Sample records for cardiovascular applications inherent

  1. Clinical application of cardiovascular pharmacogenetics. (United States)

    Voora, Deepak; Ginsburg, Geoffrey S


    Pharmacogenetics primarily uses genetic variation to identify subgroups of patients who may respond differently to a certain medication. Since its first description, the field of pharmacogenetics has expanded to study a broad range of cardiovascular drugs and has become a mainstream research discipline. Three principle classes of pharmacogenetic markers have emerged: 1) pharmacokinetic; 2) pharmacodynamic; and 3) underlying disease mechanism. In the realm of cardiovascular pharmacogenetics, significant advances have identified markers in each class for a variety of therapeutics, some with a potential for improving patient outcomes. While ongoing clinical trials will determine if routine use of pharmacogenetic testing may be beneficial, the data today support pharmacogenetic testing for certain variants on an individualized, case-by-case basis. Our primary goal is to review the association data for the major pharmacogenetic variants associated with commonly used cardiovascular medications: antiplatelet agents, warfarin, statins, beta-blockers, diuretics, and antiarrhythmic drugs. In addition, we highlight which variants and in which contexts pharmacogenetic testing can be implemented by practicing clinicians. The pace of genetic discovery has outstripped the generation of the evidence justifying its clinical adoption. Until the evidentiary gaps are filled, however, clinicians may choose to target therapeutics to individual patients whose genetic background indicates that they stand to benefit the most from pharmacogenetic testing.

  2. Safety assessment in plant layout design using indexing approach: implementing inherent safety perspective. Part 1 - guideword applicability and method description. (United States)

    Tugnoli, Alessandro; Khan, Faisal; Amyotte, Paul; Cozzani, Valerio


    Layout planning plays a key role in the inherent safety performance of process plants since this design feature controls the possibility of accidental chain-events and the magnitude of possible consequences. A lack of suitable methods to promote the effective implementation of inherent safety in layout design calls for the development of new techniques and methods. In the present paper, a safety assessment approach suitable for layout design in the critical early phase is proposed. The concept of inherent safety is implemented within this safety assessment; the approach is based on an integrated assessment of inherent safety guideword applicability within the constraints typically present in layout design. Application of these guidewords is evaluated along with unit hazards and control devices to quantitatively map the safety performance of different layout options. Moreover, the economic aspects related to safety and inherent safety are evaluated by the method. Specific sub-indices are developed within the integrated safety assessment system to analyze and quantify the hazard related to domino effects. The proposed approach is quick in application, auditable and shares a common framework applicable in other phases of the design lifecycle (e.g. process design). The present work is divided in two parts: Part 1 (current paper) presents the application of inherent safety guidelines in layout design and the index method for safety assessment; Part 2 (accompanying paper) describes the domino hazard sub-index and demonstrates the proposed approach with a case study, thus evidencing the introduction of inherent safety features in layout design.

  3. Clinical applications of cardiovascular magnetic resonance imaging

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    Marcu, C.B.; Beek, A.M.; Van Rossum, A.C. [Hospital of Saint Raphael, Cardiac Diagnostic Unit, New Haven, CT (United States)], E-mail:


    Cardiovascular magnetic resonance imaging (MRI) has evolved from an effective research tool into a clinically proven, safe and comprehensive imaging modality. It provides anatomic and functional information in acquired and congenital heart disease and is the most precise technique for quantification of ventricular volumes, function and mass. Owing to its excellent interstudy reproducibility, cardiovascular MRI is the optimal method for assessment of changes in ventricular parameters after therapeutic intervention. Delayed contrast enhancement is an accurate and robust method used in the diagnosis of ischemic and nonischemic cardiomyopathies and less common diseases, such as cardiac sarcoidosis and myocarditis. First-pass magnetic contrast myocardial perfusion is becoming an alternative to radionuclide techniques for the detection of coronary atherosclerotic disease. In this review we outline the techniques used in cardiovascular MRI and discuss the most common clinical applications. (author)

  4. Plasma proteomics to identify biomarkers - Application to cardiovascular diseases

    DEFF Research Database (Denmark)

    Beck, Hans Christian; Overgaard, Martin; Melholt Rasmussen, Lars


    , this technology may therefore identify new biomarkers that previously have not been associated with cardiovascular diseases. In this review, we summarize the key challenges and considerations, including strategies, recent discoveries and clinical applications in cardiovascular proteomics that may lead...

  5. Inherent Tracers for Carbon Capture and Storage in Sedimentary Formations: Composition and Applications. (United States)

    Flude, Stephanie; Johnson, Gareth; Gilfillan, Stuart M V; Haszeldine, R Stuart


    Inherent tracers-the "natural" isotopic and trace gas composition of captured CO2 streams-are potentially powerful tracers for use in CCS technology. This review outlines for the first time the expected carbon isotope and noble gas compositions of captured CO2 streams from a range of feedstocks, CO2-generating processes, and carbon capture techniques. The C-isotope composition of captured CO2 will be most strongly controlled by the feedstock, but significant isotope fractionation is possible during capture; noble gas concentrations will be controlled by the capture technique employed. Comparison with likely baseline data suggests that CO2 generated from fossil fuel feedstocks will often have δ(13)C distinguishable from storage reservoir CO2. Noble gases in amine-captured CO2 streams are likely to be low concentration, with isotopic ratios dependent on the feedstock, but CO2 captured from oxyfuel plants may be strongly enriched in Kr and Xe which are potentially valuable subsurface tracers. CO2 streams derived from fossil fuels will have noble gas isotope ratios reflecting a radiogenic component that will be difficult to distinguish in the storage reservoir, but inheritance of radiogenic components will provide an easily recognizable signature in the case of any unplanned migration into shallow aquifers or to the surface.

  6. On the inherent properties of Soluplus and its application in ibuprofen solid dispersions generated by microwave-quench cooling technology. (United States)

    Shi, Nian-Qiu; Lai, Hong-Wei; Zhang, Yong; Feng, Bo; Xiao, Xiao; Zhang, Hong-Mei; Li, Zheng-Qiang; Qi, Xian-Rong


    Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, or Soluplus(®), is a relatively new copolymer and a promising carrier of amorphous solid dispersions. Knowledge on the inherent properties of Soluplus(®) (e.g. cloud points, critical micelle concentrations, and viscosity) in different conditions is relatively inadequate, and the application characteristics of Soluplus(®)-based solid dispersions made by microwave methods still need to be clarified. In the present investigation, the inherent properties of a Soluplus(®) carrier, including cloud points, critical micelle concentrations, and viscosity, were explored in different media and in altered conditions. Ibuprofen, a BCS class II non-steroidal anti-inflammatory drug, was selected to develop Soluplus(®)-based amorphous solid dispersions using the microwave-quench cooling (MQC) method. Scanning electronic microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Raman spectroscopy (RS), and Fourier transform infrared spectroscopy (FT-IR) were adopted to analyze amorphous properties and molecular interactions in ibuprofen/Soluplus(®) amorphous solid dispersions generated by MQC. Dissolution, dissolution extension, phase solubility, equilibrium solubility, and supersaturated crystallization inhibiting experiments were performed to elucidate the effects of Soluplus(®) on ibuprofen in solid dispersions. This research provides valuable information on the inherent properties of Soluplus(®) and presents a basic understanding of Soluplus(®) as a carrier of amorphous solid dispersions.

  7. Applications of 3D printing in cardiovascular diseases. (United States)

    Giannopoulos, Andreas A; Mitsouras, Dimitris; Yoo, Shi-Joon; Liu, Peter P; Chatzizisis, Yiannis S; Rybicki, Frank J


    3D-printed models fabricated from CT, MRI, or echocardiography data provide the advantage of haptic feedback, direct manipulation, and enhanced understanding of cardiovascular anatomy and underlying pathologies. Reported applications of cardiovascular 3D printing span from diagnostic assistance and optimization of management algorithms in complex cardiovascular diseases, to planning and simulating surgical and interventional procedures. The technology has been used in practically the entire range of structural, valvular, and congenital heart diseases, and the added-value of 3D printing is established. Patient-specific implants and custom-made devices can be designed, produced, and tested, thus opening new horizons in personalized patient care and cardiovascular research. Physicians and trainees can better elucidate anatomical abnormalities with the use of 3D-printed models, and communication with patients is markedly improved. Cardiovascular 3D bioprinting and molecular 3D printing, although currently not translated into clinical practice, hold revolutionary potential. 3D printing is expected to have a broad influence in cardiovascular care, and will prove pivotal for the future generation of cardiovascular imagers and care providers. In this Review, we summarize the cardiovascular 3D printing workflow, from image acquisition to the generation of a hand-held model, and discuss the cardiovascular applications and the current status and future perspectives of cardiovascular 3D printing.

  8. High efficiency isolated DC/DC converter inherently optimized for fuel cell applications

    DEFF Research Database (Denmark)

    Petersen, Lars Press; Jensen, Lasse Crone; Larsen, Martin Norgaard


    The isolated full-bridge boost converter has been suggested as the best choice for fuel cell applications. Comparisons have been carried out in the literature using both stress factors and experimental verified designs to determine the optimal converter. Never the less, this paper suggests a diff...

  9. [Insulin: cardiovascular effects and therapeutic applications]. (United States)

    Schaan, Beatriz D; Rabelo, Eneida R; Irigoyen, Maria Cláudia


    Several studies have suggested a beneficial role of insulin and glucose infusions after myocardial infarction and in critically ill diabetic and non-diabetic patients. However, the insulin-glucose infusions are not routinely given to these patients, since no large randomized control trial was carried out, mechanisms involved in the benefits obtained are poorly understood, infusion protocols are complex and finally, health professionals need to change their cultural premises to apply them in their practice. Insulin has beneficial cardiovascular effects, such as the optimization of substrate use by cardiomyocites, coronary vasodilation, anti-inflammatory action and direct anti-apoptotic effects on myocardial cells. In this context, clinical studies of glucose and insulin infusions after myocardial infarction and cardiovascular surgery are reviewed, as well as possible pathophysiologic mechanisms leading to these benefits, and finally, a practical algorithm is proposed for use in intensive care and cardiovascular postoperative care units.

  10. Therapeutic applications of circadian rhythms for the cardiovascular system

    Directory of Open Access Journals (Sweden)

    Elena V Tsimakouridze


    Full Text Available The cardiovascular system exhibits dramatic time-of-day dependent rhythms, for example the diurnal variation of heart rate, blood pressure, and timing of onset of adverse cardiovascular events such as heart attack and sudden cardiac death. Over the past decade, the circadian clock mechanism has emerged as a crucial factor regulating these daily fluctuations. Most recently, these studies have led to a growing clinical appreciation that targeting circadian biology offers a novel therapeutic approach towards cardiovascular (and other diseases. Here we describe leading-edge therapeutic applications of circadian biology including 1 timing of therapy to maximize efficacy in treating heart disease (chronotherapy; 2 novel biomarkers discovered by testing for genomic, proteomic, metabolomic or other factors at different times of day and night (chronobiomarkers; and 3 novel pharmacologic compounds that target the circadian mechanism with potential clinical applications (new chronobiology drugs. Cardiovascular disease remains a leading cause of death worldwide and new approaches in the management and treatment of heart disease are clearly warranted and can benefit patients clinically.

  11. Dextran grafting on PTFE surface for cardiovascular applications


    Michel, Eléonore C; Montaño-Machado, Vanessa; Chevallier, Pascale; Labbé-Barrère, Amélie; Letourneur, Didier; Mantovani, Diego


    The modification of biomaterial surfaces with biomolecules influences the biological response. In this work, caboxymethyldextrans (CMD) with different degrees of substitution have been grafted to surfaces by introduction of amino moieties directly onto the substrate surface. Polytetrafluoroethylene was selected as a model substrate for biomaterial as it is already largely used for cardiovascular clinical applications. Firstly, CMD polymers were characterized by FTIR, 1H-NMR, and conductimetri...

  12. Biomaterials in Cardiovascular Research: Applications and Clinical Implications

    Directory of Open Access Journals (Sweden)

    Saravana Kumar Jaganathan


    Full Text Available Cardiovascular biomaterials (CB dominate the category of biomaterials based on the demand and investments in this field. This review article classifies the CB into three major classes, namely, metals, polymers, and biological materials and collates the information about the CB. Blood compatibility is one of the major criteria which limit the use of biomaterials for cardiovascular application. Several key players are associated with blood compatibility and they are discussed in this paper. To enhance the compatibility of the CB, several surface modification strategies were in use currently. Some recent applications of surface modification technology on the materials for cardiovascular devices were also discussed for better understanding. Finally, the current trend of the CB, endothelization of the cardiac implants and utilization of induced human pluripotent stem cells (ihPSCs, is also presented in this review. The field of CB is growing constantly and many new investigators and researchers are developing interest in this domain. This review will serve as a one stop arrangement to quickly grasp the basic research in the field of CB.

  13. cardiovasculares

    Directory of Open Access Journals (Sweden)

    Cristina Guerrero


    Full Text Available Uno de los aspectos que más discusión ha suscitado en los últimos tiempos entre quienes nos dedicamos al estudio de la emoción tiene que ver con la eventual asociación entre percepción, valoración y respuesta fisiológica. Esto es, siguiendo la máxima aristotélica, cabría cuestionar si las cosas son como son o son como cada quien las percibe. El objetivo de este experimento ha sido establecer la existencia de una conexión entre percepción de control y responsividad cardiovascular. La muestra estudiada ha estado conformada por estudiantes de la Universidad de Castellón; todos ellos han participado de forma voluntaria. La prueba de estrés ha consistido en un examen real de una asignatura troncal de la titulación que cursaban los participantes. Así pues, utilizando una situación de estrés real, hipotetizamos que las respuestas cardiovasculares (medidas a través de la tasa cardiaca, la presión sanguínea sistólica y la presión sanguínea diastólica dependen de la percepción de control que el individuo tiene, o cree tener, sobre la situación.

  14. Microarray, SAGE and their applications to cardiovascular diseases

    Institute of Scientific and Technical Information of China (English)


    The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE technologies and point out their limitations. We will then discuss the major discoveries and the new biological insightsthat have emerged from their applications to cardiovascular diseases. Finally we will touch upon potential challenges and future developments in this area.

  15. Understanding the application of stem cell therapy in cardiovascular diseases

    Directory of Open Access Journals (Sweden)

    Sharma RK


    Full Text Available Rakesh K Sharma, Donald J Voelker, Roma Sharma, Hanumanth K ReddyUniversity of Arkansas for Medical Sciences, Medical Center of South Arkansas, El Dorado, AR, USAAbstract: Throughout their lifetime, an individual may sustain many injuries and recover spontaneously over a period of time, without even realizing the injury in the first place. Wound healing occurs due to a proliferation of stem cells capable of restoring the injured tissue. The ability of adult stem cells to repair tissue is dependent upon the intrinsic ability of tissues to proliferate. The amazing capacity of embryonic stem cells to give rise to virtually any type of tissue has intensified the search for similar cell lineage in adults to treat various diseases including cardiovascular diseases. The ability to convert adult stem cells into pluripotent cells that resemble embryonic cells, and to transplant those in the desired organ for regenerative therapy is very attractive, and may offer the possibility of treating harmful disease-causing mutations. The race is on to find the best cells for treatment of cardiovascular disease. There is a need for the ideal stem cell, delivery strategies, myocardial retention, and time of administration in the ideal patient population. There are multiple modes of stem cell delivery to the heart with different cell retention rates that vary depending upon method and site of injection, such as intra coronary, intramyocardial or via coronary sinus. While there are crucial issues such as retention of stem cells, microvascular plugging, biodistribution, homing to myocardium, and various proapoptotic factors in the ischemic myocardium, the regenerative potential of stem cells offers an enormous impact on clinical applications in the management of cardiovascular diseases.Keywords: stem cell therapy, stem cell delivery, cardiovascular diseases, myocardial infarction, cardiomyopathy

  16. A circulating fluidized bed combustor system with inherent CO{sub 2} separation : application of chemical looping combustion

    Energy Technology Data Exchange (ETDEWEB)

    Johansson, E.; Lyngfelt, A.; Mattisson, T.; Johnsson, F. [Chalmers Univ. of Technology, Goteborg (Sweden). Dept. of Energy Conversion


    This paper presents a method to achieve carbon dioxide-free combustion while still using fossil fuels as the energy source. The method is based on separation and disposal of carbon dioxide from combustion. Chemical looping combustion (CLC) uses metal oxide particles to transfer oxygen from air to a gaseous fuel. The gaseous fuel is combusted with inherent separation of carbon dioxide (a greenhouse gas) from the flue gas. A bubbling bed below the downcomer in the circulating fluidized bed acts as a fuel reactor where oxygen is transferred from the metal oxide to the fuel. The riser acts as the air reactor where the oxygen from the air oxidizes the previously reduced metal oxide. The fuel and combustion air are not in direct contact. The conceptual design of the pressurized CLC system was examined in order to map suitable conditions for the riser and to achieve sufficient net solids flux between the reactors and the bed mass in the riser. A range of possible operating conditions were suggested. The operating conditions depend on the reaction properties of the oxygen carriers. 16 refs., 1 tab., 8 figs.

  17. Biodegradable Metals for Cardiovascular Stent Application: Interests and New Opportunities

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    Maryam Moravej


    Full Text Available During the last decade, biodegradable metallic stents have been developed and investigated as alternatives for the currently-used permanent cardiovascular stents. Degradable metallic materials could potentially replace corrosion-resistant metals currently used for stent application as it has been shown that the role of stenting is temporary and limited to a period of 6–12 months after implantation during which arterial remodeling and healing occur. Although corrosion is generally considered as a failure in metallurgy, the corrodibility of certain metals can be an advantage for their application as degradable implants. The candidate materials for such application should have mechanical properties ideally close to those of 316L stainless steel which is the gold standard material for stent application in order to provide mechanical support to diseased arteries. Non-toxicity of the metal itself and its degradation products is another requirement as the material is absorbed by blood and cells. Based on the mentioned requirements, iron-based and magnesium-based alloys have been the investigated candidates for biodegradable stents. This article reviews the recent developments in the design and evaluation of metallic materials for biodegradable stents. It also introduces the new metallurgical processes which could be applied for the production of metallic biodegradable stents and their effect on the properties of the produced metals.

  18. Vowel Inherent Spectral Change

    CERN Document Server

    Assmann, Peter


    It has been traditional in phonetic research to characterize monophthongs using a set of static formant frequencies, i.e., formant frequencies taken from a single time-point in the vowel or averaged over the time-course of the vowel. However, over the last twenty years a growing body of research has demonstrated that, at least for a number of dialects of North American English, vowels which are traditionally described as monophthongs often have substantial spectral change. Vowel Inherent Spectral Change has been observed in speakers’ productions, and has also been found to have a substantial effect on listeners’ perception. In terms of acoustics, the traditional categorical distinction between monophthongs and diphthongs can be replaced by a gradient description of dynamic spectral patterns. This book includes chapters addressing various aspects of vowel inherent spectral change (VISC), including theoretical and experimental studies of the perceptually relevant aspects of VISC, the relationship between ar...

  19. A review on biodegradable materials for cardiovascular stent application (United States)

    Hou, Li-Da; Li, Zhen; Pan, Yu; Sabir, MuhammadIqbal; Zheng, Yu-Feng; Li, Li


    A stent is a medical device designed to serve as a temporary or permanent internal scaffold to maintain or increase the lumen of a body conduit. The researchers and engineers diverted to investigate biodegradable materials due to the limitation of metallic materials in stent application such as stent restenosis which requires prolonged anti platelet therapy, often result in smaller lumen after implantation and obstruct re-stenting treatments. Biomedical implants with temporary function for the vascular intervention are extensively studied in recent years. The rationale for biodegradable stent is to provide the support for the vessel in predicted period of time and then degrading into biocompatible constituent. The degradation of stent makes the re-stenting possible after several months and also ameliorates the vessel wall quality. The present article focuses on the biodegradable materials for the cardiovascular stent. The objective of this review is to describe the possible biodegradable materials for stent and their properties such as design criteria, degradation behavior, drawbacks and advantages with their recent clinical and preclinical trials.

  20. Reinforced Pericardium as a Hybrid Material for Cardiovascular Applications


    Bracaglia, Laura G.; Yu, Li; Hibino, Narutoshi; Fisher, John P.


    Pericardium-based cardiovascular devices are currently bound by a 10-year maximum lifetime due to detrimental calcification and degradation. The goal of this work is to develop a novel synthetic material to create a lasting replacement for malfunctioning or diseased tissue in the cardiovascular system. This study couples poly(propylene fumarate) (PPF) and a natural biomaterial together in an unprecedented hybrid composite and evaluates the composite versus the standard glutaraldehyde-treated ...

  1. Clinical application of neuromuscular electrical stimulation induced cardiovascular exercise. (United States)

    Caulfield, Brian; Crowe, Louis; Coughlan, Garrett; Minogue, Conor


    We need to find novel ways of increasing exercise participation, particularly in those populations who find it difficult to participate in voluntary exercise. In recent years researchers have started to investigate the potential for using electrical stimulation to artificially stimulate a pattern of muscle activity that would induce a physiological response consistent with cardiovascular exercise. Work to date has indicated that this is best achieved by using a stimulation protocol that results in rapid rhythmical isometric contractions of the large leg muscle groups at sub tetanic frequencies. Studies completed by our group indicate that this technique can serve as a viable alternative to voluntary cardiovascular exercise. Apart from being able to induce a cardiovascular exercise effect in patient populations (e.g. heart failure, COPD, spinal cord injury, obesity), this approach may also have value in promotion of exercise activity in a microgravity environment.

  2. Enantiopure inherently chiral calix[4]arene derivatives containing quinolin-2-yl-methanol moiety:Synthesis and application in the catalytic asymmetric addition of diethylzinc to benzaldehyde

    Institute of Scientific and Technical Information of China (English)


    A series of novel N,O-type chiral ligands derived from enantiopure inherently chiral calix[4]arenes containing quinolin-2-yl-methanol moiety in the cone or partialcone conformation have been synthe-sized and characterized. Moreover,they have been applied to the catalytic asymmetric addition of diethylzinc to benzaldehyde,which represents the first example that the inherently chiral calixarene can be used as the chiral ligands for the catalytic asymmetric synthesis.

  3. Expanding Application of the Wiggers Diagram to Teach Cardiovascular Physiology (United States)

    Mitchell, Jamie R.; Wang, Jiun-Jr


    Dr. Carl Wiggers' careful observations have provided a meaningful resource for students to learn how the heart works. Throughout the many years from his initial reports, the Wiggers diagram has been used, in various degrees of complexity, as a fundamental tool for cardiovascular instruction. Often, the various electrical and mechanical plots…

  4. Expanding application of the Wiggers diagram to teach cardiovascular physiology. (United States)

    Mitchell, Jamie R; Wang, Jiun-Jr


    Dr. Carl Wiggers' careful observations have provided a meaningful resource for students to learn how the heart works. Throughout the many years from his initial reports, the Wiggers diagram has been used, in various degrees of complexity, as a fundamental tool for cardiovascular instruction. Often, the various electrical and mechanical plots are the novice learner's first exposure to simulated data. As the various temporal relationships throughout a heartbeat could simply be memorized, the challenge for the cardiovascular instructor is to engage the learner so the underlying mechanisms governing the changing electrical and mechanical events are truly understood. Based on experience, we suggest some additions to the Wiggers diagram that are not commonly used to enhance cardiovascular pedagogy. For example, these additions could be, but are not limited to, introducing the concept of energy waves and their role in influencing pressure and flow in health and disease. Also, integrating concepts of exercise physiology, and the differences in cardiac function and hemodynamics between an elite athlete and normal subject, can have a profound impact on student engagement. In describing the relationship between electrical and mechanical events, the instructor may find the introduction of premature ventricular contractions as a useful tool to further understanding of this important principle. It is our hope that these examples can aid cardiovascular instructors to engage their learners and promote fundamental understanding at the expense of simple memorization.

  5. Cardiovascular Deconditioning (United States)

    Charles, John B.; Fritsch-Yelle, Janice M.; Whitson, Peggy A.; Wood, Margie L.; Brown, Troy E.; Fortner, G. William


    Spaceflight causes adaptive changes in cardiovascular function that may deleteriously affect crew health and safety. Over the last three decades, symptoms of cardiovascular changes have ranged from postflight orthostatic tachycardia and decreased exercise capacity to serious cardiac rhythm disturbances during extravehicular activities (EVA). The most documented symptom of cardiovascular dysfunction, postflight orthostatic intolerance, has affected a significant percentage of U.S. Space Shuttle astronauts. Problems of cardiovascular dysfunction associated with spaceflight are a concern to NASA. This has been particularly true during Shuttle flights where the primary concern is the crew's physical health, including the pilot's ability to land the Orbiter, and the crew's ability to quickly egress and move to safety should a dangerous condition arise. The study of astronauts during Shuttle activities is inherently more difficult than most human research. Consequently, sample sizes have been small and results have lacked consistency. Before the Extended Duration Orbiter Medical Project (EDOMP), there was a lack of normative data on changes in cardiovascular parameters during and after spaceflight. The EDOMP for the first time allowed studies on a large enough number of subjects to overcome some of these problems. There were three primary goals of the Cardiovascular EDOMP studies. The first was to establish, through descriptive studies, a normative data base of cardiovascular changes attributable to spaceflight. The second goal was to determine mechanisms of cardiovascular changes resulting from spaceflight (particularly orthostatic hypotension and cardiac rhythm disturbances). The third was to evaluate possible countermeasures. The Cardiovascular EDOMP studies involved parallel descriptive, mechanistic, and countermeasure evaluations.

  6. Novel glass-like coatings for cardiovascular implant application: Preparation, characterization and cellular interaction. (United States)

    Kiefer, Karin; Amlung, Martin; Aktas, Oral Cenk; de Oliveira, Peter W; Abdul-Khaliq, Hashim


    Glass coatings are of great interest for biomedical implant application due to their excellent properties. Nowadays they are used in different fields including drug delivery, for bone tissue regeneration or as implant. Nevertheless they can only be applied using high temperatures. Therefore their usage in the field of cardiovascular implant application is still restricted. Accordingly new developments in this field have been carried out to overcome this problem and to coat cardiovascular implants. Here, novel glass-like coatings have been developed and applied using sol-gel technique at moderate temperatures. The biocompatibility and selectivity have been analyzed using human endothelial cells. The obtained results clarify that the developed compositions can either promote or suppress endothelial cell growth only by altering the sintering atmosphere. A later application as thin layer on cardiovascular implants like stents is conceivable.

  7. Cutting edge clinical applications in cardiovascular magnetic resonance (United States)

    De Cecco, Carlo N; Muscogiuri, Giuseppe; Varga-Szemes, Akos; Schoepf, U Joseph


    Today, the use of cardiovascular magnetic resonance (CMR) is widespread in clinical practice. The increased need to evaluate of subtle myocardial changes, coronary artery anatomy, and hemodynamic assessment has prompted the development of novel CMR techniques including T1 and T2 mapping, non-contrast angiography and four dimensional (4D) flow. T1 mapping is suitable for diagnosing pathologies affecting extracellular volume such as myocarditis, diffuse myocardial fibrosis and amyloidosis, and is a promising diagnostic tool for patients with iron overload and Fabry disease. T2 mapping is useful in depicting acute myocardial edema and estimating the amount of salvageable myocardium following an ischemic event. Novel angiography techniques, such as the self-navigated whole-heart or the quiescent-interval single-shot sequence, enable the visualization of the great vessels and coronary artery anatomy without the use of contrast material. The 4D flow technique overcomes the limitations of standard phase-contrast imaging and allows for the assessment of cardiovascular hemodynamics in the great arteries and flow patterns in the cardiac chambers. In conclusion, the future of CMR is heading toward a more reliable quantitative assessment of the myocardium, an improved non-contrast visualization of the coronary artery anatomy, and a more accurate evaluation of the cardiac hemodynamics. PMID:28144400

  8. Cardiovascular physiology at the bench for application in the clinic. (United States)

    Zhang, Cuihua


    Our research focuses on microphysiological aspects of the cardiovascular system, with an emphasis on what is occurring in heart tissues, to learn more about how various diseases arise and how they can be avoided or cured. These diseases include atherosclerosis, diabetes, myocardial infarction, obesity and ischemia/reperfusion (I/R). We use animal models, particularly mice, to aid us in these studies. A key feature of our work centers on dissection of coronary arterioles and examining their functionality using drugs, electrophysiology, fluoroscopy, genomics, proteomics, and standard chemical analyses to determine their physiological status, and compare it with other treated animals. My laboratory is focusing on anti-inflammatory and antioxidative stress therapeutic effects, the roles of sodium salicylate, exercise and resveratrol in type 2 diabetes, I/R injury, obesity, and atherosclerosis. Recently, we began investigations of the effects of stem cells and gastric bypass surgery on vascular dysfunction in obesity and diabetes. Our work identifies how diet, exercise, surgical interventions and drugs can be considered to combat these diseases in a clinical setting.

  9. Application of Hybrid Dynamical Theory to the Cardiovascular System

    KAUST Repository

    Laleg-Kirati, Taous-Meriem


    In hybrid dynamical systems, the state evolves in continuous time as well as in discrete modes activated by internal conditions or by external events. In the recent years, hybrid systems modeling has been used to represent the dynamics of biological systems. In such systems, discrete behaviors might originate from unexpected changes in normal performance, e.g., a transition from a healthy to an abnormal condition. Simplifications, model assumptions, and/or modeled (and ignored) nonlinearities can be represented by sudden changes in the state. Modeling cardiovascular system (CVS), one of the most fascinating but most complex human physiological systems, with a hybrid approach, is the focus of this chapter. The hybrid property appears naturally in the CVS thanks to the presence of valves which, depending on their state (closed or open), divide the cardiac cycle into four phases. This chapter shows how hybrid models can be used for modeling the CVS. In addition, it describes a preliminary study on the detection of some cardiac anomalies based on the hybrid model and using the standard observer-based approach.

  10. Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease

    DEFF Research Database (Denmark)

    Amir, Shahzada; Hartvigsen, Karsten; Gonen, Ayelet;


    . Furthermore, MDA mimotopes were found to mimic MDA epitopes on the surface of apoptotic cells. Immunization of mice with P2 resulted in the induction of MDA-LDL-specific Abs, which strongly immunostained human atherosclerotic lesions. We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy....... These mimotopes can serve as standardized and reproducible antigens that will be useful for diagnostic and therapeutic applications in cardiovascular disease....

  11. Inherent emotional quality of human speech sounds. (United States)

    Myers-Schulz, Blake; Pujara, Maia; Wolf, Richard C; Koenigs, Michael


    During much of the past century, it was widely believed that phonemes-the human speech sounds that constitute words-have no inherent semantic meaning, and that the relationship between a combination of phonemes (a word) and its referent is simply arbitrary. Although recent work has challenged this picture by revealing psychological associations between certain phonemes and particular semantic contents, the precise mechanisms underlying these associations have not been fully elucidated. Here we provide novel evidence that certain phonemes have an inherent, non-arbitrary emotional quality. Moreover, we show that the perceived emotional valence of certain phoneme combinations depends on a specific acoustic feature-namely, the dynamic shift within the phonemes' first two frequency components. These data suggest a phoneme-relevant acoustic property influencing the communication of emotion in humans, and provide further evidence against previously held assumptions regarding the structure of human language. This finding has potential applications for a variety of social, educational, clinical, and marketing contexts.

  12. The potential application and challenge of powerful CRISPR/Cas9 system in cardiovascular research. (United States)

    Li, Yangxin; Song, Yao-Hua; Liu, Bin; Yu, Xi-Yong


    CRISPR/Cas9 is a precision-guided munition found in bacteria to fight against invading viruses. This technology has enormous potential applications, including altering genes in both somatic and germ cells, as well as generating knockout animals. Compared to other gene editing techniques such as zinc finger nucleases and TALENS, CRISPR/Cas9 is much easier to use and highly efficient. Importantly, the multiplex capacity of this technology allows multiple genes to be edited simultaneously. CRISPR/Cas9 also has the potential to prevent and cure human diseases. In this review, we wish to highlight some key points regarding the future prospect of using CRISPR/Cas9 as a powerful tool for cardiovascular research, and as a novel therapeutic strategy to treat cardiovascular diseases.

  13. Statistical Validation of a Web-Based GIS Application and Its Applicability to Cardiovascular-Related Studies

    Directory of Open Access Journals (Sweden)

    Jae Eun Lee


    Full Text Available Purpose: There is abundant evidence that neighborhood characteristics are significantly linked to the health of the inhabitants of a given space within a given time frame. This study is to statistically validate a web-based GIS application designed to support cardiovascular-related research developed by the NIH funded Research Centers in Minority Institutions (RCMI Translational Research Network (RTRN Data Coordinating Center (DCC and discuss its applicability to cardiovascular studies. Methods: Geo-referencing, geocoding and geospatial analyses were conducted for 500 randomly selected home addresses in a U.S. southeastern Metropolitan area. The correlation coefficient, factor analysis and Cronbach’s alpha (α were estimated to quantify measures of the internal consistency, reliability and construct/criterion/discriminant validity of the cardiovascular-related geospatial variables (walk score, number of hospitals, fast food restaurants, parks and sidewalks. Results: Cronbach’s α for CVD GEOSPATIAL variables was 95.5%, implying successful internal consistency. Walk scores were significantly correlated with number of hospitals (r = 0.715; p < 0.0001, fast food restaurants (r = 0.729; p < 0.0001, parks (r = 0.773; p < 0.0001 and sidewalks (r = 0.648; p < 0.0001 within a mile from homes. It was also significantly associated with diversity index (r = 0.138, p = 0.0023, median household incomes (r = −0.181; p < 0.0001, and owner occupied rates (r = −0.440; p < 0.0001. However, its non-significant correlation was found with median age, vulnerability, unemployment rate, labor force, and population growth rate. Conclusion: Our data demonstrates that geospatial data generated by the web-based application were internally consistent and demonstrated satisfactory validity. Therefore, the GIS application may be useful to apply to cardiovascular-related studies aimed to investigate potential impact of geospatial factors on diseases and/or the long

  14. Inherently Unstable Internal Gravity Waves

    CERN Document Server

    Liang, Y


    Here we show that there exist internal gravity waves that are inherently unstable, that is, they cannot exist in nature for a long time. The instability mechanism is a one-way (irreversible) harmonic-generation resonance that permanently transfers the energy of an internal wave to its higher harmonics. We show that, in fact, there are countably infinite number of such unstable waves. For the harmonic-generation resonance to take place, nonlinear terms in the free surface boundary condition play a pivotal role, and the instability does not obtain if a simplified boundary condition such as rigid lid or linear form is employed. Harmonic-generation resonance presented here also provides a mechanism for the transfer of the energy of the internal waves to the higher-frequency part of the spectrum where internal waves are more prone to breaking, hence losing energy to turbulence and heat and contributing to oceanic mixing.

  15. Translational applications of molecular imaging in cardiovascular disease and stem cell therapy. (United States)

    Du, Wei; Tao, Hongyan; Zhao, Shihua; He, Zuo-Xiang; Li, Zongjin


    Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. Molecular imaging techniques provide valuable information at cellular and molecular level, as opposed to anatomical and structural layers acquired from traditional imaging modalities. More specifically, molecular imaging employs imaging probes which interact with specific molecular targets and therefore makes it possible to visualize biological processes in vivo. Molecular imaging technology is now progressing towards preclinical and clinical application that gives an integral and comprehensive guidance for the investigation of cardiovascular disease. In addition, cardiac stem cell therapy holds great promise for clinical translation. Undoubtedly, combining stem cell therapy with molecular imaging technology will bring a broad prospect for the study and treatment of cardiac disease. This review will focus on the progresses of molecular imaging strategies in cardiovascular disease and cardiac stem cell therapy. Furthermore, the perspective on the future role of molecular imaging in clinical translation and potential strategies in defining safety and efficacy of cardiac stem cell therapies will be discussed.

  16. Elastin-like Polypeptide Enriched Surfaces for Cardiovascular Applications through the use of Bioactive Fluorinated Surface Modifiers (United States)

    Blit, Patrick Herve

    Currently used small diameter synthetic vascular grafts are prone to high rates of failure related to thrombosis and neointimal hyperplasia. Biomimetic materials, based on the extracellular matrix (ECM) composition of native tissues, represent an attractive solution to address these complications. The inherent low thrombogenicity and cell signalling properties of elastin-like polypeptides (ELPs) make them a suitable option for these applications. In this thesis, ELP surface modification has been achieved through the use of elastin cross-linking peptide bioactive fluorinated surface modifiers (ECP-BFSMs). The synthesis of these low molecular weight fluorinated additives was described and their subsequent blending with a base polycarbonate-urethane (PCNU) was shown to successfully enrich the surface to allow for ELP surface cross-linking. The kinetic surface migration of fluorescent ECP-BFSMs was studied over a 2 week casting period by two-photon confocal microscopy. Contact angle and x-ray photoelectron spectroscopy (XPS) confirmed the surface localization of the ECP-BFSMs. Changes in contact angle and XPS spectrums following ELP surface cross-linking confirmed the success of the surface modification approach. The novel ELP surface modified materials were demonstrated to inhibit fibrinogen surface adsorption and platelet adhesion under physiological flow conditions and inhibit bulk platelet activation following blood-material contact. Moreover, these ELP modified surfaces were shown to promote increased endothelial and smooth muscle cell adhesion, spreading and retention over a 7 day culture period relative to their non-ELP analogs. Endothelial and smooth muscle cells seeded on the elastin-like materials were shown to express endothelial nitric oxide synthase (eNOS) and smooth muscle myosin heavy chain (SM-MHC) cell specific phenotypic markers, respectively. Furthermore, competitive inhibition experiments revealed that initial smooth muscle cell adhesion to ELP

  17. Immediate effect of ice bag application to head and spine on cardiovascular changes in healthy volunteers

    Directory of Open Access Journals (Sweden)

    A Mooventhan


    Full Text Available Background/Objectives: Ice application is one of the treatment procedures used in hydrotherapy. Though its various physiological/therapeutic effects were reported, ice bag application (IBA to head and spine on cardiovascular changes were not reported. Hence, this study aims at evaluating the immediate effect of IBA to head and spine on cardiovascular changes in healthy volunteers. Materials and Methods: Twenty-eight subjects were randomized into three sessions ([i] IBA [ii] tap water bag application [TWBA] and [iii] control and intervention was given in one of the 3-different orders. Systolic blood pressure (SBP, diastolic blood pressure (DBP, and pulse rate (PR was assessed before and after 20-min of each intervention. Pulse pressure, mean pressure (MP, rate pressure product (RPP, and double product (Do-P were derived by standard formula. Statistical analysis was performed by repeated measures of analysis of variance and post-hoc analysis with Bonferroni adjustment for multiple comparisons with the use of Statistical Package for Social Sciences version-16. Results: The results showed no significant difference between sessions in all variables. Within-group analysis showed significant reductions in SBP, PR, RPP, Do-P in IBA and TWBA sessions; Significant reduction in DBP, MP in IBA unlike TWBA; and no significant changes in all the variables of control session. Conclusions: Result of our study suggest that though both IBA and TWBA to head and spine might be considered as having effect on improving cardiovascular function in healthy volunteers, IBA to head and spine could be considered as a better choice than TWBA.

  18. Inherently Unstable Internal Gravity Waves (United States)

    Alam, Reza


    Here we show that there exist internal gravity waves that are inherently unstable, that is, they cannot exist in nature for a long time. The instability mechanism is a one-way (irreversible) harmonic-generation resonance that permanently transfers the energy of an internal wave to its higher harmonics. We show that, in fact, there are countably infinite number of such unstable waves. For the harmonic-generation resonance to take place, nonlinear terms in the free surface boundary condition play a pivotal role, and the instability does not obtain for a linearly-stratified fluid if a simplified boundary condition such as rigid lid or linear form is employed. Harmonic-generation resonance discussed here also provides a mechanism for the transfer of the energy of the internal waves to the higher-frequency part of the spectrum where internal waves are more prone to breaking, hence losing energy to turbulence and heat and contributing to oceanic mixing. Yong Liang (

  19. Application of pre-participation cardiovascular screening guidelines to novice older runners and endurance athletes

    Directory of Open Access Journals (Sweden)

    Justin R Abbatemarco


    Full Text Available Objectives: Despite robust growth in participation in marathons and endurance sports among older individuals, guidance regarding pre-participation cardiovascular evaluation of these athletes is lacking. The objective of this study was to assess the utility of currently available pre-participation cardiovascular evaluation guidelines as applied to a cohort of older novice endurance athletes. Methods: We applied data from 1457 novice runners and endurance athletes aged 35 years and older to two pre-participation screening tools, the American Heart Association/American College of Sports Medicine Pre-Participation Questionnaire and the 2001 Working Group recommendations for pre-participation screening of masters athletes (2001 Masters. Results: Application of the American Heart Association/American College of Sports Medicine Pre-Participation Questionnaire identified 42.1% for which pre-participation cardiovascular evaluation was indicated. Of those who met criteria, 51.5% reported completion of a healthcare evaluation. Application of the 2001 Masters guidelines identified 75.2% who qualified for pre-participation electrocardiogram and 34.0% for pre-participation stress testing. Of those who met 2001 Masters criteria for pre-participation testing, 43.7% and 24.6% underwent recommended electrocardiogram and stress testing, respectively. While there was modest concordance with recommendations for pre-participation evaluations based on both American Heart Association/American College of Sports Medicine Pre-Participation Questionnaire and 2001 Masters, only athlete age was independently associated with completion of a pre-participation healthcare evaluation and only athlete age and athlete’s participation in marathons were independently associated with pre-participation stress testing. Conclusion: Among older novice endurance athletes, application of the American Heart Association/American College of Sports Medicine Pre-Participation Questionnaire

  20. Application of pre-participation cardiovascular screening guidelines to novice older runners and endurance athletes (United States)

    Abbatemarco, Justin R; Bennett, Courtney; Bell, Adrian J; Dunne, Laura; Matsumura, Martin E


    Objectives: Despite robust growth in participation in marathons and endurance sports among older individuals, guidance regarding pre-participation cardiovascular evaluation of these athletes is lacking. The objective of this study was to assess the utility of currently available pre-participation cardiovascular evaluation guidelines as applied to a cohort of older novice endurance athletes. Methods: We applied data from 1457 novice runners and endurance athletes aged 35 years and older to two pre-participation screening tools, the American Heart Association/American College of Sports Medicine Pre-Participation Questionnaire and the 2001 Working Group recommendations for pre-participation screening of masters athletes (2001 Masters). Results: Application of the American Heart Association/American College of Sports Medicine Pre-Participation Questionnaire identified 42.1% for which pre-participation cardiovascular evaluation was indicated. Of those who met criteria, 51.5% reported completion of a healthcare evaluation. Application of the 2001 Masters guidelines identified 75.2% who qualified for pre-participation electrocardiogram and 34.0% for pre-participation stress testing. Of those who met 2001 Masters criteria for pre-participation testing, 43.7% and 24.6% underwent recommended electrocardiogram and stress testing, respectively. While there was modest concordance with recommendations for pre-participation evaluations based on both American Heart Association/American College of Sports Medicine Pre-Participation Questionnaire and 2001 Masters, only athlete age was independently associated with completion of a pre-participation healthcare evaluation and only athlete age and athlete’s participation in marathons were independently associated with pre-participation stress testing. Conclusion: Among older novice endurance athletes, application of the American Heart Association/American College of Sports Medicine Pre-Participation Questionnaire and 2001 Masters

  1. Application of the Kalman Filter for Faster Strong Coupling of Cardiovascular Simulations. (United States)

    Hasegawa, Yuki; Shimayoshi, Takao; Amano, Akira; Matsuda, Tetsuya


    In this paper, we propose a method for reducing the computational cost of strong coupling for multiscale cardiovascular simulation models. In such a model, individual model modules of myocardial cell, left ventricular structural dynamics, and circulatory hemodynamics are coupled. The strong coupling method enables stable and accurate calculation, but requires iterative calculations which are computationally expensive. The iterative calculations can be reduced, if accurate initial approximations are made available by predictors. The proposed method uses the Kalman filter to estimate accurate predictions by filtering out noise included in past values. The performance of the proposed method was assessed with an application to a previously published multiscale cardiovascular model. The proposed method reduced the number of iterations by 90% and 62% compared with no prediction and Lagrange extrapolation, respectively. Even when the parameters were varied and number of elements of the left ventricular finite-element model increased, the number of iterations required by the proposed method was significantly lower than that without prediction. These results indicate the robustness, scalability, and validity of the proposed method.

  2. Multi-target drug design approaches for multifactorial diseases: from neurodegenerative to cardiovascular applications. (United States)

    Katselou, M G; Matralis, A N; Kourounakis, A P


    In multi-target drug design (MTD) medicinal chemistry aims to integrate multiple pharmacophores into a single drug molecule in order to make it active on several molecular biological mechanisms simultaneously. Given the fact that most diseases are multifactorial in nature, MTD is being pursued with increasing intensity, which has resulted in improved outcomes in disease models and several compounds have entered clinical trials. In a wide range of examples we illustrate how various functionalities have been combined within single structures and how this has affected their (pre)clinical outcome. This review describes the successful application of MTD for disorders such as neurodegenerative, cardiovascular, diabetes, metabolic and inflammatory diseases, especially focusing on the field of atherosclerosis where multi-target strategies are a promising alternative to the classical "one target-one drug" design approach.

  3. Mathematical modeling and validation in physiology applications to the cardiovascular and respiratory systems

    CERN Document Server

    Bachar, Mostafa; Kappel, Franz


    This volume synthesizes theoretical and practical aspects of both the mathematical and life science viewpoints needed for modeling of the cardiovascular-respiratory system specifically and physiological systems generally.  Theoretical points include model design, model complexity and validation in the light of available data, as well as control theory approaches to feedback delay and Kalman filter applications to parameter identification. State of the art approaches using parameter sensitivity are discussed for enhancing model identifiability through joint analysis of model structure and data. Practical examples illustrate model development at various levels of complexity based on given physiological information. The sensitivity-based approaches for examining model identifiability are illustrated by means of specific modeling  examples. The themes presented address the current problem of patient-specific model adaptation in the clinical setting, where data is typically limited.

  4. Generation and Assessment of Functional Biomaterial Scaffolds for Applications in Cardiovascular Tissue Engineering and Regenerative Medicine (United States)

    Hinderer, Svenja; Brauchle, Eva


    Current clinically applicable tissue and organ replacement therapies are limited in the field of cardiovascular regenerative medicine. The available options do not regenerate damaged tissues and organs, and, in the majority of the cases, show insufficient restoration of tissue function. To date, anticoagulant drug‐free heart valve replacements or growing valves for pediatric patients, hemocompatible and thrombus‐free vascular substitutes that are smaller than 6 mm, and stem cell‐recruiting delivery systems that induce myocardial regeneration are still only visions of researchers and medical professionals worldwide and far from being the standard of clinical treatment. The design of functional off‐the‐shelf biomaterials as well as automatable and up‐scalable biomaterial processing methods are the focus of current research endeavors and of great interest for fields of tissue engineering and regenerative medicine. Here, various approaches that aim to overcome the current limitations are reviewed, focusing on biomaterials design and generation methods for myocardium, heart valves, and blood vessels. Furthermore, novel contact‐ and marker‐free biomaterial and extracellular matrix assessment methods are highlighted. PMID:25778713

  5. The Application of Modern Training Complexes for Persons with Risk Factors for Cardio-Vascular Disorders

    Directory of Open Access Journals (Sweden)

    Anatoly T. Bykov


    Full Text Available The study featured 236 males and 33 females with risk factors for cardio-vascular disorders, who underwent a 3-week-long sanatorium-resort treatment. The patients were divided into two groups: the primary group (n = 194 and the comparison group (n = 75. The comparison group patients received traditional treatment (diet, physiotherapy, climate-, phyto-, and balneotherapy. The primary group patients were prescribed an optimized therapeutic complex that included, in addition to traditional therapy, the application of the “Kardiomed” training system. All the patients, on admission to and before discharge from the sanatorium, had the anthropometric and hemodynamic parameters controlled and the indicators of lipid and carbohydrate metabolism examined. As a result of the therapy, the primary group patients demonstrated a considerable improvement in all the indicators: a 6% decrease in abdominal adiposity, a 7.5% decrease in average daily systolic arterial blood pressure, a 24.2% decrease in the atherogenic index, and a 16.4% decrease in glycated hemoglobin. In the comparison group patients, the above indicators improved to a lesser degree.

  6. The inherent politics of quality in public park management

    DEFF Research Database (Denmark)

    Lindholst, Andrej Christian; Konijnendijk, Cecil Cornelius; Fors, Hanna


    In this paper, we highlight and illustrate the inherent politics embedded in “quality” as a concept for managing public parks. Reflecting more generic quality concepts, contemporary quality models in park management include concepts for both operational, strategic and stakeholder management as well...... managing the park organisation itself. However, quality concepts and their application through various management models include as well as exclude the access, values and worldviews of particular interests. In this way, any particular quality concept and model embeds its own politics by inherent...... allocations of ‘who gets what, when and how’. We illustrate the inherent politics by providing a case study of a widely adopted quality model for operational management that has been adopted and implemented in Denmark as part of new public management reforms. In perspective, other quality concepts and models...

  7. AFM study of the thrombogenicity of carbon-based coatings for cardiovascular applications

    Energy Technology Data Exchange (ETDEWEB)

    Karagkiozaki, V. [Department of Physics, Laboratory for Thin Films-Nanosystems and Nanometrology (LTFN), Aristotle University of Thessaloniki, Thessaloniki GR-54124 (Greece); AHEPA Hospital, 1st Cardiology Department, Aristotle University of Thessaloniki, Thessaloniki GR-54124 (Greece); Logothetidis, S. [Department of Physics, Laboratory for Thin Films-Nanosystems and Nanometrology (LTFN), Aristotle University of Thessaloniki, Thessaloniki GR-54124 (Greece)], E-mail:; Laskarakis, A. [Department of Physics, Laboratory for Thin Films-Nanosystems and Nanometrology (LTFN), Aristotle University of Thessaloniki, Thessaloniki GR-54124 (Greece); Giannoglou, G. [AHEPA Hospital, 1st Cardiology Department, Aristotle University of Thessaloniki, Thessaloniki GR-54124 (Greece); Lousinian, S. [Department of Physics, Laboratory for Thin Films-Nanosystems and Nanometrology (LTFN), Aristotle University of Thessaloniki, Thessaloniki GR-54124 (Greece)


    The new nanotechnologies in biomaterials for cardiovascular applications target at surface alterations for prevention of platelets aggregation and subsequent clotting as their usual failure arises from thrombogenicity. Knowledge of structural properties of platelets during their adhesion on nanostructure materials is required to obtain a comprehensive understanding of their activation and the conventional imaging tools require special preparation of the samples and does not guarantee the viability of the cells. Thus, in this study, the atomic force microscope (AFM) which is a non-destructive and nanoscale precision technique is implemented for the study of platelets' adhesion onto amorphous hydrogenated carbon (a-C:H) thin films and a methodology is developed. Carbon-based thin films grown by magnetron sputtering under different deposition conditions are considered to meet the requirements for biomedical applications and were selected as well-characterized, case study materials. Platelet rich plasma drawn from healthy donors was used for the study of platelets adhesion onto the a-C:H films. The fourier transform IR phase modulated spectroscopic ellipsometry (FTIRSE) (900-3500 cm{sup -1}) being a powerful, non-destructive, optical technique was used for the investigation of bonding structure of the adherent platelets onto the a-C:H materials and the contribution of the different vibration bands of the platelet bonding groups was shown and discussed. The effect of nanostructure, surface properties and wettability of the carbon thin films on their thrombogenic potential was verified and it was found that the different deposition conditions determine their structural, surface and biological properties. Thus, the tailoring of surface properties of biomaterials and the informative study of platelets-nanomaterials interactions with AFM and FTIRSE will revolutionize the development of less thrombogenic biomaterials.

  8. Stainless steel surface functionalization for immobilization of antibody fragments for cardiovascular applications. (United States)

    Foerster, A; Hołowacz, I; Sunil Kumar, G B; Anandakumar, S; Wall, J G; Wawrzyńska, M; Paprocka, M; Kantor, A; Kraskiewicz, H; Olsztyńska-Janus, S; Hinder, S J; Bialy, D; Podbielska, H; Kopaczyńska, M


    Stainless steel 316 L material is commonly used for the production of coronary and peripheral vessel stents. Effective biofunctionalization is a key to improving the performance and safety of the stents after implantation. This paper reports the method for the immobilization of recombinant antibody fragments (scFv) on stainless steel 316 L to facilitate human endothelial progenitor cell (EPC) growth and thus improve cell viability of the implanted stents for cardiovascular applications. The modification of stent surface was conducted in three steps. First the stent surface was coated with titania based coating to increase the density of hydroxyl groups for successful silanization. Then silanization with 3 aminopropyltriethoxysilane (APTS) was performed to provide the surface with amine groups which presence was verified using FTIR, XPS, and fluorescence microscopy. The maximum density of amine groups (4.8*10(-5) mol/cm(2)) on the surface was reached after reaction taking place in ethanol for 1 h at 60 °C and 0.04M APTS. On such prepared surface the glycosylated scFv were subsequently successfully immobilized. The influence of oxidation of scFv glycan moieties and the temperature on scFv coating were investigated. The fluorescence and confocal microscopy study indicated that the densest and most uniformly coated surface with scFv was obtained at 37 °C after oxidation of glycan chain. The results demonstrate that the scFv cannot be efficiently immobilized without prior aminosilanization of the surface. The effect of the chemical modification on the cell viability of EPC line 55.1 (HucPEC-55.1) was performed indicating that the modifications to the 316 L stainless steel are non-toxic to EPCs.

  9. An Energy efficient application specific integrated circuit for electrocardiogram feature detection and its potential for ambulatory cardiovascular disease detection. (United States)

    Jain, Sanjeev Kumar; Bhaumik, Basabi


    A novel algorithm based on forward search is developed for real-time electrocardiogram (ECG) signal processing and implemented in application specific integrated circuit (ASIC) for QRS complex related cardiovascular disease diagnosis. The authors have evaluated their algorithm using MIT-BIH database and achieve sensitivity of 99.86% and specificity of 99.93% for QRS complex peak detection. In this Letter, Physionet PTB diagnostic ECG database is used for QRS complex related disease detection. An ASIC for cardiovascular disease detection is fabricated using 130-nm CMOS high-speed process technology. The area of the ASIC is 0.5 mm(2). The power dissipation is 1.73 μW at the operating frequency of 1 kHz with a supply voltage of 0.6 V. The output from the ASIC is fed to their Android application that generates diagnostic report and can be sent to a cardiologist through email. Their ASIC result shows average failed detection rate of 0.16% for six leads data of 290 patients in PTB diagnostic ECG database. They also have implemented a low-leakage version of their ASIC. The ASIC dissipates only 45 pJ with a supply voltage of 0.9 V. Their proposed ASIC is most suitable for energy efficient telemetry cardiovascular disease detection system.

  10. Application of feminist theory in nursing research: the case of women and cardiovascular disease. (United States)

    McCormick, Kim M; Bunting, Sheila M


    Researchers have provided evidence that women recover from and live with heart disease in very distinct ways from men. The challenge for researchers has been to discuss women in a manner that allows their differences to emerge but does not depict them as inferior to men. Our goal is to review current cardiovascular research on women from a feminist theoretical perspective. We believe that a feminist perspective in cardiovascular research will advance the knowledge and recognition of women's health. We examined nine qualitative research articles in depth and applied a model of feminist research critique to them (Bunting, 1997). Historical androcentric notions in women's health and cardiovascular research are discussed. Also included are recommendations for future research to influence social change in women's cardiac health.

  11. Dental resin cure monitoring by inherent fluorescence (United States)

    Li, Qun; Zhou, Jack X.; Li, Qingxiong; Wang, Sean X.


    It is demonstrated that the inherent fluorescence of a dental composite resin can be utilized to monitor the curing status, i.e. degree of conversion of the resin. The method does not require any sample preparation and is potentially very fast for real time cure monitoring. The method is verified by Raman spectroscopy analysis.

  12. Harnessing Collective Knowledge Inherent in Tag Clouds (United States)

    Cress, U.; Held, C.


    Tagging systems represent the conceptual knowledge of a community. We experimentally tested whether people harness this collective knowledge when navigating through the Web. As a within-factor we manipulated people's prior knowledge (no knowledge vs. prior knowledge that was congruent/incongruent to the collective knowledge inherent in the tags).…

  13. Critical Social Theory: Core Tenets, Inherent Issues (United States)

    Freeman, Melissa; Vasconcelos, Erika Franca S.


    This chapter outlines the core tenets of critical social theory and describes inherent issues facing evaluators conducting critical theory evaluation. Using critical pedagogy as an example, the authors describe the issues facing evaluators by developing four of the subtheories that comprise a critical social theory: (a) a theory of false…

  14. Biological markers of oxidative stress: Applications to cardiovascular research and practice

    Directory of Open Access Journals (Sweden)

    Edwin Ho


    Full Text Available Oxidative stress is a common mediator in pathogenicity of established cardiovascular risk factors. Furthermore, it likely mediates effects of emerging, less well-defined variables that contribute to residual risk not explained by traditional factors. Functional oxidative modifications of cellular proteins, both reversible and irreversible, are a causal step in cellular dysfunction. Identifying markers of oxidative stress has been the focus of many researchers as they have the potential to act as an “integrator” of a multitude of processes that drive cardiovascular pathobiology. One of the major challenges is the accurate quantification of reactive oxygen species with very short half-life. Redox-sensitive proteins with important cellular functions are confined to signalling microdomains in cardiovascular cells and are not readily available for quantification. A popular approach is the measurement of stable by-products modified under conditions of oxidative stress that have entered the circulation. However, these may not accurately reflect redox stress at the cell/tissue level. Many of these modifications are “functionally silent”. Functional significance of the oxidative modifications enhances their validity as a proposed biological marker of cardiovascular disease, and is the strength of the redox cysteine modifications such as glutathionylation. We review selected biomarkers of oxidative stress that show promise in cardiovascular medicine, as well as new methodologies for high-throughput measurement in research and clinical settings. Although associated with disease severity, further studies are required to examine the utility of the most promising oxidative biomarkers to predict prognosis or response to treatment.

  15. 煤矿本质安全管理综合评价的SVM模型及应用%SVM Model for Comprehensive Evaluation of Coal Mine Inherent Safety Management and Its Application

    Institute of Scientific and Technical Information of China (English)

    李斌; 王志军


    为评价煤矿本质安全管理水平,根据煤矿本质安全管理的内涵,构建了评价指标体系。鉴于目前评价方法主观设置指标权重的缺陷,考虑到支持向量机算法的诸多优势,建立了基于支持向量机的煤矿本质安全管理综合评价模型。根据以往煤矿本质安全管理评价资料,构建了学习样本。采用留一法交互校验表明,该评估方法具有较高的精度,且无需人为设置指标权重,避免了人的主观因素对评价结果的影响,能够更客观、准确地得出评价结果。应用SVM模型对煤矿本质安全管理进行综合评价,可以将定性的问题进行定量评价,合理地反映煤矿本质安全管理的现状,有利于监管部门评价煤矿安全管理水平和企业内部的评比及管理,对建立煤矿安全管理机制具有重要作用。%An evaluation index system was constituted according to the connotation of the mine inherent safety management in order to evaluate the level of the mine inherent safety management. In view of the disadvantage of subjectively setting the index weight in the current evaluation method and in consideration of many advantages of the support vector machine algorithm, an integrated evaluation model for coal mine inherent safety management was established based on the support vector machine. A learning sample was constructed according to the previous data of mine inherent safety management evaluation. The cross validation with leave-one out of procedure showed this evaluation method had a high accuracy,need not to artificially set the index weight, can avoid the influence of the person's subjective factors on the evaluation results,and thus get objective and accurate evaluation results. When SVM model was used for the integrate evaluation of the mine inherent safety management system,the quantitative assessment can be done to a qualitative problem so as to rationally reflect the status of the mine

  16. Inherent Safety Characteristics of Advanced Fast Reactors (United States)

    Bochkarev, A. S.; Korsun, A. S.; Kharitonov, V. S.; Alekseev, P. N.


    The study presents SFR transient performance for ULOF events initiated by pump trip and pump seizure with simultaneous failure of all shutdown systems in both cases. The most severe cases leading to the pin cladding rupture and possible sodium boiling are demonstrated. The impact of various features on SFR inherent safety performance for ULOF events was analysed. The decrease in hydraulic resistance of primary loop and increase in primary pump coast down time were investigated. Performing analysis resulted in a set of recommendations to varying parameters for the purpose of enhancing the inherent safety performance of SFR. In order to prevent the safety barrier rupture for ULOF events the set of thermal hydraulic criteria defining the ULOF transient processes dynamics and requirements to these criteria were recommended based on achieved results: primary sodium flow dip under the natural circulation asymptotic level and natural circulation rise time.

  17. The inherent ethics and integrity of education


    Godon, Rafal; Hogan, Padraig


    The paper begins with some introductory remarks that explain why understanding education as a coherent human practice is necessary for a proper account of ethics in the field of education. The authors take three steps: presenting education as a practice in its own right, discussing the concept of thinking in the context of educational practice and finally revealing some practical consequences of the inherent ethics of education. The paper invites readers to further investigatio...

  18. Mechanisms of greater cardiomyocyte functions on conductive nanoengineered composites for cardiovascular applications

    Directory of Open Access Journals (Sweden)

    Stout DA


    Full Text Available David A Stout,1,2 Jennie Yoo,2 Adriana Noemi Santiago-Miranda,3 Thomas J Webster1,41School of Engineering, 2Division of Biology and Medicine, Brown University, Providence, RI, 3Department of Chemical Engineering, University of Puerto Rico, Mayagües, PR, 4Department of Orthopedics, Brown University, Providence, RI, USABackground: Recent advances in nanotechnology (materials with at least one dimension between 1 nm and 100 nm have led to the use of nanomaterials in numerous medical device applications. Recently, nanomaterials have been used to create innovative biomaterials for cardiovascular applications. Specifically, carbon nanofibers (CNF embedded in poly(lactic-co-glycolic-acid (PLGA have been shown to promote cardiomyocyte growth compared with conventional polymer substrates, but the mechanisms involved in such events remain unknown. The aim of this study was to determine the basic mechanism of cell growth on these novel nanocomposites.Methods: CNF were added to biodegradable PLGA (50:50 PGA:PLA weight ratio to increase the conductivity, mechanical and cytocompatibility properties of pure PLGA. For this reason, different PLGA to CNF ratios (100:0, 75:25, 50:50, 25:75, and 0:100 wt% with different PLGA densities (0.1, 0.05, 0.025, and 0.0125 g/mL were used, and their compatibility with cardiomyocytes was assessed.Results: Throughout all the cytocompatibility experiments, cardiomyocytes were viable and expressed important biomarkers, including cardiac troponin T, connexin-43, and alpha-sarcomeric actin (α-SCA. Adhesion and proliferation experiments indicated that a PLGA density of 0.025 g/mL with a PLGA to CNF ratio of 75:25 and 50:50 (wt% promoted the best overall cell growth, ie, a 55% increase in cardiomyocyte density after 120 hours compared with pure PLGA and a 75% increase compared with the control at the same time point for 50:50 (wt%. The PLGA:CNF materials were conductive, and their conductivity increased as greater amounts of CNF

  19. Inherent safety key performance indicators for hydrogen storage systems. (United States)

    Landucci, Gabriele; Tugnoli, Alessandro; Cozzani, Valerio


    The expected inherent safety performance of hydrogen storage technologies was investigated. Reference schemes were defined for alternative processes proposed for hydrogen storage, and several storage potentialities were considered. The expected safety performance of alternative process technologies was explored estimating key performance indicators based on consequence assessment and credit factors of possible loss of containment events. The results indicated that the potential hazard is always lower for the innovative technologies proposed for hydrogen storage, as metal or complex hydrides. This derived mainly from the application of the inherent safety principles of "substitution" and "moderation", since in these processes hydrogen is stored as a less hazardous hydride. However, the results also evidenced that in the perspective of an industrial implementation of these technologies, the reliability of the auxiliary equipment will be a critical issue to be addressed.

  20. Application of Data Mining techniques to relate Cardiovascular Risk and Coronary Calcium (United States)

    Lujan, F. N.; Cymberknop, L. J.; Alfonso, M.; Legnani, W.; Armentano Feijoo, R.


    Introduction: Knowledge Discovery in Databases (KDD) constitutes a process that allows data sets to be modeled and analyzed in an automated and exploratory manner. In this sense, data mining can be considered the main core of this procedure. Objective: In this study, a classification of clinical subjects (cluster) based on the comparison of parameters associated to cardiovascular risk factors was performed by means of KDD-based algorithms. Materials and Methods: the K-means algorithm, Hierarchical Agglomerative Clustering and Kohonen’s Self-organizing Maps were applied to the database in order to obtain relationships based on the dissimilarity of its constitutive fields. Results: Four different clusters were obtained, represented by a group of well-defined clustering rules. Conclusion: KDD can be used to extract relevant data from clinical databases, which are strongly correlated with well-known cardiovascular risk markers.

  1. Inherent randomicity in 4-symbolic dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Yagang [Department of Applied Mathematics, School of Mathematics and Physics, North China Electric Power University, Box 235, Baoding, Hebei 071003 (China); Center for Nonlinear Complex Systems, Department of Physics, Yunnan University, Kunming, Yunnan 650091 (China); E-mail:; Wang Changjiang [Department of Physics, Yunnan University, Kunming, Yunnan 650091 (China); Zhou Zhong [Center for Nonlinear Complex Systems, Department of Physics, Yunnan University, Kunming, Yunnan 650091 (China)


    The inherent randomicity in 4-symbolic dynamics will be clarified in this paper. The symbolic sequences bear three characteristics. The distribution of frequency, inter-occurrence times and the alignment of two random sequences are amplified in detail. By using transfer probability of Markov chain (MC), we obtain analytic expressions of generating functions in four probabilities stochastic wander model, which can be applied to all 4-symbolic systems. We hope to offer a symbolic platform that satisfies these stochastic properties and to study some properties of DNA sequences.

  2. Prevention of domino effect: from active and passive strategies to inherently safer design. (United States)

    Cozzani, Valerio; Tugnoli, Alessandro; Salzano, Ernesto


    The possible application of an inherent safety approach to the prevention of domino accidents was explored. The application of the inherent safety guidewords to the definition of effective actions for the prevention of domino events was analyzed. Due to the constraints originated by the conventional approach to process design, the "limitation of effects" guideword resulted the more effective in the identification of inherent safety actions to avoid domino events. Detailed design criteria for the improvement of layout in the framework of inherent safety were identified and discussed. Simple rules of thumbs were obtained for the preliminary assessment of safety distances and of critical inventories with respect to the escalation of fires and explosions. The results evidenced that the integration of inherent safety criteria with conventional passive or active protections seems a promising route for the prevention of severe domino accidental scenarios in chemical and process plants.

  3. Inherently safe in situ uranium recovery.

    Energy Technology Data Exchange (ETDEWEB)

    Krumhansl, James Lee; Beauheim, Richard Louis; Brady, Patrick Vane; Arnold, Bill Walter; Kanney, Joseph F.; McKenna, Sean Andrew


    Expansion of uranium mining in the United States is a concern to some environmental groups and sovereign Native American Nations. An approach which may alleviate some problems is to develop inherently safe in situ uranium recovery ('ISR') technologies. Current ISR technology relies on chemical extraction of trace levels of uranium from aquifers that, once mined, can still contain dissolved uranium and other trace metals that are a health concern. Existing ISR operations are few in number; however, high uranium prices are driving the industry to consider expanding operations nation-wide. Environmental concerns and enforcement of the new 30 ppb uranium drinking water standard may make opening new mining operations more difficult and costly. Here we propose a technological fix: the development of inherently safe in situ recovery (ISISR) methods. The four central features of an ISISR approach are: (1) New 'green' leachants that break down predictably in the subsurface, leaving uranium, and associated trace metals, in an immobile form; (2) Post-leachant uranium/metals-immobilizing washes that provide a backup decontamination process; (3) An optimized well-field design that increases uranium recovery efficiency and minimizes excursions of contaminated water; and (4) A combined hydrologic/geochemical protocol for designing low-cost post-extraction long-term monitoring. ISISR would bring larger amounts of uranium to the surface, leave fewer toxic metals in the aquifer, and cost less to monitor safely - thus providing a 'win-win-win' solution to all stakeholders.

  4. Is human fracture hematoma inherently angiogenic?

    LENUS (Irish Health Repository)

    Street, J


    This study attempts to explain the cellular events characterizing the changes seen in the medullary callus adjacent to the interfragmentary hematoma during the early stages of fracture healing. It also shows that human fracture hematoma contains the angiogenic cytokine vascular endothelial growth factor and has the inherent capability to induce angiogenesis and thus promote revascularization during bone repair. Patients undergoing emergency surgery for isolated bony injury were studied. Raised circulating levels of vascular endothelial growth factor were seen in all injured patients, whereas the fracture hematoma contained significantly higher levels of vascular endothelial growth factor than did plasma from these injured patients. However, incubation of endothelial cells in fracture hematoma supernatant significantly inhibited the in vitro angiogenic parameters of endothelial cell proliferation and microtubule formation. These phenomena are dependent on a local biochemical milieu that does not support cytokinesis. The hematoma potassium concentration is cytotoxic to endothelial cells and osteoblasts. Subcutaneous transplantation of the fracture hematoma into a murine wound model resulted in new blood vessel formation after hematoma resorption. This angiogenic effect is mediated by the significant concentrations of vascular endothelial growth factor found in the hematoma. This study identifies an angiogenic cytokine involved in human fracture healing and shows that fracture hematoma is inherently angiogenic. The differences between the in vitro and in vivo findings may explain the phenomenon of interfragmentary hematoma organization and resorption that precedes fracture revascularization.

  5. Sensors and actuators inherent in biological species (United States)

    Taya, Minoru; Stahlberg, Rainer; Li, Fanghong; Zhao, Ying Joyce


    This paper addresses examples of sensing and active mechanisms inherent in some biological species where both plants and animals cases are discussed: mechanosensors and actuators in Venus Fly Trap and cucumber tendrils, chemosensors in insects, two cases of interactions between different kingdoms, (i) cotton plant smart defense system and (ii) bird-of-paradise flower and hamming bird interaction. All these cases lead us to recognize how energy-efficient and flexible the biological sensors and actuators are. This review reveals the importance of integration of sensing and actuation functions into an autonomous system if we make biomimetic design of a set of new autonomous systems which can sense and actuate under a number of different stimuli and threats.

  6. Piezo1 Channels Are Inherently Mechanosensitive

    Directory of Open Access Journals (Sweden)

    Ruhma Syeda


    Full Text Available The conversion of mechanical force to chemical signals is critical for many biological processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels play a key role in sensing the mechanical stimuli experienced by various cell types and are present in organisms from bacteria to mammals. Bacterial mechanosensitive channels are characterized thoroughly, but less is known about their counterparts in vertebrates. Piezos have been recently established as ion channels required for mechanotransduction in disparate cell types in vitro and in vivo. Overexpression of Piezos in heterologous cells gives rise to large mechanically activated currents; however, it is unclear whether Piezos are inherently mechanosensitive or rely on alternate cellular components to sense mechanical stimuli. Here, we show that mechanical perturbations of the lipid bilayer alone are sufficient to activate Piezo channels, illustrating their innate ability as molecular force transducers.

  7. Human organ markets and inherent human dignity. (United States)

    MacKellar, Calum


    It has been suggested that human organs should be bought and sold on a regulated market as any other material property belongingto an individual. This would have the advantage of both addressing the grave shortage of organs available for transplantation and respecting the freedom of individuals to choose to do whatever they want with their body parts. The old arguments against such a market in human organs are, therefore, being brought back into question. The article examines the different arguments both in favour and against the sale of human organs. It concludes that the body and any of its elements is a full expression of the whole person. As such, they cannot have a price if the individual is to retain his or her full inherent dignity and if society is to retain and protect this very important concept.

  8. Inherently safe in situ uranium recovery (United States)

    Krumhansl, James L; Brady, Patrick V


    An in situ recovery of uranium operation involves circulating reactive fluids through an underground uranium deposit. These fluids contain chemicals that dissolve the uranium ore. Uranium is recovered from the fluids after they are pumped back to the surface. Chemicals used to accomplish this include complexing agents that are organic, readily degradable, and/or have a predictable lifetime in an aquifer. Efficiency is increased through development of organic agents targeted to complexing tetravalent uranium rather than hexavalent uranium. The operation provides for in situ immobilization of some oxy-anion pollutants under oxidizing conditions as well as reducing conditions. The operation also artificially reestablishes reducing conditions on the aquifer after uranium recovery is completed. With the ability to have the impacted aquifer reliably remediated, the uranium recovery operation can be considered inherently safe.

  9. Application of microwave sensor technology in cardiovascular disease for plaque detection

    Directory of Open Access Journals (Sweden)

    Wagner David


    Full Text Available Arteriosclerosis and associated cardiovascular disease remains the leading cause of mortality. Improved methods for vascular plaque detection allow early diagnose and better therapeutic options. Present diagnostic tools require intense technical expenditure and diminish value of modern screening methods. Our group developed an microwave sensor for on-site detection of plaque formation in arterial vessels. The sensor is an oscillator working around 27 GHz which is coupled to a microstrip stub line. The final flexible polyimid interposer has a length of 38 cm, a width of 1.2 mm and a thickness of 200 μm. Because of its minimal size the interposer completed a catheter with a diameter of 8F ready for further clinical use in cardiology and heart surgery.

  10. Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Stella Bernardi


    Full Text Available Cardiovascular diseases (CVD remain the major cause of death and premature disability in Western societies. Assessing the risk of CVD is an important aspect in clinical decision-making. Among the growing number of molecules that are studied for their potential utility as CVD biomarkers, a lot of attention has been focused on osteoprotegerin (OPG and its ligands, which are receptor activator of nuclear factor κB ligand (RANKL and TNF-related apoptosis-inducing ligand. Based on the existing literature and on our experience in this field, here we review what the possible roles of OPG and TRAIL in CVD are and their potential utility as CVD biomarkers.


    Kelli, Heval Mohamed; Witbrodt, Bradley; Shah, Amit


    Mobile health (mHealth) is the utilisation of mobile technologies in healthcare and has particular relevance in improving lifestyle behaviours which may ultimately reduce cardiovascular disease risk. Various intervention studies for example integrate self-monitoring of diet and physical activity with text messaging systems to improve intermediate outcomes. Currently the future progress of mHealth technologies in formal diagnostic and therapeutic roles is pending and includes the need to validate and standardise accelerometer and heart rate data from various devices. Data also needs to be integrated from such devices into the medical record system to facilitate communication between providers and patients. Although short-term behaviour changes have been found with technologies such as Fitbit® (Fitbit, Inc., San Francisco, California, USA), whether such technologies/interventions lead to sustained behaviour change and reduced risk of myocardial infarction and death remains to be seen.

  12. The Potential Therapeutic Application of Peptides and Peptidomimetics in Cardiovascular Disease. (United States)

    Recio, Carlota; Maione, Francesco; Iqbal, Asif J; Mascolo, Nicola; De Feo, Vincenzo


    Cardiovascular disease (CVD) remains a leading cause of mortality and morbidity worldwide. Numerous therapies are currently under investigation to improve pathological cardiovascular complications, but yet, there have been very few new medications approved for intervention/treatment. Therefore, new approaches to treat CVD are urgently required. Attempts to prevent vascular complications usually involve amelioration of contributing risk factors and underlying processes such as inflammation, obesity, hyperglycaemia, or hypercholesterolemia. Historically, the development of peptides as therapeutic agents has been avoided by the Pharmaceutical industry due to their low stability, size, rate of degradation, and poor delivery. However, more recently, resurgence has taken place in developing peptides and their mimetics for therapeutic intervention. As a result, increased attention has been placed upon using peptides that mimic the function of mediators involved in pathologic processes during vascular damage. This review will provide an overview on novel targets and experimental therapeutic approaches based on peptidomimetics for modulation in CVD. We aim to specifically examine apolipoprotein A-I (apoA-I) and apoE mimetic peptides and their role in cholesterol transport during atherosclerosis, suppressors of cytokine signaling (SOCS)1-derived peptides and annexin-A1 as potent inhibitors of inflammation, incretin mimetics and their function in glucose-insulin tolerance, among others. With improvements in technology and synthesis platforms the future looks promising for the development of novel peptides and mimetics for therapeutic use. However, within the area of CVD much more work is required to identify and improve our understanding of peptide structure, interaction, and function in order to select the best targets to take forward for treatment.

  13. Welding Distortion Prediction in 5A06 Aluminum Alloy Complex Structure via Inherent Strain Method

    Directory of Open Access Journals (Sweden)

    Zhi Zeng


    Full Text Available Finite element (FE simulation with inherent deformation is an ideal and practical computational approach for predicting welding stress and distortion in the production of complex aluminum alloy structures. In this study, based on the thermal elasto-plastic analysis, FE models of multi-pass butt welds and T-type fillet welds were investigated to obtain the inherent strain distribution in a 5A06 aluminum alloy cylindrical structure. The angular distortion of the T-type joint was used to investigate the corresponding inherent strain mechanism. Moreover, a custom-designed experimental system was applied to clarify the magnitude of inherent deformation. With the mechanism investigation of welding-induced buckling by FE analysis using inherent deformation, an application for predicting and mitigating the welding buckling in fabrication of complex aluminum alloy structure was developed.

  14. Cardiovascular disease risk score prediction models for women and its applicability to Asians

    Directory of Open Access Journals (Sweden)

    Goh LGH


    Full Text Available Louise GH Goh,1 Satvinder S Dhaliwal,1 Timothy A Welborn,2 Peter L Thompson,2–4 Bruce R Maycock,1 Deborah A Kerr,1 Andy H Lee,1 Dean Bertolatti,1 Karin M Clark,1 Rakhshanda Naheed,1 Ranil Coorey,1 Phillip R Della5 1School of Public Health, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia; 2Sir Charles Gairdner Hospital, Nedlands, Perth, WA, Australia; 3School of Population Health, University of Western Australia, Perth, WA, Australia; 4Harry Perkins Institute for Medical Research, Perth, WA, Australia; 5School of Nursing and Midwifery, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia Purpose: Although elevated cardiovascular disease (CVD risk factors are associated with a higher risk of developing heart conditions across all ethnic groups, variations exist between groups in the distribution and association of risk factors, and also risk levels. This study assessed the 10-year predicted risk in a multiethnic cohort of women and compared the differences in risk between Asian and Caucasian women. Methods: Information on demographics, medical conditions and treatment, smoking behavior, dietary behavior, and exercise patterns were collected. Physical measurements were also taken. The 10-year risk was calculated using the Framingham model, SCORE (Systematic COronary Risk Evaluation risk chart for low risk and high risk regions, the general CVD, and simplified general CVD risk score models in 4,354 females aged 20–69 years with no heart disease, diabetes, or stroke at baseline from the third Australian Risk Factor Prevalence Study. Country of birth was used as a surrogate for ethnicity. Nonparametric statistics were used to compare risk levels between ethnic groups. Results: Asian women generally had lower risk of CVD when compared to Caucasian women. The 10-year predicted risk was, however, similar between Asian and Australian women, for some models. These findings were

  15. Coblation tonsillectomy: is it inherently bloody? (United States)

    Khan, I; Abelardo, E; Scott, N W; Shakeel, M; Menakaya, O; Jaramillo, M; Mahmood, K


    The aim of the study was to compare a single surgeon's post-tonsillectomy haemorrhage rates using cold steel dissection and coblation tonsillectomy techniques. Retrospective study on patients, who underwent tonsillectomy at West Wales General Hospital (WWGH) performed by a single surgeon from 2006 to 2010 employing both cold steel and coblation tonsillectomies. Data were analysed using Mann-Whitney and Chi-squared tests. The nominated surgeon performed 239 tonsillectomies at WWGH from 2006 to 2010. 119 patients underwent cold steel dissection and 120 had coblation tonsillectomy. There was no demographic difference between the two groups. There was no statistically significant difference in the length of hospital stay between the two groups (median 1 day in each group). 6/119 (5.0%) patients in the cold steel group, and 7/120 (5.8%) in the coblation group had post-operative bleeding (p = 1.00). The return to theatre rate for cold steel dissection was 1/119 (0.84%) and for coblation surgery was 1/120 (0.83%) (p = 1.00). Among the first 60 cases of coblation tonsillectomies, 4 patients (6.6%) had post-operative haemorrhage and the latter 60 cases had 3 patients (5%). There was no evidence of a difference in the overall post-operative bleeding between those who had cold steel dissection and coblation tonsillectomies. These data suggest that higher post-operative haemorrhage is not inherent to coblation tonsillectomy.

  16. Conceptual design of inherently safe integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. I.; Chang, M. H.; Lee, D. J. and others


    The design concept of a 300 MWt inherently safe integral reactor(ISIR) for the propulsion of extra large and superhigh speed container ship was developed in this report. The scope and contents of this report are as follows : 1. The state of the art of the technology for ship-mounted reactor 2. Design requirements for ISIR 3. Fuel and core design 4. Conceptual design of fluid system 5. Conceptual design of reactor vessel assembly and primary components 6. Performance analyses and safety analyses. Installation of two ISIRs with total thermal power of 600MWt and efficiency of 21% is capable of generating shaft power of 126,000kW which is sufficient to power a container ship of 8,000TEU with 30knot cruise speed. Larger and speedier ship can be considered by installing 4 ISIRs. Even though the ISIR was developed for ship propulsion, it can be used also for a multi-purpose nuclear power plant for electricity generation, local heating, or seawater desalination by mounting on a movable floating barge. (author)

  17. A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Xia Wang


    Full Text Available Background. Clinical trials reveal that multiherb prescriptions of herbal medicine often exhibit pharmacological and therapeutic superiority in comparison to isolated single constituents. However, the synergistic mechanisms underlying this remain elusive. To address this question, a novel systems biology model integrating oral bioavailability and drug-likeness screening, target identification, and network pharmacology method has been constructed and applied to four clinically widely used herbs Radix Astragali Mongolici, Radix Puerariae Lobatae, Radix Ophiopogonis Japonici, and Radix Salviae Miltiorrhiza which exert synergistic effects of combined treatment of cardiovascular disease (CVD. Results. The results show that the structural properties of molecules in four herbs have substantial differences, and each herb can interact with significant target proteins related to CVD. Moreover, the bioactive ingredients from different herbs potentially act on the same molecular target (multiple-drug-one-target and/or the functionally diverse targets but with potentially clinically relevant associations (multiple-drug-multiple-target-one-disease. From a molecular/systematic level, this explains why the herbs within a concoction could mutually enhance pharmacological synergy on a disease. Conclusions. The present work provides a new strategy not only for the understanding of pharmacological synergy in herbal medicine, but also for the rational discovery of potent drug/herb combinations that are individually subtherapeutic.

  18. HDL-S1P: cardiovascular functions, disease-associated alterations, and therapeutic applications. (United States)

    Levkau, Bodo


    Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid contained in High-density lipoproteins (HDL) and has drawn considerable attention in the lipoprotein field as numerous studies have demonstrated its contribution to several functions inherent to HDL. Some of them are partly and some entirely due to the S1P contained in HDL (HDL-S1P). Despite the presence of over 1000 different lipids in HDL, S1P stands out as it possesses its own cell surface receptors through which it exercises key physiological functions. Most of the S1P in human plasma is associated with HDL, and the amount of HDL-S1P influences the quality and quantity of HDL-dependent functions. The main binding partner of S1P in HDL is apolipoprotein M but others may also exist particularly under conditions of acute S1P elevations. HDL not only exercise functions through their S1P content but have also an impact on genuine S1P signaling by influencing S1P bioactivity and receptor presentation. HDL-S1P content is altered in human diseases such as atherosclerosis, coronary artery disease, myocardial infarction, renal insufficiency and diabetes mellitus. Low HDL-S1P has also been linked to impaired HDL functions associated with these disorders. Although the pathophysiological and molecular reasons for such disease-associated shifts in HDL-S1P are little understood, there have been successful approaches to circumvent their adverse implications by pharmacologically increasing HDL-S1P as means to improve HDL function. This mini-review will cover the current understanding of the contribution of HDL-S1P to physiological HDL function, its alteration in disease and ways for its restoration to correct HDL dysfunction.

  19. Measurement of inherent optical properties in the Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Suresh, T.; Desa, E.; Kurian, J.; Mascarenhas, A.A.M.Q.

    Inherent optical properties, absorption and began attenuation were measured in situ using a reflective tube absorption meter at nint wavelength, 412, 440, 488, 510, 555, 630, 650, 676 and 715 nm, in the Arabian Sea during March. Since inherent...

  20. [Use of the thermal laser effect of laser irradiation for cardiovascular applications exemplified by the Nd:YAG laser]. (United States)

    Ischinger, T; Coppenrath, K; Weber, H; Enders, S; Unsöld, E; Hessel, S


    Techniques of percutaneous transluminal application of laser energy for vessel recanalization have been used clinically since 1983. The commonly used Nd:YAG and argon lasers achieve ablation of atherosclerotic plaques by thermal action (vaporization). In order to reduce undesirable thermal damage in the neighborhood of the target tissue and to avoid vessel perforation, optimal irradiation parameters, modified (atraumatic) fiber tips (hot tips, sapphires), and steerable catheter systems needed to be implemented. Favorable results from peripheral application have encouraged use in the coronary circulation. More recently, coagulative tissue effects of circumferential irradiation of the vessel wall during balloon dilatation have been used for stabilization of acute and late results after mechanical balloon angioplasty. Enhancement of the differential light absorption of atherosclerotic plaque by use of biological dyes may further improve selective intravascular laser application. Intraoperative ECG-guided laser coagulation of arrhythmogenic areas of myocardium is a method for treatment of malignant arrhythmias. Transluminal non-operative application of myocardial laser photocoagulation has now been tested experimentally and shown to be safe and effective. There was no arrhythmogenicity or thermal damage of coronary arteries associated with this method. Innovative techniques such as nanosecond pulsed excimer lasers (athermal action) and development of "intelligent" lasers--which are equipped with spectroscopy-guided feedback systems for plaque recognition--have opened new perspectives and will further improve safety and efficacy of clinical laser application. However, according to current experience, the thermally acting Nd:YAG laser is an effective and versatile mode of laser therapy for selected cardiovascular indications.

  1. Introduction: Cardiovascular physics. (United States)

    Wessel, Niels; Kurths, Jürgen; Ditto, William; Bauernschmitt, Robert


    The number of patients suffering from cardiovascular diseases increases unproportionally high with the increase of the human population and aging, leading to very high expenses in the public health system. Therefore, the challenge of cardiovascular physics is to develop high-sophisticated methods which are able to, on the one hand, supplement and replace expensive medical devices and, on the other hand, improve the medical diagnostics with decreasing the patient's risk. Cardiovascular physics-which interconnects medicine, physics, biology, engineering, and mathematics-is based on interdisciplinary collaboration of specialists from the above scientific fields and attempts to gain deeper insights into pathophysiology and treatment options. This paper summarizes advances in cardiovascular physics with emphasis on a workshop held in Bad Honnef, Germany, in May 2005. The meeting attracted an interdisciplinary audience and led to a number of papers covering the main research fields of cardiovascular physics, including data analysis, modeling, and medical application. The variety of problems addressed by this issue underlines the complexity of the cardiovascular system. It could be demonstrated in this Focus Issue, that data analyses and modeling methods from cardiovascular physics have the ability to lead to significant improvements in different medical fields. Consequently, this Focus Issue of Chaos is a status report that may invite all interested readers to join the community and find competent discussion and cooperation partners.

  2. Distribution of Longitudinal Inherent Strains in Multiple-passes Welding

    Institute of Scientific and Technical Information of China (English)

    Peng HE; Jiuhai ZHANG; Toshio Terasaki; Testuya Akiyama


    A fundamental theory for the analysis of residual welding stresses and deformation based on the inherent strain distribution along the welded joint is introduced. The computing method of distribution of longitudinal inherent strains in multiple-passes welding in heavy plate weldment is proposed. Distribution of longitudinal inherent strains in one-pass welding and two-passes welding are compared and analyzed. The effect of cutting on inherent strain is discussed.

  3. Food plant toxicants and safety - Risk assessment and regulation of inherent toxicants in plant foods

    DEFF Research Database (Denmark)

    Essers, A.J.A.; Alink, G.M.; Speijers, G.J.A.


    The ADI as a tool for risk management and regulation of food additives and pesticide residues is not readily applicable to inherent food plant toxicants: The margin between actual intake and potentially toxic levels is often small; application of the default uncertainty factors used to derive ADI...... values, particularly when extrapolating from animal data, would prohibit the utilisation of the food, which may have an overall beneficial health effect. Levels of inherent toxicants are difficult to control; their complete removal is not always wanted, due to their function for the plant or for human...... health. The health impact of the inherent toxicant is often modified by factors in the food, e.g. the bioavailability from the matrix and interaction with other inherent constituents. Risk-benefit analysis should be made for different consumption scenarios, without the use of uncertainty factors. Crucial...

  4. Inherently fluorescent polystyrene microspheres for coating, sensing and cellular imaging. (United States)

    Qu, Jian-Bo; Xu, Yu-Liang; Liu, Yu; Wang, Yanan; Sui, Yuanhong; Liu, Jian-Guo; Wang, Xiaojuan


    Commercially available polystyrene (PS) fluorescent microspheres are widely used in biological field for tracing, in vivo imaging and calibration of flow cytometry, among other applications. However, these particles do suffer from some drawbacks such as the leakage and photobleaching of organic dyes within them. In the present study, inherently fluorescent properties of PS based microspheres have been explored for the first time. Here we find that a simple chloromethylation reaction endows the polystyrene particles with inherent fluorescence without any subsequent conjugation of an external fluorophore. A possible mechanism for fluorescence is elucidated by synthesizing and investigating p-ethylbenzyl chloride, a compound with similar structure. Significantly, no photobleaching or leaking issues were observed owing to the stable structure of the microspheres. Chloromethylated PS (CMPS) microspheres can keep their perpetual blue fluorescence even in dry powder state making them attractive as a potential coating material. Furthermore, the chloromethyl groups on CMPS microspheres make them very convenient for further functionalization. Poly(ethylene glycol) (PEG) grafted microspheres showed good biocompatibility and negligible cytotoxicity, and could be used to image intracellular Fe(3+) due to the selective fluorescence quenching effect of aqueous Fe(3+) in cytoplasm.

  5. "Beauty is a light in the heart": the transformative potential of optogenetics for clinical applications in cardiovascular medicine. (United States)

    Boyle, Patrick M; Karathanos, Thomas V; Trayanova, Natalia A


    Optogenetics is an exciting new technology in which viral gene or cell delivery is used to inscribe light sensitivity in excitable tissue to enable optical control of bioelectric behavior. Initial progress in the fledgling domain of cardiac optogenetics has included in vitro expression of various light-sensitive proteins in cell monolayers and transgenic animals to demonstrate an array of potentially useful applications, including light-based pacing, silencing of spontaneous activity, and spiral wave termination. In parallel to these developments, the cardiac modeling community has developed a versatile computational framework capable of realistically simulating optogenetics in biophysically detailed, patient-specific representations of the human heart, enabling the exploration of potential clinical applications in a predictive virtual platform. Toward the ultimate goal of assessing the feasibility and potential impact of optogenetics-based therapies in cardiovascular medicine, this review provides (1) a detailed synopsis of in vivo, in vitro, and in silico developments in the field and (2) a critical assessment of how existing clinical technology for gene/cell delivery and intra-cardiac illumination could be harnessed to achieve such lofty goals as light-based arrhythmia termination.

  6. Cardiovascular modeling and diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Kangas, L.J.; Keller, P.E.; Hashem, S.; Kouzes, R.T. [Pacific Northwest Lab., Richland, WA (United States)


    In this paper, a novel approach to modeling and diagnosing the cardiovascular system is introduced. A model exhibits a subset of the dynamics of the cardiovascular behavior of an individual by using a recurrent artificial neural network. Potentially, a model will be incorporated into a cardiovascular diagnostic system. This approach is unique in that each cardiovascular model is developed from physiological measurements of an individual. Any differences between the modeled variables and the variables of an individual at a given time are used for diagnosis. This approach also exploits sensor fusion to optimize the utilization of biomedical sensors. The advantage of sensor fusion has been demonstrated in applications including control and diagnostics of mechanical and chemical processes.

  7. Myocardial tagging by Cardiovascular Magnetic Resonance: evolution of techniques--pulse sequences, analysis algorithms, and applications

    Directory of Open Access Journals (Sweden)

    Ibrahim El-Sayed H


    Full Text Available Abstract Cardiovascular magnetic resonance (CMR tagging has been established as an essential technique for measuring regional myocardial function. It allows quantification of local intramyocardial motion measures, e.g. strain and strain rate. The invention of CMR tagging came in the late eighties, where the technique allowed for the first time for visualizing transmural myocardial movement without having to implant physical markers. This new idea opened the door for a series of developments and improvements that continue up to the present time. Different tagging techniques are currently available that are more extensive, improved, and sophisticated than they were twenty years ago. Each of these techniques has different versions for improved resolution, signal-to-noise ratio (SNR, scan time, anatomical coverage, three-dimensional capability, and image quality. The tagging techniques covered in this article can be broadly divided into two main categories: 1 Basic techniques, which include magnetization saturation, spatial modulation of magnetization (SPAMM, delay alternating with nutations for tailored excitation (DANTE, and complementary SPAMM (CSPAMM; and 2 Advanced techniques, which include harmonic phase (HARP, displacement encoding with stimulated echoes (DENSE, and strain encoding (SENC. Although most of these techniques were developed by separate groups and evolved from different backgrounds, they are in fact closely related to each other, and they can be interpreted from more than one perspective. Some of these techniques even followed parallel paths of developments, as illustrated in the article. As each technique has its own advantages, some efforts have been made to combine different techniques together for improved image quality or composite information acquisition. In this review, different developments in pulse sequences and related image processing techniques are described along with the necessities that led to their invention

  8. Mechanical property, biocorrosion and in vitro biocompatibility evaluations of Mg-Li-(Al)-(RE) alloys for future cardiovascular stent application. (United States)

    Zhou, W R; Zheng, Y F; Leeflang, M A; Zhou, J


    Mg-Li-based alloys were investigated for future cardiovascular stent application as they possess excellent ductility. However, Mg-Li binary alloys exhibited reduced mechanical strengths due to the presence of lithium. To improve the mechanical strengths of Mg-Li binary alloys, aluminum and rare earth (RE) elements were added to form Mg-Li-Al ternary and Mg-Li-Al-RE quarternary alloys. In the present study, six Mg-Li-(Al)-(RE) alloys were fabricated. Their microstructures, mechanical properties and biocorrosion behavior were evaluated by using optical microscopy, X-ray diffraction, scanning electronic microscopy, tensile tests, immersion tests and electrochemical measurements. Microstructure characterization indicated that grain sizes were moderately refined by the addition of rare earth elements. Tensile testing showed that enhanced mechanical strengths were obtained, while electrochemical and immersion tests showed reduced corrosion resistance caused by intermetallic compounds distributed throughout the magnesium matrix in the rare-earth-containing Mg-Li alloys. Cytotoxicity assays, hemolysis tests as well as platelet adhesion tests were performed to evaluate in vitro biocompatibilities of the Mg-Li-based alloys. The results of cytotoxicity assays clearly showed that the Mg-3.5Li-2Al-2RE, Mg-3.5Li-4Al-2RE and Mg-8.5Li-2Al-2RE alloys suppressed vascular smooth muscle cell proliferation after 5day incubation, while the Mg-3.5Li, Mg-8.5Li and Mg-8.5Li-1Al alloys were proven to be tolerated. In the case of human umbilical vein endothelial cells, the Mg-Li-based alloys showed no significantly reduced cell viabilities except for the Mg-8.5Li-2Al-2RE alloy, with no obvious differences in cell viability between different culture periods. With the exception of Mg-8.5Li-2Al-2RE, all of the other Mg-Li-(Al)-(RE) alloys exhibited acceptable hemolysis ratios, and no sign of thrombogenicity was found. These in vitro experimental results indicate the potential of Mg

  9. A systematic review on the application of cardiovascular risk prediction models in pharmacoeconomics, with a focus on primary prevention

    NARCIS (Netherlands)

    Stevanovic, Jelena; Postma, Maarten J.; Pechlivanoglou, Petros


    Background: Long-term trials on the effectiveness of pharmacological treatment for primary cardiovascular disease prevention are scant. For that reason risk prediction models are used as a tool to project changes in cardiovascular disease incidence due to changes in risk factor levels observed in sh

  10. Cardiovascular issues in boxing and contact sports. (United States)

    Siegel, Stephen A


    Despite the inherent risks associated with exercise in general and boxing in particular, the sport has had a limited number of catastrophic cardiovascular events. Screening should be based on risks involved and become more extensive with the advancement of the athlete. Anatomic and electrophysiologic risks need to be assessed and may preclude participation with resultant life style and economic complications. There should be adequate preparation for the rare potential cardiovascular complication at all events, with the ability to rapidly assess and treat arrhythmias.

  11. Flexible low-cost cardiovascular risk marker biosensor for point-of-care applications

    KAUST Repository

    Sivashankar, S.


    The detection and quantification of protein on a laser written flexible substrate for point-of-care applications are described. A unique way of etching gold on polyethylene terephthalate (PET) substrate is demonstrated by reducing the damage that may be caused on PET sheets otherwise. On the basis of the quantity of the C-reactive protein (CRP) present in the sample, the risk of cardiac disease can be assessed. This hsCRP test is incorporated to detect the presence of CRP on a PET laser patterned biosensor. Concentrations of 1, 2, and 10 mg/l were chosen to assess the risk of cardiac diseases as per the limits set by the American Heart Association.

  12. [Comparison of the action of Cordemcura on selected cardiovascular parameters following intraduodenal and intravenous application in beagles]. (United States)

    Hübler, D; Mudhaffar, A A; Schilling, G; Elze, M; Chemnitius, K H


    The novel cardiotonic Cordemcura was tested for its cardiovascular effects after intraduodenal application to anaesthetized dogs. For this purpose, beagles received Cordemcura intraduodenally as a Tylose suspension, with 4 bolus injections (10(-5), 3 X 10(-5), 6 X 10(-5), and 10(-4) mol/kg) given at 30-min intervals. The test parameters used to analyze the onset of action and its course include: heart frequency (HFR), maximum rate of pressure rise (dp/dtmax) and decline (dp/dtmin) in the left ventricle, cardiac output (CO), stroke volume (SV), total peripheral resistance (TPR) and peripheral arterial blood pressure, systolic (Ps) and diastolic (Pd), and dose-effect curves determined for the individual test parameters. There was a dose-dependent increase of dp/dtmax up to a maximum of 130%, which 3 h afterwards was still about 60% above the initial value. The heart frequency, too, rose dose-dependently by a maximum of 80%, though not being significantly different from the initial value any longer 3 h after the last bolus injection. The Ps was slightly, but significantly decreased with the higher dose levels used. The influence on dp/dtmin and Pd was insignificant. A significant rise was found in the cardiac output, whereas the peripheral resistance showed a slight decline. After 3 h, a significant rise was still seen in the contractility (dp/dtmax), whereas the other parameters were no longer significantly different from the initial values. Moreover, selected dose levels of Cordemcura were tested after i. v. application, and a comparison was made of their effect on heart frequency, peripheral blood pressure, and inotropism. The importance of the findings was discussed.

  13. Application of cardiovascular disease risk prediction models and the relevance of novel biomarkers to risk stratification in Asian Indians

    Directory of Open Access Journals (Sweden)

    S Kanjilal


    Full Text Available S Kanjilal1, VS Rao1, M Mukherjee1, BK Natesha1, KS Renuka1, K Sibi1, SS Iyengar1, Vijay V Kakkar1,21Tata Proteomics and Coagulation Department, Thrombosis Research Institute, Bangalore, Narayana Hrudayalaya Hospital, Bangalore, Karnataka, India; 2Thrombosis Research Institute, London, UKAbstract: The increasing pressure on health resources has led to the emergence of risk assessment as an essential tool in the management of cardiovascular disease (CVD. Concern exists regarding the validity of their generalization to all populations. Existing risk scoring models do not incorporate emerging ‘novel’ risk factors. In this context, the aim of the study was to examine the relevance of British, European, and Framingham predictive CVD risk scores to the asymptomatic high risk Indian population. Blood samples drawn from the participants were analyzed for various ‘traditional’ and ‘novel’ biomarkers, and their CVD risk factor profiling was also done. The Framingham model defined only 5% of the study cohort to be at high risk, which appears to be an underestimation of CVD risk in this genetically predisposed population. These subjects at high risk had significantly elevated levels of lipid, pro-inflammatory, pro-thrombotic, and serological markers. It is more relevant to develop risk predictive scores for application to the Indian population. This study substantiates the argument that alternative approaches to risk stratification are required in order to make them more adaptable and applicable to different populations with varying risk factor and disease patterns.Keywords: atherosclerosis, risk factors, risk score, Framingham, plasma biomarkers

  14. Development of inherent core technologies for advanced reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Keung Koo; Noh, J.M.; Hwang, D.H. [and others


    Recently, the developed countries made their effort on developing the advanced reactor which will result in significantly enhanced safety and economy. However, they will protect the advanced reactor and its design technology with patent and proprietary right. Therefore, it is very important to develop our own key core concepts and inherent core design technologies which can form a foundation of indigenous technologies for development of the domestic advanced reactor in order to keep the superiority in the nuclear plant building market among the developing countries. In order to provide the basic technology for the core design of advanced reactor, this project is for developing the inherent core design concepts with enhanced safety and economy, and associated methodologies and technologies for core analyses. The feasibility study of constructing domestic critical facilities are performed by surveying the status and utilization of foreign facilities and by investigating the demand for domestic facilities. The research results developed in this project, such as core analysis methodologies for hexagonal core, conceptual core design based on hexagonal fuel assemblies and soluble boron core design and control strategies, will provide a technical foundation in developing core design of domestic advanced reactor. Furthermore, they will strengthen the competitiveness of Korean nuclear technology. We also expect that some of the design concepts developed in this project to improve the reactor safety and economy can be applicable to the design of advanced reactor. This will significantly reduce the public anxiety on the nuclear power plant, and will contribute to the economy of construction and operation for the future domestic reactors. Even though the critical facility will not be constructed right now, the investigation of the status and utilization of foreign critical facility will contribute to the future critical facility construction. (author). 150 refs., 34 tabs., 103

  15. Polymeric endoaortic paving: Mechanical, thermoforming, and degradation properties of polycaprolactone/polyurethane blends for cardiovascular applications. (United States)

    Ashton, J H; Mertz, J A M; Harper, J L; Slepian, M J; Mills, J L; McGrath, D V; Vande Geest, J P


    Polymeric endoaortic paving (PEAP) is a process by which a polymer is endovascularly delivered and thermoformed to coat or "pave" the lumen of the aorta. This method may offer an improvement to conventional endoaortic therapy in allowing conformal graft application with reduced risk of endoleak and customization to complex patient geometries. Polycaprolactone (PCL)/polyurethane (PU) blends of various blend ratios were assessed as a potential material for PEAP by characterizing their mechanical, thermoforming and degradation properties. Biaxial tension testing revealed that the blends' stiffness is similar to that of aortic tissue, is higher for blends with more PCL content, and may be affected by thermoforming and degradation. Tubes of blends were able to maintain a higher diameter increase after thermoforming at higher PCL content and higher heating temperatures; 50/50 blend tubes heated to 55 °C were able to maintain 90% of the diameter increase applied. Delamination forces of the blends ranged from 41 to 235 N m⁻². In a Pseudomonas lipase solution, the 50/50 blend had a 94% lower degradation rate than pure PCL, and the 10/90 blend exhibited no degradation. These results indicate that PEAP, consisting of a PCL/PU blend, may be useful in developing the next generation of endoaortic therapy.

  16. Cardiovascular pharmacogenetics. (United States)

    Myburgh, Renier; Hochfeld, Warren E; Dodgen, Tyren M; Ker, James; Pepper, Michael S


    Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical variation seen in response to pharmacotherapeutic drugs. This affects the likelihood of experiencing adverse drug reactions and also of achieving therapeutic success. In this paper, we review key studies in cardiovascular pharmacogenetics that reveal genetic variations underlying the outcomes of drug treatment in cardiovascular disease. Examples of genetic associations with drug efficacy and toxicity are described, including the roles of genetic variability in pharmacokinetics (e.g. drug metabolizing enzymes) and pharmacodynamics (e.g. drug targets). These findings have functional implications that could lead to the development of genetic tests aimed at minimizing drug toxicity and optimizing drug efficacy in cardiovascular medicine.

  17. Implementation of inherence calculus in the PowerLoom environment (United States)

    Wachulski, Marcin F.; Mulawka, Jan J.; Nieznański, Edward

    The article describes an attempt to implement abstract and concrete inherence calculi in the PowerLoom technology. Issues in the field of artificial intelligence, ontology and philosophy have been addressed. The inherence calculus is a type of a formal logic system. The PowerLoom technology consists of a knowledge representation language and an inference engine. Six inherence calculi have been implemented and an appropriate testing environment has been developed. The inherence calculus has been also extended by categorical properties and a theoretical discussion of ontological Boolean algebra has been conducted. Carried out experiments showed properties of the inherence calculi and also verified capabilities of PowerLoom to construct such logic systems. It occurred that expert system operational mode of PowerLoom outperforms its abilities to work as a mathematical theorem prover.

  18. Inherent Difference in Saliency for Generators with Different PM Materials

    Directory of Open Access Journals (Sweden)

    Sandra Eriksson


    Full Text Available The inherent differences between salient and nonsalient electrical machines are evaluated for two permanent magnet generators with different configurations. The neodymium based (NdFeB permanent magnets (PMs in a generator are substituted with ferrite magnets and the characteristics of the NdFeB generator and the ferrite generator are compared through FEM simulations. The NdFeB generator is a nonsalient generator, whereas the ferrite machine is a salient-pole generator, with small saliency. The two generators have almost identical properties at rated load operation. However, at overload the behaviour differs between the two generators. The salient-pole, ferrite generator has lower maximum torque than the NdFeB generator and a larger voltage drop at high current. It is concluded that, for applications where overload capability is important, saliency must be considered and the generator design adapted according to the behaviour at overload operation. Furthermore, if the maximum torque is the design criteria, additional PM mass will be required for the salient-pole machine.

  19. Design of a low-profile printed array of loaded dipoles with inherent frequency selectivity properties

    NARCIS (Netherlands)

    Cavallo, D.; Savoia, S.; Gerini, G.; Neto, A.; Galdi, V.


    This work presents the design of a low-profile array of printed dipoles with inherent filtering properties for radar applications. The antenna and the band-pass filter are integrated in a single module, which is small enough to fit within the array unit cell (with period of about 0.4 ? at the highes

  20. Impurities in Silicon Nanocrystals: The intentional and the inherent (United States)

    Rowe, David J.

    Silicon nanocrystals (SiNCs) have become an important class of materials in the fields of photovoltaics, thermoelectrics, lighting, and medicine. Impurities within SiNCs dramatically alter the electrical and optical properties of the host material, whether the impurity is intentionally added in an attempt to manipulate properties, or is inherent to the material and its natural state. Despite such remarkable changes, impurity incorporation within SiNCs remains poorly understood, since concepts applied to understanding impurities in bulk materials may not completely translate to nanomaterials. Understanding the effect of SiNC impurities requires new technologies to produce materials suitable for study combined with new insights to expound the differences in the nanoscale physics. Nonthermal plasma-assisted gas-phase synthesis provides an excellent route to producing and investigating impurities within SiNCs due to the unique chemical reaction environment of the plasma. The robustness of such a technique allows for the production of very pure SiNCs or SiNCs with added impurities simply by adding different chemicals to the plasma. The chapters in this document focus on the effect that different impurities have on the properties of SiNCs. Chapter 2 focuses on heavily P-doped SiNCs exhibiting the first known observation of a unique electrical and optical property known as localized surface plasmon resonance (LSPR) within free-standing SiNCs. Chapter 3 explains the synthesis of B- and P-doped SiGeNC alloys and their deposition into thin films for thermoelectric applications. Chapter 4 highlights research which uses P-doped SiNCs to form emitter layers for pn-junction type solar cells, including device fabrication and optical characterization. Chapter 5 examines inherent impurities in the form of dangling bond defects which may be responsible for the quenching of SiNC photoluminescence, and their evolution during the process of air-ambient oxidation. Several appendices at

  1. A systematic review on the application of cardiovascular risk prediction models in pharmacoeconomics, with a focus on primary prevention

    NARCIS (Netherlands)

    Stevanovic, J.; Postma, M.J.; Pechlivanoglou, P.


    OBJECTIVES: In the absence of long-term randomized clinical trials (RCTs) on the effectiveness of pharmacological treatment for primary cardiovascular disease (CVD) prevention, risk prediction models are used to project changes in CVD incidence due to changes on risk factor levels observed in short-

  2. Compact All Solid State Oceanic Inherent Optical Property Sensor Project (United States)

    National Aeronautics and Space Administration — This work concerns the development of a prototype of a Volume Scattering Function (VSF) sensor for measurement of this inherent optical property(IOP) of seawater....

  3. Compact All Solid State Oceanic Inherent Optical Property Sensor Project (United States)

    National Aeronautics and Space Administration — Light propagation in the sea and the consequent remote sensing signals seen by aircraft and spacecraft is fundamentally governed by the inherent optical properties...

  4. Coherence Inherent in an Incoherent Synchrotron Radio Source

    Indian Academy of Sciences (India)

    Ashok K. Singal


    We show that a partial coherence due to antenna mechanism can be inherently present in any compact synchrotron source, which resolves many long-standing problems in the spectra and variability of compact extragalactic radio sources.

  5. Inherently safe reactors and a second nuclear era. (United States)

    Weinberg, A M; Spiewak, I


    The Swedish PIUS reactor and the German-American small modular high-temperature gas-cooled reactor are inherently safe-that is, their safety relies not upon intervention of humans or of electromechanical devices but on immutable principles of physics and chemistry. A second nuclear era may require commercialization and deployment of such inherently safe reactors, even though existing light-water reactors appear to be as safe as other well-accepted sources of central electricity, particularly hydroelectric dams.


    Directory of Open Access Journals (Sweden)

    Manoj G Tyagi


    Full Text Available Vasopressin, a posterior pituitary hormone is responsible for water reabsorption by the kidneys and maintenance of cardio-vascular homeostasis. Vasopressin receptors are characterized as VR 1 (V1a, VR2 (V2, and VR3 (V1b. VR1, which is abundant in vascular smooth muscles, causes vasoconstriction by increasing intracellular calcium via the phosphatidylinositol bisphosphonate pathway and a positive inotropic effect in cardiac muscle. VR2 has also been shown to be expressed in the heart. There is emerging role for vasopressin receptors in health and disease. This study describes the application of Western blotting to elucidate the importance of vasopressin receptors in the heart cells.

  7. Application of cardiovascular disease risk prediction models and the relevance of novel biomarkers to risk stratification in Asian Indians


    S Kanjilal; Rao, VS; Mukherjee, M.; Natesha, BK; Renuka, KS; Sibi, K; Iyengar, SS; Kakkar, Vijay V


    The increasing pressure on health resources has led to the emergence of risk assessment as an essential tool in the management of cardiovascular disease (CVD). Concern exists regarding the validity of their generalization to all populations. Existing risk scoring models do not incorporate emerging ‘novel’ risk factors. In this context, the aim of the study was to examine the relevance of British, European, and Framingham predictive CVD risk scores to the asymptomatic high risk Indian populati...

  8. A multilevel model for cardiovascular disease prevalence in the US and its application to micro area prevalence estimates



    Abstract Background Estimates of disease prevalence for small areas are increasingly required for the allocation of health funds according to local need. Both individual level and geographic risk factors are likely to be relevant to explaining prevalence variations, and in turn relevant to the procedure for small area prevalence estimation. Prevalence estimates are of particular importance for major chronic illnesses such as cardiovascular disease. Methods A multilevel prevalence model for ca...

  9. Mathematical multi-scale model of the cardiovascular system including mitral valve dynamics. Application to ischemic mitral insufficiency

    Directory of Open Access Journals (Sweden)

    Moonen Marie


    Full Text Available Abstract Background Valve dysfunction is a common cardiovascular pathology. Despite significant clinical research, there is little formal study of how valve dysfunction affects overall circulatory dynamics. Validated models would offer the ability to better understand these dynamics and thus optimize diagnosis, as well as surgical and other interventions. Methods A cardiovascular and circulatory system (CVS model has already been validated in silico, and in several animal model studies. It accounts for valve dynamics using Heaviside functions to simulate a physiologically accurate "open on pressure, close on flow" law. However, it does not consider real-time valve opening dynamics and therefore does not fully capture valve dysfunction, particularly where the dysfunction involves partial closure. This research describes an updated version of this previous closed-loop CVS model that includes the progressive opening of the mitral valve, and is defined over the full cardiac cycle. Results Simulations of the cardiovascular system with healthy mitral valve are performed, and, the global hemodynamic behaviour is studied compared with previously validated results. The error between resulting pressure-volume (PV loops of already validated CVS model and the new CVS model that includes the progressive opening of the mitral valve is assessed and remains within typical measurement error and variability. Simulations of ischemic mitral insufficiency are also performed. Pressure-Volume loops, transmitral flow evolution and mitral valve aperture area evolution follow reported measurements in shape, amplitude and trends. Conclusions The resulting cardiovascular system model including mitral valve dynamics provides a foundation for clinical validation and the study of valvular dysfunction in vivo. The overall models and results could readily be generalised to other cardiac valves.

  10. Measurements of Pulmonary Artery Size for Assessment of Pulmonary Hypertension by Cardiovascular Magnetic Resonance and Clinical Application

    Directory of Open Access Journals (Sweden)

    Fan YANG


    Full Text Available Background and objective Pulmonary hypertension (PH often leads to dilatation of main pulmonary artery (MPA. MPA measurements can be used to predict PH. This aim of this study is to investigate power of MPA vessel indices, which are acquired from cardiovascular magnetic resonance, to evaluate PH. Methods Cardiovascular-magnetic-resonance-determined parameters of MPA were acquired and calculated in 83 PH patients, whose diagnosis were confirmed with right heart catheterization and 49 healthy volunteers; these parameters included MPA diameter (DPA, ratio of DPA and ascending aorta diameter (DPA/DAo, max mean diameter (MDmax, min mean diameter (MDmin, fraction transverse diameter (fTD, fraction longitudinal diameter (fLD, and distensibility. Results Compared with control group, DPA, DPA/DAo, MDmax, and MDmin were significantly higher in patients with PH (P28.4 mm, and MDmax>32.4 mm (area under the curve, AUC=0.979, 0.981 showed best performance in predicting PH, yielding highest specificity at 100%. Conclusion Noninvasive cardiovascular-magnetic-resonance-derived MPA measurements provide excellent and practical reference in clinical settings for detecting PH.

  11. Application of stem cell transplantation in treating cardiovascular diseases%干细胞移植治疗在心血管疾病中的应用

    Institute of Scientific and Technical Information of China (English)

    陈光辉; 夏菁; 刘宏斌


    决干细胞移植治疗中的重点及难点问题将为更加有效的预防及治疗心血管疾病提供强有力的理论及实践支持.%BACKGROUND: As a group of primary cells, stem cells have the potentials of self-renewal and multi-directional differentiation, and can replace the damaged cardiomyocytes to construct new vessels, and enable the asthenic heart to obtain the blood pumping function again. This study summarized the progress of stem cell transplantation in treating cardiovascular diseasesDATA SOURCES: A computer-based online search of Pubmed database was undertaken to identify English articles published from January 2000 to December 2005, the keywords were "stem cell transplantation, cardiovascular diseases".STUDY SELECTION: The articles were primarily checked, and the references of each literature were looked up. Inclusive criteria: articles correlated with the classification and the transplanted pathways of stem cells, the present status,problems and prospect of its basic and clinical application in treating cardiovascular diseases. Exclusive criteria: repetitive study or Meta analysis.DATA EXTRACTION: Totally 50 relative literatures were collected, and 31 of them accorded with the inclusive criteria,and the other 19 were excluded due to the old or repetitive contents. Of the 31 involved literatures, 19 were about the classification of stem cells used in cardiovascular system, 1 about the transplanted pathways of stem cells, 8 about the application of stem cells in treating cardiovascular diseases, and 3 about the existing problems and prospect.DATA SYNTHESIS: With the continuous improvement of living level and aging, cardiovascular diseases have become the main causes for death and disability in modern society. Stem cells have the potentials of multi-directional differentiation, and have become the main seed cells for cell replacement therapy, and provided important investigative and applicating field for the treatment of cardiovascular

  12. Thermally responsive polymer electrolytes for inherently safe electrochemical energy storage (United States)

    Kelly, Jesse C.

    Electrochemical double layer capacitors (EDLCs), supercapacitors and Li-ion batteries have emerged as premier candidates to meet the rising demands in energy storage; however, such systems are limited by thermal hazards, thermal runaway, fires and explosions, all of which become increasingly more dangerous in large-format devices. To prevent such scenarios, thermally-responsive polymer electrolytes (RPEs) that alter properties in electrochemical energy storage devices were designed and tested. These RPEs will be used to limit or halt device operation when temperatures increase beyond a predetermined threshold, therefore limiting further heating. The development of these responsive systems will offer an inherent safety mechanism in electrochemical energy storage devices, while preserving the performance, lifetimes, and versatility that large-format systems require. Initial work focused on the development of a model system that demonstrated the concept of RPEs in an electrochemical device. Aqueous electrolyte solutions of polymers exhibiting properties that change in response to temperature were developed for applications in EDLCs and supercapacitors. These "smart materials" provide a means to control electrochemical systems where polymer phase separation at high temperatures affects electrolyte properties and inhibits device performance. Aqueous RPEs were synthesized using N-isopropylacrylamide, which governs the thermal properties, and fractions of acrylic acid or vinyl sulfonic acids, which provide ions to the solution. The molecular properties of these aqueous RPEs, specifically the ionic composition, were shown to influence the temperature-dependent electrolyte properties and the extent to which these electrolytes control the energy storage characteristics of a supercapacitor device. Materials with high ionic content provided the highest room temperature conductivity and electrochemical activity; however, RPEs with low ionic content provided the highest "on

  13. On Four Ways against Cooperative Principle & Inherent Conversational Implicatures

    Institute of Scientific and Technical Information of China (English)



    By using methods of theoretical review,and example analysis,this paper aims at further analyzing Grice’s 4 ways of against the Cooperative Principle and inherent conversational implicatures in order to prove that once the Cooperative Principle is violated,the conversational implicatures arise.This will benefit the communicational practice.This paper finds out that any way against CP must cause conversational implicatures.There are limitations in this paper.It just covers the four ways of Grice introduced by Jiang Wangqi(2000),and inherent conversational implicatures found by the author.It might have other ways and implicatures as well.

  14. On Four Ways against Cooperative Principle& Inherent Conversational Implicatures

    Institute of Scientific and Technical Information of China (English)



    By using methods of theoretical review,and example analysis,this paper aims at further analyzing Grice’s 4 ways of against the Cooperative Principle and inherent conversational implicatures in order to prove that once the Cooperative Principle is violated,the conversational implicatures arise.This will benefit the communicational practice.This paper finds out that any way against CP must cause conversational implicatures.There are limitations in this paper.It just covers the four ways of Grice introduced by Jiang Wangqi(2000),and inherent conversational implicatures found by the author.It might have other ways and implicatures as well.

  15. Attenuated Realities: Pynchon's Trajectory from V. to Inherent Vice

    Directory of Open Access Journals (Sweden)

    Kathryn Hume


    Full Text Available Part of what established Pynchon as postmodern was his piling up of multiple realities. Hence, the surprise that 'Inherent Vice' retains only the most attenuated forms of such worlds alternative to our own. In earlier fiction, we find a world served by the Tristero postal system, a world inhabited by angels, by thanatoids and other forms of the dead, by Japanese film monsters, by giant vegetables. In Pynchon’s fictive realities, an airship can sail beneath desert sand or through the center of the globe via Symmes’s Hole, and the photograph of a corpse can be run backward in time to show its murderer. Up through 'Against the Day', Pynchon showered us with alternate realities that reached beyond the material world that most of us accept as 'alles, was der Fall ist'. 'Inherent Vice' departs from this vision. Has Pynchon simply grown up? Or grown old? Or is something else operating here? I will provide a brief taxonomy of Pynchon’s multiple worlds as characterized by paranoia, mysticism, religion, and humor and then analyze what remains of these in 'Inherent Vice'. Among the causes for his changed technique may be his choice of genre. The detective story is epistemological rather than ontological in its questions, so Pynchon concerns himself far more with what Doc Sportello can know than with making him navigate through multiple realities. I argue, however, that 'Inherent Vice' is surprisingly a worst-case scenario for Pynchon.

  16. Tactical supply chain planning models with inherent flexibility

    DEFF Research Database (Denmark)

    Esmaeilikia, Masoud; Fahimnia, Behnam; Sarkis, Joeseph


    Supply chains (SCs) can be managed at many levels. The use of tactical SC planning models with multiple flexibility options can help manage the usual operations efficiently and effectively, whilst improve the SC resiliency in response to inherent environmental uncertainties. This paper defines...

  17. Applicability of the ankle-brachial-index measurement as screening device for high cardiovascular risk: an observational study

    Directory of Open Access Journals (Sweden)

    Bendermacher Bianca LW


    Full Text Available Abstract Background Screening with ankle-brachial index (ABI measurement could be clinically relevant to avoid cardiovascular events in subjects with asymptomatic atherosclerosis. To assess the practical impact of guidelines regarding the use of ABI as a screening tool in general practice, the corresponding number needed to screen, including the required time investment, and the feasibility of ABI performance, was assessed. Methods An observational study was performed in the setting of 955 general practices in the Netherlands. Overall, 13,038 subjects of ≥55 years presenting with symptoms of intermittent claudication and/or presenting with ≥ one vascular risk factor were included. Several guidelines recommend the ABI as an additional measurement in selected populations for risk assessment for cardiovascular morbidity. Results Screening of the overall population of ≥50 years results in ≈862 subjects per general practice who should be screened, resulting in a time-requirement of approximately 6 weeks of full time work. Using an existing clinical prediction model, 247 patients per general practice should be screened for PAD by ABI measurement. Conclusion Screening the entire population of ≥50 years will in our opinion not be feasible in general practice. A more rationale and efficient approach might be screening of subsets of the population of ≥55 years based on a clinical prediction model.

  18. Mixed inhibitors of angiotensin-converting enzyme and enkephalinase: Rational design, properties, and potential cardiovascular applications of glycopril and alatriopril

    Energy Technology Data Exchange (ETDEWEB)

    Gros, C.; Noel, N.; Souque, A.; Schwartz, J.C. (Inst. National de la Sante et de la Recherche Medicale, Paris (France)); Danvy, D.; Plaquevent, J.C.; Duhamel, L.; Duhamel, P. (Univ. de Rouen, Mont Saint Aignan (France)); Lecomte, J.M. (Lab. Bioprojet, Paris (France)); Bralet, J. (Lab. de Pharmacodynamie, Dijon (France))


    Angiotensin-converting enzyme (ACE) and enkephalinase, two cell surface metallopeptidases, are responsible for angiotensin II formation and atrial natriuretic factor (ANF) degradation, respectively, and thereby play a critical role in the metabolism of hormonal peptides exerting essentially opposite actions in cardiovascular regulations. To affect simultaneously both hormonal systems by a single molecular structure, the authors designed glycoprilat and alatrioprilat {l brace}(S)-N-(3-(3,4-methylenedioxyphenyl)-2-(mercaptomethyl)-1-oxopropyl)glycine and -alanine, respectively{r brace}. In vitro the two compounds inhibit both ACE and enkephalinase activities with similar, nanomolar potencies, and in vivo, glycopril and alatriopril, the corresponding diester prodrugs, occupy the two enzyme molecules in lung at similar low dosages. The high potency of these compounds is attributable to interaction of the methylenedioxy group with the S{sub 1} subsite of ACE and of the aromatic ring with the S{prime}{sub 1} subsite of enkephalinase. In rodents, low doses of these mixed inhibitors exert typical actions of ACE inhibitors--i.e., prevention of angiotensin I-induced hypertension-as well as of enkephalinase inhibitors--i.e., protection from {sup 125}I-ANF degradation or enhancement of diuresis and natriuresis following acute extracellular volume expansion. In view of the known counterbalanced physiological actions of the two hormonal peptides, whose metabolism is controlled by ACE and enkephalinase, mixed inhibitors of the two peptidases show promise for the treatment of various cardiovascular and salt-retention disorders.

  19. Chemical looping combustion. Fuel conversion with inherent CO2 capture

    Energy Technology Data Exchange (ETDEWEB)

    Brandvoll, Oeyvind


    ONiAl do not rule out CLC as a viable alternative for CO2 capture, but long term durability studies along with realistic testing of the carrier in a continuous rig is needed to firmly conclude. For comparative purposes a perovskite was synthesized and tested in CLC, under similar conditions as NiONiAl. The results indicate that in a moving bed CLC application, perovskites have inherent disadvantages as compared to simpler compounds, by virtue of low relative oxygen content. (Author)

  20. Stereotypes, Students’ Perceptions and Inherent Creativity: Further Australian Evidence

    Directory of Open Access Journals (Sweden)

    Peter Baxter


    Full Text Available The objectives of this study are to: ascertain how first year university students perceive accounting in a timeperiod following the high profile corporate collapses of the early 21st century; understand the factors thatinfluence these perceptions; and determine if there is an association between students’ perceptions ofaccounting and their inherent creativity. The findings of the study show that the majority of first yearuniversity students still hold a traditional stereotypical perception of accounting. School teachers and subjectswere reported by the students as being the main influences on their perceptions. Students’ perceptions ofaccounting are also linked to their inherent creativity. A limitation of the study is that the sample is drawnfrom students at two Australian universities. Therefore, the results may not generalise to other institutions.This study contributes to the existing body of knowledge on students’ perceptions of accounting and theimpact of various factors. There are implications for educators in designing appropriate curricula and thepromotion of accounting by the accounting profession.

  1. Inherent Shear-Dilatation Coexistence in Metallic Glass

    Institute of Scientific and Technical Information of China (English)

    JIANG Min-Qiang; JIANG Si-Yue; DAI Lan-Hong


    Shear deformation can induce normal stress or hydrostatic stress in metallic glasses [Nature Mater. 2 (2003) 449, Intermetallics 14 (2006) 1033]. We perform the bulk deformation of three-dimensional Cu46Zr54 metallic glass (MG) and Cu single crystal model systems using molecular dynamics simulation. The results indicate that hydrostatic stress can incur shear stress in MG, but not in crystal. The resultant pronounced asymmetry between tension and compression originates from this inherent shear-dilatation coexistence in MG.

  2. Bioethanol production from germinated grain by inherent enzymes


    Kádár, Zsófia; Christensen, Anne Deen; Thomsen, Mette Hedegaard; Thomsen, Anne Belinda


    The malting in brewing process develops enzymes that are required to hydrolyze the complex starch in grain into simple fermentable sugars. These proceed the three following steps: Steeping encourages germination to start, germination prepares the conversion of the starch to sugars, and kilning stops the germination. In this study, a method for bioethanol production from rye grain was developed by utilizing the inherent amylase activity from germination of the seed. Grain germination was pe...

  3. Unusual inherent electrochemistry of graphene oxides prepared using permanganate oxidants. (United States)

    Eng, Alex Yong Sheng; Ambrosi, Adriano; Chua, Chun Kiang; Saněk, Filip; Sofer, Zdeněk; Pumera, Martin


    Graphene and graphene oxides are materials of significant interest in electrochemical devices such as supercapacitors, batteries, fuel cells, and sensors. Graphene oxides and reduced graphenes are typically prepared by oxidizing graphite in strong mineral acid mixtures with chlorate (Staudenmaier, Hofmann) or permanganate (Hummers, Tour) oxidants. Herein, we reveal that graphene oxides pose inherent electrochemistry, that is, they can be oxidized or reduced at relatively mild potentials (within the range ±1 V) that are lower than typical battery potentials. This inherent electrochemistry of graphene differs dramatically from that of the used oxidants. Graphene oxides prepared using chlorate exhibit chemically irreversible reductions, whereas graphene oxides prepared through permanganate-based methods exhibit very unusual inherent chemically reversible electrochemistry of oxygen-containing groups. Insight into the electrochemical behaviour was obtained through cyclic voltammetry, chronoamperometry, and X-ray photoelectron spectroscopy experiments. Our findings are of extreme importance for the electrochemistry community as they reveal that electrode materials undergo cyclic changes in charge/discharge cycles, which has strong implications for energy-storage and sensing devices.

  4. Earlier application of loading doses of aspirin and clopidogrel decreases rate of recurrent cardiovascular ischemic events for patients undergoing percutaneous coronary intervention

    Institute of Scientific and Technical Information of China (English)

    TANG Fa-kuan; LIN Le-jian; HUA Ning; LU Hong; QI Zhi; TANG Xue-zheng


    significantly increased compared with that in the control group,3%,10% and 1%,respectively (P <0.01).In contrast,the occurrence rates in the R+L group (10%,23% and 6%,respectively) were attenuated compared with those in the R+R group (P <0.01 ),although still higher than in the control group (P <0.01).Conclusions Almost all of the cardiovascular ischemic events occurred in the first six months after percutaneous coronary intervention.According to the result of TEG determinations,earlier application of a loading dose of aspirin and clopidogrel can decrease the rate of recurrent cardiovascular ischemic events.

  5. Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applications. (United States)

    Castellanos, Maria Isabel; Zenses, Anne-Sophie; Grau, Anna; Rodríguez-Cabello, Jose Carlos; Gil, Francisco Javier; Manero, Jose María; Pegueroles, Marta


    To improve cardiovascular implant success, metal-based stents are designated to modulate endothelial cells adhesion and migration in order to prevent restenosis and late thrombosis diseases. Biomimetic coatings with extra-cellular matrix adhesive biomolecules onto stents surfaces are a strategy to recover a healthy endothelium. However, the appropriate bioactive sequences to selective promote growth of endothelium and the biomolecules surface immobilization strategy remains to be elucidated. In this study, biofunctionalization of cobalt chromium, CoCr, alloy surfaces with elastin-like recombinamers, ELR, genetically modified with an REDV sequence, was performed to enhance metal surfaces endothelialization. Moreover, physical adsorption and covalent bonding were used as biomolecules binding strategies onto CoCr alloy. Surfaces were activated with plasma and etched with sodium hydroxide previous to silanization with 3-chloropropyltriethoxysilane and functionalized with the ELR. CoCr alloy surfaces were successfully biofunctionalized and the use of an ELR with an REDV sequence, allows conferring bioactivity to the biomaterials surface, demonstrating a higher cell adhesion and spreading of HUVEC cells on the different CoCr surfaces. This effect is emphasized as increases the amount of immobilized biomolecules and directly related to the immobilization technique, covalent bonding, and the increase of surface charge electronegativity. Our strategy of REDV elastin-like recombinamers immobilization onto CoCr alloy surfaces via covalent bonding through organosilanes provides a bioactive surface that promotes endothelial cell adhesion and spreading.

  6. Predicted changes in fatty acid intakes, plasma lipids, and cardiovascular disease risk following replacement of trans fatty acid-containing soybean oil with application-appropriate alternatives. (United States)

    Lefevre, Michael; Mensink, Ronald P; Kris-Etherton, Penny M; Petersen, Barbara; Smith, Kim; Flickinger, Brent D


    The varied functional requirements satisfied by trans fatty acid (TFA)--containing oils constrains the selection of alternative fats and oils for use as potential replacements in specific food applications. We aimed to model the effects of replacing TFA-containing partially hydrogenated soybean oil (PHSBO) with application-appropriate alternatives on population fatty acid intakes, plasma lipids, and cardiovascular disease (CVD) risk. Using the National Health and Nutrition Examination Survey 24-hour dietary recalls for 1999-2002, we selected 25 food categories, accounting for 86 % of soybean oil (SBO) and 79 % of TFA intake for replacement modeling. Before modeling, those in the middle quintile had a mean PHSBO TFA intake of 1.2 % of energy. PHSBO replacement in applications requiring thermal stability by either low-linolenic acid SBO or mid-oleic, low-linolenic acid SBO decreased TFA intake by 0.3 % of energy and predicted CVD risk by 0.7-0.8 %. PHSBO replacement in applications requiring functional properties with palm-based oils reduced TFA intake by 0.8 % of energy, increased palmitic acid intake by 1.0 % of energy, and reduced predicted CVD risk by 0.4 %, whereas replacement with fully hydrogenated interesterified SBO reduced TFA intake by 0.7 % of energy, increased stearic acid intake by 1.0 % of energy, and decreased predicted CVD risk by 1.2 %. PHSBO replacement in both thermal and functional applications reduced TFA intake by 1.0 % of energy and predicted CVD risk by 1.5 %. Based solely on changes in plasma lipids and lipoproteins, all PHSBO replacement models reduced estimated CVD risk, albeit less than previously reported using simpler replacement models.

  7. β-blockers in Reasonable Application and Limitations of Cardiovascular Disease%β受体阻滞剂在心血管疾病中的合理应用及局限性

    Institute of Scientific and Technical Information of China (English)



    目的探讨β受体阻滞剂在心血管疾病中的应用情况及其存在的局限性。方法对β受体阻滞剂的主要药物作用机制进行分析,并对该药剂在不同心血管疾病中的应用概况进行分析,总结在不同心血管类型疾病中的应用疗效,同时分析其存在的局限性。结果冠心病、高血压、心肌梗死以及其他的心血管疾病在使用β受体阻滞剂治疗后,病情都能够得到有效缓解。结论β受体阻滞剂在心血管疾病的应用过程中,能够很好的起到预防心血管疾病以及保护人体心血管功能的作用。%Objective Investigate Of β-blockers in cardiovascular disease and its existing limitations.Methods Analysis of the major mechanism of drug action on beta blockers,and the agent in the application of dif erent cardiovascular diseases Profiles analyzed,summary ef icacy in cardiovascular disease,analyzed its existence limitations. Results Coronary heart disease, hypertension, myocardial infarction and other cardiovascular diseases in the use of beta-blockers after treatment,the condition can be ef ectively al eviated.Conclusion β-blockers in cardiovascular disease process,to play the role of prevention of cardiovascular disease, as wel as the protection of human cardiovascular function.

  8. An Inherent Probabilistic Aspect of the Hough Transform

    Institute of Scientific and Technical Information of China (English)

    HU Zhanyi; YANG Changjiang; YANG Yi; MA Songde


    In this paper, a new property of the Hough transform is discovered, namely an inherent probabilistic aspect which is independent of the input image and embedded in the transformation process from the image space to the parameter space. It is shown that such a probabilistic aspect has a wide range of implications concerning the specification of implementation schemes and the performance of Hough transform. In particular, it is shown that in order to make the Hough transform really meaningful, anappropriate curve (surface) density function must be, either explicitlyor implicitly, supplied during its implementation process, and that the widely used approach to uniformly discretizing parameter space in the literature is generally inadequate.

  9. “Beauty is a Light in the Heart”1: The Transformative Potential of Optogenetics for Clinical Applications in Cardiovascular Medicine (United States)

    Boyle, Patrick M.; Karathanos, Thomas V.; Trayanova, Natalia A.


    Optogenetics is an exciting new technology in which viral gene or cell delivery is used to inscribe light sensitivity in excitable tissue to enable optical control of bioelectric behavior. Initial progress in the fledgling domain of cardiac optogenetics has included in vitro expression of various light-sensitive proteins in cell monolayers and transgenic animals to demonstrate an array of potentially useful applications, including light-based pacing, silencing of spontaneous activity, and spiral wave termination. In parallel to these developments, the cardiac modeling community has developed a versatile computational framework capable of realistically simulating optogenetics in biophysically detailed, patient-specific representations of the human heart, enabling the exploration of potential clinical applications in a predictive virtual platform. Towards the ultimate goal of assessing the feasibility and potential impact of optogenetics-based therapies in cardiovascular medicine, this review provides (1) a detailed synopsis of in vivo, in vitro, and in silico developments in the field and (2) a critical assessment of how existing clinical technology for gene/cell delivery and intra-cardiac illumination could be harnessed to achieve such lofty goals as light-based arrhythmia termination. PMID:25453984

  10. Basis, evidences and consequences of the inherent stellar encocooning

    CERN Document Server

    Celis, L


    Based on 7093 observations with photoelectrical photometrical measurements of 191 Mira stars, the following equations (from the papers [1] to [18]) give the basis to establish the Inherent Stellar Encocooning with the spectro-photometric characteristics of the red giant variable stars, especially the Miras, which have large amplitudes (approx 50% of giant variables). The specific basis that justifies a progressive covering with ionized molecules, cold gases, dust and grains are: The relation of the visual amplitudes A sub v =A sub r +E sub A whose real luminosity separate the intrinsic pulsation and amplitude excess effects due to the presence of molecules [145] and an opaque envelope of cool gases; The relation of the visual absolute magnitudes M sub v =M sub v sub r (P)+M sub a (delta sub T sub i sub O V) which is affected by an inherent absorption and/or occultation, and; The relation that defines the probable absolute luminosity and depends on the period and the (Sa) spectral type at maximum M sub v =-2.2...

  11. Application of infrared thermal imaging in the study of preventing cardiovascular and cerebrovascular diseases with Chinese medicine health food (United States)

    Li, Ziru; Zhang, Xusheng


    To explore the assessing technique which could objectively reflect the characteristics of Chinese medicine in the prevention of cardiovascular and cerebrovascular diseases, four balance features of infrared thermal images (ITI) corresponding to the up and down, left and right, proximal and distal balance of blood circulation of human body were studied. First, the ITI features of the middle-aged and elderly people with lipid abnormality history were compared with those of the healthy youth. It was found that the balance state of the youth was significantly better than that of the middle-aged and elderly, P<=0.01 for all the balance features. For the youth, the balance state of females was better than that of the males. But this sexual difference disappeared for the middle-aged and elderly group. Second, a double-blind randomized trial was carried out to study the influences of Shengyi capsule, a Chinese medicine health food with the function of helping to decrease serum lipid, on the balance features. The subjects were middle-aged and elderly people with lipid abnormality history. Shengyi capsule was taken by the trial group while Xuezhikang capsule (with lovastatin as the main effective component) by the control group for 108 days. The balance features of ITI showed that Shengyi was significantly better than Xuezhikang in improving the whole body balance of blood circulation (including the up and down, left and right, proximal and distal balance). The relative efficacy rate was 81.0% for the trial group and 33.3% for the control group, there was significant difference between the two groups (P=0.002). Shengyi could effectively decrease the low density lipoprotein cholesterol (LDL-C) but the effect of Xuezhikang in decreasing total cholesterol (TC) and LDL-C was better than Shengyi. Though the lipid-lowering effect of Shengyi was not as good as Xuezhikang, ITI reflected the obvious advantage of Shengyi in improving the whole body balance of blood circulation which

  12. Design studies on Cardiovascular & Intraoperative Brachytherapy and Multiphase Flow Metering. New applications of radiation in medicine and industry

    NARCIS (Netherlands)

    Clarijs, M.C.


    Since their discovery, now more than one hundred years ago, x-rays and radioactivity have been used in many applications: from medical care to process industry. We are now, however, more aware than ever of the harmful effects they can have on the human body. More sensitive detectors, better shieldin

  13. Cardiovascular Disease and Diabetes (United States)

    ... Disease Venous Thromboembolism Aortic Aneurysm More Cardiovascular Disease & Diabetes Updated:Nov 4,2016 The following statistics speak ... disease. This content was last reviewed August 2015. Diabetes • Home • About Diabetes • Why Diabetes Matters Introduction Cardiovascular ...

  14. Cardiovascular manifestations of phaeochromocytoma

    NARCIS (Netherlands)

    Prejbisz, A.; Lenders, J.W.M.; Eisenhofer, G.; Januszewicz, A.


    Clinical expression of phaeochromocytoma may involve numerous cardiovascular manifestations, but usually presents as sustained or paroxysmal hypertension associated with other signs and symptoms of catecholamine excess. Most of the life-threatening cardiovascular manifestations of phaeochromocytoma,

  15. Understanding cardiovascular disease (United States)

    ... page: // Understanding cardiovascular disease To use the sharing features on this page, ... lead to heart attack or stroke. Types of Cardiovascular Disease Coronary heart disease (CHD) is the most common ...

  16. APOE Genotyping, Cardiovascular Disease (United States)

    ... Home Visit Global Sites Search Help? APOE Genotyping, Cardiovascular Disease Share this page: Was this page helpful? Also ... of choice to decrease the risk of developing cardiovascular disease (CVD) . However, there is a wide variability in ...

  17. Chirality as an inherent general property of matter. (United States)

    Davankov, Vadim


    A statement has been formulated that chirality is an indispensable inherent property of all material objects, at one level of organization of matter or another. The translation of chirality from one level of material objects to another deserves our attention. The parity violation of weak interactions can be discussed in terms of the homochirality of the pool of fundamental particles, as it translates into optical activity of metal vapors. Individual photons and energy quanta are considered to be chiral entities, too, since they can be separated into beams of circularly polarized radiation. The chiral structure of the universe has been proposed and a method of determining the orientation of the axis of rotation of the universe suggested.

  18. Determination of the cadmium and copper content inherent to metallothionein

    Energy Technology Data Exchange (ETDEWEB)

    Raspor, B.; Kozar, S.; Pavicic, J.; Juric, D. [Ruder Boskovic Institute, Center for Marine Research Zagreb, P.O.B. 1016, HR-10 001 Zagreb (Croatia)


    The reliability of the voltammetric determination of the cadmium and copper content (at pH 1.0), inherent to metallothionein (MT) isolated from the digestive gland of Mytilus galloprovincialis, was investigated. An artifact signal enhancement of copper, caused by the cupric-thionein complex adsorption at the mercury electrode, was established. This artifact was removed by UV-digestion of the sample for 15-20 h prior to analysis. A similar artifact was not detected for cadmium, because at this pH the cadmium-thionein complex has dissociated, and cadmium exists in the ionic form. Therefore, the voltammetric analysis of the cadmium content can be performed directly at pH 1.0, without prior UV-digestion of the sample. (orig.) With 3 figs., 1 tab., 12 refs.

  19. Game Over Interdependent Networks: Rationality Makes the System Inherent Deficient

    CERN Document Server

    Fan, Yuhang; He, Shibo; Chen, Jiming; Sun, Youxian


    Many real-world systems are composed of interdependent networks that rely on one another. Such networks are typically designed and operated by different entities, who aim at maximizing their own interest. In this paper, we study the game over interdependent networks, investigating how the rational behaviors of entities impact the whole system. We first introduce a mathematical model to quantify the interacting payoffs among varying entities. Then we study the Nash equilibrium and compare it with the optimal social welfare. We reveal that the cooperation between different entities can be reached to maximize the social welfare only when the average degree of each network is constant. Otherwise, there may be a huge gap between the Nash equilibrium and optimal social welfare. Therefore, the rationality of different entities that operates these networks makes the system inherently deficient and even extremely vulnerable in some cases. Furthermore, we uncover some factors (such as weakening coupled strength of inte...

  20. Inherent variability in lead and copper collected during standardized sampling. (United States)

    Masters, Sheldon; Parks, Jeffrey; Atassi, Amrou; Edwards, Marc A


    Variability in the concentration of lead and copper sampled at consumers' taps poses challenges to assessing consumer health threats and the effectiveness of corrosion control. To examine the minimum variability that is practically achievable, standardized rigs with three lead and copper containing plumbing materials (leaded brass, copper tube with lead solder, and a lead copper connection) were deployed at five utilities and sampled with regimented protocols. Variability represented by relative standard deviation (RSD) in lead release was high in all cases. The brass had the lowest variability in lead release (RSD = 31 %) followed by copper-solder (RSD = 49%) and lead-copper (RSD = 80%). This high inherent variability is due to semi-random detachment of particulate lead to water, and represents a modern reality of water lead problems that should be explicitly acknowledged and considered in all aspects of exposure, public education, and monitoring.

  1. Deep seawater inherent optical properties in the Southern Ionian Sea

    CERN Document Server

    Riccobene, G; Ambriola, M; Ameli, F; Amore, I; Anghinolfi, M; Anzalone, A; Avanzini, C; Barbarino, G C; Barbarito, E; Battaglieri, M; Bellotti, R; Beverini, N; Bonori, M; Bouhadef, B; Brescia, M; Cacopardo, G; Cafagna, F; Capone, A; Caponetto, L; Castorina, E; Ceres, A; Chiarusi, T; Circella, M; Cocimano, R; Coniglione, R; Cordelli, M; Costa, M; Cuneo, S; D'Amico, A; De Bonis, G; De Marzo, C; De Rosa, G; De Vita, R; Distefano, C; Falchini, E; Fiorello, C; Flaminio, V; Fratini, K; Gabrielli, A; Galeotti, S; Gandolfi, E; Grimaldi, A; Habel, R; Leonora, E; Lo Presti, D; Lonardo, A; Longo, G; Lucarelli, F; Maccioni, E; Margiotta, A; Martini, A; Masullo, R; Megna, R; Migneco, E; Mongelli, M; Montaruli, T; Morganti, M; Musumeci, M; Nicolau, C A; Orlando, A; Osipenko, M; Osteria, G; Papaleo, R; Pappalardo, V; Petta, C; Piattelli, P; Raffaelli, F; Raia, G; Randazzo, N; Reito, S; Ricco, G; Ripani, M; Rovelli, A; Ruppi, M; Russo, G V; Russo, S; Sapienza, P; Schuller, J P; Sedita, M; Shirokov, E; Simeone, F; Sipala, V; Spurio, M; Taiuti, M; Terreni, G; Trasatti, L; Urso, S; Valente, V; Vicini, P


    The NEMO (NEutrino Mediterranean Observatory) Collaboration has been carrying out since 1998 an evaluation programme of deep sea sites suitable for the construction of the future Mediterranean km3 Cerenkov neutrino telescope. We investigated the seawater optical and oceanographic properties of several deep sea marine areas close to the Italian Coast. Inherent optical properties (light absorption and attenuation coefficients) have been measured as a function of depth using an experimental apparatus equipped with standard oceanographic probes and the commercial transmissometer AC9 manufactured by WETLabs. This paper reports on the visible light absorption and attenuation coefficients measured in deep seawater of a marine region located in the Southern Ionian Sea, 60-100 km SE of Capo Passero (Sicily). Data show that blue light absorption coefficient is about 0.015 1/m (corresponding to an absorption length of 67 m) close to the one of optically pure water and it doe not show seasonal variation.

  2. From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics:meeting report from the third international symposium on "New frontiers in cardiovascular research"


    Cabrera-Fuentes, Hector A.; Aragones, Julian; Bernhagen, Jürgen; Boening, Andreas; William A. Boisvert; Bøtker, Hans E.; Bulluck, Heerajnarain; Cook, Stuart; Di Lisa, Fabio; Engel, Felix B.; Engelmann, Bernd; Ferrazzi, Fulvia; Ferdinandy, Péter; Fong, Alan; Fleming, Ingrid


    In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematica...

  3. Cardiovascular comorbiditiy in psoriasis


    Gurcharan Singh; Simran Pal Singh Aneja


    The chronic inflammatory nature of psoriasis is also thought to predispose patients to other diseases with an inflammatory component, the most notable being cardiovascular and metabolic (cardiometabolite) disorders. This concept is supported by studies showing that psoriasis is associated with cardiovascular risk factors like diabetes, obesity, hypertension, dyslipidemia, smoking and diseases including MI. Given the increased prevalence of cardiovascular co morbidities in patients, dermatolog...

  4. Genome editing in cardiovascular diseases. (United States)

    Strong, Alanna; Musunuru, Kiran


    Genome-editing tools, which include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) systems, have emerged as an invaluable technology to achieve somatic and germline genomic manipulation in cells and model organisms for multiple applications, including the creation of knockout alleles, introducing desired mutations into genomic DNA, and inserting novel transgenes. Genome editing is being rapidly adopted into all fields of biomedical research, including the cardiovascular field, where it has facilitated a greater understanding of lipid metabolism, electrophysiology, cardiomyopathies, and other cardiovascular disorders, has helped to create a wider variety of cellular and animal models, and has opened the door to a new class of therapies. In this Review, we discuss the applications of genome-editing technology throughout cardiovascular disease research and the prospect of in vivo genome-editing therapies in the future. We also describe some of the existing limitations of genome-editing tools that will need to be addressed if cardiovascular genome editing is to achieve its full scientific and therapeutic potential.

  5. An unusual case of systemic cardiovascular side effects from the application of over-the-counter nasal decongestion drops


    Browning, Matthew G.; Seddon, James O; Yung, Lisa T M; Gough, Gemma


    A 78-year-old female with a history of stable angina, phoned for advice with chest pains following the application of 0.5% ephedrine nasal drops for nasal congestion, which she had bought over-the-counter on the recommendation of a pharmacist. On applying the medication, she developed chest pain which she recognised as her angina. The Foundation Year 2 general practitioner on duty consulted the British National Formulary (BNF), issue 56 and thought that nasal decongestant induced angina was u...

  6. The Wild Wild West: A Framework to Integrate mHealth Software Applications and Wearables to Support Physical Activity Assessment, Counseling and Interventions for Cardiovascular Disease Risk Reduction. (United States)

    Lobelo, Felipe; Kelli, Heval M; Tejedor, Sheri Chernetsky; Pratt, Michael; McConnell, Michael V; Martin, Seth S; Welk, Gregory J


    Physical activity (PA) interventions constitute a critical component of cardiovascular disease (CVD) risk reduction programs. Objective mobile health (mHealth) software applications (apps) and wearable activity monitors (WAMs) can advance both assessment and integration of PA counseling in clinical settings and support community-based PA interventions. The use of mHealth technology for CVD risk reduction is promising, but integration into routine clinical care and population health management has proven challenging. The increasing diversity of available technologies and the lack of a comprehensive guiding framework are key barriers for standardizing data collection and integration. This paper reviews the validity, utility and feasibility of implementing mHealth technology in clinical settings and proposes an organizational framework to support PA assessment, counseling and referrals to community resources for CVD risk reduction interventions. This integration framework can be adapted to different clinical population needs. It should also be refined as technologies and regulations advance under an evolving health care system landscape in the United States and globally.

  7. The Wild Wild West: A Framework to Integrate mHealth Software Applications and Wearables to Support Physical Activity Assessment, Counseling and Interventions for Cardiovascular Disease Risk Reduction (United States)

    Lobelo, Felipe; Kelli, Heval M.; Tejedor, Sheri Chernetsky; Pratt, Michael; McConnell, Michael V.; Martin, Seth S.; Welk, Gregory J.


    Physical activity (PA) interventions constitute a critical component of cardiovascular disease (CVD) risk reduction programs. Objective mobile health (mHealth) software applications (apps) and wearable activity monitors (WAMs) can advance both assessment and integration of PA counseling in clinical settings and support community-based PA interventions. The use of mHealth technology for CVD risk reduction is promising, but integration into routine clinical care and population health management has proven challenging. The increasing diversity of available technologies and the lack of a comprehensive guiding framework are key barriers for standardizing data collection and integration. This paper reviews the validity, utility and feasibility of implementing mHealth technology in clinical settings and proposes an organizational framework to support PA assessment, counseling and referrals to community resources for CVD risk reduction interventions. This integration framework can be adapted to different clinical population needs. It should also be refined as technologies and regulations advance under an evolving health care system landscape in the United States and globally. PMID:26923067

  8. Sugar-sweetened beverage intake and cardiovascular risk factor profile in youth with type 1 diabetes: application of measurement error methodology in the SEARCH Nutrition Ancillary Study. (United States)

    Liese, Angela D; Crandell, Jamie L; Tooze, Janet A; Kipnis, Victor; Bell, Ronny; Couch, Sarah C; Dabelea, Dana; Crume, Tessa L; Mayer-Davis, Elizabeth J


    The SEARCH Nutrition Ancillary Study aims to investigate the role of dietary intake on the development of long-term complications of type 1 diabetes in youth, and capitalise on measurement error (ME) adjustment methodology. Using the National Cancer Institute (NCI) method for episodically consumed foods, we evaluated the relationship between sugar-sweetened beverage (SSB) intake and cardiovascular risk factor profile, with the application of ME adjustment methodology. The calibration sample included 166 youth with two FFQ and three 24 h dietary recall data within 1 month. The full sample included 2286 youth with type 1 diabetes. SSB intake was significantly associated with higher TAG, total and LDL-cholesterol concentrations, after adjusting for energy, age, diabetes duration, race/ethnicity, sex and education. The estimated effect size was larger (model coefficients increased approximately 3-fold) after the application of the NCI method than without adjustment for ME. Compared with individuals consuming one serving of SSB every 2 weeks, those who consumed one serving of SSB every 2 d had 3.7 mg/dl (0.04 mmol/l) higher TAG concentrations and 4.0 mg/dl (0.10 mmol/l) higher total cholesterol and LDL-cholesterol concentrations, after adjusting for ME and covariates. SSB intake was not associated with measures of adiposity and blood pressure. Our findings suggest that SSB intake is significantly related to increased lipid levels in youth with type 1 diabetes, and that estimates of the effect size of SSB on lipid levels are severely attenuated in the presence of ME. Future studies in youth with diabetes should consider a design that will allow for the adjustment for ME when studying the influence of diet on health status.

  9. Communicating uncertainty: managing the inherent probabilistic character of hazard estimates (United States)

    Albarello, Dario


    Science is much more fixing the limits of our knowledge about possible occurrences than the identification of any "truth". This is particularly true when scientific statements concern prediction of natural phenomena largely exceeding the laboratory scale as in the case of seismogenesis. In these cases, many scenarios about future occurrences result possible (plausible) and the contribution of scientific knowledge (based on the available knowledge about underlying processes or the phenomenological studies) mainly consists in attributing to each scenario a different level of likelihood (probability). In other terms, scientific predictions in the field of geosciences (hazard assessment) are inherently probabilistic. However, despite of this, many scientist (seismologists, etc.) in communicating their position in public debates tend to stress the " truth" of their statements against the fancy character of pseudo-scientific assertions: stronger is the opposition of science and pseudo-science, more hidden becomes the probabilistic character of scientific statements. The problem arises when this kind of "probabilistic" knowledge becomes the basis of any political action (e.g., to impose expensive form of risk reducing activities): in these cases the lack of any definitive "truth" requires a direct assumption of responsibility by the relevant decider (being the single citizen or the legitimate expression of a larger community) to choose among several possibilities (however characterized by different levels of likelihood). In many cases, this can be uncomfortable and strong is the attitude to delegate to the scientific counterpart the responsibility of these decisions. This "transfer" from the genuine political field to an improper scientific context is also facilitated by the lack of a diffuse culture of "probability" outside the scientific community (and in many cases inside also). This is partially the effect of the generalized adoption (by media and scientific

  10. Cardiovascular disease: primary prevention, disease modulation and regenerative therapy.

    LENUS (Irish Health Repository)

    Sultan, Sherif


    Cardiovascular primary prevention and regeneration programs are the contemporary frontiers in functional metabolic vascular medicine. This novel science perspective harnesses our inherent ability to modulate the interface between specialized gene receptors and bioavailable nutrients in what is labeled as the nutrient-gene interaction. By mimicking a natural process through the conveyance of highly absorbable receptor specific nutrients, it is feasible to accelerate cell repair and optimize mitochondrial function, thereby achieving cardiovascular cure. We performed a comprehensive review of PubMed, EMBASE and Cochrane Review databases for articles relating to cardiovascular regenerative medicine, nutrigenomics and primary prevention, with the aim of harmonizing their roles within contemporary clinical practice. We searched in particular for large-scale randomized controlled trials on contemporary cardiovascular pharmacotherapies and their specific adverse effects on metabolic pathways which feature prominently in cardiovascular regenerative programs, such as nitric oxide and glucose metabolism. Scientific research on \\'cardiovascular-free\\' centenarians delineated that low sugar and low insulin are consistent findings. As we age, our insulin level increases. Those who can decelerate the rapidity of this process are prompting their cardiovascular rejuvenation. It is beginning to dawn on some clinicians that contemporary treatments are not only failing to impact on our most prevalent diseases, but they may be causing more damage than good. Primary prevention programs are crucial elements for a better outcome. Cardiovascular primary prevention and regeneration programs have enhanced clinical efficacy and quality of life and complement our conventional endovascular practice.

  11. Polymeric Endoaortic Paving (PEAP): Mechanical, Thermoforming, and Degradation Properties of Polycaprolactone/Polyurethane Blends for Cardiovascular Applications (United States)

    Ashton, John H.; Mertz, James A. M.; Harper, John L.; Slepian, Marvin J.; Mills, Joseph L.; McGrath, Dominic V.; Vande Geest, Jonathan P.


    Polymeric endoaortic paving (PEAP) is a process by which a polymer is endovascularly delivered and thermoformed to coat or “pave” the lumen of the aorta. This method may offer an improvement to conventional endoaortic therapy in allowing conformal graft application with reduced risk of endoleak and customization to complex patient geometries. Polycaprolactone (PCL)/polyurethane (PU) blends of various blend ratios were assessed as a potential material for PEAP by characterizing their mechanical, thermoforming, and degradation properties. Biaxial tension testing revealed that the blends' stiffness is similar to that of aortic tissue, is higher for blends with more PCL content, and may be affected by thermoforming and degradation. Tubes of blends were able to maintain a higher diameter increase after thermoforming at higher PCL content and higher heating temperatures; 50/50 blend tubes heated to 55°C were able to maintain 90% of the diameter increase applied. Delamination forces of the blends ranged from 41 to 235 N/m2. In a Pseudomonas lipase solution, the 50/50 blend had a 94% lower degradation rate than pure PCL, and the 10/90 blend exhibited no degradation. These results indicate that PEAP, consisting of a PCL/PU blend, may be useful in developing the next generation of endoaortic therapy. PMID:20832506

  12. Energy storage inherent in large tidal turbine farms. (United States)

    Vennell, Ross; Adcock, Thomas A A


    While wind farms have no inherent storage to supply power in calm conditions, this paper demonstrates that large tidal turbine farms in channels have short-term energy storage. This storage lies in the inertia of the oscillating flow and can be used to exceed the previously published upper limit for power production by currents in a tidal channel, while simultaneously maintaining stronger currents. Inertial storage exploits the ability of large farms to manipulate the phase of the oscillating currents by varying the farm's drag coefficient. This work shows that by optimizing how a large farm's drag coefficient varies during the tidal cycle it is possible to have some flexibility about when power is produced. This flexibility can be used in many ways, e.g. producing more power, or to better meet short predictable peaks in demand. This flexibility also allows trading total power production off against meeting peak demand, or mitigating the flow speed reduction owing to power extraction. The effectiveness of inertial storage is governed by the frictional time scale relative to either the duration of a half tidal cycle or the duration of a peak in power demand, thus has greater benefits in larger channels.

  13. Solving Optimal Control Problems by Exploiting Inherent Dynamical Systems Structures (United States)

    Flaßkamp, Kathrin; Ober-Blöbaum, Sina; Kobilarov, Marin


    Computing globally efficient solutions is a major challenge in optimal control of nonlinear dynamical systems. This work proposes a method combining local optimization and motion planning techniques based on exploiting inherent dynamical systems structures, such as symmetries and invariant manifolds. Prior to the optimal control, the dynamical system is analyzed for structural properties that can be used to compute pieces of trajectories that are stored in a motion planning library. In the context of mechanical systems, these motion planning candidates, termed primitives, are given by relative equilibria induced by symmetries and motions on stable or unstable manifolds of e.g. fixed points in the natural dynamics. The existence of controlled relative equilibria is studied through Lagrangian mechanics and symmetry reduction techniques. The proposed framework can be used to solve boundary value problems by performing a search in the space of sequences of motion primitives connected using optimized maneuvers. The optimal sequence can be used as an admissible initial guess for a post-optimization. The approach is illustrated by two numerical examples, the single and the double spherical pendula, which demonstrates its benefit compared to standard local optimization techniques.

  14. Airborne LIDAR as a tool for estimating inherent optical properties (United States)

    Trees, Charles; Arnone, Robert


    LIght Detection and Ranging (LIDAR) systems have been used most extensively to generate elevation maps of land, ice and coastal bathymetry. There has been space-, airborne- and land-based LIDAR systems. They have also been used in underwater communication. What have not been investigated are the capabilities of LIDARs to measure ocean temperature and optical properties vertically in the water column, individually or simultaneously. The practical use of bathymetric LIDAR as a tool for the estimation of inherent optical properties remains one of the most challenging problems in the field of optical oceanography. LIDARs can retrieve data as deep as 3-4 optical depths (e.g. optical properties can be measured through the thermocline for ~70% of the world's oceans). Similar to AUVs (gliders), UAV-based LIDAR systems will increase temporal and spatial measurements by several orders of magnitude. The LIDAR Observations of Optical and Physical Properties (LOOPP) Conference was held at NURC (2011) to review past, current and future LIDAR research efforts in retrieving water column optical/physical properties. This new observational platform/sensor system is ideally suited for ground truthing hyperspectral/geostationary satellite data in coastal regions and for model data assimilation.

  15. Inherently analog quantity representations in olive baboons (Papio anubis

    Directory of Open Access Journals (Sweden)

    Allison M Barnard


    Full Text Available Strong evidence indicates that non-human primates possess a numerical representation system, but the inherent nature of that system is still debated. Two cognitive mechanisms have been proposed to account for non-human primate numerical performance: (1 a discrete object-file system limited to quantities <4, and (2 an analog system which represents quantities comparatively but is limited by the ratio between two quantities. To test the underlying nature of non-human primate quantification, we asked eight experiment -naive olive baboons (Papio anubis to discriminate between number pairs containing small (<4, large (>4, or span (small vs. large numbers of food items presented simultaneously or sequentially. The prediction from the object-file hypothesis is that baboons will only accurately choose the larger quantity in small pairs, but not large or span pairs. Conversely, the analog system predicts that baboons will be successful with all numbers, and that success will be dependent on numerical ratio. We found that baboons successfully discriminated all pair types at above chance levels. In addition, performance significantly correlated with the ratio between the numerical values. Although performance was better for simultaneous trials than sequential trials, evidence favoring analog numerical representation emerged from both conditions, and was present even in the first exposure to number pairs. Together, these data favor the interpretation that a single, coherent analog representation system underlies spontaneous quantitative abilities in primates.

  16. Functionalised inherently conducting polymers as low biofouling materials. (United States)

    Zhang, Binbin; Nagle, Alex R; Wallace, Gordon G; Hanks, Timothy W; Molino, Paul J


    Diatoms are a major component of microbial biofouling layers that develop on man-made surfaces placed in aquatic environments, resulting in significant economic and environmental impacts. This paper describes surface functionalisation of the inherently conducting polymers (ICPs) polypyrrole (PPy) and polyaniline (PANI) with poly(ethylene glycol) (PEG) and their efficacy as fouling resistant materials. Their ability to resist interactions with the model protein bovine serum albumin (BSA) was tested using a quartz crystal microbalance with dissipation monitoring (QCM-D). The capacity of the ICP-PEG materials to prevent settlement and colonisation of the fouling diatom Amphora coffeaeformis (Cleve) was also assayed. Variations were demonstrated in the dopants used during ICP polymerisation, along with the PEG molecular weight, and the ICP-PEG reaction conditions, all playing a role in guiding the eventual fouling resistant properties of the materials. Optimised ICP-PEG materials resulted in a significant reduction in BSA adsorption, and > 98% reduction in diatom adhesion.

  17. Making appropriation 'stick': stabilizing politics in an 'inherently feminist' tool. (United States)

    Hasson, Katie Ann


    This article examines how feminist politics are made to 'stick' to appropriated technologies in the context of a contemporary feminist women's health clinic in the US. Feminist clinics such as 'FemHealth', founded as part of 1970s women's health movements, put medical tools and knowledge into lay women's hands, making the appropriation of medical technologies a centerpiece of their political project. In the process, they rejected the authority of physicians and gave new politicized meanings to the tools they claimed as their own. As lay healthworkers at FemHealth continued the project of appropriation, they also continued to negotiate their dependence on physicians to perform tasks that required a medical license. Drawing on participant observation and interviews with healthworkers, I argue that struggles over the role and authority of physicians in this clinic play out through debates over two similar and competing tools used in the abortion procedure: the single-tooth tenaculum and the cervical stabilizer. Many healthworkers invested in the stabilizer as 'inherently feminist' in hopes that it would maintain its politics even when passed into physicians' hands. While appropriation depends on the ability of users to alter a technology's meanings, actors may feel invested in the new politics taken on by appropriated tools and work towards making those meanings persist, or 'stick'.

  18. Dualheap Selection Algorithm: Efficient, Inherently Parallel and Somewhat Mysterious

    CERN Document Server

    Sepesi, Greg


    An inherently parallel algorithm is proposed that efficiently performs selection: finding the K-th largest member of a set of N members. Selection is a common component of many more complex algorithms and therefore is a widely studied problem. Not much is new in the proposed dualheap selection algorithm: the heap data structure is from J.W.J.Williams, the bottom-up heap construction is from R.W. Floyd, and the concept of a two heap data structure is from J.W.J. Williams and D.E. Knuth. The algorithm's novelty is limited to a few relatively minor implementation twists: 1) the two heaps are oriented with their roots at the partition values rather than at the minimum and maximum values, 2)the coding of one of the heaps (the heap of smaller values) employs negative indexing, and 3) the exchange phase of the algorithm is similar to a bottom-up heap construction, but navigates the heap with a post-order tree traversal. When run on a single processor, the dualheap selection algorithm's performance is competitive wit...

  19. Managing inherent complexity for sustainable walleye fisheries in Lake Erie (United States)

    Roseman, Edward F.; Drouin, Richard; Gaden, Marc; Knight, Roger; Tyson, Jeff; Zhao, Yingming; Taylor, William W.; Lynch, Abigail J.; Leonard, Nancy J.


    In Lake Erie, Walleye (Sander vitreus vitreus) is king. The naturally occurring species is the foundation of commercial fishing operations on the Canadian side of the lake and is a much-prized sport fish on the American side. Management of Lake Erie walleye fisheries is complex and takes place in an inter-jurisdictional setting composed of resource agencies from the states of Michigan (MDNR), Ohio (ODNR), Pennsylvania (PFBC), and New York (NYDEC) and the province of Ontario (OMNR). The complexity of walleye management is exacerbated by interactions among environmental and ecological changes in Lake Erie, complex life-history characteristics of the species, public demand for walleye, and cultural/governance differences among managing groups and their respective constituents. Success of future management strategies will largely hinge upon our ability to understand these inherent complexities and to employ tactics that successfully accommodate stock productivity and human demand in a highly dynamic environment. In this report, we review the history of Lake Erie walleye management, outline the multi-jurisdictional process for international management of walleye, and discuss strategies to address challenges facing managers.

  20. Soluble CD54 induces human endothelial cells ex vivo expansion useful for cardiovascular regeneration and tissue engineering application

    KAUST Repository

    Malara, N.M.


    Aim: Consistent expansion of primary human endothelial cells in vitro is critical in the development of engineered tissue. A variety of complex culture media and techniques developed from different basal media have been reported with alternate success. Incongruous results are further confounded by donor-to-donor variability and cellular source of derivation. Our results demonstrate how to overcome these limitations using soluble CD54 (sCD54) as additive to conventional culture medium. Methods and results: Isolated primary fragment of different vessel types was expanded in Ham\\'s F12 DMEM, enriched with growth factors, Fetal Calf Serum and conditioned medium of Human Umbilical Vein Endothelial Cells (HUVEC) collected at different passages. Cytokine content of culture media was analyzed in order to identify the soluble factors correlating with better proliferation profile. sCD54 was found to induce the in vitro expansion of human endothelial cells (HECs) independently from the vessels source and even in the absence of HUVEC-conditioned medium. The HECs cultivated in the presence of sCD54 (50 ng/ml), resulted positive for the expression of CD146 and negative for CD45, and lower fibroblast contamination. Cells were capable to proliferate with an S phase of 25%, to produce vascular endothelial growth factor, VEGF, (10 ng/ml) and to give origin to vessel-like tubule in vitro. Conclusion: Our results demonstrate that sCD54 is an essential factor for the in-vitro expansion of HECs without donor and vessel-source variability. Resulting primary cultures can be useful, for tissue engineering in regenerative medicine (e.g. artificial micro tissue generation, coating artificial heart valve etc.) and bio-nanotechnology applications. © 2015 The Authors. Published by Elsevier Ireland Ltd.

  1. Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular research. (United States)

    Sandhu, Jatinderpal K; Auluck, Janica; Ng, Leong L; Jones, Donald J L


    The accurate and specific measurement of vitamin D is increasingly important for determining the role of vitamin D in the pathogenesis of disease. Liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS) has increasingly become the analytical modality of choice for the analysis of vitamin D. There are many advantages to using LC/MS/MS, such as high specificity and sensitivity to help distinguish the isomers of vitamin D. This rapid method, modified from a Waters Corporation application note, consists of minimal sample manipulation using liquid-liquid extraction and incorporates an internal standard. The supernatant is dried down and injected onto an ultra-high-performance liquid chromatography/electrospray ionization tandem mass spectrometer. The total analysis time is 10 min per injection, enabling high throughput of samples. This method also incorporates two commercial quality control standards to provide a robust system with acceptable coefficient of variation. The analysis of control and heart failure plasma samples showed significant differences in the levels of vitamin D3 between these two groups; however, in the control group, there were individuals who were vitamin D deficient. Overall, the vitamin D3 levels were higher in control samples than in heart failure individuals. As expected, vitamin D2 levels were not observed in many of the samples analysed. This modified method is quick and incorporates an internal standard to allow for any loss in the extraction procedure. The method also includes quality control samples to enable assay standardization. The assay involves inexpensive pre-sample clean-up, aiding high throughput, which is important in many laboratories.

  2. Laser therapy in cardiovascular disease (United States)

    Rindge, David


    Cardiovascular disease is the number one cause of death worldwide. It is broadly defined to include anything which adversely affects the heart or blood vessels. One-third of Americans have one or more forms of it. By one estimate, average human life expectancy would increase by seven years if it were eliminated. The mainstream medical model seeks mostly to "manage" cardiovascular disease with pharmaceuticals or to surgically bypass or reopen blocked vessels via angioplasty. These methods have proven highly useful and saved countless lives. Yet drug therapy may be costly and ongoing, and it carries the risk of side effects while often doing little or nothing to improve underlying health concerns. Similarly, angioplasty or surgery are invasive methods which entail risk. Laser therapy1 regenerates tissue, stimulates biological function, reduces inflammation and alleviates pain. Its efficacy and safety have been increasingly well documented in cardiovascular disease of many kinds. In this article we will explore the effects of laser therapy in angina, atherosclerosis, coronary artery disease, hypertension, hyperlipidemia, myocardial infarction, stroke and other conditions. The clinical application of various methods of laser therapy, including laserpuncture and transcutaneous, supravascular and intravenous irradiation of blood will be discussed. Implementing laser therapy in the treatment of cardiovascular disease offers the possibility of increasing the health and wellbeing of patients while reducing the costs and enhancing safety of medical care.

  3. Cardiovascular magnetic resonance in systemic hypertension

    Directory of Open Access Journals (Sweden)

    Maceira Alicia M


    Full Text Available Abstract Systemic hypertension is a highly prevalent potentially modifiable cardiovascular risk factor. Imaging plays an important role in the diagnosis of underlying causes for hypertension, in assessing cardiovascular complications of hypertension, and in understanding the pathophysiology of the disease process. Cardiovascular magnetic resonance (CMR provides accurate and reproducible measures of ventricular volumes, mass, function and haemodynamics as well as uniquely allowing tissue characterization of diffuse and focal fibrosis. In addition, CMR is well suited for exclusion of common secondary causes for hypertension. We review the current and emerging clinical and research applications of CMR in hypertension.

  4. Defining the inherent stability of degenerative spondylolisthesis: a systematic review. (United States)

    Simmonds, Andrea M; Rampersaud, Y Raja; Dvorak, Marcel F; Dea, Nicolas; Melnyk, Angela D; Fisher, Charles G


    OBJECT A range of surgical options exists for the treatment of degenerative lumbar spondylolisthesis (DLS). The chosen technique inherently depends on the stability of the DLS. Despite a substantial body of literature dedicated to the outcome analysis of numerous DLS procedures, no consensus has been reached on defining or classifying the disorder with respect to stability or the role that instability should play in a treatment algorithm. The purpose of this study was to define grades of stability and to develop a guide for deciding on the optimal approach in surgically managing patients with DLS. METHODS The authors conducted a qualitative systematic review of clinical or biomechanical analyses evaluating the stability of and surgical outcomes for DLS for the period from 1990 to 2013. Research focused on nondegenerative forms of spondylolisthesis or spinal stenosis without associated DLS was excluded. The primary extracted results were clinical and radiographic parameters indicative of DLS instability. RESULTS The following preoperative parameters are predictors of stability in DLS: restabilization signs (disc height loss, osteophyte formation, vertebral endplate sclerosis, and ligament ossification), no disc angle change or less than 3 mm of translation on dynamic radiographs, and the absence of low-back pain. The validity and magnitude of each parameter's contribution can only be determined through appropriately powered prospective evaluation in the future. Identifying these parameters has allowed for the creation of a preliminary DLS instability classification (DSIC) scheme based on the preoperative assessment of DLS stability. CONCLUSIONS Spinal stability is an important factor to consider in the evaluation and treatment of patients with DLS. Qualitative assessment of the best available evidence revealed clinical and radiographic parameters for the creation of the DSIC, a decision aid to help surgeons develop a method of preoperative evaluation to better

  5. Cardiovascular Magnetic Resonance Imaging (United States)

    Pelc, Norbert


    Cardiovascular diseases are a major source of morbidity and mortality in the United States. Early detection of disease can often be used to improved outcomes, either through direct interventions (e.g. surgical corrections) or by causing the patient to modify his or her behavior (e.g. smoking cessation or dietary changes). Ideally, the detection process should be noninvasive (i.e. it should not be associated with significant risk). Magnetic Resonance Imaging (MRI) refers to the formation of images by localizing NMR signals, typically from protons in the body. As in other applications of NMR, a homogeneous static magnetic field ( ~0.5 to 4 T) is used to create ``longitudinal" magnetization. A magnetic field rotating at the Larmor frequency (proportional to the static field) excites spins, converting longitudinal magnetization to ``transverse" magnetization and generating a signal. Localization is performed using pulsed gradients in the static field. MRI can produce images of 2-D slices, 3-D volumes, time-resolved images of pseudo-periodic phenomena such as heart function, and even real-time imaging. It is also possible to acquire spatially localized NMR spectra. MRI has a number of advantages, but perhaps the most fundamental is the richness of the contrast mechanisms. Tissues can be differentiated by differences in proton density, NMR properties, and even flow or motion. We also have the ability to introduce substances that alter NMR signals. These contrast agents can be used to enhance vascular structures and measure perfusion. Cardiovascular MRI allows the reliable diagnosis of important conditions. It is possible to image the blood vessel tree, quantitate flow and perfusion, and image cardiac contraction. Fundamentally, the power of MRI as a diagnostic tool stems from the richness of the contrast mechanisms and the flexibility in control of imaging parameters.

  6. Distribution of Inherent Strains and Residual Stresses in Medium Thickness Plate Weldment

    Institute of Scientific and Technical Information of China (English)


    A fundamental theory for the analysis of residual weldingstresses and deformation based on the inherent strain distribution along the welded joint is introduced. Distribution of inherent strains and longitudinal residual stresses in medium thickness plate weldment is calculated and analyzed.A new method of calculating inherent strains and longitudinal residual stresses is proposed.

  7. Registration of optical imagery and LiDAR data using an inherent geometrical constraint. (United States)

    Zhang, Wuming; Zhao, Jing; Chen, Mei; Chen, Yiming; Yan, Kai; Li, Linyuan; Qi, Jianbo; Wang, Xiaoyan; Luo, Jinghui; Chu, Qing


    A novel method for registering imagery with Light Detection And Ranging (LiDAR) data is proposed. It is based on the phenomenon that the back-projection of LiDAR point cloud of an object should be located within the object boundary in the image. Using this inherent geometrical constraint, the registration parameters computation of both data sets only requires LiDAR point clouds of several objects and their corresponding boundaries in the image. The proposed registration method comprises of four steps: point clouds extraction, boundary extraction, back-projection computation and registration parameters computation. There are not any limitations on the geometrical and spectral properties of the object. So it is suitable not only for structured scenes with man-made objects but also for natural scenes. Moreover, the proposed method based on the inherent geometrical constraint can register two data sets derived from different parts of an object. It can be used to co-register TLS (Terrestrial Laser Scanning) LiDAR point cloud and UAV (Unmanned aerial vehicle) image, which are obtaining more attention in the forest survey application. Using initial registration parameters comparable to POS (position and orientation system) accuracy, the performed experiments validated the feasibility of the proposed registration method.

  8. Effective material parameter retrieval of anisotropic elastic metamaterials with inherent nonlocality (United States)

    Lee, Hyung Jin; Lee, Heung Son; Ma, Pyung Sik; Kim, Yoon Young


    In this paper, the scattering (S-) parameter retrieval method is presented specifically for anisotropic elastic metamaterials; so far, no retrieval has been accomplished when elastic metamaterials exhibit fully anisotropic behavior. Complex constitutive property and intrinsic scattering behavior of elastic metamaterials make their characterization far more complicated than that for acoustic and electromagnetic metamaterials. In particular, elastic metamaterials generally exhibit anisotropic scattering behavior due to higher scattering modes associated with shear deformation. They also exhibit nonlocal responses to some degrees, which originate from strong multiple scattering interactions even in the long wavelength limit. Accordingly, the conventional S-parameter retrieval methods cannot be directly used for elastic metamaterials, because they determine only the diagonal components in effective tensor property. Also, the conventional methods simply use the analytic inversion formulae for the material characterization so that inherent nonlocality cannot be taken into account. To establish a retrieval method applicable to anisotropic elastic metamaterials, we propose an alternative S-parameter method to deal with full anisotropy of elastic metamaterials. To retrieve the whole effective anisotropic parameter, we utilize not only normal but also oblique wave incidences. For the retrieval, we first retrieve the ratio of the effective stiffness tensor to effective density and then determine the effective density. The proposed retrieval method is validated by characterizing the effective material parameters of various types of non-resonant anisotropic metamaterials. It is found that the whole effective parameters are retrieved consistently regardless of used retrieval conditions in spite of inherent nonlocality.

  9. Improved Cardiovascular Disease Outcomes in Older Adults [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Daniel E. Forman


    Full Text Available Longevity is increasing and the population of older adults is growing. The biology of aging is conducive to cardiovascular disease (CVD, such that prevalence of coronary artery disease, heart failure, valvular heart disease, arrhythmia and other disorders are increasing as more adults survive into old age.  Furthermore, CVD in older adults is distinctive, with management issues predictably complicated by multimorbidity, polypharmacy, frailty and other complexities of care that increase management risks (e.g., bleeding, falls, and rehospitalization and uncertainty of outcomes.  In this review, state-of-the-art advances in heart failure, acute coronary syndromes, transcatheter aortic valve replacement, atrial fibrillation, amyloidosis, and CVD prevention are discussed.  Conceptual benefits of treatments are considered in relation to the challenges and ambiguities inherent in their application to older patients.

  10. Mitigation of Severe Accident Consequences Using Inherent Safety Principles

    Energy Technology Data Exchange (ETDEWEB)

    R. A. Wigeland; J. E. Cahalan


    Sodium-cooled fast reactors are designed to have a high level of safety. Events of high probability of occurrence are typically handled without consequence through reliable engineering systems and good design practices. For accidents of lower probability, the initiating events are characterized by larger and more numerous challenges to the reactor system, such as failure of one or more major engineered systems and can also include a failure to scram the reactor in response. As the initiating conditions become more severe, they have the potential for creating serious consequences of potential safety significance, including fuel melting, fuel pin disruption and recriticality. If the progression of such accidents is not mitigated by design features of the reactor, energetic events and dispersal of radioactive materials may result. For severe accidents, there are several approaches that can be used to mitigate the consequences of such severe accident initiators, which typically include fuel pin failures and core disruption. One approach is to increase the reliability of the reactor protection system so that the probability of an ATWS event is reduced to less than 1 x 10-6 per reactor year, where larger accident consequences are allowed, meeting the U.S. NRC goal of relegating such accident consequences as core disruption to these extremely low probabilities. The main difficulty with this approach is to convincingly test and guarantee such increased reliability. Another approach is to increase the redundancy of the reactor scram system, which can also reduce the probability of an ATWS event to a frequency of less than 1 x 10-6 per reactor year or lower. The issues with this approach are more related to reactor core design, with the need for a greater number of control rod positions in the reactor core and the associated increase in complexity of the reactor protection system. A third approach is to use the inherent reactivity feedback that occurs in a fast reactor to

  11. Pharmacological Effects of Organic Acids in Chinese Herbs and its Application in Cardiovascular Diseases%中药有机酸类成分的药理作用及在心血管疾病的应用

    Institute of Scientific and Technical Information of China (English)

    汤喜兰; 刘建勋; 李磊


    To review the research about the pharmacological effects of organic acids in chinese herbs and its application in cardiovascular diseases. To summarize and analyze related literature about the pharmacological effects of organic acids in chinese herbs and its application in cardiovascular diseases in recent years in China and abroad. Organic Acids in Chinese Herbs has a wide range of pharmacological effects, such as anti-inflammatory response, anti-platelet aggregation, antioxidant and inducing tumor cell apoptosis and so on. The effects of anti-inflammatory response, anti-platelet aggregation and antioxidant may have potential clinical application value for cardiovascular system diseases. We should attach importance to organic acids in chinese herbs and its application in cardiovascular diseases. It is important to clarify the material basis for efficacy of Chinese drugs and provide a new method for preventing and treatment of cardiovascular diseases.%对中药有机酸类成分的药理作用及在心血管疾病的应用进行综述.查阅国内外相关文献并对其进行分析.中药有机酸类成分药理作用广泛,如抗炎症反应,抑制血小板聚集、抗血栓,抗氧化,诱导肿瘤细胞凋亡等,其中抗炎症反应,抑制血小板聚集、抗血栓,抗氧化的药理作用可能对心血管系统疾病具有潜在的临床应用价值.重视中药有机酸类成分在心血管系统疾病中的科学研究,对于中药作用药效物质基础的阐明有重要意义,同时也为心血管疾病的防治提供了新的思路.

  12. Lifestyle in Cardiovascular Disease

    NARCIS (Netherlands)

    J.O. Younge (John)


    markdownabstract__Abstract__ Globally, the burden of cardiovascular disease (CVD) is still increasing. However, in recent decades, better treatment modalities have led to less cardiovascular related deaths. After years of research, we now generally accept that lifestyle factors are the most importa

  13. Triglycerides and cardiovascular disease

    DEFF Research Database (Denmark)

    Nordestgaard, Børge G; Varbo, Anette


    cholesterol might not cause cardiovascular disease as originally thought has now generated renewed interest in raised concentrations of triglycerides. This renewed interest has also been driven by epidemiological and genetic evidence supporting raised triglycerides, remnant cholesterol, or triglyceride......-rich lipoproteins as an additional cause of cardiovascular disease and all-cause mortality. Triglycerides can be measured in the non-fasting or fasting states, with concentrations of 2-10 mmol/L conferring increased risk of cardiovascular disease, and concentrations greater than 10 mmol/L conferring increased risk...... of acute pancreatitis and possibly cardiovascular disease. Although randomised trials showing cardiovascular benefit of triglyceride reduction are scarce, new triglyceride-lowering drugs are being developed, and large-scale trials have been initiated that will hopefully provide conclusive evidence...

  14. 76 FR 39404 - Cardiovascular and Renal Drugs Advisory Committee; Notice of Meeting (United States)


    ... HUMAN SERVICES Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee; Notice of... to the public. Name of Committee: Cardiovascular and Renal Drugs Advisory Committee. General Function... application (NDA) 202439, rivaroxaban tablets, submitted by Johnson & Johnson Pharmaceutical Research...

  15. Robotic technology in cardiovascular medicine. (United States)

    Bonatti, Johannes; Vetrovec, George; Riga, Celia; Wazni, Oussama; Stadler, Petr


    Robotic technology has been used in cardiovascular medicine since the late 1990s. Interventional cardiology, electrophysiology, endovascular surgery, minimally invasive cardiac surgery, and laparoscopic vascular surgery are all fields of application. Robotic devices enable endoscopic reconstructive surgery in narrow spaces and fast, very precise placement of catheters and devices in catheter-based interventions. In all robotic systems, the operator manipulates the robotic arms from a control station or console. In the field of cardiac surgery, mitral valve repair, CABG surgery, atrial septal defect repair, and myxoma resection can be achieved using robotic technology. Furthermore, vascular surgeons can perform a variety of robotically assisted operations to treat aortic, visceral, and peripheral artery disease. In electrophysiology, ablation procedures for atrial fibrillation can be carried out with robotic support. In the past few years, robotically assisted percutaneous coronary intervention and abdominal aortic endovascular surgery techniques have been developed. The basic feasibility and safety of robotic approaches in cardiovascular medicine has been demonstrated, but learning curves and the high costs associated with this technology have limited its widespread use. Nonetheless, increased procedural speed, accuracy, and reduced exposure to radiation and contrast agent in robotically assisted catheter-based interventions, as well as reduced surgical trauma and shortened patient recovery times after robotic cardiovascular surgery are promising achievements in the field.

  16. Cardiovascular comorbiditiy in psoriasis

    Directory of Open Access Journals (Sweden)

    Gurcharan Singh


    Full Text Available The chronic inflammatory nature of psoriasis is also thought to predispose patients to other diseases with an inflammatory component, the most notable being cardiovascular and metabolic (cardiometabolite disorders. This concept is supported by studies showing that psoriasis is associated with cardiovascular risk factors like diabetes, obesity, hypertension, dyslipidemia, smoking and diseases including MI. Given the increased prevalence of cardiovascular co morbidities in patients, dermatologists treating psoriasis need to approach the disease as a potentially multisystem disorder and must alert these patients to the potentially negative effects of their disease.

  17. Urocortin and cardiovascular protection

    Institute of Scientific and Technical Information of China (English)

    Yu HUANG; Xiao-qiang YAO; Chi-wai LAU; Yau-chi CHAN; Suk-ying TSANG; Franky Leung CHAN


    Urocortin and other hypothalamus corticotropin-releasing factor (CRF) polypeptides play biologically diverse roles in the stress, cardiovascular and inflammatory responses by acting on central and peripheral CRF receptors.Urocortin shows a significantly high sequence homology to CRF, and the concurrent expression of type-2 CRF (CRF2) receptors with urocortin in the heart suggests that urocortin may play a physiological role in the cardiac function. Urocortin is thought to be the endogenous agonist producing the cardiovascular actions previously attributed to CRF. This review highlights the current novel findings on the molecular and cellular mechanisms by which urocortin may exert its cardiovascular protective action.

  18. Modified diagnosis of cardiovascular diseases: Application and comparison of diagnostic techniques in clinical medicine, radiology, ultrasonography and nuclear medicine. Final report. Einsatz und Vergleich klinischer, roentgenologischer, sonographischer und nuklearmedizinischer Methoden zur abgestuften Diagnostik von Herzkrankheiten. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Adam, W.; Boettcher, D.; Christl, H.; Baew-Christow, T.; Holper, H.; Meindl, S.; Meyer, U.; Pfannenstiel, P.


    The main point of interest of the project is the question whether ultrasonography, myocardial scintiscanning, and radionuclide angiocardiography can replace the invasive techniques of cardiovascular diagnosis, and thus save costs at that. The results show that the above non-invasive techniques are indispensable in case of a diagnosis for cardiosurgery, almost sufficient in case of valvular heart disease, and sufficient in all cases of cardiomyopathy. Optimally planned application of the non-invasive methods could save about DM 7.3 millions a year in the FRG. (TRV).

  19. Simultaneous, inherently temperature and strain insensitive bio-sensors based on dual-resonance long-period gratings

    CERN Document Server

    Tripathi, Saurabh Mani; Bock, Wojtek J; Mikulic, Predrag


    Addressing the temperature and strain induced cross-talks simultaneously, we propose an inherently strain and temperature insensitive fiber-optic bio-sensor. The insensitivity has been achieved by properly adjusting the dopants and their concentrations in the optical fiber core region, and by optimizing the grating period and the strength of concatenated dual-resonance long-period-gratings. The simulations have been carried out using the same fiber parameters as used in our earlier experimental studies, which matched excellently with the experimental results. The proposed sensor has a theoretical refractive-index sensitivity of 4607 nm/RIU, which can be used to detect changes as small as 2.2 x10^-7 in ambient refractive indices using a detection system with spectral resolution of 1 pm. Our work finds application in developing precision biosensors with inherent insensitivity towards temperature and axial strain fluctuations. The sensor is currently under fabrication at our lab.

  20. Cardiovascular manifestations in hyperthyroidism

    Directory of Open Access Journals (Sweden)

    Vairamani Kandan


    Conclusions: This study shows that cardiovascular manifestations are quite common and varied in hyperthyroidism which are to be looked for in the management. [Int J Res Med Sci 2016; 4(7.000: 3032-3038

  1. A computational model of cardiovascular physiology and heart sound generation. (United States)

    Watrous, Raymond L


    A computational model of the cardiovascular system is described which provides a framework for implementing and testing quantitative physiological models of heart sound generation. The lumped-parameter cardiovascular model can be solved for the hemodynamic variables on which the heart sound generation process is built. Parameters of the cardiovascular model can be adjusted to represent various normal and pathological conditions, and the acoustic consequences of those adjustments can be explored. The combined model of the physiology of cardiovascular circulation and heart sound generation has promise for application in teaching, training and algorithm development in computer-aided auscultation of the heart.

  2. [Vitamin D and cardiovascular risk]. (United States)

    Mayer, Otto


    The pathogenesis of cardiovascular disease is without any doubt multifactorial, and it is generally accepted, that conventional risk factors determined only about 80% of cardiovascular risk. There is accumulating evidence that vitamin D exerts important pathophysiological effects on cardiovascular system. Low vitamin D was associated with increased cardiovascular risk in several reports. This review summarizes recent epidemiological evidence and possible pathophysiological mechanism for a role of low vitamin D in cardiovascular diseases. Moreover, available data concerning vitamin D supplementation are depicted.

  3. ADMA, cardiovascular disease and diabetes. (United States)

    Krzyzanowska, Katarzyna; Mittermayer, Friedrich; Wolzt, Michael; Schernthaner, Guntram


    The endogenous competitive nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) is an emerging risk marker for future cardiovascular events. Elevated ADMA concentrations have been described in patients with an adverse cardiovascular risk profile. Recently, various studies investigated the independent role of ADMA as a cardiovascular risk predictor in several patient cohorts. In addition, ADMA might not only be a risk marker but also a causative factor for cardiovascular disease. This review summarizes the literature on the relationship between ADMA, cardiovascular disease and diabetes.

  4. Facile optimal synthesis of inherently electroconductive polythiophene nanoparticles. (United States)

    Li, Xin-Gui; Li, Ji; Huang, Mei-Rong


    demonstrate uncommon characteristics including easy synthesis, low cost of production, large pi-conjugated structure, high conductivity, solution processability, and extensive potential for further application.

  5. Structural interpretation of seismic data and inherent uncertainties (United States)

    Bond, Clare


    Geoscience is perhaps unique in its reliance on incomplete datasets and building knowledge from their interpretation. This interpretation basis for the science is fundamental at all levels; from creation of a geological map to interpretation of remotely sensed data. To teach and understand better the uncertainties in dealing with incomplete data we need to understand the strategies individual practitioners deploy that make them effective interpreters. The nature of interpretation is such that the interpreter needs to use their cognitive ability in the analysis of the data to propose a sensible solution in their final output that is both consistent not only with the original data but also with other knowledge and understanding. In a series of experiments Bond et al. (2007, 2008, 2011, 2012) investigated the strategies and pitfalls of expert and non-expert interpretation of seismic images. These studies focused on large numbers of participants to provide a statistically sound basis for analysis of the results. The outcome of these experiments showed that a wide variety of conceptual models were applied to single seismic datasets. Highlighting not only spatial variations in fault placements, but whether interpreters thought they existed at all, or had the same sense of movement. Further, statistical analysis suggests that the strategies an interpreter employs are more important than expert knowledge per se in developing successful interpretations. Experts are successful because of their application of these techniques. In a new set of experiments a small number of experts are focused on to determine how they use their cognitive and reasoning skills, in the interpretation of 2D seismic profiles. Live video and practitioner commentary were used to track the evolving interpretation and to gain insight on their decision processes. The outputs of the study allow us to create an educational resource of expert interpretation through online video footage and commentary with

  6. Prediction Models on Distribution of Inherent Strains in T Type Welding Structure

    Institute of Scientific and Technical Information of China (English)

    Peng HE; Jicai FENG; Jiecai HAN; Yiyu QIAN


    A fundamental theory for the analysis of residual welding stresses and deformation based on the inherent strain distribution along the welded joint is introduced. The method of predicting maximum hardness Hv(y, z) and maximum inherent strain gmax is given

  7. Concept of an inherently-safe high temperature gas-cooled reactor

    Energy Technology Data Exchange (ETDEWEB)

    Ohashi, Hirofumi; Sato, Hiroyuki; Tachibana, Yukio; Kunitomi, Kazuhiko; Ogawa, Masuro [Nuclear Hydrogen and Heat Application Research Center, Japan Atomic Energy Agency, Oarai-machi, Ibaraki-ken, 311-1394 (Japan)


    As the challenge to ensure no harmful release of radioactive materials at the accidents by deterministic approach instead to satisfy acceptance criteria or safety goal for risk by probabilistic approach, new concept of advanced reactor, an inherently-safe high temperature gas-cooled reactor, is proposed based on the experience of the operation of the actual High Temperature Gas-cooled Reactor (HTGR) in Japan, High Temperature Engineering Test Reactor (HTTR), and the design of the commercial plant (GTHTR300), utilizing the inherent safety features of the HTGR (i.e., safety features based on physical phenomena). The safety design philosophy of the inherently-safe HTGR for the safety analysis of the radiological consequences is determined as the confinement of radioactive materials is assured by only inherent safety features without engineered safety features, AC power or prompt actions by plant personnel if the design extension conditions occur. Inherent safety features to prevent the loss or degradation of the confinement function are identified. It is proposed not to apply the probabilistic approach for the evaluation of the radiological consequences of the accidents in the safety analysis because no inherent safety features fail for the mitigation of the consequences of the accidents. Consequently, there are no event sequences to harmful release of radioactive materials if the design extension conditions occur in the inherently-safe HTGR concept. The concept and future R and D items for the inherently-safe HTGR are described in this paper.

  8. Strategische keuzen in verkeersveiligheidsbeleid en onderzoek : naar een inherent veiliger wegverkeer.

    NARCIS (Netherlands)

    Roszbach, R.


    In the Multiyear plan for traffic safety the terms "inherent safe" and "systematic management" were used. This report explains why these terms can be used and shows their correlation in the traffic safety theories. Some elements which can be a part of an inherent safe traffic and transport system ar

  9. Are the current recommendations for the use of aspirin in primary prevention of cardiovascular disease applicable in low-income countries?

    Directory of Open Access Journals (Sweden)

    Noubiap JJ


    Full Text Available Jean Jacques N Noubiap,1,2 Jobert Richie N Nansseu3,41Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; 2Medical Diagnostic Center, Yaoundé, Cameroon; 3Sickle Cell Disease Unit, Mother and Child Centre, Chantal BIYA Foundation, Yaoundé, Cameroon; 4Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, CameroonAbstract: Although evidence has accumulated that long-term aspirin therapy is beneficial in secondary prevention of cardiovascular disease (CVD, a lot of controversies persist regarding the benefit of aspirin use in primary prevention of CVD. In low-income countries (LIC specifically, the decision to prescribe aspirin for primary CVD prevention is more problematic, as there is a dearth of evidence in this regard. Aspirin has been shown to have relative beneficial effects in preventing a first myocardial infarction, but not stroke. However, as stroke is the prevailing CVD in many LIC, especially in Africa, the benefit of aspirin in these settings is therefore questionable. Indeed, there is no published trial that has evaluated the benefits and risks of continuous aspirin therapy in populations of LIC. Furthermore, though cardiovascular risk assessment is crucial in decision-making for the use of aspirin in primary prevention of CVD, there are no risk assessment tools that have been validated in African populations. Studies are urgently warranted, to determine the usefulness of aspirin in primary prevention of CVD in low-income settings where the drug is highly available and affordable, as CVD is becoming the leading cause of deaths in LIC.Keywords: aspirin, cardiovascular disease, primary prevention, low-income countries

  10. Multifaceted prospects of nanocomposites for cardiovascular grafts and stents. (United States)

    Vellayappan, Muthu Vignesh; Balaji, Arunpandian; Subramanian, Aruna Priyadarshini; John, Agnes Aruna; Jaganathan, Saravana Kumar; Murugesan, Selvakumar; Supriyanto, Eko; Yusof, Mustafa


    Cardiovascular disease is the leading cause of death across the globe. The use of synthetic materials is indispensable in the treatment of cardiovascular disease. Major drawbacks related to the use of biomaterials are their mechanical properties and biocompatibility, and these have to be circumvented before promoting the material to the market or clinical setting. Revolutionary advancements in nanotechnology have introduced a novel class of materials called nanocomposites which have superior properties for biomedical applications. Recently, there has been a widespread recognition of the nanocomposites utilizing polyhedral oligomeric silsesquioxane, bacterial cellulose, silk fibroin, iron oxide magnetic nanoparticles, and carbon nanotubes in cardiovascular grafts and stents. The unique characteristics of these nanocomposites have led to the development of a wide range of nanostructured copolymers with appreciably enhanced properties, such as improved mechanical, chemical, and physical characteristics suitable for cardiovascular implants. The incorporation of advanced nanocomposite materials in cardiovascular grafts and stents improves hemocompatibility, enhances antithrombogenicity, improves mechanical and surface properties, and decreases the microbial response to the cardiovascular implants. A thorough attempt is made to summarize the various applications of nanocomposites for cardiovascular graft and stent applications. This review will highlight the recent advances in nanocomposites and also address the need of future research in promoting nanocomposites as plausible candidates in a campaign against cardiovascular disease.

  11. Diabetes Drugs and Cardiovascular Safety

    Directory of Open Access Journals (Sweden)

    Ji Cheol Bae


    Full Text Available Diabetes is a well-known risk factor of cardiovascular morbidity and mortality, and the beneficial effect of improved glycemic control on cardiovascular complications has been well established. However, the rosiglitazone experience aroused awareness of potential cardiovascular risk associated with diabetes drugs and prompted the U.S. Food and Drug Administration to issue new guidelines about cardiovascular risk. Through postmarketing cardiovascular safety trials, some drugs demonstrated cardiovascular benefits, while some antidiabetic drugs raised concern about a possible increased cardiovascular risk associated with drug use. With the development of new classes of drugs, treatment options became wider and the complexity of glycemic management in type 2 diabetes has increased. When choosing the appropriate treatment strategy for patients with type 2 diabetes at high cardiovascular risk, not only the glucose-lowering effects, but also overall benefits and risks for cardiovascular disease should be taken into consideration.

  12. Efficacy of Female Rat Models in Translational Cardiovascular Aging Research

    Directory of Open Access Journals (Sweden)

    K. M. Rice


    Full Text Available Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in primates and rodents; however it is unknown how well the effects of aging in rat models translate into humans. To compound the complication of aging gender has also been indicated as a risk factor for various cardiovascular diseases. This review addresses the systemic pathophysiology of the cardiovascular system associated with aging and gender for aging research with regard to the applicability of rat derived data for translational application to human aging.

  13. Technological competencies in cardiovascular nursing education

    Directory of Open Access Journals (Sweden)

    Rika Miyahara Kobayashi


    Full Text Available Abstract OBJECTIVE To identify the perception of the coordinators of the Specialization Courses in Cardiovascular Nursing about inserting content from Information and Communication Technology (ICT and analyze them in relation to the technological competencies and regarding its applicability, relevance and importance in assisting, teaching and management. METHOD Descriptive study with 10 coordinators of the Specialization course in Cardiologic Nursing, who replied to the questionnaire for the development of technological competency adapted from the Technology Initiative Guidelines Education Reforms (TIGER, and analyzed using the Delphi technique for obtaining consensus and scored according to the relevance, pertinence and applicability using Likert scale according to degree of agreement. RESULTS Six courses developed ICT content. The contents of the TIGER were considered relevant, pertinent and applicable. CONCLUSION The coordinators recognize the need for technological competencies of the Cardiovascular Nurse for healthcare applicability.

  14. Clocks and cardiovascular function (United States)

    McLoughlin, Sarah C.; Haines, Philip; FitzGerald, Garret A.


    Circadian clocks in central and peripheral tissues enable the temporal synchronization and organization of molecular and physiological processes of rhythmic animals, allowing optimum functioning of cells and organisms at the most appropriate time of day. Disruption of circadian rhythms, from external or internal forces, leads to widespread biological disruption and is postulated to underlie many human conditions, such as the incidence and timing of cardiovascular disease. Here, we describe in vivo and in vitro methodology relevant to studying the role of circadian rhythms in cardiovascular function and dysfunction PMID:25707279

  15. Cardiovascular complications of cirrhosis

    DEFF Research Database (Denmark)

    Møller, S; Henriksen, Jens Henrik Sahl


    and electrophysiological abnormalities, an entity that is different from alcoholic heart muscle disease. Being clinically latent, cirrhotic cardiomyopathy can be unmasked by physical or pharmacological strain. Consequently, caution should be exercised in the case of stressful procedures, such as large volume paracentesis......Cardiovascular complications of cirrhosis include cardiac dysfunction and abnormalities in the central, splanchnic and peripheral circulation, and haemodynamic changes caused by humoral and nervous dysregulation. Cirrhotic cardiomyopathy implies systolic and diastolic dysfunction....... The clinical significance of cardiovascular complications and cirrhotic cardiomyopathy is an important topic for future research, and the initiation of new randomised studies of potential treatments for these complications is needed....

  16. Cardiovascular complications of cirrhosis

    DEFF Research Database (Denmark)

    Møller, Søren; Henriksen, Jens Henrik


    and electrophysiological abnormalities, an entity that is different from alcoholic heart muscle disease. Being clinically latent, cirrhotic cardiomyopathy can be unmasked by physical or pharmacological strain. Consequently, caution should be exercised in the case of stressful procedures, such as large volume paracentesis......Cardiovascular complications of cirrhosis include cardiac dysfunction and abnormalities in the central, splanchnic and peripheral circulation, and haemodynamic changes caused by humoral and nervous dysregulation. Cirrhotic cardiomyopathy implies systolic and diastolic dysfunction....... The clinical significance of cardiovascular complications and cirrhotic cardiomyopathy is an important topic for future research, and the initiation of new randomised studies of potential treatments for these complications is needed.  ...

  17. Envejecimiento del sistema cardiovascular



    Las principales características del envejecimiento del sistema cardiovascular reflejan cambios anatómicos y estructurales a nivel de la pared de los vasos, la relajación miocárdica, el llenado ventricular y la respuesta a las catecolaminas . Muchos de los cambios funcionales asociados con la edad están relacionados con estos fenómenos. Esta revisión describe los cambios relacionados con el envejecimiento a nivel estructural y funcional del sistema cardiovascular, sus posibles factores etiológ...

  18. Pharmacogenomics and cardiovascular disease

    DEFF Research Database (Denmark)

    Weeke, Peter; Roden, Dan M


    Variability in drug responsiveness is a sine qua non of modern therapeutics, and the contribution of genomic variation is increasingly recognized. Investigating the genomic basis for variable responses to cardiovascular therapies has been a model for pharmacogenomics in general and has established...... resulted in changes to the product labels but also have led to development of initial clinical guidelines that consider how to facilitate incorporating genetic information to the bedside. This review summarizes the state of knowledge in cardiovascular pharmacogenomics and considers how variants described...

  19. Research in cardiovascular care

    DEFF Research Database (Denmark)

    Jaarsma, Tiny; Deaton, Christi; Fitzsimmons, Donna


    To deliver optimal patient care, evidence-based care is advocated and research is needed to support health care staff of all disciplines in deciding which options to use in their daily practice. Due to the increasing complexity of cardiac care across the life span of patients combined...... of the body of knowledge that is needed to further improve cardiovascular care. In this paper, knowledge gaps in current research related to cardiovascular patient care are identified, upcoming challenges are explored and recommendations for future research are given....

  20. Myeloperoxidase and cardiovascular disease. (United States)

    Nicholls, Stephen J; Hazen, Stanley L


    Myeloperoxidase (MPO) is a leukocyte-derived enzyme that catalyzes the formation of a number of reactive oxidant species. In addition to being an integral component of the innate immune response, evidence has emerged that MPO-derived oxidants contribute to tissue damage during inflammation. MPO-catalyzed reactions have been attributed to potentially proatherogenic biological activities throughout the evolution of cardiovascular disease, including during initiation, propagation, and acute complication phases of the atherosclerotic process. As a result, MPO and its downstream inflammatory pathways represent attractive targets for both prognostication and therapeutic intervention in the prophylaxis of atherosclerotic cardiovascular disease.

  1. Improved Accuracy of the Inherent Shrinkage Method for Fast and More Reliable Welding Distortion Calculations (United States)

    Mendizabal, A.; González-Díaz, J. B.; San Sebastián, M.; Echeverría, A.


    This paper describes the implementation of a simple strategy adopted for the inherent shrinkage method (ISM) to predict welding-induced distortion. This strategy not only makes it possible for the ISM to reach accuracy levels similar to the detailed transient analysis method (considered the most reliable technique for calculating welding distortion) but also significantly reduces the time required for these types of calculations. This strategy is based on the sequential activation of welding blocks to account for welding direction and transient movement of the heat source. As a result, a significant improvement in distortion prediction is achieved. This is demonstrated by experimentally measuring and numerically analyzing distortions in two case studies: a vane segment subassembly of an aero-engine, represented with 3D-solid elements, and a car body component, represented with 3D-shell elements. The proposed strategy proves to be a good alternative for quickly estimating the correct behaviors of large welded components and may have important practical applications in the manufacturing industry.

  2. Personal utility is inherent to direct-to-consumer genomic testing. (United States)

    Chung, Matthew Wai Heng; Ng, Joseph Chi Fung


    People for and against direct-to-consumer (DTC) genomic tests are arguing around two issues: first, on whether an autonomy-based account can justify the tests; second, on whether the tests bring any personal utility. Bunnik et al, in an article published in this journal, were doubtful on the latter, especially in clinically irrelevant and uninterpretable sequences, and how far this claim could go in the justification. Here we argue that personal utility is inherent to DTC genomic tests and their results. We discuss Bunnik et al's account of personal utility and identify problems in its motivation and application. We then explore concepts like utility and entertainment which suggest that DTC genomic tests bring personal utility to their consumers, both in the motivation and the content of the tests. This points to an alternative account of personal utility which entails that entertainment value alone is adequate to justify DTC genomic tests, given appropriate strategies to communicate tests results with the consumers. It supports the autonomy-based justification of the test by showing that DTC genomic test itself stands as a valuable option and facilitates meaningful choice of the people.

  3. A random optimization approach for inherent optic properties of nearshore waters (United States)

    Zhou, Aijun; Hao, Yongshuai; Xu, Kuo; Zhou, Heng


    Traditional method of water quality sampling is time-consuming and highly cost. It can not meet the needs of social development. Hyperspectral remote sensing technology has well time resolution, spatial coverage and more general segment information on spectrum. It has a good potential in water quality supervision. Via the method of semi-analytical, remote sensing information can be related with the water quality. The inherent optical properties are used to quantify the water quality, and an optical model inside the water is established to analysis the features of water. By stochastic optimization algorithm Threshold Acceptance, a global optimization of the unknown model parameters can be determined to obtain the distribution of chlorophyll, organic solution and suspended particles in water. Via the improvement of the optimization algorithm in the search step, the processing time will be obviously reduced, and it will create more opportunity for the increasing the number of parameter. For the innovation definition of the optimization steps and standard, the whole inversion process become more targeted, thus improving the accuracy of inversion. According to the application result for simulated data given by IOCCG and field date provided by NASA, the approach model get continuous improvement and enhancement. Finally, a low-cost, effective retrieval model of water quality from hyper-spectral remote sensing can be achieved.

  4. Impact of operational model nesting approaches and inherent errors for coastal simulations (United States)

    Brown, Jennifer M.; Norman, Danielle L.; Amoudry, Laurent O.; Souza, Alejandro J.


    A region of freshwater influence (ROFI) under hypertidal conditions is used to demonstrate inherent problems for nested operational modelling systems. Such problems can impact the accurate simulation of freshwater export within shelf seas, so must be considered in coastal ocean modelling studies. In Liverpool Bay (our UK study site), freshwater inflow from 3 large estuaries forms a coastal front that moves in response to tides and winds. The cyclic occurrence of stratification and remixing is important for the biogeochemical cycles, as nutrient and pollutant loaded freshwater is introduced into the coastal system. Validation methods, using coastal observations from fixed moorings and cruise transects, are used to assess the simulation of the ROFI, through improved spatial structure and temporal variability of the front, as guidance for best practise model setup. A structured modelling system using a 180 m grid nested within a 1.8 km grid demonstrates how compensation for error at the coarser resolution can have an adverse impact on the nested, high resolution application. Using 2008, a year of typical calm and stormy periods with variable river influence, the sensitivities of the ROFI dynamics to initial and boundary conditions are investigated. It is shown that accurate representation of the initial water column structure is important at the regional scale and that the boundary conditions are most important at the coastal scale. Although increased grid resolution captures the frontal structure, the accuracy in frontal position is determined by the offshore boundary conditions and therefore the accuracy of the coarser regional model.

  5. Generalized Ocean Color Inversion Model for Retrieving Marine Inherent Optical Properties (United States)

    Werdell, P. Jeremy; Franz, Bryan A.; Bailey, Sean W.; Feldman, Gene C.; Boss, Emmanuel; Brando, Vittorio E.; Dowell, Mark; Hirata, Takafumi; Lavender, Samantha J.; Lee, ZhongPing; Loisel, Hubert; Maritorena, Stephane; Melin, Frederic; Moore, Timothy S.; Smyth, TImothy J.; Antoine, David; Devred, Emmanuel; Fantond'Andon, Odile Hembise; Mangin, Antoine


    Ocean color measured from satellites provides daily, global estimates of marine inherent optical properties (IOPs). Semi-analytical algorithms (SAAs) provide one mechanism for inverting the color of the water observed by the satellite into IOPs. While numerous SAAs exist, most are similarly constructed and few are appropriately parameterized for all water masses for all seasons. To initiate community-wide discussion of these limitations, NASA organized two workshops that deconstructed SAAs to identify similarities and uniqueness and to progress toward consensus on a unified SAA. This effort resulted in the development of the generalized IOP (GIOP) model software that allows for the construction of different SAAs at runtime by selection from an assortment of model parameterizations. As such, GIOP permits isolation and evaluation of specific modeling assumptions, construction of SAAs, development of regionally tuned SAAs, and execution of ensemble inversion modeling. Working groups associated with the workshops proposed a preliminary default configuration for GIOP (GIOP-DC), with alternative model parameterizations and features defined for subsequent evaluation. In this paper, we: (1) describe the theoretical basis of GIOP; (2) present GIOP-DC and verify its comparable performance to other popular SAAs using both in situ and synthetic data sets; and, (3) quantify the sensitivities of their output to their parameterization. We use the latter to develop a hierarchical sensitivity of SAAs to various model parameterizations, to identify components of SAAs that merit focus in future research, and to provide material for discussion on algorithm uncertainties and future ensemble applications.

  6. Influence of the inherent properties of drinking water treatment residuals on their phosphorus adsorption capacities. (United States)

    Bai, Leilei; Wang, Changhui; He, Liansheng; Pei, Yuansheng


    Batch experiments were conducted to investigate the phosphorus (P) adsorption and desorption on five drinking water treatment residuals (WTRs) collected from different regions in China. The physical and chemical characteristics of the five WTRs were determined. Combined with rotated principal component analysis, multiple regression analysis was used to analyze the relationship between the inherent properties of the WTRs and their P adsorption capacities. The results showed that the maximum P adsorption capacities of the five WTRs calculated using the Langmuir isotherm ranged from 4.17 to 8.20mg/g at a pH of 7 and further increased with a decrease in pH. The statistical analysis revealed that a factor related to Al and 200 mmol/L oxalate-extractable Al (Alox) accounted for 36.5% of the variations in the P adsorption. A similar portion (28.5%) was attributed to an integrated factor related to the pH, Fe, 200 mmol/L oxalate-extractable Fe (Feox), surface area and organic matter (OM) of the WTRs. However, factors related to other properties (Ca, P and 5 mmol/L oxalate-extractable Fe and Al) were rejected. In addition, the quantity of P desorption was limited and had a significant negative correlation with the (Feox+Alox) of the WTRs (p<0.05). Overall, WTRs with high contents of Alox, Feox and OM as well as large surface areas were proposed to be the best choice for P adsorption in practical applications.

  7. Computability, Gödel's incompleteness theorem, and an inherent limit on the predictability of evolution. (United States)

    Day, Troy


    The process of evolutionary diversification unfolds in a vast genotypic space of potential outcomes. During the past century, there have been remarkable advances in the development of theory for this diversification, and the theory's success rests, in part, on the scope of its applicability. A great deal of this theory focuses on a relatively small subset of the space of potential genotypes, chosen largely based on historical or contemporary patterns, and then predicts the evolutionary dynamics within this pre-defined set. To what extent can such an approach be pushed to a broader perspective that accounts for the potential open-endedness of evolutionary diversification? There have been a number of significant theoretical developments along these lines but the question of how far such theory can be pushed has not been addressed. Here a theorem is proven demonstrating that, because of the digital nature of inheritance, there are inherent limits on the kinds of questions that can be answered using such an approach. In particular, even in extremely simple evolutionary systems, a complete theory accounting for the potential open-endedness of evolution is unattainable unless evolution is progressive. The theorem is closely related to Gödel's incompleteness theorem, and to the halting problem from computability theory.

  8. The cardiovascular exosome: current perspectives and potential. (United States)

    Cosme, Jake; Liu, Peter P; Gramolini, Anthony O


    The exosome is a secreted microvesicle that has been shown to contain genetic material and proteins and is involved in multiple levels of cellular communication. The cardiovascular exosome proteome is a promising subproteome that warrants investigation since a detailed understanding of its role in the heart should improve our comprehension of intercellular communication in the heart, and may even assist in biomarker discovery. Indeed, uncovering the role of the exosome in cardiovascular physiology could be accomplished with the application of scientific approaches and insights gained from studies of exosomes in other fields, such as cancer biology and immunology, where much of the established knowledge of the exosome has been generated. In the present review, we discuss the relevant literature and examine areas of investigation that would bring the cardiovascular exosome to the forefront of intercellular communication in the heart.

  9. Progress in clinical application of red blood cell distribution width in cardiovascular diseases%红细胞分布宽度在心血管疾病的临床应用进展

    Institute of Scientific and Technical Information of China (English)

    王钢; 华琦


    红细胞分布宽度(RDW)是测定血液循环中红细胞体积大小是否具有均一性、形态可变性和大小变异性的一个指标,常结合红细胞平均体积用于诊断贫血。研究表明RDW升高可以在心血管疾病的预测及诊断中提供有价值的线索。本篇综述介绍RDW在心血管疾病中的临床应用。%The red blood cell distribution width (RDW) is a measure of the variation of red blood cell (RBC, also known as erythrocytes), which is typically used in combination with mean corpuscular volume to diagnose anemia. Recently, a number of studies have shown that an increased RDW is a strong and independent predictor of prognosis in cardiovascular disease (CVD). Although the mechanism is still unclear, nevertheless, RDW is an easy, inexpensive, and routinely reported test which might supply diagnostic and prognostic information for patients with CVD. This article reviewed the promising progress in RDW application in cardiovascular disease.

  10. Pharmacogenetics of cardiovascular drugs. (United States)

    Johnson, Julie A; Humma, Larisa M


    Pharmacogenetics is a field aimed at understanding the genetic contribution to inter-patient variability in drug efficacy and toxicity. Treatment of cardiovascular disease is, in most cases, guided by evidence from well-controlled clinical trials. Given the solid scientific basis for the treatment of most cardiovascular diseases, it is common for patients with a given disease to be treated in essentially the same manner. Thus, the clinical trials have been very informative about treating large groups of patients with a given disease, but are slightly less informative about the treatment of individual patients. Pharmacogenetics and pharmacogenomics have the potential of taking the information derived from large clinical trials and further refining it to select the drugs with the greatest likelihood for benefit, and least likelihood for harm, in individual patients, based on their genetic make-up. In this paper, the current literature on cardiovascular pharmacogenetics is emphasised, and how the use of pharmacogenetic/pharmacogenomic information may be particularly useful in the future in the treatment of cardiovascular diseases is also highlighted.

  11. Cheese and cardiovascular health

    DEFF Research Database (Denmark)

    Hjerpsted, Julie Bousgaard

    Cardiovascular diseases (CVDs) are the number one cause of mortality worldwide. Low-density lipoprotein (LDL) cholesterol is a well-known risk factor of CVD which increases after the intake of saturated fatty acids (SFA). Cheese is a dietary product commonly consumed in Western countries and known...

  12. Cardiovascular effects of gliptins. (United States)

    Scheen, André J


    Dipeptidyl peptidase 4 (DPP-4) inhibitors (commonly referred to as gliptins) are a novel class of oral antihyperglycaemic agents with demonstrated efficacy in the treatment of type 2 diabetes mellitus (T2DM). Preclinical data and mechanistic studies have indicated a possible beneficial action on blood vessels and the heart, via both glucagon-like peptide 1 (GLP-1)-dependent and GLP-1-independent effects. DPP-4 inhibition increases the concentration of many peptides with potential vasoactive and cardioprotective effects. Clinically, DPP-4 inhibitors improve several risk factors in patients with T2DM. They improve blood glucose control (mainly by reducing postprandial glycaemia), are weight neutral (or even induce modest weight loss), lower blood pressure, improve postprandial lipaemia, reduce inflammatory markers, diminish oxidative stress, and improve endothelial function. Some positive effects on the heart have also been described in patients with ischaemic heart disease or congestive heart failure, although their clinical relevance requires further investigation. Post-hoc analyses of phase II-III, controlled trials suggest a possible cardioprotective effect with a trend for a lower incidence of major cardiovascular events with gliptins than with placebo or active agents. However, the actual relationship between DPP-4 inhibition and cardiovascular outcomes remains to be proven. Major prospective clinical trials with predefined cardiovascular outcomes and involving various DPP-4 inhibitors are now underway in patients with T2DM and a high-risk cardiovascular profile.

  13. Neuropeptides in cardiovascular control. (United States)

    Ganong, W F


    Neuropeptides can affect cardiovascular function in various ways. They can serve as cotransmitters in the autonomic nervous system; for example, vasoactive intestinal peptide (VIP) is released with acetylcholine and neuropeptide Y with norepinephrine from postganglionic neurons. Substance P and, presumably, other peptides can can affect cardiovascular function when released near blood vessels by antidromically conducted impulses in branches of stimulated sensory neurons. In the central nervous system, many different neuropeptides appear to function as transmitters or contransmittes in the neural pathways that regulate the cardiovascular system. In addition neuropeptides such as vasopressin and angiotensin II also circulate as hormones that are involved in cardiovascular control. Large doses of exogenous vasopressin are required to increase blood pressure in normal animals because the increase in total peripheral resistance produced by the hormones is accompanied by a decrease in cardiac output. However, studies with synthetic peptides that selectively antagonize the vasopressor action of vasopressin indicate that circulating vasopressin is important in maintaining blood pressure when animals are hypovolemic due to dehydration, haemorrhage or adrenocortical insufficiency. VIP dilates blood vessels and stimulates renin secretion by a direct action on the juxtaglomerular cells. Renin secretion is stimulated when the concentration of VIP in plasma exceeds 75 pmol/litre, and higher values are seen in a number of conditions. Neostigmine, a drug which increases the secretion of endogenous VIP, also increases renin secretion, and this increase is not blocked by renal denervation or propranolol. Thus, VIP may be a physiologically significant renin stimulating hormone.(ABSTRACT TRUNCATED AT 250 WORDS)

  14. Epigenetics and cardiovascular disease (United States)

    Despite advances in the prevention and management of cardiovascular disease (CVD), this group of multifactorial disorders remains a leading cause of mortality worldwide. CVD is associated with multiple genetic and modifiable risk factors; however, known environmental and genetic influences can only...

  15. SWAD: inherent photon counting performance of amorphous selenium multi-well avalanche detector (United States)

    Stavro, Jann; Goldan, Amir H.; Zhao, Wei


    Photon counting detectors (PCDs) have the potential to improve x-ray imaging, however they are still hindered by several performance limitations and high production cost. By using amorphous Selenium (a-Se) the cost of PCDs can be significantly reduced compared to crystalline materials and enable large area detector fabrication. To overcome the problem of low carrier mobility and low charge conversion gain in a-Se, we are developing a novel direct conversion a- Se field-Shaping multi-Well Avalanche Detector (SWAD). SWAD circumvents the charge transport limitation by using a Frisch grid built within the readout circuit, reducing charge collection time to ~200 ns. Field shaping permits depth independent avalanche gain in wells, resulting in total conversion gain that is comparable to Si and CdTe. In the present work we investigate the effects of charge sharing and energy loss to understand the inherent photon counting performance for SWAD at x-ray energies used in breast imaging applications (20-50keV). The energy deposition profile for each interacting x-ray was determined with Monte Carlo simulation. For the energy ranges we are interested in, photoelectric interaction dominates, with a k-fluorescence yield of approximately 60%. Using a monoenergetic 45 keV beam incident on a target pixel in 400um of a-Se, our results show that only 20.42 % and 22.4 % of primary interacting photons have kfluorescence emissions which escape the target pixel for 100um and 85um pixel sizes respectively, demonstrating SWAD's potential for high spatial resolution applications.

  16. The Cardiovascular Research Grid (CVRG) (United States)

    U.S. Department of Health & Human Services — The CardioVascular Research Grid (CVRG) project is creating an infrastructure for sharing cardiovascular data and data analysis tools. CVRG tools are developed using...

  17. Novel OSNR Monitoring Technique in Dense WDM Systems using Inherently Generated CW Monitoring Channels

    DEFF Research Database (Denmark)

    Petersen, Martin Nordal


    We present a simple, yet effective OSNR monitoring technique based on an inherent effect in the optical modulator. Highly accurate OSNR monitoring is demonstrated in a 40 Gb/s dense WDM system with 50 GHz channel spacing....

  18. ATC Taskload Inherent to the Geometry of Stochastic 4-D Trajectory Flows with Flight Technical Errors (United States)

    National Aeronautics and Space Administration — A method to quantify the probabilistic controller taskload inherent to maintaining aircraft adherence to 4-D trajectories within flow corridors is presented. An...

  19. Personalized medicine in cardiovascular diseases. (United States)

    Lee, Moo-Sik; Flammer, Andreas J; Lerman, Lilach O; Lerman, Amir


    Personalized medicine is a novel medical model with all decisions and practices being tailored to individual patients in whatever ways possible. In the era of genomics, personalized medicine combines the genetic information for additional benefit in preventive and therapeutic strategies. Personalized medicine may allow the physician to provide a better therapy for patients in terms of efficiency, safety and treatment length to reduce the associated costs. There was a remarkable growth in scientific publication on personalized medicine within the past few years in the cardiovascular field. However, so far, only very few cardiologists in the USA are incorporating personalized medicine into clinical treatment. We review the concepts, strengths, limitations and challenges of personalized medicine with a particular focus on cardiovascular diseases (CVDs). There are many challenges from both scientific and policy perspectives to personalized medicine, which can overcome them by comprehensive concept and understanding, clinical application, and evidence based practices. Individualized medicine serves a pivotal role in the evolution of national and global healthcare reform, especially, in the CVDs fields. Ultimately, personalized medicine will affect the entire landscape of health care system in the near future.

  20. Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

    Directory of Open Access Journals (Sweden)

    Vellayappan MV


    Full Text Available Muthu Vignesh Vellayappan,1 Arunpandian Balaji,1 Aruna Priyadarshini Subramanian,1 Agnes Aruna John,1 Saravana Kumar Jaganathan,1 Selvakumar Murugesan,2 Eko Supriyanto,1 Mustafa Yusof1 1IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia; 2Rubber Technology Center, Indian Institute of Technology, Kharagpur, India Abstract: Cardiovascular disease is the leading cause of death across the globe. The use of synthetic materials is indispensable in the treatment of cardiovascular disease. Major drawbacks related to the use of biomaterials are their mechanical properties and biocompatibility, and these have to be circumvented before promoting the material to the market or clinical setting. Revolutionary advancements in nanotechnology have introduced a novel class of materials called nanocomposites which have superior properties for biomedical applications. Recently, there has been a widespread recognition of the nanocomposites utilizing polyhedral oligomeric silsesquioxane, bacterial cellulose, silk fibroin, iron oxide magnetic nanoparticles, and carbon nanotubes in cardiovascular grafts and stents. The unique characteristics of these nanocomposites have led to the development of a wide range of nanostructured copolymers with appreciably enhanced properties, such as improved mechanical, chemical, and physical characteristics suitable for cardiovascular implants. The incorporation of advanced nanocomposite materials in cardiovascular grafts and stents improves hemocompatibility, enhances antithrombogenicity, improves mechanical and surface properties, and decreases the microbial response to the cardiovascular implants. A thorough attempt is made to summarize the various applications of nanocomposites for cardiovascular graft and stent applications. This review will highlight the recent advances in nanocomposites and also address the need of future research in

  1. Nonfasting hyperlipidemia and cardiovascular disease

    DEFF Research Database (Denmark)

    Nordestgaard, B G; Langsted, A; Freiberg, J J


    , total cholesterol/HDL cholesterol, and apolipoprotein B/apolipoprotein A1 all associate with increased risk of cardiovascular disease. These new data open the possibility that nonfasting rather than fasting lipid profiles can be used for cardiovascular risk prediction. If implemented, this would...... of cardiovascular disease and early death....


    Kuzminova, J A; Plyasunova, S A; Jogov, V V; Smetanina, N S


    The laboratory diagnostic of inherent spherocytosis is based on detection of spherocytes in peripheral blood, decreasing of index of sphericity, decreasing of osmotic resistance of erythrocytes. The new test of diagnostic of hereditary spherocytosis build on molecular defect was developed on the basis of binding extracellular fragments of protein of band 3 with eosin-5-maleimide (EMA-test). The study was carried out to implement comparative analysis of sensitivity and specificity of techniques applied to diagnose inherent spherocytosis. The sampling of 94 patients with various forms of anemias was analyzed All patients were applied complex clinical laboratory examination including analysis of osmotic resistance of erythrocytes, erythrocytometry and EMA-test as specific techniques of diagnostic of inherent spherocytosis. In 51 out of 94 patients (54%) decreasing of values of EMA-test was detected and in 47 patients diagnosis of inherent spherocytosis was confirmed. The standard values of EMA-test were established in 43 patients (46%) and 12 patients out of them with established diagnosis of inherent spherocytosis. Therefore, sensitivity of EMA-test made up to 79% and specificity - 80%. The most sensitive techniques of diagnostic remain osmotic resistance of erythrocytes (91%) and index of sphericity (up to 96%). But the highest specificity in this respect has EMA-test (80%). Nowadays, none of implemented techniques of diagnostic of inherent spherocytosis can be applied as a universal one. The implementation of complex examination is needed for proper diagnostic of disease.

  3. The cardiovascular system, as understood in antiquity

    Directory of Open Access Journals (Sweden)

    Louise Cilliers


    Full Text Available Cardiovascular concepts in antiquity were primitive up to the early 5th century BC, when Greek philosopher-physicians like Empedocles and Diogenes divorced human physiology from its previous magico-religious base in order to find answers in the natural sciences. The heart was not initially seen as central to the cardiovascular system – blood (containing life-giving pneuma moved through the body in blood vessels (phlebes by way of a spontaneous “ebb and flow” motion. Their perceived anatomical vascular models were quite fanciful, but nevertheless accepted by the Hippocratic doctors, who, except for a single work, The heart (containing a useful description of the heart, added little of significance to the subject. Based on animal dissections, post-Hippocratic authors like Diocles and Praxagoras first distinguished between arteries and veins, confirmed that the heart had two main chambers (ventricles and extended the theory that “innate heat” in the left ventricle produced pneuma which filled the arteries; only veins contained blood, produced in the right ventricle. Basing their theories on human dissections the Alexandrians, Herophilus and Erasistratus (3rd century BC produced the first accurate descriptions of the heart and major components of the vascular system. Erasistratus even postulated minute (normally non-functional peripheral arterio-venous anastomoses. The heart’s pump function was only partially understood – diastole was seen as the active phase of the cardiac cycle (sucking blood into the heart, and the pulse as inherent contraction of the arterial wall. After Herophilus and Erasistratus human dissection ceased, putting an end to further significant developments in unravelling the cardiovascular system. In the 2nd century AD, Celsus consolidated known knowledge, even adding minor contributions (e.g. a description of the coronary vessels based on his own animal dissections. He mainly confirmed the Alexandrians’ findings

  4. Myocardial dysfunction and cardiovascular disease in type 2 diabetes. (United States)

    Ofstad, Anne Pernille


    Type 2 diabetes mellitus (T2DM) is strongly associated with increased risk of myocardial dysfunction and cardiovascular disease (CVD), two separate conditions which often co-exist and influence each other's course. The prevalence of myocardial dysfunction may be as high as 75% in T2DM populations but is often overlooked due to the initial asymptomatic nature of the disease, complicating co-morbidities such as coronary artery disease (CAD) and obesity, and the lack of consensus on diagnostic criteria. More sensitive echocardiographic applications are furthermore needed to improve detection of early subclinical changes in myocardial function which do not affect conventional echocardiographic parameters. The pathophysiology of the diabetic myocardial dysfunction is not fully elucidated, but involves hyperglycemia and high levels of free fatty acids. It evolves over several years and increases the risk of developing overt HF, and is suggested to at least in part account for the worse outcome seen in T2DM individuals after cardiac events. CAD and stroke are the most frequent CV manifestations among T2DM patients and relate to a large degree to the accelerated atherosclerosis driven by inflammation. Diagnosing CAD is challenging due to the lower sensitivity inherent in the diagnostic tests and there is thus a need for new biomarkers to improve prediction and detection of CAD. It seems that a multi-factorial approach (i.e. targeting several CV risk factors simultaneously) is superior to a strict glucose lowering strategy in reducing risk for macrovascular events, and recent research may even support an effect also on HF outcomes.

  5. 循证医学在心血管教学中的应用研究%Application of evidence-based medicine in cardiovascular teaching

    Institute of Scientific and Technical Information of China (English)

    娜几娜·吾格提; 王坤; 迪力努尔·塔吉; 赵利; 艾力曼·马合木提


    Objective:To investigate the effect of Evidence-based medicine teaching practice in the teaching of cardiovascular disease. Methods:Clinical Cardiology selected 97 student interns, EBM were randomly divided into two groups, which EBM group 49, control group 48. EBM group with evidence-based medicine teaching unit group, the control group using traditional teaching methods. Results:EBM group, the average score was (79.45 ± 7.30) points, the average score in the control group (67.92 ± 6.87) points, including clinical skills assessment score in the EBM group (10.73 ± 4.76) points, the score of the control group (9.45 ± 5.78) points, there was a significant difference (P<0.05) between the two. Conclusions:Evidence-based medicine theory in cardiovascular disease teaching has a good effect, with a certain value.%目的:探讨心血管疾病教学中开展循证医学教学的实践效果。方法:选取临床心内科实习学生97名,采用随机分组的原则分为EBM组和对照组,其中EBM组49名,对照组48名。EBM组采用小组单位循证医学教学,对照组采用传统教学方法,比较两组在心血管疾病教学中的成绩和临床技能考核分数。结果:通过实验显示E B M组平均成绩为(79.45±7.30)分,对照组平均成绩(67.92±6.87)分,其中临床技能考核中E B M组成绩为(10.73±4.76)分,对照组成绩为(9.45±5.78)分,通过t检验,两者间存在显著性差异(P<0.05),E B M组成绩要优于对照组。结论:循证医学理论在心血管疾病教学的应用具有很好的效果,具有一定的应用价值。

  6. [Multiculturalism and cardiovascular diseases]. (United States)

    Gaudio, Carlo; Corsi, Filippo; Esposito, Cosimo; Di Michele, Sara; Nguyen, Bich Lien; Khatibi, Shahrzad; Sciarretta, Tesir; Franchitto, Silvia; Mirabelli, Francesca; Pannarale, Giuseppe


    Immigration has increased drastically to the point of becoming an ordinary structure of our society. Once in Italy, the immigrant's health is compromised rapidly due to a series of conditions and illnesses that exist in our country: lack of work, inadequate salary, inappropriate residence, lacking family support, climate changes, nutritional differences. Cardiovascular illnesses represent 7.6% of the diseases of the immigrants, and cause 36.6% of deaths. The risk factors that affect the genesis of cardiovascular diseases include: subjective factors (age, ethnic group), environmental, nutritional and pathological (arterial hypertension, AIDS, tuberculosis, alcohol). The challenge for our time is to design a new solidarity model to promote cultural and social integration in order to meet the multiethnical and multiracial needs of western society. This model should permit reconsideration of doctor-patient relationship in order to build a real intercultural society.

  7. Migraine and cardiovascular disease

    Directory of Open Access Journals (Sweden)

    Marcelo E. Bigal


    Full Text Available Migraine, especially migraine with aura is an established risk factor for ischemic lesions of the brain. Recent evidence has also linked migraine with and without aura to a broader range of ischemic vascular disorders including angina, myocardial infarction, coronary revascularization, claudication and cardiovascular mortality. The topic is therefore of considerable interest. Accordingly, herein we review the association between migraine and cardiovascular disease. We start by briefly presenting diagnostic criteria for migraine and revising its pathophysiology. We follow by summarizing the evidence on the topic. We then briefly present the results of a recent meta-analysis. We close by highlighting results of a large epidemiological study conducted after the publication of the meta-analysis.

  8. Prodrugs in Cardiovascular Therapy

    Directory of Open Access Journals (Sweden)

    Maryam Tabrizian


    Full Text Available Prodrugs are biologically inactive derivatives of an active drug intended to solve certain problems of the parent drug such as toxicity, instability, minimal solubility and non-targeting capabilities. The majority of drugs for cardiovascular diseases undergo firstpass metabolism, resulting in drug inactivation and generation of toxic metabolites, which makes them appealing targets for prodrug design. Since prodrugs undergo a chemical reaction to form the parent drug once inside the body, this makes them very effective in controlling the release of a variety of compounds to the targeted site. This review will provide the reader with an insight on the latest developments of prodrugs that are available for treating a variety of cardiovascular diseases. In addition, we will focus on several drug delivery methodologies that have merged with the prodrug approach to provide enhanced target specificity and controlled drug release with minimal side effects.

  9. Slow breathing and cardiovascular disease

    Directory of Open Access Journals (Sweden)

    Ashish Chaddha


    Full Text Available Cardiovascular disease is the leading cause of death for both men and women worldwide. Much emphasis has been placed on the primary and secondary prevention of cardiovascular disease. While depression and anxiety increase the risk of developing cardiovascular disease, cardiovascular disease also increases the risk of developing anxiety and depression. Thus, promoting optimal mental health may be important for both primary and secondary prevention of cardiovascular disease. Like lowering blood pressure, lipids, and body weight, lowering anger and hostility and improving depression and anxiety may also be an important intervention in preventive cardiology. As we strive to further improve cardiovascular outcomes, the next bridge to cross may be one of offering patients nonpharmacologic means for combating daily mental stress and promoting mental health, such as yoga and pranayama. Indeed, the best preventive cardiovascular medicine may be a blend of both Western and Eastern medicine.

  10. Slow breathing and cardiovascular disease. (United States)

    Chaddha, Ashish


    Cardiovascular disease is the leading cause of death for both men and women worldwide. Much emphasis has been placed on the primary and secondary prevention of cardiovascular disease. While depression and anxiety increase the risk of developing cardiovascular disease, cardiovascular disease also increases the risk of developing anxiety and depression. Thus, promoting optimal mental health may be important for both primary and secondary prevention of cardiovascular disease. Like lowering blood pressure, lipids, and body weight, lowering anger and hostility and improving depression and anxiety may also be an important intervention in preventive cardiology. As we strive to further improve cardiovascular outcomes, the next bridge to cross may be one of offering patients nonpharmacologic means for combating daily mental stress and promoting mental health, such as yoga and pranayama. Indeed, the best preventive cardiovascular medicine may be a blend of both Western and Eastern medicine.

  11. A Bayesian based quasi-analytical algorithm for retrieval of inherent optical properties from ocean color

    Institute of Scientific and Technical Information of China (English)

    ZHAN Haigang; SHI Ping; CHEN Chuqun


    The recently developed quasi-analytical algorithm (QAA) is a promising algorithm for deriving inherent optical properties from ocean color. Unlike the conventional semi-analytical algorithm, QAA does not need a priori knowledge of the spectral shape of chlorophyll absorption. However, several empirical relations, which may not be universally applicable and can result in low noise tolerance, are involved in QAA. In this study, the Bayesian inversion theory is introduced to improve the performance of QAA. In the estimation of total absorption coefficient at the reference wavelength, instead of empirical algorithms used in the QAA, the Bayesian approach is employed in combination with an optical model that uses separate parameters to account explicitly for the contribution of molecular and particle scatterings to remote sensing reflectance, a priori knowledge produced by the QAA, the Akaike's Bayesian information criterion (ABIC) for choosing the optimal regularization parameter, and genetic algorithms for global optimization. Coefficients at other wavelengths are then derived using an empirical estimate of particle backscattering spectral shape. When applied to a simulated dataset synthesized by IOCCG, the Bayesian algorithm outperforms QAA algorithm, especially in higher chlorophyll concentration waters. The root mean square errors (RMSEs) between the true and the derived a(440) and bb(440) are reduced from 0.918 and 0.039 m-1 for QAA-555 to 0.367 and 0.023 m-1 for Bayes-555, 0.205 and 0.007 m-1 for QAA-640 to 0.092 and 0.005 m-1 for Bayes-640, and 0.207 and 0.007 m-1 for QAA-blending to 0.096 and 0.005 m-1 for Bayes-blending. Results of noise sensitivity analysis show that the Bayesian algorithm is more robust than QAA.

  12. Influence of the inherent properties of drinking water treatment residuals on their phosphorus adsorption capacities

    Institute of Scientific and Technical Information of China (English)

    Leilei Bai; Changhui Wang; Liansheng He; Yuansheng Pei


    Batch experiments were conducted to investigate the phosphorus (P) adsorption and desorption on five drinking water treatment residuals (WTRs) collected from different regions in China.The physical and chemical characteristics of the five WTRs were determined.Combined with rotated principal component analysis,multiple regression analysis was used to analyze the relationship between the inherent properties of the WTRs and their P adsorption capacities.The results showed that the maximum P adsorption capacities of the five WTRs calculated using the Langmuir isotherm ranged from 4.17 to 8.20 mg/g at a pH of 7 and further increased with a decrease in pH.The statistical analysis revealed that a factor related to Al and 200 mmol/L oxalate-extractable Al (Alox) accounted for 36.5% of the variations in the P adsorption.A similar portion (28.5%) was attributed to an integrated factor related to the pH,Fe,200 mmol/L oxalate-extractable Fe (Feox),surface area and organic matter (OM) of the WTRs.However,factors related to other properties (Ca,P and 5 mmol/L oxalate-extractable Fe and Al) were rejected.In addition,the quantity of P desorption was limited and had a significant negative correlation with the (Feox + Alox) of the WTRs (p < 0.05).Overall,WTRs with high contents of Alox,Feox and OM as well as large surface areas were proposed to be the best choice for P adsorption in practical applications.

  13. Cardiovascular risk prediction

    DEFF Research Database (Denmark)

    Graversen, Peter; Abildstrøm, Steen Z; Jespersen, Lasse


    (ECG) abnormalities, heart rate, family history (of ischaemic heart disease), body mass index (BMI), waist-hip ratio, walking duration and pace, leisure time physical activity, forced expiratory volume (FEV)1%pred, household income, education, vital exhaustion, high-density lipoprotein (HDL......AIM: European society of cardiology (ESC) guidelines recommend that cardiovascular disease (CVD) risk stratification in asymptomatic individuals is based on the Systematic Coronary Risk Evaluation (SCORE) algorithm, which estimates individual 10-year risk of death from CVD. We assessed...

  14. Epidemiology and prevention of cardiovascular disease: Quo vadis? (United States)

    De Backer, Guy


    With observational epidemiological studies it has been possible in the 1950-60 s to identify what has been called cardiovascular risk factors. The multifactorial origin of atherothrombotic cardiovascular disease has been elucidated and in multifactorial intervention trials it was demonstrated that lifestyle changes related to smoking, diet and exercise can prevent the incidence of premature cardiovascular events. The application of that knowledge at the level of the community has resulted in a reversal of the cardiovascular disease epidemic. More investment is needed in the prevention of the development of cardiovascular risk from childhood onwards. More studies are needed to examine the long-term effects of low-intensity exposure to environmental factors on the cardiovascular system using the most appropriate study design and biosensors. More epidemiological studies are needed to evaluate societal changes on cardiovascular disease. Given the actual knowledge on how to prevent cardiovascular disease there is a need for a shift from aetiological epidemiological research into preventive research.

  15. 多层螺旋CT在心血管疾病中的应用进展%Progress in Application of MSCT for Cardiovascular Disease

    Institute of Scientific and Technical Information of China (English)



    多层螺旋CT的发明是CT发展史上的一大飞跃,为CT在诊断、治疗冠状动脉粥样硬化性心脏病等心血管疾病中的应用带来了新的机遇,提供了无创的简易方法.多层螺旋CT在诊断冠状动脉粥样硬化性心脏病、主动脉夹层、心功能测定、肺栓塞、评估心房颤动射频消融术前及脑血管成像、肾动脉成像等方面发挥着越来越重要作用.%The invention of multislice spiral computer tomography ( MSCT) created new opportunities for diagnosing and treating coronary heart disease and other cardiovascular diseases. MSCT can be used in the diagnosis of coronary heart disease, heart aortic dissection determination, pulmonary embolism, evaluate atrial fibrillation radiofrequency ablation before and cerebral imaging, and renal artery imaging. This article is playing a more and more important role.

  16. Study of time reversibility/irreversibility of cardiovascular data: theoretical results and application to laser Doppler flowmetry and heart rate variability signals (United States)

    Humeau-Heurtier, Anne; Mahé, Guillaume; Chapeau-Blondeau, François; Rousseau, David; Abraham, Pierre


    Time irreversibility can be qualitatively defined as the degree of a signal for temporal asymmetry. Recently, a time irreversibility characterization method based on entropies of positive and negative increments has been proposed for experimental signals and applied to heart rate variability (HRV) data (central cardiovascular system (CVS)). The results led to interesting information as a time asymmetry index was found different for young subjects and elderly people or heart disease patients. Nevertheless, similar analyses have not yet been conducted on laser Doppler flowmetry (LDF) signals (peripheral CVS). We first propose to further investigate the above-mentioned characterization method. Then, LDF signals, LDF signals reduced to samples acquired during ECG R peaks (LDF_RECG signals) and HRV recorded simultaneously in healthy subjects are processed. Entropies of positive and negative increments for LDF signals show a nonmonotonic pattern: oscillations—more or less pronounced, depending on subjects—are found with a period matching the one of cardiac activity. However, such oscillations are not found with LDF_RECG nor with HRV. Moreover, the asymmetry index for LDF is markedly different from the ones of LDF_RECG and HRV. The cardiac activity may therefore play a dominant role in the time irreversibility properties of LDF signals.

  17. Is the inherent potential of maize roots efficient for soil phosphorus acquisition?

    Directory of Open Access Journals (Sweden)

    Yan Deng

    Full Text Available Sustainable agriculture requires improved phosphorus (P management to reduce the overreliance on P fertilization. Despite intensive research of root adaptive mechanisms for improving P acquisition, the inherent potential of roots for efficient P acquisition remains unfulfilled, especially in intensive agriculture, while current P management generally focuses on agronomic and environmental concerns. Here, we investigated how levels of soil P affect the inherent potential of maize (Zea mays L. roots to obtain P from soil. Responses of root morphology, arbuscular mycorrhizal colonization, and phosphate transporters were characterized and related to agronomic traits in pot and field experiments with soil P supply from deficiency to excess. Critical soil Olsen-P level for maize growth approximated 3.2 mg kg(-1, and the threshold indicating a significant environmental risk was about 15 mg kg(-1, which represented the lower and upper levels of soil P recommended in current P management. However, most root adaptations involved with P acquisition were triggered when soil Olsen-P was below 10 mg kg(-1, indicating a threshold for maximum root inherent potential. Therefore, to maintain efficient inherent potential of roots for P acquisition, we suggest that the target upper level of soil P in intensive agriculture should be reduced from the environmental risk threshold to the point maximizing the inherent potential of roots.

  18. Cardiovascular Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics for the Clinical Practitioner. (United States)

    Sleder, Anna T; Kalus, James; Lanfear, David E


    Current clinical cardiovascular practice requires a clinician to have a strong foundation in multiple aspects of pharmacology. Modern cardiovascular regimens are complex, and optimal management, application of evolving guidelines, and adoption of new therapies build off a more basic understanding of pharmacokinetics and pharmacodynamics. In addition, it is likely time to add a third pillar into this discussion, the expanding field of pharmacogenomics referring to the genetic influences on drug response. This field has increasing applications in medicine and clearly holds significant promise for cardiovascular disease management. Awareness of pharmacogenomic advances and the fundamentals of pharmacokinetics and pharmacodynamics can help the clinician more easily deliver great care. Here we attempt to briefly summarize and simplify key concepts of pharmacokinetics, pharmacodynamics, and pharmacogenomics relevant to the cardiovascular disease practitioner.

  19. Arrayed SU-8 polymer thermal actuators with inherent real-time feedback for actively modifying MEMS’ substrate warpage (United States)

    Wang, Xinghua; Xiao, Dingbang; Chen, Zhihua; Wu, Xuezhong


    This paper describes the design, fabrication and characterization of a batch-fabricated micro-thermal actuators array with inherent real-time self-feedback, which can be used to actively modify micro-electro-mechanical systems’ (MEMS’) substrate warpage. Arrayed polymer thermal actuators utilize SU-8 polymer (a thick negative photoresist) as a functional material with integrated Ti/Al film-heaters as a microscale heat source. The electro-thermo-mechanical response of a micro-fabricated actuator was measured. The resistance of the Al/Ti film resistor varies obviously with ambient temperature, which can be used as inherent feedback for observing real-time displacement of activated SU-8 bumps (0.43 μm Ω-1). Due to the high thermal expansion coefficient, SU-8 bumps tend to have relatively large deflection at low driving voltage and are very easily integrated with MEMS devices. Experimental results indicated that the proposed SU-8 polymer thermal actuators (array) are able to achieve accurate rectification of MEMS’ substrate warpage, which might find potential applications for solving stress-induced problems in MEMS.

  20. {sup 1}H NMR-based metabolic profiling reveals inherent biological variation in yeast and nematode model systems

    Energy Technology Data Exchange (ETDEWEB)

    Szeto, Samuel S. W.; Reinke, Stacey N.; Lemire, Bernard D., E-mail: [University of Alberta, Department of Biochemistry, School of Molecular and Systems Medicine (Canada)


    The application of metabolomics to human and animal model systems is poised to provide great insight into our understanding of disease etiology and the metabolic changes that are associated with these conditions. However, metabolomic studies have also revealed that there is significant, inherent biological variation in human samples and even in samples from animal model systems where the animals are housed under carefully controlled conditions. This inherent biological variability is an important consideration for all metabolomics analyses. In this study, we examined the biological variation in {sup 1}H NMR-based metabolic profiling of two model systems, the yeast Saccharomyces cerevisiae and the nematode Caenorhabditis elegans. Using relative standard deviations (RSD) as a measure of variability, our results reveal that both model systems have significant amounts of biological variation. The C. elegans metabolome possesses greater metabolic variance with average RSD values of 29 and 39%, depending on the food source that was used. The S. cerevisiae exometabolome RSD values ranged from 8% to 12% for the four strains examined. We also determined whether biological variation occurs between pairs of phenotypically identical yeast strains. Multivariate statistical analysis allowed us to discriminate between pair members based on their metabolic phenotypes. Our results highlight the variability of the metabolome that exists even for less complex model systems cultured under defined conditions. We also highlight the efficacy of metabolic profiling for defining these subtle metabolic alterations.

  1. Optical Fibre Pressure Sensors in Medical Applications

    Directory of Open Access Journals (Sweden)

    Sven Poeggel


    Full Text Available This article is focused on reviewing the current state-of-the-art of optical fibre pressure sensors for medical applications. Optical fibres have inherent advantages due to their small size, immunity to electromagnetic interferences and their suitability for remote monitoring and multiplexing. The small dimensions of optical fibre-based pressure sensors, together with being lightweight and flexible, mean that they are minimally invasive for many medical applications and, thus, particularly suited to in vivo measurement. This means that the sensor can be placed directly inside a patient, e.g., for urodynamic and cardiovascular assessment. This paper presents an overview of the recent developments in optical fibre-based pressure measurements with particular reference to these application areas.

  2. Government can regulate food advertising to children because cognitive research shows that it is inherently misleading. (United States)

    Graff, Samantha; Kunkel, Dale; Mermin, Seth E


    The childhood obesity crisis has prompted repeated calls for government action to curb the marketing of unhealthy food to children. Food and entertainment industry groups have asserted that the First Amendment prohibits such regulation. However, case law establishes that the First Amendment does not protect "inherently misleading" commercial speech. Cognitive research indicates that young children cannot effectively recognize the persuasive intent of advertising or apply the critical evaluation required to comprehend commercial messages. Given this combination--that government can prohibit "inherently misleading" advertising and that children cannot adequately understand commercial messages--advertising to children younger than age twelve should be considered beyond the scope of constitutional protection.

  3. Cardiovascular physiology and sleep. (United States)

    Murali, Narayana S; Svatikova, Anna; Somers, Virend K


    Sleep is a natural periodic suspension of consciousness during which processes of rest and restoration occur. The cognitive, reparative and regenerative accompaniments of sleep appear to be essential for maintenance of health and homeostasis. This brief overview will examine the cardiovascular responses to normal and disordered sleep, and their physiologic and pathologic implications. In the past, sleep was believed to be a passive state. The tableau of sleep as it unfolds is anything but a passive process. The brain's activity is as complex as wakefulness, never "resting" during sleep. Following the demise of the 'passive theory of sleep' (the reticular activating system is fatigued during the waking day and hence becomes inactive), there arose the 'active theory of sleep' (sleep is due to an active general inhibition of the brain) (1). Hess demonstrated the active nature of sleep in cats, inducing "physiological sleep" with electrical stimulation of the diencephalon (2). Classical experiments of transection of the cat brainstem (3) at midpontine level inhibited sleep completely, implying that centers below this level were involved in the induction of sleep (1, 4). For the first time, measurement of sleep depth without awakening the sleeper using the electroencephalogram (EEG) was demonstrated in animals by Caton and in humans, by Berger (1). This was soon followed by discovery of the rapid eye movement sleep periods (REM) by Aserinski and Kleitman (5), demonstration of periodical sleep cycles and their association with REM sleep (6, 7). Multiple studies and steady discoveries (4) made polysomnography, with its ability to perform simultaneous whole night recordings of EEG, electromyogram (EMG), and electrooculogram (EOC), a major diagnostic tool in study of sleep disorders. This facility has been of further critical importance in allowing evaluation of the interaction between sleep and changes in hemodynamics and autonomic cardiovascular control. Consequently the

  4. The use of echocardiography in acute cardiovascular care

    DEFF Research Database (Denmark)

    Lancellotti, Patrizio; Price, Susanna; Edvardsen, Thor


    of echocardiography in acute cardiovascular care. In this document, we describe the practical applications of echocardiography in patients with acute cardiac conditions, in particular with acute chest pain, acute heart failure, suspected cardiac tamponade, complications of myocardial infarction, acute valvular heart...... disease including endocarditis, acute disease of the ascending aorta and post-intervention complications. Specific issues regarding echocardiography in other acute cardiovascular care scenarios are also described....

  5. The use of echocardiography in acute cardiovascular care

    DEFF Research Database (Denmark)

    Lancellotti, Patrizio; Price, Susanna; Edvardsen, Thor


    of echocardiography in acute cardiovascular care. In this document, we describe the practical applications of echocardiography in patients with acute cardiac conditions, in particular with acute chest pain, acute heart failure, suspected cardiac tamponade, complications of myocardial infarction, acute valvular heart...... disease including endocarditis, acute disease of the ascending aorta and post-intervention complications. Specific issues regarding echocardiography in other acute cardiovascular care scenarios are also described....

  6. Osteoporosis y enfermedad cardiovascular


    Sarahí Mendoza; Miriam Noa; Rosa Más


    Las enfermedades cardiovasculares (ECV) y la osteoporosis son causas frecuentes de morbilidad en la población adulta, cuya frecuencia aumenta con la edad, por lo que al aumentar la expectativa de vida, constituyen importantes problemas de salud. El riesgo a padecer ambas patologías depende de factores de riesgo, y la prevención consiste en controlar los modificables. Las ECV y la osteoporosis presentan factores etiológicos comunes que involucran la biosíntesis del colesterol y la oxidación li...

  7. Postnatal Cardiovascular Adaptation

    Directory of Open Access Journals (Sweden)

    Ferda Ozlu


    Full Text Available Fetus depends on placental circulation in utero. A successful transition from intrauterin to extrauterine life depends on succesful physiological changes during labor. During delivery, fetus transfers from a liquid environment where oxygen comes via umbilical vein to air environement where oxygenation is supported via air breathing. Endocrinological changes are important for fetus to adapt to extrauterine life. In addition to these, cord clemping plays a crucial role in postnatal adaptation. Establishment of neonatal postnatal life and succesful overcome, the fetal cardiovascular transition period are important to stay on. [Archives Medical Review Journal 2016; 25(2.000: 181-190

  8. Cardiovascular hypertensive emergencies. (United States)

    Papadopoulos, D P; Sanidas, E A; Viniou, N A; Gennimata, V; Chantziara, V; Barbetseas, I; Makris, T K


    Inevitably, a small proportion of patients with systematic hypertension will develop hypertensive crisis at some point. Hypertensive crises can be divided into hypertensive emergency or hypertensive urgency according to the presence or lack of acute target organ damage. In this review, we discuss cardiovascular hypertensive emergencies, including acute coronary syndrome, aortic dissection, congestive heart failure, and sympathomimetic hypertensive crises, including those caused by cocaine use. Each presents in a unique fashion, although some hypertensive emergency patients report nonspecific symptoms. Treatment includes several effective and rapid-acting medications to safely reduce the blood pressure, protect remaining end-organ function, relieve symptoms, minimize the risk of complications, and thereby improve patient outcomes.

  9. Fetal cardiovascular physiology. (United States)

    Rychik, J


    The cardiovascular system of the fetus is physiologically different than the adult, mature system. Unique characteristics of the myocardium and specific channels of blood flow differentitate the physiology of the fetus from the newborn. Conditions of increased preload and afterload in the fetus, such as sacrococcygeal teratoma and twin-twin transfusion syndrome, result in unique and complex pathophysiological states. Echocardiography has improved our understanding of human fetal cadiovasvular physiology in the normal and diseased states, and has expanded our capability to more effectively treat these disease processes.

  10. Antioxidantes y enfermedad cardiovascular


    Vázquez, Clotilde


    La enfermedad cardiovascular se mantiene como la más importante causa de morbi y mortalidad en la mayoría de los países desarrollados, siendo cada vez más frecuente en los países en vías de desarrollo. La orteroesclerosis es un enfermedad crónica de las arterias de mediano y gran calibre, caracterizadas por el endurecimiento y pérdida de elasticidad de su pared, que se acompaña de estrechamiento de su luz. En general, la lesión arteriosclerótica se desarrolla en tres fases: a) inici...

  11. Pharmacogenetics of cardiovascular drug therapy


    Peters, Bas J.M.; Olaf H Klungel; de Boer, Anthonius; Ch Stricker, Bruno H; Maitland-van der Zee, Anke-Hilse


    In developed countries cardiovascular disease is one of the leading causes of death. Cardiovascular drugs such as platelet aggregation inhibitors, oral anticoagulants, antihypertensives and cholesterol lowering drugs are abundantly prescribed to reduce risk of cardiovascular disease. Notable interindividual variation exists in the response to these pharmacotherapeutic interventions, which can be partially explained by factors such as gender, age, diet, concomitant drug use and environmental f...

  12. Oxidative Stress in Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Gábor Csányi


    Full Text Available In the special issue “Oxidative Stress in Cardiovascular Disease” authors were invited to submit papers that investigate key questions in the field of cardiovascular free radical biology. The original research articles included in this issue provide important information regarding novel aspects of reactive oxygen species (ROS-mediated signaling, which have important implications in physiological and pathophysiological cardiovascular processes. The issue also included a number of review articles that highlight areas of intense research in the fields of free radical biology and cardiovascular medicine.

  13. 16 CFR 1211.13 - Inherent force activated secondary door sensors. (United States)


    ... sensors. 1211.13 Section 1211.13 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT... § 1211.13 Inherent force activated secondary door sensors. (a) Normal operation test. (1) A force activated door sensor of a door system installed according to the installation instructions shall...

  14. The inherence heuristic: a key theoretical addition to understanding social stereotyping and prejudice. (United States)

    Bigler, Rebecca S; Clark, Caitlin


    Prior work has detailed the constructivist processes that lead individuals to categorize others along particular dimensions (e.g., gender) and generate the content (e.g., stereotypes) and affect (e.g., prejudices) associated with social groups. The inherence heuristic is a novel mechanism that appears to shape the content and rigidity of children's social stereotypes and prejudices.

  15. Incorporating Risk Assessment and Inherently Safer Design Practices into Chemical Engineering Education (United States)

    Seay, Jeffrey R.; Eden, Mario R.


    This paper introduces, via case study example, the benefit of including risk assessment methodology and inherently safer design practices into the curriculum for chemical engineering students. This work illustrates how these tools can be applied during the earliest stages of conceptual process design. The impacts of decisions made during…

  16. Experimental evidence for inherent Lévy search behaviour in foraging animals

    NARCIS (Netherlands)

    Kölzsch, A.; Alzate, A.; Bartumeus, F.; de Jager, M.; Weerman, E.; Hengeveld, G.M.; Naguib, M.; Nolet, B.A.; Van de Koppel, J.


    Recently, Lévy walks have been put forward as a new paradigm for animal search and many cases have been made for its presence in nature. However, it remains debated whether Lévy walks are an inherent behavioural strategy or emerge from the animal reacting to its habitat. Here, we demonstrate signatu

  17. Child as Totem: Redressing the Myth of Inherent Creativity in Early Childhood (United States)

    McClure, Marissa


    In this article, I present a reexamination of the myth of inherent creativity in early childhood to elucidate how still-dominant discourses of optimization such as child development, individualism, expression, creativity, and visual realism exert limiting pressures on understandings of the art and visual culture that children consume and create.…

  18. An Inherent Chiral Calix[4]arene Bearing Chiral Groups without Forming Sub-ring

    Institute of Scientific and Technical Information of China (English)

    Xian Xian LIU; Yan Song ZHENG; Wan Ling MO


    The NMR spectra revealed that the calixarene frame of 1, 3-disubstituted calix[4]arenes bearing optically active groups is asymmetric, even without the formation of a sub-ring. This inherent chirality arises from the interaction of the two chiral groups, which hinder the substituents' free rotation. Thus, these chiral calix[4]arenes display good chiral recognition ability.

  19. Making the Grade: Describing Inherent Requirements for the Initial Teacher Education Practicum (United States)

    Sharplin, Elaine; Peden, Sanna; Marais, Ida


    This study explores the development, description, and illustration of inherent requirement (IR) statements to make explicit the requirements for performance on an initial teacher education (ITE) practicum. Through consultative group processes with stakeholders involved in ITE, seven IR domains were identified. From interviews with academics,…

  20. The Inherent Politics of Managing the Quality of Urban Green Spaces

    DEFF Research Database (Denmark)

    Lindholst, Andrej Christian; Sullivan, Sidney George; Konijnendijk, Cecil Cornelis;


    of such ‘inherent politics’ through a case study of a widespread approach to operationalizing quality in urban green space management. We conclude that adoption of any quality model has both limiting and enabling implications for public participation and decision-making and that a critical stance is needed within...

  1. The attractive Achilles heel of germ cell tumours : an inherent sensitivity to apoptosis-inducing stimuli

    NARCIS (Netherlands)

    Spierings, DCJ; de Vries, EGE; Vellenga, E; de Jong, S


    Testicular germ cell tumours (TGCTs) are extremely sensitive to cisplatin-containing chemotherapy. The rapid time course of apoptosis induction after exposure to cisplatin suggests that TGCT cells are primed to undergo programmed cell death as an inherent property of the cell of origin. In fact, apo

  2. Inherent and apparent optical measurements in the Hudson/Raritan estuary

    NARCIS (Netherlands)

    Bagheri, S.; Rijkeboer, M.; Gons, H.J.


    During an August, 1999 field campaign, measurements were made to establish hydrologic optical properties of the Hudson/Raritan Estuary (New York-New Jersey): 1) concurrent above-and below-surface spectral irradiance; 2) sampling for laboratory determination of inherent optical properties; and 3) con

  3. The Market for Academic Knowledge: Its Historical Emergence and Inherent Tensions (United States)

    Weik, Elke


    This paper contributes to the discussion about the marketisation of universities by providing a historical perspective. Going back to the time when the market for academic knowledge emerged, I argue that it was created through incorporating a number of inherent tensions that have been, and still are, shaping its development. I show how these…

  4. [The concentration of growth factors in patients with inherent and acquired shortenings of limbs bones]. (United States)

    Strogov, M V; Luneva, S N; Novikov, K I


    The article deals with the results of study of level of growth factors in blood serum of patients with inherent and post-traumatic shortenings of limbs' bones. The detection in blood serum the level of epidermal growth factor insulin-like growth factor I and angiopoetins is proposed to monitor in given patients the reparative bone formation.

  5. Unlocking variability: inherent variation and developmental traits of garlic plants originated from sexual reproduction

    NARCIS (Netherlands)

    Shemesh, E.; Scholten, O.E.; Rabinowitch, H.D.; Kamenetsky, R.


    Recent collections of fertile garlic (Allium sativum) accessions from Central Asia allow a detailed study of seedling developments and the evaluation of inherent variations. We hereby provide a comprehensive account of the ontogenesis of a population of garlic seedlings and their vegetative and repr

  6. Cardiovascular benefits of exercise

    Directory of Open Access Journals (Sweden)

    Agarwal SK


    Full Text Available Shashi K AgarwalMedical Director, Agarwal Health Center, NJ, USAAbstract: Regular physical activity during leisure time has been shown to be associated with better health outcomes. The American Heart Association, the Centers for Disease Control and Prevention and the American College of Sports Medicine all recommend regular physical activity of moderate intensity for the prevention and complementary treatment of several diseases. The therapeutic role of exercise in maintaining good health and treating diseases is not new. The benefits of physical activity date back to Susruta, a 600 BC physician in India, who prescribed exercise to patients. Hippocrates (460–377 BC wrote “in order to remain healthy, the entire day should be devoted exclusively to ways and means of increasing one's strength and staying healthy, and the best way to do so is through physical exercise.” Plato (427–347 BC referred to medicine as a sister art to physical exercise while the noted ancient Greek physician Galen (129–217 AD penned several essays on aerobic fitness and strengthening muscles. This article briefly reviews the beneficial effects of physical activity on cardiovascular diseases.Keywords: exercise, cardiovascular disease, lifestyle changes, physical activity, good health

  7. Resveratrol and Cardiovascular Diseases

    Directory of Open Access Journals (Sweden)

    Dominique Bonnefont-Rousselot


    Full Text Available The increased incidence of cardiovascular diseases (CVDs has stimulated research for substances that could improve cardiovascular health. Among them, resveratrol (RES, a polyphenolic compound notably present in grapes and red wine, has been involved in the “French paradox”. RES is known for its antioxidant and anti-inflammatory properties and for its ability to upregulate endothelial NO synthase (eNOS. RES was able to scavenge •OH/O2•− and peroxyl radicals, which can limit the lipid peroxidation processes. Moreover, in bovine aortic endothelial cells (BAEC under glucose-induced oxidative stress, RES restored the activity of dimethylargininedimethylaminohydrolase (DDAH, an enzyme that degrades an endogenous inhibitor of eNOS named asymmetric dimethylarginine (ADMA. Thus, RES could improve •NO availability and decrease the endothelial dysfunction observed in diabetes. Preclinical studies have made it possible to identify molecular targets (SIRT-1, AMPK, Nrf2, NFκB…; however, there are limited human clinical trials, and difficulties in the interpretation of results arise from the use of high-dose RES supplements in research studies, whereas low RES concentrations are present in red wine. The discussions on potential beneficial effects of RES in CVDs (atherosclerosis, hypertension, stroke, myocardial infarction, heart failure should compare the results of preclinical studies with those of clinical trials.

  8. Cardiovascular Complications of Pregnancy

    Directory of Open Access Journals (Sweden)

    Maria Carolina Gongora


    Full Text Available Pregnancy causes significant metabolic and hemodynamic changes in a woman’s physiology to allow for fetal growth. The inability to adapt to these changes might result in the development of hypertensive disorders of pregnancy (hypertension, preeclampsia or eclampsia, gestational diabetes and preterm birth. Contrary to previous beliefs these complications are not limited to the pregnancy period and may leave permanent vascular and metabolic damage. There is in addition, a direct association between these disorders and increased risk of future cardiovascular disease (CVD, including hypertension, ischemic heart disease, heart failure and stroke and diabetes mellitus. Despite abundant evidence of this association, women who present with these complications of pregnancy do not receive adequate postpartum follow up and counseling regarding their increased risk of future CVD. The postpartum period in these women represents a unique opportunity to intervene with lifestyle modifications designed to reduce the development of premature cardiovascular complications. In some cases it allows early diagnosis and treatment of chronic hypertension or diabetes mellitus. The awareness of this relationship is growing in the medical community, especially among obstetricians and primary care physicians, who play a pivotal role in detecting these complications and assuring appropriate follow up.

  9. Cardiovascular Complications of Pregnancy. (United States)

    Gongora, Maria Carolina; Wenger, Nanette K


    Pregnancy causes significant metabolic and hemodynamic changes in a woman's physiology to allow for fetal growth. The inability to adapt to these changes might result in the development of hypertensive disorders of pregnancy (hypertension, preeclampsia or eclampsia), gestational diabetes and preterm birth. Contrary to previous beliefs these complications are not limited to the pregnancy period and may leave permanent vascular and metabolic damage. There is in addition, a direct association between these disorders and increased risk of future cardiovascular disease (CVD, including hypertension, ischemic heart disease, heart failure and stroke) and diabetes mellitus. Despite abundant evidence of this association, women who present with these complications of pregnancy do not receive adequate postpartum follow up and counseling regarding their increased risk of future CVD. The postpartum period in these women represents a unique opportunity to intervene with lifestyle modifications designed to reduce the development of premature cardiovascular complications. In some cases it allows early diagnosis and treatment of chronic hypertension or diabetes mellitus. The awareness of this relationship is growing in the medical community, especially among obstetricians and primary care physicians, who play a pivotal role in detecting these complications and assuring appropriate follow up.

  10. Aplicação da ventilação não-invasiva em insuficiência respiratória aguda após cirurgia cardiovascular Application of noninvasive ventilation in acute respiratory failure after cardiovascular surgery

    Directory of Open Access Journals (Sweden)

    Vera Regina de Morais Coimbra


    response, oxygenation-related, and hemodynamics of patients with hypoxemic acute respiratory failure (ARF submitted to noninvasive mechanical ventilation (NIV during the postoperative phase of cardiovascular surgery in order to identify predictive variables of success, and to compare the different types of NIV. METHODS: Seventy patients with hypoxemic ARF were randomized to one of three modalities of NIV - continuous positive airway pressure (CPAP and ventilation with two pressure levels (PEEP + SP and BiPAP®. Ventilation, oxygenation-related, and hemodynamics variables were analyzed at pre-application, and 3, 6, and 12 hours after the protocol began. RESULTS: Thirteen patients were excluded. Thirty-one patients progressed to independence from ventilatory support and comprised the success group, and 26 required orotracheal intubation and were considered the nonsuccess group. Age, initial heart rate (HR, and respiratory rate (RR showed elevated levels in the nonsuccess group (p=0.042, 0.029, and 0.002, respectively. A greater number of intraoperative complications were seen in the nonsuccess group (p=0.025. Oxygenation variables increased only in the success group. Among the NIV types, 57.9% of patients in the ventilator group, 57.9% in the two-pressure levels group, and 47.3% in the CPAP group progressed with success. Oxygenation and RR variables showed improvement only in the groups with two pressure levels. CONCLUSION: Patients with hypoxemic ARF in the postoperative stage after cardiovascular surgery showed better oxygenation, RR, and HR during NIV application. In older patients and those with higher baseline RR and HR values, NIV was not sufficient to reverse ARF. The two-pressure level modes showed better results.

  11. Location estimation of approaching objects is modulated by the observer's inherent and momentary action capabilities. (United States)

    Kandula, Manasa; Hofman, Dennis; Dijkerman, H Chris


    Action capability may be one of the factors that can influence our percept of the world. A distinction can be made between momentary action capability (action capability at that particular moment) and inherent action capability (representing a stable action capability). In the current study, we investigated whether there was a biasing effect of these two forms of action capability on visual perception of location. In a virtual reality room, subjects had to stop a moving ball from hitting a pillar. On some trials, the ball disappeared automatically during its motion. Subjects had to estimate the location of the ball's disappearance in these trials. We expected that if action is necessary but action capability (inherent or momentary) is limiting performance, the location of approaching objects with respect to the observer is underestimated. By judging the objects to be nearer than they really are, the need to select and execute the appropriate action increases, thereby facilitating quick action (Cole et al. in Psychol Sci 24(1):34-40, 2013. doi: 10.1177/0956797612446953 ). As a manipulation of inherent action capability in a virtual environment, two groups of participants (video game players vs. non-video game players) were entered into the study (high and low action capability). Momentary action capability was manipulated by using two difficulty levels in the experiment (Easy vs. Difficult). Results indicated that inherent and momentary action capabilities interacted together to influence online location judgments: Non-players underestimated locations when the task was Difficult. Taken together, our data suggest that both inherent and momentary action capabilities influence location judgments.

  12. Tracer application in cardiovascular imaging: a Triple Jump, Chapter 7 : In: Autonomic Innervation of the Heart, Edited by R.H.J.A. Slart, R.A. Tio, P.H. Elsinga and M. Schwaiger

    NARCIS (Netherlands)

    de Roo, F. Michelle; Hilgerink, Koen; Kosterink, Johannes; Luurtsema, Geert; Woerdenbag, Herman; Boersma, Hendrikus; Slart, Riemer; Tio, Rene; Elsinga, Philipus; Schwaiger, Markus


    Next to aspects related to the imaging techniques, the quality of the used cardiovascular tracer is of major importance to produce reliable images, leading to accurate diagnoses as well as outcome of research and imaging-correlated treatment. We have built up this chapter on cardiovascular imaging a

  13. Cardiovascular magnetic resonance in carotid atherosclerotic disease

    Directory of Open Access Journals (Sweden)

    Chen Huijun


    Full Text Available Abstract Atherosclerosis is a chronic, progressive, inflammatory disease affecting many vascular beds. Disease progression leads to acute cardiovascular events such as myocardial infarction, stroke and death. The diseased carotid alone is responsible for one third of the 700,000 new or recurrent strokes occurring yearly in the United States. Imaging plays an important role in the management of atherosclerosis, and cardiovascular magnetic resonance (CMR of the carotid vessel wall is one promising modality in the evaluation of patients with carotid atherosclerotic disease. Advances in carotid vessel wall CMR allow comprehensive assessment of morphology inside the wall, contributing substantial disease-specific information beyond luminal stenosis. Although carotid vessel wall CMR has not been widely used to screen for carotid atherosclerotic disease, many trials support its potential for this indication. This review summarizes the current state of knowledge regarding carotid vessel wall CMR and its potential clinical application for management of carotid atherosclerotic disease.

  14. Cheese and cardiovascular disease risk

    DEFF Research Database (Denmark)

    Hjerpsted, Julie Bousgaard; Tholstrup, Tine


    Abstract Currently, the effect of dairy products on cardiovascular risk is a topic with much debate and conflicting results. The purpose of this review is to give an overview of the existing literature regarding the effect of cheese intake and risk of cardiovascular disease (CVD). Studies included...

  15. Indian poverty and cardiovascular disease. (United States)

    Ramaraj, Radhakrishnan; Alpert, Joseph Stephen


    Cardiovascular disease is among the world's leading causes of death, and nearly 80% of deaths occur in developing countries. Cardiovascular disease is becoming a major health problem in India, where life expectancy has increased with decreases in infectious disease and childhood mortality. It is well established that this population experiences coronary artery disease at a younger age than other populations. With infectious diseases still endemic, noncommunicable diseases are a lower priority for the governments of developing countries. There is a clear progression to degenerative and lifestyle-related diseases such as cardiovascular disease as a result of current social and economic change. The lack of a public response to the increasing risk for cardiovascular disease thus far is due mostly to a perception among policy makers and the public that cardiovascular disease is largely a problem of the urban rich. In conclusion, this review addresses the imminent threats and ways to tackle the epidemic in India.

  16. Assessment of cardiovascular risk.

    LENUS (Irish Health Repository)

    Cooney, Marie Therese


    Atherosclerotic cardiovascular disease (CVD) is the most common cause of death worldwide. Usually atherosclerosis is caused by the combined effects of multiple risk factors. For this reason, most guidelines on the prevention of CVD stress the assessment of total CVD risk. The most intensive risk factor modification can then be directed towards the individuals who will derive the greatest benefit. To assist the clinician in calculating the effects of these multiple interacting risk factors, a number of risk estimation systems have been developed. This review address several issues regarding total CVD risk assessment: Why should total CVD risk be assessed? What risk estimation systems are available? How well do these systems estimate risk? What are the advantages and disadvantages of the current systems? What are the current limitations of risk estimation systems and how can they be resolved? What new developments have occurred in CVD risk estimation?

  17. Cardiovascular complications in acromegaly. (United States)

    Vitale, G; Pivonello, R; Lombardi, G; Colao, A


    Cardiovascular morbidity and mortality are increased in acromegaly. In fact, GH and IGF-I excess induces a specific cardiomyopathy. The early stage of acromegaly is characterized by the hyperkinetic syndrome (high heart rate and increased systolic output). Frequently, concentric biventricular hypertrophy and diastolic dysfunction occur in acromegaly, leading to an impaired systolic function ending in heart failure if the disease is untreated or unsuccessfully untreated. Besides, abnormalities of cardiac rhythm and of valves have been also described in acromegaly. The coexistence of other complications, such as arterial hypertension and diabetes, aggravates the acromegalic cardiomyopathy. The suppression of GH/IGF-I following an efficacious therapy could decrease left ventricular mass and improve cardiac function. In conclusion, a careful evaluation of cardiac function, morphology and activity seems to be mandatory in acromegaly.

  18. Cardiovascular diseases and diabetes

    DEFF Research Database (Denmark)

    Green, A.; Sortso, C.; Jensen, Peter Bjødstrup


    We present an investigation of the occurrence of cardiovascular disease in patients with diabetes in Denmark 2000 through 2011. The Diabetes Impact Study 2013 is based on all registrants in the Danish National Diabetes Register as of July 3rd 2013 (n=497,232). Record linkage with the Danish...... of diabetes has been rather constant at higher level in males (around 16-18%) than in females (around 12-14%) during 2000-2011 (incl.). In contrast, the incidence rate of CVD after having diabetes diagnosis has declined from about 4.5 to less than 3 during the same period, with higher declining level...... for males than for females. Efforts to detect diabetes at an earlier stage have not resulted in a reduced occurrence of CVD at the diagnosis of diabetes in Denmark. However, the risk of developing CVD after the diagnosis of diabetes has been declining, possibly reflecting benefits of intensified treatment...

  19. Discrete element modeling of inherently anisotropic granular assemblies with polygonal particles

    Institute of Scientific and Technical Information of China (English)

    Ehsan Seyedi Hosseininia


    In the present article,we study the effect of inherent anisotropy,i.e.,initial bedding angle of particles and associated voids on macroscopic mechanical behavior of granular materials,by numerical simulation of several biaxial compression tests using the discrete element method (DEM).Particle shape is considered to be irregular convex-polygonal.The effect of inherent anisotropy is investigated by following the evolution of mobilized shear strength and volume change during loading.As experimental tests have already shown,numerical simulations also indicate that initial anisotropic condition has a great influence on the strength and deformational behavior of granular assemblies.Comparison of simulations with tests using oval particles,shows that angularity influences both the mobilized shear strength and the volume change regime,which originates from the interlocking resistance between particles.

  20. Maximum acceptable inherent buoyancy limit for aircrew/passenger helicopter immersion suit systems. (United States)

    Brooks, C J


    Helicopter crew and passengers flying over cold water wear immersion suits to provide hypothermic protection in case of ditching in cold water. The suits and linings have trapped air in the material to provide the necessary insulation and are thus very buoyant. By paradox, this buoyancy may be too much for a survivor to overcome in escaping from the cabin of a rapidly sinking inverted helicopter. The Canadian General Standard Board requested that research be conducted to investigate what should be the maximum inherent buoyancy in an immersion suit that would not inhibit escape, yet would provide adequate thermal insulation. This experiment reports on 12 subjects who safely escaped with 146N (33 lbf) of added buoyancy from a helicopter underwater escape trainer. It discusses the logic for and recommendation that the inherent buoyancy in a helicopter crew/passenger immersion suit system should not exceed this figure.

  1. Evaluation of an intensified continuous heat-exchanger reactor for inherently safer characteristics


    BENAISSA, Wassila; Gabas, Nadine; Cabassud, Michel; Carson, Douglas; Elgue, Sébastien; Demissy, Michel


    The present paper deals with the establishment of a new methodology in order to evaluate the inherently safer characteristics of a continuous intensified reactor in the case of an exothermic reaction. The transposition of the propionic anhydride esterification by 2-butanol into a new prototype of ‘‘heatexchanger/ reactor’’, called open plate reactor (OPR), designed by Alfa Laval Vicarb has been chosen as a case study. Previous studies have shown that this exothermic reaction is relatively sim...

  2. Ethical problems inherent in psychological research based on internet communication as stored information

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter; Dyhrberg, Johan


    This paper deals with certain ethical problems inherent in psychological research based on internet communication as stored information. Section 1 contains an analysis of research on Internet debates. In particular, it takes into account a famous example of deception for psychology research...... purposes. In section 2, the focus is on research on personal data in texts published on the Internet. Section 3 includes an attempt to formulate some ethical principles and guidelines, which should be regarded as fundamental in research on stored information....

  3. Brain activation patterns at exhaustion in rats that differ in inherent exercise capacity.

    Directory of Open Access Journals (Sweden)

    Teresa E Foley

    Full Text Available In order to further understand the genetic basis for variation in inherent (untrained exercise capacity, we examined the brains of 32 male rats selectively bred for high or low running capacity (HCR and LCR, respectively. The aim was to characterize the activation patterns of brain regions potentially involved in differences in inherent running capacity between HCR and LCR. Using quantitative in situ hybridization techniques, we measured messenger ribonuclease (mRNA levels of c-Fos, a marker of neuronal activation, in the brains of HCR and LCR rats after a single bout of acute treadmill running (7.5-15 minutes, 15° slope, 10 m/min or after treadmill running to exhaustion (15-51 minutes, 15° slope, initial velocity 10 m/min. During verification of trait differences, HCR rats ran six times farther and three times longer prior to exhaustion than LCR rats. Running to exhaustion significantly increased c-Fos mRNA activation of several brain areas in HCR, but LCR failed to show significant elevations of c-Fos mRNA at exhaustion in the majority of areas examined compared to acutely run controls. Results from these studies suggest that there are differences in central c-Fos mRNA expression, and potential brain activation patterns, between HCR and LCR rats during treadmill running to exhaustion and these differences could be involved in the variation in inherent running capacity between lines.

  4. Disease resistance is related to inherent swimming performance in Atlantic salmon

    Directory of Open Access Journals (Sweden)

    Castro Vicente


    Full Text Available Abstract Background Like humans, fish can be classified according to their athletic performance. Sustained exercise training of fish can improve growth and physical capacity, and recent results have documented improved disease resistance in exercised Atlantic salmon. In this study we investigated the effects of inherent swimming performance and exercise training on disease resistance in Atlantic salmon. Atlantic salmon were first classified as either poor or good according to their swimming performance in a screening test and then exercise trained for 10 weeks using one of two constant-velocity or two interval-velocity training regimes for comparison against control trained fish (low speed continuously. Disease resistance was assessed by a viral disease challenge test (infectious pancreatic necrosis and gene expression analyses of the host response in selected organs. Results An inherently good swimming performance was associated with improved disease resistance, as good swimmers showed significantly better survival compared to poor swimmers in the viral challenge test. Differences in mortalities between poor and good swimmers were correlated with cardiac mRNA expression of virus responsive genes reflecting the infection status. Although not significant, fish trained at constant-velocity showed a trend towards higher survival than fish trained at either short or long intervals. Finally, only constant training at high intensity had a significant positive effect on fish growth compared to control trained fish. Conclusions This is the first evidence suggesting that inherent swimming performance is associated with disease resistance in fish.

  5. Impact of exotic and inherent dissolved organic matter on sorption of phenanthrene by soils. (United States)

    Gao, Yanzheng; Xiong, Wei; Ling, Wanting; Wang, Xiaorong; Li, Qiuling


    The impacts of exotic and inherent dissolved organic matter (DOM) on phenanthrene sorption by six zonal soils of China, chosen so as to have different soil organic carbon (SOC) contents, were investigated using a batch technique. The exotic DOM was extracted from straw waste. In all cases, the sorption of phenanthrene by soils could be well described by the linear equation. The presence of inherent DOM in soils was found to impede phenanthrene sorption, since the apparent distribution coefficients (K(d)(*)) for phenanthrene sorption by deionized water-eluted soils were 3.13-21.5% larger than the distribution coefficients (K(d)) by control soils. Moreover, the enhanced sorption of phenanthrene by eluted versus control soils was in positive correlation with SOC contents. On the other hand, it was observed that the influence of exotic DOM on phenanthrene sorption was related to DOM concentrations. The K(d)(*) values for sorption of phenanthrene in the presence of exotic DOM increased first and decreased thereafter with increasing the added DOM concentrations (0-106mgDOC/L). The K(d)(*) values at a low exotic DOM concentration ( or =52mgDOC/L) of added exotic DOM clearly impeded the distribution of phenanthrene between soil and water. The effects of exotic and inherent DOM on phenanthrene sorption by soils may primarily be described as 'cumulative sorption', association of phenanthene with DOM in solution, and modified surface nature of soil solids due to DOM binding.

  6. Nature of Communication Ineffectiveness Inherent in the Procurement Systems on Mass Housing Projects

    Directory of Open Access Journals (Sweden)

    Titus Ebenezer Kwofie


    Full Text Available Mass housing projects (MHPs are deemed to exhibit unique procurement systems which consequently induce communication ineffectiveness that continues to dominate the challenges among mass housing project teams. However, this acknowledged communication ineffectiveness inherent in the unique procurement system features of mass housing project among the project team remains to be empirically examined. This study seeks to investigate the influence of procurement system (PS features of MHPs to communication ineffectiveness among the mass housing project team. By adopting a quantitative method design, a structured questionnaire survey on project team leaders managing MHPs in Ghana was used in collecting empirical data. Structural equation modeling (SEM was used to explore the communication problems inherent in the PS features of mass housing projects. The results revealed moderate to high effects of communication ineffectiveness in information flow and information composition inherent in the unique PS features of MHPs. The results further revealed misunderstanding, inaccuracies, barriers, and information dissemination challenges as the major communication ineffectiveness induced by the PS features of MHPs. By gaining knowledge and understanding into the communication ineffectiveness associated with these features of MHPs, practitioners are well positioned to plan communication and management strategies to engender success in mass housing delivery.

  7. Nrf2 and cardiovascular defense. (United States)

    Howden, Reuben


    The cardiovascular system is susceptible to a group of diseases that are responsible for a larger proportion of morbidity and mortality than any other disease. Many cardiovascular diseases are associated with a failure of defenses against oxidative stress-induced cellular damage and/or death, leading to organ dysfunction. The pleiotropic transcription factor, nuclear factor-erythroid (NF-E) 2-related factor 2 (Nrf2), regulates the expression of antioxidant enzymes and proteins through the antioxidant response element. Nrf2 is an important component in antioxidant defenses in cardiovascular diseases such as atherosclerosis, hypertension, and heart failure. Nrf2 is also involved in protection against oxidant stress during the processes of ischemia-reperfusion injury and aging. However, evidence suggests that Nrf2 activity does not always lead to a positive outcome and may accelerate the pathogenesis of some cardiovascular diseases (e.g., atherosclerosis). The precise conditions under which Nrf2 acts to attenuate or stimulate cardiovascular disease processes are unclear. Further studies on the cellular environments related to cardiovascular diseases that influence Nrf2 pathways are required before Nrf2 can be considered a therapeutic target for the treatment of cardiovascular diseases.

  8. Nrf2 and Cardiovascular Defense

    Directory of Open Access Journals (Sweden)

    Reuben Howden


    Full Text Available The cardiovascular system is susceptible to a group of diseases that are responsible for a larger proportion of morbidity and mortality than any other disease. Many cardiovascular diseases are associated with a failure of defenses against oxidative stress-induced cellular damage and/or death, leading to organ dysfunction. The pleiotropic transcription factor, nuclear factor-erythroid (NF-E 2-related factor 2 (Nrf2, regulates the expression of antioxidant enzymes and proteins through the antioxidant response element. Nrf2 is an important component in antioxidant defenses in cardiovascular diseases such as atherosclerosis, hypertension, and heart failure. Nrf2 is also involved in protection against oxidant stress during the processes of ischemia-reperfusion injury and aging. However, evidence suggests that Nrf2 activity does not always lead to a positive outcome and may accelerate the pathogenesis of some cardiovascular diseases (e.g., atherosclerosis. The precise conditions under which Nrf2 acts to attenuate or stimulate cardiovascular disease processes are unclear. Further studies on the cellular environments related to cardiovascular diseases that influence Nrf2 pathways are required before Nrf2 can be considered a therapeutic target for the treatment of cardiovascular diseases.

  9. Urotensin II in cardiovascular regulation

    Directory of Open Access Journals (Sweden)

    Fraser D Russell


    Full Text Available Fraser D RussellSchool of Health and Sport Sciences, Faculty of Science, Health and Education, University of the Sunshine Coast, Sippy Downs, Queensland, AustraliaAbstract: Cardiovascular function is modulated by neuronal transmitters, circulating hormones, and factors that are released locally from tissues. Urotensin II (UII is an 11 amino acid peptide that stimulates its’ obligatory G protein coupled urotensin II receptors (UT to modulate cardiovascular function in humans and in other animal species, and has been implicated in both vasculoprotective and vasculopathic effects. For example, tissue and circulating concentrations of UII have been reported to increase in some studies involving patients with atherosclerosis, heart failure, hypertension, preeclampsia, diabetes, renal disease and liver disease, raising the possibility that the UT receptor system is involved in the development and/or progression of these conditions. Consistent with this hypothesis, administration of UT receptor antagonists to animal models of cardiovascular disease have revealed improvements in cardiovascular remodelling and hemodynamics. However, recent studies have questioned this contributory role of UII in disease, and have instead postulated a protective effect on the cardiovascular system. For example, high concentrations of circulating UII correlated with improved clinical outcomes in patients with renal disease or myocardial infarction. The purpose of this review is to consider the regulation of the cardiovascular system by UII, giving consideration to methodologies for measurement of plasma concentrations, sites of synthesis and triggers for release.Keywords: urotensin II, cardiovascular disease, heart failure, hypertension

  10. Carbon dioxide balneotherapy and cardiovascular disease (United States)

    Pagourelias, Efstathios D.; Zorou, Paraskevi G.; Tsaligopoulos, Miltiadis; Athyros, Vasilis G.; Karagiannis, Asterios; Efthimiadis, Georgios K.


    Carbon dioxide (CO2) balneotherapy is a kind of remedy with a wide spectrum of applications which have been used since the Middle Ages. However, its potential use as an adjuvant therapeutic option in patients with cardiovascular disease is not yet fully clarified. We performed a thorough review of MEDLINE Database, EMBASE, ISI WEB of Knowledge, COCHRANE database and sites funded by balneotherapy centers across Europe in order to recognize relevant studies and aggregate evidence supporting the use of CO2 baths in various cardiovascular diseases. The three main effects of CO2 hydrotherapy during whole body or partial immersion, including decline in core temperature, an increase in cutaneous blood flow, and an elevation of the score on thermal sensation, are analyzed on a pathophysiology basis. Additionally, the indications and contra-indications of the method are presented in an evidence-based way, while the need for new methodologically sufficient studies examining the use of CO2 baths in other cardiovascular substrates is discussed.

  11. Effect of different processings on mechanical property and corrosion behavior in simulated body fluid of Mg-Zn-Y-Nd alloy for cardiovascular stent application (United States)

    Zhu, Shi-Jie; Liu, Qian; Qian, Ya-Feng; Sun, Bin; Wang, Li-Guo; Wu, Jing-Min; Guan, Shao-Kang


    The biomagnesium alloys have been considered to be one of the most potential biodegradable metal materials due to its good mechanical compatibility, biological compatibility, biological security and biodegradable characteristics. However, the two major problems of high degradation rates in physiological environment and low mechanical properties prevent the development of biomagnesium alloys. In the present work, the samples of Mg-Zn-Y-Nd alloy were prepared by cyclic extrusion compression (CEC) and equal channel angular pressing (ECAP). The microstructures, mechanical properties of alloy and its corrosion behavior in simulated body fluid (SBF) were evaluated. The results reveal that Mg-Zn-Y-Nd alloy consists of equiaxial fine grain structure with the homogeneous distribution of micrometer size and nano-sized second phase, which was caused by the dynamic recrystallization during the ECAP and CEC. The corrosion resistance of alloy was improved. The tensile and corrosion resistance were improved, especially the processed alloy exhibit uniform corrosion performances and decreased corrosion rate. This will provide theoretical ground for Mg-Zn-Y-Nd alloy as vascular stent application.

  12. Incorporation of a lauric acid-conjugated GRGDS peptide directly into the matrix of a poly(carbonate-urea)urethane polymer for use in cardiovascular bypass graft applications. (United States)

    Kidane, Asmeret G; Punshon, Geoffrey; Salacinski, Henryk J; Ramesh, Bala; Dooley, Audrey; Olbrich, Michael; Heitz, Johannes; Hamilton, George; Seifalian, Alexander M


    Gly-Arg-Gly-Asp-Ser (GRGDS) was modified by conjugation to lauric acid (LA) to facilitate incorporation into the matrix of a poly(carbonate-urea)urethane (PCU) used in vascular bypass grafts. GRGDS and LA-GRGDS were synthesized using solid phase Fmoc chemistry and characterized by high performance liquid chromatography and Fourier transform infrared spectroscopy. LA-GRGDS was passively coated and incorporated as nanoparticle dispersion on the PCU films. Biocompatibility of the modified surfaces was investigated. Endothelial cells seeded on LA-GRGDS coated and incorporated PCU showed after 48 h and 72 h a significant (p < 0.05) increase in metabolism compared with unmodified PCU. The platelet adhesion and hemolysis studies showed that the modification of PCU had no adverse effect. In conclusion, LA-conjugated RGD derivatives, such as LA-GRGDS, that permit solubility into solvents used in solvent casting methodologies should have wide applicability in polymer development for use in coronary, vascular, and dialysis bypass grafts, and furthermore scaffolds utilized for tissue regeneration and tissue engineering.

  13. Undergraduates' understanding of cardiovascular phenomena. (United States)

    Michael, Joel A; Wenderoth, Mary Pat; Modell, Harold I; Cliff, William; Horwitz, Barbara; McHale, Philip; Richardson, Daniel; Silverthorn, Dee; Williams, Stephen; Whitescarver, Shirley


    Undergraduates students in 12 courses at 8 different institutions were surveyed to determine the prevalence of 13 different misconceptions (conceptual difficulties) about cardiovascular function. The prevalence of these misconceptions ranged from 20 to 81% and, for each misconception, was consistent across the different student populations. We also obtained explanations for the students' answers either as free responses or with follow-up multiple-choice questions. These results suggest that students have a number of underlying conceptual difficulties about cardiovascular phenomena. One possible source of some misconceptions is the students' inability to apply simple general models to specific cardiovascular phenomena. Some implications of these results for teachers of physiology are discussed.

  14. Fish cardiovascular physiology and disease. (United States)

    Sherrill, Johanna; Weber, E Scott; Marty, Gary D; Hernandez-Divers, Stephen


    Fish patients with cardiovascular disorders present a challenge in terms of diagnostic evaluation and therapeutic options. Veterinarians can approach these cases in fish using methods similar to those employed for other companion animals. Clinicians who evaluate and treat fish in private, aquarium, zoologic, or aquaculture settings need to rely on sound clinical judgment after thorough historical and physical evaluation. Pharmacokinetic data and treatments specific to cardiovascular disease in fish are limited; thus, drug types and dosages used in fish are largely empiric. Fish cardiovascular anatomy, physiology, diagnostic evaluation, monitoring, common diseases, cardiac pathologic conditions, formulary options, and comprehensive references are presented with the goal of providing fish veterinarians with clinically relevant tools.

  15. Carotenoids and cardiovascular health. (United States)

    Voutilainen, Sari; Nurmi, Tarja; Mursu, Jaakko; Rissanen, Tiina H


    Cardiovascular disease (CVD) is the main cause of death in Western countries. Nutrition has a significant role in the prevention of many chronic diseases such as CVD, cancers, and degenerative brain diseases. The major risk and protective factors in the diet are well recognized, but interesting new candidates continue to appear. It is well known that a greater intake of fruit and vegetables can help prevent heart diseases and mortality. Because fruit, berries, and vegetables are chemically complex foods, it is difficult to pinpoint any single nutrient that contributes the most to the cardioprotective effects. Several potential components that are found in fruit, berries, and vegetables are probably involved in the protective effects against CVD. Potential beneficial substances include antioxidant vitamins, folate, fiber, and potassium. Antioxidant compounds found in fruit and vegetables, such as vitamin C, carotenoids, and flavonoids, may influence the risk of CVD by preventing the oxidation of cholesterol in arteries. In this review, the role of main dietary carotenoids, ie, lycopene, beta-carotene, alpha-carotene, beta-cryptoxanthin, lutein, and zeaxanthin, in the prevention of heart diseases is discussed. Although it is clear that a higher intake of fruit and vegetables can help prevent the morbidity and mortality associated with heart diseases, more information is needed to ascertain the association between the intake of single nutrients, such as carotenoids, and the risk of CVD. Currently, the consumption of carotenoids in pharmaceutical forms for the treatment or prevention of heart diseases cannot be recommended.

  16. A model for roll stall and the inherent stability modes of low aspect ratio wings at low Reynolds numbers (United States)

    Shields, Matt

    variation in the Cl ,beta derivative. These are purely aerodynamic modes which are demonstrated to be inherently present in LAR wings. To compare the impact of the roll stability derivative at high and low aspect ratios, a model for roll stall is developed which represents the tip vortices as infinite line vortices and estimates their influence on the surface pressure distribution of the wing; results for the roll moment coefficient are favorably compared with experimental data, and are used to compute Cl ,beta. By estimating the induced spanwise lift acting on a rolling wing, the roll damping derivative may also be computed and, along with the roll stability derivative, used to populate a simplified stability matrix for LAR wings. Solving for the eigenvalues of this system of equations at aspect ratios ranging from the near-unity values applicable to MAVs to high aspect ratio configurations reveals fundamentally different stability regimes. At cruise conditions, aspect ratios below 3.3 do not experience significant roll damping and the large magnitudes of roll stall instigate the divergent Dutch roll mode described by an unstable, complex eigenvalue. At higher aspect ratios above AR = 4.6, the eigenvalues cross into the left side of the complex plane and the lateral mode becomes stable, causing the wing to behave in a conventional, high aspect ratio manner. The disparity in lateral stability regimes between high and low aspect ratios at this Reynolds number suggests a potential explanation for why MAVs are prone to lateral instabilities, as their wings are inherently affected by unique flow physics which are not experienced by more conventional aircraft with a longer span.

  17. Cardiovascular autonomic neuropathy in diabetes

    DEFF Research Database (Denmark)

    Spallone, Vincenza; Ziegler, Dan; Freeman, Roy


    in type 2 diabetes. CAN is a risk marker of mortality and cardiovascular morbidity, and possibly a progression promoter of diabetic nephropathy. Criteria for CAN diagnosis and staging are: 1. one abnormal cardio-vagal test identifies possible or early CAN; 2. at least two abnormal cardio-vagal tests....... diagnosis of CAN clinical forms, 2. detection and tailored treatment of CAN clinical correlates (e.g. tachycardia, OH, nondipping, QT interval prolongation), 3. risk stratification for diabetic complications and cardiovascular morbidity and mortality, and 4. modulation of targets of diabetes therapy......Cardiovascular Autonomic Neuropathy (CAN) Subcommittee of Toronto Consensus Panel on Diabetic Neuropathy worked to update CAN guidelines, with regard to epidemiology, clinical impact, diagnosis, usefulness of CAN testing, and management. CAN is the impairment of cardiovascular autonomic control...

  18. Cognitive dysfunction after cardiovascular surgery

    DEFF Research Database (Denmark)

    Funder, K S; Steinmetz, J; Rasmussen, L S


    This review describes the incidence, risk factors, and long-term consequences of cognitive dysfunction after cardiovascular surgery. Postoperative cognitive dysfunction (POCD) is increasingly being recognized as an important complication, especially in the elderly. A highly sensitive neuropsychol...

  19. [Subclinical hypothyroidism and cardiovascular risk]. (United States)

    López Rubio, María Antonia; Tárraga López, Pedro Juan; Rodríguez Montes, José Antonio; Frías López, María del Carmen; Solera Albero, Juan; Bermejo López, Pablo


    Objetivos: Valorar si el hipotiroidismo subclínico puede comportarse como un factor de riesgo cardiovascular o un modificador del mismo, identificando variables epidemiológicas y riesgo cardiovascular estimado en una muestra de sujetos diagnosticados en la provincia de Albacete. Método: Estudio observacional, descriptivo y transversal realizado en Albacete durante la primera quincena de enero de 2012 en pacientes de ambos géneros con hipotiroidismo subclínico. Se analizaron las siguientes variables: glucemia basal, colesterol total, colesterol HDL, colesterol LDL, triglicéridos, TSH, T4, peso, talla, I.M.C., tensión arterial, antecedentes de patología cardiovascular, factores de riesgo cardiovascular y riesgo cardiovascular estimado. Resultados: Se obtuvieron 326 pacientes, con predominio femenino (79,2 %), menores de 65 años en el 78% y sin factores de riesgo cardiovascular en el 48,61%. La prevalencia de los factores de riesgo cardiovascular identificados fué: tabaquismo (33,2%), diabetes mellitus (24,9%), hipertensión arterial (23,4%), alteraciones lipídicas (28,9%) y fibrilación auricular (4,9 %). No se encontró asociación entre hipotiroidismo subclínico y la mayoría de los parámetros del perfil lipídico que condicionan un perfil pro-aterogénico, salvo con la hipertrigliceridemia. Asimismo, tampoco se constató asociación con riesgo cardiovascular aumentado. Conclusiones: El perfil del paciente con hipotiroidismo subclínico es una mujer de mediana edad sin factores de riesgo cardiovascular en la mitad de casos. Se ha encontrado relación entre hipotiroidismo subclínico e hipertrigliceridemia, pero no con el resto de parámetros del perfil lipídico, otros factores de riesgo cardiovascular o con aumento de dicho riesgo. Sin embargo, un 25% de diabéticos y un 22% de no diabéticos están en situación de riesgo cardiovascular moderado-alto.

  20. Exercise and the Cardiovascular System


    Saeid Golbidi; Ismail Laher


    There are alarming increases in the incidence of obesity, insulin resistance, type II diabetes, and cardiovascular disease. The risk of these diseases is significantly reduced by appropriate lifestyle modifications such as increased physical activity. However, the exact mechanisms by which exercise influences the development and progression of cardiovascular disease are unclear. In this paper we review some important exercise-induced changes in cardiac, vascular, and blood tissues and discuss...

  1. Stress and atherosclerotic cardiovascular disease. (United States)

    Inoue, Nobutaka


    Recent major advances in medical science have introduced a wide variety of treatments against atherosclerosis-based cardiovascular diseases, which has led to a significant reduction in mortality associated with these diseases. However, atherosclerosis-based cardiovascular disease remains a leading cause of death. Furthermore, progress in medical science has demonstrated the pathogenesis of cardiovascular disease to be complicated, with a wide variety of underlying factors. Among these factors, stress is thought to be pivotal. Several types of stress are involved in the development of cardiovascular disease, including oxidative stress, mental stress, hemodynamic stress and social stress. Accumulating evidence indicates that traditional risk factors for atherosclerosis, including diabetes, hyperlipidemia, hypertension and smoking, induce oxidative stress in the vasculature. Oxidative stress is implicated in the pathogenesis of endothelial dysfunction, atherogenesis, hypertension and remodeling of blood vessels. Meanwhile, mental stress is a well-known major contributor to the development of cardiovascular disease. The cardiovascular system is constantly exposed to hemodynamic stress by the blood flow and/or pulsation, and hemodynamic stress exerts profound effects on the biology of vascular cells and cardiomyocytes. In addition, social stress, such as that due to a lack of social support, poverty or living alone, has a negative impact on the incidence of cardiovascular disease. Furthermore, there are interactions between mental, oxidative and hemodynamic stress. The production of reactive oxygen species is increased under high levels of mental stress in close association with oxidative stress. These stress responses and their interactions play central roles in the pathogenesis of atherosclerosis-based cardiovascular disease. Accordingly, the pathophysiological and clinical implications of stress are discussed in this article.

  2. Vitamin D and Cardiovascular Disease


    Vivian Cristina Garcia; Lígia Araújo Martini


    Vitamin D insufficiency/deficiency has been observed worldwide at all stages of life. It has been characterized as a public health problem, since low concentrations of this vitamin have been linked to the pathogenesis of several chronic diseases. Several studies have suggested that vitamin D is involved in cardiovascular diseases and have provided evidence that it has a role in reducing cardiovascular disease risk. It may be involved in regulation of gene expression through the presence of vi...

  3. Vitamin D and Cardiovascular Disease


    Grübler, Martin R.; Martin Gaksch; Thomas Pieber; Katharina Kienreich; Nicolas Verheyen; Andreas Tomaschitz; Stefan Pilz


    Vitamin D deficiency, as well as cardiovascular diseases (CVD) and related risk factors are highly prevalent worldwide and frequently co-occur. Vitamin D has long been known to be an essential part of bone metabolism, although recent evidence suggests that vitamin D plays a key role in the pathophysiology of other diseases, including CVD, as well. In this review, we aim to summarize the most recent data on the involvement of vitamin D deficiency in the development of major cardiovascular risk...

  4. Development of Cardiovascular Indices of Acute Pain Responding in Infants: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Jordana A. Waxman


    Full Text Available Background. Cardiovascular indices of pain are pervasive in the hospital setting. However, no prospective research has examined the development of cardiac responses to acutely painful procedures in the first year of life. Objectives. Our main goal was to synthesize existing evidence regarding the development of cardiovascular responses to acutely painful medical procedures over the first year of life in preterm and term born infants. Methods. A systematic search retrieved 6994 articles to review against inclusion criteria. A total of 41 studies were included in the review. Results. In response to acutely painful procedures, most infants had an increase in mean heart rate (HR that varied in magnitude both across and within gestational and postnatal ages. Research in the area of HR variability has been inconsistent, limiting conclusions. Conclusions. Longitudinal research is needed to further understand the inherent variability of cardiovascular pain responses across and within gestational and postnatal ages and the causes for the variability.

  5. Vitamin D and cardiovascular disease. (United States)

    Norman, P E; Powell, J T


    Vitamin D plays a classical hormonal role in skeletal health by regulating calcium and phosphorus metabolism. Vitamin D metabolites also have physiological functions in nonskeletal tissues, where local synthesis influences regulatory pathways via paracrine and autocrine mechanisms. The active metabolite of vitamin D, 1α,25-dihydroxyvitamin D, binds to the vitamin D receptor that regulates numerous genes involved in fundamental processes of potential relevance to cardiovascular disease, including cell proliferation and differentiation, apoptosis, oxidative stress, membrane transport, matrix homeostasis, and cell adhesion. Vitamin D receptors have been found in all the major cardiovascular cell types including cardiomyocytes, arterial wall cells, and immune cells. Experimental studies have established a role for vitamin D metabolites in pathways that are integral to cardiovascular function and disease, including inflammation, thrombosis, and the renin-angiotensin system. Clinical studies have generally demonstrated an independent association between vitamin D deficiency and various manifestations of degenerative cardiovascular disease including vascular calcification. However, the role of vitamin D supplementation in the management of cardiovascular disease remains to be established. This review summarizes the clinical studies showing associations between vitamin D status and cardiovascular disease and the experimental studies that explore the mechanistic basis for these associations.

  6. [Air pollution and cardiovascular disease]. (United States)

    Haber, Guy; Witberg, Guy; Danenberg, Haim


    Cardiovascular atherothrombosis is the most common cause of death globally, with several well-known risk factors. Air pollution is a byproduct of fuel combustion by motor vehicles, power plants and industrial factories. It is composed of gases, fluids and particulate matter (PM) of different sizes, which include basic carbon, organic carbonic molecules and metals such as vanadium, nickel, zinc and iron. These particles are subdivided by their median size, a major contributing factor for their capability to enter the human body through the respiratory system. Most of the epidemiological studies have shown correlation between acute and long-term exposure to air pollution elements and cardiovascular morbidity in general, and angina pectoris and acute myocardial infarction specifically. Physiological studies have found different arrhythmias as the etiologic cause of cardiovascular morbidity and mortality following exposure to air pollution. A major finding was a decline in heart rate variability, a phenomenon known as endangering for cardiovascular morbidity and mortality, especially in patients after acute myocardial infarction. To date, several pathways have been proposed, including a hypercoagulable state following an inflammatory response, cardiac nervous autonomic disequilibrium, endothelial dysfunction with blood vessel contraction and direct toxic impact on cardiac muscle. Additional research is needed for clarifying the pathophysiological pathways by which air pollution affects the cardiovascular system. That might allow forthcoming with preventive measures and correct treatment, and hence a decrease in cardiovascular morbidity and mortality. Another important target is dose-outcome correlation curves for safety threshold calculation as a basis for air pollution regulations.

  7. Osteoporosis and ischemic cardiovascular disease. (United States)

    Laroche, Michel; Pécourneau, Virginie; Blain, Hubert; Breuil, Véronique; Chapurlat, Roland; Cortet, Bernard; Sutter, Bruno; Degboe, Yannick


    Osteoporosis and cardiovascular disease were long viewed as independent of each other. However, numerous epidemiological studies, which are discussed in the first part of this review, have provided incontrovertible evidence of a link. Thus, the risk of coronary artery disease and stroke is higher in patients with a history of osteoporotic fracture or low bone mineral density than in non-osteoporotic patients. In the other direction, patients with cardiovascular disease are at higher risk for bone loss and osteoporotic fracture. The link between osteoporosis and cardiovascular disease is due in part to shared conventional risk factors such as estrogen deprivation in women, smoking, low physical activity, and diabetes. In addition, atheroma plaque calcification involves cytokines and growth factors that also play a role in bone turnover, including proinflammatory cytokines (IL-6 and TNFα), osteoprotegerin, sclerostin, matrix GLA protein, and FGF-23. Several recent studies have provided support for these pathophysiological hypotheses. Thus, elevation of osteoprotegerin, sclerostin, or FGF-23 levels may explain and predict the occurrence of both osteoporotic fractures and cardiovascular events. The association between osteoporosis and cardiovascular disease found in most epidemiological and pathophysiological studies suggests a need for evaluating potential benefits from routine bone absorptiometry and osteoporotic fracture detection in patients with cardiovascular disease and from exercise testing and arterial Doppler imaging in patients with osteoporosis.

  8. Inherent safety analysis of the KALIMER under a LOFA with a reduced primary pump halving time

    Energy Technology Data Exchange (ETDEWEB)

    Chang, W. P.; Kwon, Y. M.; Jeong, H. Y.; Suk, S. D.; Lee, Y. B. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    The 600 MWe, pool-type, sodium-cooled, metallic fuel loaded KALIMER-600 (Korea Advanced LiquId MEtal Reactor, 600 MWe) has been conceptually designed with an emphasis on safety by self-regulating (inherent/intrinsic) negative reactivity feedback in the core. Its inherent safety under the ATWS (Anticipated Transient Without Scram) events was demonstrated in an earlier study. Initiating events of an HCDA (Hypothetical Core Disruptive Accident), however, also need to be analyzed for assessment of the margins in the current design. In this study, a hypothetical triple-fault accident, ULOF (Unprotected Loss Of Flow) with a reduced pump halving time, is investigated as an initiator of a core disruptive accident. A ULOF with insufficient primary pump inertia may cause core sodium boiling due to a power-to-flow mismatch. If the positive sodium reactivity resulting from this boiling is not compensated for by other intrinsic negative reactivity feedbacks, the resulting core power burst would challenge the fuel integrity. The present study focuses on determination of the limit of the pump inertia for assuring inherent reactivity feedback and behavior of the core after sodium boiling as well. Transient analyses are performed with the safety analysis code SSC-K, which now incorporates a new sodium boiling model. The results show that a halving time of more than 6.0 s does not allow sodium boiling even with very conservative assumptions. Boiling takes place for a halving time of 1.8 s, and its behavior can be predicted reasonably by the SSC-K

  9. Criticality Safety Evaluation of the LLNL Inherently Safe Subcritical Assembly (ISSA)

    Energy Technology Data Exchange (ETDEWEB)

    Percher, Catherine [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    The LLNL Nuclear Criticality Safety Division has developed a training center to illustrate criticality safety and reactor physics concepts through hands-on experimental training. The experimental assembly, the Inherently Safe Subcritical Assembly (ISSA), uses surplus highly enriched research reactor fuel configured in a water tank. The training activities will be conducted by LLNL following the requirements of an Integration Work Sheet (IWS) and associated Safety Plan. Students will be allowed to handle the fissile material under the supervision of LLNL instructors. This report provides the technical criticality safety basis for instructional operations with the ISSA experimental assembly.

  10. Multiformity of inherent randomicity and visitation density in n symbolic dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Yagang [Department of Applied Mathematics, School of Mathematics and Physics, North China Electric Power University, Box 205, Baoding, Hebei 071003 (China) and Center for Nonlinear Complex Systems, Department of Physics, Yunnan University, Kunming, Yunnan 650091 (China)]. E-mail:; Wang Changjiang [Center for Nonlinear Complex Systems, Department of Physics, Yunnan University, Kunming, Yunnan 650091 (China)


    The multiformity of inherent randomicity and visitation density in n symbolic dynamics will be clarified in this paper. These stochastic symbolic sequences bear three features. The distribution of frequency, inter-occurrence times and the alignment of two random sequences are amplified in detail. The features of visitation density in surjective maps presents catholicity and the catholicity in n letters randomicity has the same measure foundation. We hope to offer a symbolic platform that satisfies these stochastic properties and to attempt to study certain properties of DNA base sequences, 20 amino acids symbolic sequences of proteid structure, and the time series that can be symbolic in finance market et al.

  11. Simulation of the inherent turbulence and wake interaction inside an infinitely long row of wind turbines

    DEFF Research Database (Denmark)

    Andersen, Søren Juhl; Sørensen, Jens Nørkær; Mikkelsen, Robert Flemming


    The turbulence in the interior of awind farmis simulated using large eddy simulation and the actuator line technique implemented in the Navier–Stokes equations. The simulations are carried out for an infinitely long row of turbines simulated by applying cyclic boundary conditions at the inlet...... and outlet. The simulations investigate the turbulence inherent to the wind turbines as no ambient turbulence or shear is added to this idealised case. The simulated data give insight into the performance of thewind turbines operating in thewake of others aswell as details on key turbulent quantities. One...

  12. 78 FR 76307 - Cardiovascular and Renal Drugs Advisory Committee; Notice of Meeting (United States)


    ... HUMAN SERVICES Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee; Notice of... to the public. Name of Committee: Cardiovascular and Renal Drugs Advisory Committee. General Function... atherothrombotic events in patients with a history of myocardial infarction (MI). The applicant also proposes...

  13. Safety assessment in plant layout design using indexing approach: implementing inherent safety perspective. Part 2-Domino Hazard Index and case study. (United States)

    Tugnoli, Alessandro; Khan, Faisal; Amyotte, Paul; Cozzani, Valerio


    The design of layout plans requires adequate assessment tools for the quantification of safety performance. The general focus of the present work is to introduce an inherent safety perspective at different points of the layout design process. In particular, index approaches for safety assessment and decision-making in the early stages of layout design are developed and discussed in this two-part contribution. Part 1 (accompanying paper) of the current work presents an integrated index approach for safety assessment of early plant layout. In the present paper (Part 2), an index for evaluation of the hazard related to the potential of domino effects is developed. The index considers the actual consequences of possible escalation scenarios and scores or ranks the subsequent accident propagation potential. The effects of inherent and passive protection measures are also assessed. The result is a rapid quantification of domino hazard potential that can provide substantial support for choices in the early stages of layout design. Additionally, a case study concerning selection among various layout options is presented and analyzed. The case study demonstrates the use and applicability of the indices developed in both parts of the current work and highlights the value of introducing inherent safety features early in layout design.

  14. Cardiovascular Risk Factors and Cardiovascular Hyperreactivity in Young Venezuelans

    Directory of Open Access Journals (Sweden)

    Sady Montes Amador


    Full Text Available Background: cardiovascular hyperreactivity in young people has been associated with different risk factors and a family history of hypertension. Objective: to determine the association between a family history of hypertension and cardiovascular risk factors with cardiovascular hyperreactivity. Method: a correlational, cross-sectional study was conducted in a universe of 77 young individuals aged 18 to 40 years from the Churuguara parish of the Falcon State in Venezuela. The variables were: age, sex, skin color, family history of hypertension, medical history of hypertension, diabetes mellitus, alcohol consumption, salt intake, physical activity and body mass index. The diastolic and systolic blood pressure before and after the pressor response elicited by an isometric exercise were determined as hemodynamic variables. Results: thirteen percent of the participants developed vascular reactivity after the hand-held weight test. Cardiovascular hyperreactivity is three times higher in individuals with a family history of hypertension. Sixty percent of those with a body mass index greater than or equal to 27 kg/m2 are hyperreactive. There is a higher cardiovascular response to the hand-held weight test as the consumption of alcohol increases. Thirty three point three percent of the participants who smoke are hyperreactive. Conclusions: there is a significant association between a family history of hypertension, obesity, salt intake, alcohol consumption and vascular hyperreactivity.

  15. DEM Simulation of Biaxial Compression Experiments of Inherently Anisotropic Granular Materials and the Boundary Effects

    Directory of Open Access Journals (Sweden)

    Zhao-Xia Tong


    Full Text Available The reliability of discrete element method (DEM numerical simulations is significantly dependent on the particle-scale parameters and boundary conditions. To verify the DEM models, two series of biaxial compression tests on ellipse-shaped steel rods are used. The comparisons on the stress-strain relationship, strength, and deformation pattern of experiments and simulations indicate that the DEM models are able to capture the key macro- and micromechanical behavior of inherently anisotropic granular materials with high fidelity. By using the validated DEM models, the boundary effects on the macrodeformation, strain localization, and nonuniformity of stress distribution inside the specimens are investigated using two rigid boundaries and one flexible boundary. The results demonstrate that the boundary condition plays a significant role on the stress-strain relationship and strength of granular materials with inherent fabric anisotropy if the stresses are calculated by the force applied on the wall. However, the responses of the particle assembly measured inside the specimens are almost the same with little influence from the boundary conditions. The peak friction angle obtained from the compression tests with flexible boundary represents the real friction angle of particle assembly. Due to the weak lateral constraints, the degree of stress nonuniformity under flexible boundary is higher than that under rigid boundary.

  16. Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by synthetic circuits. (United States)

    Morel, Mathieu; Shtrahman, Roman; Rotter, Varda; Nissim, Lior; Bar-Ziv, Roy H


    Synthetic gene circuits are emerging as a versatile means to target cancer with enhanced specificity by combinatorial integration of multiple expression markers. Such circuits must also be tuned to be highly sensitive because escape of even a few cells might be detrimental. However, the error rates of decision-making circuits in light of cellular variability in gene expression have so far remained unexplored. Here, we measure the single-cell response function of a tunable logic AND gate acting on two promoters in heterogeneous cell populations. Our analysis reveals an inherent tradeoff between specificity and sensitivity that is controlled by the AND gate amplification gain and activation threshold. We implement a tumor-mimicking cell-culture model of cancer cells emerging in a background of normal ones, and show that molecular parameters of the synthetic circuits control specificity and sensitivity in a killing assay. This suggests that, beyond the inherent tradeoff, synthetic circuits operating in a heterogeneous environment could be optimized to efficiently target malignant state with minimal loss of specificity.

  17. Coarse-Grained Modeling of Genetic Circuits as a Function of the Inherent Time Scales

    CERN Document Server

    Labavic, Darka; Hildegard, Wolfhard Janke; Meyer-Ortmanns,


    From a coarse-grained perspective the motif of a self-activating species, activating a second species which acts as its own repressor, is widely found in biological systems, in particular in genetic systems with inherent oscillatory behavior. Here we consider a specific realization of this motif as a genetic circuit, in which genes are described as directly producing proteins, leaving out the intermediate step of mRNA production. We focus on the effect that inherent time scales on the underlying fine-grained scale can have on the bifurcation patterns on a coarser scale in time. Time scales are set by the binding and unbinding rates of the transcription factors to the promoter regions of the genes. Depending on the ratio of these rates to the decay times of the proteins, the appropriate averaging procedure for obtaining a coarse-grained description changes and leads to sets of deterministic equations, which differ in their bifurcation structure. In particular the desired intermediate range of regular limit cyc...

  18. Are autobiographical memories inherently social? Evidence from an fMRI study.

    Directory of Open Access Journals (Sweden)

    Linda Wilbers

    Full Text Available The story of our lifetime - our narrative self - is constructed from our autobiographical memories. A central claim of social psychology is that this narrative self is inherently social: When we construct our lives, we do so in a real or imagined interaction. This predicts that self-referential processes which are involved in recall of autobiographical memories overlap with processes involved in social interactions. Indeed, previous functional MRI studies indicate that regions in the medial prefrontal cortex (mPFC are activated during autobiographical memory recall and virtual communication. However, no fMRI study has investigated recall of autobiographical memories in a real-life interaction. We developed a novel paradigm in which participants overtly reported self-related and other-related memories to an experimenter, whose non-verbal reactions were being filmed and online displayed to the participants in the scanner. We found that recall of autobiographical vs. non-autobiographical memories was associated with activation of the mPFC, as was recall in the social as compared to a non-social control condition; however, both contrasts involved different non-overlapping regions within the mPFC. These results indicate that self-referential processes involved in autobiographical memory recall are different from processes supporting social interactions, and argue against the hypothesis that autobiographical memories are inherently social.

  19. PBL在任职教育心血管介入培训中的应用研究%Application of PBL in cardiovascular intervention training of continuing education

    Institute of Scientific and Technical Information of China (English)

    赵季红; 周邠玮; 刘新林; 石蕊; 梁国庆; 姜铁民


    目的:比较以问题为基础的学习(problem-based learning,PBL)与传统教学在任职教育心血管介入培训中的应用效果。方法纳入2012年10月至2015年1月在武警后勤学院附属医院介入培训基地的各武警总队进修医师39名。随机分为对照组(19名),按照传统教学方法培训;PBL组(20名),采用PBL七步法,即“弄清不熟悉的术语———界定问题———‘头脑风暴’———重新结构化问题———界定学习目标———收集信息,个人学习———共享信息,小组讨论学习”的流程进行培训。培训结束后两组采用统一试题进行理论与技能考试,以及行教学满意度问卷调查;采用SPSS 18.0对两组进修医师数据行t检验或卡方检验。结果 PBL组进修医师的心血管介入操作[(30.07±1.67) vs.(28.54±1.98),P=0.036]、临床病例综合分析[(34.47±1.77) vs.(32.08±1.80),P=0.002]及总成绩[(86.47±2.75) vs.(82.23±3.63),P=0.002]均优于对照组,且差异有统计学意义。问卷调查结果显示, PBL组对所用教学方法在激发学习兴趣、提升独立思考能力、培养团队协作能力、改善语言表达及提高临床思维等方面的评价优良率均高于对照组(P<0.05)。结论 PBL在任职教育心血管介入培训中的应用效果与传统教学相比,可以更好地发挥学员主观能动性,提高教学效果。%Objective To compare the application effect between problem-based learning (PBL) and traditional teaching in cardiovascular intervention . Methods 39 training physicians were divided randomly into the PBL group (n=20) and control group (n=19). The control group was trained with the tradi-tional teaching method while PBL group used PBL seven step method, namely they were trained through the process of clarifying unfamiliar terms—defining the problem—brainstorming—restructuring problem—defining learning

  20. Big data analytics to improve cardiovascular care: promise and challenges. (United States)

    Rumsfeld, John S; Joynt, Karen E; Maddox, Thomas M


    The potential for big data analytics to improve cardiovascular quality of care and patient outcomes is tremendous. However, the application of big data in health care is at a nascent stage, and the evidence to date demonstrating that big data analytics will improve care and outcomes is scant. This Review provides an overview of the data sources and methods that comprise big data analytics, and describes eight areas of application of big data analytics to improve cardiovascular care, including predictive modelling for risk and resource use, population management, drug and medical device safety surveillance, disease and treatment heterogeneity, precision medicine and clinical decision support, quality of care and performance measurement, and public health and research applications. We also delineate the important challenges for big data applications in cardiovascular care, including the need for evidence of effectiveness and safety, the methodological issues such as data quality and validation, and the critical importance of clinical integration and proof of clinical utility. If big data analytics are shown to improve quality of care and patient outcomes, and can be successfully implemented in cardiovascular practice, big data will fulfil its potential as an important component of a learning health-care system.

  1. A Sensitive and Biodegradable Pressure Sensor Array for Cardiovascular Monitoring. (United States)

    Boutry, Clementine M; Nguyen, Amanda; Lawal, Qudus Omotayo; Chortos, Alex; Rondeau-Gagné, Simon; Bao, Zhenan


    An array of highly sensitive pressure sensors entirely made of biodegradable materials is presented, designed as a single-use flexible patch for application in cardiovascular monitoring. The high sensitivity in combination with fast response time is unprecedented when compared to recent reports on biodegradable pressure sensors (sensitivity three orders of magnitude higher), as illustrated by pulse wave velocity measurements, toward hypertension detection.

  2. Osteoporosis y enfermedad cardiovascular

    Directory of Open Access Journals (Sweden)

    Sarahí Mendoza


    Full Text Available Las enfermedades cardiovasculares (ECV y la osteoporosis son causas frecuentes de morbilidad en la población adulta, cuya frecuencia aumenta con la edad, por lo que al aumentar la expectativa de vida, constituyen importantes problemas de salud. El riesgo a padecer ambas patologías depende de factores de riesgo, y la prevención consiste en controlar los modificables. Las ECV y la osteoporosis presentan factores etiológicos comunes que involucran la biosíntesis del colesterol y la oxidación lipídica, cuya dilucidación representa una línea priorizada de investigación. El crecimiento y mantenimiento del esqueleto depende del equilibrio entre la formación y la resorción ósea a través de los procesos de modelado y remodelado óseo, controlados por células óseas (osteoblastos -OB-, osteoclastos -OC- y osteocitos, los OB son responsables de la formación ósea, los OC de la resorción ósea y los osteocitos de la red mecano sensorial. Entre los nexos de las ECV y la osteoporosis se encuentra el papel de la vía del mevalonato en la síntesis de colesterol y en la activación de OC, y el papel de los lípidos oxidados en el desarrollo de la aterosclerosis y en la transformación de las células precursoras de OB en adipocitos, disminuyendo la formación de OB activos y favoreciendo la osteoporosis. Ello justifica que sustancias hipolipemiantes y antioxidantes puedan ejercer efectos protectores sobre el hueso, y que la búsqueda de sustancias que actúen sobre ambos blancos sea un aspecto de interés en la prevención o el manejo de estas enfermedades.

  3. 护理风险管理在心血管内科护理中的应用%Application of nursing risk management in the department of cardiovascular internal medicine

    Institute of Scientific and Technical Information of China (English)



    Objective:To explore the application effect of nursing risk management in department of cardiovascular internal medicine.Methods:200 patients hospitalized in the department of cardiovascular internal medicine were selected from January 2013 to August 2014 as the observation group.200 patients admitted to hospital were selected from March 2012 to December 2012 as the control group.Patients in the control group were given the general nursing,while in the observation group were strict implementation of nursing operation rules,formulate risk management of nursing interventions for patients.Results:In the observation group there occurred 3 cases of adverse events,and the incidence of adverse events was 1.5%.There was 1 cases of medication errors,1 cases of pipeline fall off and 1 cases of accidental injury.192 patients were satisfact,and the satisfaction rate was 96%.In the control group there were 10 cases of adverse events,the incidence of adverse events was 5%,there were 2 cases of medication errors,2 cases of lines fall,3 cases of pressure sore,3 cases accidental injury in.168 patients were satisfact,the satisfaction rate was 84%.The difference was statistically significant between the two groups(P<0.05).Conclusion:Implementation of nursing risk management in department of ardiovascular internal medicine can significantly reduce nursing events and improve the satisfaction of patients,so it is worthy of clinical promotion.%目的:探讨护理风险管理在心血管内科的应用效果。方法:2013年1月-2014年8月收治心血管内科住院患者200例作为观察组,2012年3月-2012年12月收治住院患者200例作为对照组。对照组进行一般的护理,观察组严格执行护理操作规程,制定护理风险管理干预措施,对患者进行护理干预。结果:观察组共发生不良事件3例,不良事件发生率1.5%,其中给药错误1例,管路脱落1例,意外伤害1例。患者满意192例,满意度96.0%。

  4. Application of bioinformatics in cardiovascular genomics

    NARCIS (Netherlands)

    Tragante Do O, V.


    Genetic research made a remarkable progress in the past 20 years, with the Human Genome Project, which sequenced an entire genome; the HapMap project, that identified common genetic variation in hundreds of genomes from different populations; and the 1000 Genomes project, which identified common and

  5. Vitamin D and Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Martin R. Grübler


    Full Text Available Vitamin D deficiency, as well as cardiovascular diseases (CVD and related risk factors are highly prevalent worldwide and frequently co-occur. Vitamin D has long been known to be an essential part of bone metabolism, although recent evidence suggests that vitamin D plays a key role in the pathophysiology of other diseases, including CVD, as well. In this review, we aim to summarize the most recent data on the involvement of vitamin D deficiency in the development of major cardiovascular risk factors: hypertension, obesity and dyslipidemia, type 2 diabetes, chronic kidney disease and endothelial dysfunction. In addition, we outline the most recent observational, as well as interventional data on the influence of vitamin D on CVD. Since it is still an unresolved issue whether vitamin D deficiency is causally involved in the pathogenesis of CVD, data from randomized controlled trials (RCTs designed to assess the impact of vitamin D supplementation on cardiovascular outcomes are awaited with anticipation. At present, we can only conclude that vitamin D deficiency is an independent cardiovascular risk factor, but whether vitamin D supplementation can significantly improve cardiovascular outcomes is still largely unknown.

  6. [Iodine deficiency in cardiovascular diseases]. (United States)

    Molnár, I; Magyari, M; Stief, L


    The thyroid hormone deficiency on cardiovascular function can be characterized with decreased myocardial contractility and increased peripheral vascular resistance as well as with the changes in lipid metabolism. 42 patients with cardiovascular disease (mean age 65 +/- 13 yr, 16 males) were investigated if iodine insufficiency can play a role as a risk factor for the cardiovascular diseases. The patients were divided in 5 subgroups on the ground of the presence of hypertension, congestive heart failure, cardiomyopathy, coronary disfunction and arrhythmia. Urine iodine concentration (5.29 +/- 4.52 micrograms/dl) was detected with Sandell-Kolthoff colorimetric reaction. The most decreased urine iodine concentration was detected in the subgroups with arrhythmia and congestive heart failure (4.7 +/- 4.94 micrograms/dl and 4.9 +/- 4.81 micrograms/dl, respectively). An elevated TSH level was found by 3 patients (5.3 +/- 1.4 mlU/l). An elevation in lipid metabolism (cholesterol, triglyceride) associated with all subgroups without arrhythmia. In conclusion, the occurrence of iodine deficiency in cardiovascular disease is frequent. Iodine supplementation might prevent the worsing effect of iodine deficiency on cardiovascular disease.

  7. Cardiovascular benefits of bariatric surgery. (United States)

    Lee, Glenn K; Cha, Yong-Mei


    The prevalence of obesity is increasing in the United States and worldwide, bringing with it an excess of morbidity and premature death. Obesity is strongly associated with both traditional cardiovascular risk factors as well as direct effects on hemodynamics and cardiovascular structure and function. In fact, cardiovascular disease is one of the major causes of morbidity and mortality in obese patients. Often, lifestyle and pharmacological weight-loss interventions are of limited efficacy in severely obese patients. Bariatric surgery has been shown to be a feasible option to achieve substantial and sustained weight loss in this group of patients. It is a safe procedure with low in-hospital and 30-day mortality rates even in groups that are considered higher risk for surgery (e.g., the elderly), especially if performed in high-volume centers. There is observational evidence that bariatric surgery in severely obese patients is associated with both a reduction of traditional cardiovascular risk factors as well as improvement in cardiac structure and function. Marked decreases in the levels of inflammatory and prothrombotic markers, as well as markers of subclinical atherosclerosis and endothelial dysfunction, are seen after bariatric surgery. This article summarizes the existing evidence regarding the cardiovascular benefits in patients following bariatric surgery.

  8. Exercise detraining: Applicability to microgravity (United States)

    Coyle, Edward F.


    Physical training exposes the various systems of the body to potent physiologic stimuli. These stimuli induce specific adaptations that enhance an individual's tolerance for the type of exercise encountered in training. The level of adaptation and the magnitude of improvement in exercise tolerance is proportional to the potency of the physical training stimuli. Likewise, our bodies are stimulated by gravity, which promotes adaptations of both the cardiovascular and skeletal muscles. Exposure to microgravity removes normal stimuli to these systems, and the body adapts to these reduced demands. In many respects the cessation of physical training in athletes and the transition from normal gravity to microgravity represent similar paradigms. Inherent to these situations is the concept of the reversibility of the adaptations induced by training or by exposure to normal gravity. The reversibility concept holds that when physical training is stopped (i.e., detraining) or reduced, or a person goes from normal gravity to microgravity, the bodily systems readjust in accordance with the diminished physiologic stimuli. The focus of this chapter is on the time course of loss of the adaptations to endurance training as well as on the possibility that certain adaptations persist, to some extent, when training is stopped. Because endurance exercise training generally improves cardiovascular function and promotes metabolic adaptations within the exercising skeletal musculature, the reversibility of these specific adaptations is considered. These observations have some applicability to the transition from normal to microgravity.

  9. Selecting Molecular Recognition. What Can Existing Aptamers Tell Us about Their Inherent Recognition Capabilities and Modes of Interaction?

    Directory of Open Access Journals (Sweden)

    Ralf Landgraf


    Full Text Available The use of nucleic acid derived aptamers has rapidly expanded since the introduction of SELEX in 1990. Nucleic acid aptamers have demonstrated their ability to target a broad range of molecules in ways that rival antibodies, but advances have been very uneven for different biochemical classes of targets, and clinical applications have been slow to emerge. What sets different aptamers apart from each other and from rivaling molecular recognition platforms, specifically proteins? What advantages do aptamers as a reagent class offer, and how do the chemical properties and selection procedures of aptamers influence their function? Do the building blocks of nucleic acid aptamers dictate inherent limitations in the nature of molecular targets, and do existing aptamers give us insight in how these challenges might be overcome? This review is written as an introduction for potential endusers of aptamer technology who are evaluating the advantages of aptamers as a versatile, affordable, yet highly expandable platform to target a broad range of biological processes or interactions.

  10. Summarization of teaching experience of cardiovascular system integrated course

    Institute of Scientific and Technical Information of China (English)

    Li-dong ZU; Jing-long WANG; Lei ZHAO; Shen CAI; Shao-bo LI; Guo-hui FU


    Cardiovascular system plays an important role in the medical curriculum.How to enable medical students better learn and grasp this part of knowledge is a task and mission faced by teachers.In recent years,with the development and reform of medical teaching,the application of integrated teaching is more and more popular in domestic medical schools.Shanghai Jiao Tong University School of Medicine has also adopted the integrated teaching.As pathology teachers,we take the integrated teaching of cardiovascular system course as an example to introduce our experience.

  11. The cardiovascular action of hexarelin

    Institute of Scientific and Technical Information of China (English)

    wYuanjie MAO; Takeshi Tokudome; Ichiro Kishimoto


    Hexarelin, a synthetic growth hormone-releasing peptide, can bind to and activate the growth hormone secretagogue receptor (GHSR) in the brain similar to its natural analog ghrelin. However, the peripheral distribution of GHSR in the heart and blood vessels suggests that hexarelin might have direct cardiovascular actions beyond growth hormone release and neuroendocrine effects. Furthermore, the non-GHSR CD36 had been demonstrated to be a specific cardiac receptor for hexarelin and to mediate its cardioprotective effects. When compared with ghrelin, hexarelin is chemically more stable and functionally more potent. Therefore, it may be a promising therapeutic agent for some car-diovascular conditions. In this concise review, we discuss the current evidence for the cardiovascular action of hexarelin.

  12. Mitochondrial cytopathies and cardiovascular disease. (United States)

    Dominic, Elizabeth A; Ramezani, Ali; Anker, Stefan D; Verma, Mukesh; Mehta, Nehal; Rao, Madhumathi


    The global epidemic of cardiovascular disease remains the leading cause of death in the USA and across the world. Functional and structural integrity of mitochondria are essential for the physiological function of the cardiovascular system. The metabolic adaptation observed in normal heart is lost in the failing myocardium, which becomes progressively energy depleted leading to impaired myocardial contraction and relaxation. Uncoupling of electron transfer from ATP synthesis leads to excess generation of reactive species, leading to widespread cellular injury and cardiovascular disease. Accumulation of mitochondrial DNA mutation has been linked to ischaemic heart disease, cardiomyopathy and atherosclerotic vascular disease. Mitochondria are known to regulate apoptotic and autophagic pathways that have been shown to play an important role in the development of cardiomyopathy and atherosclerosis. A number of pharmacological and non-pharmacological treatment options have been explored in the management of mitochondrial diseases with variable success.

  13. Electrocardiographic Predictors of Cardiovascular Mortality

    Directory of Open Access Journals (Sweden)

    Ioana Mozos


    Full Text Available Cardiovascular diseases are the main causes of mortality. Sudden cardiac death may also appear in athletes, due to underlying congenital or inherited cardiac abnormalities. The electrocardiogram is used in clinical practice and clinical trials, as a valid, reliable, accessible, inexpensive method. The aim of the present paper was to review electrocardiographic (ECG signs associated with cardiovascular mortality and the mechanisms underlying those associations, providing a brief description of the main studies in this area, and consider their implication for clinical practice in the general population and athletes. The main ECG parameters associated with cardiovascular mortality in the present paper are the P wave (duration, interatrial block, and deep terminal negativity of the P wave in V1, prolonged QT and Tpeak-Tend intervals, QRS duration and fragmentation, bundle branch block, ST segment depression and elevation, T waves (inverted, T wave axes, spatial angles between QRS and T vectors, premature ventricular contractions, and ECG hypertrophy criteria.

  14. Cardiovascular risks of antiretroviral therapies. (United States)

    Mondy, Kristin; Tebas, Pablo


    The use of highly active antiretroviral therapy (HAART) has resulted in sustained reductions in mortality from HIV infection. In recent years, HAART has also been associated with metabolic complications that may increase patients' cardiovascular disease risk. Recent studies have begun to support a more complex interaction between HAART, HIV infection itself, and other traditional social and immunologic factors that may predispose patients to premature cardiovascular disease. Substantial progress has been made in the development of newer antiretroviral therapies that have a better metabolic profile with respect to dyslipidemia, hyperglycemia, and lipodystrophy. Optimal selection of metabolically neutral antiretroviral therapies, together with aggressive management of other modifiable coronary risk factors, may improve cardiovascular disease risk in the long term.

  15. Social factors and cardiovascular morbidity. (United States)

    Brunner, Eric John


    Recent progress in population health at aggregate level, measured by life expectancy, has been accompanied by lack of progress in reducing the difference in health prospects between groups defined by social status. Cardiovascular disease is an important contributor to this undesirable situation. The stepwise gradient of higher risk with lower status is accounted for partly by social gradients in health behaviors. The psychosocial hypothesis provides a stronger explanation, based on social patterning of living and working environments and psychological assets that individuals develop during childhood. Three decades of research based on Whitehall II and other cohort studies provide evidence for psychosocial pathways leading to cardiovascular morbidity and mortality. Job stress is a useful paradigm because exposure is long term and depends on occupational status. Studies of social-biological translation implicate autonomic and neuroendocrine function among the biological systems that mediate between chronic adverse psychosocial exposures and increased cardiometabolic risk and cardiovascular disease incidence.

  16. [Cardiovascular manifestations of human toxocariasis]. (United States)

    Bolívar-Mejía, Adrián; Rodríguez-Morales, Alfonso J; Paniz-Mondolfi, Alberto E; Delgado, Olinda


    Toxocariasis is a parasitic infection produced by helminths that cannot reach their adult stage in humans. For their etiological species (Toxocara canis and Toxocara cati), man is a paratenic host. Infection by such helminths can produce a variety of clinical manifestations, such as: visceral larvae migrans syndrome, ocular larvae migrans syndrome and covert toxocariasis. In the visceral larvae migrans syndrome, the organs that are mainly involved include liver, lungs, skin, nervous system, muscles, kidneys and the heart. Regarding the latter, the importance of cardiovascular manifestations in toxocariasis, as well as its clinical relevance, has increasingly begun to be recognized. The current article is based on a systematic information search, focused mainly on the clinical and pathological aspects of cardiovascular manifestations in toxocariasis, including its pathophysiology, laboratory findings, diagnosis and therapeutical options, with the objective of highlighting its importance as a zoonosis and its relevance to the fields of cardiovascular medicine in adults and children.


    Directory of Open Access Journals (Sweden)

    Suceveanu Mihaela


    Full Text Available Background. Cardiovascular rehabilitation is an important objective of the treatment of cardiovascular patients in general, and ischemic heart disease patients in particular. The aim of the study is to monitor the effects of long-term cardiovascular rehabilitation in patients readmitted to the “Dr Benedek Geza” Hospital of Rehabilitation in Cardiovascular Diseases Covasna. Material and methods. The study included 92 patients with a mean age of 66.31±9 years, of which 63% women, who had two successive admissions to the “Dr Benedek Geza” Hospital of Rehabilitation in Cardiovascular Diseases, Covasna. At both admissions, all patients were evaluated for the presence of the main cardiovascular risk factors. All patients attended cardiovascular rehabilitation programs, including physical training, climatotherapy, CO2 baths, mofette therapy, aerotherapy, electrotherapy .. We mention that cardioprotective therapy (aspirin, angiotensin enzyme converting inhibitors, beta-blockers and statins did not undergo major changes from one admission to the other. Results. More than half of the patients had the following risk factors: hypertension - 79.35%, dyslipidemia - 64.13%, overweight and obesity - 76.4%. The complex rehabilitation programs attended by the patients consisted of physical training - 33.7%, CO2 baths - 85.9%, mofette therapy - 53.3%, aerotherapy - 96.7%, electrotherapy - 88%. A comparison of the main cardiovascular risk factors during both admissions showed no significant differences between these, except for LDL-cholesterol (3.151.26 vs 2.581.65 mmol/dl, p=0.004 and HDL-cholesterol (1.06±0.61 vs 1.194±0.41 mmol/dl, p=0.075 In conclusion, in cardiovascular patients, obtaining improvements of cardiovascular risk factors requires long-term cardiovascular rehabilitation programs, in parallel to the application of measures for lifestyle change and for secondary drug prevention.

  18. Apparent and inherent optical properties of turbid estuarine waters: measurements, empirical quantification relationships, and modeling (United States)

    Doxaran, David; Cherukuru, Nagur; Lavender, Samantha J.


    Spectral measurements of remote-sensing reflectance (Rrs) and absorption coefficients carried out in three European estuaries (Gironde and Loire in France, Tamar in the UK) are presented and analyzed. Typical Rrs and absorption spectra are compared with typical values measured in coastal waters. The respective contributions of the water constituents, i.e., suspended sediments, colored dissolved organic matter, and phytoplankton (characterized by chlorophyll-a), are determined. The Rrs spectra are then reproduced with an optical model from the measured absorption coefficients and fitted backscattering coefficients. From Rrs ratios, empirical quantification relationships are established, reproduced, and explained from theoretical calculations. These quantification relationships were established from numerous field measurements and a reflectance model integrating the mean values of the water constituents' inherent optical properties. The model's sensitivity to the biogeochemical constituents and to their nature and composition is assessed.


    Directory of Open Access Journals (Sweden)



    Full Text Available Steganography is the art and science of writing hidden messages in such a way that no one, apart from the sender and intended recipient, suspects the existence of the message, a form of security through obscurity. The advantage of steganography, over cryptography alone, is that messages do not attract attention to themselves. Cryptography protects the contents of a message, steganography can be said to protect both messages and communicating parties. Wide ranges of algorithms have been introduced using text, audio, video and imagesfiles as covering media. This paper presents a new approach for steganography in Telugu texts. Taking the typical structure of Telugu alphabets into consideration, in this approach, by shifting inherent vowel signs either left or right, we hide the secret message. The approach shows good result on the sample collected from differentTelugu newspaper.

  20. The Limits of Logic-Based Inherent Safety of Social Robots

    DEFF Research Database (Denmark)

    Bentzen, Martin Mose


    Social robots can reason and act while taking into accountsocial and cultural structures, for instance by complying withsocial or ethical norms or values. As social robots are likely to becomemore common and advanced and thus likely to interact withhuman beings in increasingly complex situations......-based safety for ethical robots is shown. Afterwards,an empirical study is used to show that there is a clash betweendeontic reasoning and most formal deontic logics. I give anexample as to how this clash can cause problems in human-robot interaction.I conclude that deontic logics closer to natural......, ensuring safety insuch situations will become very important. In this chapter, I investigatethe safety of social robots, focusing on the idea that robotsshould be logically guaranteed to act in a certain way, here calledlogic-based inherent safety. A meta-logical limitation of a particularprogram for logic...

  1. Designs Characteristics and Main Inherent Concerns of the Antiproton Decelerator Target

    CERN Document Server

    Torregrosa, C; Calviani, M


    In the context of AD area consolidation activities a redesign of the AD-target is planned. The information presented in this report is a starting point to this purpose. The current design dates from late 80’s and it was obtained after more than 10 years of iterations and improvements of the material choices and conceptual designs due to the complexity of physical phenomena occurring inside the target material. The present report summarizes this process from the existing documents found in the literature as well as the inherent concerns which will have to be faced in the future design. Two major concerns which limit the target operation life were identified (i) shock wave effects and (ii) radiation damage. Therefore, a deep study of these phenomena and development of reliable models will be the way forward for the next steps in the re-design process.

  2. Utopia and Debt in Postmodernity; or, Time Management in Inherent Vice

    Directory of Open Access Journals (Sweden)

    James Liner


    Full Text Available The category of postmodernism has come under renewed scrutiny in recent years. Indeed, it has become rather commonplace to pronounce the death or obsolescence of postmodernism today. Unsurprisingly, the increasingly questioned status of postmodernism also impacts the field of Pynchon studies. This article reads 'Inherent Vice' as symptomatic not of the end but of a transformation of postmodernism and postmodernity. Pynchon’s novel simultaneously registers a contemporary intensification of postmodern/late capitalism and, crucially, participates in a minor current in postmodernism, one which insists on collective agency and utopian thinking despite the atomization and isolation of subjects accomplished by late capitalism and which, against all odds, remembers how to think historically—or better, invents new ways of thinking historically.

  3. Realignment of Nanocrystal Aggregates into Single Crystals as a Result of Inherent Surface Stress

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Zhaoming [Department of Chemistry, Zhejiang University, Hangzhou Zhejiang 310027 China; Pan, Haihua [Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou Zhejiang 310027 China; Zhu, Genxing [Department of Chemistry, Zhejiang University, Hangzhou Zhejiang 310027 China; Li, Yaling [Department of Chemistry, Zhejiang University, Hangzhou Zhejiang 310027 China; Tao, Jinhui [Physical Sciences Division, Pacific Northwest National Laboratory, Richland WA 99354 USA; Jin, Biao [Department of Chemistry, Zhejiang University, Hangzhou Zhejiang 310027 China; Tang, Ruikang [Department of Chemistry, Zhejiang University, Hangzhou Zhejiang 310027 China; Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou Zhejiang 310027 China


    Assembly of nanoparticles building blocks during single crystal growth is widely observed in both natural and synthetic environments. Although this form of non-classical crystallization is generally described by oriented attachment, random aggregation of building blocks leading to single crystal products is also observed, but the mechanism of crystallographic realignment is unknown. We herein reveal that random attachment during aggregation-based growth initially produces a non-oriented growth front. Subsequent evolution of the orientation is driven by the inherent surface stress applied by the disordered surface layer and results in single crystal formation via grain boundary migration. This mechanism is corroborated by measurements of orientation rate vs external stress, demonstrating a predictive relationship between the two. These findings advance our understanding of aggregation-based growth of natural minerals by nanocrystals, and suggest an approach to material synthesis that takes advantage of stress induced co-alignment.

  4. On the fundamentals of nuclear reactor safety assessment. Inherent threats and their implications

    Energy Technology Data Exchange (ETDEWEB)

    Hyvaerinen, J. [Finnish Centre for Radiation and Nuclear Safety, Helsinki (Finland). Nuclear Safety Dept.


    The thesis addresses some fundamental questions related to implementation and assessment of nuclear safety. The safety principles and assessment methods are described, followed by descriptions of selected novel technical challenges to nuclear safety. The novel challenges encompass a wide variety of technical issues, thus providing insights on the limitations of conventional safety assessment methods. Study of the limitations suggests means to improve nuclear reactor design criteria and safety assessment practices. The novel safety challenges discussed are (1) inherent boron dilution in PWRs, (2) metallic insulation performance with respect to total loss of emergency cooling systems in a loss-of-coolant accident, and (3) horizontal steam generator heat transfer performance at natural circulation conditions. (50 refs.).

  5. On the Parameterization of Convective Entrainment:Inherent Relationships among Entrainment Parameters in Bulk Models

    Institute of Scientific and Technical Information of China (English)

    SUN Jianning


    In this paper,the equilibrium entrainment into a shear-free,linearly stratified atmosphere is discussed under the framework of bulk models,namely,the zero-order jump model (ZOM) and the first-order jump model (FOM).The parameterizations for the dimensionless entrainment rate versus the convective Richardson number in the two models are compared.Based on the assumption that the parameterized entrainment rates in ZOM and FOM should be the same,the inherent relationships among the entrainment parameters in the bulk models are revealed.These relationships are supported by tank experiments and large-eddy simulations.The validity of these inherent relationships indicates that,for a convective boundary layer growing into a linearly stratified free atmosphere,the only dominant factors of the growth rate are the turbulent buoyancy in the mixed layer and the stratification in the free atmosphere.In the point of the similarity view,the former is characterized by turbulent temperature and mixing length scales (mixed layer depth),and the latter is characterized by the lapse rate of potential temperature in the free atmosphere.Thus,the commonly-used Richardson number scheme for the parameterization of the entrainment rate is just as an equivalent description.The variability of the total entrainment flux ratio in FOM,which is connected with the entrainment zone thickness,can implicitly describe the effect of the stratification in the free atmosphere,but the entrainment zone thickness is not an independent parameter.These results demonstrate the validity of the hypothesis that there exists a similarity limit in which the mixed layer depth is the only lengthscale.

  6. The inherent weaknesses in industrial control systems devices; hacking and defending SCADA systems (United States)

    Bianco, Louis J.

    The North American Electric Reliability Corporation (NERC) is about to enforce their NERC Critical Infrastructure Protection (CIP) Version Five and Six requirements on July 1st 2016. The NERC CIP requirements are a set of cyber security standards designed to protect cyber assets essential the reliable operation of the electric grid. The new Version Five and Six requirements are a major revision to the Version Three (currently enforced) requirements. The new requirements also bring substations into scope alongside Energy Control Centers. When the Version Five requirements were originally drafted they were vague, causing in depth discussions throughout the industry. The ramifications of these requirements has made owners look at their systems in depth, questioning how much money it will take to meet these requirements. Some owners saw backing down from routable networks to non-routable as a means to save money as they would be held to less requirements within the standards. Some owners saw removing routable connections as a proper security move. The purpose of this research was to uncover the inherent weaknesses in Industrial Control Systems (ICS) devices; to show how ICS devices can be hacked and figure out potential protections for these Critical Infrastructure devices. In addition, this research also aimed to validate the decision to move from External Routable connectivity to Non-Routable connectivity, as a security measure and not as a means of savings. The results reveal in order to ultimately protect Industrial Control Systems they must be removed from the Internet and all bi-directional external routable connections must be removed. Furthermore; non-routable serial connections should be utilized, and these non-routable serial connections should be encrypted on different layers of the OSI model. The research concluded that most weaknesses in SCADA systems are due to the inherent weaknesses in ICS devices and because of these weaknesses, human intervention is

  7. Nitric oxide and cardiovascular system. (United States)

    Cengel, Atiye; Sahinarslan, Asife


    Endothelium has many important functions including the control of blood-tissue permeability and vascular tonus, regulation of vascular surface properties for homeostasis and inflammation. Nitric oxide is the chief molecule in regulation of endothelial functions. Nitric oxide deficiency, which is also known as endothelial dysfunction, is the first step for the occurrence of many disease states in cardiovascular system including heart failure, hypertension, dyslipidemia, insulin resistance, diabetes mellitus, hyperhomocysteinemia and smoking. This review deals with the importance of nitric oxide for cardiovascular system. It also includes the latest improvements in the diagnosis and treatment of endothelial dysfunction.

  8. Nonfasting hyperlipidemia and cardiovascular disease

    DEFF Research Database (Denmark)

    Nordestgaard, B G; Langsted, A; Freiberg, J J


    lipoproteins into the arterial intima with subsequent retention leading to atherogenesis, while low HDL cholesterol levels may be an innocent bystander. Finally, nonfasting levels of total cholesterol, non-HDL cholesterol, LDL cholesterol, apolipoprotein B, triglycerides, HDL cholesterol, apolipoprotein A1......, total cholesterol/HDL cholesterol, and apolipoprotein B/apolipoprotein A1 all associate with increased risk of cardiovascular disease. These new data open the possibility that nonfasting rather than fasting lipid profiles can be used for cardiovascular risk prediction. If implemented, this would...

  9. Cardiovascular risk with subclinical hyperthyroidism and hypothyroidism: pathophysiology and management. (United States)

    Duggal, Jasleen; Singh, Sarabjeet; Barsano, Charles P; Arora, Rohit


    Previous studies have suggested that subclinical thyroid dysfunction, as manifested by abnormalities in thyroid-stimulating hormone (TSH) levels, are associated with detrimental effects on the cardiovascular system. Subclinical hypothyroidism is characterized by abnormal lipid metabolism, cardiac dysfunction, diastolic hypertension conferring an elevated risk of atherosclerosis, and ischemic heart disease. Similarly, patients with subclinical hyperthyroidism have nearly 3 times the likelihood of atrial fibrillation over a 10-year follow-up interval, raising the question of whether patients with subclinical hyperthyroidism should be treated to prevent atrial fibrillation. A single measurement of low serum TSH in individuals aged 60 years or older has been reported to be associated with increased mortality from all causes and in particular from circulatory and cardiovascular disease in a 10-year follow-up study. Subclinical thyroid dysfunction is currently the subject of numerous studies and remains controversial, particularly as it relates to cardiovascular morbidity and mortality and clinical applications.

  10. Molecular diagnostic technique in the diagnosis of cardiovascular disease:application and challenge%分子诊断技术在心血管疾病诊疗中的应用与挑战

    Institute of Scientific and Technical Information of China (English)

    黄山; 张春阳


    Application ofmolecular diagnostic technique has shown greatpotential and technical advantages in the diagnosis and treatment of cardiovascular disease ( CVD ) .It can be used toscreening , diagnosis , treatment and prognostic evaluation of CVD disease .Early screening helps to notice the risk of the disease, make us take appropriate measures to reduce the health care costs and improve outcomes .To achieve the highest diagnostic efficiency by applying different molecular diagnostic strategies in different diseases.In term of treatment, molecular diagnostic technologies are mainly used in the drug discovery , personalized drug therapy and treatment options; In addition, prognostic assessment of CVD is also an important development direction of molecular diagnostic technique .However, there are severe challenges remained in applying molecular diagnostic techniques in CVD disease , such as the basic andclinicalapplication research and the quality control , etc.%分子诊断技术在心血管疾病诊疗上的应用,已经显示了巨大的潜力和技术优势,可用于心血管疾病的筛查、诊断、治疗和预后评价。筛查有助于预告疾病风险、提早采取相应措施降低医疗成本和改善预后;对不同的疾病采用不同的分子诊断策略,可以达到最佳的诊断效能;分子诊断技术在治疗方面主要应用于新药研发、个性化药物治疗和治疗方案选择;对心血管疾病进行预后评估也是分子诊断技术的重要发展方向。分子诊断技术在心血管疾病的基础和临床应用研究、质量管理等方面,也存在着严峻的挑战。(中华检验医学杂志,2015,38:433-435)

  11. A New Approach to Teaching Human Cardiovascular Physiology Using Doppler Ultrasound. (United States)

    Looker, T.


    Explains the principles of the Doppler ultrasound technique and reviews its potential applications to the teaching of cardiovascular physiology. Identifies the instrumentation needed for this technique; provides examples and illustrations of the waveforms from the ultrasound blood velocimeter. (ML)

  12. Credit scores, cardiovascular disease risk, and human capital. (United States)

    Israel, Salomon; Caspi, Avshalom; Belsky, Daniel W; Harrington, HonaLee; Hogan, Sean; Houts, Renate; Ramrakha, Sandhya; Sanders, Seth; Poulton, Richie; Moffitt, Terrie E


    Credit scores are the most widely used instruments to assess whether or not a person is a financial risk. Credit scoring has been so successful that it has expanded beyond lending and into our everyday lives, even to inform how insurers evaluate our health. The pervasive application of credit scoring has outpaced knowledge about why credit scores are such useful indicators of individual behavior. Here we test if the same factors that lead to poor credit scores also lead to poor health. Following the Dunedin (New Zealand) Longitudinal Study cohort of 1,037 study members, we examined the association between credit scores and cardiovascular disease risk and the underlying factors that account for this association. We find that credit scores are negatively correlated with cardiovascular disease risk. Variation in household income was not sufficient to account for this association. Rather, individual differences in human capital factors—educational attainment, cognitive ability, and self-control—predicted both credit scores and cardiovascular disease risk and accounted for ∼45% of the correlation between credit scores and cardiovascular disease risk. Tracing human capital factors back to their childhood antecedents revealed that the characteristic attitudes, behaviors, and competencies children develop in their first decade of life account for a significant portion (∼22%) of the link between credit scores and cardiovascular disease risk at midlife. We discuss the implications of these findings for policy debates about data privacy, financial literacy, and early childhood interventions.

  13. Animal Models of Cardiovascular Diseases

    Directory of Open Access Journals (Sweden)

    Carlos Zaragoza


    Full Text Available Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies. Several models have been developed to address cardiovascular complications, including atherothrombotic and cardiac diseases, and the same pathology have been successfully recreated in different species, including small and big animal models of disease. However, genetic and environmental factors play a significant role in cardiovascular pathophysiology, making difficult to match a particular disease, with a single experimental model. Therefore, no exclusive method perfectly recreates the human complication, and depending on the model, additional considerations of cost, infrastructure, and the requirement for specialized personnel, should also have in mind. Considering all these facts, and depending on the budgets available, models should be selected that best reproduce the disease being investigated. Here we will describe models of atherothrombotic diseases, including expanding and occlusive animal models, as well as models of heart failure. Given the wide range of models available, today it is possible to devise the best strategy, which may help us to find more efficient and reliable solutions against human cardiovascular diseases.

  14. Down Syndrome: A Cardiovascular Perspective (United States)

    Vis, J. C.; Duffels, M. G. J.; Winter, M. M.; Weijerman, M. E.; Cobben, J. M.; Huisman, S. A.; Mulder, B. J. M.


    This review focuses on the heart and vascular system in patients with Down syndrome. A clear knowledge on the wide spectrum of various abnormalities associated with this syndrome is essential for skillful management of cardiac problems in patients with Down syndrome. Epidemiology of congenital heart defects, cardiovascular aspects and…

  15. Iron deficiency and cardiovascular disease

    NARCIS (Netherlands)

    von Haehling, Stephan; Jankowska, Ewa A.; van Veldhuisen, Dirk J.; Ponikowski, Piotr; Anker, Stefan D.


    Iron deficiency affects up to one-third of the world's population, and is particularly common in elderly individuals and those with certain chronic diseases. Iron excess can be detrimental in cardiovascular illness, and research has now also brought anaemia and iron deficiency into the focus of card

  16. Hedgehog morphogen in cardiovascular disease

    NARCIS (Netherlands)

    Bijlsma, Maarten F.; Peppelenbosch, Maikel P.; Spek, C. Arnold


    In this review, we focus on the basic biology of the important developmental Hedgehog ( Hh) protein family, its general function in development, pathway mechanisms, and gene discovery and nomenclature. Hh function in cardiovascular development and recent findings concerning Hh signaling in ischemia

  17. Cardiovascular physiology at high altitude. (United States)

    Hooper, T; Mellor, A


    The role of the cardiovascular system is to deliver oxygenated blood to the tissues and remove metabolic effluent. It is clear that this complex system will have to adapt to maintain oxygen deliver in the profound hypoxia of high altitude. The literature on the adaptation of both the systemic and pulmonary circulations to high altitude is reviewed.

  18. The cardiovascular effects of methylxanthines

    NARCIS (Netherlands)

    Riksen, N.P.; Smits, P.; Rongen, G.A.P.J.M.


    In the concentration range that is normally achieved in humans, e.g., after the drinking of coffee or in patients treated with theophylline, the cardiovascular effects of methylxanthines are primarily due to antagonism of adenosine A(1) and A(2) receptors. Inhibition of phosphodiesterases or mobiliz

  19. Cardiovascular risk factors in men

    DEFF Research Database (Denmark)

    Gyllenborg, J; Rasmussen, S L; Borch-Johnsen, Knut;


    Males have higher risk of cardiovascular disease (CVD) than premenopausal females. Gonadal steroids are probably involved in the gender difference in CVD, but previous results have been conflicting. We investigated the associations between CVD risk factors and sex hormones in a cross...

  20. Serotonin receptors as cardiovascular targets

    NARCIS (Netherlands)

    C.M. Villalón (Carlos); P.A.M. de Vries (Peter); P.R. Saxena (Pramod Ranjan)


    textabstractSerotonin exerts complex effects in the cardiovascular system, including hypotension or hypertension, vasodilatation or vasoconstriction, and/or bradycardia or tachycardia; the eventual response depends primarily on the nature of the 5-HT receptors involved. In the light of current 5-HT

  1. Comparative cardiovascular safety of dementia medications

    DEFF Research Database (Denmark)

    Fosbøl, Emil L; Peterson, Eric D; Holm, Ellen


    To compare the cardiovascular safety of currently marketed dementia medications in new users in the United States and Denmark.......To compare the cardiovascular safety of currently marketed dementia medications in new users in the United States and Denmark....

  2. Induced Pluripotent Stem Cells in Cardiovascular Medicine

    Directory of Open Access Journals (Sweden)

    Toru Egashira


    Full Text Available Induced pluripotent stem (iPS cells are generated by reprogramming human somatic cells through the forced expression of several embryonic stem (ES cell-specific transcription factors. The potential of iPS cells is having a significant impact on regenerative medicine, with the promise of infinite self-renewal, differentiation into multiple cell types, and no problems concerning ethics or immunological rejection. Human iPS cells are currently generated by transgene introduction principally through viral vectors, which integrate into host genomes, although the associated risk of tumorigenesis is driving research into nonintegration methods. Techniques for pluripotent stem cell differentiation and purification to yield cardiomyocytes are also advancing constantly. Although there remain some unsolved problems, cardiomyocyte transplantation may be a reality in the future. After those problems will be solved, applications of human iPS cells in human cardiovascular regenerative medicine will be envisaged for the future. Furthermore, iPS cell technology has generated new human disease models using disease-specific cells. This paper summarizes the progress of iPS cell technology in cardiovascular research.

  3. Anabolic steroids and cardiovascular risk. (United States)

    Angell, Peter; Chester, Neil; Green, Danny; Somauroo, John; Whyte, Greg; George, Keith


    Recent reports from needle exchange programmes and other public health initiatives have suggested growing use of anabolic steroids (AS) in the UK and other countries. Data indicate that AS use is not confined to body-builders or high-level sportsmen. Use has spread to professionals working in emergency services, casual fitness enthusiasts and subelite sportsmen and women. Although the precise health consequences of AS use is largely undefined, AS use represents a growing public health concern. Data regarding the consequences of AS use on cardiovascular health are limited to case studies and a modest number of small cohort studies. Numerous case studies have linked AS use with a variety of cardiovascular disease (CVD) events or endpoints, including myocardial infarction, stroke and death. Large-scale epidemiological studies to support these links are absent. Consequently, the impact of AS use upon known CVD risk factors has been studied in relatively small, case-series studies. Data relating AS use to elevated blood pressure, altered lipid profiles and ECG abnormalities have been reported, but are often limited in scope, and other studies have often produced equivocal outcomes. The use of AS has been linked to the appearance of concentric left ventricular hypertrophy as well as endothelial dysfunction but the data again remains controversial. The mechanisms responsible for the negative effect of AS on cardiovascular health are poorly understood, especially in humans. Possibilities include direct effects on myocytes and endothelial cells, reduced intracellular Ca2+ levels, increased release of apoptogenic factors, as well as increased collagen crosslinks between myocytes. New data relating AS use to cardiovascular health risks are emerging, as novel technologies are developed (especially in non-invasive imaging) that can assess physiological structure and function. Continued efforts to fully document the cardiovascular health consequences of AS use is important to

  4. Sex steroids and cardiovascular disease

    Directory of Open Access Journals (Sweden)

    Bu Beng Yeap


    Full Text Available As men grow older, testosterone (T levels decline and the significance of this change is debated. The evidence supporting a causal role for lower circulating T, or its metabolites dihydrotestosterone (DHT and estradiol, in the genesis of atherosclerosis and cardiovascular disease (CVD in men is limited. Observational studies associate low baseline T levels with carotid atherosclerosis, aortic and peripheral vascular disease, and with the incidence of cardiovascular events and mortality. Studies using mass spectrometry suggest that when total T is assayed optimally, calculation of free T might not necessarily improve risk stratification. There is limited evidence to support an association of estradiol with CVD. Interventional studies of T therapy in men with coronary artery disease have shown beneficial effects on exercise-induced myocardial ischemia. However, placebo-controlled, randomized clinical trials (RCTs of T therapy in men with the prespecified outcomes of cardiovascular events or deaths are lacking. Meta-analyses of randomized controlled trials of T published up to 2010 found no increase in cardiovascular events, mortality, or prostate cancer with therapy. Recently, in a trial of older men with mobility limitations, men randomized to receive a substantial dose of T reported cardiovascular adverse effects. This phenomenon was not reported from a comparable trial where men received a more conservative dose of T, suggesting a prudent approach should be adopted when considering therapy in frail older men with existing CVD. Adequately powered RCTs of T in middle-aged and older men are needed to clarify whether or not hormonal intervention would reduce the incidence of CVD.

  5. Modelos experimentales de enfermedad cardiovascular Experimental models of cardiovascular disease

    Directory of Open Access Journals (Sweden)

    A. Gil Hernández


    Full Text Available El presente trabajo describe los modelos experimentales de utilidad clínica en el estudio de las enfermedades cardiovasculares y hace énfasis en los modelos usados para determinar los mecanismos fisiopatológicos de la aterosclerosis, así como para evaluar los efectos de productos nutricionales y farmacológicos sobre el desarrollo de este proceso inflamatorio complejo común a muchas enfermedades cardiovasculares. Se revisan los modelos animales en los que se puede inducir aterosclerosis por cambios en la composición de la dieta y los modelos animales en los que la alteración de uno o más genes (animales knock-out y knock-in, o la incorporación de genes foráneos de otras especies, da lugar a la aparición de hiperlipidemia con riesgo asociado de aparición de enfermedad cardiovascular temprana. Por otra parte, se consideran algunas de las líneas celulares más utilizadas en el estudio de los mecanismos moleculares de la aterogénesis y de evaluación de sustancias con interés nutricional o farmacológico.The present work describes clinically useful experimental models for the study of cardiovascular disease and emphasites the models used to determine the pathophysiologic mechanisms of atherosclerosis, as well as to evaluate the effects of nutritional and pharmacological products on the development of this complex inflammatory process present in many cardiovascular diseases. Animal models in which ahterosclerosis may be induced by dietary changes are reviewed, as well as those in which modification in one or more genes (knock-out and knock-in animals, or the incorporation of foreign genes from other species lead to early cardiovascular disease. On the other hand, some of the cell lines most frequently used in studying molecular mechanisms of atherosclerosis and assessment of substances with nutritional or pharmacological interest are considered.

  6. The nature of inherent bactericidal activity: insights from the nanotopology of three species of dragonfly (United States)

    Mainwaring, David E.; Nguyen, Song Ha; Webb, Hayden; Jakubov, Timur; Tobin, Mark; Lamb, Robert N.; Wu, Alex H.-F.; Marchant, Richard; Crawford, Russell J.; Ivanova, Elena P.


    While insect wings are widely recognised as multi-functional, recent work showed that this extends to extensive bactericidal activity brought about by cell deformation and lysis on the wing nanotopology. We now quantitatively show that subtle changes to this topography result in substantial changes in bactericidal activity that are able to span an order of magnitude. Notably, the chemical composition of the lipid nanopillars was seen by XPS and synchrotron FTIR microspectroscopy to be similar across these activity differences. Modelling the interaction between bacterial cells and the wing surface lipids of 3 species of dragonflies, that inhabit similar environments, but with distinctly different behavioural repertoires, provided the relationship between surface structure and antibacterial functionality. In doing so, these principal behavioural patterns correlated with the demands for antimicrobial efficiency dictated by differences in their foraging strategies. This work now reveals a new feature in the design elegance of natural multi-functional surfaces as well providing insights into the bactericidal mechanism underlying inherently antimicrobial materials, while suggesting that nanotopology is related to the evolutionary development of a species through the demands of its behavioural repertoire. The underlying relationship between the processes of wetting, adhesion and capillarity of the lipid nanopillars and bactericidal efficiency suggests new prospects for purely mechano-responsive antibacterial surfaces.While insect wings are widely recognised as multi-functional, recent work showed that this extends to extensive bactericidal activity brought about by cell deformation and lysis on the wing nanotopology. We now quantitatively show that subtle changes to this topography result in substantial changes in bactericidal activity that are able to span an order of magnitude. Notably, the chemical composition of the lipid nanopillars was seen by XPS and synchrotron

  7. Pregnancy disorders and cardiovascular disease risk

    NARCIS (Netherlands)

    Heida, K.Y.


    Cardiovascular disease is the most important cause of death in women in the Netherlands. Early identification of women at increased risk of cardiovascular disease and subsequent detection and treatment of risk factors contributes to the reduction of cardiovascular disease morbidity and mortality. A

  8. Mortality of mothers from cardiovascular and non-cardiovascular causes following pregnancy complications in first delivery

    DEFF Research Database (Denmark)

    Lykke, Jacob Alexander; Langhoff-Roos, Jens; Lockwood, Charles J;


    The combined effects of preterm delivery, small-for-gestational-age offspring, hypertensive disorders of pregnancy, placental abruption and stillbirth on early maternal death from cardiovascular causes have not previously been described in a large cohort. We investigated the effects of pregnancy...... cardiovascular and non-cardiovascular causes following preterm delivery, small-for-gestational-age offspring and hypertensive disorders of pregnancy. We found that preterm delivery and small-for-gestational-age were both associated with subsequent death of mothers from cardiovascular and non...... cardiovascular and non-cardiovascular causes, while hypertensive disorders of pregnancy are markers of early death of mothers from cardiovascular causes....

  9. Distinct Short-Range Order Is Inherent to Small Amorphous Calcium Carbonate Clusters (<2 nm)

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Shengtong [Physical Chemistry, University of Konstanz, Universitätsstrasse 10 78457 Konstanz Germany; School of Chemical Engineering, State Key Laboratory of Chemical Engineering, Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, East China University of Science and Technology, 130 Meilong Road Shanghai 200237 P.R. China; Chevrier, Daniel M. [Department of Chemistry and Institute for Research in Materials, Dalhousie University, Halifax Nova Scotia B3H 4R2 Canada; Zhang, Peng [Department of Chemistry and Institute for Research in Materials, Dalhousie University, Halifax Nova Scotia B3H 4R2 Canada; Gebauer, Denis [Physical Chemistry, University of Konstanz, Universitätsstrasse 10 78457 Konstanz Germany; Cölfen, Helmut [Physical Chemistry, University of Konstanz, Universitätsstrasse 10 78457 Konstanz Germany


    Amorphous intermediate phases are vital precursors in the crystallization of many biogenic minerals. While inherent short-range orders have been found in amorphous calcium carbonates (ACCs) relating to different crystalline forms, it has never been clarified experimentally whether such orders already exist in very small clusters less than 2 nm in size. Here, we studied the stability and structure of 10,12-pentacosadiynoic acid (PCDA) protected ACC clusters with a core size of ca. 1.4 nm consisting of only seven CaCO3 units. Ligand concentration and structure are shown to be key factors in stabilizing the ACC clusters. More importantly, even in such small CaCO3 entities, a proto-calcite short-range order can be identified but with a relatively high degree of disorder that arises from the very small size of the CaCO3 core. Our findings support the notion of a structural link between prenucleation clusters, amorphous intermediates, and final crystalline polymorphs, which appears central to the understanding of polymorph selection.

  10. Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism.

    Directory of Open Access Journals (Sweden)

    Huaiyu Yang


    Full Text Available The acid-sensing ion channel 1 (ASIC1 is a key receptor for extracellular protons. Although numerous structural and functional studies have been performed on this channel, the structural dynamics underlying the gating mechanism remains unknown. We used normal mode analysis, mutagenesis, and electrophysiological methods to explore the relationship between the inherent dynamics of ASIC1 and its gating mechanism. Here we show that a series of collective motions among the domains and subdomains of ASIC1 correlate with its acid-sensing function. The normal mode analysis result reveals that the intrinsic rotation of the extracellular domain and the collective motions between the thumb and finger induced by proton binding drive the receptor to experience a deformation from the extracellular domain to the transmembrane domain, triggering the channel pore to undergo "twist-to-open" motions. The movements in the transmembrane domain indicate that the likely position of the channel gate is around Leu440. These motion modes are compatible with a wide body of our complementary mutations and electrophysiological data. This study provides the dynamic fundamentals of ASIC1 gating.

  11. Bionic Ears: Their Development and Future Advances Using Neurotrophins and Inherently Conducting Polymers

    Directory of Open Access Journals (Sweden)

    Graeme M. Clark


    Full Text Available The development of the multiple-channel bionic ear for hearing and speech understanding in profoundly deaf people is the result of integrating biological and physical sciences with engineering. It is the first clinically successful restoration of sensory and brain function, and brings electronic technology into a direct functional relationship with human consciousness. It presently transmits essential place and coarse temporal information for the coding of frequency, but the fine temporal and place excitation of groups of nerve fibres is inadequate for high-fidelity sound. This is required for adequate musical appreciation and hearing in noise. Research has demonstrated that nerve growth factors preserve the peripheral processes of the auditory nerves so that an electrode array placed close to these fibres could produce this fine temporal and spatial coding. The nerve growth factors can be incorporated into inherently conducting polymers that are part of the array so the peripheral processes can be preserved at the same time as they are electrically stimulated.

  12. An analytic framework for developing inherently-manufacturable pop-up laminate devices (United States)

    Aukes, Daniel M.; Goldberg, Benjamin; Cutkosky, Mark R.; Wood, Robert J.


    Spurred by advances in manufacturing technologies developed around layered manufacturing technologies such as PC-MEMS, SCM, and printable robotics, we propose a new analytic framework for capturing the geometry of folded composite laminate devices and the mechanical processes used to manufacture them. These processes can be represented by combining a small set of geometric operations which are general enough to encompass many different manufacturing paradigms. Furthermore, such a formulation permits one to construct a variety of geometric tools which can be used to analyze common manufacturability concepts, such as tool access, part removability, and device support. In order to increase the speed of development, reduce the occurrence of manufacturing problems inherent with current design methods, and reduce the level of expertise required to develop new devices, the framework has been implemented in a new design tool called popupCAD, which is suited for the design and development of complex folded laminate devices. We conclude with a demonstration of utility of the tools by creating a folded leg mechanism.

  13. Widespread protein aggregation as an inherent part of aging in C. elegans.

    Directory of Open Access Journals (Sweden)

    Della C David

    Full Text Available Aberrant protein aggregation is a hallmark of many age-related diseases, yet little is known about whether proteins aggregate with age in a non-disease setting. Using a systematic proteomics approach, we identified several hundred proteins that become more insoluble with age in the multicellular organism Caenorhabditis elegans. These proteins are predicted to be significantly enriched in beta-sheets, which promote disease protein aggregation. Strikingly, these insoluble proteins are highly over-represented in aggregates found in human neurodegeneration. We examined several of these proteins in vivo and confirmed their propensity to aggregate with age. Different proteins aggregated in different tissues and cellular compartments. Protein insolubility and aggregation were significantly delayed or even halted by reduced insulin/IGF-1-signaling, which also slows aging. We found a significant overlap between proteins that become insoluble and proteins that influence lifespan and/or polyglutamine-repeat aggregation. Moreover, overexpressing one aggregating protein enhanced polyglutamine-repeat pathology. Together our findings indicate that widespread protein insolubility and aggregation is an inherent part of aging and that it may influence both lifespan and neurodegenerative disease.

  14. Rapid synthesis of inherently robust and stable superhydrophobic carbon soot coatings (United States)

    Esmeryan, Karekin D.; Castano, Carlos E.; Bressler, Ashton H.; Abolghasemibizaki, Mehran; Mohammadi, Reza


    The fabrication of superhydrophobic coatings using a candle flame or rapeseed oil has become very attractive as a novel approach for synthesis of water repellent surfaces. Here, we report an improved, simplified and time-efficient method for the preparation of robust superhydrophobic carbon soot that does not require any additional stabilizers or chemical treatment. The soot's inherent stabilization is achieved using a specially-designed cone-shaped aluminum chimney, mounted over an ignited paper-based wick immersed in a rapeseed oil. Such configuration decreases the level of oxygen during the process of combustion; altering the ratio of chemical bonds in the soot. As a result, the fractal-like network of the carbon nanoparticles is converted into dense and fused carbon chains, rigidly coupled to the substrate surface. The modified carbon coating shows thermal sustainability and retains superhydrophobicity up to ∼300 °C. Furthermore, it demonstrates a low contact angle hysteresis of 0.7-1.2° accompanied by enhanced surface adhesion and mechanical durability under random water flows. In addition, the soot's deposition rate of ∼1.5 μm/s reduces the exposure time of the substrate to heat and consequently minimizes the thermal effects, allowing the creation of superhydrophobic coatings on materials with low thermal stability (e.g. wood or polyethylene).

  15. Laser Chemosensor with Rapid Responsivity and Inherent Memory Based on a Polymer of Intrinsic Microporosity

    Directory of Open Access Journals (Sweden)

    Graham A. Turnbull


    Full Text Available This work explores the use of a polymer of intrinsic microporosity (PIM-1 as the active layer within a laser sensor to detect nitroaromatic-based explosive vapors. We show successful detection of dinitrobenzene (DNB by monitoring the real-time photoluminescence. We also show that PIM-1 has an inherent memory, so that it accumulates the analyte during exposure. In addition, the optical gain and refractive index of the polymer were studied by amplified spontaneous emission and variable-angle ellipsometry, respectively. A second-order distributed feedback PIM-1 laser sensor was fabricated and found to show an increase in laser threshold of 2.5 times and a reduction of the laser slope efficiency by 4.4 times after a 5-min exposure to the DNB vapor. For pumping at 2 times threshold, the lasing action was stopped within 30 s indicating that PIM-1 has a very fast responsivity and as such has a potential sensing ability for ultra-low-concentration explosives.

  16. Analytical Study on Inherent Properties of a Unidirectional Vibrating Steel Strip Partially Immersed in Fluid

    Directory of Open Access Journals (Sweden)

    J. Li


    Full Text Available The theory of singuarity functions is introduced to present an analytical approach for the natural properties of a unidirectional vibrating steel strip with two opposite edges simply supported and other two free, partially submerged in fluid and under tension. The velocity potential and Bernoulli's equation are used to describe the fluid pressure acting on the steel strip. The effect of fluid on vibrations of the strip may be equivalent to added mass of the strip. The math formula of added mass can be obtained from kinematic boundary conditions of the strip-fluid interfaces. Singularity functions are adopted to solve problems of the strip with discontinuous characteristics. By applying Laplace transforms, analytical solutions for inherent properties of the vibrating steel strip in contact with fluid are finally acquired. An example is given to illustrate that the proposed method matches the numerical solution using the finite element method (FEM very closely. The results show that fluid has strong effect on natural frequencies and mode shapes of vibrating steel strips partially dipped into a liquid. The influences such as tension, the submergence depth, the position of strip in the container and the dimension of the container on the dynamic behavior of the strip are also investigated. Moreover, the presented method can also be used to study vertical or angled plates with discontinuous characteristics as well as different types of pressure fields around.

  17. Modeling the inherent optical properties of aquatic particles using an irregular hexahedral ensemble (United States)

    Xu, Guanglang; Sun, Bingqiang; Brooks, Sarah D.; Yang, Ping; Kattawar, George W.; Zhang, Xiaodong


    A statistical approach in defining particle morphology in terms of an ensemble of hexahedra of distorted shapes is employed for modeling the Inherent Optical Properties (IOPs) of aquatic particles. The approach is inspired by the rich variability in shapes of real aquatic particles that cannot be represented by one particular shape. Two methods, the Invariant Imbedding T-matrix (II-TM) and Physical Geometric Optics Hybrid (PGOH) method, are combined to simulate the IOPs for aquatic particles of sizes ranging from the Rayleigh scattering to geometric optics regimes. Nonspherical effects on the IOPs are examined by comparing the results with predictions based on the Lorenz-Mie theory to explore the limitations of assuming the particles to be spherical. We pay special attention to backscattering-related and polarimetric scattering properties, particularly the backscattering ratio, Gordon parameter, backscattering volume scattering function and the degree of linear polarization. The simulated IOPs are compared with the in-situ measurements to assess the feasibility of using a hexahedral ensemble in modeling the IOPs of the aquatic particles.

  18. Cometabolic degradation of organic wastewater micropollutants by activated sludge and sludge-inherent microorganisms. (United States)

    Fischer, Klaus; Majewsky, Marius


    Municipal wastewaters contain a multitude of organic trace pollutants. Often, their biodegradability by activated sludge microorganisms is decisive for their elimination during wastewater treatment. Since the amounts of micropollutants seem too low to serve as growth substrate, cometabolism is supposed to be the dominating biodegradation process. Nevertheless, as many biodegradation studies were performed without the intention to discriminate between metabolic and cometabolic processes, the specific contribution of the latter to substance transformations is often not clarified. This minireview summarizes current knowledge about the cometabolic degradation of organic trace pollutants by activated sludge and sludge-inherent microorganisms. Due to their relevance for communal wastewater contamination, the focus is laid on pharmaceuticals, personal care products, antibiotics, estrogens, and nonylphenols. Wherever possible, reference is made to the molecular process level, i.e., cometabolic pathways, involved enzymes, and formed transformation products. Particular cometabolic capabilities of different activated sludge consortia and various microbial species are highlighted. Process conditions favoring cometabolic activities are emphasized. Finally, knowledge gaps are identified, and research perspectives are outlined.

  19. Bayesian estimation inherent in a Mexican-hat-type neural network (United States)

    Takiyama, Ken


    Brain functions, such as perception, motor control and learning, and decision making, have been explained based on a Bayesian framework, i.e., to decrease the effects of noise inherent in the human nervous system or external environment, our brain integrates sensory and a priori information in a Bayesian optimal manner. However, it remains unclear how Bayesian computations are implemented in the brain. Herein, I address this issue by analyzing a Mexican-hat-type neural network, which was used as a model of the visual cortex, motor cortex, and prefrontal cortex. I analytically demonstrate that the dynamics of an order parameter in the model corresponds exactly to a variational inference of a linear Gaussian state-space model, a Bayesian estimation, when the strength of recurrent synaptic connectivity is appropriately stronger than that of an external stimulus, a plausible condition in the brain. This exact correspondence can reveal the relationship between the parameters in the Bayesian estimation and those in the neural network, providing insight for understanding brain functions.

  20. Bayesian estimation inherent in a Mexican-hat-type neural network. (United States)

    Takiyama, Ken


    Brain functions, such as perception, motor control and learning, and decision making, have been explained based on a Bayesian framework, i.e., to decrease the effects of noise inherent in the human nervous system or external environment, our brain integrates sensory and a priori information in a Bayesian optimal manner. However, it remains unclear how Bayesian computations are implemented in the brain. Herein, I address this issue by analyzing a Mexican-hat-type neural network, which was used as a model of the visual cortex, motor cortex, and prefrontal cortex. I analytically demonstrate that the dynamics of an order parameter in the model corresponds exactly to a variational inference of a linear Gaussian state-space model, a Bayesian estimation, when the strength of recurrent synaptic connectivity is appropriately stronger than that of an external stimulus, a plausible condition in the brain. This exact correspondence can reveal the relationship between the parameters in the Bayesian estimation and those in the neural network, providing insight for understanding brain functions.

  1. Inherent rhythmcity and interstitial cells of Cajal in a frog vein

    Indian Academy of Sciences (India)

    Dipanwita Ghose; Lingu Jose; S Manjunatha; Muddanna S Rao; J Prakasa Rao


    Interstitial cells of Cajal are responsible for rhythmic contractions of the musculature of the gastrointestinal tract and blood vessels. The existence of these cells and spontaneous rhythmicity were noticed in amphibian vein and the findings are reported in this paper. The postcaval vein was identified in the frog, Rana tigrina and was perfused with amphibian Ringer solution after isolation. Contractile activity was recorded through a tension transducer connected to a polygraph. The isolated postcaval vein showed spontaneous rhythmic activity. Addition of cold Ringer solution decreased, while warm Ringer increased, the rate of contraction. Adrenaline caused inhibition of rhythmic activity at a dosage that increased the rate of isolated sinus venosus. Sections of the postcaval vein, when stained supravitally with methylene blue, showed the presence of interstitial cells of Cajal. Photic stimulation of the vein in the presence of methylene blue led to a significant decrease in the rate of spontaneous beating of the vein. These findings indicate that the postcaval vein of frog is capable of inherent rhythmcity, which is dependent on the interstitial cells of Cajal but is independent of the sinus venosus.

  2. Mapping of Total Suspended Solid from Inherent Optical Properties using Optical Model (United States)

    Syahreza, S.; Beh, B. C.; Lim, H. S.; MatJafri, M. Z.; Abdullah, K.


    Environmental monitoring through the method of traditional ship sampling is time consuming and requires a high survey cost. An investigation has been conducted to test the feasibility of using OceanSat-2 for estimating Total Suspended Solid (TSS) in the coastal waters of Penang Island, Malaysia. The proposed algorithm is based on the reflectance model that is a function of the inherent optical properties of water, which can be related to its constituent's concentrations. Water samples were collected simultaneously with the satellite image acquisition and later analyzed in the laboratory. Water sample's locations were determined by using a handheld GPS. A simple atmospheric correction, namely darkest pixel technique was performed in this study. The pixel with the lowest value for each band was selected as the darkest pixel. The digital numbers for each band corresponding to the sea-truth locations were extracted and then converted into radiance values and reflectance values. The accuracies of algorithms was also investigated based on the observations of correlation coefficient (R) and root-mean-square deviations (RMS) with the sea-truth data. This algorithm was then used to map the TSS concentration over Penang, Malaysia. This study indicates that TSS mapping can be carried out using remote sensing technique of the satellite digital photography system over Penang, Malaysia.

  3. Inherent Structure-Based Multiview Learning With Multitemplate Feature Representation for Alzheimer's Disease Diagnosis. (United States)

    Liu, Mingxia; Zhang, Daoqiang; Adeli, Ehsan; Shen, Dinggang


    Multitemplate-based brain morphometric pattern analysis using magnetic resonance imaging has been recently proposed for automatic diagnosis of Alzheimer's disease (AD) and its prodromal stage (i.e., mild cognitive impairment or MCI). In such methods, multiview morphological patterns generated from multiple templates are used as feature representation for brain images. However, existing multitemplate-based methods often simply assume that each class is represented by a specific type of data distribution (i.e., a single cluster), while in reality, the underlying data distribution is actually not preknown. In this paper, we propose an inherent structure-based multiview leaning method using multiple templates for AD/MCI classification. Specifically, we first extract multiview feature representations for subjects using multiple selected templates and then cluster subjects within a specific class into several subclasses (i.e., clusters) in each view space. Then, we encode those subclasses with unique codes by considering both their original class information and their own distribution information, followed by a multitask feature selection model. Finally, we learn an ensemble of view-specific support vector machine classifiers based on their, respectively, selected features in each view and fuse their results to draw the final decision. Experimental results on the Alzheimer's Disease Neuroimaging Initiative database demonstrate that our method achieves promising results for AD/MCI classification, compared to the state-of-the-art multitemplate-based methods.

  4. Retrieving Marine Inherent Optical Properties from Satellites Using Temperature and Salinity-dependent Backscattering by Seawater (United States)

    Werdell, Paul J.; Franz, Bryan Alden; Lefler, Jason Travis; Robinson, Wayne D.; Boss, Emmanuel


    Time-series of marine inherent optical properties (IOPs) from ocean color satellite instruments provide valuable data records for studying long-term time changes in ocean ecosystems. Semi-analytical algorithms (SAAs) provide a common method for estimating IOPs from radiometric measurements of the marine light field. Most SAAs assign constant spectral values for seawater absorption and backscattering, assume spectral shape functions of the remaining constituent absorption and scattering components (e.g., phytoplankton, non-algal particles, and colored dissolved organic matter), and retrieve the magnitudes of each remaining constituent required to match the spectral distribution of measured radiances. Here, we explore the use of temperature- and salinity-dependent values for seawater backscattering in lieu of the constant spectrum currently employed by most SAAs. Our results suggest that use of temperature- and salinity-dependent seawater spectra elevate the SAA-derived particle backscattering, reduce the non-algal particles plus colored dissolved organic matter absorption, and leave the derived absorption by phytoplankton unchanged.

  5. Entropy: An Inherent, Non-statistical Property of any System in any State

    Directory of Open Access Journals (Sweden)

    Elias P. Gyftopoulos


    Full Text Available

    Entropy is the distinguishing and most important concept of our efforts to understand and regularize our observations of a very large class of natural phenomena, and yet, it is one of the most contentious concepts of physics. In this article, we review two expositions of thermodynamics, one without reference to quantum theory, and the other quantum mechanical without probabilities of statistical mechanics. In the first, we show that entropy is an inherent property of any system in any state, and that its analytical expression must conform to eight criteria. In the second, we recognize that quantum thermodynamics: (i admits quantum probabilities described either by wave functions or by nonstatistical density operators; and (ii requires a nonlinear equation of motion that is delimited by but more general than the Schrödinger equation, and that accounts for both reversible and irreversible evolutions of the state of the system in time. Both the more general quantum probabilities, and the equation of motion have been defined, and the three laws of thermodynamics are shown to be theorems of this equation.

    • An initial version of this paper was published in
      July of 2006 in the proceedings of ECOS’06, Aghia
      Pelagia, Crete, Greece. 

  6. Simple frequency-dependent tools for analysis of inherent control limitations

    Directory of Open Access Journals (Sweden)

    Sigurd Skogestad


    Full Text Available By a plant's inherent control limitations we mean the characteristics of the plant which will cause poor control performance irrespective of what controller is used. Another frequently used term is 'dynamic resilience' which is the best closed-loop performance achievable using any controller. Since a plant's dynamic resilience cannot be altered by change of the control algorithm, but only by design modifications, it follows that the term controllability provides a link between process design and process control. In this paper we focus on two aspects of controllability. The plants' sensitivity to disturbances and the limitations imposed by interactions when using decentralized control. We use simple tools such as the RGA, the PRGA (Performance RGA and the closely related Closed Loop Disturbance Gain (CLDG. For example, if kth column of the CLDG is large, then this indicates that disturbance k will be difficult to reject. This may pinpoint the need for modifying the process. The PRGA provides a measure of interaction which also includes one-way coupling. In the paper we apply these measures to distillation column control and fluid catalytic cracker (FCC control.

  7. The nature of inherent bactericidal activity: insights from the nanotopology of three species of dragonfly. (United States)

    Mainwaring, David E; Nguyen, Song Ha; Webb, Hayden; Jakubov, Timur; Tobin, Mark; Lamb, Robert N; Wu, Alex H-F; Marchant, Richard; Crawford, Russell J; Ivanova, Elena P


    While insect wings are widely recognised as multi-functional, recent work showed that this extends to extensive bactericidal activity brought about by cell deformation and lysis on the wing nanotopology. We now quantitatively show that subtle changes to this topography result in substantial changes in bactericidal activity that are able to span an order of magnitude. Notably, the chemical composition of the lipid nanopillars was seen by XPS and synchrotron FTIR microspectroscopy to be similar across these activity differences. Modelling the interaction between bacterial cells and the wing surface lipids of 3 species of dragonflies, that inhabit similar environments, but with distinctly different behavioural repertoires, provided the relationship between surface structure and antibacterial functionality. In doing so, these principal behavioural patterns correlated with the demands for antimicrobial efficiency dictated by differences in their foraging strategies. This work now reveals a new feature in the design elegance of natural multi-functional surfaces as well providing insights into the bactericidal mechanism underlying inherently antimicrobial materials, while suggesting that nanotopology is related to the evolutionary development of a species through the demands of its behavioural repertoire. The underlying relationship between the processes of wetting, adhesion and capillarity of the lipid nanopillars and bactericidal efficiency suggests new prospects for purely mechano-responsive antibacterial surfaces.

  8. The endothelium - the cardiovascular health barometer. (United States)

    Herrmann, Joerg; Lerman, Amir


    Once considered to fulfill no other purpose than that of a physical barrier between blood and tissue, the multifunctional nature of the endothelium was discovered in the later half of the 20th century. In cardiology, the dysfunctional nature of the endothelium has received even more attention, initially mainly within the research community but later also in the clinical community, serving as a prime example for the translation of bench research to patient care. In this review, the entity of endothelial dysfunction, its modes of diagnosis in clinical practice, its prognostic implications, and its treatment options will be defined. From past conceptual ideas to current practical applications to the road ahead, the endothelium is to be viewed as the cardiovascular health barometer.

  9. Cardiovascular risk, effectiveness and mortality

    Directory of Open Access Journals (Sweden)

    Juan Gérvas


    Full Text Available Dice la Ley de Hierro de la Epidemiología que todo el que nace muere. Por ello el fin de la Medicina no es evitar la muerte en sí, sino evitar las muertes, las enfermedades y el sufrimiento médicamente evitables.Al final, todos nuestros pacientes morirán – y nosotros mismos moriremos también, obviamente. “Los cuerpos encuentran una forma de morir” y si la causa no es el hambre ni la deshidratación, ni es congénita, ni infecciosa, ni por lesiones, ni por cáncer, ni por suicidio, tenemos que esperar que sea por ‘causa cardiovascular’, enfermedad pulmonar, insuficiencia renal o hepática, demencia u otras enfermedades degenerativas. Pero de algo tenemos que morir.Morir por causa cardiovascular ni es deshonroso, ni implica defectuosa atención clínica. Que la primera causa de muerte sea la cardiovascular no dice nada respecto a los cuidados clínicos, ni debería asustar.Sin embargo, son evitables muchas muertes de causa cardiovascular. Así, se puede evitar mucha mortalidad cardiovascular disminuyendo la desigualdad social, por ejemplo (con mejor re-distribución de la riqueza, mejor educación y demás. Los médicos saben que los factores adversos psicosociales asociados a la pertenencia a la clase baja responden del 35% del riesgo atribuible a la hipertensión en la incidencia del infarto de miocardio (en otra formulación, que pertenecer a la clase baja multiplica por 2,7 dicho riesgo1.También deberíamos saber que contra las muertes cardiovasculares no hay nada como las políticas de salud pública sobre el tabaquismo (restricciones de lugares en los que fumar, aumento del precio del tabaco, campañas de información, y demás.En lo clínico, las muertes cardiovasculares evitables se deben ver en perspectiva, según lo que se puede lograr2. Así, por 100.000 habitantes y año, el tratamiento con inhibidores de la enzima convertidora de angiotensina (IECA en la insuficiencia cardíaca puede evitar 308 muertes; el consejo m

  10. Predicting welding distortion in a panel structure with longitudinal stiffeners using inherent deformations obtained by inverse analysis method. (United States)

    Liang, Wei; Murakawa, Hidekazu


    Welding-induced deformation not only negatively affects dimension accuracy but also degrades the performance of product. If welding deformation can be accurately predicted beforehand, the predictions will be helpful for finding effective methods to improve manufacturing accuracy. Till now, there are two kinds of finite element method (FEM) which can be used to simulate welding deformation. One is the thermal elastic plastic FEM and the other is elastic FEM based on inherent strain theory. The former only can be used to calculate welding deformation for small or medium scale welded structures due to the limitation of computing speed. On the other hand, the latter is an effective method to estimate the total welding distortion for large and complex welded structures even though it neglects the detailed welding process. When the elastic FEM is used to calculate the welding-induced deformation for a large structure, the inherent deformations in each typical joint should be obtained beforehand. In this paper, a new method based on inverse analysis was proposed to obtain the inherent deformations for weld joints. Through introducing the inherent deformations obtained by the proposed method into the elastic FEM based on inherent strain theory, we predicted the welding deformation of a panel structure with two longitudinal stiffeners. In addition, experiments were carried out to verify the simulation results.

  11. Predicting Welding Distortion in a Panel Structure with Longitudinal Stiffeners Using Inherent Deformations Obtained by Inverse Analysis Method

    Directory of Open Access Journals (Sweden)

    Wei Liang


    Full Text Available Welding-induced deformation not only negatively affects dimension accuracy but also degrades the performance of product. If welding deformation can be accurately predicted beforehand, the predictions will be helpful for finding effective methods to improve manufacturing accuracy. Till now, there are two kinds of finite element method (FEM which can be used to simulate welding deformation. One is the thermal elastic plastic FEM and the other is elastic FEM based on inherent strain theory. The former only can be used to calculate welding deformation for small or medium scale welded structures due to the limitation of computing speed. On the other hand, the latter is an effective method to estimate the total welding distortion for large and complex welded structures even though it neglects the detailed welding process. When the elastic FEM is used to calculate the welding-induced deformation for a large structure, the inherent deformations in each typical joint should be obtained beforehand. In this paper, a new method based on inverse analysis was proposed to obtain the inherent deformations for weld joints. Through introducing the inherent deformations obtained by the proposed method into the elastic FEM based on inherent strain theory, we predicted the welding deformation of a panel structure with two longitudinal stiffeners. In addition, experiments were carried out to verify the simulation results.

  12. Cardiovascular Prevention of Cognitive Decline

    Directory of Open Access Journals (Sweden)

    Jean-Jacques Monsuez


    Full Text Available Midlife cardiovascular risk factors, including diabetes, hypertension, dyslipemia, and an unhealthy lifestyle, have been linked to subsequent incidence, delay of onset, and progression rate of Alzheimer disease and vascular dementia. Conversely, optimal treatment of cardiovascular risk factors prevents and slows down age-related cognitive disorders. The impact of antihypertensive therapy on cognitive outcome in patients with hypertension was assessed in large trials which demonstrated a reduction in progression of MRI white matter hyperintensities, in cognitive decline and in incidence of dementia. Large-scale database correlated statin use and reduction in the incidence of dementia, mainly in patients with documented atherosclerosis, but clinical trials failed to reach similar conclusions. Whether a multitargeted intervention would substantially improve protection, quality of life, and reduce medical cost expenditures in patients with lower risk profile has not been ascertained. This would require appropriately designed trials targeting large populations and focusing on cognitive decline as a primary outcome endpoint.

  13. Chiral cardiovascular drugs: an overview. (United States)

    Ranade, Vasant V; Somberg, John C


    Stereochemistry in drug molecules is rapidly becoming an important aspect in drug research, design, and development. Recently, individual stereoisomers of drug molecules with asymmetric centers such as fexofenadine, cetirizine, verapamil, fluoxetine, levalbutarol, and amphetamine, for example, have been separated and developed as individual drugs. These stereoisomers have different therapeutic activity, and each isomer has contributed differently with respect to its formulation's pharmacologic activity, side effects, and toxicity. The present overview discusses chirality among a select group of cardiovascular drugs, their stereochemical synthesis/preparation, isolation techniques using chiral chromatography, methods for confirmation of their enantiomeric purity, pharmacodynamics, and pharmacokinetics. Chirality has been visualized as an important factor in cardiovascular research. It is also becoming evident in other areas of therapeutics.

  14. Educational differences in cardiovascular mortality

    DEFF Research Database (Denmark)

    Kjøllesdal, M. K. R.; Ariansen, I.; Mortensen, L. H.;


    Aims: To explore the confounding effects of early family factors shared by siblings and cardiovascular risk factors in midlife on the educational differences in mortality from cardiovascular disease (CVD). Methods: Data from national and regional health surveys in Norway (1974–2003) were linked...... with data from the Norwegian Family Based Life Course Study, the National Educational Registry and the Cause of Death Registry. The study population consisted of participants with at least one full sibling among the health survey participants (n=271,310). Data were available on CVD risk factors, including...... weight, height, blood pressure, total cholesterol and smoking. Results: The hazards ratio (HR) of CVD mortality was 3.44 (95% confidence interval (CI) 2.98–3.96) in the lowest educational group relative to the highest. The HRs were little altered in the within-sibship analyses. Adjusted for risk factors...

  15. Cardiovascular stress of photochemotherapy (PUVA)

    Energy Technology Data Exchange (ETDEWEB)

    Ciafone, R.A.; Rhodes, A.R.; Audley, M.; Freedberg, I.M.; Abelmann, W.H.


    The recently devised therapy for psoriasis and related skin diseases, consisting of long-wave ultraviolet light and oral 8-methoxypsoralen (PUVA), was investigated for its cardiovascular effects. In seventeen patients, long-wave ultraviolet light therapy in a treatment enclosure (mean duration, 19.3 minutes) resulted in ambient temperatures of 39.2 degrees C +/- 2.1 degrees C (SD) and skin temperatures of 38.2 degrees C +/- 1.4 degrees C. In upright subjects, heart rate rose 30.8% to 114.4 +/- 25.2 beats per minute (bpm). Intensive room air conditioning, outside of the treatment enclosure, although significantly lowering skin and ambient temperatures, did not affect the heart rates significantly. PUVA therapy is associated with a definite cardiovascular stress when the box type of therapeutic unit is used. Possible modifications are discussed.

  16. Cardiovascular disease incidence and survival

    DEFF Research Database (Denmark)

    Byberg, Stine; Agyemang, Charles; Zwisler, Ann Dorthe


    Studies on cardiovascular disease (CVD) incidence and survival show varying results between different ethnic groups. Our aim was to add a new dimension by exploring the role of migrant status in combination with ethnic background on incidence of-and survival from-CVD and more specifically acute...... significantly lower incidence of CVD, AMI and stroke. All-cause and cause-specific survival after CVD, AMI and stroke was similar or significantly better for migrants compared to Danish-born, regardless of type of migrant (refugee vs. family-reunified) or country of origin. Refugees are disadvantaged in terms...... of some types of cardiovascular disease compared to Danish-born. Family-reunified migrants on the other hand had lower rates of CVD. All migrants had better survival than Danish-born indicating that migrants may not always be disadvantaged in health....

  17. Polyphenols, Inflammation, and Cardiovascular Disease


    Tangney, Christy; Rasmussen, Heather E.


    Polyphenols are compounds found in foods such as tea, coffee, cocoa, olive oil, and red wine and have been studied to determine if their intake may modify cardiovascular disease (CVD) risk. Historically, biologic actions of polyphenols have been attributed to antioxidant activities, but recent evidence suggests that immunomodulatory and vasodilatory properties of polyphenols may also contribute to CVD risk reduction. These properties will be discussed, and recent epidemiological evidence and ...

  18. Cocoa, chocolate and cardiovascular disease


    Galleano, Monica; Oteiza, Patricia I.; Fraga, Cesar G.


    A significant body of evidence demonstrates that diets rich in fruit and vegetables promote health, and attenuate, or delay, the onset of various diseases, including cardiovascular disease (CVD), diabetes, certain cancers, and several other age-related degenerative disorders. The concept that moderate chocolate consumption could be part of a healthy diet has gained acceptance in the last years based on the health benefits ascribed to selected cocoa components. Specifically, cocoa as a plant a...

  19. Disparities in women's cardiovascular health. (United States)

    McSweeney, Jean C; Pettey, Christina M; Souder, Elaine; Rhoads, Sarah


    Cardiovascular disease (CVD) is the leading cause of death in women, and disparities affect the diagnosis, treatment, and outcomes of CVD for women. Biology, genetics, and race contribute to these disparities. Obstetric-gynecologic health care providers routinely encounter women who are at risk for developing CVD and are uniquely positioned as a point of access to intervene to improve/prevent CVD by assessing for risks and discussing healthy lifestyle changes during routine visits.

  20. Vitamin E and cardiovascular disease. (United States)

    Saremi, Adonis; Arora, Rohit


    The objective of this article is to review the role of vitamin E in cardiovascular disease. We begin by describing the general characteristics and metabolism of vitamin E and the pathogenesis of atherosclerosis as it relates to oxidation. We also discuss key in vitro studies, animal studies, observational studies, and clinical trials regarding the potentially cardioprotective effect of vitamin E. Lastly, we outline the current recommendations regarding vitamin E in the prevention and treatment of cardiovascular disease as stated by the American Heart Association. Vitamin E is a fat-soluble antioxidant vitamin and alpha-tocopherol is its most naturally abundant and active form. Oxidation is a key step in atherogenesis. Oxidized low-density lipoprotein stimulates endothelial cells to produce inflammatory markers, is involved in foam cell formation, has cytotoxic effects on endothelial cells, inhibits the motility of tissue macrophages, and inhibits nitric oxide-induced vasodilatation. Vitamin E has been shown to increase oxidative resistance in vitro and prevent atherosclerotic plaque formation in mouse models. Consumption of foods rich in vitamin E has been associated with lower risk of coronary heart disease in middle-aged to older men and women. Clinical studies at large have not demonstrated a benefit of vitamin E in the primary and secondary prevention of cardiovascular disease. Vitamin E supplementation might be associated with an increase in total mortality, heart failure, and hemorrhagic stroke. The American Heart Association does not support the use of vitamin E supplements to prevent cardiovascular disease, but does recommend the consumption of foods abundant in antioxidant vitamins and other nutrients.

  1. Coffee Consumption and Cardiovascular Health. (United States)

    Chrysant, Steven G


    Coffee is the most widely consumed beverage worldwide and is only second to water drinking and is consumed by 83% of adults in the United States. The long-held controversy regarding the association of coffee consumption with an increased incidence of cardiovascular diseases (CVDs) and hypertension has been reversed by several recent prospective cohort studies and meta-analyses, which have demonstrated that coffee consumption is not associated with increased incidence of CVDs and hypertension and instead it could have a beneficial effect. To get a better understanding of the effects of coffee consumption on cardiovascular health, a Medline search of the English language literature was conducted from 2010 to early 2015 and 25 pertinent reports with information on the effects of coffee drinking, the incidence of CVDs, and hypertension and its mechanism of action were selected for inclusion in this commentary. These studies have shown either a neutral or beneficial effect of coffee on cardiovascular health. In conclusion, coffee is safe to drink by both normal subjects and by those with preexisting CVDs and hypertension.

  2. Cocoa, chocolate, and cardiovascular disease. (United States)

    Galleano, Monica; Oteiza, Patricia I; Fraga, Cesar G


    A significant body of evidence demonstrates that diets rich in fruits and vegetables promote health and attenuate, or delay, the onset of various diseases, including cardiovascular disease, diabetes, certain cancers, and several other age-related degenerative disorders. The concept that moderate chocolate consumption could be part of a healthy diet has gained acceptance in past years based on the health benefits ascribed to selected cocoa components. Specifically, cocoa as a plant and chocolate as food contain a series of chemicals that can interact with cell and tissue components, providing protection against the development and amelioration of pathological conditions. The most relevant effects of cocoa and chocolate have been related to cardiovascular disease. The mechanisms behind these effects are still under investigation. However, the maintenance or restoration of vascular NO production and bioavailability and the antioxidant effects are the mechanisms most consistently supported by experimental data. This review will summarize the most recent research on the cardiovascular effects of cocoa flavanols and related compounds.

  3. Repurposing of approved cardiovascular drugs. (United States)

    Ishida, Junichi; Konishi, Masaaki; Ebner, Nicole; Springer, Jochen


    Research and development of new drugs requires both long time and high costs, whereas safety and tolerability profiles make the success rate of approval very low. Drug repurposing, applying known drugs and compounds to new indications, has been noted recently as a cost-effective and time-unconsuming way in developing new drugs, because they have already been proven safe in humans. In this review, we discuss drug repurposing of approved cardiovascular drugs, such as aspirin, beta-blockers, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, cardiac glycosides and statins. Regarding anti-tumor activities of these agents, a number of experimental studies have demonstrated promising pleiotropic properties, whereas all clinical trials have not shown expected results. In pathological conditions other than cancer, repurposing of cardiovascular drugs is also expanding. Numerous experimental studies have reported possibilities of drug repurposing in this field and some of them have been tried for new indications ('bench to bedside'), while unexpected results of clinical studies have given hints for drug repurposing and some unknown mechanisms of action have been demonstrated by experimental studies ('bedside to bench'). The future perspective of experimental and clinical studies using cardiovascular drugs are also discussed.

  4. Pseudoexfoliation syndrome and cardiovascular diseases

    Institute of Scientific and Technical Information of China (English)

    Georgios; K; Andrikopoulos; Dimitrios; K; Alexopoulos; Sotirios; P; Gartaganis


    Pseudoexfoliation(PEX) syndrome is a well-recognized late-onset disease caused by a generalized fibrillopathy. It is linked to a broad spectrum of ocular complications including glaucoma and perioperative problems during cataract surgery. Apart from the long-known intraocular manifestations, PEX deposits have been found in a variety of extraocular locations and they appear to represent a systemic process associated with increased cardiovascular and cerebrovascular morbidity. However, as published results are inconsistent, the clinical significance of the extraocular PEX deposits remains controversial. Identification of PEX deposits in the heart and the vessel wall, epidemiologic studies, as well as, similarities in pathogenetic mechanisms have led to the hypothesis of a possible relation between fibrillar material and cardiovascular disease. Recent studies suggest that PEX syndrome is frequently linked to impaired heart and blood vessels function. Systemic and ocular blood flow changes, altered parasympathetic vascular control and baroreflex sensitivity, increased vascular resistance and decreased blood flow velocity, arterial endothelial dysfunction, high levels of plasma homocysteine and arterial hypertension have all been demonstrated in PEX subjects. Common features in the pathogenesis of both atherosclerosis and PEX, like oxidative stress and inflammation and a possible higher frequency of abdominal aorta aneurysm in PEX patients, could imply that these grey-white deposits and cardiovascular disorders are related or reflect different manifestations of the same process.

  5. Air pollution and cardiovascular disease. (United States)

    Nogueira, J Braz


    Air pollution is associated with increased cardiovascular morbidity and mortality. Recent experimental and epidemiologic studies show that particulate matter (PM) air pollution with PM10 or inhalable (thoracic) particles (mean aerodynamic diameter particles (aerodynamic diameter biological mechanisms responsible for adverse cardiovascular outcomes associated with PM have been described, including the release of pro-oxidative and pro-inflammatory mediators from the lungs into the circulation, autonomic nervous system imbalance, and the direct actions on the heart and vasculature of ultrafine particles translocated into the systemic circulation. The induction of oxidative stress by these particles may be central to all of these putative pathways that trigger coagulation and thrombosis, increased heart rate and reduced heart rate variability, endothelial dysfunction, arterial vasoconstriction, apoptosis, and hypertension. In chronic exposures these alterations favor the development and progression of atherosclerosis and possibly of hypertension in the long term, and in the short term acute exposures contribute to plaque instability, affect various traditional risk factors and trigger acute cardiovascular events (myocardial ischemia and infarction, stroke, heart failure, arrhythmias, and sudden death), particularly in high-risk subjects. There are currently also significant concerns with the risks of engineered nanoparticles.

  6. Measuring situational awareness and resolving inherent high-level fusion obstacles (United States)

    Sudit, Moises; Stotz, Adam; Holender, Michael; Tagliaferri, William; Canarelli, Kathie


    Information Fusion Engine for Real-time Decision Making (INFERD) is a tool that was developed to supplement current graph matching techniques in Information Fusion models. Based on sensory data and a priori models, INFERD dynamically generates, evolves, and evaluates hypothesis on the current state of the environment. The a priori models developed are hierarchical in nature lending them to a multi-level Information Fusion process whose primary output provides a situational awareness of the environment of interest in the context of the models running. In this paper we look at INFERD's multi-level fusion approach and provide insight on the inherent problems such as fragmentation in the approach and the research being undertaken to mitigate those deficiencies. Due to the large variance of data in disparate environments, the awareness of situations in those environments can be drastically different. To accommodate this, the INFERD framework provides support for plug-and-play fusion modules which can be developed specifically for domains of interest. However, because the models running in INFERD are graph based, some default measurements can be provided and will be discussed in the paper. Among these are a Depth measurement to determine how much danger is presented by the action taking place, a Breadth measurement to gain information regarding the scale of an attack that is currently happening, and finally a Reliability measure to tell the user the credibility of a particular hypothesis. All of these results will be demonstrated in the Cyber domain where recent research has shown to be an area that is welldefined and bounded, so that new models and algorithms can be developed and evaluated.

  7. Intergovernmental relations inherent in the Energy Management Partnership Act: a workshop on information requirements

    Energy Technology Data Exchange (ETDEWEB)

    Hoop, W.J.; Edelson, E.


    This paper summarizes the results of the first of three workshops that were planned to assess the information needed by the Office of Conservation and Solar Energy (CS) to effectively evaluate the pending Energy Management Partnership Act (EMPA); the workshop concentrated on issues of the EMPA hierarchical partnership. The approach utilized offers two major benefits to CS. First, by considering the problem of program evaluation while EMPA is still in the planning stage, this study identifies any baseline information that should be collected prior to implementation of EMPA, and also provides CS with the opportunity to include evaluation considerations in the operating guidelines for the program. Second, by identifying the potential problems and benefits inherent in EMPA and then identifying the information necessary to evaluate these problems and benefits, information requirements tied to the reasons for needing that information are generated, rather than a long unrelated laundry list of information requirements. Drafting of EMPA is not yet complete. When the term EMPA is used here, it refers to a set of bills that are presently being melded together. The original EMPA bill, which originated in DOE, was designed to expand the role of state and local governments in achieving national energy goals. Specifically, EMPA would provide a total of $110 million annually to state and local governments over a five year period to (1) develop an overall state energy plan, (2) consolidate three existing federal energy grant programs, (3) allow the secretary to fund directly innovative projects at the local level, and (4) provide additional assistance to states to cover the administrative costs of existing energy programs. Other bills, which may be passed in conjuncttion with EMPA or incorporated into EMPA, place additional emphasis on the local level by allocating as much as $400 million annually to local governments.

  8. Inferring inherent optical properties and water constituent profiles from apparent optical properties. (United States)

    Fan, Yongzhen; Li, Wei; Calzado, Violeta Sanjuan; Trees, Charles; Stamnes, Snorre; Fournier, Georges; McKee, David; Stamnes, Knut


    The BP09 experiment conducted by the Centre for Maritime Research and Experimentation in the Ligurian Sea in March 2009 provided paired vertical profiles of nadir-viewing radiances L(u)(z) and downward irradiances E(d)(z) and inherent optical properties (IOPs, absorption, scattering and backscattering coefficients). An inversion algorithm was implemented to retrieve IOPs from apparent optical properties (AOPs, radiance reflectance R(L), irradiance reflectance R(E) and diffuse attenuation coefficient K(d)) derived from the radiometric measurements. Then another inversion algorithm was developed to infer vertical profiles of water constituent concentrations, including chlorophyll-a concentration, non-algal particle concentration, and colored dissolved organic matter from the retrieved IOPs based on a bio-optical model. The algorithm was tested on a synthetic dataset and found to give reliable results with an accuracy better than 1%. When the algorithm was applied to the BP09 dataset it was found that good retrievals of IOPs could be obtained for sufficiently deep waters, i.e. for L(u)(z) and E(d)(z) measurements conducted to depths of 50 m or more. This requirement needs to be satisfied in order to obtain a good estimation of the backscattering coefficient. For such radiometric measurements a correlation of 0.88, 0.96 and 0.93 was found between retrieved and measured absorption, scattering and backscattering coefficients, respectively. A comparison between water constituent values derived from the measured IOPs and in-situ measured values, yielded a correlation of 0.80, 0.78, and 0.73 for chlorophyll-a concentration, non-algal particle concentration, and absorption coefficient of colored dissolved organic matter at 443 nm, respectively. This comparison indicates that adjustments to the bio-optical model are needed in order to obtain a better match between inferred and measured water constituent values in the Ligurian Sea using the methodology developed in this paper.

  9. The hype cycle in 3D displays: inherent limits of autostereoscopy (United States)

    Grasnick, Armin


    Since a couple of years, a renaissance of 3dimensional cinema can be observed. Even though the stereoscopy was quite popular within the last 150 years, the 3d cinema has disappeared and re-established itself several times. The first boom in the late 19th century stagnated and vanished after a few years of success, the same happened again in 50's and 80's of the 20th century. With the commercial success of the 3d blockbuster "Avatar" in 2009, at the latest, it is obvious that the 3d cinema is having a comeback. How long will it last this time? There are already some signs of a declining interest in 3d movies, as the discrepancy between expectations and the results delivered becomes more evident. From the former hypes it is known: After an initial phase of curiosity (high expectations and excessive fault tolerance), a phase of frustration and saturation (critical analysis and subsequent disappointment) will follow. This phenomenon is known as "Hype Cycle" The everyday experienced evolution of technology has conditioned the consumers. The expectation "any technical improvement will preserve all previous properties" cannot be fulfilled with present 3d technologies. This is an inherent problem of stereoscopy and autostereoscopy: The presentation of an additional dimension caused concessions in relevant characteristics (i.e. resolution, brightness, frequency, viewing area) or leads to undesirable physical side effects (i.e. subjective discomfort, eye strain, spatial disorientation, feeling of nausea). It will be verified that the 3d apparatus (3d glasses or 3d display) is also the source for these restrictions and a reason for decreasing fascination. The limitations of present autostereoscopic technologies will be explained.

  10. Technical Note: Millimeter precision in ultrasound based patient positioning: Experimental quantification of inherent technical limitations

    Energy Technology Data Exchange (ETDEWEB)

    Ballhausen, Hendrik, E-mail:; Hieber, Sheila; Li, Minglun; Belka, Claus; Reiner, Michael [Department of Radiotherapy and Radiation Oncology, University Hospital of the Ludwig-Maximilians-University, Marchioninistraße 15, 81377 Munich (Germany)


    Purpose: To identify the relevant technical sources of error of a system based on three-dimensional ultrasound (3D US) for patient positioning in external beam radiotherapy. To quantify these sources of error in a controlled laboratory setting. To estimate the resulting end-to-end geometric precision of the intramodality protocol. Methods: Two identical free-hand 3D US systems at both the planning-CT and the treatment room were calibrated to the laboratory frame of reference. Every step of the calibration chain was repeated multiple times to estimate its contribution to overall systematic and random error. Optimal margins were computed given the identified and quantified systematic and random errors. Results: In descending order of magnitude, the identified and quantified sources of error were: alignment of calibration phantom to laser marks 0.78 mm, alignment of lasers in treatment vs planning room 0.51 mm, calibration and tracking of 3D US probe 0.49 mm, alignment of stereoscopic infrared camera to calibration phantom 0.03 mm. Under ideal laboratory conditions, these errors are expected to limit ultrasound-based positioning to an accuracy of 1.05 mm radially. Conclusions: The investigated 3D ultrasound system achieves an intramodal accuracy of about 1 mm radially in a controlled laboratory setting. The identified systematic and random errors require an optimal clinical tumor volume to planning target volume margin of about 3 mm. These inherent technical limitations do not prevent clinical use, including hypofractionation or stereotactic body radiation therapy.

  11. Modelling the inherent optical properties and estimating the constituents' concentrations in turbid and eutrophic waters (United States)

    Gokul, Elamurugu Alias; Shanmugam, Palanisamy; Sundarabalan, Balasubramanian; Sahay, Arvind; Chauhan, Prakash


    Retrieval of the inherent optical properties and estimation of the constituents' concentrations from satellite ocean colour data in turbid and eutrophic waters are important as these products provide innovative opportunities for the study of biological and biogeochemical properties in such optically complex waters. This paper intends to develop models to retrieve absorption coefficients of phytoplankton, suspended sediments and coloured dissolved organic matter and describe vertical profiles of chlorophyll and suspended sediments from satellite ocean colour data. These models make use of the relationships between remote sensing reflectance ratios Rrs (555)/Rrs (443) and Rrs (620)/Rrs (490) versus aph (443) and aph (555), and acdom (443), and ad (443) to derive the model parameters. Validation with the in-situ data obtained from coastal waters around India and other regional waters (e.g., NASA bio-Optical Marine Algorithm Data-Set, NOMAD) shows that the new models are more accurate in terms of producing the spectral absorption coefficients (aph, ad, acdom across the entire visible wavelengths 400-700 nm) in a wide variety of waters. Further comparison with existing models shows advantage of the new models that have important implications for remote sensing of turbid coastal and eutrophic waters. The retrieved absorption coefficients of phytoplankton and suspended sediments (non-algal matter) are also found to relate better to chlorophyll and total suspended sediments. Taking advantages of this, we derive models to determine and describe the vertical profiles of chlorophyll and suspended sediment concentrations along the depth. The model parameters are derived empirically. These new parameterizations show potential in estimating the vertical profiles of chlorophyll and suspended sediments with good accuracy. These results suggest robustness and suitability of the new models for studying the ecologically important components of optically complex turbid and eutrophic

  12. Evolution of stress-induced borehole breakout in inherently anisotropic rock: Insights from discrete element modeling (United States)

    Duan, K.; Kwok, C. Y.


    The aim of this study is to better understand the mechanisms controlling the initiation, propagation, and ultimate pattern of borehole breakouts in shale formation when drilled parallel with and perpendicular to beddings. A two-dimensional discrete element model is constructed to explicitly represent the microstructure of inherently anisotropic rocks by inserting a series of individual smooth joints into an assembly of bonded rigid discs. Both isotropic and anisotropic hollow square-shaped samples are generated to represent the wellbores drilled perpendicular to and parallel with beddings at reduced scale. The isotropic model is validated by comparing the stress distribution around borehole wall and along X axis direction with analytical solutions. Effects of different factors including the particle size distribution, borehole diameter, far-field stress anisotropy, and rock anisotropy are systematically evaluated on the stress distribution and borehole breakout propagation. Simulation results reveal that wider particle size distribution results in the local stress perturbations which cause localization of cracks. Reduction of borehole diameter significantly alters the crack failure from tensile to shear and raises the critical pressure. Rock anisotropy plays an important role on the stress state around wellbore which lead to the formation of preferred cracks under hydrostatic stress. Far-field stress anisotropy plays a dominant role in the shape of borehole breakout when drilled perpendicular to beddings while a secondary role when drilled parallel with beddings. Results from this study can provide fundamental insights on the underlying particle-scale mechanisms for previous findings in laboratory and field on borehole stability in anisotropic rock.

  13. Risco cardiovascular, efetividade e mortalidade Cardiovascular risk, effectiveness and mortality Riesgo cardiovascular, efectividad y mortalidad

    Directory of Open Access Journals (Sweden)

    Juan Gérvas


    Full Text Available

    A Lei de Ferro da Epidemiologia (Ley de Hierro de La Epidemiología diz que todos que nascem, morrem. Por isso, o propósito da Medicina não é evitar a morte por si só, mas evitar as mortes, as doenças e o sofrimento que podem ser medicamente evitáveis.

    No final, todos nossos pacientes morrerão – e nós também, obviamente, morreremos. “Os corpos encontram uma forma de morrer”, e se a causa não for por fome ou desidratação, por motivo congênito e infeccioso, por lesões, câncer ou suicídio, temos que esperar que seja por ‘motivo cardiovascular’, doença pulmonar, insuficiência renal ou hepática, demência ou outras doenças degenerativas. Mas temos que morrer por alguma coisa.

    Morrer por causa cardiovascular não é desonroso, nem refere-se à atenção clínica imperfeita. O fato de a primeira causa de morte ser a cardiovascular não tem nenhuma relação com os cuidados clínicos e nem deveria assustar.

    Entretanto, muitas das mortes por motivo cardiovascular poderiam ser evitadas. Assim, poder-se-ia evitar mortalidade cardiovascular, diminuindo a desigualdade social, por exemplo, com melhor redistribuição da riqueza, melhor educação etc. Os médicos sabem que os fatores adversos psicossociais associados ao fato de pertencer à classe baixa correspondem a 35% do risco atribuído à hipertensão na incidência do infarto do miocárdio (em outra hipótese, pertencer à classe baixa duplica 2,7 tal risco1.

    Também deve-se saber que, contra as mortes cardiovasculares, não há nada como as políticas de saúde pública quanto ao tabagismo (restrições dos lugares onde fumar, aumento do preço do tabaco, campanhas de informação, entre outras.

    Na parte clínica, as mortes cardiovasculares evitáveis devem ser vistas em perspectiva, de acordo com o que seja possível conseguir2. Portanto, por 100.000 habitantes ao ano, o tratamento com inibidores da enzima conversora de angiotensina (IECA

  14. Opto-physiological modeling applied to photoplethysmographic cardiovascular assessment. (United States)

    Hu, Sijung; Azorin-Peris, Vicente; Zheng, Jia


    This paper presents opto-physiological (OP) modeling and its application in cardiovascular assessment techniques based on photoplethysmography (PPG). Existing contact point measurement techniques, i.e., pulse oximetry probes, are compared with the next generation non-contact and imaging implementations, i.e., non-contact reflection and camera-based PPG. The further development of effective physiological monitoring techniques relies on novel approaches to OP modeling that can better inform the design and development of sensing hardware and applicable signal processing procedures. With the help of finite-element optical simulation, fundamental research into OP modeling of photoplethysmography is being exploited towards the development of engineering solutions for practical biomedical systems. This paper reviews a body of research comprising two OP models that have led to significant progress in the design of transmission mode pulse oximetry probes, and approaches to 3D blood perfusion mapping for the interpretation of cardiovascular performance.

  15. Opto-Physiological Modeling Applied to Photoplethysmographic Cardiovascular Assessment

    Directory of Open Access Journals (Sweden)

    Sijung Hu


    Full Text Available This paper presents opto-physiological (OP modeling and its application in cardiovascular assessment techniques based on photoplethysmography (PPG. Existing contact point measurement techniques, i.e., pulse oximetry probes, are compared with the next generation non-contact and imaging implementations, i.e., non-contact reflection and camera-based PPG. The further development of effective physiological monitoring techniques relies on novel approaches to OP modeling that can better inform the design and development of sensing hardware and applicable signal processing procedures. With the help of finite-element optical simulation, fundamental research into OP modeling of photoplethysmography is being exploited towards the development of engineering solutions for practical biomedical systems. This paper reviews a body of research comprising two OP models that have led to significant progress in the design of transmission mode pulse oximetry probes, and approaches to 3D blood perfusion mapping for the interpretation of cardiovascular performance.

  16. The use of echocardiography in acute cardiovascular care

    DEFF Research Database (Denmark)

    Lancellotti, Patrizio; Price, Susanna; Edvardsen, Thor


    of echocardiography in acute cardiovascular care. In this document, we describe the practical applications of echocardiography in patients with acute cardiac conditions, in particular with acute chest pain, acute heart failure, suspected cardiac tamponade, complications of myocardial infarction, acute valvular heart...... disease including endocarditis, acute disease of the ascending aorta and post-intervention complications. Specific issues regarding echocardiography in other acute cardiac care scenarios are also described....

  17. Neurogenesis by Activation of Inherent Neural Stem Cells in the Rat Hippocampus after Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    Bo Zhang; Ren-zhi Wang; Zhi-gang Lian; Yang Song; Yong Yao


    Objective To investigate the changes of neural stem cells (NSCs) in the rat hippocampus after cerebral infarction (CI) and to evaluate the neurogenesis caused by the activation of NSCs. Methods CI models of rats were made and rats were assigned to 6 groups: sham-operated, 1 day, 3 days, 7 days, 14 days, and 28 days after CI. The dynamic expression of bromodeoxyuridine (BrdU), polysialylated neural cell adhesion molecule (PSA-NCAM), glial fibrillary acidic protein (GFAP), and neuronal nuclear antigen (NeuN) were determined by immunohistochemistry and immunofluorescence staining. BrdU was used to mark the proliferated NSCs. PSA-NCAM was used to mark the plasticity of activated NSCs. GFAP and NeuN were used to mark the differentiated NSCs. Results Compared with the controls, the number of BrdU+ cells in the hippocampus increased significantly at 1 day after CI (P < 0.05), reached peak at 7 days after CI (P < 0.05), decreased but still elevated compared with the controls at 14 days after CI (P < 0.05), and nearly unchanged at 28 days after CI. The number of BrdU+/PSA-NCAM+ cells increased significantly at 7 days after CI (P < 0.05), reached peak at 14 days after CI (P < 0.05), and decreased but still elevated compared with the controls at 28 days after CI (P < 0.05). The number of BrdU+/PSA-NCAM+ cells was equal to 60% of the number of BrdU+ cells in all the same period. The number of BrdU+/NeuN+ cells in the hippocampus increased significantly at 14 days after CI (P < 0.05) and reached peak at 28 day after CI (P < 0.05). The number of BrdU+/GFAP+cells in the hippocampus nearly unchanged after CI. Conclusion CI can stimulate the proliferation of inherent NSCs, and most proliferated NSCs may differentiate into neurons and represent neural plasticity.

  18. Independent effects of early-life experience and trait aggression on cardiovascular function. (United States)

    Rana, Samir; Pugh, Phyllis C; Katz, Erin; Stringfellow, Sara A; Lin, Chee Paul; Wyss, J Michael; Stauss, Harald M; White, C Roger; Clinton, Sarah M; Kerman, Ilan A


    Early-life experience (ELE) can significantly affect life-long health and disease, including cardiovascular function. Specific dimensions of emotionality also modify risk of disease, and aggressive traits along with social inhibition have been established as independent vulnerability factors for the progression of cardiovascular disease. Yet, the biological mechanisms mediating these associations remain poorly understood. The present study utilized the inherently stress-susceptible and socially inhibited Wistar-Kyoto rats to determine the potential influences of ELE and trait aggression (TA) on cardiovascular parameters throughout the lifespan. Pups were exposed to maternal separation (MS), consisting of daily 3-h separations of the entire litter from postnatal day (P)1 to P14. The rats were weaned at P21, and as adults were instrumented for chronic radiotelemetry recordings of blood pressure and heart rate (HR). Adult aggressive behavior was assessed using the resident-intruder test, which demonstrated that TA was independent of MS exposure. MS-exposed animals (irrespective of TA) had significantly lower resting HR accompanied by increases in HR variability. No effects of MS on resting blood pressure were detected. In contrast, TA correlated with increased resting mean, systolic, and diastolic arterial pressures but had no effect on HR. TA rats (relative to nonaggressive animals) also manifested increased wall-to-lumen ratio in the thoracic aorta, increased sensitivity to phenylephrine-induced vascular contractility, and increased norepinephrine content in the heart. Together these data suggest that ELE and TA are independent factors that impact baseline cardiovascular function.

  19. An Annotative Review of Multiscale Modeling and its Application to Scales Inherent in the Field of ICME (United States)

    Sullivan, Rani W.; Arnold, Steven M.


    In order to obtain a general understanding of the rich and diverse research being conducted in the area of multiscale modeling (MM), an overview is conducted with a special focus on composite materials. The objective is to glean both qualitative and quantitative information with regards to MM efforts with intentions of revealing some issues that may enable the field of Integrated Computational Materials Engineering (ICME) as well as providing a starting point for specialists and non-specialists in the area of MM with regards to a variety of classifications.

  20. Positive Cardiovascular Health: A Timely Convergence. (United States)

    Labarthe, Darwin R; Kubzansky, Laura D; Boehm, Julia K; Lloyd-Jones, Donald M; Berry, Jarett D; Seligman, Martin E P


    Two concepts, positive health and cardiovascular health, have emerged recently from the respective fields of positive psychology and preventive cardiology. These parallel constructs are converging to foster positive cardiovascular health and a growing collaboration between psychologists and cardiovascular scientists to achieve significant improvements in both individual and population cardiovascular health. We explore these 2 concepts and note close similarities in the measures that define them, the health states that they aim to produce, and their intended long-term clinical and public health outcomes. We especially examine subjective health assets, such as optimism, that are a core focus of positive psychology, but have largely been neglected in preventive cardiology. We identify research to date on positive cardiovascular health, discuss its strengths and limitations thus far, and outline directions for further engagement of cardiovascular scientists with colleagues in positive psychology to advance this new field.

  1. Human and equine cardiovascular endocrinology

    DEFF Research Database (Denmark)

    Vekens, Nicky Van Der; Hunter, Ingrid; Gøtze, Jens Peter


    important species differences, which can partly be explained by variations in physiology or pathophysiology. Most important are physiological differences in heart rate, cardiovascular response to exercise, food and water intake, and molecular elimination in plasma. Pathological differences are even more...... prominent. In humans, troponins and natriuretic peptides are mostly used for the diagnosis of acute coronary syndromes and heart failure. These cardiac entities, however, are rare in horses. In this species, cardiac biomarkers are rather proposed for the assessment of valvular or myocardial disease...

  2. [Cardiovascular risk factors in women]. (United States)

    Cengel, Atiye


    It is estimated that at least 80% of patients with cardiovascular disease (CVD) have conventional risk factors and optimization of these risk factors can reduce morbidity and mortality due to this disease considerably. Contemporary women have increased burden of some of these risk factors such as obesity, metabolic syndrome and smoking. Turkish women have a worse CV risk profile than Turkish men in some aspects. Risk stratification systems such as Framingham have a tendency of underestimating the risk in women. Coronary artery disease remains in vessel wall for a longer period of time in women; therefore obstructive disease appear later in their lifespan necessitating risk stratification systems for estimating their lifetime risk.

  3. Wnt signaling in cardiovascular physiology. (United States)

    Marinou, K; Christodoulides, C; Antoniades, C; Koutsilieris, M


    Wnt signaling pathways play a key role in cardiac development, angiogenesis, and cardiac hypertrophy; emerging evidence suggests that they are also involved in the pathophysiology of atherosclerosis. Specifically, an important role for Wnts has been described in the regulation of endothelial inflammation, vascular calcification, and mesenchymal stem cell differentiation. Wnt signaling also induces monocyte adhesion to endothelial cells and is crucial for the regulation of vascular smooth-muscle cell (VSMC) behavior. We discuss how the Wnt pathways are implicated in vascular biology and outline the role of Wnt signaling in atherosclerosis. Dissecting Wnt pathways involved in atherogenesis and cardiovascular disease may provide crucial insights into novel mechanisms with therapeutic potential for atherosclerosis.

  4. 维生素D定量在心血管疾病诊断中的应用%The application of Vitamin D quantitative in the diagnosis of cardiovascular disease

    Institute of Scientific and Technical Information of China (English)

    伍华颖; 刘健; 彭淑莹


    Objective:To explore the role of Vitamin D in the diagnosis of cardiovascular disease. Methods:We randomly chose 110 patients as the observation group from those who received their treatment for cardiovascular disease in our hospital from March, 2009 to April, 2013, and we chose 110 healthy people as the control group. Then we detected quantitatively 25 (OH) D in each group.Results:In the observation group, only 7 cases 25 (OH) D are with over 30ng/ml while, 101 cases are with that level in the control group . There exists a great disparity between them (χ2=160.05;P0.05). In contrast, the quantitative valueof 25(OH) D in the control group are much higher and are of great statistic significance (t=19.75;P0.05);与对照组比较均明显较低,有统计学意义[t=19.75;P<0.05]。结论:血清维生素D的浓度与心血管疾病的发生、发展呈负相关,临床可通过定量检测血清维生素D对心血管疾病进行辅助诊断。

  5. Preventive Effects of Catechins on Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Xiao-Qiang Chen


    Full Text Available Catechins are polyphenolic phytochemicals with many important physiological activities that play a multifaceted health care function in the human body, especially in the prevention of cardiovascular disease. In this paper, various experimental and clinical studies have revealed the role of catechins in the prevention and treatment of cardiovascular disorders, and we review the preventive effects of catechins on cardiovascular disease from the following aspects: Regulating lipid metabolism, regulating blood lipid metabolism, vascular endothelial protection, and reducing blood pressure.



    Aristizabal, Jose Fernando


      It was considered that physical inactivity is a risk factor for cardiovascular disease independent (1), for this reason today is given much importance to the activityPhysics for this concept becomes protective factor against coronary heart disease. In relation to physical activity and cardiovascular disease, applying the concept ofprimary cardiovascular prevention, authors like Paffenbarger, Morris, have stated that this is beneficial in terms of reducing risk of coronary heart disease (2-3...

  7. Cardiovascular morbidity and mortality after kidney transplantation


    Stoumpos, Sokratis; Jardine, Alan G.; Mark, Patrick B.


    Kidney transplantation is the optimal treatment for patients with end stage renal disease (ESRD) who would otherwise require dialysis. Patients with ESRD are at dramatically increased cardiovascular (CV) risk compared to the general population. As well as improving quality of life, successful transplantation accords major benefits by reducing cardiovascular risk in these patients. Worldwide, cardiovascular disease remains the leading cause of death with a functioning graft and therefore is a ...

  8. Cardiovascular physiology and diseases of the rabbit. (United States)

    Pariaut, Romain


    This article reviews what is known about the diagnosis and management of cardiovascular diseases in the pet rabbit. Current knowledge is based on anecdotal reports, derived from research data using the rabbit as an animal model of human cardiovascular diseases, but most importantly canine and feline cardiology. It is likely that, as cardiovascular diseases are more often recognized, more specific information will soon become available for the treatment of the pet rabbit with cardiac disease.

  9. Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma. (United States)

    Ather, Jennifer L; Chung, Michael; Hoyt, Laura R; Randall, Matthew J; Georgsdottir, Anna; Daphtary, Nirav A; Aliyeva, Minara I; Suratt, Benjamin T; Bates, Jason H T; Irvin, Charles G; Russell, Sheila R; Forgione, Patrick M; Dixon, Anne E; Poynter, Matthew E


    Obese asthma presents with inherent hyperresponsiveness to methacholine or augmented allergen-driven allergic asthma, with an even greater magnitude of methacholine hyperresponsiveness. These physiologic parameters and accompanying obese asthma symptoms can be reduced by successful weight loss, yet the underlying mechanisms remain incompletely understood. We implemented mouse models of diet-induced obesity, dietary and surgical weight loss, and environmental allergen exposure to examine the mechanisms and mediators of inherent and allergic obese asthma. We report that the methacholine hyperresponsiveness in these models of inherent obese asthma and obese allergic asthma manifests in distinct anatomical compartments but that both are amenable to interventions that induce substantial weight loss. The inherent obese asthma phenotype, with characteristic increases in distal airspace tissue resistance and tissue elastance, is associated with elevated proinflammatory cytokines that are reduced with dietary weight loss. Surprisingly, bariatric surgery-induced weight loss further elevates these cytokines while reducing methacholine responsiveness to levels similar to those in lean mice or in formerly obese mice rendered lean through dietary intervention. In contrast, the obese allergic asthma phenotype, with characteristic increases in central airway resistance, is not associated with increased adaptive immune responses, yet diet-induced weight loss reduces methacholine hyperresponsiveness without altering immunological variables. Diet-induced weight loss is effective in models of both inherent and allergic obese asthma, and our examination of the fecal microbiome revealed that the obesogenic Firmicutes/Bacteroidetes ratio was normalized after diet-induced weight loss. Our results suggest that structural, immunological, and microbiological factors contribute to the manifold presentations of obese asthma.

  10. Plant-based assessment of inherent soil productivity and contributions to China's cereal crop yield increase since 1980.

    Directory of Open Access Journals (Sweden)

    Mingsheng Fan

    Full Text Available OBJECTIVE: China's food production has increased 6-fold during the past half-century, thanks to increased yields resulting from the management intensification, accomplished through greater inputs of fertilizer, water, new crop strains, and other Green Revolution's technologies. Yet, changes in underlying quality of soils and their effects on yield increase remain to be determined. Here, we provide a first attempt to quantify historical changes in inherent soil productivity and their contributions to the increase in yield. METHODS: The assessment was conducted based on data-set derived from 7410 on-farm trials, 8 long-term experiments and an inventory of soil organic matter concentrations of arable land. RESULTS: Results show that even without organic and inorganic fertilizer addition crop yield from on-farm trials conducted in the 2000s was significantly higher compared with those in the 1980s - the increase ranged from 0.73 to 1.76 Mg/ha for China's major irrigated cereal-based cropping systems. The increase in on-farm yield in control plot since 1980s was due primarily to the enhancement of soil-related factors, and reflected inherent soil productivity improvement. The latter led to higher and stable yield with adoption of improved management practices, and contributed 43% to the increase in yield for wheat and 22% for maize in the north China, and, 31%, 35% and 22% for early and late rice in south China and for single rice crop in the Yangtze River Basin since 1980. CONCLUSIONS: Thus, without an improvement in inherent soil productivity, the 'Agricultural Miracle in China' would not have happened. A comprehensive strategy of inherent soil productivity improvement in China, accomplished through combining engineering-based measures with biological-approaches, may be an important lesson for the developing world. We propose that advancing food security in 21st century for both China and other parts of world will depend on continuously improving

  11. Increased susceptibility to cardiovascular effects of dihydrocapcaicin in resuscitated rats. Cardiovascular effects of dihydrocapsaicin

    DEFF Research Database (Denmark)

    Fosgerau, Keld; Ristagno, Giuseppe; Jayatissa, Magdalena Niepsuj;


    Survivors of a cardiac arrest often have persistent cardiovascular derangements following cardiopulmonary resuscitation including decreased cardiac output, arrhythmias and morphological myocardial damage. These cardiovascular derangements may lead to an increased susceptibility towards the extern...

  12. Space physiology IV: mathematical modeling of the cardiovascular system in space exploration. (United States)

    Keith Sharp, M; Batzel, Jerry Joseph; Montani, Jean-Pierre


    Mathematical modeling represents an important tool for analyzing cardiovascular function during spaceflight. This review describes how modeling of the cardiovascular system can contribute to space life science research and illustrates this process via modeling efforts to study postflight orthostatic intolerance (POI), a key issue for spaceflight. Examining this application also provides a context for considering broader applications of modeling techniques to the challenges of bioastronautics. POI, which affects a large fraction of astronauts in stand tests upon return to Earth, presents as dizziness, fainting and other symptoms, which can diminish crew performance and cause safety hazards. POI on the Moon or Mars could be more critical. In the field of bioastronautics, POI has been the dominant application of cardiovascular modeling for more than a decade, and a number of mechanisms for POI have been investigated. Modeling approaches include computational models with a range of incorporated factors and hemodynamic sophistication, and also physical models tested in parabolic and orbital flight. Mathematical methods such as parameter sensitivity analysis can help identify key system mechanisms. In the case of POI, this could lead to more effective countermeasures. Validation is a persistent issue in modeling efforts, and key considerations and needs for experimental data to synergistically improve understanding of cardiovascular responses are outlined. Future directions in cardiovascular modeling include subject-specific assessment of system status, as well as research on integrated physiological responses, leading, for instance, to assessment of subject-specific susceptibility to POI or effects of cardiovascular alterations on muscular, vision and cognitive function.

  13. Obstructive sleep apnea syndrome and cardiovascular problems

    Directory of Open Access Journals (Sweden)

    Zuhal Arıtürk Atılgan


    Full Text Available Obstructive sleep apnea syndrome (OSAS is defined as repeated episodes of upper airway occlusion during sleep with consequent excessive daytime sleepiness. Recently, relationship has been found between cardiovascular disease and OSAS. Therefore OSAS has become more popular today. OSAS is associated with the pathogenesis of cardiovascular disease. A large number of studies have demonstrated that OSAS is an independent risk factor of cardiovascular morbidity and mortality. Sleep apnea was shown to be associated with hypertension, ischemic heart disease, stroke, pulmonary hypertension, cardiac arrhythmia, and cardiovascular mortality

  14. Vitamin D and the cardiovascular system. (United States)

    Beveridge, L A; Witham, M D


    Vitamin D, a secosteroid hormone, affects multiple biological pathways via both genomic and nongenomic signalling. Several pathways have potential benefit to cardiovascular health, including effects on parathyroid hormone, the renin-angiotensin-aldosterone system, vascular endothelial growth factor and cytokine production, as well as direct effects on endothelial cell function and myocyte calcium influx. Observational data supports a link between low vitamin D metabolite levels and cardiovascular health. Cross-sectional data shows associations between low 25-hydroxyvitamin D levels and stroke, myocardial infarction, diabetes mellitus, hypertension, and heart failure. Longitudinal data also suggests a relationship with incident hypertension and new cardiovascular events. However, these associations are potentially confounded by reverse causality and by the effects that other cardiovascular risk factors have on vitamin D metabolite levels. Intervention studies to date suggest a modest antihypertensive effect of vitamin D, no effect on serum lipids, a small positive effect on insulin resistance and fasting glucose, and equivocal actions on arterial stiffness and endothelial function. Analysis of cardiovascular event data collected from osteoporosis trials does not currently show a clear signal for reduced cardiovascular events with vitamin D supplementation, but results may be confounded by the coadministration of calcium, and by the secondary nature of the analyses. Despite mechanistic and observational data that suggest a protective role for vitamin D in cardiovascular disease, intervention studies to date are less promising. Large trials using cardiovascular events as a primary outcome are needed before vitamin D can be recommended as a therapy for cardiovascular disease.

  15. Adiponectin provides cardiovascular protection in metabolic syndrome. (United States)

    Okamoto, Yoshihisa


    Adipose tissue plays a central role in the pathogenesis of metabolic syndrome. Adiponectin (APN) is a bioactive adipocytokine secreted from adipocytes. Low plasma APN levels (hypoadiponectinemia) are observed among obese individuals and in those with related disorders such as diabetes, hypertension, and dyslipidemia. APN ameliorates such disorders. Hypoadiponectinemia is also associated with major cardiovascular diseases including atherosclerosis and cardiac hypertrophy. Accumulating evidence indicates that APN directly interacts with cardiovascular tissue and prevents cardiovascular pathology. Increasing plasma APN or enhancing APN signal transduction may be an ideal strategy to prevent and treat the cardiovascular diseases associated with metabolic syndrome. However, further studies are required to uncover the precise biological actions of APN.

  16. Psoriasis: an opportunity to identify cardiovascular risk. (United States)

    Federman, D G; Shelling, M; Prodanovich, S; Gunderson, C G; Kirsner, R S


    Psoriasis is highly prevalent and is associated with skin-associated complaints as well as arthritis, depression and a lower quality of life. Recently, it has been demonstrated that not only do patients with psoriasis have an increased prevalence of cardiovascular risk factors, but an increased risk of myocardial infarction, and for those with severe disease, increased mortality. Dermatologists and other health professionals need to be cognizant of this association and ensure that cardiovascular risk factors are evaluated and treated appropriately in those patients with psoriasis. We review the association between psoriasis, atherosclerosis and inflammation, as well as some treatable cardiovascular risk factors that may prove beneficial in reducing a patient's cardiovascular risk.

  17. Inflammation, Infection, and Future Cardiovascular Risk (United States)


    Cardiovascular Diseases; Coronary Disease; Cerebrovascular Accident; Myocardial Infarction; Venous Thromboembolism; Heart Diseases; Infection; Chlamydia Infections; Cytomegalovirus Infections; Helicobacter Infections; Herpesviridae Infections; Inflammation

  18. [Toxological problems inherent in varnish and paint products used in aeronautics]. (United States)

    Cianetti, E; Bancheri, C


    Paint products and the need for their employment on aircraft and spacecraft are described and reference is made to the types of poisoning that may arise from their application. The main solvents and diluents are listed, together with their toxicological features. Lastly, mention is made of technical products required by the aeronautical regulations, the dangers associated with them, and the preventive measures required.

  19. Cardiovascular Deconditioning in Humans: Alteration in Cardiovascular Regulation and Function During Simulated Microgravity (United States)

    Cohen, Richard


    this contributes to cardiovascular alterations. In these studies, we focus on the basic physiologic mechanisms responsible for the alterations in cardiovascular regulation and function during the simulated microgravity in order to formulate hypotheses regarding what countermeasures are likely to be most effective. Compared to our original proposal, the protocol we are using has been slightly modified to lengthen the bed rest period to 16 days and streamline the data collection. These modifications provide us data on a longer bed rest period and have enabled us to increase our subject throughput. Based on review of our preliminary data we have decided to test a countermeasure which is applied the very end of the bed rest period. We will use the same bed rest protocol to test this countermeasure. We anticipate completing the baseline data collection in our first protocol plus testing of the countermeasure in an additional eight subjects, at which time we plan to initiate the second protocol which includes sleep deprivation. In future studies, we plan to apply CSI to test other potential countermeasures in conjunction with the same bed rest, sleep deprivation and acute stressor models. We also anticipate applying CSI for studying astronauts before and after space flight and ultimately, during space flight. The application of CSI is providing information relevant to the development and evaluation of effective countermeasures allowing humans to adapt appropriately upon re-exposure to a gravity field, and to live and work for longer periods of time in microgravity.

  20. Radiation-induced cardiovascular effects (United States)

    Tapio, Soile

    Recent epidemiological studies indicate that exposure to ionising radiation enhances the risk of cardiovascular mortality and morbidity in a moderate but significant manner. Our goal is to identify molecular mechanisms involved in the pathogenesis of radiation-induced cardiovascular disease using cellular and mouse models. Two radiation targets are studied in detail: the vascular endothelium that plays a pivotal role in the regulation of cardiac function, and the myocardium, in particular damage to the cardiac mitochondria. Ionising radiation causes immediate and persistent alterations in several biological pathways in the endothelium in a dose- and dose-rate dependent manner. High acute and cumulative doses result in rapid, non-transient remodelling of the endothelial cytoskeleton, as well as increased lipid peroxidation and protein oxidation of the heart tissue, independent of whether exposure is local or total body. Proteomic and functional changes are observed in lipid metabolism, glycolysis, mitochondrial function (respiration, ROS production etc.), oxidative stress, cellular adhesion, and cellular structure. The transcriptional regulators Akt and PPAR alpha seem to play a central role in the radiation-response of the endothelium and myocardium, respectively. We have recently started co-operation with GSI in Darmstadt to study the effect of heavy ions on the endothelium. Our research will facilitate the identification of biomarkers associated with adverse cardiac effects of ionising radiation and may lead to the development of countermeasures against radiation-induced cardiac damage.

  1. Insulin resistance and cardiovascular disease. (United States)

    Egan, B M; Greene, E L; Goodfriend, T L


    Cardiovascular risk factors cluster in obese individuals. Insulin resistance emerges as a common pathogenetic denominator underlying the risk factor cluster. Defects in nonesterified fatty acids metabolism have been implicated in the abnormal lipid and glucose metabolism which characterize the cluster. Other evidence also leads to the adipocyte as an important contributor to the risk factor cluster and cardiovascular complications through effects not only on fatty acids but also on leptin, plasminogen activator inhibitor-1, and angiotensinogen, to name a few. Fatty acids are elevated among abdominally obese individuals, are more resistant to suppression by insulin, and may contribute to hypertension. Fatty acids may affect blood pressure by inhibiting endothelial nitric oxide synthase activity and impairing endothelium-dependent vasodilation. Fatty acids increase alpha1-adrenoceptor-mediated vascular reactivity and enhance the proliferation and migration of cultured vascular smooth-muscle cells. Several effects of fatty acids are mediated through oxidative stress. Fatty acids can also interact with other facets of cluster, including increased angiotensin II, to accentuate oxidative stress. Oxidative stress, in turn, is implicated in the pathogenesis of insulin resistance, hypertension, vascular remodeling, and vascular complications. A clearer delineation of the key reactive oxygen signaling pathways and the impact of various interventions on these pathways could facilitate a rationale approach to antioxidant therapy and improved outcomes among the rapidly growing number of high-risk, insulin-resistant, obese individuals.

  2. Marijuana Use and Cardiovascular Disease. (United States)

    Franz, Christopher A; Frishman, William H


    Marijuana is currently the most used illicit substance in the world. With the current trend of decriminalization and legalization of marijuana in the US, physicians in the US will encounter more patients using marijuana recreationally over a diverse range of ages and health states. Therefore, it is relevant to review marijuana's effects on human cardiovascular physiology and disease. Compared with placebo, marijuana cigarettes cause increases in heart rate, supine systolic and diastolic blood pressures, and forearm blood flow via increased sympathetic nervous system activity. These actions increase myocardial oxygen demand to a degree that they can decrease the time to exercise-induced angina in patients with a history of stable angina. In addition, marijuana has been associated with triggering myocardial infarctions (MIs) in young male patients. Smoking marijuana has been shown to increase the risk of MI onset by a factor of 4.8 for the 60 minutes after marijuana consumption, and to increase the annual risk of MI in the daily cannabis user from 1.5% to 3% per year. Human and animal models suggest that this effect may be due to coronary arterial vasospasm. However, longitudinal studies have indicated that marijuana use may not have a significant effect on long-term mortality. While further research is required to definitively determine the impact of marijuana on cardiovascular disease, it is reasonable to recommend against recreational marijuana use, especially in individuals with a history of coronary artery disorders.

  3. Dietary fat and cardiovascular disease?

    Directory of Open Access Journals (Sweden)

    Lie T. Merijanti


    Full Text Available Dietary saturated fat (SF intake has been shown to increase low density lipoprotein (LDL cholesterol and therefore has been associated with increased risk of cardiovascular disease (CVD. This evidence coupled with inferences from epidemiologic studies and clinical trials, had led to longstanding public health recommendations for limiting SF intake as a means of preventing CVD. However the relationship between SF and CVD risk remains controversial, due at least in part to the intrinsic limitations of clinical studies that have evaluated this relationship. A recent meta analysis showed that current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids (PUFA and low consumption of total SF. They found weak positive associations between circulating palmitic and stearic acids (found largely in palm oil and animal fats, respectively and CVD, whereas circulating margaric acid (a dairy fat significantly reduced the risk of CVD.(2,3 Saturated fat are not associated with all cause mortality, CVD, CHD, ischemic stroke or type 2 diabetes, but the evidence is heterogenous with methodological limitations.

  4. Iron deficiency and cardiovascular disease. (United States)

    von Haehling, Stephan; Jankowska, Ewa A; van Veldhuisen, Dirk J; Ponikowski, Piotr; Anker, Stefan D


    Iron deficiency affects up to one-third of the world's population, and is particularly common in elderly individuals and those with certain chronic diseases. Iron excess can be detrimental in cardiovascular illness, and research has now also brought anaemia and iron deficiency into the focus of cardiovascular medicine. Data indicate that iron deficiency has detrimental effects in patients with coronary artery disease, heart failure (HF), and pulmonary hypertension, and possibly in patients undergoing cardiac surgery. Around one-third of all patients with HF, and more than one-half of patients with pulmonary hypertension, are affected by iron deficiency. Patients with HF and iron deficiency have shown symptomatic improvements from intravenous iron administration, and some evidence suggests that these improvements occur irrespective of the presence of anaemia. Improved exercise capacity has been demonstrated after iron administration in patients with pulmonary hypertension. However, to avoid iron overload and T-cell activation, it seems that recipients of cardiac transplantations should not be treated with intravenous iron preparations.

  5. Enfermedad cardiovascular en Costa Rica

    Directory of Open Access Journals (Sweden)

    Lizzie M. Castillo S


    Full Text Available En Costa Rica la enfermedad cardiovascular cobra en promedio 6 vidas por día, lo cual representa un aumento escalonado en los últimos años, debido en su mayoría a cambios en el estilo de vida del costarricense. Además, llama la atención, que factores de riesgo para enfermedad cardiovascular como son el fumado, obesidad infantil, alcoholismo, diabetes, dislipidemia e hipertensión han mostrado un incremento en su incidencia. Por lo tanto,se pretende realizar una revisión de los programas de detección y de atención temprana a nivel institucional, en lo que respecta a la Caja Costarricense de Seguro Social como ente responsable de llevar a cabo los mismos. El adecuado conocimiento y uso de los programas pretende una disminución en la morbimortalidad de la misma,y su aplicación se hace obligatoria para el manejo de pacientes en atención primaria.

  6. Cardiovascular and non-cardiovascular mortality in dialysis patients : where is the link?

    NARCIS (Netherlands)

    Jager, Kitty J.; Lindholm, Bengt; Goldsmith, David; Fliser, Danilo; Wiecek, Andrzej; Suleymanlar, Gultekin; Ortiz, Alberto; Massy, Ziad; Martinez-Castelao, Alberto; Agarwal, Rajiv; Blankestijn, Peter J.; Covic, Adrian; London, Gerard; Zoccali, Carmine; Dekker, Friedo W.


    Over the past decade, the research agenda in dialysis has been dominated by studies on risk factors associated with cardiovascular mortality. It has now become increasingly clear that in dialysis patients, non-cardiovascular causes of death are increased to the same extent as cardiovascular mortalit

  7. Evaluation of inherent toxicology and biocompatibility of magnesium phosphate bone cement. (United States)

    Yu, Yonglin; Wang, Jing; Liu, Changsheng; Zhang, Bingwen; Chen, Honghong; Guo, Han; Zhong, Gaoren; Qu, Weidong; Jiang, Songhui; Huang, Huangyuan


    Magnesium phosphate cement (MPC) is a kind of novel biodegradable bone adhesive for its distinct performance. However, there is few research work concerning on the systemic biocompatibility and genetic toxicological evaluation of MPC. In this study, the investigation on the inherited toxicology of MPC including gene mutation assay (Ames test), chromosome aberration assay (micronucleus test), and DNA damage assay (unscheduled DNA synthesis test) were carried out. Fracture healing and degradation behavior were explored for the evaluation of the biocompatibility of MPC, using macroscopical histological, histomorphometrical, and scanning electron microscopical methods. The results of mutagenicity and potential carcinogenicity of MPC extracts were negative, and the animal implantation illustrated no toxicity and good resorption. The study suggested that bioresorbable MPC was safe for application and might have potential applications for physiological fracture fixation.

  8. Reducing Inherent Deviations in Galvanometer Scanning Systems for Large Area Processing


    Ortega Delgado, Moisés Alberto


    Galvanometer laser machining is a well-established laser machining technique in which the laser beam is positioned on a working field by means of mirrors mounted in galvanometers. Nonetheless, new applications make necessary the development of innovative techniques for increasing the performance of such systems. Aside all the advantages of this technique like given resolution, repeatability and velocity, a limited working area is an important drawback. In this thesis work, the limitation...

  9. Development of inherently safe and environmentally acceptable intelligent processing technologies for HTS materials

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, E.J.; Wangen, L.E.; Ott, K.C.; Muenchausen, R.E.; Parkinson, W.J. (Los Alamos National Lab., NM (USA))


    The development of new processing technologies for the production, fabrication, and application of advanced materials proceeds through several complementary dimensions. The advanced materials dimension includes basic research on materials synthesis, composition, and properties; materials processing research; engineering characterization and materials applications; and product and process engineering. The health and environmental dimension includes identification of potential health and environmental constraints; characterization of candidate processes for waste and effluent quality; process optimization for both economic and environmental benefit; and development of control strategies to deal with health and environmental problems that cannot be solved through process modification. The intelligent processing dimension includes application of available sensors and the development of new diagnostics for real-time process measurements; development of control strategies and expert systems to use these process measurements for real-time process control; and development of capabilities to optimize working processes in real-time for both product quality and environmental acceptability. This paper discusses these issues in the context of the Laboratory's efforts to develop technologies based on the processing of the new high-temperature superconducting ceramic oxides.

  10. Cardiovascular dysfunction in obesity and new diagnostic imaging techniques: the role of noninvasive image methods

    Directory of Open Access Journals (Sweden)

    Barbosa JA


    Full Text Available José Augusto A Barbosa¹, Alexandre B Rodrigues¹, Cleonice Carvalho C Mota¹, Márcia M Barbosa², Ana C Simões e Silva¹¹Department of Pediatrics, Faculty of Medicine, Federal University of Minas Gerais (UFMG, Belo Horizonte, Minas Gerais, Brazil; ²Ecocenter, Socor Hospital, Belo Horizonte, Minas Gerais, BrazilAbstract: Obesity is a major public health problem affecting adults and children in both developed and developing countries. This condition often leads to metabolic syndrome, which increases the risk of cardiovascular disease. A large number of studies have been carried out to understand the pathogenesis of cardiovascular dysfunction in obese patients. Endothelial dysfunction plays a key role in the progression of atherosclerosis and the development of coronary artery disease, hypertension and congestive heart failure. Noninvasive methods in the field of cardiovascular imaging, such as measuring intima-media thickness, flow-mediated dilatation, tissue Doppler, and strain, and strain rate, constitute new tools for the early detection of cardiac and vascular dysfunction. These techniques will certainly enable a better evaluation of initial cardiovascular injury and allow the correct, timely management of obese patients. The present review summarizes the main aspects of cardiovascular dysfunction in obesity and discusses the application of recent noninvasive imaging methods for the early detection of cardiovascular alterations.Keywords: cardiovascular risk, endothelium dysfunction, obesity, strain and strain rate, tissue Doppler

  11. Disparities in heart failure and other cardiovascular diseases among women. (United States)

    McSweeney, Jean; Pettey, Christina; Lefler, Leanne L; Heo, Seongkum


    This article reviews literature pertinent to cardiovascular disparities in women, focusing primarily on heart failure (HF). It provides an in-depth look at causes, biological influences, self-management and lack of adherence to HF-treatment guidelines in women. Disparities in treatment of causative factors of HF, such as myocardial infarction and hypertension, contribute to women having poorer HF outcomes than men. This article discusses major contributing reasons for nonadherence to medication regimes for HF in women, including advanced age at time of diagnosis, likelihood of multiple comorbidities, lack of social support and low socioeconomic status. Limited inclusion of women in clinical trials and the scarcity of gender analyses for HF and other cardiovascular diseases continues to limit the applicability of research findings to women.

  12. [Thermal therapy for the management of cardiovascular pathology]. (United States)

    Persiianova-Dubrova, A L; Badalov, N G


    This paper reports the results of analysis of the study on the effect of thermal therapy in the patients presenting with cardiovascular diseases including coronary heart disease, chronic heart failure, and myocardial infarction. It is shown that the correct application of the "Finnish" and infrared sauna taking into consideration specific clinical characteristics of the disease in question and with strict compliance to the relevant methodological recommendations can produce beneficial effects in the form of the improved endothelial function, reduced heart rate variability and oxidative stress as well as enhanced physical performance. It is concluded that full-scale studies in accordance with the principles of evidence-based medicine are needed to further improve the effectiveness of the thermal treatment of cardiovascular diseases and the reliability of the data obtained.

  13. Cardiovascular issues in respiratory care. (United States)

    Pinsky, Michael R


    The hemodynamic effects of ventilation are complex but can be grouped under four clinically relevant concepts. First, spontaneous ventilation is exercise, and critically ill patients may not withstand the increased work of breathing. Initiation of mechanical ventilatory support will improve oxygen delivery to the remainder of the body by decreasing oxygen consumption. To the extent that mixed venous oxygen also increases, Pao(2) will increase without any improvement in gas exchange. Similarly, weaning from mechanical ventilatory support is a cardiovascular stress test. Patients who fail to wean also manifest cardiovascular insufficiency during the failed weaning attempts. Improving cardiovascular reserve or supplementing support with inotropic therapy may allow patients to wean from mechanical ventilation. Second, changes in lung volume alter autonomic tone and pulmonary vascular resistance (PVR), and at high lung volumes compress the heart in the cardiac fossa. Hyperinflation increases PVR and pulmonary artery pressure, impeding right ventricular ejection. Decreases in lung volume induce alveolar collapse and hypoxia, stimulating an increased pulmonary vasomotor tone by the process of hypoxic pulmonary vasoconstriction. Recruitment maneuvers, positive end-expiratory pressure, and continuous positive airway pressure may reverse hypoxic pulmonary vasoconstriction and reduce pulmonary artery pressure. Third, spontaneous inspiration and spontaneous inspiratory efforts decrease intrathoracic pressure (ITP). Since diaphragmatic descent increases intra-abdominal pressure, these combined effects cause right atrial pressure inside the thorax to decrease but venous pressure in the abdomen to increase, markedly increasing the pressure gradient for systemic venous return. Furthermore, the greater the decrease in ITP, the greater the increase in left ventricular (LV) afterload for a constant arterial pressure. Mechanical ventilation, by abolishing the negative swings in ITP

  14. Cardiovascular Disease and Cancer: Student Awareness Activities. (United States)

    Meyer, James H., Comp.

    Awareness activities pertaining to cancer and cardiovascular disease are presented as a supplement for high school science classes. The exercises can be used to enrich units of study dealing with the circulatory system, the cell, or human diseases. Eight activities deal with the following topics: (1) cardiovascular disease risk factors; (2)…

  15. Genetic influences on cardiovascular stress reactivity

    NARCIS (Netherlands)

    Wu, Ting; Snieder, Harold; de Geus, Eco


    Individual differences in the cardiovascular response to stress play a central role in the reactivity hypothesis linking frequent exposure to psychosocial stress to adverse outcomes in cardiovascular health. To assess the importance of genetic factors, a meta-analysis was performed on all published

  16. Subclinical organ damage and cardiovascular risk prediction

    DEFF Research Database (Denmark)

    Sehestedt, Thomas; Olsen, Michael H


    by measuring subclinical organ damage. We have (i) reviewed recent studies linking markers of subclinical organ damage in the heart, blood vessels and kidney to cardiovascular risk; (ii) discussed the evidence for improvement in cardiovascular risk prediction using markers of subclinical organ damage; (iii...

  17. Hepatitis C virus and cardiovascular: A review

    Directory of Open Access Journals (Sweden)

    Salvatore Petta


    Full Text Available Chronic hepatitis C virus (HCV infection is a systemic disease that leads to increased risks of cirrhosis and its complications, as well as extrahepatic disturbances, including immune-related disorders and metabolic alterations such as insulin resistance and steatosis. Recent accumulating evidence suggests that HCV infection can increase cardiovascular risk, and that viral eradication can improve cardiovascular outcomes in the clinical setting. These data are strengthened by evidence identifying potential mechanisms (indirectly linking HCV infection to vascular damage. However, the high prevalence of both HCV infection and cardiovascular alterations, as well as the presence of contrasting results not identifying any association between HCV infection and cardiovascular dysfunction, provides uncertainty about a direct association of HCV infection with cardiovascular risk. Further studies are needed to clarify definitively the role of HCV infection in cardiovascular alterations, as well as the impact of viral eradication on cardiovascular outcomes. These features are now more attractive, considering the availability of new, safe, and very effective interferon-free antiviral agents for the treatment of HCV infection. This review aims to discuss carefully available data on the relationship between HCV infection and cardiovascular risk.

  18. Preeclampsia : At risk for remote cardiovascular disease

    NARCIS (Netherlands)

    Harskamp, Ralf E.; Zeeman, Gerda G.


    Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to 3.07

  19. Detection of cardiovascular anomalies: Hybrid systems approach

    KAUST Repository

    Ledezma, Fernando


    In this paper, we propose a hybrid interpretation of the cardiovascular system. Based on a model proposed by Simaan et al. (2009), we study the problem of detecting cardiovascular anomalies that can be caused by variations in some physiological parameters, using an observerbased approach. We present the first numerical results obtained. © 2012 IFAC.

  20. Cardiovascular Reactivity, Stress, and Physical Activity

    Directory of Open Access Journals (Sweden)

    Chun-Jung eHuang


    Full Text Available Psychological stress has been proposed as a major contributor to the progression of cardiovascular disease (CVD. Acute mental stress can activate the sympathetic-adrenal-medullary (SAM axis, eliciting the release of catecholamines (NE and EPI resulting in the elevation of heart rate (HR and blood pressure (BP. Combined stress (psychological and physical can exacerbate these cardiovascular responses, which may partially contribute to the elevated risk of CVD and increased proportionate mortality risks experienced by some occupations (e.g., firefighting and law enforcement. Studies have supported the benefits of physical activity on physiological and psychological health, including the cardiovascular response to acute stress. Aerobically trained individuals exhibit lower sympathetic nervous system (e.g., HR reactivity and enhanced cardiovascular efficiency (e.g., lower vascular reactivity and decreased recovery time in response to physical and/or psychological stress. In addition, resistance training has been demonstrated to attenuate cardiovascular responses and improve mental health. This review will examine stress-induced cardiovascular reactivity and plausible explanations for how exercise training and physical fitness (aerobic and resistance exercise can attenuate cardiovascular responses to stress. This enhanced functionality may facilitate a reduction in the incidence of stroke and myocardial infarction. Finally, this review will also address the interaction of obesity and physical activity on cardiovascular reactivity and CVD.

  1. Coffee and cardiovascular risk; an epidemiological study

    NARCIS (Netherlands)

    A.A.A. Bak (Annette)


    textabstractThis thesis comprises several studies on the effect of coffee and caffeine on cardiovascular risk in general, and the effect on serum lipids, blood pressure and selected hemostatic variables in particular. The association between coffee use and cardiovascular morbidity and mortality was

  2. Stable Vertical Takeoff of an Insect-Mimicking Flapping-Wing System Without Guide Implementing Inherent Pitching Stability

    Institute of Scientific and Technical Information of China (English)

    Hoang Vu Phan; Quoc Viet Nguyen; Quang Tri Truong; Tien Van Truong; Hoon Cheol Park; Nam Seo Goo; Doyoung Byun; Min Jun Kim


    We briefly summarized how to design and fabricate an insect-mimicking flapping-wing system and demonstrate how to implement inherent pitching stability for stable vertical takeoff.The effect of relative locations of the Center of Gravity (CG) and the mean Aerodynamic Center (AC) on vertical flight was theoretically examined through static force balance consideration.We conducted a series of vertical takeoff tests in which the location of the mean AC was determined using an unsteady Blade Element Theory (BET) previously developed by the authors.Sequential images were captured during the takeoff tests using a high-speed camera.The results demonstrated that inherent pitching stability for vertical takeoff can be achieved by controlling the relative position between the CG and the mean AC of the flapping system.

  3. Role of Telomerase in the Cardiovascular System

    Directory of Open Access Journals (Sweden)

    Mark Zurek


    Full Text Available Aging is one major risk factor for the incidence of cardiovascular diseases and the development of atherosclerosis. One important enzyme known to be involved in aging processes is Telomerase Reverse Transcriptase (TERT. After the discovery of the enzyme in humans, TERT had initially only been attributed to germ line cells, stem cells and cancer cells. However, over the last few years it has become clear that TERT is also active in cells of the cardiovascular system including cardiac myocytes, endothelial cells, smooth muscle cells and fibroblasts. Interference with the activity of this enzyme greatly contributes to cardiovascular diseases. This review will summarize the findings on the role of TERT in cardiovascular cells. Moreover, recent findings concerning TERT in different mouse models with respect to cardiovascular diseases will be described. Finally, the extranuclear functions of TERT will be covered within this review.

  4. Maintained intentional weight loss reduces cardiovascular outcomes

    DEFF Research Database (Denmark)

    Caterson, I D; Finer, N; Coutinho, W


    Aim: The Sibutramine Cardiovascular OUTcomes trial showed that sibutramine produced greater mean weight loss than placebo but increased cardiovascular morbidity but not mortality. The relationship between 12-month weight loss and subsequent cardiovascular outcomes is explored. Methods: Overweight/obese...... change to Month 12 was -4.18 kg (sibutramine) or -1.87 kg (placebo). Degree of weight loss during Lead-in Period or through Month 12 was associated with a progressive reduction in risk for the total population in primary outcome events and cardiovascular mortality over the 5-year assessment. Although...... more events occurred in the randomized sibutramine group, on an average, a modest weight loss of approximately 3 kg achieved in the Lead-in Period appeared to offset this increased event rate. Moderate weight loss (3-10 kg) reduced cardiovascular deaths in those with severe, moderate or mild...

  5. Cardiovascular death and manic-depressive psychosis

    DEFF Research Database (Denmark)

    Weeke, A; Juel, K; Vaeth, M


    In order to study if tricyclic antidepressant drugs (TCA) in therapeutic doses increase the risk of death due to cardiovascular causes, the relative mortality from cardiovascular diseases was studied in two large groups of first hospitalized manic-depressive patients, one from the TCA era......, the other from the period just before the introduction of TCA. Both groups were selected from the Danish Psychiatric Central Register and followed for an average of 4.5 years. Among 2662 manic-depressive men hospitalized between 1969 and 1976, the relative cardiovascular mortality was 1.53 compared...... to the general population. Among 1133 such cases admitted between 1950 and 1956, the rate was 1.87. Our findings do not support the hypothesis that TCA contribute to the cardiovascular mortality in manic-depressives and even support suggestions that TCA treatment may lower the risk of death by cardiovascular...

  6. Racism and cardiovascular disease: implications for nursing. (United States)

    Jackson, Jennifer; McGibbon, Elizabeth; Waldron, Ingrid


    The social determinants of health (SDH) are recognized as a prominent influence on health outcomes across the lifespan. Racism is identified as a key SDH. In this article, the authors describe the concept of racism as an SDH, its impact in discriminatory actions and inactions, and the implications for cardiovascular nurses. Although research in Canada on the links among racism, stress, and cardiovascular disease is limited, there is growing evidence about the stress of racism and its long-term impact on cardiovascular health. The authors discuss how cardiovascular nursing could be enhanced through an understanding of racism-related stress, and race-based differences in cardiovascular care. The authors conclude with strategies for action to address this nursing concern.

  7. Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Jie Wang


    Full Text Available Recent studies demonstrated that mitochondria play an important role in the cardiovascular system and mutations of mitochondrial DNA affect coronary artery disease, resulting in hypertension, atherosclerosis, and cardiomyopathy. Traditional Chinese medicine (TCM has been used for thousands of years to treat cardiovascular disease, but it is not yet clear how TCM affects mitochondrial function. By reviewing the interactions between the cardiovascular system, mitochondrial DNA, and TCM, we show that cardiovascular disease is negatively affected by mutations in mitochondrial DNA and that TCM can be used to treat cardiovascular disease by regulating the structure and function of mitochondria via increases in mitochondrial electron transport and oxidative phosphorylation, modulation of mitochondrial-mediated apoptosis, and decreases in mitochondrial ROS. However further research is still required to identify the mechanism by which TCM affects CVD and modifies mitochondrial DNA.

  8. The cardiovascular effects of metformin: lost in translation?

    NARCIS (Netherlands)

    Riksen, N.P.; Tack, C.J.J.


    PURPOSE OF REVIEW: In overweight patients with diabetes, treatment with metformin improves cardiovascular outcomes. This observation has fuelled the hypothesis that metformin has direct cardiovascular protective properties over and above glucose lowering. Here, we discuss the various cardiovascular

  9. [Branch retinal vein occlusion: high time for cardiovascular risk management

    NARCIS (Netherlands)

    Bredie, S.J.H.


    Cardiovascular risk management is common in patients suffering from manifest cardiovascular disease, hypertension, hyperlipidaemia and diabetes mellitus. It is generally accepted that medication is the most effective treatment for reducing cardiovascular morbidity and mortality in these patients. Re

  10. [Physical activity and cardiovascular health]. (United States)

    Temporelli, Pier Luigi


    It is well known that regular moderate physical activity, in the context of a healthy lifestyle, significantly reduces the likelihood of cardiovascular events, both in primary and secondary prevention. In addition, it is scientifically proven that exercise can reduce the incidence of diabetes, osteoporosis, depression, breast cancer and colon cancer. Despite this strong evidence, sedentary lifestyle remains a widespread habit in the western world. Even in Italy the adult population has a poor attitude to regular physical activity. It is therefore necessary, as continuously recommended by the World Health Organization, to motivate people to "move" since the transition from inactivity to regular light to moderate physical activity has a huge impact on health, resulting in significant savings of resources. We do not need to be athletes to exercise - it should be part of all our daily routines.

  11. Subclinical Hypothyroidism and Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Sunghwan Suh


    Full Text Available Subclinical hypothyroidism (SCH is a common disorder that is characterized by elevated thyroid-stimulating hormone levels in conjunction with free thyroxine concentrations within the normal reference range. Thyroid hormones are known to affect the heart and vasculature and, as a result, the impact of SCH on the cardiovascular (CV system has recently become an important topic of research. Strong evidence points to a link between SCH and CV risk factors such as alterations in blood pressure, lipid levels, and atherosclerosis. Additionally, accumulating evidence indicates that SCH is associated with metabolic syndrome and heart failure. The present review proposes that SCH may be a potentially modifiable risk factor of CV disease and mortality. However, large-scale clinical trials with appropriate power investigating the risks and benefits of SCH treatment are required to determine whether these benefits can be achieved with levothyroxine therapy.

  12. Polyphenols, inflammation, and cardiovascular disease. (United States)

    Tangney, Christy C; Rasmussen, Heather E


    Polyphenols are compounds found in foods such as tea, coffee, cocoa, olive oil, and red wine and have been studied to determine if their intake may modify cardiovascular disease (CVD) risk. Historically, biologic actions of polyphenols have been attributed to antioxidant activities, but recent evidence suggests that immunomodulatory and vasodilatory properties of polyphenols may also contribute to CVD risk reduction. These properties will be discussed, and recent epidemiological evidence and intervention trials will be reviewed. Further identification of polyphenols in foods and accurate assessment of exposures through measurement of biomarkers (i.e., polyphenol metabolites) could provide the needed impetus to examine the impact of polyphenol-rich foods on CVD intermediate outcomes (especially those signifying chronic inflammation) and hard endpoints among high risk patients. Although we have mechanistic insight into how polyphenols may function in CVD risk reduction, further research is needed before definitive recommendations for consumption can be made.

  13. Cardiovascular Disease and Thyroid Function

    DEFF Research Database (Denmark)

    Faber, Jens; Selmer, Christian


    , a progressively increased risk in people with different levels of reduced TSH to a physiologically 'dose-dependent' effect of thyroid hormones on the heart in overt hyperthyroidism. Heart failure represents an intriguing clinical situation in which triiodothyronine treatment might be beneficial. In conclusion......, subclinical dysthyroid states affect the heart with subsequent changes in morbidity and mortality. Subclinical hyperthyroidism seems a more serious condition than subclinical hypothyroidism, which should affect treatment decision in a more aggressive manner. © 2014 S. Karger AG, Basel.......Thyroid function has a profound effect on the heart, and both all-cause and cardiovascular mortality rates are increased in hyperthyroidism. New-onset atrial fibrillation carries a prolonged risk for the development of hyperthyroidism, suggesting altered availability of thyroid hormones...

  14. [Cardiovascular complications of hypertensive crisis]. (United States)

    Rosas-Peralta, Martín; Borrayo-Sánchez, Gabriela; Madrid-Miller, Alejandra; Ramírez-Arias, Erick; Pérez-Rodríguez, Gilberto


    It is inexorable that a proportion of patients with systemic arterial hypertension will develop a hypertensive crisis at some point in their lives. The hypertensive crises can be divided in hypertensive patients with emergency or hypertensive emergency, according to the presence or absence of acute end-organ damage. In this review, we discuss the cardiovascular hypertensive emergencies, including acute coronary syndrome, congestive heart failure, aortic dissection and sympathomimetic hypertensive crises (those caused by cocaine use included). Each is presented in a unique way, although some patients with hypertensive emergency report non-specific symptoms. Treatment includes multiple medications for quick and effective action with security to reduce blood pressure, protect the function of organs remaining, relieve symptoms, minimize the risk of complications and improve patient outcomes.

  15. Cardiovascular adaptations to exercise training

    DEFF Research Database (Denmark)

    Hellsten, Ylva; Nyberg, Michael


    Aerobic exercise training leads to cardiovascular changes that markedly increase aerobic power and lead to improved endurance performance. The functionally most important adaptation is the improvement in maximal cardiac output which is the result of an enlargement in cardiac dimension, improved...... demands and perfusion levels, arteries, arterioles, and capillaries adapt in structure and number. The diameters of the larger conduit and resistance arteries are increased minimizing resistance to flow as the cardiac output is distributed in the body and the wall thickness of the conduit and resistance...... arteries is reduced, a factor contributing to increased arterial compliance. Endurance training may also induce alterations in the vasodilator capacity, although such adaptations are more pronounced in individuals with reduced vascular function. The microvascular net increases in size within the muscle...

  16. Understanding changes in cardiovascular pathophysiology. (United States)

    Chummun, Harry

    Cardiovascular pathophysiological changes, such as hypertension and enlarged ventricles, reflect the altered functions of the heart and its circulation during ill-health. This article examines the normal and altered anatomy of the cardiac valves, the contractile elements and enzymes of the myocardium, the significance of the different factors associated with cardiac output, and the role of the autonomic nervous system in the heart beat. It also explores how certain diseases alter these functions and result in cardiac symptoms. Nurses can benefit from knowledge of these specific changes, for example, by being able to ask relevant questions in order to ascertain the nature of a patients condition, by being able to take an effective patient history and by being able to read diagnostic results, such as electrocardiograms and cardiac enzyme results. All this will help nurses to promote sound cardiac care based on a physiological rationale.

  17. Movie Popularity Classification based on Inherent Movie Attributes using C4.5, PART and Correlation Coefficient

    DEFF Research Database (Denmark)

    Ibnal Asad, Khalid; Ahmed, Tanvir; Rahman, Md. Saiedur


    Abundance of movie data across the internet makes it an obvious candidate for machine learning and knowledge discovery. But most researches are directed towards bi-polar classification of movie or generation of a movie recommendation system based on reviews given by viewers on various internet si...... propose classification scheme of pre-release movie popularity based on inherent attributes using C4.S and PART classifier algorithm and define the relation between attributes of post release movies using correlation coefficient....

  18. Non-cardiovascular findings in clinical cardiovascular magnetic resonance imaging in children

    Energy Technology Data Exchange (ETDEWEB)

    Ghadimi Mahani, Maryam [University of Michigan Health System, C.S. Mott Children' s Hospital, Department of Radiology, Section of Pediatric Radiology, Ann Arbor, MI (United States); Morani, Ajaykumar C. [The University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Houston, TX (United States); Lu, Jimmy C.; Dorfman, Adam L. [University of Michigan Health System, C.S. Mott Children' s Hospital, Department of Pediatrics and Communicable Diseases, Division of Pediatric Cardiology, Ann Arbor, MI (United States); Fazeli Dehkordy, Soudabeh [University of Michigan Health System, C.S. Mott Children' s Hospital, Department of Radiology, Section of Pediatric Radiology, Ann Arbor, MI (United States); Providence Hospital and Medical Centers, Department of Graduate Medical Education, Southfield, MI (United States); Jeph, Sunil [The University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Houston, TX (United States); Geisinger Medical Center, Department of Radiology, Danville, PA (United States); Agarwal, Prachi P. [University of Michigan Health System, Department of Radiology, Division of Cardiothoracic Radiology, Ann Arbor, MI (United States)


    With increasing use of pediatric cardiovascular MRI, it is important for all imagers to become familiar with the spectrum of non-cardiovascular imaging findings that can be encountered. This study aims to ascertain the prevalence and nature of these findings in pediatric cardiovascular MRIs performed at our institution. We retrospectively evaluated reports of all cardiovascular MRI studies performed at our institute from January 2008 to October 2012 in patients younger than18 years. Most studies (98%) were jointly interpreted by a pediatric cardiologist and a radiologist. We reviewed the electronic medical records of all cases with non-cardiovascular findings, defined as any imaging finding outside the cardiovascular system. Non-cardiovascular findings were classified into significant and non-significant, based on whether they were known at the time of imaging or they required additional workup or a change in management. In 849 consecutive studies (mean age 9.7 ± 6.3 years), 145 non-cardiovascular findings were found in 140 studies (16.5% of total studies). Overall, 51.0% (74/145) of non-cardiovascular findings were in the abdomen, 30.3% (44/145) were in the chest, and 18.6% (27/145) were in the spine. A total of 19 significant non-cardiovascular findings were observed in 19 studies in individual patients (2.2% of total studies, 47% male, mean age 5.9 ± 6.7 years). Significant non-cardiovascular findings included hepatic adenoma, arterially enhancing focal liver lesions, asplenia, solitary kidney, pelvicaliectasis, renal cystic diseases, gastric distention, adrenal hemorrhage, lung hypoplasia, air space disease, bronchial narrowing, pneumomediastinum and retained surgical sponge. Non-cardiovascular findings were seen in 16.5% of cardiovascular MRI studies in children, of which 2.2% were clinically significant findings. Prevalence and nature of these non-cardiovascular findings are different from those reported in adults. Attention to these findings is important

  19. Superconductor-Magnet Bearings With Inherent Stability and Velocity-Independent Drag Torque (United States)

    Lee, Eun-Jeong; Ma, Ki Bui; Wilson, Thomas L.; Chu, Wei-Kan


    A hybrid superconductor magnet bearing system has been developed based on passive magnetic levitation and the flux pinning effect of high-temperature superconductivity. The rationale lies in the unique capability of a high-temperature superconductor (HTS) to enhance system stability passively without power consumption. Characterization experiments have been conducted to understand its dynamic behavior and to estimate the required motor torque for its driving system design. These experiments show that the hybrid HTS-magnet bearing system has a periodic oscillation of drag torque due mainly to the nonuniform magnetic field density of permanent magnets. Furthermore, such a system also suffers from a small superimposed periodic oscillation introduced by the use of multiple HTS disks rather than a uniform annulus of HTS material. The magnitude of drag torque is velocity independent and very small. These results make this bearing system appealing for high-speed application. Finally, design guidelines for superconducting bearing systems are suggested based on these experimental results.

  20. Does cardiovascular reactivity during speech reflect self-construction processes? (United States)

    Lyons, A C; Spicer, J; Tuffin, K; Chamberlain, K


    Abstract Substantial empirical research has been undertaken on cardiovascular reactivity (CVR). however interpretation of this research is hampered by a lack of theoretical frameworks. This paper develops a framework initially stimulated by evidence demonstrating that the cardiovascular system increases in activity during communication, and that the extent of this activation depends upon numerous and diverse psychosocial factors. We attempt to account for this phenomenon using merit post-structuralist ideas concerning the constructive nature of language and its centrality to an individual's sense of self. Our theoretical framework proposes that the CVR exhibited during language use is explicable in terms of self-construction - From this analysis we hypothesised that CVR would differ across conversations about private self. public self and non-self topics, and that these differences would depend upon people's speaking histories. We found that the blood pressure and heart rate of 102 women was most reactive when they talked in a laboratory with a stranger about aspects of their private self, and least reactive during non-self talk, whilst their heart rate was most reactive during talk about their public self. Overall the results highlight the inextricable link between our inherent socialness and our cardiovascular systems. SUMMARY The explanatory scheme outlined here is an attempt to provide a social reconceptualisation of a phenomenon that is typically interpreted in individualistic psychophysiological terms, and which is consistent with the notion that repeated exposure to situations which provoke large haemodynamic changes may lead to CHD disease progression. The explanation draws heavily on post-structuralist ideas regarding language, and the social constructionist notion that engaging in language use is central to constructing and maintaining a sense of self. This sense of self is a central theoretical entity in our everyday lives, produced and maintained in our

  1. Discussing the Safety Application of Chinese Materia Medica in Patients with Cardiovascular Diseases%心血管病患者使用中药安全性探讨

    Institute of Scientific and Technical Information of China (English)

    张俭; 张敏州; 孔祥照


    随着中医药事业的发展,中药在国内外的使用越来越广泛,但是伴随而来的是缺乏安全性证据、自身制作工艺欠成熟、医务人员对毒性认识不足、公众误区等问题的日益严重,尤其对于心血管病患者,因此,需要我们心血管病科医师提高对中药制剂及其作用、副作用的认识,并且要监督及鉴别中药-西药的相互作用,同时要求科研工作者通过严格的实验设计评估中药的安全性和有效性,进一步提高中药的质量、安全性和有效性,严格制定产品说明规范,宣教引导临床医师和普通大众对中药的合理使用.%Along with the development of Chinese medicine and pharmacy ( CMP), Chinese materia medica (CMM) has been used more and more widely at home and abroad. But we have to confront worsening problems such as lack of safety evidence, immature self - formulation technologies, lack of knowledge about their toxicities, and public misunderstanding, especially for patients with cardiovascular disease (CVD). Therefore, we cardiovascular physicians are requested improve knowledge for CMM preparations and their effects and side effects, supervise and identify the interactions between CMM and Western medicine. Meanwhile, the researchers are also requested to assess the safety and efficacy of CMM through rigorous experimental designs, further improve the quality, safety, and efficacy of CMM, strictly formulate the specification of CMM products, guide the rational use of CMM by clinicians and the general public.

  2. Effects of artificial gravity on the cardiovascular system: Computational approach (United States)

    Diaz Artiles, Ana; Heldt, Thomas; Young, Laurence R.


    Artificial gravity has been suggested as a multisystem countermeasure against the negative effects of weightlessness. However, many questions regarding the appropriate configuration are still unanswered, including optimal g-level, angular velocity, gravity gradient, and exercise protocol. Mathematical models can provide unique insight into these questions, particularly when experimental data is very expensive or difficult to obtain. In this research effort, a cardiovascular lumped-parameter model is developed to simulate the short-term transient hemodynamic response to artificial gravity exposure combined with ergometer exercise, using a bicycle mounted on a short-radius centrifuge. The model is thoroughly described and preliminary simulations are conducted to show the model capabilities and potential applications. The model consists of 21 compartments (including systemic circulation, pulmonary circulation, and a cardiac model), and it also includes the rapid cardiovascular control systems (arterial baroreflex and cardiopulmonary reflex). In addition, the pressure gradient resulting from short-radius centrifugation is captured in the model using hydrostatic pressure sources located at each compartment. The model also includes the cardiovascular effects resulting from exercise such as the muscle pump effect. An initial set of artificial gravity simulations were implemented using the Massachusetts Institute of Technology (MIT) Compact-Radius Centrifuge (CRC) configuration. Three centripetal acceleration (artificial gravity) levels were chosen: 1 g, 1.2 g, and 1.4 g, referenced to the subject's feet. Each simulation lasted 15.5 minutes and included a baseline period, the spin-up process, the ergometer exercise period (5 minutes of ergometer exercise at 30 W with a simulated pedal cadence of 60 RPM), and the spin-down process. Results showed that the cardiovascular model is able to predict the cardiovascular dynamics during gravity changes, as well as the expected


    Directory of Open Access Journals (Sweden)

    Sri Endah Rahayuningsih


    Full Text Available Objective: To detect cardiovascular abnormalities in adolescents with chest pain. Methods: In this cross sectional study, the subjects were 25 adolescents with chest pain who came to the Cardiac Center of Dr. Hasan Sadikin General Hospital, Bandung during the period of January 2008 to January 2011. The presence of established cardiovascular disorders were based on history, physical examination, electrocardiography and echocardiography Results: It was found that 13/25 adolescents with chest pain had cardiovascular abnormalities. Of the 25 teens that came with chest pain, most of which showed normal electrocardiographic results, only 9/25 of those with dysrhythmias experienced sinus tachycardia and 8 had a first degree AV block. Echocardiography examination showed only four patients with abnormal cardiac anatomy. No correlation between nutritional status and chest pain, and cardiovascular abnormalities and chest pain (p=0.206 and p=0.632, respectively. There was a positive correlation between sex and cardiovascular abnormalities in adolescents with chest pain (p=0.007. Chest pain is a prevalent problem that is usually benign and that it frequently signals underlying cardiac disease. Conclusions: Cardiovascular abnormalities in adolescents with symptoms of chest pain are found in some cases. There is no correlation between female and male adolescents with chest pain and cardiovascular abnormalities.

  4. Cocoa, blood pressure, and cardiovascular health. (United States)

    Ferri, Claudio; Desideri, Giovambattista; Ferri, Livia; Proietti, Ilenia; Di Agostino, Stefania; Martella, Letizia; Mai, Francesca; Di Giosia, Paolo; Grassi, Davide


    High blood pressure is an important risk factor for cardiovascular disease and cardiovascular events worldwide. Clinical and epidemiological studies suggest that cocoa-rich products reduce the risk of cardiovascular disease. According to this, cocoa has a high content in polyphenols, especially flavanols. Flavanols have been described to exert favorable effects on endothelium-derived vasodilation via the stimulation of nitric oxide-synthase, the increased availability of l-arginine, and the decreased degradation of NO. Cocoa may also have a beneficial effect by protecting against oxidative stress alterations and via decreased platelet aggregation, decreased lipid oxidation, and insulin resistance. These effects are associated with a decrease of blood pressure and a favorable trend toward a reduction in cardiovascular events and strokes. Previous meta-analyses have shown that cocoa-rich foods may reduce blood pressure. Long-term trials investigating the effect of cocoa products are needed to determine whether or not blood pressure is reduced on a chronic basis by daily ingestion of cocoa. Furthermore, long-term trials investigating the effect of cocoa on clinical outcomes are also needed to assess whether cocoa has an effect on cardiovascular events. A 3 mmHg systolic blood pressure reduction has been estimated to decrease the risk of cardiovascular and all-cause mortality. This paper summarizes new findings concerning cocoa effects on blood pressure and cardiovascular health, focusing on putative mechanisms of action and "nutraceutical " viewpoints.

  5. Biomarkers of cardiovascular disease risk in women. (United States)

    Manson, JoAnn E; Bassuk, Shari S


    Cardiovascular disease (CVD), including coronary heart disease and stroke, is the leading cause of death among U.S. women and men. Established cardiovascular risk factors such as smoking, diabetes, hypertension, and elevated total cholesterol, and risk prediction models based on such factors, perform well but do not perfectly predict future risk of CVD. Thus, there has been much recent interest among cardiovascular researchers in identifying novel biomarkers to aid in risk prediction. Such markers include alternative lipids, B-type natriuretic peptides, high-sensitivity troponin, coronary artery calcium, and genetic markers. This article reviews the role of traditional cardiovascular risk factors, risk prediction tools, and selected novel biomarkers and other exposures in predicting risk of developing CVD in women. The predictive role of novel cardiovascular biomarkers for women in primary prevention settings requires additional study, as does the diagnostic and prognostic utility of cardiac troponins for acute coronary syndromes in clinical settings. Sex differences in the clinical expression and physiology of metabolic syndrome may have implications for cardiovascular outcomes. Consideration of exposures that are unique to, or more prevalent in, women may also help to refine cardiovascular risk estimates in this group.

  6. [Cooperative Cardiovascular Disease Research Network (RECAVA)]. (United States)

    García-Dorado, David; Castro-Beiras, Alfonso; Díez, Javier; Gabriel, Rafael; Gimeno-Blanes, Juan R; Ortiz de Landázuri, Manuel; Sánchez, Pedro L; Fernández-Avilés, Francisco


    Today, cardiovascular disease is the principal cause of death and hospitalization in Spain, and accounts for an annual healthcare budget of more than 4000 million euros. Consequently, early diagnosis, effective prevention, and the optimum treatment of cardiovascular disease present a significant social and healthcare challenge for the country. In this context, combining all available resources to increase the efficacy and healthcare benefits of scientific research is a priority. This rationale prompted the establishment of the Spanish Cooperative Cardiovascular Disease Research Network, or RECAVA (Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares), 5 years ago. Since its foundation, RECAVA's activities have focused on achieving four objectives: a) to facilitate contacts between basic, clinical and epidemiological researchers; b) to promote the shared use of advanced technological facilities; c) to apply research results to clinical practice, and d) to train a new generation of translational cardiovascular researchers in Spain. At present, RECAVA consists of 41 research groups and seven shared technological facilities. RECAVA's research strategy is based on a scientific design matrix centered on the most important cardiovascular processes. The level of RECAVA's research activity is reflected in the fact that 28 co-authored articles were published in international journals during the first six months of 2007, with each involving contributions from at least two groups in the network. Finally, RECAVA also participates in the work of the Spanish National Center for Cardiovascular Research, or CNIC (Centro Nacional de Investigación Cardiovascular), and some established Biomedical Research Network Centers, or CIBER (Centros de Investigación Biomédica en RED), with the aim of consolidating the development of a dynamic multidisciplinary research framework that is capable of meeting the growing challenge that cardiovascular disease will present

  7. Perspectives of induced pluripotent stem cells for cardiovascular system regeneration (United States)

    Csöbönyeiová, Mária; Polák, Štefan


    Induced pluripotent stem cells (iPSCs) hold great promise for basic research and regenerative medicine. They offer the same advantages as embryonic stem cells (ESCs) and moreover new perspectives for personalized medicine. iPSCs can be generated from adult somatic tissues by over-expression of a few defined transcription factors, including Oct4, Sox2, Klf4, and c-myc. For regenerative medicine in particular, the technology provides great hope for patients with incurable diseases or potentially fatal disorders such as heart failure. The endogenous regenerative potentials of adult hearts are extremely limited and insufficient to compensate for myocardial loss occurring after myocardial infarction. Recent discoveries have demonstrated that iPSCs have the potential to significantly advance future cardiovascular regenerative therapies. Moreover, iPSCs can be generated from somatic cells of patients with genetic basis for their disease. This human iPSC derivates offer tremendous potential for new disease models. This paper reviews current applications of iPSCs in cardiovascular regenerative medicine and discusses progress in modeling cardiovascular diseases using iPSCs-derived cardiac cells. PMID:25595188

  8. Errors inherent in reconstruction of obscured targets from multilook imagery: I. Background and theory (United States)

    Schmalz, Mark S.


    Automated target recognition has benefited from cross- fertilization of development in related subdisciplines of image processing such as medical imaging. For example, the application of computerized tomography to synthetic aperture radar (SAR) imaging has produced 3-D reconstructions of ground targets on an experimental basis. In practice, by acquiring multiple views of a target (also called multi-look imaging -- MLI) that are subsequently merged mathematically, one can obtain reasonable approximations to higher-dimensional reconstructions of a target of interest. For example, multiple two-dimensional airborne images of ground objects can be merged via the Fourier transform (FT) to obtain one or more approximate three-dimensional object reconstructions. Additional methods of 3D model construction (e.g., from affine structure) present advantages of computational efficiency, but are sensitive to positioning errors. In this series of papers, analysis of MLI is presented that applies to various scenarios of nadir, near-nadir, or off-nadir viewing with a small or large number of narrow-or wide-angle views. A model of imaging through cover describes the visibility of a given target under various viewing conditions. The model can be perturbed to obtain theoretical and simulated predictions of target reconstruction error due to (1) geometric projection error, (2) focal-plane quantization error and camera noise, (3) possible sensor platform errors, and (4) coverage of looks. In this paper, an imaging model is presented that can facilitate prediction of limiting sensor geometry and view redundancy under various imaging constraints (e.g., target and cover geometry, available range of look angles, etc.). Study notation is a subset of image algebra, a rigorous, concise, computationally complete notation that unifies linear and nonlinear mathematics in the image domain. Image algebra was developed at University of Florida over the past decade under the sponsorship of DARPA and

  9. Antioxidants, inflammation and cardiovascular disease. (United States)

    Mangge, Harald; Becker, Kathrin; Fuchs, Dietmar; Gostner, Johanna M


    Multiple factors are involved in the etiology of cardiovascular disease (CVD). Pathological changes occur in a variety of cell types long before symptoms become apparent and diagnosis is made. Dysregulation of physiological functions are associated with the activation of immune cells, leading to local and finally systemic inflammation that is characterized by production of high levels of reactive oxygen species (ROS). Patients suffering from inflammatory diseases often present with diminished levels of antioxidants either due to insufficient dietary intake or, and even more likely, due to increased demand in situations of overwhelming ROS production by activated immune effector cells like macrophages. Antioxidants are suggested to beneficially interfere with diseases-related oxidative stress, however the interplay of endogenous and exogenous antioxidants with the overall redox system is complex. Moreover, molecular mechanisms underlying oxidative stress in CVD are not fully elucidated. Metabolic dybalances are suggested to play a major role in disease onset and progression. Several central signaling pathways involved in the regulation of immunological, metabolic and endothelial function are regulated in a redox-sensitive manner. During cellular immune response, interferon γ-dependent pathways are activated such as tryptophan breakdown by the enzyme indoleamine 2,3-dioxygenase (IDO) in monocyte-derived macrophages, fibroblasts, endothelial and epithelial cells. Neopterin, a marker of oxidative stress and immune activation is produced by GTP-cyclohydrolase I in macrophages and dendritic cells. Nitric oxide synthase (NOS) is induced in several cell types to generate nitric oxide (NO). NO, despite its low reactivity, is a potent antioxidant involved in the regulation of the vasomotor tone and of immunomodulatory signaling pathways. NO inhibits the expression and function of IDO. Function of NOS requires the cofactor tetrahydrobiopterin (BH4), which is produced in

  10. Residual generator for cardiovascular anomalies detection

    KAUST Repository

    Belkhatir, Zehor


    This paper discusses the possibility of using observer-based approaches for cardiovascular anomalies detection and isolation. We consider a lumped parameter model of the cardiovascular system that can be written in a form of nonlinear state-space representation. We show that residuals that are sensitive to variations in some cardiovascular parameters and to abnormal opening and closure of the valves, can be generated. Since the whole state is not easily available for measurement, we propose to associate the residual generator to a robust extended kalman filter. Numerical results performed on synthetic data are provided.

  11. Role of magnesium in cardiovascular diseases. (United States)

    Kolte, Dhaval; Vijayaraghavan, Krishnaswami; Khera, Sahil; Sica, Domenic A; Frishman, William H


    Magnesium, the fourth most abundant cation in the human body, is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. It plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is thus central to the pathogenesis of several cardiovascular disorders such as hypertension, atherosclerosis, coronary artery disease, congestive heart failure, and cardiac arrhythmias. This review discusses the vasodilatory, anti-inflammatory, anti-ischemic, and antiarrhythmic properties of magnesium and its current role in the prevention and treatment of cardiovascular disorders.

  12. Cardiovascular surgery in the elderly: an update

    Institute of Scientific and Technical Information of China (English)

    Song WAN; Ahmed A. ARIFI; Calvin S. H. NG; Anthony P. C. YIM


    The aging of the population and improvements in outcomes after cardiovascular surgery have resulted in a worldwide growing demand of complex surgical intervention for elderly patients. We briefly review the up-to-date English-language literature with particular focus on cardiovascular surgery in elderly patients. With earlier referral, careful preoperative evaluation, strategic planning, and the continuing efforts in optimizing surgical techniques, operative mortality and morbidity following primary or reoperative coronary artery bypass grafting and valvular interventions are expected to fall in this high-risk patient subset. Importantly,accumulating evidence indicates that elderly patients may benefit from improved functional status and quality of life after cardiovascular surgical therapy

  13. Cardiovascular physiology and diseases of amphibians. (United States)

    Heinz-Taheny, Kathleen M


    The class Amphibia includes three orders of amphibians: the anurans (frogs and toads), urodeles (salamanders, axolotls, and newts), and caecilians. The diversity of lifestyles across these three orders has accompanying differences in the cardiovascular anatomy and physiology allowing for adaptations to aquatic or terrestrial habitats, pulmonic or gill respiration, hibernation, and body elongation (in the caecilian). This article provides a review of amphibian cardiovascular anatomy and physiology with discussion of unique species adaptations. In addition, amphibians as cardiovascular animal models and commonly encountered natural diseases are covered.

  14. Cardiovascular reflexes evoked by histamine stimulation of the stomach. (United States)

    Stebbins, C L; Theodossy, S J; Longhurst, J C


    This study examined the potential for histamine to cause cardiovascular reflexes when applied to the serosal or mucosal surface of the stomach. Thus, in chloralose-anesthetized cats, histamine was applied to the serosal surface of the stomach in concentrations ranging from 0.5 to 1,000 micrograms/ml. This resulted in graded increases in mean arterial pressure (MAP), maximal left ventricular pressure over time (dP/dt), and heart rate ranging from 9 +/- 4 to 30 +/- 3 mmHg, 450 +/- 103 to 1,710 +/- 610 mmHg/s, and 2 +/- 1 to 13 +/- 4 beats/min, respectively. Histamine stimulation of the gastric serosa evoked a greater pressor response than that observed when the same concentration of histamine (100 micrograms/ml) was applied to the gastric mucosa (43 +/- 7 vs. 13 +/- 3 mmHg, respectively). In six cats, celiac ganglionectomy abolished the previously observed cardiovascular response to histamine stimulation of the serosal surface of the stomach. When the gastric serosa was treated with the H1-receptor antagonist diphenhydramine (1 mg/ml) (n = 5), the cardiovascular response to histamine was abolished. In five other cats, administration of the H2-antagonist ranitidine (1 mg/ml) had no effect on the histamine-induced responses. When indomethacin (2-5 mg/ml), was applied to the serosal surface of the stomach (n = 6), histamine-induced increases in MAP and dP/dt were attenuated. However, application of PGE2 (1 microgram/ml) restored these two responses. These results suggest that histamine stimulates H1-receptors in the gastric wall to cause reflex cardiovascular responses that are dependent, in part, on the local production of prostaglandins.

  15. Seasonality of cardiovascular risk factors

    DEFF Research Database (Denmark)

    Marti-Soler, Helena; Gubelmann, Cédric; Aeschbacher, Stefanie


    OBJECTIVE: To assess the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies. METHODS: Cross-sectional data from 24 population-based studies from 15 countries, with a total sample size of 237 979 subjects. CVRFs included Body Mass Index (BMI) and waist.......6 cm for waist circumference, 2.9 mm Hg for SBP, 1.4 mm Hg for DBP, 0.02 mmol/L for triglycerides, 0.10 mmol/L for total cholesterol, 0.01 mmol/L for HDL cholesterol, 0.11 mmol/L for LDL cholesterol, and 0.07 mmol/L for glycaemia. Similar results were obtained when the analysis was restricted...... to studies collecting fasting blood samples. Similar seasonal variations were found for most CVRFs in the Southern Hemisphere, with the exception of waist circumference, HDL, and LDL cholesterol. CONCLUSIONS: CVRFs show a seasonal pattern characterised by higher levels in winter, and lower levels in summer...

  16. Globalization, Work, and Cardiovascular Disease. (United States)

    Schnall, Peter L; Dobson, Marnie; Landsbergis, Paul


    Cardiovascular disease (CVD), a global epidemic, is responsible for about 30% of all deaths worldwide. While mortality rates from CVD have been mostly declining in the advanced industrialized nations, CVD risk factors, including hypertension, obesity, and diabetes, have been on the increase everywhere. Researchers investigating the social causes of CVD have produced a robust body of evidence documenting the relationships between the work environment and CVD, including through the mechanisms of psychosocial work stressors. We review the empirical evidence linking work, psychosocial stressors, and CVD. These work stressors can produce chronic biologic arousal and promote unhealthy behaviors and thus, increased CVD risk. We offer a theoretical model that illustrates how economic globalization influences the labor market and work organization in high-income countries, which, in turn, exacerbates job characteristics, such as demands, low job control, effort-reward imbalance, job insecurity, and long work hours. There is also a growing interest in "upstream" factors among work stress researchers, including precarious employment, downsizing/restructuring, privatization, and lean production. We conclude with suggestions for future epidemiologic research on the role of work in the development of CVD, as well as policy recommendations for prevention of work-related CVD.

  17. Cardiovascular Involvement in Autoimmune Diseases

    Directory of Open Access Journals (Sweden)

    Jenny Amaya-Amaya


    Full Text Available Autoimmune diseases (AD represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiological abnormalities, and certain subphenotypes. Atherosclerosis (AT was once considered to be a degenerative disease that was an inevitable consequence of aging. However, research in the last three decades has shown that AT is not degenerative or inevitable. It is an autoimmune-inflammatory disease associated with infectious and inflammatory factors characterized by lipoprotein metabolism alteration that leads to immune system activation with the consequent proliferation of smooth muscle cells, narrowing arteries, and atheroma formation. Both humoral and cellular immune mechanisms have been proposed to participate in the onset and progression of AT. Several risk factors, known as classic risk factors, have been described. Interestingly, the excessive cardiovascular events observed in patients with ADs are not fully explained by these factors. Several novel risk factors contribute to the development of premature vascular damage. In this review, we discuss our current understanding of how traditional and nontraditional risk factors contribute to pathogenesis of CVD in AD.

  18. Cardiovascular benefits of dietary fiber. (United States)

    Satija, Ambika; Hu, Frank B


    The relationship between dietary fiber and risk of cardiovascular disease (CVD) has been extensively studied. There is considerable epidemiological evidence indicating an inverse association between dietary fiber intake and CVD risk. The association has been found to be stronger for cereal fiber than for fruit or vegetable fiber, and several studies have also found increased whole grain consumption to be associated with CVD risk reduction. In light of this evidence, recent US dietary guidelines have endorsed increased consumption of fiber rich whole grains. Regular consumption of dietary fiber, particularly fiber from cereal sources, may improve CVD health through multiple mechanisms including lipid reduction, body weight regulation, improved glucose metabolism, blood pressure control, and reduction of chronic inflammation. Future research should focus on various food sources of fiber, including different types of whole grains, legumes, fruits, vegetables, and nuts, as well as resistant starch in relation to CVD risk and weight control; explore the biological mechanisms underlying the cardioprotective effect of fiber-rich diets; and study different ethnic groups and populations with varying sources of dietary fiber.

  19. Testosterone deficiency and cardiovascular mortality

    Institute of Scientific and Technical Information of China (English)

    Abraham Morgentaler


    New concerns have been raised regarding cardiovascular (CV) risks with testosterone (T) therapy (TTh). These concerns are based primarily on two widely reported retrospective studies. However, methodological flaws and data errors invalidate both studies as credible evidence of risk. One showed reduced adverse events by half in T‑treated men but reversed this result using an unproven statistical approach. The authors subsequently acknowledged serious data errors including nearly 10% contamination of the dataset by women. The second study mistakenly used the rate of T prescriptions written by healthcare providers to men with recent myocardial infarction (MI) as a proxy for the naturally occurring rate of MI. Numerous studies suggest T is beneficial, including decreased mortality in association with TTh, reduced MI rate with TTh in men with the greatest MI risk prognosis, and reduced CV and overall mortality with higher serum levels of endogenous T. Randomized controlled trials have demonstrated benefits of TTh in men with coronary artery disease and congestive heart failure. Improvement in CV risk factors such as fat mass and glycemic control have been repeatedly demonstrated in T‑deficient men treated with T. The current evidence does not support the belief that TTh is associated with increased CV risk or CV mortality. On the contrary, a wealth of evidence accumulated over several decades suggests that low serum T levels are associated with increased risk and that higher endogenous T, as well as TTh itself, appear to be beneficial for CV mortality and risk.

  20. Dietary sodium and cardiovascular disease. (United States)

    Smyth, Andrew; O'Donnell, Martin; Mente, Andrew; Yusuf, Salim


    Although an essential nutrient, higher sodium intake is associated with increasing blood pressure (BP), forming the basis for current population-wide sodium restriction guidelines. While short-term clinical trials have achieved low intake (6 months). Guidelines assume that low sodium intake will reduce BP and reduce cardiovascular disease (CVD), compared to moderate intake. However, current observational evidence suggests a J-shaped association between sodium intake and CVD; the lowest risks observed with 3-5 g/day but higher risk with 5 g/day) and increased risk of CVD. Although lower intake may reduce BP, this may be offset by marked increases in neurohormones and other adverse effects which may paradoxically be adverse. Large randomised clinical trials with sufficient follow-up are required to provide robust data on the long-term effects of sodium reduction on CVD incidence. Until such trials are completed, current evidence suggests that moderate sodium intake for the general population (3-5 g/day) is likely the optimum range for CVD prevention.