. Finding Health Care Services (United States)

    If you have been diagnosed with cancer, finding a doctor and treatment facility for your cancer care is an important step to getting the best treatment possible. Learn tips for choosing a doctor and treatment facility to manage your cancer care.

  11. [Home care in Sapporo]. (United States)

    Yazaki, Kazuo


    We established a clinic specialized in home care in Sapporo in July 2001. In these 2 years we have provided medical home care service to 160 patients, and 97 are still receiving regular service. At first we accepted any patients living within 16 km from the clinic. However, bad traffic conditions in winter made it difficult to visit patients living in districts far away from the clinic. Therefore, we planned a network of home care physicians in Sapporo. Now 12 home care physicians hold monthly meetings. In Sapporo, meetings of home care related workers are organized in each ward, as suggested by the Sapporo Medical Association. There is a relatively good supply of home care related services and resources, including availability of an important number of visiting nurses. Patients being taken care of at home who present an acute exacerbation of symptoms are relatively easily accepted by acute hospitals. But those who have difficulties in continuing home care due to a sudden change in family conditions are not easily accepted by nursing hospitals. Recently, the number of group homes and lodging houses for elderly persons has markedly increased in Sapporo. It might have some problems in medical support in the near future.

  12. Alliance in Youth Care

    NARCIS (Netherlands)

    Rothman, Linda; Rijsingen, Rinie van; Pijnenburg, Huub


    This article introduces the concept of alliance in youth care. The concept of (therapeutic) alliance originates in adult psychotherapy and related research. Alliance refers to the working relationship between youth care workers and their clients. Within this concept, personal (emotional) and task re

  13. Improved wound care product

    DEFF Research Database (Denmark)


    The present invention pertains to use of sodium diacetate (NaHAc 2) as an antimicrobial agent against bacteria growing in biofilms. The aspects of the invention include a wound care product comprising sodium diacetate, a kit comprising a wound care product,and a methodof treating an infected wound....

  14. Care, Europeanization and Gender

    DEFF Research Database (Denmark)

    Dyrberg, Torben Bech

    This book adresses the recent underexamined developments concerning care in Europe, including the negotiations about care at the top EU level to that of individual workers. Through a comparative and interdisciplinary approach, this collection examines and further develops current theoretical and ...

  15. Caring about the young

    NARCIS (Netherlands)

    John Stevens; Evert Pommer; Hetty van Kempen; Elke Zeijl; Isolde Woittiez; Klarita Sadiraj; Rob Gilsing; Saskia Keuzenkamp


    Original title: De jeugd een zorg. Youth care services are going through major changes. This has created a need for a better insight into the demand that is likely to be placed on these services in the future at both national and regional level. This report suggests that the use of ambulant care w

  16. Benchmarking HIV health care

    DEFF Research Database (Denmark)

    Podlekareva, Daria; Reekie, Joanne; Mocroft, Amanda


    ABSTRACT: BACKGROUND: State-of-the-art care involving the utilisation of multiple health care interventions is the basis for an optimal long-term clinical prognosis for HIV-patients. We evaluated health care for HIV-patients based on four key indicators. METHODS: Four indicators of health care were...... assessed: Compliance with current guidelines on initiation of 1) combination antiretroviral therapy (cART), 2) chemoprophylaxis, 3) frequency of laboratory monitoring, and 4) virological response to cART (proportion of patients with HIV-RNA 90% of time on cART). RESULTS: 7097 Euro...... to North, patients from other regions had significantly lower odds of virological response; the difference was most pronounced for East and Argentina (adjusted OR 0.16[95%CI 0.11-0.23, p HIV health care utilization...

  17. Becoming Care Helper

    DEFF Research Database (Denmark)

    Jensen, Anne Winther

    The paper discusses the shaping of students´ identity within a vocational education programme for elderly care in Denmark. The focus is on the correlation between identity construction within the theoretical periods and students´ experiences in the traineeships. In the school setting the future...... care helper is being constructed within the overall term ‘professional’, but students may meet differing ways of being care helper in the traineeships, and the paper points to an ongoing struggle about the definition of ‘being care helper’. The analysis of the identity issues mobilises the concepts...... ‘positioning’ and ‘storyline’, c.f. Bronwyn Davies, and the empirical material consists of interviews and observations in the theoretical periods and in the traineeships. The paper suggests that a shift from identity to subjectivity may help students to deal with the diversity of ‘care helpers’ and thereby...

  18. "Patient care in radiology"

    DEFF Research Database (Denmark)

    Bro Brask, Kirsten; Birkelund, Regner


    The aim of this study was to research how the staff experience care expressed during the brief encounter with the patients in a diagnostic imaging department. This was a qualitative study with a phenomenological and hermeneutical frame of reference. The data were collected using field observations...... and semistructured interviews and analyzed according to the guidelines for meaning condensation by Giorgi. The imaging staff found that care is expressed in an administrative, an instrumental, and a compassionate sense. The imaging staff perceived care in a way that clearly differs from the traditional perception...... of care understood as the close relations between people. In their self-understanding, the staff found that care not only comprised the relational aspect but also that it was already delivered during the preparatory phases before the actual meeting with the patient and up until the image...

  19. Managed care and economic dynamics. (United States)

    Riggs, J E


    Over the past several decades, health care delivery in the United States evolved in an environment lacking marketplace constraints. The unforeseen result was the current health care crisis--uncontrolled costs, shrinking access, and redundant technological capabilities. Managed care is a strategy to impose fiscal constraints on health care delivery. A diagrammatic analysis of the economic dynamics between consumers and producers in an open marketplace is compared with that of patients, providers, and payers under the health care scheme that produced the health care crisis and under managed care. Patient demands, expectations, and needs for health care are not subject to fiscal constraint under managed care since the dislinkage between consumer and payer still exits. Managed care does not impose true open marketplace fiscal constraints on health care delivery. Furthermore, any solution to the US health care crisis that used true marketplace fiscal constraints would necessitate fundamental changes in societal values concerning individual rights to health care.

  20. Palliative Care: Video Tells a Mother's Story of Caring Support (United States)

    ... care, and when is it provided? Palliative care combines pain and symptom management with spiritual support, counseling, ... fully understand your needs. Read More "Palliative Care" Articles Increasing the quality of life for patients and ...

  1. Primary care for refugees. (United States)

    Eckstein, Barbara


    Over the past decade, at least 600,000 refugees from more than 60 different countries have been resettled in the United States. The personal history of a refugee is often marked by physical and emotional trauma. Although refugees come from many different countries and cultures, their shared pattern of experiences allows for some generalizations to be made about their health care needs and challenges. Before being accepted for resettlement in the United States, all refugees must pass an overseas medical screening examination, the purpose of which is to identify conditions that could result in ineligibility for admission to the United States. Primary care physicians have the opportunity to care for members of this unique population once they resettle. Refugees present to primary care physicians with a variety of health problems, including musculoskeletal and pain issues, mental and social health problems, infectious diseases, and longstanding undiagnosed chronic illnesses. Important infectious diseases to consider in the symptomatic patient include tuberculosis, parasites, and malaria. Health maintenance and immunizations should also be addressed. Language barriers, cross-cultural medicine issues, and low levels of health literacy provide additional challenges to caring for this population. The purpose of this article is to provide primary care physicians with a guide to some of the common issues that arise when caring for refugee patients.

  2. Advocacy for eye care

    Directory of Open Access Journals (Sweden)

    Thulasiraj D Ravilla


    Full Text Available The effectiveness of eye care service delivery is often dependant on how the different stakeholders are aligned. These stakeholders range from the ministries of health who have the capacity to grant government subsidies for eye care, down to the primary healthcare workers who can be enrolled to screen for basic eye diseases. Advocacy is a tool that can help service providers draw the attention of key stakeholders to a particular area of concern. By enlisting the support, endorsement and participation of a wider circle of players, advocacy can help to improve the penetration and effectiveness of the services provided. There are several factors in the external environmental that influence the eye care services - such as the availability of trained manpower, supply of eye care consumables, government rules and regulations. There are several instances where successful advocacy has helped to create an enabling environment for eye care service delivery. Providing eye care services in developing countries requires the support - either for direct patient care or for support services such as producing trained manpower or for research and dissemination. Such support, in the form of financial or other resources, can be garnered through advocacy.

  3. Primary Care Clinics and Accountable Care Organizations

    Directory of Open Access Journals (Sweden)

    Judith Ortiz PhD


    Full Text Available Background: The Accountable Care Organization (ACO is one of the new models of health care delivery in the United States. To date, little is known about the characteristics of health care organizations that have joined ACOs. We report on the findings of a survey of primary care clinics, the objective of which was to investigate the opinions of clinic management about participation in ACOs and the characteristics of clinic organizational structure that may contribute to joining ACOs or be willing to do so. Methods: A 27-item survey questionnaire was developed and distributed by mail in 3 annual waves to all Rural Health Clinics (RHCs in 9 states. Two dependent variables—participation in ACOs and willingness to join ACOs—were created and analyzed using a generalized estimating equation approach. Results: A total of 257 RHCs responded to the survey. A small percentage (5.2% of the respondent clinics reported that they were participating in ACOs. Rural Health Clinics in isolated areas were 78% less likely to be in ACOs (odds ratio = 0.22, P = .059. Nonprofit RHCs indicated a higher willingness to join an ACO than for-profit RHCs (B = 1.271, P = .054. There is a positive relationship between RHC size and willingness to join an ACO (B = 0.402, P = .010. Conclusion: At this early stage of ACO development, many RHC personnel are unfamiliar with the ACO model. Rural providers’ limited technological and human resources, and the lack of ACO development in rural areas, may delay or prevent their participation in ACOs.

  4. Hair care and dyeing. (United States)

    Draelos, Zoe Diana


    Alopecia can be effectively camouflaged or worsened through the use of hair care techniques and dyeing. Proper hair care, involving hair styling and the use of mild shampoos and body-building conditioners, can amplify thinning scalp hair; however, chemical processing, including hair dyeing, permanent waving, and hair straightening, can encourage further hair loss through breakage. Many patients suffering from alopecia attempt to improve their hair through extensive manipulation, which only increases problems. Frequent haircuts to minimize split ends, accompanied by gentle handling of the fragile fibers, is best. This chapter offers the dermatologist insight into hair care recommendations for the alopecia patient.


    Institute of Scientific and Technical Information of China (English)


    IN April, the Beijing Education Commission, Beijing Women’s Federation and the China Institute of Family Education jointly decided the theme of China’s family education for 1997: Learn to care and teach good behavior. This theme reminds us of the requirement of young generations in many other countries: Learn to survive, learn to care. It reveals that learning to care about others is not only a problem faced by Chinese children, most of whom grow up as an only child, but is a common problem in children’s education

  6. Health care utilization

    DEFF Research Database (Denmark)

    Jacobsen, Christian Bøtcher; Andersen, Lotte Bøgh; Serritzlew, Søren

    An important task in governing health services is to control costs. The literatures on both costcontainment and supplier induced demand focus on the effects of economic incentives on health care costs, but insights from these literatures have never been integrated. This paper asks how economic cost...... make health professionals provide more of this service to each patient, but that lower user payment (unexpectedly) does not necessarily mean higher total cost or a stronger association between the number of patients per supplier and the health care utilization. This implies that incentives...... are important, but that economics cannot alone explain the differences in health care utilization....

  7. Glossary of Managed Care Definitions (United States)

    ... care provided to a patient by a health care provider. The medical record includes notes from physician visits, hospitalization records, test results, and consultations by specialists. Each health care provider who treats a patient usually creates and maintains ...

  8. Your cancer survivorship care plan (United States)

    ... ency/patientinstructions/000822.htm Your cancer survivorship care plan To use the sharing features on this page, ... get one. What Is a Cancer Survivorship Care Plan? A cancer survivorship care plan is a document ...

  9. Identifying health care quality attributes. (United States)

    Ramsaran-Fowdar, Roshnee R


    Evaluating health care quality is important for consumers, health care providers, and society. Developing a measure of health care service quality is an important precursor to systems and organizations that value health care quality. SERVQUAL has been proposed as a broad-based measure of service quality that may be applicable to health care settings. Results from a study described in this paper verify SERVQUAL dimensions, but demonstrate additional dimensions that are specific to health care settings.

  10. Affordable Care Act (ACA) (United States)

    Social Security Administration — The Affordable Care Act (ACA) is a federal statute enacted with a goal of increasing the quality and affordability of health insurance. Through a web service, CMS...

  11. Radiation therapy -- skin care (United States)

    ... this page: // Radiation therapy - skin care To use the sharing features ... this page, please enable JavaScript. When you have radiation treatment for cancer, you may have some changes ...

  12. Caring for the Caregiver (United States)

    ... Dictionary of Cancer Terms NCI Drug Dictionary NCI Dictionary of Genetics Terms ... care to a person with cancer. It is a condensed version of our booklet, When Someone You Love Is Being Treated for Cancer . Being a caregiver ...

  13. Contact Lens Care (United States)

    ... Más! Novelas An Invitation to Collaborate Free Publications English Publications Spanish Publications Publications in Other Languages Take Time to Care Program College Women's Health Pink Ribbon Sunday Program Women's ...

  14. Diabetic Wound Care (United States)

    ... and between the toes—for cuts, bruises, cracks, blisters, redness, ulcers, and any sign of abnormality. Each time you visit a health-care provider, remove your shoes and socks so your feet can be examined. ...

  15. Your Health Care Team (United States)

    ... Disease (Nephropathy) Gastroparesis Mental Health Step On Up Treatment & Care Blood Glucose Testing Medication Doctors, Nurses & More ... us get closer to curing diabetes and better treatments for those living with diabetes. Other Ways to ...

  16. American Health Care Association (United States)

    ... Care Association Responds to Ruling on Injunction Delaying CMS Implementation of Arbitration Rule AHCA/NCAL Elects New ... Information Technology Integrity Medicaid Medicare Patient Privacy and Security Survey and Regulatory Therapy Services Workforce Events Calendar ...

  17. Resilient health care

    DEFF Research Database (Denmark)

    Hollnagel, E.; Braithwaite, J.; Wears, R. L.

    engineering's unique approach emphasises the usefulness of performance variability, and that successes and failures have the same aetiology. This book contains contributions from acknowledged international experts in health care, organisational studies and patient safety, as well as resilience engineering......Health care is everywhere under tremendous pressure with regard to efficiency, safety, and economic viability - to say nothing of having to meet various political agendas - and has responded by eagerly adopting techniques that have been useful in other industries, such as quality management, lean...... production, and high reliability. This has on the whole been met with limited success because health care as a non-trivial and multifaceted system differs significantly from most traditional industries. In order to allow health care systems to perform as expected and required, it is necessary to have...

  18. Shared care and boundaries:

    DEFF Research Database (Denmark)

    Winthereik, Brit Ross


    and technology studies. Findings – The paper shows how a version of “the responsible patient” emerges from the project which is different from the version envisioned by the project organisation. The emerging one is concerned with the boundary between primary and secondary sector care, and not with the boundary...... of healthcare in relation to IT design. Originality/value – The paper shows that “unshared” care does not exist; care is always shared among human and nonhuman actors. It also points to the value of studying how boundaries are enacted in projects that seek to create continuity across boundaries. Udgivelsesdato......Purpose – The paper seeks to examine how an online maternity record involving pregnant women worked as a means to create shared maternity care. Design/methodology/approach – Ethnographic techniques have been used. The paper adopts a theoretical/methodological framework based on science...

  19. Hospice Care in America (United States)

    ... 50 patients per year to large, national corporate chains that care for thousands of patients each day. ... spiritual aspects of dying • Provides needed drugs, medical supplies, and equipment • Instructs the family on how to ...

  20. Dementia - daily care (United States)

    ... this page: // Dementia - daily care To use the sharing features on ... prevent choking. Tips for Talking With Someone With Dementia Keep distractions and noise down: Turn off the ...

  1. Moving survivorship care plans forward: focus on care coordination. (United States)

    Salz, Talya; Baxi, Shrujal


    After completing treatment for cancer, the coordination of oncology and primary care presents a challenge for cancer survivors. Many survivors need continued oncology follow-up, and all survivors require primary care. Coordinating the shared care of a cancer survivor, or facilitating an informed handoff from oncology to primary care, is essential for cancer survivors. Survivorship care plans are personalized documents that summarize cancer treatment and outline a plan of recommended ongoing care, with the goal of facilitating the coordination of post-treatment care. Despite their face validity, five trials have failed to demonstrate the effectiveness of survivorship care plans. We posit that these existing trials have critical shortcomings and do not adequately address whether survivorship care plans improve care coordination. Moving forward, we propose four criteria for future trials of survivorship care plans: focusing on high-needs survivor populations, tailoring the survivorship care plan to the care setting, facilitating implementation of the survivorship care plan in clinical practice, and selecting appropriate trial outcomes to assess care coordination. When trials meet these criteria, we can finally assess whether survivorship care plans help cancer survivors receive optimal oncology and primary care.

  2. Empowering and caring professionals

    DEFF Research Database (Denmark)

    Hansen, Agnete Meldgaard

    A wave of policies to reform municipal elderly care services is sweeping across Denmark. Under headings such as ‘help for self-help’, ‘everyday rehabilitation’, and ‘re-ablement’, municipalities are working to make their elderly citizens more self-reliant, active and less dependent on municipal c...... of municipal care budgets; as normative experts; as efficient housewives performing practical tasks; and as sympathetic listeners who fulfil the elderly’s needs for contact and empathy....

  3. Teamwork for eye care

    Directory of Open Access Journals (Sweden)

    M Babar Qureshi


    Full Text Available Human resource development (HRD – the development of the people who deliver health care – has been identified as one of the key pillars of eye health delivery. HRD is one of the essential building blocks of the World Health Organization (WHO Global Action Plan: ‘Towards universal eye health’. The importance of HRD is also recognised beyond eye care, as can be seen in the WHO Health Systems approach.

  4. Nursing care community health

    Directory of Open Access Journals (Sweden)

    Diana Acosta-Salazar


    Full Text Available Process Nursing Care (PAE is a systematic tool that facilitates the scientificity of care in community practice nurse, the application of scientific method in community practice, allows nursing to provide care in logical, systematic and comprehensive reassessing interventions to achieve the proposed results. It began with the valuation of Marjory Gordon Functional Patterns and then at the stage of diagnosis and planning North American Nursing Diagnosis Association (NANDA, Nursing Interventions Classification (NIC and Nursing Outcomes Classification (NOC is interrelate. It is a descriptive and prospective study. Diagnosis was made by applying the instruments measuring scale of the socio-demographic characteristics, symptom questionnaire for early detection of mental disorders in the community and appreciation for functional patterns. The PAE includes more frequent diagnoses, criteria outcomes, indicators, interventions and activities to manage community issues. alteration was evidenced in patterns: Adaptation and Stress Tolerance, Self-perception-Self-concept-, Role-Relationships, sleep and rest and Perception and Health Management. A standardized NANDA-NIC-NOC can provide inter care holistic care from the perspective of community mental health with a degree of scientific nature that frames the professional work projecting the individual, family and community care.

  5. Wound care in horses. (United States)

    Caston, Stephanie S


    Care of equine wounds in the field can be a challenging endeavor. Many times, wound care is complicated by chronicity or by prior inappropriate care in addition to the great degree of tissue trauma that occurred when the horse was wounded. Recognizing involvement of synovial structures, loss of skin, and damage to bone are critical in the initial examination of wounds and will guide future care. Education of clients is also important in that preparing them for possible outcomes during healing may help improve compliance and proper treatment of wound. Owners and trainers often perform much of the daily care and monitoring of equine wounds and thus can greatly assist or impede the progress. Bandaging is important to management of equine wounds-especially on the limbs-and is sometimes overlooked because of its labor-intensive nature and the desire for a spray, ointment, or salve that will heal the wound. The practitioner that improves and utilizes his or her understanding of the wound-healing process in concert with his or her knowledge of local anatomy will be the one who is best equipped to care for wounds in ambulatory practice.

  6. Pastoral care, spirituality, and religion in palliative care journals.

    NARCIS (Netherlands)

    Hermsen, M.A.; Have, H.A.M.J. ten


    With the growth and development of palliative care, interest in pastoral care, spirituality, and religion also seems to be growing. The aim of this article is to review the topic of pastoral care, spirituality, and religion appearing in the journals of palliative care, between January 1984 and Janua

  7. Pediatric Primary Care as a Component of Systems of Care (United States)

    Brown, Jonathan D.


    Systems of care should be defined in a manner that includes primary care. The current definition of systems of care shares several attributes with the definition of primary care: both are defined as community-based services that are accessible, accountable, comprehensive, coordinated, culturally competent, and family focused. However, systems of…

  8. Primary care nurses: effects on secondary care referrals for diabetes?

    NARCIS (Netherlands)

    Dijk, C.E. van; Verheij, R.A.; Hansen, J.; Velden, L. van der; Nijpels, G.; Groenewegen, P.P.; Bakker, D.H. de


    BACKGROUND: Primary care nurses play an important role in diabetes care, and were introduced in GP-practice partly to shift care from hospital to primary care. The aim of this study was to assess whether the referral rate for hospital treatment for diabetes type II (T2DM) patients has changed with t

  9. Primary care nurses : effects on secondary care referrals for diabetes

    NARCIS (Netherlands)

    Dijk, C.E. van; Verheij, R.A.; Hansen, J.; Velden, L. van der; Nijpels, G.; Groenewegen, P.P.; Bakker, D.H. de


    Background: Primary care nurses play an important role in diabetes care, and were introduced in GP-practice partly to shift care from hospital to primary care. The aim of this study was to assess whether the referral rate for hospital treatment for diabetes type II (T2DM) patients has changed with t

  10. A Vocational Calling: Exploring a Caring Technology in Elderly Care (United States)

    Fejes, Andreas; Nicoll, Katherine


    In this article we explore the relationship of care of a group of health care workers in elderly care, through their descriptions of themselves and their work. We have an interest in how relationships of care may be explored and characterised in and across disparate vocational settings. This is a critical response to policy discourses of…

  11. Intelligent, Energy Saving Power Supply and Control System of Hoisting Mine Machine with Compact and Hybrid Drive System / Inteligentne, Energooszczędne Układy Zasilania I Sterowania Górniczych Maszyn Wyciągowych Z Napędem Zintegrowanym Lub Hybrydowym (United States)

    Szymański, Zygmunt


    In the paper present's an analysis of suitableness an application of compact and hybrid drive system in hoisting machine. In the paper presented the review of constructional solutions of hoisting machines drive system, driving with AC and DC motor. In the paper presented conception of modern, energy sparing hoisting machine supply system, composed with compact motor, an supplied with transistor or thyristor converter supply system, and intelligent control system composed with multilevel microprocessor controller. In the paper present's also analysis of suitableness application an selected method of artificial intelligent in hoisting machine control system, automation system, and modern diagnostic system. In the paper one limited to analysis of: fuzzy logic method, genetic algorithms method, and modern neural net II and III generation. That method enables realization of complex control algorithms of hosting machine with insurance of energy sparing exploitation conditions, monitoring of exploitation parameters, and prediction diagnostic of hoisting machine technical state, minimization a number of failure states. In the paper present's a conception of control and diagnostic system of the hoisting machine based on fuzzy logic neural set control. In the chapter presented also a selected control algorithms and results of computer simulations realized for particular mathematical models of hoisting machine. Results of theoretical investigation were partly verified in laboratory and industrial experiments. Przedstawiono analizę celowości wprowadzania, napędów zintegrowanych oraz napędów hybrydowych, do układów napędowych maszyn wyciągowych. Zamieszczono przegląd rozwiązań konstrukcyjnych wybranych hybrydowych oraz zintegrowanych napędów maszyn wyciągowych z silnikami DC i AC. Opisano koncepcję nowoczesnego, energooszczędnego układu zasilania górniczych maszyny wyciągowej, złożonego z silnika zintegrowanego, (tranzystorowego lub tyrystorowego

  12. Developing integrated care. Towards a development model for integrated care


    Minkman, Mirella M.N


    textabstractThe thesis adresses the phenomenon of integrated care. The implementation of integrated care for patients with a stroke or dementia is studied. Because a generic quality management model for integrated care is lacking, the study works towards building a development model for integrated care. Based on a systematic approach in which a literature study, a delphi study, a concept mapping study and questionnaire research are combined, a development model for integrated care is created....

  13. Care assistant experiences of dementia care in long-term nursing and residential care environments. (United States)

    Talbot, Rebecca; Brewer, Gayle


    Care assistants have a unique insight into the lives of service users and those factors which may impede or enhance the delivery of high quality dementia oriented care. To address the paucity of research in this area, the present study examined care assistant experiences of dementia care in British long-term residential and nursing environments. Semi-structured interviews were conducted with eight care assistants and transcripts were analysed using interpretive phenomenological analysis. Super-ordinate themes emerging from the data were psychological wellbeing of the care assistant, barriers to effective dementia care, the dementia reality and organisational issues within the care environment. The study revealed important deficiencies in understanding and varying levels of dementia training. Whilst person centred strategies were being implemented, task orientated care remained dominant. Furthermore, care assistants reported taking the perspectives of those with dementia into account, and actively using these to develop relationship centred care.

  14. Primary Medical Care in Chile

    DEFF Research Database (Denmark)

    Scarpaci, Joseph L.

    Primary medical care in Chile: accessibility under military rule [Front Cover] [Front Matter] [Title Page] Contents Tables Figures Preface Chapter 1: Introduction Chapter 2: The Restructuring of Medical Care Financing in Chile Chapter 3: Inflation and Medical Care Accessibility Chapter 4: Help......-Seeking Behavior of the Urban Poor Chapter 5: Spatial Organization and Medical Care Accessibility Chapter 6: Conclusion...

  15. End of Life (Hospice Care) (United States)

    Healthy Lifestyle End of life Hospice care might be an option if you or a loved one has a terminal illness. Understand how hospice care ... care is for people who are nearing the end of life. Hospice care services are provided by a team of health ...

  16. Perspectives on Self-Care (United States)

    Williams, Isha D.; Richardson, Tenille A.; Moore, Darren D.; Gambrel, Laura Eubanks; Keeling, Margaret L.


    Self-care for clinicians is much needed. To discover ways to implement self-care into our lives, we (four therapists) tried different self-care methods over a span of one to two weeks. After using practices that explored self-care through mindfulness meditation, autohypnosis, music, and spirituality, we wrote about the outcome of these experiences…

  17. Maryland Day Care Voucher System. (United States)

    Hildebrand, Joan M.

    This manual was written to assist States and other governmental units wishing to replicate the Maryland Day Care Voucher Program, a system of providing child care subsidies to eligible families. Chapter I provides brief histories of day care in Maryland and that State's grant to demonstrate the viability of a day care voucher system. Chapter II…

  18. The Danish Intensive Care Database

    DEFF Research Database (Denmark)

    Christiansen, Christian Fynbo; Møller, Morten Hylander; Nielsen, Henrik


    AIM OF DATABASE: The aim of this database is to improve the quality of care in Danish intensive care units (ICUs) by monitoring key domains of intensive care and to compare these with predefined standards. STUDY POPULATION: The Danish Intensive Care Database (DID) was established in 2007...

  19. Smart Living in Dementia Care

    NARCIS (Netherlands)

    Nijhof, N.; Hoof, van J; Blom, M.M.; Gemert-Pijnen, van J.E.W.C.; Hoof, van Joost; Demiris, George; Wouters, Eveline J.M.


    In order to provide adequate care and housing to the growing number of people with dementia, new technologies are necessary to provide good care and reduce the costs for these care services. Numerous technologies are available, which decrease the need for care and increase the self-reliance of clien

  20. Primary care research in Denmark

    DEFF Research Database (Denmark)

    Vedsted, Peter; Kallestrup, Per


    International Perspectives on Primary Care Research examines how the evidence base from primary care research can strengthen health care services and delivery, tackle the growing burden of disease, improve quality and safety, and increase a person-centred focus to health care. Demonstrating the i...

  1. Palliative care and spirituality

    Directory of Open Access Journals (Sweden)

    Narayanasamy Aru


    Full Text Available Critical junctures in patients′ lives such as chronic illnesses and advanced diseases may leave the persons in a state of imbalance or disharmony of body, mind and spirit. With regard to spirituality and healing, there is a consensus in literature about the influence of spirituality on recovery and the ability to cope with and adjust to the varying and demanding states of health and illness. Empirical evidence suggests that spiritual support may act as an adjunct to the palliative care of those facing advanced diseases and end of life. In this article, the author draws from his empirical work on spirituality and culture to develop a discourse on palliative care and spirituality in both secular and non-secular settings. In doing so, this paper offers some understanding into the concept of spirituality, spiritual needs and spiritual care interventions in palliative care in terms of empirical evidence. Responding to spiritual needs could be challenging, but at the same time it could be rewarding to both healthcare practitioner (HCP and patient in that they may experience spiritual growth and development. Patients may derive great health benefits with improvements in their quality of life, resolutions and meaning and purpose in life. It is hoped that the strategies for spiritual support outlined in this paper serve as practical guidelines to HCPs for development of palliative care in South Asia.

  2. Managed care under siege. (United States)

    Epstein, R A


    Managed Care Organizations (MCOs) are frequently criticized for their marketing mistakes. Often that criticism is leveled against an implicit benchmark of an ideal competitive market or an ideal system of government provision. But any accurate assessment in the choice of health care organizations always requires a comparative measure of error rates. These are high in the provision of health care, given the inherent uncertainties in both the cost and effectiveness of treatment. But the continuous and rapid evolution of private health care mechanisms is, in the absence of regulation, more likely to secure access and contain costs than any system of government regulation. State regulation is subject to the risk of capture and to the sluggish and acquisitive behavior of state run monopolies. The proposed fixes for the MCOs (rights to specialists, access to physicians outside the network, guaranteed emergency room access) are likely, when imposed from without, to cost more than they are worth. The long-term risk is that markets will fail under regulation, paving the way for greater losses from massive government control of the health care delivery system.

  3. Health care need

    DEFF Research Database (Denmark)

    Hasman, Andreas; Hope, Tony; Østerdal, Lars Peter


    The argument that scarce health care resources should be distributed so that patients in 'need' are given priority for treatment is rarely contested. In this paper, we argue that if need is to play a significant role in distributive decisions it is crucial that what is meant by need can be precis......The argument that scarce health care resources should be distributed so that patients in 'need' are given priority for treatment is rarely contested. In this paper, we argue that if need is to play a significant role in distributive decisions it is crucial that what is meant by need can...... be precisely articulated. Following a discussion of the general features of health care need, we propose three principal interpretations of need, each of which focuses on separate intuitions. Although this account may not be a completely exhaustive reflection of what people mean when they refer to need...

  4. Comprehensive care of travelers. (United States)

    Pust, R E; Peate, W F; Cordes, D H


    Travel, especially if it is international, often means major changes for the family. Family physicians should assess the epidemiologic risk and psychosocial significance of travel or relocation in light of the family's life-cycle stage and antecedent health. Using core references, which are kept current in partnership with public health agencies, family physicians are able to provide comprehensive immunization, medications, and patient education for all travel risks. Families are given medical record summaries and recommended sources of care at their destination. Eight weeks after their return patients are reassessed for newly acquired illness and helped to integrate the perspectives gained during the travel into the family's future dynamics. Taking advantage of growing travel medicine opportunities, family medicine educators should base the care of travelers and teaching of residents on defined competence priorities. Travelers' health provides a mutually rewarding model of shared care with public health consultants in the community medicine curriculum.

  5. Organizing Rural Health Care

    DEFF Research Database (Denmark)

    Bunkenborg, Mikkel


    The liberalization of health care in the course of three decades of ‘reform and opening up’ has given people in rural China access to a diverse range of treatment options, but the health care system has also been marred by accusations of price hikes, fake pharmaceuticals, and medical malpractice....... This chapter offers an ethnographic description of health as an issue in a Hebei township and it focuses on a popular and a statist response to the perceived inadequacy of the rural health care system. The revival of religious practices in rural China is obviously motivated by many factors, but in the township...... in question, various forms of healing play a significant role in religious movements and the rising cost of medical services as well as a general distrust of formal medical institutions seem to be part of the reason why people choose to follow spirit mediums and religious movements that offer alternative...

  6. Mercury and health care. (United States)

    Rustagi, Neeti; Singh, Ritesh


    Mercury is toxic heavy metal. It has many characteristic features. Health care organizations have used mercury in many forms since time immemorial. The main uses of mercury are in dental amalgam, sphygmomanometers, and thermometers. The mercury once released into the environment can remain for a longer period. Both acute and chronic poisoning can be caused by it. Half of the mercury found in the atmosphere is human generated and health care contributes the substantial part to it. The world has awakened to the harmful effects of mercury. The World Health Organization and United Nations Environmental Programme (UNEP) have issued guidelines for the countries' health care sector to become mercury free. UNEP has formed mercury partnerships between governments and other stakeholders as one approach to reducing risks to human health and the environment from the release of mercury and its compounds to the environment. Many hospitals are mercury free now.

  7. Health care reforms

    Directory of Open Access Journals (Sweden)

    Marušič Dorjan


    Full Text Available In large systems, such as health care, reforms are underway constantly. The article presents a definition of health care reform and factors that influence its success. The factors being discussed range from knowledgeable personnel, the role of involvement of international experts and all stakeholders in the country, the importance of electoral mandate and governmental support, leadership and clear and transparent communication. The goals set need to be clear, and it is helpful to have good data and analytical support in the process. Despite all debates and experiences, it is impossible to clearly define the best approach to tackle health care reform due to a different configuration of governance structure, political will and state of the economy in a country.

  8. Health care reforms. (United States)

    Marušič, Dorjan; Prevolnik Rupel, Valentina


    In large systems, such as health care, reforms are underway constantly. The article presents a definition of health care reform and factors that influence its success. The factors being discussed range from knowledgeable personnel, the role of involvement of international experts and all stakeholders in the country, the importance of electoral mandate and governmental support, leadership and clear and transparent communication. The goals set need to be clear, and it is helpful to have good data and analytical support in the process. Despite all debates and experiences, it is impossible to clearly define the best approach to tackle health care reform due to a different configuration of governance structure, political will and state of the economy in a country.

  9. Acupuncture in primary care. (United States)

    Mao, Jun J; Kapur, Rahul


    Acupuncture, an ancient traditional Chinese medical therapy, is used widely around the world. When practiced by a certified provider, it is safe and patients often find it calming and relaxing. Animal and human studies have found a physiologic basis for acupuncture needling in that it affects the complex central and peripheral neurohormonal network. Although it is unclear whether acupuncture is beneficial over sham/placebo acupuncture, acupuncture care yields clinically relevant short- and long-term benefits for low back pain, knee osteoarthritis, chronic neck pain, and headache. The integration of acupuncture into a primary care setting also appears to be cost-effective. The practice of acupuncture in primary care requires rigorous training, financial discipline, and good communication skills. When done correctly, acupuncture is beneficial for both patients and providers.

  10. Mercury and health care

    Directory of Open Access Journals (Sweden)

    Rustagi Neeti


    Full Text Available Mercury is toxic heavy metal. It has many characteristic features. Health care organizations have used mercury in many forms since time immemorial. The main uses of mercury are in dental amalgam, sphygmomanometers, and thermometers. The mercury once released into the environment can remain for a longer period. Both acute and chronic poisoning can be caused by it. Half of the mercury found in the atmosphere is human generated and health care contributes the substantial part to it. The world has awakened to the harmful effects of mercury. The World Health Organization and United Nations Environmental Programme (UNEP have issued guidelines for the countries′ health care sector to become mercury free. UNEP has formed mercury partnerships between governments and other stakeholders as one approach to reducing risks to human health and the environment from the release of mercury and its compounds to the environment. Many hospitals are mercury free now.

  11. Mercury and health care (United States)

    Rustagi, Neeti; Singh, Ritesh


    Mercury is toxic heavy metal. It has many characteristic features. Health care organizations have used mercury in many forms since time immemorial. The main uses of mercury are in dental amalgam, sphygmomanometers, and thermometers. The mercury once released into the environment can remain for a longer period. Both acute and chronic poisoning can be caused by it. Half of the mercury found in the atmosphere is human generated and health care contributes the substantial part to it. The world has awakened to the harmful effects of mercury. The World Health Organization and United Nations Environmental Programme (UNEP) have issued guidelines for the countries’ health care sector to become mercury free. UNEP has formed mercury partnerships between governments and other stakeholders as one approach to reducing risks to human health and the environment from the release of mercury and its compounds to the environment. Many hospitals are mercury free now. PMID:21120080

  12. Burnout and health care utilization. (United States)

    Jackson, C N; Manning, M R


    This study explores the relationship between burnout and health care utilization of 238 employed adults. Burnout was measured by the Maslach Burnout Inventory and health care utilization by insurance company records regarding these employees' health care costs and number of times they accessed health care services over a one year period. ANOVAs were conducted using Golembiewski and Munzenrider's approach to define the burnout phase. Significant differences in health care costs were found.

  13. School Leadership--Balancing Power with Caring. (United States)

    Sernak, Kathleen

    This book examines caring from three perspectives. It opens with a discussion of Nel Noddings's caring tenets--caring is collaborative, situational, reciprocal, and committed--that are seen as necessary for an ethic of caring. A critique of an ethic of caring from the viewpoints of caring with leadership, caring as a "female ethic," caring for a…

  14. NIDCAP and developmental care

    Directory of Open Access Journals (Sweden)

    Dominique Haumont


    Full Text Available Perinatal mortality in very low birth weight infants has dramatically decreased during the last decades. However, 15-25% of these infants will show neurodevelopmental impairment later on. The aim of implementing early developmental care (EDC, emerged as a new field in neonatology, is to create an intervention program designed to provide support for optimal neurobehavioral development during this highly vulnerable period of brain growth. The theoretical framework, which underlies the approach, is supported by research in different scientific fields, including neuroscience, psychology, medicine and nursing. EDC utilizes a range of medical and nursing interventions that aim to decrease the stress of preterm neonates in neonatal intensive care units (NICUs. The Neonatal Individualized Developmental Care Assessment Program (NIDCAP is an integrated and holistic form of family-centered developmental care. Changing the traditional NICU towards an EDC-NICU includes training nursing and medical staff, investing in their quality and most importantly keeping parents in proximity to the infants. The new challenge of modern neonatology is to restore the mother-infant dyad applying “couplet care” starting at birth until discharge. Most of the European NICUs apply some elements of EDC, but it is more consistent in northern Europe. The development of NIDCAP training centers in Europe demonstrates the evolution of care. It is likely that future research and intervention programs will optimize our practices. Developmental care could prove to be an important recent step in improving outcome in extremely preterm neonates. Proceedings of the 10th International Workshop on Neonatology · Cagliari (Italy · October 22nd-25th, 2014 · The last ten years, the next ten years in Neonatology Guest Editors: Vassilios Fanos, Michele Mussap, Gavino Faa, Apostolos Papageorgiou

  15. Pediatric palliative care

    Directory of Open Access Journals (Sweden)

    Trapanotto Manuela


    Full Text Available Abstract The WHO defines pediatric palliative care as the active total care of the child's body, mind and spirit, which also involves giving support to the family. Its purpose is to improve the quality of life of young patients and their families, and in the vast majority of cases the home is the best place to provide such care, but for cultural, affective, educational and organizational reasons, pediatric patients rarely benefit from such an approach. In daily practice, it is clear that pediatric patients experience all the clinical, psychological, ethical and spiritual problems that severe, irreversible disease and death entail. The international literature indicates a prevalence of incurable disease annually affecting 10/10,000 young people from 0 to 19 years old, with an annual mortality rate of 1/10,000 young people from birth to 17 years old. The needs of this category of patients, recorded in investigations conducted in various parts of the world, reveal much the same picture despite geographical, cultural, organizational and social differences, particularly as concerns their wish to be treated at home and the demand for better communications between the professionals involved in their care and a greater availability of support services. Different patient care models have been tested in Italy and abroad, two of institutional type (with children staying in hospitals for treating acute disease or in pediatric hospices and two based at home (the so-called home-based hospitalization and integrated home-based care programs. Professional expertise, training, research and organization provide the essential foundations for coping with a situation that is all too often underestimated and neglected.

  16. Concept caring in nursing

    Directory of Open Access Journals (Sweden)

    Lenka Drahošová


    Full Text Available Aim: The aim of this literature review was to search for qualitative studies focusing on the concept of caring in nursing, to analyse them and to synthesize knowledge that concerns the definition of the concept of caring in nursing from the point of view of nurses and patients. Design: Review. Methods: Qualitative studies were searched for systematically in the electronic databases Academic Search Complete (EBSCO, CINAHL, Medline, Science Direct, and the Wiley Library Online, according to set criteria and defined key words for the period 1970-2015. Seven selected articles were analysed after selection of documents with the aid of a sorting chart. Results: Nurses understand caring in nursing as a relationship with patients which is characterised on the nurses' part by an individual and empathetic approach, attentiveness, experience and sensitivity. Through caring, active communication takes place, providing information which reduces anxiety and leads to the breaking down of barriers. This relationship helps protect patients' autonomy, dignity and comfort. It requires experience on the part of nurses, and it is influenced by the environment. The nurses' personal qualities (what professional knowledge, attitudes and skills they have and their availability, reliability, and emotional and physical support are important to patients. Conclusion: The concept of caring is a content specific interpersonal process which is characterized by the professional knowledge, skills, personal maturity, and interpersonal sensitivity of nurses, which result in the protection, emotional support, and the meeting of bio-psycho-social needs of patients. The results of the overview study could contribute to an explanation and understanding of the nature of caring as a fundamental feature of the discipline of nursing.

  17. Flourishing in health care


    Edgar, Andrew Robert; Pattison, Stephen


    The purpose of this paper is to offer an account of ‘flourishing’ that is relevant to health care provision, both in terms of the flourishing of the individual patient and carer, and in terms of the flourishing of the caring institution. It is argued that, unlike related concepts such as ‘happiness’, ‘well-being’ or ‘quality of life’, ‘flourishing’ uniquely has the power to capture the importance of the vulnerability of human being. Drawing on the likes of Heidegger and Nussbaum, it is argued...

  18. Care and calls

    DEFF Research Database (Denmark)

    Paasch, Bettina Sletten

    In this thesis, Bettina Sletten Paasch conducts research on the use of mobile work phones in the practices of nurses. On-going demands for efficiency have triggered the implementation of multiple technologies in Danish hospitals. One such technology is mobile phones. With care being a key value...... in nursing, a potential tension arises when nurses have to attend simultaneously to both a patient and a ringing mobile work phone. Using discursive and interactional approaches, this thesis explores if and how nurses are able to enact care during interactions with patients when mobile work phones intervene...

  19. Danish Palliative Care Database

    Directory of Open Access Journals (Sweden)

    Groenvold M


    Full Text Available Mogens Groenvold,1,2 Mathilde Adsersen,1 Maiken Bang Hansen1 1The Danish Palliative Care Database (DPD Secretariat, Research Unit, Department of Palliative Medicine, Bispebjerg Hospital, 2Department of Public Health, University of Copenhagen, Copenhagen, Denmark Aims: The aim of the Danish Palliative Care Database (DPD is to monitor, evaluate, and improve the clinical quality of specialized palliative care (SPC (ie, the activity of hospital-based palliative care teams/departments and hospices in Denmark. Study population: The study population is all patients in Denmark referred to and/or in contact with SPC after January 1, 2010. Main variables: The main variables in DPD are data about referral for patients admitted and not admitted to SPC, type of the first SPC contact, clinical and sociodemographic factors, multidisciplinary conference, and the patient-reported European Organisation for Research and Treatment of Cancer Quality of Life Questionaire-Core-15-Palliative Care questionnaire, assessing health-related quality of life. The data support the estimation of currently five quality of care indicators, ie, the proportions of 1 referred and eligible patients who were actually admitted to SPC, 2 patients who waited <10 days before admission to SPC, 3 patients who died from cancer and who obtained contact with SPC, 4 patients who were screened with European Organisation for Research and Treatment of Cancer Quality of Life Questionaire-Core-15-Palliative Care at admission to SPC, and 5 patients who were discussed at a multidisciplinary conference. Descriptive data: In 2014, all 43 SPC units in Denmark reported their data to DPD, and all 9,434 cancer patients (100% referred to SPC were registered in DPD. In total, 41,104 unique cancer patients were registered in DPD during the 5 years 2010–2014. Of those registered, 96% had cancer. Conclusion: DPD is a national clinical quality database for SPC having clinically relevant variables and high data

  20. Caring for Ivan Ilyich. (United States)

    Charlton, Blake; Verghese, Abraham


    For over a century, Leo Tolstoy's The Death of Ivan Ilych has been one of the most influential examinations of how we come to terms with our own mortality. Of the many who care for Ivan Ilych, only the uneducated peasant, Gerasim, is able to help him find meaning and resolution before death. An excerpt that describes Gerasim's key interaction with Ivan Ilych is provided. Analysis of the text reveals how cultural values may hinder a patient's ability to confront mortality and how unique social barriers inhibit different caretakers' ability to care for a dying patient.

  1. Pharmacists belong in accountable care organizations and integrated care teams. (United States)

    Smith, Marie; Bates, David W; Bodenheimer, Thomas S


    Effective health care workforce development requires the adoption of team-based care delivery models, in which participating professionals practice at the full extent of their training in pursuit of care quality and cost goals. The proliferation of such new models as medical homes, accountable care organizations, and community-based care teams is creating new opportunities for pharmacists to assume roles and responsibilities commensurate with their capabilities. Some challenges to including pharmacists in team-based care delivery models, including the lack of payment mechanisms that explicitly provide for pharmacist services, have yet to be fully addressed by policy makers and others. Nevertheless, evolving models and strategies reveal a variety of ways to draw on pharmacists' expertise in such critical areas as medication management for high-risk patients. As Affordable Care Act provisions are implemented, health care workforce projections need to consider the growing number of pharmacists expected to play an increasing role in delivering primary care services.

  2. Integrating rheumatology care in the community: can shared care work?

    Directory of Open Access Journals (Sweden)

    Anita YN Lim


    Full Text Available Introduction: Singapore's rapidly ageing population and chronic disease burden at public hospital specialist clinics herald a silver tsunami. In Singapore, “right siting” aims to manage stable chronic disease in primary care at a lower cost. To improve the quality of rheumatology care, we created shared care between rheumatologist and family physician to reduce hospital visits. Methods: Clinical practice improvement methodology was used to structure shared care of stable patients between hospital rheumatologists and eleven community family physicians; one ran a hospital clinic. A case manager coordinated the workflow. Results: About 220 patients entered shared care over 29 months. Patients without hospital subsidies (private patients and private family physicians independently predicted successful shared care, defined as one cycle of alternating care. Discussion: Our shared care model incorporated a case manager, systematic workflows, patient selection criteria, willing family physician partners and rheumatologists in the absence of organizational integration. Health care affordability impacts successful shared care. Government subsidy hindered right siting to private primary care. Conclusions: Financing systems in Singapore, at health policy level, must allow transfer of hospital subsidies to primary care, both private and public, to make it more affordable than hospital care. Structural integration will create a seamless continuum between hospital and primary care.

  3. Integrating palliative care into the trajectory of cancer care. (United States)

    Hui, David; Bruera, Eduardo


    Over the past five decades, palliative care has evolved from serving patients at the end of life into a highly specialized discipline focused on delivering supportive care to patients with life-limiting illnesses throughout the disease trajectory. A growing body of evidence is now available to inform the key domains in the practice of palliative care, including symptom management, psychosocial care, communication, decision-making, and end-of-life care. Findings from multiple studies indicate that integrating palliative care early in the disease trajectory can result in improvements in quality of life, symptom control, patient and caregiver satisfaction, illness understanding, quality of end-of-life care, survival, and costs of care. In this narrative Review, we discuss various strategies to integrate oncology and palliative care by optimizing clinical infrastructures, processes, education, and research. The goal of integration is to maximize patient access to palliative care and, ultimately, to improve patient outcomes. We provide a conceptual model for the integration of supportive and/or palliative care with primary and oncological care. We also discuss how health-care systems and institutions need to tailor integration based on their resources, size, and the level of primary palliative care available.

  4. Integrating rheumatology care in the community: can shared care work?

    Directory of Open Access Journals (Sweden)

    Anita YN Lim


    Full Text Available Introduction: Singapore's rapidly ageing population and chronic disease burden at public hospital specialist clinics herald a silver tsunami. In Singapore, “right siting” aims to manage stable chronic disease in primary care at a lower cost. To improve the quality of rheumatology care, we created shared care between rheumatologist and family physician to reduce hospital visits.Methods: Clinical practice improvement methodology was used to structure shared care of stable patients between hospital rheumatologists and eleven community family physicians; one ran a hospital clinic. A case manager coordinated the workflow.Results: About 220 patients entered shared care over 29 months. Patients without hospital subsidies (private patients and private family physicians independently predicted successful shared care, defined as one cycle of alternating care.Discussion: Our shared care model incorporated a case manager, systematic workflows, patient selection criteria, willing family physician partners and rheumatologists in the absence of organizational integration. Health care affordability impacts successful shared care. Government subsidy hindered right siting to private primary care.Conclusions: Financing systems in Singapore, at health policy level, must allow transfer of hospital subsidies to primary care, both private and public, to make it more affordable than hospital care. Structural integration will create a seamless continuum between hospital and primary care.

  5. Dare to Care, Care to Perform

    DEFF Research Database (Denmark)

    Giangreco, Antonio; Sebastiano, Antnio; Carugati, Andrea


    Over the last couple of decades, the modernization of the health sector has been supported by significant investments in IT. Notwithstanding, the results have been often relatively discouraging when compared to other sectors such as banking and insurance. As a consequence, the IT-driven moderniza...... (patients and users), then it will produce positive results for the organization. In other words, who dares to care, will perform.......Over the last couple of decades, the modernization of the health sector has been supported by significant investments in IT. Notwithstanding, the results have been often relatively discouraging when compared to other sectors such as banking and insurance. As a consequence, the IT......-driven modernization literature on the health sector mostly concentrates on the causes of those failures, neglecting therefore the positive experiences. Following the AoM Health Management Track 2008 call for the need of dissemination of best experiences in the health sector, this paper focuses on the IT...

  6. The occurrence of Fusarium culmorum (W. G. Sm.Sacc., Fusarium avenaceum (Fr. Sacc. and Fusarium crookwellense Burgess, Nelson & Toussoun on oats lines (Avena sativa L.

    Directory of Open Access Journals (Sweden)

    Irena Kiecana


    Full Text Available Investigations were carried out in 1996-1998 in the experimental fields in Zamość region. The following ten lines of oats were tested: CHD 894, CHD 1095, CHD 1236, CHD 1607, CHD 1653, CHD 1692, STH 2293, STH 2393, STH 2494, STH 2694. The seedlings which showed symptoms of either root and sheath nectosis, or rotting stems ranged form 9-36 ad 9-70% of all seedlings tested, respectively. Results of mycological analysis of seedlings showed that F.avenaceum and F.culmorum were most frequently represented on infected parts (43% ad 42% of all Fusarium spp. isolates respectively, and also they were the most frequently obtained from stems with necrotic stripes (24% and 46% of all Fusarium spp., respectively. Apart from F.avenaceum and F.culmorum there was some F.crookwellense found every year on lower internodes.

  7. Tombamento de mudas de espécies florestais causado por Sclerotium rolfsii Sacc Damping-off of forest species caused by Sclerotium rolfsii Sacc

    Directory of Open Access Journals (Sweden)

    Reginaldo Gonçalves Mafia


    Full Text Available O estudo objetivou avaliar a gama de hospedeiros de Sclerotium rolfsii por inoculação controlada das seguintes espécies florestais nativas e exóticas: Anadenanthera peregrina (angico-vermelho, Chorisia speciosa (paineira-rosa, Clitoria fairchildiana (sombreiro, Copaifera langsdorffii (copaíba, Delonix regia (flamboyant-vermelho, Enterolobium contortisiliquum (orelha-de-negro, Leucaena leucocephala (leucena, Mabea fistulifera (canudo-de-pito, Platymiscium pubescens (tamboril-da-mata, Senna macranthera (fedegoso, Spathodea campanulata (espatódea e Tabebuia avellanedae (ipê-roxo, bem como comprovar o tombamento de mudas em pré e pós-emergência. Todas as espécies foram suscetíveis ao tombamento de mudas causado por S. rolfsii, em pré e em pós-emergência.The host range of Sclerotium rolfsii was evaluated by controlled inoculation of the following native and exotic forest species: Anadenanthera peregrina (angico vermelho, Chorisia speciosa (paineira rosa, Clitoria fairchildiana (sombreiro, Copaifera langsdorffii (copaíba, Delonix regia (flamboyant vermelho, Enterolobium contortisiliquum (orelha de negro, Leucaena leucocephala (leucena, Mabea fistulifera (canudo-de-pito, Platymiscium pubescens (tamboril da mata, Senna macranthera (fedegoso, Spathodea campanulata (espatódea e Tabebuia avellanedae (ipê roxo. The fungus caused damping-off in pre and post emergence in all tested species.

  8. Achieving Value in Primary Care: The Primary Care Value Model. (United States)

    Rollow, William; Cucchiara, Peter


    The patient-centered medical home (PCMH) model provides a compelling vision for primary care transformation, but studies of its impact have used insufficiently patient-centered metrics with inconsistent results. We propose a framework for defining patient-centered value and a new model for value-based primary care transformation: the primary care value model (PCVM). We advocate for use of patient-centered value when measuring the impact of primary care transformation, recognition, and performance-based payment; for financial support and research and development to better define primary care value-creating activities and their implementation; and for use of the model to support primary care organizations in transformation.

  9. Improving palliative care.

    LENUS (Irish Health Repository)

    Moran, Sue


    Any service improvement project requires planning, action and evaluation. Using a recognised quality improvement framework can offer a structured approach to implementing and assessing changes to patient care. This article describes how use of the Deming Cycle has helped to identify nurses\\' learning needs.

  10. Raising Children Who Care. (United States)

    Kohn, Alfie


    Presents excerpt from Kohn's 1990 book, asserting that parents are most important to children and need to project a positive view of life. Argues that caring, the absence of physical punishment, guiding and explaining, cooperating, and taking children seriously are required to offset the pressure and negative values that a competitive culture…

  11. [Palliative care in neurology]. (United States)

    Provinciali, Leandro; Tarquini, Daniela; De Falco, Fabrizio A; Carlini, Giulia; Zappia, Mario; Toni, Danilo


    Palliative care in neurology is characterized by the need of taking into account some distinguishing features which supplement and often differ from the general palliative approach to cancer or to severe organ failures. Such position is emphasized by a new concept of palliative assistance which is not limited to the "end of life" stage, as it was the traditional one, but is applied along the entire course of progressive, life-limiting, and disabling conditions. There are various reasons accounting for a differentiation of palliative care in neurology and for the development of specific expertise; the long duration of the advanced stages of many neurological diseases and the distinguishing features of some clinical problems (cognitive disorders, psychic disorders, etc.), in addition to the deterioration of some general aspects (nutrition, etc.), make the general criteria adopted for cancer, severe respiratory, hepatic or renal failures and heart failure inadequate. The neurological diseases which could benefit from the development of a specific palliative approach are dementia, cerebrovascular diseases, movement disorders, neuromuscular diseases, severe traumatic brain injury, brain cancers and multiple sclerosis, as well as less frequent conditions. The growing literature on palliative care in neurology provides evidence of the neurological community's increasing interest in taking care of the advanced and terminal stages of nervous system diseases, thus encouraging research, training and updating in such direction. This document aims to underline the specific neurological requirements concerning the palliative assistance.

  12. [Islam and caring]. (United States)

    Nadir, Sihem


    There are more and more followers of the Muslim religion in France. All caregivers need to understand the fundamental principles that their Muslim patients hold sacred in the area of health and care. For Muslims, it is of utmost importance to observe the fundamentals of Islam and the values of brotherhood, tolerance, fairness and truth are essential.

  13. CancerCare (United States)

    ... E-News Blog En Español Facebook Twitter YouTube Instagram LinkedIn National Family Caregivers Month Find resources and ... HOPE (4673) Facebook Twitter YouTube Instagram LinkedIn © 2016 Cancer Care ® — All Rights Reserved Copyright ...

  14. Moral Education and Caring (United States)

    Noddings, Nel


    Michael Slote's very interesting work on moral sentimentalism and moral education raises some important questions on the meaning of empathy, the limitations of "inductions", and the development of moral education from the perspective of care ethics. These questions are addressed in this commentary. (Contains 5 notes.)

  15. Spectator Medical Care. (United States)

    Carlson, L


    Recent world events-including the fear of terrorism during last year's Super Bowl-illustrate how vulnerable spectators can be to medical emergencies during sporting events. A physician who studies and coordinates crowd care for events ranging from the Super Bowl to local fairs gives tips on planning and executing a spectator medical plan.

  16. Care Ethics in Education. (United States)

    Shelby, Candice L.


    Difficulties with current models of ethics education (correct reasoning, virtue theory, directive moral education) include emphasis on reward/punishment and a presumptive bias toward abstract reasoning. Teaching a care-based ethics would promote a fuller notion of mature moral agents and broaden the school climate beyond compliance. (Contains 19…

  17. Introduction to CARE

    CERN Document Server

    Guignard, G


    The main objective of the CARE project is to generate a structured and integrated European area in the field of accelerator research and related R&D. The program includes the most advanced scientific and technological developments relevant to accelerator research for Particle Physics.

  18. Skin Care and Aging (United States)

    ... version of this page please turn Javascript on. Skin Care and Aging How Aging Affects Skin Your skin changes with age. It becomes thinner, ... to make it feel and look better. Dry Skin and Itching Click for more information Many older ...

  19. The Mediatization of Care

    DEFF Research Database (Denmark)

    Dindler, Camilla; Ahlmark, Nanna

    This paper will explore the implications for peer-to-peer health interventions of two developments in modern Western societies; the increasing status of the media as a site for gaining governmental legitimacy (Schillemanns, 2012) and a neoliberal “logic of choice” in health care, focusing on citi...

  20. Epilepsy and oral care. (United States)

    Fiske, Janice; Boyle, Carole


    Epilepsy is a common symptom of an underlying neurological disorder. The seizures can take a variety of forms. Both the condition and its medical management can affect oral health. Prevention of oral disease and carefully planned dental treatment are essential to the well-being of people with epilepsy.

  1. Net4Care platform

    DEFF Research Database (Denmark)


    , that in turn enables general practitioners and clinical staff to view observations. Use the menus above to explore the site's information resources. To get started, follow the short Hello, World! tutorial. The Net4Care project is funded by The Central Denmark Region and EU via Caretech Innovation....

  2. Information in Health Care. (United States)

    Mayeda, Tadashi A.

    The report stresses the fact that while there is unity in the continuum of medicine, information in health care is markedly different from information in medical education and research. This difference is described as an anomaly in that it appears to deviate in excess of normal variation from needs common to research and education. In substance,…

  3. Multidimension Treatment Foster Care

    DEFF Research Database (Denmark)

    Pontoppidan, Maiken; Hansen, Helle; Deding, Mette


    Dette notat er en kort opsamling af den nyeste forskning af effekterne af Multidimension Treatment Foster Care (herefter MTFC). SFI lavede i 2010 en oversigt over forskningen om effekterne af MTFC i forbindelse med udarbejdelsen af en projektbeskrivelse. Dette notat sammenfatter den nyeste...

  4. Caring for Latino patients. (United States)

    Juckett, Gregory


    Latinos comprise nearly 16 percent of the U.S. population, and this proportion is anticipated to increase to 30 percent by 2050. Latinos are a diverse ethnic group that includes many different cultures, races, and nationalities. Barriers to care have resulted in striking disparities in quality of health care for these patients. These barriers include language, lack of insurance, different cultural beliefs, and in some cases, illegal immigration status, mistrust, and illiteracy. The National Standards for Culturally and Linguistically Appropriate Services address these concerns with recommendations for culturally competent care, language services, and organizational support. Latinos have disproportionately higher rates of obesity and diabetes mellitus. Other health problems include stress, neurocysticercosis, and tuberculosis. It is important to explore the use of alternative therapies and belief in traditional folk illnesses, recognizing that health beliefs are dependent on education, socioeconomic status, and degree of acculturation. Many-but not all-folk and herbal treatments can be safely accommodated with conventional therapy. Physicians must be sensitive to Latino cultural values of simpatia (kindness), personalismo (relationship), respeto (respect), and modestia (modesty). The LEARN technique can facilitate cross-cultural interviews. Some cultural barriers may be overcome by using the "teach back" technique to ensure that directions are correctly understood and by creating a welcoming health care environment for Latino patients.

  5. Wound Healing and Care (United States)

    ... wounds can be so different, your doctor will give you instructions on how to take care of yourself after you go home from the hospital. In most cases, doctors will ask patients to do the following ... A doctor or nurse will give you instructions on how to change your dressing ...

  6. Children and chiropractic care

    DEFF Research Database (Denmark)

    Hartvigsen, Jan; Hestbaek, Lise


    care profession has convincingly assumed the responsibility of spinal and musculoskeletal health for children. Considering the magnitude of the challenges ahead for both researchers and clinicians, this may be a good opportunity for doctors of chiropractic to take responsibility and engage...

  7. Shared Oral Care

    DEFF Research Database (Denmark)

    Hede, Børge; Elmelund Poulsen,, Johan; Christophersen, Rasmus


    Shared Oral Care - Forebyggelse af orale sygdomme på plejecentre Introduktion og formål: Mangelfuld mundhygiejne hos plejekrævende ældre er et alment og veldokumenteret sundhedsproblem, der kan føre til massiv udvikling af tandsygdomme, og som yderligere kan være medvirkende årsag til alvorlige...

  8. Shared Care in Diabetes?

    DEFF Research Database (Denmark)

    Bødker, Keld


    The Danish National Board of Health has recently released a report that is intended to mark the start of a new project to establish it support for shared care in diabetes. In this paper I raise a number of concerns where lack of attention towards participation from prospective users constitute...

  9. Animal Care Use Committees. (United States)

    Snyder, Margaret D.; And Others


    Describes the structure, activities, responsibilities, and practices of animal care and use committees established to review classroom activities and student research using animals. Provides six hypothetical situations with suggested solutions to test a committee's decision-making ability. Includes a proposed activity form for teachers. (MDH)

  10. Small Animal Care. (United States)

    Livesey, Dennis W.; Fong, Stephen

    This small animal care course guide is designed for students who will be seeking employment in veterinary hospitals, kennels, grooming shops, pet shops, and small-animal laboratories. The guide begins with an introductory section that gives the educational philosophy of the course, job categories and opportunities, units of instruction required…

  11. Integrating palliative care with usual care of diabetic foot wounds. (United States)

    Dunning, Trisha


    Palliative care is a philosophy and a system for deciding care and can be used alone or integrated with usual chronic disease care. Palliative care encompasses end-of-life care. Palliative care aims to enhance quality of life, optimize function and manage symptoms including early in the course of chronic diseases. The purposes of this article are to outline palliative care and discuss how it can be integrated with usual care of diabetic foot wounds. Many people with diabetes who have foot wounds also have other comorbidities and diabetes complications such as cardiovascular and renal disease and depression, which affect medicine and other treatment choices, functional status, surgical risk and quality of life. Two broad of diabetic foot disease exist: those likely to heal but who could still benefit from integrated palliative care such as managing pain and those where healing is unlikely where palliation can be the primary focus. People with diabetes can die suddenly, although the life course is usually long with periods of stable and unstable disease. Many health professionals are reluctant to discuss palliative care or suggest people to document their end-of-life care preferences. If such preferences are not documented, the person might not achieve their desired death or place of death and health professionals and families can be confronted with difficult decisions. Palliative care can be integrated with usual foot care and is associated with improved function, better quality of life and greater patient and family satisfaction.

  12. A conceptual framework of clinical nursing care in intensive care

    Directory of Open Access Journals (Sweden)

    Rafael Celestino da Silva


    Full Text Available Objective: to propose a conceptual framework for clinical nursing care in intensive care.Method: descriptive and qualitative field research, carried out with 21 nurses from an intensive care unit of a federal public hospital. We conducted semi-structured interviews and thematic and lexical content analysis, supported by Alceste software.Results: the characteristics of clinical intensive care emerge from the specialized knowledge of the interaction, the work context, types of patients and nurses characteristic of the intensive care and care frameworks.Conclusion: the conceptual framework of the clinic's intensive care articulates elements characteristic of the dynamics of this scenario: objective elements regarding technology and attention to equipment and subjective elements related to human interaction, specific of nursing care, countering criticism based on dehumanization.

  13. Lower Costs, Better Care- Reforming Our Health Care Delivery (United States)

    U.S. Department of Health & Human Services — The Affordable Care Act includes tools to improve the quality of health care that can also lower costs for taxpayers and patients. This means avoiding costly...

  14. Primary care patient and provider preferences for diabetes care managers

    Directory of Open Access Journals (Sweden)

    Ramona S DeJesus


    Full Text Available Ramona S DeJesus1, Kristin S Vickers2, Robert J Stroebel1, Stephen S Cha31Division of Primary Care Internal Medicine, Mayo Clinic, Rochester, MN, USA; 2Department of Psychiatry and Psychology, Mayo Clinic, MN, USA; 3Department of Biostatistics, Mayo Clinic, Rochester, MN, USAPurpose: The collaborative care model, using care managers, has been shown to be effective in achieving sustained treatment outcomes in chronic disease management. Little effort has been made to find out patient preferences for chronic disease care, hence, we conducted a study aimed at identifying these.Methods: A 20-item questionnaire, asking for patients’ and providers’ preferences and perceptions, was mailed out to 1000 randomly selected patients in Olmsted County, Minnesota, identified through a diabetes registry to have type 2 diabetes mellitus, a prototypical prevalent chronic disease. Surveys were also sent to 42 primary care providers.Results: There were 254 (25.4% patient responders and 28 (66% provider responders. The majority of patients (>70% and providers (89% expressed willingness to have various aspects of diabetes care managed by a care manager. Although 75% of providers would be comfortable expanding the care manager role to other chronic diseases, only 39.5% of patient responders would be willing to see a care manager for other chronic problems. Longer length of time from initial diagnosis of diabetes was associated with decreased patient likelihood to work with a care manager.Conclusion: Despite study limitations, such as the lack of validated measures to assess perceptions related to care management, our results suggest that patients and providers are willing to collaborate with a care manager and that both groups have similar role expectations of a care manager.Keywords: care manager, collaborative care, patient preference, diabetes care

  15. Disrupted caring attachments: implications for long-term care. (United States)

    Flannery, Raymond B


    Caring attachments or social supports are the positive psychological and physical contacts and relationships between people. These attachments have been associated with improved health, well-being, and longevity. It is also true that disrupted caring attachments are associated with impaired health and well-being. This paper reviews the general medical and elder medical findings of disrupted caring attachments and negative health outcomes. The implications of these findings for dementia sufferers, caregivers, and long-term care staff are examined.

  16. Developing Integrated Care: Towards a development model for integrated care

    NARCIS (Netherlands)

    M.M.N. Minkman (Mirella)


    textabstractThe thesis adresses the phenomenon of integrated care. The implementation of integrated care for patients with a stroke or dementia is studied. Because a generic quality management model for integrated care is lacking, the study works towards building a development model for integrated c

  17. [Assessment of our home care and home palliative care]. (United States)

    Midorikawa, Yasuhiko; Suzushino, Seiko; Tamotsu, Kiyokazu


    We conducted home care and home palliative care from the department of home care. We provided home care services to 190 patients(105 men, 85 women)in October 2013. Their average age was 78.7(range: 32-102)years old, and home care had been underway from 1 day to 8 years, 10 months. Among all participants, 168(88.4%)suffered from malignant diseases, 168 patients had died, and over half of deceased patients(88 out of 168)had died at home. We used opioids for control of cancer pain, carried out home parenteral nutrition(HPN), home enteral nutrition(HEN), percutaneous endoscopic gastrostomy( PEG), and removed pleural effusion and ascites during home care. In order to facilitate the practice of palliative care by the palliative care team, which consists of various medical staff in the hospital, we are giving high priority to education and enlightenment in the hospital. To provide enlightenment, education, and cooperation between regional home care and home palliative care, we are also conducting educational lectures in the regional party of the Iwaki city medical associate, and providing combined educational-medical training for home care and home palliative care by various medical staff.

  18. Affordable Care Act and Women (United States)

    ... Outcomes Research Trust Fund (PCORTF) Poverty Poverty Guidelines Poverty Analysis Teen Pregnancy Prevention Homelessness MACRA Publications Data and Tools Evaluation Database The Affordable Care Act and Women 03/20/2012 Home The Affordable Care Act ...

  19. Your First Prenatal Care Checkup (United States)

    ... report card Careers Archives Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ... Last reviewed: May, 2011 Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ...

  20. MCBS Access to Care PUF (United States)

    U.S. Department of Health & Human Services — The MCBS 2013 Access to Care public use file (MCBS PUF) provides the first publically available MCBS file for researchers interested in the health, health care use,...

  1. Choosing Your Prenatal Care Provider (United States)

    ... on midwives. A family nurse practitioner (also called FNP) is a nurse with special education and training ... care of every member of your family. An FNP can take care of you during pregnancy and ...

  2. Customer care in the NHS. (United States)

    Ruddick, Fred


    Viewing individuals in need of NHS care as customers has the potential to refocus the way their care is delivered. This article highlights some of the benefits of reframing the nurse-patient relationship in terms of customer care, and draws parallels between good customer care and the provision of high quality patient care in the NHS. It explores lessons to be learned from those who have studied the customer experience, which can be adapted to enhance the customer care experience within the health service. Developing professional expertise in the knowledge and skills that underpin good-quality interpersonal encounters is essential to improve the customer experience in health care and should be prioritised alongside the development of more technical skills. Creating a culture where emotional intelligence, caring and compassion are essential requirements for all nursing staff will improve patient satisfaction.

  3. Ensuring Quality Nursing Home Care (United States)

    Ensuring Quality Nursing Home Care Before you choose a nursing home Expert information from Healthcare Professionals Who Specialize in the Care ... Nearly 1.6 million older Americans live in nursing homes in the United States. The move to ...

  4. Taking Care of Your Vision (United States)

    ... of Healthy Breakfasts Shyness Taking Care of Your Vision KidsHealth > For Teens > Taking Care of Your Vision ... are important parts of keeping your peepers perfect. Vision Basics One of the best things you can ...

  5. Center to Advance Palliative Care (United States)

    ... Catalogue Membership Brochure Join CAPC Central Registry National Palliative Care Registry™ Enter your data to improve performance, prove ... Members Only) Identifying the Right Patients for Specialty Palliative Care Webinar Amy Kelley, MD and Arta Bakshandeh, DO, ...

  6. Prenatal Care: Third Trimester Visits (United States)

    Healthy Lifestyle Pregnancy week by week During the third trimester, prenatal care might include vaginal exams to check the baby's ... 2015 Original article: ...

  7. Prenatal Care: Second Trimester Visits (United States)

    Healthy Lifestyle Pregnancy week by week During the second trimester, prenatal care includes routine lab tests and measurements of your ... 2015 Original article: ...

  8. Care and calls

    DEFF Research Database (Denmark)

    Paasch, Bettina Sletten

    This Ph.D. thesis focuses on key aspects of the use of mobile work phones in hospitals. In recent years, demands for efficiency improvements have been predominant in the Danish healthcare system; implementing mobile work phones has been one way of complying with this mandate. Sensitivity...... to and caring for the patient are core values in the nursing profession, and they are grounded in the relationship between nurse and patient. The aim of this thesis is to explore if and how nurses are able to enact care in patient interaction when a mobile work phone also enters the encounter. In studying...... interactions between nurses, patients, and mobile work phones, this thesis draws on several strands of practice theories to alternate between zooming in on the concrete situated actions performed and zooming out on the broader issues that help shape them. The overall theoretical and methodological framework...

  9. Measuring integrated care

    DEFF Research Database (Denmark)

    Strandberg-Larsen, Martin


    Permanente has been put forward as an example for European healthcare systems to follow, although the evidence base is far from conclusive. The thesis has five objectives: 1) To contribute to the understanding of the concept of integration in healthcare systems and to identify measurement methods to capture...... the multi-dimensional aspects of integrated healthcare delivery. 2) To assess the level of integration of the Danish healthcare system. 3) To assess the use of joint health plans as a tool for coordination between the regional and local level in the Danish healthcare system. 4) To compare the inputs...... and performance of the Danish healthcare system and the managed care organization Kaiser Permanente, California, US. 5) To compare primary care clinicians' perception of clinical integration in two healthcare systems: Kaiser Permanente, Northern California and the Danish healthcare system. Further to examine...

  10. Caring Experience and Knowledge

    DEFF Research Database (Denmark)

    Dybbroe, Betina


    A presentation of a case and a theoretical discussion concerning what characterizes the sozialisation and formation taking place in educations related to care work inside the Danish welfare system presently. The article presents an analysis of the relation between curriculum,didactics and educati......A presentation of a case and a theoretical discussion concerning what characterizes the sozialisation and formation taking place in educations related to care work inside the Danish welfare system presently. The article presents an analysis of the relation between curriculum......,didactics and educational thinking- and students experiences and sensing, and illuminates excluding processes in classrooms related to emotional, non-cognitive and relational aspects of the qualifying process. This is set into a larger framework of the biographical professionalization processes of students...

  11. Elderly Care Centre (United States)

    Wagiman, Aliani; Haja Bava Mohidin, Hazrina; Ismail, Alice Sabrina


    The demand for elderly centre has increased tremendously abreast with the world demographic change as the number of senior citizens rose in the 21st century. This has become one of the most crucial problems of today's era. As the world progress into modernity, more and more people are occupied with daily work causing the senior citizens to lose the care that they actually need. This paper seeks to elucidate the best possible design of an elderly care centre with new approach in order to provide the best service for them by analysing their needs and suitable activities that could elevate their quality of life. All these findings will then be incorporated into design solutions so as to enhance the living environment for the elderly especially in Malaysian context.

  12. Reconfiguring Maternity Care?

    DEFF Research Database (Denmark)

    Johannsen, Nis

    This dissertation constitutes a reflection on two initiatives seeking to reconfigure maternity care. One initiative sought to digitalise maternity records and included a pilot run of an electronic maternity record in a Danish county. The other consisted of a collaboration between a maternity ward...... the initiatives were not successful the ambitions remained. To approach the consequences and politics of the proposed changes an experiment is instead carried out. This experiment draws on the interests involved in the initiatives and the three logics, while it constructs a conceptual frame within which three...... experimental designs are constructed. The consequences and the politics of the proposed changes are engaged with in laboratory manner through collaborative development of the designs and through exposing them to members of field of maternity care...

  13. Pediatric cardiac postoperative care

    Directory of Open Access Journals (Sweden)

    Auler Jr. José Otávio Costa


    Full Text Available The Heart Institute of the University of São Paulo, Medical School is a referral center for the treatment of congenital heart diseases of neonates and infants. In the recent years, the excellent surgical results obtained in our institution may be in part due to modern anesthetic care and to postoperative care based on well-structured protocols. The purpose of this article is to review unique aspects of neonate cardiovascular physiology, the impact of extracorporeal circulation on postoperative evolution, and the prescription for pharmacological support of acute cardiac dysfunction based on our cardiac unit protocols. The main causes of low cardiac output after surgical correction of heart congenital disease are reviewed, and methods of treatment and support are proposed as derived from the relevant literature and our protocols.

  14. Palliative care in home care: perceptions of occupational therapists

    Directory of Open Access Journals (Sweden)

    Séfora Gomez Portela


    Full Text Available This research aimed at understanding and reflecting on the perceptions of occupational therapists regarding the implementation of palliative care in home care. This is an exploratory, qualitative study, through semi-structured interviews, conducted in the second semester of 2012 with eight occupational therapists with experience in palliative care in the city of São Paulo. Content analysis identified four themes: characterization and professional trajectory in the field, understanding the concepts of palliative care, home care and palliative care, and occupational therapy and palliative care in home care. The results suggest that the role of the occupational therapist in this field has taken place at different levels of health care, being addressed to people with varying needs. The use of the concept of palliative care by the interviewees exceeds the notion of end of life, following the changes in the epidemiological transition. They understand that professional services follow the trend of national palliative care services with focus on specialized levels, but manifest the importance of its implementation in primary and home care. Among the barriers to practice, they identified the complexity of “being at home “, peculiarities of palliative care with high cost demands, lack of infrastructure and implementation of the current policy. Professional training and scientific roduction in the area were viewed as inadequate, although they identified a call for change. The interviewees recognized palliative care in home care as a strong professional field, but one still requiring study and discussions regarding its limits and conditions of implementation, especially in the Unified Health System.

  15. Health Care Industry (United States)


    Doctor of Osteopathy ) degree and practice general or specialized medicine such as anesthesiology or oncology (IBISWorld, 2006, Offices of Dentists...Carroll, 2003). Complementary and Alternative Medicine includes a wide variety of treatments and therapies that are generally not supported by scientific...correlation between increased health care costs and obesity. According to a 2005 CDC study, “ physical inactivity, overweight, and obesity were associated

  16. [DIE TAKING CARE]. (United States)

    Re, Cecilia


    Under the paradigm of complex thought, Edgar Morin and the pedagogy of the oppressed by Paulo Freire we describe and explain briefly the reasons of the squalid conditions in which develops the work of caring, which is not only an art and a science. The review of scientific literature, as well as the stories of life, support the need for a pedagogical reference change in vocational training programs.

  17. Navy Child Care, 1980. (United States)


    months to 2 1/2 years) full-time. ............. 23.8 Preschool (2 1/2 to 5 years) such as Montessori or other nursery school developmental program...had beyond High School. *Naval Air Station, Miramar One Associate degree, five BA/ES, three Montessori Certified, three enrolled in Montessori training...comes in many forms. The child-care center at Naval Station, Adak, burned in November 1979 (Nida, 1980). Fortunately, there was no loss of life or

  18. Care for Dogs

    Institute of Scientific and Technical Information of China (English)



    <正>I choose dog issue as the starting point of my paper,for I have seen many stray dogs everywhere and also some domestic dogs have no suitable place to live,enjoy little care and have little rights.As to those stray dogs,there are many stray dogs one can see on the street.These dogs are running across roads,sidewalks even highways.Many stray dogs’dead bodies are seen on the

  19. Improving assisted living care. (United States)

    Gregory, Nancy; Gesell, Sabina B; Widmer, Tom


    In the absence of a national measurement system, private vendors of satisfaction measurement and improvement services have played a crucial role in the quality movement in the assisted living industry. Survey responses from 175 resident-family dyads at 20 facilities were analyzed to identify priorities for service improvement from the customers' perspective. They include improving care provided by aides and management, meal service, and activities. Practical solutions for addressing these issues are presented.

  20. Acupuncture in Primary Care



    Acupuncture is an ancient traditional Chinese medical therapy that is used widely around the world. When practiced by a certified provider, it is safe and often perceived as calming and relaxing for patients. Animal and human studies have found a physiological basis for acupuncture needling in that it affects the complex central and peripheral neuro-hormonal network. Although it is unclear whether acupuncture is beneficial over sham/placebo acupuncture, acupuncture care yields clinically rele...

  1. Diabetes Care and Treatment (United States)


    Assessment Tool (BAT) Diabetes mellitus is a significant cause of morbidity and mortality in the United States.1 Clinical and scientific evidence...April. The status of the Chronic Kidney Disease ( CKD ) Clinics was updated. The CKD Clinics are a pilot program for the identification of early...chronic kidney disease patients by primary care providers in the state. Once identified, patients are recruited for enrollment in a CKD where they are

  2. [A theory on care]. (United States)

    Svandra, Philippe


    Trying to define the nature of care when you are a health care professional, means, inevitably, going back to the very source of your professional commitment. Caring, an essential form of responsibility for the other, is thus revealed as a way of behaving towards other people, as an active and concrete commitment testifying as much to the humanity of the one who gives it as to that of the one who receives it. Starting with the notion of the phenomenology of human capacity, Paul Ricoeur thinks of independence in terms of capacity. He calls upon work of the Indian economist Amartya Sen published in the 1980s on the notion of capabilities. This leads to conceiving disease or disability as a lack of elementary or basic capacity. According to Ricoeur, this notion of capacity can only be understood by looking at its contrary: vulnerability. In this way, only a weakened frail person can be called upon to become independent. Thus the human being, and particularly the ill human being, must be looked upon as both vulnerable, and thus suffering, and capable, and thus active.

  3. Telemedicine in wound care. (United States)

    Chanussot-Deprez, Caroline; Contreras-Ruiz, José


    Telemedical wound care is one of the applications of teledermatology. We present our experience using telemedicine in the successful assessment and treatment of three patients with hard-to-heal ulcers. Three patients were seen at the PEMEX General Hospital in Veracruz, Mexico. The first patient was a 53-year-old man with hypertension, morbid obesity, chronic venous insufficiency, recurrent erysipelas, leg ulcers and lymphoedema. There was one ulcer on his left lower leg (20 x 10 cm) and one on his right leg (9 x 7 cm). The second patient was a 73-year-old woman with class III obesity and ulcers in her right leg, secondary to surgical debridement of bullous erysipelas. The third patient was a 51-year-old female with rheumatoid arthritis with one ulcer on each leg and chronic lymphostasis. Photographs with a digital camera were taken and sent weekly via email to a wound care specialist in Mexico City. The photographs allowed the expert to diagnose and evaluate the chronic wounds periodically. In the present cases, telemedicine allowed us to have a rapid evaluation, diagnosis and treatment. The images were of enough quality to be useful and small enough to be sent via regular email to the remote physician who immediately gave his feedback. The expert was confident to give therapeutic recommendations in this way, and we considered this method to be very cost-effective, saving the patient and the health care system, especially in transportation.

  4. Sepsis in critical care. (United States)

    King, Joan E


    Sepsis is a syndrome produced by the accelerated activity of the inflammatory immune response, the clotting cascade, and endothelial damage. It is a systematic process that can progress easily into septic shock and MODS. The chemical mediators or cytokines produce a complex self-perpetuating process that impacts all body systems. It is critical for the nurse first to identify patients at risk for developing sepsis and to assess patients who have SIRS and sepsis continually for signs and symptoms of organ involvement and organ dysfunction. Once sepsis has been diagnosed, evidence-based practice indicates initiation of fluid resuscitation. Vasopressor therapy, positive inotropic support, and appropriate antibiotic therapy should be started within the first hour. Within a 6-hour timeframe the goal is stabilization of the CVP, MAP, and UOP to prevent further organ damage. The challenge for nurses caring for septic patients is to support the treatment goals, to prevent added complications including stress ulcers, DVTs, aspiration pneumonia, and the progression to MODS, and to address the patient's and the family's psychosocial needs. As complex as the pathophysiology of sepsis is, the nursing care is equally complex but also rewarding. Patients who previously might have died now recover as vigilant nursing care combines forces with new drug therapies and evidence-based practice guidelines.

  5. Music in child care

    Directory of Open Access Journals (Sweden)

    Maria Polikandrioti


    Full Text Available Music has been used therapeutically for many centuries, and numerous studies have researched the curative and preventative powers of music in several diseases. Music, as a therapy was shown to have positive effects in child care, such as in premature infants, children in emergency care, children receiving surgery, children in oncology departments and handicapped children. The aim of this review was to study the therapeutic effects of music in child care at hospital. The method οf this study included bibliography research from both the review and the research internatio nal literature, which was referred to the therapeutic effects of music in Children's Hospital. Results: Most studies focus on the beneficial effects of music to child. The results of the study showed that music is widely used to enhance well‐being and appears to exert direct effects to child, which are mainly related to physiology and psychology, including changes in the vital signs, reductions in anxiety and pain, distraction of attention from unpleasant sensations and better communication with the environment at hospital. Furthermore, music exerts indirect effects to child since is able to cause positive modifications in nurses' behaviour and conduces to better performance in their duties. Conclusions: Music consists a low-cost "therapeutic instrument" for nurses to apply to child-patient and is found to be effective in producing positive outcomes. The nurses' knowledge of music therapy need to be improved and the therapeutic impact of music must be a result from systematic professional application.

  6. Accountable Care Units: A Disruptive Innovation in Acute Care Delivery. (United States)

    Castle, Bryan W; Shapiro, Susan E


    Accountable Care Units are a disruptive innovation that has moved care on acute care units from a traditional silo model, in which each discipline works separately from all others, to one in which multiple disciplines work together with patients and their families to move patients safely through their hospital stay. This article describes the "what," "how," and "why" of the Accountable Care Units model as it has evolved in different locations across a single health system and includes the lessons learned as different units and hospitals continue working to implement the model in their complex care environments.

  7. Access and care issues in urban urgent care clinic patients

    Directory of Open Access Journals (Sweden)

    Adams Jill C


    Full Text Available Abstract Background Although primary care should be the cornerstone of medical practice, inappropriate use of urgent care for non-urgent patients is a growing problem that has significant economic and healthcare consequences. The characteristics of patients who choose the urgent care setting, as well as the reasoning behind their decisions, is not well established. The purpose of this study was to determine the motivation behind, and characteristics of, adult patients who choose to access health care in our urgent care clinic. The relevance of understanding the motivation driving this patient population is especially pertinent given recent trends towards universal healthcare and the unclear impact it may have on the demands of urgent care. Methods We conducted a cross-sectional survey of patients seeking care at an urgent care clinic (UCC within a large acute care safety-net urban hospital over a six-week period. Survey data included demographics, social and economic information, reasons that patients chose a UCC, previous primary care exposure, reasons for delaying care, and preventive care needs. Results A total of 1, 006 patients were randomly surveyed. Twenty-five percent of patients identified Spanish as their preferred language. Fifty-four percent of patients reported choosing the UCC due to not having to make an appointment, 51.2% because it was convenient, 43.9% because of same day test results, 42.7% because of ability to get same-day medications and 15.1% because co-payment was not mandatory. Lack of a regular physician was reported by 67.9% of patients and 57.2% lacked a regular source of care. Patients reported delaying access to care for a variety of reasons. Conclusion Despite a common belief that patients seek care in the urgent care setting primarily for economic reasons, this study suggests that patients choose the urgent care setting based largely on convenience and more timely care. This information is especially applicable to

  8. Care seeking for orofacial pain

    NARCIS (Netherlands)

    Rollman, A.; Visscher, C.M.; Gorter, R.C.; Naeije, M.


    AIMS: To determine the contribution of a wide range of factors to care-seeking behavior in orofacial pain patients, expressed as (A) decision to seek care and (B) number of health care practitioners visited. METHODS: Subjects with orofacial pain complaints were recruited in seven TMD clinics and fro

  9. The care perspective and autonomy

    NARCIS (Netherlands)

    Verkerk, M.A.


    In this article I wish to show how care ethics puts forward a fundamental critique on the ideal of independency in human life without thereby discounting autonomy as a moral value altogether. In care ethics, a relational account of autonomy is developed instead. Because care ethics is sometimes crit

  10. Society of Critical Care Medicine (United States)

    ... Critical Care Medicine Podcasts Hosts iCritical Care App Social Media Critical Care Statistics eCommunity Media Relations SmartBrief SCCM App Education Center Annual Congress Program Abstracts Registration and Hotel Exhibits-Sponsorship Sightseeing Activities Past and Future Critical ...

  11. Infant Care Suggestions for Parents (United States)

    ... and a cure, education, awareness, and mutual support. Nurses who work in neonatal intensive care units and nursery departments have experience caring for very small and fragile infants. They can help parents learn the skills and gain confidence necessary to care for their ...

  12. A Universal Duty to Care

    NARCIS (Netherlands)

    I.A.M. Robeyns (Ingrid)


    textabstractThe most basic and fundamental need that human beings have is the need to be properly cared for. Already before their birth, human beings need proper care, for example by being provided with the right nutrition, not being exposed to toxics, and receiving the right professional care to ch


    California State Dept. of Education, Sacramento.


  14. Financing home care in Europe.

    NARCIS (Netherlands)

    Genet, N.; Gulácsi, L.; Boerma, W.; Hutchinson, A.; Garms-Homolova, V.; Naiditch, M.


    Introduction: Financial incentives are widely used to get better value for money. Incentives can be applied to authorities responsible for home care, or to agencies that provide services or to clients who receive care. Details of the financing system of home care services very much determine the pos

  15. Elder Care Comes of Age. (United States)

    Herndon, Mary D.


    A discussion of elder care looks at the extent to which government and employers are addressing the issue, how elder care affects the work performance of and productivity of employed caregivers, and how human resource professionals can respond effectively to the needs of both employee and employer as these needs relate to the issue of elder care.…

  16. Associação entre sintomas de insônia, cochilo diurno e quedas em idosos da comunidade Asociación entre síntomas de insomnio, siesta breve diurna y caídas en ancianos de una comunidad desfavorecida Association between insomnia symptoms, daytime napping, and falls in community-dwelling elderly

    Directory of Open Access Journals (Sweden)

    Anita Liberalesso Neri


    Full Text Available Essa pesquisa investigou associações entre sintomas de insônia, cochilo diurno, e quedas em idosos da comunidade. Estudo transversal de base populacional e amostra probabilística envolvendo 689 idosos da comunidade. O protocolo continha variáveis de autorrelato e de desempenho físico. Foi utilizada a análise de regressão logística univariada e multivariada, e o nível de significância estatística adotado foi de p 80 anos (OR = 3,48; IC95%: 1,54-7,85, cochilo diurno (OR = 2,24; IC95%: 1,24-4,05 e sintomas depressivos (OR = 1,98; IC95%: 1,11-3,53. A associação entre cochilo diurno e quedas replicam dados de pesquisa internacional. Identificar fatores de risco modificáveis pode auxiliar programas de prevenção de quedas.Esta investigación se centró en las asociaciones entre síntomas de insomnio, siesta breve diurna, y caídas en ancianos de una comunidad desfavorecida. Estudio transversal de base poblacional y muestreo probabilístico involucrando a 689 ancianos de una comunidad desfavorecida. El protocolo contenía variables de autorrelato y de desempeño físico. Se utilizó un análisis de regresión logística univariada y multivariada, y el nivel de significancia estadística adoptado fue de p 80 años (OR = 3,48; IC95%: 1,54-7,85, siesta breve diurna (OR = 2,24; IC95%: 1,24-4,05 y síntomas depresivos (OR = 1,98; IC95%: 1,11-3,53. La asociación entre siesta breve diurna y caídas replican datos de investigaciones internacionales. Identificar factores de riesgo modificables pueden auxiliar en programas de prevención de caídas.This study focused on associations between insomnia symptoms, daytime napping, and falls in community-dwelling elderly, using a population-based cross-sectional design and probability sample with 689 community-dwelling elders. The protocol consisted of self-reported and physical performance variables. The study used univariate and multivariate logistic regression analysis with statistical significance

  17. Intensive Care Unit death and factors influencing family satisfaction of Intensive Care Unit care



    Introduction: Family satisfaction of Intensive Care Unit (FS-ICU) care is believed to be associated with ICU survival and ICU outcomes. A review of literature was done to determine factors influencing FS-ICU care in ICU deaths. Results: Factors that positively influenced FS-ICU care were (a) communication: Honesty, accuracy, active listening, emphatic statements, consistency, and clarity; (b) family support: Respect, compassion, courtesy, considering family needs and wishes, and emotional and...

  18. Clinical informatics in critical care. (United States)

    Martich, G Daniel; Waldmann, Carl S; Imhoff, Michael


    Health care information systems have the potential to enable better care of patients in much the same manner as the widespread use of the automobile and telephone did in the early 20th century. The car and phone were rapidly accepted and embraced throughout the world when these breakthroughs occurred. However, the automation of health care with use of computerized information systems has not been as widely accepted and implemented as computer technology use in all other sectors of the global economy. In this article, the authors examine the need, risks, and rewards of clinical informatics in health care as well as its specific relationship to critical care medicine.

  19. Tobacco Dependence: Nursing Care Plans

    Directory of Open Access Journals (Sweden)

    Aurora Miguel García


    Full Text Available Tobacco dependence is a major risk factor for health that requires a correct approach by all health workers. Nursing plays a key role both in identifying smokers, as in the systematic advice to quit smoking, or assist in smoking quit. This work presents three standardized care plans that enable the nursing work in accordance with a methodology and using a standardized language that allows both continuity of care such as research and development of knowledge nurse: Care plan to smoker in precontemplation stage; Care plan to smoker in contemplation stage; Care plan to smoker in preparation/action stage.

  20. Beyond Care Avoidance and Care Paralysis : Theorizing Public Mental Health Care

    NARCIS (Netherlands)

    Schout, Gert; de Jong, Gideon; Zeelen, Jacques


    Care avoidance refers to the condition wherein clients do not seek assistance and do not attend appointments although they are in need of help. Care avoidance is linked to another phenomenon, the inability to help clients with multiple and complex problems by social services and care facilities, in

  1. Concept of Care, Caring Expectations, and Caring Frustrations of the Elderly Suffering from Chronic Illness (United States)

    de Guzman, Allan B.; Santos, Charisse Izobelle Q.; Santos, Ivan Benedict A.; Santos, Jedda A.; Santos, Justin E.; Santos, Justo Martin S.; Santos, Vincent Emmanuelle E.


    While it is true that elderly concepts of care and caring expectations have been ascertained in previous literatures, little is known about how the elderly population views caring frustrations--particularly that of the Filipino elderly. This study purports to surface the lebenswelt of healthcare expectations and frustrations based on the…

  2. Medicaid Managed Care Model of Primary Care and Health Care Management for Individuals with Developmental Disabilities (United States)

    Kastner, Theodore A.; Walsh, Kevin K.


    Lack of sufficient accessible community-based health care services for individuals with developmental disabilities has led to disparities in health outcomes and an overreliance on expensive models of care delivered in hospitals and other safety net or state-subsidized providers. A functioning community-based primary health care model, with an…

  3. Designing robots for care: care centered value-sensitive design. (United States)

    van Wynsberghe, Aimee


    The prospective robots in healthcare intended to be included within the conclave of the nurse-patient relationship--what I refer to as care robots--require rigorous ethical reflection to ensure their design and introduction do not impede the promotion of values and the dignity of patients at such a vulnerable and sensitive time in their lives. The ethical evaluation of care robots requires insight into the values at stake in the healthcare tradition. What's more, given the stage of their development and lack of standards provided by the International Organization for Standardization to guide their development, ethics ought to be included into the design process of such robots. The manner in which this may be accomplished, as presented here, uses the blueprint of the Value-sensitive design approach as a means for creating a framework tailored to care contexts. Using care values as the foundational values to be integrated into a technology and using the elements in care, from the care ethics perspective, as the normative criteria, the resulting approach may be referred to as care centered value-sensitive design. The framework proposed here allows for the ethical evaluation of care robots both retrospectively and prospectively. By evaluating care robots in this way, we may ultimately ask what kind of care we, as a society, want to provide in the future.

  4. Epigenetics and primary care. (United States)

    Wright, Robert; Saul, Robert A


    Epigenetics, the study of functionally relevant chemical modifications to DNA that do not involve a change in the DNA nucleotide sequence, is at the interface between research and clinical medicine. Research on epigenetic marks, which regulate gene expression independently of the underlying genetic code, has dramatically changed our understanding of the interplay between genes and the environment. This interplay alters human biology and developmental trajectories, and can lead to programmed human disease years after the environmental exposure. In addition, epigenetic marks are potentially heritable. In this article, we discuss the underlying concepts of epigenetics and address its current and potential applicability for primary care providers.

  5. Managing as blended care. (United States)

    Mintzberg, H


    As part of a research project on managerial work based on a new model of the roles, the head nurse of a hospital unit was observed during a working day. Her work is described, with reference especially to the roles of leading, linking, controlling, and doing. Conclusions are drawn about the advantages of a craft style of management as opposed to the more traditional "boss" or professional styles. The author also discusses what those in general management can learn from those in nursing management, which seems best practiced out in the open, on one's feet, as a kind of blended care.

  6. Inverted Pyramid of Care. (United States)

    Sonek, Jiri D; Kagan, Karl Oliver; Nicolaides, Kypros H


    First-trimester pregnancy evaluation using fetal and maternal parameters not only allows for diagnoses to be made early in gestation but can also assess the risk of complications that become clinically evident later in pregnancy. This evaluation makes it possible for pregnancy care to be individualized. In select cases, treatment that reduces the risk of complications can be started early in pregnancy. Even though cell free DNA is a significant advance in diagnosing fetal aneuploidy, the combination of first-trimester ultrasound and maternal serum biochemistries casts a much wider diagnostic net; therefore, the 2 technologies are best used in combination.

  7. Betting against health care. (United States)

    Appleby, C


    Health care firms of all types helped fuel the biggest short-selling frenzy in the New York Stock Exchange's history, recently hitting a record 2.2 billion shares. While some analysts say this means nothing, the fact is that many investors are "shorting" the stock; in other words, they're betting against it. What appears as a lack of confidence may be nothing more than a simple quirk of Wall Street. Good, bad or indifferent, selling short is no tall tale.

  8. Health care engineering

    CERN Document Server

    Frize, Monique


    Part II of Health Care Engineering begins with statistics on the occurrence of medical errors and adverse events, and includes some technological solutions. A chapter on electronic medical records follows. The knowledge management process divided into four steps is described; this includes a discussion on data acquisition, storage, and retrieval. The next two chapters discuss the other three steps of the knowledge management process (knowledge discovery, knowledge translation, knowledge integration and sharing). The last chapter briefly discusses usability studies and clinical trials.This two-

  9. Recognition as care

    DEFF Research Database (Denmark)

    Ahlmark, Nanna; Whyte, Susan Reynolds; Harting, Janneke


    This longitudinal study provides critical insight into the social processes of municipal diabetes training for Arabic-speaking immigrants in Denmark focusing on participants’ experiences. Our study builds on observations of three diabetes courses and 36 interviews with participants at the start of......-based and solidarity-based recognition to analyse what was at stake in these experiences, and we engage Annemarie Mol’s concept of a logic of care to show how recognition unfolded practically during the training. We propose that participants’ wider social context and experiences of misrecognition situated the training...

  10. Welfare and self care

    DEFF Research Database (Denmark)

    Gulløv, Eva


    to take care of people’s basic needs but also to enable them to fare well in accordance with the dominant norms of society. This is particularly evident in the case of children. Children are objects of intense normative attention and are invested in as no other social group in order to ensure...... their enculturation. Therefore, studying the collective investments in children, for example by paying attention to the institutional arrangements set up for them, offers insight into dominant cultural priorities and hoped-for outcomes....

  11. Social Public Care Ahead

    Institute of Scientific and Technical Information of China (English)

    Guo Liqin


    @@ China faces toughest after-quake reconstruction since 1976. In contrast with neighbouring Myanmar's lethargic and secre-tive handling of its cyclone ten days earlier, China responded to the earthquake rapidly and with uncharacteristic openness. Within hours Premier Wen Jiabao was on a plane, and appeared in almost all the strategic plac-es in the earthquake-hit areas in the follow-ing days; President Hu Jintao was chairing an emergency meeting of Standing Com-mittee and thousands of soldiers and police were being dispatched. China is moved and moves. For the most impressive time, we read the social care from all works of lives.

  12. Diabetes - taking care of your feet (United States)

    Diabetes - foot care - self-care; Diabetic foot ulcer - foot care; Diabetic neuropathy - foot care ... Diabetes can damage the nerves and blood vessels in your feet. This damage can cause numbness and ...

  13. American Academy of Home Care Medicine (United States)

    ... Newsletter Certification/Training Donate Featured Members Home Care Medicine in America The American Academy of Home Care ... Resources with the American Academy of Home Care Medicine. The American Academy of Home Care Medicine understands ...

  14. Intercultural caring-an abductive model. (United States)

    Wikberg, Anita; Eriksson, Katie


    The aim of this study was to increase the understanding of caring from a transcultural perspective and to develop the first outline of a theory. The theoretical perspective includes Eriksson's theory of caritative caring. Texts on caring by the transcultural theorists, including Campinha-Bacote, Kim-Godwin, Leininger and Ray, are analysed using content analysis. The overall theme that resulted from this analysis was that caring is a complex whole. Three main categories of caring emerged: inner caring, outer caring and the goal of caring. Inner caring consists of caring is a relationship, and caring and culture are seen in different dimensions. Outer caring refers to caring affected by educational, administrative and social and other structures. The goal of caring consists of caring leading to change towards health and well-being. The main categories include categories and subcategories that are compared with Eriksson's theory of caritative caring. A model for intercultural caring is generated abductively. Caring and culture appear in three dimensions: caring as ontology independent of context; caring as a phenomenon emphasised differently in different cultures; caring as nursing care activities is unique. Caring alleviates suffering and leads to health and well-being. This model describes caring from an intercultural perspective as a mutual but asymmetric relationship between the nurse and the patient, including the patient's family and community. The patient's cultural background and acculturation influence caring. The cultural background, cultural competence and organisation of the nurse also influence caring. Caring is seen as a complex whole. This study integrates Campinha-Bacote's, Kim-Godwin's, Leininger's and Ray's views of caring with Eriksson's caritative caring and presents caring from a transcultural perspective in a new way as a model for intercultural caring, which can benefit nursing care, education, research and administration.

  15. Reforming the health care system: implications for health care marketers. (United States)

    Petrochuk, M A; Javalgi, R G


    Health care reform has become the dominant domestic policy issue in the United States. President Clinton, and the Democratic leaders in the House and Senate have all proposed legislation to reform the system. Regardless of the plan which is ultimately enacted, health care delivery will be radically changed. Health care marketers, given their perspective, have a unique opportunity to ensure their own institutions' success. Organizational, managerial, and marketing strategies can be employed to deal with the changes which will occur. Marketers can utilize personal strategies to remain proactive and successful during an era of health care reform. As outlined in this article, responding to the health care reform changes requires strategic urgency and action. However, the strategies proposed are practical regardless of the version of health care reform legislation which is ultimately enacted.

  16. Symptom management in palliative care and end of life care. (United States)

    Bookbinder, Marilyn; McHugh, Marlene E


    There is a need for generalist- and specialist-level palliative care clinicians proficient in symptom management and care coordination. Major factors contributing to this need include changed disease processes and trajectories, improved medical techniques and diagnostic testing, successful screening for chronic conditions, and drugs that often prolong life. The rapid progressive illnesses and deaths that plagued the first half of the twentieth century have been replaced in the twenty-first century by increased survival rates. Conditions that require ongoing medical care beyond a year define the current chronic illness population. Long years of survival are often accompanied by a reduced quality of life that requires more medical and nursing care and longer home care. This article reviews the management of selected symptoms in palliative and end of life care.

  17. Why do care workers withdraw from elderly care?

    DEFF Research Database (Denmark)

    Liveng, Anne


    . At the same time it illustrates the care workers' commitment to the elderly. A paradoxical "empathy at a distance" is characteristic of the scene. When analyzing my written observations in an interpretation group, my use of language was a point of discussion. What did it mean when I described the interactions...... between care workers and elderly residents in words commonly used to describe mother-child interactions? My use of language became a "hermeneutical key" which enabled a psychoanalytically inspired interpretation. This focuses on the care relationship as activating our earliest memories of our own care....... The article illustrates how working consciously with the researcher's subjectivity makes it possible to understand apparently irrational patterns. The insights thus gained may be used to prevent withdrawals in care work as an argument for care workers' need for emotional supervision....

  18. [Family oriented nursing care]. (United States)

    Lima-Rodríguez, Joaquin Salvador; Lima-Serrano, Marta; Sáez-Bueno, Africa


    Nursing has experienced an important methodological development, in which it gives priority to the individual, although at a socioeconomic level a marked interest is seen in the health care of the family unit and the NANDA (North American Nursing Diagnosis Association), NIC (Nursing Interventions Classification) and NOC (Nursing Outcomes Classification) nursing guidelines, using diagnoses, criteria of results and interventions orientated towards this aim. We consider to the family as an opened system consisted of human elements, with a common history, which they form a functional unit been ruled by own procedure. In this paper we look at those aspects that must be taken into account in nursing assessment of families from a systemic perspective, including some tools for data collection and analysis of information. In addition, we identify specific areas of intervention. We believe that the family must be studied from a nursing care point of view with its own characteristics as opposed to those possessed individually by each of its members. We also believe that, when assessment is centred on the Henderson unaided activities study or the Gordon functional health patterns, they are not useful in assessing the family unit. This work offers an assessment method centred on the family unit, which helps to identify the nursing diagnoses applicable to it. Our proposal, which has been successfully used by nursing students over the last few years, hopes to contribute to quality clinical practice with a tool orientated towards the family.

  19. Measuring integrated care. (United States)

    Strandberg-Larsen, Martin


    The positive outcomes of coordination of healthcare services are to an increasing extent becoming clear. However the complexity of the field is an inhibiting factor for vigorously designed trial studies. Conceptual clarity and a consistent theoretical frame-work are thus needed. While researchers respond to these needs, patients and providers face the multiple challenges of today's healthcare environment. Decision makers, planners and managers need evidence based policy options and information on the scope of the integrated care challenges they are facing. The US managed care organization Kaiser Permanente has been put forward as an example for European healthcare systems to follow, although the evidence base is far from conclusive. The thesis has five objectives: 1) To contribute to the understanding of the concept of integration in healthcare systems and to identify measurement methods to capture the multi-dimensional aspects of integrated healthcare delivery. 2) To assess the level of integration of the Danish healthcare system. 3) To assess the use of joint health plans as a tool for coordination between the regional and local level in the Danish healthcare system. 4) To compare the inputs and performance of the Danish healthcare system and the managed care organization Kaiser Permanente, California, US. 5) To compare primary care clinicians' perception of clinical integration in two healthcare systems: Kaiser Permanente, Northern California and the Danish healthcare system. Further to examine the associations between specific organizational factors and clinical integration within each system. The literature was systematically searched to identify methods for measurement of integrated healthcare delivery. A national cross-sectional survey was conducted among major professional stake-holders at five different levels of the Danish healthcare system. The survey data were used to allow for analysis of the level of integration achieved. Data from the survey were

  20. Managing acute care. (United States)

    Russell, J S


    In the last few years, much medical-facility construction has been driven by what insurers want. Hospitals have built facilities for well-reimbursed procedures and closed money-losing ones. Health-maintenance organizations increasingly expect to hold down costs by making prepayment arrangements with doctors and their hospitals. President Clinton has pledged early action on health-care reform, which will likely change planners' priorities. Whether the nation goes to Clintonian "managed competition" or a Canadian-style nationwide single-payer system (the two most likely options), the projects on these pages reflect two large-scale trends that are likely to continue: the movement of more procedures from inpatient to outpatient facilities and the separation of treatment functions from ordinary office and administrative tasks so that the latter are not performed in the same high-cost buildings as technology-intensive procedures. Various schemes that make care more "patient-centered" have been tried and been shown to speed healing, even for outpatients, but such hard-to-quantify issues get short shrift in an era of knee-jerk cost containment. The challenge in tomorrow's healthcare universe--whatever it becomes--will be to keep these issues on the table.

  1. Flourishing in Health Care. (United States)

    Edgar, Andrew; Pattison, Stephen


    The purpose of this paper is to offer an account of 'flourishing' that is relevant to health care provision, both in terms of the flourishing of the individual patient and carer, and in terms of the flourishing of the caring institution. It is argued that, unlike related concepts such as 'happiness', 'well-being' or 'quality of life', 'flourishing' uniquely has the power to capture the importance of the vulnerability of human being. Drawing on the likes of Heidegger and Nussbaum, it is argued that humans are at once beings who are autonomous and thereby capable of making sense of their lives, but also subject to the contingencies of their bodies and environments. To flourish requires that one engages, imaginatively and creatively, with those contingencies. The experience of illness, highlighting the vulnerability of the human being, thereby becomes an important experience, stimulating reflection in order to make sense of one's life as a narrative. To flourish, it is argued, is to tell a story of one's life, realistically engaging with vulnerability and suffering, and thus creating a framework through which one can meaningful and constructively go on with one's life.

  2. Green Care Farms

    Directory of Open Access Journals (Sweden)

    Simone R. de Bruin PhD


    Full Text Available Objective: To explore the value of day services at green care farms (GCFs in terms of social participation for people with dementia. Method: Semi-structured interviews were conducted with people with dementia who attended day services at a GCF (GCF group, n = 21, were on a waiting list (WL for day services at a GCF (WL group, n = 12, or attended day services in a regular day care facility (RDCF group, n = 17 and with their family caregivers. Results: People with dementia in the GCF and WL group were primarily males, with an average age of 71 and 76 years, respectively, who almost all had a spousal caregiver. People with dementia in the RDCF group were mostly females with an average age of 85 years, most of whom had a non-spousal caregiver. For both the GCF and RDCF groups, it was indicated that day services made people with dementia feel part of society. The most important domains of social participation addressed by RDCFs were social interactions and recreational activities. GCFs additionally addressed the domains “paid employment” and “volunteer work.” Conclusion: GCFs are valuable in terms of social participation for a particular group of people with dementia. Matching characteristics of adult day services (ADS centers to the preferences and capacities of people with dementia is of importance. Diversity in ADS centers is therefore desirable.

  3. Critical issues in burn care. (United States)

    Holmes, James H


    Burn care, especially for serious burn injuries, represents a considerable challenge for the healthcare system. The American Burn Association has established a number of strategies for the management of burn patients and dedicates its efforts and resources to promoting and supporting burn-related research, education, care, rehabilitation, and prevention, often in collaboration with other organizations. The American Burn Association has recommended that patients with serious burns be referred to a designated burn center, ie, a hospital outfitted with specialized personnel and equipment dedicated to burn care. Burn centers have been operational for over 50 years, but the complexity and costs of providing specialized burn care have given rise to a number of critical administrative and political issues. These include logistical limitations imposed by the uneven national distribution of burn centers and a potential shortage of burn beds, both during everyday conditions and in the event of a mass disaster. Burn surgeon shortages have also been identified, stemming, in part, from a lack of specialized burn care training opportunities. There is currently a lack of quality outcome data to support evidence-based recommendations for burn care, and burn care centers are compromised by problems obtaining reimbursement for the care of uninsured and publicly insured out-of-state burn patients. Initiatives are underway to maintain efficient burn care facilities that are fully funded, easily accessible, and most importantly, provide optimal, evidence-based care on a daily basis, and are well-equipped to handle a surge of patients during a disaster situation.

  4. Integrating Care in Complex Cardiac Care: the Tech Touch


    Stellato, Kira; Radini, Donatella; Pellizzari, Mara; Pordenon, Marta; Pletti, Luciano; Humar, Franco; Apuzzo, Matteo; Fragiacomo, Emanuela; Delli Quadri, Nicola; Di Lenarda, Andrea


    Background: The ageing of European population and the steady increasing of complex chronic disease pose substantial challenges to the sustainability of health and social care services and to the quality of life of European citizens . The testing of new frontiers of eCare for outpatient domiciliary monitoring of elderly citizens is essential in order to assess efficacy and sustainability of new technologies for integrated care, including telehealth and telemonitoring platforms. Friuli-Venezia ...

  5. Palliative Care as a Standard of Care in Pediatric Oncology. (United States)

    Weaver, Meaghann S; Heinze, Katherine E; Kelly, Katherine P; Wiener, Lori; Casey, Robert L; Bell, Cynthia J; Wolfe, Joanne; Garee, Amy M; Watson, Anne; Hinds, Pamela S


    The study team conducted a systematic review of pediatric and adolescent palliative cancer care literature from 1995 to 2015 using four databases to inform development of a palliative care psychosocial standard. A total of 209 papers were reviewed with inclusion of 73 papers for final synthesis. Revealed topics of urgent consideration include the following: symptom assessment and intervention, direct patient report, effective communication, and shared decision-making. Standardization of palliative care assessments and interventions in pediatric oncology has the potential to foster improved quality of care across the cancer trajectory for children and adolescents with cancer and their family members.

  6. Diabetes care provision in UK primary care practices.

    Directory of Open Access Journals (Sweden)

    Gillian Hawthorne

    Full Text Available BACKGROUND: Although most people with Type 2 diabetes receive their diabetes care in primary care, only a limited amount is known about the quality of diabetes care in this setting. We investigated the provision and receipt of diabetes care delivered in UK primary care. METHODS: Postal surveys with all healthcare professionals and a random sample of 100 patients with Type 2 diabetes from 99 UK primary care practices. RESULTS: 326/361 (90.3% doctors, 163/186 (87.6% nurses and 3591 patients (41.8% returned a questionnaire. Clinicians reported giving advice about lifestyle behaviours (e.g. 88% would routinely advise about calorie restriction; 99.6% about increasing exercise more often than patients reported having received it (43% and 42% and correlations between clinician and patient report were low. Patients' reported levels of confidence about managing their diabetes were moderately high; a median (range of 21% (3% to 39% of patients reporting being not confident about various areas of diabetes self-management. CONCLUSIONS: Primary care practices have organisational structures in place and are, as judged by routine quality indicators, delivering high quality care. There remain evidence-practice gaps in the care provided and in the self confidence that patients have for key aspects of self management and further research is needed to address these issues. Future research should use robust designs and appropriately designed studies to investigate how best to improve this situation.

  7. Critical Care Glucose Point-of-Care Testing. (United States)

    Narla, S N; Jones, M; Hermayer, K L; Zhu, Y

    Maintaining blood glucose concentration within an acceptable range is a goal for patients with diabetes mellitus. Point-of-care glucose meters initially designed for home self-monitoring in patients with diabetes have been widely used in the hospital settings because of ease of use and quick reporting of blood glucose information. They are not only utilized for the general inpatient population but also for critically ill patients. Many factors affect the accuracy of point-of-care glucose testing, particularly in critical care settings. Inaccurate blood glucose information can result in unsafe insulin delivery which causes poor glucose control and can be fatal. Healthcare professionals should be aware of the limitations of point-of-care glucose testing. This chapter will first introduce glucose regulation in diabetes mellitus, hyperglycemia/hypoglycemia in the intensive care unit, importance of glucose control in critical care patients, and pathophysiological variables of critically ill patients that affect the accuracy of point-of-care glucose testing. Then, we will discuss currently available point-of-care glucose meters and preanalytical, analytical, and postanalytical sources of variation and error in point-of-care glucose testing.

  8. Can health care teams improve primary care practice? (United States)

    Grumbach, Kevin; Bodenheimer, Thomas


    In health care settings, individuals from different disciplines come together to care for patients. Although these groups of health care personnel are generally called teams, they need to earn true team status by demonstrating teamwork. Developing health care teams requires attention to 2 central questions: who is on the team and how do team members work together? This article chiefly focuses on the second question. Cohesive health care teams have 5 key characteristics: clear goals with measurable outcomes, clinical and administrative systems, division of labor, training of all team members, and effective communication. Two organizations are described that demonstrate these components: a private primary care practice in Bangor, Me, and Kaiser Permanente's Georgia region primary care sites. Research on patient care teams suggests that teams with greater cohesiveness are associated with better clinical outcome measures and higher patient satisfaction. In addition, medical settings in which physicians and nonphysician professionals work together as teams can demonstrate improved patient outcomes. A number of barriers to team formation exist, chiefly related to the challenges of human relationships and personalities. Taking small steps toward team development may improve the work environment in primary care practices.

  9. [Social inequality in home care]. (United States)

    Möller, A; Osterfeld, A; Büscher, A


    Social inequality in Germany is discussed primarily with regard to educational or social welfare issues. There is a political consensus that more action should be taken to ensure equality of chances and fulfillment of basic needs for everyone. In long-term care these considerations have not yet taken place and there are hardly any research studies in this field. However, the startling rise of the need for long-term care will definitely require a discussion of social inequality in various care arrangements. To learn more about social inequality in home care, a qualitative approach was used and 16 home care nurses were interviewed. Our study shows that many care recipients face numerous problems they cannot handle on their own, which may even worsen their situation. In addition, the results reveal that facing social inequalities place a burden on nurses and influence their work performance.

  10. Generalist palliative care in hospital

    DEFF Research Database (Denmark)

    Bergenholtz, Heidi; Jarlbæk, Lene; Hølge-Hazelton, Bibi


    Background: It can be challenging to provide generalist palliative care in hospitals, owing to difficulties in integrating disease-orientedtreatment with palliative care and the influences of cultural and organisational conditions. However, knowledge on the interactionsthat occur is sparse. Aim......: a quantitative study, in whichthree independent datasets were triangulated to study the organisation and evaluation of generalist palliative care, and a qualitative,ethnographic study exploring the culture of generalist palliative nursing care in medical departments. Setting/participants: A Danish regional......: To investigate the interactions between organisation and culture as conditions for integrated palliative care in hospital and, ifpossible, to suggest workable solutions for the provision of generalist palliative care. Design: A convergent parallel mixed-methods design was chosen using two independent studies...

  11. Rawlsian Justice and Palliative Care

    DEFF Research Database (Denmark)

    Knight, Carl; Albertsen, Andreas


    Palliative care serves both as an integrated part of treatment and as a last effort to care for those we cannot cure. The extent to which palliative care should be provided and our reasons for doing so have been curiously overlooked in the debate about distributive justice in health and healthcare....... We argue that one prominent approach, the Rawlsian approach developed by Norman Daniels, is unable to provide such reasons and such care. This is because of a central feature in Daniels' account, namely that care should be provided to restore people's opportunities. Daniels' view is both unable...... to provide pain relief to those who need it as a supplement to treatment and, without justice-based reasons to provide palliative care to those whose opportunities cannot be restored. We conclude that this makes Daniels' framework much less attractive....

  12. Inter-Professional Palliative Care

    DEFF Research Database (Denmark)

    Madsen, Kirsten Halskov; Henriksen, Jette; Meldgaard, Anette


    Chapter 11 by Kirsten Halskov Madsen, Anette Meldgaard and Jette Henriksen deals with the development of palliative care programmes aimed at the basic level of palliative care practice. The need to develop educational opportunities at particularly this level – described as ‘the basic inter......-professional level of palliative care’ – has been increasing for many years where palliative care has conventionally and primarily been associated with specialist training. As the authors show – based on a mapping out of existing educational initiatives in a region of Denmark, a reading of the curriculum...... and a description of the organization of palliative care – there is a need for such inter-professional palliative care that raises the level of competences at the basic level and the sharing of knowledge as well as securing the continuous qualifying of healthcare staff working with palliative care....

  13. Teamwork in obstetric critical care


    Guise, Jeanne-Marie; Segel, Sally


    Whether seeing a patient in the ambulatory clinic environment, performing a delivery or managing a critically ill patient, obstetric care is a team activity. Failures in teamwork and communication are among the leading causes of adverse obstetric events, accounting for over 70% of sentinel events according to the Joint Commission. Effective, efficient and safe care requires good teamwork. Although nurses, doctors and healthcare staff who work in critical care environments are extremely well t...

  14. Controversies in neurosciences critical care. (United States)

    Chang, Tiffany R; Naval, Neeraj S; Carhuapoma, J Ricardo


    Neurocritical care is an evolving subspecialty with many controversial topics. The focus of this review is (1) transfusion thresholds in patients with acute intracranial bleeding, including packed red blood cell transfusion, platelet transfusion, and reversal of coagulopathy; (2) indications for seizure prophylaxis and choice of antiepileptic agent; and (3) the role of specialized neurocritical care units and specialists in the care of critically ill neurology and neurosurgery patients.

  15. Critical Care of Pet Birds. (United States)

    Jenkins, Jeffrey Rowe


    Successful care of the critical pet bird patient is dependent on preparation and planning and begins with the veterinarian and hospital staff. An understanding of avian physiology and pathophysiology is key. Physical preparation of the hospital or clinic includes proper equipment and understanding of the procedures necessary to provide therapeutic and supportive care to the avian patient. An overview of patient intake and assessment, intensive care environment, and fluid therapy is included.

  16. Adolf Hitler's medical care. (United States)

    Doyle, D


    For the last nine years of his life Adolf Hitler, a lifelong hypochondriac had as his physician Dr Theodor Morell. Hitler's mood swings, Parkinson's disease, gastro-intestinal symptoms, skin problems and steady decline until his suicide in 1945 are documented by reliable observers and historians, and in Morell's diaries. The bizarre and unorthodox medications given to Hitler, often for undisclosed reasons, include topical cocaine, injected amphetamines, glucose, testosterone, estradiol, and corticosteroids. In addition, he was given a preparation made from a gun cleaner, a compound of strychnine and atropine, an extract of seminal vesicles, and numerous vitamins and 'tonics'. It seems possible that some of Hitler's behaviour, illnesses and suffering can be attributed to his medical care. Whether he blindly accepted such unorthodox medications or demanded them is unclear.

  17. Primary care guidelines

    DEFF Research Database (Denmark)

    Ijäs, Jarja; Alanen, Seija; Kaila, Minna


    OBJECTIVE: To describe the adoption of the national Hypertension Guideline in primary care and to evaluate the consistency of the views of the health centre senior executives on the guideline's impact on clinical practices in the treatment of hypertension in their health centres. DESIGN: A cross...... Guideline. RESULTS: Data were available from 143 health centres in Finland (49%). The views of head physicians and senior nursing officers on the adoption of the Hypertension Guideline were not consistent. Head physicians more often than senior nursing officers (44% vs. 29%, p ...: Hypertension Guideline recommendations that require joint agreements between professionals are less often adopted than simple, precise recommendations. More emphasis on effective multidisciplinary collaboration is needed....

  18. Federalism and Health Care

    Directory of Open Access Journals (Sweden)

    G. Alan Tarr


    Full Text Available President Barack Obama proposed a major overhaul of the American healthsystem, and in 2010 the U.S. Congress enacted his proposal, the PatientProtection and Affordable Care Act. Opponents of the Act challenged itsconstitutionality in federal court, claiming that it exceeds the powers grantedto the federal government under the Commerce Clause and the NecessaryProper Clause of the federal Constitution. Some courts have upheldthe law, but others have agreed with the critics, in particular ruling thatthe provision requiring citizens to buy health insurance is unconstitutional.Eventually the U.S. Supreme Court will rule on the issue. This article tracesthe controversy, surveys the interpretation of pertinent constitutional provisionsin past cases, analyzes the constitutional arguments presented byproponents and opponents of the Act, and concludes that the Act is constitutional.

  19. Vulvovaginal hygiene and care

    Directory of Open Access Journals (Sweden)

    Gupte Pushpa


    Full Text Available Homeostasis of the skin is very important, which is achieved by a thin acid film - the acid mantle. Human skin has an acid mantle of pH 4-6. It prevents invasion by pathogenic organisms, acting as a first-line defence and helping in a disease-free existence. The vaginal mucosa has a similar acid mantle. Here, the natural acidic pH is maintained by lactic acid, an integral part of the vaginal ecosystem. This can be easily lost due to the lack of awareness of local care or various aggressive hygiene practices in addition to various diseases. Gentle cleansing along with good moisturization can go a long way in keeping the vulva healthy.

  20. Accountability in Health Care

    DEFF Research Database (Denmark)

    Vrangbæk, Karsten; Byrkjeflot, Haldor


    The debate on accountability within the public sector has been lively in the past decade. Significant progress has been made in developing conceptual frameworks and typologies for characterizing different features and functions of accountability. However, there is a lack of sector specific...... adjustment of such frameworks. In this article we present a framework for analyzing accountability within health care. The paper makes use of the concept of "accountability regime" to signify the combination of different accountability forms, directions and functions at any given point in time. We show...... that reforms can introduce new forms of accountability, change existing accountability relations or change the relative importance of different accountability forms. They may also change the dominant direction and shift the balance between different functions of accountability. We further suggest...

  1. Team networking in palliative care

    Directory of Open Access Journals (Sweden)

    Odette Spruyt


    Full Text Available "If you want to travel quickly, go alone. But if you want to travel far, you must go together". African proverb. The delivery of palliative care is often complex and always involves a group of people, the team, gathered around the patient and those who are close to them. Effective communication and functional responsive systems of care are essential if palliative care is to be delivered in a timely and competent way. Creating and fostering an effective team is one of the greatest challenges for providers of palliative care. Teams are organic and can be life giving or life sapping for their members.

  2. Culture, palliative care and multiculturalism. (United States)

    Nyatanga, Brian


    The frequently asked question, 'Why do minority ethnic groups not access palliative care?' needs closer analysis. This article sets out to revisit the context and principles of palliative care and discuss why palliative care services are not accessed equally by all cultural groups in western, particularly UK, society. The conceptual basis of culture, together with cultural diversity, will be discussed to foster greater understanding of multiculturalism with a view to offering recommendations for the provision of culturally sensitive palliative care. These recommendations will seek to be challenging but realistic, both for practitioners providing such care and for educationalist disseminating 'knowledge'. I will highlight what I believe are the challenges of providing palliative care that is acceptable to minority ethnic groups based on personal experience and literature, and emphasize that these challenges should be seen as potential opportunities. It is hoped that this article will set a platform for honest and open discussion about the way forward in providing culturally sensitive palliative care for minority ethic groups. I will pose a challenging call to all members of minority ethnic groups to adopt a more proactive approach to their own care by preparing themselves to be in an influential position in palliative care provision through academic and clinical endeavours.

  3. Gestational diabetes - self-care (United States)

    Pregnancy - gestational diabetes; Prenatal care - gestational diabetes ... Gestational diabetes is high blood sugar (glucose) that happens during pregnancy. There are no symptoms in most cases. But ...

  4. Caring for children with ostomies. (United States)

    Garvin, G


    Caring for children with ostomies comprehensively requires that the healthcare professional understand issues related to normal growth and development as well as more specific medical information about disease processes and ostomy care. Parents should have a working knowledge of routine ostomy care and need guidelines to assist them in recognizing ostomy complications. Complications range from mild to severe. Many patients will experience at least one ostomy-related complication during the time they have their diversion. Active support of the child and the parent is essential toward facilitating acceptance and integration of ostomy care in pediatric ostomy clients.

  5. Foster Care and Child Health. (United States)

    McDavid, Lolita M


    Children in foster care need more from health providers than routine well-child care. The changes in legislation that were designed to prevent children from languishing in foster care also necessitate a plan that works with the child, the biological family, and the foster family in ensuring the best outcome for the child. This approach acknowledges that most foster children will return to the biological family. Recent research on the effect of adverse childhood experiences across all socioeconomic categories points to the need for specifically designed, focused, and coordinated health and mental health services for children in foster care.

  6. Diaspora, disease, and health care. (United States)

    Wick, Jeannette Y; Zanni, Guido R


    When groups of people relocate from their homelands to other nations, especially if the movement is involuntary, minority populations are created in the countries that receive them. The issues related to these diaspora and diasporic communities--any groups that have been dispersed outside their traditional homelands--are financial, social, historical, political, or religious. In health care, issues include heritable diseases, cultural barriers, patients' health care beliefs, and unique disease presentations. In long-term care, many residents and health care providers have relocated to the United States from other countries.

  7. Monitoring Technology Meets Care Work

    DEFF Research Database (Denmark)

    Kanstrup, Anne Marie; Bygholm, Ann


    Monitoring technology, especially sensor-based technology, is increasingly taken into use in care work. Despite the simplicity of these technologies – aimed to automate what appear as mundane monitoring tasks – recent research has identified major challenges primarily related to the technology......'s ability to meet the complexity of care work. Understanding intersectional challenges between these care technologies and care work is fundamental to improve design and use of health informatics. In this paper we present an analysis of interaction challenges between a wet-sensor at the task of monitoring...

  8. No end to caring? (United States)

    Robison, Shea


    In a recent issue of Politics and the Life Sciences Mark Walker presented a compelling proposition for reducing evil in the world via an interdisciplinary program he calls the "Genetic Virtue Project" (GVP). As Walker explains, the purpose of the GVP is "to discover and enhance human ethics using biotechnology genetic correlates of virtuous behavior." PLS subsequently published several critiques of this proposal. While most of these critiques focused on conventional doubts about the technical feasibility or the ethics of such interventions, the more fundamental concern revealed by both Walker's proposal and its critiques is in the largely unquestioned assumption that more morality is necessarily better. Human history is marked by a gradual if uneven extension of moral concern to increasingly distant others, which many take as evidence of the rationality of morality. There is substantial evidence, though, that this expansion is fundamentally biological in origin and therefore not ultimately limited by rationality. Because these expanding moral feelings feel so good to us, we are incapable of perceiving the danger from their ever-expanding focus, in particular from the sincere but increasingly maladaptive collective policies they will engender. Utilizing the philosophy of Friedrich Nietzsche as a platform, the feasibility of different natural and cultural responses to this impending crisis of caring are examined, none of which are found capable of counteracting this expanding morality. Instead, the best hope for a successful response to this dangerous expansion of caring is actually a sort of reverse GVP, in which the biological mechanisms for this unchecked moral expansion are manipulated via genetic engineering to dial back this expansion. However, the likelihood of actually implementing such an admittedly counterintuitive and controversial program within an increasingly democratized world is doubtful. Ultimately, if we are unable to overcome this betrayal by our

  9. What Is the Essence of Spiritual Care?

    DEFF Research Database (Denmark)

    Steenfeldt, Vibeke Østergaard


    This study explored patient, relatives, and healthcare professionals’ experience of life and caring practice in two Danish hospice settings. Using a phenomenological approach, four caring themes emerged from data analysis: Recognized as an individual human being; Caring as doing and being; Caring...... for the whole body; and Spaces of caring. Spiritual care was understood as providing whole body experiences, respecting the patient, and involving the other person.......This study explored patient, relatives, and healthcare professionals’ experience of life and caring practice in two Danish hospice settings. Using a phenomenological approach, four caring themes emerged from data analysis: Recognized as an individual human being; Caring as doing and being; Caring...

  10. Attitudes of Nonpalliative Care Nurses towards Palliative Care

    Directory of Open Access Journals (Sweden)

    Victoria Tait


    Full Text Available The quality of palliative care given to terminally ill patients and their family members can be directly impacted by the attitudes that nurses hold towards palliative care. This study aimed to investigate the attitudes of nonpalliative care nurses towards death and dying in the context of palliative care. Nurses working within the medical aged care, cardiology and respiratory wards at two metropolitan teaching hospitals in Sydney completed the Frommelt Attitudes Towards Care of the Dying (FATCOD scale, an anonymous self-administered questionnaire, and a twelve-item demographic questionnaire. A total of 95 completed surveys were used in the final analysis. The total FATCOD score was 119.8±11.1, patient FATCOD was 79.6±8.6, and family FATCOD was 40.2±4.4. Of significance, the professional variables designation and role were associated with attitudes in the total FATCOD and country of birth, designation, highest level of education, and role were associated with attitudes towards the patient FATCOD. Scores for communication between the nurse and the terminally ill patient were poor. Health care facilities should focus on developing strategies to improve the communication skills among nonpalliative care nurses in order to optimize patient outcomes.

  11. Zoning for Day Care (from Models for Day Care Licensing). (United States)

    Day Care and Child Development Council of America, Inc., Washington, DC.

    Recommendations and regulations regarding the zoning of child development day care programs are discussed. Zoning in general is discussed, as is the treatment of child development day care in zoning ordinance, the background of program planning, modular housing, the impelmentation of zoning, and model provisions regarding characteristics of…

  12. Caring for the Environment: Challenges from Notions of Caring (United States)

    Martin, Peter


    In 2003 John Fien presented an argument for environmental education to encompass deep and wide caring for human and nonhuman nature (Fien, 2003). His philosophical discussion of care outlined work by Nel Noddings (1984; 1992). In this paper I continue that project by indicating how Noddings' work provides signposts for environmental educators to…

  13. Caring to Care: Applying Noddings' Philosophy to Medical Education. (United States)

    Balmer, Dorene F; Hirsh, David A; Monie, Daphne; Weil, Henry; Richards, Boyd F


    The authors argue that Nel Noddings' philosophy, "an ethic of caring," may illuminate how students learn to be caring physicians from their experience of being in a caring, reciprocal relationship with teaching faculty. In her philosophy, Noddings acknowledges two important contextual continuities: duration and space, which the authors speculate exist within longitudinal integrated clerkships. In this Perspective, the authors highlight core features of Noddings' philosophy and explore its applicability to medical education. They apply Noddings' philosophy to a subset of data from a previously published longitudinal case study to explore its "goodness of fit" with the experience of eight students in the 2012 cohort of the Columbia-Bassett longitudinal integrated clerkship. In line with Noddings' philosophy, the authors' supplementary analysis suggests that students (1) recognized caring when they talked about "being known" by teaching faculty who "cared for" and "trusted" them; (2) responded to caring by demonstrating enthusiasm, action, and responsibility toward patients; and (3) acknowledged that duration and space facilitated caring relations with teaching faculty. The authors discuss how Noddings' philosophy provides a useful conceptual framework to apply to medical education design and to future research on caring-oriented clinical training, such as longitudinal integrated clerkships.

  14. The German health care system and health care reform. (United States)

    Kamke, K


    This article presents a structured survey of the German health care and health insurance system, and analyzes major developments of current German health policy. The German statutory health insurance system has been known as a system that provides all citizens with ready access to comprehensive high quality medical care at a cost the country considered socially acceptable. However, an increasing concern for rapidly rising health care expenditure led to a number of cost-containment measures since 1977. The aim was to bring the growth of health care expenditure in line with the growth of wages and salaries of the sickness fund members. The recent health care reforms of 1989 and 1993 yielded only short-term reductions of health care expenditure, with increases in the subsequent years. 'Stability of the contribution rate' is the uppermost political objective of current health care reform initiatives. Options under discussion include reductions in the benefit package and increases of patients' co-payments. The article concludes with the possible consequences of the 1997 health care reform of which the major part became effective 1 July 1997.

  15. Care Transitions in Long-term Care and Acute Care: Health Information Exchange and Readmission Rates. (United States)

    Yeaman, Brian; Ko, Kelly J; Alvarez del Castillo, Rodolfo


    Care transitions between settings are a well-known cause of medical errors. A key component of transition is information exchange, especially in long-term care (LTC). However, LTC is behind other settings in adoption of health information technologies (HIT). In this article, we provide some brief background information about care transitions in LTC and concerns related to technology. We describe a pilot project using HIT and secure messaging in LTC to facilitate electronic information exchange during care transitions. Five LTC facilities were included, all located within Oklahoma and serviced by the same regional health system. The study duration was 20 months. Both inpatient readmission and return emergency department (ED) visit rates were lower than baseline following implementation. We provide discussion of positive outcomes, lessons learned, and limitations. Finally, we offer implications for practice and research for implementation of HIT and information exchange across care settings that may contribute to reduction in readmission rates in acute care and ED settings.


    Directory of Open Access Journals (Sweden)

    Jasenka Ćosić


    Full Text Available Fusarium species from section Discolor are widespread and well-known and play an important role in disease etiology of wheat, barley and maize. F. graminearum and F. culmorum were isolated during a four-year period at several locations in Eastern Croatia and from different hosts. The mycelium development of 236isolates of F. graminearum and 2 isolates of F. culmorum was cultered during an eight day period on water agar, PDA, Bilai, Czapek's and CLA agar at temperatures 5°, 15°, 20°, 25° and 30°C and a 12 hour dark/light regime. The results show that agar medium does not influence colony diameter significantly. The agar medium influences the richness and density of the aerial mycelium significantly, although the shape and compactness of the mycelium is not only the result of the medium on which the fungus is developed, but also of the characteristics of the species itself. The sporulation of F. culmorum was abundant on all investigated medium, whereas the sporulation of F. graminearum was very weak on PDA and Bilai agar and it was medium on CLA.

  17. The Effect of Nanosilver on Pigments Production by Fusarium culmorum (W. G. Sm.) Sacc

    DEFF Research Database (Denmark)

    Kasprowicz, Marek J.; Gorczyca, Anna; Frandsen, Rasmus John Normand


    A disk-diffusion method experiment assessed the impact of nanosilver on production of secondary metabolites (pigments) by the Fusarium culmorum fungus. Nanosilver colloidal particles in water have been obtained by the use of a method based on high voltage electric arcs between silver electrodes....... The silver nanoparticles size in colloid ranged between 15 and 100 nm and 7, 35 and 70 ppm concentration. Nanosilver modifies the metabolism of the researched F. culmorum strain. Coming into contact with nanosilver colloids induces more intensive mycelia pigmentation correlated with nanosilver concentration...


    Directory of Open Access Journals (Sweden)



    Full Text Available Chilli (Capsicum annum L. belongs to the family solanaceae is mainly cultivated for its vegetable green fruits and dry chilli as the spice. It is believed to be originated from South America. It is a rich source of Vitamin C, A and B. Chilli is valued for pungency which is imparted by an alkaloid, Capsaicin and the red pigments (Capsanthin, Capsorubin and Capxanthin. Chillies are widely used as spice, condiment, culinary, supplement, medicine, vegetable and are ornamental plants too. It is an important food flavouring ingredientfor flavouring many vegetarian and non-vegetarian food products. In view of its multifarious uses, the demand for chillies has been on the increase world over. In India it is an important cash crop, which is grown for the domestic market and for export. In India, chillies are grown in almost all states of the country and the major growing states in terms of production are Andhra Pradesh, Karnataka, Orissa, Maharashtra, West Bengal, Rajasthan and Tamil Nadu. There are several varieties of chilli cultivated in India. The most popular among these are, Sannam, LC334, Byadagi, Wonderhot, Jwala etc. The crop suffers from many diseases like damping off, anthracnose or fruit rot or dieback, wilt, leaf spots and powdery mildew. Among the fungal diseases, root rot of chilli caused by Sclerotium rolfsii has attained the economic importance. In recent years, this disease is causing the economic losses in chillies crop (Kalmesh and Gurjar 2001.

  19. Algunas citas recientes de especies del género Phoma Sacc. en Catalunya


    Nadal i Puigdefabregas, Martí


    Se citan 14 táxones del género Phoma (Ph. cava, Ph. epicoccinu, Ph. exigua, Ph.exigua var. foveata, Ph. glomerata, Ph. hedericola, Ph. herbarum, Ph. jolyana, Ph. leveillei, Ph. lycopersici, Ph. macrostoma, Ph. medicaginis var. pinodella, Ph. pomorum y Ph.tracheiphila). Para cada uno de los táxones se indica la fecha de recolección y la especie vegetal sobre la cual se desarrollaba. On cite 14 taxons du genre Phoma (Ph. cava, Ph. epicoccina, Ph. exigua, Ph.exigua var. foveata, Ph. glomerata...




    La quitosana y sus derivados reducen marcadamente el crecimiento micelial de algunos hongos con un mayor efecto inhibitorio a elevadas concentraciones. El efecto fungistático y fungicida in vitro de la quitosana y el hidrolizado de quitosana fue investigado sobre el hongo Pyricularia grisea. El experimento se realizó en el laboratorio de Microbiología del Departamento de Fisiología y Bioquímica Vegetal del Instituto Nacional de Ciencias Agrícolas (INCA). Se encontró que ambos principios activ...