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Sample records for cardiovascular agudo shoshin-beriberi

  1. Beriberi cardiovascular agudo (Shoshin-Beriberi Acute cardiovascular beriberi (shoshin-beriberi

    Directory of Open Access Journals (Sweden)

    Osvaldo D. López Gastón

    2002-08-01

    Full Text Available El beriberi, la deficiencia de tiamina (B1, fue referido en el siglo XVII en la literatura asiática, y pue de manifestarse por síntomas neurológicos (beriberi «seco» donde la neuropatía periférica y la debilidad muscular son los más destacados y/o síntomas cardiovasculares (beriberi «húmedo», con una variante «clásica» donde es predominante la insuficiencia cardíaca derecha con índice cardíaco (IC normal o alto y otra aguda o «shoshin-beriberi», caracterizada por insuficiencia biventricular, acidosis láctica e IC variable y que sin tratamiento precoz evoluciona al colapso vascular y la muerte. Se presenta una paciente de 58 años y antecedente de enolismo, con disnea, oliguria, sígnos de fallo cardíaco biventricular con patrón hiperdinámico, acidosis metabólica, disfunción tubular renal y lactacidemia de 5.6 mEq/L. El exámen neurológico mostró una polineuropatía sensitiva, simétrica y distal en MMII y deterioro cognitivo con sígnos frontales. Horas después de la administración de 100 mg de tiamina ev. se observó una manifiesta mejoría de los valores hemodinámicos y el estado ácido-base. Se concluye que si bien el beriberi cardiovascular agudo es de presentación infrecuente hay consenso en que además es subdiagnosticado. La presencia de acidosis láctica o cuadro de insuficiencia cardíaca de alto volumen minuto sin etiología manifiesta, en pacientes con riesgo de deficiencia de B1, es suficiente para hacer la prueba terapéutica.Beriberi (BB, thiamine deficiency, has been described in the Asian literature in the 17th century and is characterized by peripheral neuropathy and muscle weakness, also called «dry» beriberi (BB to differentiate it from «wet» BB, with essentially cardiovascular manifestations. Wet can be either «classic» wet BB in which signs and symptons of right-sided heart failure with normal or high cardiac output are the presenting features or the «shoshin» BB variant with severe

  2. Shoshin Beriberi Induced by Long-Term Administration of Diuretics: A Case Report

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    Naoki Misumida

    2014-01-01

    Full Text Available Previous studies have suggested that diuretic therapy for heart failure may lead to thiamine deficiency due to the increased urinary thiamine excretion. Herein, we present the case of a 61-year-old man with shoshin beriberi, a fulminant form of wet beriberi, induced by long-term diuretic therapy. The patient had a history of heart failure with preserved ejection fraction and was receiving furosemide and trichlormethiazide therapy. He presented with worsening exertional dyspnea and was admitted for heart failure exacerbation. His condition failed to improve even after intensive treatment. A hemodynamic evaluation with the Swan-Ganz catheter revealed high-output heart failure with low peripheral vascular resistance. Thiamine was administered for suspected shoshin beriberi; his hemodynamic status improved dramatically within the next six hours. The serum thiamine level was below the normal range; the patient was therefore diagnosed with shoshin beriberi. The common causes of thiamine deficiency were not identified. Long-term diuretic therapy with furosemide and thiazide was thought to have played a major role in the development of thiamine deficiency. This case illustrates the importance of considering wet beriberi as a possible cause of heart failure exacerbation in patients taking diuretics, even when the common thiamine deficiency causes are not identified with history-taking.

  3. Shoshin beriberi-thiamine responsive pulmonary hypertension in exclusively breastfed infants: A study from northern India.

    Science.gov (United States)

    Bhat, Javeed Iqbal; Rather, Hilal Ahmad; Ahangar, Ambreen Ali; Qureshi, Umar Amin; Dar, Parvez; Ahmed, Qazi Iqbal; Charoo, Bashir Ahmed; Ali, Syed Wajid

    To study the effect of thiamine administration on the resolution of pulmonary hypertension in exclusively breastfed infants. Prospective cohort study. Hospital based study of a tertiary care hospital. A total of 29 infants with 17 males (58.6%) and 12 females (41.4%) were included in the study. In addition to the management of shock, right heart failure and renal failure, patients received intravenous thiamine 100mg/kg IV followed by 10mg/day till introduction of supplementary feeds. Resolution of shock, metabolic complications and pulmonary hypertension. Mean age at presentation was 78.45±30.7 days. All infants were exclusively breastfed. 86.2% of mothers were on customary dietary restrictions. Biventricular failure and tachycardia was commonly present. There were four deaths in our series. Acute metabolic acidosis was a universal feature with a mean pH of 7.21±0.15. Pulmonary hypertension was present in all patients on admission. Intravenous thiamine 100mg/kg IV stat was given immediately after documenting pulmonary hypertension. Repeat echocardiography showed complete resolution of pulmonary hypertension. Many infants present to us with Shoshin beriberi with unusually high pulmonary pressures. These patients respond to thiamine challenge with prompt resolution of metabolic complications and reversal of pulmonary hypertension. We believe this is first of its kind from the region, which is reported. Copyright © 2016. Published by Elsevier B.V.

  4. Efeitos cardiovasculares agudos do exercício resistido em idosas hipertensas = Cute cardiovascular effects of resistence exercise on hypertensive elderly women

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    Kleverton Krinski

    2008-07-01

    Full Text Available O objetivo deste estudo foi avaliar os efeitos cardiovasculares agudos do exercício resistido (ER em idosas com hipertensão estágio I. Participaram 24 hipertensas (63,7 ± 3,7 anos, submetidas a uma sessão de ER, constituída por oito estações (três séries,12 repetições, 50% 1 RM. A frequência cardíaca (FC, a pressão arterial sistólica (PAS e a diastólica (PAD foram mensuradas anteriormente ao início dos exercícios (A, imediatamente após a quinta estação (B e 10 min. após a sessão de exercícios (C. Anova demedidas repetidas e post-hoc Tukey (p The aim of this study was to evaluate the effect of acute cardiovascular responses of resistance exercise (RE on stage I hypertensive elderly women. Twenty four hypertensive women (63.7 ± 3.7 years were subjected a session of RE, with eight stations(3 sets, 12 repetitions, 50% 1 RM. The heart rate (HR, systolic blood pressure (SBP and blood pressure (DBP were measured before the exercise sessions (A, immediately after the fifth station (B, and 10 minutes after the exercise sessions (C. Repeated measuresAnova and post-hoc Tukey test (p < 0.05 were performed. The results demonstrated significant increase in SBP, DBP and HR (p < 0.05 between the A and B conditions. Subsequently, SBP and DBP decreased significantly for the C condition as compared to the B condition (p < 0.05; however, only DBP decreased significantly for the A condition (p < 0.05. Although the results demonstrated that acute cardiovascular modifications are associated with RE, hypotensive effects were only verified on DBP.

  5. Fisiopatología del dolor agudo: alteraciones cardiovasculares, respiratorias y de otros sistemas y órganos

    OpenAIRE

    Pérez-Castañeda Jorge, Tania

    2012-01-01

    Introducción: El dolor agudo constituye una compleja constelación de experiencias sensoriales y emocionales, relacionadas con respuestas autónomas producidas por daño a estructuras somáticas o viscerales. Las vías del dolor transmiten la información nociceptiva a través del sistema nervioso periférico y central y están plenamente integradas con el sistema motor y simpático a nivel medular y de los centros nerviosos superiores y dan lugar a actividad motora refleja, hiperactividad simpática y ...

  6. Desempeño Cardiovascular de Dos Estirpes de Gallus gallus domesticus Sometidas a Estrés Calórico Agudo

    DEFF Research Database (Denmark)

    Chacon, Tony; De Basilio, Vasco; Zerpa, Hector

    2015-01-01

    Genetic selection in poultry has been based on fast growth characters and not on stress adaptability. This investigation assessed cardiovascular variables in two lineages of Gallus gallus domesticus of different domestication levels, subjected to acute heat stress. To carry out the assay, broiler...

  7. O efeito agudo do chocolate amargo sob a função endotelial é dependente da idade em hipertensos com baixo risco cardiovascular

    OpenAIRE

    Jenifer Palma dEl-Rei Pinto

    2011-01-01

    Dados recentes indicam uma relação inversa entre doença cardiovascular e consumo de flavonóides. O objetivo do estudo foi identificar parâmetros clínicos e vasculares de pacientes hipertensos tratados que apresentaram efeitos benéficos na função vascular após o consumo de chocolate amargo com 70% de cacau por sete dias. Vinte e um pacientes hipertensos em tratamento medicamentoso, ambos os sexos, com idades entre 40-65 anos, foram incluídos em um ensaio clínico intervencional com aferição de...

  8. Agregación familiar del riesgo cardiovascular. Estudio realizado en familiares de primer y segundo grado de pacientes con infarto agudo de miocardio

    OpenAIRE

    Blanco Blanco, María Dolores

    2012-01-01

    Tesis Publicada con ISBN: 978-84-606-8138-0 Las enfermedades cardiovasculares (ECV) son la principal causa de mortalidad en los países desarrollados, suponiendo, según la OMS, algo más de 17 millones de fallecimientos al año. Son una fuente importante de discapacidad, contribuyendo en gran medida al aumento en los costes de la asistencia sanitaria. Aunque en su etiología concurren numerosos factores, la principal causa subyacente es la aterosclerosis, proceso inflamatorio crónico intra...

  9. Efeitos cardiovasculares agudos do exercício resistido em idosas hipertensas - DOI: 10.4025/actascihealthsci.v30i2.428 Cute cardiovascular effects of resistence exercise on hypertensive elderly women - DOI: 10.4025/actascihealthsci.v30i2.428

    Directory of Open Access Journals (Sweden)

    Wagner de Campos

    2008-12-01

    Full Text Available O objetivo deste estudo foi avaliar os efeitos cardiovasculares agudos do exercício resistido (ER em idosas com hipertensão estágio I. Participaram 24 hipertensas (63,7 ± 3,7 anos, submetidas a uma sessão de ER, constituída por oito estações (três séries, 12 repetições, 50% 1 RM. A frequência cardíaca (FC, a pressão arterial sistólica (PAS e a diastólica (PAD foram mensuradas anteriormente ao início dos exercícios (A, imediatamente após a quinta estação (B e 10 min. após a sessão de exercícios (C. Anova de medidas repetidas e post-hoc Tukey (p The aim of this study was to evaluate the effect of acute cardiovascular responses of resistance exercise (RE on stage I hypertensive elderly women. Twenty four hypertensive women (63.7 ± 3.7 years were subjected a session of RE, with eight stations (3 sets, 12 repetitions, 50% 1 RM. The heart rate (HR, systolic blood pressure (SBP and blood pressure (DBP were measured before the exercise sessions (A, immediately after the fifth station (B, and 10 minutes after the exercise sessions (C. Repeated measures Anova and post-hoc Tukey test (p < 0.05 were performed. The results demonstrated significant increase in SBP, DBP and HR (p < 0.05 between the A and B conditions. Subsequently, SBP and DBP decreased significantly for the C condition as compared to the B condition (p < 0.05; however, only DBP decreased significantly for the A condition (p < 0.05. Although the results demonstrated that acute cardiovascular modifications are associated with RE, hypotensive effects were only verified on DBP.

  10. Terapéutica del dolor agudo

    OpenAIRE

    Alonso Babarro, Alberto

    2006-01-01

    El abordaje del dolor agudo en la práctica clínica debe empezar siempre por una correcta valoración. La evaluación debe incluir tanto la investigación sobre el probable origen del dolor, sus características y su mecanismo fisiopatológico como la determinación de la intensidad del dolor para facilitarnos el control del tratamiento propuesto. Numerosos trabajos han evaluado mediante revisiones sistemáticas la utilidad de los diferentes tratamientos en los distintos cuadros de dolor agudo. A par...

  11. Doença periodontal e infarto agudo do miocardio

    OpenAIRE

    Coelho, Julita Maria Freitas

    2010-01-01

    p. 1-98 Dados epidemiológicos, experimentais e clínicos têm sugerido que a doença periodontal, especialmente a periodontite crônica, pode constituir um fator de risco para doenças cardiovasculares isquêmicas. A proposta deste estudo foi investigar a associação entre a doença periodontal e o infarto agudo do miocárdio (IAM) em indivíduos adultos. Uma revisão de literatura de estudos de caso-controle que estudaram essa associação foi sumarizada em uma meta-análise que demonstrou uma chance e...

  12. Trombolisis en el infarto agudo del miocardio en servicio de emergencias

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    Alexander del Toro Cámbara

    2013-12-01

    Full Text Available Introducción: las enfermedades cardiovasculares y dentro de estas, el infarto agudo del miocardio han sido el mayor problema de salud y la principal causa de muerte en muchos países del mundo durante varias décadas. Objetivo: determinar la efectividad de la estreptoquinasa recombinante cubana en la morbilidad y mortalidad del infarto agudo del miocardio. Material y método: se realizó una investigación observacional, descriptiva y transversal en los pacientes con diagnóstico de Infarto Agudo del Miocardio, que acudieron al servicio de emergencias del Policlínico Universitario Pedro Borrás, entre septiembre 2009 y agosto 2010. El universo lo integraron 56 pacientes con síndrome coronario agudo con elevación del ST, y la muestra 42 pacientes trombolizados. Las técnicas de procesamiento y análisis fueron la distribución en frecuencias absolutas y relativas y la prueba de ji cuadrado. Resultados: predominaron los pacientes del sexo masculino y edades comprendidas entre 45 y 60 años. Prevaleció la implantación del tratamiento por debajo de las seis horas, siendo tratados un número pequeño de pacientes durante la primera hora, efectiva en todos los casos. Sobresalieron como reacciones adversas la hipotensión arterial y las contracciones auriculares y ventriculares prematuras. Preponderó la desaparición del dolor y regresión de los cambios isquémicos electrocardiográficos como criterios de reperfusión. Conclusiones: el uso de la estreptoquinasa recombinante cubana contribuyó a disminuir la mortalidad en pacientes con infarto agudo al miocardio quedando así demostrado su efectividad.

  13. Nuevos antiagregantes plaquetarios en síndrome coronario agudo

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    Andrés F Buitrago

    2013-06-01

    Full Text Available En la actualidad las enfermedades cardiovasculares son la principal causa de muerte en los países industrializados y para 2020, lo serán en países en vía de desarrollo. El síndrome coronario agudo se caracteriza por la ruptura o erosión de una placa aterosclerótica que trae consigo grados variables de trombosis y embolización distal, que llevan a una disminución en la perfusión miocárdica. Posterior a la disrupción vascular, empieza un proceso de agregación, activación y adhesión plaquetaria que inicia la formación del trombo mural. Dado que el primer paso en la formación del trombo coronario involucra la activación y la agregación plaquetaria, el tratamiento con medicamentos antiplaquetarios es una de las piedras angulares del síndrome coronario agudo. La antiagregación dual con ácido acetil salicílico y un inhibidor del receptor P2Y12, hacen parte del manejo actual de los pacientes con síndrome coronario agudo y de aquellos sometidos a intervención coronaria percutánea. El clopidogrel es el inhibidor del receptor P2Y12 más utilizado; sin embargo, sus beneficios clínicos se ven limitados por varios factores que interfieren con la conversión del medicamento a su metabolito activo. Es por esto que recientemente se han desarrollado nuevos inhibidores del receptor P2Y12, como prasugrel y ticagrelor, con un efecto antiplaquetario más potente y mayores beneficios clínicos. Las actualizaciones recientes de las guías de manejo basadas en la evidencia los han incluido como parte del tratamiento de esta patología con un grado de recomendación incluso mayor que el de clopidogrel.

  14. Infarto agudo de miocardio inducido por heroína

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    Beatriz Wills

    2014-09-01

    Full Text Available El uso mundial de drogas recreativas ha alcanzado proporciones preocupantes, al punto de amenazar la estabilidad socioeconómica de los países. Se estima que en los países desarrollados una de cada 4 personas ha utilizado drogas recreativas en algún momento de su vida. Por tanto, es frecuente que los médicos se enfrenten a cuadros de intoxicación secundaria al abuso de estas drogas. Además de sus efectos en el sistema nervioso central, también producen cambios significativos a nivel cardiovascular, responsables de una cantidad no despreciable de morbimortalidad relacionada con estas. En este artículo se expone un caso de infarto agudo de miocardio secundario al consumo de heroína, se revisan los efectos sistémicos de esta droga y se examinan el manejo y los mecanismos estudiados que explican esta relación.

  15. Edema pulmonar agudo neurogênico: relato de caso

    OpenAIRE

    Brito,José Correia De Farias; Diniz,Maria Cerly Almeida; Rosas,Roberto Ramalho; Silva,José Alberto Gonçalves Da

    1995-01-01

    Os autores apresentam um caso de edema pulmonar agudo numa paciente de 28 anos de idade acometida de hemorragia subaracnóidea secundária à rotura de aneurisma intracraniano. A sintomatologia respiratória ocorreu durante o agravamento do quadro neurológico. Alguns aspectos etiológicos e fisiopatogênicos do edema pulmonar agudo neurogênico são analisados.

  16. Factores relacionados con la mortalidad intrahospitalaria en el infarto agudo del miocardio

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    Yanier Coll Muñoz

    2012-09-01

    Full Text Available Fundamento: la identificación de los factores relacionados con la mortalidad en el infarto agudo del miocardio representa un eslabón primordial en la evaluación inicial de los pacientes. Objetivo: identificar los factores relacionados con la mortalidad intrahospitalaria de los pacientes con infarto agudo del miocardio, ingresados en la Unidad de Cuidados Intensivos Coronarios de Cienfuegos durante el año 2010. Método: se realizó un estudio de serie de casos, que incluyó 241 pacientes con diagnóstico de infarto agudo del miocardio, ingresados en la Unidad de Cuidados Intensivos Coronarios del Hospital General Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos, en el año 2010. Las variables que se analizaron fueron: edad, sexo, antecedentes patológicos personales, tipo de infarto agudo del miocardio (según electrocardiograma y localización topográfica, frecuencia cardiaca y tensión arterial al ingreso, clasificación de la insuficiencia cardiaca según Killip Kimball, creatinina, glicemia, colesterol total, triglicéridos, CPK-MB, y eventos adversos cardiovasculares durante su estadía hospitalaria. Resultados: la edad media de los pacientes estudiados fue de 65,6 años, con predominio del sexo masculino. La hipertensión arterial, el tabaquismo y el infarto miocárdico previo fueron los antecedentes de mayor interés, predominan los pacientes sin insuficiencia cardiaca y fracción de eyección conservada. Los eventos adversos cardiovasculares más frecuentes fueron: la angina post-infarto, arritmias ventriculares malignas y el choque cardiogénico. Conclusiones: se encontró relación significativa con la mortalidad para la edad avanzada (>70 años, taquicardia, glicemia ≥7 mmol/l al ingreso, y la presentación de arritmias ventriculares y choque cardiogénico durante la evolución intrahospitalaria.

  17. Infarto Miocárdico Agudo: una perspectiva desde la Atención Primaria de Salud

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    Lianne Ramos Marrero

    Full Text Available Introducción: las enfermedades del corazón constituyen la primera causa de muerte a nivel mundial. Durante más de cuatro décadas, Cuba comportó similar estadística hasta el año 2012, a partir del cual el cáncer se situó como la primera causa de muerte; no obstante la enfermedades cardiovasculares constituyen un problema de salud de segundo orden para Cuba y dentro de este ítem el infarto miocárdico agudo como la principal causa de muerte. Objetivo: profundizar en el conocimiento sobre los elementos diagnósticos y de la conducta ante un infarto miocárdico agudo en el nivel primario de atención. Desarrollo: se hace especial énfasis en los elementos diagnósticos y la conducta recomendada ajustada a las posibilidades del nivel primario de atención. Conclusiones: el Infarto miocárdico agudo aporta la mayor mortalidad dentro de las enfermedades cardiacas, de causa multifactorial, su diagnóstico en la atención primaria de salud se basa en el cuadro clínico y cambios electrocardiográficos. La trombólisis es piedra angular en el tratamiento temprano de reperfusión.

  18. Hiperglucemia en el síndrome coronario agudo: informe científico multidisciplinario

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    Patricia Blanco

    2012-04-01

    Full Text Available La hiperglucemia con o sin diabetes preexistente es un hallazgo frecuente en pacientes que cursan un síndrome coronario agudo. Estudios previos han demostrado que la hiperglucemia es altamente prevalente y se asocia a un mayor riesgo de muerte y complicaciones hospitalarias. Los mecanismos fisiopatológicos mediante los cuales la hiperglucemia provoca resultados adversos no son claros, y se desconoce si es un marcador de eventos o su causa. Los efectos perjudiciales de la hiperglucemia en el sistema cardiovascular son múltiples, y el control de los niveles de glucosa con insulina parece mejorar el pronóstico en estos pacientes. Se han desarrollado numerosos protocolos para el control de glucemia que demostraron ser seguros y efectivos. En una iniciativa originada en el Consejo de Emergencias de la Sociedad Argentina de Cardiología, se convocó a expertos de nuestro medio con el propósito de debatir estrategias para el control de la glucemia en pacientes que cursan un síndrome coronario agudo. Este documento refleja lo discutido en este evento académico con la intención de resumir los principales aspectos del control de la glucemia y ofrecer recomendaciones generales de tratamiento en la Unidad Coronaria.

  19. Comunicación interventricular post infarto agudo del miocardio

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    Fabián A. Ruiz, MD

    2013-11-01

    En este artículo se expone el caso de un paciente con síndrome coronario agudo sin terapia de reperfusión inicial, con posterior ruptura del septum interventricular, en quien se evidenció la utilidad de la ecocardiografía en el diagnóstico de dicha entidad.

  20. Oxcarbazepina para los episodios afectivos agudos en el trastorno bipolar

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    Akshya Vasudev

    2012-09-01

    Se necesitan ensayos controlados con asignación aleatoria con adecuado poder estadístico y de buena calidad metodológica para informar el potencial terapéutico de la oxcarbazepina a través del espectro de episodios agudos en el trastorno bipolar.

  1. Manejo prehospitalario del síndrome coronario agudo

    OpenAIRE

    Borrego Alfaraz, Cristina

    2017-01-01

    [EN] La cardiopatía isquémica, concretamente el síndrome coronario agudo, es una de las principales causas de mortalidad a nivel mundial. Además, con el envejecimiento de la población, su incidencia aumentará en las próximas décadas. Es por ello por lo que el conocimiento sobre este tema y la mejora en su abordaje se tornan imprescindibles. De esta manera, el manejo prehospitalario del síndrome coronario agudo se caracteriza por su rápida detección a través de la interpretación de un el...

  2. Presencia y severidad de calcio coronario: su relación con la aparición de eventos coronarios agudos

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    Lázaro E. de la Cruz Avilés

    2012-03-01

    Full Text Available Fundamento: la detección de calcio en las arterias coronarias confirma la presencia de aterosclerosis y ha demostrado ser una herramienta útil para estratificar el riesgo cardiovascular. Objetivo: determinar la relación entre la presencia y severidad de calcio coronario con la aparición de eventos coronarios agudos. Métodos: se realizó un estudio observacional, descriptivo, prospectivo, tipo serie de casos, en el Hospital Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos, entre enero y diciembre de 2008. La serie estuvo conformada por 137 pacientes, en los que se estudió: sexo, antecedentes patológicos personales, cifras de glucemia en ayunas, creatinina, colesterol total y triglicéridos. Los pacientes fueron seguidos durante dos años para evaluar la aparición de eventos coronarios agudos. Resultados: La edad media fue de 53,2±7,4 años, con predominio del sexo masculino (52,5 %. El mayor porciento de pacientes clasificados como de alto riesgo, según la cuantificación del calcio coronario (16,8 % perteneció al sexo masculino, predominando en los mayores de 70 años. La diabetes se relacionó de forma significativa con la severidad del puntaje de calcio. El infarto agudo del miocardio fue más frecuente en pacientes con puntaje de calcio mayor de 400 unidades Agatston. Conclusiones: la aparición de eventos coronarios agudos fue más frecuente en los pacientes de alto riesgo según cuantificación del calcio coronario.

  3. Impacto Pronóstico de los Síndromes Geriátricos en Pacientes Ancianos con Síndrome Coronario Agudo

    OpenAIRE

    Bonanad Lozano, Clara

    2015-01-01

    Los síndromes geriátricos pueden predecir eventos adversos en el contexto del síndrome coronario agudo más allá de la propia edad y de los clásicos factores de riesgo cardiovascular. El objetivo de la presente tesis doctoral fue cuantificar y evaluar un amplio espectro de síndromes geriátricos en pacientes supervivientes a la fase aguda de un síndrome coronario. Se incluyeron un total de 342 pacientes mayores de 65 años que ingresaron de forma consecutiva en el servicio de Cardiología de un ú...

  4. El sólido hiperbólico agudo

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    Rosa María Herrera

    2012-04-01

    Full Text Available Torricelli consideró el cálculo del volumen de sólido hiperbólico agudo como el mejor logro en sus trabajos con ‘indivisibles curvos’. Fue publicado en la Opera geometrica. Aquí se presenta como muestra del estilo de las demostraciones matemáticas (geométricas que se efectuaban en el siglo XVII, y por su valor precursor del cálculo infinitesimal. Es un ejemplo significativo para aproximarse al pensamiento torricelliano.

  5. Estado Confusional Agudo nas Unidades de Cuidados Intensivos

    OpenAIRE

    Santos, L; Alcântara, J

    1996-01-01

    As alterações do comportamento frequentemente observadas em doentes internados nas unidades de cuidados intensivos (UCI), podem ser adequadamente designadas, na maioria das vezes, por estado confusional agudo, o qual se caracteriza por: flutuação do estado de vigília, distúrbio do ciclo vigília-sono, défice de atenção e concentração, desorganização do pensamento, manifestado entre outras formas por discurso incoerente, distúrbios da percepção sob a forma de ilusões e/ou alucinações, desorient...

  6. Trastornos psiquiátricos frecuentes post infarto agudo al miocardio y su relación pronóstica. Revisión de la literatura.

    Directory of Open Access Journals (Sweden)

    Manuel Mallol Simmonds

    2017-07-01

    Full Text Available La enfermedad cardiovascular es la principal causa de muerte a nivel mundial. De ella, el Infarto Agudo al Miocardio (IAM y el Accidente Cerebrovascular (AVC se encuentran fuertemente asociados a los cambios ambientales y sociales del último tiempo, tales como aumento de ingesta de comida rápida, sedentarismo, tabaquismo, entre otros. Algunos trastornos psiquiátricos que aparecen a corto y largo plazo posterior al evento coronario agudo tienen una implicancia directa en la morbimortalidad cardiovascular y global. De ellos, la depresión representa el trastorno psiquiátrico más frecuente, pudiendo encontrarse en 3 de cada 10 pacientes que tuvieron un IAM. La depresión aumenta las hospitalizaciones, disminuye la adherencia terapéutica y empeora el pronóstico cardiovascular a largo plazo.  La fisiopatología en lo anterior es explicada en parte por alteraciones en el eje neuroendocrino y la respuesta al estrés, mientras que otros fenómenos permanecen aún desconocidos. Dentro de otros trastornos psiquiátricos asociados a un IAM se encuentran el delirium, ansiedad y trastornos de la personalidad. En función de lo anterior, se hace necesaria la incorporación de un sistema continuo de monitoreo y apoyo en salud mental en este grupo de pacientes para mejorar tanto su pronóstico como la calidad de vida.

  7. Tratamiento del dolor agudo en el paciente dependiente de sustancias

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    DR. B. Juan Pablo Acuña

    2014-07-01

    Full Text Available El manejo del dolor agudo del paciente dependiente de sustancias, es un desafío para el profesional encargado de otorgar alivio a su síntoma. La dependencia de sustancias es reconocida como una enfermedad cerebral primaria crónica y recurrente. Su neurobiología y mecanismos fisiopatológicos de adaptación a la sustancia generan cambios en la percepción del dolor, en la respuesta a analgésicos opioides y cambios conductuales que interfieren con el tratamiento del dolor. Un conocimiento básico y claro respecto de lo descrito permite diseñar estrategias seguras y eficaces de alivio del dolor, sin interferir el curso de la enfermedad adictiva. Artículos de revisión, recomendaciones y guías elaboradas por expertos coinciden en que el tratamiento más eficaz del dolor incluye un manejo multimodal, un enfoque multidisciplinario, mantención de la terapia de sustitución y una estrecha vigilancia durante el episodio agudo de dolor y su seguimiento posterior.

  8. Troponina T vs Troponina I como Valor Predictivo para Síndrome Coronario Agudo en menores de 80 Años

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    PE Pla Cala

    2015-07-01

    Full Text Available Resumen – Actualmente en la injuria miocárdica, ha tenido gran relevancia clínica la utilidad de las troponinas como método diagnóstico, repercutiendo en el manejo del síndrome coronario agudo. Objetivo: Analizar la importancia de los biomarcadores troponina T e I y otros elementos adyuvantes que cumplen un papel trascendental como es el electrocardiograma y los diferentes métodos invasivos, el cual brinda una orientación para la concepción de un diagnóstico oportuno que permita tomar las acciones pertinentes en un paciente con síndrome coronario agudo. Materiales y Métodos: Estudio descriptivo comparativo en 35 pacientes, adultos mayores de 21 años y menores 80 años, que se encontraban hospitalizados en la Empresa Social del Estado Centro de Atención y Rehabilitación Integral - E.S.E CARI de Alta complejidad, en el periodo comprendido entre el año 2012 a 2014. Resultados: Los pacientes presentaron síndrome coronario agudo (infarto agudo de miocardio con o sin elevación del ST, con factores de riesgo cardiovascular tales como: sedentarismo, tabaquismo, hipertensión arterial, diabetes, valvulopatías, dislipidemia y antecedentes de cardiopatía isquémica. El punto a analizar fue la elevación de los biomarcadores troponina T y troponina I en un periodo menor y mayor a 3 horas, desde el inicio de los síntomas (dolor torácico, criodiaforesis, disnea hasta el ingreso a la institución hospitalaria. Se compararon los resultados obtenidos de cada uno de estos biomarcadores en el diagnóstico precoz y oportuno del síndrome coronario agudo. De las muestra analizada (n=35 pacientes se obtuvo que la troponina T< 3 horas se elevó un 76.4% en rangos de edad entre los 60-80 años en contraste con troponina I < 3 horas en ese mismo grupo etario que fue de 70.5%. Conclusiones: se evidenció que ambos biomarcadores son equiparables con una ligera ventaja de la troponina T con respecto a la I.

  9. Efeitos do exercicio agudo sobre biomarcadores sericos de ratos diabeticos

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    Fabio Milioni

    2014-01-01

    Full Text Available INTRODUÇÃO: As respostas ao exercício agudo dos biomarcadores, como a fosfatase alcalina (FA e a creatina quinase (CK séricas têm sido pouco investigadas em ratos diabéticos. OBJETIVOS: Verificar os efeitos do exercício físico aeróbio agudo sobre as concentrações de CK e FA, bem como, avaliar o estado hídrico em ratos diabéticos experimentais. MATERIAIS E MÉTODOS Foram utilizados ratos Wistar machos, adultos jovens, distribuídos em dois grupos: diabéticos (DA e controles (CA. O diabetes foi induzido por meio da administração de aloxana monoidratado Sigma(r (32 mg/kg de peso corporal. Duas semanas após confirmação do diabetes, ambos os grupos foram submetidos a uma sessão aguda de natação por 30 min, com carga aeróbia (4,5 % do peso corporal. Foram avaliados: glicose, hematócrito, CK, FA, albumina e a cinética de lactato durante o exercício por meio de coletas 25 µL de sangue da cauda dos animais, nos minutos 0, 10, 20 e 30 de exercício. RESULTADOS: ANOVA de dois fatores para medidas repetidas e o teste post hoc de Tukey apontaram diminuição significativa dos valores de glicemia após o exercício para o grupo DA, aumento significativo de CK pós-exercício para o grupo DA, aumento significativo de hematócrito para ambos os grupos após exercício e manutenção da FA após exercício para o grupo DA. CONCLUSÃO: O exercício agudo aeróbio foi eficiente no controle dos níveis glicêmicos de ratos diabéticos. Entretanto, deve ser aplicado com cautela, pois induziu altos valores de CK, sugerindo possíveis lesões teciduais.

  10. Efeitos agudos da corrente interferencial ganglionar em mulheres sadias

    OpenAIRE

    Nakata, Cláudio Hiroshi

    2014-01-01

    OBJETIVO: Analisar os efeitos agudos da corrente interferencial ganglionar em mulheres sadias. MATERIAIS E MÉTODOS: Estudo do tipo experimental aleatorizado e transversal. Vinte e uma mulheres militares do Exército Brasileiro divididas em dois grupos, conforme IPAQ, em ativas (média de idade de 32,80 ± 3,011 anos, massa 56,50 ± 5,523 Kg, estatura de 164,30 ± 6,993 cm e IMC de 20,90 ± 1,729 kg/m2 e 80% com conceito excelente no teste de aptidão física) e irregularmente ativas (média de idade d...

  11. Síndrome coronario agudo con supradesnivel del ST asociado al feocromocitoma con las catecolaminas inicialmente normales

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    Jorge M. Pacheco

    2016-01-01

    Full Text Available Los feocromocitomas son tumores secretores de catecolaminas que cursan con paroxismos de hipertensión o hipotensión arterial y palpitaciones. Son una causa rara del síndrome coronario agudo. Presentamos el caso de una paciente con síndrome coronario agudo secundario a feocromocitoma que inicialmente tenía valores normales de catecolaminas.

  12. Síndrome coronario agudo con supradesnivel del ST asociado al feocromocitoma con las catecolaminas inicialmente normales

    OpenAIRE

    Pacheco, Jorge M.; Pérez Baztarrica, Gabriel; Díaz Bozio, Fernando; Jiménez, Andrés; Porcile, Rafael

    2016-01-01

    Los feocromocitomas son tumores secretores de catecolaminas que cursan con paroxismos de hipertensión o hipotensión arterial y palpitaciones. Son una causa rara del síndrome coronario agudo. Presentamos el caso de una paciente con síndrome coronario agudo secundario a feocromocitoma que inicialmente tenía valores normales de catecolaminas.

  13. Abdomen agudo quirúrgico en el anciano

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    Jesús M Valdés Jiménez

    2002-04-01

    Full Text Available Se presenta un estudio descriptivo retrospectivo de 156 enfermos mayores de 65 años, con diagnóstico de abdomen agudo quirúrgico (AAQ, operados en el Hospital Clinicoquirúrgico «Manuel Fajardo» e ingresados en la Unidad de Cuidados Intermedios Polivalente, durante el trienio comprendido entre 1995 y 1998. Las causas más frecuentes del síndrome fueron la oclusión intestinal (58,9 %, la colecistitis aguda (13,5 % y la úlcera péptica gastroduodenal perforada (10,9 %. Las enfermedades asociadas de mayor prevalencia eran la cardiopatía isquémica (62,2 % y la hipertensión arterial (48,7 %. La mortalidad aumentó con el avance de la edad, y alcanzó el 70,4 % en los mayores de 85 años. Entre las complicaciones predominaron la infección de la herida quirúrgica (12,8 % y la bronconeumonía (5,8 %. La principal causa de muerte fue la sepsis (10,3 %A descriptive and retrospective study of 156 patients over 65 with diagnosis of acute surgical abdomen (ASA that were operated on at "Manuel Fajardo" Clinical and Surgical Hospital and admitted at the Polyvalent Intermediate Care Unit, from 1995 to 1998, was conducted. The most common causes of the syndrome were intestinal occlusion (58.9 %, acute cholecystitis (13.5 % and the gastroduodenal perforated peptic ulcer (10.9 %. The associated diseases of highest prevalence were ischemic heart disease (62.2 % and arterial hypertension (48.7 %. Mortality increased with age and amounted to 70.4 % in patients over 85. The infection of the surgical wound (12.8 % and bronchopneumonia (5.8% prevailed among the complications. Sepsis (10.3 % was the main cause of death

  14. Abdome agudo por obstrução por ileobiliar

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    Márcia Cristina de Alencastro

    Full Text Available OBJETIVO: descrever a experiência na abordagem dos doentes com abdome agudo por obstrução por IB, desde o diagnóstico até o tratamento definitivo. MÉTODOS: estudo retrospectivo incluindo todos os casos de IB tratados em um período de 23 anos. De acordo com a abordagem cirúrgica realizada, os pacientes foram divididos em dois grupos (1 enterolitotomia com colecistectomia no segundo momento; e (2 enterolitotomia, colecistectomia e abordagem da fístula. RESULTADOS: Doze pacientes foram incluídos, sendo 11 mulheres (91,6%, com média de idade de 72,2 anos. Todos os pacientes apresentavam doenças associadas, principalmente hipertensão arterial sistêmica (75%. Dois pacientes não apresentavam sintomas significativos de obstrução intestinal. O diagnóstico de IB foi realizado em seis pacientes (50% antes da laparotomia. O grupo 1 foi constituído de oito pacientes e o grupo 2 de quatro, e a morbidade foi, respectivamente, 33,3% e 8,3%. A mortalidade foi 16,6% (um paciente de cada grupo. CONCLUSÃO: O manejo do IB deve ser individualizado. O tratamento da obstrução mediante remoção do cálculo biliar por enterotomia proximal é a escolha inicial para o tratamento do IB. A colecistectomia e a correção da fístula bilioentérica podem ser realizadas juntamente com a remoção do cálculo, no entanto, em pacientes com comorbidades significativas, esses procedimentos devem ser realizados posteriormente.

  15. Anticuerpos anti-HLA y rechazo agudo del injerto renal en los niños

    OpenAIRE

    Galeas, Rubén Arturo; Gomezchico-Velasco, Rebeca; Valverde, Saúl; Ramón-García, Guillermo; Velásquez-Jones, Luis; Romero-Navarro, Benjamín; Hernández, Ana María; Vargas, Arindal; Leo, Claudia de; Medeiros, Mara

    2010-01-01

    Introducción. A pesar de que las nuevas terapias inmunosupresoras han mejorado notablemente la evolución clínica de los trasplantes renales, los rechazos agudo y crónico siguen limitando la sobrevida a largo plazo del injerto. En base a lo anterior, el objetivo de este estudio fue determinar la presencia de anticuerpos séricos contra antígenos de histocompatibilidad (HLA) clase I y clase II en niños con rechazo agudo del injerto renal. Métodos. Se realizó un estudio clínico prospectivo en pac...

  16. Infarto agudo de miocardio. Guía de práctica clínica

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    Yanier Coll Muñoz

    2011-08-01

    Full Text Available

    La elaboración de esta Guía de Práctica Clínica se justifica, en primer lugar, por la elevada frecuencia de presentación y mortalidad del infarto agudo del miocardio en la población general. Las enfermedades cardiovasculares constituyen en la actualidad la principal causa de muerte en los países industrializados, y se espera que también lo sean en los países en vías de desarrollo en el año 2020.  La presente guía se refiere a los pacientes que presentan síntomas isquémicos o sus equivalentes, y una elevación persistente del segmento ST en el electrocardiograma, o cambios del electrocardiograma de infradesnivel del ST o de la onda T, compatibles con el diagnóstico de IAM sin elevación del ST. Esta Guía no aborda los elementos relacionados directamente con los procedimientos de intervencionismo coronario percutáneo ni la revascularización miocárdica quirúrgica.

  17. Sobrecarga en el cuidador de paciente con infarto agudo al miocardio

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    Norma Lizbeth Ávila Estrada

    2012-12-01

    Full Text Available Introducción: Las enfermedades cardiovasculares constituyen la primera causa de muerte en México, generando un impacto social persistente que involucra tanto a quien lo padece como a quienes lo rodean. Objetivo: Determinar el nivel de sobrecarga en el cuidador con pacientes de infarto agudo miocardio (IAM en el Hospital General de Durango. Materiales y Métodos: Estudio descriptivo no experimental, transversal; 54 familiares de pacientes hospitalizados con diagnóstico de IAM en el Hospital General Durango, no probabilístico por conveniencia. Resultados: La edad promedio en el estudio es de 18 a 25 años correspondiendo al 37%, de los cuales el 66.7% es femenino, 59.3% tiene escolaridad de medios superior, el 72.2% son de procedencia de la ciudad de Durango, con respecto al parentesco del cuidador con la persona que demanda cuidado esta es en su mayoría hijo con un porcentaje de 20.4%; también un alto porcentaje 81.5 % convive con el enfermo y un 63.0% trabaja fuera del hogar, y un 27.8% ha dejado el trabajo parcialmente; el resultado revelo que existe un nivel medio de sobrecarga del 44.2% en el cuidador primario. Discusión y Conclusiones: Son identificables los niveles de sobrecarga en cuidadores de pacientes con IAM generando una serie de variables que alteran la relación cuidador-paciente trayendo consigo una sobrecarga de tipo medio. (Rev Cuid 2012;3(3:342-8.Palabras clave: Cuidados Posteriores, Absentismo Familiar, Atención no Remunerada. (Fuente: DeCS BIREME.

  18. Edad avanzada y factores de riesgo para infarto agudo de miocardio

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    M. A. Ciruzzi

    2002-12-01

    Full Text Available Este estudio caso-control analizó en los sujetos añosos el rol de los factores de riesgo coronario en el desarrollo del infarto agudo de miocardio (IAM, estableció la naturaleza de esta asociación y el grado de riesgo. Los datos fueron obtenidos en una investigación que incluyó 1060 casos y 1071 controles, realizada en 35 unidades coronarias de centros médicos de Argentina entre noviembre de 1991 y agosto de 1994. Nuestro análisis se basó en la información de los sujetos mayores de 65 años. Los casos fueron 427 pacientes con un primer IAM. Los controles fueron 396 sujetos sin evidencias clinicas de enfermedad cardiovascular, seleccionados en los mismos centros que los casos. Los Odds Ratios (OR y su intervalo de confianza del 95% (IC 95% se obtuvieron mediante un análisis de regresión logística, incluyendo variables como la edad, educación, clase social, tabaquismo, antecedente de diabetes o hipertensión arterial, índice de masa corporal e historia familiar de enfermedad coronaria. Los factores de riesgo relacionados independientemente con IAM fueron los siguientes: hipercolesterolemia (colesterol sérico > 240 mg/dl: OR=1.76 (IC 95%: 1.25-2.49, tabaquismo: OR=1.6 (IC 95%: 1.06-2.4, hipertensión arterial: OR=2.05 (IC 95%: 1.51-2.73, diabetes OR=1.71 (IC 95%: 1.12-2.70, historia de un familiar con enfermedad coronaria: OR=1.36 (IC 95%: 0.93-1.97 y de dos o más familiares: OR=2.63 (IC 95%: 1.21-5.71. Este estudio, confirma en los sujetos de edad avanzada la importancia de la hipercolesterolemia, del tabaquismo, la hipertesión arterial, la diabetes y la historia familiar de enfermedad coronaria como factores de riesgo de IAM

  19. Abdome agudo obstrutivo pela veia porta - relato de caso

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    Celeste Gomes Sardinha Oshiro

    2016-10-01

    Full Text Available Introdução: A veia porta pré-duodenal é uma anomalia congênita rara, sintomática em apenas 50% dos casos, sendo que seu diagnóstico é feito por laparotomia exploradora. O tratamento de escolha é cirúrgico, com bom prognóstico. Objetivo: Relatar um caso de Abdome Agudo Obstrutivo por Veia Porta Pré Doudenal (VPPD no período neonatal no Conjunto Hospitalar de Sorocaba. Metodologia: Descrição do referido caso e revisão de literatura. Relato de Caso: Recém-nascido de F.S.S., feminino, de parto normal em 30/05/2016, cuja mãe com 21 anos, apresentou durante pré-natal Diabetes Mellitus Gestacional e polihidrâmnio; negou consanguinidade, vícios e infecções. Ao nascimento, idade gestacional 38 1/7 semanas, peso 2865g, comprimento 47 cm, Apgar 9/9. Durante rotinas de sala de parto, à aspiração gástrica, saída de 55 ml de líquido claro com grumos (LCCG. No 4o dia de vida, episódios de vômito com sangue e distensão abdominal. No 11° dia de vida, realizada Laparotomia Exploradora que identificou dilatação gástrica e duodenal, principalmente na 3° porção, onde passa anteriormente a Veia Porta, comprimindo parcialmente a borda antimesentérica duodenal, o que comprometia seu esvaziamento. Realizada anastomose duodeno-jejunal. Recebeu alimentação parenteral por 15 dias. RN apresentou infecções fúngica e bacteriana, tratadas durante internação. Recebe alta com 46 dias de vida em aleitamento materno e boa recuperação clínica. Conclusão: Existem poucos relatos sobre a formação anômala da veia porta e suas consequências. O diagnóstico pré-natal ou pré-operatório de VPPD raramente é feito. Boa evolução pós correção cirúrgica.

  20. Prevalência de fatores de risco em pacientes com infarto agudo do miocárdio

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    Simone Mathioni Mertins

    2016-01-01

    Full Text Available Objetivo: Identificar a prevalência de fatores de risco em pacientes com infarto agudo do miocárdio, internados em uma Unidade de Terapia Intensiva Coronariana de um hospital da região noroeste do estado do Rio Grande do Sul ̸ Brasil. Metodologia: Estudo quantitativo, descritivo e transversal, realizado no período compreendido entre 25 de abril a 25 de junho de 2012, com 48 pacientes. As variáveis de interesse para este estudo foram as condições sociodemográficas, dados antropométricos, hábitos alimentares e fatores de risco cardiovascular. Resultados: A idade média foi de 59,9 ± 11,55 anos, com predominância do sexo masculino (81,3%, de cor branca (83,3%, casados (70,8%, ensino fundamental incompleto (72,9%, aposentados (37,5%, renda menor que três salários mínimos (58,3% e procedentes da região urbana (72,9%. A prevalência dos fatores de risco se distribuiu da seguinte forma: sedentarismo (91,7%, hipertensão arterial sistêmica (63,8%, estresse (50%, circunferência abdominal alterada (50%, história familiar (43,7%, tabagismo (41,7%, sobrepeso (35,5%, obesidade (33,4%, dislipidemia (23%, diabetes mellitus (20,8% e consumo de álcool (12,5%. Conclusão: Os dados apresentados mostram a elevada prevalência de fatores de risco em pacientes que tiveram infarto agudo do miocárdio e nos direcionam a entender o papel da educação em saúde como estratégia para reduzir as causas de morbimortalidade, além de propor ações de cuidado e autocuidado e mudanças nos hábitos de vida.  Descritores: Fatores de Risco; Infarto do Miocárdio; Educação em Saúde (Fontes: DeCS e BIREME.

  1. Complicaciones mecánicas del infarto agudo de miocardio: aunque infrecuentes, potencialmente letales

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    Jerson Quitian Moreno

    2017-09-01

    Full Text Available Aunque la incidencia de complicaciones mecánicas en el infarto agudo de miocardio ha descendido después de la era de la intervención coronaria percutánea, la mortalidad sigue siendo significativa. La ruptura septal ventricular, la regurgitación mitral aguda y la ruptura de la pared libre del ventrículo izquierdo conforman el espectro de complicaciones mecánicas posteriores al infarto agudo de miocardio. La reparación quirúrgica es el pilar del tratamiento; sin embargo, como puente para la cirugía, el manejo médico permite estabilizar al paciente.

  2. FRACASO RENAL AGUDO EN EL PACIENTE ONCOLOGICO. ANALISIS CLINICO Y PRONOSTICO.

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    Purroy A,

    2004-01-01

    Full Text Available RESUMEN: El fracaso renal agudo es un problema frecuente en el paciente oncológico, que plantea limitaciones en el pronóstico y en el planteamiento terapeútico. El desarrollo de registros de pacientes oncológicos con fracaso renal agudo permite analizar el perfil clínico y plantear aspectos a desarrollar desde el punto de vista terapeútico y sobre todo preventivo. El empleo de determinados índices pronósticos como el ISI (Liaño o el de fallo multiorgánico permite evaluar mejor este perfil clínico. En nuestra experiencia el fracaso renal agudo en el paciente oncológico es una complicación frecuente y relacionada con el proceso de base. Mediante este registro de pacientes hemos identificado un perfil clínico de alto riesgo consistente en un paciente con un fallo renal asociado a un proceso infeccioso, con insuficiencia respiratoria, oligúrico y con una puntuación elevada de esos índices pronósticos.

  3. Síndromes coronarios agudos: epidemiología y diagnóstico

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    Carlos A. Cassiani M.

    2009-01-01

    Full Text Available Los síndromes coronarios agudos son un problema mayor de salud pública en todo el mundo. El síndrome coronario agudo (SCA incluye infarto agudo de miocardio (IAM, con o sin elevación del ST y la angina inestable. La incidencia anual de IAM es 565.000 nuevos eventos y 300.000 ataques recurrentes cada año. Los factores de riesgo para enfermedad cardíaca isquémica (ECI incluyen: tabaquismo, niveles elevados de lípidos séricos, hipertensión arterial, diabetes mellitus, obesidad mórbida, sedentarismo, bajo consumo diario de frutas y vegetales, consumo problemático de alcohol e índice psicosocial. La evaluación inicial de un SCA debe enfocarse en el disconfort toráxico, signos y síntomas asociados y factores de riesgo para SCA. Los marcadores biológicos de lesión miocárdica hoy no son fundamentales para decidir el manejo inicial, aunque han contribuido a una mayor sensibilidad del abordaje diagnóstico y aportan datos para el pronóstico de los pacientes.

  4. Hiperglucemia en el síndrome coronario agudo: informe científico multidisciplinario Hyperglycemia in acute coronary syndrome: multidisciplinary scientific report

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    Patricia Blanco

    2012-04-01

    Full Text Available La hiperglucemia con o sin diabetes preexistente es un hallazgo frecuente en pacientes que cursan un síndrome coronario agudo. Estudios previos han demostrado que la hiperglucemia es altamente prevalente y se asocia a un mayor riesgo de muerte y complicaciones hospitalarias. Los mecanismos fisiopatológicos mediante los cuales la hiperglucemia provoca resultados adversos no son claros, y se desconoce si es un marcador de eventos o su causa. Los efectos perjudiciales de la hiperglucemia en el sistema cardiovascular son múltiples, y el control de los niveles de glucosa con insulina parece mejorar el pronóstico en estos pacientes. Se han desarrollado numerosos protocolos para el control de glucemia que demostraron ser seguros y efectivos. En una iniciativa originada en el Consejo de Emergencias de la Sociedad Argentina de Cardiología, se convocó a expertos de nuestro medio con el propósito de debatir estrategias para el control de la glucemia en pacientes que cursan un síndrome coronario agudo. Este documento refleja lo discutido en este evento académico con la intención de resumir los principales aspectos del control de la glucemia y ofrecer recomendaciones generales de tratamiento en la Unidad Coronaria.Hyperglycemia with or without pre-existing diabetes mellitus, occurs frequently in the setting of acute coronary syndrome. Previous studies have demonstrated that hyperglycemia is highly prevalent and is associated with an increased risk of hospital complications and death. The underlying pathophysiology related an adverse clinical outcome to hyperglycemia is unclear, and it is uncertain whether increased serum glucose is simply a marker of adverse outcomes or their cause. Detrimental effects of hyperglycemia on the cardiovascular system are multiple. Glycemia control with insulin would prevent adverse outcomes. Numerous glucose-control protocols have been developed and tested proving to be safe and effective. In an initiative from the

  5. Aplicación de las escalas de estratificación del riesgo en el diagnóstico de los síndromes coronarios agudos

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    John Jaime Sprockel Díaz

    2017-09-01

    Conclusiones: En una población de pacientes con alta probabilidad para el síndrome coronario agudo, las escalas HEART y TIMI mostraron una mayor capacidad para discriminar el diagnóstico del síndrome coronario agudo.

  6. Frecuencia de infección por VIH en pacientes con episodio agudo de herpes zoster

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    Susana Lazarte Heraud

    2005-01-01

    Full Text Available Objetivo: Evaluar la frecuencia de infección por VIH en pacientes que consultan por episodio agudo de herpes zoster. Material y Métodos: Se incluyeron a todos los pacientes entre 18 y 49 años, atendidos entre setiembre del 2001 y enero del 2003 en el Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas del Hospital Nacional Cayetano Heredia, por un cuadro agudo de herpes zoster, diagnosticado clínicamente. Los criterios de inclusión fueron: status VIH desconocido tanto del paciente como de su pareja; que no presentaran alguna complicación neurológica o presentación atípica de zoster y que no tuvieran signos ni síntomas compatibles con infección por VIH (muguet oral, diarrea crónica, síndrome de desgaste, etc.. Previa firma de consentimiento informado, se tomó muestra de sangre para prueba de ELISA para VIH1. A todos los pacientes con resultado positivo se les realizó western blot. Resultados: Veintiún pacientes cumplieron los criterios del estudio, 14 varones y 7 mujeres. Cinco pacientes (23,8% fueron VIH positivos. De éstos, 4 fueron varones (4/14 y 1 mujer (1/7. No se encontró diferencias significativas en cuanto a la conducta sexual de riesgo. Conclusiones: Se encuentra un porcentaje elevado de infección por VIH en adultos jóvenes que consultan en un hospital general por un cuadro agudo de herpes zoster, sin ningún otro signo ni síntoma de inmunosupresión, independientemente de conductas sexuales de riesgo. Nuestro hallazgo justifica un despistaje de VIH en adultos jóvenes con herpes zoster.

  7. Diagnóstico por imagem do tromboembolismo pulmonar agudo Imaging of acute pulmonary thromboembolism

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    C. Isabela S. Silva

    2004-10-01

    Full Text Available O diagnóstico do tromboembolismo pulmonar agudo é baseado na probabilidade clínica, uso do dímero D (quando disponível e na avaliação por imagem. Os principais métodos de imagem utilizados no diagnóstico são representados por cintilografia ventilação-perfusão, angiografia pulmonar e tomografia computadorizada (TC. Na última década vários estudos têm demonstrado que a TC espiral apresenta elevada sensibilidade e especificidade no diagnóstico de tromboembolismo pulmonar agudo. Uma melhor avaliação das artérias pulmonares tornou-se possível com a recente introdução dos equipamentos de TC espirais com multidetectores. Vários pesquisadores têm sugerido que a angiografia pulmonar por TC espiral deve substituir a cintilografia na avaliação de pacientes com suspeita clinica de tromboembolismo pulmonar agudo. Os autores discutem os principais métodos de imagem utilizados no diagnóstico de tromboembolismo pulmonar agudo enfatizando o papel da TC espiral.The diagnosis of acute pulmonary thromboembolism is based on the clinical probability, use of D-dimer (when available and imaging. The main imaging modalities used in the diagnosis are ventilation-perfusion (V/Q, scintigraphy, angiography, and computed tomography (CT. In the last decade several studies have demonstrated that spiral CT has a high sensitivity and specificity in the diagnosis of acute pulmonary thromboembolism. The evaluation of the pulmonary arteries has further improved with the recent introduction of multidetector spiral CT scanners. Various investigators have suggested that spiral CT pulmonary angiography should replace scintigraphy in the assessment of patients whose symptoms are suggestive of acute PE. This article discusses the role of the various imaging modalities in the diagnosis of acute pulmonary thromboembolism with emphasis on the role of spiral CT.

  8. Agentes trombolíticos en el infarto agudo del miocardio

    OpenAIRE

    Manuel Cué Brugueras

    1995-01-01

    Se presenta un revisión bibliográfica sobre los agentes trombolíticos y su uso en el infarto agudo del miocardio con el objetivo de actualizar a los farmacéuticos y otros profesionales de la salud en la terapéutica de este importante problema de salud a nivel internacional. Se revisaron las bases de datos MEDLINE (1985-9/1994), Excerpta Medica (1985-1993), Internacional Pharmaceutical Abstracts (1970-9/1993) y Predicast (1992-11/1993). En la revisión se abordan los beneficios y riesgos de la ...

  9. El infarto agudo de miocardio, un problema de salud pública

    OpenAIRE

    Caccavo, Alberto

    2010-01-01

    El infarto agudo de miocardio (IAM) es una causa importante de muerte en la Argentina. La mortalidad intrahospitalaria del IAM en la actualidad es de aproximadamente el 10%, al menos en los centros que participan en registros. Su tratamiento está orientado a la reperfusión de la arteria ocluida con angioplastia primaria o trombolíticos. Sin embargo, sólo un pequeño número de hospitales disponen de angioplastia primaria y reciben trombolíticos muchos menos pacientes que los que los requieren. ...

  10. El infarto agudo de miocardio, un problema de salud pública

    OpenAIRE

    Alberto Caccavo

    2010-01-01

    RESUMENEl infarto agudo de miocardio (IAM) es una causa importante de muerte en la Argentina. Lamortalidad intrahospitalaria del IAM en la actualidad es de aproximadamente el 10%, almenos en los centros que participan en registros.Su tratamiento está orientado a la reperfusión de la arteria ocluida con angioplastia primariao trombolíticos. Sin embargo, sólo un pequeño número de hospitales disponen deangioplastia primaria y reciben trombolíticos muchos menos pacientes que los que los requieren...

  11. Abdomen agudo ocasionado por apendicitis aguda de probable origen tuberculoso. Informe de un caso

    OpenAIRE

    Montiel-Jarquín, Álvaro José; Alvarado-Ortega, Iván; Romero-Figueroa, María del Socorro; Rodríguez-Pérez, Fabiola; Rodríguez-Lima, Felipe; Loria-Castellanos, Jorge

    2017-01-01

    RESUMEN Antecedentes: la apendicitis aguda tuberculosa es una enfermedad rara, constituye de 0,001 % a 0,01 % de las formas clínicas de tuberculosis. Se presenta un caso de apendicitis aguda probablemente tuberculosa como causa de abdomen agudo quirúrgico. Caso clínico: hombre de 29 años con cuadro de dolor abdominal leve a moderado que se intensificó y localizó en el hemiabdomen derecho, claudicación, febrícula, vómito, mal estado general, leucocitosis de 11 300/µL y neutrofilia de 91 %....

  12. INFARTO AGUDO DO MIOCÁRDIO: MANUAL DE ORIENTAÇÃO PARA O PACIENTE

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    Fernanda Carneiro Mussi

    Full Text Available Baseado em pesquisa das expectativas de 30 pacientes internados em unidade coronária, os autores apresentam um manual de orientação para o paciente com diagnóstico de Infarto Agudo do Miocárdio. O objetivo do manual é ser um complemento do tratamento dos pacientes com Infarto do Miocárdio, a principal causa de morte em nosso pais. É composto por informações sobre o que é a doença, os fatores de risco a ela associados, retorno as atividades e tratamento.

  13. Validez y confiabilidad de un instrumento de satisfacción del usuario con síndrome febril agudo

    OpenAIRE

    Tiga-Loza, Diana C; Villar-Centeno, Luis á; Güiza-Sanabria, Diana R; Martínez-Vega, Ruth A

    2010-01-01

    Objetivo Determinar la validez y la confiabilidad de un instrumento de satisfacción del paciente con Síndrome Febril Agudo en urgencias y consulta oportuna de la Red Pública de Bucaramanga. Métodos Estudio de evaluación de tecnologías diagnósticas en personas con Síndrome Febril Agudo entre el 2008 y 2009. Se diseñó un cuestionario telefónico a partir de 3 instrumentos en español. Se evaluó validez de contenido mediante sometimiento a expertos y a profesionales de salud y validez facial en un...

  14. Eficacia de la asociación paracetamol-metamizol vs. paracetamol-dexketoprofeno en manejo de dolor agudo postoperatorio

    OpenAIRE

    García Ramiro, M.; Alonso Guardo, L.; Matilla Álvarez, A.; Bartol Sevillano, R.; Vaquero Roncero, L. M.; Muriel Villoria, C.

    2013-01-01

    Objetivo: El uso de fármacos con mecanismos diferentes combinados entre sí para el tratamiento del dolor, en concreto del dolor agudo postoperatorio, forma parte fundamental de un tipo de analgesia llamada multimodal. El objetivo de este trabajo es evaluar la eficacia de la asociación de paracetamol más metamizol y compararla con la asociación de paracetamol más dexketoprofeno en dolor agudo postoperatorio. Métodos: Diseñamos un estudio prospectivo de intervención en el que se incluyeron 42 p...

  15. Millon´s Personality Model and ischemic cardiovascular acute episodes: Profiles of risk in a decision tree

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    María M. Richard's

    2008-01-01

    Full Text Available La identificación de subgrupos de riesgo permite a los psicólogos clínicos desarrollar intervenciones específicas para esos subgrupos. El principal propósito de este trabajo fue encontrar asociaciones estadísticas entre características de personalidad -rasgos y trastornos- y la existencia de episodios isquémicos cardiovasculares agudos según el modelo de personalidad de Theodore Millon. Los análisis del presente estudio se fundamentaron en una muestra de 313 mujeres y hombres entre 31 y 80 años de edad, divididos en dos grupos: un grupo clínico formado por 143 participantes internados a causa de episodios isquémicos cardiovasculares agudos y un grupo control constituido por 170 personas sin antecedentes de enfermedades cardiovasculares. Los resultados mostraron cuatro perfiles de riesgo de personalidad asociados con la existencia de episodios isquémicos agudos y, por tanto, esto posibilita a los psicólogos clínicos el diseño de intervenciones específicas para aquellos subgrupos.

  16. Síndrome coronario agudo y enfermedad de Erdheim-Chester. Patogénesis e implicaciones terapéuticas

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    José Carlos Alarcón-García

    2017-05-01

    Full Text Available La enfermedad de Erdheim-Chester es una histiocitosis celular diferente a la histiocitosis de Langerhans, de origen incierto. Se caracteriza por una implicación multi-orgánica debida a la infiltración de los histiocitos CD68+/CD1a-, en forma de xantogranulomas, que afectan principal y comúnmente a la metáfisis y diáfisis de huesos largos. El diagnóstico se realiza mediante biopsia, donde se revelan histiocitos CD68+/CD1a-, carencia de proteína S, y presencia de gránulos de Birbeck. Se ha subestimado la implicación cardiovascular. Reportamos un caso de un varón de 67 años con la enfermedad de Erdheim-Chester e infarto de miocardio agudo, debido a implicación coronaria, además de enfermedad ósea, vascular, pituitaria y retroperitoneal. Revisamos la literatura relevante y describimos el tratamiento clínico de estos pacientes.

  17. Demoras en la realización de la angioplastia primaria en los pacientes trasladados con infarto agudo de miocardio: un problema médico-asistencial

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    Rodrigo Blanco

    2009-01-01

    Full Text Available IntroducciónEn el infarto agudo de miocardio (IAM está comprobado que cuanto más tempranamente se realice la reperfusión, mejores serán sus resultados a corto y a largo plazos, por lo que el tiempo entre el inicio de los síntomas y la reperfusión coronaria es un elemento de gran importancia en la estrategia de su tratamiento. Este lapso se encuentra conformado por dos períodos: “tiempo paciente” y “tiempo médico-asistencial”. En la angioplastia primaria, el análisis de estos tiempos y sus intervalos es el paso obligado para lograr una reducción de la demora a la reperfusión.ObjetivosAnalizar los tiempos en cada etapa del proceso traslado-realización de una angioplastia, ya sea primaria o de rescate, en pacientes con infarto agudo de miocardio con elevación del segmento ST (IAMEST que debieron ser trasladados desde un hospital derivador a un centro de referencia en el ámbito de la ciudad de Buenos Aires para someterse al procedimiento, como primer paso para un programa de optimización de los tiempos.Material y métodosEstudio prospectivo, observacional, de pacientes derivados al Hospital General de Agudos “Dr. Cosme Argerich” con diagnóstico de IAMEST e indicación de ATC. Se analizaron los tiempos parciales desde el inicio de los síntomas hasta la reperfusión coronaria, para lo cual se consideró “tiempo paciente” desde el inicio de los síntomas hasta la llegada al hospital derivador y “tiempo médico-asistencial” al comprendido entre la llegada al hospital derivador y la insuflación del balón.ResultadosSe incluyeron 313 pacientes, 225 (72% con angioplastia primaria (ATCP y 88 (28% con angioplastia de rescate (ATCR. Las medianas (cuartiles de tiempo en ATCP fueron: tiempo paciente: 90’ (40-240, llegada al hospital derivador-llamada al Equipo de Hemodinamia Cardiovascular de Urgencia (EHCU: 80’ (35-150, llamada EHCU-ingreso hemodinamia: 75’ (55-100, ingreso hemodinamia-balón: 35’ (23-52, tiempo m

  18. Modelos de serviços hospitalares para casos agudos em idosos

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    Coelho Filho João Macedo

    2000-01-01

    Full Text Available Embora a atenção ao idoso seja uma prioridade emergente no Brasil, pouca ênfase tem sido dada a modelos de organização de serviços hospitalares para pacientes geriátricos. São revisados modelos de serviços hospitalares para admissão e manuseio de casos agudos em idosos, com ênfase na discussão sobre o papel e o posicionamento da medicina geriátrica (incluindo sua interface com especialidades e com a clínica médica no âmbito da atenção hospitalar. Foi realizada pesquisa na base de dados Medline (1989-1999, bem como nos principais livros-texto de geriatria e de gerontologia, buscando identificar descrições de serviços hospitalares para cuidado agudo de pacientes idosos. As características dos modelos identificados foram compiladas e descritas à luz de sua adequação à realidade dos serviços de saúde no Brasil. Exemplos de intervenções em geriatria, com efetividade demonstrada através de revisões sistemáticas, foram também citadas. Os modelos mais freqüentemente relatados foram cuidado prolongado, tradicional, baseado na idade cronológica, não especializado e integrado. Adaptações e variantes de alguns desses modelos foram freqüentemente relatadas, assim como seu impacto potencial na efetividade do cuidado geriátrico. Evidências sobre o melhor modelo a seguir não foram identificadas, mas aqueles modelos favorecendo a integração da geriatria com a clínica geral pareceram mais adequados à nossa realidade. Ressalta a necessidade de reestruturação de serviços de saúde para responder às novas demandas que surgem com o envelhecimento da população, bem como do delineamento de serviços hospitalares para casos agudos, importantes para a efetividade do cuidado geriátrico e que devem ser objeto de maior debate e pesquisa no Brasil.

  19. Tratamiento del adulto mayor con síndrome coronario agudo

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    Carolina Pemberthy-López

    2016-11-01

    Full Text Available El adulto mayor se encuentra en una etapa de la vida con cambios fisiológicos importantes que posee repercusiones directas e indirectas sobre su estado clínico, es así como el enfoque diagnóstico y terapéutico de sus patologías debe ser abordado desde una perspectiva diferente, con consideraciones especiales para este grupo poblacional. Lamentablemente, este grupo no ha sido bien representado en los diferentes estudios y por tanto, es mucho lo que desconocemos; su comportamiento y la eficacia de las distintas terapias no están bien establecidos. Teniendo de referencia el síndrome coronario agudo como principal causa de mortalidad en pacientes mayores de 65 años de edad, abordaremos esta entidad desde la evidencia que nos aportan algunos de los registros más importantes al respecto en adultos mayores.

  20. Hepatocarcinoma como causa de abdome agudo em adolescente: relato de caso

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    João Augusto dos Santos Martines

    2012-08-01

    Full Text Available O carcinoma hepatocelular (CHC é pouco prevalente nos países ocidentais, porém é um dos tumores mais freqüentes na Ásia e a quinta causa de câncer no mundo.É relatado um caso de adolescente do sexo feminino sem fatores de risco para um tumor extremamente agressivo, internada no Hospital Universitário da Universidade de São Paulo. A apresentação clínica foi de abdome agudo secundário a sangramento para cavidade peritoneal por ruptura do tumor evidenciado através de tomografia computorizada multidetectores (TCMD confirmado por laparotomia exploradora e biópsia hepática e tratada com rafia hemostática do parênquima hepático.

  1. Variabilidad geográfica de las hospitalizaciones por infarto agudo al miocardio en Costa Rica

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    Melvin Morera Salas

    2014-01-01

    Full Text Available La presente investigación muestra los patrones geográficos de las hospitalizaciones por infarto agudo al miocardio en el seguro público de salud de Costa Rica en el trienio 2010-2012. Para el análisis geográfico por área de salud se utiliza un modelo bayesiano jerárquico espacial. Se estiman razones estandarizadas suavizadas y, como medida de precisión, la probabilidad de que cada área de salud registre un riesgo de hospitalización estadísticamente diferente al promedio nacional. En la determinación de presencia de autocorrelación espacial se utiliza el indicador de la I de Moran. La amplitud entre las variaciones observadas se estima mediante la razón interpercentil (percentil 95/percentil 5 y el coeficiente de variación. La tasa bruta de hospitalizaciones es de 5,8 por 10 mil habitantes en hombres y 2,6 / 10 mil en mujeres. Se registra un rango de variación de más de dos veces en las hospitalizaciones entre las áreas con mayores y menores egresos. Se presenta un patrón de bajas tasas de hospitalizaciones por infarto agudo al miocardio en áreas de salud fuera del Área Metropolitana, donde se encuentran los hospitales nacionales de mayor complejidad. Este elemento podría estar asociado a dificultades en el acceso de los servicios de hospitalización.

  2. Estreptoquinasa recombinante en pacientes con infarto agudo del miocardio. Cardiocentro de Camaguey, 2008

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    Héctor Mariño Cano

    2015-12-01

    Full Text Available Se realizó un estudio descriptivo longitudinal, con el objetivo de valorar la eficacia de la utilización de la Estreptoquinasa Recombinante en pacientes con Infarto Agudo de Miocardio (IMA en el Cardiocentro del Hospital Provincial Docente “Manuel Ascunce Doménech” en la provincia de Camagüey, en el período comprendido de enero a diciembre del 2008. El universo estuvo constituido por 200 pacientes, a los que se les diagnosticó Infarto Agudo de Miocardio y la muestra quedó formada por 80 pacientes que recibieron tratamiento trombolítico, las historias clínicas de los pacientes fueron la principal fuente de obtención de la información, utilizando  las  siguientes  variables: resultados criterio de perfusión, evolución clínica, criterio de reacciones adversas y la influencia que ejerce el tiempo puerta-aguja,  así como los cuidados de enfermería. Al terminar se observó que  el criterio de repercusión de mayor incidencia fue el eléctrico; la mayor cantidad de pacientes tuvieron buena evolución clínica; la hipotensión fue la reacción adversa más frecuente; el tiempo de puerta-aguja  que más incidió  fue el menor, de 3h; a todos los pacientes diagnosticados con infarto, que recibieron tratamiento trombolítico, se les  brindaron  cuidados de enfermería.

  3. Inmunización para influenza y neumococo en prevención cardiovascular

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    María Inés Sosa Liprandi

    2014-06-01

    Full Text Available La relación entre las infecciones respiratorias producidas por el virus de la influenza y el neumococo y los eventos cardiovasculares motivaron la reunión de un grupo interdisciplinario (cardiólogos, clínicos e infectólogos, con el objeto de analizar la evidencia entre la asociación de estos fenómenos y el rol de las estrategias de inmunización en la prevención de la enfermedad cardiovascular. El presente documento sintetiza las conclusiones del grupo de trabajo. El análisis de revisiones sistemáticas sugiere una evidencia consistente entre la infección por influenza y neumococo como desencadenantes de infarto agudo de miocardio y muerte cardiovascular. Los estudios publicados en los últimos 15 años sugieren que la vacunación para influenza y neumococo reducen el riesgo de síndromes coronarios agudos. Con la evidencia existente y teniendo en cuenta los análisis de costo-efectividad, ahorro de costos y perfil de seguridad de las vacunas, las sociedades científicas y agencias gubernamentales de salud, tanto nacionales como internacionales, recomiendan fuertemente la incorporación de la inmunización en el grupo de pacientes con enfermedad cardiovascular crónica.

  4. Utilidad y fiabilidad de las escalas contemporáneas de estimación de riesgo en enfermedades cardiovasculares

    OpenAIRE

    Abu Assi, Emad

    2013-01-01

    Las enfermedades cardiovasculares son la principal causa de morbimortalidad en los países desarrollados. Además, su coste es muy elevado, que, junto con el envejecimiento progresivo de nuestra población, exige estrategias de prevención a fin de contrarrestar sus efectos. En los últimos años, se desarrollaron varias escalas de estratificación de riesgo en el ámbito de las enfermedades cardiovasculares, como el síndrome coronario agudo y las hemorragias derivadas de su manejo; eventos tromboemb...

  5. Identificación de síntomas relacionados al Síndrome de Apnea Obstructiva del sueño en historias clínicas de pacientes con eventos vasculares agudos.

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    Darwin Roger VIZCARRA ESCOBAR

    2006-07-01

    Full Text Available El síndrome de apnea obstructiva del sueño (SAOS se caracteriza por ronquidos, pausas en la respiración y somnolencia diurna excesiva entre los síntomas más relevantes. Se ha demostrado una asociación con incremento de riesgo vascular en pacientes con SAOS. Objetivo: Evaluar si el personal médico busca síntomas relacionados al SAOS en pacientes con un cuadro cerebrovascular o síndrome coronario agudo, en los servicios de Medicina del Hospital Nacional Cayetano Heredia en Lima, Perú, desde septiembre del 2003 hasta septiembre del 2004. Materiales y métodos: Se planteó un estudio observacional retrospectivo. Se revisaron historias clínicas de 291 pacientes con diagnóstico al ingreso de accidente cerebrovascular, ataque isquémico transitorio o síndrome coronario agudo, buscando información sobre síntomas relacionados al SAOS, incluyendo evaluación por especialidades y epicrisis, detallando los evaluadores que recogieron los datos. Resultados: En la evaluación de 291 pacientes participaron 1122 evaluadores, 0,98 % de ellos consignó descartar el SAOS, que correspondió a 9 pacientes. En sólo 1 paciente se sugirió realizar un estudio de polisomnografía para corroborar el diagnóstico, sin ofrecerse ninguna opción terapéutica. Del total de pacientes, en el 6,87 % se indagó por ronquidos durante el sueño, 28,52 % por somnolencia y 0,68 % por episodios de apneas durante el sueño. Conclusiones: No se realiza una adecuada búsqueda del SAOS en pacientes con un evento cardiovascular o cerebrovascular agudo. En los pocos pacientes en los que se sospecha esta patología no existe seguimiento clínico ni tampoco se ofrece opción diagnóstica ni terapéutica alguna. (Rev Med Hered 2006;17:148-155.

  6. Inestabilidad en múltiples placas ateroescleróticas en pacientes fallecidos por infarto agudo de miocardio

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    Ricardo A. Sarmiento

    2011-08-01

    Full Text Available Los procesos inflamatorios en los síndromes coronarios agudos juegan un rol importante en la inestabilidad de la placa ateroesclerótica. Nuestro objetivo fue evaluar la presencia y distribución de placas vulnerables e infiltrados inflamatorios en pacientes fallecidos por infarto agudo de miocardio y su comparación con los hallazgos en pacientes fallecidos por cuadros no coronarios. Se analizaron los estudios anatomopatológicos de corazón de 68 pacientes fallecidos por infarto agudo de miocardio y 15 fallecidos por causa no coronaria. Se registró la presencia de trombo, hemorragia intraplaca, ruptura endotelial e infiltrado inflamatorio. Al evaluar los pacientes fallecidos por IAM, encontramos trombo en 73.5% de las arterias responsables del IAM y en 28.7% de las no responsables (p < 0.0001. La hemorragia intraplaca se halló en el 70.5% de las arterias responsables y en 39.7% de las no responsables, p < 0.0001; ruptura endotelial en el 29.4% de las arterias responsables y en 3.7% de las no responsables, p < 0.0001. No encontramos diferencias en la presencia de infiltrado inflamatorio (76.5% versus 68.4%. Comparando con los fallecidos por causas no coronarias, la presencia de trombo fue significativamente superior (73.5% vs. 13.3%; p < 0.0001, así como la de hemorragia intraplaca (70.5% vs. 0%; p < 0.0001 y de infiltrado inflamatorio en las placas ateroescleroticas (76.5% vs. 46.6%; p = 0.021. En los pacientes fallecidos por infarto agudo de miocardio se observa inestabilidad de placa y actividad inflamatoria, no sólo en la arteria responsable del infarto sino también en las arterias no responsables del infarto.

  7. Actividad inflamatoria en múltiples placas ateroscleróticas en pacientes fallecidos por infarto agudo de miocardio

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    Alejandro García Escudero

    2009-01-01

    Full Text Available IntroducciónEstudios clínicos y anatomopatológicos sugieren que los procesos inflamatorios tienen un papel importante en la inestabilidad de la placa aterosclerótica, dado que en pacientes con síndromes coronarios agudos se observan infiltrados inflamatorios difusos en las arterias coronarias.ObjetivosEvaluar y localizar la distribución de placas vulnerables e infiltrados inflamatorios en pacientes fallecidos por infarto agudo de miocardio.Material y métodosMediante microscopia óptica se estudiaron las arterias coronarias de 58 pacientes fallecidos por infarto de miocardio. En las arterias coronarias relacionadas con el infarto y en las no relacionadas se registraron las siguientes variables: presencia de trombo, rotura de placa, hemorragia intraplaca y presencia de infiltrado inflamatorio.ResultadosAl analizar las diferencias existentes entre las arterias responsables del infarto y en las no responsables se encontraron diferencias significativas con respecto a la presencia de trombo (69% versus 38%; p < 0,008 y de hemorragia intraplaca (69% versus 50%; p < 0,03. No se encontró una diferencia significativa entre la arteria responsable y la no responsable al evaluar la presencia de infiltrado inflamatorio en las placas ateroscleróticas (77% versus 71%; p = ns.ConclusiónEn el infarto agudo de miocardio se comprobó la presencia de actividad inflamatoria que afectaba a más de un vaso, con compromiso de otras arterias además de la responsable del infarto. Se detectó también accidente agudo de placa en más de una arteria coronaria.REV ARGENT CARDIOL 2009;77:81-87.

  8. Hematoma subdural agudo espontâneo e hemorragia intracerebral em paciente com microangiopatia trombótica gestacional

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    Sâmia Yasin Wayhs

    2013-06-01

    Full Text Available Pré-eclâmpsia, síndrome HELLP (hemólise, elevação de enzimas hepáticas e plaquetopenia e fígado gorduroso agudo da gestação são as principais causas de microangiopatia trombótica e disfunção hepática grave durante a gestação, representando um spectrum do mesmo processo patológico. Relatou-se aqui o caso de uma gestante com 35 semanas internada em unidade de terapia intensiva no pós-operatório imediato de cesariana por morte fetal, com náuseas, vômitos e icterícia. Diagnosticaram-se pré-eclâmpsia pós-parto e fígado gorduroso agudo da gestação. Houve evolução tardia com hematoma subdural agudo e hemorragia intracerebral, sendo realizado tratamento neurocirúrgico. A paciente foi a óbito por anemia hemolítica refratária, com sangramento espontâneo em múltiplos órgãos. Pré-eclâmpsia, síndrome HELLP e fígado gorduroso agudo da gestação são processos patológicos que podem se sobrepor e se associar a complicações potencialmente fatais, como a hemorragia intracraniana aqui descrita. Sua detecção e diagnóstico precoces são fundamentais para a instituição de manejo adequado e sucesso do tratamento.

  9. Rotura de la pared libre del ventrículo izquierdo secundaria a infarto agudo de miocardio

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    Claudio Solís

    2009-01-01

    Full Text Available RESUMENAunque la terapia trombolítica y la angioplastia primaria han cambiado radicalmente elmanejo, la evolución y el pronóstico del infarto agudo de miocardio, la rotura de la paredlibre del ventrículo izquierdo todavía implica una tasa elevada de mortalidad.Si bien la mayoría de los pacientes con esta complicación presentan un cuadro agudo ycatastrófico, que se caracteriza por taponamiento cardíaco, disociación electromecánica ymuerte en pocos minutos, aproximadamente un tercio de ellos tienen una evolución subagudacon hipotensión sostenida y diversos grados de derrame pericárdico, lo que posibilita laimplementación de medidas terapéuticas necesarias como puente al tratamiento quirúrgicoresolutivo.En este trabajo se presenta una revisión actualizada de las características clínicas yecocardiográficas de los pacientes con rotura de la pared libre del ventrículo izquierdo asociadacon infarto agudo de miocardio, con el objetivo de destacar los puntos clave del diagnóstico e incrementar la sospecha clínica de una entidad grave, no siempre fatal.REV ARGENT CARDIOL 2009;77:395-404.

  10. Comportamiento del Intervalo QT corregido prolongado en el síndrome coronario agudo, sin elevación del segmento ST

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    Amauris Modesto Valera Sales

    2015-12-01

    Full Text Available Se realizó un estudio descriptivo transversal prospectivo, para determinar el comportamiento del intervalo QT corregido prolongado, en pacientes con síndrome coronario agudo sin elevación del segmento ST, en el Centro Diagnóstico Integral “Los Arales”, San Diego, año 2009. El universo fue de 48 pacientes y la muestra incluyó a 29 pacientes con ECG normal o sin nuevos cambios isquémicos. Al ingreso se determinaron los valores del intervalo QT corregido, las variables demográficas, antecedentes personales, niveles enzimáticos de CK-MB y el score TIMI. Estos resultados se correlacionaron con la aparición de eventos clínicos (muerte, infarto no fatal y revascularización un mes después del ingreso. De los 29 pacientes analizados sólo 11 (38% presentaron eventos clínicos, mientras que los restantes 18 (62% no los tuvieron. Los pacientes con eventos presentaron valores del iQTc más prolongados por encima del punto de corte. En ambos grupos predominó el sexo masculino y el grupo de edad más frecuente fue el de 60 a 69 años. El tabaquismo, la hipertensión y la hipercolesterolemia fueron los más prevalentes para ambos grupos, así como el uso previo de aspirina. La estratificación de riesgo TIMI y los parámetros basales en los pacientes estudiados fueron mayores y revelan un mayor porcentaje en el grupo con eventos clínicos. Los resultados demuestran que el iQTc predice eventos adversos cardiovasculares hasta 30 días después del ingreso.

  11. Infarto agudo del miocardio sin elevación del segmento T: Consideraciones fisiopatológicas y clínicas Heart attack without an elevation of the T segment: Clinical and pathophysiological

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    Maikel Rodulfo García

    2010-09-01

    Full Text Available Se revisaron numerosos documentos (impresos y electrónicos sobre afecciones cardiovasculares, particularmente acerca del infarto agudo del miocardio sin elevación del segmento T, teniendo en cuenta que la mortalidad hospitalaria es menor cuando se produce un síndrome coronario con esa característica. Para actualizar el tema se valoraron diversos aspectos relacionados con concepto, clasificación, fisiopatología, diagnóstico, cuadro clínico, exámenes complementarios y factores de riesgo, puesto que las enfermedades del corazón son actualmente la principal causa de muerte en naciones industrializadas y se espera que también lo sean en los países en vías de desarrollo para el 2020, entre ellos Cuba.Several documents (printed and electronic about cardiovascular diseases were reviewed, particularly heart attack without an elevation of the T-segment, taking into account that the hospital mortality is lower when a coronary syndrome with that characteristic occurs. To update the topic several aspects related to concept, classification, pathophysiology, diagnosis, clinical pattern, laboratory tests and risk factors were valued since heart diseases are actually the main cause of death in industrialized nations and it is expected that they will also be the same cause of death in developing countries for 2020, among them, Cuba.

  12. Infarto agudo do miocárdio na 31ª semana de gravidez: relato de caso

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    Filipa Pires Duarte

    2011-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A ocorrência de infarto agudo do miocárdio (IAM durante a gravidez é rara. Os autores descrevem o caso de IAM numa grávida de 31 semanas e a importância da existência de uma equipe multidisciplinar para sua abordagem. RELATO DO CASO: Grávida de 31 semanas, com antecedentes de tabagismo, alcoolismo e hipertensão, internada após um episódio de síncope. Na admissão, encontrava-se consciente e assintomática, embora hipotensa. O eletrocardiograma evidenciou marcada elevação do segmento ST em DI, AVL, V1-V6. Pesquisa de enzimas cardíacas foi positiva. O ecocardiograma transtorácico demonstrou redução da contratilidade ventricular esquerda e septal e uma fração de ejeção de 30%. A angiografia revelou oclusão proximal da artéria descendente anterior. Por insucesso da angioplastia por balão, foi colocado um stent metálico. A paciente iniciou terapêutica com b-bloqueadores, aspirina e clopidogrel. Em relação ao parto, optou-se por realizar cesariana eletiva, quatro semanas após o IAM. Suspendeu-se o clopidogrel sete dias antes do parto. A função cardíaca pré-operatória foi otimizada com infusão de levosimendana iniciada no dia anterior. A cesariana decorreu sob bloqueio peridural. O período intraoperatório decorreu sem complicações, à exceção de moderada hipotensão facilmente corrigida com fenilefrina. O índice de Apgar do recém-nascido foi de 9/10. CONCLUSÕES: Este é um dos poucos casos de infarto agudo do miocárdio e angioplastia descritos durante a gravidez. Os autores discutem as decisões tomadas pela equipe multidisciplinar, constituída por anestesiologistas, obstetras, cardiologistas e neonatologistas, notadamente no que se refere à dupla antiagregação plaquetária, ao tipo de parto e à anestesia.

  13. Manejo do paciente com infarto agudo do miocárdio atendido no SUS

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    Emerson de Albuquerque Seixas

    2016-10-01

    Full Text Available Introdução: O Infarto Agudo do Miocárdio (IAM é causado pela interrupção do fluxo sanguíneo nas artérias coronárias que irrigam o miocárdio. Trata-se de um evento com alta prevalência, que necessita de internação hospitalar e rápido tratamento. Objetivos: Descrever um caso de IAM que recebeu terapia trombolítica incompleta e realizou angioplastia parcial; Metodologia: Relato de caso de paciente internado no Conjunto Hospitalar de Sorocaba; Relato de Caso: SSA, 74anos, masculino, hipertenso e diabético há 20 anos, procurou o Pronto-Socorro na origem no dia 01/09/2015 com quadro de dor precordial intensa, após realização de esforço físico. Ao exame físico, apresentava-se taquicárdico (FC:150bpm e hipertenso (PA:230X120mmHg.Foi realizado ECG, que evidenciou supradesnivelamento do segmento ST em parede anterior extensa (de V1 a V5,DI e aVL. Foi optado pelo tratamento com agente trombolítico, porém o local só dispunha de metade da dose recomendada. Então foi transferido para o Conjunto Hospitalar de Sorocaba, onde foi optado por não realizar o restante da medicação. Cateterismo cardíaco realizado somente 14 dias depois, evidenciando 4 lesões. Realizada uma angioplastia com implante de apenas 2 stents. Foi solicitado nova angioplastia, que foi negada. Recebeu alta e atualmente aguarda a liberação do procedimento via ambulatorial, com quadro de angina estável. Conclusões: O relato reforça a necessidade da melhoria das condições de atendimento e tratamento de pacientes vítimas de infarto agudo do miocárdio no SUS.

  14. Sindrome confusional agudo por abstinencia aguda de nicotina Delirium due to acute nicotine withdrawal

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    Manuel Klein

    2002-08-01

    Full Text Available El síndrome confusional agudo (SCA o delirium en pacientes hospitalizados es un problema frecuente y grave. Se caracteriza por síntomas de comienzo agudo y curso fluctuante con inatención, pensamiento desorganizado, y con distintos niveles de alteración de la conciencia.En la bibliografía consultada, el SCA como manifestación de un síndrome de abstinencia aguda nicotínica fue descripto en solo ocho casos. Presentamos el caso de un tabaquista grave que, internado por una reagudización de su enfermedad pulmonar obstructiva crónica (EPOC, presentó un cuadro de SCA al tercer día de abstinencia tabacal, cediendo los síntomas tras la administración de un parche de nicotina. Lo descripto sugiere que en pacientes internados que presentan SCA y agitación, con fuertes antecedentes de tabaquismo, un simple ensayo con un parche de nicotina puede ofrecer en pocas horas una notable respuesta terapéutica y a su vez un test confirmatorio. El reconocimiento del SCA como forma de presentación de la abstinencia nicotínica permitirá identificar casos habitualmente complejos en los que se podrá implementar una sencilla y eficaz alternativa terapéutica.Delirium or acute confusional state among hospitalized patients is a frequent and serious problem. It is characterized by acute onset symptoms, fluctuating course, impaired attention, unorganized thinking, and altered level of conciousness. Delirium, as a manifestation of acute nicotine withdrawal syndrome has been reported in the reviewed literature only in eight cases. We report the case of a heavy smoker admitted because of a reagudization of his chronic obstructive pulmonary disease. At the third day of nicotine abstinence, he developed delirium with a rapid improvement of his symptoms after treatment with a transdermal nicotine patch. This description suggests that in hospitalized heavy smokers who develop delirium with agitation, a simple trial with a nicotine patch can offer a dramatic

  15. Efectos cardiovasculares debido al consumo de cannabinoides

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    Oscar J. León

    2018-05-01

    Full Text Available Resumen: Objetivo: dar a conocer los efectos cardiovasculares secundarios al consumo de marihuana según lo reportado en la literatura médica. Métodos: se realizó una búsqueda con los términos MESH “Cannabis”, “Marijuana smoking” y “adverse effects” en la base de datos PubMed hasta el año 2016. Se obtuvieron 265 referencias. Se excluyeron cartas de editores, protocolos de investigación en proceso, población pediátrica (menores de 18 años, embarazadas, referencias en idiomas diferentes a inglés y español y se escogieron solo referencias relacionadas con efectos cardiovasculares. Resultados: se han establecido dos tipos de receptores de cannabinoides, los CB1 y los CB2, con localizaciones a nivel del sistema nervioso central, endotelial, renal y músculo liso. En la actualidad el consumo de marihuana ha venido en aumento y los médicos poco conocen de sus efectos y los diferentes nombres comerciales para esta sustancia. Existen efectos protectores a nivel vascular con detención de la progresión de la placa aterosclerótica y a la vez múltiples efectos no deseados como taquicardia, hipotensión y bradicardia. Múltiples reportes de caso documentan la relación de la marihuana con el infarto agudo de miocardio con o sin lesión de las arterias coronarias, así como con hemorragia subaracnoidea, pero no existen mecanismos claramente descritos que expliquen una relación directa con estos desenlaces. Conclusiones: se conoce la fisiopatología y los receptores donde actúan los cannabinoides generando efectos tanto protectores como dañinos. Existe fuerte correlación con enfermedad cardiovascular, principalmente síndrome coronario agudo, pero el mecanismo fisiopatológico aún no es claro. Abstract: Objective: To determine the cardiovascular side-effects of smoking marihuana according to that reported in the medical literature. Methods: A search was performed using the MeSH terms, “Cannabis”, “Marijuana smoking” and

  16. Cardiovascular radiology

    International Nuclear Information System (INIS)

    VanAman, M.; Mueller, C.F.

    1985-01-01

    Soon after Roentgen documented the uses of x-rays in 1895, fluoroscopic and film evaluation of the heart began. Even today the chest roentgenogram remains one of the first and most frequently used studies for the evaluation of the normal and abnormal heart and great vessels. This chapter gives an overview of plain film evaluation of the cardiovascular system and follow up with comments on the newer imaging modalities of computed tomography, and digital subtraction angiography, in the cardiovascular disease workup. The authors present an evaluation of plain films of the chest, which remains their most cost effective, available, simple, and reliable initial screening tool in the evaluation of cardiovascular disease

  17. Edad avanzada y factores de riesgo para infarto agudo de miocardio Risk factors for acute myocardial infarction in the elderly

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    M. A. Ciruzzi

    2002-12-01

    Full Text Available Este estudio caso-control analizó en los sujetos añosos el rol de los factores de riesgo coronario en el desarrollo del infarto agudo de miocardio (IAM, estableció la naturaleza de esta asociación y el grado de riesgo. Los datos fueron obtenidos en una investigación que incluyó 1060 casos y 1071 controles, realizada en 35 unidades coronarias de centros médicos de Argentina entre noviembre de 1991 y agosto de 1994. Nuestro análisis se basó en la información de los sujetos mayores de 65 años. Los casos fueron 427 pacientes con un primer IAM. Los controles fueron 396 sujetos sin evidencias clinicas de enfermedad cardiovascular, seleccionados en los mismos centros que los casos. Los Odds Ratios (OR y su intervalo de confianza del 95% (IC 95% se obtuvieron mediante un análisis de regresión logística, incluyendo variables como la edad, educación, clase social, tabaquismo, antecedente de diabetes o hipertensión arterial, índice de masa corporal e historia familiar de enfermedad coronaria. Los factores de riesgo relacionados independientemente con IAM fueron los siguientes: hipercolesterolemia (colesterol sérico > 240 mg/dl: OR=1.76 (IC 95%: 1.25-2.49, tabaquismo: OR=1.6 (IC 95%: 1.06-2.4, hipertensión arterial: OR=2.05 (IC 95%: 1.51-2.73, diabetes OR=1.71 (IC 95%: 1.12-2.70, historia de un familiar con enfermedad coronaria: OR=1.36 (IC 95%: 0.93-1.97 y de dos o más familiares: OR=2.63 (IC 95%: 1.21-5.71. Este estudio, confirma en los sujetos de edad avanzada la importancia de la hipercolesterolemia, del tabaquismo, la hipertesión arterial, la diabetes y la historia familiar de enfermedad coronaria como factores de riesgo de IAMThis case-control study, analized the role of coronary risk factors in acute myocardial infarction (AMI in the elderly, and established the nature of this association and the degree of risk. Data were derived from an investigation (1060 cases and 1071 controls conducted in 35 coronary care units from clinical

  18. Current perspectives of acute pain treatment Perspectivas actuales de tratamiento del paciente con dolor agudo

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    Tiberio Alvarez Echeverri

    1993-03-01

    Full Text Available

    In the last years opioids have become of great importance in the relief of postoperative and other forms of acute pain. Reasons for this trend have been the availability of agonist opioids like phentanyl. sulphentanyl and alphentanyl and the results of research on the physlology. The pharmacology and the chemistry of drug receptors and neurotransmitters. The studies on chemicals other than opioids that contribute to pain relief when administered through different ways. specially the spinal. Have also influenced such a trend.

    En los últimos años los opiáceos han adquirido gran importancia en el alivio del dolor agudo especialmente del tipo postoperatorio. Una de las razones ha sido la disponibilidad de morfínicos agonistas como el fentanil, el sufentanil y el alfentanil; otra es la investigación de la fisiología, la farmacología y la química de los receptores y los neurotransmisores como de sustancias diferentes a los opláceos, aplicadas por diferentes vías en especial la espinal, que coadyuvan al alivio del dolor.

  19. ANESTESIA PARA AMPUTACIÓN SUPRACONDÍLEA EN PACIENTE CON SÍNDROME CORONARIO AGUDO / Anesthesia for supracondylar amputation in patient with acute coronary syndrome

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    Marilyn Ramírez Méndez

    2012-03-01

    Full Text Available Resumen La insuficiencia arterial periférica es una enfermedad que se asocia a factores de riesgo aterogénico reconocidos, y es más frecuente en personas con hiperlipidemia, diabetes mellitus y hábito de fumar. Se presenta el caso de una mujer de 67 años de edad, con antecedentes de hipertensión arterial, diabetes mellitus e infarto de miocardio antiguo, que ingresa por signos de inflamación aguda del miembro inferior derecho como consecuencia de una insuficiencia arterial periférica. A los 8 días del ingreso presentó un síndrome coronario agudo sin elevación del segmento ST, con fallo de bomba Killip II, y una vez compensada fue anunciada para amputación supracondílea de urgencia, debido a una gangrena isquémica. Se decidió utilizar anestesia espinal subaracnoidea selectiva del miembro inferior derecho, a cual se aplicó sin complicaciones y favoreció el adecuado desarrollo de la cirugía planificada. A las 72 horas la paciente fue egresada de la UCI, sin síntomas cardiovasculares y compensación metabólica. / Abstract Peripheral arterial insufficiency is a disease that is associated with known atherogenic risk factors, and is more common in people with hyperlipidemia, diabetes mellitus and smoking habit. A case of a 67-year-old woman with a history of hypertension, diabetes mellitus and old myocardial infarction is presented. She was admitted for signs of acute inflammation of the right leg due to peripheral arterial insufficiency. 8 days after admission she presented an acute coronary syndrome without ST segment elevation with pump failure (Killip class II, and once compensated she was scheduled for emergency supracondylar amputation due to ischemic gangrene. It was decided to use selective spinal subarachnoid from the right leg, which was applied without complications and favored the proper development of the planned surgery. At 72 hours, the patient was discharged from the ICU, with metabolic compensation and without

  20. Frecuencia de secuela renal pos evento agudo en síndrome urémico hemolítico

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    Jose Antonio Lulli-Cantoni

    2015-04-01

    Full Text Available Objetivos: Determinar la frecuencia de secuela renal después del evento agudo de Síndrome Urémico Hemolítico (SUH en niños y los factores asociados a la presencia de secuelas. Material y métodos: Estudio descriptivo y retrospectivo. Se revisaron las historias clínicas de los pacientes con SUH en el HNCH de 1997 al 2012, y se registraron datos de características clínicas, hallazgos de laboratorio y parámetros de función renal al ingreso, al alta y a los seis meses después del alta. En los casos que no contaban con control a los 6 meses, se intentó contactar a los pacientes para tomar nuevos controles. Resultados: Siete de 12 pacientes presentaron disminución en la tasa de filtración glomerular (TFG o proteinuria o hipertensión a los 6 meses o más después del episodio agudo, con un promedio de 30,75 meses de seguimiento. Tanto en los pacientes con secuelas como con recuperación renal se encontró una distribución similar de los factores asociados a secuelas como hipertensión al alta, proteinuria al alta, necesidad de diálisis, oligoanuria, leucocitosis > 20 000 cel/mm3 y síntomas neurológicos. Sin embargo algunas variables como oligoanuria y necesidad de diálisis se encontraron a niveles por debajo de los descritos en la literatura. Conclusiones: Es claro que existen pacientes con secuelas renales luego del episodio agudo de SUH que además presentan varios factores predictores de secuelas descritos en la literatura.

  1. Grupos de utilizacion de recursos en unidades de agudos y media estancia de servicios de geriatria

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    Solano Jaurrieta Juan José

    2001-01-01

    Full Text Available Fundamentos: En los últimos años se han implantado en nuestro país Sistemas de Clasificación de Pacientes (SCP con objeto de medir el «producto hospitalario». Sin embargo los sistemas más tradicionales resultan poco adecuados para la población anciana, en los que la incapacidad asociada a la enfermedad resulta determinante para explicar el consumo de recursos y los resultados asistenciales. Por ello, nos planteamos aplicar en servicios especializados de atención al anciano un sistema que contempla este parámetro, los Grupos de Utilización de Recursos (RUG, analizando las características y diferencias en la distribución en función de RUG en cuatro Servicios de Geriatría. Métodos: Se estudian transversalmente, mediante cortes sucesivos en períodos superiores a la estancia media en cada unidad, los pacientes ingresados en las unidades de agudos y media estancia de los Servicios de Geriatría del Hospital Monte Naranco (HMN (n=318, Hospital Central de la Cruz Roja (HCCR (n=384, Hospital General de Guadalajara (HG (n=272 y Hospital Virgen del Valle (HVV (n=390, en lo relativo a su distribución según la clasificación RUG-T18. Las posibles diferencias entre los centros se analizaron mediante el test estadístico chi-cuadrado (SPSS para windows Resultados: Para el conjunto de la muestra los pacientes se concentran en los grupos R, S y C de la clasificación, con muy escasa representación de los grupos P y B, detectándose diferencias entre los centros. Así, el HCCR es el que maneja una mayor proporción de pacientes del grupo R (47,64% vs. 23,66% en el HMN, 20,57% en el HG y 20,53% en el HVV y una menor proporción de pacientes del grupo S (3,12% vs 6,40% en el HMN, 9,92% en el HG y 9,76% en el HVV y C (48,94% vs 76,29% en el HMN, 66,89% en el HG y 68,36% en el HVV. Igualmente es posible detectar diferencias en el análisis individual para las unidades de agudos y media estancia. Conclusiones: Los grupos de utilización de recursos

  2. GRUPOS DE UTILIZACION DE RECURSOS EN UNIDADES DE AGUDOS Y MEDIA ESTANCIA DE SERVICIOS DE GERIATRIA

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    Juan José Solano Jaurrieta

    2001-01-01

    Full Text Available Fundamentos: En los últimos años se han implantado en nuestro país Sistemas de Clasificación de Pacientes (SCP con objeto de medir el «producto hospitalario». Sin embargo los sistemas más tradicionales resultan poco adecuados para la población anciana, en los que la incapacidad asociada a la enfermedad resulta determinante para explicar el consumo de recursos y los resultados asistenciales. Por ello, nos planteamos aplicar en servicios especializados de atención al anciano un sistema que contempla este parámetro, los Grupos de Utilización de Recursos (RUG, analizando las características y diferencias en la distribución en función de RUG en cuatro Servicios de Geriatría. Métodos: Se estudian transversalmente, mediante cortes sucesivos en períodos superiores a la estancia media en cada unidad, los pacientes ingresados en las unidades de agudos y media estancia de los Servicios de Geriatría del Hospital Monte Naranco (HMN (n=318, Hospital Central de la Cruz Roja (HCCR (n=384, Hospital General de Guadalajara (HG (n=272 y Hospital Virgen del Valle (HVV (n=390, en lo relativo a su distribución según la clasificación RUG-T18. Las posibles diferencias entre los centros se analizaron mediante el test estadístico chi-cuadrado (SPSS para windows Resultados: Para el conjunto de la muestra los pacientes se concentran en los grupos R, S y C de la clasificación, con muy escasa representación de los grupos P y B, detectándose diferencias entre los centros. Así, el HCCR es el que maneja una mayor proporción de pacientes del grupo R (47,64% vs. 23,66% en el HMN, 20,57% en el HG y 20,53% en el HVV y una menor proporción de pacientes del grupo S (3,12% vs 6,40% en el HMN, 9,92% en el HG y 9,76% en el HVV y C (48,94% vs 76,29% en el HMN, 66,89% en el HG y 68,36% en el HVV. Igualmente es posible detectar diferencias en el análisis individual para las unidades de agudos y media estancia. Conclusiones: Los grupos de utilización de recursos

  3. Morbilidad y mortalidad en pacientes con infarto agudo de miocardio ST elevado en un hospital general

    Directory of Open Access Journals (Sweden)

    Eduardo Carcausto

    2010-10-01

    Full Text Available Objetivo: Determinar la morbilidad y mortalidad de los pacientes con infarto agudo de miocardio ST elevado (IMA STE atendidos en un hospital general y describir sus características demográficas, clínicas y epidemiológicas. Material y métodos: Estudio descriptivo, serie de casos, retrospectivo, en pacientes con IMA STE en el Hospital Nacional Cayetano Heredia, del 1 de enero a 31 de diciembre del 2007. Se registraron variables clínicas y de laboratorio. Resultados: Se incluyeron 30 casos. El 86,7% fueron varones. La edad media fue de 62,8±12,6 años. El antecedente de hipertensión arterial se encontró en 57%, obesidad en 40%, tabaquismo en 40%, y de diabetes mellitus en 30%. El dolor torácico típico ocurrió en 75% de pacientes. El 50% de pacientes tuvieron hipertensión no controlada a la admisión, 33% leucocitosis, y 46% glicemia >110 mg/dl. Sólo 25% recibió terapia de reperfusión, 33,3% de casos de forma exitosa, siendo el tiempo puerta-aguja de 250 ± 114 minutos. Las complicaciones ocurrieron en 26,6% de pacientes, siendo la mortalidad de 13,3%. El 76% ingresó al hospital con un tiempo de dolor menor de 3 horas, Conclusiones: Los pacientes con IMA ST elevado fueron predominantemente varones, mayores de 60 años, ingresaron al hospital con un tiempo de dolor torácico menor de tres horas y un mínimo porcentaje recibió terapia de repercusión. Las arritmias fueron las complicaciones más frecuentes y la mortalidad post IMA alcanzó 13,3 % de los casos.(Rev Med Hered 2010;21:202-207.

  4. Adherencia al tratamiento y calidad de vida en personas con infarto agudo de miocardio

    Directory of Open Access Journals (Sweden)

    Jennifer Rojas-Reyes

    2016-01-01

    Full Text Available Objetivo: identificar la asociación entre adherencia al tratamiento y calidad de vida relacionada con la salud (CVRS en población con infarto agudo de miocardio (IAM. Materiales y método: estudio cuantitativo de diseño descriptivo correlacional de corte transversal. Se eligieron 180 participantes por muestreo de tipo probabilístico con selección aleatoria simple. Para el análisis estadístico, se utilizó estadística no paramétrica con correlación de Spearman. Resultados: la edad media fue de 63 años, el promedio de tiempo transcurrido después del infarto fue de 35 meses. Frente al nivel de adherencia al tratamiento, predominó la adherencia total (54 %, adherencia parcial (45%; en cuanto a la calidad de vida relacionada con la salud, el 27 % tuvo un bajo nivel; respecto a la correlación de Spearman, se estableció un coeficiente de -0,315 con una significancia de p=0,00, donde el número negativo es reflejo de la naturaleza de las escalas con las que fueron medidas las variables, por lo que la correlación es positiva, significativa, pero numéricamente modesta. Conclusión: la asociación entre adherencia al tratamiento y calidad de vida relacionada con la salud evidencia en una correlación estadísticamente significativa, pero catalogada como modesta, siendo estos resultados coherentes con la multidimensionalidad de los fenómenos.

  5. Terapia trombolítica en pacientes con infarto agudo de miocardio en Cienfuegos

    Directory of Open Access Journals (Sweden)

    Lázaro Abilio Hernández Rodríguez

    2014-03-01

    Full Text Available Fundamento: el tratamiento trombolítico practicado a menos de dos horas, tras el inicio del infarto tiene resultados similares a la reperfusión mecánica. Objetivo: describir aspectos relevantes de la terapia trombolítica en pacientes con infarto agudo de miocardio con elevación del segmento ST en Cienfuegos. Métodos: estudio descriptivo, prospectivo, en 225 pacientes egresados (vivos y fallecidos desde el 1o de abril de 2012 al 31 marzo de 2013, de la Unidad de Cuidados Integrales del Corazón y la Unidad de Cuidados Intensivos Polivalentes, del Hospital Dr. Gustavo Aldereguía Lima. Las variables estudiadas se obtuvieron de la revisión de las historias clínicas e incluyeron: variables demográficas y clínicas, tiempos de demora, sitio, motivo de exclusión y nivel de prioridad para la trombolisis. Resultados: la media de edad superó los 60 años. Predominaron los hombres, hipertensos y de alto riesgo según la escala GRACE. El 29,7 % de los pacientes no recibió terapia trombolítica, debido mayormente al factor tiempo y la mayoría (82,3 % se trató en el Hospital. Las medianas de los tiempos de demora: síntomas-puerta, puerta-droga y síntomas-droga fueron 90, 35 y 140 minutos respectivamente. Conclusiones: la trombolisis extrahospitalaria acorta el tiempo total de isquemia, pero pocos pacientes se beneficiaron de ella. Los retrasos para la terapia trombolítica en Cienfuegos continúan por encima de los estándares requeridos.

  6. Radicales libres de oxígeno y distress respiratorio agudo

    Directory of Open Access Journals (Sweden)

    Aracelis E. Dorado Lambert

    2000-09-01

    Full Text Available Se realizó una revisión acerca de la formación de radicales libres de oxígeno en el organismo, así como el aumento exagerado de su génesis durante la exposición a altas concentraciones de oxígeno y en el desarrollo de la explosión respiratoria que acompaña la fagocitosis. Se analiza además la formación de estos radicales en el pulmón durante la evolución del distress respiratorio agudo. Se abordó, posteriormente, el uso actual, sobre todo en el ámbito internacional, de los antioxidantes y bloqueadores de la lipoperoxidación para disminuir los efectos adversos de los radicales libres. A pesar de estas nuevas medidas, se corrobora que la disminución experimentada en la mortalidad por esta entidad, obedece a la optimización de los cuidados respiratorios, en especial la ventilación mecánica.The formation of free oxygen radicals in the body and the excessive increase of its genesis during exposure to high concentrations of oxygen and in the development of respiratory burst accompanying phagocytosis were reviewed. Also the formation of these radicals in lung during acute respiratory distress was analyzed. Similarly, the present use at the international level of antioxidants and lipoperoxidation blockers to diminish adverse effects of free radicals are addressed in this paper. In spite of these new measures, it was confirmed that the reduction of mortality rate from this disease was due to the improvement of respiratory care particularly the mechanical ventilation.

  7. Daño pulmonar agudo asociada a transfusión en el embarazo

    Directory of Open Access Journals (Sweden)

    Silvia María Melians Abreu

    2014-06-01

    Full Text Available Introducción: el daño pulmonar agudo asociado a la transfusión es una reacción adversa a la transfusión poco frecuente, la mortalidad se ha estimado entre 1-10 %. Su diagnóstico es clínico e infrecuentemente sospechado, su incidencia es baja. Presentación del caso: se presentaron dos transfusión-related-acute-lunginjury en dos gestantes con 28,5 y 32 semanas de embarazo respectivamente, hospitalizadas en la salas de cuidados materno perinatales con enfermedades asociadas al embarazo, a quienes se le administraron componentes sanguíneos, ambas a las 5 horas de transfundidas; presentaron el síndrome clínico con hipoxemia moderada y necesitaron ventilación; con estos hallazgos y la relación temporal con la transfusión. Se realizó el diagnóstico de síndrome de dificultad respiratoria aguda moderada asociada a transfusión. Conclusiones: el resultado fue óptimo con resolución completa del evento respiratorio. Se considera importante reportar ambos casos dado su aparición en embarazadas, causa poco frecuente informada en la literatura y la importancia de conservar la salud de la madre del niño y la niña e incentivar la notificación de esta reacción adversa a la transfusión al banco de sangre para fortalecer el sistema de hemovigilancia.

  8. Nefropatía por contraste en el síndrome coronario agudo

    Directory of Open Access Journals (Sweden)

    Mariana Carnevalini

    2011-10-01

    Full Text Available La nefropatía inducida por contraste (NIC es una de las causas más frecuentes de insuficiencia renal en pacientes internados. En el síndrome coronario agudo (SCA, la presencia de NIC aumenta la morbimortalidad. Las medidas de profilaxis y los factores de riesgo intervinientes de NIC en SCA no han sido determinados con exactitud. El objetivo de este estudio fue evaluar la incidencia de NIC y los factores asociados a su desarrollo en pacientes ingresados en unidad coronaria con requerimiento de cinecoronariografía (CCG. Se realizó un estudio de cohorte retrospectivo. Se incluyeron pacientes consecutivos cursando SCA estudiados con CCG dentro de las 72 horas de su admisión. Se definió NIC al aumento del 25% del valor de creatinina a las 48 h sobre el nivel basal de ingreso. El período de inclusión fue entre el 1° de enero de 2004 hasta el 30 de junio de 2010. Se analizaron 125 casos. La incidencia de NIC fue del 10.4% (n = 13. En el análisis multivariado, los factores asociados independientemente a su desarrollo fueron la edad [OR 1.05 (IC 95% 1.004 - 1.11 p = 0.034], la angioplastia a múltiple vaso [OR 2.2 (IC 95% 1.07 - 4.8, p = 0.03] y el volumen de contraste utilizado [OR 1.007 (IC 95% 1.001 - 1.01, p = 0.014].

  9. Descripción de un brote de enfisema y edema pulmonar agudo del bovino (EPAB) en Parral (Chile)

    OpenAIRE

    URRUTIA, H.; BREVIS, C.; QUEZADA, M.; DONOSO, S.

    1997-01-01

    Se describe un brote de enfisema y edema alveolar agudo del bovino (EPAB) ocurrido en la zona centro-sur a fines del verano de 1995. Los animales Frisón negro, de aproximadamente 2 años de edad, fueron afectados después de cambiarse de una pradera fibrosa a una suculenta de alfalfa. La mortalidad por esta causa fue de un 23%. Las principales lesiones encontradas en la necropsia fueron enfisema y edema intersticial intenso del pulmón, lo cual fue corroborado histopatológicamente, encontrándos...

  10. Descripción de un brote de enfisema y edema pulmonar agudo del bovino (EPAB) en Parral (Chile)

    OpenAIRE

    H. URRUTIA; C. BREVIS; M. QUEZADA; S. DONOSO

    1997-01-01

    Se describe un brote de enfisema y edema alveolar agudo del bovino (EPAB) ocurrido en la zona centro-sur a fines del verano de 1995. Los animales Frisón negro, de aproximadamente 2 años de edad, fueron afectados después de cambiarse de una pradera fibrosa a una suculenta de alfalfa. La mortalidad por esta causa fue de un 23%. Las principales lesiones encontradas en la necropsia fueron enfisema y edema intersticial intenso del pulmón, lo cual fue corroborado histopatológicamente, encontrándose...

  11. Sistema informático para la gestión de la información hospitalaria del infarto agudo de miocardio (RHIMA)

    OpenAIRE

    Yanier Coll Muñoz; Francisco Valladares Carvajal; Jorge L. Fernández Curbelo; Ing. Luis E. Fernández Curbelo

    2015-01-01

    Introducción: La difícil recopilación de información sobre la prevalencia y desarrollo del infarto agudo de miocardio imposibilita medir la calidad del tratamiento durante la evolución de la enfermedad en un determinado grupo de pacientes.Objetivo: Desarrollar un sistema informático que permita la gestión de la información hospitalaria del infarto agudo de miocardio en el Servicio de Cardiología.Método: Se identificaron las variables necesarias para la confección del registro, divididas por b...

  12. Características clínicas y diagnósticas en infarto renal agudo en una serie clínica

    Directory of Open Access Journals (Sweden)

    C. Juan Alberto Fierro, Dr.

    2010-07-01

    Full Text Available El infarto renal agudo constituye un diagnóstico infrecuente. Ello puede deberse a que sus síntomas son similares a los de los cálculos renales o la pielonefritis aguda. Por esa razón, el síntoma cardinal de dolor de flanco debe ser investigado en forma muy acabada. Esta serie clínica revisa seis casos de infarto renal agudo vistos en esta institución durante el año 2007.

  13. Occurrence of uranium in the itabiritic iron ore of Morro Agudo on the NE border of the iron Quadrangle/Minas Gerais, Brasilien

    International Nuclear Information System (INIS)

    Guba, I.

    1982-01-01

    The precambrian itabirites and hematite ores of the Morro Agudo iron ore mine on the NE border of the Quadrilatero Ferrifero in Minas Gerais/Brazil contain uranium-bearing minerals and rare-earth elements. In association with phosphates they occupy planes of joints, fractures and cleavage in the area of amphibolitic schist which is intercalated in the s 1 -planes of the itabirites and hematite ores. Preliminary analyses of the uranium-bearing minerals were made by energy dispersive X-ray spectrometry and electron microscopy. The results are presented in connection with the lithologic and tectonic features of the Morro Agudo mine. (orig.) [de

  14. Consequências cardiovasculares na SAOS Cardiovascular consequences of obstructive sleep apnea syndrome

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    Geraldo Lorenzi Filho

    2010-06-01

    Full Text Available Uma condição clínica muito comum é SAOS, que está associada a várias doenças cardiovasculares, incluindo hipertensão arterial sistêmica, fibrilação atrial e aterosclerose. A associação entre SAOS e doença cardiovascular não é somente uma consequência da sobreposição de fatores de risco, incluindo obesidade, sedentarismo, ser do sexo masculino e ter idade maior. Existem evidências crescentes de que SAOS contribui de forma independente para o aparecimento e a progressão de várias doenças cardiovasculares. Os mecanismos pelos quais SAOS pode afetar o sistema cardiovascular são múltiplos e incluem a ativação do sistema nervoso simpático, inflamação sistêmica, resistência a insulina e geração de estresse oxidativo. Existem evidências que o tratamento de SAOS com CPAP pode reduzir a pressão arterial, sinais precoces de aterosclerose, risco de recorrência de fibrilação atrial e mortalidade, principalmente por acidente vascular cerebral e infarto agudo do miocárdio, em pacientes com SAOS grave.Obstructive sleep apnea syndrome (OSAS is a common condition associated with various cardiovascular diseases, including systemic arterial hypertension, atrial fibrillation, and atherosclerosis. The association between OSAS and cardiovascular disease has been related to the overlapping of risk factors, including obesity, having a sedentary lifestyle, being male, and being older. However, there is mounting evidence that OSAS can also independently contribute to the development and progression of various cardiovascular diseases. The mechanisms by which OSAS can affect the cardiovascular system are multiple, including the activation of the sympathetic nervous system, systemic inflammation, insulin resistance, and oxidative stress. There is also evidence that the treatment of OSAS with CPAP can reduce arterial blood pressure, early signs of atherosclerosis, the risk of atrial fibrillation recurrence, and mortality (principally

  15. Cardiovascular diseases

    International Nuclear Information System (INIS)

    Kodama, Kazunori

    1992-01-01

    This paper is aimed to discuss the involvement of delayed radiation effects of A-bomb exposure in cardiovascular diseases. First, the relationship between radiation and cardiovascular diseases is reviewed in the literature. Animal experiments have confirmed the relationship between ionizing radiation and vascular lesions. There are many reports which describe ischemic heart disease, cervical and cerebrovascular diseases, and peripheral disease occurring after radiation therapy. The previous A-bomb survivor cohort studies, i.e., the RERF Life Span Study and Adult Health Study, have dealt with the mortality rate from cardiovascular diseases, the prevalence or incidence of cardiovascular diseases, pathological findings, clinical observation of arteriosclerosis, ECG abnormality, blood pressure abnormality, and cardiac function. The following findings have been suggested: (1) A-bomb exposure is likely to be involved in the mortality rate and incidence of ischemic heart disease and cerebrovascular diseases; (2) similarly, the involvement of A-bomb exposure is considered in the prevalence of the arch of aorta; (3) ECG abnormality corresponding to ischemic heart disease may reflect the involvement of A-bomb exposure. To confirm the above findings, further studies are required on the basis of more accurate information and the appropriate number of cohort samples. Little evidence has been presented for the correlation between A-bomb exposure and both rheumatic heart disease and congenital heart disease. (N.K.) 88 refs

  16. HIV and Cardiovascular Disease

    Science.gov (United States)

    ... Select a Language: Fact Sheet 652 HIV and Cardiovascular Disease HIV AND CARDIOVASCULAR DISEASE WHY SHOULD PEOPLE WITH HIV CARE ABOUT CVD? ... OF CVD? WHAT ABOUT CHANGING MEDICATIONS? HIV AND CARDIOVASCULAR DISEASE Cardiovascular disease (CVD) includes a group of problems ...

  17. Caracterización del infarto agudo del miocardio en mujeres atendidas en el hospital Ernesto Guevara

    Directory of Open Access Journals (Sweden)

    Zailit González Cruz

    2014-08-01

    Full Text Available En Las Tunas han aumentado las cifras de mujeres afectadas por infarto agudo del miocardio (IMA, con una tasa de mortalidad superior a la media nacional. A pesar de ello, no existen estudios publicados que describan el comportamiento de esta entidad en las mujeres tuneras. Se realizó un estudio transversal descriptivo en el servicio de cardiología del hospital provincial de Las Tunas, “Dr. Ernesto Guevara de la Serna”, entre los años 2009 al 2011, con el objetivo de caracterizar el infarto agudo del miocardio en el sexo femenino. La muestra estuvo constituida por 181 mujeres admitidas en el servicio por esta entidad, diagnosticadas según los criterios establecidos. Para el análisis de los resultados se utilizó la estadística descriptiva, con valores absolutos y porcientos. En la muestra de estudio prevaleció el IMA CEST, de topografía anterior y no trombolizado. La disfunción ventricular izquierda constituyó la complicación más frecuente. Predominaron como factores de riesgo asociados la hipertensión arterial, las dislipidemias, el hábito de fumar y la diabetes mellitus.

  18. COMPARTIMENTAÇÃO DE UNIDADES GEOMORFOLÓGICAS DO MUNICÍPIO DE AGUDO-RS

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    Gerson Jonas Schirmer

    2013-12-01

    Full Text Available Este artigo apresenta um mapeamento geomorfológico do município de Agudo-RS, onde as unidades geomorfológicas representam a integração dos elementos físicos da área de estudo, frente aos processos envolvidos na organização da paisagem local. A metodologia é fundamentada nas contribuições da ciência geográfica, utilizando como ferramenta SIGs (Sistemas de Informação Geográfica.  Através de uma representação de síntese, foram definidos cinco unidades geomorfológicas, Rampas deColúvio-Aluvio do Rio Jacuí, Rampas de Colúvio-Alúvio de Arroios, Colinas Alúvio-Coluvionar, Colinas Vulcânicas do Planalto Serra Geral e Associação de Morros e Morrotes do Rebordo do Planalto, que caracterizam a paisagem do município de Agudo.

  19. Fisiopatología, evaluación y manejo del dolor agudo en pediatría

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    Tatiana Pabón-Henao

    2015-12-01

    Full Text Available El manejo del dolor agudo en los niños es deficiente, como lo afirma en el 2013 un estudio de la AMA (American Medical Association: la población pediátrica recibe entre 50% y 90% menos analgésicos que los adultos, es decir, no se tiene claridad en la fisiopatología, abordaje y manejo del dolor en los niños. El dolor puede clasificarse según su tiempo de duración, intensidad y mecanismo fisiopatoló-gico que lo desencadena (nociceptivo y neuropático. Teniendo en cuenta que la fisiopatología del dolor no varía con la edad pero sí como el paciente pediátrico lo manifieste, se requiere conocer el abordaje y manejo según su intensidad. Por lo tanto, el objetivo de esta revisión se enfoca en el estado del arte y en generar claridad de los aspectos críticos como son el conocimiento de la fisiopatología, valoración adecuada y el manejo no farmacológico y farmacológico del dolor agudo en pediatría.

  20. Mapping of micro and Small branch of industrial enterprises located in the cities of Agudo and Silveira Martins – RS

    Directory of Open Access Journals (Sweden)

    Carla Hartmann Sturm

    2016-06-01

    Full Text Available In the development of a country are the companies responsible for creating jobs, pay taxes and thus cause the economic and regional development. In Brazil, most of these institutions is made up of micro enterprises and small that often struggling to survive in the market. Therefore, it is necessary investments and public incentives to encourage their development making them competitive. In this sense, this article aims to develop a mapping of micro and small enterprises in the industrial sector in the cities of Agudo and Silveira Martins – Rio Grande do Sul (RS. For this, we used a descriptive research on the purposes and literature as to the means being prepared a questionnaire for collecting data from the sample studied. As results obtained ten micro companies and three small businesses were found in Agudo – RS, and the main industries are the timber industry and the manufacture of bakery products, influenced 65.5% of the employees of micro and small companies analyzed in the municipality. Already in Silveira Martins – RS were found seven micro and small enterprises, where six are classified as micro company and only one as small business. It was found also that the main industrial branch is the timber sector (six companies, in which 96% of employees work in any activity related to wood processing.

  1. Cardiovascular system

    International Nuclear Information System (INIS)

    Soulen, R.L.; Grosh, J.

    1984-01-01

    Invasive cardiovascular diagnostic procedures involve a finite risk and therefore can be recommended only when the benefit appears to exceed the risk by a substantial margin. The risk/benefit ratio varies not only with the procedure concerned but with the status of the vascular system, concomitant diseases, and the risks of both the suspected illness and its treatment. The risks inherent in the procedures per se are detailed in the sections to follow

  2. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    Science.gov (United States)

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  3. EFECTO AGUDO DEL EJERCICIO FISICO EN LA INTELIGENCIA Y LA MEMORIA EN HOMBRES, SEGUN LA EDAD

    Directory of Open Access Journals (Sweden)

    Yorleny Alfaro Chavarría

    2001-12-01

    Full Text Available Con muy diversas investigaciones se han demostrado los efectos agudos del ejercicio físico en los procesos cognitivos (memoria, inteligencia, tiempo de reacción, creatividad, etc. según la edad. Sin embargo, gran cantidad de variables se ven involucradas en los diferentes tratamientos. Es, por esto, que se pretendió realizar una investigación específica y homogénea, de manera que los cambios obtenidos en la inteligencia y la memoria en las diferentes edades se deban al tratamiento en sí, y no a la influencia de otros factores. Para esto, se aplicó un tratamiento que consistió en realizar ejercicio aeróbico subiendo y bajando una grada de 27 cm. de alto x 30 cm. de ancho, durante 10 minutos, a una intensidad del 60% de la frecuencia cardíaca máxima. Los sujetos fueron 100 hombres con edades entre la niñez y la edad avanzada. Se ubicaron en 5 subgrupos que realizaron un 'pretest', el tratamiento indicado y un 'postest'. Las pruebas fueron el test de Raven para la inteligencia y el Verbal Script Digit Span para medir la memoria auditiva. Para conocer los resultados se realizó un análisis de varianza Anova 5x2x2 para grupos independientes, utilizando los puntajes obtenidos en las diferencias entre 'pretest' y 'postest', para ambas variables, con su respectivo 'post-hoc' en los casos requeridos. Y para determinar la magnitud del cambio, se obtuvo los tamaños del efecto. Se encontró que con ejercicio aeróbico submaximal, la totalidad de los grupos etarios mejoraron sus resultados en el test de memoria con mejor resultado los de edades promedio de 25.5 y 63.25 años. Para la variable de inteligencia los sujetos de 34.75 y 52.4 años en promedio lograron los mejores resultados, mientras que los jóvenes de 25.5 años y los adultos mayores no tuvieron cambio significativo en este aspecto.

  4. Cardiovascular risk assessment in hypertensive patients Evaluación del riesgo cardiovascular en hipertensos Avaliação do risco cardiovascular em hipertensos

    Directory of Open Access Journals (Sweden)

    Elaine Amaral de Paula

    2013-06-01

    Full Text Available OBJECTIVE: to assess cardiovascular risk by means of the traditional Framingham score and the version modified through the incorporation of emerging risk factors, such as family history of acute myocardial infarction, metabolic syndrome and chronic kidney disease. METHOD: participants were 50 hypertensive patients under outpatient treatment. The clinical data were collected through a semi-structured interview and the laboratory data from patients' histories. RESULTS: it was verified that the traditional Framingham score was predominantly low (74%, with 14% showing medium risk and 12% high risk. After the inclusion of emerging risk factors, the chance of a coronary event was low in 22% of the cases, medium in 56% and high in 22%. CONCLUSIONS: the comparison between the traditional Framingham risk score and the modified version demonstrated a significant difference in the cardiovascular risk classification, whose correlation shows discreet agreement between the two scales. Lifestyle elements seem to play a determinant role in the increase in cardiovascular risk levels. OBJETIVO: evaluar el riesgo cardiovascular utilizando el puntaje de Framingham tradicional y el modificado por la incorporación de factores de riesgo emergentes como historia familiar de infarto agudo del miocardio, síndrome metabólico y enfermedad renal crónica. MÉTODO: participaron 50 hipertensos que hacen tratamiento en ambulatorio. Los datos clínicos fueron obtenidos por medio de entrevista semiestructurada y los de laboratorio fueron obtenidos de fichas. RESULTADOS: se verificó que el puntaje de Framingham tradicional fue predominantemente bajo (74%, 14% presentó riesgo medio y 12% riesgo alto. Tras la inclusión de factores de riesgo emergentes, la probabilidad de ocurrir un evento coronario fue baja en 22% de los casos, media en 56% y alta en 22% de los casos. CONCLUSIONES: la comparación entre el puntaje de riesgo de Framingham tradicional y el modificado demostr

  5. Decúbito prono en pacientes con síndrome de distrés respiratorio agudo

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    Mariano Setten

    Full Text Available RESUMEN El síndrome de distrés respiratorio agudo ocupa gran atención en la unidad de cuidados intensivos. A pesar del amplio conocimiento alcanzado sobre la fisiopatología de éste síndrome, el enfoque en la unidad de cuidados intensivos consiste, en gran parte, en un tratamiento de soporte vital y en evitar los efectos secundarios de las terapéuticas invasivas. Si bien, durante los últimos 20 años, se generaron grandes avances en ventilación mecánica con un impacto importante sobre la mortalidad, ésta continúa siendo elevada. Una característica de los pacientes con síndrome de distrés respiratorio agudo, sobre todo los más severos, es la presencia de hipoxemia refractaria debido a la existencia de shunt, pudiendo requerir tratamientos adicionales a la ventilación mecánica, entre ellos la ventilación mecánica en decúbito prono. Este método, recomendado para mejorar la oxigenación por primera vez en 1974, puede ser implementado fácilmente en cualquier unidad de cuidados intensivos con personal entrenado. El decúbito prono tiene un sustento bibliográfico sumamente robusto. Varios ensayos clínicos randomizados han demostrado el efecto del decúbito prono sobre la oxigenación en pacientes con síndrome de distrés respiratorio agudo medida a través de la relación PaO2/FiO2 e incluso su impacto en el aumento de la sobrevida de estos pacientes. Los integrantes del Comité de Kinesiología Intensivista de la Sociedad Argentina de Terapia Intensiva realizaron una revisión narrativa con el objetivo de exponer la evidencia disponible en relación a la implementación del decúbito prono, los cambios producidos en el sistema respiratorio por la aplicación de la maniobra y su impacto sobre la mortalidad. Por último, se sugerirán lineamientos para la toma de decisiones.

  6. Diagnósticos de enfermería al alta hospitalaria en personas con Síndrome Coronario Agudo

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    Clara Inés Padilla García

    2017-04-01

    Full Text Available Introducción: Enfermería juega un rol fundamental en las diferentes etapas de la atención de las personas con síndrome coronario agudo, entre ellas el egreso hospitalario. Brindar cuidado acorde a las necesidades propias de estas personas, requiere de la identificación de los principales diagnósticos de enfermería. Objetivo: Determinar la prevalencia de diagnósticos de Enfermería de las personas con síndrome coronario agudo al momento del alta hospitalaria. Metodología: Estudio de corte transversal en 196 personas hospitalizadas por el evento de interés, se utilizó instrumento de valoración focalizada que evaluaba las características definitorias de los diagnósticos de enfermería: ansiedad, afrontamiento ineficaz, disposición para mejorar la religiosidad, disposición para mejorar los conocimientos, intolerancia a la actividad; los cuales fueron identificados como prioritarios según la literatura científica y por consenso de expertos. Para determinar la prevalencia de los diagnósticos se realizó análisis de definición y características definitorias. Resultados: Se evidenció como principal problema de la población de estudio los conocimientos deficientes, seguido de la intolerancia a la actividad y la ansiedad. De igual forma se logró identificar diagnósticos positivos como la disposición para mejorar los conocimientos y la religiosidad. Conclusiones: El presente trabajo nos permitió identificar necesidades reales y reconocer factores protectores al momento del alta hospitalaria en personas que han vivido un evento coronario agudo, lo cual constituye un punto de partida para el diseño de planes de cuidado y la puesta en marcha de intervenciones que conduzcan a mejorar la situación de salud de este grupo de personas.

  7. ANALISIS COSTE-EFECTIVIDAD DE DISTINTOS MÉTODOS DE DIAGNÓSTICO POR IMAGEN DEL TROMBOEMBOLISMO PULMONAR AGUDO

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    Stella Maris Batallés

    2009-01-01

    Full Text Available La técnica diagnóstica óptima para detectar tromboembolismo pulmonar agudo (TEP continúa en discusión. La gammagrafía pulmonar de ventilación/perfusión ha sido el examen preferido durante décadas, pero con el advenimiento de nuevas pruebas de imágenes las posibilidades diagnósticas se ampliaron, siendo necesario evaluarlas desde la perspectiva del coste y de la efectividad. El objetivo de este trabajo fue evaluar distintos métodos de diagnóstico por imagen para detectar TEP agudo para determinar el más coste-efectivo. Métodos. Análisis de coste-efectividad (CE empleando un árbol de decisiones para modelar distintas pruebas (centellograma V/Q, TC helicoidal, angiografía por tomografía computada multidetector (TCMD, resonancia magnética por imágenes (RMI y arteriografía convencional. Se obtuvieron valores de sensibilidad, especificidad, valor predictivo positivo (VPP y negativo (VPN de las pruebas diagnósticas. Resultado medido: "caso detectado de TEP". Los costes evaluados fueron los directos, expresados en euros (t, incluyendo los secundarios a las complicaciones de los métodos diagnósticos. Se realizó un análisis de sensibilidad de una vía para evaluar la robustez de las conclusiones. Resultados. No se eliminaron pruebas por dominancia extendida. La tasa cruda de CE para TCMD fue de 486 t por cada caso de TEP detectado. El coste marginal entre la TC helicoidal y el centellograma V/Q fue de 103 t para detectar 8 casos adicionales de TEP, mientras que el coste marginal entre la TCMD y la TC helicoidal fue de 229 t para detectar un caso adicional de TEP. Conclusiones. La prueba diagnóstica más coste-efectiva fue la TCMD, hallazgo que mostró robustez en el análisis de sensibilidad. Sin embargo, el análisis de C-E incremental nos mostró que la TCMD costó 229 t más respeto a la TC helicoidal para lograr una mínima mejora en la efectividad de la prueba (detección de TEP agudo. El alto valor predictivo negativo de

  8. Qualidade de vida de clientes pós-infarto agudo do miocárdio Calidad de vida de los clientes pós-infarto agudo del miocardio Client's quality of life after myocardial infarction

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    Joselany Afio Caetano

    2007-03-01

    Full Text Available Objetivou-se neste estudo avaliar a qualidade de vida de clientes que sofreram infarto agudo do miocárdio. A amostra constou de 30 clientes selecionados pela busca em prontuários de uma unidade cardiológica, que nos permitiu a identificação e localização desses clientes, internados no ano de 2004. Para coleta de dados utilizamos a Escala de Qualidade de Vida de Flanagan e o tratamento estatístico com desvio-padrão. Os resultados mostraram maior índice de respostas nos níveis "indiferentes" a "pouco satisfeitos" em suas qualidades de vida. A relação interpessoal apresentou o mais alto índice de satisfação, contrariando o bem-estar físico e material, com o mais baixo índice de satisfação. Concluiu-se que a avaliação da qualidade de vida de clientes que sofreram infarto agudo do miocárdio se mostra comprometida, o que vem corroborar outros estudos anteriormente realizados.El objetivo del estudio fue evaluar la calidad de vida de los clientes que han sufrido infarto agudo del miocardio. La muestra ha consistido de 30 pacientes escogidos por la búsqueda en historias clínicas de una unidad cardiológica, que nos permitió la identificación y localización de estos clientes, internados en el año 2004. Para la colecta de los datos utilizamos la Escala de Calidad de Vida de Flanagan y el tratamiento estadístico con desvío medio. Los resultados muestran mayor índice de respuestas en los niveles "indiferentes" a "poco satisfechos" en sus calidades de vida. La relación interpersonal presentó el más alto índice de satisfacción, contrariando el bienestar físico y material, con el más bajo índice de satisfacción. Ha concluído que la evaluación de la calidad de vida de clientes que sufrieron infarto agudo del miocardio muéstrase comprometida, lo que viene a confirmar otros estudios anteriormente realizados.This study evaluates the quality of life of clients who suffered myocardial infarction. The sample consisted of 30

  9. Efeito Agudo da Pressao Positiva Continua sobre a Pressao de Pulso na Insuficiencia Cardiaca Cronica

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    Monica Quintao

    2014-03-01

    Full Text Available Fundamento: Pacientes com insuficiência cardíaca (IC apresentam disfunção ventricular esquerda e redução da pressão arterial média (PAM. O aumento do estímulo adrenérgico causa vasoconstrição e resistência dos vasos, mantendo a PAM, enquanto aumenta a resistência vascular periférica e a rigidez dos vasos condutores. O aumento da pressão de pulso (PP reflete a complexa interação do coração com os sistemas arteriais e venosos. O aumento da PP é um importante marcador de risco em pacientes com insuficiência cardíaca crônica (ICC. A ventilação não invasiva (VNI tem sido utilizada para IC aguda descompensada para melhorar a congestão e a ventilação pelos efeitos respiratórios e hemodinâmicos. No entanto, nenhum desses estudos relatou o efeito da VNI na PP. Objetivo: O objetivo deste estudo foi determinar os efeitos agudos da VNI com CPAP (pressão positiva contínua nas vias aéreas sobre a PP em pacientes ambulatoriais com ICC. Métodos: Seguindo um protocolo randomizado, duplo-cego, cruzado e controlado com placebo, 23 pacientes com ICC (17 homens, 60 ± 11 anos, IMC 29 ± 5 kg/cm2, classes II e III da NYHA foram submetidos à CPAP via máscara nasal durante 30 minutos na posição reclinada. A pressão da máscara foi de 6 cmH2O, enquanto o placebo foi fixado em 0-1 cmH2O. PP e outras variáveis hemodinâmicas não invasivas foram avaliadas antes, durante e depois do placebo e do modo CPAP. Resultados: A CPAP diminuiu a frequência cardíaca de repouso (pré: 72 ± 9; pós 5 min: 67 ± 10 bpm , p < 0,01 e PAM (CPAP: 87 ± 11; controle 96 ± 11 mmHg , p < 0,05 pós 5 min. A CPAP diminuiu a PP (CPAP: 47 ± 20 pré para 38 ± 19 mmHg pós; controle: 42 ± 12 mmHg, pré para 41 ± 18 pós p < 0,05 pós 5 min. Conclusão: A VNI com CPAP diminuiu a pressão de pulso em pacientes com ICC estável. Ensaios clínicos futuros devem investigar se esse efeito está associado com melhora no desfecho clínico.

  10. EFEITO AGUDO DOS EXERCÍCIOS INTERMITENTES SOBRE A GLICEMIA DE ADOLESCENTES COM DIABETES TIPO 1

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    Valderi Abreu de Lima

    Full Text Available RESUMO Introdução: O exercício físico é um fator importante do tratamento do diabetes mellitus. Objetivo: Verificar o efeito agudo dos exercícios intermitentes sobre glicemia e oxidação de substratos energéticos em adolescentes com diabetes tipo 1. Métodos: Foram avaliados 10 adolescentes diabéticos com idade entre 10 e 15 anos. Foram avaliadas as medidas antropométricas, hemoglobina glicosilada (HbA1c, VO2máx e o teste de exercício intermitente. Nesse teste, os indivíduos permaneceram pedalando por 30 minutos em cicloergômetro com carga de 60% do VO2máx, intercalados com tiros de intensidades máximas de 10 segundos a cada 5 minutos. Os substratos energéticos foram avaliados durante o teste e a glicemia capilar foi medida antes, imediatamente após o exercício e 30 minutos depois. Foi observada redução média da glicemia de 39,2 ± 41,92 mg/dl, isto é, média de 21,61% da glicemia inicial. Ocorreu diferença significativa (0,0001 entre os substratos energéticos oxidados, com predominância da utilização de CHO. Há uma forte correlação direta entre a HbA1c e o escore z do IMC (r = 0,821, p = 0,004 e entre HbA1c e glicose observadas pós-exercício (r = 0,702, p = 0,024 e também há forte correlação entre os níveis de glicose pré-exercício e pós-exercício (r = 0,851, p = 0,002 e entre pós-exercício e 30 minutos depois do exercício (r = 0,874, p = 0,001. O teste de regressão linear mostrou que o escore z do IMC explica 67% dos valores de HbA1c (r² = 0,675. Resultados: De acordo com os resultados observados, 30 minutos de exercícios aeróbicos intermitentes intercalados com tiros curtos de 10 segundos promovem redução média de 21% da glicemia, com tendência de aumento na fase de recuperação. O substrato energético predominante na atividade são os carboidratos (CHO. Conclusão: Quanto melhor for o escore z do IMC do adolescente, espera-se melhor controle glicêmico em adolescentes com diabetes tipo 1.

  11. ESTRUTURA E VÍNCULOS DE UMA FAMÍLIA APÓS INFARTO AGUDO DO MIOCÁRDIO

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    Garcia, Raquel Pötter; Budó, Maria de Lourdes Denardin; Viegas, Aline da Costa; Cardoso, Daniela Habekost; Schwartz, Eda; Muniz, Rosani Manfrin

    2015-01-01

    Introdução: Conhecer os vínculos e a estrutura de uma família após episódio de Infarto Agudo do Miocárdio. Materiais e Métodos: Pesquisa qualitativa e exploratória que representa um estudo de caso desenvolvido com uma das famílias participantes. A coleta de dados ocorreu no período de fevereiro a maio de 2012, por meio de observação no domicílio e entrevista com construção do genograma e ecomapa. A intensidade dos vínculos foi definida pela família conforme legenda do ecomapa. Resultados e Di...

  12. Efeitos agudos do exercício resistido sobre marcadores da resposta inflamatória e imune

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    Guilherme Borges Pereira

    2012-01-01

    O objetivo dos pesquisadores do presente estudo foi examinar os efeitos agudos do Exercício Resistido (ER) sobre a apoptose (Anexina V+) e a migração (CX3CR1) de linfócitos T CD4+ e CD8+. 12 sujeitos adultos realizaram duas sessões de ER (3 séries em 9 exercícios) com 1 minuto (Hiper-1) e 3 minutos (Hiper-3) de intervalo entre as séries e exercícios. Não foi observada alteração significativa na contagem celular de linfócitos CD4+ e CD8+ após os protocolos Hiper-1 e Hiper-3 (p > 0,05). Foi obs...

  13. SÍNDROME CORONARIO AGUDO DE CAUSA NO ATEROESCLERÓTICA / Acute coronary syndrome of non-atherosclerotic origin

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    Yuri Medrano Plana

    2013-10-01

    Full Text Available Resumen La embolia coronaria es una causa poco frecuente de síndrome coronario agudo. Dentro de los varios tipos de material embólico se encuentra el de origen tumoral. Estos émbolos pueden ocasionar isquemia miocárdica de intensidad variable, desde angina de pecho hasta infarto agudo de miocardio o incluso, muerte súbita. Se presenta una mujer de 58 años de edad, que presentó episodios de angina inestable con cambios eléctricos sin factores de riesgo y sin antecedentes de cardiopatía isquémica, que en la coronariografía se demostró la presencia de arterias coronarias normales. El ecocardiograma transesofágico informó imagen ecogénica polilobulada y pediculada hacia la superficie septal de la aurícula izquierda (posible mixoma, sin observarse trombos en las cavidades cardíacas. La paciente fue operada (exéresis quirúrgica del tumor, evolucionó favorablemente y fue trasladada a su hospital de origen 72 horas después. / Abstract Coronary embolism is a rare cause of acute coronary syndrome. Among the various types of embolic material is that of tumoral origin. These emboli can cause myocardial ischemia of varying intensity, from angina to acute myocardial infarction or even sudden death. The case of a 58-year-old woman who presented unstable angina episodes with electrical changes with no risk factors and no history of ischemic heart disease is presented. By means of coronary angiography, the presence of normal coronary arteries was showed. Transesophageal echocardiography showed the echogenic polylobulated and pedicled image towards the septal surface of the left atrium (possible myxoma; thrombi in the cardiac chambers were not observed. The patient underwent surgery (surgical removal of the tumor, had a good progress and was transferred to her hospital of origin 72 hours later.

  14. O que todo intensivista deve saber a respeito da síndrome do desconforto respiratório agudo e dano alveolar difuso?

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    Fernando Rios

    2017-09-01

    Full Text Available RESUMO A síndrome do desconforto respiratório agudo é um desafio para o intensivista. A característica principal desta doença aguda é o dano alveolar difuso, presente em cerca de metade dos pacientes com a síndrome. É claro que o suporte respiratório à síndrome do desconforto respiratório agudo tem melhorado gradualmente nas últimas décadas. É também evidente que todos estes procedimentos são benéficos, já que reduzem a lesão pulmonar e mantêm o paciente vivo. Isto deve ser interpretado como uma estratégia de ganho de tempo, até que o fator desencadeante ou de risco causal melhore, assim como a tempestade inflamatória diminua e o pulmão se cure. Por outro lado, todos - exceto dois tratamentos farmacológicos (bloqueadores neuromusculares e esteroides - são incapazes de melhorar o desfecho da síndrome do desconforto respiratório agudo. A hipótese de que os resultados farmacológicos negativos podem ser explicados pela heterogeneidade histológica da síndrome do desconforto respiratório agudo tem sido apoiada pelas recentes demonstrações de que a síndrome com dano alveolar difuso tem característica clínico-patológica específica. O dano alveolar difuso é um diagnóstico patológico, e a biópsia pulmonar a céu aberto (a técnica mais comum para obtenção de tecido pulmonar tem efeitos colaterais graves, sendo necessário que se desenvolvam biomarcadores substitutos para o dano alveolar difuso. O objetivo desta revisão é discutir três tópicos relacionados à síndrome do desconforto respiratório agudo: o relacionamento entre a síndrome do desconforto respiratório agudo e o dano alveolar difuso; como o dano alveolar difuso pode ser representado no quadro clínico; e como o enriquecimento pode melhorar os resultados de estudos clínicos farmacológicos realizados com pacientes com a síndrome e com dano alveolar difuso.

  15. Manifestaciones cardiovasculares de anemia de células falciformes

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    Fernando Manzur

    2015-07-01

    Full Text Available La anemia de células falciformes es una hemoglobinopatía hereditaria producida por la presencia de hemoglobina S, que disminuye la solubilidad y a través del proceso de polimerización da lugar a hematíes en forma de hoz que obstruyen la red microvascular. Se caracteriza por episodios de daño por isquemia-reperfusión que contribuyen a la disfunción de órganos vitales. El advenimiento de la terapia inductora de hemoglobina fetal, asociada a la profilaxis antibiótica, ha permitido prolongar la supervivencia. Sin embargo, al incrementar la longevidad, las complicaciones cardiovasculares se hacen evidentes con el desarrollo de vasculopatía sistémica, infarto agudo de miocardio, hipertensión arterial pulmonar y disfunción ventricular. El objetivo de este artículo es revisar la fisiopatología y el tratamiento de las principales manifestaciones cardiovasculares en pacientes con anemia de células falciformes.

  16. Efecto de un tratamiento intensivo con insulina sobre la reactividad plaquetaria en pacientes con hiperglucemia que ingresan con un síndrome coronario agudo

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    Vivas Balcones, Luis David

    2011-01-01

    El objetivo primario de este trabajo ha sido la valoración del efecto que produce el control estricto de la glucemia mediante un tratamiento intensivo y precoz con insulina sobre la reactividad plaquetaria durante la fase hospitalaria en pacientes que ingresan en una unidad de cuidados intensivos cardiológicos con un síndrome coronario agudo e hiperglucemia, respecto a un tratamiento convencional.

  17. Diagnóstico automático del síndrome coronario agudo utilizando un sistema multiagente basado en redes neuronales

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    John Jaime Sprockel Díaz

    2017-05-01

    Conclusiones: Es posible desarrollar una herramienta para el diagnóstico automático del síndrome coronario agudo a partir de un sistema multiagente que ensamble la disposición tomada por un conjunto de redes neuronales artificiales, cuyo rendimiento permite su consideración para su implementación dentro de un sistema de soporte a las decisiones clínicas.

  18. Hematologia de tilápia-do-nilo alimentada com suplemento à base de algas frente a desafios de estresse agudo e crônico

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    F. Garcia

    2012-02-01

    Full Text Available Avaliou-se o efeito da suplementação com produto à base de algas, ergosan, em dietas para tilápias Oreochromis niloticus, submetidas ao desafio de estresse agudo e crônico sobre as características hematológicas. O ensaio foi realizado com tilápias jovens (15g em caixas de 500L de capacidade de estocagem, em sistema com recirculação da água, com fluxo constante, na densidade de 35 peixes por caixa. Os peixes foram alimentados com as dietas-teste durante 10 dias e, ao final deste período, voltaram a receber dieta isenta de ergosan, quando foram submetidos aos desafios de estresses agudo e crônico. Utilizou-se o delineamento inteiramente ao acaso (DIC, em esquema fatorial 4x2, sendo testados: quatro porcentagens do suplemento 0; 0,25; 0,5 e 1% de ergosan na ração em dois tipos de estresse, agudo e crônico. Os resultados permitem concluir que os estímulos de estresse aplicados foram capazes de provocar alterações fisiológicas nos peixes, incluindo redução no número de eritrócitos, eritroblastos e leucócitos e aumento do volume corpuscular médio dos eritrócitos. A administração oral de 1% de suplemento durante 10 dias para juvenis de tilápia-do-nilo, em condição de estresse agudo, induz o incremento de 69% no número de trombócitos circulantes.

  19. Modelos de serviços hospitalares para casos agudos em idosos Hospital services for acute care of elderly people

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    João Macedo Coelho Filho

    2000-12-01

    Full Text Available Embora a atenção ao idoso seja uma prioridade emergente no Brasil, pouca ênfase tem sido dada a modelos de organização de serviços hospitalares para pacientes geriátricos. São revisados modelos de serviços hospitalares para admissão e manuseio de casos agudos em idosos, com ênfase na discussão sobre o papel e o posicionamento da medicina geriátrica (incluindo sua interface com especialidades e com a clínica médica no âmbito da atenção hospitalar. Foi realizada pesquisa na base de dados Medline (1989-1999, bem como nos principais livros-texto de geriatria e de gerontologia, buscando identificar descrições de serviços hospitalares para cuidado agudo de pacientes idosos. As características dos modelos identificados foram compiladas e descritas à luz de sua adequação à realidade dos serviços de saúde no Brasil. Exemplos de intervenções em geriatria, com efetividade demonstrada através de revisões sistemáticas, foram também citadas. Os modelos mais freqüentemente relatados foram cuidado prolongado, tradicional, baseado na idade cronológica, não especializado e integrado. Adaptações e variantes de alguns desses modelos foram freqüentemente relatadas, assim como seu impacto potencial na efetividade do cuidado geriátrico. Evidências sobre o melhor modelo a seguir não foram identificadas, mas aqueles modelos favorecendo a integração da geriatria com a clínica geral pareceram mais adequados à nossa realidade. Ressalta a necessidade de reestruturação de serviços de saúde para responder às novas demandas que surgem com o envelhecimento da população, bem como do delineamento de serviços hospitalares para casos agudos, importantes para a efetividade do cuidado geriátrico e que devem ser objeto de maior debate e pesquisa no Brasil.Although the implementation of geriatric services is an emerging priority in Brazil, little emphasis has been put on the type of acute care that should be provided for elderly

  20. EFEITO AGUDO DO LASER DE BAIXA POTÊNCIA NA FADIGA DO BÍCEPS BRAQUIAL DE ATLETAS DE VOLEIBOL

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    Juliana Lôbo Froio

    Full Text Available RESUMO Introdução: A laserterapia de baixa potência tem entre seus propósitos auxiliar a recuperação de tecidos biológicos, atenuando os efeitos da fadiga muscular e contribuindo com a melhora do desempenho em atletas. Aspectos metodológicos ainda limitam as conclusões do efeito agudo da laserterapia sobre o desempenho muscular. Objetivo: Verificar o efeito agudo do laser terapêutico de baixa potência na fadiga induzida do bíceps braquial de atletas de voleibol. Métodos: Este foi um estudo randomizado e duplo-cego, aprovado pelo Comitê de Ética da UNESP de Marília. Participaram do estudo 19 atletas de voleibol de ambos os sexos. Realizou-se coleta de dados eletromiográficos do músculo bíceps braquial no exercício isométrico de flexão de cotovelo antes e após a aplicação do laser terapêutico. Um haltere com 75% do pico de força, obtido por uma célula de carga, foi utilizado para o protocolo de fadiga. Em seguida, os voluntários foram submetidos à aplicação do laser (ativo ou placebo em seis pontos do músculo bíceps braquial. Os dados eletromiográficos foram analisados no domínio da frequência, utilizando-se o software Myosystem®. Verificou-se a distribuição de normalidade dos dados pelo teste de Shapiro-Wilk, e utilizou-se Anova (split plot de medidas repetidas a fim de testar a interação entre tempo e grupo. Resultados: Para nenhuma das variáveis analisadas foi observada interação significativa entre grupo e tempo, indicando que o grupo irradiado não apresentou vantagens com relação ao grupo placebo. Conclusão: Após o protocolo de fadiga proposto, uma única aplicação de laser de baixa potência não foi suficiente para produzir efeitos positivos no desempenho de força e no sinal eletromiográfico do músculo bíceps braquial de atletas de voleibol.

  1. Terapia com células-tronco na síndrome do desconforto respiratório agudo Stem cell therapy in acute respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Tatiana Maron-Gutierrez

    2009-03-01

    Full Text Available A síndrome do desconforto respiratório agudo é caracterizada por uma reação inflamatória difusa do parênquima pulmonar, podendo ser induzida por um insulto direto ao epitélio alveolar (síndrome do desconforto respiratório agudo pulmonar ou indireto através do endotélio vascular (síndrome do desconforto respiratório agudo extrapulmonar. Acredita-se que uma terapia eficaz para o tratamento da síndrome do desconforto respiratório agudo deva atenuar a resposta inflamatória e promover adequado reparo da lesão pulmonar. O presente artigo apresenta uma breve revisão acerca do potencial terapêutico das células-tronco na síndrome do desconforto respiratório agudo. Essa revisão bibliográfica baseou-se em uma pesquisa sistemática de artigos experimentais e clínicos sobre terapia celular na síndrome do desconforto respiratório agudo incluídos nas bases de dados MedLine e SciELO nos últimos 10 anos. O transplante de células-tronco promove melhora da lesão inflamatória pulmonar e do conseqüente processo fibrótico, induzindo adequado reparo tecidual. Dentre os mecanismos envolvidos, podemos citar: diferenciação em células do epitélio alveolar e redução na liberação de mediadores inflamatórios e sistêmicos e fatores de crescimento. A terapia com células-tronco derivadas da medula óssea pode vir a ser uma opção eficaz e segura no tratamento da síndrome do desconforto respiratório agudo por acelerar o processo de reparo e atenuar a resposta inflamatória. Entretanto, os mecanismos relacionados à atividade antiinflamatória e antifibrogênica de tais células necessitam ser mais bem elucidados, limitando, assim, o seu uso clínico imediato.Acute respiratory distress syndrome is characterized by an acute pulmonary inflammatory process induced by the presence of a direct (pulmonary insult that affects lung parenchyma, or an indirect (extrapulmonary insult that results from an acute systemic inflammatory response

  2. El sobrepeso es el factor determinante en la presentación de síndrome coronario agudo en adultos jóvenes colombianos Overweight is a determinant factor in the presentation of acute coronary syndrome in colombian young adults

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    Sandra Y Silva

    2008-12-01

    Full Text Available Antecedentes: la obesidad es un factor de riesgo para un primer infarto agudo del miocardio. La enfermedad coronaria prematura genera gran impacto socioeconómico por los años productivos perdidos, lo que hace importante su prevención y tratamiento. Objetivo: evaluar el impacto de la obesidad y otros factores de riesgo convencionales en la presentación de un primer evento coronario agudo en sujetos menores de 50 años. Métodos: estudio transversal que incluyó pacientes con diagnóstico de síndrome coronario agudo que ingresaron a la institución entre febrero de 2002 y febrero de 2007. La población se dividió en: sujetos menores y mayores de 50 años, estos últimos seleccionados de manera aleatoria en relación 1:1. La información demográfica, la historia cardiovascular y los factores de riesgo se identificaron en la historia clínica electrónica de la institución y y se corroboraron por vía telefónica. Se empleó la prueba t de student o Wilcoxon rank-sum, según la distribución de las variables. Se realizó un análisis multivariado para determinar los factores de riesgo independientes. Un valor de p Background: obesity is a risk factor for developing a first myocardial infarct. Premature coronary disease generates a big socioeconomical impact due to productive years loss, which makes important its prevention and treatment. Objective: evaluate the impact of obesity and other conventional risk factors in the presentation of a first acute coronary event in subjects < 50 years. Methods: transversal study that included patients with diagnosis of acute coronary syndrome admitted to the institution between February 2002 and February 2007. The population was divided in subjects younger and older than 50 years, these last ones selected at random in a 1:1 relation. Demographic information, cardiovascular history and risk factors were identified in the institution’s electronic clinical history and were corroborated by telephone. The t

  3. Modificación de conocimientos en cardiópatas sobre rehabilitación cardiovascular Modification to knowledge of cardiovascular rehabilitation in heart disease patients

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    Arelis Guerra Santana

    2011-08-01

    Full Text Available Se desarrolló una intervención educativa para modificar conocimientos sobre rehabilitación cardiovascular, dada la alta prevalencia de pacientes con enfermedades del corazón: angina de pecho, infarto del miocardio agudo y cardiopatía hipertensiva. El estudio se efectuó en el Policlínico de Especialidades "Saturnino Lora" de Santiago de Cuba desde enero hasta junio de 2010 e incluyó a 20 trabajadores con alguna de las mencionadas cardiopatías. A los efectos se evaluaron las siguientes variables: concepto de rehabilitación cardiovascular, factores de riesgo, afecciones cardiovasculares más frecuentes, influencia del ejercicio físico y tratamiento. La estrategia didáctica aplicada logró modificar positivamente los conocimientos sobre el tema, lo cual fue comprobado 8 semanas después de realizado ese tipo de capacitación sobre una materia de salud tan importante.An educational intervention was performed to modify the knowledge of cardiovascular rehabilitation because of high prevalence of patients with heart diseases: angina pectoris, acute myocardial infarction and hypertensive heart disease. The study was carried out at "Saturnino Lora" Polyclinic of Specialties in Santiago de Cuba from January to June 2010 and included 20 workers with some of the above heart diseases. With this purpose the following variables were evaluated: concept of cardiovascular rehabilitation, risk factors, more frequent cardiovascular diseases, and influence of the physical exercise and treatment. The teaching strategy was able to positively modify the knowledge of the topic, which was checked 8 weeks after having completed this training on a very important health subject.

  4. Vivendo o acidente vascular encefálico agudo: significados da doença para pessoas hospitalizadas

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    Samia Jardelle Costa de Freitas Maniva

    2013-04-01

    Full Text Available Objetivou-se compreender o significado da experiência vivenciada pela pessoa adoecida por acidente vascular encefálico agudo. Trata-se de estudo qualitativo, fundamentado nos pressupostos teóricos do interacionismo simbólico, realizado em uma unidade especializada no tratamento de acidente vascular encefálico de um hospital terciário, situado na cidade de Fortaleza, CE. Participaram do estudo 10 pacientes. A coleta de dados ocorreu por meio de entrevista aberta e os dados foram organizados e analisados segundo a técnica de enunciação. Cumpriram-se todos os aspectos éticos. O significado da experiência de adoecimento foi construído com base na percepção dos sentimentos surgidos durante a hospitalização, caracterizados por medo da morte e das sequelas da doença; tristeza pelo distanciamento do lar; alívio, ao evidenciar-se melhora do quadro clínico, e desejo de mudança dos hábitos de vida. Apreendeu-se que a experiência de adoecimento por acidente vascular encefálico é complexa, e nela os significados são elaborados com base em sentimentos, ações e comportamentos dos sujeitos.

  5. Efeito agudo do método de facilitação neuromuscular proprioceptiva na flexibilidade de bailarinas

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    Giane Andreia Souza Siqueira

    2013-11-01

    Full Text Available Objetivo: Verificar a resposta aguda do método de Facilitação Neuromuscular Proprioceptiva (FNP na flexibilidade e a influência das variáveis idade, peso, estatura em praticantes de Ballet Clássico. Método: A amostra foi composta por 11 bailarinas, com média de idade de 10,91 ± 0,79 anos praticantes regularmente de Ballet clássico duas vezes por semana com no mínimo de 5 anos de experiência. Foi utilizado o método de FNP nas bailarinas. Para avaliação da flexibilidade foi utilizado o Banco de Wells. Para analise estatística utilizou o teste de “t” de Student para amostras dependentes e análise de regressão Stepwise Forward com p≤0,05. Resultado:A diferença média de amplitude de movimento foi 4,81 ± 1,99 cm. Já a variável estatura demonstrou-se influenciar significativamente na flexibilidade. O método FNP demonstrou efeito agudo significativo na flexão de quadril em bailarinas.

  6. Vivendo o acidente vascular encefálico agudo: significados da doença para pessoas hospitalizadas

    Directory of Open Access Journals (Sweden)

    Samia Jardelle Costa de Freitas Maniva

    Full Text Available Objetivou-se compreender o significado da experiência vivenciada pela pessoa adoecida por acidente vascular encefálico agudo. Trata-se de estudo qualitativo, fundamentado nos pressupostos teóricos do interacionismo simbólico, realizado em uma unidade especializada no tratamento de acidente vascular encefálico de um hospital terciário, situado na cidade de Fortaleza, CE. Participaram do estudo 10 pacientes. A coleta de dados ocorreu por meio de entrevista aberta e os dados foram organizados e analisados segundo a técnica de enunciação. Cumpriram-se todos os aspectos éticos. O significado da experiência de adoecimento foi construído com base na percepção dos sentimentos surgidos durante a hospitalização, caracterizados por medo da morte e das sequelas da doença; tristeza pelo distanciamento do lar; alívio, ao evidenciar-se melhora do quadro clínico, e desejo de mudança dos hábitos de vida. Apreendeu-se que a experiência de adoecimento por acidente vascular encefálico é complexa, e nela os significados são elaborados com base em sentimentos, ações e comportamentos dos sujeitos.

  7. Understanding cardiovascular disease

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000759.htm Understanding cardiovascular disease To use the sharing features on this page, ... lead to heart attack or stroke. Types of Cardiovascular Disease Coronary heart disease (CHD) is the most common ...

  8. APOE Genotyping, Cardiovascular Disease

    Science.gov (United States)

    ... Resources For Health Professionals Subscribe Search APOE Genotyping, Cardiovascular Disease Send Us Your Feedback Choose Topic At a ... help understand the role of genetic factors in cardiovascular disease . However, the testing is sometimes used in clinical ...

  9. Cardiovascular Disease and Diabetes

    Science.gov (United States)

    ... Peripheral Artery Disease Venous Thromboembolism Aortic Aneurysm More Cardiovascular Disease & Diabetes Updated:Jan 29,2018 The following ... clear that there is a strong correlation between cardiovascular disease (CVD) and diabetes. At least 68 percent ...

  10. Atención farmacéutica en personas que han sufrido episodios coronarios agudos (estudio TOMCOR

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    Álvarez de Toledo Flor

    2001-01-01

    Full Text Available Fundamento: Este estudio valora los efectos de un nuevo modelo de trabajo en las farmacias, denominado Atención Farmacéutica, frente al modelo tradicional. Se pretende conocer su factibilidad y las diferencias, potencialmente debidas a la Atención Farmacéutica, respecto de los resultados de salud de la farmacoterapia usada, en una muestra de pacientes que han sufrido episodios coronarios agudos. Métodos: Es un estudio prospectivo con un grupo de intervención (330 personas y un grupo control (405 personas, realizado en 83 farmacias de Asturias, Barcelona, Madrid y Vizcaya, en las que se hizo seguimiento durante un año del uso de medicamentos en 735 personas, de las cuales finalizaron el estudio 600. Resultados: Hubo diferencias favorables al grupo intervención, respecto de: a uso de servicios sanitarios indicativos de mayor morbilidad, tales como la frecuencia de consultas hospitalarias urgentes por paciente 1,27Interv. (IC95 %:1,10 a 1,44 y 1,63Contr.(IC95 %:1,36 a 1,90 o los días promedio de UCI por paciente hospitalizado: 2,46Interv.(IC95 %:1,56 a 3,36 y 5,87Contr.(IC95 %: 3,57 a 8,17, por causa cardiológica; b calidad de vida con diferencia de 4,7 (p < 0,05 en la dimensión de función física; c conocimiento de factores de riesgo de enfermedad coronaria, promedio de +10 % (p < 0,02 - 0,07, según dimensión; d identificación nominal de los medicamentos usados +10 % (p < 0,01; importancia subjetiva otorgada a los antiagregantes + 12 % (p < 0,009, los beta-bloqueantes, así como sus efectos +25 % (p < 0,02; y e satisfacción con la AF y percepción de la competencia profesional, promedio de + 12 % (p < 0,000 - 0,05, según dimensión. Conclusiones: Los valores menores de: demanda individual urgente coronaria, frecuencia de hospitalizaciones y número de días de Unidad de Cuidados Intensivos coronaria por hospitalización, sugerirían que los pacientes que tras un episodio coronario agudo reciben Atención Farmacéutica tienden a

  11. Atención farmacéutica en personas que han sufrido episodios coronarios agudos (estudio tomcor

    Directory of Open Access Journals (Sweden)

    Flor Álvarez de Toledo

    2001-01-01

    Full Text Available Fundamento: Este estudio valora los efectos de un nuevo modelo de trabajo en las farmacias, denominado Atención Farmacéutica, frente al modelo tradicional. Se pretende conocer su factibilidad y las diferencias, potencialmente debidas a la Atención Farmacéutica, respecto de los resultados de salud de la farmacoterapia usada, en una muestra de pacientes que han sufrido episodios coronarios agudos. Métodos: Es un estudio prospectivo con un grupo de intervención (330 personas y un grupo control (405 personas, realizado en 83 farmacias de Asturias, Barcelona, Madrid y Vizcaya, en las que se hizo seguimiento durante un año del uso de medicamentos en 735 personas, de las cuales finalizaron el estudio 600. Resultados: Hubo diferencias favorables al grupo intervención, respecto de: a uso de servicios sanitarios indicativos de mayor morbilidad, tales como la frecuencia de consultas hospitalarias urgentes por paciente 1,27Interv. (IC95 %:1,10 a 1,44 y 1,63Contr.(IC95 %:1,36 a 1,90 o los días promedio de UCI por paciente hospitalizado: 2,46Interv.(IC95 %:1,56 a 3,36 y 5,87Contr.(IC95 %: 3,57 a 8,17, por causa cardiológica; b calidad de vida con diferencia de 4,7 (p < 0,05 en la dimensión de función física; c conocimiento de factores de riesgo de enfermedad coronaria, promedio de +10 % (p < 0,02 - 0,07, según dimensión; d identificación nominal de los medicamentos usados +10 % (p < 0,01; importancia subjetiva otorgada a los antiagregantes + 12 % (p < 0,009, los beta-bloqueantes, así como sus efectos +25 % (p < 0,02; y e satisfacción con la AF y percepción de la competencia profesional, promedio de + 12 % (p < 0,000 – 0,05, según dimensión. Conclusiones: Los valores menores de: demanda individual urgente coronaria, frecuencia de hospitalizaciones y número de días de Unidad de Cuidados Intensivos coronaria por hospitalización, sugerirían que los pacientes que tras un episodio coronario agudo reciben Atención Farmacéutica tienden a

  12. Enfermedad cardiovascular en pacientes cubanos afectados por Ataxia de Friedreich.

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    Tania Cruz Mariño

    2010-01-01

    Full Text Available Al describir la ataxia de Friedreich, Nicholaus hizo referencia a la patología cardiaca. Esta enfermedad autosómica recesiva se debe a una mutación dinámica en el gen FRDA, codificándose deficientemente la proteína Frataxina, conduciendo a estrés oxidativo y muerte celular cardiaca. La presente investigación se desarrolló con el objetivo de describir las anomalías cardiovasculares presentes en los pacientes cubanos afectados por ataxia de Friedreich. A los individuos con diagnóstico molecular confirmatorio de la enfermedad se les realizó electrocardiograma y ecocardiograma, así como evaluación clínica mediante escalas validadas internacionalmente: ICARS y SARA. Los trastornos de repolarización ventricular difusos, los trastornos de conducción intraauricular, así como los trastornos de la función diastólica resultaron hallazgos frecuentes. El patrón restrictivo apreciado provee evidencia invivo de que la enfermedad conduce a disfunción diastólica del ventrículo izquierdo. La ocurrencia de un Infarto Agudo del Miocardio silente indica la importancia de identificar formas incipientes de afectación miocárdica.

  13. Daño pulmonar agudo relacionado con la transfusión (Trali y Bartonelosis aguda

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    Douglas López de Guimaraes

    2006-07-01

    Full Text Available Se presenta el caso de un varón de 22 años procedente de la periferia de la ciudad de Huaraz, Perú, que acude al Hospital "Victor Ramos Guardia" de Huaraz con un tiempo de enfermedad de 14 días, febril, pálido e ictérico, en el frotis de sangre periférica se encuentran formas bacilares de Bartonella bacilliformis en 99% de la lámina; se inicia tratamiento antibiótico con ceftriaxona y ciprofloxacino. Al día siguiente se le indica transfusión de dos paquetes globulares (puesto que tenía 6,2 g/dL de Hb, dos horas después presenta dolor toráxico, tos seca exigente, vómitos, dificultad respiratoria y cianosis, en la auscultación se encuentran roncantes y crepitantes, la radiografía de tórax muestra infiltrado alveolar difuso a predominio derecho. Es trasladado a la UCI donde recibe oxígeno con máscara de reservorio, dopamina, corticoides y se inicia el monitoreo hemodinámico; responde en forma satisfactoria, sale de alta con frotis negativo a Bartonella bacilliformis. Es el primer caso de daño pulmonar agudo relacionado con la transfusión (TRALI asociado con Bartonelosis aguda con cuadro clínico - radiológico y evolución compatible, es importante distinguir entre la complicación pulmonar debido a la sepsis grave por Bartonelosis aguda, que puede producir un cuadro clínico similar y el TRALI.

  14. Terapia ocupacional en un hospital general de pacientes agudos = Occupational therapy in a general hospital for acute pacients

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    Ocello, M. G

    2006-09-01

    Full Text Available RESUMEN Desde su creación, el Hospital Provincial “Dr. José María Cullen” posee la característica de ser un hospital de emergencias, sostenido por la Sociedad de Beneficencia y la Hermanas de la Caridad.Su funcionamiento responde a un Modelo Clínico-Asistencial, lo cual influye en la inserción de Terapia Ocupacional debiendo adaptar sus funciones a las características de la Institución.Los marcos de referencia teóricos y programas que se implementandeber ser acordes con las necesidades surgidas de un Hospital General de Agudos y de emergencias.En el Sector de Terapia Ocupacional se desarrolla la actividad docente cumpliendo con los requisitos reglamentados por el Ministerio de Salud de la Provincia de Santa Fe.ABSTRACT Ever since its start the Provincial Hospital “Dr. José María Cullen” is characterised for being an emergency hospital under the guidance of the Benfit Society of Hermanas de la Caridad.Its function responds to a Clinical Assistential Model, which influences the insertion of Occupational Therapy, adapting its functiones to the characteristics of the Institution as and when called for.The theoretical points of reference and programmes that are used must be in accordance with tehe necessities that appear in an Acute and Emergency General Hospital.In the Occupational Therapy Sector the teaching activity is developed as required by rules and regulations of the Ministry of Health for the Province of Santa Fe.

  15. Fibrilação atrial, infarto agudo do miocárdio e oclusão arterial aguda em paciente jovem com hipertireoidismo

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    Fabrício Thebit Bortolon

    2009-09-01

    Full Text Available Relato de caso de paciente jovem com hipertireoidismo não diagnosticado, apresentando quadro de fibrilação atrial, infarto agudo do miocárdio e oclusão arterial aguda de perna direita. Submetido à trombólise, embolectomia e iniciado tratamento para hipertireoidismo com tapazol. A evolução foi satisfatória, com reversão da alteração eletrocardiográfica isquêmica, melhora dos sintomas de oclusão arterial, controle do ritmo cardíaco e da função tireoidiana.

  16. Sistema informático para la gestión de la información hospitalaria del infarto agudo de miocardio (RHIMA

    Directory of Open Access Journals (Sweden)

    Yanier Coll Muñoz

    2015-10-01

    Full Text Available Introducción: La difícil recopilación de información sobre la prevalencia y desarrollo del infarto agudo de miocardio imposibilita medir la calidad del tratamiento durante la evolución de la enfermedad en un determinado grupo de pacientes.Objetivo: Desarrollar un sistema informático que permita la gestión de la información hospitalaria del infarto agudo de miocardio en el Servicio de Cardiología.Método: Se identificaron las variables necesarias para la confección del registro, divididas por bloques relacionados con la atención prehospitalaria, el síndrome coronario agudo, la atención en Unidades de Cuidados Coronarios y el egreso. Se creó un sistema informático que utiliza NetBeans como IDE de programación, Apache como servidor web y la base de datos en MySQL; como lenguaje de programación se utilizó PHP con la infraestructura digital (framework Yii del lado del servidor y JavaScript con el framework ExtJs 4.1.1 del lado del cliente. Como modelador de base de datos se utilizó ER/Studio.Resultados: Se conformó el Registro Hospitalario de Infarto Agudo de Miocardio (RHIMA para su aplicación en el Hospital Gustavo Aldereguía Lima de Cienfuegos, Cuba; se lograron obtener datos estadísticos inmediatos que permitieron realizar un análisis de la atención a los pacientes con esta enfermedad.Conclusiones: Se desarrolló un sistema informático web capaz de gestionar la información del IAM. Su diseño, acorde al Sistema Nacional de Salud de Cuba, tiene en cuenta las características epidemiológicas y demográficas de la población cubana y brindan indicadores de calidad en la terapéutica para el registro de la información del IAM, ajustadas a las recomendaciones de las principales Guías de Práctica Clínica.

  17. O problema do trabalho infantil na agricultura familiar: o caso da produção de tabaco em Agudo-RS

    Directory of Open Access Journals (Sweden)

    Joel Orlando Bevilaqua Marin

    2012-12-01

    Full Text Available O objetivo do artigo é analisar a emergência do problema do trabalho infantil no cultivo de tabaco em Agudo, desencadeado pela promulgação do Decreto n. 6.481/2008, que trata das piores formas de trabalho infantil. Os procedimentos metodológicos utilizados foram a revisão bibliográfica, pesquisa documental e um estudo de caso, realizado no município de Agudo, Rio Grande do Sul. No estudo de caso, procurou-se obter dados quantitativos e qualitativos, por meio de questionários e entrevistas abertas, dirigidos para 27 agricultores familiares fumicultores, com filhos com menos de 18 anos de idade. Os resultados da pesquisa indicam a existência de um confronto entre diferentes concepções sobre o trabalho da criança no âmbito da agricultura familiar. Os dispositivos legais, os termos de compromissos e os contratos de integração na cadeia produtiva do fumo proíbem o trabalho de menores de 18 anos, fundamentando-se nos princípios internacionais da garantia do pleno desenvolvimento das crianças. Na perspectiva das famílias, o trabalho das crianças é entendido como "ajuda", forma de socialização e formação dos herdeiros. Portanto, os pais não concordam que se trata de uma forma perversa de exploração do trabalho dos próprios filhos.The aim of this paper is to analyze the emergence of the child labor problem in tobacco growing in Agudo (Rio Grande do Sul state, triggered by the promulgation of Act 6.481/2008, which addresses the worst child labor conditions. The methodological procedures used were the literature review, desk research and a case study, conducted in the municipality of Agudo. In the case study, we have tried to obtain quantitative and qualitative data through questionnaires and open interviews directed to 27 tobacco growers, and with teenagers and children under 18 years old. The survey results indicate the existence of a clash between different conceptions of child labor in small scale family farmers. The legal

  18. Hiperalimentação enteral em traumatismos crânio-encefálicos agudos reposição ou dietoterapia?

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    Arthur Schelp

    1992-06-01

    Full Text Available Os autores apresentam revisão geral sobre a fisiopatogenia do trauma, ressaltando os estados de hipereatabolismo e hipermetabolismo, suas consequências nutricionais, com as particularidades do trauma encefálico. São feitas, também, considerações sobre as vias, composição e volumes das dietas enterais a serem administradas a pacientes com trauma agudo encefálico, assim como são apontadas questões a serem melhor elucidadas.

  19. Fluidoterapia entérica versus fluidoterapia endovenosa em casos de síndrome de abdómen agudo em equinos

    OpenAIRE

    Mancha, Dora Alexandra Inácio

    2009-01-01

    Dissertação de Mestrado Integrado em Medicina Veterinária O Síndrome de Abdómen Agudo é uma patologia muito frequentemente encontrada na prática clínica de equinos. A hidratação dos cavalos com dor abdominal aguda é extremamente importante. Por este motivo, a abordagem terapêutica médica destes animais inclui quase invariavelmente a administração de fluidos. O médico veterinário pode recorrer à fluidoterapia entérica e à fluidoterapia endovenosa para o tratamento destes animais...

  20. Mortalidad por enfermedad de Chagas: A propósito de los brotes de Chagas agudo como enfermedad reemergente de transmisión alimentaria

    OpenAIRE

    Rísquez, Alejandro

    2009-01-01

    Tras la ocurrencia de los primeros brotes de Chagas agudos en la capital (diciembre 2007) y Estado Vargas (marzo 2009) por trasmisión oral, se procedió a una revisión de la mortalidad por la enfermedad registrada entre 1997 y 2006, cuyos datos se analizaron de acuerdo a la edad, sexo y forma de presentación. El número absoluto de muertes sigue siendo elevado con promedio de 796 muertes anuales, de predominio en el sexo masculino, la mayoría en después de los 60 años de edad. Llama la atención...

  1. Efectos agudos de la actividad física y los videojuegos activos sobre las funciones cognitivas en jóvenes y adultos mayores

    OpenAIRE

    López García, Jesús

    2017-01-01

    La presente tesis doctoral consiste en intentar aportar nuevas evidencias científicas que traten de ampliar y clarificar el conocimiento existente referente a los efectos agudos de la actividad física aeróbica y los videojuegos activos sobre las funciones cognitivas en dos muestras poblacionales diferentes: los jóvenes adultos y los adultos mayores. Como síntesis general, podríamos indicar que el fin de las series experimentales desarrolladas en esta tesis tratan de estudiar si la práctic...

  2. Comportamiento del infarto agudo del miocardio en personas con diabetes mellitus de la provincia Granma Situation of the acute myocardial infarction in persons with diabetes mellitus in Granma province

    OpenAIRE

    Eduardo René Valdés Ramos; Marjoris Rivera Chávez; Niurka Bencosme Rodríguez

    2012-01-01

    Antecedentes: la diabetes mellitus, además de ser un factor de riesgo para el infarto agudo del miocardio, parece conferir per se un peor pronóstico en los pacientes con esta entidad. Objetivo: evaluar el comportamiento del infarto agudo del miocardio en personas con diabetes mellitus de la provincia de Granma. Métodos: se realizó un estudio transversal y descriptivo con 159 pacientes que ingresaron en la Unidad de Cuidados Intensivos Coronarios del Hospital "Carlos Manuel de Céspedes", de Ba...

  3. Copa do mundo de futebol como desencadeador de eventos cardiovasculares

    Directory of Open Access Journals (Sweden)

    Daniel Guilherme Suzuki Borges

    2013-06-01

    Full Text Available FUNDAMENTO: Síndromes coronarianas agudas são a maior causa de mortalidade no mundo. Estímulos externos, também conhecidos como gatilhos, como estado emocional ou atividade física, podem produzir mudanças fisiopatológicas desencadeantes. Dentre os gatilhos estudados, eventos estressantes, como campeonatos de futebol, são controversos na literatura e não há dados efetivos para a população brasileira. OBJETIVO: Avaliar os efeitos agudos do estresse ambiental induzido pelos jogos da Copa do Mundo de Futebol no aumento da incidência de doenças cardiovasculares no Brasil. MÉTODOS: Foram obtidos dados publicamente disponíveis do Sistema Único de Saúde referentes às internações hospitalares com código internacional de doenças, referentes às síndromes isquêmicas agudas, no período de maio a agosto de 1998 a 2010 (155.992 internações. Restringiu-se a análise aos pacientes maiores que 35 anos e internados por especialidades clínicas. Comparou-se a incidência de infarto e óbito entre os dias sem copa (Grupo I: 144.166; 61,7 ± 12,3 anos; 59,4%masculino, dias de copa sem jogos do Brasil (Grupo II: 9.768; 61,8 ± 12,3 anos; 60,0% masculino e dias de jogos do Brasil (Grupo III: 2.058; 61,6 ± 12,6 anos; 57,8% masculino. Utilizou-se regressão logística e de Poisson para ajustar por idade, gênero, densidade populacional e número de postos de atendimento. RESULTADOS: Houve aumento da incidência de infarto para jogos de copa do mundo (1,09; IC95% = 1,05-1,15 e do Brasil (1,16; IC95% = 1,06-1,27. Não houve impacto sobre mortalidade - copa (1,00; IC95% = 0,93-1,08 e Brasil (1,04; IC95% = 0,93-1,22. CONCLUSÃO: A copa do mundo e, especialmente, os jogos da seleção brasileira implicam maior incidência de infarto agudo do miocárdio, mas não de mortalidade intra-hospitalar.

  4. Síndrome pulmonar e cardiovascular por hantavírus Hantavirus pulmonary and cardiovascular syndrome

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    Mariangela Pimentel Pincelli

    2003-10-01

    Full Text Available A síndrome pulmonar e cardiovascular por hantavírus é uma doença de conhecimento relativamente recente e freqüentemente fatal, apresentando-se como síndrome do desconforto respiratório agudo. No Brasil, desde o primeiro surto, relatado em novembro/dezembro de 1993, em Juquitiba, 226 casos já foram registrados pela Fundação Nacional da Saúde. A doença afeta indivíduos previamente hígidos, apresentando-se com pródromo febril e sintomas semelhantes aos de um resfriado comum, podendo rapidamente evoluir para edema pulmonar, insuficiência respiratória aguda e choque. A hemoconcentração e a plaquetopenia são comuns da síndrome pulmonar e cardiovascular por hantavírus, e o quadro radiológico típico é de um infiltrado intersticial bilateral difuso, que progride rapidamente para consolidações alveolares, paralelamente à piora do quadro clínico. A mortalidade inicial era em torno de 75% e declinou para aproximadamente 35%, nos últimos anos. Os pacientes que sobrevivem geralmente recuperam-se completamente, cerca de uma semana após o estabelecimento do quadro respiratório. O agente causal, não reconhecido até há pouco, foi identificado como um hantavírus, cujo reservatório natural são animais roedores da família Muridae, subfamília Sigmodontinae. O tratamento específico antiviral ainda não é bem estabelecido, estando em estudo a eficácia de ribavirina. Cuidados de terapia intensiva como ventilação mecânica e monitoramento hemodinâmico invasivo são necessários nas formas mais graves da doença. Essas medidas, se instituídas precocemente, podem melhorar o prognóstico e a sobrevida dos pacientes com síndrome pulmonar e cardiovascular por hantavírus.Hantavirus pulmonary and cardiovascular syndrome is a recently identified and often fatal disease, which presents as acute respiratory distress syndrome (ARDS. Since the first outbreak, in Nov/Dec 1993, in Juquitiba, Brazil, 226 cases have been registered by

  5. Miocárdio não compactado em paciente com infarto agudo do miocárdio Miocardio no compactado en paciente con infarto agudo de miocardio Noncompaction of the myocardium in a patient with acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Emanuel Correia

    2010-05-01

    Full Text Available Miocárdio não compactado (MCNC é uma cardiopatia congênita rara, resultado da falha na compactação do miocárdio, levando à persistência de trabeculações numerosas e profundas, comunicantes com a cavidade ventricular. Tem como principais manifestações clínicas: insuficiência cardíaca, eventos arrítmicos (supraventriculares ou ventriculares e episódios de embolismo arterial. Apresenta-se o caso de um cidadão brasileiro residente em Portugal internado por infarto agudo do miocárdio, do qual resultou disfunção sistólica severa do ventrículo esquerdo. No decorrer do estudo diagnosticou-se MCNC. Descreve-se a apresentação clínica, ecocardiográfica (bidimensional e tridimensional, imagem de ressonância magnética nuclear (RMN e ventriculografia. Discutem-se os critérios diagnósticos e opções terapêuticas.El miocardio no compactado (MCNC es una cardiopatía congénita rara, resultado de la falla en la compactación del miocardio, y ocasiona la persistencia de trabeculaciones numerosas y profundas, comunicantes con la cavidad ventricular. Tiene como principales manifestaciones clínicas: insuficiencia cardiaca, eventos arrítmicos (supraventriculares o ventriculares y episodios de embolismo arterial.Left-ventricular non-compaction (LVNC is a rare congenital cardiopathy, which results from the failure of the myocardial compaction process, leading to the persistence of numerous and deep trabeculations communicating with the ventricular cavity. Its main clinical manifestations are heart failure, arrhythmias (supraventricular or ventricular and episodes of arterial embolism. The present case reports on a Brazilian patient living in Portugal, who was hospitalized due to acute myocardial infarction, which resulted in severe LV systolic dysfunction. During the patient's assessment, LVNC was diagnosed. The clinical presentation is described, as well as the echocardiographic evaluation (two-dimensional and three

  6. Edema agudo hemorrágico da infância: relato de três casos Acute hemorrhagic edema of infancy: report of three cases

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    Paulo Sergio Emerich

    2011-12-01

    Full Text Available O Edema Agudo Hemorrágico da Infância é uma vasculite leucocitoclástica pouco frequente, que ocorre, quase exclusivamente, em crianças entre 4 meses e 2 anos de idade. Caracteriza-se, clinicamente, pela tríade febre, lesões purpúricas na face, pavilhões auriculares e extremidades e edema. Embora os achados cutâneos sejam dramáticos e de surgimento rápido, o prognóstico é favorável, com resolução espontânea dentro de 1 a 3 semanas. Descrevem-se três casos cujos achados clínicos e histopatológicos são característicos de edema agudo hemorrágico da infância.Acute Hemorrhagic Edema of Infancy is an infrequent leukocytoclastic vasculitis which occurs almost exclusively in children between 4 months and 2 years of age. It is clinically characterized by the triad fever, purpuric lesions on the face, auricular pinna and extremities, and edema. Although the cutaneous findings are dramatic and of rapid onset, the prognosis is favorable, with spontaneous resolution within 1 to 3 weeks. Three cases are described in which clinical and histopathological findings are characteristic of acute hemorrhagic edema of infancy.

  7. Efectividad del modelo de cuidado de enfermería para la familia de paciente con infarto agudo al miocardio en la unidad de cuidados intensivos

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    David Jahel Garcia Avendaño

    2015-05-01

    Full Text Available Introducción: Este protocolo de investigación tiene la finalidad de intervenir con la familia y determinar la efectividad del Modelo de Cuidado de Enfermería para la Familia de Paciente con Infarto Agudo al Miocardio (IAM en la Unidad de Cuidados Intensivos (UCI. Materiales y Métodos: Estudio descriptivo de intervención familiar. Resultados y Discusión: El 100% de las familias respondió afirmativamente que la enfermera familiar les informo sobre los cuidados a realizar en la familia según las necesidades detectadas, estableció un plan de intervención en la familia mismo que cumplió y se interesó para que dentro de lo posible la estancia en la familia sea agradable. Conclusiones: Los resultados de esta investigación de intervención a las familias de paciente con IAM en las UCI aporta resultados que apoyan la importancia de aplicar un Modelo de Cuidado de Enfermería Familiar en dichas unidades.Cómo citar este artículo: García DJ, Estrada MC, Gallegos M, Antuna AB. Efectividad del modelo de cuidado de enfermería para la familia de paciente con infarto agudo al miocardio en la unidad de cuidados intensivos. Rev Cuid. 2015; 6(1: 923-31. http://dx.doi.org/10.15649/cuidarte.v6i1.166

  8. Investigación de vectores y reservorios en brote de Chagas agudo por posible transmisión oral en Aguachica, Cesar, Colombia

    Directory of Open Access Journals (Sweden)

    Hugo Soto

    2014-04-01

    Full Text Available Colombia tiene un registro de 11 casos de Chagas agudo y 80 casos por contaminación oral con Trypanosoma cruzi. Este trabajo analiza los hallazgos entomológicos y parasitológicos del brote de Aguachica, Cesar, en 2010. Un grupo interdisciplinario de profesionales de la salud y de universidades regionales realizó las pruebas de laboratorio a los pacientes y el estudio del foco de transmisión. Se detectaron 11 casos agudos de enfermedad de Chagas en una sola familia con vivienda sin triatominos domiciliados y, Rhodnius pallescens, Pantrongylus geniculatus, Eratyrus cuspidatus y dos Didelphis marsupialis infectados con T. cruzi en palmas de Attalea butyracea y Elaeis oleifera del área urbana de Aguachica. Se analiza la participación del R. pallescens y el rol de las palmas en el ciclo silvestre de T. cruzi y para la transmisión oral de la enfermedad de Chagas. Incursiones esporádicas de R. pallescens, P. geniculatus y E. cuspidatus silvestres desde palmas cercanas al domicilio humano pueden provocar brotes cada vez más frecuentes de Chagas oral.

  9. Research in cardiovascular care

    DEFF Research Database (Denmark)

    Jaarsma, Tiny; Deaton, Christi; Fitzsimmons, Donna

    2014-01-01

    with the increasing opportunities and challenges in multidisciplinary research, the Science Committee of the Council on Cardiovascular Nursing and Allied Professionals (CCNAP) recognised the need for a position statement to guide researchers, policymakers and funding bodies to contribute to the advancement...... of the body of knowledge that is needed to further improve cardiovascular care. In this paper, knowledge gaps in current research related to cardiovascular patient care are identified, upcoming challenges are explored and recommendations for future research are given....

  10. Morbilidad y mortalidad de los pacientes con síndrome de distress respiratorio agudo/injuria pulmonar aguda por Influenza A H1N1 que requirieron soporte cardiopulmonar en un hospital general

    Directory of Open Access Journals (Sweden)

    Jaime Zegarra

    2012-03-01

    Full Text Available Objetivo: Determinar la morbilidad y mortalidad de los pacientes con síndrome de distress respiratorio agudo (SDRA/injuria pulmonar aguda (IPA por Influenza A H1N1 que requirieron soporte cardiopulmonar en un hospital general. Material y métodos: Estudio retrospectivo, descriptivo, tipo serie de casos. Se revisaron las historias clínicas, las hojas de monitoreo ventilatorio y hemodinámico de los pacientes con SDRA/IPA secundario a Influenza A H1N1 atendidos en el Servicio de Cuidados Intensivos Generales (SCIG del Hospital Nacional Cayetano Heredia entre mayo y setiembre de 2009. El diagnóstico de Influenza A H1N1 se realizó por PCR-RT. Resultados: Se atendieron 99 pacientes con Influenza A H1N1, 9 ingresaron al SCIG por SDRA/IPA; cinco requirieron ventilación mecánica invasiva (VMI, tres ventilación mecánica no invasiva y uno no requirió soporte ventilatorio. La edad promedio fue 43,3 ± 18,3 años; el tiempo de enfermedad 8 ± 3 días. Al ingreso, el 100% tuvo fiebre y disnea, el score APACHE II fue 10,5 ± 4,1 y el SOFA 5,6 ± 3,2; el Pa02/Fi02 96,74 ± 28,6. En 4/5 pacientes en VMI el Pa02/Fi02 a las 12 h y al final de la ventilación mecánica fue < 200. La presión en cuña estimada fue 15,69 ± 3,6 y el índice cardiaco por doppler esofágico 2,4 ± 0,34. La TGO fue 160 ± 152,15, DHL 2366,33 ± 1862,13 y CPK 216 ± 298,25. Todos los pacientes recibieron Oseltamivir 150 mg cada 12 h por 10 días. Cuatro pacientes fallecieron. Conclusiones: Los pacientes con SDRA/IPA por Influenza A H1 N1, fueron adultos jóvenes, con tiempo de enfermedad prolongado; con fiebre, disnea y linfopenia; sin compromiso cardiovascular y con hipoxemia refractaria como causa de muerte.

  11. Obesidad e indicadores antropométricos en una muestra de varones con Síndrome Coronario Agudo, en un Área de Salud que incluye reclusos: estudio caso-control

    Directory of Open Access Journals (Sweden)

    A. Martín-Castellanos

    2015-06-01

    Full Text Available Objetivos: la obesidad es un factor de riesgo cardiovascular con alta prevalencia, y relacionado con la cardiopatia isquemica. El objetivo fue analizar mediante antropometria, una muestra de varones con Síndrome Coronario Agudo (SCA diagnosticado en un hospital de referencia penitenciaria, y un grupo control. Material y método: estudio caso-control en un Área de Salud que integraba a un Centro Penitenciario. Los participantes fueron 204 varones, 102 infartados y un control por cada caso. Se midió peso, talla, cintura minima (CC, cintura umbilical (CU y cadera. Se calcularon el IMC y otros indicadores. Se realizo un análisis descriptivo y se obtuvieron las áreas bajo la curva (ABC "receiver operating characteristich", las odds ratio (OR, y las correlaciones en SCA. Resultados: la obesidad presentó mayor prevalencia en SCA (31,4% vs 9,1%; OR: 4,7, otros indicadores mostraron asociación discriminatoria: IMC (ABC: 0,699; OR: 3,9, CC (ABC: 0,750; OR: 6,3, CU (ABC: 0,777; OR: 10, talla inversa (ABC: 0,619; OR: 2,1, índice cintura/cadera (ABC: 0,832; OR: 11,6; índice CU/cadera (ABC: 0,857; OR: 15,6, índice CU/talla (ABC: 0,800; OR: 8,9. Las correlaciones entre las cinturas y los índices cintura-talla fueron fuertes (todas r >0,90; p <0,001. Discusión: los indicadores antropométricos de obesidad están asociados al SCA. La CU es la medida simple más asociada. El IMC presenta una asociación débil; el índice CU/talla presenta alto poder discriminatorio y la mejor correlación antropométrica de riesgo, apoyando su uso en la identificación de varones con riesgo de infarto de miocardio tanto en la población general como penitenciaria.

  12. Calidad de la atención médica a pacientes con infarto agudo del miocardio. Cienfuegos 2011

    Directory of Open Access Journals (Sweden)

    Hilda María Delgado Acosta

    2013-09-01

    Full Text Available Fundamento: la evaluación constituye una herramienta para mejorar la calidad de la atención a los pacientes. Objetivo: evaluar la calidad de la atención médica a pacientes con infarto agudo de miocardio admitidos en el Hospital General Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos en junio de 2011. Métodos: se realizó una investigación de sistemas y servicios de salud en la que se analizaron como variables: las relacionadas con estructura (recursos humanos y materiales, procesos (cumplimiento de los protocolos establecidos para la atención y resultados (impacto en la mortalidad. Se aplicó un formulario a los 22 pacientes estudiados, se utilizó una guía de observación que evaluó la existencia de recursos humanos y materiales necesarios para la atención en el hospital. Los datos se procesaron en el programa SPSS 15,0 y se expresaron en números absolutos y porcientos. Resultados: en la dimensión estructura no se encontraron carencias de recursos materiales esenciales para la atención, hubo dificultades con la cobertura de enfermería en el Servicio de Cardiología. En la atención prehospitalaria hubo demora en acudir a consulta, dificultades en la prescripción de aspirina y la no realización de trombólisis. En la posthospitalaria se centraron en la rehabilitación y trabajo en la modificación de los factores de riesgo asociados. En el hospital hubo dificultades en la realización de las pruebas ergométricas al alta y en la remisión para la rehabilitación en el Área de Salud. Conclusiones: existen dificultades en la calidad de atención a los pacientes, dificultades que se hacen más evidentes en la Atención Primaria de Salud.

  13. 123. Intervención quirúrgica urgente en paciente varón joven con angiosarcoma primario cardíaco con diagnóstico de tromboembolismo pulmonar agudo

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    N. Miranda

    2012-04-01

    Conclusiones: Son infrecuentes los casos de sarcoma cardíaco primario publicados en la bibliografía y muy pocos los que han cursado como tromboembolismo pulmonar agudo. Este caso ilustra la enorme dificultad que presentan para un diagnóstico y tratamiento precoz que ofrezca unas mínimas expectativas de vida a medio plazo.

  14. Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

    Directory of Open Access Journals (Sweden)

    Fernando Rosso

    2016-08-01

    Conclusión. La infección por dengue fue frecuente en adultos mayores como causa de síndrome febril agudo. Una importante proporción requirió hospitalización y presentó complicaciones, sin embargo, el manejo adecuado evitó los casos fatales.

  15. Postirradiation cardiovascular dysfunction

    International Nuclear Information System (INIS)

    Hawkins, R.N.; Cockerham, L.G.

    1987-01-01

    Cardiovascular dysfunction may be defined as the inability of any element of the cardiovascular system to perform adequately upon demand, leading to inadequate performance and nutritive insufficiency of various parts of the body. Exposure to supralethal doses of radiation (accidental and therapeutic) has been show to induce significant alterations in cardiovascular function in man. These findings indicate that, after irradiation, cardiovascular function is a major determinant of continued performance and even survival. For the two persons who received massive radiation doses (45 and 88 Gy, respectively) in criticality accidents, the inability to maintain systematic arterial blood pressure (AP) was the immediate cause of death. In a study of cancer patients given partial-body irradiation, two acute lethalities were attributed to myocardial infarction after an acute hypotensive episode during the first few hours postexposure. Although radiation-induced cardiovascular dysfunction has been observed in many species, its severity, duration, and even etiology may vary with the species, level of exposure, and dose rate. For this reason, our consideration of the effects of radiation on cardiovascular performance is limited to the circulatory derangements that occur in rat, dog, and monkey after supralethal doses and lead to radiation-induced cardiovascular dysfunction in these experimental models. The authors consider other recent data as they pertain to the etiology of cardiovascular dysfunction in irradiated animals

  16. Lifestyle in Cardiovascular Disease

    NARCIS (Netherlands)

    J.O. Younge (John)

    2015-01-01

    markdownabstract__Abstract__ Globally, the burden of cardiovascular disease (CVD) is still increasing. However, in recent decades, better treatment modalities have led to less cardiovascular related deaths. After years of research, we now generally accept that lifestyle factors are the most

  17. Caracterización de los micrornas implicados en el infarto agudo de miocardio sometido a angioplastia primaria

    OpenAIRE

    Guisado Rasco, Agustín

    2016-01-01

    Falta palabras clave En nuestro país, las enfermedades cardiovasculares constituyen uno de los problemas de salud más importantes para la población. Las enfermedades cardiovasculares constituyen la primera causa de muerte para el conjunto de la población española. La mayoría de las muertes evitables se deben a enfermedades coronarias, y se producen en el medio extrahospitalario. Durante el año 2007 la enfermedad isquémica del corazón produjo 37.222 muertes, lo que supone un 9,65% de todas ...

  18. Triglycerides and cardiovascular disease

    DEFF Research Database (Denmark)

    Nordestgaard, Børge G; Varbo, Anette

    2014-01-01

    cholesterol might not cause cardiovascular disease as originally thought has now generated renewed interest in raised concentrations of triglycerides. This renewed interest has also been driven by epidemiological and genetic evidence supporting raised triglycerides, remnant cholesterol, or triglyceride......-rich lipoproteins as an additional cause of cardiovascular disease and all-cause mortality. Triglycerides can be measured in the non-fasting or fasting states, with concentrations of 2-10 mmol/L conferring increased risk of cardiovascular disease, and concentrations greater than 10 mmol/L conferring increased risk...... of acute pancreatitis and possibly cardiovascular disease. Although randomised trials showing cardiovascular benefit of triglyceride reduction are scarce, new triglyceride-lowering drugs are being developed, and large-scale trials have been initiated that will hopefully provide conclusive evidence...

  19. Validez del cuestionario cardiovascular MONICA comparado con la historia clínica Validity of the MONICA cardiovascular questionnaire compared with clinical records

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    José M. Baena-Díez

    2009-12-01

    Full Text Available Objetivo: Estudiar la validez del cuestionario cardiovascular Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA comparado con la historia clínica. Métodos: Estudio descriptivo, prospectivo, multicéntrico, realizado en 3.329 personas >50 años de edad (estudio ARTPER [arteriografía periférica]. La muestra se seleccionó por muestreo aleatorio simple en 32 centros de salud de atención primaria. Los diagnósticos considerados fueron: infarto agudo de miocardio, ángor, enfermedad vascular cerebral, hipertensión arterial, diabetes mellitus e hipercolesterolemia. Se estudió además el tratamiento con antihipertensivos, hipolipemiantes o insulina, hipoglucemiantes y antiagregantes o anticoagulantes. La validez entre cuestionario y registro en la historia clínica se estudió con la sensibilidad, la especificidad, los valores predictivos y el índice kappa. Resultados: La edad media fue de 65 años (desviación estándar: 8,9, y el 54,8% eran mujeres. La sensibilidad del cuestionario fue >90% en todas las variables, excepto en el ángor (89,9% y la enfermedad vascular cerebral (86,5%. La especificidad también fue >90%, excepto en el ángor (88,3% y la hipercolesterolemia (77,5%. El valor predictivo positivo fue >90% en todos los tratamientos farmacológicos; >80% en el ángor, el infarto agudo de miocardio y la hipertensión arterial; 79,4% en la enfermedad vascular cerebral; 79,1% en la hipercolesterolemia, y 73,4% en la diabetes mellitus. Los valores predictivos negativos fueron >90% en todos los casos. Los índices kappa fueron >0,80 en todas las variables, excepto en la hipercolesterolemia (0,69 y la diabetes mellitus (0,79. Conclusiones: El cuestionario cardiovascular MONICA es un método válido para encuestar a las personas >50 años sobre sus enfermedades, factores de riesgo y tratamientos cardiovasculares.Objective: To assess the validity of the questionnaire Multinational Monitoring of Trends and

  20. Características clínico epidemiológicas de pacientes con infarto miocárdico agudo

    Directory of Open Access Journals (Sweden)

    Omar Lóriga García

    2013-12-01

    Full Text Available Introducción: la cardiopatía isquémica, y entre estas el Infarto Agudo del Miocardio con elevación del segmento ST, es la primera causa de muerte a nivel mundial. Objetivo: describir las características clínico epidemiológicas de pacientes con infarto agudo del miocardio de la unidad de cuidados coronarios del Hospital General Docente Abel Santamaría Cuadrado de Pinar del Río, en 2011 y 2012. Material y Método: estudio observacional, descriptivo, retrospectivo transversal; universo 644 pacientes ingresados con elevación del ST. Los datos se tomaron de las historias clínicas. Resultados: 62% tenían entre 60- 79 años. 84.5% de los pacientes entre 30 y 49 años eran hombres. 81,6% fumaba y el 45,5% era diabético. La localización topográfica del infarto fue: inferior el 70,8%, anterior el 22,9% y anterior extensa el 6,2% de los pacientes. Como complicación, la arritmia se presentó en el 34% de los pacientes, la insuficiencia cardiaca en el 14,9% y la muerte en 7,7%. El 68,5% de los pacientes con arritmias tuvo fibrilación auricular. La trombolisis se empleó en el 55,2% de los pacientes apareciendo, entre las complicaciones, la hipotensión en el 30,7%. Conclusiones: el infarto miocárdico agudo fue más frecuente en pacientes de mayor edad, siendo antes de los 50 años cinco veces más frecuente entre los hombres. Los factores de riesgo más representados fueron el hábito de fumar y la diabetes mellitus. La localización más frecuente fue la inferior y la complicación las arritmias y dentro de estas la fibrilación auricular. La trombolisis se complica principalmente con hipotensión, pudiendo ser más empleada.

  1. Perfil etiológico del síndrome febril icterohemorrágico agudo y síndrome febril ictérico agudo en los valles del Apurímac, Quillabamba, Chanchamayo y Alto Huallaga, Perú, 1999-2000.

    Directory of Open Access Journals (Sweden)

    2003-07-01

    Full Text Available Objetivos: Conocer el perfil etiológico del síndrome febril hemorrágico agudo (SFHA y del síndrome febril ictérico agudo (SFIA en los valles del Río Apurímac (Ayacucho, Quillabamba (Cusco, Chanchamayo (Junín y Alto Huallaga (Huánuco. Materiales y métodos: Estudio longitudinal descriptivo realizado entre junio de 1999 y mayo de 2000, en 146 establecimientos de salud de los cuatro valles involucrados. Fueron incluidos pacientes que cumplieron con las definiciones de caso para la vigilancia del síndrome febril hemorrágico agudo y el síndrome febril ictérico agudo. Las muestras obtenidas se procesaron por ELISA IgM de captura para fiebre amarilla; IgM anti-HBc ELISA y HBsAg ELISA para hepatitis B; Ig anti-VHD ELISA para hepatitis D; e IgM ELISA para leptospirosis. Resultados: Fueron incluidos 63 casos: 98,4% con SFIA y 1,6% con SFHA. La letalidad fue de 16% y el tiempo entre inicio de síntomas y la obtención de la muestra de 7,2 ±5,1 días. Los casos que tuvieron confirmación diagnóstica fueron 31 (49,2%, hepatitis B (23,8%, hepatitis D (15,6%, fiebre amarilla (4,8% y leptospirosis (4,8%. Cusco tuvo el mayor porcentaje de casos confirmados por laboratorio, siendo la mayoría hepatitis B y D. Conclusiones: El estudio de la etiología de SFIA y SFHA ha permitido identificar tres brotes de fiebre amarilla en Cusco, Junín y Huánuco, y conocer la importancia de la hepatitis B, D y leptospirosis en el diagnóstico diferencial de estos síndromes. Si bien las definiciones usadas apuntan a detectar enfermedades severas, la vigilancia de ambos síndromes es complementaria y totalmente compatible con los sistemas de enfermedad específica y por el laboratorio.

  2. Caffeine and cardiovascular health.

    Science.gov (United States)

    Turnbull, Duncan; Rodricks, Joseph V; Mariano, Gregory F; Chowdhury, Farah

    2017-10-01

    This report evaluates the scientific literature on caffeine with respect to potential cardiovascular outcomes, specifically relative risks of total cardiovascular disease (CVD), coronary heart disease (CHD) and acute myocardial infarction (AMI), effects on arrhythmia, heart failure, sudden cardiac arrest, stroke, blood pressure, hypertension, and other biomarkers of effect, including heart rate, cerebral blood flow, cardiac output, plasma homocysteine levels, serum cholesterol levels, electrocardiogram (EKG) parameters, heart rate variability, endothelial/platelet function and plasma/urine catecholamine levels. Caffeine intake has been associated with a range of reversible and transient physiological effects broadly and cardiovascular effects specifically. This report attempts to understand where the delineations exist in caffeine intake and corresponding cardiovascular effects among various subpopulations. The available literature suggests that cardiovascular effects experienced by caffeine consumers at levels up to 600 mg/day are in most cases mild, transient, and reversible, with no lasting adverse effect. The point at which caffeine intake may cause harm to the cardiovascular system is not readily identifiable in part because data on the effects of daily intakes greater than 600 mg is limited. However, the evidence considered within this review suggests that typical moderate caffeine intake is not associated with increased risks of total cardiovascular disease; arrhythmia; heart failure; blood pressure changes among regular coffee drinkers; or hypertension in baseline populations. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  3. LA INFLAMACIÓN COMO FACTOR CAUSAL EMERGENTE DE LA ENFERMEDAD CARDIOVASCULAR

    Directory of Open Access Journals (Sweden)

    T. Fernández-Mora

    2007-06-01

    Full Text Available La ateroesclerosis está involucrada en el desarrollo de la enfermedad cardiovascular, una de las principales enfermedades de morbimortalidad en el mundo. Se han determinado una serie de factores de riesgo, tanto clásicos como emergentes, implicados en el desarrollo de esta enfermedad. Recientes investigaciones han demostrado que la inflamación juega un papel clave en el desarrollo de la ateroesclerosis. Las células del sistema inmune se encuentran presentes en todos los estadios de las lesiones arterioescleróticasy sus moléculas efectoras pueden acelerar la progresión de las lesiones y orquestar los mecanismos de inflamación inducidos en los síndromes coronarios agudos. La evidencia crítica implica a mediadores de la inmunidad tanto innata como adquirida en los diferentes estados de la ateroesclerosis. Dentro de loscomponentes inmunes involucrados en el proceso de la ateroesclerosis se encuentran componentes celulares como macrófagos, linfocitos, células dendríticas, mastocitos, células NK; componentes humoralescomo anticuerpos, citocinas proinflamatorias y moduladoras de la respuesta inmune, complemento, proteínas de fase aguda; y otros componentes como moléculas de adhesión y de choque térmico. A partirdel esclarecimiento del papel del sistema inmune en el desarrollo de la arterioesclerosis, han surgido una serie de perspectivas diagnósticas y terapéuticas para la enfermedad cardiovascular.

  4. Cardiovascular involvement in myositis

    DEFF Research Database (Denmark)

    Diederichsen, Louise P

    2017-01-01

    PURPOSE OF REVIEW: The purpose of this review is to provide an update on cardiovascular involvement in idiopathic inflammatory myopathy (IIM). Studies from the past 18 months are identified and reviewed. Finally, the clinical impact of these findings is discussed. RECENT FINDINGS: Epidemiological...... on cardiac magnetic resonance (CMR) imaging suggests that CMR should be considered as a potentially viable diagnostic tool to evaluate the possibility of silent myocardial inflammation in IIM with normal routine noninvasive evaluation. SUMMARY: Updated literature on cardiovascular involvement in IIM has...... identified an increased risk for subclinical and clinical cardiovascular disease in these rare inflammatory muscle diseases....

  5. Cardiovascular complications of cirrhosis

    DEFF Research Database (Denmark)

    Møller, S; Henriksen, Jens Henrik Sahl

    2008-01-01

    Cardiovascular complications of cirrhosis include cardiac dysfunction and abnormalities in the central, splanchnic and peripheral circulation, and haemodynamic changes caused by humoral and nervous dysregulation. Cirrhotic cardiomyopathy implies systolic and diastolic dysfunction and electrophysi......Cardiovascular complications of cirrhosis include cardiac dysfunction and abnormalities in the central, splanchnic and peripheral circulation, and haemodynamic changes caused by humoral and nervous dysregulation. Cirrhotic cardiomyopathy implies systolic and diastolic dysfunction....... The clinical significance of cardiovascular complications and cirrhotic cardiomyopathy is an important topic for future research, and the initiation of new randomised studies of potential treatments for these complications is needed....

  6. Crowdfunding for cardiovascular research.

    Science.gov (United States)

    Krittanawong, Chayakrit; Zhang, HongJu Janet; Aydar, Mehmet; Wang, Zhen; Sun, Tao

    2018-01-01

    The competition for public cardiovascular research grants has recently increased. Independent researchers are facing increasing competition for public research grant support and ultimately may need to seek alternative funding sources. Crowdfunding, a financing method of raising funds online by pooling together small donations from the online community to support a specific initiative, seems to have significant potential. However, the feasibility of crowdfunding for cardiovascular research remains unknown. Here, we performed exploratory data analysis of the feasibility of online crowdfunding in cardiovascular research. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Molecular cardiovascular imaging

    International Nuclear Information System (INIS)

    Schaefers, M.

    2007-01-01

    Although huge and long-lasting research efforts have been spent on the development of new diagnostic techniques investigating cardiovascular diseases, still fundamental challenges exist; the main challenge being the diagnosis of a suspected or known coronary artery disease or its consequences (myocardial infarction, heart failure etc.). Beside morphological techniques, functional imaging modalities are available in clinical diagnostic algorithms, whereas molecular cardiovascular imaging techniques are still under development. This review summarizes clinical-diagnostical challenges of modern cardiovascular medicine as well as the potential of new molecular imaging techniques to face these. (orig.)

  8. Hematoma subdural agudo traumático: estudo de 110 pacientes Acute traumatic subdural haematomas: study of 110 cases

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    Nicandro de Figueiredo Neto

    1996-06-01

    Full Text Available Apresentamos uma série consecutiva de 110 pacientes com hematoma subdural agudo traumático (HSDA admitidos no serviço de emergência do HBDF no período de 1°-janeiro a 1°-dezembro-1994. Todos os pacientes foram atendidos de acordo com o mesmo protocolo. Houve predominância do sexo masculino (79%, com idade variando entre 14 e 70 anos, sendo os atropelamentos (34% e os acidentes automobilísticos (20% as causas mais comuns. A maioria dos pacientes (85,7% foi admitida muito grave, com 8 pontos ou menos na Escala de Coma Glasgow (ECG, o que influenciou diretamente na mortalidade. A tomografia computadorizada de crânio foi o exame diagnóstico de escolha que mostrou serem as contusões e o inchaço cerebral ("swelling" as lesões intracranianas associadas mais freqüentes. A cirurgia foi realizada em 45,1% dos pacientes, e, em sua maioria, através de craniotomia fronto-têmporo-parietal ampla, com drenagem do hematoma, seguida de plástica da dura-mater. Em 54,9% as condições clínicas não permitiram a realização da cirurgia; neste grupo, cerca de 69,6% estavam em coma profundo à admissão, com 3 pontos na ECG. A letalidade cirúrgica foi de 61,2% e esteve diretamente relacionada à condição clínica inicial e à idade do paciente. A letalidade, incluindo todos os pacientes cirúrgicos e não cirúrgicos com HSDA, mesmo aqueles admitidos já com sinais de falência de tronco cerebral, foi de 79,5%. Além destes pacientes que faleceram, cerca de 7% evoluíram sem seqüelas ou com seqüelas mínimas; outros 11,4% com seqüelas de moderadas a paves e 2,1 % permaneceram em estado vegetativo persistente. Nossos dados estão de acordo com os da literatura no que se refere a elevada taxa de morbidade e mortalidade dos pacientes com HSDA.We report a series of 110 patients with acute traumatic subdural hematoma (ASDH admitted at HBDF emergency within 1994 (January Is1 to December PJ.All patients were treated according to the same protocol

  9. Años de vida perdidos por infarto agudo de miocardio en la Argentina entre 1991 y 2005

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    Fernando Botto

    2008-01-01

    Full Text Available IntroducciónLos años potenciales de vida perdidos (APVP son uno de los indicadores utilizados para determinar las muertes tempranas. A diferencia de las tasas de mortalidad, crudas y ajustadas por edad, este indicador, que cuantifica los años que teóricamente una persona deja de vivir si la muerte se presenta en forma prematura (o sea antes de cumplir su esperanza de vida, da una visión más amplia de la importancia relativa que tienen las causas más relevantes de mortalidad prematura, por lo que su uso se justifica en la planificación y en la definición de prioridades en salud.ObjetivosDescribir la evolución de la mortalidad por infarto agudo de miocardio (IAM en términos de tasas de mortalidad (TM y de años potenciales de vida perdidos (APVP para el período 1991-2005, identificar diferencias en relación con el sexo y comparar la media de APVP por muerto (MAPVP entre los registros SAC y los de la Dirección de Estadística e Información de Salud del Ministerio de Salud y Acción Social (DEIS.Material y métodosLas defunciones por IAM, distribuidas por edad y sexo, se obtuvieron de la DEIS y de los registros SAC. Los APVP se calcularon según la fórmula de Romeder y Mc Whinnie y también sobre la base de la esperanza de vida al nacer, además de la MAPVP con su intervalo de confianza del 95%.ResultadosLa TM por IAM según la DEIS descendió de 50 en 1991 a 38 por 100.000 habitantes en 2005 (pendiente [slope] -3,7; p < 0,001. La tasa de APVP disminuyó de 516 a 314 años por 100.000 en igual período. A nivel nacional, la MAPVP fue de 11,3 (11,1-11,5, 11,4 (11,2- 11,6, 11,5 (11,3-11,7, 11,1 (10,8-11,3 para 1991, 1996, 2000 y 2005, respectivamente (pendiente 0,0. Se observaron resultados similares a los de la SAC -10,8 (8,22-13,5, 10,4 (6,86- 14,0, 7,50 (4,67-10,3, 14,0 (10,3-17,7- para los años mencionados (pendiente +0,67. En relación con el sexo tampoco hubo diferencias, excepto para el caso de las mujeres en el año 2000 (p

  10. Uso de alteplase no tratamento do acidente vascular encefálico isquêmico agudo: o que sabem os enfermeiros?

    Directory of Open Access Journals (Sweden)

    Samia Jardelle Costa de Freitas Maniva

    2012-06-01

    Full Text Available O estudo objetivou analisar o conhecimento de enfermeiros acerca do uso de alteplase no tratamento do acidente vascular encefálico (AVE isquêmico agudo. Estudo descritivo-exploratório realizado em uma unidade de AVE de um hospital público localizado na cidade de Fortaleza-CE, durante o mês de outubro de 2010. Participaram do estudo dez enfermeiros, com idade média de 25 anos. Os benefícios da medicação foram apresentados em justaposição com as limitações do uso. Estratégias para ampliar a utilização de alteplase foram apontadas pelos enfermeiros. O conhecimento da realidade investigada contribui na construção do saber de enfermagem e pode auxiliar o enfermeiro que presta assistência direta ao paciente que se submete a este tratamento.

  11. Edema agudo hemorrágico da infância: relato de três casos Acute hemorrhagic edema of infancy: report of three cases

    OpenAIRE

    Paulo Sergio Emerich; Patricia Almeida Prebianchi; Luciene Lage da Motta; Elton Almeida Lucas; Leonardo Mello Ferreira

    2011-01-01

    O Edema Agudo Hemorrágico da Infância é uma vasculite leucocitoclástica pouco frequente, que ocorre, quase exclusivamente, em crianças entre 4 meses e 2 anos de idade. Caracteriza-se, clinicamente, pela tríade febre, lesões purpúricas na face, pavilhões auriculares e extremidades e edema. Embora os achados cutâneos sejam dramáticos e de surgimento rápido, o prognóstico é favorável, com resolução espontânea dentro de 1 a 3 semanas. Descrevem-se três casos cujos achados clínicos e histopatológi...

  12. CARACTERIZACIÓN DEL SÍNDROME CORONARIO AGUDO SIN ELEVACIÓN DEL ST EN EL CENTRO DIAGNÓSTICO INTEGRAL

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    Rider Piñeiro López

    2012-03-01

    Full Text Available Resumen Introducción y objetivos: El síndrome coronario agudo presenta una elevada incidencia en el cuadro de morbilidad y mortalidad de los países del mundo desarrollado. El objetivo de esta investigación fue determinar la morbilidad por síndrome coronario agudo y su relación con algunas variables. Método: Se realizó un estudio epidemiológico, observacional, descriptivo, en 30 pacientes con el diagnóstico de síndrome coronario agudo sin elevación del ST, atendidos en la Unidad de Terapia Intensiva del Centro Diagnóstico Integral “José Gregorio Hernández”, municipio Ortiz, estado Guárico, República Bolivariana de Venezuela; en el período del 1 de enero al 31 de diciembre de 2007. Resultados: La angina inestable fue la enfermedad más frecuente (80,0 % en estos pacientes. Predominaron los mayores de 49 años (80 %, del sexo femenino (63,3 %, color negro de piel, procedencia urbana y escolaridad secundaria. El tabaquismo constituyó el factor de riesgo más frecuente (56,6 %, seguido de hipertensión arterial (43,3 % y obesidad (26,6 %. Las arritmias y el fallo de bomba fueron frecuentes en pacientes con infarto; el dolor precordial mantenido, en enfermos con angina inestable. Hubo un fallecido por infarto agudo de miocardio, con más de sesenta años y menos de tres días de estadía. Conclusiones: Predominó la angina inestable, y los factores de riesgo más frecuentemente asociados, fueron la hipertensión arterial y el hábito de fumar. Abstract Introduction and objectives: Acute coronary syndrome has a high impact on morbidity and mortality rates of the developed world. The objective of this research was to determine the morbidity for acute coronary syndrome and its relation to some variables. Method: An epidemiological, observational, descriptive study was performed in 30 patients with the diagnosis of acute coronary syndrome without ST elevation, treated at the Intensive Care Unit of the Integral Diagnostic Center "Jos

  13. Infarto agudo del miocardio en los centros diagnósticos integrales de Vargas, Venezuela Myocardial acute infarction in integral diagnosis centers of Vargas, Venezuela

    Directory of Open Access Journals (Sweden)

    Ana Rosa Jorna Calixto

    2010-12-01

    Full Text Available INTRODUCCIÓN: el infarto agudo del miocardio constituyó más del 12 % de los fallecimientos por cardiopatía isquémica en Venezuela en 2006, sin evidenciarse disminución en la mortalidad a pesar del mejoramiento tecnológico de los servicios de urgencias. OBJETIVO: caracterizar su comportamiento en los centros de diagnóstico integrales del Estado de Vargas, en el período comprendido de junio de 2006 a junio de 2009. MÉTODOS: se realizó un estudio descriptivo, retrospectivo para caracterizar el comportamiento del infarto agudo del miocardio en los servicios de urgencia y emergencia de los centros de diagnóstico integrales utilizando las estadísticas de la Misión Barrio Adentro. RESULTADOS: fueron atendidos 186 pacientes por infarto agudo del miocardio, predominaron los ingresos en la terapia intensiva (2,4 % sobre los servicios de hospitalización. Los fallecidos por esta causa fueron 35 personas, 17,1 % del total de fallecidos. Fueron trombolizados el 39,2 %, con el mayor número alcanzado en el 2008 con 51,2 %. La letalidad por infarto agudo del miocardio osciló entre tasas de 17,3 y 20 por cada 100 pacientes vistos. La tasa de mortalidad bruta fue de 9,58 x 100 000 habitantes. CONCLUSIONES: el número de casos atendidos por infarto tuvo un comportamiento ascendente de manera estable, representaron el 0,7 % del total de ingresos en estos centros, con predominio de los ingresos en la terapia intensiva sobre los servicios de hospitalización. Se le aplicó el tratamiento trombolítico con estreptoquinasa recombinante a un por ciento importante de enfermos. En los servicios de hospitalización fue superior la letalidad por esta causa. No disminuyó el riesgo de morir para los pacientes con esta enfermedad y la mortalidad general en el período estudiado fue de 35 pacientes para una tasa de 9,58 × 100 000 habitantes.INTRODUCTION: the acute myocardial infarction was over the 12 % of deceased from ischemic heart disease in Venezuela in

  14. Neumonía eosinofílica: presentación de dos casos, agudo y crónico

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    Oscar Pamo Reyna

    2007-01-01

    Full Text Available Se presenta dos casos de neumonía eosinofílica idiopática, uno crónico y otro agudo. En el caso clínico 1 se realizó una confirmación anatomopatológica de neumonía eosinofílica idiopática y en el caso clínico 2 se tuvo una neumonia eosinofílica aguda probable. Ambos presentaron tos, fiebre y disnea. El estudio radiográfico reveló lesiones alveolares bilaterales con tendencia a la consolidación. La marcada eosinofilia en sangre periférica fue un dato resaltante que facilitó el diagnóstico. Ambos casos tuvieron muy buena respuesta a la corticoterapia.(Rev Med Hered 2007;18:39-44.

  15. Correlación clínica, laparoscópica e histológica en el abdomen agudo

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    María Elena Trujillo Toledo

    1995-12-01

    Full Text Available Se presentan 132 pacientes con diagnóstico clínico de abdomen agudo durante 1991 a 1993, a quienes se les realizó laparoscopia de urgencia. Las afecciones más frecuentes en que se realizó laparoscopia fueron: apendicitis aguda y las enfermedades ginecológicas. La efectividad de la laparoscopia en relación con el resultado histológico fue del 97,1 %, y no coincidió en 3 pacientes con diagnóstico laparoscópico de apendicitis aguda, hematosalpinx derecho y peritonitis pélvica, sin especificar factor causal. En el 19,6 % la conclusión laparoscópica evitó una intervención quirúrgica

  16. Terapia farmacológica en la mujer y prevención cardiovascular

    Directory of Open Access Journals (Sweden)

    Nohora I. Rodríguez-Guerrero

    2018-01-01

    Full Text Available Resumen: La enfermedad cardíaca es la principal causa de mortalidad en mujeres y dentro de estas sobresale la enfermedad coronaria. En las mujeres se posterga cerca de diez años el inicio de la enfermedad cardiovascular comparada con los hombres y la sintomatología así como las comorbilidades son diversas; en Colombia las enfermedades del aparato circulatorio representan la principal causa de mortalidad. Dentro de los factores de riesgo asociados a la enfermedad cardiovascular y con mayor frecuencia en las mujeres se reportaron la inactividad física, la obesidad, las dislipidemias, la hipertensión arterial, la diabetes mellitus y el tabaquismo. La particularidad de las enfermedades cardiovasculares en la mujer ha llevado a que se desarrollen guías específicas de prevención y tratamiento cardiovascular en la mujer, con recomendaciones relacionadas con los estilos de vida, farmacológicas y de intervenciones invasivas. Es claro que existen diferencias de género en cuanto a síntomas, abordaje terapéutico durante el evento coronario agudo y tratamiento en prevención primaria y secundaria y que momentos como la menopausia, marcan un punto de incremento del riesgo cardiovascular, con mayor prevalencia de varios de los factores de riesgo cardiovasculares. En general los medicamentos usados para el manejo de los factores de riesgo en las mujeres son similares a los indicados en la población masculina, sin encontrarse evidencia significativa de diferencias de dosis, beneficios adicionales o efectos colaterales con excepción de los IECA y los ARA2 en el embarazo, los antiagregantes plaquetarios en prevención primaria y la terapia trombolítica en algunos casos. Este artículo pretende describir las principales intervenciones farmacológicas de patologías cardiovasculares en las mujeres. Abstract: Heart disease is the main cause of mortality in women, with coronary disease being the main category. The onset of cardiovascular disease is

  17. El impacto de la reducción del estrés en la hipertensión esencial y las enfermedades cardiovasculares. (Impact of stress reduction on essential hypertension and cardiovascular disease.

    Directory of Open Access Journals (Sweden)

    David W. Orme-Johnson

    2008-07-01

    Full Text Available ResumenSe ha considerado que el estrés contribuye a la patogénesis y la progresión de las enfermedades cardiovasculares (ECV. Se ha demostrado que la reducción del estrés mediante la Meditación Trascendental [Transcendental Meditation (TM®] ha bajado los niveles de presión arterial (PA y reducido el riesgo de ECV en adultos y adolescentes. Este artículo repasa los resultados que sugieren el impacto beneficioso de la TM en reducir la PA en adultos hipertensos en reposo y en adolescentes pre-hipertensos en reposo, durante un estrés agudo creado en el laboratorio y durante la actividad diaria normal. Dichos resultados tienen implicaciones importantes para la inclusión de la TM en los esfuerzos que se realizan para prevenir y tratar las ECV y sus consecuencias clínicas.AbstractStress has been thought to contribute to the pathogenesis and progression of cardiovascular diseases (CVD. Stress reduction via Trasncendental Meditation (TM® has been shown to lower blood pressure (BP levels and reduce CVD risk in adults and adolescents. This article reviews findings suggesting a beneficial BP-lowering impact of TM in hypertensive adults at rest and in pre-hypertensive adolescents at rest, during acute laboratory stress and during normal daily activity. These findings have important implications for inclusion of TM efforts to prevent and treat cardiovascular diseases and their clinical consequences.

  18. Abdome agudo em pós-operatório tardio de apendicite aguda: pode não ser bridas

    Directory of Open Access Journals (Sweden)

    Bruno Castro Fernandes

    2014-10-01

    Full Text Available As ressecções intestinais em países desenvolvidos ocorrem devido às malformações congênitas. Em países em desenvolvimento essas resseções ocorrem por causas potencialmente evitáveis, como invaginação intestinal irredutível, trauma abdominal fechado, volvo de jejuno-íleo, enterocolite necrosante, hérnia inguinal estrangulada e obstrução por bridas pós-operatórias. O volvo intestinal na infância é raro e geralmente de causas iatrogênicas causado, por exemplo, pela presença de grampos soltos a cavidade intestinal após apendicectomia laparoscópica. O volvo de jejuno-íleo pode ser secundário à isquemia nos casos de gastrosquise tratadas com silo ou mesmo pela colocação de banda gástrica pós-laparoscopia, ou ainda pela presença de lipoma mesentérico. Não foi identificado trabalho na literatura recente sobre volvo jejuno-íleo e isquemia e necrose de segmento de alça intestinal. O autores relatam um caso de abdome agudo obstrutivo em criança de 6 anos, em pós-operatório tardio (4 anos de apendicectomia aberta e cuja ressecção de segmento de Alça intestinal foi necessária nas duas oportunidades mas por motivos diferentes. Situações adversas em abdome agudo pós-operatório podem não ser por aderências intestinais, mas por situações mais graves e o cirurgião deve estar preparado para corrigir sua tática operatória.

  19. Etiología del síndrome febril agudo en la provincia de Jaén, Perú 2004-2005

    Directory of Open Access Journals (Sweden)

    Lucinda Troyes R

    2006-01-01

    Full Text Available Objetivo: Conocer a tiología el Síndrome febril agudo en nacientes que acudieron a tres establecimientos de salud de la provincia de Jaén entre mayo de 2004 y abril de 2005. Materiales y métodos: Estudio descriptivo prospectivo realizado en tres establecimientos de salud: Hospital General de Jaén, Hospital de Apoyo Bellavista y Centro de Salud Morro Solar. Se incluyeron pacientes entre 5 y 65 años con fiebre de menos de ocho días de evolución y sin foco infeccioso aparente. Inicialmente se les realizó gota gruesa para malaria y frotis sanguíneo para Bartonelosis; de los casos negativos se obtuvo una segunda muestra de sangre para la búsqueda de ELISA IgM y microaglutinación para el diagnóstico de leptospirosis, ELISA IgM para dengue, Mayaro, Oropuche y encefalitis equina venezolana, e inmunofluorescencia indirecta para Rickettsiosis. Resultados: De 1039 febriles incluidos, se determinó la etiología en 680 (65,4%casos, malaria por P.falciparum 312 (30,0%, leptospirosis 115 (11,1%, dengue 105 (10,1%, malaria por P. vivax 76 (7,3%,leptospirosis más dengue 30 (2,9%, Rickettsiosis 15 (1,4%,Bartonelosis 17 (1,6%,leptospirosis más Rickettsiosis 7 (0,7%, y leptospirosis, dengue más Rickettsiosis 3 (0,3%. Los serovares de Leptospira más frecuentes fueron varilla (35,7%y bratislava (32,5%. Conclusión: La malaria es la principal causa de síndrome febril agudo en Jaén, se destaca la presencia de la leptospirosis como segunda causa,por delante del dengue; es necesario considerar dentro del diagnóstico diferencial Rickettsiosis y Bartonelosis.

  20. Estudo da síntese de pró-fármacos dendriméricos potencialmente cardiovasculares contendo rosuvastatina e ácido acetilsalicílico

    OpenAIRE

    Andressa Polidoro

    2013-01-01

    Doenças cardiovasculares podem ocasionar manifestações clínicas graves como infarto agudo do miocárdio e acidentes vasculares trombóticos, constituindo a principal causa de morte no mundo, fato esse que desperta grande interesse da indústria farmacêutica. As causas normalmente estão relacionadas à elevação dos níveis de colesterol e à agregação plaquetária, que acarretam eventos vaso-oclusivos. Entre as alternativas terapêuticas para o controle e prevenção das doenças cardiovasculares podem-s...

  1. Cardiovascular Disease in Acromegaly.

    Science.gov (United States)

    Sharma, Morali D; Nguyen, Anh V; Brown, Spandana; Robbins, Richard J

    2017-01-01

    In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications.

  2. Diagnósticos de enfermagem de pacientes hospitalizados com doenças cardiovasculares Diagnósticos de enfermería para pacientes hospitalizados com enfermedades cardiovasculares Nursing diagnoses for inpatients with cardiovascular diseases

    Directory of Open Access Journals (Sweden)

    Juliana de Melo Vellozo Pereira

    2011-12-01

    Full Text Available Objetivo: Identificar a frequência dos diagnósticos de enfermagem e características definidoras de pacientes com doenças cardiovasculares e caracterizá-los quanto às variáveis sociodemográficas e clínicas. Método: Estudo descritivo transversal realizado com 30 pacientes hospitalizados em um hospital de grande porte. Utilizou-se instrumento próprio validado para coleta de dados, que foram analisados por 5 peritos;, havendo concordância de 50%, sofreram análise estatística descritiva e inferencial. Resultados: Foram encontradas associações significativas com fatores Presença da Insuficiência Cardíaca, do Infarto Agudo do Miocárdio, da Dor, Sexo e Idade. Os diagnósticos mais frequentes foram: Ansiedade (76,7%, Dor Aguda (70,7%, Débito Cardíaco Diminuído (56,7%, Percepção Sensorial Perturbada - Visual (53,3%, Insônia (46,7%, Intolerância à Atividade (36,7%, Disfunção Sexual (36,7% e Eliminação Urinária Prejudicada (36,7%. Conclusão: a descrição dos diagnósticos de enfermagem contribui para a análise das respostas à doença cardiovascular, com foco no objeto de trabalho do enfermeiro, apresentando respostas à doença cardiovascular por meio de investigação holística.Objetivo: Identificar la frecuencia de los diagnósticos de enfermería y las características principales de los pacientes con enfermedades cardiovasculares y darles características cuanto a las variables sociodemográficas y clínicas. Método: Estudio descriptivo transversal realizado con 30 pacientes hospitalizados en un hospital de gran porte. Se utilizó instrumento propio validado para colecta de datos, estos fueron analizados por 5 peritos y, habiendo concordancia del 50%, sufrieron análisis estadística descriptiva e inferida. Resultados: fueron encontradas asociaciones significativas con los factores presencia de la insuficiencia cardíaca, del infarto agudo de miocardio, del dolor, sexo y edad. Los diagnósticos más frecuentes

  3. Envejecimiento del sistema cardiovascular Cardiovascular system aging

    Directory of Open Access Journals (Sweden)

    José M Ocampo

    2005-08-01

    Full Text Available El envejecimiento del sistema cardiovascular está asociado con un número característico de cambios a nivel bioquímico, histológico y morfológico. Sin embargo, no todas las modificaciones presentadas se asocian con deterioro en la función. Entre los cambios a nivel cardiaco se tienen: disminución en el número de miocitos y en las células del sistema de conducción cardiaca, desarrollo de fibrosis, cambios en el transporte de calcio a través de las membranas y disminución del cronotropismo, inotropismo y lusitropismo mediados por estímulo b-adrenérgico. A nivel vascular, hay incremento en la rigidez de la pared de las arterias, con aumento en la velocidad de la onda de pulso, disfunción endotelial y disminución de la vasodilatación mediada por estímulo b-adrenérgico. Durante el reposo el sistema cardiovascular es capaz de desarrollar mecanismos adaptativos eficientes, pero en situaciones de estrés como el ejercicio, los cambios asociados con el envejecimiento se hacen evidentes ya que está disminuida la capacidad para obtener la frecuencia cardiaca máxima, está incrementada la postcarga y hay disminución de la contractilidad intrínseca. Por lo anterior, los ancianos deben utilizar al máximo el mecanismo de Frank-Starling para mantener el gasto cardiaco. Los cambios estructurales y funcionales asociados con el envejecimiento cardiovascular, disminuyen de forma significativa el umbral en el cual las enfermedades cardiacas llegan a ser evidentes, y deben ser conocidos por el personal de salud encargado de cuidar a los ancianos.Cardiovascular aging is associated with characteristic biochemical, histological and morphological changes. Nevertheless, these changes are not necessarily associated to a deterioration in its function. Among the cardiac changes found, there is a reduction in the number of myocytes and of the cardiac conduction system cells, development of fibrosis, changes in the trans-membrane calcium transport and a

  4. Controvérsias acerca da acidose hipercápnica na síndrome do desconforto respiratório agudo Controversies involving hypercapnic acidosis in acute respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Liliane Nardelli

    2009-12-01

    Full Text Available A síndrome do desconforto respiratório agudo é caracterizada por uma reação inflamatória difusa do parênquima pulmonar induzida por um insulto direto ao epitélio alveolar (síndrome do desconforto respiratório agudo pulmonar ou indireto por meio do endotélio vascular (síndrome do desconforto respiratório agudo extrapulmonar. A principal estratégia terapêutica da síndrome do desconforto respiratório agudo é o suporte ventilatório. Entretanto, a ventilação mecânica pode agravar a lesão pulmonar. Nesse contexto, uma estratégia ventilatória protetora com baixo volume corrente foi proposta. Tal estratégia reduziu a taxa de mortalidade dos pacientes com síndrome do desconforto respiratório agudo, porém acarretou acidose hipercápnica. O presente artigo apresenta uma revisão da literatura acerca dos efeitos da acidose hipercápnica na síndrome do desconforto respiratório agudo. Para tal, realizou-se uma revisão sistemática da literatura científica conforme critérios já estabelecidos para análise documental incluindo artigos experimentais e clínicos sobre o tema, usando-se como bases de dados MedLine, LILACS, SciElo, PubMed, Cochrane. A acidose hipercápnica é defendida por alguns autores como moduladora do processo inflamatório da síndrome do desconforto respiratório agudo. Entretanto, estudos clínicos e experimentais acerca dos efeitos da acidose hipercápnica têm demonstrado resultados controversos. Logo, é fundamental a realização de mais pesquisas para elucidar o papel da acidose hipercápnica na síndrome do desconforto respiratório agudo.Acute respiratory distress syndrome is characterized by a diffuse inflammatory reaction of lung parenchyma induced by a direct insult to the alveolar epithelium (pulmonary acute respiratory distress syndrome or an indirect lesion through the vascular endothelium (extrapulmonary acute respiratory distress syndrome. The main therapeutic strategy for acute respiratory

  5. Diabetes Drugs and Cardiovascular Safety

    Directory of Open Access Journals (Sweden)

    Ji Cheol Bae

    2016-06-01

    Full Text Available Diabetes is a well-known risk factor of cardiovascular morbidity and mortality, and the beneficial effect of improved glycemic control on cardiovascular complications has been well established. However, the rosiglitazone experience aroused awareness of potential cardiovascular risk associated with diabetes drugs and prompted the U.S. Food and Drug Administration to issue new guidelines about cardiovascular risk. Through postmarketing cardiovascular safety trials, some drugs demonstrated cardiovascular benefits, while some antidiabetic drugs raised concern about a possible increased cardiovascular risk associated with drug use. With the development of new classes of drugs, treatment options became wider and the complexity of glycemic management in type 2 diabetes has increased. When choosing the appropriate treatment strategy for patients with type 2 diabetes at high cardiovascular risk, not only the glucose-lowering effects, but also overall benefits and risks for cardiovascular disease should be taken into consideration.

  6. Evaluación económica del stent medicado vs. convencional para pacientes con infarto agudo de miocardio con elevación del ST en Colombia

    Directory of Open Access Journals (Sweden)

    Mateo Ceballos

    2014-11-01

    Conclusiones: El stent medicado con sirolimus no es costo-efectivo para pacientes con infarto agudo de miocardio con elevación del ST en Colombia. Se recomienda mayor investigación futura sobre la probabilidad de muerte y trombosis muy tardía del stent, así como en subgrupos específicos de pacientes y stents medicados de segunda generación.

  7. Tea and Cardiovascular Disease

    Science.gov (United States)

    Deka, Apranta; Vita, Joseph A.

    2011-01-01

    There is increasing evidence for a protective effect of tea consumption against cardiovascular disease. This review summarizes the available epidemiological data providing evidence for and against such an effect. We also review observational and intervention studies that investigated an effect of tea and tea extracts on cardiovascular risk factors, including blood pressure, serum lipids, diabetes mellitus, and obesity. Finally, we review potential mechanisms of benefit, including anti-inflammatory, anti-oxidant, and anti-proliferative effects, as well as favorable effects on endothelial function. Overall, the observational data suggest a benefit, but results are mixed and likely confounded by lifestyle and background dietary factors. The weight of evidence indicates favorable effects on risk factors and a number of plausible mechanisms have been elucidated in experimental and translational human studies. Despite the growing body evidence, it remains uncertain whether tea consumption should be recommended to the general population or to patients as a strategy to reduce cardiovascular risk. PMID:21477653

  8. Entidades clínicas cardiovasculares asociadas al consumo de cocaína por vía nasal en una población peruana

    Directory of Open Access Journals (Sweden)

    Luis Razzeto-Ríos

    2008-06-01

    Full Text Available Objetivos: Conocer la frecuencia de entidades clínicas cardiovasculares asociadas al empleo de cocaína por vía nasal en consumidores peruanos. Diseño: Estudio prospectivo, descriptivo, tipo serie de casos. Lugar: Hospital Edgardo Rebagliati Martins, EsSalud, hospital docente, y Clínica San Felipe. Participantes: Pacientes atendidos entre los años 1991 y 2006. Principales medidas de resultados: Síntomas y entidades clínicas asociadas al consumo de cocaína vía nasal. Resultados: En los 63 pacientes evaluados, la mediana de edad fue 35 años, 53 (84% eran de sexo masculino, 86% afirmó haber ingerido cocaína previamente. Los síntomas aparecieron antes de las 2 horas en 78% de los pacientes y 81% presentó trastornos del electrocardiograma. Los síntomas reportados fueron dolor torácico (59%, palpitaciones (27%, convulsiones (5%, hipertermia (3% y cefalea (6%. Las entidades clínicas asociadas fueron: síndromes coronarios agudos (49%, arritmia ventricular (25%, infarto agudo de miocardio (10%, crisis hipertensiva (5% y muerte súbita (11%. Durante el seguimiento, la reincidencia en el consumo se produjo en 76%, siendo esta predominantemente en los primeros 6 meses (63%. Conclusiones: El empleo de cocaína intranasal se asocia a importantes entidades clínicas cardiovasculares, la mayoría de ellas graves. Se aconseja la evaluación de los pacientes en emergencia, incluyendo una anamnesis completa dirigida a la evaluación del consumo de sustancias ilícitas.

  9. Pharmacogenomics and cardiovascular disease

    DEFF Research Database (Denmark)

    Weeke, Peter; Roden, Dan M

    2013-01-01

    Variability in drug responsiveness is a sine qua non of modern therapeutics, and the contribution of genomic variation is increasingly recognized. Investigating the genomic basis for variable responses to cardiovascular therapies has been a model for pharmacogenomics in general and has established...... resulted in changes to the product labels but also have led to development of initial clinical guidelines that consider how to facilitate incorporating genetic information to the bedside. This review summarizes the state of knowledge in cardiovascular pharmacogenomics and considers how variants described...

  10. Cardiovascular diseases and diabetes

    DEFF Research Database (Denmark)

    Green, A.; Sortso, C.; Jensen, Peter Bjødstrup

    2016-01-01

    We present an investigation of the occurrence of cardiovascular disease in patients with diabetes in Denmark 2000 through 2011. The Diabetes Impact Study 2013 is based on all registrants in the Danish National Diabetes Register as of July 3rd 2013 (n=497,232). Record linkage with the Danish...... National Patient Register was used to defining the first date of experiencing a cardiovascular event by means of a discharge diagnosis and/or having performed a coronary bypass operation or revascularization of the coronary arteries. The proportion of patients with already established CVD at the diagnosis...

  11. Implementación y resultados de un nuevo programa de ECMO para trasplante de pulmón y distrés respiratorio agudo

    Directory of Open Access Journals (Sweden)

    Eduardo San Roman

    2015-06-01

    Full Text Available RESUMEN Objetivo: El desarrollo de la membrana de oxigenación extracorpórea en América Latina representa un desafío para la especialidad. El objetivo de este artículo fue describir los resultados de un nuevo programa de membrana de oxigenación extracorpórea en una unidad de cuidados intensivos. Métodos: Estudio de cohorte retrospectivo. Incluye 22 pacientes que requirieron membrana de oxigenación extracorpórea desde Enero de 2011 hasta Junio de 2014. Se evaluaron características basales, indicaciones, duración de la corrida, días de ventilación mecánica, días de unidad de cuidados intensivos, complicaciones y mortalidad hospitalaria. Resultados: Quince pacientes requirieron membrana de oxigenación extracorpórea post-trasplante pulmonar y 7 pacientes por distrés respiratorio agudo. Todos los pacientes trasplantados fueron destetados de membrana de oxigenación extracorpórea, con una duración mediana de 3 días (Rango intercuantil - IQR: 2 - 5, de ventilación mecánica 15,5 días (IQR: 3 - 35, de estadía unidad de cuidados intensivos 31,5 días (IQR: 19 - 53 y de estadía hospitalaria 60 días (IQR: 36 - 89, con una mortalidad de 20%. Los pacientes con distrés respiratorio agudo tuvieron una mediana de duración de membrana de oxigenación extracorpórea de 9 días (IQR: 3 - 14, mediana de ventilación mecánica 25 días (IQR: 13 - 37, de estadía en terapia 31 días (IQR: 11 - 38, y hospitalaria 32 días (IQR: 11 - 41, y 57% de mortalidad. Las principales complicaciones fueron infecciones (80%, insuficiencia renal aguda (43%, sangrados en sitio quirúrgico y de inserción de cánulas (22%, plaquetopenia (60% y coagulopatía (30%. Conclusión: A pesar de encontrarnos transitando una curva de aprendizaje, consideramos la experiencia satisfactoria, con resultados y complicaciones comparables a las reportadas en la literatura.

  12. Efecto diurético agudo de los extractos etanólico y acuoso de Ceratopteris pteridoides (Hook en ratas normales

    Directory of Open Access Journals (Sweden)

    Antistio Aníbal Alviz

    2013-03-01

    Full Text Available Introducción. Ceratopteris pteridoides es un helecho semiacuático de la familia Parkeriacea, ampliamente utilizado en la medicina popular colombiana como diurético y colelitiásico, sobre el cual no existen reportes científicos que avalen su uso popular como diurético. Objetivo. Evaluar el efecto diurético agudo en dosis única y dosis repetidas a corto plazo, de los extractos etanólico y acuoso de C. pteridoides en un modelo in vivo. Materiales y métodos. El extracto etanólico total fue obtenido por maceración de la planta entera de C. pteridoides con etanol y el extracto acuoso fue obtenido por decocción a 60 °C por 15 minutos. Ambos extractos se sometieron a análisis fitoquímico preliminar y estudio histológico posterior a la administración de los extractos durante ocho días consecutivos (1.000 mg/kg. El efecto diurético se evaluó en ratas Wistar, tratadas con los extractos (500 mg/kg, en forma aguda y en dosis repetidas a corto plazo, cuantificando la eliminación de agua y la excreción renal de sodio y potasio por espectrofotometría de absorción atómica y, de cloruros, por titulación mercurimétrica. Resultados. En el modelo agudo, ambos extractos mostraron un significativo efecto diurético y de excreción renal de sodio y potasio en comparación con el control, mientras que con la administración en dosis repetidas a corto plazo mostraron efecto diurético sin eliminación de electrolitos. El estudio histopatológico no sugirió efectos tóxicos hepáticos o renales. Conclusión. Los resultados demuestran la actividad diurética de C. pteridoides y sustentan el uso popular dado a esta planta como diurético en la costa norte colombiana. Se requieren estudios posteriores que permitan aislar e identificar los compuestos responsables de la actividad y los mecanismos de acción involucrados.   doi: http://dx.doi.org/10.7705/biomedica.v33i1.611

  13. Cardiovascular risk calculation

    African Journals Online (AJOL)

    James A. Ker

    2014-08-20

    Aug 20, 2014 ... smoking and elevated blood sugar levels (diabetes mellitus). These risk ... These are risk charts, e.g. FRS, a non-laboratory-based risk calculation, and ... for hard cardiovascular end-points, such as coronary death, myocardial ...

  14. Gender and Cardiovascular Disease

    NARCIS (Netherlands)

    Den Ruijter, Hester M.; Pasterkamp, Gerard

    2015-01-01

    More women than men die of cardiovascular disease (CVD) each year in every major developed country and most emerging economies. Nonetheless, CVD has often been considered as men’s disease due to the higher rates of coronary artery disease (CAD) of men at younger age. This has led to the

  15. Cardiovascular risk prediction

    DEFF Research Database (Denmark)

    Graversen, Peter; Abildstrøm, Steen Z.; Jespersen, Lasse

    2016-01-01

    Aim European society of cardiology (ESC) guidelines recommend that cardiovascular disease (CVD) risk stratification in asymptomatic individuals is based on the Systematic Coronary Risk Evaluation (SCORE) algorithm, which estimates individual 10-year risk of death from CVD. We assessed the potential...

  16. Epigenetics and cardiovascular disease

    Science.gov (United States)

    Despite advances in the prevention and management of cardiovascular disease (CVD), this group of multifactorial disorders remains a leading cause of mortality worldwide. CVD is associated with multiple genetic and modifiable risk factors; however, known environmental and genetic influences can only...

  17. The Cardiovascular Research Grid (CVRG)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CardioVascular Research Grid (CVRG) project is creating an infrastructure for sharing cardiovascular data and data analysis tools. CVRG tools are developed using...

  18. Cold Weather and Cardiovascular Disease

    Science.gov (United States)

    ... Venous Thromboembolism Aortic Aneurysm More Cold Weather and Cardiovascular Disease Updated:Sep 16,2015 Th is winter ... and procedures related to heart disease and stroke. Cardiovascular Conditions • Conditions Home • Arrhythmia and Atrial Fibrillation • Cardiac ...

  19. Nutrition and cardiovascular health.

    Science.gov (United States)

    Berciano, Silvia; Ordovás, José M

    2014-09-01

    A multitude of studies have been published on the relationship between cardiovascular disease risk and a variety of nutrients, foods, and dietary patterns. Despite the well-accepted notion that diet has a significant influence on the development and prevention of cardiovascular disease, the foods considered healthy and harmful have varied over the years. This review aims to summarize the current scientific evidence on the cardioprotective effect of those foods and nutrients that have been considered healthy as well as those that have been deemed unhealthy at any given time in history. For this purpose, we reviewed the most recent literature using as keywords foods and nutrients (ie, meat, omega-3) and cardiovascular disease-related terms (ie, cardiovascular diseases, stroke). Emphasis has been placed on meta-analyses and Cochrane reviews. In general, there is a paucity of intervention studies with a high level of evidence supporting the benefits of healthy foods (ie, fruits and vegetables), whereas the evidence supporting the case against those foods considered less healthy (ie, saturated fat) seems to be weakened by most recent evidence. In summary, most of the evidence supporting the benefits and harms of specific foods and nutrients is based on observational epidemiological studies. The outcome of randomized clinical trials reveals a more confusing picture with most studies providing very small effects in one direction or another; the strongest evidence comes from dietary patterns. The current status of the relationship between diet and cardiovascular disease risk calls for more tailored recommendations based on genomic technologies. Copyright © 2014 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.

  20. Nonfasting hyperlipidemia and cardiovascular disease

    DEFF Research Database (Denmark)

    Nordestgaard, B G; Langsted, A; Freiberg, J J

    2009-01-01

    , total cholesterol/HDL cholesterol, and apolipoprotein B/apolipoprotein A1 all associate with increased risk of cardiovascular disease. These new data open the possibility that nonfasting rather than fasting lipid profiles can be used for cardiovascular risk prediction. If implemented, this would...... of cardiovascular disease and early death....

  1. Asian & Pacific Islanders and Cardiovascular Diseases

    Science.gov (United States)

    ... Fact Sheet 2016 Update Asian & Pacific Islanders and Cardiovascular Diseases Cardiovascular Disease (CVD) (ICD 10 codes I00-I99, Q20- ... of na- tive Hawaiians or oth- A indicates cardiovascular disease plus congenital cardiovascular disease (ICD-10 I00- ...

  2. Edema agudo pulmonar associado à obstrução das vias aéreas: relato de caso Edema agudo pulmonar asociado a la obstrucción de las vías aéreas: relato de caso Acute pulmonary edema associated with obstruction of the airways: case report

    Directory of Open Access Journals (Sweden)

    Flora Margarida Barra Bisinotto

    2008-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O edema pulmonar por pressão negativa tem sido definido como edema não-cardiogênico, com transudação de líquido para o interstício pulmonar, por aumento na pressão negativa intratorácica, ocasionado pela obstrução das vias aéreas superiores. Descreveu-se o caso de paciente hígida, submetida à anestesia geral, que apresentou edema agudo pulmonar após a extubação traqueal. RELATO DO CASO: Paciente de 23 anos, sexo feminino, estado físico ASA II, submetida à anestesia geral para videolaparoscopia ginecológica. O procedimento durou 3 horas, sem intercorrências. Após a extubação, a paciente apresentou laringoespasmo e diminuição da saturação de oxigênio. Houve melhora após colocação de cânula oral e administração de oxigênio, sob pressão positiva, com máscara facial. Estabilizado o quadro, foi encaminhada à sala de recuperação pós-anestésica, onde, logo após a admissão, apresentou edema agudo de pulmão com eliminação de secreção serossanguinolenta. O tratamento constou de elevação do dorso, oxigênio sob máscara, furosemida e restrição hídrica. A radiografia torácica mostrou imagem compatível com edema agudo pulmonar e área cardíaca normal. O eletrocardiograma (ECG, ecocardiografia e enzimas cardíacas estavam normais. A paciente apresentou boa evolução, recebendo alta hospitalar no dia seguinte, assintomática. CONCLUSÕES: O edema agudo de pulmão associado à obstrução das vias aéreas superiores é condição clínica que pode agravar procedimentos cirúrgicos de baixa morbidade e que aparece sobretudo em pacientes jovens. O tratamento deve ser instituído precocemente, pois a resolução também é rápida e, na maioria das vezes, sem seqüelas.JUSTIFICATIVA Y OBJETIVOS: El edema pulmonar por presión negativa ha sido definido como edema no cardiogénico, con transudación de líquido para el intersticio pulmonar, por aumento en la presión negativa

  3. Suspeita de Apneia Obstrutiva do Sono definida pelo Questionário de Berlim prediz eventos em pacientes com Síndrome Coronariana Aguda Sospecha de apnea obstructiva del sueño definida por el cuestionario de Berlín predice eventos en pacientes con síndrome coronario agudo Suspicion of Obstructive Sleep Apnea by Berlin Questionnaire predicts events in patients with Acute Coronary Syndrome

    Directory of Open Access Journals (Sweden)

    Eryca Vanessa S. de Jesus

    2010-09-01

    Full Text Available FUNDAMENTO: De um ponto de vista mecanístico, a apneia obstrutiva do sono (SAOS pode causar distúrbios extras à homeostase cardiovascular na presença de síndrome coronariana aguda (SCA. OBJETIVO: Investigar se um diagnóstico clínico padronizado de SAOS, em pacientes com SCA, prediz o risco de eventos cardiovasculares durante hospitalização. MÉTODOS: Em um estudo de coorte prospectivo, um grupo de 200 pacientes com diagnóstico de SCA estabelecido entre Setembro de 2005 e Novembro de 2007, foram estratificados pelo Questionário de Berlim (QB para o risco de SAOS (alto ou baixo risco. Foi testado se o subgrupo de alto risco para SAOS apresenta maior tendência à eventos cardiovasculares. O endpoint primário avaliado foi um desfecho composto de morte cardiovascular, eventos cardíacos isquêmicos recorrentes, edema pulmonar agudo e acidente vascular cerebral durante a hospitalização. RESULTADOS: Noventa e quatro (47% dos pacientes identificados pelo QB apresentavam suspeita de SAOS. Alto risco para SAOS estava associado com uma mortalidade mais elevada, embora sem diferença estatística (4,25% vs 0,94%; p=0,189, mas com uma estatisticamente significante maior incidência de desfecho composto de eventos cardiovasculares (18,08% vs 6,6%; p=0,016. No modelo de regressão logística, os preditores multivariados de desfecho composto de eventos cardiovasculares foram idade (OR = 1,048; IC95%: 1,008 a 1,090; p=0,019, fração de ejeção do VE (OR = 0,954; IC95%: 0,920 a 0,989; p=0,010, e risco mais elevado de SAOS (OR = 3,657; IC95%: 1,216 a 10,996; p=0,021. CONCLUSÃO: O uso de um questionário simples e validado (QB para identificar pacientes com risco mais elevado de SAOS pode ajudar a prever o desfecho cardiovascular durante a hospitalização. Além disso, nossos dados sugerem que SAOS é muito comum em pacientes com SCA.FUNDAMENTO: Desde un punto de vista mecanístico, la apnea obstructiva del sueño (SAOS puede ocasionar disturbios

  4. Consideraciones cardiovasculares del síndrome de Marfán en edades pediátricas

    Directory of Open Access Journals (Sweden)

    Giselle Serrano Ricardo

    2012-06-01

    Full Text Available El síndrome de Marfán es una enfermedad hereditaria del tejido conectivo, que se describe en niños y en adultos, causada por una mutación en el gen que codifica la glicoproteína fibrilina tipo 1. Afecta múltiples órganos y sistemas, fundamentalmente cardiovascular, esquelético, oftalmológico, piel y tegumentos. Se presenta una revisión de los aspectos más actuales del diagnóstico, y la atención multidisciplinaria para lograr una reducción de la morbilidad y mortalidad en los pacientes pediátricos. Se concluye que el uso precoz de betabloqueadores e inhibidores del receptor AT-1 de la angiotensina II (losartán, constituyen actualmente los pilares fundamentales de la terapéutica farmacológica, pues disminuyen la frecuencia de complicaciones cardiovasculares, las cuales determinan el pronóstico de la enfermedad. La cirugía programada de la raíz aórtica, especialmente con preservación valvular, permite mejorar la expectativa de vida al evitar la alta mortalidad de los eventos agudos. Alternativas prometedoras son los procederes híbridos y el intervencionismo endovascular.

  5. Detecção de Treponema denticola em casos de abscesso perirradicular agudo Detection of Treponema denticola in cases of acute periradicular abscesses

    Directory of Open Access Journals (Sweden)

    Isabela das Neves RÔÇAS

    2000-09-01

    Full Text Available Nosso objetivo foi detectar Treponema denticola em casos de abscesso perirradicular agudo. O DNA extraído das amostras de pus foi examinado pelo método da "Polymerase Chain Reaction" direcionada para o gene do RNAr (fração 16S. A amplificação usando o "primer" da espécie Treponema denticola permitiu detectá-la em 5 dos 6 casos de abscessos examinados. Apenas uma banda de tamanho esperado foi observada para as amostras positivas para esta bactéria, o que foi confirmado pela comparação com o DNA de referência do Treponema denticola (controle positivo. Até o momento, este é o primeiro relato da presença desta espiroqueta, considerada um importante patógeno periodontal em infecções endodônticas. Os resultados sugerem que Treponema denticola também pode ser um importante patógeno endodôntico.The purpose of this study was to report the detection of Treponema denticola in five out of six cases of acute periradicular abscesses. The 16S rRNA gene directed Polymerase Chain Reaction was the method utilized. This is probably the first report hitherto of the occurrence of this spirochete in acute periradicular abscesses.

  6. Precisión diagnóstica de un modelo de redes bayesianas en los síndromes coronarios agudos

    Directory of Open Access Journals (Sweden)

    John Sprockel

    2015-08-01

    Full Text Available Introducción: La caracterización diagnóstica del dolor torácico, con énfasis en los síndromes coronarios agudos (SCA es un requerimiento primordial para los médicos del área de urgencias. Objetivos: En el presente estudio se busca diseñar y evaluar el desempeño de las redes bayesianas en el apoyo al diagnóstico de los SCA. Metodología: Se trata de un estudio de pruebas diagnósticas en el cual se diseñaron dos modelos de redes bayesianas entrenadas en el framework OpenMarkov, a partir de las variables de la escala de probabilidad de Braunwald de angina en un grupo de 159 pacientes que luego se validó en una cohorte de 108 pacientes adultos hospitalizados con sospecha de un SCA en un hospital de tercer nivel de atención. Resultados: Se obtuvo una sensibilidad baja aunque con especificidad y valor predictivo positivo adecuados (62, 86 y 87% respectivamente. El rendimiento fue mejor en los casos que tuvieron electrocardiograma y biomarcadores negativos. Conclusiones: Un modelo de redes Bayesianas entrenado a partir de las variables de la escala de probabilidad de angina inestable de Braunwald, presenta un rendimiento aceptable para el diagnóstico de los SCA.

  7. Tomografia computadorizada sem contraste intravenoso no abdome agudo: quando e por que usar When and why use unenhanced computed tomography in patients with acute abdomen

    Directory of Open Access Journals (Sweden)

    Edison de Oliveira Freire Filho

    2006-02-01

    Full Text Available A tomografia computadorizada sem contraste intravenoso tem sido freqüentemente proposta na avaliação inicial de pacientes com suspeita de abdome agudo, ocupando o espaço de outros métodos diagnósticos. Os autores apresentam uma revisão bibliográfica dos principais aspectos e eficácia da tomografia computadorizada sem contraste intravenoso no diagnóstico de apendicite aguda, cólica nefrética, diverticulite, pancreatite aguda, apendicite epiplóica, pneumoperitônio e obstrução intestinal. Discutem quais as vantagens e limitações desta técnica de exame, bem como seus aspectos práticos.The use of unenhanced computed tomography has been frequently recommended for the initial assessment of patients with clinical suspicion of acute abdomen instead of other diagnostic methods. The authors present a review of the literature on the main aspects, advantages, limitations and efficacy of unenhanced computed tomography for the diagnosis of acute appendicitis, renal colic, diverticulitis, acute pancreatitis, primary epiploic appendicitis, pneumoperitoneum and small bowel obstruction. The advantages and limitations of this technique are also discussed.

  8. Acute gastric volvulus: report of a case Vólvulo gástrico agudo: etiopatogénesis, diagnóstico y tratamiento

    Directory of Open Access Journals (Sweden)

    Sergio Hoyos

    1997-03-01

    Full Text Available This paper presents a case of acute gastric volvulus related to diaphragmatic elevation due to a lung resection performed twenty eight years before, as a consequence of pulmonary tuberculosis. Gastric volvulus is rarely found; the disorder is usually chronic and originales from concurrent diaphragmatic defects or derangements. Pathogenesis and diagnosis of acute gastric volvulus as well as different treatment alternatives are discussed. Se presenta un caso de vólvulo gástrico agudo asociado a elevación del diafragma, secundaria a una neumonectomía practicada 28 años antes por tuberculosis pulmonar. El vólvulo gástrico es una entidad clínica poco frecuente que ocurre, en general, en forma crónica y secundaria a patología diafragmática. Se discuten la etiopatogénesis, el diagnóstico y las diferentes alternativas de tratamiento en pacientes con esta entidad.

  9. ANÁLISIS COMPARATIVO DE LOS EFECTOS AGUDOS DE SESIONES DE ENTRENAMIENTO DE FUERZA CON CARGAS DEL 90 Y 30% 1 RM.

    Directory of Open Access Journals (Sweden)

    Jorge Dopico Calvo

    2010-10-01

    Full Text Available En una medición inicial (Pretest se obtuvo la 1RM de 23 sujetos masculinos en el ejercicio press banca, así como la potencia y fuerza media aplicada al 90 y 30% de 1RM (PMED90, FMED90, PMED30, FMED 30. Posteriormente 11 sujetos (Gr90 llevaron a cabo 2 sesiones de entrenamiento con cargas del 90%, mientras los 12 sujetos restantes (Gr30 lo hacían con cargas del 30%. Inmediatamente finalizada cada una de las sesiones se valoraba nuevamente PMED90, FMED90, PMED30, FMED30. Una semana después de la finalización de los entrenamientos se efectuó un Postest. Los resultados mostraron una mejora estadísticamente significativa del rendimiento de Gr30 al final de cada una de las sesiones de entrenamiento, respecto a Pretest y Postest, con el 90% de 1RM, mientras que Gr90 obtuvo mejoras significativas con el 30% respecto a Pretest, pero no respecto a Postest.
    PALABRAS CLAVE: fuerza, potencia, medición, efecto agudo.

  10. [Strategies for cardiovascular disease prevention].

    Science.gov (United States)

    Gabus, Vincent; Wuerzner, Grégoire; Saubade, Mathieu; Favre, Lucie; Jacot Sadowski, Isabelle; Nanchen, David

    2018-02-28

    Atherosclerosis is a disease which develops very gradually over decades. Under the influence of modifiable cardiovascular risk factors, such as blood pressure, LDL-cholesterol level, smoking or lifestyle, clinical symptoms of atherosclerosis manifest more or less early in life. When cardiovascular risk factors accumulate, the risk of having a cardiovascular event increases and the benefits of prevention measures are greater. This article summarizes existing strategies for controlling modifiable cardiovascular risk factors in primary prevention. The physician can rely on an interprofessional network of cardiovascular prevention. Managing risk factors while respecting the autonomy and priorities of the patient will bring the greatest benefit.

  11. Cardiovascular: radioisotopic angiocardiography

    International Nuclear Information System (INIS)

    Kriss, J.P.

    1975-01-01

    Radioisotopic angiocardiography, performed after the intravenous injection of 99 /sup m/Tc-labeled pertechnetate or albumin, is a simple, rapid, and safe procedure which permits identification and physiologic assessment of a wide variety of congenital and acquired cardiovascular lesions in infants and children. These include atrial and ventricular septal defect, tetralogy of Fallot, pulmonic stenosis, aortopulmonary window, transposition of the great vessels, valvular stenosis and/or insufficiency, myocardial lesions, and lesions of the great vessels. The simplicity of the procedure lends itself to repeated measurements to assess the effects of therapy or to follow the course of the disease. A wide spectrum of congenital and acquired cardiovascular diseases have been studied which have particular application to the pediatric age group. (auth)

  12. Cardiovascular manifestations of Alkaptonuria.

    Science.gov (United States)

    Pettit, Stephen J; Fisher, Michael; Gallagher, James A; Ranganath, Lakshminarayan R

    2011-12-01

    The cardiovascular manifestations of alkaptonuria relate to deposition of ochronotic pigment within heart valves, endocardium, aortic intima and coronary arteries. We assessed 16 individuals with alkaptonuria for cardiovascular disease, including full electrocardiographic and echocardiographic assessment. The self reported prevalence of valvular heart disease and coronary artery disease was low. There was a significant burden of previously undiagnosed aortic valve disease, reaching a prevalence of over 40% by the fifth decade of life. The aortic valve disease was found to increase in both prevalence and severity with advancing age. In contrast to previous reports, we did not find a significant burden of mitral valve disease or coronary artery disease. These findings are important for the clinical follow-up of patients with alkaptonuria and suggest a role for echocardiographic surveillance of patients above 40 years old.

  13. Prodrugs in Cardiovascular Therapy

    Directory of Open Access Journals (Sweden)

    Maryam Tabrizian

    2008-05-01

    Full Text Available Prodrugs are biologically inactive derivatives of an active drug intended to solve certain problems of the parent drug such as toxicity, instability, minimal solubility and non-targeting capabilities. The majority of drugs for cardiovascular diseases undergo firstpass metabolism, resulting in drug inactivation and generation of toxic metabolites, which makes them appealing targets for prodrug design. Since prodrugs undergo a chemical reaction to form the parent drug once inside the body, this makes them very effective in controlling the release of a variety of compounds to the targeted site. This review will provide the reader with an insight on the latest developments of prodrugs that are available for treating a variety of cardiovascular diseases. In addition, we will focus on several drug delivery methodologies that have merged with the prodrug approach to provide enhanced target specificity and controlled drug release with minimal side effects.

  14. Slow breathing and cardiovascular disease

    Directory of Open Access Journals (Sweden)

    Ashish Chaddha

    2015-01-01

    Full Text Available Cardiovascular disease is the leading cause of death for both men and women worldwide. Much emphasis has been placed on the primary and secondary prevention of cardiovascular disease. While depression and anxiety increase the risk of developing cardiovascular disease, cardiovascular disease also increases the risk of developing anxiety and depression. Thus, promoting optimal mental health may be important for both primary and secondary prevention of cardiovascular disease. Like lowering blood pressure, lipids, and body weight, lowering anger and hostility and improving depression and anxiety may also be an important intervention in preventive cardiology. As we strive to further improve cardiovascular outcomes, the next bridge to cross may be one of offering patients nonpharmacologic means for combating daily mental stress and promoting mental health, such as yoga and pranayama. Indeed, the best preventive cardiovascular medicine may be a blend of both Western and Eastern medicine.

  15. Cardiovascular safety of etoricoxib

    Directory of Open Access Journals (Sweden)

    Viktoriya Georgievna Barskova

    2011-01-01

    Full Text Available Meticulous attention is paid to the cardiovascular safety of nonsteroidal anti-inflammatory drugs (NSAIDs, the so-called selective cyclooxy-genase 2 (COX-2 inhibitors in particular. The author considers precisely this matter in case of Russia's recent NSAID etoricoxib that has been tested along with other most studied medications from this group, by applying one of the latest meta-analyses. The EULAR recommendations to use NSAIDs are given.

  16. Nutritional habits & cardiovascular disease

    OpenAIRE

    Sampaio, Hélia; Capitão, Sandra; Ferro-Lebres, Vera

    2010-01-01

    An elevated predominance of the risk factors associated to the illnesses of the circulatory system, particurily hypercholesterolemia and arterial hypertension aim for a special attention to its prevention. This way, the composition of the digested food daily can influence the sprouting of Cardiovascular Disease (CVD), which has shown association between the risk factors and the things we consume. The present study had an objective to identify the influential factors of social economics...

  17. Cocoa and cardiovascular health

    OpenAIRE

    Corti, R; Flammer, A J; Hollenberg, N K; Lüscher, T F

    2009-01-01

    Epidemiological data demonstrate that regular dietary intake of plant-derived foods and beverages reduces the risk of coronary heart disease and stroke. Among many ingredients, cocoa might be an important mediator. Indeed, recent research demonstrates a beneficial effect of cocoa on blood pressure, insulin resistance, and vascular and platelet function. Although still debated, a range of potential mechanisms through which cocoa might exert its benefits on cardiovascular health have been propo...

  18. [Thyroid and cardiovascular disorders].

    Science.gov (United States)

    Zyśko, Dorota; Gajek, Jacek

    2004-05-01

    In this study three problems concerning interactions between thyroid and cardiovascular system are discussed. Cardiac arrhythmias, congestive heart failure, pleural effusion, hyperlipidaemia, arterial hypertension may be consequences of thyroid disorders leading to inappropriate hormone secretion. During such illnesses as heart failure, myocardial infarction and in patients undergoing coronary artery bypass surgery profound changes may occur in thyroid hormone metabolism known as sick euthyroid syndrome. Treatment with amiodarone may lead to changes in thyroid tests results and to development of hypothyroidism or thyrotoxicosis.

  19. Cardiovascular Molecular Imaging

    International Nuclear Information System (INIS)

    Lee, Kyung Han

    2009-01-01

    Molecular imaging strives to visualize processes in living subjects at the molecular level. Monitoring biochemical processes at this level will allow us to directly track biological processes and signaling events that lead to pathophysiological abnormalities, and help make personalized medicine a reality by allowing evaluation of therapeutic efficacies on an individual basis. Although most molecular imaging techniques emerged from the field of oncology, they have now gradually gained acceptance by the cardiovascular community. Hence, the availability of dedicated high-resolution small animal imaging systems and specific targeting imaging probes is now enhancing our understanding of cardiovascular diseases and expediting the development of newer therapies. Examples include imaging approaches to evaluate and track the progress of recent genetic and cellular therapies for treatment of myocardial ischemia. Other areas include in vivo monitoring of such key molecular processes as angiogenesis and apoptosis. Cardiovascular molecular imaging is already an important research tool in preclinical experiments. The challenge that lies ahead is to implement these techniques into the clinics so that they may help fulfill the promise of molecular therapies and personalized medicine, as well as to resolve disappointments and controversies surrounding the field

  20. Psoriasis and cardiovascular events

    DEFF Research Database (Denmark)

    Raaby, Line; Ahlehoff, Ole; de Thurah, Annette

    2017-01-01

    So far, systematic reviews have suggested an increased risk of cardiovascular diseases (CVD) in psoriatic patients, though some results have been conflicting. The aim of this study was to update the current level of evidence through a systematic search in MEDLINE, EMBASE and Cochrane Central...... Register databases. In total, 13 high-quality observational studies estimating the incidence of CVD were included. Patients with mild psoriasis had an increased risk of stroke [Hazard ratio (HR) = 1.10, 95% CI: 1.0-1.19] and myocardial infarction (MI) (HR = 1.20, 95% CI: 1.06-1.35), but not cardiovascular...... death. The risks of both stroke (HR = 1.38, 95% CI: 1.20-1.60), MI (HR = 1.70, 95% CI: 1.18-2.43) and cardiovascular death (HR = 1.37, 95% CI: 1.13-1.67) were increased in patients with severe psoriasis. In conclusion, this updated meta-analysis confirmed that patients with psoriasis have an increased...

  1. Consideraciones cardiovasculares del síndrome de Marfán en edades pediátricas Cardiovascular considerations about Marfan's syndrome at pediatric ages

    Directory of Open Access Journals (Sweden)

    Giselle Serrano Ricardo

    2012-06-01

    Full Text Available El síndrome de Marfán es una enfermedad hereditaria del tejido conectivo, que se describe en niños y en adultos, causada por una mutación en el gen que codifica la glicoproteína fibrilina tipo 1. Afecta múltiples órganos y sistemas, fundamentalmente cardiovascular, esquelético, oftalmológico, piel y tegumentos. Se presenta una revisión de los aspectos más actuales del diagnóstico, y la atención multidisciplinaria para lograr una reducción de la morbilidad y mortalidad en los pacientes pediátricos. Se concluye que el uso precoz de betabloqueadores e inhibidores del receptor AT-1 de la angiotensina II (losartán, constituyen actualmente los pilares fundamentales de la terapéutica farmacológica, pues disminuyen la frecuencia de complicaciones cardiovasculares, las cuales determinan el pronóstico de la enfermedad. La cirugía programada de la raíz aórtica, especialmente con preservación valvular, permite mejorar la expectativa de vida al evitar la alta mortalidad de los eventos agudos. Alternativas prometedoras son los procederes híbridos y el intervencionismo endovascular.Marfan syndrome is a hereditary disease of the connective tissue caused by mutation of type 1 fibrillin glycoprotein-coding gene in children and adults. This disease affects organs and systems, mainly cardiovascular, skeletal, ophthalmologic systems, skin and teguments. The review of the most current aspects of diagnosis, and the multidisciplinary care to reduce morbidity and mortality of pediatric patients were presented. It was concluded that the early use of betablockers and angiotensin II AT-1 receptor blocker (losarfan are the fundamental pillars of drug therapy, since they reduce the frequency of cardiovascular complications that determine the disease prognosis. The scheduled surgery of the aortic root, particularly valve preservation, allows improving the life expectancies because it prevents high mortality from acute events. Hybrid procedures and

  2. Cardiovascular magnetic resonance in adults with previous cardiovascular surgery.

    Science.gov (United States)

    von Knobelsdorff-Brenkenhoff, Florian; Trauzeddel, Ralf Felix; Schulz-Menger, Jeanette

    2014-03-01

    Cardiovascular magnetic resonance (CMR) is a versatile non-invasive imaging modality that serves a broad spectrum of indications in clinical cardiology and has proven evidence. Most of the numerous applications are appropriate in patients with previous cardiovascular surgery in the same manner as in non-surgical subjects. However, some specifics have to be considered. This review article is intended to provide information about the application of CMR in adults with previous cardiovascular surgery. In particular, the two main scenarios, i.e. following coronary artery bypass surgery and following heart valve surgery, are highlighted. Furthermore, several pictorial descriptions of other potential indications for CMR after cardiovascular surgery are given.

  3. Circunferência abdominal como preditor de evolução em 30 dias na síndrome coronariana aguda Circunferencia abdominal como predictor de evolución en 30 días en el Síndrome Coronario Agudo Abdominal circumference as a predictor of 30-day outcome in acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Priscilla Azambuja Lopes de Souza

    2011-05-01

    Full Text Available FUNDAMENTO: A circunferência abdominal (CA é a medida que mais se correlaciona com os fatores de risco e morte por doença cardiovascular. Entretanto, o impacto da obesidade no prognóstico de pacientes com doenças cardiovasculares permanece controverso e requer maiores esclarecimentos. OBJETIVO: Avaliar a CA como preditor de evolução em 30 dias em pacientes que internaram com síndrome coronariana aguda (SCA, em hospital de referência no tratamento de doenças cardiovasculares. MÉTODOS: Coorte contemporânea com 267 pacientes que internaram por SCA e que foram seguidos por 30 dias após a alta levando em consideração os eventos cardiovasculares maiores - MACE - (óbito, reinfarto, reinternação para procedimentos de revascularização. Nas primeiras 24 horas da admissão, os pacientes responderam a um questionário e posteriormente tiveram a CA mensurada. A análise estatística foi realizada com SPSS 17.0, utilizando o teste do Qui-quadrado para variáveis categóricas e o teste t de Student para as variáveis numéricas, com o nível de significância de p FUNDAMENTO: La circunferencia abdominal (CA es la medición que se correlaciona con los factores de riesgo y la muerte por enfermedad cardiovascular. Sin embargo, el impacto de la obesidad en el pronóstico de los pacientes con enfermedades cardiovasculares sigue siendo controvertido y requiere una mayor clarificación. OBJETIVO: Evaluar la CA como un predictor de evolución en 30 días en pacientes que fueron hospitalizados con síndrome coronario agudo (SCA, en un hospital de referencia para el tratamiento de las enfermedades cardiovasculares. MÉTODOS: Cohorte contemporánea con 267 pacientes que fueron hospitalizados por SCA y que fueron seguidos durante 30 días después del alta, teniendo en cuenta los eventos cardiovasculares mayores - MACE - (muerte, reinfarto, rehospitalización por procedimientos de revascularización. En las primeras 24 horas del ingreso, los pacientes

  4. Cardiovascular system aging

    OpenAIRE

    Ocampo, José M; Gutiérrez, Javier

    2005-01-01

    El envejecimiento del sistema cardiovascular está asociado con un número característico de cambios a nivel bioquímico, histológico y morfológico. Sin embargo, no todas las modificaciones presentadas se asocian con deterioro en la función. Entre los cambios a nivel cardiaco se tienen: disminución en el número de miocitos y en las células del sistema de conducción cardiaca, desarrollo de fibrosis, cambios en el transporte de calcio a través de las membranas y disminución del cronotropismo, inot...

  5. Cardiovascular Physiology of Dinosaurs.

    Science.gov (United States)

    Seymour, Roger S

    2016-11-01

    Cardiovascular function in dinosaurs can be inferred from fossil evidence with knowledge of how metabolic rate, blood flow rate, blood pressure, and heart size are related to body size in living animals. Skeletal stature and nutrient foramen size in fossil femora provide direct evidence of a high arterial blood pressure, a large four-chambered heart, a high aerobic metabolic rate, and intense locomotion. But was the heart of a huge, long-necked sauropod dinosaur able to pump blood up 9 m to its head? ©2016 Int. Union Physiol. Sci./Am. Physiol. Soc.

  6. Acute clinical events in patients with sickle cell disease: epidemiology and treatment Eventos agudos em doença falciforme: epidemiologia e tratamento

    Directory of Open Access Journals (Sweden)

    Monique M. Loureiro

    2008-04-01

    Full Text Available Sickle cell disease is a hereditary illness of high prevalence in black population, and involved patients frequently have multiple hospitalizations. Our objective was to describe and to analyze the clinical course of hospitalizations in patients with sickle cell disease. Cross-sectional study of 78 patients submitted to 230 hospital admissions due to acute complications of sickle cell disease, from 2000 to 2004 in a public teaching hospital in Rio de Janeiro city, RJ, Brazil. Outcomes variables were length of hospital stay and death. Main covariables were age, gender, chronic renal failure, causes of hospitalization and use of medicines. Proportions were compared using the chi-square or the Fischer test, and for the continuous variables, Mann-Whitney test was used. The median age in years was 20.3 (15-53 and the most frequent clinical event was acute painful episode (73.5%. Mean length of stay was significantly higher in admissions caused by different reasons than acute painful episode (p A doença falciforme é uma doença hereditária, de alta prevalência na população negra, que leva a múltiplas internações hospitalares. Nosso objetivo foi descrever e analisar o curso clínico de pacientes com doença falciforme hospitalizados.Realizou-se estudo transversal de 78 pacientes submetidos a 230 internações hospitalares devido a complicações agudas da doença falciforme, de 2000 a 2004, em um hospital universitário no Rio de Janeiro-RJ, Brasil. Os desfechos estudados foram tempo de permanência hospitalar e óbito. As principais co-variáveis foram idade, sexo, presença de insuficiência renal crônica, causas de hospitalização e uso de medicamentos. Proporções foram comparadas utilizando-se o teste qui-quadrado ou teste de Fischer, e, para as variáveis contínuas, o teste de Mann-Whitney foi utilizado. A mediana da idade foi 20,3 anos (15-23 e o evento clínico mais freqüente foi o episódio doloroso agudo (73,5%. O tempo m

  7. Precision Medicine in Cardiovascular Diseases

    Directory of Open Access Journals (Sweden)

    Yan Liu

    2017-02-01

    Full Text Available Since President Obama announced the Precision Medicine Initiative in the United States, more and more attention has been paid to precision medicine. However, clinicians have already used it to treat conditions such as cancer. Many cardiovascular diseases have a familial presentation, and genetic variants are associated with the prevention, diagnosis, and treatment of cardiovascular diseases, which are the basis for providing precise care to patients with cardiovascular diseases. Large-scale cohorts and multiomics are critical components of precision medicine. Here we summarize the application of precision medicine to cardiovascular diseases based on cohort and omic studies, and hope to elicit discussion about future health care.

  8. Síndrome de Distrés Respiratorio Agudo: Utilidad de los Corticoides Acute respiratory distress syndrome: Role of steroids

    Directory of Open Access Journals (Sweden)

    Célica L. Irrazábal

    2004-06-01

    Full Text Available En Argentina, el síndrome de distrés respiratorio agudo (SDRA representa el 7.7% de las admisiones en terapia intensiva y está asociado con una alta morbilidad y mortalidad (58%. Con frecuencia la muerte puede ser atribuida a más de una causa. La hipoxemia refractaria es una causa de muerte poco frecuente (15% y en muchos casos puede coexistir con disfunción multiorgánica, sepsis o shock séptico. La utilidad de los esteroides como parte del tratamiento es aún motivo de debate a pesar de las múltiples series de casos y estudios clínicos publicados. En el artículo se evalúa la utilidad de los esteroides en el SDRA a través de la revisión de la bibliografía disponible. Se concluye que los esteroides estarían indicados en un pequeño subgrupo de pacientes con SDRA no resuelto o tardío, después de descartar o controlar una infección activa.The acute respiratory distress syndrome (ARDS represents 7.7% of the intensive care population, and is associated with great morbidity and mortality (58%. Frequently, the mortality can be attributed to more than one cause. Refractory hypoxemia is uncommon (15% and most of the patients also have multiple organic dysfunction, sepsis or septic shock. Although there are many publications concerning series of cases and clinical trials using steroids as a part of the treatment of ARDS, this issue remains controversial. In this article the role of steroids in the ARDS is evaluated by analysis of the available literature. We conclude that steroids are useful in a subgroup of patients with unresolving ARDS, after ruling out an active infection or after treatment with antibiotics.

  9. Acute psychotic disorders induced by topiramate: report of two cases Episódio psicótico agudo induzido por topiramato: relato de dois casos

    Directory of Open Access Journals (Sweden)

    Florindo Stella

    2002-06-01

    Full Text Available We report on two epileptic patients who developed acute psychosis after the use of topiramate (TPM. One patient exhibited severe psychomotor agitation, heteroaggressiveness, auditory and visual hallucinations as well as severe paranoid and mystic delusions. The other patient had psychomotor agitation, depersonalization, derealization, severe anxiety and deluded that he was losing his memory. Both patients had to be taken to the casualty room. After interruption of TPM in one patient and reduction of dose in the other, a full remission of the psychotic symptoms was obtained without the need of antipsychotic drugs. Clinicians should be aware of the possibility of development of acute psychotic symptoms in patients undergoing TPM treatment.Relatamos dois pacientes epilépticos que manifestaram quadro psicótico agudo induzido por topiramato (TPM. Um paciente apresentou agitação psicomotora grave, heteroagressividade, alucinações auditivas e visuais, e delírios de conteúdo paranóide e místico. O outro paciente apresentou agitação psicomotora, despersonalização, desrealização, ansiedade intensa e delírio de que estava perdendo a memória. Ambos os pacientes foram conduzidos ao serviço de emergência e, após a interrupção do TPM em um deles e redução da droga em outro, houve remissão total dos sintomas psicóticos sem necessidade de medicação antipsicótica. Alertamos os clínicos para o risco de surgimento de sintomas psicóticos em pacientes em uso do TPM.

  10. Riesgo familiar total en salud y grado de salud familiar en las familias de los pacientes con diagnostico de síndrome coronario agudo

    Directory of Open Access Journals (Sweden)

    Ruby Elizabeth Vargas-Toloza

    2012-12-01

    Full Text Available Objetivo: identificar el riesgo familiar total en salud y grado de salud familiar en las familias de los pacientes con diagnóstico de síndrome coronario agudo de la Clínica San José de Cúcuta. Materiales y Métodos: Estudio cuantitativo, de tipo descriptivo transversal; en el que se calculó una muestra de 165 familias por muestreo no probabilístico. La recolección de la información se realizo por medio de los instrumentos RFT: 5-33 y ISF GEN-21 donde se clasifico el riesgo familiar total y se percibió el grado de salud familiar. Resultados: se evidencia que las familias están conformes con el modelo habitual de organización familiar en función de cada uno de los integrantes y del grupo como tal. Lo cual nos indica que toda la familia del paciente coronario lo ayuda a sobrellevar el proceso de salud-enfermedad y tiene claro el papel que juega dentro de ella permitiendo así la funcionalidad y la unidad que requiere este tipo de pacientes para su rehabilitación. Conclusiones: los factores de riesgo biológicos, sociales y del medio ambiente que clasifican a la población estudiada dentro de riesgo familiar bajo. Se evidenció un alto grado de organización y satisfacción asegurando en gran medida la adaptación y el éxito de las familias frente al proceso de salud- enfermedad por la que atraviesan algunos de los miembros especialmente si es un paciente coronario.

  11. Los efectos agudos de la contaminación del aire en la salud de la población: evidencias de estudios epidemiológicos

    Directory of Open Access Journals (Sweden)

    Rosales-Castillo José Alberto

    2001-01-01

    Full Text Available Objetivo. Sintetizar las evidencias de los efectos en la salud de la población por la exposición a contaminación del aire por ozono y partículas suspendidas. Material y métodos. A partir de las principales publicaciones internacionales y mexicanas, publicadas y referidas hasta junio del año 2000, se realizó un metanálisis para resumir los efectos reportados a través del empleo de modelos de efectos aleatorios. Resultados. Los resultados se expresaron como porcentajes de incremento por 10 unidades de concentración de PM10 (µg/m³ y ozono (ppb. Entre los efectos de PM10 cabe destacar el efecto agudo en la mortalidad (0.96%, hospitalizaciones (1.39%, visitas a salas de urgencias (3.11%, síntomas respiratorios (7.72%, parámetros de función pulmonar (1.42%, para capacidad vital forzada (CVF y días de actividad restringida (7.74%. Los efectos de la exposición a ozono son igualmente significativos. Conclusiones. Estos resultados muestran el gran impacto que las concentraciones de contaminantes del aire podrían tener en la salud de las poblaciones urbanas de las grandes metrópolis. El texto completo en inglés de este artículo está disponible en: http://www.insp.mx/salud/index.html

  12. Efeito agudo da imagética no desempenho de lances livres e percepção de autoeficácia em atletas

    Directory of Open Access Journals (Sweden)

    Thiago Ferreira Dias Kanthack

    2013-12-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2014v16n1p47 O esporte cada vez mais diferencia vencedores e perdedores por mínimos detalhes. No basquetebol um fator diferenciador é o lance livre. Sessões de imagética motora (IMA vêm sendo estudada como um ergogênico sobre o desempenho de lance livre, porém, pouco se estuda o seu efeito agudo, principalmente, em atletas. O objetivo desse estudo foi verificar o efeito de uma sessão prévia de treinamento mental sobre o desempenho no lance livre e na percepção de autoeficácia de jovens atletas. Participaram do estudo 11 atletas juvenis da Federação Paulista de Basquete. Na condição IMA, foram submetidos a 1 minuto de vídeo + 3 minutos de imagética, seguidos de 10 lances livres, e no controle, 4 minutos de repouso seguidos de 10 lances livres. O questionário de autoeficácia foi preenchido antes e após a intervenção. Para análise estatística, foram utilizados os testes U de Mann-Withney, Wilcoxon e o Smallest Wothwhille Change (SWC. Não foi encontrada diferença entre a mediana dos grupos, porém, o SWC apontou uma possibilidade de 84% de efeito benéfico do treinamento mental sobre o desempenho para até 2 lances livres. Concluiu-se que a imagética motora prévia tem 84% de chance de causar um efeito benéfico sobre o desempenho de lance livre em até 2 arremessos.

  13. El estrés agudo modifica la recuperación y la extinción de la memoria espacial en función de su intensidad

    OpenAIRE

    Cuestas Diana Marcela; Troncoso Julieta

    2007-01-01

    Para evaluar los efectos del estrés agudo por restricción de movimientos sobre la recuperación y la extinción
    de la memoria espacial sin sobreentrenamiento, se utilizaron tres grupos de ratas: control, estrés una hora
    y estrés cuatro horas. Todos los animales fueron entrenados en el laberinto circular de Barnes. El protocolo
    de entrenamiento constaba de ocho ensayos de adquisición (intervalo entre ensayos, IEE; 5 min). Los animales de todos los grupos experime...

  14. Ablación miocárdica septal transluminal percutánea en pacientes con miocardiopatía hipertrófica septal obstructiva: Resultados agudos y seguimiento a 3 años

    OpenAIRE

    Llamas-Esperón,Guillermo A.; Loera Pinales,Armando; Sandoval Navarrete,Santiago; Zamora Muciño,Alberto; Ramírez Robledo,Miguel A.; Varela Ortiz,Samuel; Casas Juárez,Ulices; Fuantos Delgado,María de la Luz; Albarrán Domínguez,Javier; Muñoz Sandoval,Rocío; Sandoval Rodríguez,Eufracino; Ruiz Esparza,M. Eugenia

    2009-01-01

    Objetivo: Reportar los resultados agudos y a largo plazo de la ablación miocárdica septal transluminal percutánea (AMSTP) como tratamiento de la miocardiopatía hipertrófica septal obstructiva (MHSO). La AMSTP se considera una alternativa del tratamiento quirúrgico en pacientes con MHSO y sintomatología refractaria a otras opciones de tratamiento. La respuesta aguda suele ser satisfactoria, pero los resultados a largo plazo no se han descrito de forma suficiente. Métodos: Realizamos AMSTP en 8...

  15. Diferencias en tiempos de incapacidad según el tipo de manejo (convencional o temprano), en pacientes con dolor lumbar agudo secundario a accidentes de trabajo en una aseguradora de riesgos profesionales (ARP) de Bogotá, Colombia

    OpenAIRE

    Cortes Iza, Sandra Catalina; Espinosa Muñoz, Yiseth Andrea; Montenegro Castillo, María Juliana

    2010-01-01

    A lo largo de la historia se ha encontrado que el dolor lumbar agudo es una patología de alta prevalencia y costo, lo ha llevado a varios países a considerarlo un problema de salud pública, Sin embargo ha sido subvalorada y aun no se toman las medidas preventivas lo que aumenta los costos de atención para los servicios de salud y para las empresas es una causa importante de disminución de la producción por días de incapacidad. Con el fin de establecer si el tiempo de inicio y tipo del trat...

  16. Efectividad y seguridad de la laparotomía vs laparoscopía en abdomen agudo de origen gineco-obstétrico causado por embarazo ectópico roto y quiste de ovario roto.

    OpenAIRE

    Luna Aveiga, Cristhian

    2014-01-01

    Comparar efectividad, tiempo y sangrado operatorio, estadía y complicaciones entre laparotomía y laparoscopía en abdomen agudo (AA) por embarazo ectópico roto (EER) y quiste de ovario roto (QOR). Métodos: Estudio retrospectivo en el Hospital de Santa Elena y Clínica Granados de Enero 2010-Diciembre 2011. Se obtuvieron las causas, procedimientos, edad, hemoglobina, edad gestacional, antecedentes personales y complicaciones. Tiempo, sangrado operatorio y estadía fueron comparadas por T de stud...

  17. Cardiovascular Complications of Pregnancy

    Science.gov (United States)

    Gongora, Maria Carolina; Wenger, Nanette K.

    2015-01-01

    Pregnancy causes significant metabolic and hemodynamic changes in a woman’s physiology to allow for fetal growth. The inability to adapt to these changes might result in the development of hypertensive disorders of pregnancy (hypertension, preeclampsia or eclampsia), gestational diabetes and preterm birth. Contrary to previous beliefs these complications are not limited to the pregnancy period and may leave permanent vascular and metabolic damage. There is in addition, a direct association between these disorders and increased risk of future cardiovascular disease (CVD, including hypertension, ischemic heart disease, heart failure and stroke) and diabetes mellitus. Despite abundant evidence of this association, women who present with these complications of pregnancy do not receive adequate postpartum follow up and counseling regarding their increased risk of future CVD. The postpartum period in these women represents a unique opportunity to intervene with lifestyle modifications designed to reduce the development of premature cardiovascular complications. In some cases it allows early diagnosis and treatment of chronic hypertension or diabetes mellitus. The awareness of this relationship is growing in the medical community, especially among obstetricians and primary care physicians, who play a pivotal role in detecting these complications and assuring appropriate follow up. PMID:26473833

  18. Cardiovascular benefits of exercise

    Directory of Open Access Journals (Sweden)

    Agarwal SK

    2012-06-01

    Full Text Available Shashi K AgarwalMedical Director, Agarwal Health Center, NJ, USAAbstract: Regular physical activity during leisure time has been shown to be associated with better health outcomes. The American Heart Association, the Centers for Disease Control and Prevention and the American College of Sports Medicine all recommend regular physical activity of moderate intensity for the prevention and complementary treatment of several diseases. The therapeutic role of exercise in maintaining good health and treating diseases is not new. The benefits of physical activity date back to Susruta, a 600 BC physician in India, who prescribed exercise to patients. Hippocrates (460–377 BC wrote “in order to remain healthy, the entire day should be devoted exclusively to ways and means of increasing one's strength and staying healthy, and the best way to do so is through physical exercise.” Plato (427–347 BC referred to medicine as a sister art to physical exercise while the noted ancient Greek physician Galen (129–217 AD penned several essays on aerobic fitness and strengthening muscles. This article briefly reviews the beneficial effects of physical activity on cardiovascular diseases.Keywords: exercise, cardiovascular disease, lifestyle changes, physical activity, good health

  19. Cardiovascular Complications of Pregnancy

    Directory of Open Access Journals (Sweden)

    Maria Carolina Gongora

    2015-10-01

    Full Text Available Pregnancy causes significant metabolic and hemodynamic changes in a woman’s physiology to allow for fetal growth. The inability to adapt to these changes might result in the development of hypertensive disorders of pregnancy (hypertension, preeclampsia or eclampsia, gestational diabetes and preterm birth. Contrary to previous beliefs these complications are not limited to the pregnancy period and may leave permanent vascular and metabolic damage. There is in addition, a direct association between these disorders and increased risk of future cardiovascular disease (CVD, including hypertension, ischemic heart disease, heart failure and stroke and diabetes mellitus. Despite abundant evidence of this association, women who present with these complications of pregnancy do not receive adequate postpartum follow up and counseling regarding their increased risk of future CVD. The postpartum period in these women represents a unique opportunity to intervene with lifestyle modifications designed to reduce the development of premature cardiovascular complications. In some cases it allows early diagnosis and treatment of chronic hypertension or diabetes mellitus. The awareness of this relationship is growing in the medical community, especially among obstetricians and primary care physicians, who play a pivotal role in detecting these complications and assuring appropriate follow up.

  20. Cardiovascular diseases and periodontology.

    Science.gov (United States)

    Seymour, R A; Preshaw, P M; Thomason, J M; Ellis, J S; Steele, J G

    2003-04-01

    Cardiovascular diseases represent a widespread heterogeneous group of conditions that have significant morbidity and mortality. The various diseases and their treatments can have an impact upon the periodontium and the delivery of periodontal care. In this paper we consider three main topics and explore their relationship to the periodontist and the provision of periodontal treatment. The areas reviewed include the effect of cardiovascular drugs on the periodontium and management of patients with periodontal diseases; the risk of infective endocarditis arising from periodontal procedures; the inter-relationship between periodontal disease and coronary artery disease. Calcium-channel blockers and beta-adrenoceptor blockers cause gingival overgrowth and tooth demineralisation, respectively. Evidence suggests that stopping anticoagulant therapy prior to periodontal procedures is putting patients at a greater risk of thromboembolic disorders compared to the risk of prolonged bleeding. The relationship between dentistry and infective endocarditis remains a controversial issue. It would appear that spontaneous bacteraemia arising from a patient's oral hygiene practices is more likely to be the cause of endocarditis than one-off periodontal procedures. The efficacy of antibiotic prophylaxis is uncertain (and unlikely to be proven), and the risk of death from penicillin appears to be greater than the risk of death arising from infective endocarditis. Finally, the association between periodontal disease and coronary artery disease has been explored and there seem to be many issues with respect to data handling interpretation. Many putative mechanisms have been suggested; however, these only further highlight the need for intervention studies.

  1. Cheese and cardiovascular disease risk

    DEFF Research Database (Denmark)

    Hjerpsted, Julie Bousgaard; Tholstrup, Tine

    2016-01-01

    Abstract Currently, the effect of dairy products on cardiovascular risk is a topic with much debate and conflicting results. The purpose of this review is to give an overview of the existing literature regarding the effect of cheese intake and risk of cardiovascular disease (CVD). Studies included...

  2. Educational differences in cardiovascular mortality

    DEFF Research Database (Denmark)

    Kjøllesdal, M. K. R.; Ariansen, I.; Mortensen, L. H.

    2016-01-01

    Aims: To explore the confounding effects of early family factors shared by siblings and cardiovascular risk factors in midlife on the educational differences in mortality from cardiovascular disease (CVD). Methods: Data from national and regional health surveys in Norway (1974–2003) were linked...

  3. Mortality of mothers from cardiovascular and non-cardiovascular causes following pregnancy complications in first delivery

    DEFF Research Database (Denmark)

    Lykke, Jacob Alexander; Langhoff-Roos, Jens; Lockwood, Charles J

    2010-01-01

    cardiovascular and non-cardiovascular causes following preterm delivery, small-for-gestational-age offspring and hypertensive disorders of pregnancy. We found that preterm delivery and small-for-gestational-age were both associated with subsequent death of mothers from cardiovascular and non...... cardiovascular and non-cardiovascular causes, while hypertensive disorders of pregnancy are markers of early death of mothers from cardiovascular causes....

  4. Educational inequality in cardiovascular diseases

    DEFF Research Database (Denmark)

    Søndergaard, Grethe; Dalton, Susanne Oksbjerg; Mortensen, Laust Hvas

    2018-01-01

    AIMS: Educational inequality in diseases in the circulatory system (here termed cardiovascular disease) is well documented but may be confounded by early life factors. The aim of this observational study was to examine whether the associations between education and all cardiovascular diseases...... educational status was associated with a higher risk of cardiovascular disease, ischaemic heart disease and stroke. All associations attenuated in the within-sibship analyses, in particular in the analyses on ischaemic heart disease before age 45 years. For instance, in the cohort analyses, the hazard rate...... factors shared by siblings explained the associations between education and the cardiovascular disease outcomes but to varying degrees. This should be taken into account when planning interventions aimed at reducing educational inequalities in the development of cardiovascular disease, ischaemic heart...

  5. Women's cardiovascular health in India.

    Science.gov (United States)

    Chow, Clara K; Patel, Anushka A

    2012-03-01

    Cardiovascular diseases (CVDs) are the leading cause of death among adult women in many parts of India and a major cause of morbidity. In some parts of the world, gender inequities have been observed in cardiovascular healthcare and cardiovascular outcomes. The authors discuss the data for potential disparities in cardiovascular healthcare for women in India. Data on cardiovascular healthcare provision and CVD outcomes among women in India are generally lacking. The little available data suggest that women in rural areas, younger women and girl children with CVD are less likely to receive appropriate management than men, with this disparity most apparent in those of lower socioeconomic status and education. However, there is a particular lack of information about the prevention and management of atherosclerotic heart disease in women from a range of communities that comprise the extremely diverse population of India.

  6. Cheese and cardiovascular health

    DEFF Research Database (Denmark)

    Hjerpsted, Julie Bousgaard

    Cardiovascular diseases (CVDs) are the number one cause of mortality worldwide. Low-density lipoprotein (LDL) cholesterol is a well-known risk factor of CVD which increases after the intake of saturated fatty acids (SFA). Cheese is a dietary product commonly consumed in Western countries and known...... to contain high amounts of SFA. However, cheese also contributes with several nutrients in the diet such as essential amino acids and calcium. The aim of this thesis was to examine the effect of cheese intake on CVD risk through evidence from both observational, intervention and explorative studies....... By reviewing results from published observational studies it was concluded that cheese does not seem to increase CVD risk, despite of the high SFA content of most cheeses. A human cross-over intervention study was conducted with the purpose of investigating the effect of hard cheese intake on risk markers...

  7. Assessment of cardiovascular risk.

    LENUS (Irish Health Repository)

    Cooney, Marie Therese

    2010-10-01

    Atherosclerotic cardiovascular disease (CVD) is the most common cause of death worldwide. Usually atherosclerosis is caused by the combined effects of multiple risk factors. For this reason, most guidelines on the prevention of CVD stress the assessment of total CVD risk. The most intensive risk factor modification can then be directed towards the individuals who will derive the greatest benefit. To assist the clinician in calculating the effects of these multiple interacting risk factors, a number of risk estimation systems have been developed. This review address several issues regarding total CVD risk assessment: Why should total CVD risk be assessed? What risk estimation systems are available? How well do these systems estimate risk? What are the advantages and disadvantages of the current systems? What are the current limitations of risk estimation systems and how can they be resolved? What new developments have occurred in CVD risk estimation?

  8. Risk of cardiovascular disease

    DEFF Research Database (Denmark)

    Gejl, Michael; Starup-Linde, Jakob; Scheel-Thomsen, Jan

    2014-01-01

    AIMS: Type 2 diabetes (DM) increases the risk of cardiovascular disease. We investigated the effects of antidiabetic drugs on the composite endpoint (CE) of ischemic heart disease, heart failure or stroke in DM patients. METHODS: We conducted a nested case-control study. Cases were DM patients who......% CI: 16.88-24.12), neuropathy (OR=1.39, 95% CI: 1.05-1.85) and peripheral artery disease (OR=1.31, 95% CI: 1.02-1.69) increased the risk of CE. Biguanides (OR=0.62 95% CI; 0.54-0.71) and liraglutide (OR=0.48 95% CI; 0.38-0.62) significantly decreased the risk of CE as did statin treatment (OR=0.63, 95...

  9. RIA in cardiovascular disease

    International Nuclear Information System (INIS)

    Hourani, M.H.

    1983-01-01

    When one discusses the management of chronic cardiac diseases, and in particular congestive heart failure (CHF), one cannot but think of digitalis and the important role it plays in the management of CHF. One also has to think about digitalis toxicity and the narrow margin between the therapeutic and toxic doses of digitalis and the important role that monitoring the serum level of the drug play in preventing and/or recognizing its toxic effects. Again, RIA has something to offer the clinician in this area. The purpose of this chapter is to discuss the radioassays for CPK-MB and digoxin mainly, as well as touch upon other assays of use in evaluating patients with cardiovascular disease

  10. Cardiovascular hospitalizations and associations with environmental quality

    Science.gov (United States)

    Cardiovascular disease has been identified as a condition that may be associated with environmental factors. Air pollution in particular has been demonstrated to be associated with cardiovascular disease and atherosclerosis, which can increase the likelihood of cardiovascular eve...

  11. Cardiomiopatia de Takotsubo: uma causa rara de choque cardiogênico simulando infarto agudo do miocárdio Takotsubo cardiomiopathy: a rare cause of cardiogenic shock simulating acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Jayro Thadeu Paiva de Vasconcelos

    2005-08-01

    Full Text Available Cardiomiopatia de Takotsubo é uma causa rara de aneurisma ventricular esquerdo agudo, na ausência de coronariopatia, só recentemente descrita na literatura mundial. Os sintomas podem assemelhar-se aos do infarto agudo do miocárdio com dor torácica típica. A imagem do balonamento ventricular sugestivo de haltere ou "Takotsubo" (dispositivo utilizado no Japão para prender Octopus é característico desta nova síndrome e usualmente há desaparecimento do movimento discinético até o 18º dia do início dos sintomas, em média.Takotsubo Cardiomiopathy is a rare cause of acute left ventricular aneurysm, in the absence of coronariopathy, only recently described in world literature. Symptoms may be similar to those from acute myocardial infarction with typical thoracic pain. The image of dumbbell or Takotsubo (a device used in Japan to capture octopus suggestive ventricular ballooning is characteristic of that new syndrome and there is usually the disappearing of dyskinetic movement up to the 18th day from the beginning of the symptoms, in average.

  12. Apendicitis epiploica. Causa poco común de abdomen agudo en niños. Presentación de un caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    SA Solórzano-Morales

    2016-04-01

    requiere tratamiento con analgésicos. La mayoría de los casos han sido descritos en pacientes adultos; sin embargo, el caso que presentamos es el segundo diagnosticado en el Instituto Nacional de Pediatría.   CASO CLÍNICO: niño de 9 años con diagnóstico clínico presuntivo de apendicitis, se diagnosticó por ultrasonido y tomografía computada como apendicitis epiploica, lo que se corroboró en la pieza anatomopatológica.   CONCLUSIONES: nuestro propósito es describir la apendicitis epiploica en niños como causa de abdomen agudo, así como los hallazgos clínicos, ultrasonográficos, de tomografía computada e histopatológicos de esta patología como causa rara de abdomen agudo. Es importante que se conozca el valor de los estudios de imagen de esta entidad a fin de evitar tratamientos invasivos innecesarios.

  13. Escore TIMI no infarto agudo do miocárdio conforme níveis de estratificação de prognóstico Score TIMI en el infarto agudo de miocardio según niveles de estratificación de pronóstico TIMI risk score for acute myocardial infarction according to prognostic stratification

    Directory of Open Access Journals (Sweden)

    Jaqueline Locks Pereira

    2009-08-01

    Full Text Available FUNDAMENTO: O escore de risco TIMI (thrombolysis in myocardial infarction é derivado de ensaio clínico envolvendo pacientes elegíveis para fibrinólise. Como o perfil de risco desses casos difere do encontrado em populações não selecionadas, é importante que se analise a aplicabilidade do escore em condições clínicas habituais. OBJETIVO: Avaliar o manejo e a evolução hospitalar de pacientes internados com infarto agudo do miocárdio conforme estratificação de risco pelo escore TIMI. MÉTODOS: Foram avaliados, retrospectivamente, 103 casos de infarto agudo do miocárdio com supradesnivelamento do segmento ST, admitidos no Hospital Nossa Senhora da Conceição, em Tubarão, nos anos de 2004 e 2005. Os casos foram analisados em três grupos de risco de acordo com o escore TIMI. RESULTADOS: A mortalidade hospitalar pós-infarto foi de 17,5%. No grupo de baixo risco não houve óbito. A mortalidade foi de 8,1% no grupo de médio risco e de 55,6% no de alto risco. O risco de morte para casos de alto risco foi 14,1 vezes maior em relação aos casos de médio e baixo risco (IC95% = 4,4 a 44,1 e pFUNDAMENTO: El score de riesgo TIMI (thrombolysis in myocardial infarction se derivó de ensayo clínico que implicó a pacientes elegibles para fibrinólisis. Como el perfil de riesgo de esos casos difiere del encontrado en poblaciones no seleccionadas, es importante que se analice la aplicabilidad del score en condiciones clínicas habituales. OBJETIVO: Evaluar el manejo y la evolución hospitalaria de pacientes internados con infarto agudo de miocardio de acuerdo con la estratificación de riesgo mediante la puntuación TIMI. MÉTODOS: Se evaluaron, retrospectivamente, 103 casos de infarto agudo de miocardio con supradesnivelamiento del segmento ST, ingresados en el Hospital Nossa Senhora da Conceição, en Tubarão, en los años de 2004 y 2005. Se analizaron los casos en tres grupos de riesgo según el score TIMI. RESULTADOS: La mortalidad

  14. Trace Elements in Cardiovascular Diseases

    Energy Technology Data Exchange (ETDEWEB)

    Masironi, R. [Cardiovascular Diseases Unit, World Health Organization, Geneva (Switzerland)

    1970-07-01

    Cardiovascular diseases are the leading cause of death in industrialized countries. Their incidence increases, apparently, as a, function of technological progress so that in the future they may become a major public health problem in developing countries too. Early diagnosis and prevention are the tools best suited to curb such an alarming trend, but our knowledge of these topics is unsatisfactory, Valuable information would be obtained through a systematic investigation of trace elements in relation to cardiovascular function and to various types of cardiovascular diseases. Such studies would provide clues to the following questions: 1. Why does the incidence and type of cardiovascular disease differ from one country to another? May this be related to differences in tissue mineral concentrations among various population groups? 2. Which trace elements if any are beneficial to cardiovascular health, and which are harmful ones that may act as aetiological agents for some cardiovascular diseases? 3. Is it possible to utilize measurements of mineral element concentration for diagnostic purposes in cardiovascular disease? (author)

  15. A diferenciação da dor do infarto agudo do miocárdio entre pacientes diabéticos e não-diabéticos Diferenciación del dolor del infarto agudo de miocardio entre pacientes diabéticos y no diabéticos The difference in acute myocardial infarction pain between diabetic and non diabetic patients

    Directory of Open Access Journals (Sweden)

    Leandra de Gouveia Pacheco Gondim

    2003-12-01

    Full Text Available O estudo teve como objetivo comparar a dor do infarto agudo do miocárdio (IAM entre pacientes diabéticos e não-diabéticos. Uma amostra de 80 pacientes com IAM, divididos em 2 grupos com e sem diabetes mellitus (DM, sendo 29% diabéticos e 71% não-diabéticos. Os pacientes com DM referiram ausência de dor (pEl objetivo de este estudio fue comparar el dolor del infarto agudo de miocardio (IAM entre pacientes diabéticos y no diabéticos. La muestra la conformaron 80 pacientes con IAM divididos en dos grupos: con y sin diabetes mellitus (DM, siendo el 29% diabéticos y el 71% no diabéticos. Los pacientes con DM manifestaron ausencia de dolor (pThe goal of this study was to compare the acute myocardial infarction (AMI pain between diabetic and non diabetic patients. A sample of 80 AMI patients was divided in two groups, with and without diabetes mellitus (DM, being 29% diabetic and 71% non diabetic patients. The patients with DM said they had no pain (p<0.05 and gave lower scores for pain when compared with patients without DM. There was a significant difference between average scores for pain among diabetic and non diabetic patients (p<0.001. In conclusion, the diabetic patients presented no pain or diminished pain when compared with patients without diabetes.

  16. EL ESTRÉS AGUDO INTERFIERE CON LA EVOCACIÓN Y PROMUEVE LA EXTINCIÓN DE LA MEMORIA ESPACIAL EN EL LABERINTO DE BARNES

    Directory of Open Access Journals (Sweden)

    Julieta Troncoso

    2010-01-01

    Full Text Available Para evaluar los efectos del estrés agudo sobre la recuperación y la extinción de la memoria espacial, se utilizaron ratas entrenadas en el laberinto circular de Barnes. El entrenamiento consistió de 8 ensayos de adquisición (intervalo entre ensayos, IEE, de 5 min en donde los animales debían aprender a encontrar una caja meta ubicada en uno de los 18 agujeros del laberinto. Todos los animales adquirieron el aprendizaje espacial, ya que invirtieron menos tiempo en encontrar la caja meta y cometieron menos errores a medida que se sucedían los ensayos de entrenamiento. Veinticuatro horas después del entrenamiento se evaluó la retención y extinción del aprendizaje espacial mediante una prueba con caja meta (PCC seguida de siete pruebas sin caja (PSC, con un IEE de 5 min. Una hora y media antes de la sesión de evaluación de la memoria un grupo de animales fue sometido a estrés por restricción de movimientos durante una hora, permitiéndoles un período de recuperación de 30 min y otro grupo permaneció en su caja hogar sin manipulación (control. Los resultados indican que el estrés deteriora el proceso de evocación de la memoria espacial, ya que los animales estresados cometieron un mayor número de errores y demoraron más tiempo en encontrar la caja meta durante la PCC, respecto de los controles. Además, el estrés facilita el proceso de extinción, ya que, durante las PSCs los animales estresados no mostraron una persistencia en la exploración del agujero que, en el entrenamiento, conducía a la caja meta.

  17. Efeitos agudos de diferentes métodos de treinamento com pesos sobre o gasto energético em homens treinados

    Directory of Open Access Journals (Sweden)

    Rodrigo Ramalho Aniceto

    2013-06-01

    Full Text Available INTRODUÇÃO: O treinamento com pesos vem sendo amplamente utilizado como estratégia de controle e redução ponderal, assim o gasto energético (GE contribui de forma significativa para este processo. OBJETIVO: Comparar os efeitos agudos do método circuito (MC com o método tradicional (MT sobre o GE. MÉTODOS: Trata-se de uma pesquisa com delineamento crossover e aleatorizado, a amostra foi composta por 10 homens adultos treinados com idade entre 18 e 29 anos. Foram realizadas duas sessões experimentais com wash out de sete dias: no MC os exercícios foram realizados alternados por segmento em forma de estações, durante o MT os exercícios foram realizados em séries consecutivas. Ambos os métodos seguiram a mesma sequência de oito exercícios com o mesmo trabalho total: 60% de 1RM, 24 séries/estações e 10 repetições. O lactato sanguíneo foi coletado em repouso e a cada três séries/estações. O ar expirado foi coletado por 30 minutos antes e ~31 minutos durante todas as sessões de treinamento. O GE aeróbio de exercício (GEAE, kj e do intervalo de recuperação (GEAIR, kj foram estimados pela calorimetria indireta através da medida do consumo de oxigênio e o GE anaeróbio (GEA, kj pela concentração de lactato sanguíneo ([La]. O GE total (GET, kj foi registrado pelo somatório do GEA, GEAE e GEAIR. RESULTADOS: Os dados demonstraram que o GEA foi maior no MT do que o MC, no entanto, o GEAE, GEAIR e o GET não foram diferentes significativamente entre os métodos. O MT apresentou maior [La] do que o MC. CONCLUSÃO: Conclui-se que o MC e o MT produzem similar GET, contudo, percebe-se que o MT utiliza mais a via anaeróbia do que o MC.

  18. Modelo experimental de trauma medular agudo produzido por aparelho estereotáxico modificado Experimental model of acute spinal cord injury produced by modified steriotaxic equipment

    Directory of Open Access Journals (Sweden)

    B.B.J. Torres

    2010-02-01

    Full Text Available Foram utilizados 55 ratos machos da espécie Rattus novergicus, variedade Wistar, com o objetivo de propor um modelo experimental de trauma medular produzido por aparelho estereotáxico modificado, capaz de reproduzir clinicamente lesões medulares padronizadas. Após realização de laminectomia dorsal de T13, utilizou-se peso compressivo de 50,5g (25 animais - grupo I ou 70,5g (30 animais - grupo II, durante cinco minutos, comprimindo a medula espinhal. Os animais foram assistidos durante oito dias, por meio de testes comportamentais para avaliar a sensibilidade dolorosa, a capacidade motora, o posicionamento tátil e proprioceptivo e a capacidade de manter-se em plano inclinado. No grupo I, observaram-se déficits neurológicos moderados e transitórios, que variaram entre os animais. No grupo II, foi possível obter um trauma padronizado, caracterizado por paraplegia bilateral e simétrica dos membros posteriores, perda de propriocepção e da sensibilidade dolorosa de todos os animais. A utilização do aparelho estereotáxico desenvolvido permite reproduzir clinicamente trauma medular padronizado em ratos, de maneira simples, econômica e satisfatória, o que poderá proporcionar avanços nas investigações terapêuticas, abrangendo doenças neurodegenerativas, como é o caso do trauma medular agudo.Fifty-five male rats (Rattus novergicus, Wistar variety, were used with the purpose of suggesting an experimental model of spinal cord trauma performed by using a modified stereotaxic equipment capable to reproduce clinically (standardized pattern spinal cord injury. After dorsal laminectomy of T13, a compression was performed with 50.5g (25 animals - group I or 70.5g (30 animals - group II during five minutes on spinal cord. The animals were assisted during eight days by behavioral tests to evaluate painful sensibility, motor capacity, proprioceptive and tactil placing, and stability on inclined plan. In the group I, moderate and transitory

  19. Efeito agudo dos extensores do joelho unilateral na cadeira extensora com e sem estímulos na plataforma vibratória

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    Fernando Roberto Ferreira

    2013-10-01

    Full Text Available INTRODUÇÃO: Nos últimos anos muitos estudos foram feitos com o objetivo de avaliar a utilização da vibração mecânica como parte de treinamento para melhora do condicionamento físico. Entretanto, a maioria avaliou os efeitos dos exercícios em conjunto com o treinamento vibratório para determinar se havia melhora após o treinamento, sem avaliar os efeitos dos exercícios realizados na plataforma com e sem vibração. OBJETIVO: Avaliar o efeito agudo do exercício nos extensores do joelho, com e sem o estímulo da plataforma vibratória. MÉTODOS: Trinta indivíduos ativos, do sexo masculino, com idades entre 18 e 45 anos, realizaram, de forma randomizada, três protocolos: grupo plataforma ligada (GPL, grupo plataforma desligada (GPD e grupo controle (GC. Cada protocolo começava com aquecimento de cinco minutos em bicicleta ergométrica, com carga entre 75 e 100 watts e 70 rotações por minuto, seguido por seis séries de 10 movimentos de agachamento unilateral com intervalo de um minuto entre elas, com ou sem vibração mecânica, e terminava com o Work Test, realizado apenas no membro inferior dominante para determinação das valências físicas: trabalho, força, potência e velocidade. O grupo controle realizou apenas o Work Test após o aquecimento. RESULTADOS: Apenas a variável velocidade apresentou diferença estatisticamente significante (p < 0,05 quando comparado o GPL ao GC. CONCLUSÃO: O estímulo na plataforma vibratória não exerceu influência nas variáveis trabalho e potência dos extensores do joelho unilateral, mas, na velocidade do movimento, exerceu influência negativa causando fadiga.

  20. Implantação da linha de cuidado do infarto agudo do miocárdio no município de Belo Horizonte

    Directory of Open Access Journals (Sweden)

    Milena Soriano Marcolino

    2013-04-01

    Full Text Available FUNDAMENTO: A criação de sistemas ou linhas de cuidado ao infarto agudo do miocárdio (IAM tem o objetivo de otimizar o atendimento ao paciente, desde o diagnóstico precoce até o tratamento adequado e em tempo hábil. OBJETIVO: Avaliar a implantação da linha de cuidado do IAM, em Belo Horizonte, Minas Gerais, e seu impacto na mortalidade hospitalar por IAM. MÉTODOS: A linha de cuidado do IAM foi implantada em Belo Horizonte entre 2010 e 2011 com intuito de ampliar o acesso dos pacientes do sistema público de saúde ao tratamento preconizado pelas diretrizes vigentes. As equipes das unidades de pronto atendimento foram treinadas e foi implantado sistema de tele-eletrocardiografia nessas unidades. Os desfechos primários deste estudo observacional retrospectivo foram o número de internações e a mortalidade hospitalar por IAM, de 2009 a 2011. RESULTADOS: No período avaliado, 294 profissionais foram treinados e 563 ECGs foram transmitidos das unidades de pronto atendimento para as unidades coronarianas. Houve redução importante da taxa de mortalidade hospitalar (12,3% em 2009 versus 7,1% em 2011, p < 0,001, enquanto o número de internações por IAM permaneceu estável. Ocorreu aumento do custo médio de internação (média R$ 2.480,00 versus R$ 3.501,00, p < 0,001, aumento da proporção de internações contemplando diárias de terapia intensiva (32,4% em 2009 versus 66,1% em 2011, p < 0,001 e de pacientes internados em hospitais de alta complexidade (47,0% versus 69,6%, p < 0,001. CONCLUSÃO: A implantação da linha de cuidado do IAM permitiu maior acesso da população ao tratamento adequado e, consequentemente, redução na mortalidade hospitalar por IAM.

  1. Efeitos agudos no desempenho do salto vertical após o agachamento com banda elástica de joelho

    Directory of Open Access Journals (Sweden)

    Willy Andrade Gomes

    2015-08-01

    Full Text Available INTRODUÇÃO: A banda elástica pode afetar o desempenho durante exercícios de alta intensidade, reduzindo a ativação muscular, o que pode influenciar o efeito de potencialização pós-ativação, que depende de alta intensidade para o exercício subsequente que visa potência. Objetivo: Verificar os efeitos agudos no desempenho do salto com contramovimento (SCM após o agachamento em alta intensidade com e sem o uso da banda elástica de joelhos em sujeitos treinados em força.MÉTODOS: Participaram do estudo 14 homens (idade: 24 ± 4 anos, estatura: 176 ± 6 cm, massa corporal: 81 ± 11 kg, 1RM: 107 ± 30 kgf, treinados em força (>3 anos. Foram realizados três SCM antes e após três meio-agachamentos a 90% de 1RM nas condições com e sem a banda elástica de joelhos. Durante o SCM foram avaliados ativação muscular (IEMG do vasto lateral (VL, glúteo máximo (GM, tempo de salto (TS e impulso (IMP por meio da força vertical de reação do solo (FRSv.RESULTADOS: Os resultados mostraram que para o TS foi verificada diferença significante entre as condições pós-meio-agachamento (com e sem banda (P= 0,044, TE = 1,02, sendo que os maiores valores foram observados para a condição sem banda. Para a IEMG de VL foi verificada diferença significante entre as condições pré e pós o meio-agachamento (com banda (P= 0,029, TE = 1,68, sendo que os maiores valores foram observados para a IEMG com banda. Para a IEMG de GM e para o IMP não foram verificadas diferenças significantes entre as condições.CONCLUSÃO: Após a utilização da banda elástica de joelhos durante o exercício agachamento, ocorreu uma redução na participação do vasto lateral durante o salto com contramovimento, afetando o tempo de contato, mas não a produção de impulso, e consequente desempenho.

  2. Níveis de PCR são maiores em pacientes com síndrome coronariana aguda e supradesnivelamento do segmento ST do que em pacientes sem supradesnivelamento do segmento ST Niveles de PCR son mayores en pacientes con síndrome coronario agudo y supradesnivel del segmento ST que en pacientes sin supradesnivel del segmento ST CRP levels are higher in patients with ST elevation than non-ST elevation acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Syed Shahid Habib

    2011-01-01

    Full Text Available FUNDAMENTO: Há grande interesse no uso de proteína C-reativa de alta sensibilidade (PCR-as para avaliação de risco. Altos níveis de PCR-as no início da síndrome coronária aguda (SCA, antes da necrose tecidual, pode ser um marcador substituto para comorbidades cardiovasculares. OBJETIVO: Dessa forma, nosso objetivo foi estudar diferentes medidas de seguimento de níveis de PCR-as em pacientes com SCA e comparar as diferenças entre infarto do miocárdio sem elevação do segmento ST (NSTEMI com pacientes apresentando elevação do segmento ST (STEMI. MÉTODOS: Este é um estudo observacional. Dos 89 pacientes recrutados, 60 apresentavam infarto agudo do miocárdio (IAM. Três níveis seriados de PCR-us, a nível basal na hospitalização antes de 12 horas após inicio dos sintomas, níveis de pico 36-48 horas após hospitalização e níveis de acompanhamento após 4 a 6 semanas foram analisados e comparados entre pacientes com (IAMCSST e sem supradesnivelamento do segmento ST (IAMSSST. RESULTADOS: Pacientes com IAMCSST tinham IMC significantemente mais alta quando comparados com pacientes IAMSSST. Os níveis de creatino quinase fração MB (CK-MB e aspartato aminotransferase (AST eram significantemente mais altos em pacientes com IAMCSST quando comparados com pacientes com IAMSSST (pFUNDAMENTO: Hay gran interés en el uso de proteína C-reactiva de alta sensibilidad (PCR-as para evaluación de riesgo. Altos niveles de PCR-as en el comienzo del síndrome coronario agudo (SCA, antes de la necrosis tisular, puede ser un marcador sustituto para comorbilidades cardiovasculares. OBJETIVO: De esa forma, nuestro objetivo fue estudiar diferentes medidas de seguimiento de niveles de PCR-as en pacientes con SCA y comparar las diferencias entre infarto de miocardio sin elevación del segmento ST (NSTEMI con pacientes presentando elevación del segmento ST (STEMI. MÉTODOS: Este es un estudio observacional. De los 89 pacientes reclutados, 60

  3. Tratamiento del episodio agudo de asma bronquial en los servicios de urgencias pediátricos: Guía clínica práctica Treatment of the acute episode of bronchial asthma at the pediatric emergency services: Practical clinical guide

    Directory of Open Access Journals (Sweden)

    Roberto Razón Behar

    2005-12-01

    Full Text Available Por lo general, no existe una sistematización para clasificar y tratar el episodio agudo de asma bronquial ni para evaluar la evolución de los pacientes. Se realizó un estudio en 142 pacientes de 6 a 15 años de edad, que presentaron episodios agudos de asma bronquial y acudieron a los servicios de urgencias de los Hospitales Pediátricos «William Soler» y «Leonor Pérez», y del Policlínico «Federico Capdevila». A estos pacientes se les aplicó una guía clínica práctica, que incluyó la clasificación de la severidad del episodio agudo y un esquema de tratamiento, basado en la utilización de oxígeno, broncodilatadores inhalados y esteroides orales. Durante el tratamiento, los pacientes se evaluaron con periodicidad. La respuesta al tratamiento fue buena en la mayoría de los casos y el resultado final fue el egreso domiciliario. Ocho de los pacientes requirieron ingreso hospitalario por respuestas al tratamiento incompletas o pobres. La atención del episodio agudo de asma bronquial puede mejorarse con el uso de guías clínicas prácticas de diagnóstico y tratamiento.

  4. Cardiovascular MRI with ferumoxytol

    International Nuclear Information System (INIS)

    Finn, J.P.; Nguyen, K.-L.; Han, F.; Zhou, Z.; Salusky, I.; Ayad, I.; Hu, P.

    2016-01-01

    The practice of contrast-enhanced magnetic resonance angiography (CEMRA) has changed significantly in the span of a decade. Concerns regarding gadolinium (Gd)-associated nephrogenic systemic fibrosis in those with severely impaired renal function spurred developments in low-dose CEMRA and non-contrast MRA as well as efforts to seek alternative MR contrast agents. Originally developed for MR imaging use, ferumoxytol (an ultra-small superparamagnetic iron oxide nanoparticle), is currently approved by the US Food and Drug Administration for the treatment of iron deficiency anaemia in adults with renal disease. Since its clinical availability in 2009, there has been rising interest in the scientific and clinical use of ferumoxytol as an MR contrast agent. The unique physicochemical and pharmacokinetic properties of ferumoxytol, including its long intravascular half-life and high r 1 relaxivity, support a spectrum of MRI applications beyond the scope of Gd-based contrast agents. Moreover, whereas Gd is not found in biological systems, iron is essential for normal metabolism, and nutritional iron deficiency poses major public health challenges worldwide. Once the carbohydrate shell of ferumoxytol is degraded, the elemental iron at its core is incorporated into the reticuloendothelial system. These considerations position ferumoxytol as a potential game changer in the field of CEMRA and MRI. In this paper, we aim to summarise our experience with the cardiovascular applications of ferumoxytol and provide a brief synopsis of ongoing investigations on ferumoxytol-enhanced MR applications.

  5. Depression and cardiovascular disease.

    Science.gov (United States)

    Elderon, Larkin; Whooley, Mary A

    2013-01-01

    Approximately one out of every five patients with cardiovascular disease (CVD) suffers from major depressive disorder (MDD). Both MDD and depressive symptoms are risk factors for CVD incidence, severity and outcomes. Great progress has been made in understanding potential mediators between MDD and CVD, particularly focusing on health behaviors. Investigators have also made considerable strides in the diagnosis and treatment of depression among patients with CVD. At the same time, many research questions remain. In what settings is depression screening most effective for patients with CVD? What is the optimal screening frequency? Which therapies are safe and effective? How can we better integrate the care of mental health conditions with that of CVD? How do we motivate depressed patients to change health behaviors? What technological tools can we use to improve care for depression? Gaining a more thorough understanding of the links between MDD and heart disease, and how best to diagnose and treat depression among these patients, has the potential to substantially reduce morbidity and mortality from CVD. Published by Elsevier Inc.

  6. Cardiovascular and interventional radiology

    International Nuclear Information System (INIS)

    White, R.I. Jr.

    1985-01-01

    A symposium of eight short but complete papers giving an overview of interventional radiology is presented. Organized by Dr. William Casarella, this symposium is certainly the most current review of the subject available. This year's cardiovascular section is again heavily weighted toward interventional radiology. Abrams and Doubilet's article on the underutilization of angioplasty is important because it describes the cost effectiveness of this method. Most health planners, right or wrong, have complained about overutilization of diagnostic radiology procedures. In general, the opposite is true for interventional procedures - they are underutilized. If the authors draw the attention of their hospital administrators to these approaches and also produce the data on long-term follow-up for our medical colleagues, interventional radiology may realize its full potential. Articles on cardiac magnetic resonance imaging are beginning to appear and this technique seems to have great potential. An important article, which is the first prospective study comparing lung scintigraphy and pulmonary angiography in the diagnosis of pulmonary embolism, supports the increased use of pulmonary angiography. Finally, an article on complications of percutaneous biliary drainage provokes some discussion of its value for routine preoperative use

  7. Cardiovascular nuclear medicine and MRI

    International Nuclear Information System (INIS)

    Reiber, J.H.C.; Wall, E.E. van der

    1992-01-01

    This book is based on a meeting of the Working Group on Nuclear Cardiology, which held March 22-23,1991 under the auspices of the European Society of Cardiology and the Interuniversity Cardiology Institute of the Netherlands, and on the Second International Symposium on Computer Applications in Nuclear Medicine and Cardiac Magnetic Resonance Imaging, which was held March 20-22,1991 in Rotterdam, the Netherlands. It covers almost every aspect of quantitative cardio-vascular nuclear medicine and magnetic resonance imaging. The main topics are: single photon emission computed tomography (technical aspects); new development in cardiovascular nuclear medicine; advances in cardiovascular imaging; cardiovascular clinical applications; and cardiac magnetic resonance imaging. (A.S.). refs.; figs.; tabs

  8. Cardiovascular autonomic neuropathy in diabetes

    DEFF Research Database (Denmark)

    Spallone, Vincenza; Ziegler, Dan; Freeman, Roy

    2011-01-01

    Cardiovascular Autonomic Neuropathy (CAN) Subcommittee of Toronto Consensus Panel on Diabetic Neuropathy worked to update CAN guidelines, with regard to epidemiology, clinical impact, diagnosis, usefulness of CAN testing, and management. CAN is the impairment of cardiovascular autonomic control...... in type 2 diabetes. CAN is a risk marker of mortality and cardiovascular morbidity, and possibly a progression promoter of diabetic nephropathy. Criteria for CAN diagnosis and staging are: 1. one abnormal cardio-vagal test identifies possible or early CAN; 2. at least two abnormal cardio-vagal tests....... diagnosis of CAN clinical forms, 2. detection and tailored treatment of CAN clinical correlates (e.g. tachycardia, OH, nondipping, QT interval prolongation), 3. risk stratification for diabetic complications and cardiovascular morbidity and mortality, and 4. modulation of targets of diabetes therapy...

  9. Sex differences in cardiovascular function

    Czech Academy of Sciences Publication Activity Database

    Kolář, František; Ošťádal, Bohuslav

    2013-01-01

    Roč. 207, č. 4 (2013), s. 584-587 ISSN 1748-1708 Institutional support: RVO:67985823 Keywords : heart * vascular * risk factors * sex Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 4.251, year: 2013

  10. Cardiovascular risk in Turner syndrome.

    Science.gov (United States)

    Donato, Beatriz; Ferreira, Maria João

    2018-06-01

    Turner syndrome is a relatively common genetic disorder of female development, characterized by partial or complete absence of an X chromosome, with a variable clinical presentation. Congenital or acquired cardiovascular disease is highly prevalent and a major cause of early death in this syndrome. The most feared complication is aortic dissection, which can occur at a very young age and requires careful assessment of its risk factors. A systematic literature search identified sixty relevant publications. These were reviewed with regard to the increased risk of cardiovascular disease in women with Turner syndrome, especially in pregnancy. The most common congenital cardiovascular defects are presented and illustrated with appropriate iconography. The current recommendations regarding the screening and monitoring of cardiovascular disease in these patients are discussed. Copyright © 2018 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Genetic risks for cardiovascular diseases

    NARCIS (Netherlands)

    Zafarmand, M.H.

    2008-01-01

    Atherosclerotic cardiovascular disease (CVD), which involves the heart, brain, and peripheral circulation, is a major health problem world-wide. The development of atherosclerosis is a complex process, and several established risk factors are involved. Nevertheless, these established risk factors

  12. Cardiovascular adaptations to exercise training

    DEFF Research Database (Denmark)

    Hellsten, Ylva; Nyberg, Michael

    2016-01-01

    Aerobic exercise training leads to cardiovascular changes that markedly increase aerobic power and lead to improved endurance performance. The functionally most important adaptation is the improvement in maximal cardiac output which is the result of an enlargement in cardiac dimension, improved...... and peripheral cardiovascular adaptations with a focus on humans, but also covers animal data. © 2016 American Physiological Society. Compr Physiol 6:1-32, 2016....

  13. Copa do mundo de futebol como desencadeador de eventos cardiovasculares World soccer cup as a trigger of cardiovascular events

    Directory of Open Access Journals (Sweden)

    Daniel Guilherme Suzuki Borges

    2013-01-01

    Full Text Available FUNDAMENTO: Síndromes coronarianas agudas são a maior causa de mortalidade no mundo. Estímulos externos, também conhecidos como gatilhos, como estado emocional ou atividade física, podem produzir mudanças fisiopatológicas desencadeantes. Dentre os gatilhos estudados, eventos estressantes, como campeonatos de futebol, são controversos na literatura e não há dados efetivos para a população brasileira. OBJETIVO: Avaliar os efeitos agudos do estresse ambiental induzido pelos jogos da Copa do Mundo de Futebol no aumento da incidência de doenças cardiovasculares no Brasil. MÉTODOS: Foram obtidos dados publicamente disponíveis do Sistema Único de Saúde referentes às internações hospitalares com código internacional de doenças, referentes às síndromes isquêmicas agudas, no período de maio a agosto de 1998 a 2010 (155.992 internações. Restringiu-se a análise aos pacientes maiores que 35 anos e internados por especialidades clínicas. Comparou-se a incidência de infarto e óbito entre os dias sem copa (Grupo I: 144.166; 61,7 ± 12,3 anos; 59,4%masculino, dias de copa sem jogos do Brasil (Grupo II: 9.768; 61,8 ± 12,3 anos; 60,0% masculino e dias de jogos do Brasil (Grupo III: 2.058; 61,6 ± 12,6 anos; 57,8% masculino. Utilizou-se regressão logística e de Poisson para ajustar por idade, gênero, densidade populacional e número de postos de atendimento. RESULTADOS: Houve aumento da incidência de infarto para jogos de copa do mundo (1,09; IC95% = 1,05-1,15 e do Brasil (1,16; IC95% = 1,06-1,27. Não houve impacto sobre mortalidade - copa (1,00; IC95% = 0,93-1,08 e Brasil (1,04; IC95% = 0,93-1,22. CONCLUSÃO: A copa do mundo e, especialmente, os jogos da seleção brasileira implicam maior incidência de infarto agudo do miocárdio, mas não de mortalidade intra-hospitalar.BACKGROUND: Acute coronary syndromes are the major cause of death in Brazil and in the world. External stimuli, known also as triggers, such as emotional

  14. Environmental Factors and Cardiovascular Diseases

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    Omer Faruk Tekbas

    2008-10-01

    Full Text Available Epidemiological and clinical observations have led to the hypothesis that the risk of developing cardiovascular diseases is influenced not only by genetic, lifestyle and major risk factors, but also by environmental factors. Environmental factors are considered key determinants of cardiovascular diseases. Although lifestyle choices such as smoking, diet, and exercise are viewed as major environmental influences, the contribution of pollutants and environmental chemicals is less clear. Accumulating evidence suggests that exposure to physically and chemical pollutants could elevate the risk of cardiovascular diseases. Many epidemiological studies report that exposure to physically, biologically and socio-cultural environmental factors are associated with an increase in cardiovascular mortality. Relationships between environmental factors and coronary arter disease, arhythmias, and cardiomyopathies have been reported. Exposures to arsenic, lead, cadmium, pollutant gases, solvents, and pesticides have also been linked to increased incidence of cardiovascular disease. In this paper, I review that relationships between exposure to physically, chemical, biologically and socio-cultural environmental factors and cardiovascular diseases. [TAF Prev Med Bull 2008; 7(5.000: 435-444

  15. Eventos cardiovasculares en una población cerrada. Seguimiento a 10 años

    Directory of Open Access Journals (Sweden)

    Leandro M. Goldstraj

    2008-01-01

    Full Text Available IntroducciónEn estudios epidemiológicos previos se observó que poblaciones con igual riesgo por suma de factores clásicos poseían una incidencia y tipos de expresión de enfermedades cardiovasculares diferentes.ObjetivoDeterminar la incidencia de MACE, compuesta por infarto agudo de miocardio, angina inestable, accidente cerebrovascular, angioplastia transluminal coronaria, cirugía de revascularización miocárdica o muerte cardiovascular, y su asociación con los factores de riesgo en una población cerrada. Material y métodosEl presente es un estudio de cohorte prospectivo en el que fueron relevados hombres, de profesión policías, durante el año 1997. Luego se ingresaron en la base de datos hospitalaria aquellos que presentaron eventos en los 10 años posteriores. Se empleó la prueba de la t de Student para variables cuantitativas y regresión logística para las cualitativas. ResultadosSe incluyeron 2.379 personas de sexo masculino. La edad promedio fue de 39,5 ± 9,25 años. La prevalencia de factores de riesgo conocidos por las personas fue: HTA 11,1%, dislipidemia 20,3%, diabetes 2,4%, tabaquismo 43,3%. Noventa pacientes presentaron algún tipo de MACE. El odds ratio para diabetes fue 4,54 (IC 95% 2,1-9,81, HTA 2,3 (IC 95% 1,38-3,85, dislipidemia 2,74 (IC 95% 1,77-4,25 y para tabaquismo 1,48 (IC 95% 0,97-2,28. La edad, el LDL, el fibrinógeno y las horas trabajo diarias mostraron asociaciones significativas. El área bajo la curva ROC del puntaje de Framingham fue de 0,72 y para el puntaje europeo fue de 0,71. ConclusiónLos factores de riesgo de enfermedad cardiovascular clásicos tuvieron una importancia similar a los ya comunicados por los estudios epidemiológicos; es importante destacar algunos no clásicos como el fibrinógeno. Los puntajes de riesgo fueron predictores regulares en esta población. Las características especiales de la población analizada permiten la ejecución de programas de prevención acordes.

  16. Ceruloplasmin and cardiovascular disease

    Science.gov (United States)

    Fox, P. L.; Mazumder, B.; Ehrenwald, E.; Mukhopadhyay, C. K.

    2000-01-01

    Transition metal ion-mediated oxidation is a commonly used model system for studies of the chemical, structural, and functional modifications of low-density lipoprotein (LDL). The physiological relevance of studies using free metal ions is unclear and has led to an exploration of free metal ion-independent mechanisms of oxidation. We and others have investigated the role of human ceruloplasmin (Cp) in oxidative processes because it the principal copper-containing protein in serum. There is an abundance of epidemiological data that suggests that serum Cp may be an important risk factor predicting myocardial infarction and cardiovascular disease. Biochemical studies have shown that Cp is a potent catalyst of LDL oxidation in vitro. The pro-oxidant activity of Cp requires an intact structure, and a single copper atom at the surface of the protein, near His(426), is required for LDL oxidation. Under conditions where inhibitory protein (such as albumin) is present, LDL oxidation by Cp is optimal in the presence of superoxide, which reduces the surface copper atom of Cp. Cultured vascular endothelial and smooth muscle cells also oxidize LDL in the presence of Cp. Superoxide release by these cells is a critical factor regulating the rate of oxidation. Cultured monocytic cells, when activated by zymosan, can oxidize LDL, but these cells are unique in their secretion of Cp. Inhibitor studies using Cp-specific antibodies and antisense oligonucleotides show that Cp is a major contributor to LDL oxidation by these cells. The role of Cp in lipoprotein oxidation and atherosclerotic lesion progression in vivo has not been directly assessed and is an important area for future studies.

  17. Obesity and Cardiovascular Disease.

    Science.gov (United States)

    Ortega, Francisco B; Lavie, Carl J; Blair, Steven N

    2016-05-27

    The prevalence of obesity has increased worldwide over the past few decades. In 2013, the prevalence of obesity exceeded the 50% of the adult population in some countries from Oceania, North Africa, and Middle East. Lower but still alarmingly high prevalence was observed in North America (≈30%) and in Western Europe (≈20%). These figures are of serious concern because of the strong link between obesity and disease. In the present review, we summarize the current evidence on the relationship of obesity with cardiovascular disease (CVD), discussing how both the degree and the duration of obesity affect CVD. Although in the general population, obesity and, especially, severe obesity are consistently and strongly related with higher risk of CVD incidence and mortality, the one-size-fits-all approach should not be used with obesity. There are relevant factors largely affecting the CVD prognosis of obese individuals. In this context, we thoroughly discuss important concepts such as the fat-but-fit paradigm, the metabolically healthy but obese (MHO) phenotype and the obesity paradox in patients with CVD. About the MHO phenotype and its CVD prognosis, available data have provided mixed findings, what could be partially because of the adjustment or not for key confounders such as cardiorespiratory fitness, and to the lack of consensus on the MHO definition. In the present review, we propose a scientifically based harmonized definition of MHO, which will hopefully contribute to more comparable data in the future and a better understanding on the MHO subgroup and its CVD prognosis. © 2016 American Heart Association, Inc.

  18. Edema agudo do pulmão pós-extubação traqueal – Caso clínico

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    Maria de Lurdes Castro

    2009-05-01

    Full Text Available Resumo: O edema agudo do pulmão pós-extubação traqueal é um acontecimento raro (≈ 0,1%1. A etiologia é multifactorial, sendo a obstrução da via aérea superior o factor desencadeante principal. O esforço inspiratório contra a glote encerrada causa pressões intratorácicas muito negativas, que se transmitem ao interstício pul-monar, condicionando uma transudação de fluidos a partir dos vasos capilares pulmonares1−5. Relatamos um caso de edema agudo do pulmão pós-extubação num doente de quinze anos, operado no serviço de urgência por amputação traumática da perna esquer-da. Revemos a fisiopatologia, o padrão radiológico, potenciais factores de risco e medidas preventivas des-ta complicação respiratória pós-anestésica.Rev Port Pneumol 2009; XV (3: 537-541 Abstract: Negative pressure pulmonary oedema is an uncommon complication of traqueal extubation (≈ 0,1% mostly caused by acute upper airway obstruction. Upper airway obstruction from glottis closure leads to marked inspiratory effort, which generates negative intrathoracic pressure transmitting to pulmonary interstitium, and inducing fluid transudation from pulmonary capillary bed1−5. We report a case of post-extubation pulmonary oedema in a fifteen years old patient, submitted to surgery following traumatic amputation of his left leg. We review the pathophysiology, radiological findings, potential risk factors and preventive measures of this post-anaesthetic respiratory complication.Rev Port Pneumol 2009; XV (3: 537-541 Palavras-chave: Edema agudo do pulmão pós-extubação traqueal, obstrução da via aérea superior, laringospasmo, pressão negativa intratorácica, Key-words: Post-extubation pulmonary oedema, upper airway obstruction, laryngospasm, intra-thoracic negative pressure

  19. Vivendo o acidente vascular encefálico agudo: significados da doença para pessoas hospitalizadas Viviendo el accidente cerebrovascular agudo: significado de la enfermedad para personas hospitalizadas Experiencing acute stroke: the meaning of the illness for hospitalized patients

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    Samia Jardelle Costa de Freitas Maniva

    2013-04-01

    Full Text Available Objetivou-se compreender o significado da experiência vivenciada pela pessoa adoecida por acidente vascular encefálico agudo. Trata-se de estudo qualitativo, fundamentado nos pressupostos teóricos do interacionismo simbólico, realizado em uma unidade especializada no tratamento de acidente vascular encefálico de um hospital terciário, situado na cidade de Fortaleza, CE. Participaram do estudo 10 pacientes. A coleta de dados ocorreu por meio de entrevista aberta e os dados foram organizados e analisados segundo a técnica de enunciação. Cumpriram-se todos os aspectos éticos. O significado da experiência de adoecimento foi construído com base na percepção dos sentimentos surgidos durante a hospitalização, caracterizados por medo da morte e das sequelas da doença; tristeza pelo distanciamento do lar; alívio, ao evidenciar-se melhora do quadro clínico, e desejo de mudança dos hábitos de vida. Apreendeu-se que a experiência de adoecimento por acidente vascular encefálico é complexa, e nela os significados são elaborados com base em sentimentos, ações e comportamentos dos sujeitos.Se objetivó comprender el significado de la experiencia de la persona que padeció accidente cerebrovascular agudo. Estudio cualitativo, fundamentado en los presupuestos teóricos del interaccionismo simbólico, realizado en unidad especializada en tratamiento de accidente cerebrovascular de un hospital terciario en Fortaleza-CE. Participaron diez pacientes. Datos recolectados mediante entrevista abierta, organizados y analizados según técnica de enunciación. Se cumplió con todos los aspectos éticos. El significado de la experiencia del padecimiento fue construido en base a la percepción de los sentimientos surgidos durante la internación, caracterizados por el miedo a la muerte y a las secuelas de la enfermedad; tristeza por alejarse del hogar; alivio al evidenciarse mejoras del cuadro clínico; e intención de cambio de hábitos de vida

  20. Mobilization and early hospital discharge for patients with acute myocardial infarction: literature review Movilización y alta precoz en pacientes con infarto agudo del miocardio: revisión de lieratura Mobilização e alta precoce em pacientes com infarto agudo do miocárdio: revisão de literatura

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    Juliana de Lima Lopes

    2008-01-01

    Full Text Available OBJECTIVE: This study was a literature review with the purpose of analyzing articles comparing early and late mobilization and those comparing early and late discharge for patients with acute myocardial infarction. METHODS: The literature review was performed using the Lilacs and Medline databases (1966-2007, and the length of the resting period, the hospitalization and possible complications were analyzed. RESULTS: We selected 18 articles; 11 of them compared early and late mobilization and 7 compared early and late discharge. The length of the resting period in the early mobilization group varied from 2 to 10 days and 5 to 28 days for the longest resting period. The early discharge group stayed in the hospital from 3 to 14 days and the late discharge group stayed in the hospital from 5 to 21 days. CONCLUSION: The studies show that there is no evidence of complications related to short periods of bed rest and hospitalization.OBJETIVO: Analizar los artículos que comparaban la movilización precoz con la tardía, así como aquellos que comparaban el alta precoz con la tardía en pacientes con infarto agudo del miocardio. MÉTODOS: La revisión bibliográfica fue realizada en las Bases de Datos Lilacs y Medline, y fueron analizados el tiempo de reposo y de hospitalización y las complicaciones observadas en los estudios. RESULTADOS: Fueron seleccionados 18 artículos, difundidos entre 1996 y 2007, de los cuales 11 comparaban la movilización precoz con la tardía y 7 el alta precoz con la tardía. El período de reposo en la cama para la movilización precoz varió de 2 a 10 días y de 5 a 28 días para la movilización tardía. Con relación al tiempo de hospitalización se observó que el período de alta precoz varió de 3 a 14 días y de 5 a 21 días para el alta tardía. CONCLUSIÓN: Los estudios muestran que no hay evidencias de mayores complicaciones relacionadas a los cortos períodos de reposo y de hospitalización.OBJETIVO: Analisar os

  1. Os significados da palavra conforto segundo a perspectiva do paciente com infarto agudo do miocárdio Los significados de la palabra bienestar según la perspectiva del paciente con infarto agudo del miocardio The meaning of the word comfort from the point of view of patients with acute myocardial infarction

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    Fernanda Carneiro Mussi

    1996-12-01

    Full Text Available O estudo objetivou identificar o significado da palavra conforto conferido por pacientes com infarto agudo do miocárdio, do sexo masculino, internados numa Unidade Coronariana do município de São Paulo. A coleta de dados foi realizada por meio de formulário específico. As respostas às questões abertas foram tratadas utilizando-se o método de análise de conteúdo de BARDIN², e os resultados basicamente analisados sob a forma de números absolutos percentuais. O conforto enquanto significado foi expressado com vários sentidos, relacionando-se com as condições materiais ou financeiras (29,4%, o desfrutar das interações pessoais (21,6%, as sensações de bem-estar psicológico (13,7%, físico (11,8% e espiritual (9,8%, o funcionar normalmente (13,7%, isto é, Ter expectativas de recuperação, estar livre de doenças e poder desempenhar as atividades habituais.El objetivo del estudio fue identificar cuál es el significado que los pacientes de sexo masculino diagnosticado con infarto agudo del miocardio, internados en una unidad coronaria del municipio de São Paulo, le dan a la palabra bienestar. La fuente de los datos fue obtenida por medio de un formulario específico. Las respuestas a las preguntas abiertas fueron tratadas utilizándose en método de análisis de contenido de BARDIN² y los resultados básicamente analizados sobre la forma de números absolutos y porcentuales. En cuanto el significado de bienestar fue expresado con varios sentidos, relacionándose con las condiciones materiales o financieras (29,4%, el disfrute de las interacciones personales (21,6% las sensaciones del bienestar psicológico (13,7%, físico (11,8% y espiritual (9,8%, el funcionar normalmente (13,7% esto es, tener expectativa de recuperación, estar libre de enfermedad y poder desempeñar las actividades habituales. Además de las conclusiones relacionadas directamente a los objetivos, los resultados del presente estudio permiten decir también: a

  2. Perda da espontaneidade da ação: o desconforto de homens que sofreram infarto agudo do miocardio Perdida de la expontaneidad de la accion: el desconforto de hombres que sufrieron infarto agudo del miocardio Undergoing loss of spontaneous action: the discomfort experienced by men having suffered acute myocardial infarction

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    Fernanda Carneiro Mussi

    2002-06-01

    Full Text Available Considerando que conforto - cuja promoção é uma das metas centrais da enfermagem -- e desconforto devem ser entendidos àluz das interações vivenciadas pelo paciente - e, portanto, vinculadas aos fatores objetivos das instituições, da nacionalidade epráticas que as fundamentam - este estudo investigou os significados de conforto e desconforto na perspectiva de homens quesofreram infarto agudo do miocárdio (IAM. Recorrendo ao Interacionismo Simbólico eàmetodologia da Teoria Fundamentadanos Dados, entrevistas foram feitas com 13 homens que sofreram IAM, em duas unidades de saúde na cidade de São Paulo. Aanálise permitiu construir um modelo teórico daqueles significados nessa experiência, caracterizada por três fenômenos eessencialmente permeada pelo desconforto de "padecer a perda da espontaneidade daação ".Este artigo resume o processopsicossocial básico da experiência, discutindo suas implicações para questionar o modelo clínico de intervenção, apontando apossibilidade de a enfermagem atuar na prevenção e propondo questões para aprimorar a formação do enfermeiro.Considerando que conforto - cuya promoción es una de las metas centralés de la enfermeria - y desconforto deven ser entendidos a la luz de las interacciones vivenciadas por el paciente e por lo tanto, vinculadas a los factores objetivos de las instituciones, dela racionalidad y de las prácticas que las fundamentan - este estudio investigo los significados de conforto e desconforto en la prespectiva de hombres que sufrieron infarto agudo del miocardio (IAM. Acudiendo al Interaccionismo SimbólicoYala meto-dologia de la Teoria Fudamentada en los datos, fueron realizadas entrevistas com 13 hombres que sufrieron IAM en dos unida-des de salud en la cuidad de São Paulo. El análisis permitio construir um modelo teórico de aquellos significados en esa experi-encia, caracterizada por tres fenómenos y esencialmente condicionada por el desconforto de "padecer

  3. Cardiovascular risk and subclinical cardiovascular disease in polycystic ovary syndrome.

    Science.gov (United States)

    Bajuk Studen, Katica; Jensterle Sever, Mojca; Pfeifer, Marija

    2013-01-01

    In addition to its effects on reproductive health, it is now well recognized that polycystic ovary syndrome (PCOS) is a metabolic disorder, characterized by decreased insulin sensitivity which leads to an excess lifetime risk of type 2 diabetes and cardiovascular disease. PCOS patients are often obese, hypertensive, dyslipidemic and insulin resistant; they have obstructive sleep apnea and have been reported to have higher aldosterone levels in comparison to normal healthy controls. These are all components of an adverse cardiovascular risk profile. Many studies exploring subclinical atherosclerosis using different methods (flow-mediated dilatation, intima media thickness, arterial stiffness, coronary artery calcification) as well as assessing circulating cardiovascular risk markers, point toward an increased cardiovascular risk and early atherogenesis in PCOS. The risk and early features of subclinical atherosclerosis can be reversed by non-medical (normalization of weight, healthy lifestyle) and medical (metformin, thiazolidinediones, spironolactone, and statins) interventions. However, the long-term risk for cardiovascular morbidity and mortality as well as the clinical significance of different interventions still need to be properly addressed in a large prospective study. Copyright © 2013 S. Karger AG, Basel.

  4. Lesão bilateral dos óstios coronários na sífilis cardiovascular: relato de caso Bilateral ostial coronary lesion in cardiovascular syphilis: case report

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    Mauricio de Nassau Machado

    2008-03-01

    Full Text Available A sífilis é uma doença infecciosa que se desenvolve em estágios e pode acometer o sistema cardiovascular e neurológico. Em 30% dos pacientes não tratados, a sífilis desenvolve sua forma terciária. Relatamos o caso de um homem de 46 anos, admitido por edema pulmonar agudo por cardiopatia isquêmica com bloqueio completo do ramo esquerdo, submetido a terapia fibrinolítica com sucesso. Angiografia coronária mostrou lesão ostial de 90% na artéria coronária esquerda e oclusão do óstio da artéria coronária direita. Os títulos de VDRL foram de 1/128. O paciente foi submetido a revascularização do miocárdio e recebeu alta após tratamento antibiótico com penicilina cristalina.Syphilis is an infectious disease occurring through a series of frequently overlapping stages. It can impair the cardiovascular and neurological system. In 30% of the non treated patients, syphilis develops your tertiary form. We report a case of a 46-year-old male patient admitted due to edema pulmonary and acute coronary syndrome with left bundle branch block, submitted to fibrinolytic therapy successfully. Coronary angiography showed a 90% ostial lesion of left main coronary artery and occlusion of the right coronary artery ostium. VDRL was titrated to 1/128. The patient was undergone to CABG and was discharged after treatment with crystalline penicillin.

  5. Gender bias in cardiovascular advertisements.

    Science.gov (United States)

    Ahmed, Sofia B; Grace, Sherry L; Stelfox, Henry Thomas; Tomlinson, George; Cheung, Angela M

    2004-11-01

    Women with cardiovascular disease are treated less aggressively than men. The reasons for this disparity are unclear. Pharmaceutical advertisements may influence physician practices and patient care. To determine if female and male patients are equally likely to be featured in cardiovascular advertisements. We examined all cardiovascular advertisements from US editions of general medical and cardiovascular journals published between 1 January 1996 and 30 June 1998. For each unique advertisement, we recorded the total number of journal appearances and the number of appearances in journals' premium positions. We noted the gender, age, race and role of both the primary figure and the majority of people featured in the advertisement. Nine hundred and nineteen unique cardiovascular advertisements were identified of which 254 depicted a patient as the primary figure. A total of 20%[95% confidence interval (CI) 15.3-25.5%] of these advertisements portrayed a female patient, while 80% (95% CI 74.5-84.7%) depicted a male patient, P advertisements appeared 249 times (13.3%; 95% CI 8.6-18.9%) while male patient advertisements appeared 1618 times (86.7%; 95% CI 81.1-91.4%), P advertisements also had significantly fewer mean appearances than male patient advertisements in journals' premium positions (0.82 vs. 1.99, P=0.02). Similar results were seen when the advertisements were analysed according to predominant gender. Despite increasing emphasis on cardiovascular disease in women, significant under-representation of female patients exists in cardiovascular advertisements. Physicians should be cognizant of this gender bias.

  6. O manejo da síndrome do desconforto respiratório agudo Management of the acute respiratory distress syndrome

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    Alexandre Tellechea Rotta

    2003-11-01

    Full Text Available OBJETIVO: Revisar as atuais estratégias de suporte e de tratamento da síndrome do desconforto respiratório agudo (SDRA. FONTE DOS DADOS: Dados próprios de nosso laboratório de pesquisa e bibliografia relacionada às áreas de SDRA e lesão pulmonar aguda, pesquisados através do Medline. SÍNTESE DOS DADOS: Apesar de avanços no entendimento da sua patogênese, a SDRA ainda resulta em significativa morbidade e mortalidade. A ventilação mecânica é a principal modalidade terapêutica na SDRA, sendo atualmente considerada não mais apenas uma medida de suporte, mas sim uma terapia capaz de alterar o curso da patologia. Novas estratégias ventilatórias, como a ventilação oscilatória de alta freqüência (VOAF, têm-se mostrado promissoras. Neste texto, revisamos o conhecimento atual no manejo da SDRA, incluindo ventilação mecânica convencional e não convencional, uso de surfactante, óxido nítrico, moduladores do processo inflamatório, oxigenação extracorpórea e posição prona. CONCLUSÕES: A última década foi marcada por avanços significativos, como o conceito de ventilação mecânica protetora na SDRA. O benefício da aplicação de estratégias alternativas, como a VOAF, assim como do uso do surfactante exógeno e moduladores de inflamação continuam sendo alvo de estudo.OBJECTIVE: To review the current support and treatment strategies of the Acute Respiratory Distress Syndrome (ARDS DATA SOURCES: Original data from our research laboratory and from representative scientific articles on ARDS and acute lung Injury searched through Medline. SUMMARY OF THE FINDINGS: Despite advances in the understanding of the pathogenesis of ARDS, this syndrome still results in significant morbidity and mortality. Mechanical ventilation, the main therapeutic modality for ARDS, is no longer considered simply a support modality, but a therapy capable of influencing the course of the disease. New ventilation strategies, such as high

  7. Síndrome do desconforto respiratório agudo pulmonar e extrapulmonar: existem diferenças? Pulmonary and extrapulmonary acute respiratory distress syndrome: are they different?

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    Cristiane S. N. Baez Garcia

    2008-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A patogênese da síndrome do desconforto respiratório agudo (SDRA tem sido explicada pela presença de uma agressão direta (SDRA pulmonar e/ou indireta (SDRA extrapulmonar ao parênquima pulmonar. Evidências indicam que a fisiopatologia da doença pode diferir com o tipo de lesão. O objetivo deste estudo foi apresentar breve revisão das diferenças entre a SDRA pulmonar e a SDRA extrapulmonar e discutir as interações entre os aspectos morfofuncionais e a resposta aos diferentes tratamentos. CONTEÚDO: Esta revisão bibliográfica baseou-se em uma pesquisa sistemática de artigos experimentais e clínicos sobre SDRA incluídos nas bases de dados MedLine e SciElo nos últimos 20 anos. Muitos pesquisadores concordam, com base em estudos experimentais, que a SDRA pulmonar e a SDRA extrapulmonar não são idênticas no que diz respeito aos aspectos morfofuncionais, a resposta à pressão positiva ao final da expiração (PEEP, manobra de recrutamento alveolar, posição prona e outras terapias farmacológicas. Entretanto, os estudos clínicos têm descrito resultados contraditórios, os quais podem ser atribuídos à dificuldade de se classificar a SDRA em uma ou outra etiologia, e de se precisar o início, a fase e a gravidade da SDRA nos pacientes. CONCLUSÕES: Pacientes com SDRA de etiologias distintas perduram sendo considerados como pertencendo a uma mesma síndrome e, assim, são tratados da mesma forma. Logo, é fundamental entender as diferenças fisiopatológicas entre a SDRA pulmonar e extrapulmonar para que a terapia seja mais bem direcionada.BACKGROUND AND OBJECTIVES: The pathogenesis of acute respiratory distress syndrome (ARDS has been described by the presence of direct (pulmonary and/or indirect (extrapulmonary insult to the lung parenchyma. Evidence indicates that the pathophysiology of ARDS may differ according to the type of primary insult. This article presents a brief overview of differences

  8. Comportamiento del fallo renal agudo en niños con sepsis grave Behavior of acute renal failure in children presenting with severe sepsis

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    María del Carmen Saura Hernández

    2010-03-01

    Full Text Available INTRODUCCIÓN. El objetivo de esta investigación fue determinar los factores de riesgo asociados al fallo renal agudo (FRA en un grupo de niños con sepsis grave atendidos entre enero del 2004 y diciembre del 2008. MÉTODOS. Se realizó un estudio observacional y analítico con una muestra de 171 pacientes. Se constituyeron dos grupos: el de estudio, integrado por 38 pacientes con estado de choque séptico o disfunción múltiple de órganos (DMO y FRA, y un grupo control, conformado por 133 niños en igual estadio de sepsis pero con función renal normal. Se revisaron las historias clínicas y se tuvieron en cuenta variables epidemiológicas, factores de riesgo de FRA y evolución de los casos. RESULTADOS. La incidencia de FRA fue del 22,2 %, y aunque disminuyó considerablemente en los 3 últimos años del estudio, la mortalidad fue del 42,1 %, mayoritariamente en el DMO (89,5 %. Se encontró dependencia entre la insuficiencia renal y la respuesta diurética no adecuada a la fluidoterapia (51,2 %, la inestabilidad hemodinámica por más de 24 h (46,5 %, la disfunción miocárdica (43,3 % y el uso de medicamentos nefrotóxicos (42,8 %. CONCLUSIONES. La respuesta diurética no adecuada a la fluidoterapia, la inestabilidad hemodinámica por más de 24 h, la disfunción miocárdica y el uso de medicamentos nefrotóxicos incrementan el riesgo de FRA en la sepsis grave, la cual duplica la mortalidad en relación con los pacientes que conservan la función renal. No obstante, la prevención de las formas graves de sepsis y un tratamiento adecuado de ésta disminuyen la incidencia de FRA.INTRODUCTION: The aim of present research was to determine the risk factor associated with the acute renal failure (ARF in a group of children with severe sepsis seen between January, 2004 and December, 2008. METHODS: An analytical and observational study was conducted in a sample including 171 patients. There were two groups: the study-group with 138 patients with

  9. Ejercicio y la detección del mal agudo de montaña grave Exercise and the detection of severe acute mountain sickness

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    Adrián Garófoli

    2010-02-01

    Full Text Available El mal agudo de montaña (MAM es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2.700 m y 4 300 m en 63 sujetos que ascendían al cerro Aconcagua (6 962 m. Se consideró desaturación de oxígeno con ejercicio a una disminución = 5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. Seis sujetos presentaron MAM grave (9.5% y requirieron evacuación. La saturación de oxígeno en reposo a 2.700 m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2.700 m más la saturación inapropiada en reposo a 4.300 m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave.Acute mountain sickness (AMS is a group of non-specific symptoms, seen in subjects that ascend from low to high altitude too quickly, without allowing sufficient time to acclimatize. Usually it is self-limiting, but the severe forms (pulmonary and cerebral edema can be fatal. Exaggerated hypoxemia at rest is related to later development of AMS but its predictive value is limited. Since exercise at altitude induces greater hypoxemia and

  10. Nefropatía por contraste en el síndrome coronario agudo Contrast induced nephropathy in acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Mariana Carnevalini

    2011-10-01

    Full Text Available La nefropatía inducida por contraste (NIC es una de las causas más frecuentes de insuficiencia renal en pacientes internados. En el síndrome coronario agudo (SCA, la presencia de NIC aumenta la morbimortalidad. Las medidas de profilaxis y los factores de riesgo intervinientes de NIC en SCA no han sido determinados con exactitud. El objetivo de este estudio fue evaluar la incidencia de NIC y los factores asociados a su desarrollo en pacientes ingresados en unidad coronaria con requerimiento de cinecoronariografía (CCG. Se realizó un estudio de cohorte retrospectivo. Se incluyeron pacientes consecutivos cursando SCA estudiados con CCG dentro de las 72 horas de su admisión. Se definió NIC al aumento del 25% del valor de creatinina a las 48 h sobre el nivel basal de ingreso. El período de inclusión fue entre el 1° de enero de 2004 hasta el 30 de junio de 2010. Se analizaron 125 casos. La incidencia de NIC fue del 10.4% (n = 13. En el análisis multivariado, los factores asociados independientemente a su desarrollo fueron la edad [OR 1.05 (IC 95% 1.004 - 1.11 p = 0.034], la angioplastia a múltiple vaso [OR 2.2 (IC 95% 1.07 - 4.8, p = 0.03] y el volumen de contraste utilizado [OR 1.007 (IC 95% 1.001 - 1.01, p = 0.014].Contrast induced nephropathy (CIN is one of the most frequent causes of acute renal failure in hospitalized patients. It is associated with an increase in morbidity and mortality in patients hospitalized for acute coronary syndrome (ACS undergoing percutaneous coronary intervention (PCI. Risk factors and prevention strategies are not well defined. The aim of this study was to assess the incidence and clinical risk factors associated to the development of contrast induced nephropathy in patients hospitalized for ACS. In a retrospective cohort we analyzed consecutive patients hospitalized for ACS undergoing urgent PCI within 72 hours from the admission. CIN was defined as a 25% increase of creatinine levels from baseline at 48

  11. Caracterización de la calidad de sedimentos afectados por vertidos de petróleo: comparación entre casos de vertidos accidentales (impacto agudo) frente a derrames continuos (impacto crónico)

    OpenAIRE

    Morales Caselles, Carmen

    2007-01-01

    La tesis presenta un estudio integral para carácterizar la calidad de sedimentos de dos áreas dél litoral españól afectadas por vertidos¿ de hidrocarburos. A finales del 2002 el accidente del petrolero monocasco Prestige provocó un vertido de 63000 toneladas de fuel oil pesado que se esparció en manchas, más o menos compactas y que supuso un impacto agudo de contaminación provocando una de las "mareas negras' más dañinas de las ocurridas en Galicia en los, últimos años Por-otra parte, la Babi...

  12. Efecto agudo del entrenamiento muscular excéntrico sobre la estabilidad del miembro inferior durante el aterrizaje después de caida desde diferentes alturas en jóvenes futbolistas de élite

    OpenAIRE

    Mateo Cortés, Jesús

    2013-01-01

    El objetivo principal de la presente investigación fue analizar el efecto agudo de una sesión de entrenamiento de fuerza con sobrecarga excéntrica sobre la estabilidad del miembro inferior tras aterrizaje después de caída desde altura de 30 cm y 50 cm. La muestra estuvo constituida por un total de dieciocho jugadores de fútbol (edad = 17 ± 1.2 años; altura = 178 ± 2,34 cm; peso = 71 ± 4.56 kg; IMC = 19.12 ± 2.45) pertenecientes a la cantera de un equipo profesional de fútbol de la liga españo...

  13. Síndrome do desconforto respiratório agudo relacionada à sepse em crianças com câncer: dinâmica respiratória de uma condição devastadora

    Directory of Open Access Journals (Sweden)

    Rodrigo Genaro Arduini

    Full Text Available RESUMO Objetivo: Avaliar a evolução clínica e os parâmetros respiratórios de crianças com câncer submetidas à ventilação mecânica que apresentavam síndrome do desconforto respiratório agudo relacionada à sepse. Métodos: Este estudo longitudinal, prospectivo e observacional de coorte com duração de 2 anos incluiu 29 crianças e adolescentes. Dados clínicos, avaliações de gasometria sanguínea e parâmetros ventilatórios foram coletados em quatro momentos diferentes. As flutuações entre as avaliações e as diferenças entre as médias estimadas foram analisadas por meio de modelos lineares mistos, tendo como parâmetro primário (endpoint a ocorrência de óbito dentro de 28 dias após o início da síndrome do desconforto respiratório agudo. Resultados: Ocorreram 17 óbitos dentro de 28 dias após o início da síndrome do desconforto respiratório agudo, e outros 7 entre 29 e 60 dias. Apenas cinco pacientes sobreviveram por mais de 60 dias. Nove (31% pacientes faleceram como consequência direta de hipoxemia refratária, e os demais em razão de falência de múltiplos órgãos e choque refratário a catecolaminas. Em 66% das avaliações, o volume corrente demandado para obter saturação de oxigênio igual ou acima de 90% foi superior a 7mL/kg. As médias estimadas de complacência dinâmica foram baixas e similares para sobreviventes e não sobreviventes, porém com inclinação negativa da reta entre a primeira e última avaliações, acompanhada por uma inclinação negativa da reta para volume corrente nos não sobreviventes. Os não sobreviventes tiveram significantemente mais hipoxemia, com relações PaO2/FiO2 que demonstravam médias mais baixas e inclinação negativa da reta nas quatro avaliações. As pressões pico, expiratória e média das vias aéreas demonstraram inclinações positivas na reta para os não sobreviventes, que também apresentaram mais acidose metabólica. Conclusões: Na maioria de

  14. Método de las invariantes en la conducta a seguir ante un paciente con abdomen agudo quirúrgico en el nivel primario de atención

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    Esteban Regalado García

    2003-08-01

    Full Text Available El médico que hoy formamos tiene una visión más integral de los problemas de salud del ser humano. En nuestro sistema de salud, el nivel primario constituye, en gran medida, su puerta de entrada. Los profesionales que laboran en este nivel deben estar preparados para resolver los problemas de salud propios de su especialidad e identificar aquellas entidades que deben ser resueltas en los otros niveles del sistema. El abdomen agudo quirúrgico es de los problemas de salud que deben ser atendidos oportunamente para evitar complicaciones, incluso fatales, en nuestros pacientes. Un método pedagógico para aprender los conocimientos necesarios, con calidad y que orienta la conducta correcta ante cada paciente, es el método de las invariantes. El concepto de invariante contempla la identificación de aquellas cuestiones fundamentales, esenciales y necesarias para poder sospechar un diagnóstico. Cuando el Médico General Integral conoce las invariantes de una entidad, puede tomar decisiones con un elevado margen de seguridad. Un abdomen agudo quirúrgico puede ser producido por cientos de enfermedades y estudiarlas una por una sería interminable; dada su gravedad, cualquier error que se cometa en su manejo puede ser fatal. Hemos identificado 7 signos invariantes en el abdomen agudo quirúrgico, estos signos que presentamos en este trabajo, pueden ser reconocidos en 9 de cada 10 pacientes que consultan con un dolor abdominal agudo. Existen dificultades para su identificación en un pequeño número de pacientes, a lo que hemos llamado "Situaciones Especiales".The physicians that we are preparing today have more comprehensive vision of the health problems of the human being. In our health care system, the primary health care level constitutes, in a greater extent, an entry door. Health professionals working at this level should be ready to solve health problems inherent to their specialty and to identify those entities that should be resolved at

  15. PPARs and the Cardiovascular System

    Science.gov (United States)

    Hamblin, Milton; Chang, Lin; Fan, Yanbo; Zhang, Jifeng

    2009-01-01

    Abstract Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone-receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of pharmacologic agents that induce hepatocyte peroxisome proliferation. PPARs also are expressed in cells of the cardiovascular system. PPARγ appears to be highly expressed during atherosclerotic lesion formation, suggesting that increased PPARγ expression may be a vascular compensatory response. Also, ligand-activated PPARγ decreases the inflammatory response in cardiovascular cells, particularly in endothelial cells. PPARα, similar to PPARγ, also has pleiotropic effects in the cardiovascular system, including antiinflammatory and antiatherosclerotic properties. PPARα activation inhibits vascular smooth muscle proinflammatory responses, attenuating the development of atherosclerosis. However, PPARδ overexpression may lead to elevated macrophage inflammation and atherosclerosis. Conversely, PPARδ ligands are shown to attenuate the pathogenesis of atherosclerosis by improving endothelial cell proliferation and survival while decreasing endothelial cell inflammation and vascular smooth muscle cell proliferation. Furthermore, the administration of PPAR ligands in the form of TZDs and fibrates has been disappointing in terms of markedly reducing cardiovascular events in the clinical setting. Therefore, a better understanding of PPAR-dependent and -independent signaling will provide the foundation for future research on the role of PPARs in human cardiovascular biology. Antioxid. Redox Signal. 11, 1415–1452. PMID:19061437

  16. Roadmap for cardiovascular circulation model

    Science.gov (United States)

    Bradley, Christopher P.; Suresh, Vinod; Mithraratne, Kumar; Muller, Alexandre; Ho, Harvey; Ladd, David; Hellevik, Leif R.; Omholt, Stig W.; Chase, J. Geoffrey; Müller, Lucas O.; Watanabe, Sansuke M.; Blanco, Pablo J.; de Bono, Bernard; Hunter, Peter J.

    2016-01-01

    Abstract Computational models of many aspects of the mammalian cardiovascular circulation have been developed. Indeed, along with orthopaedics, this area of physiology is one that has attracted much interest from engineers, presumably because the equations governing blood flow in the vascular system are well understood and can be solved with well‐established numerical techniques. Unfortunately, there have been only a few attempts to create a comprehensive public domain resource for cardiovascular researchers. In this paper we propose a roadmap for developing an open source cardiovascular circulation model. The model should be registered to the musculo‐skeletal system. The computational infrastructure for the cardiovascular model should provide for near real‐time computation of blood flow and pressure in all parts of the body. The model should deal with vascular beds in all tissues, and the computational infrastructure for the model should provide links into CellML models of cell function and tissue function. In this work we review the literature associated with 1D blood flow modelling in the cardiovascular system, discuss model encoding standards, software and a model repository. We then describe the coordinate systems used to define the vascular geometry, derive the equations and discuss the implementation of these coupled equations in the open source computational software OpenCMISS. Finally, some preliminary results are presented and plans outlined for the next steps in the development of the model, the computational software and the graphical user interface for accessing the model. PMID:27506597

  17. Cardiovascular Safety Pharmacology of Sibutramine.

    Science.gov (United States)

    Yun, Jaesuk; Chung, Eunyong; Choi, Ki Hwan; Cho, Dae Hyun; Song, Yun Jeong; Han, Kyoung Moon; Cha, Hey Jin; Shin, Ji Soon; Seong, Won-Keun; Kim, Young-Hoon; Kim, Hyung Soo

    2015-07-01

    Sibutramine is an anorectic that has been banned since 2010 due to cardiovascular safety issues. However, counterfeit drugs or slimming products that include sibutramine are still available in the market. It has been reported that illegal sibutramine-contained pharmaceutical products induce cardiovascular crisis. However, the mechanism underlying sibutramine-induced cardiovascular adverse effect has not been fully evaluated yet. In this study, we performed cardiovascular safety pharmacology studies of sibutramine systemically using by hERG channel inhibition, action potential duration, and telemetry assays. Sibutramine inhibited hERG channel current of HEK293 cells with an IC50 of 3.92 μM in patch clamp assay and increased the heart rate and blood pressure (76 Δbpm in heart rate and 51 ΔmmHg in blood pressure) in beagle dogs at a dose of 30 mg/kg (per oral), while it shortened action potential duration (at 10 μM and 30 μM, resulted in 15% and 29% decreases in APD50, and 9% and 17% decreases in APD90, respectively) in the Purkinje fibers of rabbits and had no effects on the QTc interval in beagle dogs. These results suggest that sibutramine has a considerable adverse effect on the cardiovascular system and may contribute to accurate drug safety regulation.

  18. The cardiovascular system after exercise

    Science.gov (United States)

    Romero, Steven A.; Minson, Christopher T.

    2017-01-01

    Recovery from exercise refers to the time period between the end of a bout of exercise and the subsequent return to a resting or recovered state. It also refers to specific physiological processes or states occurring after exercise that are distinct from the physiology of either the exercising or the resting states. In this context, recovery of the cardiovascular system after exercise occurs across a period of minutes to hours, during which many characteristics of the system, even how it is controlled, change over time. Some of these changes may be necessary for long-term adaptation to exercise training, yet some can lead to cardiovascular instability during recovery. Furthermore, some of these changes may provide insight into when the cardiovascular system has recovered from prior training and is physiologically ready for additional training stress. This review focuses on the most consistently observed hemodynamic adjustments and the underlying causes that drive cardiovascular recovery and will highlight how they differ following resistance and aerobic exercise. Primary emphasis will be placed on the hypotensive effect of aerobic and resistance exercise and associated mechanisms that have clinical relevance, but if left unchecked, can progress to symptomatic hypotension and syncope. Finally, we focus on the practical application of this information to strategies to maximize the benefits of cardiovascular recovery, or minimize the vulnerabilities of this state. We will explore appropriate field measures, and discuss to what extent these can guide an athlete’s training. PMID:28153943

  19. Cardiovascular Risk in Primary Hyperaldosteronism.

    Science.gov (United States)

    Prejbisz, A; Warchoł-Celińska, E; Lenders, J W M; Januszewicz, A

    2015-12-01

    After the first cases of primary aldosteronism were described and characterized by Conn, a substantial body of experimental and clinical evidence about the long-term effects of excess aldosterone on the cardiovascular system was gathered over the last 5 decades. The prevalence of primary aldosteronism varies considerably between different studies among hypertensive patients, depending on patient selection, the used diagnostic methods, and the severity of hypertension. Prevalence rates vary from 4.6 to 16.6% in those studies in which confirmatory tests to diagnose primary aldosteronism were used. There is also growing evidence indicating that prolonged exposure to elevated aldosterone concentrations is associated with target organ damage in the heart, kidney, and arterial wall, and high cardiovascular risk in patients with primary aldosteronism. Therefore, the aim of treatment should not be confined to BP normalization and hypokalemia correction, but rather should focus on restoring the deleterious effects of excess aldosterone on the cardiovascular system. Current evidence convincingly demonstrates that both surgical and medical treatment strategies beneficially affect cardiovascular outcomes and mortality in the long term. Further studies can be expected to provide better insight into the relationship between cardiovascular risk and complications and the genetic background of primary aldosteronism. © Georg Thieme Verlag KG Stuttgart · New York.

  20. Efecto de un tratamiento agudo con norgestomet en la dinámica folicular de vacas Cebú x Holstein sincronizadas con implantes de norgestomet y eCG

    Directory of Open Access Journals (Sweden)

    R. Páez

    2005-01-01

    Full Text Available El objetivo del presente estudio fue evaluar el efecto de una inyección de norgestomet en la dinámica folicular de vacas Cebú x Holstein sincronizadas con implantes de norgestomet. Se utilizaron 50 vacas en lactación con más de 60 días posparto, las cuales recibieron un implante de 3 mg de norgestomet y una dosis luteolítica de PGF2a (día cero. El día cinco, a 25 vacas (grupo Norg, se les administraron 1.8 mg de norgestomet intramuscular (IM y 25 vacas (grupo testigo, recibieron 3 ml de solución salina. El noveno día se retiró el implante, se realizó un destete temporal por 72 h y los animales fueron divididos al azar dentro de sus tratamientos para recibir (n = 23 o no (n = 27 500 UI de eCG. Posteriormente, las vacas fueron observadas durante cinco días en forma continua para la detección de signos de estro. Se realizaron diariamente ecografías de los ovarios desde el día de la inserción del implante hasta la presentación de estro. El tratamiento agudo con norgestomet provocó recambio del folículo dominante (FD en 40% (10/25 de las vacas, contra 16% (4/25 del grupo testigo (P 0.05 el porcentaje de vacas que presentaron estro ni el tiempo de presentación del mismo. Se concluye que el tratamiento agudo con norgestomet, durante la sincronización del estro con progestágenos, provoca atresia y recambio folicular. Sin embargo, este efecto depende de la etapa de desarrollo del folículo dominante al momento del tratamiento.

  1. Edema agudo do pulmão pós-extubação traqueal - Caso clínico Post-tracheal extubation pulmonary oedema - Case report

    Directory of Open Access Journals (Sweden)

    Maria de Lurdes Castro

    2009-05-01

    Full Text Available O edema agudo do pulmão pós-extubação traqueal é um acontecimento raro (≈ 0,1%¹. A etiologia e multifactorial, sendo a obstrução da via aérea superior o factor desencadeante principal. O esforço inspiratório contra a glote encerrada causa pressões intratorácicas muito negativas, que se transmitem ao interstício pulmonar, condicionando uma transudação de fluidos a partir dos vasos capilares pulmonares1-5. Relatamos um caso de edema agudo do pulmão pós-extubação num doente de quinze anos, operado no serviço de urgência por amputação traumática da perna esquerda. Revemos a fisiopatologia, o padrão radiológico, potenciais factores de risco e medidas preventivas desta complicação respiratória pós-anestésica.Negative pressure pulmonary oedema is an uncommon complication of traqueal extubation (≈ 0,1%¹ mostly caused by acute upper airway obs truction. Upper airway obstruction from glottis closure leads to marked inspiratory effort, which generates negative intrathoracic pressure transmitting to pulmonary interstitium, and inducing fluid transudation from pulmonary capillary bed1-5. We report a case of post-extubation pulmonary oedema in a fifteen years old patient, submitted to surgery following traumatic amputation of his left leg. We review the pathophysiology, radiological findings, potential risk factors and preventive measures of this post-anaesthetic respiratory complication.

  2. Comportamiento del infarto agudo del miocardio en personas con diabetes mellitus de la provincia Granma Situation of the acute myocardial infarction in persons with diabetes mellitus in Granma province

    Directory of Open Access Journals (Sweden)

    Eduardo René Valdés Ramos

    2012-08-01

    Full Text Available Antecedentes: la diabetes mellitus, además de ser un factor de riesgo para el infarto agudo del miocardio, parece conferir per se un peor pronóstico en los pacientes con esta entidad. Objetivo: evaluar el comportamiento del infarto agudo del miocardio en personas con diabetes mellitus de la provincia de Granma. Métodos: se realizó un estudio transversal y descriptivo con 159 pacientes que ingresaron en la Unidad de Cuidados Intensivos Coronarios del Hospital "Carlos Manuel de Céspedes", de Bayamo, Granma, con diagnóstico de infarto agudo del miocardio, en el período comprendido entre enero de 2010 y junio de 2011. De ellos, 39 con diabetes mellitus y 120 sin ella. De las historias clínicas se extrajeron los datos de las variables demográficas, clínicas y metabólicas estudiadas. Resultados: en los casos con diabetes mellitus el porcentaje de infartos extensos y sin dolor precordial fue superior a los no diabéticos, sin llegar a ser estadísticamente significativo (p= 0,3283 y p= 0,1066. Los pacientes diabéticos presentaron 2,8 veces más posibilidad de sufrir una complicación eléctrica que aquellos sin diabetes mellitus (p= 0,0121. No hubo relación significativa entre las complicaciones mecánicas del infarto agudo del miocardio y la presencia de diabetes mellitus (p= 0,4104. El número de defunciones fue significativamente mayor en los casos con diabetes mellitus, que en los no diabéticos (p= 0,0124. Los niveles de glucemia al ingreso estuvieron significativamente más elevados en los casos complicados y fallecidos, tanto en los diabéticos como en los no diabéticos. Conclusiones: el infarto agudo del miocardio, en los pacientes diabéticos de nuestro medio, con frecuencia se presenta sin dolor precordial, extenso, con complicaciones eléctricas y asociado con una elevada mortalidad. La hiperglucemia al ingreso está relacionada con un incremento de la morbilidad y la mortalidad del infarto agudo del miocardio

  3. Cardiovascular function in pulmonary emphysema.

    Science.gov (United States)

    Visca, Dina; Aiello, Marina; Chetta, Alfredo

    2013-01-01

    Chronic obstructive pulmonary disease (COPD) and chronic cardiovascular disease, such as coronary artery disease, congestive heart failure, and cardiac arrhythmias, have a strong influence on each other, and systemic inflammation has been considered as the main linkage between them. On the other hand, airflow limitation may markedly affect lung mechanics in terms of static and dynamic hyperinflation, especially in pulmonary emphysema, and they can in turn influence cardiac performance as well. Skeletal mass depletion, which is a common feature in COPD especially in pulmonary emphysema patients, may have also a role in cardiovascular function of these patients, irrespective of lung damage. We reviewed the emerging evidence that highlights the role of lung mechanics and muscle mass impairment on ventricular volumes, stroke volume, and stroke work at rest and on exercise in the presence of pulmonary emphysema. Patients with emphysema may differ among COPD population even in terms of cardiovascular function.

  4. Cardiovascular Disease and Thyroid Function

    DEFF Research Database (Denmark)

    Faber, Jens; Selmer, Christian

    2014-01-01

    Thyroid function has a profound effect on the heart, and both all-cause and cardiovascular mortality rates are increased in hyperthyroidism. New-onset atrial fibrillation carries a prolonged risk for the development of hyperthyroidism, suggesting altered availability of thyroid hormones at the ce......Thyroid function has a profound effect on the heart, and both all-cause and cardiovascular mortality rates are increased in hyperthyroidism. New-onset atrial fibrillation carries a prolonged risk for the development of hyperthyroidism, suggesting altered availability of thyroid hormones...... at the cellular level. Subclinical hyperthyroidism is associated with increased left ventricular mass of the heart, which reverts after obtaining euthyroidism. Mortality and risk of major cardiovascular events are increased. Subclinical hypothyroidism is also associated with subtle changes in the heart, e.g. its...

  5. Cognitive dysfunction after cardiovascular surgery

    DEFF Research Database (Denmark)

    Funder, K S; Steinmetz, J; Rasmussen, L S

    2009-01-01

    This review describes the incidence, risk factors, and long-term consequences of cognitive dysfunction after cardiovascular surgery. Postoperative cognitive dysfunction (POCD) is increasingly being recognized as an important complication, especially in the elderly. A highly sensitive neuropsychol......This review describes the incidence, risk factors, and long-term consequences of cognitive dysfunction after cardiovascular surgery. Postoperative cognitive dysfunction (POCD) is increasingly being recognized as an important complication, especially in the elderly. A highly sensitive...... neuropsychological test battery must be used to detect POCD and a well-matched control group is very useful for the analysis and interpretation of the test RESULTS: Cardiovascular surgery is associated with a high incidence of POCD. Cardiopulmonary bypass was thought to explain this difference, but randomized...

  6. Comparing Levels of Anxiety During Bed and Shower Baths in Patients with Acute Myocardial Infarction Comparación del nivel de ansiedad entre el baño de aspersión y el realizado en la cama en pacientes con infarto agudo del miocardio Comparação do nível de ansiedade entre o banho de aspersão e o de leito em pacientes com infarto agudo do miocárdio

    Directory of Open Access Journals (Sweden)

    Juliana de Lima Lopes

    2010-04-01

    Full Text Available This study compared the levels of anxiety presented by patients with acute myocardial infarction in bed and shower baths and the influence of antecedent variables: age, gender, medications, previous hospitalization and/or bed bath, patients' preference regarding the professional's gender, risk factors and anxiety-traits. This crossover study was conducted between February and August 2007 in coronary units. The sample was composed of 71 patients with acute myocardial infarction. The State-Trait Anxiety Inventory (STAI was applied before the baths (bed and shower baths, immediately after the baths and twenty minutes after the second evaluation. Results revealed that patients were more anxious in the bed bath than in the shower in the three assessments (p Este estudio tuvo como objetivo comparar los niveles de ansiedad, generados en el baño en la cama y en el de aspersión, en pacientes con infarto agudo del miocardio, así como la influencia de las variables antecedentes: edad, sexo, medicaciones, internación y/o baño en la cama previo, preferencia del paciente en cuanto al sexo del profesional, factores de riesgo y la ansiedad de trazo. Esta investigación es un estudio cross-over, realizado entre febrero y agosto de 2007, en Unidades Coronarias. La muestra fue constituida por 71 pacientes con infarto agudo del miocardio. El instrumento utilizado fue el IDATE-estado, siendo aplicado antes de los baños (cama y aspersión, inmediatamente después de los baños y veinte minutos después de la segunda evaluación. Los resultados mostraron que los pacientes quedaron más ansiosos cuando realizaron su baño en la cama que cuando realizaron el baño de aspersión, en las tres evaluaciones (pEste estudo teve como objetivo comparar os níveis de ansiedade, gerados no banho no leito e naquele de aspersão, em pacientes com infarto agudo do miocárdio, bem como a influência de variáveis antecedentes: idade, sexo, medicações, internação e/ou banho

  7. Cardiovascular effects of air pollution.

    Science.gov (United States)

    Bourdrel, Thomas; Bind, Marie-Abèle; Béjot, Yannick; Morel, Olivier; Argacha, Jean-François

    2017-11-01

    Air pollution is composed of particulate matter (PM) and gaseous pollutants, such as nitrogen dioxide and ozone. PM is classified according to size into coarse particles (PM 10 ), fine particles (PM 2.5 ) and ultrafine particles. We aim to provide an original review of the scientific evidence from epidemiological and experimental studies examining the cardiovascular effects of outdoor air pollution. Pooled epidemiological studies reported that a 10μg/m 3 increase in long-term exposure to PM 2.5 was associated with an 11% increase in cardiovascular mortality. Increased cardiovascular mortality was also related to long-term and short-term exposure to nitrogen dioxide. Exposure to air pollution and road traffic was associated with an increased risk of arteriosclerosis, as shown by premature aortic and coronary calcification. Short-term increases in air pollution were associated with an increased risk of myocardial infarction, stroke and acute heart failure. The risk was increased even when pollutant concentrations were below European standards. Reinforcing the evidence from epidemiological studies, numerous experimental studies demonstrated that air pollution promotes a systemic vascular oxidative stress reaction. Radical oxygen species induce endothelial dysfunction, monocyte activation and some proatherogenic changes in lipoproteins, which initiate plaque formation. Furthermore, air pollution favours thrombus formation, because of an increase in coagulation factors and platelet activation. Experimental studies also indicate that some pollutants have more harmful cardiovascular effects, such as combustion-derived PM 2.5 and ultrafine particles. Air pollution is a major contributor to cardiovascular diseases. Promotion of safer air quality appears to be a new challenge in cardiovascular disease prevention. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  8. Psychosocial perspectives in cardiovascular disease

    DEFF Research Database (Denmark)

    Pedersen, Susanne S.; von Känel, Roland; Tully, Phillip J

    2017-01-01

    Adaptation to living with cardiovascular disease may differ from patient to patient and is influenced not only by disease severity and limitations incurred by the disease but also by socioeconomic factors (e.g. health literacy), the patients' psychological make-up and susceptibility to distress. Co......-morbid depression and/or anxiety is prevalent in 20% of patients with cardiovascular disease, which may be either transient or chronic. Distress, such as depression, reduces adherence, serves as a barrier to behaviour change and the adoption of a healthy lifestyle, and increases the risk that patients drop out...

  9. Cardiovascular disease incidence and survival

    DEFF Research Database (Denmark)

    Byberg, Stine; Agyemang, Charles; Zwisler, Ann Dorthe

    2016-01-01

    Studies on cardiovascular disease (CVD) incidence and survival show varying results between different ethnic groups. Our aim was to add a new dimension by exploring the role of migrant status in combination with ethnic background on incidence of-and survival from-CVD and more specifically acute...... of some types of cardiovascular disease compared to Danish-born. Family-reunified migrants on the other hand had lower rates of CVD. All migrants had better survival than Danish-born indicating that migrants may not always be disadvantaged in health....

  10. Cardiovascular disease after cancer therapy

    DEFF Research Database (Denmark)

    Aleman, Berthe M P; Moser, Elizabeth C; Nuver, Janine

    2014-01-01

    Improvements in treatment and earlier diagnosis have both contributed to increased survival for many cancer patients. Unfortunately, many treatments carry a risk of late effects including cardiovascular diseases (CVDs), possibly leading to significant morbidity and mortality. In this paper we......, and the mechanisms involved, as well as the extent to which treatments may increase CVD indirectly by increasing cardiovascular risk factors is also important. Systematic collection of data relating treatment details to late effects is needed, and great care is needed to obtain valid and generalisable results...

  11. Cardiovascular risk factors in men

    DEFF Research Database (Denmark)

    Gyllenborg, J; Rasmussen, S L; Borch-Johnsen, Knut

    2001-01-01

    Males have higher risk of cardiovascular disease (CVD) than premenopausal females. Gonadal steroids are probably involved in the gender difference in CVD, but previous results have been conflicting. We investigated the associations between CVD risk factors and sex hormones in a cross-sectional de......Males have higher risk of cardiovascular disease (CVD) than premenopausal females. Gonadal steroids are probably involved in the gender difference in CVD, but previous results have been conflicting. We investigated the associations between CVD risk factors and sex hormones in a cross...

  12. Cardiovascular investigations of airline pilots with excessive cardiovascular risk.

    Science.gov (United States)

    Wirawan, I Made Ady; Aldington, Sarah; Griffiths, Robin F; Ellis, Chris J; Larsen, Peter D

    2013-06-01

    This study examined the prevalence of airline pilots who have an excessive cardiovascular disease (CVD) risk score according to the New Zealand Guideline Group (NZGG) Framingham-based Risk Chart and describes their cardiovascular risk assessment and investigations. A cross-sectional study was performed among 856 pilots employed in an Oceania based airline. Pilots with elevated CVD risk that had been previously evaluated at various times over the previous 19 yr were reviewed retrospectively from the airline's medical records, and the subsequent cardiovascular investigations were then described. There were 30 (3.5%) pilots who were found to have 5-yr CVD risk score of 10-15% or higher. Of the 29 pilots who had complete cardiac investigations data, 26 pilots underwent exercise electrocardiography (ECG), 2 pilots progressed directly to coronary angiograms and 1 pilot with abnormal echocardiogram was not examined further. Of the 26 pilots, 7 had positive or borderline exercise tests, all of whom subsequently had angiograms. One patient with a negative exercise test also had a coronary angiogram. Of the 9 patients who had coronary angiograms as a consequence of screening, 5 had significant disease that required treatment and 4 had either trivial disease or normal coronary arteries. The current approach to investigate excessive cardiovascular risk in pilots relies heavily on exercise electrocardiograms as a diagnostic test, and may not be optimal either to detect disease or to protect pilots from unnecessary invasive procedures. A more comprehensive and accurate cardiac investigation algorithm to assess excessive CVD risk in pilots is required.

  13. Vitamin E and cardiovascular disease

    NARCIS (Netherlands)

    Kleijnen, J.; Knipschild, P.; ter Riet, G.

    1989-01-01

    Randomized clinical trials of the effects of Vitamin E on complaints of intermittent claudication and angina pectoris are reviewed, and their methodological shortcomings are considered. Mechanisms by which Vitamin E might act in cardiovascular disease are discussed. The evidence about the possible

  14. The Relationship Between Microalbuminuria, Cardiovascular ...

    African Journals Online (AJOL)

    Background :In patients with type 2 diabetes, microalbuminuria is an early clinical sign suggestive of vascular damage to the glomerulus. Microalbuminuria has also been currently reported as an important risk factor for cardiovascular disease and becomes relevant in the management of type 2 diabetes. Objectives :This ...

  15. Animal Models of Cardiovascular Diseases

    Directory of Open Access Journals (Sweden)

    Carlos Zaragoza

    2011-01-01

    Full Text Available Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies. Several models have been developed to address cardiovascular complications, including atherothrombotic and cardiac diseases, and the same pathology have been successfully recreated in different species, including small and big animal models of disease. However, genetic and environmental factors play a significant role in cardiovascular pathophysiology, making difficult to match a particular disease, with a single experimental model. Therefore, no exclusive method perfectly recreates the human complication, and depending on the model, additional considerations of cost, infrastructure, and the requirement for specialized personnel, should also have in mind. Considering all these facts, and depending on the budgets available, models should be selected that best reproduce the disease being investigated. Here we will describe models of atherothrombotic diseases, including expanding and occlusive animal models, as well as models of heart failure. Given the wide range of models available, today it is possible to devise the best strategy, which may help us to find more efficient and reliable solutions against human cardiovascular diseases.

  16. Animal models of cardiovascular diseases.

    Science.gov (United States)

    Zaragoza, Carlos; Gomez-Guerrero, Carmen; Martin-Ventura, Jose Luis; Blanco-Colio, Luis; Lavin, Begoña; Mallavia, Beñat; Tarin, Carlos; Mas, Sebastian; Ortiz, Alberto; Egido, Jesus

    2011-01-01

    Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies. Several models have been developed to address cardiovascular complications, including atherothrombotic and cardiac diseases, and the same pathology have been successfully recreated in different species, including small and big animal models of disease. However, genetic and environmental factors play a significant role in cardiovascular pathophysiology, making difficult to match a particular disease, with a single experimental model. Therefore, no exclusive method perfectly recreates the human complication, and depending on the model, additional considerations of cost, infrastructure, and the requirement for specialized personnel, should also have in mind. Considering all these facts, and depending on the budgets available, models should be selected that best reproduce the disease being investigated. Here we will describe models of atherothrombotic diseases, including expanding and occlusive animal models, as well as models of heart failure. Given the wide range of models available, today it is possible to devise the best strategy, which may help us to find more efficient and reliable solutions against human cardiovascular diseases.

  17. NKT cells in cardiovascular diseases

    NARCIS (Netherlands)

    Puijvelde, van G.H.M.; Kuiper, J.

    2017-01-01

    Despite life-style advice and the prescription of cholesterol-lowering and anti-thrombotic drugs, cardiovascular diseases are still the leading cause of death worldwide. Therefore, there is an urgent need for new therapeutic strategies focussing on atherosclerosis, the major underlying pathology of

  18. NKT cells in cardiovascular diseases.

    Science.gov (United States)

    van Puijvelde, Gijs H M; Kuiper, Johan

    2017-12-05

    Despite life-style advice and the prescription of cholesterol-lowering and anti-thrombotic drugs, cardiovascular diseases are still the leading cause of death worldwide. Therefore, there is an urgent need for new therapeutic strategies focussing on atherosclerosis, the major underlying pathology of cardiovascular diseases characterized by an accumulation of lipids in an inflamed arterial/vessel wall. CD1d-restricted lipid-sensing natural killer T (NKT) cells, bridging the innate and adaptive immunity, and CD1d-expressing antigen-presenting cells are detected in atherosclerotic lesions of mice and humans. In this review we will summarize studies that point to a critical role for NKT cells in the pathogenesis of atherosclerosis and other cardiovascular diseases by the secretion of pro-atherogenic cytokines and cytotoxins. These pro-atherogenic NKT cells are potential targets for new therapeutic strategies in the prevention and treatment of cardiovascular diseases. Additionally, proteins transferring lipids during atherosclerosis, which are also important in the loading of lipids onto CD1d and possible endogenous ligands responsible for the activation of NKT cells during atherosclerosis will be discussed. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  19. Digital imaging in cardiovascular radiology

    International Nuclear Information System (INIS)

    Heintzen, P.H.; Brennecke, R.

    1983-01-01

    The present book contains 27 papers presented at an international symposium on digital imaging in cardiovascular radiology held in Kiel in 1982. The main themes were as follows. Introductory reviews, digital systems for X-ray video imaging, quantitative X-ray image analysis, and clinical applications. (MG)

  20. Seasonality of cardiovascular risk factors

    DEFF Research Database (Denmark)

    Marti-Soler, Helena; Gubelmann, Cédric; Aeschbacher, Stefanie

    2014-01-01

    OBJECTIVE: To assess the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies. METHODS: Cross-sectional data from 24 population-based studies from 15 countries, with a total sample size of 237 979 subjects. CVRFs included Body Mass Index (BMI) and waist...

  1. Cardiovascular calcification. An inflammatory disease

    International Nuclear Information System (INIS)

    New, S.E.P.; Aikawa, E.

    2011-01-01

    Cardiovascular calcification is an independent risk factor for cardiovascular morbidity and mortality. This disease of dysregulated metabolism is no longer viewed as a passive degenerative disease, but instead as an active process triggered by pro-inflammatory cues. Furthermore, a positive feedback loop of calcification and inflammation is hypothesized to drive disease progression in arterial calcification. Both calcific aortic valve disease and atherosclerotic arterial calcification may possess similar underlying mechanisms. Early histopathological studies first highlighted the contribution of inflammation to cardiovascular calcification by demonstrating the accumulation of macrophages and T lymphocytes in 'early' lesions within the aortic valves and arteries. A series of in vitro work followed, which gave a mechanistic insight into the stimulation of smooth muscle cells to undergo osteogenic differentiation and mineralization. The emergence of novel technology, in the form of animal models and more recently molecular imaging, has enabled accelerated progression of this field, by providing strong evidence regarding the concept of this disorder as an inflammatory disease. Although there are still gaps in our knowledge of the mechanisms behind this disorder, this review discusses the various studies that have helped form the concept of the inflammation-dependent cardiovascular calcification paradigm. (author)

  2. Laser therapy in cardiovascular disease

    Science.gov (United States)

    Rindge, David

    2009-02-01

    Cardiovascular disease is the number one cause of death worldwide. It is broadly defined to include anything which adversely affects the heart or blood vessels. One-third of Americans have one or more forms of it. By one estimate, average human life expectancy would increase by seven years if it were eliminated. The mainstream medical model seeks mostly to "manage" cardiovascular disease with pharmaceuticals or to surgically bypass or reopen blocked vessels via angioplasty. These methods have proven highly useful and saved countless lives. Yet drug therapy may be costly and ongoing, and it carries the risk of side effects while often doing little or nothing to improve underlying health concerns. Similarly, angioplasty or surgery are invasive methods which entail risk. Laser therapy1 regenerates tissue, stimulates biological function, reduces inflammation and alleviates pain. Its efficacy and safety have been increasingly well documented in cardiovascular disease of many kinds. In this article we will explore the effects of laser therapy in angina, atherosclerosis, coronary artery disease, hypertension, hyperlipidemia, myocardial infarction, stroke and other conditions. The clinical application of various methods of laser therapy, including laserpuncture and transcutaneous, supravascular and intravenous irradiation of blood will be discussed. Implementing laser therapy in the treatment of cardiovascular disease offers the possibility of increasing the health and wellbeing of patients while reducing the costs and enhancing safety of medical care.

  3. Down Syndrome: A Cardiovascular Perspective

    Science.gov (United States)

    Vis, J. C.; Duffels, M. G. J.; Winter, M. M.; Weijerman, M. E.; Cobben, J. M.; Huisman, S. A.; Mulder, B. J. M.

    2009-01-01

    This review focuses on the heart and vascular system in patients with Down syndrome. A clear knowledge on the wide spectrum of various abnormalities associated with this syndrome is essential for skillful management of cardiac problems in patients with Down syndrome. Epidemiology of congenital heart defects, cardiovascular aspects and…

  4. Psychosocial perspectives in cardiovascular disease

    NARCIS (Netherlands)

    Pedersen, S.S.; von Kaenel, R.; Tully, P.J.; Denollet, J.

    Adaptation to living with cardiovascular disease may differ from patient to patient and is influenced not only by disease severity and limitations incurred by the disease but also by socioeconomic factors (e.g. health literacy), the patients’ psychological make-up and susceptibility to distress.

  5. Cardiovascular Risk in Primary Hyperaldosteronism

    NARCIS (Netherlands)

    Prejbisz, A.; Warchol-Celinska, E.; Lenders, J.W.M.; Januszewicz, A.

    2015-01-01

    After the first cases of primary aldosteronism were described and characterized by Conn, a substantial body of experimental and clinical evidence about the long-term effects of excess aldosterone on the cardiovascular system was gathered over the last 5 decades. The prevalence of primary

  6. Lipid measures and cardiovascular disease prediction

    NARCIS (Netherlands)

    van Wijk, D.F.; Stroes, E.S.G.; Kastelein, J.J.P.

    2009-01-01

    Traditional lipid measures are the cornerstone of risk assessment and treatment goals in cardiovascular prevention. Whereas the association between total, LDL-, HDL-cholesterol and cardiovascular disease risk has been generally acknowledged, the rather poor capacity to distinguish between patients

  7. Top 10 Myths about Cardiovascular Disease

    Science.gov (United States)

    ... Thromboembolism Aortic Aneurysm More Top 10 Myths about Cardiovascular Disease Updated:Mar 16,2018 How much do ... Healthy This content was last reviewed July 2015. Cardiovascular Conditions • Conditions Home • Arrhythmia and Atrial Fibrillation • Cardiac ...

  8. Comparative cardiovascular safety of dementia medications

    DEFF Research Database (Denmark)

    Fosbøl, Emil L; Peterson, Eric D; Holm, Ellen

    2012-01-01

    To compare the cardiovascular safety of currently marketed dementia medications in new users in the United States and Denmark.......To compare the cardiovascular safety of currently marketed dementia medications in new users in the United States and Denmark....

  9. Machine learning based analysis of cardiovascular images

    NARCIS (Netherlands)

    Wolterink, JM

    2017-01-01

    Cardiovascular diseases (CVDs), including coronary artery disease (CAD) and congenital heart disease (CHD) are the global leading cause of death. Computed tomography (CT) and magnetic resonance imaging (MRI) allow non-invasive imaging of cardiovascular structures. This thesis presents machine

  10. Detection of cardiovascular anomalies: Hybrid systems approach

    KAUST Repository

    Ledezma, Fernando; Laleg-Kirati, Taous-Meriem

    2012-01-01

    In this paper, we propose a hybrid interpretation of the cardiovascular system. Based on a model proposed by Simaan et al. (2009), we study the problem of detecting cardiovascular anomalies that can be caused by variations in some physiological

  11. Residual generator for cardiovascular anomalies detection

    KAUST Repository

    Belkhatir, Zehor; Laleg-Kirati, Taous-Meriem; Tadjine, Mohamed

    2014-01-01

    This paper discusses the possibility of using observer-based approaches for cardiovascular anomalies detection and isolation. We consider a lumped parameter model of the cardiovascular system that can be written in a form of nonlinear state

  12. Sex steroids and cardiovascular disease

    Directory of Open Access Journals (Sweden)

    Bu Beng Yeap

    2014-04-01

    Full Text Available As men grow older, testosterone (T levels decline and the significance of this change is debated. The evidence supporting a causal role for lower circulating T, or its metabolites dihydrotestosterone (DHT and estradiol, in the genesis of atherosclerosis and cardiovascular disease (CVD in men is limited. Observational studies associate low baseline T levels with carotid atherosclerosis, aortic and peripheral vascular disease, and with the incidence of cardiovascular events and mortality. Studies using mass spectrometry suggest that when total T is assayed optimally, calculation of free T might not necessarily improve risk stratification. There is limited evidence to support an association of estradiol with CVD. Interventional studies of T therapy in men with coronary artery disease have shown beneficial effects on exercise-induced myocardial ischemia. However, placebo-controlled, randomized clinical trials (RCTs of T therapy in men with the prespecified outcomes of cardiovascular events or deaths are lacking. Meta-analyses of randomized controlled trials of T published up to 2010 found no increase in cardiovascular events, mortality, or prostate cancer with therapy. Recently, in a trial of older men with mobility limitations, men randomized to receive a substantial dose of T reported cardiovascular adverse effects. This phenomenon was not reported from a comparable trial where men received a more conservative dose of T, suggesting a prudent approach should be adopted when considering therapy in frail older men with existing CVD. Adequately powered RCTs of T in middle-aged and older men are needed to clarify whether or not hormonal intervention would reduce the incidence of CVD.

  13. [Thyroid hormones and cardiovascular system].

    Science.gov (United States)

    Límanová, Zdeňka; Jiskra, Jan

    Cardiovascular system is essentially affected by thyroid hormones by way of their genomic and non-genomic effects. Untreated overt thyroid dysfunction is associated with higher cardiovascular risk. Although it has been studied more than 3 decades, in subclinical thyroid dysfunction the negative effect on cardiovascular system is much more controversial. Large meta-analyses within last 10 years have shown that subclinical hyperthyroidism is associated with higher cardiovascular risk than subclinical hypothyroidism. Conversely, in patients of age > 85 years subclinical hypothyroidism was linked with lower mortality. Therefore, subclinical hyperthyroidism should be rather treated in the elderly while subclinical hypothyroidism in the younger patients and the older may be just followed. An important problem on the border of endocrinology and cardiology is amiodarone thyroid dysfunction. Effective and safe treatment is preconditioned by distinguishing of type 1 and type 2 amiodarone induced hyperthyroidism. The type 1 should be treated with methimazol, therapeutic response is prolonged, according to recent knowledge immediate discontinuation of amiodarone is not routinely recommended and patient should be usually prepared to total thyroidectomy, or rather rarely 131I radioiodine ablation may be used if there is appropriate accumulation. In the type 2 there is a promt therapeutic response on glucocorticoids (within 1-2 weeks) with permanent remission or development of hypothyroidism. If it is not used for life-threatening arrhytmias, amiodarone may be discontinuated earlier (after several weeks). Amiodarone induced hypothyroidism is treated with levothyroxine without amiodarone interruption.Key words: amiodarone induced thyroid dysfunction - atrial fibrillation - cardiovascular risk - heart failure - hyperthyroidism - hypothyroidism - thyroid stimulating hormone.

  14. Sex steroids and cardiovascular disease

    Science.gov (United States)

    Yeap, Bu Beng

    2014-01-01

    As men grow older, testosterone (T) levels decline and the significance of this change is debated. The evidence supporting a causal role for lower circulating T, or its metabolites dihydrotestosterone (DHT) and estradiol, in the genesis of atherosclerosis and cardiovascular disease (CVD) in men is limited. Observational studies associate low baseline T levels with carotid atherosclerosis, aortic and peripheral vascular disease, and with the incidence of cardiovascular events and mortality. Studies using mass spectrometry suggest that when total T is assayed optimally, calculation of free T might not necessarily improve risk stratification. There is limited evidence to support an association of estradiol with CVD. Interventional studies of T therapy in men with coronary artery disease have shown beneficial effects on exercise-induced myocardial ischemia. However, placebo-controlled, randomized clinical trials (RCTs) of T therapy in men with the prespecified outcomes of cardiovascular events or deaths are lacking. Meta-analyses of randomized controlled trials of T published up to 2010 found no increase in cardiovascular events, mortality, or prostate cancer with therapy. Recently, in a trial of older men with mobility limitations, men randomized to receive a substantial dose of T reported cardiovascular adverse effects. This phenomenon was not reported from a comparable trial where men received a more conservative dose of T, suggesting a prudent approach should be adopted when considering therapy in frail older men with existing CVD. Adequately powered RCTs of T in middle-aged and older men are needed to clarify whether or not hormonal intervention would reduce the incidence of CVD. PMID:24407188

  15. Sleep apnea and cardiovascular risk.

    Science.gov (United States)

    Floras, John S

    2014-01-01

    Sleep apnea is evident in approximately 10% of adults in the general population, but in certain cardiovascular diseases, and in particular those characterized by sodium and water retention, its prevalence can exceed 50%. Although sleep apnea is not as yet integrated into formal cardiovascular risk assessment algorithms, there is increasing awareness of its importance in the causation or promotion of hypertension, coronary artery disease, heart failure, atrial arrhythmias, and stroke, and thus, not surprisingly, as a predictor of premature cardiovascular death. Sleep apnea manifests as two principal phenotypes, both characterized by respiratory instability: obstructive (OSA), which arises when sleep-related withdrawal of respiratory drive to the upper airway dilator muscles is superimposed upon a narrow and highly compliant airway predisposed to collapse, and central (CSA), which occurs when the partial pressure of arterial carbon dioxide falls below the apnea threshold, resulting in withdrawal of central drive to respiratory muscles. The present objectives are to: (1) review the epidemiology and patho-physiology of OSA and CSA, with particular emphasis on the role of renal sodium retention in initiating and promoting these processes, and on population studies that reveal the long-term consequences of untreated OSA and CSA; (2) illustrate mechanical, autonomic, chemical, and inflammatory mechanisms by which OSA and CSA can increase cardiovascular risk and event rates by initiating or promoting hypertension, atherosclerosis, coronary artery disease, heart failure, arrhythmias, and stroke; (3) highlight insights from randomized trials in which treating sleep apnea was the specific target of therapy; (4) emphasize the present lack of evidence that treating sleep apnea reduces cardiovascular risk and the current clinical equipoise concerning treatment of asymptomatic patients with sleep apnea; and (5) consider clinical implications and future directions of clinical

  16. Resting cardiovascular function improvements in adult men ...

    African Journals Online (AJOL)

    Impaired cardiovascular function increases the risk for fatal and non-fatal cardiovascular disease, renal disease and all-cause mortality. Research has demonstrated an inverse relationship between these cardiovascular impairments and exercise. However, previous research has mainly focused on aerobic training since ...

  17. 14 CFR 67.111 - Cardiovascular.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Cardiovascular. 67.111 Section 67.111 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN MEDICAL STANDARDS AND CERTIFICATION First-Class Airman Medical Certificate § 67.111 Cardiovascular. Cardiovascular...

  18. 14 CFR 67.311 - Cardiovascular.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Cardiovascular. 67.311 Section 67.311 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN MEDICAL STANDARDS AND CERTIFICATION Third-Class Airman Medical Certificate § 67.311 Cardiovascular. Cardiovascular...

  19. 14 CFR 67.211 - Cardiovascular.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Cardiovascular. 67.211 Section 67.211 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN MEDICAL STANDARDS AND CERTIFICATION Second-Class Airman Medical Certificate § 67.211 Cardiovascular. Cardiovascular...

  20. Características clínicas, angiográficas y desenlaces clínicos en adultos mayores de 65 años con síndrome coronario agudo sin elevación del segmento ST

    Directory of Open Access Journals (Sweden)

    James Díaz

    2017-09-01

    Discusión: Los pacientes de edad mayor con síndrome coronario agudo sin elevación del ST tienen características similares a las reportadas en publicaciones de otras latitudes. Sin embargo, a diferencia de lo reportado en la literatura internacional no se logró demostrar que la edad mayor a 65 años constituya un factor de riesgo independiente para desenlaces clínicos adversos en esta población.

  1. Prevalencia de infarto de miocardio en un programa de riesgo cardiovascular de una institución prestadora de salud en Armenia–Quindío

    Directory of Open Access Journals (Sweden)

    Carlos A. Bedoya-Ríos

    2016-11-01

    Resultados y conclusiones: En la población del programa de riesgo cardiovascular se encontraron 293 casos con antecedente de infarto agudo de miocardio, con una prevalencia de 2,49%. La edad promedio en hombres fue de 66,62 años y en mujeres 69,58 años (p = 0,02. El colesterol HDL en hombres fue de 39,61 mg/dl y en mujeres de 46,58 mg/dl (p = 0,01. Los niveles de colesterol LDL se encontraron elevados según lo recomendado en prevención secundaria (110,04 mg/dl. El principal factor de riesgo encontrado fue la hipertensión arterial (84%, seguido por otros como el sedentarismo (63,48%, el sobrepeso y la obesidad (40,61 y 13,98% respectivamente, el hábito de fumar (12,97% y el consumo de alcohol (5,46%, que fueron mayores en los hombres.

  2. Primary Prevention of Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Danny J. Eapen, MD

    2016-09-01

    Full Text Available Cardiovascular disease (CVD is the leading cause of death worldwide. This article focuses on current guidelines for the primary prevention of CVD and addresses management of key risk factors. Dietary modification, weight loss, exercise, and tobacco use cessation are specific areas where focused efforts can successfully reduce CVD risk on both an individual and a societal level. Specific areas requiring management include dyslipidemia, hypertension, physical activity, diabetes, aspirin use, and alcohol intake. These preventive efforts have major public health implications. As the global population continues to grow, health care expenditures will also rise, with the potential to eventually overwhelm the health care system. Therefore it is imperative to apply our collective efforts on CVD prevention to improve the cardiovascular health of individuals, communities, and nations.

  3. Molecular imaging by cardiovascular MR.

    Science.gov (United States)

    Cyrus, Tillmann; Lanza, Gregory M; Wickline, Samuel A

    2007-01-01

    Do molecularly-targeted contrast agents have what it takes to usher in a paradigm shift as to how we will image cardiovascular disease in the near future? Moreover, are non-invasive vulnerable plaque detection and preemptive treatments with these novel nanoparticulate agents within reach for clinical applications? In this article, we attempt to make a compelling case for how the advent of molecularly-targeted nanoparticle technology may change the way we detect atherosclerotic lesions, determine their clinical significance and even provide non-invasive treatments. Focusing on imaging with cardiovascular MR, an overview of the latest developments in this rapidly evolving field of so-called "intelligent" contrast agents that are able to interrogate the vascular wall and various complementary advanced imaging technologies are presented.

  4. Cardiovascular Prevention of Cognitive Decline

    Directory of Open Access Journals (Sweden)

    Jean-Jacques Monsuez

    2011-01-01

    Full Text Available Midlife cardiovascular risk factors, including diabetes, hypertension, dyslipemia, and an unhealthy lifestyle, have been linked to subsequent incidence, delay of onset, and progression rate of Alzheimer disease and vascular dementia. Conversely, optimal treatment of cardiovascular risk factors prevents and slows down age-related cognitive disorders. The impact of antihypertensive therapy on cognitive outcome in patients with hypertension was assessed in large trials which demonstrated a reduction in progression of MRI white matter hyperintensities, in cognitive decline and in incidence of dementia. Large-scale database correlated statin use and reduction in the incidence of dementia, mainly in patients with documented atherosclerosis, but clinical trials failed to reach similar conclusions. Whether a multitargeted intervention would substantially improve protection, quality of life, and reduce medical cost expenditures in patients with lower risk profile has not been ascertained. This would require appropriately designed trials targeting large populations and focusing on cognitive decline as a primary outcome endpoint.

  5. Hiperhomocisteinemia e o risco cardiovascular

    OpenAIRE

    Gannabathula Sree Vani

    2002-01-01

    Nível elevado de homocisteína (Hcy) no plasma é considerado fator de risco de doença cardiovascular. Consumo reduzido de vitaminas B6, B12 e ácido fólico tem sido relacionado com hiperhomocisteinemia. O objetivo desse estudo foi verificar o consumo de vitaminas B6, B12 e ácido fólico nas populações urbana e rural, bem como a correlação dos níveis plasmáticos dessas vitaminas com os níveis plasmáticos de Hcy. Também determinamos os níveis séricos de lipídeos e avaliamos o risco cardiovascular ...

  6. Erectile dysfunction in the cardiovascular patient.

    Science.gov (United States)

    Vlachopoulos, Charalambos; Jackson, Graham; Stefanadis, Christodoulos; Montorsi, Piero

    2013-07-01

    Erectile dysfunction is common in the patient with cardiovascular disease. It is an important component of the quality of life and it also confers an independent risk for future cardiovascular events. The usual 3-year time period between the onset of erectile dysfunction symptoms and a cardiovascular event offers an opportunity for risk mitigation. Thus, sexual function should be incorporated into cardiovascular disease risk assessment for all men. A comprehensive approach to cardiovascular risk reduction (comprising of both lifestyle changes and pharmacological treatment) improves overall vascular health, including sexual function. Proper sexual counselling improves the quality of life and increases adherence to medication. This review explores the critical connection between erectile dysfunction and cardiovascular disease and evaluates how this relationship may influence clinical practice. Algorithms for the management of patient with erectile dysfunction according to the risk for sexual activity and future cardiovascular events are proposed.

  7. Cardiovascular effects of air pollution.

    Science.gov (United States)

    Brook, Robert D

    2008-09-01

    Air pollution is a heterogeneous mixture of gases, liquids and PM (particulate matter). In the modern urban world, PM is principally derived from fossil fuel combustion with individual constituents varying in size from a few nanometres to 10 microm in diameter. In addition to the ambient concentration, the pollution source and chemical composition may play roles in determining the biological toxicity and subsequent health effects. Nevertheless, studies from across the world have consistently shown that both short- and long-term exposures to PM are associated with a host of cardiovascular diseases, including myocardial ischaemia and infarctions, heart failure, arrhythmias, strokes and increased cardiovascular mortality. Evidence from cellular/toxicological experiments, controlled animal and human exposures and human panel studies have demonstrated several mechanisms by which particle exposure may both trigger acute events as well as prompt the chronic development of cardiovascular diseases. PM inhaled into the pulmonary tree may instigate remote cardiovascular health effects via three general pathways: instigation of systemic inflammation and/or oxidative stress, alterations in autonomic balance, and potentially by direct actions upon the vasculature of particle constituents capable of reaching the systemic circulation. In turn, these responses have been shown to trigger acute arterial vasoconstriction, endothelial dysfunction, arrhythmias and pro-coagulant/thrombotic actions. Finally, long-term exposure has been shown to enhance the chronic genesis of atherosclerosis. Although the risk to one individual at any single time point is small, given the prodigious number of people continuously exposed, PM air pollution imparts a tremendous burden to the global public health, ranking it as the 13th leading cause of morality (approx. 800,000 annual deaths).

  8. Emotion, motivation, and cardiovascular response

    OpenAIRE

    Kreibig Sylvia D

    2012-01-01

    Cardiovascular (CV) response consists of changes in CV parameters such as heart rate blood pressure and heart contraction force in reaction to an event or set of events. It is significant for multiple reasons perhaps most notably because research suggests that it affects the development and progression of heart disease. Disease models vary but most assume that characteristically strong and prolonged CV responses confer health risk. Psychologists have long suspected linkages between motivation...

  9. Causas de la no-trombólisis en el infarto agudo del miocardio y beneficios de su uso Causes of non-thrombolysis in the acute myocardial infarction and benefits from its use

    Directory of Open Access Journals (Sweden)

    Christian Leyva de la Torre

    2005-08-01

    Full Text Available Se realizó un estudio descriptivo con enfoque de riesgo mediante la revisión de las 242 historias clínicas de todos los pacientes egresados vivos o fallecidos con diagnóstico de infarto agudo del miocardio en el Hospital Docente Clinicoquirúrgico "Dr. Salvador Allende" durante el 2002, a fin de determinar las causas principales por las que se difiere el tratamiento trombolítico en esta entidad. Se efectuó la trombólisis al 29,8 % de los pacientes con infarto agudo del miocardio que llegaron a dicha institución; sin embargo, para el 11,6 % de casos no hay justificación de la no aplicación de la trombólisis. Las principales causas de la no aplicación de esta fueron la llegada al hospital pasadas las primeras 12 h del inicio del dolor (17,4 % y la no elevación del segmento ST (11,2 %. La edad mayor de 75 años no constituyó un riesgo de no elección para el tratamiento trombolítico (OR= 1,45 [0,75-2,81 IC= 95 %]; p= 0,267. La mortalidad por infarto agudo del miocardio aun se mantiene elevada con el 26 %. La edad mayor de 75 años (OR= 3,41 (1,83-6,35 IC= 95 %]; p= 0,000, el tiempo de llegada al hospital mayor de 6 h (OR= 2,36 [1,17-4,75 IC= 95 %]; p= 0,014, y la no aplicación del tratamiento trombolítico (OR= 3,82 [1,71-8,53 IC= 95 %]; p= 0,001 constituyeron elementos de riesgo relacionados de forma estadísticamente significativa con la letalidad del infarto. El riego de morir se mantuvo aun en los pacientes en que no se aplicó la trombólisis del subgrupo de mayores de 75 años (OR= 8,04 [1,63-39,69 IC= 95 %]; p= 0,004.A descriptive study with risk approach was undertaken by reviewing 242 medical histories of the living discharged patients or dead patients with diagnosis of acute myocardial infarction at "Dr. Salvador Allende" Clinical and Surgical Teaching Hospital , aimed at determining the main causes for deferring the thrombolytic treatment in this entity. Thrombolysis was performed in 29.8 % of the patients with acute

  10. Acute and chronic pain: a narrative review of the literature Dolor agudo y crónico: revisión narrativa de la literatura Dor aguda e crônica: revisão narrativa da literatura

    Directory of Open Access Journals (Sweden)

    Ana Maria Calil Sallum

    2012-01-01

    Full Text Available The study objectives were to identify the organic, emotional and psychic prevalent consequences in patients with acute and chronic pain and punctuate the main assessment tools for these pains. A narrative review of the literature was conducted using descriptors related to pain measurement, signs and symptoms, totalizing 184 articles. The electronic databases MEDLINE and LILACS were searched from January 2000 to December 2010. The review pointed out a series of conclusive studies about the organic repercussions more frequent in acute and chronic pain conditions and the use of different rating scales for both situations. It is believed that these findings could be of great values for health teams, could contribute with a better practice and with customer satisfaction in the hospital scenario and at home.Los objetivos del estudio fueron identificar las repercusiones orgánicas, emocionales y psíquicas prevalentes en pacientes con dolor agudo y dolor crónico y puntuar los principales instrumentos de evaluación para esos dolores. Se realizó una revisión narrativa de la literatura, utilizándose descriptores relacionados a la medición del dolor, cuidados de enfermería, signos y síntomas, en un total de 184 artículos. Las bases electrónicas investigadas fueron LILACS y MEDLINE, entre enero de 2000 a diciembre de 2010. Esta revisión puntuó una serie de estudios conclusivos sobre las repercusiones orgánicas más frecuentes en los cuadros álgicos agudos y crónicos y el uso de escalas de evaluación distintas para ambas situaciones. Se cree que esos hallazgos podrán ser de gran valía para los equipos de salud y que contribuya con mejores prácticas y satisfacción del cliente en los escenarios intra hospitalario y domiciliario.Os objetivos do estudo foram identificar as repercussões orgânicas, emocionais e psíquicas prevalentes em pacientes com dor aguda e dor crônica e pontuar os principais instrumentos de avaliação para essas dores

  11. Fetal Programming and Cardiovascular Pathology

    Science.gov (United States)

    Alexander, Barbara T.; Dasinger, John Henry; Intapad, Suttira

    2016-01-01

    Low birth weight serves as a crude proxy for impaired growth during fetal life and indicates a failure for the fetus to achieve its full growth potential. Low birth weight can occur in response to numerous etiologies that include complications during pregnancy, poor prenatal care, parental smoking, maternal alcohol consumption or stress. Numerous epidemiological and experimental studies demonstrate that birth weight is inversely associated with blood pressure and coronary heart disease. Sex and age impact the developmental programming of hypertension. In addition, impaired growth during fetal life also programs enhanced vulnerability to a secondary insult. Macrosomia, which occurs in response to maternal obesity, diabetes and excessive weight gain during gestation, is also associated with increased cardiovascular risk. Yet, the exact mechanisms that permanently change the structure, physiology and endocrine health of an individual across their lifespan following altered growth during fetal life are not entirely clear. Transmission of increased risk from one generation to the next in the absence of an additional prenatal insult indicates an important role for epigenetic processes. Experimental studies also indicate that the sympathetic nervous system, the renin angiotensin system, increased production of oxidative stress and increased endothelin play an important role in the developmental programming of blood pressure in later life. Thus, this review will highlight how adverse influences during fetal life and early development program an increased risk for cardiovascular disease including high blood pressure and provide an overview of the underlying mechanisms that contribute to the fetal origins of cardiovascular pathology. PMID:25880521

  12. Apolipoprotein E and cardiovascular disease

    Directory of Open Access Journals (Sweden)

    Adriana Moreno Valladares

    2006-01-01

    Full Text Available Apolipoprotein E is a polymorphic glycoprotein who interacts with the lipoprotein receptors (LRP-Receptor Related Protein and the receptors for low density lipoproteins of (LDL receptors. When lipoproteins bring up the receptors begins lipids captation and degradation which allows cholesterol utilization, taking place an intracellular auto regulation. The three isoforms of greater importance: Apo E2, E3 and E4 are product of three alleles e2, e3, e4 of one only gene. This factor is related with the amount of lipoproteins that contains ApoE for E/B receptors. A low concentration of lipoproteins with ApoE can increase the activity of LDL receptors and consequently downward the circulating LDL. In the other hand particles with Apo E3 or Apo E4, can cause a downward regulation of LDL and in this way produces a LDL plasma elevation. Many studies in human populations have concluded that this polymorphism of apoE and the plasma variation of lipoproteins are associated with cardiovascular risk. Cardiovascular disease is the result of different interaction between factors which are genetic factor specially ApoE polymorphism e4 allelic of ApoE can explain, in some degree, the greater frequency of cardiovascular disease in those who carries it.

  13. Perindopril for improving cardiovascular events

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    DiNicolantonio JJ

    2014-08-01

    Full Text Available James J DiNicolantonio, James H O'Keefe Department of Preventive Cardiology, Saint Luke's Mid America Heart Institute, Kansas City, MO, USAIn a recent review in Vascular Health and Risk Management Wang et al state that “In mainly placebo-controlled cardiovascular (CV-outcome studies in patients with hypertension, CV benefits with perindopril were associated with large reductions in BP.”1 However, perindopril in the European Trial on Reduction of Cardiac Events With Perindopril in Stable Coronary Artery Disease (EUROPA study significantly reduced major cardiovascular events despite a small reduction (approximately 4 mmHg in systolic blood pressure from baseline.2,3 Additionally, the average baseline blood pressure in the EUROPA was just 137/82 mmHg, and in those without hypertension, perindopril still provided a 20% reduction in the combined endpoint of cardiovascular death, myocardial infarction, and cardiac arrest.4,5 In fact, patients receiving perindopril with a baseline systolic blood pressure of <120 mmHg had the greatest reduction in the primary event.6 View original paper by Wang and colleagues. 

  14. Cocoa, chocolate, and cardiovascular disease.

    Science.gov (United States)

    Galleano, Monica; Oteiza, Patricia I; Fraga, Cesar G

    2009-12-01

    A significant body of evidence demonstrates that diets rich in fruits and vegetables promote health and attenuate, or delay, the onset of various diseases, including cardiovascular disease, diabetes, certain cancers, and several other age-related degenerative disorders. The concept that moderate chocolate consumption could be part of a healthy diet has gained acceptance in past years based on the health benefits ascribed to selected cocoa components. Specifically, cocoa as a plant and chocolate as food contain a series of chemicals that can interact with cell and tissue components, providing protection against the development and amelioration of pathological conditions. The most relevant effects of cocoa and chocolate have been related to cardiovascular disease. The mechanisms behind these effects are still under investigation. However, the maintenance or restoration of vascular NO production and bioavailability and the antioxidant effects are the mechanisms most consistently supported by experimental data. This review will summarize the most recent research on the cardiovascular effects of cocoa flavanols and related compounds.

  15. Cardiovascular Effects of Calcium Supplements

    Directory of Open Access Journals (Sweden)

    Ian R. Reid

    2013-07-01

    Full Text Available Calcium supplements reduce bone turnover and slow the rate of bone loss. However, few studies have demonstrated reduced fracture incidence with calcium supplements, and meta-analyses show only a 10% decrease in fractures, which is of borderline statistical and clinical significance. Trials in normal older women and in patients with renal impairment suggest that calcium supplements increase the risk of cardiovascular disease. To further assess their safety, we recently conducted a meta-analysis of trials of calcium supplements, and found a 27%–31% increase in risk of myocardial infarction, and a 12%–20% increase in risk of stroke. These findings are robust because they are based on pre-specified analyses of randomized, placebo-controlled trials and are consistent across the trials. Co-administration of vitamin D with calcium does not lessen these adverse effects. The increased cardiovascular risk with calcium supplements is consistent with epidemiological data relating higher circulating calcium concentrations to cardiovascular disease in normal populations. There are several possible pathophysiological mechanisms for these effects, including effects on vascular calcification, vascular cells, blood coagulation and calcium-sensing receptors. Thus, the non-skeletal risks of calcium supplements appear to outweigh any skeletal benefits, and are they appear to be unnecessary for the efficacy of other osteoporosis treatments.

  16. Fetal programming and cardiovascular pathology.

    Science.gov (United States)

    Alexander, Barbara T; Dasinger, John Henry; Intapad, Suttira

    2015-04-01

    Low birth weight serves as a crude proxy for impaired growth during fetal life and indicates a failure for the fetus to achieve its full growth potential. Low birth weight can occur in response to numerous etiologies that include complications during pregnancy, poor prenatal care, parental smoking, maternal alcohol consumption, or stress. Numerous epidemiological and experimental studies demonstrate that birth weight is inversely associated with blood pressure and coronary heart disease. Sex and age impact the developmental programming of hypertension. In addition, impaired growth during fetal life also programs enhanced vulnerability to a secondary insult. Macrosomia, which occurs in response to maternal obesity, diabetes, and excessive weight gain during gestation, is also associated with increased cardiovascular risk. Yet, the exact mechanisms that permanently change the structure, physiology, and endocrine health of an individual across their lifespan following altered growth during fetal life are not entirely clear. Transmission of increased risk from one generation to the next in the absence of an additional prenatal insult indicates an important role for epigenetic processes. Experimental studies also indicate that the sympathetic nervous system, the renin angiotensin system, increased production of oxidative stress, and increased endothelin play an important role in the developmental programming of blood pressure in later life. Thus, this review will highlight how adverse influences during fetal life and early development program an increased risk for cardiovascular disease including high blood pressure and provide an overview of the underlying mechanisms that contribute to the fetal origins of cardiovascular pathology. © 2015 American Physiological Society.

  17. Riesgo cardiovascular, una herramienta útil para la prevención de las enfermedades cardiovasculares Cardiovascular risk, a useful tool for prevention of cardiovascular diseases

    Directory of Open Access Journals (Sweden)

    Jorge Vega Abascal

    2011-03-01

    Full Text Available El riesgo cardiovascular se define como la probabilidad de padecer un evento cardiovascular en un determinado período. Mejorar la exactitud en la predicción del riesgo requiere la evaluación y el tratamiento de múltiples factores de riesgo cardiovascular, los que tienen un efecto sinérgico, más que aditivo, sobre el riesgo cardiovascular total. El cálculo utilizando métodos cuantitativos es más preciso que el obtenido con métodos cualitativos. La predicción del riesgo cardiovascular ha constituido, en los últimos años, la piedra angular en las guías clínicas de prevención cardiovascular, y deviene una herramienta útil del Médico de Familia para establecer prioridades en la atención primaria, mejorando la atención a los pacientes y eligiendo más eficazmente la terapéutica a seguir, con el objetivo de acercarnos más a la realidad multifactorial de las enfermedades cardiovasculares y a su prevención.The cardiovascular risk is defined like a probability of suffering a cardiovascular event in a determined period. To improve the accuracy in risk prediction requires the assessment and treatment of different cardiovascular risk factors, which have a synergistic effect more than additive on the total cardiovascular risk. The calculus using quantitative methods is more accurate than that obtained with qualitative methods. The prediction of cardiovascular risk has been in past years the cornerstone in clinical guidances of cardiovascular prevention and becomes an useful tool for Family Physician to establish priorities in the primary care, improving the patients care and selecting in a more effective way the therapy to be followed to bring closer more to multifactor reality of cardiovascular diseases and its prevention.

  18. Cirurgia de revascularização no infarto agudo do miocárdio Coronary artery bypass following acute myocardial infarction

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    Luiz Antônio Castilho Teno

    1990-04-01

    Full Text Available O tratamento do infarto agudo do miocárdio conta, hoje, com um leque de opções terapêuticas, sempre com o objetivo de reduzir o dano ao ventrículo esquerdo, Dentre as possibilidades, a revascularização cirúrgica encontra seu lugar, ligado, principalmente, à reperfusão após trombolíticos e às complicações da angioplastia. No Instituto do Coração da Santa Casa de Ribeirão Preto, no período de julho/87 a julho/89, foram realizadas 262 cirurgias de revascularização do miocárdio, sendo 23 (8,7% na fase aguda do infarto. Destes, 19 eram homens e quatro mulheres, com idade entre 42 e 75 anos, média de 58,5. A indicação cirúrgica compreendeu: persistência da dor em 15 (65% ocasiões, artéria reaberta após trombolítico em cinco (22%, artéria reaberta espontaneamente em dois (9% e comprometimento multiarterial em um (4%. Os fatores associados à precocidade do procedimento cirúrgico foram: ATP complicada com espasmo e oclusão arterial em oito pacientes, uso prévio de trombolítico em sete, ATP sem sucesso em quatro, arritmia cardíaca em dois e choque cardiogênico em um. A localização do IAM ao ECG foi de parede anterior em 14 (60,8% casos e parede inferior em nove (39,2%. Em 18 (78,4% havia presença de onda Q e, nos restantes, ausência. A dosagem de enzimas (CKMB variou de 15 a 104 U, média 58,7 U. A cineventriculografia demonstrou lesão isolada da artéria do IAM em nove (39,1% pacientes, lesão da artéria do IAM + lesão de outras artérias em oito (34,7%, lesão da artéria do IAM + infarto prévio de outra área em três (13% e obstrução total da artéria do IAM + lesão de outras artérias em três (13% casos. O período de tempo entre o início da dor e a cirurgia variou de duas horas a duas semanas, média 4,6 dias. O número de pontes, mamária ou safena, por paciente foi, em média, de 1,7, A proteção miocárdica foi realizada com hipotermia leve e solução cardioplégica cristalóide. A anoxia mioc

  19. Tratamento de uma coorte de pacientes com infarto agudo do miocárdio com supradesnivelamento do segmento ST Tratamiento de una cohorte de pacientes con infarto agudo de miocardio con supradesnivel del segmento ST Treatment of a cohort of patients with acute myocardial infarction and ST-segment elevation

    Directory of Open Access Journals (Sweden)

    Jamil da Silva Soares

    2009-06-01

    Full Text Available FUNDAMENTO: Trombólise e angioplastia transluminal coronariana (ATC primária são técnicas bem estabelecidas, mas grande parte dos pacientes com infarto agudo do miocárdio com supradesnivelamento do segmento ST (IAM com SST não as recebem quando do atendimento hospitalar. OBJETIVO: Descrever tratamentos inicial e final e desfechos de uma coorte com IAM com SST. MÉTODOS: Analisados, da internação até a alta, 158 pacientes com IAM com SST, de uma população total de 351 pacientes internados com (SCA nos hospitais de Campos dos Goytacazes, entre 2004 e 2006. RESULTADOS: Dos 158 pacientes com IAM com SST, 67,7% chegaram ao hospital nos primeiros 180 minutos, 81,3% em 360 minutos e 8,4% após doze horas. Realizados 148 estudos cinecoronariográficos (93,7%. Observadas lesões de mais de 70% em 266 territórios arteriais. Tratamento inicial foi ATC em 41(26%, trombolíticos em 50 (32%, com 80% de sucesso. Tratamento clínico em 67 (42%. Cerca de 35% dos pacientes deveriam ser trombolizados mas não o foram. No tratamento final foram 93 ATCs, 89 delas com sucesso angiográfico (95,7, sangramento 2 (2,2, oclusão subaguda 2 (2,2%, dissecção tronco 1 (1,1, pseudo aneurisma 1 (1,1. Nenhum óbito durante angioplastia; na evolução, houve dois óbitos (2,1%. Doze pacientes submetidos a cirurgia de revascularização miocárdica (CRM. Tratamento clínico 53 (33%, com 11 óbitos (20,7%. Letalidade global 9,5%, consideradas as três formas de tratamento. CONCLUSÃO: Pacientes atendidos em tempo adequado para reperfusão, porém 1/3 deles não recebeu o procedimento. Tratamento predominante foi ATC, com baixa morbidade. Dois óbitos na evolução. Baixa letalidade global.FUNDAMENTO: La trombólisis y la angioplastia transluminal coronaria (ATC primaria son técnicas bien establecidas, sin embargo gran parte de los pacientes con infarto agudo de miocardio con supradesnivel del segmento ST (IAM con SST no las reciben cuando de la atenci

  20. Efeitos agudos de levosimendana e dobutamina na duração do QRS em Pacientes com insuficiência cardíaca Efectos agudos de levosimendana y dobutamina en la duración del QRS en pacientes con insuficiencia cardíaca Acute effects of levosimendan and dobutamine on QRS duration in patients with heart failure

    Directory of Open Access Journals (Sweden)

    Osman Can Yontar

    2010-12-01

    Full Text Available FUNDAMENTO: A levosimendana é um novo agente inotrópico que aumenta a contratilidade cardíaca sem aumentar a captação celular de cálcio, de forma a não causar sobrecarga de cálcio e arritmias relacionadas. Em pacientes com insuficiência cardíaca (IC, a duração prolongada do QRS está associada com um aumento no risco de mortalidade e morte súbita cardíaca. Mudanças estruturais no ventrículo esquerdo podem levar à contração assíncrona, causando atraso de condução e um QRS prolongado no ECG de superfície. OBJETIVO: O objetivo do presente estudo foi comparar os efeitos agudos de levosimendana e dobutamina na duração do QRS em pacientes com IC grave e ritmo sinusal. MÉTODOS: 60 pacientes consecutivos com IC isquêmica foram incluídos no estudo e randomizados em dois grupos para infusão de levosimendana (n=37 ou dobutamina (n=23. 67,2 % eram homens; a média da idade era 66,4 ± 9,2 anos para todos os pacientes. A duração basal do QRS nos grupos levosimendana e dobutamina foi 120,44 ± 23,82 ms vs 116,59 ± 13,80 ms respectivamente. A fração de ejeção do ventrículo esquerdo (FEVE estava diminuída em ambos os grupos (23,15 ± 8,3 vs 24,56 ± 7,5%. RESULTADOS: No grupo levosimendana, a duração do QRS diminuiu do valor basal para 116,47 ± 24,56 ms (p=0,006, enquanto não houve diferença significante no grupo dobutamina (p=0,605. Ambos os medicamentos causaram um aumento na FEVE, mas este foi significante apenas no grupo levosimendana (27,95 ± 8,9% p=0,003 vs 26,67 ± 7,6%, p=0,315. CONCLUSÃO: O estudo sugere que a administração de levosimendana, mas não de dobutamina, encurta a duração do QRS no ECG de superfície, possivelmente por causar uma contração coletiva nas fibras do músculo do ventrículo esquerdo. A base molecular desse efeito ainda precisa ser esclarecida.FUNDAMENTO: La levosimendana es un nuevo agente inotrópico que aumenta la contractibilidad cardíaca sin aumentar la captación celular de

  1. Oxidative stress in cardiovascular diseases

    Directory of Open Access Journals (Sweden)

    Shyamal K Goswami

    2015-01-01

    Full Text Available Oxidative stress caused by various oxygen containing free radicals and reactive species (collectively called "Reactive Oxygen Species" or ROS has long been attributed to cardiovascular diseases. In human body, major oxidizing species are super oxide, hydrogen peroxide, hydroxyl radical, peroxy nitrite etc. ROS are produced from distinct cellular sources, enzymatic and non-enzymatic; have specific physicochemical properties and often have specific cellular targets. Although early studies in nineteen sixties and seventies highlighted the deleterious effects of these species, later it was established that they also act as physiological modulators of cellular functions and diseases occur only when ROS production is deregulated. One of the major sources of cellular ROS is Nicotinamide adenine dinucleotide phosphate oxidases (Noxes that are expressed in almost all cell types. Superoxide and hydrogen peroxide generated from them under various conditions act as signal transducers. Due to their immense importance in cellular physiology, various Nox inhibitors are now being developed as therapeutics. Another free radical of importance in cardiovascular system is nitric oxide (a reactive nitrogen species generated from nitric oxide synthase(s. It plays a critical role in cardiac function and its dysregulated generation along with superoxide leads to the formation of peroxynitrite a highly deleterious agent. Despite overwhelming evidences of association between increased level of ROS and cardiovascular diseases, antioxidant therapies using vitamins and omega 3 fatty acids have largely been unsuccessful till date. Also, there are major discrepancies between studies with laboratory animals and human trials. It thus appears that the biology of ROS is far complex than anticipated before. A comprehensive understanding of the redox biology of diseases is thus needed for developing targeted therapeutics.

  2. Cardiovascular screening in Turner syndrome

    International Nuclear Information System (INIS)

    Dawson, K.L.; Wright, A.M.; Pitlick, P.T.

    1990-01-01

    This paper determines the utility of MR imaging as a cardiovascular screening method in patients with Turner syndrome and to compare its utility with that of echocardiography. Forty females with karytotypically proved Turner syndrome were prospectively evaluated with MR imaging and echocardiography. A 0.38-T resistive magnet was used to obtain ECG-gated axial and off-sagittal oblique images through the thorax with a spin-echo pulse sequence and TR 400--600 msec, TE 15--30 msec. Two-dimensional, M-mode, and Doppler echocardiography were performed and standard echocardiographic views were obtained

  3. Cell Therapy in Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Hoda Madani

    2014-05-01

    Full Text Available   Recently, cell therapy has sparked a revolution in ischemic heart disease that will in the future help clinicians to cure patients. Earlier investigations in animal models and clinical trials have suggested that positive paracrine effects such as neoangiogenesis and anti-apoptotic can improve myocardial function. In this regard the Royan cell therapy center designed a few trials in collaboration with multi hospitals such as Baqiyatallah, Shahid Lavasani, Tehran Heart Center, Shahid rajaee, Masih daneshvari, Imam Reza, Razavi and Sasan from 2006. Their results were interesting. However, cardiac stem cell therapy still faces great challenges in optimizing the treatment of patients. Keyword: Cardiovascular disease, Cell therapy.  

  4. Evolución del deterioro cognitivo y el nivel de dependencia en pacientes mayores de 65 años ingresados en un hospital de agudos: relación con las variables sociodemográficas

    Directory of Open Access Journals (Sweden)

    Mª José Calero-García

    2014-04-01

    Full Text Available El primer objetivo de este trabajo es establecer y estudiar la evolución de las etapas de deterioro cognitivo y los niveles de dependencia en pacientes mayores de 65 años, ingresados en un hospital de agudos, así como la relación entre estos dos factores y las diferentes variables demográficas. Los resultados muestran que el nivel de dependencia experimenta una caída repentina en el momento de la admisión, que evoluciona hacia una recuperación leve en el momento del alta, continuando esta recuperación en el domicilio posteriormente al alta, pero sin llegar a los niveles independentistas antes de la admisión. Además, se encontraron diferencias significativas en cuanto a edad, estado civil y nivel educativo. De una manera general, nuestros resultados proporcionan evidencia sobre el hecho de que las personas especialmente propensas al aumento de la dependencia funcional y el deterioro cognitivo severo durante el ingreso hospitalario son los ancianos hombres, mayores de 80 años de edad, sin estudios y viudos.

  5. O polimorfismo A1166C do receptor tipo 1 da angiotensina II no infarto agudo do miocárdio The A1166C polymorphism of the angiotensin II type-1 receptor in acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Messias Antônio de Araújo

    2004-11-01

    Full Text Available RESUMO OBJETIVO:Avaliar a associação do polimorfismo A1166C do gene do receptor AT1 da angiotensina II (AT1R com o infarto agudo do miocárdio e a severidade da doença arterial coronariana. MÉTODOS: Estudo prospectivo, transversal de 110 pacientes com infarto agudo do miocárdio submetidos à angiografia coronariana com lesão significante (> 50% avaliada por três critérios de severidade: número de vasos lesados, morfologia da placa aterosclerótica e escore de risco coronariano. Sem lesões coronarianas 104 indivíduos controles. O polimorfismo A1166C do gene do AT1R foi determinado pela reação em cadeia da polimerase no DNA dos leucócitos do sangue periférico. Os fatores de risco coronariano clássicos foram analisados em todos os indivíduos. RESULTADOS: Na estratificação dos genótipos em relação aos fatores de risco apenas o tabagismo teve predominância nos heterozigotos AC (p = 0,02. A freqüência dos genótipos nos pacientes infartados foi de AA = 54,5%; AC = 35,5% e CC = 10%, sendo similar e não significativa em relação aos controles (p = 0,83. Não houve aumento do risco de infarto agudo do miocárdio nas comparações dos genótipos CC vs AA (OR = 1,35; IC-95% = 0,50 - 3,59, AC vs AA (OR = 1,03; IC-95% = 0,58 - 1,84 e AA+AC vs AA (OR = 1,33; IC-95% = 0,51 - 3,45. Nenhum dos critérios de severidade teve associação significativa com os genótipos. CONCLUSÃO: Os nossos resultados indicam não haver associação do polimorfismo A1166C do AT1R com o infarto agudo do miocárdio e nem com a severidade da doença arterial coronariana segundo nossos resultados.OBJECTIVE: To assess the association of the A1166C polymorphism of the angiotensin II type-1 receptor (AT1R gene with acute myocardial infarction and also with the severity of coronary artery disease. METHODS: A prospective, cross-sectional study was carried out with 110 patients with acute myocardial infarction, who, on coronary angiography, had significant

  6. Influenza vaccines for preventing cardiovascular disease

    OpenAIRE

    Clar,Christine; Oseni,Zainab; Flowers,Nadine; Keshtkar-Jahromi,Maryam; Rees,Karen

    2015-01-01

    ABSTRACTBACKGROUND: This is an update of the original review published in 2008. The risk of adverse cardiovascular outcomes is increased with influenza-like infection, and vaccination against influenza may improve cardiovascular outcomes.OBJECTIVES: To assess the potential benefits of influenza vaccination for primary and secondary prevention of cardiovascular disease.METHODS:Search methods:We searched the following electronic databases on 18 October 2013: The Cochrane Library (including Coch...

  7. Association of diastolic blood pressure with cardiovascular events in older people varies upon cardiovascular history

    DEFF Research Database (Denmark)

    Wijsman, Liselotte W.; Muller, Majon; de Craen, Anton J .M.

    2018-01-01

    with those with normal DBP. After further adjusting for cardiovascular factors, this association attenuated to 1.05 (0.86; 1.28). A previous history of cardiovascular disease significantly modified the relation between DBP and risk of cardiovascular events (P-interaction 0.042). In participants without......BACKGROUND: In older age, a low DBP has been associated with increased risk of cardiovascular events, especially in frail older people. We tested the hypothesis that low DBP is associated with a high risk of cardiovascular events in people with a previous history of cardiovascular disease......-90 mmHg) or high (>90 mmHg). Cox proportional hazards analyses were used to estimate hazard ratio with 95% confidence intervals (CI); analyses were stratified for cardiovascular history. RESULTS: Participants with low DBP had a 1.24-fold (1.04; 1.49) increased risk of cardiovascular events compared...

  8. Increased susceptibility to cardiovascular effects of dihydrocapcaicin in resuscitated rats. Cardiovascular effects of dihydrocapsaicin

    DEFF Research Database (Denmark)

    Fosgerau, Keld; Ristagno, Giuseppe; Jayatissa, Magdalena Niepsuj

    2010-01-01

    Survivors of a cardiac arrest often have persistent cardiovascular derangements following cardiopulmonary resuscitation including decreased cardiac output, arrhythmias and morphological myocardial damage. These cardiovascular derangements may lead to an increased susceptibility towards the extern...

  9. Cardiovascular death and manic-depressive psychosis

    DEFF Research Database (Denmark)

    Weeke, A; Juel, K; Vaeth, M

    2013-01-01

    In order to study if tricyclic antidepressant drugs (TCA) in therapeutic doses increase the risk of death due to cardiovascular causes, the relative mortality from cardiovascular diseases was studied in two large groups of first hospitalized manic-depressive patients, one from the TCA era...... to the general population. Among 1133 such cases admitted between 1950 and 1956, the rate was 1.87. Our findings do not support the hypothesis that TCA contribute to the cardiovascular mortality in manic-depressives and even support suggestions that TCA treatment may lower the risk of death by cardiovascular...

  10. Sleep apnoea syndromes and the cardiovascular system.

    Science.gov (United States)

    Pepperell, Justin C

    2011-06-01

    Management of SAS and cardiovascular disease risk should be closely linked. It is important to screen for cardiovascular disease risk in patients with SAS and vice versa. CSA/CSR may be improved by ventilation strategies in heart failure, but benefit remains to be proven. For OSA, although CPAP may reduce cardiovascular disease risk, its main benefit is symptom control. In the longer-term, CPAP should be used alongside standard cardiovascular risk reduction strategies including robust weight management programmes, with referral for bariatric surgery in appropriate cases. CPAP and NIV should be considered for acute admissions with decompensated cardiac failure.

  11. Cardiovascular disease after cancer therapy

    Science.gov (United States)

    Aleman, Berthe M.P.; Moser, Elizabeth C.; Nuver, Janine; Suter, Thomas M.; Maraldo, Maja V.; Specht, Lena; Vrieling, Conny; Darby, Sarah C.

    2014-01-01

    Improvements in treatment and earlier diagnosis have both contributed to increased survival for many cancer patients. Unfortunately, many treatments carry a risk of late effects including cardiovascular diseases (CVDs), possibly leading to significant morbidity and mortality. In this paper we describe current knowledge of the cardiotoxicity arising from cancer treatments, outline gaps in knowledge, and indicate directions for future research and guideline development, as discussed during the 2014 Cancer Survivorship Summit organised by the European Organisation for Research and Treatment of Cancer (EORTC). Better knowledge is needed of the late effects of modern systemic treatments and of radiotherapy to critical structures of the heart, including the effect of both radiation dose and volume of the heart exposed. Research elucidating the extent to which treatments interact in causing CVD, and the mechanisms involved, as well as the extent to which treatments may increase CVD indirectly by increasing cardiovascular risk factors is also important. Systematic collection of data relating treatment details to late effects is needed, and great care is needed to obtain valid and generalisable results. Better knowledge of these cardiac effects will contribute to both primary and secondary prevention of late complications where exposure to cardiotoxic treatment is unavoidable. Also surrogate markers would help to identify patients at increased risk of cardiotoxicity. Evidence-based screening guidelines for CVD following cancer are also needed. Finally, risk prediction models should be developed to guide primary treatment choice and appropriate follow up after cancer treatment. PMID:26217163

  12. Dietary fat and cardiovascular disease?

    Directory of Open Access Journals (Sweden)

    Lie T. Merijanti

    2016-04-01

    Full Text Available Dietary saturated fat (SF intake has been shown to increase low density lipoprotein (LDL cholesterol and therefore has been associated with increased risk of cardiovascular disease (CVD. This evidence coupled with inferences from epidemiologic studies and clinical trials, had led to longstanding public health recommendations for limiting SF intake as a means of preventing CVD. However the relationship between SF and CVD risk remains controversial, due at least in part to the intrinsic limitations of clinical studies that have evaluated this relationship. A recent meta analysis showed that current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids (PUFA and low consumption of total SF. They found weak positive associations between circulating palmitic and stearic acids (found largely in palm oil and animal fats, respectively and CVD, whereas circulating margaric acid (a dairy fat significantly reduced the risk of CVD.(2,3 Saturated fat are not associated with all cause mortality, CVD, CHD, ischemic stroke or type 2 diabetes, but the evidence is heterogenous with methodological limitations.

  13. Marijuana Use and Cardiovascular Disease.

    Science.gov (United States)

    Franz, Christopher A; Frishman, William H

    2016-01-01

    Marijuana is currently the most used illicit substance in the world. With the current trend of decriminalization and legalization of marijuana in the US, physicians in the US will encounter more patients using marijuana recreationally over a diverse range of ages and health states. Therefore, it is relevant to review marijuana's effects on human cardiovascular physiology and disease. Compared with placebo, marijuana cigarettes cause increases in heart rate, supine systolic and diastolic blood pressures, and forearm blood flow via increased sympathetic nervous system activity. These actions increase myocardial oxygen demand to a degree that they can decrease the time to exercise-induced angina in patients with a history of stable angina. In addition, marijuana has been associated with triggering myocardial infarctions (MIs) in young male patients. Smoking marijuana has been shown to increase the risk of MI onset by a factor of 4.8 for the 60 minutes after marijuana consumption, and to increase the annual risk of MI in the daily cannabis user from 1.5% to 3% per year. Human and animal models suggest that this effect may be due to coronary arterial vasospasm. However, longitudinal studies have indicated that marijuana use may not have a significant effect on long-term mortality. While further research is required to definitively determine the impact of marijuana on cardiovascular disease, it is reasonable to recommend against recreational marijuana use, especially in individuals with a history of coronary artery disorders.

  14. Hormone Therapy and Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Fang-Ping Chen

    2006-12-01

    Full Text Available As in other Western countries, cardiovascular disease (CVD is the leading cause of death among women in Taiwan, exceeding the mortality from cervical or breast cancer. Women generally present with CVD after menopause and later than men, since menopause-related estrogen deficiency has been considered to be associated with an increased risk for CVD. Thus, coronary artery diseases and stroke are the two main contributors of mortality among postmenopausal women. Observational studies have reported a reduction in coronary artery disease risk after hormone therapy (HT ranging from 31-44%. However, recent randomized controlled trials that evaluated the effect of HT on primary and secondary CVD prevention have questioned the efficacy of HT, despite confirming the lipid-lowering effect of estrogen. However, a cluster of factors are responsible for the genesis and progression of CVD. Until we further evaluate their specific actions and how these different factors interact, the issue related to HT and cardiovascular risk will remain unsettled. Since these studies have contributed to our understanding of the benefits and risks associated with HT, HT use should be individualized after consideration of the condition of each postmenopausal patient. Ideally, the efficacy of different preparations and dosages of HT in postmenopausal women who are at risk of CVD, before atheromatous lesions have developed, should be investigated.

  15. Modelo del Costo Basado en la Actividad aplicado a consultas por trazadores de enfermedades cardiovasculares

    Directory of Open Access Journals (Sweden)

    Marteau Silvia A.

    2001-01-01

    Full Text Available OBJETIVO: Hacer un análisis de costos, de la atención médica en consultas externas, mediante la metodología del Costo Basado en la Actividad (ABC, por sus siglas en inglés y en relación con eventos trazadores de enfermedades cardiovasculares de origen isquémico en las instituciones del sector público. MATERIAL Y MÉTODOS: El estudio se basó en consultas por enfermedades o eventos trazadores (n=290 y no trazadores (n=1 710, de una muestra de 2 000 consultas de primera vez de un hospital zonal general de agudos (San Roque de Gonnet, de la provincia de Buenos Aires, Argentina, y se realizó de abril a octubre de 1998. El costo se evaluó con la metodología del ABC. RESULTADOS: El mejoramiento de las actividades de atención en el servicio de Clínica Médica conllevaría un ahorro sustancial en los costos indirectos, equivalente a un porcentaje promedio de 7.11 sobre los productos definidos como consultas por hipertensión arterial (HTA, dislipidemia y diabetes. El ahorro total en el costo unitario por producto que se produciría si se eliminaran las actividades mencionadas, estaría en el orden de 11.78% para el producto HTA, de 13.96% para dislipidemia, de 19.05% para diabetes y de 11.45% para las enfermedades no trazadores. Se asignó o se gastó ineficientemente 66.26% de los costos totales indirectos correspondientes al producto dislipidemia y 61.80% de los correspondientes a diabetes. El costo unitario total de las consultas en el servicio de Clínica Médica, según el método tradicional, es de $22.98, valor que en algunos casos está muy por debajo del costo obtenido a partir del método ABC aplicado en este estudio. CONCLUSIONES: Es necesario trabajar en el rediseño del proceso de atención para evaluar las actividades que no agreguen valor al mismo; éstas únicamente generan molestias y demoras al paciente y provocan ineficiencias en el sistema, dado que se asignan recursos a actividades que no optimizan la gestión y, como

  16. [Quality management in cardiovascular echography].

    Science.gov (United States)

    Gullace, Giuseppe

    2002-12-01

    The quality management of an organization can be defined as the ability to identify, plan and implement programs of measure, analysis, verification and control that allow to monitor management, resources, activities, processes and output/outcome of the same organization, including the satisfaction of the customers. Whatever the model used, it is demonstrated that the management-quality system, either for professional quality or for organization, turns out to be effective even in the health organizations within and to any level of organizational-structural complexity. The present paper concerns the experience of the Italian Society of Cardiovascular Echography (SIEC) on quality certification, both as a scientific society compared to other health organizations and to cardiovascular echo laboratories, and the definition of minimum requirements for the accreditation of the same laboratories. The model most frequently used for quality management is represented by the ISO 9000: Vision 2000, that is a management model with specific reference to the organization and the customer satisfaction. The model applied to the health structure needs a rapid change in mentality that addresses the operators to define, share and achieve objectives to be brought on by means of an active collaboration, group activity and deep sense of belonging necessary to the attainment of expected objectives. When the model is applied by a scientific society, it is necessary to take into account the different structural and functional organization, the constitution and the operators differing on the point of view of origin, experiences, mentality, and roles. The ISO 9000: Vision 2000 model can be applied also to the cardiovascular echo laboratory which may be compared to a simple organization; for its corrected functioning, SIEC has defined minimal requirements for the accreditation, realization and modalities to carry out and manage quality. The quality system represents a new way of operating of an

  17. Improving risk stratification for cardiovascular disease

    NARCIS (Netherlands)

    van Wijk, Diederik F.; Boekholdt, S. Matthijs

    2010-01-01

    Evaluation of: Heslop CL, Frohlich JJ, Hill JS. Myeloperoxidase and C-reactive protein have combined utility for long-term prediction of cardiovascular mortality after coronary angiography. J. Am. Coll. Cardiol. 55(11), 1102-1109 (2010). Identifying people at high risk of cardiovascular events is

  18. Unmet needs for cardiovascular care in Indonesia.

    Directory of Open Access Journals (Sweden)

    Asri Maharani

    Full Text Available In the past twenty years the heaviest burden of cardiovascular diseases has begun to shift from developed to developing countries. However, little is known about the real needs for cardiovascular care in these countries and how well those needs are being met. This study aims to investigate the prevalence and determinants of unmet needs for cardiovascular care based on objective assessment.Multilevel analysis is used to analyse the determinants of met needs and multilevel multiple imputation is applied to manage missing data. The 2008 Indonesian Family Life Survey (IFLS4 survey is the source of the household data used in this study, while district data is sourced from the Ministry of Health and Ministry of Finance. The data shows that nearly 70% of respondents with moderate to high cardiovascular risk failed to receive cardiovascular care. Higher income, possession of health insurance and residence in urban areas are significantly associated with met needs for cardiovascular care, while health facility density and physician density show no association with them.The prevalence of unmet needs for cardiovascular care is considerable in Indonesia. Inequality persists as a factor in meeting needs for cardiovascular care as the needs of people with higher incomes and those living in urban areas are more likely to be met. Alleviation of poverty, provision of health care insurance for the poor, and improvement in the quality of healthcare providers are recommended in order to meet this ever-increasing need.

  19. Cardiovascular Parameters of Nigerian Physiotherapy Students Dur ...

    African Journals Online (AJOL)

    Examination and tests are routine academic task during which students engage in mental exercis-es, writing, and/or practical demonstrations under pressure with stress placed on the cardiovascu-lar system. This study was aimed at investigating the cardiovascular parameters of students before, during and after an ...

  20. Oral temperature and cardiovascular responses of apparently ...

    African Journals Online (AJOL)

    Oral temperature and cardiovascular responses of apparently healthy subjects to passive and active warm-up. BOA Adegoke, OO Ogwumike, FA Maruf. Abstract. This study investigated and compared the effects of active and passive warm-up on oral temperature and cardiovascular parameters of forty (20 males and 20 ...

  1. Hepatitis C virus and cardiovascular: A review

    Directory of Open Access Journals (Sweden)

    Salvatore Petta

    2017-03-01

    Full Text Available Chronic hepatitis C virus (HCV infection is a systemic disease that leads to increased risks of cirrhosis and its complications, as well as extrahepatic disturbances, including immune-related disorders and metabolic alterations such as insulin resistance and steatosis. Recent accumulating evidence suggests that HCV infection can increase cardiovascular risk, and that viral eradication can improve cardiovascular outcomes in the clinical setting. These data are strengthened by evidence identifying potential mechanisms (indirectly linking HCV infection to vascular damage. However, the high prevalence of both HCV infection and cardiovascular alterations, as well as the presence of contrasting results not identifying any association between HCV infection and cardiovascular dysfunction, provides uncertainty about a direct association of HCV infection with cardiovascular risk. Further studies are needed to clarify definitively the role of HCV infection in cardiovascular alterations, as well as the impact of viral eradication on cardiovascular outcomes. These features are now more attractive, considering the availability of new, safe, and very effective interferon-free antiviral agents for the treatment of HCV infection. This review aims to discuss carefully available data on the relationship between HCV infection and cardiovascular risk.

  2. Cardiovascular Ultrasound of Neonatal Long Evans Rats ...

    Science.gov (United States)

    This abstract describes the use of a relatively new technology, cardiovascular ultrasound (echocardiography) for evaluating developmental toxicity affecting heart development. The abstract describes the effects of two known cardiac teratogens, trichloroacetic acid and dimethadione, and their effects as determined by echocardiography. This abstract describes the use and development of a relatively new technology, cardiovascular ultrasound (echocardiography) for evaluating developmental toxicity affecting heart development.

  3. Cardiovascular Disease and Cancer: Student Awareness Activities.

    Science.gov (United States)

    Meyer, James H., Comp.

    Awareness activities pertaining to cancer and cardiovascular disease are presented as a supplement for high school science classes. The exercises can be used to enrich units of study dealing with the circulatory system, the cell, or human diseases. Eight activities deal with the following topics: (1) cardiovascular disease risk factors; (2)…

  4. Unmet needs for cardiovascular care in Indonesia.

    Science.gov (United States)

    Maharani, Asri; Tampubolon, Gindo

    2014-01-01

    In the past twenty years the heaviest burden of cardiovascular diseases has begun to shift from developed to developing countries. However, little is known about the real needs for cardiovascular care in these countries and how well those needs are being met. This study aims to investigate the prevalence and determinants of unmet needs for cardiovascular care based on objective assessment. Multilevel analysis is used to analyse the determinants of met needs and multilevel multiple imputation is applied to manage missing data. The 2008 Indonesian Family Life Survey (IFLS4) survey is the source of the household data used in this study, while district data is sourced from the Ministry of Health and Ministry of Finance. The data shows that nearly 70% of respondents with moderate to high cardiovascular risk failed to receive cardiovascular care. Higher income, possession of health insurance and residence in urban areas are significantly associated with met needs for cardiovascular care, while health facility density and physician density show no association with them. The prevalence of unmet needs for cardiovascular care is considerable in Indonesia. Inequality persists as a factor in meeting needs for cardiovascular care as the needs of people with higher incomes and those living in urban areas are more likely to be met. Alleviation of poverty, provision of health care insurance for the poor, and improvement in the quality of healthcare providers are recommended in order to meet this ever-increasing need.

  5. Diabetes propels the risk for cardiovascular disease

    NARCIS (Netherlands)

    Diepen, van Janna A.; Thiem, Kathrin; Stienstra, Rinke; Riksen, Niels P.; Tack, Cees J.; Netea, Mihai G.

    2016-01-01

    Diabetes strongly predisposes to cardiovascular disease (CVD), the leading cause of mortality in these patients, as well as in the entire population. Hyperglycemia is an important cardiovascular risk factor as shown by the observation that even transient periods of hyperglycemia, despite return

  6. Detection of cardiovascular anomalies: Hybrid systems approach

    KAUST Repository

    Ledezma, Fernando

    2012-06-06

    In this paper, we propose a hybrid interpretation of the cardiovascular system. Based on a model proposed by Simaan et al. (2009), we study the problem of detecting cardiovascular anomalies that can be caused by variations in some physiological parameters, using an observerbased approach. We present the first numerical results obtained. © 2012 IFAC.

  7. Coffee and cardiovascular risk; an epidemiological study

    NARCIS (Netherlands)

    A.A.A. Bak (Annette)

    1990-01-01

    textabstractThis thesis comprises several studies on the effect of coffee and caffeine on cardiovascular risk in general, and the effect on serum lipids, blood pressure and selected hemostatic variables in particular. The association between coffee use and cardiovascular morbidity and

  8. Acute lung injury induces cardiovascular dysfunction

    DEFF Research Database (Denmark)

    Suda, Koichi; Tsuruta, Masashi; Eom, Jihyoun

    2011-01-01

    Acute lung injury (ALI) is associated with systemic inflammation and cardiovascular dysfunction. IL-6 is a biomarker of this systemic response and a predictor of cardiovascular events, but its possible causal role is uncertain. Inhaled corticosteroids and long-acting β2 agonists (ICS/LABA) down-r...

  9. Preeclampsia: at risk for remote cardiovascular disease

    NARCIS (Netherlands)

    Harskamp, Ralf E.; Zeeman, Gerda G.

    2007-01-01

    Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to

  10. Preeclampsia : At risk for remote cardiovascular disease

    NARCIS (Netherlands)

    Harskamp, Ralf E.; Zeeman, Gerda G.

    2007-01-01

    Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to

  11. Cardiovascular Reactivity, Stress, and Physical Activity

    Directory of Open Access Journals (Sweden)

    Chun-Jung eHuang

    2013-11-01

    Full Text Available Psychological stress has been proposed as a major contributor to the progression of cardiovascular disease (CVD. Acute mental stress can activate the sympathetic-adrenal-medullary (SAM axis, eliciting the release of catecholamines (NE and EPI resulting in the elevation of heart rate (HR and blood pressure (BP. Combined stress (psychological and physical can exacerbate these cardiovascular responses, which may partially contribute to the elevated risk of CVD and increased proportionate mortality risks experienced by some occupations (e.g., firefighting and law enforcement. Studies have supported the benefits of physical activity on physiological and psychological health, including the cardiovascular response to acute stress. Aerobically trained individuals exhibit lower sympathetic nervous system (e.g., HR reactivity and enhanced cardiovascular efficiency (e.g., lower vascular reactivity and decreased recovery time in response to physical and/or psychological stress. In addition, resistance training has been demonstrated to attenuate cardiovascular responses and improve mental health. This review will examine stress-induced cardiovascular reactivity and plausible explanations for how exercise training and physical fitness (aerobic and resistance exercise can attenuate cardiovascular responses to stress. This enhanced functionality may facilitate a reduction in the incidence of stroke and myocardial infarction. Finally, this review will also address the interaction of obesity and physical activity on cardiovascular reactivity and CVD.

  12. Genetic influences on cardiovascular stress reactivity

    NARCIS (Netherlands)

    Wu, Ting; Snieder, Harold; de Geus, Eco

    Individual differences in the cardiovascular response to stress play a central role in the reactivity hypothesis linking frequent exposure to psychosocial stress to adverse outcomes in cardiovascular health. To assess the importance of genetic factors, a meta-analysis was performed on all published

  13. Depression: risk factor for cardiovascular disease

    NARCIS (Netherlands)

    Kuehl, L.K.; Penninx, B.W.J.H.; Otte, C.

    2012-01-01

    Major depression is an independent risk factor for the development of cardiovascular disease. In patients with existing cardiovascular disease, major depression has a large impact on the quality of life and is associated with a poor course and prognosis. Potential mechanisms responsible for this

  14. Cardiovascular Risk Factors in Airline Pilots.

    Science.gov (United States)

    Lord, Dana; Conlon, Helen Acree

    2018-02-01

    The health of an airline pilot is imperative to the safe travels of millions of people worldwide. Medical providers evaluate the cardiovascular risks for airline pilots and the medical requirements to obtain and maintain licensure as an airline pilot. It is the role of the occupational health nurse practitioner to evaluate and reduce the risk of cardiovascular disease in this population.

  15. Retrospective monitoring of drug utilisation in cardiovascular ...

    African Journals Online (AJOL)

    This retrospective study was carried out to established drug prescribing trends in the management of cardiovascular diseases (CVDs) in the cardiovascular unit of the Department of Medicine, University of Port Harcourt Teaching Hospital, Rivers State, Nigeria. 100 folders of patients with various CVDs were randomly ...

  16. Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Jie Wang

    2015-01-01

    Full Text Available Recent studies demonstrated that mitochondria play an important role in the cardiovascular system and mutations of mitochondrial DNA affect coronary artery disease, resulting in hypertension, atherosclerosis, and cardiomyopathy. Traditional Chinese medicine (TCM has been used for thousands of years to treat cardiovascular disease, but it is not yet clear how TCM affects mitochondrial function. By reviewing the interactions between the cardiovascular system, mitochondrial DNA, and TCM, we show that cardiovascular disease is negatively affected by mutations in mitochondrial DNA and that TCM can be used to treat cardiovascular disease by regulating the structure and function of mitochondria via increases in mitochondrial electron transport and oxidative phosphorylation, modulation of mitochondrial-mediated apoptosis, and decreases in mitochondrial ROS. However further research is still required to identify the mechanism by which TCM affects CVD and modifies mitochondrial DNA.

  17. Vitamin D, cardiovascular disease and risk factors

    DEFF Research Database (Denmark)

    Skaaby, Tea; Thuesen, Betina H.; Linneberg, Allan

    2017-01-01

    of vitamin D effects from a cardiovascular health perspective. It focuses on vitamin D in relation to cardiovascular disease, i.e. ischemic heart disease, and stroke; the traditional cardiovascular risk factors hypertension, abnormal blood lipids, obesity; and the emerging risk factors hyperparathyroidism......, microalbuminuria, chronic obstructive pulmonary diseases, and non-alcoholic fatty liver disease. Meta-analyses of observational studies have largely found vitamin D levels to be inversely associated with cardiovascular risk and disease. However, Mendelian randomization studies and randomized, controlled trials...... (RCTs) have not been able to consistently replicate the observational findings. Several RCTs are ongoing, and the results from these are needed to clarify whether vitamin D deficiency is a causal and reversible factor to prevent cardiovascular disease....

  18. The gut microbiome in atherosclerotic cardiovascular disease

    DEFF Research Database (Denmark)

    Jie, Zhuye; Xia, Huihua; Zhong, Shi-Long

    2017-01-01

    The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals...... with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular......), with liver cirrhosis, and rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases.The gut microbiota may play a role in cardiovascular diseases. Here, the authors perform...

  19. Oral Antidiabetic Agents and Cardiovascular Outcomes

    DEFF Research Database (Denmark)

    Pareek, Manan; Bhatt, Deepak L

    2018-01-01

    Cardiovascular disease is the leading cause of morbidity and mortality among patients with type 2 diabetes; however, a direct protective effect of tight glycemic control remains unproven. In fact, until 2008, when concerns related to rosiglitazone prompted regulatory agencies to mandate assessment...... of cardiovascular safety of new antidiabetic agents, little was known about how these medications affected cardiovascular outcomes. Since then, there has been a considerable increase in the number of cardiovascular trials, which employ a noninferiority design and focus on high-risk populations to establish safety...... in the shortest time possible. In this article, we summarize the 4 major cardiovascular outcome trials of oral antidiabetic agents, completed so far. These include 3 dipeptidyl peptidase-4 inhibitors (saxagliptin, alogliptin, and sitagliptin) and 1 sodium-glucose cotransporter-2 inhibitor (empagliflozin). We...

  20. Maintained intentional weight loss reduces cardiovascular outcomes

    DEFF Research Database (Denmark)

    Caterson, I D; Finer, N; Coutinho, W

    2012-01-01

    Aim: The Sibutramine Cardiovascular OUTcomes trial showed that sibutramine produced greater mean weight loss than placebo but increased cardiovascular morbidity but not mortality. The relationship between 12-month weight loss and subsequent cardiovascular outcomes is explored. Methods: Overweight....../obese subjects (N = 10 744), =55 years with cardiovascular disease and/or type 2 diabetes mellitus, received sibutramine plus weight management during a 6-week Lead-in Period before randomization to continue sibutramine (N = 4906) or to receive placebo (N = 4898). The primary endpoint was the time from...... randomization to first occurrence of a primary outcome event (non-fatal myocardial infarction, non-fatal stroke, resuscitated cardiac arrest or cardiovascular death). Results: For the total population, mean weight change during Lead-in Period (sibutramine) was -2.54 kg. Post-randomization, mean total weight...

  1. Racism and cardiovascular disease: implications for nursing.

    Science.gov (United States)

    Jackson, Jennifer; McGibbon, Elizabeth; Waldron, Ingrid

    2013-01-01

    The social determinants of health (SDH) are recognized as a prominent influence on health outcomes across the lifespan. Racism is identified as a key SDH. In this article, the authors describe the concept of racism as an SDH, its impact in discriminatory actions and inactions, and the implications for cardiovascular nurses. Although research in Canada on the links among racism, stress, and cardiovascular disease is limited, there is growing evidence about the stress of racism and its long-term impact on cardiovascular health. The authors discuss how cardiovascular nursing could be enhanced through an understanding of racism-related stress, and race-based differences in cardiovascular care. The authors conclude with strategies for action to address this nursing concern.

  2. Cardiovascular evaluation of lowland gorillas

    International Nuclear Information System (INIS)

    Junge, R.E.; Mezei, L.E.; Muhlbauer, M.C.; Weber, M.

    1998-01-01

    To design a diagnostic protocol that uses appropriate techniques, including ultrasonography, to assess cardiovascular health and detect primary cardiac diseases in gorillas and to establish a database of reference values for cardiac measurements in clinically normal gorillas. Prospective study. 5 adult male lowland gorillas from 11 to 18 years old. A complete cardiac evaluation was performed on anesthetized gorillas, including physical examination, thoracic radiography, electrocardiography, echocardiography, blood pressure determination, CBC, serum biochemical analyses, and serologic assay for viral diseases. Standard cardiac measurements were made from images collected during ultrasonography. Cardiac measurements derived from ultrasonographic images were consistent with those considered normal in human beings. Results of other diagnostic tests were also considered normal. Cardiac disease is the primary cause of mortality in old captive gorillas. The technique used here provided excellent evaluation of cardiac function. Use of these techniques will allow early detection of cardiac disease, making treatment or medical management possible

  3. Cardiovascular Benefits of Dark Chocolate?

    Science.gov (United States)

    Higginbotham, Erin; Taub, Pam R

    2015-12-01

    The use of cacao for health benefits dates back at least 3000 years. Our understanding of cacao has evolved with modern science. It is now felt based on extensive research the main health benefits of cacao stem from epicatechin, a flavanol found in cacao. The process of manufacturing dark chocolate retains epicatechin, whereas milk chocolate does not contain significant amounts of epicatechin. Thus, most of the current research studies are focused on dark chocolate. Both epidemiological and clinical studies suggest a beneficial effect of dark chocolate on blood pressure, lipids, and inflammation. Proposed mechanisms underlying these benefits include enhanced nitric oxide bioavailability and improved mitochondrial structure/function. Ultimately, further studies of this promising compound are needed to elucidate its potential for prevention and treatment of cardiovascular and metabolic diseases as well as other diseases that have underlying mechanisms of mitochondrial dysfunction and nitric oxide deficiency.

  4. Understanding changes in cardiovascular pathophysiology.

    Science.gov (United States)

    Chummun, Harry

    Cardiovascular pathophysiological changes, such as hypertension and enlarged ventricles, reflect the altered functions of the heart and its circulation during ill-health. This article examines the normal and altered anatomy of the cardiac valves, the contractile elements and enzymes of the myocardium, the significance of the different factors associated with cardiac output, and the role of the autonomic nervous system in the heart beat. It also explores how certain diseases alter these functions and result in cardiac symptoms. Nurses can benefit from knowledge of these specific changes, for example, by being able to ask relevant questions in order to ascertain the nature of a patients condition, by being able to take an effective patient history and by being able to read diagnostic results, such as electrocardiograms and cardiac enzyme results. All this will help nurses to promote sound cardiac care based on a physiological rationale.

  5. Factores emocionales en el abordaje de las enfermedades cardiovasculares. Valoración actualizada desde la Psicocardiología Emotional Factors in the present a topic of Cardiovascular Diseases. Updated Assessment from Psychocardiology

    Directory of Open Access Journals (Sweden)

    Teresa Rodríguez Rodríguez

    2012-11-01

    Full Text Available El tratamiento de las enfermedades cardiovasculares exige un abordaje desde la multidisciplinariedad, por la presencia de diversos factores en su origen y evolución. La Psicocardiología se encarga de estudiar los factores de orden psicológico vinculados a estas enfermedades. En el presente trabajo se abordan los factores emocionales que repercuten en diferentes padecimientos coronarios, así como el vínculo de estos, con los diferentes tipos de personalidad. Se exponen resultados obtenidos sobre el estudio de diversas emociones en pacientes portadores de infarto agudo del miocardio en fase aguda, y se ilustra cómo realizar la intervención psicológica para lograr el control emocional de estos pacientes porque puede ser útil para los enfermos y en el mejoramiento del cuadro clínico en general. Finalmente se apela a la necesidad de crear una concientización en la comunidad médica, para que no se desestime el papel de factores de índole subjetiva a la hora de prevenir, diagnosticar y tratar cualquier enfermedad cardiaca.The treatment of cardiovascular diseases requires an approach from a variety of disciplines due to the presence of several factors in its origins and evolution. Psychocardiology is responsible for studying the factors related to psychology associated with these diseases. This paper addresses the emotional factors affecting different coronary heart diseases, as well as the link among them, with different types of personalities. Results on the study of various emotions in patients with acute myocardial infarction in the acute phase are presented and it is illustrates how to achieve psychological intervention for emotional control in these patients because it can be useful for them in the improvement of the overall clinical condition. Finally, it is appealed to the need of creating an awareness in the medical community not to discard the role of subjectivity when it comes to preventing, diagnosing and treating any cardiac

  6. Physiological Changes to the Cardiovascular System at High Altitude and Its Effects on Cardiovascular Disease.

    Science.gov (United States)

    Riley, Callum James; Gavin, Matthew

    2017-06-01

    Riley, Callum James, and Matthew Gavin. Physiological changes to the cardiovascular system at high altitude and its effects on cardiovascular disease. High Alt Med Biol. 18:102-113, 2017.-The physiological changes to the cardiovascular system in response to the high altitude environment are well understood. More recently, we have begun to understand how these changes may affect and cause detriment to cardiovascular disease. In addition to this, the increasing availability of altitude simulation has dramatically improved our understanding of the physiology of high altitude. This has allowed further study on the effect of altitude in those with cardiovascular disease in a safe and controlled environment as well as in healthy individuals. Using a thorough PubMed search, this review aims to integrate recent advances in cardiovascular physiology at altitude with previous understanding, as well as its potential implications on cardiovascular disease. Altogether, it was found that the changes at altitude to cardiovascular physiology are profound enough to have a noteworthy effect on many forms of cardiovascular disease. While often asymptomatic, there is some risk in high altitude exposure for individuals with certain cardiovascular diseases. Although controlled research in patients with cardiovascular disease was largely lacking, meaning firm conclusions cannot be drawn, these risks should be a consideration to both the individual and their physician.

  7. Cardiovascular risk factors in outpatients with bipolar disorder

    NARCIS (Netherlands)

    Klumpers, U.M.H.; Boom, K.; Janssen, F.M.G.; Tulen, J.H.M.; Loonen, Anton J. M.

    2004-01-01

    Background: The mortality due to cardiovascular diseases in bipolar patients is much higher than in the general population. It is unclear whether lithium treatment contributes to this cardiovascular morbidity. Methods: The cardiovascular risk factors in outpatients with bipolar disorder on

  8. Plausible mechanisms explaining the association of periodontitis with cardiovascular diseases

    NARCIS (Netherlands)

    Loos, B.G.; Teeuw, W.J.; Nicu, E.A.; Lynge Petersen, A.M.

    2016-01-01

    The association between periodontitis and cardiovascular diseases is now well established. Cardiovascular diseases include atherosclerosis, coronary heart (artery) disease, cerebrovascular disease, and peripheral artery disease. Atherosclerosis is the underlying pathology of cardiovascular diseases.

  9. Cardiovascular risk prediction in chronic kidney disease patients

    Directory of Open Access Journals (Sweden)

    Santiago Cedeño Mora

    2017-05-01

    Conclusion: The cardiovascular risk scores (FRS-CVD and ASCVD [AHA/ACC 2013] can estimate the probability of atherosclerotic cardiovascular events in patients with CKD regardless of renal function, albuminuria and previous cardiovascular events.

  10. Cardiovascular risk factors and dementia.

    Science.gov (United States)

    Fillit, Howard; Nash, David T; Rundek, Tatjana; Zuckerman, Andrea

    2008-06-01

    Dementias, such as Alzheimer's disease (AD) and vascular dementia, are disorders of aging populations and represent a significant economic burden. Evidence is accumulating to suggest that cardiovascular disease (CVD) risk factors may be instrumental in the development of dementia. The goal of this review was to discuss the relationship between specific CVD risk factors and dementia and how current treatment strategies for dementia should focus on reducing CVD risks. We conducted a review of the literature for the simultaneous presence of 2 major topics, cardiovascular risk factors and dementia (eg, AD). Special emphasis was placed on clinical outcome studies examining the effects of treatments of pharmacologically modifiable CVD risk factors on dementia and cognitive impairment. Lifestyle risk factors for CVD, such as obesity, lack of exercise, smoking, and certain psychosocial factors, have been associated with an increased risk of cognitive decline and dementia. Some evidence suggests that effectively managing these factors may prevent cognitive decline/dementia. Randomized, placebo-controlled trials of antihypertensive medications have found that such therapy may reduce the risk of cognitive decline, and limited data suggest a benefit for patients with AD. Some small open-label and randomized clinical trials of statins have observed positive effects on cognitive function; larger studies of statins in patients with AD are ongoing. Although more research is needed, current evidence indicates an association between CVD risk factors--such as hypertension, dyslipidemia, and diabetes mellitus--and cognitive decline/dementia. From a clinical perspective, these data further support the rationale for physicians to provide effective management of CVD risk factors and for patients to be compliant with such recommendations to possibly prevent cognitive decline/dementia.

  11. Mortality of mothers from cardiovascular and non-cardiovascular causes following pregnancy complications in first delivery

    DEFF Research Database (Denmark)

    Lykke, Jacob Alexander; Langhoff-Roos, Jens; Lockwood, Charles J

    2010-01-01

    The combined effects of preterm delivery, small-for-gestational-age offspring, hypertensive disorders of pregnancy, placental abruption and stillbirth on early maternal death from cardiovascular causes have not previously been described in a large cohort. We investigated the effects of pregnancy...... cardiovascular and non-cardiovascular causes following preterm delivery, small-for-gestational-age offspring and hypertensive disorders of pregnancy. We found that preterm delivery and small-for-gestational-age were both associated with subsequent death of mothers from cardiovascular and non......-cardiovascular causes. Severe pre-eclampsia was associated with death from cardiovascular causes only. There was a less than additive effect on cardiovascular mortality hazard ratios with increasing number of pregnancy complications: preterm delivery 1.90 [95% confidence intervals 1.49, 2.43]; preterm delivery...

  12. HIV INFECTION, ANTIRETROVIRAL THERAPY AND CARDIOVASCULAR RISK

    Directory of Open Access Journals (Sweden)

    Katleen de Gaetano Donati

    2010-11-01

    Full Text Available In the last 15 years, highly active antiretroviral therapy (HAART has determined a dramatic reduction of both morbidity and mortality in human immunodeficiency virus (HIV-infected subjects, transforming this infection in a chronic and manageable disease. Patients surviving with HIV in the developed world, in larger number men,  are becoming aged. As it would be expected for a population of comparable age, many HIV-infected individuals report a family history of cardiovascular disease, a small proportion have already experienced a cardiovascular event and an increasing proportion has diabetes mellitus. Smoking rate is very high while an increasing proportion of HIV-infected individuals have dyslipidaemia. Studies suggest that these traditional risk factors could play an important  role in the development of cardiovascular disease in these patients as they do in the general population. Thus, whilst the predicted 10-year cardiovascular disease risk remains relatively low at present, it will likely increase in relation to the progressive aging of  this patient population. Thus, the long-term follow-up of HIV infected patients has to include co-morbidity management such as cardiovascular disease prevention and treatment. Two intriguing aspects related to the cardiovascular risk in patients with HIV infection are the matter of current investigation: 1 while these subjects share many cardiovascular risk factors with the general population, HIV infection itself increases cardiovascular risk; 2 some HAART regimens too influence atherosclerotic profile, partly due to lipid changes. Although the mechanisms involved in the development of cardiovascular complications in HIV-infected patients remain to be fully elucidated, treatment guidelines recommending interventions to prevent cardiovascular disease in these individuals are already available; however, their application is still limited.

  13. Cardiovascular risk profile in women and dementia.

    Science.gov (United States)

    Dufouil, Carole; Seshadri, Sudha; Chêne, Geneviève

    2014-01-01

    There is growing evidence for the importance of cardiovascular risk factors in dementia development, including Alzheimer's disease. As cardiovascular risk profiles vary greatly by gender, with men suffering a greater burden of cardiovascular risk in midlife, this could lead to differences in dementia risk. To explore current evidence on the association between components of the cardiovascular risk profile and dementia risk in women and men, we reviewed all studies reporting the risk of dementia associated with cardiovascular risk factors stratified by gender and found 53 eligible articles out of over 4,000 published since the year 2000. Consistent results were found: 1) for exposures acting specifically in women: Overweight/obesity (harmful) and physical activity (protective), and 2) for exposures acting similarly in women and men: Moderate alcohol (protective) and hypertension, diabetes, and depression (harmful). A modified effect of tobacco or high cholesterol/statin use remained controversial. Available data do not allow us to assess whether selection of men with healthier cardiovascular profile (due to cardiovascular death in midlife) could lead in late life either to a difference in the distribution of risk factors or to a differential effect of these risk factors by gender. We recommend that results on dementia risk factors, especially cardiovascular ones, be reported systematically by gender in all future studies. More generally, as cardiovascular risk profiles evolve over time, more attention needs to be paid to the detection and correction of cardiovascular risk factors, as early as possible in the life course, and as actively in women as in men.

  14. Non-cardiovascular findings in clinical cardiovascular magnetic resonance imaging in children

    International Nuclear Information System (INIS)

    Ghadimi Mahani, Maryam; Morani, Ajaykumar C.; Lu, Jimmy C.; Dorfman, Adam L.; Fazeli Dehkordy, Soudabeh; Jeph, Sunil; Agarwal, Prachi P.

    2016-01-01

    With increasing use of pediatric cardiovascular MRI, it is important for all imagers to become familiar with the spectrum of non-cardiovascular imaging findings that can be encountered. This study aims to ascertain the prevalence and nature of these findings in pediatric cardiovascular MRIs performed at our institution. We retrospectively evaluated reports of all cardiovascular MRI studies performed at our institute from January 2008 to October 2012 in patients younger than18 years. Most studies (98%) were jointly interpreted by a pediatric cardiologist and a radiologist. We reviewed the electronic medical records of all cases with non-cardiovascular findings, defined as any imaging finding outside the cardiovascular system. Non-cardiovascular findings were classified into significant and non-significant, based on whether they were known at the time of imaging or they required additional workup or a change in management. In 849 consecutive studies (mean age 9.7 ± 6.3 years), 145 non-cardiovascular findings were found in 140 studies (16.5% of total studies). Overall, 51.0% (74/145) of non-cardiovascular findings were in the abdomen, 30.3% (44/145) were in the chest, and 18.6% (27/145) were in the spine. A total of 19 significant non-cardiovascular findings were observed in 19 studies in individual patients (2.2% of total studies, 47% male, mean age 5.9 ± 6.7 years). Significant non-cardiovascular findings included hepatic adenoma, arterially enhancing focal liver lesions, asplenia, solitary kidney, pelvicaliectasis, renal cystic diseases, gastric distention, adrenal hemorrhage, lung hypoplasia, air space disease, bronchial narrowing, pneumomediastinum and retained surgical sponge. Non-cardiovascular findings were seen in 16.5% of cardiovascular MRI studies in children, of which 2.2% were clinically significant findings. Prevalence and nature of these non-cardiovascular findings are different from those reported in adults. Attention to these findings is important

  15. Non-cardiovascular findings in clinical cardiovascular magnetic resonance imaging in children

    Energy Technology Data Exchange (ETDEWEB)

    Ghadimi Mahani, Maryam [University of Michigan Health System, C.S. Mott Children' s Hospital, Department of Radiology, Section of Pediatric Radiology, Ann Arbor, MI (United States); Morani, Ajaykumar C. [The University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Houston, TX (United States); Lu, Jimmy C.; Dorfman, Adam L. [University of Michigan Health System, C.S. Mott Children' s Hospital, Department of Pediatrics and Communicable Diseases, Division of Pediatric Cardiology, Ann Arbor, MI (United States); Fazeli Dehkordy, Soudabeh [University of Michigan Health System, C.S. Mott Children' s Hospital, Department of Radiology, Section of Pediatric Radiology, Ann Arbor, MI (United States); Providence Hospital and Medical Centers, Department of Graduate Medical Education, Southfield, MI (United States); Jeph, Sunil [The University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Houston, TX (United States); Geisinger Medical Center, Department of Radiology, Danville, PA (United States); Agarwal, Prachi P. [University of Michigan Health System, Department of Radiology, Division of Cardiothoracic Radiology, Ann Arbor, MI (United States)

    2016-04-15

    With increasing use of pediatric cardiovascular MRI, it is important for all imagers to become familiar with the spectrum of non-cardiovascular imaging findings that can be encountered. This study aims to ascertain the prevalence and nature of these findings in pediatric cardiovascular MRIs performed at our institution. We retrospectively evaluated reports of all cardiovascular MRI studies performed at our institute from January 2008 to October 2012 in patients younger than18 years. Most studies (98%) were jointly interpreted by a pediatric cardiologist and a radiologist. We reviewed the electronic medical records of all cases with non-cardiovascular findings, defined as any imaging finding outside the cardiovascular system. Non-cardiovascular findings were classified into significant and non-significant, based on whether they were known at the time of imaging or they required additional workup or a change in management. In 849 consecutive studies (mean age 9.7 ± 6.3 years), 145 non-cardiovascular findings were found in 140 studies (16.5% of total studies). Overall, 51.0% (74/145) of non-cardiovascular findings were in the abdomen, 30.3% (44/145) were in the chest, and 18.6% (27/145) were in the spine. A total of 19 significant non-cardiovascular findings were observed in 19 studies in individual patients (2.2% of total studies, 47% male, mean age 5.9 ± 6.7 years). Significant non-cardiovascular findings included hepatic adenoma, arterially enhancing focal liver lesions, asplenia, solitary kidney, pelvicaliectasis, renal cystic diseases, gastric distention, adrenal hemorrhage, lung hypoplasia, air space disease, bronchial narrowing, pneumomediastinum and retained surgical sponge. Non-cardiovascular findings were seen in 16.5% of cardiovascular MRI studies in children, of which 2.2% were clinically significant findings. Prevalence and nature of these non-cardiovascular findings are different from those reported in adults. Attention to these findings is important

  16. Efecto agudo y retardado de siete tipos de estímulos diferentes sobre la capacidad de salto y efecto de ocho estímulos diferentes sobre la capacidad de salto y la velocidad de desplazamiento

    Directory of Open Access Journals (Sweden)

    Eduardo Sáez Sáez de Villarreal

    2008-06-01

    Full Text Available Se realizaron 3 estudios experimentales para determinar el efecto agudo y retardado de diferentes estímulos sobre la capacidad de salto (CSV y velocidad de desplazamiento (VD. En el primer estudio comprobamos el efecto de 7 tipos de estímulos de activación muscular sobre la CSV a corto y largo plazo (5 min-6 h. 12 jugadores de voleibol de 1ª división, realizaron diferentes estímulos de activación aleatoriamente. La utilización de movimientos dinámicos con cargas de alta intensidad (80-95% 1RMSP así como protocolos de calentamiento específicos para el voleibol generaron mejores efectos neuromusculares sobre las acciones explosivas realizadas a corto plazo (5 min.. Los efectos agudos positivos sobre la CSV tras una óptima activación fueron mantenidos después de largos periodos de descanso (6 horas, cuando se realizaron acciones dinámicas de alta intensidad. En el segundo estudio examinamos el efecto de tres frecuencias de entrenamiento pliométrico (1, 2 y 4 días/sem durante un programa de 7 semanas, sobre la CSV, la VD la fuerza máxima (FM y explosiva (FE. 42 estudiantes fueron aleatoriamente asignados en 4 grupos experimentales. El entrenamiento incluía saltos drop jump (DJ desde 20-40-60 cm. El tratamiento (2 días/sem, 840 saltos produjo similares mejoras en la CSV, aunque fue más eficiente (~12% y 0,014%/salto cuando se comparó con un volumen de (4 días/sem, 1.680 saltos (~18% y 0,011%/saltos. Se observaron mejoras similares en la VD en 20m y en la FM tanto utilizando un moderado o bajo como un alto volumen de entrenamiento, a pesar de que el número medio de saltos realizados por el grupo 7S (420 saltos y 14S (840 saltos fue un 25% y un 50% de los realizados por el grupo 28S (1680 saltos. En el tercer estudio examinamos el efecto retardado de 5 estímulos diferentes sobre la CSV y la VD después de 7 semanas de entrenamiento. 63 estudiantes fueron aleatoriamente asignados en 5 grupos experimentales. Se produjo una mejora

  17. Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas

    Directory of Open Access Journals (Sweden)

    Daniela Guinther Passaglia

    2013-01-01

    Full Text Available FUNDAMENTO: As consequências e os riscos do exercício físico contínuo por períodos prolongados não estão esclarecidos. OBJETIVO: Avaliar os efeitos do exercício prolongado em participantes de uma ultramaratona de 24 horas. MÉTODOS: Vinte corredores foram selecionados para avaliação, um dia antes e imediatamente após a prova em que os corredores devem percorrer a maior distância em 24 horas. Foram obtidos dados clínicos, laboratoriais e ecocardiográficos. RESULTADOS: A distância média percorrida foi de 140,3 ± 18,7 km. Os corredores apresentaram redução do peso corpóreo (p < 0,001 e da pressão arterial sistólica (p < 0,001 e diastólica (p = 0,004. As alterações hematológicas foram compatíveis com o estresse fisiológico. A concentração plasmática de creatinofosfoquinase (CPK aumentou significativamente (163,4 ± 56,8 versus 2978,4 ± 1921,9 U/L; p < 0,001 e esteve inversamente correlacionada com a distância percorrida: os que correram maiores distâncias apresentaram níveis mais baixos de CPK (Pearson r = 0,69; p = 0,02. Após a corrida, dois corredores apresentaram discreta elevação de troponina T. Em um deles, houve queda concomitante na fração de ejeção (coronariopatia foi excluída subsequentemente. O ecocardiograma na avaliação basal mostrou hipertrofia de ventrículo esquerdo em um e aumento do volume atrial esquerdo em cinco corredores. Após a prova, houve redução na relação E/A (p < 0,01. CONCLUSÃO: O exercício físico prolongado está associado a alterações cardiovasculares e metabólicas. As alterações cardiológicas encontradas sugerem que o fenômeno de fadiga cardíaca pode ocorrer nessa modalidade de corrida. O efeito a longo prazo dessas alterações, com a manutenção da prática desse tipo de atividade, ainda é desconhecido.

  18. Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia Sequestro esplênico agudo em uma mulher grávida com anemia falciforme homozigótica

    Directory of Open Access Journals (Sweden)

    Carolina Bastos Maia

    2013-04-01

    Full Text Available CONTEXT Homozygous (SS sickle-cell anemia complicated by acute splenic sequestration in adults is a rare event, and it has never been reported during pregnancy. CASE REPORT A 25-year-old woman with homozygous (SS sickle-cell disease was hospitalized at 32 weeks' of gestation presenting weakness, abdominal pain, fever and hemoglobin of 2.4 g/dl. Abnormal fetal heart rate was detected by means of cardiotocography, and 5 units of packed red cells were transfused. Cesarean was performed at 37 weeks. Both mother and baby were discharged in a good general condition. CONCLUSION This case report demonstrates the importance of immediate blood transfusion for treatment of fetal distress in cases of splenic sequestration during pregnancy. This treatment is essential for avoiding maternal and fetal complications. CONTEXTO Anemia falciforme homozigótica (SS complicada por sequestro esplênico agudo em adultos é evento raro, e nunca foi relatado durante a gravidez. RELATO DO CASO Uma mulher de 25 anos, portadora de doença falciforme homozigótica (SS, com 32 semanas de gestação, foi internada apresentando fraqueza, dor abdominal, febre e hemoglobina de 2,4 g/dl. Frequência cardíaca fetal anormal foi detectada pela cardiotocografia e a paciente recebeu 5 unidades de concentrado de hemácias. Cesariana foi realizada com 37 semanas. Mãe e filho receberam alta em bom estado geral. CONCLUSÃO Este relato de caso demonstra a importância da transfusão imediata para o tratamento de sofrimento fetal nos casos de sequestro esplênico durante a gestação. Este tratamento é imprescindível para se evitarem complicações maternas e fetais.

  19. Pseudo-aneurisma de ventrículo esquerdo por rotura cardíaca após infarto agudo do miocárdio: tratamento cirúrgico

    Directory of Open Access Journals (Sweden)

    GOMES Maurício de Castro

    1997-01-01

    Full Text Available O pseudo-aneurisma de ventrículo esquerdo após infarto agudo do miocárdio é entidade rara. Quando diagnosticado, deverá ser operado logo que possível, devido ao risco aumentado de rotura de sua parede. No período de novembro de 1992 a junho de 1995, foram encaminhados ao nosso Serviço 3 pacientes com suspeita clínica de pseudo-aneurisma de ventrículo esquerdo (VE, com sinais clínicos, radiológicos, ecocardiográficos e angiográficos característicos da lesão. O objetivo do trabalho é discutir o diagnóstico, a indicação cirúrgica, as técnicas e táticas empregadas, as complicações e os resultados cirúrgicos. Todos os pacientes foram submetidos ao ecodopplercardiograma transtorácico, que foi suficiente para o diagnóstico. Após propedêutica adequada, com realização de angiografia e ventriculografia, os pacientes foram submetidos à correção utilização de pericárdio bovino. Um dos pacientes apresentava comunicação interventricular (CIV, que foi corrigida no mesmo ato cirúrgico. Os pacientes receberam alta em bom estado geral, com controle ecocardiográfico evidenciando a correção do pseudo-aneurisma.

  20. Trastorno de estrés agudo y episodio depresivo mayor en víctimas de una inundación en Tingo María: prevalencia y efectos de su desplazamiento a un alberg

    Directory of Open Access Journals (Sweden)

    Yliana Rojas-Medina

    2008-01-01

    Full Text Available Objetivos. Determinar la prevalencia del trastorno de estrés agudo (TEA y comorbilidad con episodio depresivo mayor (TEA+EDM en víctimas de la inundación de la ciudad Tingo María-Huánuco, 20 días después del evento traumático. Materiales y métodos. Ciento veinte damnificados (personas del albergue y 110 afectados (personas en sus viviendas fueron encuestados y comparados. Se aplicó la entrevista clínica estructurada para los trastornos del Eje I del DSM-IV, versión clínica. Las prevalencias de los trastornos estudiados fueron estratificadas por edad, ser mujer, tener una pareja al tiempo de ocurrencia del desastre, estar desempleado cuando ocurrió el desastre, no hablar castellano y tener un nivel de instrucción bajo. Los datos fueron analizados en STATA v.8.0. Resultados. El 64,8% (IC95%: 58,6 -71,0 de la población estudiada fue diagnosticada con TEA y un 28,3% (IC95%: 22,4 - 34,1 tuvo TEA+EDM. Los damnificados mostraron prevalencias mayores de TEA, 80%, frente a 48,2% en los afectados (p<0,001. Para el caso de TEA+EDM las prevalencias fueron 40,0% y 15,5%, respectivamente (p<0,001. Las mujeres tienen mayor riesgo de desarrollar TEA (OR: 4,3; IC 95% 1,6-11,2 y TEA + EDM (OR: 8,7; IC 95% 1,9-40,9 independientemente de los otros factores. Conclusiones. Existe diferencias importantes entre las prevalencias de trastornos mentales de las personas que habitan en un albergue o en su vivienda; siendo mayor en quienes se ven obligados a vivir temporalmente en albergues. Las mujeres son más propensas a sufrir estos trastornos mentales.

  1. Morphoquantitative effects of acute diabetes on the myenteric neurons of the proximal colon of adult rats Efeitos morfoquantitativos do diabetes agudo sobre os neurônios mioentéricos do colo proximal de ratos adultos

    Directory of Open Access Journals (Sweden)

    Maria Montserrat D.P. Furlan

    2002-09-01

    Full Text Available The effects of acute diabetes on the density and size of the myenteric neurons of the proximal colon of adult rats were investigated. The injection of streptozotocin was followed by a period of observation of seven days, during which the diabetic animals showed weight loss, excessive food and water intake, large urinary debt and hyperglicemia. The whole-mounts from the proximal colon were stained with the techniques of Giemsa and of the NADH-diaphorase, and the employment of these techniques made it possible to verify a decrease on the neuronal density and on the cell body size of the myenteric neurons in the colon of the diabetic rats. These observations were discussed in terms of the pathophysiology of the diabetes and the experimental protocol.Foram investigados os efeitos do diabetes agudo sobre a densidade e o tamanho dos neurônios mioentéricos do colo proximal de ratos adultos. À injeção de estreptozootocina seguiu-se um período de observação de sete dias, durante os quais os animais diabéticos apresentaram perda de peso, ingestão excessiva de alimento e água, grande débito urinário e hiperglicemia. Os preparados de membrana do colo proximal foram corados pelas técnicas de Giemsa e da NADH-diaforase. A aplicação dessas técnicas permitiu constatar uma redução da densidade neuronal e do tamanho do corpo celular dos neurônios mioentéricos no colo dos ratos diabéticos. Essas observações foram discutidas em termos da patofisiologia do diabetes e do protocolo experimental.

  2. Infarto agudo del miocardio como primera manifestación del síndrome antifosfolípido primario en un paciente de veinticuatro años Acute myocardial infarction as first manifestation of primary antiphospholipid syndrome in a twenty-four years old patient

    Directory of Open Access Journals (Sweden)

    Carlos E Uribe

    2005-09-01

    Full Text Available El síndrome antifosfolípido primario usualmente se manifiesta como trombosis venosa profunda, tromboembolismo pulmonar y como evento cerebrovascular en la circulación arterial. Se presenta el caso de un paciente joven previamente sano, con infarto agudo del miocardio como primera manifestación del síndrome antifosfolípido primario.Primary antiphospholipid syndrome is usually manifested with deep venous thrombosis, pulmonary thromboembolism and arterial thrombosis, including cerebrovascular accidents. We report the case of a previously healthy young patient who suffered an acute myocardial infarction as the first manifestation of a primary antiphospholipid syndrome.

  3. Efecto de la Exposición a un Protocolo de Estrés Social Agudo sobre los Niveles Sistémicos de Cortisol y la Ejecución de una Tarea de Atención Sostenida y Dividida

    OpenAIRE

    OLGA TARAZONA; JEIMMY CERÓN; MARISOL LAMPREA

    2013-01-01

    La presente investigación tuvo como objetivo determinar los efectos del estrés social agudo inducido experimentalmente con una versión modificada del TSST (Trier Social Stress Test), en los niveles sistémicos de la hormona cortisol y en la ejecución de una tarea de atención sostenida y dividida, en estudiantes universitarios de ambos sexos. Los resultados mostraron que el protocolo modificado del TSST produjo incrementos en los niveles sistémicos de cortisol en los participantes de sexo mascu...

  4. Cocoa, blood pressure, and cardiovascular health.

    Science.gov (United States)

    Ferri, Claudio; Desideri, Giovambattista; Ferri, Livia; Proietti, Ilenia; Di Agostino, Stefania; Martella, Letizia; Mai, Francesca; Di Giosia, Paolo; Grassi, Davide

    2015-11-18

    High blood pressure is an important risk factor for cardiovascular disease and cardiovascular events worldwide. Clinical and epidemiological studies suggest that cocoa-rich products reduce the risk of cardiovascular disease. According to this, cocoa has a high content in polyphenols, especially flavanols. Flavanols have been described to exert favorable effects on endothelium-derived vasodilation via the stimulation of nitric oxide-synthase, the increased availability of l-arginine, and the decreased degradation of NO. Cocoa may also have a beneficial effect by protecting against oxidative stress alterations and via decreased platelet aggregation, decreased lipid oxidation, and insulin resistance. These effects are associated with a decrease of blood pressure and a favorable trend toward a reduction in cardiovascular events and strokes. Previous meta-analyses have shown that cocoa-rich foods may reduce blood pressure. Long-term trials investigating the effect of cocoa products are needed to determine whether or not blood pressure is reduced on a chronic basis by daily ingestion of cocoa. Furthermore, long-term trials investigating the effect of cocoa on clinical outcomes are also needed to assess whether cocoa has an effect on cardiovascular events. A 3 mmHg systolic blood pressure reduction has been estimated to decrease the risk of cardiovascular and all-cause mortality. This paper summarizes new findings concerning cocoa effects on blood pressure and cardiovascular health, focusing on putative mechanisms of action and "nutraceutical " viewpoints.

  5. Effect of ionizing radiation on cardiovascular system

    International Nuclear Information System (INIS)

    Milliat, F.; Benderitter, M.; Gaugler, M.H.

    2011-01-01

    Radiotherapy treatment for cancer of the chest, mediastinal area or the neck area is associated with increased risk of cardiovascular disease. With the increasing number of cancer patients and the increased treatment efficiency, the number of cancer survivors is increasing exponentially. The cancer survivors live longer and their long-term follow-up must be considered. The cardiovascular toxicity is mainly associated with the treatment of breast cancer, Hodgkin's lymphoma and head and neck cancer. Radiation-induced cardiovascular effects are insidious and chronic. Their occurrence is linked to numerous factors including the age of the patient at the beginning of the radiotherapy schedule, the number of years following radiotherapy, the doses (and volume) to the heart and the large vessels (coronary and carotid arteries), and the association with the traditional cardiovascular risk factors. Pathophysiological mechanisms remain unclear and, even if similarities with age-related atherosclerosis were established, the specificities of the radiation-induced atherosclerosis for high doses remain to be discovered. For low/moderate doses of ionising radiation, recent epidemiological studies provide evidence of increased risk of cardiovascular pathologies. A better knowledge of the mechanisms associated with the radiation-induced cardiovascular pathologies and the more precise identification of the populations at risk in the future should allow a more effective care of these patients with cardiovascular risk. (authors)

  6. [Cooperative Cardiovascular Disease Research Network (RECAVA)].

    Science.gov (United States)

    García-Dorado, David; Castro-Beiras, Alfonso; Díez, Javier; Gabriel, Rafael; Gimeno-Blanes, Juan R; Ortiz de Landázuri, Manuel; Sánchez, Pedro L; Fernández-Avilés, Francisco

    2008-01-01

    Today, cardiovascular disease is the principal cause of death and hospitalization in Spain, and accounts for an annual healthcare budget of more than 4000 million euros. Consequently, early diagnosis, effective prevention, and the optimum treatment of cardiovascular disease present a significant social and healthcare challenge for the country. In this context, combining all available resources to increase the efficacy and healthcare benefits of scientific research is a priority. This rationale prompted the establishment of the Spanish Cooperative Cardiovascular Disease Research Network, or RECAVA (Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares), 5 years ago. Since its foundation, RECAVA's activities have focused on achieving four objectives: a) to facilitate contacts between basic, clinical and epidemiological researchers; b) to promote the shared use of advanced technological facilities; c) to apply research results to clinical practice, and d) to train a new generation of translational cardiovascular researchers in Spain. At present, RECAVA consists of 41 research groups and seven shared technological facilities. RECAVA's research strategy is based on a scientific design matrix centered on the most important cardiovascular processes. The level of RECAVA's research activity is reflected in the fact that 28 co-authored articles were published in international journals during the first six months of 2007, with each involving contributions from at least two groups in the network. Finally, RECAVA also participates in the work of the Spanish National Center for Cardiovascular Research, or CNIC (Centro Nacional de Investigación Cardiovascular), and some established Biomedical Research Network Centers, or CIBER (Centros de Investigación Biomédica en RED), with the aim of consolidating the development of a dynamic multidisciplinary research framework that is capable of meeting the growing challenge that cardiovascular disease will present

  7. Cardiovascular regulation during water immersion.

    Science.gov (United States)

    Park, K S; Choi, J K; Park, Y S

    1999-11-01

    Head-out water immersion at thermoneutral temperature (34-35 degrees C) increases cardiac output for a given O2 consumption, leading to a relative hyperperfusion of peripheral tissues. To determine if subjects immersed in water at a colder temperature show similar responses and to explore the significance of the hyperperfusion, cardiovascular functions were investigated (impedance cardiography) on 10 men at rest and while performing exercise on a leg cycle ergometer (delta M = approximately 95 W.m-2) in air and in water at 34.5 degrees C and 30 degrees C, respectively. In subjects resting in water, the cardiac output increased by approximately 50% compared to that in air, mainly due to a rise in stroke volume. The stroke volume change tended to be greater in 30 degrees C water than in 34.5 degrees C water, and this was due to a greater increase in cardiac preload, as indicated by a significantly greater left ventricular end-diastolic volume. Arterial systolic pressure rose slightly during water immersion. Arterial diastolic pressure remained unchanged in 34.5 degrees C water, but it rose in 30 degrees C water. The total peripheral resistance fell 37% in 34.5 degrees C water and 32% in 30 degrees C water. Both in air and in water, mild exercise increased the cardiac output, and this was mainly due to an increase in heart rate. Since, however, the stroke volume increased with water immersion, cardiac output at a given work load appeared to be significantly higher in water than in air. The arterial pressures did not decrease with water immersion, despite a marked reduction in total peripheral resistance. These results suggest that 1) during cold water immersion, peripheral vasoconstriction provides an additional increase in cardiac preload, leading to a further increase in the stroke volume compared to that of the thermoneutral water immersion, 2) the mechanism of cardiovascular adjustment during dynamic exercise is not changed by the persistent increase in cardiac

  8. Contribuição do cuidado clínico de enfermagem para o conforto psicoespiritual de mulheres com infarto agudo do miocárdio Contribución del cuidado clínico de enfermería para el confort psicoespiritual de mujeres con infarto agudo de miocardio Contribution of nursing clinical care for psycho-spiritual comfort of women with acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Keila Maria de Azevedo Ponte

    2012-12-01

    Full Text Available Objetivou-se analisar a contribuição do cuidado clínico de enfermagem para o conforto psicoespiritual de mulheres com Infarto Agudo do Miocárdio (IAM, mediado pela pesquisa-cuidado com base na Teoria do Conforto. Os sujeitos foram nove mulheres admitidas com IAM no período de abril a junho de 2011 em um hospital de Cardiologia em Sobral - Ceará, Brasil. O primeiro encontro ocorreu na admissão e durou em média seis horas; depois ocorreram mais três encontros. Para coleta e análise das informações, foram empregados entrevista individual semiestruturada, diário de campo, observação participante e análise temática categorial de conteúdo. Os cuidados implementados no contexto psicoespiritual foram: fortalecer a espiritualidade, esclarecer sobre o adoecimento, ajudar no enfrentamento da nova condição de saúde e nas situações de confusão mental e desorientação. A percepção do conforto psicoespiritual ocorreu por meio da implementação de cuidados clínicos neste contexto, utilizando-se pesquisa-cuidado com base na Teoria do Conforto.El objetivo del estudio fue analizar la contribución de la atención clínica de enfermería para el confort psicoespiritual de mujeres con Infarto Agudo del Miocardio (IAM, mediada por la investigación-atención basada en la Teoría del Confort. Participaron nueve mujeres que ingresaron con IAM entre abril y junio de 2011 en el hospital de Cardiología de Sobral, Ceará, Brasil. El primer encuentro ocurrió en la admisión y duró alrededor de seis horas, después ocurrieron más tres encuentros. Para recolección y análisis de las informaciones, se utilizaron entrevista semi-estructurada, diarios de campo, observación participante y análisis temático categorial de contenido. Las atenciones psicoespirituales fueron: fortalecer la espiritualidad, aclarar las dudas sobre la enfermedad, ayudar a enfrentarse el nuevo estado de salud y las situaciones de confusión mental y desorientación. La

  9. Cardiovascular magnetic resonance in congenital heart disease

    International Nuclear Information System (INIS)

    Cazacu, A.; Ciubotaru, A.

    2010-01-01

    The increasing prevalence of congenital heart disease can be attributed to major improvements in diagnosis and treatment. Cardiovascular magnetic resonance imaging plays an important role in the clinical management strategy of patients with congenital heart disease. The development of new cardiovascular magnetic resonance (CMR) techniques allows comprehensive assessment of complex cardiac anatomy and function and provides information about the long-term residual post-operative lesions and complications of surgery. It overcomes many of the limitations of echocardiography and cardiac catheterization. This review evaluates the role of cardiovascular magnetic resonance imaging modality in the management of subject with congenital heart disease (CHD). (authors)

  10. Thyroid disease and the cardiovascular system.

    Science.gov (United States)

    Danzi, Sara; Klein, Irwin

    2014-06-01

    Thyroid hormones, specifically triiodothyronine (T3), have significant effects on the heart and cardiovascular system. Hypothyroidism, hyperthyroidism, subclinical thyroid disease, and low T3 syndrome each cause cardiac and cardiovascular abnormalities through both genomic and nongenomic effects on cardiac myocytes and vascular smooth muscle cells. In compromised health, such as occurs in heart disease, alterations in thyroid hormone metabolism may further impair cardiac and cardiovascular function. Diagnosis and treatment of cardiac disease may benefit from including analysis of thyroid hormone status, including serum total T3 levels. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Subclinical organ damage and cardiovascular risk prediction

    DEFF Research Database (Denmark)

    Sehestedt, Thomas; Olsen, Michael H

    2010-01-01

    Traditional cardiovascular risk factors have poor prognostic value for individuals and screening for subclinical organ damage has been recommended in hypertension in recent guidelines. The aim of this review was to investigate the clinical impact of the additive prognostic information provided...... by measuring subclinical organ damage. We have (i) reviewed recent studies linking markers of subclinical organ damage in the heart, blood vessels and kidney to cardiovascular risk; (ii) discussed the evidence for improvement in cardiovascular risk prediction using markers of subclinical organ damage; (iii...

  12. Magnetic resonance imaging of the cardiovascular system

    International Nuclear Information System (INIS)

    Masuda, Yoshiaki; Imai, Hiroshi; Watanabe, Sigeru; Inagaki, Yoshiaki; Tateno, Yukio; Ikehira, Hiroo.

    1990-01-01

    Magnetic resonance imaging (MRI) is a new noninvasive technique for visualization of the cardiovascular system, and is used to evaluate tissue characteristics, cardiac function and blood flow abnormalities, as well as to obtain morphological information. In this paper we presented results of clinical and laboratory research obtained using conventional spin echo MRI with regard to cardiovascular anatomy, tissue characterization and physiology. Furthermore, experience with two new techniques, cine-MRI and volume-selected MR spectroscopy, and their potential clinical usefulness in detecting cardiovascular diseases are documented. (author)

  13. Residual generator for cardiovascular anomalies detection

    KAUST Repository

    Belkhatir, Zehor

    2014-06-01

    This paper discusses the possibility of using observer-based approaches for cardiovascular anomalies detection and isolation. We consider a lumped parameter model of the cardiovascular system that can be written in a form of nonlinear state-space representation. We show that residuals that are sensitive to variations in some cardiovascular parameters and to abnormal opening and closure of the valves, can be generated. Since the whole state is not easily available for measurement, we propose to associate the residual generator to a robust extended kalman filter. Numerical results performed on synthetic data are provided.

  14. Evolución de la mortalidad por enfermedad isquémica del corazón e infarto agudo del miocardio en Costa Rica, 1970-2001 Trends in mortality from ischemic heart disease and acute myocardial infarction in Costa Rica, 1970-2001

    Directory of Open Access Journals (Sweden)

    Marlene Roselló Araya

    2004-11-01

    Full Text Available OBJETIVO: Describir la evolución epidemiológica de la mortalidad por enfermedades cardiovasculares (ECV, enfermedad isquémica del corazón (EIC e infarto agudo del miocardio (IAM en Costa Rica, según el sexo y la región geográfica, entre los años 1970 y 2001. MÉTODOS: Se realizó un estudio descriptivo de la mortalidad por ECV, EIC e IAM en Costa Rica entre 1970 y 2001. La información se obtuvo de la base de datos del Centro Centroamericano de Población. Los datos de mortalidad por EIC e IAM entre 1970 y 2001 se analizaron según la revisión mas actualizada de la Clasificación Internacional de Enfermedades (CIE. El territorio costarricense se dividió en: región metropolitana (8 cantones, región semiurbana Valle Central (18 cantones, región rural Valle Central (17 cantones, región semiurbana bajura (12 cantones y región rural bajura (26 cantones. La tendencia de la mortalidad se analizó por quinquenios (entre 1970 y 1999 y el bienio de 2000 - 2001 mediante las tasas brutas de mortalidad por 100 000 habitantes para cada causa o grupo de causas, según la edad, el sexo y el año de fallecimiento. Las tasas se ajustaron por edad, sexo, año de fallecimiento y región geográfica mediante el método directo, usando como población estándar la de América Latina en 1960. RESULTADOS: La mortalidad por ECV disminuyó 33% en promedio (46,6% en mujeres y 20,2% en hombres, mientras que la mortalidad por EIC aumentó un promedio de 18,4% (6,1% mujeres y 28,4% hombres. La tasa ajustada de mortalidad por IAM en hombres aumentó 12,8% en el período de estudio, con un ligero descenso de 4,4% en mujeres. La mortalidad por ECV, EIC e IAM fue mayor en hombres que en mujeres durante todo el período de estudio. Las tasas de mortalidad por EIC e IAM se elevaron en las regiones semiurbanas y rurales, especialmente en la región rural bajura, donde aumentaron con respecto al quinquenio de 1995 - 1999 en 123,9% y 76,9%, respectivamente

  15. Robotics in percutaneous cardiovascular interventions.

    Science.gov (United States)

    Pourdjabbar, Ali; Ang, Lawrence; Behnamfar, Omid; Patel, Mitul P; Reeves, Ryan R; Campbell, Paul T; Madder, Ryan D; Mahmud, Ehtisham

    2017-11-01

    The fundamental technique of performing percutaneous cardiovascular (CV) interventions has remained unchanged and requires operators to wear heavy lead aprons to minimize exposure to ionizing radiation. Robotic technology is now being utilized in interventional cardiology partially as a direct result of the increasing appreciation of the long-term occupational hazards of the field. This review was undertaken to report the clinical outcomes of percutaneous robotic coronary and peripheral vascular interventions. Areas covered: A systematic literature review of percutaneous robotic CV interventions was undertaken. The safety and feasibility of percutaneous robotically-assisted CV interventions has been validated in simple to complex coronary disease, and iliofemoral disease. Studies have shown that robotically-assisted PCI significantly reduces operator exposure to harmful ionizing radiation without compromising procedural success or clinical efficacy. In addition to the operator benefits, robotically-assisted intervention has the potential for patient advantages by allowing more accurate lesion length measurement, precise stent placement and lower patient radiation exposure. However, further investigation is required to fully elucidate these potential benefits. Expert commentary: Incremental improvement in robotic technology and telecommunications would enable treatment of an even broader patient population, and potentially provide remote robotic PCI.

  16. Metabolic syndrome and cardiovascular risk

    Directory of Open Access Journals (Sweden)

    Abdullah M Alshehri

    2010-01-01

    Full Text Available The constellation of dyslipidemia (hypertriglyceridemia and low levels of high-density lipoprotein cholesterol, elevated blood pressure, impaired glucose tolerance, and central obesity is now classified as metabolic syndrome, also called syndrome X. In the past few years, several expert groups have attempted to set forth simple diagnostic criteria for use in clinical practice to identify patients who manifest the multiple components of the metabolic syndrome. These criteria have varied somewhat in specific elements, but in general, they include a combination of multiple and metabolic risk factors. The most widely recognized of the metabolic risk factors are atherogenic dyslipidemia, elevated blood pressure, and elevated plasma glucose. Individuals with these characteristics, commonly manifest a prothrombotic state as well as and a proinflammatory state. Atherogenic dyslipidemia consists of an aggregation of lipoprotein abnormalities including elevated serum triglyceride and apolipoprotein B (apoB, increased small LDL particles, and a reduced level of HDL cholesterol (HDL-C. The metabolic syndrome is often referred to as if it were a discrete entity with a single cause. Available data suggest that it truly is a syndrome, ie, a grouping of atherosclerotic cardiovascular disease (ASCVD risk factors, that probably has more than one cause. Regardless of cause, the syndrome identifies individuals at an elevated risk for ASCVD. The magnitude of the increased risk can vary according to the components of the syndrome present as well as the other, non-metabolic syndrome risk factors in a particular person.

  17. Pomegranate for Your Cardiovascular Health

    Directory of Open Access Journals (Sweden)

    Michael Aviram

    2013-04-01

    Full Text Available Pomegranate is a source of some very potent antioxidants (tannins, anthocyanins which are considered to be also potent anti-atherogenic agents. The combination of the above unique various types of pomegranate polyphenols provides a much wider spectrum of action against several types of free radicals. Indeed, pomegranate is superior in comparison to other antioxidants in protecting low-density lipoprotein (LDL, “the bad cholesterol” and high-density lipoprotein (HDL, “the good cholesterol” from oxidation, and as a result it attenuates atherosclerosis development and its consequent cardiovascular events. Pomegranate antioxidants are not free, but are attached to the pomegranate sugars, and hence were shown to be beneficial even in diabetic patients. Furthermore, pomegranate antioxidants are unique in their ability to increase the activity of the HDL-associated paraoxonase 1 (PON1, which breaks down harmful oxidized lipids in lipoproteins, in macrophages, and in atherosclerotic plaques. Finally, unique pomegranate antioxidants beneficially decrease blood pressure. All the above beneficial characteristics make the pomegranate a uniquely healthy fruit.

  18. Cardiovascular molecular imaging of apoptosis

    International Nuclear Information System (INIS)

    Wolters, S.L.; Reutelingsperger, C.P.M.; Corsten, M.F.; Hofstra, L.; Narula, J.

    2007-01-01

    Molecular imaging strives to visualise processes at the molecular and cellular level in vivo. Understanding these processes supports diagnosis and evaluation of therapeutic efficacy on an individual basis and thereby makes personalised medicine possible. Apoptosis is a well-organised mode of cell suicide that plays a role in cardiovascular diseases (CVD). Apoptosis is associated with loss of cardiomyocytes following myocardial infarction, atherosclerotic plaque instability, congestive heart failure and allograft rejection of the transplanted heart. Thus, apoptosis constitutes an attractive target for molecular imaging of CVD. Our current knowledge about the molecular players and mechanisms underlying apoptosis offers a rich palette of potential molecular targets for molecular imaging. However, only a few have been successfully developed so far. This review highlights aspects of the molecular machinery and biochemistry of apoptosis relevant to the development of molecular imaging probes. It surveys the role of apoptosis in four major areas of CVD and portrays the importance and future perspectives of apoptosis imaging. The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical and clinical studies. (orig.)

  19. Molecular imaging in cardiovascular diseases

    International Nuclear Information System (INIS)

    Botnar, R.M.; Ebersberger, H.; Noerenberg, D.

    2015-01-01

    Cardiovascular diseases remain the leading cause of morbidity and mortality in industrialized and developing countries. In clinical practice, the in-vivo identification of atherosclerotic lesions, which can lead to complications such as heart attack or stroke, remains difficult. Imaging techniques provide the reference standard for the detection of clinically significant atherosclerotic changes in the coronary and carotid arteries. The assessment of the luminal narrowing is feasible, while the differentiation of stable and potentially unstable or vulnerable atherosclerotic plaques is currently not possible using non-invasive imaging. With high spatial resolution and high soft tissue contrast, magnetic resonance imaging (MRI) is a suitable method for the evaluation of the thin arterial wall. In clinical practice, native MRI of the vessel wall already allows the differentiation and characterization of components of atherosclerotic plaques in the carotid arteries and the aorta. Additional diagnostic information can be gained by the use of non-specific MRI contrast agents. With the development of targeted molecular probes, that highlight specific molecules or cells, pathological processes can be visualized at a molecular level with high spatial resolution. In this review article, the development of pathophysiological changes leading to the development of the arterial wall are introduced and discussed. Additionally, principles of contrast enhanced imaging with non-specific contrast agents and molecular probes will be discussed and latest developments in the field of molecular imaging of the vascular wall will be introduced.

  20. Reengineering a cardiovascular surgery service.

    Science.gov (United States)

    Tunick, P A; Etkin, S; Horrocks, A; Jeglinski, G; Kelly, J; Sutton, P

    1997-04-01

    Reengineering, involving the radical redesign of business processes, has been used successfully in a variety of health care settings. In 1994 New York University (NYU) Medical Center (MC) launched its first reengineering team, whose purpose was to redesign the entire process of caring for patients-from referral to discharge-on the cardiovascular (CV) surgery service. REENIGINEERING TEAM: The multidisciplinary CV Surgery Reengineering Team was charged with two goals: improving customer (patient, family, and referring physician) satisfaction and improving profitability. The methodology to be used was based on a reengineering philosophy-discarding basic assumptions and designing the patient care process from the ground up. THE TRANSFER-IN INITIATIVE: A survey of NYU cardiologists, distributed in April 1994, suggested that the organization was considered a difficult place to transfer patients. The team's recommendations led to a new, streamlined transfer-in policy. The average waiting time from when a referring physician requested a patient transfer and the time when an NYUMC physician accepted the transfer decreased from an average of 9 hours under the old system to immediate acceptance. Three customer satisfaction task forces implemented multiple programs to make the service more user friendly. In addition, referrals increased and length of stay decreased, without an adverse impact on the mortality rate. For the first time at NYUMC, a multidisciplinary team was given the mandate to achieve major changes in an entire patient care process. Similar projects are now underway.

  1. Cardiovascular whole-body MRI

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, Harald [Department of Clinical Radiology, University Hospitals Munich - Grosshadern Campus, Ludwig Maxmilians University Munich, Marchioninistr. 15, 81377 Munich (Germany)], E-mail: harald.kramer@med.uni-muenchen.de; Nikolaou, Konstantin; Reiser, Maximilian F. [Department of Clinical Radiology, University Hospitals Munich - Grosshadern Campus, Ludwig Maxmilians University Munich, Marchioninistr. 15, 81377 Munich (Germany)

    2009-06-15

    Cardiovascular diseases still rank number one in mortality statistics in the industrialized world. In these countries the five most common causes of death are associated to atherosclerotic changes of the arterial vasculature. Due to its often long lasting treatment and the possible loss of ability to work atherosclerotic disease constitutes an economic factor which should not be disregarded. Thus screening for atherosclerotic disease seems to be reasonable because as known the potential to influence atherosclerotic changes is higher in an early stage of the disease. Not in every case it is possible to cure the disease but sometimes progression can be controlled and decelerated. Imaging of the arterial vasculature was limited to invasive procedures associated with ionizing radiation for a long time. Non-invasive exams like the 'ankle-brachial-index' (ABI) can indicate the presence of PAOD, an exact localization of the pathologic changes is only possible with imaging methods. For cardiac imaging likewise the only non-invasive exams have been ECG and auscultation. Certainly echocardiography is an excellent technique to access cardiac function but it depends very much on both, the examining physician and the patient. MRI constitutes a non-invasive imaging modality without ionizing radiation offering excellent reproducible image quality.

  2. Cardiovascular whole-body MRI

    International Nuclear Information System (INIS)

    Kramer, Harald; Nikolaou, Konstantin; Reiser, Maximilian F.

    2009-01-01

    Cardiovascular diseases still rank number one in mortality statistics in the industrialized world. In these countries the five most common causes of death are associated to atherosclerotic changes of the arterial vasculature. Due to its often long lasting treatment and the possible loss of ability to work atherosclerotic disease constitutes an economic factor which should not be disregarded. Thus screening for atherosclerotic disease seems to be reasonable because as known the potential to influence atherosclerotic changes is higher in an early stage of the disease. Not in every case it is possible to cure the disease but sometimes progression can be controlled and decelerated. Imaging of the arterial vasculature was limited to invasive procedures associated with ionizing radiation for a long time. Non-invasive exams like the 'ankle-brachial-index' (ABI) can indicate the presence of PAOD, an exact localization of the pathologic changes is only possible with imaging methods. For cardiac imaging likewise the only non-invasive exams have been ECG and auscultation. Certainly echocardiography is an excellent technique to access cardiac function but it depends very much on both, the examining physician and the patient. MRI constitutes a non-invasive imaging modality without ionizing radiation offering excellent reproducible image quality.

  3. Globalization, Work, and Cardiovascular Disease.

    Science.gov (United States)

    Schnall, Peter L; Dobson, Marnie; Landsbergis, Paul

    2016-10-01

    Cardiovascular disease (CVD), a global epidemic, is responsible for about 30% of all deaths worldwide. While mortality rates from CVD have been mostly declining in the advanced industrialized nations, CVD risk factors, including hypertension, obesity, and diabetes, have been on the increase everywhere. Researchers investigating the social causes of CVD have produced a robust body of evidence documenting the relationships between the work environment and CVD, including through the mechanisms of psychosocial work stressors. We review the empirical evidence linking work, psychosocial stressors, and CVD. These work stressors can produce chronic biologic arousal and promote unhealthy behaviors and thus, increased CVD risk. We offer a theoretical model that illustrates how economic globalization influences the labor market and work organization in high-income countries, which, in turn, exacerbates job characteristics, such as demands, low job control, effort-reward imbalance, job insecurity, and long work hours. There is also a growing interest in "upstream" factors among work stress researchers, including precarious employment, downsizing/restructuring, privatization, and lean production. We conclude with suggestions for future epidemiologic research on the role of work in the development of CVD, as well as policy recommendations for prevention of work-related CVD. © The Author(s) 2016.

  4. Pediatric and neonatal cardiovascular pharmacology.

    Science.gov (United States)

    Miller-Hoover, Suzan R

    2003-01-01

    Advances in cardiology, surgical techniques, postoperative care, and medications have improved the chances of long-term survival of the neonatal and pediatric patient with complex congenital cardiac anomalies. Rather than undergoing palliative repair, these children are now frequently taken to the operating room for complete repair. As complete repair becomes the norm, collaborative management and a thorough understanding of the pre and postoperative medications used become essential to the care of these patients. The nurse's ability to understand preop, postop, and management medications is enhanced by an understanding of the principles of cardiac anatomy and physiology, as well as developmental changes in cardiac function. All of these are reviewed. In addition, since the safe and effective administration of these drugs depends on the pediatric intensive care unit (PICU) and neonatal intensive care unit (NICU) nurse's thorough knowledge of these medications and their effects on the cardiovascular system, a brief review of these medications is presented. While new technology and techniques are improving survival rates for children with congenital heart anomalies, it is the postoperative care that these children receive that enhances the patient's survival even more.

  5. Matriarchal model for cardiovascular prevention.

    Science.gov (United States)

    Wild, R A; Taylor, E L; Knehans, A; Cleaver, V

    1994-02-01

    Family patterns of cardiovascular risk behavior are well documented. Significant correlation exists between spouse-spouse, parent-child, and sibling-sibling for cholesterol, high- and low-density lipoprotein, diet, physical activity, and smoking. Family/environmental influences are important in how/if risk and/or preventive behavior is learned. The family matriarch commonly functions as gatekeeper, controlling eating behavior, access to health care, and other patterns. She often acts as menu planner, shopper, and preparer of meals for all family members. She provides information and verbal reinforcement about food and is a powerful model concerning dietary practices. In fact, the mother, as head of household in most single-parent families, may be the only adult model for many children. Because relevance and credibility are the most important characteristics of a behavioral model, parents (especially mothers) are strong models for observational learning by children. Risk factor information and risk reduction activities adopted by the matriarch can be generalized to the entire family if she learns the skills to act as a change agent. Initiation of this process of education and training the matriarch lies with primary care providers for women (Ob-Gyns see most women). By teaching risk reduction to the matriarch as a component of primary care, physician interaction can have a rippling effect.

  6. Metabolic syndrome and cardiovascular risk

    Directory of Open Access Journals (Sweden)

    Abdullah M Alshehri

    2010-11-01

    Full Text Available The constellation of dyslipidemia (hypertriglyceridemia and low levels of high-density lipoprotein cholesterol, elevated blood pressure, impaired glucose tolerance, and central obesity is now classified as metabolic syndrome, also called syndrome X. In the past few years, several expert groups have attempted to set forth simple diagnostic criteria for use in clinical practice to identify patients who manifest the multiple components of the metabolic syndrome. These criteria have varied somewhat in specific elements, but in general, they include a combination of multiple and metabolic risk factors. The most widely recognized of the metabolic risk factors are atherogenic dyslipidemia, elevated blood pressure, and elevated plasma glucose. Individuals with these characteristics, commonly manifest a prothrombotic state as well as and a proinflammatory state. Atherogenic dyslipidemia consists of an aggregation of lipoprotein abnormalities including elevated serum triglyceride and apolipoprotein B (apoB, increased small LDL particles, and a reduced level of HDL cholesterol (HDL-C. The metabolic syndrome is often referred to as if it were a discrete entity with a single cause. Available data suggest that it truly is a syndrome, ie, a grouping of atherosclerotic cardiovascular disease (ASCVD risk factors, that probably has more than one cause. Regardless of cause, the syndrome identifies individuals at an elevated risk for ASCVD. The magnitude of the increased risk can vary according to the components of the syndrome present as well as the other, non-metabolic syndrome risk factors in a particular person.

  7. Cardiovascular drugs and erectile dysfunction

    Directory of Open Access Journals (Sweden)

    Terzić Branka M.

    2014-01-01

    Full Text Available Erectile dysfunction (ED is a disorder, which basically can have organic nature, psychological or mixed. ED is not a rarity, and data on its prevalence vary, depending on the areas in which the survey was conducted, followed by a period of research and the definition of the disorder. Most of the men associate ED problem with using drugs, especially cardiac. Even though there is some truth in it, mainly the real causes of ED are not well known even to professionals. Contemporary studies of risk factors for cardiovascular disease, particularly coronary heart disease, have shown the clear link between erectile dysfunction and coronary heart disease, wherein ED first manifests. While, ED precedes the onset of symptoms of coronary heart disease and show to the patient and the physician a clear signal of the direction for conducting diagnostic tests and further treatment in the interest of the health of patients. Endocrine, and neurological disorders, as well as bad habits in addition to the cardiac and kidney disease, lead to ED. It is known also, that the use of cardiac medicines may contribute to ED occurrence. Better knowledge of adverse reactions to medicines, a better understanding of the nature of the disease and the implementation of necessary diagnostic procedures, with a good choice of medication, contribute to solving problems related to ED. If all mentioned do not help, there is the possibility of using new drugs to correct ED.

  8. Cardiovascular molecular imaging of apoptosis

    Energy Technology Data Exchange (ETDEWEB)

    Wolters, S.L.; Reutelingsperger, C.P.M. [Maastricht University, Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht (Netherlands); Corsten, M.F.; Hofstra, L. [Maastricht University, Department of Cardiology, Cardiovascular Research Institute Maastricht, P.O. Box 616, Maastricht (Netherlands); Narula, J. [University of California Irvine, Department of Cardiology, Irvine (United States)

    2007-06-15

    Molecular imaging strives to visualise processes at the molecular and cellular level in vivo. Understanding these processes supports diagnosis and evaluation of therapeutic efficacy on an individual basis and thereby makes personalised medicine possible. Apoptosis is a well-organised mode of cell suicide that plays a role in cardiovascular diseases (CVD). Apoptosis is associated with loss of cardiomyocytes following myocardial infarction, atherosclerotic plaque instability, congestive heart failure and allograft rejection of the transplanted heart. Thus, apoptosis constitutes an attractive target for molecular imaging of CVD. Our current knowledge about the molecular players and mechanisms underlying apoptosis offers a rich palette of potential molecular targets for molecular imaging. However, only a few have been successfully developed so far. This review highlights aspects of the molecular machinery and biochemistry of apoptosis relevant to the development of molecular imaging probes. It surveys the role of apoptosis in four major areas of CVD and portrays the importance and future perspectives of apoptosis imaging. The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical and clinical studies. (orig.)

  9. Cardiovascular Diseases in HIV-infected Subjects (HIV-HEART Study)

    Science.gov (United States)

    2010-05-07

    Detection of Frequency, Severity and Progression of Cardiovascular Diseases in Patients With HIV-infection.; Effect on Cardiovascular Risk and Life Quality by Age, Gender, Classic Cardiovascular Risk Factors,; HIV-specific Cardiovascular Risk Factors, Cardiovascular Medication, Antiretroviral Medication

  10. Coffee intake, cardiovascular disease and allcause mortality

    DEFF Research Database (Denmark)

    Nordestgaard, Ask Tybjærg; Nordestgaard, Børge Grønne

    2016-01-01

    Background: Coffee has been associated with modestly lower risk of cardiovascular disease and all-cause mortality in meta-analyses; however, it is unclear whether these are causal associations. We tested first whether coffee intake is associated with cardiovascular disease and all-cause mortality...... observationally; second, whether genetic variations previously associated with caffeine intake are associated with coffee intake; and third, whether the genetic variations are associated with cardiovascular disease and all-cause mortality. Methods: First, we used multivariable adjusted Cox proportional hazard......- and age adjusted Cox proportional hazard regression models to examine genetic associations with cardiovascular disease and all-cause mortality in 112 509 Danes. Finally, we used sex and age-adjusted logistic regression models to examine genetic associations with ischaemic heart disease including...

  11. Influenza vaccines for preventing cardiovascular disease

    Directory of Open Access Journals (Sweden)

    Christine Clar

    Full Text Available ABSTRACTBACKGROUND: This is an update of the original review published in 2008. The risk of adverse cardiovascular outcomes is increased with influenza-like infection, and vaccination against influenza may improve cardiovascular outcomes.OBJECTIVES: To assess the potential benefits of influenza vaccination for primary and secondary prevention of cardiovascular disease.METHODS:Search methods:We searched the following electronic databases on 18 October 2013: The Cochrane Library (including Cochrane Central Register of Controlled Trials (CENTRAL, Database of Abstracts of Reviews of Effects (DARE, Economic Evaluation Database (EED and Health Technology Assessment database (HTA, MEDLINE, EMBASE, Science Citation Index Expanded, Conference Proceedings Citation Index - Science and ongoing trials registers (www.controlled-trials.com/ and www.clinicaltrials.gov. We examined reference lists of relevant primary studies and systematic reviews. We performed a limited PubMed search on 20 February 2015, just before publication.Selection criteria:Randomised controlled trials (RCTs of influenza vaccination compared with placebo or no treatment in participants with or without cardiovascular disease, assessing cardiovascular death or non-fatal cardiovascular events.Data collection and analysis:We used standard methodological procedures as expected by The Cochrane Collaboration. We carried out meta-analyses only for cardiovascular death, as other outcomes were reported too infrequently. We expressed effect sizes as risk ratios (RRs, and we used random-effects models.MAIN RESULTS: We included eight trials of influenza vaccination compared with placebo or no vaccination, with 12,029 participants receiving at least one vaccination or control treatment. We included six new studies (n = 11,251, in addition to the two included in the previous version of the review. Four of these trials (n = 10,347 focused on prevention of influenza in the general or elderly population

  12. Influenza vaccines for preventing cardiovascular disease.

    Science.gov (United States)

    Clar, Christine; Oseni, Zainab; Flowers, Nadine; Keshtkar-Jahromi, Maryam; Rees, Karen

    2015-05-05

    This is an update of the original review published in 2008. The risk of adverse cardiovascular outcomes is increased with influenza-like infection, and vaccination against influenza may improve cardiovascular outcomes. To assess the potential benefits of influenza vaccination for primary and secondary prevention of cardiovascular disease. We searched the following electronic databases on 18 October 2013: The Cochrane Library (including Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effects (DARE), Economic Evaluation Database (EED) and Health Technology Assessment database (HTA)), MEDLINE, EMBASE, Science Citation Index Expanded, Conference Proceedings Citation Index - Science and ongoing trials registers (www.controlled-trials.com/ and www.clinicaltrials.gov). We examined reference lists of relevant primary studies and systematic reviews. We performed a limited PubMed search on 20 February 2015, just before publication. Randomised controlled trials (RCTs) of influenza vaccination compared with placebo or no treatment in participants with or without cardiovascular disease, assessing cardiovascular death or non-fatal cardiovascular events. We used standard methodological procedures as expected by The Cochrane Collaboration. We carried out meta-analyses only for cardiovascular death, as other outcomes were reported too infrequently. We expressed effect sizes as risk ratios (RRs), and we used random-effects models. We included eight trials of influenza vaccination compared with placebo or no vaccination, with 12,029 participants receiving at least one vaccination or control treatment. We included six new studies (n = 11,251), in addition to the two included in the previous version of the review. Four of these trials (n = 10,347) focused on prevention of influenza in the general or elderly population and reported cardiovascular outcomes among their safety analyses; four trials (n = 1682) focused on prevention of

  13. Cardiovascular malformations in infants of diabetic mothers

    OpenAIRE

    Wren, C; Birrell, G; Hawthorne, G

    2003-01-01

    Objective: To compare the prevalence at live birth and the spectrum of cardiovascular malformations in infants born to diabetic mothers with pre-existing diabetes with that in infants of non-diabetic mothers.

  14. Localized Scleroderma, Systemic Sclerosis and Cardiovascular Risk

    DEFF Research Database (Denmark)

    Hesselvig, Jeanette Halskou; Kofoed, Kristian; Wu, Jashin J

    2018-01-01

    Recent findings indicate that patients with systemic sclerosis have an increased risk of cardiovascular disease. To determine whether patients with systemic sclerosis or localized scleroderma are at increased risk of cardiovascular disease, a cohort study of the entire Danish population aged ≥ 18...... and ≤ 100 years was conducted, followed from 1997 to 2011 by individual-level linkage of nationwide registries. Multivariable adjusted Cox regression models were used to estimate the hazard ratios (HRs) for a composite cardiovascular disease endpoint. A total of 697 patients with localized scleroderma and 1......,962 patients with systemic sclerosis were identified and compared with 5,428,380 people in the reference population. In systemic sclerosis, the adjusted HR was 2.22 (95% confidence interval 1.99-2.48). No association was seen between patients with localized scleroderma and cardiovascular disease. In conclusion...

  15. Disease Human - MDC_CardiovascularMortality2006

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Polygon feature class based on Zip Code boundaries showing the rate of deaths due to major cardiovascular diseases per 1000 residents of Miami-Dade County in 2006.

  16. From ARB to ARNI in Cardiovascular Control

    NARCIS (Netherlands)

    Uijl, E. (Estrellita); L.C.W. Roksnoer (Lodi); E.J. Hoorn (Ewout); A.H.J. Danser (Jan)

    2016-01-01

    textabstractCoexistence of hypertension, diabetes mellitus and chronic kidney disease synergistically aggravates the risk of cardiovascular and renal morbidity and mortality. These high-risk, multi-morbid patient populations benefit less from currently available anti-hypertensive treatment.

  17. Discontinued drugs in 2012: cardiovascular drugs.

    Science.gov (United States)

    Zhao, Hong-Ping; Jiang, Hong-Min; Xiang, Bing-Ren

    2013-11-01

    The continued high rate of cardiovascular morbidity and mortality has attracted wide concern and great attention of pharmaceutical industry. In order to reduce the attrition of cardiovascular drug R&D, it might be helpful recapitulating previous failures and identifying the potential factors to success. This perspective mainly analyses the 30 cardiovascular drugs dropped from clinical development in 2012. Reasons causing the termination of the cardiovascular drugs in the past 5 years are also tabulated and analysed. The analysis shows that the attrition is highest in Phase II trials and financial and strategic factors and lack of clinical efficacy are the principal reasons for these disappointments. To solve the four problems (The 'better than the Beatles' problem, the 'cautious regulator' problem, the 'throw money at it' tendency and the 'basic researchbrute force' bias) is recommended as the main measure to increase the number and quality of approvable products.

  18. The gut microbiome in atherosclerotic cardiovascular disease

    DEFF Research Database (Denmark)

    Jie, Zhuye; Xia, Huihua; Zhong, Shi-Long

    2017-01-01

    The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals...... with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular...... health. Although drug treatment represents a confounding factor, ACVD status, and not current drug use, is the major distinguishing feature in this cohort. We identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes...

  19. Cardiovascular risk factors in subjects with psoriasis

    DEFF Research Database (Denmark)

    Jensen, Peter; Thyssen, Jacob P; Zachariae, Claus

    2013-01-01

    Background Epidemiological data have established an association between cardiovascular disease and psoriasis. Only one general population study has so far compared prevalences of cardiovascular risk factors among subjects with psoriasis and control subjects. We aimed to determine the prevalence...... of cardiovascular risk factors in subjects with and without psoriasis in the general population. Methods During 2006-2008, a cross-sectional study was performed in the general population in Copenhagen, Denmark. A total of 3471 subjects participated in a general health examination that included assessment of current...... between subjects with and without psoriasis with regard to traditional cardiovascular risk factors. Conclusions Our results contrast with the hitherto-reported increased prevalence of metabolic syndrome in subjects with psoriasis in the general US population. However, our results agree with those of other...

  20. Lipoprotein metabolism indicators improve cardiovascular risk prediction

    NARCIS (Netherlands)

    Schalkwijk, D.B. van; Graaf, A.A. de; Tsivtsivadze, E.; Parnell, L.D.; Werff-van der Vat, B.J.C. van der; Ommen, B. van; Greef, J. van der; Ordovás, J.M.

    2014-01-01

    Background: Cardiovascular disease risk increases when lipoprotein metabolism is dysfunctional. We have developed a computational model able to derive indicators of lipoprotein production, lipolysis, and uptake processes from a single lipoprotein profile measurement. This is the first study to

  1. 459 Preventing Cardiovascular Disease Risk Factors through ...

    African Journals Online (AJOL)

    FIRST LADY

    2011-01-18

    Jan 18, 2011 ... injury. Risk factors may be considered as characteristic indicators ... by examining the cardiovascular risk factors that are related to various forms .... Cross country race, Handball, Jogging, Rope jumping, Running Soccer,.

  2. Cardiovascular fitness strengthening using portable device.

    Science.gov (United States)

    Alqudah, Hamzah; Kai Cao; Tao Zhang; Haddad, Azzam; Su, Steven; Celler, Branko; Nguyen, Hung T

    2016-08-01

    The paper describes a reliable and valid Portable Exercise Monitoring system developed using TI eZ430-Chronos watch, which can control the exercise intensity through audio stimulation in order to increase the Cardiovascular fitness strengthening.

  3. CARDIOVASCULAR DISORDERS WITH HYPOTHYROIDISM AND ADIPOKINES

    Directory of Open Access Journals (Sweden)

    S. Ye. Myasoyedova

    2015-01-01

    Full Text Available The article describes the mechanisms of development of cardiovascular disorders and dyslipidemia with hypothyroidism. Reference data are presented that are devoted to the study of adipokines content with hypothyroidism and their effect on echocardiographic indicators.

  4. Contemporary protease inhibitors and cardiovascular risk

    DEFF Research Database (Denmark)

    Lundgren, Jens; Mocroft, Amanda; Ryom, Lene

    2018-01-01

    PURPOSE OF REVIEW: To review the evidence linking use of HIV protease inhibitors with excess risk of cardiovascular disease (CVD) in HIV+ populations. RECENT FINDINGS: For the two contemporary most frequently used protease inhibitors, darunavir and atazanavir [both pharmacologically boosted...

  5. Acupuncture's Cardiovascular Actions: A Mechanistic Perspective

    OpenAIRE

    Longhurst, John

    2013-01-01

    Over the last several decades, there has been an explosion of articles on acupuncture, including studies that have begun to explore mechanisms underlying its analgesic and cardiovascular actions. Modulation of cardiovascular function is most effective during manual and low-frequency, low-intensity electroacupuncture (EA) at a select set of acupoints situated along meridians located over deep somatic nerves on the upper and lower extremities. Stimulation at these acupoints activates underlying...

  6. Atlas de riesgo cardiovascular en Asturias, 2014

    OpenAIRE

    Margolles, Mario; Saiz, Roberto; Margolles, Pedro; García, Eva; Donate, Ignacio

    2015-01-01

    deepen the knowledge of levels of cardiovascular risk (CVR) to to implement measures to improve the promotion and prevention and comprehensive assistance. our aims to increase information on RCV levels in Asturias and facilitate health planning. Consejeria de Sanidad. Gobierno del Principado de Asturias II Congreso Iberoamericano de Epidemiología y Salud Pública profundizar en el conocimiento de los niveles de riesgo cardiovascular (RCV) para poder aplicar med...

  7. Cardiovascular diseases in dental practice : Practical considerations

    OpenAIRE

    Margaix Muñoz, María; Jiménez Soriano, Yolanda; Poveda Roda, Rafael; Sarrión Pérez, María Gracia

    2008-01-01

    Coronary heart disease is the principal cause of death in the industrialized world. Its most serious expression, acute myocardial infarction, causes 7.2 million deaths each year worldwide, and it is estimated that 20% of all people will suffer heart failure in the course of their lifetime. The control of risk cardiovascular factors, including arterial hypertension, obesity and diabetes mellitus is the best way to prevent such diseases. The most frequent and serious cardiovascular emergenc...

  8. Farmacogenómica: Aplicaciones cardiovasculares

    Directory of Open Access Journals (Sweden)

    Luis Quiñones S., PH.D.

    2015-03-01

    Este trabajo pretende dar una visión general acerca de farmacogenómica cardiovascular y la posibilidad de utilizar, en la consulta clínica, herramientas genéticas para apoyar la decisión farmacoterapéutica, con el objeto de mejorar la respuesta al tratamiento de enfermedades cardiovasculares, un paso hacia la medicina personalizada en Chile.

  9. Relationship between Inflammation and Cardiovascular Diseases

    OpenAIRE

    Riddhi Patel; Henish Patel; Rachana Sarawade

    2013-01-01

    Inflammation is a part of complex biological response of vascular tissue to harmful stimuli such as pathogens, damaged cells or irritants. Recent advance in basic science have established a fundamental role for inflammation immediating all stages of cardiovascular diseases from initiation, progression and complications. Inflammation is thread linking to cardiovascular diseases. Clinical studies have shown that this emerging biology of inflammation play important role in pathogenesis of acute ...

  10. Cardiovascular issues in boxing and contact sports.

    Science.gov (United States)

    Siegel, Stephen A

    2009-10-01

    Despite the inherent risks associated with exercise in general and boxing in particular, the sport has had a limited number of catastrophic cardiovascular events. Screening should be based on risks involved and become more extensive with the advancement of the athlete. Anatomic and electrophysiologic risks need to be assessed and may preclude participation with resultant life style and economic complications. There should be adequate preparation for the rare potential cardiovascular complication at all events, with the ability to rapidly assess and treat arrhythmias.

  11. 21 CFR 870.3375 - Cardiovascular intravascular filter.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cardiovascular intravascular filter. 870.3375... Cardiovascular intravascular filter. (a) Identification. A cardiovascular intravascular filter is an implant that... and Revision of 2/12/90 (K90-1)” and (ii) “Guidance for Cardiovascular Intravascular Filter 510(k...

  12. Acute effects on cardiovascular oscillations during controlled slow yogic breathing

    Directory of Open Access Journals (Sweden)

    Om Lata Bhagat

    2017-01-01

    Interpretation & conclusions: Significant increase in cardiovascular oscillations and baroreflex recruitments during-ANB suggested a dynamic interaction between respiratory and cardiovascular system. Enhanced phasic relationship with some delay indicated the complexity of the system. It indicated that respiratory and cardiovascular oscillations were coupled through multiple regulatory mechanisms, such as mechanical coupling, baroreflex and central cardiovascular control.

  13. [Air pollution and cardiovascular disease in Trondheim].

    Science.gov (United States)

    Mannsåker, Bård; Vikan, Torkel; Holme, Jonas

    2004-05-20

    There is some evidence linking air pollution to cardiovascular morbidity. Our aim was to examine whether there is a correlation between air pollution and cardiovascular morbidity in the city of Trondheim, Norway. We compared the mean daily number of admissions for cardiovascular disease to the St. Olav University hospital on days with relatively low and high levels of PM10 (1993-2001), PM2,5, NO, NO2, SO2, O3, toluene and paraxylene (1998-2001). A time series analysis was carried out to see how day-to-day variations in concentrations of air pollutants correlated with the number of hospitalizations for cardiovascular disease. In the bivariate analysis, the mean daily number of hospitalizations was found to be significantly higher (p < 0.05) on days with NO and NO2 levels above the 80 th percentile (57.6 microg/m3 and 43.1 microg/m3, respectively) than on days with pollutant levels below the 20th percentile (11.3 microg/m3 and 16.9 microg/m3, respectively). Time series analysis did not show any statistically significant correlation between day-to-day variations in air pollution and hospital admissions for cardiovascular disease. The findings regarding NO2 and NO indicate that exposure to gases and/or ultra-small particles from diesel exhaust may influence cardiovascular morbidity.

  14. Would male hormonal contraceptives affect cardiovascular risk?

    Directory of Open Access Journals (Sweden)

    Michael Zitzmann

    2018-01-01

    Full Text Available The aim of hormonal male contraception is to prevent unintended pregnancies by suppressing spermatogenesis. Hormonal male contraception is based on the principle that exogenous administration of androgens and other hormones such as progestins suppress circulating gonadotropin concentrations, decreasing testicular Leydig cell and Sertoli cell activity and spermatogenesis. In order to achieve more complete suppression of circulating gonadotropins and spermatogenesis, a progestin has been added testosterone to the most recent efficacy trials of hormonal male contraceptives. This review focusses on the potential effects of male hormonal contraceptives on cardiovascular risk factors, lipids and body composition, mainly in the target group of younger to middle-aged men. Present data suggest that hormonal male contraception can be reasonably regarded as safe in terms of cardiovascular risk. However, as all trials have been relatively short (< 3 years, a final statement regarding the cardiovascular safety of hormonal male contraception, especially in long-term use, cannot be made. Older men with at high risk of cardiovascular event might not be good candidates for hormonal male contraception. The potential adverse effects of hormonal contraceptives on cardiovascular risk appear to depend greatly on the choice of the progestin in regimens for hormonal male contraceptives. In the development of prospective hormonal male contraception, data on longer-term cardiovascular safety will be essential.

  15. Cardiovascular risk factors and collateral artery formation.

    Science.gov (United States)

    de Groot, D; Pasterkamp, G; Hoefer, I E

    2009-12-01

    Arterial lumen narrowing and vascular occlusion is the actual cause of morbidity and mortality in atherosclerotic disease. Collateral artery formation (arteriogenesis) refers to an active remodelling of non-functional vascular anastomoses to functional collateral arteries, capable to bypass the site of obstruction and preserve the tissue that is jeopardized by ischaemia. Hemodynamic forces such as shear stress and wall stress play a pivotal role in collateral artery formation, accompanied by the expression of various cytokines and invasion of circulating leucocytes. Arteriogenesis hence represents an important compensatory mechanism for atherosclerotic vessel occlusion. As arteriogenesis mostly occurs when lumen narrowing by atherosclerotic plaques takes place, presence of cardiovascular risk factors (e.g. hypertension, hypercholesterolaemia and diabetes) is highly likely. Risk factors for atherosclerotic disease affect collateral artery growth directly and indirectly by altering hemodynamic forces or influencing cellular function and proliferation. Adequate collateralization varies significantly among atherosclerotic patients, some profit from the presence of extensive collateral networks, whereas others do not. Cardiovascular risk factors could increase the risk of adverse cardiovascular events in certain patients because of the reduced protection through an alternative vascular network. Likewise, drugs primarily thought to control cardiovascular risk factors might contribute or counteract collateral artery growth. This review summarizes current knowledge on the influence of cardiovascular risk factors and the effects of cardiovascular medication on the development of collateral vessels in experimental and clinical studies.

  16. Human Cardiovascular Adaptation to Weightlessness

    Science.gov (United States)

    Norsk, Peter

    2011-01-01

    Entering weightlessness (0 G) induces immediately a shift of blood and fluid from the lower to the upper parts of the body inducing expansion of the cardiac chambers (Bungo et al. 1986; Charles & Lathers 1991; Videbaek & Norsk 1997). For many years the effects of sudden 0 G on central venous pressure (CVP) was discussed, and it puzzled researchers that CVP compared to the 1-G supine position decreased during the initial hours of spaceflight, when at the same time left atrial diameter increased (Buckey et al. 1996). By measuring esophageal pressure as an estimate of inter-pleural pressure, it was later shown that this pressure decreases more than CVP does during 0 G induced by parabolic flights (Videbaek & Norsk 1997). Thus, transmural CVP is increased, which distends the cardiac chambers. This unique lung-heart interaction whereby 1) inter-pleural pressure decreases and 2) central blood volume is expanded is unique for 0 G. Because transmural CVP is increased, stroke volume increases according to the law of Frank-Starling leading to an increase in cardiac output, which is maintained increased during months of 0 G in space to levels of some 25% above that of the 1-G seated position (Norsk unpublished). Simultaneously, sympathetic nervous activity is at the level of the upright 1-G posture, which is difficult to explain based on the high stroke volume and decreased blood pressure and systemic vascular resistance. This paradox should be explored and the mechanisms revealed, because it might have implications for estimating the cardiovascular risk of travelling in space.

  17. Cardiovascular risk factors in children.

    Science.gov (United States)

    Fraporti, Marisete Inês; Scherer Adami, Fernanda; Dutra Rosolen, Michele

    2017-10-01

    Systemic hypertension is one of the main risk factors for cardiovascular disease (CVD). Early diagnosis and treatment of hypertension in childhood can potentially have a significant impact on future adverse outcomes. To investigate the relationship of diastolic (DBP) and systolic blood pressure (SBP) with anthropometric data and area of residence of children in municipalities of Rio Grande do Sul state, Brazil. This is a cross-sectional study of 709 children between six and nine years of age. Blood pressure, weight, height and waist circumference (WC) were measured. Statistical tests had a maximum significance level of 5% (p≤0.05) and the software used was SPSS version 13.0. Obesity was significantly associated with pre-hypertension, and stage 1 and 2 hypertension as assessed by DBP and SBP (≤0.05); high WC was significantly associated with a classification of pre-hypertension and stage 1 hypertension based on DBP and a classification of stage 1 and 2 hypertension based on SBP (≤0.01). Children living in urban areas had significantly higher mean SBP than those living in rural areas. Those with high WC presented higher SBP and DBP compared to children with normal WC. Obese children showed higher mean SBP and DBP compared to those who were overweight or normal weight and mean SBP and DBP also increased with older age and higher mean body mass index and WC. Copyright © 2017 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.

  18. Practicality of cardiovascular risk functions

    Directory of Open Access Journals (Sweden)

    Jaume Marrugat

    2016-12-01

    Full Text Available Resumen Las estrategias de prevención de las enfermedades cardiovasculares necesitan refinamiento porque su incidencia se reduce muy lentamente. Las funciones de riesgo incorporaron los factores de riesgo clásicos (edad, sexo, consumo de tabaco, diabetes, presión arterial, y perfil lipídico básico en cohortes seguidas generalmente más de 10 años. Son razonablemente precisas para el cribado poblacional del riesgo de enfermedad coronaria exigido en las guías de práctica clínica. Clasifican a los pacientes en niveles de riesgo para concentrar un mayor esfuerzo terapéutico y preventivo en los de mayor riesgo, y en los que el número necesario a tratar y el coste-efectividad son óptimos. Proporcionar el riesgo relativo y de la edad vascular al paciente, le motiva a cumplir seguir tratamientos y estilos de vida. Alrededor del 20% de la población de 35 a 74 años tiene riesgo intermedio y requiere reclasificación a alto o bajo riesgo porque concentra 35% de eventos poblacionales de enfermedad coronaria. Se ensayan nuevos biomarcadores (bioquímicos, genéticos o de imagen para mejorar la precisión de las predicciones. Si los equipos informáticos de los sistemas de salud incorporaran el cálculo automatizado del riesgo se facilitaría la tarea preventiva del personal asistencial.

  19. Prevalência de fatores de risco para Síndrome Coronariana aguda em pacientes atendidos em uma emergência Prevalencia de los factores de riesgo para el Síndrome Coronario agudo en los pacientes tratados en una emergencia Prevalence of risk factors for acute Coronary Syndrome in patients treated in an emergency

    Directory of Open Access Journals (Sweden)

    Karine Franke Lemos

    2010-03-01

    Full Text Available Objetivou-se caracterizar o perfil do paciente portador de Síndrome Coronária Aguda (SCA atendido em um serviço de emergência de Porto Alegre, Rio Grande do Sul, no que se refere aos fatores de risco. Estudo de prevalência entre agosto de 2007 e fevereiro de 2008. Para coleta de dados, foi utilizado um questionário, consulta ao prontuário e aferição de medidas antropométricas. Foram avaliados 152 pacientes com SCA, 63,8% do sexo masculino, idade média de 61±10,26 anos. Com diagnóstico de infarto agudo do miocárdio sem supradesnivelamento de ST em 50,7%, infarto agudo do miocárdio com supradesnivelamento de ST em 14,5% e angina instável em 34,9%. Os fatores de risco foram: sedentarismo (86,8%; sobrepeso e obesidade (77%; hipertensão arterial sistêmica (75,7%; história familiar (56,6%; estresse (52,6%; dislipidemia (44,7%; diabete mellitus (40,1%; tabagismo (39,5%; e ingesta de álcool (14,4%. Constatou-se uma alta prevalência de fatores de risco para SCA, necessitando de programas de educação em saúde, visando reduzir a morbi-mortalidade.Propusimos caracterizar el perfil de pacientes portador del Síndrome Coronariana Agudo (SCA en un servicio de emergencia de Porto Alegre, Rio Grande do Sul, Brasil, en lo que se refiere a los factores de riesgo. Estudio de prevalencia entre agosto/2007 y febrero/2008. Para la colecta de datos, fue utilizado un cuestionario, consulta al prontuario y contraste de medidas antropométricas. Fueron avaliados 152 pacientes con SCA, 63,8% de sexo masculino, edad media de 61 ± 10,26 años. Con diagnóstico de infarto agudo del miocardio sin elevación ST en 50,7%, infarto agudo del miocardio con elevación ST en 14,5% y angina inestable 34,9%. Los factores de riesgo fueron, sedentarismo (86,8%; sobrepeso y obesidad (77%; hipertensión arterial sistémica (75,7%; histórico familiar (56,6%; estrés (52,6%; dislipidemía (44,7%; diabetes mellitus (40,1%; tabaquismo (39,5%; ingetión de alcohol(14

  20. Acute Cardiovascular Care Association Position Paper on Intensive Cardiovascular Care Units

    DEFF Research Database (Denmark)

    Bonnefoy-Cudraz, Eric; Bueno, Hector; Casella, Gianni

    2018-01-01

    , the recommended management structure, the optimal number of staff, the need for specially trained cardiologists and cardiovascular nurses, the desired equipment and architecture, and the interaction with other departments in the hospital and other intensive cardiovascular care units in the region...

  1. Ideal cardiovascular health and risk of cardiovascular events in the EPIC-Norfolk prospective population study

    NARCIS (Netherlands)

    Lachman, Sangeeta; Peters, Ron Jg; Lentjes, Marleen Ah; Mulligan, Angela A.; Luben, Robert N.; Wareham, Nicholas J.; Khaw, Kay-Tee; Boekholdt, S. Matthijs

    2016-01-01

    The American Heart Association has prioritised seven cardiovascular health metrics to reduce the cardiovascular burden, including: body mass index, healthy diet, physical activity, smoking status, blood pressure, glycated haemoglobin A1c and total cholesterol. The aim of the current study was to

  2. Multifactorial Prevention of Cardiovascular Disease in Patients with Hypertension : the Cardiovascular Polypill

    NARCIS (Netherlands)

    Lafeber, M; Spiering, W; Visseren, F L J; Grobbee, D E

    2016-01-01

    Hypertension is a major, if not the most important, contributor to the disease burden and premature death globally which is largely related to cardiovascular disease. In both the primary and the secondary preventions of cardiovascular disease, blood pressure (BP) targets are often not achieved which

  3. Tratamento cirúrgico da comunicação interventricular pós infarto agudo do miocárdio: conduta atual Present surgical management of post-myocardial infarction ventricular septal rupture

    Directory of Open Access Journals (Sweden)

    Luís Alberto Dallan

    1989-04-01

    Full Text Available Os autores descrevem sua experiência com o tratamento cirúrgico de 42 pacientes portadores de comunicação interventricular (CIV pós infarto agudo do miocárdio (IAM. Destacam a elevada mortalidade cirúrgica nos pacientes com choque cardiogênico instalado (66,6% em relação aos demais (9,5%. A observação de descompensações súbitas em pacientes hemodinâmicamente estáveis tem levado à indicação cirúrgica precoce, se possível, assim que estabelecido o diagnóstico da rotura do septo interventricular (RSI. O comprometimento de múltiplas artérias coronárias e faixas etárias elevadas foram considerados fatores agravantes no prognóstico cirúrgico. O mesmo não ocorreu com a relação fluxo pulmonar/sistêmico e shunt E-D, que não guardaram relação com a mortalidade. A técnica de exposição de ambas as cavidades ventriculares e reforço das 2 faces do septo roto com tecido biológico tem fornecido resultados gratificantes na correção da RSI, especialmente de localização posterior.The authors describe the experience with surgical treatment of 42 patients with ventricular septal rupture (VSR in post acute myocardial infarction (AMI. They showed increased mortality in patients with cardiogenic shock (66.6% with respect to others (9.5%. Sudden descompensations in patients hemodinamically stable were indications to early surgeries, if possible when the diagnosis of ventricular septum rupture (VSR was made. The compromise of multiple coronary arteries and advanced age were considered as aggravating factors in the prognosis of surgery. The same prognosis did not occur regarding pulmonary/systemic flow and shunt E-D. The technique of exposure in both ventricular cavity and reinforcement in the both sides of the ruptured septum with biological tissue offered good results in the correction of posterior VSR.

  4. Efeito agudo da crioterapia e diatermia na flexibilidade e força muscular de isquiotibiais = Acute effect of cryotherapy and diathermy in the hamstring flexibility and muscle strength

    Directory of Open Access Journals (Sweden)

    Dohnert, Marcelo Baptista

    2017-01-01

    Full Text Available Objetivo: Verificar o efeito agudo da crioterapia e da diatermia por ondas curtas na flexibilidade e força muscular de isquiotibiais de adultas jovens. Materiais e Métodos: Quarenta e cinco voluntárias foram randomizadas em grupo controle, grupo crioterapia e grupo diatermia por ondas curtas. Os sujeitos foram submetidos a uma única aplicação de crioterapia ou diatermia por ondas curtas. Foram avaliadas, pré e pós intervenção, a flexibilidade através do banco de Wells e do ângulo de extensão ativa do joelho, e a força muscular através da dinamometria. As variáveis foram analisadas por meio do teste t de Student e ANOVA. Resultados: Verificou-se um aumento significativo da flexibilidade dos isquiotibiais, tanto através do banco de Wells (24,50±6,88 cm para 26,87±8,02 cm (p=0,002, quanto na extensão ativa do joelho (162,60±7,76 graus para 165,53 ± 6,38 graus (p=0,015 no grupo diatermia. O grupo crioterapia mostrou melhora da flexibilidade no banco de Wells (23,27±6,33 cm para 25,53±6,13 cm (p=0,002. Não ocorreu aumento significativo da força muscular em nenhum dos grupos de intervenção. Não foi verificada diferença entre os grupos do estudo. Conclusão: Tanto a diatermia quanto a crioterapia melhoraram, de forma aguda, a flexibilidade dos isquiotibiais em mulheres adultas jovens e saudáveis. A termoterapia através da diatermia por ondas curtas mostrou-se mais efetiva nessa melhora. Ambos os recursos não alteraram a força muscular produzida pelos isquiotibiais

  5. COMPARACIÓN MEDIANTE UN ESTUDIO PROSPECTIVO Y ALEATORIZADO DE DOS MÉTODOS DE REPOSICIÓN EN UNIDADES DE ENFERMERÍA EN HOSPITALIZACIÓN POLIVALENTE DE AGUDOS CON ALMACENAMIENTO MEDIANTE DOBLE CAJETÍN

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    José Luis Bernal

    2017-01-01

    Full Text Available Fundamentos: Los sistemas de almacenamiento mediante doble ca - jetín aumentan la satisfacción del personal de enfermería y disminuyen los inventarios, pero no se conocen las implicaciones de que sea el personal de logística quién determine la necesidad de reposición. El objetivo de este estudio fue evaluar si encomendar dicha responsabilidad a este personal en unidades de hospitalización polivalente de agudos entraña un mayor riesgo de pedidos extraordinarios. Métodos: Se realizó un estudio experimental, prospectivo aleatorizado con enmascaramiento. Los pedidos extraordinarios se consideraron variable de respuesta; los correspondientes a valoraciones del personal de logística se incluyeron en el grupo de intervención y los del personal de enfermería, en el de control. La concordancia entre observadores se analizó con el método de Bland- Altman; la diferencia entre grupos, con la U de Mann-Whitney y se calculó la incidencia acumulada de pedidos extraordinarios y su riesgo relativo. Resultados: La cantidad media solicitada por el personal de logística y el de enfermería fue 29,9 (DE:167,4 y 36 (DE:190 unidades respectiva - mente, la diferencia media entre observadores fue 6,11 (DE:128,95 uni - dades y no se encontraron diferencias significativas entre los grupos (p = 0,430. La incidencia de pedidos extraordinarios fue 0,64% en el grupo de intervención y 0,15% en el de control; el riesgo relativo, 2,31 (0,83 – 6,48 y el número de casos necesarios para un pedido extraordinario, 516. Conclusión: El riesgo de pedidos extraordinarios en unidades de hos - pitalización con almacenamiento mediante doble cajetín no está asociado con la categoría profesional del personal que identifica las necesidades de reposición.

  6. Efeitos agudos laringológicos e vocais da radioiodoterapia em pacientes com hipertireoidismo por doença de Basedow Graves Acute effects of radioiodine therapy on the voice and larynx of Basedow-Graves patients

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    Roberta Werlang Isolan-Cury

    2008-04-01

    Full Text Available A Doença de Graves constitui a forma mais comum de hipertireoidismo e três abordagens terapêuticas são atualmente utilizadas: uso de medicamentos antitireoideanos, cirurgia e iodo radioativo (I 131. Os efeitos do o I 131 e a indução precoce de hipotireoidismo são conseqüências da destruição induzida do I131 sobre o parênquima tireoideano. São poucos relatos encontrados na literatura acerca dos efeitos da radioioterapia sobre a laringe e conseqüentemente na produção vocal. OBJETIVO: Avaliar os efeitos agudos sobre a voz da radioiodoterapia em pacientes com hipertireoidismo por Doença de Basedow Graves. MATERIAL E MÉTODO: Estudo de corte contemporâneo longitudinal, prospectivo. Procedimentos: Investigação vocal, mensuração do tempo máximo fonatório de /a/ e relação s/z, análise freqüência fundamental (Software Praat, laringoscopia e análise perceptivo-auditiva em três momentos: pré-dose, 4 dias e 20 dias pós dose. Momentos baseados no perfil inflamatório do tecido tireoideano. RESULTADOS: Não houve mudanças estatisticamente significantes nos aspectos vocais e laringológicos nos três momentos avaliados. CONCLUSÃO: A radioiodoterapia não afeta a qualidade vocal.Graves's disease is the most common cause of hyperthyroidism. There are three current therapeutic options: anti-thyroid medication, surgery, and radioactive iodine (I 131. There are few data in the literature regarding the effects of radioiodine therapy on the larynx and voice. The aim and the AIM: os this study was: to assess the effect of radioiodine therapy on the voice of Basedow-Graves patients. MATERIAL AND METHOD: A prospective study was done. Following the diagnosis of Grave's disease, patients underwent investigation of their voice, measurement of maximum phonatory time (/a/ and the s/z ratio, fundamental frequency analysis (Praat software, laringoscopy and (perceptive-auditory analysis in three different conditions: pre-treatment, 4 days, and

  7. Modificaciones funcionales ventilatorias en pacientes con anemia drepanocítica y antecedentes de síndrome torácico agudo Respiratory functional changes in patients with sickle cell anemia and history of acute chest synd

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    José René Mesa Cuervo

    2002-08-01

    Full Text Available Se realizó un estudio descriptivo prospectivo para evaluar la función ventilatoria en pacientes con anemia drepanocítica (AD y antecedentes de síndrome torácico agudo (STA atendidos en consulta externa del Instituto de Hematología e Inmunología de septiembre de 1999 a septiembre del 2000. El universo de estudio se dividió en 2 grupos: el primero constituido por 36 pacientes con el diagnóstico de AD y antecedente de STA, y el segundo por 17, con una distribución por edades y sexos similar al anterior con AD, pero sin el antecedente de STA. A todos los pacientes seleccionados se les realizaron las pruebas funcionales ventilatorias (PFV siguiendo criterios internacionales. La disfunción ventilatoria restrictiva se observó en todos los pacientes con AD independiente del antecedente de STA, sin embargo, el antecedente de 2 y más STA mostró los mayores porcentajes. La edad y el sexo no influyeron en los resultados espirométicosA prospective descriptive study was made to evaluate the respiratory function in patients with sickle cell anemia and history of acute chest syndrome seen at the outpatient service of the Institute of Hematology and Immunology from September 1999 to September 2000. The universe of study was divided into 2 groups: the first was made up of 36 patients diagnosed with sickle cell anemia and history of acute thoracic syndrome; and the second included 17 patients with sickle cell anemia, distributed by age and sex in a similar way as in the first one, but without history of acute chest syndrome. All the selected patients were applied the respiratory function tests according to the international criteria. Restrictive respiratory dysfunction was observed in all patients with sickle cell anemia regardless of their history of acute chest syndrome; however, the history of two or more syndromes showed the highest percentages. Age and sex did not influence the results

  8. Manifestaciones clínicas y hallazgos de laboratorio de una serie de casos febriles agudos con diagnóstico presuntivo de infección por el virus dengue. Quindío (Colombia

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    Carlos Andrés Rodríguez-Salazar

    Full Text Available Objetivo: Describir las manifestaciones clínicas y hallazgos de laboratorio de una serie de casos febriles agudos con diagnóstico presuntivo de infección por el virus dengue. en Quindío (Colombia. Materiales y métodos: Se realizó un estudio de corte transversal, en pacientes con sospecha clínica de dengue en el periodo comprendido entre enero y agosto de 2013, en algunos centros hospitalarios del departamento del Quindío. Se tomaron muestras de sangre para diagnóstico de dengue, leptospira, malaria, hepatitis B, y rickettsiosis. Como pruebas confirmatorias para dengue se realizó aislamiento viral en células C6/36HT y serotipificación para dengue por RTPCR; pruebas de función hepática, cuadro hemático y niveles de citocinas. Resultados: Se caracterizaron 149 casos, de los cuales el 43% presentaron infección por dengue, 4% leptospira, 6,8% rickettsias, un caso de malaria y uno de hepatitis B. En 5 casos se logró el aislamiento del DENV2 y DENV3. Mediante la RT-PCR, se evidenció cocirculación de serotipos 2, 3, 4. Se encontró que las enzimas AST/ALT, el conteo de plaquetas, la erupción y el dolor abdominal fueron marcadores característicos de la infección por dengue, mientras la ictericia y el dolor lumbar se correlacionaron con la leptospirosis. Los valores de citocinas mostraron que la IL-10, TNF α variaron significativamente en casos con dengue frente a otros diagnósticos, y la IL-17 a presentó diferencias significativas en individuos con dengue grave. Conclusiones: El dengue se confirmó como causa etiológica importante de síndrome febril icterohemorrágico en el departamento del Quindío, pero la leptospirosis y la rickettsiosis tienen también una participación importante. Sin embargo, en el 44% de los casos fueron catalogados como síndrome febril indeterminado.

  9. Oxytocin is a cardiovascular hormone

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    Gutkowska J.

    2000-01-01

    Full Text Available Oxytocin (OT, a nonapeptide, was the first hormone to have its biological activities established and chemical structure determined. It was believed that OT is released from hypothalamic nerve terminals of the posterior hypophysis into the circulation where it stimulates uterine contractions during parturition, and milk ejection during lactation. However, equivalent concentrations of OT were found in the male hypophysis, and similar stimuli of OT release were determined for both sexes, suggesting other physiological functions. Indeed, recent studies indicate that OT is involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of cardiovascular functions. It has long been known that OT induces natriuresis and causes a fall in mean arterial pressure, both after acute and chronic treatment, but the mechanism was not clear. The discovery of the natriuretic family shed new light on this matter. Atrial natriuretic peptide (ANP, a potent natriuretic and vasorelaxant hormone, originally isolated from rat atria, has been found at other sites, including the brain. Blood volume expansion causes ANP release that is believed to be important in the induction of natriuresis and diuresis, which in turn act to reduce the increase in blood volume. Neurohypophysectomy totally abolishes the ANP response to volume expansion. This indicates that one of the major hypophyseal peptides is responsible for ANP release. The role of ANP in OT-induced natriuresis was evaluated, and we hypothesized that the cardio-renal effects of OT are mediated by the release of ANP from the heart. To support this hypothesis, we have demonstrated the presence and synthesis of OT receptors in all heart compartments and the vasculature. The functionality of these receptors has been established by the ability of OT to induce ANP release from perfused heart or atrial slices. Furthermore, we have shown that the heart and large vessels

  10. Complicações cardiovasculares em usuário de cocaína: relato de caso Cardiovascular complications related to cocaine use: case report

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    Fernanda Martins Gazoni

    2006-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A cocaína é uma droga ilícita amplamente utilizada e o seu uso tem sido associado a efeitos decorrentes da toxicidade aguda e crônica em praticamente todos os órgãos, particularmente no sistema cardiovascular. Este artigo visou descrever um caso de cardiomiopatia em paciente jovem usuário crônico de cocaína. RELATO DO CASO: Paciente do sexo masculino, 19 anos, usuário de cocaína por inalação e crack desde os 15 anos de idade. Foi internado em fevereiro de 2006 devido a dispnéia progressiva aos mínimos esforços e expectoração sanguinolenta. Ao exame físico apresentava edema nos membros inferiores, estase jugular e dispnéia em repouso. Foram observados no ecocardiograma: dilatação das quatro câmaras cardíacas, com hipocinesia difusa de ventrículo esquerdo (VE, trombo mural em VE de 17 mm e fração de ejeção de 12%. Realizada broncoscopia pulmonar que identificou sangramento em língula ativo, tratado com embolização. Após 48h do procedimento, o paciente manteve-se assintomático e sem expectoração sanguinolenta. Iniciado tratamento antitrombótico com warfarina e enoxaparina. A cineangiocoronariografia não evidenciou lesões obstrutivas e o paciente recebeu alta após melhora clínica. Re-internado em julho de 2006 com dor precordial de forte intensidade e dispnéia de repouso. Nova cineangiocoronariografia evidenciou oclusão de terço médio da artéria descendente anterior. CONCLUSÕES: Os efeitos agudos da cocaína freqüentemente motivam atendimento de emergência. Já as suas manifestações crônicas, como as doenças cardiovasculares, podem produzir alterações de difícil correlação futura ao seu consumo prévio. O uso prolongado da cocaína está relacionado à alteração da função sistólica ventricular esquerda por hipertrofia ou dilatação miocárdica, aterosclerose, disritmias cardíacas, apoptose de cardiomiócitos e lesão simpática.BACKGROUND AND OBJECTIVES

  11. Cardiovascular risk-benefit profile of sibutramine.

    Science.gov (United States)

    Scheen, A J

    2010-01-01

    Sibutramine is a combined norepinephrine and serotonin reuptake inhibitor used as an antiobesity agent to reduce appetite and promote weight loss in combination with diet and exercise. At a daily dose of 10-20 mg, it was initially considered to have a good safety profile, as it does not induce primary pulmonary hypertension or adverse effects on cardiac valves, in contrast to previous reports relating to some other antiobesity agents. However, it exerts disparate effects on cardiovascular risk factors. On the one hand, sibutramine may have antiatherogenic activities, as it improves insulin resistance, glucose metabolism, dyslipidemia, and inflammatory markers, with most of these effects resulting from weight loss rather than from an intrinsic effect of the drug. On the other hand, because of its specific mode of action, sibutramine exerts a peripheral sympathomimetic effect, which induces a moderate increase in heart rate and attenuates the reduction in BP attributable to weight loss or even slightly increases BP. It may also prolong the QT interval, an effect that could induce arrhythmias. Because of these complex effects, it is difficult to conclude what the final impact of sibutramine on cardiovascular outcomes might be. Sibutramine has been shown to exert favorable effects on some surrogate cardiovascular endpoints such as reduction of left ventricular hypertrophy and improvement of endothelial dysfunction. A good cardiovascular safety profile was demonstrated in numerous 1- to 2-year controlled trials, in both diabetic and nondiabetic well selected patients, as well as in several observational studies. However, since 2002, several cardiovascular adverse events (hypertension, tachycardia, arrhythmias, and myocardial infarction) have been reported in sibutramine-treated patients. This led to a contraindication of the use of this antiobesity agent in patients with established coronary heart disease, previous stroke, heart failure, or cardiac arrhythmias. SCOUT

  12. Mortality of mothers from cardiovascular and non-cardiovascular causes following pregnancy complications in first deliv