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Sample records for cardiac outflow tract

  1. Heart fossilization is possible and informs the evolution of cardiac outflow tract in vertebrates.

    Science.gov (United States)

    Maldanis, Lara; Carvalho, Murilo; Almeida, Mariana Ramos; Freitas, Francisco Idalécio; de Andrade, José Artur Ferreira Gomes; Nunes, Rafael Silva; Rochitte, Carlos Eduardo; Poppi, Ronei Jesus; Freitas, Raul Oliveira; Rodrigues, Fábio; Siljeström, Sandra; Lima, Frederico Alves; Galante, Douglas; Carvalho, Ismar S; Perez, Carlos Alberto; de Carvalho, Marcelo Rodrigues; Bettini, Jefferson; Fernandez, Vincent; Xavier-Neto, José

    2016-01-01

    Elucidating cardiac evolution has been frustrated by lack of fossils. One celebrated enigma in cardiac evolution involves the transition from a cardiac outflow tract dominated by a multi-valved conus arteriosus in basal actinopterygians, to an outflow tract commanded by the non-valved, elastic, bulbus arteriosus in higher actinopterygians. We demonstrate that cardiac preservation is possible in the extinct fish Rhacolepis buccalis from the Brazilian Cretaceous. Using X-ray synchrotron microtomography, we show that Rhacolepis fossils display hearts with a conus arteriosus containing at least five valve rows. This represents a transitional morphology between the primitive, multivalvar, conal condition and the derived, monovalvar, bulbar state of the outflow tract in modern actinopterygians. Our data rescue a long-lost cardiac phenotype (119-113 Ma) and suggest that outflow tract simplification in actinopterygians is compatible with a gradual, rather than a drastic saltation event. Overall, our results demonstrate the feasibility of studying cardiac evolution in fossils. PMID:27090087

  2. The right ventricular outflow tract in tetralogy of Fallot by preoperative cardiac angiography

    International Nuclear Information System (INIS)

    The underdevelopment of the right ventricular outflow tract is the essence among the main components of the tetralogy of Fallot. The detail and exact information about the states of the outflow tract in each patients with tetralogy of Fallot are very important to cardiac surgery. Fourteen patients of tetralogy of Fallet (12 undergone open heart surgery and 2, palliative) are available for their clinical chart and for cardiac angiography reviews. Analysis of them focusing the right ventricular outflow tract discloses the following results: 1. Average ratios of the systole to diastole of the pulmonary infundibulum are 0.63 ± 0.03 with the range of 0.44 to 1.0 cm P-A, and 0.64 ± 0.12 with the range of 0.5 to 0.83 on lateral projections. These results indicate relatively fixed infundibular stenosis of TOF. 2. Average infundibular systole to pulmonary bulb ratios are 0.24 ± 0.05 on P-A, and 0.36 ± 0.17 on lateral projections, which mean the underdeveloped and narrowed infundibulum more than the pulmonary truck in TOF. 3. Average pulmonary to aortic bulb ratios are 0.59 ± 0.01 on P-A, 0.54 ± 0.01 on lateral projections. These suggest hypoplasia of the pulmonary truck and anteriorly displaced conus septum and truncus septum from a developmental point of view. 4. The overriding degree of the aorta in our series are from 25% to 50% by Kjellberg et al classification.

  3. The right ventricular outflow tract in tetralogy of Fallot by preoperative cardiac angiography

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Chul; Lee, Jung Sook; Yoo, Soo Woong; Yu, Hoe Sung; Kim, Han Suk [National Medical Center, Seoul (Korea, Republic of)

    1979-06-15

    The underdevelopment of the right ventricular outflow tract is the essence among the main components of the tetralogy of Fallot. The detail and exact information about the states of the outflow tract in each patients with tetralogy of Fallot are very important to cardiac surgery. Fourteen patients of tetralogy of Fallet (12 undergone open heart surgery and 2, palliative) are available for their clinical chart and for cardiac angiography reviews. Analysis of them focusing the right ventricular outflow tract discloses the following results: 1. Average ratios of the systole to diastole of the pulmonary infundibulum are 0.63 {+-} 0.03 with the range of 0.44 to 1.0 cm P-A, and 0.64 {+-} 0.12 with the range of 0.5 to 0.83 on lateral projections. These results indicate relatively fixed infundibular stenosis of TOF. 2. Average infundibular systole to pulmonary bulb ratios are 0.24 {+-} 0.05 on P-A, and 0.36 {+-} 0.17 on lateral projections, which mean the underdeveloped and narrowed infundibulum more than the pulmonary truck in TOF. 3. Average pulmonary to aortic bulb ratios are 0.59 {+-} 0.01 on P-A, 0.54 {+-} 0.01 on lateral projections. These suggest hypoplasia of the pulmonary truck and anteriorly displaced conus septum and truncus septum from a developmental point of view. 4. The overriding degree of the aorta in our series are from 25% to 50% by Kjellberg et al classification.

  4. Primary Cardiac Synovial Sarcoma Originating From the Mitral Valve Causing Left Ventricular Outflow Tract Obstruction.

    Science.gov (United States)

    Prifti, Edvin; Veshti, Altin; Ikonomi, Majlinda; Demiraj, Aurel

    2015-10-01

    An 11-year-old boy was admitted with complaints of syncope and convulsion. Echocardiogram revealed a mass measuring 2 × 4 cm related to the mitral subvalvular apparatus. The mass, which appeared to be attached to the anterolateral papillary muscle, protruded into the left ventricular outflow tract causing intermittent obstruction. The patient underwent surgical excision of the mass. Pathology confirmed the diagnosis of primary synovial sarcoma. At six months following the operation, a small mass measuring 1 × 1 cm was detected in the left ventricle. The patient underwent reoperation consisting of radical resection of the subvalvular apparatus and mitral valve replacement. Histology confirmed that the mass was cardiac synovial sarcoma. One year after surgery, the patient is doing well. PMID:26467881

  5. Giant blood cyst tumor in the left ventricular outflow tract

    Institute of Scientific and Technical Information of China (English)

    ZHANG Chong; HU Jian; NI Yi-ming; JIANG Zhi-nong; XU He-yun

    2007-01-01

    @@ Blood cyst is a rare primary cardiac tumor usually affecting the cardiac valves. Associated with severe occlusion-related complications, it is generally removed surgically. With a brief review of the literature, we present a case of pedunculated tumor in the left ventricular outflow tract identified by echocardiography.

  6. Four-dimensional computed tomography: a method of assessing right ventricular outflow tract and pulmonary artery deformations throughout the cardiac cycle

    Energy Technology Data Exchange (ETDEWEB)

    Schievano, Silvia; Capelli, Claudio; Young, Carol; Lurz, Philipp; Nordmeyer, Johannes; Owens, Catherine; Bonhoeffer, Philipp; Taylor, Andrew M. [UCL, Institute of Child Health and Great, Ormond Street Hospital for Children, Cardiovascular Unit, London (United Kingdom)

    2011-01-15

    To characterise 3D deformations of the right ventricular outflow tract (RVOT)/ pulmonary arteries (PAs) during the cardiac cycle and estimate the errors of conventional 2D assessments. Contrast-enhanced, ECG-gated cardiovascular computed tomography (CT) findings were retrospectively analysed from 12 patients. The acquisition of 3D images over 10 phases of the cardiac cycle created a four-dimensional CT (4DCT) dataset. The datasets were reconstructed and deformation measured at various levels of the RVOT/PAs in both space and time. Section planes were either static or dynamic relative to the motion of the structures. 4DCT enabled measurement and characterisation of in vivo 3D changes of patients' RVOT/PA during the cardiac cycle. The studied patient population showed a wide range of RVOT/PA morphologies, sizes and dynamics that develop late after surgical repair of congenital heart disease. There were also significant differences in the measured cross-sectional areas of the structures between static and dynamic section planes (up to 150%, p < 0.05) secondary to large 3D displacements and rotations. 4DCT imaging data suggest high variability in RVOT/PA dynamics and significant errors in deformation measurements if 3D analysis is not carried out. These findings play an important role for the development of novel percutaneous approaches to pulmonary valve intervention. (orig.)

  7. The regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy patients with or without left ventricular outflow tract obstruction: Assessment with first-pass perfusion imaging using 3.0-T cardiac magnetic resonance

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    Xu, Hua-yan [Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041 (China); Yang, Zhi-gang, E-mail: yangzg666@163.com [Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041 (China); Sun, Jia-yu; Wen, Ling-yi; Zhang, Ge; Zhang, Shuai [Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041 (China); Guo, Ying-kun [Department of Radiology, West China Second University Hospital, Sichuan University (China)

    2014-04-15

    Purpose: To assess regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy (HCM) patients with or without left ventricular outflow tract obstruction using 3.0-T cardiac magnetic resonance (CMR) first-pass perfusion imaging. Materials and methods: Forty-two HCM patients, including 25 HCM patients with left ventricular outflow tract obstruction (HOCM), 17 HCM patients without left ventricular outflow tract obstruction (NOHCM), and 14 healthy subjects underwent CMR. The left ventricular (LV) function, left ventricular end-diastolic wall thickness (EDTH), and diameter of left ventricular outflow tract (LVOT) were measured and calculated. Based on the signal–time curve of the first-pass myocardium perfusion imaging, perfusion parameters including upslope, time to peak, and peak intensity, were assessed and compared by using one-way analysis of variance and independent t tests. Results: On the first-pass perfusion imaging, lower upslope and peak intensity and longer time to peak were found in HCM patients compared with normal subjects (all p < 0.05). In contrast to the NOHCM group, the average time to peak of the HOCM group was increased (13.30 ± 4.82 s vs 16.28 ± 4.90 s, p < 0.05), but first-pass perfusion upslope was reduced (4.96 ± 2.55 vs 2.58 ± 0.77, p < 0.05). According to the bull's-eye model, the HOCM group's average thickness of basal segments was thicker than the NOHCM group, especially the anteroseptal, inferolateral, and anterior wall values, with a corresponding lower first-pass perfusion upslope than the NOHCM group (all p < 0.05). A significant correlation was observed between first-pass perfusion upslope and LV EDTH (r = −0.551, p < 0.001) and LVOT diameter (r = 0.472, p < 0.001). Conclusions: The regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy (HCM) patients with or without left ventricular outflow tract obstruction can be detected with first-pass perfusion CMR

  8. Fibulin-1 suppresses endothelial to mesenchymal transition in the proximal outflow tract

    DEFF Research Database (Denmark)

    Harikrishnan, K.; Cooley, M. A.; Sugi, Y.; Barth, J. L.; Rasmussen, L. M.; Kern, C. B.; Argraves, K. M.; Argraves, W. S.

    2015-01-01

    Endothelial to mesenchymal transition (EMT) that occurs during cardiac outflow tract (OFT) development is critical for formation of the semilunar valves. Fibulin-1 (Fbln1) is an extracellular matrix protein that is present at several sites of EMT, including the OFT (i.e., E9.5-10.5). The aim of t...

  9. Right ventricular myxoma obstructing the right ventricular outflow tract: a case report

    OpenAIRE

    Gribaa, Rym; Slim, Mehdi; Kortas, Chokri; Kacem, Slim; Salem, Helmi Ben; Ouali, Sana; Neffati, Elies; Remadi, Fehmi; Boughzela, Essia

    2014-01-01

    Introduction Primary cardiac tumors are uncommon during infancy and childhood. Myxomas originating from the right ventricle are even less common in pediatric patients. Case presentation Here we describe a case of an 11-year-old Tunisian boy who was referred for syncope. Transthoracic echocardiography revealed a large mobile mass attached to his right ventricle, obstructing his right ventricular outflow tract. Complete surgical excision of the mass with preservation of the pulmonary valve was ...

  10. Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling.

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    Rui Zhang

    Full Text Available Glycosaminoglycans are important regulators of multiple signaling pathways. As a major constituent of the heart extracellular matrix, glycosaminoglycans are implicated in cardiac morphogenesis through interactions with different signaling morphogens. Ext1 is a glycosyltransferase responsible for heparan sulfate synthesis. Here, we evaluate the function of Ext1 in heart development by analyzing Ext1 hypomorphic mutant and conditional knockout mice. Outflow tract alignment is sensitive to the dosage of Ext1. Deletion of Ext1 in the mesoderm induces a cardiac phenotype similar to that of a mutant with conditional deletion of UDP-glucose dehydrogenase, a key enzyme responsible for synthesis of all glycosaminoglycans. The outflow tract defect in conditional Ext1 knockout(Ext1f/f:Mesp1Cre mice is attributable to the reduced contribution of second heart field and neural crest cells. Ext1 deletion leads to downregulation of FGF signaling in the pharyngeal mesoderm. Exogenous FGF8 ameliorates the defects in the outflow tract and pharyngeal explants. In addition, Ext1 expression in second heart field and neural crest cells is required for outflow tract remodeling. Our results collectively indicate that Ext1 is crucial for outflow tract formation in distinct progenitor cells, and heparan sulfate modulates FGF signaling during early heart development.

  11. The role of local voltage potentials in outflow tract ectopy

    DEFF Research Database (Denmark)

    Thomsen, P.E.B.; Johannessen, A.; Jons, C.;

    2010-01-01

    Discrete, fragmented, local voltage potentials (LVPs) have been observed in electrograms recorded at the ablation site in patients undergoing radiofrequency ablation for arrhythmias originating in both the right and left ventricular outflow tract; however, the incidence and the significance of the...... LVP with respect to arrhythmogenesis is uncertain. We studied 25 patients with outflow tract arrhythmias referred for radiofrequency catheter ablation and recorded high-amplified intracardiac electrograms close to the site of origin of the arrhythmia. Ten patients undergoing ablation for...... ventricular premature beats. In 10 patients, ventricular parasystole was suggested by varying coupling intervals > 100 ms, and fusion beats allowing for the estimation of the least common denominator of R-R intervals. In 23 of the 25 patients, the 12-lead electrocardiogram (ECG) and intracardiac contact...

  12. Downregulation of Rho associated coiled-coil forming protein kinase 1 in the process of delayed myocardialization of cardiac proximal outflow tract septum in connexin 43 knockout mice embryo

    Institute of Scientific and Technical Information of China (English)

    QI Chun-hua; ZHAO Xiao-qing; MA Duan; MA Xiao-jing; ZHOU Guo-min; HUANG Guo-ying

    2011-01-01

    Background The connexln43 knockout (Cx43 KO) mouse dies at birth with an enlarged conotruncal region, which leads to the obstruction of the right outflow tract (OFT). Since myocardialization of the proximal OFT septum is one of the key events during heart development, we investigated the process in the Cx43 KO embryo hearts. Rho associated coiled-coil forming protein kinase 1 (ROCK1), is a recently found key molecule to regulate the myocardialization of OFT, but its spatiotemporal expression pattern during myocardialization remains unknown. The objective of this study was to investigate the differentially expressed pattern of ROCK1 between Cx43 KO and wild type embryo hearts, and its relationship with the delayed myocardialization in Cx43 KO embryo hearts.Methods Using immunohistochemistry, the processes of myocardiolization were investigated both in Cx43 KO and wild type embryo hearts. The differentially expressed pattern of ROCK1 between Cx43 KO and wildtype embryo hearts was evaluated both at the mRNA and protein level by real-time RT-PCR and immunohistochemistry.Results The expression of α-sarcomeric actin (α-SCA) in the proximal OFT septum of Cx43 KO embryos was delayed. Meanwhile, it was shown that the downregulation of ROCK1 coincided with delayed myocardialization. The expression of ROCK1 protein was mainly limited to the proximal outflow tract septum from embryo day (E) E11.5 to E15.5. Its expression pattern was similar with that of α-SCA. Real-time RT-PCR found that the expression level of Rock-1 mRNA began at a low level on E11.5 and reached peak at E13.5 and E14.5.Conclusions ROCK1 may have an important role in the process of myocardialization of the proximal OFT septum. Downregulation of ROCK1 is likely to contribute to the aberrant myocardialization in Cx43 KO embryo hearts.

  13. Right ventricular outflow tract arrhythmias: benign or early stage arrhythmogenic right ventricular cardiomyopathy/dysplasia?

    Directory of Open Access Journals (Sweden)

    Sergio Conti, MD; Laura Cipolletta, MD; Vittoria Marino, MD; Martina Zucchetti, MD; Eleonora Russo, MD; Francesca Pizzamiglio, MD; Ghaliah Al-Mohani, MD; Salvatore Pala, BE; Valentina Catto, BE, PhD; Luigi Di Biase, MD, PhD; Andrea Natale, MD; Claudio Tondo, MD, PhD; Corrado Carbucicchio, MD

    2014-12-01

    Full Text Available Ventricular arrhythmias (VAs arising from the right ventricular outflow tract (RVOT are a common and heterogeneous entity. Idiopathic right ventricular arrhythmias (IdioVAs are generally benign, with excellent ablation outcomes and long-term arrhythmia-free survival, and must be distinguished from other conditions associated with VAs arising from the right ventricle: the differential diagnosis with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D is therefore crucial because VAs are one of the most important causes of sudden cardiac death (SCD in young individuals even with early stage of the disease. Radiofrequency catheter ablation (RFCA is a current option for the treatment of VAs but important differences must be considered in terms of indication, purposes and procedural strategies in the treatment of the two conditions. In this review, we comprehensively discuss clinical and electrophysiological features, diagnostic and therapeutic techniques in a compared analysis of these two entities.

  14. Septation and shortening of outflow tract in embryonic mouse heart involve changes in cardiomyocyte phenotype and α-SMA positive cells in the endocardium

    Institute of Scientific and Technical Information of China (English)

    杨艳萍; 李海荣; 景雅

    2004-01-01

    Background Studies on human, rat and chicken embryos have demonstrated that during the period of outflow tract septation, retraction of the distal myocardial margin of the outflow tract from the junction with aortic sac to the level of semilunar valves leads to the shortening of the myocardial tract. However, the mechanism is not clear. So we investigated the mechanism of outflow tract shortening and remodeling and the spatio-temporal distribution pattern of α-SMA positive cells in the outflow tract cushion during septation of the outflow tract in the embryonic mouse heart. Methods Serial sections of mouse embryos from embryonic day 9 (ED 9) to embryonic day 16 (ED 16) were stained with monoclonal antibodies against α-SCA, α-SMA, or desmin, while apoptosis was assessed using the terminal deoxyribonucleotidy transferase-mediated dUTP-digoxigenin nick-end labeling (TUNEL) assay. Results Between ED 11 and ED 12, the cardiomyocytes in the distal portion of the outflow tract were observed losing their myocardial phenotype without going into apoptosis, suggesting that trans-differentiation of cardiomyocytes into the cell components of the free walls of the intrapericardial ascending aorta and pulmonary trunk. The accumulation of α-SMA positive cells in the cardiac jelly began on ED 10 and participated in the ridge fusion and septation of the outflow tract. Fusion of the distal ridges resulted in the formation of the facing walls of the intrapericardial ascending aorta and pulmonary trunk. Fusion of the proximal ridges was accompanied by the accumulation of α-SMA positive cells into a characteristic central whorl, in which cell apoptosis could be observed. Subsequent myocardialization resulted in the formation of the partition between the subaortic and subpulmonary vestibules. Conclusions The shortening of the embryonic heart outflow tract in mice may result not from apoptosis, but from the trans-differentiation of cells with cardiomyocyte phenotype in the distal

  15. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis.

    Science.gov (United States)

    Beppu, Hideyuki; Malhotra, Rajeev; Beppu, Yuko; Lepore, John J; Parmacek, Michael S; Bloch, Kenneth D

    2009-07-15

    Signaling of bone morphogenetic protein (BMP) via type I and type II receptors is involved in multiple processes contributing to cardiogenesis. To investigate the role of the BMP type II receptor (BMPRII) in heart development, the BMPRII gene was deleted throughout the embryo during gastrulation using a Mox2-Cre transgene. BMPRII(flox/-);Mox2-Cre mice exhibited cardiac defects including double-outlet right ventricle, ventricular septal defect (VSD), atrioventricular (AV) cushion defects, and thickened valve leaflets. To characterize the tissue-specific functions of BMPRII in cardiogenesis, a series of Cre transgenes (alphaMHC-, Tie2-, Wnt1-, and SM22alpha-Cre) was employed. Interestingly, myocardial development was normal when the BMPRII gene was deleted in myocardial cells using Mox2-Cre, alphaMHC-Cre, or SM22alpha-Cre transgenes, suggesting that signaling by other BMP type II receptors may compensate for the absence of BMPRII in the myocardial cells. AV cushion defects including atrial septal defect, membranous VSD, and thickened valve leaflets were found in BMPRII(flox/-);Tie2-Cre mice. Abnormal positioning of the aorta was observed in BMPRII(flox/-);Wnt1-Cre and BMPRII(flox/-);SM22alpha-Cre mice. Taken together, these results demonstrate that endocardial BMPRII expression is required for septal formation and valvulogenesis. Moreover, mesenchymal BMPRII expression in the outflow tract cushion is required for proper positioning of the aorta. PMID:19409885

  16. Human sinus arrhythmia as an index of vagal cardiac outflow

    Science.gov (United States)

    Eckberg, D. L.

    1983-01-01

    The human central vagal mechanisms were investigated by measuring the intervals between heartbeats during controlled breathing (at breathing intervals of 2.5-10 s and nominal tidal volumes of 1000 and 1500 ml) in six young men and women. It was found that as the breathing interval increased, the longest heart periods became longer, the shortest heart periods became shorter, and the peak-valley P-P intervals increased asymptotically. Peak-valley intervals also increased in proportion to tidal volume, although this influence was small. The phase angles between heart period changes and respiration were found to vary as linear functions of breathing interval. Heart period shortening began in inspiration at short breathing intervals and in expiration at long breathing intervals, while heart period lengthening began in early expiration at all breathing intervals studied. It is concluded that a close relationship exists between variations of respiratory depth and interval and the quantity, periodicity, and timing of vagal cardiac outflow in conscious humans. The results indicate that at usual breathing rates, phasic respiration-related changes of vagal motoneuron activity begin in expiration, progress slowly, and are incompletely expressed at fast breathing ratges.

  17. Changes in wall motion and blood flow in the outflow tract of chick embryonic hearts observed with optical coherence tomography after outflow tract banding and vitelline-vein ligation

    International Nuclear Information System (INIS)

    Optical coherence tomography (OCT) is a non-contact, non-invasive and high-resolution imaging technique, suited to study early cardiovascular development. Alterations in hemodynamic conditions during early development are known to lead to cardiac defects, presumably as a result of changes in cardiac biomechanics produced by the alterations. In this paper, we demonstrate the use of a spectral domain OCT in visualizing and quantifying changes in cardiac wall motion and blood-flow velocities under normal and altered hemodynamic conditions in chicken embryos at an early stage of development (Hamburger-Hamilton stage HH18, ∼3 days of incubation), focusing on the heart outflow tract (OFT). The OCT system employed acquired simultaneously microstructural and blood-flow images at a rate of 92 frames s-1with a spatial resolution of ∼10 μm. OCT imaging allowed in vivo visualization of the OFT microstructures, e.g. the lumen, cardiac cushions and myocardium. We found that alterations in hemodynamic conditions, through OFT banding and vitelline-vein ligation, changed blood-flow velocities through the OFT, as expected. Further, OCT allowed quantification of changes in the dynamics of OFT wall motion. Our results therefore establish the utility of spectral domain OCT to study the influence of hemodynamic conditions on heart development in intact, in vivo chicken embryo models

  18. The role of hemodynamics in the development of the outflow tract of the heart

    NARCIS (Netherlands)

    Loots, Erwin; Hillen, Berend; Veldman, Arthur E.P.

    2003-01-01

    The question whether, and if so to what extent, hemodynamic forces and mechanical stimuli do modulate the morphogenesis of the vascular system is a century-old problem. It is important especially in the outflow tract where a spiraling septum develops in and after a strong bend in the tube. Spiraling

  19. Blood flowing state analysis in outflow tract of chick embryonic heart based on spectral domain optical coherence tomography

    Science.gov (United States)

    Zhao, Yuqian; Suo, Yanyan; Liang, Chengbo; Ma, Zhenhe

    2016-03-01

    The cardiac development is a complicated process affected by genetic and environmental factors. Wall shear stress (WSS) and periodic stress (WPS) are the components which have been proved to influence the morphogenesis during early stages of cardiac development. The vessel wall will be deformed by the blood pressure and produce natural elastic force acting on the blood. Because blood flowing in different flow state and show different characteristics of fluid, which influence the calculation of WSS and WPS directly, it is necessary to study the blood flow state. In this paper, we introduce a method to quantify the blood flowing state of early stage chick embryonic heart based on high speed spectral domain optical coherence tomography (SDOCT).4D (x,y,z,t) scan was performed on the outflow tract (OFT) of HH18 (~3 days of incubation) chick embryonic heart. By processing the structural image, the geometric parameters were obtained. Blood flow velocity distribution in the OFT were calculated by Doppler OCT method. Hemodynamic parameters were obtained at different times during the cardiac cycle used biofluid mechanics theory, such as Reynolds number and Womersley number.

  20. A case of biventricular endomyocardial fibrosis complicated by right ventricular outflow tract aneurysms.

    Science.gov (United States)

    Gonçalves, Ricardo; Meel, Ruchika

    2016-01-01

    Endomyocardial fibrosis remains a major public health problem worldwide. It is a restrictive cardiomyopathy, of uncertain aetiology, which may lead to right, left or biventricular heart failure. Progress continues to be made in understanding the prevalence and natural history of this disease. Specific treatment, apart from surgery, remains suboptimal. We report a case of advanced, biventricular EMF complicated by right ventricular outflow tract aneurysms. PMID:27245722

  1. Left ventricular outflow tract false aneurysm late after aortic valve replacement.

    Science.gov (United States)

    Bizzarri, Federico; Braconi, Lucio; Rossi, Alessandra; Sorbara, Carlo; Stefano, Pier Luigi

    2005-01-01

    We describe an unusual case of left ventricular outflow tract (LVOT) pseudoaneurysm late after aortic valve replacement. A 77-year-old man, who had undergone aortic valve replacement with mechanical prosthesis 7 years ago, presented, asymptomatic, with a transesophageal echocardiography (TTE) diagnosis of a large cavitary mass arising behind the aortic wall. The orifice of the pseudoaneurysm was successfully surgically closed and the aortic root reconstructed with cryopreserved homograft. PMID:15870043

  2. Blood Flow Simulations for the Design of Stented Valve Reducer in Enlarged Ventricular Outflow Tracts

    OpenAIRE

    Caiazzo, Alfonso; Guibert, Romain; Boudjemline, Younes; Vignon-Clementel, Irene

    2015-01-01

    International audience Tetralogy of Fallot is a congenital heart disease characterized over time, after the initial repair, by the absence of a functioning pulmonary valve, which causes regurgitation, and by progressive enlargement of the right ventricle outflow tract (RVOT). Due to this pathological anatomy, available transcatheter valves are usually too small to be deployed there. To avoid surgical valve replacement, an alternative consists in implanting a reducer prior to or in combinat...

  3. Right ventricular outflow tract arrhythmias: benign or early stage arrhythmogenic right ventricular cardiomyopathy/dysplasia?

    OpenAIRE

    Sergio Conti, MD; Laura Cipolletta, MD; Vittoria Marino, MD; Martina Zucchetti, MD; Eleonora Russo, MD; Francesca Pizzamiglio, MD; Ghaliah Al-Mohani, MD; Salvatore Pala, BE; Valentina Catto, BE, PhD; Luigi Di Biase, MD, PhD; Andrea Natale, MD; Claudio Tondo, MD, PhD; Corrado Carbucicchio, MD

    2014-01-01

    Ventricular arrhythmias (VAs) arising from the right ventricular outflow tract (RVOT) are a common and heterogeneous entity. Idiopathic right ventricular arrhythmias (IdioVAs) are generally benign, with excellent ablation outcomes and long-term arrhythmia-free survival, and must be distinguished from other conditions associated with VAs arising from the right ventricle: the differential diagnosis with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is therefore crucial beca...

  4. Dynamic left ventricular outflow tract obstruction complicating aortic valve replacement: A hidden malefactor revisited

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    Panduranga Prashanth

    2010-01-01

    Full Text Available It is known that a dynamic left ventricular outflow tract (LVOT obstruction exists in patients, following aortic valve replacement (AVR and is usually considered to be benign. We present a patient with dynamic LVOT obstruction following AVR, who developed refractory cardiogenic shock and expired inspite of various treatment strategies. This phenomenon must be diagnosed early and should be considered as a serious and potentially fatal complication following AVR. The possible mechanisms and treatment options are reviewed.

  5. Transcatheter Pulmonary Valve Replacement for Right Ventricular Outflow Tract Conduit Dysfunction After the Ross Procedure

    DEFF Research Database (Denmark)

    Gillespie, Matthew J; McElhinney, Doff B; Kreutzer, Jacqueline; Hellenbrand, William E; El-Said, Howaida; Ewert, Peter; Rhodes, John F; Søndergaard, Lars; Jones, Thomas K

    2015-01-01

    BACKGROUND: Right ventricular outflow tract (RVOT) conduit dysfunction is a limitation of the Ross procedure. Transcatheter pulmonary valve replacement (TPVR) could alter the impact of conduit dysfunction and the risk-benefit balance for the Ross procedure. METHODS: Retrospective review of...... databases from 3 prospective Melody TPV (Medtronic Inc, Minneapolis, MN) trials. RESULTS: Among 358 patients who were catheterized with the intent to implant a Melody TPV for RVOT conduit stenosis or regurgitation (PR) as part of 3 prospective multicenter studies, 67 (19%) had a prior Ross procedure. Of...

  6. Rate of Cure of Right Ventricular Outflow Tract Tachycardia: A Review Paper

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    Dr. Abdel Fuenmayor

    2014-06-01

    Full Text Available Right ventricular outflow tract (RVOT ventricular tachycardias (VT occur in the absence of structural heart disease and are called idiopathic ventricular arrhythmias. These arrhythmias are thought to be produced by adenosine-sensitive, cyclic AMP mediated, triggered activity and are commonly observed in adolescents and young adults. In the ECG, they appear with a wide QRS complex, a left bundle branch block morphology and, usually, an inferior QRS axis. In the last few years, there has been an increasing number of reports suggesting the possibility of a curative treatment of RVOT VT by means of catheter ablation. This paper reviews the rate of cure of such arrhythmias by discussing the effects of catheter ablation on symptoms, arrhythmia detection, possibility of induction, and short- and long-term follow-up studies.

  7. Prevalence of exercise-induced left ventricular outflow tract obstruction in symptomatic patients with non-obstructive hypertrophic cardiomyopathy.

    LENUS (Irish Health Repository)

    Shah, J S

    2008-10-01

    Resting left ventricular outflow tract obstruction (LVOTO) occurs in 25% of patients with hypertrophic cardiomyopathy (HCM) and is an important cause of symptoms and disease progression. The prevalence and clinical significance of exercise induced LVOTO in patients with symptomatic non-obstructive HCM is uncertain.

  8. A rare combination of undiagnosed hypertrophic cardiomyopathy revealed by intraoperative anaphylaxis resulting in acute left ventricular outflow obstruction and cardiac arrest.

    Science.gov (United States)

    Smith, Bradford B; Nickels, Andrew S; Sviggum, Hans P

    2016-06-01

    A 75-year-old female presented for left total hip reimplantation and suffered pulseless electrical activity arrest upon lateral positioning and administering vancomycin. Resuscitation was achieved according to Advanced Cardiac Life Support protocol. Post-event echocardiography showed hypertrophic cardiomyopathy with asymmetrical septal thickening, an under-filled left ventricle, dynamic left ventricular outflow obstruction, and severe mitral regurgitation related to systolic anterior motion of the mitral valve. Laboratory analysis showed a tryptase level of 209 ng/mL. After multispecialty evaluation, it was concluded that the patient's arrest was due to vancomycin anaphylaxis in the setting of previously undiagnosed hypertrophic cardiomyopathy leading to acute left ventricular outflow tract obstruction. After medical optimization of the patient's cardiomyopathy and an evaluation of potential intraoperative allergic triggers, the patient underwent a successful hip reimplantation without incident. This case presents a novel combination of events leading to intraoperative cardiac arrest. Rapid identification and an understanding of the cause(s) of cardiac arrest in this setting are critical for effective perioperative care. PMID:27185714

  9. Effect of Left Ventricular Outflow Tract Obstruction on Left Atrial Mechanics in Hypertrophic Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Lynne K. Williams

    2015-01-01

    Full Text Available Left atrial (LA volumes are known to be increased in hypertrophic cardiomyopathy (HCM and are a predictor of adverse outcome. In addition, LA function is impaired and is presumed to be due to left ventricular (LV diastolic dysfunction as a result of hypertrophy and myocardial fibrosis. In the current study, we assess the incremental effect of outflow tract obstruction (and concomitant mitral regurgitation on LA function as assessed by LA strain. Patients with HCM (50 obstructive, 50 nonobstructive were compared to 50 normal controls. A subset of obstructive patients who had undergone septal myectomy was also studied. Utilising feature-tracking software applied to cardiovascular magnetic resonance images, LA volumes and functional parameters were calculated. LA volumes were significantly elevated and LA ejection fraction and strain were significantly reduced in patients with HCM compared with controls and were significantly more affected in patients with obstruction. LA volumes and function were significantly improved after septal myectomy. LVOT obstruction and mitral regurgitation appear to further impair LA mechanics. Septal myectomy results in a significant reduction in LA volumes, paralleled by an improvement in function.

  10. Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects

    Directory of Open Access Journals (Sweden)

    Sucov Henry M

    2006-11-01

    Full Text Available Abstract Background Congenital cardiovascular diseases are the most common form of birth defects in humans. A substantial portion of these defects has been associated with inappropriate induction, migration, differentiation and patterning of pluripotent cardiac neural crest stem cells. While TGF-β-superfamily signaling has been strongly implicated in neural crest cell development, the detailed molecular signaling mechanisms in vivo are still poorly understood. Results We deleted the TGF-β type I receptor Alk5 specifically in the mouse neural crest cell lineage. Failure in signaling via ALK5 leads to severe cardiovascular and pharyngeal defects, including inappropriate remodeling of pharyngeal arch arteries, abnormal aortic sac development, failure in pharyngeal organ migration and persistent truncus arteriosus. While ALK5 is not required for neural crest cell migration, our results demonstrate that it plays an important role in the survival of post-migratory cardiac neural crest cells. Conclusion Our results demonstrate that ALK5-mediated signaling in neural crest cells plays an essential cell-autonomous role in the pharyngeal and cardiac outflow tract development.

  11. Left ventricular outflow tract obstruction due to anomalous mitral valve: successful mitral valve replacement in a four month old infant.

    OpenAIRE

    Morais, P.; Westaby, S.; Hallidie-Smith, K A

    1986-01-01

    A four month old infant was investigated for heart failure was found to have mitral incompetence and severe subvalvar aortic stenosis. The left ventricular outflow tract obstruction was found to be due to an anatomically anomalous mitral valve. The obstruction could only be relieved by removal of the mitral valve and its replacement with a St Jude's prosthesis. Two years after operation the child is fit and active. There have been no difficulties with anticoagulant treatment.

  12. Cardiogenic shock accompanied by dynamic left ventricular outflow tract obstruction and myocardial bridging after transient complete atrioventricular block mimicking ST-elevation myocardial infarction: a case report

    OpenAIRE

    Kang, Seonghui; An, Sanghee; Yu, Hyung Min; Kim, Jiwan; Kim, Sung Hea; Kim, Hyun-Joong; Chung, Sang Man

    2013-01-01

    Background Dynamic left ventricular outflow tract obstruction with or without mitral regurgitation is typically observed in hypertrophic cardiomyopathy, but is also occasionally seen without left ventricular hypertrophy. In this report, we present a case of cardiogenic shock that mimics ST-elevation myocardial infarction, due to dynamic left ventricular outflow tract obstruction with transient mitral regurgitation and myocardial bridging after transient complete atrioventricular block. Case p...

  13. Pulmonary endoderm, second heart field and the morphogenesis of distal outflow tract in mouse embryonic heart

    Institute of Scientific and Technical Information of China (English)

    SHI Liang; JING Ya; LI Huichao; WANG Yunxiu; WU Shanshan; CAI Yujin; CUI Huilin; YANG Yanping

    2015-01-01

    Objective:The second heart field ( SHF) , foregut endoderm and sonic hedgehog ( SHH) signa-ling pathway are associate with normal morphogenesis and septation of outflow tract ( OFT) . However, the morpho-logical relationships of the development of foregut endoderm and expression of SHH signaling pathway members with the development of surrounding SHF and OFT are seldom described. In this study, serial sections of mouse embryos from ED9 to ED13 ( midgestation) were stained with a series of marker antibodies for specifically highlighting SHF ( Isl-1 ) , endoderm ( Foxa2 ) , basement membrane ( Laminin ) , myocardium ( MHC ) and smooth muscle (α-SMA) respectively, or SHH receptors antibodies including patched1 (Ptc1), patched2 (Ptc2) and smoothened, to observe the spatiotemporal relationship between them and their contributions to OFT morphogenesis. Results: Our results demonstrated that the development of an Isl-1 positive field in the splanchnic mesoderm ventral to foregut, a subset of SHF, was closely coupled with pulmonary endoderm or tracheal groove, the Isl-1 positive cells sur-rounding pulmonary endoderm were distributed in a special cone-shaped pattern and contributed to the formation of the lateral walls of the intrapericardial aorta and pulmonary trunk and the transient aortic-pulmonary septum, and Ptc1 and Ptc2 were exclusively expressed in pulmonary endoderm during this Isl-l positive field development, suggesting special roles played in inducing the Isl-l positive field formation by pulmonary endoderm. Conclusions: Pulmonary endoderm plays a role in the development and specification of SHF in midgestation, and that pulmonary endoderm-associated Isl-l positive field is involved in patterning the morphogenesis and septation of the intrapericardial arterial trunks.

  14. Blood Flow Simulations for the Design of Stented Valve Reducer in Enlarged Ventricular Outflow Tracts.

    Science.gov (United States)

    Caiazzo, Alfonso; Guibert, Romain; Boudjemline, Younes; Vignon-Clementel, Irene E

    2015-12-01

    Tetralogy of Fallot is a congenital heart disease characterized over time, after the initial repair, by the absence of a functioning pulmonary valve, which causes regurgitation, and by progressive enlargement of the right ventricle outflow tract (RVOT). Due to this pathological anatomy, available transcatheter valves are usually too small to be deployed there. To avoid surgical valve replacement, an alternative consists in implanting a reducer prior to or in combination with the valve. It has been shown in animal experiments to be promising, but with some limitations. The effect of a percutaneous pulmonary valve reducer on hemodynamics in enlarged RVOT is thus studied by computational modeling. To this aim, blood flow in the RVOT is modeled with CFD coupled to a simplified valve model and 0D downstream models. Simulations are performed in an image-based geometry and boundary conditions tuned to reproduce the pathological flow without the device. Different device designs are built and compared with the initial device-free state, or with the reducer alone. Results suggest that pressure loss is higher for the reducer alone than for the full device, and that the latter successfully restores hemodynamics to a healthy state and induces a more symmetric flow in the pulmonary arteries. Moreover, pressure forces on the reducer and on the valve have the same magnitudes. Migration would occur towards the right ventricle rather than the pulmonary arteries. Results support the thesis that the reducer does not introduce clinically significant pressure gradients, as was found in animal experiments. Such study could help transfer to patients. PMID:26577481

  15. Patients' and physicians' needs, experiences and preferences in the treatment of right ventricular outflow tract dysfunction

    Directory of Open Access Journals (Sweden)

    Luciana Scalone

    2012-06-01

    Full Text Available

    Background: patients with congenital heart defects, developing right ventricular outflow tract (rVoT dysfunction, can face repeated open chest interventions over their lifetime. repeating surgery increases difficulties and procedural risks, and exposes patients to burdensome and long recovery times that may induce them to postpone the treatment, with possible severe and irreversible consequences for their health. The percutaneous procedure was introduced to delay the need for open chest surgery. uncertainties still exist regarding the lifelong consequences that may result from adopting different treatment strategies. current decisions on treatment depend on patients’ clinical needs, but also on physicians’ experience and opinion, patients’ preferences, and procedural costs. The objective is to identify which treatment characteristics influence decisions on how to treat patients with rVoT dysfunction.

    Methods: a literature review was conducted, followed by a discussion with a panel of experts. Ten treatment characteristics, potentially relevant for treatment, were identified and rated in a survey, according to the importance assigned to each characteristic by specialist physicians, patients and/or their caregivers.

    Results: while some characteristics appear to be more important (risk of severe complications associated with intervention delays or less important (scar to both physicians and patients/caregivers, other characteristics are rated differently in importance depending on subjects consulted, e.g., risk of complications during the months post intervention was among the most important characteristics for patients/caregivers, but the fifth most important characteristic for physicians.

    Conclusions: to optimize benefits and efficiency of the treatment strategies, perceptions and opinions from the different subjects involved, together with patients

  16. Quantification of avian embryonic cardiac outflow hemodynamics through 3D-0D coupling

    Science.gov (United States)

    Lindsey, Stephanie; Vignon-Clementel, Irene; Butcher, Jonathan

    2014-11-01

    Outflow malformations account for over 20% of CHDs in the US. While the etiology of these malformations is poorly understood, most can be traced back to perturbations in the patterning of the pharyngeal arch arteries (PAAs), the precursors to the great vessels. Here, we examine the effects of normal and aberrant PAA flow, through the use of two computational models. A 0D electric analog model allows for rapid computation and global tuning of the embryo's vasculature relative to the arches. A second 3D-0D model replaces the electric analog representation of the arches with a 3D reconstruction, thereby leading to more extensive pressure and flow characterization. We obtain 3D arch artery reconstructions from nano-CT stacks and couple them to 0D outlets. In contrast to standard boundary conditions, such coupling maintains the physiologically desired cranial-caudal flow split in control embryos and predicts how this will change with vessel occlusion. We use flow inputs from Doppler velocity tracings to compute 0D and 3D-0D pulsatile hemodynamic simulations in HH18 (day 3), HH24 (day 4), and HH26 (day 5) geometries. We then calculate flow distributions and wall shear stress maps for control embryos. From here, we modify HH18 geometries to simulate varying levels of PAA occlusion. Pulsatile simulations are run in each geometry and results compared to that of controls. Results serve as a basis for examining flow-mediated growth and adaptation in cardiac outflow morphogenesis.

  17. Decreased expression of neurotrophic tyrosine receptor kinase 3 is associated with the outflow tract defect of human tetralogy of Fallot

    Institute of Scientific and Technical Information of China (English)

    KONG Bo; LIU Ying-long; L(U) Xiao-dong

    2009-01-01

    Background The molecular mechanism of human tetralogy of Fallot (TOF) is incompletely defined. Animal models have suggested that neurotrophic tyrosine receptor kinase 3 (NTRK3) might be associated with the outflow tract defect, similar to that seen in human TOF, however, the expression pattern of NTRK3 in human TOF heart tissues has never been investigated. Methods Quantitative real-time PCR (qRT-PCR) and immunohistochemistry were applied to detect NTRK3 mRNA and protein levels in right ventricular outflow tract tissue samples of TOF patients, ventricular septal defect (VSD) patients and normal control infants (n=10 in each group). Results qRT-PCR analysis indicated that NTRK3 mRNA levels were significantly decreased in the TOF group compared to the VSD group (0.024±0.003 vs 0.085±0.004, P=0.022) and the normal control group (0.024±0.003 vs 0.091±0.002, P=0.006). Quantitative immunohistochemical analysis showed that NTRK3 protein was mainly localized in the myocardium cytoplasm in all 3 groups. The immunoreactivity of NTRK3 protein was again significantly lower in the TOF group compared to the VSD group (1.42±0.62 vs 14.12±1.83, P=0.023) and the control group (1.42±0.62 VS 16.25±2.31, P=0.008). The expression of NTRK3 in the VSD group and in the control group showed no significant differences at both mRNA and protein levels. Conclusions Insufficient expression of NTRK3 is associated with the outflow tract defect of human tetralogy of Fallot and may contribute to the progression of this defect.

  18. Dynamic left ventricular outflow tract obstruction secondary to hypovolemia in a German Shepard dog with splenic hemangiosarcoma

    OpenAIRE

    AOKI, Takuma; Sunahara, Hiroshi; Sugimoto, Keisuke; ITO, Tetsuro; KANAI, Eiichi; NEO, Sakurako; FUJII, Yoko; WAKAO, Yoshito

    2015-01-01

    Dynamic left ventricular outflow tract obstruction (DLVOTO) is a common condition in cats and humans. In this case report, a dog is described with DLVOTO secondary to severe intra-abdominal hemorrhage caused by a hemangiosarcoma. The dog was a 9-year-old, 35.7-kg, spayed female German Shepard dog that presented with a history of tachypnea and collapse. A Levine II/VI systolic murmur was present at the heart base. Abdominal ultrasonography revealed a splenic mass and a large amount of ascites....

  19. Dynamic left ventricular outflow tract obstruction secondary to hypovolemia in a German Shepard dog with splenic hemangiosarcoma.

    Science.gov (United States)

    Aoki, Takuma; Sunahara, Hiroshi; Sugimoto, Keisuke; Ito, Tetsuro; Kanai, Eiichi; Neo, Sakurako; Fujii, Yoko; Wakao, Yoshito

    2015-09-01

    Dynamic left ventricular outflow tract obstruction (DLVOTO) is a common condition in cats and humans. In this case report, a dog is described with DLVOTO secondary to severe intra-abdominal hemorrhage caused by a hemangiosarcoma. The dog was a 9-year-old, 35.7-kg, spayed female German Shepard dog that presented with a history of tachypnea and collapse. A Levine II/VI systolic murmur was present at the heart base. Abdominal ultrasonography revealed a splenic mass and a large amount of ascites. Echocardiography showed a reduced left ventricular diameter and an increased aortic velocity caused by systolic anterior motion (SAM) of the mitral valve apparatus. The heart murmur and the SAM were resolved after treatment including a splenectomy and a blood transfusion. PMID:25924797

  20. A reduced-order modeling for efficient design study of artificial valve in enlarged ventricular outflow tracts.

    Science.gov (United States)

    Caiazzo, A; Guibert, R; Vignon-Clementel, I E

    2016-09-01

    A computational approach is proposed for efficient design study of a reducer stent to be percutaneously implanted in enlarged right ventricular outflow tracts (RVOT). The need for such a device is driven by the absence of bovine or artificial valves which could be implanted in these RVOT to replace the absent or incompetent native valve, as is often the case over time after Tetralogy of Fallot repair. Hemodynamics are simulated in the stented RVOT via a reduce order model based on proper orthogonal decomposition, while the artificial valve is modeled as a thin resistive surface. The reduced order model is obtained from the numerical solution on a reference device configuration, then varying the geometrical parameters (diameter) for design purposes. To validate the approach, forces exerted on the valve and on the reducer are monitored, varying with geometrical parameters, and compared with the results of full CFD simulations. Such an approach could also be useful for uncertainty quantification. PMID:26738807

  1. Pacing the right ventricular outflow tract septum: time to embrace the future.

    Science.gov (United States)

    Hillock, Richard J; Mond, Harry G

    2012-01-01

    Transvenous pacing has revolutionized the management of patients with potentially life-threatening bradycardias and at its most basic level ensures rate support to maintain cardiac output. However, we have known for at least a decade that pacing from the right ventricle (RV) apex can induce left ventricle (LV) dysfunction, atrial fibrillation, heart failure, and maybe an increased mortality. Although pacemaker manufacturers have developed successful pacing algorithms designed to minimize unnecessary ventricular pacing, it cannot be avoided in a substantial proportion of pacemaker-dependent patients. Just as there is undoubted evidence that RV apical pacing is injurious, there is emerging evidence that pacing from the RV septum is associated with a shorter duration of activation, improved haemodynamics, and less LV remodelling. The move from traditional RV apical pacing to RV septal pacing requires a change in mindset for many practitioners. The anatomical landmarks and electrocardiograph features of RV septal pacing are well described and easily recognized. While active fixation is required to place the lead on the septum, shaped stylets are now available to assist the implanter. In addition, concerns about the stability and longevity of steroid-eluting active fixation leads have proven to be unfounded. We therefore encourage all implanters to adopt RV septal pacing to minimize the potential of harm to their patients. PMID:21846639

  2. Right-ventricular and left-ventricular function parameters in patients with and without outflow tract patches as determined by radionuclide methods at least 10 years following surgical correction of Fallot's tetralogy in the adult individuals

    International Nuclear Information System (INIS)

    During a period starting in 1983 and ending in April 1984 radionuclide ventriculography was performed in 26 patients subjected to surgical correction of Fallot's tetralogy after having reached adulthood. They were divided into two groups according to the surgical methods used. Patients showing no right-ventricular outflow patch were assigned to group I, while group II was made up of individuals that had received outflow tract patches of Dacron or Teflon for pressure reduction in the right ventricle. The parameters registered during radionuclide ventriculography, in which the tracer substance TC 99m was administered into a peripheral vein, included the endiastolic volume, endsystolic volume, stroke volume, global ejection fraction and cardiac index. For resting patients, these values were calculated using the first-pass technique, the determinations during exercise on the ergometer were based on equilibrium radionuclide ventriculography. It could be concluded from the results obtained here that non-invasive endocardial scintigraphy is a sensitive method that can be used both at rest and during exercise on the ergometer to detect function disorders of the right and left ventricles. (orig./MG)

  3. Stenting of the right ventricular outflow tract in the high-risk infant with cyanotic teratology of Fallot.

    Science.gov (United States)

    Castleberry, Chesney D; Gudausky, Todd M; Berger, Stuart; Tweddell, James S; Pelech, Andrew N

    2014-03-01

    Neonatal tetralogy of Fallot (TOF) repair carries an increased risk of low birthweight or premature infants. Studies are investigating stents in the right ventricular outflow tract (RVOT) as an alternative to aortopulmonary shunts. The authors review their institutional experience with RVOT stenting in the high-risk infant with TOF. Data on sequential patients who received RVOT stents were reviewed, with collection of their surgical, echocardiographic, and catheterization data. Size-matched control subjects were identified and outcomes compared. Six infants went to the catheterization lab for RVOT stenting from 2008 to 2010. Five of these patients had placement of an RVOT stent after balloon dilation. The median saturations were 71% on 48% fraction of inspired oxygen (FiO2), with improvement to 94% (p < 0.001) on 39% FiO2 24 h after stent placement. As shown by echocardiography, the diameter of the median right pulmonary artery (RPA) was 2.6 mm (z-score, -3.3), and the diameter of the left pulmonary artery (LPA) was 2.0 mm (z-score, -4.5). Repeat echocardiography before surgery showed a statistically significant increase in RPA and LPA size as well as a modified McGoon ratio (p < 0.05). Four of the five patients subsequently underwent TOF repair. No stent fractures occurred. One patient had repair 10 days after stent placement secondary to stent malposition and tricuspid valve injury. The authors' experience with stents in the RVOT of TOF patients has yielded good results, with significant improvement in oxygen saturations. Patients had successful elective surgical repair and stent removal without longer cardiopulmonary bypass times or recognizable complications compared with shunted patients. PMID:24096718

  4. Beta2-adrenoceptor gene variant Arg16Gly is associated with idiopathic ventricular outflow-tract tachycardia

    Institute of Scientific and Technical Information of China (English)

    RAN Yu-qin; LI Ning; YANG Ying; CHEN Jing-zhou; FENG Li; ZHANG Shu; PU Jie-lin

    2010-01-01

    Background Imbalance of the sympathetic nervous system was involved in the pathogenesis of idiopathic ventricular outflow-tract tachycardia (IVOT). We aimed to investigate whether the major genetic variants in β1-and β2-adrenoceptors and GNB3 C825T were associated with IVOT and verapamil sensitive idiopathic left ventricular tachycardia (ILVT).Methods Patients with IVOT and ILVT from December 2005 to December 2007 were consecutively enrolled into this study. Controls were randomly selected from the community-based inhabitants. Five genetic variants, Ser49Gly and Gly389Arg in the β1-adrenoceptor, Arg16Gly and Gln27Glu in the β2-adrenoceptor and GNB3 C825T, were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis.Results A total of 227 patients with IVOT and 110 patients with ILVT were included. Genotyping revealed that the 16Gly allele of Arg16Gly variant of β2-adrenoceptor was associated with a higher risk of IVOT (OR:1.40, 95% CI: 1.12-1.75,P=0.003 in the addictive model and OR:. 1.62, 95% CI: 1.14-2.31, P=0.007 in the dominant model). Patients with Gly16Gln27 haplotype also had a higher risk of IVOT (OR: 1.38, 95% CI: 1.11-1.73, P=0.012). Other four variants,including Ser49Gly and Arg389Gly in β1-adrenoceptor, GIn27Glu in β2-adrenoceptor and GNB3 C825T, did not differ between patients with IVOT and controls. In patients with ILVT, no significant difference was found in these five variants compared with controls.Conclusions Arg16Gly in β2-adrenoceptor is significantly associated with IVOT in Chinese Han population. Major genetic variants in β1- and β2-adrenoceptor and GNB3 C825T may not be associated with ILVT. These data suggest a different arrhythmogenic mechanism in IVOT and ILVT.

  5. Urinary tract infection in children after cardiac surgery: Incidence, causes, risk factors and outcomes in a single-center study.

    Science.gov (United States)

    Kabbani, Mohamed S; Ismail, Sameh R; Fatima, Anis; Shafi, Rehana; Idris, Julinar A; Mehmood, Akhter; Singh, Reetam K; Elbarabry, Mahmoud; Hijazi, Omar; Hussein, Mohamed A

    2016-01-01

    Nosocomial urinary tract infection (UTI) increases hospitalization, cost and morbidity. In this cohort study, we aimed to determine the incidence, risk factors, etiology and outcomes of UTIs in post-operative cardiac children. To this end, we studied all post-operative patients admitted to the Pediatric Cardiac Intensive Care Unit (PCICU) in 2012, and we divided the patients into two groups: the UTI (UTI group) and the non-UTI (control group). We compared both groups for multiple peri-operative risk factors. We included 413 children in this study. Of these, 29 (7%) had UTIs after cardiac surgery (UTI group), and 384 (93%) were free from UTIs (control group). All UTI cases were catheter-associated UTIs (CAUTIs). A total of 1578 urinary catheter days were assessed in this study, with a CAUTI density rate of 18 per 1000 catheter days. Multivariate logistic regression analysis demonstrated the following risk factors for CAUTI development: duration of urinary catheter placement (pcongenital abnormalities of kidney and urinary tract (CAKUT) (purinary catheter, the presence of CAKUT, and the presence of syndromes comprised the main risk factors for CAUTI. Gram-negative organisms were the main causes for CAUTI, and one-third of them found to be resistant in this single-center study. PMID:26829892

  6. The Different Substrate Characteristics of Arrhythmogenic Triggers in Idiopathic Right Ventricular Outflow Tract Tachycardia and Arrhythmogenic Right Ventricular Dysplasia: New Insight from Noncontact Mapping.

    Directory of Open Access Journals (Sweden)

    Van Buu Dan Do

    Full Text Available The aim of this study was to investigate the different substrate characteristics of repetitive premature ventricular complexed (PVC trigger sites by the non-contact mapping (NCM.Thirty-five consecutive patients, including 14 with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC and 21 with idiopathic right ventricular outflow tract tachycardia (RVOT VT, were enrolled for electrophysiological study and catheter ablation guided by the NCM. Substrate and electrogram (Eg characteristics of the earliest activation (EA and breakout (BO sites of PVCs were investigated, and these were confirmed by successful PVC elimination.Overall 35 dominant focal PVCs were identified. PVCs arose from the focal origins with preferential conduction, breakout, and spread to the whole right ventricle. The conduction time and distance from EA to BO site were both longer in the ARVC than the RVOT group. The conduction velocity was similar between the 2 groups. The negative deflection of local unipolar Eg at the EA site (EA slope3,5,10ms values was steeper in the RVOT, compared to ARVC patients. The PVCs of ARVC occurred in the diseased substrate in the ARVC patients. More radiofrequency applications were required to eliminate the triggers in ARVC patients.The substrate characteristics of PVC trigger may help to differentiate between idiopathic RVOT VT and ARVC. The slowing and slurred QS unipolar electrograms and longer distance from EA to BO in RVOT endocardium suggest that the triggers of ARVC may originate from mid- or sub-epicardial myocardium. More extensive ablation to the trigger site was required in order to create deeper lesions for a successful outcome.

  7. Association of neuropeptide Y promoter polymorphism (rs16147) with perceived stress and cardiac vagal outflow in humans.

    Science.gov (United States)

    Chang, Hsin-An; Fang, Wen-Hui; Chang, Tieh-Ching; Huang, San-Yuan; Chang, Chuan-Chia

    2016-01-01

    Neuropeptide Y (NPY) is involved in resilience to stress, and higher vagal (parasympathetic) activity has been associated with greater stress resilience. Thus, we examined whether rs16147, a functional promoter polymorphism (C>T) of the NPY gene, could influence vagal tone during chronic high stress levels. NPY genotyping, chronic psychological stress level measurement (using the Perceived Stress Scale [PSS]), cardiac autonomic function assessment (using short-term heart rate variability [HRV]) were performed in 1123 healthy, drug-free Han Chinese participants who were divided into low- and high-PSS groups. In the high-PSS group (n = 522), the root mean square of successive heartbeat interval differences and high frequency power (both HRV indices of parasympathetic activity) were significantly increased in T/T homozygotes compared to C/C homozygotes. However, no significant between-genotype difference was found in any HRV variable in the low-PSS group (n = 601). Our results are the first to demonstrate that functional NPY variation alters chronic stress-related vagal control, suggesting a potential parasympathetic role for NPY gene in stress regulation. PMID:27527739

  8. Supravalvular aortic stenosis with sudden cardiac death

    Directory of Open Access Journals (Sweden)

    Pradeep Vaideeswar

    2015-01-01

    Full Text Available Sudden cardiac death (SCD most commonly results from previously undiagnosed congenital, acquired, or hereditary cardiac diseases. Congenital aortic valvular, subvalvular, and supravalvular disease with left ventricular outflow tract obstruction is an important preventable cause of sudden death. This report documents sudden death presumably due to acute myocardial ischemia in a young male with an undiagnosed supravalvular aortic stenosis (SVAS due to a rare association of isolation of coronary sinuses of Valsalva. Congenital supravalvular pulmonary stenosis and mitral valvular dysplasia were also present.

  9. Right-ventricular and left-ventricular function parameters in patients with and without outflow tract patches as determined by radionuclide methods at least 10 years following surgical correction of Fallot's tetralogy in the adult individuals. Nuklearmedizinische Bestimmung der rechts- und linksventrikulaeren Funktionsparameter von Patienten ohne und mit Ausflusstraktpatch - mindestens 10 Jahre nach operativer Korrektur der Fallot'schen Tetralogie im Erwachsenenalter

    Energy Technology Data Exchange (ETDEWEB)

    Seidel, P.

    1988-12-15

    During a period starting in 1983 and ending in April 1984 radionuclide ventriculography was performed in 26 patients subjected to surgical correction of Fallot's tetralogy after having reached adulthood. They were divided into two groups according to the surgical methods used. Patients showing no right-ventricular outflow patch were assigned to group I, while group II was made up of individuals that had received outflow tract patches of Dacron or Teflon for pressure reduction in the right ventricle. The parameters registered during radionuclide ventriculography, in which the tracer substance TC 99m was administered into a peripheral vein, included the endiastolic volume, endsystolic volume, stroke volume, global ejection fraction and cardiac index. For resting patients, these values were calculated using the first-pass technique, the determinations during exercise on the ergometer were based on equilibrium radionuclide ventriculography. It could be concluded from the results obtained here that non-invasive endocardial scintigraphy is a sensitive method that can be used both at rest and during exercise on the ergometer to detect function disorders of the right and left ventricles. (orig./MG).

  10. Management of high-risk reentry sternotomy in an infant for repair of a giant pseudoaneurysm of the right ventricular outflow tract

    Directory of Open Access Journals (Sweden)

    Bryan G Maxwell

    2014-01-01

    Full Text Available Improved survival from congenital heart disease has led to an increasing need for complex reoperation by reentrant sternotomy. Peripheral cannulation and initiation of cardiopulmonary bypass prior to sternotomy to avoid the risk of cardiac injury and massive hemorrhage is an option in adults and larger children, but femoral vessel size precludes this strategy in infants. We describe the management of a high-risk reentry sternotomy in an infant for repair of a giant pseudoaneurysm after prior homograft repair of tetralogy of Fallot, using surgical dissection for suprasternal cannulation of the innominate artery and subxyphoid cannulation of the inferior vena cava.

  11. Late outcome of right ventricular outflow tract repair using bicuspid pulmonary prosthesis in tetralogy of Fallot surgery repair: case report Resultado tardio da reconstrução da via de saída do ventrículo direito com prótese pulmonar bicúspide na correção da tetralogia de Fallot: relato de caso

    Directory of Open Access Journals (Sweden)

    Miguel Angel Maluf

    2009-12-01

    Full Text Available We present a case of a 19 year-old female patient, with tetralogy of Fallot and hypoplastic pulmonary ring. Diagnosis was performed by echocardiography and cardiac catheterization. The surgical repair was performed at the age of 2 years old. A right ventricular outflow tract remodeling was performed using a porcine pulmonary bicuspid prosthesis. The patient presented a uneventful follow-up during 17 years. Postoperative assessment has shown: mild pulmonary insufficiency and mild pulmonary ventricle gradient, satisfactory right ventricular performance and prosthesis not presenting calcification. This is an option to correct the tetralogy of Fallot adopted by our Institution in the last two decades.É apresentado o caso de uma paciente de 19 anos de idade, sexo feminino, portadora de tetralogia de Fallot com anel pulmonar hipoplásico. O diagnóstico foi feito com ecoDopplercardiograma e cateterismo cardíaco. A correção cirúrgica foi realizada com 2 anos de idade. Para a reconstrução da valva pulmonar e via de saída do ventrículo foi utilizada prótese bivalvular pulmonar porcina. A paciente teve boa evolução clínica durante 17 anos. A avaliação pós-operatória demonstrou: discreta insuficiência pulmonar, discreto gradiente transvalvar pulmonar, desempenho do ventrículo direito preservado e prótese pulmonar sem calcificação. Esse é o procedimento adotado pela nossa Instituição para a correção da tetralogia de Fallot, nos últimos 20 anos.

  12. Balloon dilatation of alimentary tract strictures

    International Nuclear Information System (INIS)

    From a series of balloon dilatations of alimentary tract strictures 11 patients with different types of gastric and oesophagogastric anastomotic stenoses are reported. The dilatation of gastric outflow tract obstructions was highly effective in the treatment of retention. In 7 out of 8 cases with gastric outflow stenosis surgery could be entirely avoided and replaced by balloon dilatation. The importance of eliminating retention in the healing of gastric ulcer is discussed. Fistulation in oesophagogastric anastomoses due to stenosis of the outflow portion was successfully treated. The importance of achieving a free outflow tract in order to prevent insufficiency of the anastomosis and formation of a fistula is stressed. (orig.)

  13. ANAESTHETIC MANAGEMENT OF TETRALOGY OF FALLOT COMING FOR NON - CARDIAC SURGERY: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Dilesh

    2015-03-01

    Full Text Available Tetralogy of Fallot is a cyanotic congenital heart disorder and includes ventricular septal defect , right ventricular outflow tract obstruction (pulmonic stenosis , right ventricular hypertrophy and overriding of aorta . Anaesthetic goals in these patients is to maintain or increase the systemic vascular resistance minimize pulmonary vascular resistance and provide mild cardiac depression . Here we present a report of anaesthetic management of a 5 year old boy with t etralogy of fallot coming for cleft lip and cleft palate repair .

  14. Importance of Delayed Enhanced Cardiac MRI Imaging in Idiopathic RVOT-VT: Differentiating Mimics Including Early Stage ARVC and Cardiac Sarcoidosis

    Directory of Open Access Journals (Sweden)

    Carlos Macias, MD; Keijiro Nakamura, MD; Roderick Tung, MD; Noel G. Boyle, MD PhD; Kalyanam Shivkumar, MD, PhD and Jason S. Bradfield, MD.

    2014-12-01

    Full Text Available Abstract: A detailed understanding of cardiac anatomy and pathophysiology is necessary to optimize catheter ablation procedural success for patients with symptomatic ventricular tachycardia (VT/premature ventricular contractions (PVCs of outflow tract origin. Comprehensive imaging with cardiac magnetic resonance imaging (cMRI is now at the forefront of procedural planning for complex ventricular arrhythmia ablation for patients with structural heart disease, but is increasingly used in patients with presumed “idiopathic” outflow VT/PVCs as well. cMRI with late gadolinium enhancement (LGE can localize small regions of myocardial scar from previous myocardial infarction, fibrosis from non-ischemic cardiomyopathy, or edema/fibrosis from inflammatory disorders and help define targets for ablation. LGE, in combination with structural assessment, can help differentiate true idiopathic outflow VT/PVCs from those caused by early stage disease secondary to more significant pathology, such as arrhythmogenic right ventricular cardiomyopathy or cardiac sarcoidosis. We review the benefits of cMRI with LGE for patients with VT/PVCs of outflow origin.

  15. Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the rat

    Directory of Open Access Journals (Sweden)

    Goodchild Ann K

    2010-10-01

    Full Text Available Abstract Background Cardiac vagal preganglionic neurons (CVPN are responsible for the tonic, reflex and respiratory modulation of heart rate (HR. Although CVPN receive GABAergic and glutamatergic inputs, likely involved in respiratory and reflex modulation of HR respectively, little else is known regarding the functions controlled by ionotropic inputs. Activation of g-protein coupled receptors (GPCR alters these inputs, but the functional consequence is largely unknown. The present study aimed to delineate how ionotropic GABAergic, glycinergic and glutamatergic inputs contribute to the tonic and reflex control of HR and in particular determine which receptor subtypes were involved. Furthermore, we wished to establish how activation of the 5-HT1A GPCR affects tonic and reflex control of HR and what ionotropic interactions this might involve. Results Microinjection of the GABAA antagonist picrotoxin into CVPN decreased HR but did not affect baroreflex bradycardia. The glycine antagonist strychnine did not alter HR or baroreflex bradycardia. Combined microinjection of the NMDA antagonist, MK801, and AMPA antagonist, CNQX, into CVPN evoked a small bradycardia and abolished baroreflex bradycardia. MK801 attenuated whereas CNQX abolished baroreceptor bradycardia. Control intravenous injections of the 5-HT1A agonist 8-OH-DPAT evoked a small bradycardia and potentiated baroreflex bradycardia. These effects were still observed following microinjection of picrotoxin but not strychnine into CVPN. Conclusions We conclude that activation of GABAA receptors set the level of HR whereas AMPA to a greater extent than NMDA receptors elicit baroreflex changes in HR. Furthermore, activation of 5-HT1A receptors evokes bradycardia and enhances baroreflex changes in HR due to interactions with glycinergic neurons involving strychnine receptors. This study provides reference for future studies investigating how diseases alter neurochemical inputs to CVPN.

  16. Cardiac output determined by echocardiography in patients with cirrhosis: comparison with the indicator dilution technique

    DEFF Research Database (Denmark)

    Andersen, Ulrik B; Møller, Søren; Bendtsen, Flemming; Henriksen, Jens H

    2003-01-01

    technique (CO(I)). METHODS: Twelve patients with cirrhosis were studied. CO(d) was measured as the spatial mean velocity of the left ventricular outflow tract, multiplied by the cross-sectional area and the heart rate. CO(I) was determined by the standard indicator dilution technique after injection of 125I......BACKGROUND/AIMS: Measurement of cardiac output in hyperkinetic patients with cirrhosis by Doppler echocardiography is increasingly reported, but has not been validated. We have compared simultaneous measurements of cardiac output by Doppler echocardiography (CO(d)) and by the indicator dilution...... with the Doppler technique. CONCLUSION: Doppler measurements of cardiac output in groups of patients with cirrhosis are accurate with respect to the group mean, but marked disagreements of over- and underestimation were seen in individual patients. The reproducibility of the Doppler technique is...

  17. Síncope em pacientes com extra-sístoles de via de saída de ventrículo direito e sem cardiopatia estrutural aparente Syncope in patients with right ventricle outflow tract premature beats and no apparent structural cardiopathy

    Directory of Open Access Journals (Sweden)

    Ana Cristina Ludovice

    2006-11-01

    ventricular premature beats, with right ventricle outflow tract morphology (RVOT and no apparent structural cardiopathy. METHODS: Ninety patients (66 women, mean age 40.2±16.95 years of age with monomorphic premature beats originated at RVOT were evaluated prospectively. Fifty-four patients reported syncopes or near-syncopes associated to palpitations or not; twenty-seven presented palpitations with no pre-syncope or syncope, and nine were asymptomatic. All patients were submitted to echocardiogram, high resolution ECG and cardiac MRI to rule out structural cardiopathy, to exertion test to rule out adrenergic dependent ventricular tachycardia, and ECG prolonged outpatient monitoring (Holter and symptomatic events monitor to correlate symptoms and ventricular arrhythmias. Investigation on the susceptibility to neurocardiogenic syncope was evaluated by Tilt Table Test (TTT. Groups were compared regarding gender, age, premature beats frequency and complexity, at exertion or not, TTT results and clinical course. RESULTS: In the syncope and pre-syncope groups, TTT was positive for 38% of cases, and in groups with palpitations and assymptomatics, it was positive for 11% (p = 0.0257. After recommendations and treatment of neurocardiogenic syncope, 85% of syncope and pre-syncope patients and positive TTT was asymptomatic along the 40-month follow-up. Two patients with syncope and negative TTT presented spontaneous, sustained ventricular tachycardia during clinic course. CONCLUSION: The prevalence of neurocardiogenic syncope in patients with idiopathic RVOT premature beats is high. Patients with recurrent, unexplained syncope and idiopathic VE must be kept under investigation.

  18. Massive molecular outflows

    OpenAIRE

    Beuther, H.; Schilke, P.; Menten, K. M.; Walmsley, C. M.; Sridharan, T. K.; Wyrowski, F.

    2001-01-01

    We present a mapping study of massive molecular outflows in 26 high-mass star-forming regions at 11'' spatial resolution. Bipolar morpholgy is found in 80% of the sources and the collimation is higher than previously thought. Additionally, we find that well known low-mass correlations continue up to the high-mass regime, and accretion rates are around 10^(-4) Msun/yr rising as high as 10^(-3) Msun/yr. A tight correlation between the outflow and the core mass is established, implying that the ...

  19. Outflows and Shock Chemistry

    Science.gov (United States)

    Tafalla, M.

    2016-05-01

    Bipolar outflows result from the supersonic ejection of material by a protostar, and constitute one of the most characteristic signposts of stellar birth. They also provide ideal targets to test chemical models, and can serve as templates for more complex systems of galactic and extragalactic astronomy where supersonic interactions between gas components take place.

  20. Metallicity and Quasar Outflows

    CERN Document Server

    Wang, Huiyuan; Yuan, Weimin; Wang, Tinggui

    2012-01-01

    Correlations are investigated of the outflow strength of quasars, as measured by the blueshift and asymmetry index (BAI) of the CIV line (Wang et al. 2011), with intensities and ratios of broad emission lines, based on composite quasar spectra built from the Sloan Digital Sky Survey. We find that most of the line ratios of other ions to CIV prominently increases with BAI. These behaviors can be well understood in the context of increasing metallicity with BAI. The strength of dominant coolant, CIV line, decreases and weak collisionally excited lines increase with gas metallicity as a result of the competition between different line coolants. Using SiIV+OIV]/CIV as an indicator of gas metallicity, we present, for the first time, a strong correlation between the metallicitiy and the outflow strength of quasars over a wide range of 1.7 to 6.9 times solar abundance. Our result implies that the metallicity plays an important role in the formation of quasar outflows, likely via affecting outflow acceleration. This ...

  1. [Assessment of risk of sudden cardiac death in patients with hypertrophic cardiomyopathy].

    Science.gov (United States)

    Attanasio, Philipp; Blaschke, Florian; Pieske, Burkert; Tschöpe, Carsten; Haverkamp, Wilhelm

    2016-07-01

    Hypertrophic cardiomyopathy (HCM) is a hereditary disease characterized by left ventricular hypertrophy with or without concomitant outflow tract obstruction. Identification of patients with HCM who are at high risk of sudden cardiac death (SCD) is crucial as those patients are likely to benefit from an implantable cardioverter defibrillator (ICD). Based on the HCM Risk-SCD study published in 2013, that included 3675 HCM patients with 24 313 years of follow up, a new clinical risk prediction model for sudden cardiac death was developed. This model was included in the recently released 2014 ESC guidelines. This review summarizes the changes in the prediction model and the resulting recommendations and discusses potential risks and limitations of the new score. PMID:27404936

  2. Primary Cardiac Angiosarcoma in a Middle Aged Woman

    Science.gov (United States)

    Jalalian, Rozita; Naghshvar, Farshad; Habibi, Valiollah; Hakakian, Vahid; Namazi, Morteza

    2015-01-01

    Introduction: Primary cardiac angiosarcoma is the most common primary sarcoma in adults between the 3rd and 4th decades of life. Nearly 90% of angiosarcomas occur in the right atrium, which is responsible for the late onset of symptoms. Case Presentation: We presented a 56-year-old woman admitted to our center with lung emboli symptoms. Transthoracic and transesophageal echocardiography (TTE and TEE) demonstrated very large size (more than 10 cm diameter) multilobulated mass with mobile particles extended from the right atrium to the right ventricle and the right ventricular outflow tract which destructed the right atrium (RA) wall and penetrated to the pericardial space. Conclusions: Unfortunately the tumor was unresectable and just an incisional biopsy was performed. She received chemotherapy as palliative care. PMID:26328065

  3. Functional cardiac MRI for assessment of aortic valve disease

    International Nuclear Information System (INIS)

    Aortic valve disease shows a rising incidence with the increasing mean age of Western populations. The detection of hemodynamic parameters, which transcends the mere assessment of valve morphology, has an important future potential concerning classification of the severity of disease. MRI allows a non-invasive and a spatially flexible view of the aortic valve and the adjacent anatomic region, left ventricular outflow tract (LVOT) and ascending aorta. Moreover, the technique allows the determination of functional hemodynamic parameters, such as flow velocities and effective orifice areas. The new approach of a serial systolic planimetry velocity-encoded MRI sequence (VENC-MRI) facilitates the sizing of blood-filled cardiac structures with the registration of changes in magnitude during systole. Additionally, the subvalvular VENC-MRI measurements improve the clinically important exact determination of the LVOT area with respect to its specific eccentric configuration and its systolic deformity. (orig.)

  4. Galaxy Outflows Without Supernovae

    CERN Document Server

    Sur, Sharanya; Ostriker, Eve C

    2016-01-01

    High surface density, rapidly star-forming galaxies are observed to have $\\approx 50-100\\,{\\rm km\\,s^{-1}}$ line-of-sight velocity dispersions, which are much higher than expected from supernova driving alone, but may arise from large-scale gravitational instabilities. Using three-dimensional simulations of local regions of the interstellar medium, we explore the impact of high velocity dispersions that arise from these disk instabilities. Parametrizing disks by their surface densities and epicyclic frequencies, we conduct a series of simulations that probe a broad range of conditions. Turbulence is driven purely horizontally and on large scales, neglecting any energy input from supernovae. We find that such motions lead to strong global outflows in the highly-compact disks that were common at high redshifts, but weak or negligible mass loss in the more diffuse disks that are prevalent today. Substantial outflows are generated if the one-dimensional horizontal velocity dispersion exceeds $\\approx 35\\,{\\rm km\\...

  5. Electrophysiological effects of lidocaine on myocardial tissue in guinea-pig left ventricular outflow tract under conditions of hypoxia, acidosis and treatment with epinephrine%利多卡因对低氧、酸中毒及肾上腺素条件下豚鼠左心室流出道心肌组织电活动的影响

    Institute of Scientific and Technical Information of China (English)

    赵兰平; 王雪芳; 杜会博; 薛淑芳; 陈彦静

    2013-01-01

    AIM; To study the electrophysiological effects of lidocaine on the myocardial tissue in guinea-pig left ventricular outflow tract under the conditions of hypoxia, acidosis and treatment with epinephrine. METHODS: The action potentials of pacemaker cells in guinea-pig left ventricular outflow tract were recorded by conventional technique with intracellular microelectrodes. The effects of lidocaine on the spontaneous slow response potentials were investigated under the conditions of hypoxia, acidosis and treatment with epinephrine (EPI). RESULTS: Lidocaine markedly decreased the rate of pacemaker firing ( RPF) , the velocity of diastolic depolarization ( VDD) , the maximal rate of depolarization ( Vmax), the maximal diastolic potential (MDP) and the amplitude of action potential ( APA). Lidocaine also shortened the 50% and 80% of duration of action potential (APD50 and APD80). At the concentrations from 0.1 μmol/L to 10 μmol/L, the effects of lidocaine were more significant. Under the condition of hypoxia and perfusion with deprived glucose content for 15 min, VDD, RPF, Vmax, MDP and APA significantly decreased, and APD50 notably shortened. Under the condition of hypoxia, lidocaine at 1 μmol/L significantly decreased VDD, RPF, Vmax and APA as compared with the cells treated with hypoxia only. Perfusion with pH 6.8 solution for 10 min, VDD, RPF, Vmax and APA significantly decreased, MDP notably increased, and APD50 and APD80 markedly shortened. Under the condition of acidosis for 10 min, lidocaine significantly decreased VDD, RPF and Vmax, and lengthened APD50 and APD80 as compared with the cells under the condition of acidosis alone. Perfusion with EPI at 10 μmol/L for 10 min resulted in significant increases in VDD, RPF, Vmax, MDP and APA, and notable shortenings of APD50 and APD80, were also observed. Compared with 10 μmol/L EPI group, 1 μmol/L lidocaine +10 μmol/L EPI significantly reduced VDD, RPF, MDP and APA, and lengthened APD50, and APD80. CONCLUSION

  6. Protostellar outflow-driven turbulence

    CERN Document Server

    Matzner, C D

    2007-01-01

    Protostellar outflows crisscross the regions of star cluster formation, stirring turbulence and altering the evolution of the forming cluster. We model the stirring of turbulent motions by protostellar outflows, building on an observation that the scaling law of supersonic turbulence implies a momentum cascade analogous to the energy cascade in Kolmogorov turbulence. We then generalize this model to account for a diversity of outflow strengths, and for outflow collimation, both of which enhance turbulence. For a single value of its coupling coefficient the model is consistent with turbulence simulations by Li & Nakamura and, plausibly, with observations of the NGC 1333 cluster-forming region. Outflow-driven turbulence is strong enough to stall collapse in cluster-forming regions for several crossing times, relieving the mismatch between star formation and turbulent decay rates. The predicted line-width-size scaling implies radial density indices between -1 and -2 for regions supported by outflow-driven tu...

  7. Magnetic propeller outflows

    OpenAIRE

    Lovelace, R. V. E.; Romanova, M. M.; Bisnovatyi-Kogan, G. S.

    1998-01-01

    A model is developed for magnetic `propeller'-driven outflows which cause a rapidly rotating magnetized star accreting from a disk to spin-down. Energy and angular momentum lost by the star goes into expelling most of the accreting disk matter. The theory gives an expression for the effective Alfven radius $R_A$ (where the inflowing matter is effectively stopped) which depends on the mass accretion rate, the star's mass and magnetic moment, and the star's rotation rate. The model points to a ...

  8. The effect of Shen-Fu on gastrointestinal tract injury and its potential mechanism during cardio-pulmonary bypass in patients undergoing cardiac surgery

    Institute of Scientific and Technical Information of China (English)

    夏中元; 詹丽英; 何宇红; 刘先义

    2003-01-01

    Objective: To investigate the effect of Shen-Fu (SF) injection on gastrointestinal tract injury and its potential mechanism. Methods: Thirty-eight patients undergoing elective open heart surgery were assigned to Group C (control group, n=18) and Group SF (n=20) randomly. In Group SF, the patients received intravenous injection of SF (0.5 ml/kg) at the beginning of the surgery followed by a continuous infusion of 100 ml SF (1.0 ml/kg) solution diluted by saline at a rate of 0.004 ml*Kg-1*min-1with a Grasby pump. The control group was injected with normal saline in the same volume. Gastric intramucosal pH (pHi), activity of blood diamine oxidase (DAO), and concentrations of blood LPS and IL-6 were measured before CPB (S0) and 1 h (S1) and 2 h (S2) after aortic declamping, respectively.Results: In Group C, pHi value was significantly lower at S1 and S2 than at S0 ( mean P<0.01) and blood DAO and concentrations of LPS and IL-6 were significantly higher at S1 and S2 than at S0 ( meanP<0.01). In Group SF, pHi was obviously lower at S1 and S2 than at S0 (P<0.05) but LPS and IL-6 levels and DAO were higher at S0 (mean P<0.05). Blood DAO and LPS level demonstrated significant negative correlations with pHi (mean P<0.01) while LPS concentration showed a positive correlation with blood DAO (P<0.01) and IL-6 concentration(P<0.05). At S1 and S2 after aortic declamping, the levels of pHi were higher in Group SF than in Group C (mean P<0.01 ) but DAO and LPS and IL-6 levels were significantly lower in Group SF than in Group C ( P<0.01).Conclusions: SF has a protective effect on gastrointestinal tract and can reduce inflammatory actions.

  9. Human fetal cardiac progenitors: The role of stem cells and progenitors in the fetal and adult heart.

    Science.gov (United States)

    Bulatovic, Ivana; Månsson-Broberg, Agneta; Sylvén, Christer; Grinnemo, Karl-Henrik

    2016-02-01

    The human fetal heart is formed early during embryogenesis as a result of cell migrations, differentiation, and formative blood flow. It begins to beat around gestation day 22. Progenitor cells are derived from mesoderm (endocardium and myocardium), proepicardium (epicardium and coronary vessels), and neural crest (heart valves, outflow tract septation, and parasympathetic innervation). A variety of molecular disturbances in the factors regulating the specification and differentiation of these cells can cause congenital heart disease. This review explores the contribution of different cardiac progenitors to the embryonic heart development; the pathways and transcription factors guiding their expansion, migration, and functional differentiation; and the endogenous regenerative capacity of the adult heart including the plasticity of cardiomyocytes. Unfolding these mechanisms will become the basis for understanding the dynamics of specific congenital heart disease as well as a means to develop therapy for fetal as well as postnatal cardiac defects and heart failure. PMID:26421632

  10. Intra-cardiac echocardiography in alcohol septal ablation

    DEFF Research Database (Denmark)

    Cooper, Robert M; Shahzad, Adeel; Newton, James;

    2015-01-01

    Alcohol septal ablation (ASA) in hypertrophic obstructive cardiomyopathy reduces left ventricular outflow tract gradients. A third of patients do not respond; inaccurate localisation of the iatrogenic infarct can be responsible. Transthoracic echocardiography (TTE) using myocardial contrast can be...

  11. Particle Acceleration in Relativistic Outflows

    Science.gov (United States)

    Bykov, Andrei; Gehrels, Neil; Krawczynski, Henric; Lemoine, Martin; Pelletier, Guy; Pohl, Martin

    2012-01-01

    In this review we confront the current theoretical understanding of particle acceleration at relativistic outflows with recent observational results on various source classes thought to involve such outflows, e.g. gamma-ray bursts, active galactic nuclei, and pulsar wind nebulae. We highlight the possible contributions of these sources to ultra-high-energy cosmic rays.

  12. Non-invasive cardiac output trending during exercise recovery on a bathroom-scale-based ballistocardiograph

    International Nuclear Information System (INIS)

    Cardiac ejection of blood into the aorta generates a reaction force on the body that can be measured externally via the ballistocardiogram (BCG). In this study, a commercial bathroom scale was modified to measure the BCGs of nine healthy subjects recovering from treadmill exercise. During the recovery, Doppler echocardiogram signals were obtained simultaneously from the left ventricular outflow tract of the heart. The percentage changes in root-mean-square (RMS) power of the BCG were strongly correlated with the percentage changes in cardiac output measured by Doppler echocardiography (R2 = 0.85, n = 275 data points). The correlation coefficients for individually analyzed data ranged from 0.79 to 0.96. Using Bland–Altman methods for assessing agreement, the mean bias was found to be −0.5% (±24%) in estimating the percentage changes in cardiac output. In contrast to other non-invasive methods for trending cardiac output, the unobtrusive procedure presented here uses inexpensive equipment and could be performed without the aid of a medical professional

  13. Scaling ultraviolet outflows in Seyferts

    OpenAIRE

    Stoll, R.; S Mathur; Krongold, Y.; Nicastro, F.

    2009-01-01

    X-ray and UV absorbing outflows are frequently seen in AGN and have been cited as a possible feedback mechanism. Whether or not they can provide adequate feedback depends on how massive they are and how much energy they carry, but it depends in a more fundamental way upon whether they escape the potential of the black hole. If the outflows have reached their asymptotic velocity when we observe them, then all of these properties critically depend on the radius of the outflow: a value which is ...

  14. Energy exchanges in reconnection outflows

    CERN Document Server

    Lapenta, Giovanni; Newman, Davd L; Markidis, Stefano

    2016-01-01

    Reconnection outflows are highly energetic directed flows that interact with the ambient plasma or with flows from other reconnection regions. Under these conditions the flow becomes highly unstable and chaotic, as any flow jets interacting with a medium. We report here massively parallel simulations of the two cases of interaction between outflow jets and between a single outflow with an ambient plasma. We find in both case the development of a chaotic magnetic field, subject to secondary reconnection events that further complicate the topology of the field lines. The focus of the present analysis is on the energy balance. We compute each energy channel (electromagnetic, bulk, thermal, for each species) and find where the most energy is exchanged and in what form. The main finding is that the largest energy exchange is not at the reconnection site proper but in the regions where the outflowing jets are destabilized.

  15. Scaling ultraviolet outflows in Seyferts

    CERN Document Server

    Stoll, R; Krongold, Y; Nicastro, F

    2009-01-01

    X-ray and UV absorbing outflows are frequently seen in AGN and have been cited as a possible feedback mechanism. Whether or not they can provide adequate feedback depends on how massive they are and how much energy they carry, but it depends in a more fundamental way upon whether they escape the potential of the black hole. If the outflows have reached their asymptotic velocity when we observe them, then all of these properties critically depend on the radius of the outflow: a value which is difficult to measure. The tightest limit on the distance of an X-ray warm absorber from the ionizing source is that of Krongold et al. (2007) for NGC 4051. We use NGC 4051 to model other observed UV outflows, and find that on the whole they may not provide meaningful feedback. The outflow velocities are below or just above the escape velocity of the black hole. This may be because they are not yet fully accelerated, or the duty cycle of high-velocity outflows may be small. Another possibility is that they may only provide...

  16. Ablação com radiofreqüência de extra-sístoles da via de saída do ventrículo direito Radiofrequency catheter ablation of premature ventricular contractions originating in the right ventricular outflow tract

    Directory of Open Access Journals (Sweden)

    Francisco C. C. Darrieux

    2007-03-01

    Full Text Available OBJETIVOS: Avaliar se a ablação com radiofreqüência é um procedimento eficiente para o tratamento das extra-sístoles da via de saída do ventrículo direito (EVSVD, e se resulta em melhora dos sintomas. MÉTODOS: Estudo prospectivo, com 30 pacientes consecutivos (idade média de 40±13 anos, 25 do sexo feminino, sem cardiopatia estrutural aparente, com EVSVD, muito freqüentes (densidade média de 1.263±593/h, sintomáticos por mais de 1 ano (média =74 meses e refratários aos fármacos antiarrítmicos (3±1,7, incluindo os beta-bloqueadores, que foram submetidos à ablação com radiofreqüência. RESULTADOS: Após o primeiro procedimento, houve 23 sucessos iniciais (76,6% e 7 iniciais insucessos (23,4%. Quatro pacientes tiveram recorrências, sendo que dois desses não se submeteram ao segundo procedimento. O segundo procedimento foi realizado em 9 pacientes (7 insucessos iniciais e 2 recorrências, e o sucesso ocorreu em 5 pacientes adicionais, sendo 1 caso por acesso epicárdico. A taxa de sucesso final foi de 80% (24/30, e nenhuma complicação maior ocorreu. Após um seguimento médio de 14±6 meses, no grupo de sucesso final houve uma redução de mais de 90% na densidade das extra-sístoles(24/24; pOBJECTIVES: To evaluate if radiofrequency catheter ablation is an effective procedure for the treatment of right ventricular outflow tract premature ventricular contractions (RVOT-PVC and ascertain if it results in an improvement of symptoms. METHODS: A prospective study with 30 consecutive patients (mean age 40 ± 13 years, 25 females, with no apparent structural cardiopathy, with very frequent (mean density of 1,263 ± 593/h RVOT-PVC, symptomatic for more than one year (mean = 74 months and resistant to antiarrhythmic drugs (3 ± 1.7, including beta-blockers, who underwent radiofrequency catheter ablation. RESULTS: After the first procedure, there were 23 initial successful cases (76.6% and 7 initial failures (23.4%. Four patients

  17. Mediterranean Outflow Mixing and Dynamics

    Science.gov (United States)

    Price, James F.; O'Neil Baringer, Molly; Lueck, Rolf G.; Johnson, Gregory C.; Ambar, Isabel; Parrilla, Gregorio; Cantos, Alain; Kennelly, Maureen A.; Sanford, Thomas B.

    1993-02-01

    The Mediterranean Sea produces a salty, dense outflow that is strongly modified by entrainment as it first begins to descend the continental slope in the eastern Gulf of Cadiz. The current accelerates to 1.3 meters per second, which raises the internal Froude number above 1, and is intensely turbulent through its full thickness. The outflow loses about half of its density anomaly and roughly doubles its volume transport as it entrains less saline North Atlantic Central water. Within 100 kilometers downstream, the current is turned by the Coriolis force until it flows nearly parallel to topography in a damped geostrophic balance. The mixed Mediterranean outflow continues westward, slowly descending the continental slope until it becomes neutrally buoyant in the thermocline where it becomes an important water mass.

  18. Digestive tract

    International Nuclear Information System (INIS)

    Scintiscanning of salivary glands with (sup 99m)Tc is commented. The uses of triolein - and oleic acid labelled with 131I, 125I or 82Br are discussed in the study of fat absorption, as well as 14C and 191Y. The use of 57Co as a radiotracer in the intestinal absorption of vitamin B12 is analysed. Orientation is given about 51Cr - albumin clearance in the study of plasmatic protein loss by digestive tract. The radiotracers 131I, 125I and 51Cr are pointed out in the investigation of immunoglobulins. Consideration is given to the quantification of digestive bleedings by the use of 51Cr

  19. Molecular outflows in starburst nuclei

    CERN Document Server

    Roy, Arpita; Sharma, Prateek; Shchekinov, Yuri

    2016-01-01

    Recent observations have detected molecular outflows in a few nearby starburst nuclei. We discuss the physical processes at work in such an environment in order to outline a scenario that can explain the observed parameters of the phenomenon, such as the molecular mass, speed and size of the outflows. We show that outflows triggered by OB associations, with $N_{OB}\\ge 10^5$ (corresponding to a star formation rate (SFR)$\\ge 1$ M$_{\\odot}$ yr$^{-1}$ in the nuclear region), in a stratified disk with mid-plane density $n_0\\sim 200\\hbox{--}1000$ cm$^{-3}$ and scale height $z_0\\ge 200 (n_0/10^2 \\, {\\rm cm}^{-3})^{-3/5}$ pc, can form molecules in a cool dense and expanding shell. The associated molecular mass is $\\ge 10^7$ M$_\\odot$ at a distance of a few hundred pc, with a speed of several tens of km s$^{-1}$. We show that a SFR surface density of $10 \\le \\Sigma_{SFR} \\le 50$ M$_\\odot$ yr$^{-1}$ kpc$^{-2}$ favours the production of molecular outflows, consistent with observed values.

  20. Molecular outflows in starburst nuclei

    Science.gov (United States)

    Roy, Arpita; Nath, Biman B.; Sharma, Prateek; Shchekinov, Yuri

    2016-08-01

    Recent observations have detected molecular outflows in a few nearby starburst nuclei. We discuss the physical processes at work in such an environment in order to outline a scenario that can explain the observed parameters of the phenomenon, such as the molecular mass, speed and size of the outflows. We show that outflows triggered by OB associations, with NOB ≥ 105 (corresponding to a star formation rate (SFR)≥1 M⊙ yr-1 in the nuclear region), in a stratified disk with mid-plane density n0 ˜ 200-1000 cm-3 and scale height z0 ≥ 200(n0/102 cm-3)-3/5 pc, can form molecules in a cool dense and expanding shell. The associated molecular mass is ≥107 M⊙ at a distance of a few hundred pc, with a speed of several tens of km s-1. We show that a SFR surface density of 10 ≤ ΣSFR ≤ 50 M⊙ yr-1 kpc-2 favours the production of molecular outflows, consistent with observed values.

  1. Knowledge Outflows from Foreign Subsidiaries

    DEFF Research Database (Denmark)

    Perri, Alessandra; Andersson, Ulf

    This paper analyzes the MNC subsidiaries’ trade-off between the need for knowledge creation and the need for knowledge protection, and relates it to the extent of knowledge outflows generated within the host location. Combining research in International Business with Social Theory, we find that s...

  2. High Velocity Outflows in Quasars

    CERN Document Server

    Hidalgo, P R; Nestor, D; Shields, J; Hidalgo, Paola Rodriguez; Hamann, Fred; Nestor, Daniel; Shields, Joseph

    2007-01-01

    High velocity (HV) outflows are an important but poorly understood aspect of quasar/SMBH evolution. Outflows during the luminous accretion phase might play a critical role in "unveiling" young dusty AGN and regulating star formation in the host galaxies. Most quasar studies have focussed on the broad absorption lines (BALs). We are involved in a program to study a nearly unexplored realm of quasar outflow parameter space: HV winds with v>10,000 km/s up to v~0.2c but small velocity dispersions (narrow absorption lines), such that (Delta v)/v << 1. Narrow-line HV flows merit specific attention because they complement the BAL work and pose unique challenges for models of the wind acceleration, mass loss rates, launch radii, geometry, etc. We have selected the brightest quasars at 1.8outflow lines (CIV 1548 A) in existing SDSS spectra and followed up with monitoring observations to i) characterize, for the first time, the variability in a sample of absorbers spanning a ...

  3. Biopsy - biliary tract

    Science.gov (United States)

    Cytology analysis - biliary tract; Biliary tract biopsy ... A sample for a biliary tract biopsy can be obtained in different ways. A needle biopsy can be done if you have a well-defined tumor. The biopsy site ...

  4. Narrow UV Absorption Line Outflows from Quasars

    CERN Document Server

    Hamann, Fred; Hidalgo, Paola Rodriguez; Capellupo, Daniel

    2012-01-01

    Narrow absorption line (NAL) outflows are an important yet poorly understood part of the quasar outflow phenomenon. We discuss one particular NAL outflow that has high speeds, time variability, and moderate ionizations like typical BAL flows, at an estimated location just ~5 pc from the quasar. It also has a total column density and line widths (internal velocity dispersions) ~100 times smaller than BALs, with no substantial X-ray absorption. We argue that radiative shielding (in the form of an X-ray/warm absorber) is not critical for the outflow acceleration and that the moderate ionizations occur in dense substructures that have an overall small volume filling factor in the flow. We also present new estimates of the overall incidence of quasar outflow lines; e.g., ~43% of bright quasars have a C IV NAL outflow while ~68% have a C IV outflow line of any variety (NAL, BAL, or mini-BAL).

  5. CO mapping of bipolar outflows

    International Nuclear Information System (INIS)

    We present CO J =2→1 mapping of the high velocity outflow zones NGC 1333, Cep A, K3-50, S 88B, NGC 2264, and NGC 6334V, NGC 6334B, a compact region of CO emission located within a very much more extended star-forming complex. For most of these sources, the present observations represent the highest resolution mapping so far obtained, and this leads to a variety of new insights into their spatial structures and kinematics

  6. Hot Outflows in Galaxy Clusters

    CERN Document Server

    Kirkpatrick, C C

    2015-01-01

    The gas-phase metallicity distribution has been analyzed for the hot atmospheres of 29 galaxy clusters using {\\it Chandra X-ray Observatory} observations. All host brightest cluster galaxies (BCGs) with X-ray cavity systems produced by radio AGN. We find high elemental abundances projected preferentially along the cavities of 16 clusters. The metal-rich plasma was apparently lifted out of the BCGs with the rising X-ray cavities (bubbles) to altitudes between twenty and several hundred kiloparsecs. A relationship between the maximum projected altitude of the uplifted gas (the "iron radius") and jet power is found with the form $R_{\\rm Fe} \\propto P_{\\rm jet}^{0.45}$. The estimated outflow rates are typically tens of solar masses per year but exceed $100 ~\\rm M_\\odot ~yr^{-1}$ in the most powerful AGN. The outflow rates are 10% to 20% of the cooling rates, and thus alone are unable to offset a cooling inflow. Nevertheless, hot outflows effectively redistribute the cooling gas and may play a significant role at ...

  7. Lineage and morphogenetic analysis of the cardiac valves.

    Science.gov (United States)

    de Lange, Frederik J; Moorman, Antoon F M; Anderson, Robert H; Männer, Jörg; Soufan, Alexandre T; de Gier-de Vries, Corrie; Schneider, Michael D; Webb, Sandra; van den Hoff, Maurice J B; Christoffels, Vincent M

    2004-09-17

    We used a genetic lineage-labeling system to establish the material contributions of the progeny of 3 specific cell types to the cardiac valves. Thus, we labeled irreversibly the myocardial (alphaMHC-Cre+), endocardial (Tie2-Cre+), and neural crest (Wnt1-Cre+) cells during development and assessed their eventual contribution to the definitive valvar complexes. The leaflets and tendinous cords of the mitral and tricuspid valves, the atrioventricular fibrous continuity, and the leaflets of the outflow tract valves were all found to be generated from mesenchyme derived from the endocardium, with no substantial contribution from cells of the myocardial and neural crest lineages. Analysis of chicken-quail chimeras revealed absence of any substantial contribution from proepicardially derived cells. Molecular and morphogenetic analysis revealed several new aspects of atrioventricular valvar formation. Marked similarities are seen during the formation of the mural leaflets of the mitral and tricuspid valves. These leaflets form by protrusion and growth of a sheet of atrioventricular myocardium into the ventricular lumen, with subsequent formation of valvar mesenchyme on its surface rather than by delamination of lateral cushions from the ventricular myocardial wall. The myocardial layer is subsequently removed by the process of apoptosis. In contrast, the aortic leaflet of the mitral valve, the septal leaflet of the tricuspid valve, and the atrioventricular fibrous continuity between these valves develop from the mesenchyme of the inferior and superior atrioventricular cushions. The tricuspid septal leaflet then delaminates from the muscular ventricular septum late in development. PMID:15297379

  8. Worker Inflow, Outflow, and Churning

    OpenAIRE

    Ilmakunnas, Pekka; Maliranta, Mika

    2003-01-01

    Linked employer-employee data from the Finnish business sector is used in an analysis of worker turnover. The data is an unbalanced panel with over 219 000 observations in the years 1991-97. The churning (excess worker turnover), worker inflow (hiring), and worker outflow (separation) rates are explained by various plant and employee characteristics in type 2 Tobit models where the explanatory variables can have a different effect on the probability of the flow rates to be non-zero and on the...

  9. Bipolar Outflows and the Evolution of Stars

    OpenAIRE

    Frank, Adam

    1998-01-01

    Hypersonic bipolar outflows are a ubiquitous phenomena associated with both young and highly evolved stars. Observations of Planetary Nebulae, the nebulae surrounding Luminous Blue Variables such as $\\eta$ Carinae, Wolf Rayet bubbles, the circumstellar environment of SN 1987A and Young Stellar Objects all revealed high velocity outflows with a wide range of shapes. In this paper I review the current state of our theoretical understanding of these outflows. Beginning with Planetary Nebulae con...

  10. Propeller-driven Outflows and Disk Oscillations

    OpenAIRE

    Romanova, M. M.; Ustyugova, G. V.; Koldoba, A. V.; Lovelace, R. V. E.

    2005-01-01

    We report the discovery of propeller-driven outflows in axisymmetric magnetohydrodynamic simulations of disk accretion to rapidly rotating magnetized stars. Matter outflows in a wide cone and is centrifugally ejected from the inner regions of the disk. Closer to the axis there is a strong, collimated, magnetically dominated outflow of energy and angular momentum carried by the open magnetic field lines from the star. The ``efficiency'' of the propeller may be very high in the respect that mos...

  11. The role of cardiac CT angiography in the pre- and postoperative evaluation of tetralogy of Fallot

    Directory of Open Access Journals (Sweden)

    Ebrahim Banderker

    2015-10-01

    Full Text Available Tetralogy of Fallot (TOF is the first described and most common cyanotic congenital heart anomaly that generated the first successful surgical palliation procedure and definitive intracardiac repair. Classical TOF comprises the four typical features of right ventricular outflow tract obstruction (RVOTO, right ventricular hypertrophy (RVH, ventricular septal defect (VSD and aortic dextroposition. Complex forms of the condition include TOF associated with absent pulmonary valve and TOF with pulmonary atresia (TOF-PA with or without major aortopulmonary collateral arteries (MAPCAs. The pathophysiological understanding that the tetrad is basically the sequel of a singular abnormality of infundibular malformation, with anterior deviation of the infundibular septum, had major surgical consequences that improved survival. Diagnostic and functional imaging play a key role in the clinical and surgical management of patients with TOF. We revisit the role of traditionally employed imaging modalities (echocardiography and cardiac catheterisation only briefly as these remain within the domain of cardiology practice. The emphasis of the present review is to outline the role of cardiac computed tomographic angiography (CTA in the evaluation of TOF, with special reference to the technical considerations and best practice recommendations. Cardiovascular magnetic resonance imaging (CMR is addressed only in passing, as this service is not currently available at our institution.

  12. Energetic outflows from young stars

    International Nuclear Information System (INIS)

    In our galaxy, stars are born in clouds of gas, bodies so cold they do not emit any radiation at the visible wavelengths. Moreover, the clouds are permeated by cosmic dust, so that the visible radiation emitted by new stars is absorbed. Radiation at the wavelengths of infrared waves and the shortest radio waves penetrate these clouds. With the development of new telescopes and equipment for the detection of radiation at those wavelengths, astronomers are now able to explore the dark clouds where stars are born. A prime probe of the conditions within star-forming clouds has turned out to be the molecule carbon monoxide (CO). In interstellar molecular clouds, CO molecules emit radiation at a wavelength of 2.6 mm. The study of such radiation has recently revealed a new and intriguing phenomena closely associated with the birth and early evolution of stars. When certain stars are in the earliest stages of their life, they appear to be associated with violent outflows of mass. In a number of instances, molecular gas is found to be flowing outward from around newly formed stars in two supersonic streams 1800 apart. The origin and nature of these energetic outflows is a mystery. (SC)

  13. Qualitative and quantitative analyses of the morphological-dynamics of early cardiac pump action using video densidometry and optical coherence tomography (OCT)

    DEFF Research Database (Denmark)

    Männer, Jörg; Thrane, Lars; Thommes, Jan;

    2010-01-01

    During the initial phase of its pump action, vertebrate embryonic hearts are seen as valveless tubular pumps. It was traditionally thought that these tubular hearts generate unidirectional blood flow via peristalsis. Recently, however, the pumping mechanism of early embryonic hearts has become a...... matter of dispute. Uncovering of the pumping mechanism of tubular embryonic hearts requires detailed information about the hemodynamics as well as morphological dynamics of their pump action. We have therefore analyzed the morphological dynamics of cardiac pump action in chick embryos (HH-stages 16...... embryos. We have recorded striking differences in the contraction behavior (e.g. contraction speed, duration of systolic occlusion of heart lumen) of the embryonic heart segments (common atrium, AV-canal, embryonic ventricles, outflow tract). Moreover, we show, for the first time, the pump action of...

  14. Apical ballooning syndrome complicated by acute severe mitral regurgitation with left ventricular outflow obstruction – Case report

    Directory of Open Access Journals (Sweden)

    Celermajer David S

    2007-02-01

    Full Text Available Abstract Background Apical ballooning syndrome (or Takotsubo cardiomyopathy is a syndrome of transient left ventricular apical ballooning. Although first described in Japanese patients, it is now well reported in the Caucasian population. The syndrome mimicks an acute myocardial infarction but is characterised by the absence of obstructive coronary disease. We describe a serious and poorly understood complication of Takotsubo cardiomyopathy. Case Presentation We present the case of a 65 year-old lady referred to us from a rural hospital where she was treated with thrombolytic therapy for a presumed acute anterior myocardial infarction. Four hours after thrombolysis she developed acute pulmonary oedema and a new systolic murmur. It was presumed she had acute mitral regurgitation secondary to a ruptured papillary muscle, ischaemic dysfunction or an acute ventricular septal defect. Echocardiogram revealed severe mitral regurgitation, left ventricular apical ballooning, and systolic anterior motion of the mitral valve with significant left ventricular outflow tract gradient (60–70 mmHg. Coronary angiography revealed no obstructive coronary lesions. She had an intra-aortic balloon pump inserted with no improvement in her parlous haemodynamic state. We elected to replace her mitral valve to correct the outflow tract gradient and mitral regurgitation. Intra-operatively the mitral valve was mildly myxomatous but there were no structural abnormalities. She had a mechanical mitral valve replacement with a 29 mm St Jude valve. Post-operatively, her left ventricular outflow obstruction resolved and ventricular function returned to normal over the subsequent 10 days. She recovered well. Conclusion This case represents a serious and poorly understood association of Takotsubo cardiomyopathy with acute pulmonary oedema, severe mitral regurgitaton and systolic anterior motion of the mitral valve with significant left ventricular outflow tract obstruction. The

  15. Molecular Hydrogen Outflows in W51

    OpenAIRE

    Hodapp, Klaus W.; Davis, Christopher J.

    2002-01-01

    We present the results of a deep search for the molecular hydrogen shock fronts associated with young stellar outflows in the giant molecular cloud and massive star forming region W51. A total of 14 outflows were identified, and a few of these were studied in detail with high-resolution imaging and spectroscopy.

  16. Qualified Census Tracts

    Data.gov (United States)

    Department of Housing and Urban Development — A Qualified Census Tract (QCT) is any census tract (or equivalent geographic area defined by the Census Bureau) in which at least 50% of households have an income...

  17. Urinary tract infection - adults

    Science.gov (United States)

    A urinary tract infection, or UTI, is an infection of the urinary tract. The infection can occur at different points in ... al. Diagnosis, prevention, and treatment of catheter-associated ... in adults: 2009 International Clinical Practice Guidelines from ...

  18. Urinary Tract Infections (UTIs)

    Medline Plus

    Full Text Available ... Español What Other Kids Are Reading Movie: Digestive System Winter Sports: Sledding, Skiing, Snowboarding, Skating Crushes What's ... Urinary Tract? Your urinary tract is actually a system made up of these main parts: two kidneys ...

  19. [Cardiac amyloidosis. General review].

    Science.gov (United States)

    Laraki, R

    1994-04-01

    Cardiac amyloidosis, most often of AL type, is a non-exceptional disease as it represents 5 to 10% of non-ischemic cardiomyopathies. It realizes typically a restrictive cardiomyopathy. Nevertheless the wide diversity of possible presentation makes it a "big shammer" which must be evoked in front of every unexplained cardiopathy after the age of forty. If some associated manifestations can rapidly suggest the diagnosis, as a peripheric neuropathy especially a carpal tunnel syndrome or palpebral ecchymosis, cardiac involvement can also evolve in an apparently isolated way. The most suggestive paraclinic elements for the diagnosis are, in one hand, the increased myocardial echogenicity with a "granular sparkling" appearance seen throughout all walls of the left ventricle and, in the other hand, the association of a thickened left ventricle and a low voltage (electrocardiogram could also show pseudo-infarct Q waves). In front of such aspects, the proof of amyloidosis is brought by an extra-cardiac biopsy or by scintigraphy with labelled serum amyloid P component, so that the indications of endomyocardial biopsy are very limited today. The identification of the amyloid nature of a cardiopathy has an direct therapeutic implication: it contra-indicates the use of digitalis, calcium channel blockers and beta-blockers. The treatment of AL amyloidosis (chemotherapy with alkylant agents) remains very unsatisfactory especially in the cardiac involvement which is the most frequent cause of death (in AL amyloidosis). Last, cardiac amyloidosis is a bad indication for transplantation which results are burden by rapid progression of deposits especially in the gastro-intestinal tract and the nervous system. PMID:8059146

  20. Urinary Tract Infections (UTIs)

    Medline Plus

    Full Text Available ... in your urinary tract. Let's find out more. What Exactly Is a Urinary Tract? Your urinary tract is actually a system made up ... should see a doctor right away. previous continue What Will the Doctor Do? First, your doctor will ask you questions about your symptoms. ...

  1. Kidneys and Urinary Tract

    Science.gov (United States)

    ... more common kidney and urinary tract problems include: Congenital problems of the urinary tract. As a fetus develops in the womb, any part of the urinary tract can grow to an abnormal size or in an abnormal ... congenital abnormalities (meaning abnormalities that exist at birth) is ...

  2. Gene Regulatory Networks in Cardiac Conduction System Development

    OpenAIRE

    Munshi, Nikhil V.

    2012-01-01

    The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Given its critical role in coordinating cardiac performance, a detailed analysis of the molecular mechanisms underlying conduction system formation should inform our understanding of arrhythmia pathophysiology and affect the development of novel therapeutic strategies. Historically, the ability to distinguish cells of the conduction system from neighboring working myocyt...

  3. Accretion and plasma outflow from dissipationless discs

    OpenAIRE

    Bogovalov, Sergei; Kelner, Stanislav

    2008-01-01

    We consider an extreme case of disc accretion onto a gravitating centre when the viscosity in the disc is negligible. The angular momentum and the rotational energy of the accreted matter is carried out by a magnetized wind outflowing from the disc. The outflow of matter from the disc occurs due to the Blandford & Payne(1982) centrifugal mechanism. The disc is assumed to be cold. Accretion and outflow are connected by the conservation of the energy, mass and the angular momentum. The basic pr...

  4. AGN outflow feedback: Constraints from variability

    CERN Document Server

    Detmers, R G

    2009-01-01

    We present an overview on how variability can be used to constrain the location of the ionized outflow in nearby Active Galactic Nuclei using high-resolution X-ray spectroscopy. Without these constraints on the location of the outflow, the kinetic luminosity and mass loss rate can not be determined. We focus on the Seyfert 1 galaxy NGC 5548, which is arguably the best studied AGN on a timescale of 10 years. Our results show that frequent observations combined with long term monitoring, such as with the \\textit{Rossi X-ray Timing Explorer (RXTE)} satellite, are crucial to investigate the effects of these outflows on their surroundings.

  5. Outflows in Sodium Excess Objects

    CERN Document Server

    Park, Jongwon; Yi, Sukyoung K

    2015-01-01

    van Dokkum and Conroy revisited the unexpectedly strong Na I lines at 8200 A found in some giant elliptical galaxies and interpreted it as evidence for unusually bottom-heavy initial mass function. Jeong et al. later found a large population of galaxies showing equally-extraordinary Na D doublet absorption lines at 5900 A (Na D excess objects: NEOs) and showed that their origins can be different for different types of galaxies. While a Na D excess seems to be related with the interstellar medium (ISM) in late-type galaxies, smooth-looking early-type NEOs show little or no dust extinction and hence no compelling sign of ISM contributions. To further test this finding, we measured the doppler components in the Na D lines. We hypothesized that ISM would have a better (albeit not definite) chance of showing a blueshift doppler departure from the bulk of the stellar population due to outflow caused by either star formation or AGN activities. Many of the late-type NEOs clearly show blueshift in their Na D lines, wh...

  6. NK4 antagonizes Tbx1/10 to promote cardiac versus pharyngeal muscle fate in the ascidian second heart field.

    Directory of Open Access Journals (Sweden)

    Wei Wang

    2013-12-01

    Full Text Available The heart and head muscles share common developmental origins and genetic underpinnings in vertebrates, including humans. Parts of the heart and cranio-facial musculature derive from common mesodermal progenitors that express NKX2-5, ISL1, and TBX1. This ontogenetic kinship is dramatically reflected in the DiGeorge/Cardio-Velo-Facial syndrome (DGS/CVFS, where mutations of TBX1 cause malformations in the pharyngeal apparatus and cardiac outflow tract. Cardiac progenitors of the first heart field (FHF do not require TBX1 and segregate precociously from common progenitors of the second heart field (SHF and pharyngeal muscles. However, the cellular and molecular mechanisms that govern heart versus pharyngeal muscle specification within this lineage remain elusive. Here, we harness the simplicity of the ascidian larva to show that, following asymmetric cell division of common progenitors, NK4/NKX2-5 promotes GATAa/GATA4/5/6 expression and cardiac specification in the second heart precursors by antagonizing Tbx1/10-mediated inhibition of GATAa and activation of Collier/Olf/EBF (COE, the determinant of atrial siphon muscle (ASM specification. Our results uncover essential regulatory connections between the conserved cardio-pharyngeal factor Tbx1/10 and muscle determinant COE, as well as a mutual antagonism between NK4 and Tbx1/10 activities upstream of GATAa and COE. The latter cross-antagonism underlies a fundamental heart versus pharyngeal muscle fate choice that occurs in a conserved lineage of cardio-pharyngeal progenitors. We propose that this basic ontogenetic motif underlies cardiac and pharyngeal muscle development and evolution in chordates.

  7. Tetralogy of fallot (cyanotic cardiac malformation), trends and variation in a population based study

    International Nuclear Information System (INIS)

    Congenital heart diseases (CHDs) are a major threat worldwide for children below the age of five. It has high mortality and morbidity ratio. CHDs can be classified as cyanotic and acyanotic. Cyanotic cardiac malformation accounts 25% of all congenital heart diseases and Tetralogy of Fallot (TOF) is .the most common form of cyanotic CHD. Tetralogy of Fallot is a combination of four anatomical abnormalities. These include a large ventricular septal defect (VSD), right ventricular outflow tract and pulmonary valve obstruction, right ventricular hypertrophy, and over-riding of the aorta. The current investigation was conducted over the span of 2.5 years on the patients presented in OPD and hospitalized at various pediatric cardiology centers. A detailed family history was taken to elucidate the genetic and environmental factors. Diagnosis was confirmed by the cardiologist based on examination of cardiac murmur, chest X-ray, fetal echocardiography (ECG), complete blood count (CBC), echocardiograms and/or echocardiogram (ECHO) reports, cardiac catherization reports, operative notes and MRI of heart, if applicable. This study recruited a cohort of 268 patients and 140 controls, healthy unrelated individuals. The mean age for patients was 2.97+-1.21 and that for controls was 3.14+-2.44 years. Males were shown to have a higher rate of incidence than females (1.26:1) in our population. The genes that are mainly involved are NKX 2.5, GAT A 4, TBX5, JAGI, ZFPM2 and VEGF. The present study focuses on NKX 2.5 and its mutations in our population. (author)

  8. Disk-Driven Outflows in AGNs

    CERN Document Server

    Koenigl, A

    2003-01-01

    Analysis of spectral absorption features has led to the identification of several distinct outflow components in AGNs. The outflowing gas is evidently photoionized by the nuclear continuum source and originates in the accretion flow toward the central black hole. The most likely driving mechanisms are continuum and line radiation pressure and magnetic stresses. The theoretical modeling of these outflows involves such issues as: (1) Which of the above mechanisms actually contributes in each case? (2) How is the gas uplifted from the underlying accretion disk? (3) How can the intense central continuum radiation be shielded to allow efficient radiative driving? (4) Is the outflow continuous or clumpy, and, if clumpy, what is the nature and dynamical state of the ``clouds''? This review summarizes recent theoretical and observational results that bear on these questions and outlines prospects for further progress.

  9. Magnetosphere sawtooth oscillations induced by ionospheric outflow.

    Science.gov (United States)

    Brambles, O J; Lotko, W; Zhang, B; Wiltberger, M; Lyon, J; Strangeway, R J

    2011-06-01

    The sawtooth mode of convection of Earth's magnetosphere is a 2- to 4-hour planetary-scale oscillation powered by the solar wind-magnetosphere-ionosphere (SW-M-I) interaction. Using global simulations of geospace, we have shown that ionospheric O(+) outflows can generate sawtooth oscillations. As the outflowing ions fill the inner magnetosphere, their pressure distends the nightside magnetic field. When the outflow fluence exceeds a threshold, magnetic field tension cannot confine the accumulating fluid; an O(+)-rich plasmoid is ejected, and the field dipolarizes. Below the threshold, the magnetosphere undergoes quasi-steady convection. Repetition and the sawtooth period are controlled by the strength of the SW-M-I interaction, which regulates the outflow fluence. PMID:21636770

  10. Cardiac rehabilitation

    Science.gov (United States)

    ... attack or other heart problem. You might consider cardiac rehab if you have had: Heart attack Coronary heart disease (CHD) Heart failure Angina (chest pain) Heart or heart valve surgery Heart transplant Procedures such as angioplasty and stenting In some ...

  11. Cardiac Rehabilitation

    Science.gov (United States)

    Cardiac rehabilitation (rehab) is a medically supervised program to help people who have A heart attack Angioplasty or coronary artery bypass grafting for coronary heart disease A heart valve repair or replacement A ...

  12. Cardiac sarcoidosis

    OpenAIRE

    Costello BT; Nadel J.; Taylor AJ

    2016-01-01

    Benedict T Costello,1,2 James Nadel,3 Andrew J Taylor,1,21Department of Cardiovascular Medicine, The Alfred Hospital, 2Baker IDI Heart and Diabetes Research Institute, Melbourne, VIC, 3School of Medicine, University of Notre Dame, Sydney, NSW, Australia Abstract: Cardiac sarcoidosis is a rare but life-threatening condition, requiring a high degree of clinical suspicion and low threshold for investigation to make the diagnosis. The cardiac manifestations include heart failure, conducting syst...

  13. Procedimento de Lecompte para a correção de transposição das grandes artérias, associada à comunicação interventricular e obstrução de via de saída do ventrículo esquerdo Lecompte procedure for correction of the transposition of the great arteries associated with ventricular septal defect and left ventricle outflow tract obstruction

    Directory of Open Access Journals (Sweden)

    Miguel Angel Maluf

    2006-12-01

    Full Text Available OBJETIVO: Avaliar o procedimento de Lecompte para a correção da transposição das grandes artérias associada à comunicação interventricular e obstrução da via de saída do ventrículo esquerdo (TGA, CIV e OVSVE e apresentar os resultados no período pós-operatório intermediário e tardio. MÉTODO: Entre fevereiro de 1994 e julho de 2005, sete pacientes, com idade de 2 a 8 anos (mediana -M-: 3,0, portadores de TGA, CIV e OVSVE, foram submetidos a tratamento cirúrgico corretivo. Em seis casos, foi utilizado o procedimento de Lecompte. Esta técnica consiste na abordagem por ventriculotomia direita, ressecção ampla do septo conal e construção de um túnel ventricular conectando o ventrículo esquerdo à aorta; o caso restante apresentava obstrução da prótese valvulada implantada entre o ventrículo direito e a artéria pulmonar (VD-AP e falência do VD e foi submetido à conversão no procedimento de Lecompte. RESULTADOS: Os tempos de CEC variaram entre 105 e 194 min (M: 130 e os tempos de anoxia entre 65 e 90 min (M: 78. Houve um óbito no pós-operatório imediato devido a coagulopatia, seguido de insuficiência ventricular direita. Os seis pacientes sobreviventes receberam alta hospitalar no período de 5 a 30 dias (M: 11 e permaneceram em acompanhamento entre 12 a 144 meses (M: 73,6. CONCLUSÃO: O procedimento de Lecompte teve como vantagens: 1 - Indicação cirúrgica em pacientes com menor faixa etária; 2 - Baixa morbi-mortalidade; 3 - Expectativa de acompanhamento a longo prazo, sem reoperação; 4 - Possibilidade de converter o procedimento de Rastelli em Lecompte.OBJECTIVE: To evaluate the Lecompte procedure used for the correction of transposition of the great arteries (TGA associated with ventricular septal defect (VSD and left ventricle outflow tract obstruction (LVOTO and to present the intermediate and long-term results of the surgery. METHODS: Between February 1994 and July 2005, seven patients with ages between 2

  14. Molecular Outflows From the Protocluster, Serpens South

    CERN Document Server

    Nakamura, Fumitaka; Shimajiri, Yoshito; Tsukagoshi, Takashi; Higuchi, Aya E; Nishiyama, Shogo; Kawabe, Ryohei; Takami, Michihiro; Karr, Jennifer L; Gutermuth, Robert A; Wilson, Grant

    2011-01-01

    We present the results of CO ($J=3-2$) and HCO$^+$ ($J=4-3$) mapping observations toward a nearby embedded cluster, Serpens South, using the ASTE 10 m telescope. Our CO ($J=3-2$) map reveals that many outflows are crowded in the dense cluster-forming clump that can be recognized as a HCO$^+$ clump with a size of $\\sim$ 0.2 pc and mass of $\\sim$ 80 M$_\\odot$. The clump contains several subfragments with sizes of $\\sim$ 0.05 pc. By comparing the CO ($J=3-2$) map with the 1.1 mm dust continuum image taken by AzTEC on ASTE, we find that the spatial extents of the outflow lobes are sometimes anti-correlated with the distribution of the dense gas and some of the outflow lobes apparently collide with the dense gas. The total outflow mass, momentum, and energy are estimated at 0.6 $M_\\odot$, 8 $M_\\odot$ km s$^{-1}$, and 64 $M_\\odot$ km$^2$ s$^{-2}$, respectively. The energy injection rate due to the outflows is comparable to the turbulence dissipation rate in the clump, implying that the protostellar outflows can mai...

  15. Urinary Tract Imaging

    OpenAIRE

    Rowley, V. Allen

    1986-01-01

    This article reviews the current imaging investigations usually required in the work-up of common urinary tract problems such as urinary tract infection, colic, trauma, hematuria and renal failure. Radiological therapeutic techniques such as percutaneous nephrostomy for drainage of obstructed systems and percutaneous nephrolithotomy for treatment of renal calculi are briefly mentioned. The virtual elimination of percutaneous or open surgery for renal and upper urinary tract stones, resulting ...

  16. A Robust Measurement of the Mass Outflow Rate of the Galactic Outflow from NGC 6090

    Science.gov (United States)

    Chisholm, John; Tremonti, Christy A.; Leitherer, Claus; Chen, Yanmei

    2016-08-01

    To evaluate the impact of stellar feedback, it is critical to estimate the mass outflow rates of galaxies. Past estimates have been plagued by uncertain assumptions about the outflow geometry, metallicity, and ionization fraction. Here we use Hubble Space Telescope ultraviolet spectroscopic observations of the nearby starburst NGC 6090 to demonstrate that many of these quantities can be constrained by the data. We use the Si IV absorption lines to calculate the scaling of velocity (v), covering fraction (Cf), and density with distance from the starburst (r), assuming the Sobolev optical depth and a velocity law of the form: v~∝(1 - Ri/r)β (where Ri is the inner outflow radius). We find that the velocity (β=0.43) is consistent with an outflow driven by an r-2 force with the outflow radially accelerated, while the scaling of the covering fraction (Cf∝r-0.82) suggests that cool clouds in the outflow are in pressure equilibrium with an adiabatically expanding medium. We use the column densities of four weak metal lines and CLOUDY photoionization models to determine the outflow metallicity, the ionization correction, and the initial density of the outflow. Combining these values with the profile fitting, we find Ri = 63 pc, with most of the mass within 300 pc of the starburst. Finally, we find that the maximum mass outflow rate is 2.3 M⊙ yr-1 and the mass loading factor (outflow divided by the star formation rate) is 0.09, a factor of 10 lower than the value calculated using common assumptions for the geometry, metallicity and ionization structure of the outflow.

  17. Optimization of the Outflow Graft Position and Angle in a Left Ventricular Assist Device

    Science.gov (United States)

    McGah, Patrick; Prisco, Anthony; Beckman, Jennifer; Mokadam, Nahush; Mahr, Claudius; Aliseda, Alberto

    2015-11-01

    The placement of the outflow graft in the aorta plays a key role in the hemodynamics of Left Ventricle Assist Devices (LVAD), a medical device with a growing importance in the treatment of end-stage heart failure. We use a patient-specific computational model of the VAD and the ascending aorta to investigate the impact of VAD outflow graft configuration on the residence time and wall shear stresses along the ascending aorta and the ostia of the upper branches. The flow induced by the combination of VAD output through the graft anastomosed to the aorta and the limited cardiac output through intermittent opening of the aortic valve is studied to determine the nature of thrombogenic flow patterns. Outflow grafts are virtually anastomosed along the ascending aorta or subclavian artery of the patient-specific model at different positions and angles that are surgically-informed. Detailed markers of thrombosis, such as cell residence time, wall shear stress, and shear stress gradients are analyzed and compared for the different configurations. The angle of incidence of the outflow graft critically influences the volume of recirculating flow between aortic valve and anastomosis, and the aortic pressure acting against aortic valve opening.

  18. Urinary Tract Infections

    Science.gov (United States)

    ... can usually be found and treated before the kidneys become infected. If your doctor treats a urinary tract infection early and ... Tips on preventing urinary tract infections Drink plenty of water to flush out bacteria. Drinking cranberry juice may also help ...

  19. Urinary Tract Infections (UTIs)

    Medline Plus

    Full Text Available ... Dictionary of Medical Words En Español What Other Kids Are Reading Movie: Digestive System Winter Sports: Sledding, ... a Booger? Urinary Tract Infections (UTIs) KidsHealth > For Kids > Urinary Tract Infections (UTIs) Print A A A ...

  20. Cardiac CT

    Energy Technology Data Exchange (ETDEWEB)

    Dewey, Marc [Charite - Universitaetsmedizin Berlin (Germany). Inst. fuer Radiologie

    2011-07-01

    Computed tomography of the heart has become a highly accurate diagnostic modality that is attracting increasing attention. This extensively illustrated book aims to assist the reader in integrating cardiac CT into daily clinical practice, while also reviewing its current technical status and applications. Clear guidance is provided on the performance and interpretation of imaging using the latest technology, which offers greater coverage, better spatial resolution, and faster imaging. The specific features of scanners from all four main vendors, including those that have only recently become available, are presented. Among the wide range of applications and issues to be discussed are coronary artery bypass grafts, stents, plaques, and anomalies, cardiac valves, congenital and acquired heart disease, and radiation exposure. Upcoming clinical uses of cardiac CT, such as plaque imaging and functional assessment, are also explored. (orig.)

  1. Cardiac echinococcosis

    Directory of Open Access Journals (Sweden)

    Ivanović-Krstić Branislava A.

    2002-01-01

    Full Text Available Cardiac hydatid disease is rare. We report on an uncommon hydatid cyst localized in the right ventricular wall, right atrial wall tricuspid valve left atrium and pericard. A 33-year-old woman was treated for cough, fever and chest pain. Cardiac echocardiograpic examination revealed a round tumor (5.8 x 4 cm in the right ventricular free wall and two smaller cysts behind that tumor. There were cysts in right atrial wall and tricuspidal valve as well. Serologic tests for hydatidosis were positive. Computed tomography finding was consistent with diagnosis of hydatid cyst in lungs and right hylar part. Surgical treatment was rejected due to great risk of cardiac perforation. Medical treatment with albendazole was unsuccessful and the patient died due to systemic hydatid involvement of the lungs, liver and central nervous system.

  2. Evolution of Mass Outflow in Protostars

    CERN Document Server

    Watson, Dan M; Fischer, William J; Forrest, W J; Manoj, P; Megeath, S Thomas; Melnick, Gary J; Najita, Joan; Neufeld, David A; Sheehan, Patrick D; Stutz, Amelia M; Tobin, John J

    2015-01-01

    We have surveyed 84 Class 0, Class I, and flat-spectrum protostars in mid-infrared [Si II], [Fe II] and [S I] line emission, and 11 of these in far-infrared [O I] emission. We use the results to derive their mass outflow rates. Thereby we observe a strong correlation of mass outflow rates with bolometric luminosity, and with the inferred mass accretion rates of the central objects, which continues through the Class 0 range the trend observed in Class II young stellar objects. Along this trend from large to small mass-flow rates, the different classes of young stellar objects lie in the sequence Class 0 -- Class I/flat-spectrum -- Class II, indicating that the trend is an evolutionary sequence in which mass outflow and accretion rates decrease together with increasing age, while maintaining rough proportionality. The survey results include two which are key tests of magnetocentrifugal outflow-acceleration mechanisms: the distribution of the outflow/accretion branching ratio b, and limits on the distribution of...

  3. Bursty star formation feedback and cooling outflows

    CERN Document Server

    Suarez, Teresita; Peiris, Hiranya V; Slyz, Adrianne; Devriendt, Julien

    2016-01-01

    We study how outflows of gas launched from a central galaxy undergoing repeated starbursts propagate through the circumgalactic medium (CGM), using the simulation code RAMSES. We assume that the outflow from the disk can be modelled as a rapidly moving bubble of hot gas at $\\mathrm{\\sim1\\;kpc}$ above disk, then ask what happens as it moves out further into the halo around the galaxy on $\\mathrm{\\sim 100\\;kpc}$ scales. To do this we run 60 two-dimensional simulations scanning over parameters of the outflow. Each of these is repeated with and without radiative cooling, assuming a primordial gas composition to give a lower bound on the importance of cooling. In a large fraction of radiative-cooling cases we are able to form rapidly outflowing cool gas from in situ cooling of the flow. We show that the amount of cool gas formed depends strongly on the 'burstiness' of energy injection; sharper, stronger bursts typically lead to a larger fraction of cool gas forming in the outflow. The abundance ratio of ions in th...

  4. Interventional management of hepatic venous outflow obstruction after liver transplantation

    International Nuclear Information System (INIS)

    Objective: To discuss the technique and efficacy of interventional management for the treatment of hepatic venous outflow obstruction (HVO) after liver transplantation. Methods: The clinical data of 5 patients with HVO developed after liver transplantation, including split (n=2) and living donor (n =3) liver transplantation, were retrospectively analyzed. Stent placement was performed in 4 cases and percutaneous transluminal angioplasty in one case. The technical points of interventional management were discussed. Results: Interventional management was performed via the percutaneous hepatic vein approach in 3 patients and via the right internal jugular venous access in 2 patients. Judged from hepatic venography, the location of HVO was at the anastomotic stoma of left- or right-hepatic vein with inferior vena cava (n=3 ) or at the anastomotic stoma of middle hepatic vein with right hepatic vein (n=2). Interventional technical success was achieved in all 5 patients. After the procedure, the venous pressure gradient, i.e. the blood pressure difference between the hepatic artery and the right atrium, was significantly reduced from (15.4 ± 5.6)mmHg to(1.9 ±1.2) mmHg. During the follow-up period of 9-482 days, no restenosis was found on Doppler sonographic manifestations. The liver enzyme and/or bilirubin which were markedly elevated before procedure returned to normal after the procedure in 4 patients except one patient who died of multiple-organs failure at the 9th day after the treatment. In two patients with large quantity of ascites and upper digestive tract bleeding, the ascites receded and the bleeding stopped after the procedure. Conclusion: Hepatic venous outflow obstruction is a rare, but potentially fatal, complication after liver transplantation and interventional management with stent placement or percutaneous transluminal angioplasty is an effective and safe treatment for it. (authors)

  5. Cardiac sarcoidosis

    Science.gov (United States)

    Smedema, J.P.; Zondervan, P.E.; van Hagen, P.; ten Cate, F.J.; Bresser, P.; Doubell, A.F.; Pattynama, P.; Hoogsteden, H.C.; Balk, A.H.M.M.

    2002-01-01

    Sarcoidosis is a multi-system granulomatous disorder of unknown aetiology. Symptomatic cardiac involvement occurs in approximately 5% of patients. The prevalence of sarcoidosis in the Netherlands is unknown, but estimated to be approximately 20 per 100,000 population (3200 patients). We report on five patients who presented with different manifestations of cardiac sarcoidosis, and give a brief review on the current management of this condition. Magnetic Resonance Imaging (MRI) can be of great help in diagnosing this condition as well as in the follow-up of the response to therapy. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5Figure 6 PMID:25696121

  6. Observations of Protostellar Outflow Feedback in Clustered Star Formation

    CERN Document Server

    Nakamura, Fumitaka

    2015-01-01

    We discuss the role of protostellar outflow feedback in clustered star formation using the observational data of recent molecular outflow surveys toward nearby cluster-forming clumps. We found that for almost all clumps, the outflow momentum injection rate is significantly larger than the turbulence dissipation rate. Therefore, the outflow feedback is likely to maintain supersonic turbulence in the clumps. For less massive clumps such as B59, L1551, and L1641N, the outflow kinetic energy is comparable to the clump gravitational energy. In such clumps, the outflow feedback probably affects significantly the clump dynamics. On the other hand, for clumps with masses larger than about 200 M$_\\odot$, the outflow kinetic energy is significantly smaller than the clump gravitational energy. Since the majority of stars form in such clumps, we conclude that outflow feedback cannot destroy the whole parent clump. These characteristics of the outflow feedback support the scenario of slow star formation.

  7. Zooplankton in the Arctic outflow

    Science.gov (United States)

    Soloviev, K. A.; Dritz, A. V.; Nikishina, A. B.

    2009-04-01

    Climate changes in the Arctic cause the changes in the current system that may have cascading effect on the structure of plankton community and consequently on the interlinked and delicately balanced food web. Zooplankton species are by definition incapable to perform horizontal moving. Their transport is connected with flowing water. There are zooplankton species specific for the definite water masses and they can be used as markers for the different currents. That allows us to consider zooplankton community composition as a result of water mixing in the studied area. Little is known however about the mechanisms by which spatial and temporal variability in advection affect dynamics of local populations. Ice conditions are also very important in the function of pelagic communities. Melting time is the trigger to all "plankton blooming" processes, and the duration of ice-free conditions determines the food web development in the future. Fram Strait is one of the key regions for the Arctic: the cold water outflow comes through it with the East Greenland Current and meets warm Atlantic water, the West Spitsbergen Current, producing complicated hydrological situation. During 2007 and 2008 we investigated the structure functional characteristics of zooplankton community in the Fram Strait region onboard KV "Svalbard" (April 2007, April and May 2008) and RV "Jan Mayen" (May 2007, August 2008). This study was conducted in frame of iAOOS Norway project "Closing the loop", which, in turn, was a part of IPY. During this cruises multidisciplinary investigations were performed, including sea-ice observations, CTD and ADCP profiling, carbon flux, nutrients and primary production measurements, phytoplankton sampling. Zooplankton was collected with the Hydro-Bios WP2 net and MultiNet Zooplankton Sampler, (mouth area 0.25 m2, mesh size 180 um).Samples were taken from the depth strata of 2000-1500, 1500-1000, 1000-500,500-200, 200-100, 100-60, 60-30, 30-0 m. Gut fluorescence

  8. Outflows in Regions of Star Formation

    CERN Document Server

    Liseau, R

    2004-01-01

    The high spatial and spectral resolution offered by the new generation of infrared spectrometers at ESO is optimally suited for the observational study of outflows from young stellar objects. Models of interstellar shock waves would benefit from observations of spectrally resolved line profiles. This applies also to attempts of measuring the rotation rates of jets very close to their driving source, which in general suffer considerable extinction. Observations of forbidden lines of ionised iron, [Fe II], could be used to accomplish this. The possibility of using rotational lines of molecular hydrogen, H2, to study the temporal evolution of outflow and disk gas is discussed. Similarly, high resolution IR observations of fluorescent water lines, H2O, open up the possibility to access outflow and disk water.

  9. Wind influence on a coastal buoyant outflow

    Science.gov (United States)

    Whitney, Michael M.; Garvine, Richard W.

    2005-03-01

    This paper investigates the interplay between river discharge and winds in forcing coastal buoyant outflows. During light winds a plume influenced by the Earth's rotation will flow down shelf (in the direction of Kelvin wave propagation) as a slender buoyancy-driven coastal current. Downwelling favorable winds augment this down-shelf flow, narrow the plume, and mix the water column. Upwelling favorable winds drive currents that counter the buoyancy-driven flow, spread plume waters offshore, and rapidly mix buoyant waters. Two criteria are developed to assess the wind influence on a buoyant outflow. The wind strength index (Ws) determines whether a plume's along-shelf flow is in a wind-driven or buoyancy-driven state. Ws is the ratio of the wind-driven and buoyancy-driven along-shelf velocities. Wind influence on across-shelf plume structure is rated with a timescale (ttilt) for the isopycnal tilting caused by wind-driven Ekman circulation. These criteria are used to characterize wind influence on the Delaware Coastal Current and can be applied to other coastal buoyant outflows. The Delaware buoyant outflow is simulated for springtime high-river discharge conditions. Simulation results and Ws values reveal that the coastal current is buoyancy-driven most of the time (∣Ws∣ 1) several times during the high-discharge period. Strong upwelling events reverse the buoyant outflow; they constitute an important mechanism for transporting fresh water up shelf. Across-shelf plume structure is more sensitive to wind influence than the along-shelf flow. Values of ttilt indicate that moderate or strong winds persisting throughout a day can modify plume width significantly. Plume widening during upwelling events is accompanied by mixing that can erase the buoyant outflow.

  10. Cardiac Pacemakers

    International Nuclear Information System (INIS)

    A complete survey of physiological biophysical,clinical and engineering aspects of cardiac facing,including the history and an assessment of possible future developments.Among the topics studied are: pacemakers, energy search, heart stimulating with pacemakers ,mathematical aspects of the electric cardio stimulation chronic, pacemaker implants,proceeding,treatment and control

  11. Episodic High Velocity Outflows from V899 Mon: A Constraint On The Outflow Mechanisms

    CERN Document Server

    Ninan, J P; Philip, N S

    2016-01-01

    We report the detection of large variations in the outflow wind velocity from a young eruptive star, V899 Mon during its ongoing high accretion outburst phase. Such large variations in the outflow velocity (from -722 km s$^{-1}$ to -425 km s$^{-1}$) have never been reported previously in this family of objects. Our continuous monitoring of this source shows that the multi-component, clumpy, and episodic high velocity outflows are stable in the time scale of a few days, and vary over the time scale of a few weeks to months. We detect significant decoupling in the instantaneous outflow strength to accretion rate. From the comparison of various possible outflow mechanisms in magnetospheric accretion of young stellar objects, we conclude magnetically driven polar winds to be the most consistent mechanism for the outflows seen in V899 Mon. The large scale fluctuations in outflow over the short period makes V899 Mon the most ideal source to constrain various magnetohydrodynamics (MHD) simulations of magnetospheric ...

  12. Episodic High-velocity Outflows from V899 Mon: A Constraint On The Outflow Mechanisms

    Science.gov (United States)

    Ninan, J. P.; Ojha, D. K.; Philip, N. S.

    2016-07-01

    We report the detection of large variations in the outflow wind velocity from a young eruptive star, V899 Mon, during its ongoing high accretion outburst phase. Such large variations in the outflow velocity (from ‑722 to ‑425 km s‑1) have never been reported previously in this family of objects. Our continuous monitoring of this source shows that the multi-component, clumpy, and episodic high velocity outflows are stable in the timescale of a few days, and vary over the timescale of a few weeks to months. We detect significant decoupling in the instantaneous outflow strength to accretion rate. From the comparison of various possible outflow mechanisms in magnetospheric accretion of young stellar objects, we conclude magnetically driven polar winds to be the most consistent mechanism for the outflows seen in V899 Mon. The large scale fluctuations in outflow over the short period makes V899 Mon the most ideal source to constrain various magnetohydrodynamics simulations of magnetospheric accretion. Based on observations made with the Southern African Large Telescope (SALT).

  13. Clinical Assessment of Intraventricular Blood Transport in Patients Undergoing Cardiac Resynchronization Therapy

    Science.gov (United States)

    Rossini, Lorenzo; Martinez-Legazpi, P.; Benito, Y.; Perez Del Villar, C.; Gonzalez-Mansilla, A.; Barrio, A.; Yotti, R.; Kahn, A. M.; Shadden, S. C.; Fernandez-Aviles, F.; Bermejo, J.; Del Alamo, J. C.

    2015-11-01

    In the healthy heart, left ventricular (LV) filling generates flow patterns which have been proposed to optimize blood transport by coupling diastole and systole phases. We present a novel image-based method to assess how flow patterns influence LV blood transport in patients undergoing cardiac resynchronization therapy (CRT). Solving the advection equation with time-varying inflow boundary conditions allows to track the transport of blood entering the LV in the different filling waves, as well as the transport barriers which couple filling and ejection. The velocity fields were obtained using echocardiographic color Doppler velocimetry, which provides two-dimensional time-resolved flow maps in the apical long axis three-chamber view of the LV. We analyze flow transport in a group of patients with CRT devices as well as in healthy volunteers. In the patients under CRT, the device programming was varied to analyze flow transport under different values of the atrioventricular (AV) conduction delay and to model tachycardia. This analysis illustrates how CRT influences the transit of blood inside the LV, contributes to conserving kinetic energy and favors the generation of hemodynamic forces that accelerate blood in the direction of the LV outflow tract.

  14. Urinary Tract Infections (UTIs)

    Medline Plus

    Full Text Available ... Urinary Tract Troubles Girls are more likely than boys to get a UTI. That's because their urethras are much shorter than boys' urethras. The shorter urethra means bacteria can get ...

  15. Pediatric Urinary Tract Infection

    Science.gov (United States)

    SBA National Resource Center: 800-621-3141 Pediatric Urinary Tract Infections and Catheterization in Children with Neurogenic Bladder and Bowel Why is it important to begin urologic care in infancy and ...

  16. Urinary Tract Infections (UTIs)

    Medline Plus

    Full Text Available ... when you do, phew! Your pee smells bad. These changes occur because bacteria have caused an infection ... tract is actually a system made up of these main parts: two kidneys two ureters (say: yur - ...

  17. Urinary Tract Infections (UTIs)

    Medline Plus

    Full Text Available ... Problems of Grown Ups People, Places & Things That Help Feelings Q&A Movies & More Quizzes Kids' Dictionary ... ll never want to have one again! To help keep those bacteria out of your urinary tract, ...

  18. Acute Urinary Tract Obstruction

    Directory of Open Access Journals (Sweden)

    Aleksic Djordje

    2015-09-01

    Full Text Available The kidneys are paired organs with the primary function of helping to remove toxins from the body and regulate water balance. They are vital to survival. After urine is produced in the kidneys, it must pass into the bladder, where it can be stored before being eliminated from the body through the urethra. Urinary tract obstruction is a common problem encountered by urologists, primary care physicians, and emergency medicine physicians. Urine can become obstructed at any point in this pathway. There are three groups of urinary tract obstructions: 1 obstruction of the urinary tract lumen; 2 obstruction of the urinary tract wall; and 3 extrinsic obstruction, which can press on the urinary tract lumen. An obstruction can be present from birth or develop later in life. The most common causes of obstruction include stones, strictures, tumours, and bladder dysfunction. These obstructions may result in the hydronephrosis of one or both kidneys, which, if left untreated, may lead to the deterioration of renal function. The goal of an initial treatment of urinary tract obstruction is to remove the obstruction. Later, we treat the cause that led to the obstruction. The bottom line is that all efforts should be made to preserve kidney function to avoid the need for dialysis or renal transplantation.

  19. [Urinary tract infections].

    Science.gov (United States)

    Hörl, W H

    2011-09-01

    Urinary tract infections occur very frequently in the community and in hospitalized patients and are mainly caused by Escherichia (E.) coli. Depending on virulence determinants of uropathogenic microorganisms and host-specific defense mechanisms, urinary tract infections can manifest as cystitis, pyelonephritis (bacterial interstitial nephritis), bacteremia or urosepsis. Uncomplicated urinary tract infections in otherwise healthy women should be treated for 3-7 days depending on the antibiotic therapy chosen, even if spontaneous remission rates of up to 40% have been reported. Antibiotics of the first choice for empirical treatment of uncomplicated urinary tract infection are fluoroquinolones, pivmecillinam and fosfomycin. A huge problem is the increasing antimicrobial resistance of uropathogenic microorganisms. Complicated urinary tract infections associated with anatomical and/or functional abnormalities of the urinary tract and/or comorbidities such as diabetes or immunosuppressive therapy, need longer antibiotic treatment (e.g. 10-14 days) as well as interdisciplinary diagnostic procedures. Treatment of community acquired urosepsis includes cephalosporins of the third generation, piperacillin/tazobactam or ciprofloxacin. For nosocomial urosepsis the combination with an aminoglycoside or a carbapenem is recommended. PMID:21850538

  20. Accretion, Outflows, and Winds of Magnetized Stars

    CERN Document Server

    Romanova, M M

    2016-01-01

    Many types of stars have strong magnetic fields that can dynamically influence the flow of circumstellar matter. In stars with accretion disks, the stellar magnetic field can truncate the inner disk and determine the paths that matter can take to flow onto the star. These paths are different in stars with different magnetospheres and periods of rotation. External field lines of the magnetosphere may inflate and produce favorable conditions for outflows from the disk-magnetosphere boundary. Outflows can be particularly strong in the propeller regime, wherein a star rotates more rapidly than the inner disk. Outflows may also form at the disk-magnetosphere boundary of slowly rotating stars, if the magnetosphere is compressed by the accreting matter. In isolated, strongly magnetized stars, the magnetic field can influence formation and/or propagation of stellar wind outflows. Winds from low-mass, solar-type stars may be either thermally or magnetically driven, while winds from massive, luminous O and B type stars...

  1. Propeller-driven Outflows and Disk Oscillations

    CERN Document Server

    Romanova, M M; Koldoba, A V; Lovelace, R V E

    2005-01-01

    We report the discovery of propeller-driven outflows in axisymmetric magnetohydrodynamic simulations of disk accretion to rapidly rotating magnetized stars. Matter outflows in a wide cone and is centrifugally ejected from the inner regions of the disk. Closer to the axis there is a strong, collimated, magnetically dominated outflow of energy and angular momentum carried by the open magnetic field lines from the star. The ``efficiency'' of the propeller may be very high in the respect that most of the incoming disk matter is expelled from the system in winds. The star spins-down rapidly due to the magnetic interaction with the disk through closed field lines and with corona through open field lines. Diffusive and viscous interaction between magnetosphere and the disk are important: no outflows were observed for very small values of the diffusivity and viscosity. These simulation results are applicable to the early stages of evolution of classical T Tauri stars and to different stages of evolution of cataclysmi...

  2. Left ventricular outflow obstruction and necrotizing enterocolitis

    Energy Technology Data Exchange (ETDEWEB)

    Allen, H.A.; Haney, P.J.

    1984-02-01

    Two neonates had unusually rapid development of necrotizing enterocolitis within 24 hours of birth. Both patients had decreased systemic perfusion secondary to aortic atresia. Onset of either clinical or radiographic manifestations of necrotizing enterocolitis in the first day of life should alert one to the possible presence of severe left ventricular outflow obstruction.

  3. The Resolved Outflow from 3C 48

    Science.gov (United States)

    Shih, Hsin-Yi; Stockton, Alan

    2014-10-01

    We investigate the properties of the high-velocity outflow driven by the young radio jet of 3C 48, a compact-steep-spectrum source. We use the Space Telescope Imaging Spectrograph on board the Hubble Space Telecope to obtain (1) low-resolution UV and optical spectra and (2) multi-slit medium-resolution spectra of the ionized outflow. With supporting data from ground-based spectrographs, we are able to accurately measure the ratios of diagnostic emission lines such as [O III] λ5007, [O III] λ3727, [N II] λ6548, Hα, Hβ, [Ne V] λ3425, and [Ne III] λ3869. We fit the observed emission-line ratios using a range of ionization models, powered by active galactic nucleus (AGN) radiation and shocks, produced by the MAPPINGS code. We have determined that AGN radiation is likely the dominant ionization source. The outflow's density is estimated to be in the range n = 103-104 cm-3, the mass is ~6 × 106 M ⊙, and the metallicity is likely equal to or higher than solar. Compared with the typical outflows associated with more evolved radio jets, this young outflow is denser, less massive, and more metal rich. Multi-slit observations allow us to construct a two-dimensional velocity map of the outflow that shows a wide range of velocities with distinct velocity components, suggesting a wide-angle clumpy outflow. Based in part on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with program GO-11574. Some of the data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. Some of the

  4. Cardiac rhabdomyosarcoma

    OpenAIRE

    Chlumský, Jaromír; Holá, Dana; Hlaváček, Karel; Michal, Michal; Švec, Alexander; Špatenka, Jaroslav; Dušek, Jan

    2001-01-01

    Cardiac sarcoma is a very rare neoplasm and is difficult to diagnose. The case of a 51-year-old man with a left atrial tumour, locally recurrent three months after its surgical removal, is presented. Computed tomography showed metastatic spread to the lung parenchyma. On revised histology, the mass extirpated was a sarcoma. Because of the metastatic spread, further therapy was symptomatic only; the patient died 15 months after the first manifestation of his problems. Immunohistochemical stain...

  5. Cardiac Calcification

    Directory of Open Access Journals (Sweden)

    Morteza Joorabian

    2011-05-01

    Full Text Available There is a spectrum of different types of cardiac"ncalcifications with the importance and significance"nof each type of cardiac calcification, especially"ncoronary artery calcification. Radiologic detection of"ncalcifications within the heart is quite common. The"namount of coronary artery calcification correlates"nwith the severity of coronary artery disease (CAD."nCalcification of the aortic or mitral valve may indicate"nhemodynamically significant valvular stenosis."nMyocardial calcification is a sign of prior infarction,"nwhile pericardial calcification is strongly associated"nwith constrictive pericarditis. A spectrum of different"ntypes of cardiac calcifications (linear, annular,"ncurvilinear,... could be seen in chest radiography and"nother imaging modalities. So a carful inspection for"ndetection and reorganization of these calcifications"nshould be necessary. Numerous modalities exist for"nidentifying coronary calcification, including plain"nradiography, fluoroscopy, intravascular ultrasound,"nMRI, echocardiography, and conventional, helical and"nelectron-beam CT (EBCT. Coronary calcifications"ndetected on EBCT or helical CT can be quantifie,"nand a total calcification score (Cardiac Calcification"nScoring may be calculated. In an asymptomatic"npopulation and/or patients with concomitant risk"nfactors like diabetes mellitus, determination of the"npresence of coronary calcifications identifies the"npatients at risk for future myocardial infarction and"ncoronary artery disease. In patients without coronary"ncalcifications, future cardiovascular events could"nbe excluded. Therefore, detecting and recognizing"ncalcification related to the heart on chest radiography"nand other imaging modalities such as fluoroscopy, CT"nand echocardiography may have important clinical"nimplications.

  6. Anatomy of the Vestibulo-automatic Outflow to the Gut

    Science.gov (United States)

    Torigoe, Y.

    1985-01-01

    Motion sickness can be induced by vestibular effects on the sympathetic portion of the autonomic nervous system. However, the pathways linking the vestibular and autonomic pathways are unknown. As a first step in this analysis, the locations of preganglionic sympathetic neurons (PSN) and dorsal root afferent ganglionic neurons (DRG) which supply sympathetic innervation to major portions of the gastrointestinal tract in rabbits were identified. The objective of a second series of experiments is to determine which of the brainstem nuclei project to the autonomic regions of the spinal cord that control gastrointestinal motility. To achieve this goal, a trans-synaptic retrograde tracer (3H-tetanus toxoid) is applied to the greater splanchnic nerve. This method allows the labeling of neurons within the brainstem that project only to the preganglionic synpathetic neurons. One structure that has been strongly implicated in mediating vestibulo-autonomic control is the cerebellum (i.e., nodulus and uvula). The outflow of these lobules to the autonomic regions of the brainstem is mediated by the fastigial nucleus. To determine the precise projections of the fastigial nucleus to the brainstem nuclei involved in emesis, anterograde tracer (3H-leucine) was injected into the fastigial nucleus in a third series of experiments.

  7. In vivo mechanical study of helical cardiac pacing electrode interacting with canine myocardium

    Science.gov (United States)

    Zhang, Xiangming; Ma, Nianke; Fan, Hualin; Niu, Guodong; Yang, Wei

    2007-06-01

    Cardiac pacing is a medical device to help human to overcome arrhythmia and to recover the regular beats of heart. A helical configuration of electrode tip is a new type of cardiac pacing lead distal tip. The helical electrode attaches itself to the desired site of heart by screwing its helical tip into the myocardium. In vivo experiments on anesthetized dogs were carried out to measure the acute interactions between helical electrode and myocardium during screw-in and pull-out processes. These data would be helpful for electrode tip design and electrode/myocardium adherence safety evaluation. They also provide reliability data for clinical site choice of human heart to implant and to fix the pacing lead. A special design of the helical tip using strain gauges is instrumented for the measurement of the screw-in and pull-out forces. We obtained the data of screw-in torques and pull-out forces for five different types of helical electrodes at nine designed sites on ten canine hearts. The results indicate that the screw-in torques increased steplike while the torque time curves presente saw-tooth fashion. The maximum torque has a range of 0.3 1.9 N mm. Obvious differences are observed for different types of helical tips and for different test sites. Large pull-out forces are frequently obtained at epicardium of left ventricle and right ventricle lateral wall, and the forces obtained at right ventricle apex and outflow tract of right ventricle are normally small. The differences in pull-out forces are dictated by the geometrical configuration of helix and regional structures of heart muscle.

  8. In vivo mechanical study of helical cardiac pacing electrode interacting with canine myocardium

    Institute of Scientific and Technical Information of China (English)

    Xiangming Zhang; Nianke Ma; Hualin Fan; Guodong Niu; Wei Yang

    2007-01-01

    Cardiac pacing is a medical device to help human to overcome arrhythmia and to recover the regular beats of heart. A helical configuration of electrode tip is a new type of cardiac pacing lead distal tip. The helical electrode attaches itself to the desired site of heart by screwing its helical tip into the myocardium. In vivo experiments on anesthetized dogs were carried out to measure the acute interactions between helical electrode and myocardium during screw-in and pull-out processes. These data would be helpful for electrode tip design and electrode/myocardium adherence safety evaluation. They also provide reliability data for clinical site choice of human heart to implant and to fix the pacing lead.A special design of the helical tip using strain gauges is instrumented for the measurement of the screw-in and pull-out forces. We obtained the data of screw-in torques and pull-out forces for five different types of helical electrodes at nine designed sites on ten canine hearts. The results indicate that the screw-in torques increased steplike while the torque-time curves presente saw-tooth fashion. The maximum torque has a range of 0.3-1.9N mm. Obvious differences are observed for different types of helical tips and for different test sites.Large pull-out forces are frequently obtained at epicardium of left ventricle and right ventricle lateral wall, and the forces obtained at right ventricle apex and outflow tract of right ventricle are normally small. The differences in pull-out forces are dictated by the geometrical configuration of helix and regional structures of heart muscle.

  9. In situ cardiac perfusion reveals interspecific variation of intraventricular flow separation in reptiles.

    Science.gov (United States)

    Joyce, William; Axelsson, Michael; Altimiras, Jordi; Wang, Tobias

    2016-07-15

    The ventricles of non-crocodilian reptiles are incompletely divided and provide an opportunity for mixing of oxygen-poor blood and oxygen-rich blood (intracardiac shunting). However, both cardiac morphology and in vivo shunting patterns exhibit considerable interspecific variation within reptiles. In the present study, we develop an in situ double-perfused heart approach to characterise the propensity and capacity for shunting in five reptile species: the turtle Trachemys scripta, the rock python Python sebae, the yellow anaconda Eunectes notaeus, the varanid lizard Varanus exanthematicus and the bearded dragon Pogona vitticeps To simulate changes in vascular bed resistance, pulmonary and systemic afterloads were independently manipulated and changes in blood flow distribution amongst the central outflow tracts were monitored. As previously demonstrated in Burmese pythons, rock pythons and varanid lizards exhibited pronounced intraventricular flow separation. As pulmonary or systemic afterload was raised, flow in the respective circulation decreased. However, flow in the other circulation, where afterload was constant, remained stable. This correlates with the convergent evolution of intraventricular pressure separation and the large intraventricular muscular ridge, which compartmentalises the ventricle, in these species. Conversely, in the three other species, the pulmonary and systemic flows were strongly mutually dependent, such that the decrease in pulmonary flow in response to elevated pulmonary afterload resulted in redistribution of perfusate to the systemic circuit (and vice versa). Thus, in these species, the muscular ridge appeared labile and blood could readily transverse the intraventricular cava. We conclude that relatively minor structural differences between non-crocodilian reptiles result in the fundamental changes in cardiac function. Further, our study emphasises that functionally similar intracardiac flow separation evolved independently in

  10. Pediatric urinary tract infection

    International Nuclear Information System (INIS)

    Acute urinary tract infection (UTI) is an important cause of morbidity in children and may be complicated by congenital urinary tract abnormalities of a functional or anatomic nature which, predispose to recurrent UTI's that in turn may lead to renal failure and hypertension. Early radiologic and ultrasonographic investigations may reveal these anatomic anomalies in particular because the urinary tract, specifically in children, is not readily accessible to adequate clinical examinations Excretory urography (EU) has been considered as the 'gold standard' of upper urinary tract visualization, while the voiding cystourethrogram (VCUG) was thought to be the preferential method of imaging of the lower urinary tract. Recently, major technical advances have altered this commonly accepted diagnostic workup. Although ultrasonography, radio-nuclide scanning and urodynamics have become important contributors to the understanding of pathophysiology of UTI's their value and place in assessment of the sequence of imaging has not been comprehensively studied. This thesis deals about the optimization of the choice and the order of the different imaging techniques used in the evaluation of children, younger than six year with UTI. (author). 243 refs.; 23 figs.; 8 tabs

  11. Accretion, winds and outflows in young stars

    Science.gov (United States)

    Günther, H. M.

    2013-02-01

    Young stars and planetary systems form in molecular clouds. After the initial radial infall an accretion disk develops. For classical T Tauri stars (CTTS, F-K type precursors) the accretion disk does not reach down to the central star, but it is truncated near the co-rotation radius by the stellar magnetic field. The inner edge of the disk is ionized by the stellar radiation, so that the accretion stream is funneled along the magnetic field lines. On the stellar surface an accretion shock develops, which is observed over a wide wavelength range as X-ray emission, UV excess, optical veiling and optical and IR emission lines. Some of the accretion tracers, e.g. Hα, can be calibrated to measure the accretion rate. This accretion process is variable on time scales of hours to years due to changing accretion rates, stellar rotation and reconfiguration of the magnetic field. Furthermore, many (if not all) accreting systems also drive strong outflows which are ultimately powered by accretion. However, the exact driving mechanism is still unclear. Several components could contribute to the outflows: slow, wide-angle disk winds, X-winds launched close to the inner disk rim, and thermally driven stellar winds. In any case, the outflows contain material of very different temperatures and speeds. The disk wind is cool and can have a molecular component with just a few tens of km s-1, while the central component of the outflow can reach a few 100 km s-1. In some cases the inner part of the outflow is collimated to a small-angle jet. These jets have an onion-like structure, where the inner components are consecutively hotter and faster. The jets can contain working surfaces, which show up as Herbig-Haro knots. Accretion and outflows in the CTTS phase do not only determine stellar parameters like the rotation rate on the main-sequence, they also can have a profound impact on the environment of young stars. This review concentrates on CTTS in near-by star forming regions where

  12. Cardiac conduction system

    Science.gov (United States)

    The cardiac conduction system is a group of specialized cardiac muscle cells in the walls of the heart that send signals ... to contract. The main components of the cardiac conduction system are the SA node, AV node, bundle ...

  13. Protostellar outflows with Smoothed Particle Magnetohydrodynamics (SPMHD)

    CERN Document Server

    Bürzle, Florian; Stasyszyn, Federico; Dolag, Klaus; Klessen, Ralf S

    2011-01-01

    The protostellar collapse of a molecular cloud core is usually accompanied by outflow phenomena. The latter are thought to be driven by magnetorotational processes from the central parts of the protostellar disc. While several 3D AMR/nested grid studies of outflow phenomena in collapsing magnetically supercritical dense cores have been reported in the literature, so far no such simulation has been performed using the Smoothed Particle Hydrodynamics (SPH) method. This is mainly due to intrinsic numerical difficulties in handling magnetohydrodynamics within SPH, which only recently were partly resolved. In this work, we use an approach where we evolve the magnetic field via the induction equation, augmented with stability correction and divergence cleaning schemes. We consider the collapse of a rotating core of one solar mass, threaded by a weak magnetic field initially parallel to the rotation axis so that the core is magnetically supercritical. We show, that Smoothed Particle Magnetohydrodynamics (SPMHD) is a...

  14. Hepatic venous outflow obstruction: Three similar syndromes

    Institute of Scientific and Technical Information of China (English)

    Ulas Darda Bayraktar; Soley Seren; Yusuf Bayraktar

    2007-01-01

    Our goal is to provide a detailed review of venoocclusive disease (VOD), Budd-Chiari syndrome (BCS),and congestive hepatopathy (CH), all of which results in hepatic venous outflow obstruction. This is the first article in which all three syndromes have been reviewed,enabling the reader to compare the characteristics of these disorders. The histological findings in VOD, BCS,and CH are almost identical: sinusoidal congestion and cell necrosis mostly in perivenular areas of hepatic acini which eventually leads to bridging fibrosis between adjacent central veins. Tender hepatomegaly with jaundice and ascites is common to all three conditions.However, the clinical presentation depends mostly on the extent and rapidity of the outflow obstruction.Although the etiology and treatment are completely different in VOD, BCS, and CH; the similarities in clinical manifestations and liver histology may suggest a common mechanism of hepatic injury and adaptation in response to increased sinusoidal pressure.

  15. Extracellular Matrix Turnover and Outflow Resistance

    OpenAIRE

    Kate E Keller; Mini, Aga; Bradley, John M.; Kelley, Mary J.; Acott, Ted S.

    2008-01-01

    Normal homeostatic adjustment of elevated intraocular pressure (IOP) involves remodeling the extracellular matrix (ECM) of the trabecular meshwork (TM). This entails sensing elevated IOP, releasing numerous activated proteinases to degrade existing ECM and concurrent biosynthesis of replacement ECM components. To increase or decrease IOP, the quantity, physical properties and/or organization of new components should be somewhat different from those replaced in order to modify outflow resistan...

  16. DLA kinematics and outflows from starburst galaxies

    CERN Document Server

    Razoumov, Alexei O

    2008-01-01

    We present results from a numerical study of the multiphase interstellar medium in sub-Lyman-break galaxy protogalactic clumps. Such clumps are abundant at z=3 and are thought to be a major contributor to damped Ly-alpha absorption. We model the formation of winds from these clumps and show that during star formation episodes they feature outflows with neutral gas velocity widths up to several hundred km/s. Such outflows are consistent with the observed high-velocity dispersion in DLAs. In our models thermal energy feedback from winds and supernovae results in efficient outflows only when cold (~ 300 K), dense (> 100 msun/pc^3) clouds are resolved at grid resolution of 12 pc. At lower 24 pc resolution the first signs of the multiphase medium are spotted; however, at this low resolution thermal injection of feedback energy cannot yet create hot expanding bubbles around star-forming regions -- instead feedback tends to erase high-density peaks and suppress star formation. At 12 pc resolution feedback compresses...

  17. Hot Electromagnetic Outflows I: Acceleration and Spectra

    CERN Document Server

    Russo, Matthew

    2013-01-01

    The theory of cold, relativistic, magnetohydrodynamic outflows is generalized by the inclusion of an intense radiation source. In some contexts, such the breakout of a gamma-ray burst jet from a star, the outflow is heated to a high temperature at a large optical depth. Eventually it becomes transparent and is pushed to a higher Lorentz factor by a combination of the Lorentz force and radiation pressure. We obtain its profile, both inside and outside the fast magnetosonic critical point, when the poloidal magnetic field is radial and monopolar. Most of the energy flux is carried by the radiation field and the toroidal magnetic field that is wound up close to the rapidly rotating engine. Although the entrained matter carries little energy, it couples the radiation field to the magnetic field. Then the fast critical point is pushed inward from infinity and, above a critical radiation intensity, the outflow is accelerated mainly by radiation pressure. We identify a distinct observational signature of this hybrid...

  18. Magnotospheric imaging of high latitude ion outflows

    Directory of Open Access Journals (Sweden)

    D. E. Garrido

    Full Text Available High latitude ion outflows mostly consist of upward streaming O+ and He+ emanating from the ionosphere. At heights above 1000 km, these flows consist of cold and hot components which resonantly scatter solar extreme ultraviolet (EUV light, however, the ion populations respond differently to Doppler shifting resulting from the large relative velocities between the ions and the Sun. The possibility of optical detection of the Doppler effect on the scattering rate will be discussed for the O+ (83.4 nm ions. We have contrasted the EUV solar resonance images of these outflows by simulations of the 30.4 nm He+ and 83.4 nm O+ emissions for both quiet and disturbed geomagnetic conditions. Input data for the 1000 km level has been obtained from the EICS instrument aboard the Dynamics Explorer satellite. Our results show emission rates of 50 and 56 milli-Rayleighs at 30.4 nm for quiet and disturbed conditions and 65 and 75 milli-Rayleighs at 83.4 nm for quiet and disturbed conditions, respectively, obtained for a polar orbiting satellite and viewing radially outward. We also find that an imager at an equatorial distance of 9 RE or more is in a favourable position for detecting ion outflows, particularly when the plasmapause is depressed in latitude. However, an occultation disk is necessary to obscure the bright plasmaspheric emissions.

  19. Induced apnea enhances image quality and visualization of cardiopulmonary anatomic during contrastenhanced cardiac computerized tomographic angiography in children

    Directory of Open Access Journals (Sweden)

    Murali Chakravarthy

    2015-01-01

    Full Text Available Objective: The purpose of our study was to determine the effect of induced apnea on quality of cardiopulmonary structures during computerized tomographic (CT angiography images in children with congenital heart diseases. Methods: Pediatric patients with congenital heart defects undergoing cardiac CT angiography at our facility in the past 3 years participated in this study. The earlier patients underwent cardiac CT angiography without induced apnea and while, later, apnea was induced in patients, which was followed by electrocardiogram gated cardiac CT angiography. General anesthesia was induced using sleep dose of intravenous propofol. After the initial check CT, on request by the radiologist, apnea was induced by the anesthesiologist by administering 1 mg/kg of intravenous suxamethonium. Soon after apnea ensued, the contrast was injected, and CT angiogram carried out. CT images in the "apnea group" were compared with those in "nonapnea group." After the completion of the procedure, the patients were mask ventilated with 100% oxygen till the spontaneous ventilation was restored. Results: We studied 46 patients, of whom 36 with apnea and yet another 10 without. The quality of the image, visualization of structures such as cardiac wall, outflow tracts, lung field, aortopulmonary shunts, and coronary arteries were analyzed and subjected to statistical analysis (Mann-Whitney U, Fischer′s exact test and Pearson′s Chi-square test. In the induced apnea group, overall image quality was considered excellent in 89% (n = 33 of the studies, while in the "no apnea group," only 30% of studies were excellent. Absent or minimal motion artifacts were seen in a majority of the studies in apnea group (94%. In the nonapnea group, the respiratory and body motion artifacts were severe in 50%, moderate in 30%, and minimal in 20%, but they were significantly lesser in the apnea group. All the studied parameters were statistically significant in the apnea group in

  20. A Robust Measurement of the Mass Outflow Rate of the Galactic Outflow from NGC 6090

    CERN Document Server

    Chisholm, John; Leitherer, Claus; Chen, Yanmei

    2016-01-01

    To evaluate the impact of stellar feedback, it is critical to estimate the mass outflow rates of galaxies. Past estimates have been plagued by uncertain assumptions about the outflow geometry, metallicity, and ionization fraction. Here we use Hubble Space Telescope ultraviolet spectroscopic observations of the nearby starburst NGC 6090 to demonstrate that many of these quantities can be constrained by the data. We use the Si~{\\sc IV} absorption lines to calculate the scaling of velocity (v), covering fraction (C$_f$), and density with distance from the starburst (r), assuming the Sobolev optical depth and a velocity law of the form: $v \\propto(1 -R_i/r )^\\beta$ (were R$_i$ is the inner outflow radius). We find that the velocity ($\\beta$=0.43) is consistent with an outflow driven by an r$^{-2}$ force, while the scaling of the covering fraction ($C_f \\propto r^{-0.82}$) suggests that cool clouds in the outflow are in pressure equilibrium with an adiabatically expanding medium. We use the column densities of fou...

  1. Urinary Tract Infections (UTIs)

    Medline Plus

    Full Text Available ... might have the feeling that you need to go to the bathroom all the time. And when you do, phew! Your pee smells bad. These changes occur because bacteria have caused an infection somewhere in your urinary tract. Let's find out more. What Exactly Is a Urinary ...

  2. Urinary Tract Infections.

    Science.gov (United States)

    Plummer, Nancy; Michael, Nancy, Ed.

    This module on urinary tract infections is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are…

  3. Midterm results of bovine jugular vein conduit for right ventricular outflow tract reconstruction

    International Nuclear Information System (INIS)

    Objective: To evaluate the midterm results of Contegra conduit. Methods: The retrospective study comprised patient record at Aga Khan University Hospital, Karachi, of conduits implanted between May 2007 and June 2012. Data collection was made from the clinical notes and from serial echocardiograms by a single cardiologist. The last followup echocardiography was done at the time of data collection in June 2012. SPSS 19 was used for statistical analysis. Results: A total of 18 conduits had been implanted (16-22mm) during the study period. Median age at the time of surgery was 9 years (range: 2.5-16 years). Early mortality was seen in 3 (16.66%) patients, but none was Contegra related. Of the remaining 15 patients, 2 (13.33%) with a diagnosis of Pulmonary Atresia-Ventricular Septal Defect with hypoplastic peripheral Pulmonary Arteries (PA), developed severe distal pressure gradient (50mmHg) across Contegra over a median period of 18 months (range: 12-24 months), with resultant severe regurgitation and needed percutaneous intervention. There was no thrombosis, calcification, anuerysmal dilation or late deaths. Conclusion: At midterm followup, Contegra conduit was associated with low re-intervention rates with satisfactory haemodynamic results. However, long-term durability must be determined for this conduit, especially in patients with Pulmonary Atresia-Ventricular Septal Defect with hypoplastic peripheral Pulmonary Arteries. (author)

  4. [Severe left ventricular outflow tract obstruction as a complication of mitral valve repair: case report].

    Science.gov (United States)

    Rodrigues, Bruno; Santos, Luís Ferreira; Correia, Emanuel; Faria, Rita; Moreira, Davide; Gama, Pedro; Cabral, Costa; Pipa, João; Santos, Oliveira

    2011-11-01

    Systolic anterior motion (SAM) is a postoperative complication of mitral valve repair, with an incidence of 5 to 10%. Early recognition of the signs and symptoms of SAM is essential for the management of these patients. This article focuses on the pathophysiology and dynamics of SAM and the treatment strategies described in the literature. The authors present a case study and echocardiographic images illustrating the clinical relevance of the mechanism involved, in order to clarify whether surgical reintervention is necessary. PMID:22032955

  5. Regression of outflow tract obstruction subsequent to treatment with verapamil in hypertrophic obstructive cardiomyopathy

    DEFF Research Database (Denmark)

    Frandsen, F; Mickley, H

    1990-01-01

    A 29-year-old man suffering from hypertrophic obstructive cardiomyopathy was treated with verapamil 240 mg daily for 4.5 years. During this period the symptoms were reduced, and an intraventricular gradient diminished from 80 to 20 mm Hg, possibly due to a decrease in left ventricular ejection...

  6. Exercise-Induced Right Ventricular Outflow Tract Tachycardia in a Patient with Isolated Left Ventricular Noncompaction

    OpenAIRE

    Mehmet Eren; Erkan İlhan; Ahmet Taha Alper; Tolga Sinan Güvenç

    2011-01-01

    Isolated left ventricular noncompaction is a hereditary cardiomyopathy in which a variety of supraventricular and ventricular arrhythmias could be observed. We report a patient with exercise-induced ventricular tachycardia with left bundle branch block morphology that had characteristics of an idiopathic ventricular tachycardia who was subsequently diagnosed as left ventricular noncompaction. Successful remission of arrhythmia was ensured after the introduction of oral beta-blocker therapy.

  7. Urinary Tract Infections in Children

    Science.gov (United States)

    ... Disease Organizations​​ . (PDF, 345 KB) Alternate Language URL Urinary Tract Infections in Children Page Content On this page: What ... Points to Remember Clinical Trials What is a urinary tract infection (UTI)? A UTI is an infection in the ...

  8. Cardiac MRI in Athletes

    NARCIS (Netherlands)

    Luijkx, T.

    2012-01-01

    Cardiac magnetic resonance imaging (CMR) is often used in athletes to image cardiac anatomy and function and is increasingly requested in the context of screening for pathology that can cause sudden cardiac death (SCD). In this thesis, patterns of cardiac adaptation to sports are investigated with C

  9. Shock Waves in Outflows from Young Stars

    Science.gov (United States)

    Hartigan, Patrick

    This review focuses on physics of the cooling zones behind radiative shocks and the emission line diagnostics that can be used to infer physical conditions and mass loss rates in jets from young stars. Spatial separations of the cooling zones from the shock fronts, now resolvable with HST, and recent evidence for C-shocks have greatly increased our understanding of how shocks in outflows interact with the surrounding medium and with other material within the flow. By combining multiple epoch HST images, one can create `movies' of flows like those produced from numerical codes, and learn what kinds of instabilities develop within these systems.

  10. Iodine-131 monitoring in sewage plant outflow

    International Nuclear Information System (INIS)

    Three different hospital sites (Oxford, Sutton and Guildford) have performed sampling of their local sewage plant outflow to determine levels of radioactivity resulting from iodine-131 patients undergoing radionuclide therapies. It was found that a maximum of 20% of activity discharged from the hospitals was present in the sewage plant final effluent channel. This is significantly below the level predicted by mathematical models in current use. The results further show that abatement systems to reduce public exposure are unlikely to be warranted at hospital sites. (paper)

  11. GGD 37: An Extreme Protostellar Outflow

    CERN Document Server

    Green, J D; Bergin, E; Maret, S; Melnick, G; Sonnentrucker, P; Tolls, V; Sargent, B A; Forrest, W J; Kim, K H; Raines, S N

    2010-01-01

    We present the first Spitzer-IRS spectral maps of the Herbig-Haro flow GGD 37 detected in lines of [Ne III], [O IV], [Ar III], and [Ne V]. The detection of extended [O IV] (55 eV) and some extended emission in [Ne V] (97 eV) indicates a shock temperature in excess of 100,000 K, in agreement with X-ray observations, and a shock speed in excess of 200 km s-1. The presence of an extended pho- toionization or collisional ionization region indicates that GGD 37 is a highly unusual protostellar outflow.

  12. Radiology illustrated. Gastrointestinal tract

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Byung Ihn (ed.) [Seoul National University Hospital (Korea, Republic of). Dept. of Radiology

    2015-02-01

    Radiology Illustrated: Gastrointestinal Tract is the second of two volumes designed to provide clear and practical guidance on the diagnostic imaging of abdominal diseases. The book presents approximately 300 cases with 1500 carefully selected and categorized illustrations of gastrointestinal tract diseases, along with key text messages and tables that will help the reader easily to recall the relevant images as an aid to differential diagnosis., Essential points are summarized at the end of each text message to facilitate rapid review and learning. Additionally, brief descriptions of each clinical problem are provided, followed by case studies of both common and uncommon pathologies that illustrate the roles of the different imaging modalities, including ultrasound, radiography, computed tomography, and magnetic resonance imaging.

  13. Abnormal cardiac autonomic regulation in mice lacking ASIC3.

    Science.gov (United States)

    Cheng, Ching-Feng; Kuo, Terry B J; Chen, Wei-Nan; Lin, Chao-Chieh; Chen, Chih-Cheng

    2014-01-01

    Integration of sympathetic and parasympathetic outflow is essential in maintaining normal cardiac autonomic function. Recent studies demonstrate that acid-sensing ion channel 3 (ASIC3) is a sensitive acid sensor for cardiac ischemia and prolonged mild acidification can open ASIC3 and evoke a sustained inward current that fires action potentials in cardiac sensory neurons. However, the physiological role of ASIC3 in cardiac autonomic regulation is not known. In this study, we elucidate the role of ASIC3 in cardiac autonomic function using Asic3(-/-) mice. Asic3(-/-) mice showed normal baseline heart rate and lower blood pressure as compared with their wild-type littermates. Heart rate variability analyses revealed imbalanced autonomic regulation, with decreased sympathetic function. Furthermore, Asic3(-/-) mice demonstrated a blunted response to isoproterenol-induced cardiac tachycardia and prolonged duration to recover to baseline heart rate. Moreover, quantitative RT-PCR analysis of gene expression in sensory ganglia and heart revealed that no gene compensation for muscarinic acetylcholines receptors and beta-adrenalin receptors were found in Asic3(-/-) mice. In summary, we unraveled an important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli, which reveals new implications for therapy in autonomic nervous system-related cardiovascular diseases. PMID:24804235

  14. Abnormal Cardiac Autonomic Regulation in Mice Lacking ASIC3

    Directory of Open Access Journals (Sweden)

    Ching-Feng Cheng

    2014-01-01

    Full Text Available Integration of sympathetic and parasympathetic outflow is essential in maintaining normal cardiac autonomic function. Recent studies demonstrate that acid-sensing ion channel 3 (ASIC3 is a sensitive acid sensor for cardiac ischemia and prolonged mild acidification can open ASIC3 and evoke a sustained inward current that fires action potentials in cardiac sensory neurons. However, the physiological role of ASIC3 in cardiac autonomic regulation is not known. In this study, we elucidate the role of ASIC3 in cardiac autonomic function using Asic3−/− mice. Asic3−/− mice showed normal baseline heart rate and lower blood pressure as compared with their wild-type littermates. Heart rate variability analyses revealed imbalanced autonomic regulation, with decreased sympathetic function. Furthermore, Asic3−/− mice demonstrated a blunted response to isoproterenol-induced cardiac tachycardia and prolonged duration to recover to baseline heart rate. Moreover, quantitative RT-PCR analysis of gene expression in sensory ganglia and heart revealed that no gene compensation for muscarinic acetylcholines receptors and beta-adrenalin receptors were found in Asic3−/− mice. In summary, we unraveled an important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli, which reveals new implications for therapy in autonomic nervous system-related cardiovascular diseases.

  15. Discovery of Relativistic Outflow in the Seyfert Galaxy Ark 564

    OpenAIRE

    Gupta, A; Mathur, S; Krongold, Y.; F. Nicastro

    2013-01-01

    We present \\chandra high energy transmission grating spectra of the narrow-line Seyfert-1 galaxy Ark 564. The spectrum shows numerous absorption lines which are well modeled with low velocity outflow components usually observed in Seyfert galaxies \\citep{Gupta2013}. There are, however, some residual absorption lines which are not accounted for by low-velocity outflows. Here we present identifications of the strongest lines as $K\\alpha$ transitions of \\oviin (two lines) and \\ovin at outflow ve...

  16. Cumulative neutrino background from quasar-driven outflows

    CERN Document Server

    Wang, Xiawei

    2016-01-01

    Quasar-driven outflows naturally account for the missing component of the extragalactic $\\gamma$-ray background through neutral pion production in interactions between protons accelerated by the forward outflow shock and interstellar protons. We study the simultaneous neutrino emission by the same protons. We adopt outflow parameters that best fit the extragalactic $\\gamma$-ray background data and derive a cumulative neutrino background of $\\sim10^{-7}\\,\\rm GeV\\,cm^{-2}\\,s^{-1}\\,sr^{-1}$ at neutrino energies $E_{\

  17. DISCOVERY OF RELATIVISTIC OUTFLOW IN THE SEYFERT GALAXY Ark 564

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, A.; Mathur, S. [Astronomy Department, Ohio State University, Columbus, OH 43210 (United States); Krongold, Y. [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Mexico City (Mexico); Nicastro, F., E-mail: agupta@astronomy.ohio-state.edu [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States)

    2013-07-20

    We present Chandra High Energy Transmission Grating Spectra of the narrow-line Seyfert-1 galaxy Ark 564. The spectrum shows numerous absorption lines which are well modeled with low-velocity outflow components usually observed in Seyfert galaxies. There are, however, some residual absorption lines which are not accounted for by low-velocity outflows. Here, we present identifications of the strongest lines as K{alpha} transitions of O VII (two lines) and O VI at outflow velocities of {approx}0.1c. These lines are detected at 6.9{sigma}, 6.2{sigma}, and 4.7{sigma}, respectively, and cannot be due to chance statistical fluctuations. Photoionization models with ultra-high velocity components improve the spectral fit significantly, providing further support for the presence of relativistic outflow in this source. Without knowing the location of the absorber, its mass and energy outflow rates cannot be well constrained; we find E-dot (outflow)/L{sub bol} lower limit of {>=}0.006% assuming a bi-conical wind geometry. This is the first time that absorption lines with ultra-high velocities are unambiguously detected in the soft X-ray band. The presence of outflows with relativistic velocities in active galactic nuclei (AGNs) with Seyfert-type luminosities is hard to understand and provides valuable constraints to models of AGN outflows. Radiation pressure is unlikely to be the driving mechanism for such outflows and magnetohydrodynamic may be involved.

  18. Discovery of Relativistic Outflow in the Seyfert Galaxy Ark 564

    Science.gov (United States)

    Gupta, A.; Mathur, S.; Krongold, Y.; Nicastro, F.

    2013-07-01

    We present Chandra High Energy Transmission Grating Spectra of the narrow-line Seyfert-1 galaxy Ark 564. The spectrum shows numerous absorption lines which are well modeled with low-velocity outflow components usually observed in Seyfert galaxies. There are, however, some residual absorption lines which are not accounted for by low-velocity outflows. Here, we present identifications of the strongest lines as Kα transitions of O VII (two lines) and O VI at outflow velocities of ~0.1c. These lines are detected at 6.9σ, 6.2σ, and 4.7σ, respectively, and cannot be due to chance statistical fluctuations. Photoionization models with ultra-high velocity components improve the spectral fit significantly, providing further support for the presence of relativistic outflow in this source. Without knowing the location of the absorber, its mass and energy outflow rates cannot be well constrained; we find \\dot{E}(outflow)/L_{bol} lower limit of >=0.006% assuming a bi-conical wind geometry. This is the first time that absorption lines with ultra-high velocities are unambiguously detected in the soft X-ray band. The presence of outflows with relativistic velocities in active galactic nuclei (AGNs) with Seyfert-type luminosities is hard to understand and provides valuable constraints to models of AGN outflows. Radiation pressure is unlikely to be the driving mechanism for such outflows and magnetohydrodynamic may be involved.

  19. Suppression of galactic outflows by cosmological infall and circumgalactic medium

    Science.gov (United States)

    Singh, Priyanka; Rana, Sandeep; Bagla, Jasjeet S.; Nath, Biman B.

    2016-06-01

    We investigate the relative importance of two galactic outflow suppression mechanisms: (a) cosmological infall of the intergalactic gas on to the galaxy, and (b) the existence of a hot circumgalactic medium (CGM). Considering only radial motion, the infall reduces the speed of outflowing gas and even halts the outflow, depending on the mass and redshift of the galaxy. For star-forming galaxies, there exists an upper mass limit beyond which outflows are suppressed by the gravitational field of the galaxy. We find that infall can reduce this upper mass limit approximately by a factor of 2 (independent of the redshift). Massive galaxies (≳1012 M⊙) host large reservoir of hot, diffuse CGM around the central part of the galaxy. The CGM acts as a barrier between the infalling and outflowing gas and provides an additional source of outflow suppression. We find that at low redshifts (z ≲ 3.5), the CGM is more effective than the infall in suppressing the outflows. Together, these two processes give a mass range in which galaxies are unable to have effective outflows. We also discuss the impact of outflow suppression on the enrichment history of the galaxy and its environment.

  20. Angiotensin II--nitric oxide interactions in the control of sympathetic outflow in heart failure.

    Science.gov (United States)

    Zucker, I H; Liu, J L

    2000-03-01

    Activation of the sympathetic nervous system is a compensatory mechanism which initially provides support for the circulation in the face of a falling cardiac output. It has been recognized for some time that chronic elevation of sympathetic outflow with the consequent increase in plasma norepinephrine, is counterproductive to improving cardiac function. Indeed, therapeutic targeting to block excessive sympathetic activation in heart failure is becoming a more accepted modality. The mechanism(s) by which sympathetic excitation occurs in the heart failure state are not completely understood. Components of abnormal cardiovascular reflex regulation most likely contribute to this sympatho-excitation. However, central mechanisms which relate to the elaboration of angiotensin II (Ang II) and nitric oxide (NO) may also play an important role. Ang II has been shown to be a sympatho-excitatory peptide in the central nervous system while NO is sympatho-inhibitory. Recent studies have demonstrated that blockade of Ang II receptors of the AT(1) subtype augments arterial baroreflex control of sympathetic nerve activity in the heart failure state, thereby predisposing to a reduction in sympathetic tone. Ang II and NO interact to regulate sympathetic outflow. Blockade of NO production in normal conscious rabbits was only capable of increasing sympathetic outflow when accompanied by a background infusion of Ang II. Conversely, providing a source of NO to rabbits with heart failure reduced sympathetic nerve activity when accompanied by blockade of AT(1) receptors. Chronic heart failure is also associated with a decrease in NO synthesis in the brain as indicated by a reduction in the mRNA for the neuronal isoform (nNOS). Chronic blockade of Ang II receptors can up regulate nNOS expression. In addition, exercise training of rabbits with developing heart failure has been shown to reduce sympathetic tone, decrease plasma Ang II, improve arterial baroreflex function and increase n

  1. Quasar feedback revealed by giant molecular outflows

    CERN Document Server

    Feruglio, Chiara; Piconcelli, Enrico; Menci, Nicola; Aussel, Herve'; Lamastra, Alessandra; Fiore, Fabrizio

    2010-01-01

    In the standard scenario for galaxy evolution the transformation of young star-forming galaxies into red bulge-dominated spheroids, where star formation has been quenched, is often explained by invoking a strong negative feedback generated by accretion onto a central super-massive black hole. The depletion of gas resulting from quasar-driven outflows should eventually stop star-formation across the host galaxy and lead to the black hole "suicide" for starvation. Direct observational evidence for a major quasar feedback onto the host galaxy is still missing, since outflows previously observed in quasars are associated with the ionized component of the gas, which only accounts for a minor fraction of the total gas content, and typically occur in the central regions. We used the IRAM PdBI to observe the CO(1-0) transition in Mrk 231, the closest quasar known. We detect broad wings of the CO line, with velocities up to 750 km/s and spatially resolved on the kpc scale. Such broad CO wings trace a giant molecular o...

  2. Magnetospheric and Thermospheric Influence on Ionospheric Outflow

    Science.gov (United States)

    Garcia-Sage, K.; Moore, T. E.; Mitchell, E. J.; Olson, D. K.

    2013-12-01

    The Fast Auroral SnapshoT (FAST) small explorer has been used extensively to study ionospheric outflow. Past research has used particle and field data to examine the contemporaneous transfer of electromagnetic energy and particle flow downward from the magnetosphere and upward from the ionosphere. Single event studies published by Strangeway et al. [2005] and Brambles et al. [2011, Supporting Online Material] showed that downward electromagnetic energy and particle flow into the ionosphere are correlated with the upward flow of ions out of the ionosphere. It is expected, however, that this correlation will be affected by circumstances that are unique to each specific event, including but not limited to the outflow location (cusp or nightside), preconditioning due to prior geomagnetic activity, and thermospheric neutral densities. Although knowledge of the thermospheric neutral density is usually unavailable, data from the CHAllenging Minisatellite Payload (CHAMP) is able to provide insight into thermospheric populations at altitudes of about 400 km for a few select events. We expand on the previously-mentioned studies by looking at FAST particle and field data for additional events, and we further examine the influence of thermospheric neutral populations, based on CHAMP data.

  3. Accretion, winds and outflows in young stars

    CERN Document Server

    Günther, Hans Moritz

    2012-01-01

    Young stars and planetary systems form in molecular clouds. For classical T Tauri stars (CTTS, F-K type precursors) the accretion disk does not reach down to the central star, but it is truncated near the co-rotation radius. The inner edge of the disk is ionized by the stellar radiation, so that the accretion stream is funneled along the magnetic field lines. On the stellar surface an accretion shock develops, which is observed over a wide wavelength range as X-ray emission, UV excess, optical veiling and optical and IR emission lines. Some of the accretion tracers, e.g. H\\alpha, can be calibrated to measure the accretion rate. This accretion process is variable on time scales of hours to years due to changing accretion rates, stellar rotation and reconfiguration of the magnetic field. Furthermore, many accreting systems also drive strong outflows which are ultimately powered by accretion. Several components could contribute to the outflows: slow, wide-angle disk winds, X-winds launched close to the inner dis...

  4. Power spectra of outflow-driven turbulence

    CERN Document Server

    Moraghan, Anthony; Yoon, Suk-Jin

    2015-01-01

    We investigate the power spectra of outflow-driven turbulence through high-resolution three-dimensional isothermal numerical simulations where the turbulence is driven locally in real-space by a simple spherical outflow model. The resulting turbulent flow saturates at an average Mach number of ~2.5 and is analysed through density and velocity power spectra, including an investigation of the evolution of the solenoidal and compressional components. We obtain a shallow density power spectrum with a slope of ~-1.2 attributed to the presence of a network of localised dense filamentary structures formed by strong shock interactions. The total velocity power spectrum slope is found to be ~-2.0, representative of Burgers shock dominated turbulence model. The density weighted velocity power spectrum slope is measured as ~-1.6, slightly less than the expected Kolmogorov scaling value (slope of -5/3) found in previous works. The discrepancy may be caused by the nature of our real space driving model and we suggest ther...

  5. Disks and Outflows Around Young Stars

    Science.gov (United States)

    Beckwith, Steven; Staude, Jakob; Quetz, Axel; Natta, Antonella

    The subject of the book, the ubiquitous circumstellar disks around very young stars and the corresponding jets of outflowing matter, has recently become one of the hottest areas in astrophysics. The disks are thought to be precursors to planetary systems, and the outflows are thought to be a necessary phase in the formation of a young star, helping the star to get rid of angular momentum and energy as it makes its way onto the main sequence. The possible connections to planetary systems and stellar astrophysics makes these topics especially broad, appealing to generalists and specialists alike. The CD not only contains papers that could not be printed in the book but allows the authors to include a fair amount of data, often displayed as color images. The CD-ROM contains all the contributions printed in the corresponding book (Lecture Notes in Physics Vol. 465) and, in addition, those presented exclusively in digital form. Each contribution consists of a file in portable document format (PDF). The electronic version allows full-text searching within each file using Adobe's Acrobat Reader providing instructions for installation on Unix (Sun), PC and Macintosh computers, respectively. All contributions can be printed out; the color diagrams and color frames, which are printed in black and white in the book, can be viewed in color on screen.

  6. Multidimensional chemical modelling, II. Irradiated outflow walls

    CERN Document Server

    Bruderer, Simon; Doty, Steven D; van Dishoeck, Ewine F; Bourke, Tyler L

    2009-01-01

    Observations of the high-mass star forming region AFGL 2591 reveal a large abundance of CO+, a molecule known to be enhanced by far UV (FUV) and X-ray irradiation. In chemical models assuming a spherically symmetric envelope, the volume of gas irradiated by protostellar FUV radiation is very small due to the high extinction by dust. The abundance of CO+ is thus underpredicted by orders of magnitude. In a more realistic model, FUV photons can escape through an outflow region and irradiate gas at the border to the envelope. Thus, we introduce the first 2D axi-symmetric chemical model of the envelope of a high-mass star forming region to explain the CO+ observations as a prototypical FUV tracer. The model assumes an axi-symmetric power-law density structure with a cavity due to the outflow. The local FUV flux is calculated by a Monte Carlo radiative transfer code taking scattering on dust into account. A grid of precalculated chemical abundances, introduced in the first part of this series of papers, is used to ...

  7. Ionized Outflows from Compact Steep Spectrum Sources

    CERN Document Server

    Shih, Hsin-Yi; Kewley, Lisa

    2013-01-01

    Massive outflows are known to exist, in the form of extended emission-line regions (EELRs), around about one-third of powerful FR II radio sources. We investigate the origin of these EELRs by studying the emission-line regions around compact-steep-spectrum (CSS) radio galaxies that are younger (10$^3$ to 10$^5$ years old) versions of the FR II radio galaxies. We have searched for and analyzed the emission-line regions around 11 CSS sources by taking integral field spectra using GMOS on Gemini North. We fit the [\\ion{O}{3}] $\\lambda 5007$ line and present the velocity maps for each detected emission-line region. We find, in most cases, that the emission-line regions have multi-component velocity structures with different velocity dispersions and/or flux distributions for each component. The velocity gradients of the emission-line gas are mostly well aligned with the radio axis, suggesting a direct causal link between the outflowing gas and the radio jets. The complex velocity structure may be a result of diffe...

  8. Accretion Disk Outflows from Compact Object Mergers

    Science.gov (United States)

    Metzger, Brian

    Nuclear reactions play a key role in the accretion disks and outflows associated with the merger of binary compact objects and the central engines of gamma-ray bursts and supernovae. The proposed research program will investigate the impact of nucleosynthesis on these events and their observable signatures by means of analytic calculations and numerical simulations. One focus of this research is rapid accretion following the tidal disruption of a white dwarf (WD) by a neutron star (NS) or black hole (BH) binary companion. Tidal disruption shreds the WD into a massive torus composed of C, O, and/or He, which undergoes nuclear reactions and burns to increasingly heavier elements as it flows to smaller radii towards the central compact object. The nuclear energy so released is comparable to that released gravitationally, suggesting that burning could drastically alter the structure and stability of the accretion flow. Axisymmetric hydrodynamic simulations of the evolution of the torus including nuclear burning will be performed to explore issues such as the mass budget of the flow (accretion vs. outflows) and its thermal stability (steady burning and accretion vs. runaway explosion). The mass, velocity, and composition of outflows from the disk will be used in separate radiative transfer calculations to predict the lightcurves and spectra of the 56Ni-decay powered optical transients from WD-NS/WD-BH mergers. The possible connection of such events to recently discovered classes of sub-luminous Type I supernovae will be assessed. The coalescence of NS-NS/NS-BH binaries also results in the formation of a massive torus surrounding a central compact object. Three-dimensional magnetohydrodynamic simulations of the long-term evolution of such accretion disks will be performed, which for the first time follow the effects of weak interactions and the nuclear energy released by Helium recombination. The nucleosynthetic yield of disk outflows will be calculated using a detailed

  9. Cardiac perception and cardiac control. A review.

    Science.gov (United States)

    Carroll, D

    1977-12-01

    The evidence regarding specific cardiac perception and discrimination, and its relationship to voluntary cardiac control, is critically reviewed. Studies are considered in three sections, depending on the method used to assess cardiac perception: questionnaire assessment, discrimination procedures, and heartbeat tracking. The heartbeat tracking procedure would appear to suffer least from interpretative difficulties. Recommendations are made regarding the style of analysis used to assess heartbeat perception in such tracking tasks. PMID:348240

  10. Measurement of Outflow Facility Using iPerfusion.

    Directory of Open Access Journals (Sweden)

    Joseph M Sherwood

    Full Text Available Elevated intraocular pressure (IOP is the predominant risk factor for glaucoma, and reducing IOP is the only successful strategy to prevent further glaucomatous vision loss. IOP is determined by the balance between the rates of aqueous humour secretion and outflow, and a pathological reduction in the hydraulic conductance of outflow, known as outflow facility, is responsible for IOP elevation in glaucoma. Mouse models are often used to investigate the mechanisms controlling outflow facility, but the diminutive size of the mouse eye makes measurement of outflow technically challenging. In this study, we present a new approach to measure and analyse outflow facility using iPerfusion™, which incorporates an actuated pressure reservoir, thermal flow sensor, differential pressure measurement and an automated computerised interface. In enucleated eyes from C57BL/6J mice, the flow-pressure relationship is highly non-linear and is well represented by an empirical power law model that describes the pressure dependence of outflow facility. At zero pressure, the measured flow is indistinguishable from zero, confirming the absence of any significant pressure independent flow in enucleated eyes. Comparison with the commonly used 2-parameter linear outflow model reveals that inappropriate application of a linear fit to a non-linear flow-pressure relationship introduces considerable errors in the estimation of outflow facility and leads to the false impression of pressure-independent outflow. Data from a population of enucleated eyes from C57BL/6J mice show that outflow facility is best described by a lognormal distribution, with 6-fold variability between individuals, but with relatively tight correlation of facility between fellow eyes. iPerfusion represents a platform technology to accurately and robustly characterise the flow-pressure relationship in enucleated mouse eyes for the purpose of glaucoma research and with minor modifications, may be applied

  11. Respiratory tract and mediastinum

    International Nuclear Information System (INIS)

    Respiratory tract problems originating in attempts to diagnose and treat illness are commonplace. They range from pharyngeal trauma during intubation to radiation-induced thyroid carcinoma. Occasionally, as with pulmonary hypervolemia accompanying drug-induced renal failure, they originate at a distance. Their actual number far exceeds those brought to clinical attention. Familiarity with the procedures which give rise to these complications is helpful in detecting and remedying them. It is important, therefore, to discuss their pathogenesis as well as their clinical and radiological findings

  12. Standing Shocks around Black Holes and Estimation of Outflow Rates

    Indian Academy of Sciences (India)

    Santabrata Das; Sandip K. Chakrabarti

    2002-03-01

    We self-consistently obtain shock locations in an accretion flow by using an analytical method. One can obtain the spectral properties, quasi-periodic oscillation frequencies and the outflowrates when the inflow parameters are known. Since temperature of the CENBOL decides the spectral states of the black hole, and also the outflow rate, the outflow rate is directly related to the spectral states.

  13. Collective outflow from a small multiple stellar system

    International Nuclear Information System (INIS)

    The formation of high-mass stars is usually accompanied by powerful protostellar outflows. Such high-mass outflows are not simply scaled-up versions of their lower-mass counterparts, since observations suggest that the collimation degree degrades with stellar mass. Theoretically, the origins of massive outflows remain open to question because radiative feedback and fragmentation of the accretion flow around the most massive stars, with M > 15 M ☉, may impede the driving of magnetic disk winds. We here present a three-dimensional simulation of the early stages of core fragmentation and massive star formation that includes a subgrid-scale model for protostellar outflows. We find that stars that form in a common accretion flow tend to have aligned outflow axes, so that the individual jets of multiple stars can combine to form a collective outflow. We compare our simulation to observations with synthetic H2 and CO observations and find that the morphology and kinematics of such a collective outflow resembles some observed massive outflows, such as Cepheus A and DR 21. We finally compare physical quantities derived from simulated observations of our models to the actual values in the models to examine the reliability of standard methods for deriving physical quantities, demonstrating that those methods indeed recover the actual values to within a factor of two to three.

  14. Scaling Relations Between Warm Galactic Outflows and Their Host Galaxies

    CERN Document Server

    Chisholm, John; Leitherer, Claus; Chen, Yanmei; Wofford, Aida; Lundgren, Britt

    2014-01-01

    We report on a sample of 51 nearby, star-forming galaxies observed with the Cosmic Origin Spectrograph on the Hubble Space Telescope. We calculate Si II kinematics and densities arising from warm gas entrained in galactic outflows. We use multi-wavelength ancillary data to estimate stellar masses (M$_\\ast$), star-formation rates (SFR), and morphologies. We derive significant correlations between outflow velocity and SFR$^{\\sim 0.1}$, M$_\\ast^{\\sim 0.1}$ and v$_\\text{circ}^{\\sim 1/2}$. Some mergers drive outflows faster than these relations prescribe, launching the outflow faster than the escape velocity. Calculations of the mass outflow rate reveal strong scaling with SFR$^{\\sim 1/2}$ and M$_\\ast^{\\sim 1/2}$. Additionally, mass-loading efficiency factors (mass outflow rate divided by SFR) scale approximately as M$_\\ast^{-1/2}$. Both the outflow velocity and mass-loading scaling suggest that these outflows are powered by supernovae, with only 0.7% of the total supernovae energy converted into the kinetic energ...

  15. Diagnosis of urinary tract diseases

    International Nuclear Information System (INIS)

    Radiological exploration of the urinary tract has become highly sophisticated. The information provided by the new imaging techniques is extremely accurate and useful in the diagnosis and pretherapeutic assessment of most urinary tract diseases. Interventional radiology has given radiologists an important role in the treatment of some types of pathology. The authors describe the value of modern imaging and its different aspects in each of the principal branches of urinary tract pathology. viz.: tumours, obstructions, infections, vascular and prostatic diseases

  16. Simulation of Breach Outflow for Earthfill Dam

    Science.gov (United States)

    Razad, Azwin Zailti Abdul; Sabri Muda, Rahsidi; Mohd Sidek, Lariyah; Azia, Intan Shafilah Abdul; Hanum Mansor, Faezah; Yalit, Ruzaimei

    2013-06-01

    Dams have been built for many reasons such as irrigation, hydropower, flood mitigation, and water supply to support development for the benefit of human. However, the huge amount of water stored behind the dam can seriously pose adverse impacts to the downstream community should it be released due to unwanted dam break event. To minimise the potential loss of lives and property damages, a workable Emergency Response Plan is required to be developed. As part of a responsible dam owner and operator, TNB initiated a study on dam breach modelling for Cameron Highlands Hydroelectric Scheme to simulate the potential dam breach for Jor Dam. Prediction of dam breach parameters using the empirical equations of Froehlich and Macdonal-Langridge-Monopolis formed the basis of the modelling, coupled with MIKE 11 software to obtain the breach outflow due to Probable Maximum Flood (PMF). This paper will therefore discuss the model setup, simulation procedure and comparison of the prediction with existing equations.

  17. FIRE simulations: galactic outflows and their consequences

    Science.gov (United States)

    Keres, Dusan; FIRE team

    2016-06-01

    We study gaseous outflows and their consequences in high-resolution galaxy formation simulations with explicit stellar feedback from the Feedback in Realistic Environments project. Collective, galaxy scale, effect of stellar feedback results in episodic ejections of large amount of gas and heavy elements into the circum-galactic medium. Gas ejection episodes follow strong bursts of star formation. Properties of galactic star formation and ejection episodes depend on galaxy mass and redshift and, together with gas infall and recycling, shape the evolution of the circum-galactic medium and galaxies. As a consequence, our simulated galaxies have masses, star formation histories and heavy element content in good agreement with the observed population of galaxies.

  18. Propeller outflows from an MRI disc

    CERN Document Server

    Lii, Patrick S; Ustyugova, Galina V; Koldoba, Alexander V; Lovelace, Richard V E

    2013-01-01

    We present the results of axisymmetric simulations of MRI-driven accretion onto a rapidly rotating, magnetized star accreting in the propeller regime. The stellar magnetosphere corotates with the star, forming a centrifugal barrier at the disc-magnetosphere boundary which inhibits matter accretion onto the star. Instead, the disc matter accumulates at the disc-magnetosphere interface and slowly diffuses into the inner magnetosphere where it picks up angular momentum and is quickly ejected from the system as an outflow. Due to the interaction of the matter with the magnetosphere, this wind is discontinuous and is launched as discrete plasmoids. If the ejection rate is lower than the disc accretion rate, the matter accumulates at the disc-magnetosphere boundary faster than it can be ejected. In this case, accretion onto the star proceeds through the episodic accretion instability in which episodes of matter accumulation are followed by simultaneous accretion and ejection. During the accretion phase of this inst...

  19. Simulation of Breach Outflow for Earthfill Dam

    International Nuclear Information System (INIS)

    Dams have been built for many reasons such as irrigation, hydropower, flood mitigation, and water supply to support development for the benefit of human. However, the huge amount of water stored behind the dam can seriously pose adverse impacts to the downstream community should it be released due to unwanted dam break event. To minimise the potential loss of lives and property damages, a workable Emergency Response Plan is required to be developed. As part of a responsible dam owner and operator, TNB initiated a study on dam breach modelling for Cameron Highlands Hydroelectric Scheme to simulate the potential dam breach for Jor Dam. Prediction of dam breach parameters using the empirical equations of Froehlich and Macdonal-Langridge-Monopolis formed the basis of the modelling, coupled with MIKE 11 software to obtain the breach outflow due to Probable Maximum Flood (PMF). This paper will therefore discuss the model setup, simulation procedure and comparison of the prediction with existing equations.

  20. Cluster Formation in Protostellar Outflow-Driven Turbulence

    CERN Document Server

    Li, Z Y; Li, Zhi-Yun; Nakamura, Fumitaka

    2006-01-01

    Most, perhaps all, stars go through a phase of vigorous outflow during formation. We examine, through 3D MHD simulation, the effects of protostellar outflows on cluster formation. We find that the initial turbulence in the cluster-forming region is quickly replaced by motions generated by outflows. The protostellar outflow-driven turbulence (``protostellar turbulence'' for short) can keep the region close to a virial equilibrium long after the initial turbulence has decayed away. We argue that there exist two types of turbulence in star-forming clouds: a primordial (or ``interstellar'') turbulence and a protostellar turbulence, with the former transformed into the latter mostly in embedded clusters such as NGC 1333. Since the majority of stars are thought to form in clusters, an implication is that the stellar initial mass function is determined to a large extent by the stars themselves, through outflows which individually limit the mass accretion onto forming stars and collectively shape the environments (de...

  1. The Implications of Extreme Outflows from Extreme Starbursts

    CERN Document Server

    Heckman, Timothy M

    2016-01-01

    Interstellar ultraviolet absorption-lines provide crucial information about the properties of galactic outflows. In this paper, we augment our previous analysis of the systematic properties of starburst-driven galactic outflows by expanding our sample to include a rare population of starbursts with exceptionally high outflow velocities. In principle, these could be a qualitatively different phenomenon from more typical outflows. However, we find that instead these starbursts lie on, or along the extrapolation of, the trends defined by the more typical systems studied previously by us. We exploit the wide dynamic range provided by this new sample to determine scaling relations of outflow velocity with galaxy stellar mass (M*), circular velocity, star-formation rate (SFR), SFR/M*, and SFR/area. We argue that these results can be accommodated within the general interpretational framework we previously advocated, in which a population of ambient interstellar or circum-galactic clouds is accelerated by the combine...

  2. Searching for molecular outflows in Hyper-Luminous Infrared Galaxies

    CERN Document Server

    Calderón, D; Veilleux, S; Graciá-Carpio, J; Sturm, E; Lira, P; Schulze, S; Kim, S

    2016-01-01

    We present constraints on the molecular outflows in a sample of five Hyper-Luminous Infrared Galaxies using Herschel observations of the OH doublet at 119 {\\mu}m. We have detected the OH doublet in three cases: one purely in emission and two purely in absorption. The observed emission profile has a significant blueshifted wing suggesting the possibility of tracing an outflow. Out of the two absorption profiles, one seems to be consistent with the systemic velocity while the other clearly indicates the presence of a molecular outflow whose maximum velocity is about ~1500 km/s. Our analysis shows that this system is in general agreement with previous results on Ultra-luminous Infrared Galaxies and QSOs, whose outflow velocities do not seem to correlate with stellar masses or starburst luminosities (star formation rates). Instead the galaxy outflow likely arises from an embedded AGN.

  3. What Is Cardiac Rehabilitation?

    Science.gov (United States)

    ANSWERS by heart Treatments + Tests What Is Cardiac Rehabilitation? A cardiac rehabilitation (rehab) program takes place in a hospital or ... special help in making lifestyle changes. During your rehabilitation program you’ll… • Have a medical evaluation to ...

  4. Spitzer spectral line mapping of protostellar outflows: I. Basic data and outflow energetics

    CERN Document Server

    Neufeld, David A; Giannini, Teresa; Melnick, Gary J; Bergin, Edwin A; Yuan, Yuan; Maret, Sebastien; Tolls, Volker; Guesten, Rolf; Kaufman, Michael J

    2009-01-01

    We report the results of spectroscopic mapping observations carried out toward protostellar outflows in the BHR71, L1157, L1448, NGC 2071, and VLA 1623 molecular regions using the Infrared Spectrograph (IRS) of the Spitzer Space Telescope. These observations, covering the 5.2 - 37 micron spectral region, provide detailed maps of the 8 lowest pure rotational lines of molecular hydrogen and of the [SI] 25.25 micron and [FeII] 26.0 micron fine structure lines. The molecular hydrogen lines, believed to account for a large fraction of the radiative cooling from warm molecular gas that has been heated by a non-dissociative shock, allow the energetics of the outflows to be elucidated. Within the regions mapped towards these 5 outflow sources, total H2 luminosities ranging from 0.02 to 0.75 L(solar) were inferred for the sum of the 8 lowest pure rotational transitions. By contrast, the much weaker [FeII] 26.0 micron fine structure transition traces faster, dissociative shocks; here, only a small fraction of the fast ...

  5. Diffuse infiltrative cardiac tuberculosis

    International Nuclear Information System (INIS)

    We present the cardiac magnetic resonance images of an unusual form of cardiac tuberculosis. Nodular masses in a sheet-like distribution were seen to infiltrate the outer myocardium and pericardium along most of the cardiac chambers. The lesions showed significant resolution on antitubercular therapy

  6. Neonatal Staphylococcus lugdunensis urinary tract infection.

    Science.gov (United States)

    Hayakawa, Itaru; Hataya, Hiroshi; Yamanouchi, Hanako; Sakakibara, Hiroshi; Terakawa, Toshiro

    2015-08-01

    Staphylococcus lugdunensis is a known pathogen of infective endocarditis, but not of urinary tract infection. We report a previously healthy neonate without congenital anomalies of the kidney and urinary tract who developed urinary tract infection due to Staphylococcus lugdunensis, illustrating that Staphylococcus lugdunensis can cause urinary tract infection even in those with no urinary tract complications. PMID:26177232

  7. Molecular outflows driven by low-mass protostars. I. Correcting for underestimates when measuring outflow masses and dynamical properties

    Energy Technology Data Exchange (ETDEWEB)

    Dunham, Michael M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS 78, Cambridge, MA 02138 (United States); Arce, Héctor G. [Department of Astronomy, Yale University, P.O. Box 208101, New Haven, CT 06520 (United States); Mardones, Diego [Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago (Chile); Lee, Jeong-Eun [Department of Astronomy and Space Science, Kyung Hee University, Yongin, Gyeonggi 446-701 (Korea, Republic of); Matthews, Brenda C. [National Research Council of Canada, Herzberg Astronomy and Astrophysics, 5071 W. Saanich Road, Victoria, BC V9E 2E7 (Canada); Stutz, Amelia M. [Max-Planck-Institut für Astronomie, Königstuhl 17, D-69117, Heidelberg (Germany); Williams, Jonathan P., E-mail: mdunham@cfa.harvard.edu [Institute for Astronomy, University of Hawaii, Honolulu, HI 96822 (United States)

    2014-03-01

    We present a survey of 28 molecular outflows driven by low-mass protostars, all of which are sufficiently isolated spatially and/or kinematically to fully separate into individual outflows. Using a combination of new and archival data from several single-dish telescopes, 17 outflows are mapped in {sup 12}CO (2-1) and 17 are mapped in {sup 12}CO (3-2), with 6 mapped in both transitions. For each outflow, we calculate and tabulate the mass (M {sub flow}), momentum (P {sub flow}), kinetic energy (E {sub flow}), mechanical luminosity (L {sub flow}), and force (F {sub flow}) assuming optically thin emission in LTE at an excitation temperature, T {sub ex}, of 50 K. We show that all of the calculated properties are underestimated when calculated under these assumptions. Taken together, the effects of opacity, outflow emission at low velocities confused with ambient cloud emission, and emission below the sensitivities of the observations increase outflow masses and dynamical properties by an order of magnitude, on average, and factors of 50-90 in the most extreme cases. Different (and non-uniform) excitation temperatures, inclination effects, and dissociation of molecular gas will all work to further increase outflow properties. Molecular outflows are thus almost certainly more massive and energetic than commonly reported. Additionally, outflow properties are lower, on average, by almost an order of magnitude when calculated from the {sup 12}CO (3-2) maps compared to the {sup 12}CO (2-1) maps, even after accounting for different opacities, map sensitivities, and possible excitation temperature variations. It has recently been argued in the literature that the {sup 12}CO (3-2) line is subthermally excited in outflows, and our results support this finding.

  8. The gastrointestinal tract

    DEFF Research Database (Denmark)

    Bartels, Else M.; Harrison, Adrian Paul

    2009-01-01

    The gastrointestinal tract (GIT) has always been and remains a major source of interest in terms of both its function, and its malfunction. Our current knowledge of age-related changes in this system, as well as drug-food interactions, however, remains relatively limited. Paradoxically, the GIT is...... not one of the core battery of tests that pharmaceutical companies are obliged to investigate as part of drug development. This review aims to cover the basics of GIT function before highlighting aspects of relevance for safety pharmacology in terms of age, cancerogenesis, and noth drug and diet......-related GIT damage and dysfunction. New and novel aspects of drug delivery and drug-dietary supplement interactions are discusses and much needed areas of focus in terms of drug GIT testing are identified....

  9. Advances in alimentary tract imaging

    OpenAIRE

    Maglinte, Dean DT; Sandrasegaran, Kumaresan; Tann, Mark

    2006-01-01

    Advances in imaging techniques are changing the way radiologists undertake imaging of the gastrointestinal tract and their ability to answer questions posed by surgeons. In this paper we discuss the technological improvements of imaging studies that have occurred in the last few years and how these help to better diagnosing alimentary tract disease.

  10. The contribution of quasar outflows to cosmological structure formation

    Science.gov (United States)

    Arav, Nahum

    2011-10-01

    A vast new discovery space is opened up by the high sensitivity of COS in the far UV. These new capabilities are ushering a revolution in the study of AGN outflows. We now have the ability to obtain high quality data on objects up to a redshift of about 1, providing access to ten times more {and better} diagnostic absorption lines than was possible with STIS {which could only observe outflows at z<0.05 with sufficient S/N}. These diagnostics will allow us to quantify how much do quasar outflow contribute to AGN feedback. On the way to this lofty goal, we'll be able to resolve important questions in the study of these outflows: Where are they situated within the host galaxy? What is their ionization equilibrium and chemical abundances? Unlike ground-based observations, COS data can yield the answers to all these questions for the most ubiquitous outflows, and therefore connect them to our developing understanding of cosmological structure formation.Our analysis of recent archived COS observations gives a concrete example for the above claims; including the first determination of the distance from the central source for a high-ionization outflow. Here we propose an archive program to look through the 520 COS G130M and G160M orbits of AGN archive observations, identify quasar outflows and publish the analyses of the best cases.

  11. The role of cosmic ray pressure in accelerating galactic outflows

    CERN Document Server

    Simpson, Christine M; Marinacci, Federico; Pfrommer, Christoph; Springel, Volker; Glover, Simon C O; Clark, Paul C; Smith, Rowan J

    2016-01-01

    We study the formation of galactic outflows from supernova explosions (SNe) with the moving-mesh code AREPO in a stratified column of gas with a surface density similar to the Milky Way disk at the solar circle. We compare different simulation models for SNe placement and energy feedback, including cosmic rays (CR), and find that models that place SNe in dense gas and account for CR diffusion are able to drive outflows with similar mass loading as obtained from a random placement of SNe with no CRs. Despite this similarity, CR-driven outflows differ in several other key properties including their overall clumpiness and velocity. Moreover, the forces driving these outflows originate in different sources of pressure, with the CR diffusion model relying on non-thermal pressure gradients to create an outflow driven by internal pressure and the random-placement model depending on kinetic pressure gradients to propel a ballistic outflow. CRs therefore appear to be non-negligible physics in the formation of outflows...

  12. High-velocity molecular outflows hear massive young stellar objects

    Institute of Scientific and Technical Information of China (English)

    吴月芳; 李月兴; 杨传义; 雷成明; 孙金江; 吕静; 韩溥

    1999-01-01

    By mapping the 12CO J=1—0 lines in IRAS 05391-0217, 06114+1745 and 06291+0421, three new high-velocity bipolar molecular outflows are found. Parameters of these outflows are derived, which suggest that they are massive and energetic outflows with total kinetic energies of about 1038 J and mass loss rates about 10-5 M⊙/a. The driving sources are identified by analyzing the positions, intensities and color temperatures of the associated infrared sources. These outflows are most likely driven by single sources which correspond to massive young stellar objects. In these regions H2O masers have been detected located near the embedded infrared sources, which indicates that their exciting mechanism may be correlated with that of the CO outflows. The relationship between the parameters of outflows and central sources shows that high-velocity outflow and thermal radiation of a star are two basic correlated but different features in the evolution of young stars.

  13. Evolution of Protostellar Outflow around Low-mass Protostar

    CERN Document Server

    Machida, Masahiro N

    2013-01-01

    The evolution of protostellar outflow is investigated with resistive magneto-hydrodynamic nested-grid simulations that cover a wide range of spatial scales (\\sim 1AU - 1pc). We follow cloud evolution from the pre-stellar core stage until the infalling envelope dissipates long after the protostar formation. We also calculate protostellar evolution to derive protostellar luminosity with time-dependent mass accretion through a circumstellar disk. The protostellar outflow is driven by the first core prior to protostar formation and is directly driven by the circumstellar disk after protostar formation. The opening angle of the outflow is large in the Class 0 stage. A large fraction of the cloud mass is ejected in this stage, which reduces the star formation efficiency to \\sim 50%. After the outflow breaks out from the natal cloud, the outflow collimation is gradually improved in the Class I stage. The head of the outflow travels more than \\sim 10^5AU in \\sim 10^5 yr. The outflow momentum, energy and mass derived ...

  14. PROTOSTELLAR JETS ENCLOSED BY LOW-VELOCITY OUTFLOWS

    International Nuclear Information System (INIS)

    A protostellar jet and outflow are calculated for ∼270 yr following the protostar formation using a three-dimensional magnetohydrodynamics simulation, in which both the protostar and its parent cloud are spatially resolved. A high-velocity (∼100 km s–1) jet with good collimation is driven near the disk's inner edge, while a low-velocity (≲ 10 km s–1) outflow with a wide opening angle appears in the outer-disk region. The high-velocity jet propagates into the low-velocity outflow, forming a nested velocity structure in which a narrow high-velocity flow is enclosed by a wide low-velocity flow. The low-velocity outflow is in a nearly steady state, while the high-velocity jet appears intermittently. The time-variability of the jet is related to the episodic accretion from the disk onto the protostar, which is caused by gravitational instability and magnetic effects such as magnetic braking and magnetorotational instability. Although the high-velocity jet has a large kinetic energy, the mass and momentum of the jet are much smaller than those of the low-velocity outflow. A large fraction of the infalling gas is ejected by the low-velocity outflow. Thus, the low-velocity outflow actually has a more significant effect than the high-velocity jet in the very early phase of the star formation

  15. Suppression of galactic outflows by cosmological infall and circumgalactic medium

    CERN Document Server

    Singh, Priyanka; Bagla, Jasjeet S; Nath, Biman B

    2016-01-01

    We investigate the relative importance of two galactic outflow suppression mechanisms : a) Cosmological infall of the intergalactic gas onto the galaxy, and b) the existence of a hot circumgalactic medium (CGM). Considering only radial motion, the infall reduces the speed of outflowing gas and even halts the outflow, depending on the mass and redshift of the galaxy. For star forming galaxies there exists an upper mass limit beyond which outflows are suppressed by the gravitational field of the galaxy. We find that infall can reduce this upper mass limit approximately by a factor of two (independent of the redshift). Massive galaxies ($\\gtrsim 10^{12} M_{\\odot}$) host large reservoir of hot, diffuse CGM around the central part of the galaxy. The CGM acts as a barrier between the infalling and outflowing gas and provides an additional source of outflow suppression. We find that at low redshifts ($z\\lesssim3.5$), the CGM is more effective than the infall in suppressing the outflows. Together, these two processes...

  16. Isolated Fetal Ascite Associated with Cardiac Diseases

    Directory of Open Access Journals (Sweden)

    Vehbi Doğan

    2014-12-01

    Full Text Available Fetal ascite is defined as fluid accumulation in peritoneal cavity. It can be seen as isolated disease or an early sign of hydrops fetalis. Once fetal ascite is detected, a careful examination for hydops fetalis and possible underlying disease is necessary, since its prognosis and treatment depends mostly on the cause. Non-immunologic fetal ascite is an uncommon problem occurring for many reasons, such as urinary tract obstruction, congenital infections, genetic and metabolic diseases, gastrointestinal diseases and cardiovascular diseases. Here in this report we present two isolated fetal ascite that occurred secondary to cardiac diseases.

  17. Outflow and hot dust emission in broad absorption line quasars

    International Nuclear Information System (INIS)

    We have investigated a sample of 2099 broad absorption line (BAL) quasars with z = 1.7-2.2 built from the Sloan Digital Sky Survey Data Release Seven and the Wide-field Infrared Survey. This sample is collected from two BAL quasar samples in the literature and is refined by our new algorithm. Correlations of outflow velocity and strength with a hot dust indicator (βNIR) and other quasar physical parameters—such as an Eddington ratio, luminosity, and a UV continuum slope—are explored in order to figure out which parameters drive outflows. Here βNIR is the near-infrared continuum slope, which is a good indicator of the amount of hot dust emission relative to the accretion disk emission. We confirm previous findings that outflow properties moderately or weakly depend on the Eddington ratio, UV slope, and luminosity. For the first time, we report moderate and significant correlations of outflow strength and velocity with βNIR in BAL quasars. It is consistent with the behavior of blueshifted broad emission lines in non-BAL quasars. The statistical analysis and composite spectra study both reveal that outflow strength and velocity are more strongly correlated with βNIR than the Eddington ratio, luminosity, and UV slope. In particular, the composites show that the entire C IV absorption profile shifts blueward and broadens as βNIR increases, while the Eddington ratio and UV slope only affect the high and low velocity part of outflows, respectively. We discuss several potential processes and suggest that the dusty outflow scenario, i.e., that dust is intrinsic to outflows and may contribute to the outflow acceleration, is most likely.

  18. Contribution of alluvial groundwater to the outflow of mountainous catchments

    Science.gov (United States)

    Käser, Daniel; Hunkeler, Daniel

    2016-02-01

    Alluvial aquifers in mountainous regions cover typically a limited area. Their contribution to catchment storage and outflow is rarely isolated; alluvial groundwater discharge under gauging stations is generally assumed negligible; and hydrological models tend to lump alluvial storage with other units. The role of alluvial aquifers remains therefore unclear: can they contribute significantly to outflow when they cover a few percent of catchment area? Should they be considered a dynamic storage unit or merely a transmission zone? We address these issues based on the continuous monitoring of groundwater discharge, river discharge (one year), and aquifer storage (6 months) in the 6 km2 alluvial system of a 194 km2 catchment. River and groundwater outflow were measured jointly through "coupled gauging stations." The contribution of alluvial groundwater to outflow was highest at the outlet of a subcatchment (52 km2), where subsurface discharge amounted to 15% of mean annual outflow, and 85% of outflow during the last week of a drought. In this period, alluvial-aquifer depletion supported 75% of the subcatchment outflow and 35% of catchment outflow—thus 3% of the entire catchment supported a third of the outflow. Storage fluctuations occurred predominantly in the aquifer's upstream part, where heads varied over 6 m. Not only does this section act as a significant water source, but storage recovers also rapidly at the onset of precipitation. Storage dynamics were best conceptualized along the valley axis, rather than across the more conventional riparian-channel transect. Overall the contribution of alluvial aquifers to catchment outflow deserves more attention.

  19. Misalignment of Magnetic Fields and Outflows in Protostellar Cores

    CERN Document Server

    Hull, Charles L H; Bolatto, Alberto D; Bower, Geoffrey C; Carpenter, John M; Crutcher, Richard M; Fiege, Jason D; Franzmann, Erica; Hakobian, Nicholas S; Heiles, Carl; Houde, Martin; Hughes, A Meredith; Jameson, Katherine; Kwon, Woojin; Lamb, James W; Looney, Leslie W; Matthews, Brenda C; Mundy, Lee; Pillai, Thushara; Pound, Marc W; Stephens, Ian W; Tobin, John J; Vaillancourt, John E; Volgenau, N H; Wright, Melvyn C H

    2012-01-01

    Theoretical models of star formation generally assume that bipolar outflows are parallel to the mean magnetic-field direction in protostellar cores. Here we present results of \\lambda1.3 mm dust polarization observations toward 16 nearby, low-mass protostars, mapped with ~2.5" resolution at CARMA. The results show that magnetic fields in protostellar cores on scales of ~1000 AU are not tightly aligned with outflows from the protostars. If one assumes that outflows emerge along the rotation axes of circumstellar disks, then our results imply that these disks are not aligned with the fields in the cores from which they formed.

  20. Gravitational Microlensing and the Structure of Quasar Outflows

    CERN Document Server

    Chelouche, D

    2005-01-01

    We show that invaluable information on the structure of quasar outflows can be obtained by considering microlensing (ML) induced variability of absorption line troughs in lensed quasars. Depending on the structure and geometry of the outflowing gas, such extrinsic line variability can be manifested as changes to the equivalent width of the line as well as line profile distortions. Here we consider several physically distinct outflow models, having very similar spectral predictions, and show how ML induced absorption line variability can be used to distinguish between them. The merits of future systematic studies of these effects are exemplified.

  1. Cardiac tumours in children

    Directory of Open Access Journals (Sweden)

    Parsons Jonathan M

    2007-03-01

    Full Text Available Abstract Cardiac tumours are benign or malignant neoplasms arising primarily in the inner lining, muscle layer, or the surrounding pericardium of the heart. They can be primary or metastatic. Primary cardiac tumours are rare in paediatric practice with a prevalence of 0.0017 to 0.28 in autopsy series. In contrast, the incidence of cardiac tumours during foetal life has been reported to be approximately 0.14%. The vast majority of primary cardiac tumours in children are benign, whilst approximately 10% are malignant. Secondary malignant tumours are 10–20 times more prevalent than primary malignant tumours. Rhabdomyoma is the most common cardiac tumour during foetal life and childhood. It accounts for more than 60% of all primary cardiac tumours. The frequency and type of cardiac tumours in adults differ from those in children with 75% being benign and 25% being malignant. Myxomas are the most common primary tumours in adults constituting 40% of benign tumours. Sarcomas make up 75% of malignant cardiac masses. Echocardiography, Computing Tomography (CT and Magnetic Resonance Imaging (MRI of the heart are the main non-invasive diagnostic tools. Cardiac catheterisation is seldom necessary. Tumour biopsy with histological assessment remains the gold standard for confirmation of the diagnosis. Surgical resection of primary cardiac tumours should be considered to relieve symptoms and mechanical obstruction to blood flow. The outcome of surgical resection in symptomatic, non-myxomatous benign cardiac tumours is favourable. Patients with primary cardiac malignancies may benefit from palliative surgery but this approach should not be recommended for patients with metastatic cardiac tumours. Surgery, chemotherapy and radiotherapy may prolong survival. The prognosis for malignant primary cardiac tumours is generally extremely poor.

  2. Dissipation in Relativistic Outflows: A Multisource Overview

    CERN Document Server

    Thompson, Christopher

    2013-01-01

    Relativistically expanding sources of X-rays and gamma-rays cover an enormous range of (central) compactness and Lorentz factor. The underlying physics is discussed, with an emphasis on how the dominant dissipative mode and the emergent spectrum depend on these parameters. Photons advected outward from high optical depth are a potentially important source of Compton seeds. Their characteristic energy is bounded below by ~1 MeV in pair-loaded outflows of relatively low compactness, and remains near ~1 MeV at very high compactness and low matter loading. This is compared with the characteristic energy of O(1) MeV observed in the rest frame spectra of many sources, including gamma-ray bursts, OSSE jet sources, MeV Blazars, and the intense initial 0.1 s pulse of the March 5 event. Additional topics discussed include the feedback of pair creation on electron heating and the formation of non-thermal spectra, their effectiveness at shielding the dissipative zone from ambient photons, direct Compton damping of irregu...

  3. Radiation Transport for Explosive Outflows: Opacity Regrouping

    CERN Document Server

    Wollaeger, Ryan T

    2014-01-01

    Implicit Monte Carlo (IMC) and Discrete Diffusion Monte Carlo (DDMC) are methods used to stochastically solve the radiative transport and diffusion equations, respectively. These methods combine into a hybrid transport-diffusion method we refer to as IMC-DDMC. We explore a multigroup IMC-DDMC scheme that, in DDMC, combines frequency groups with sufficient optical thickness. We term this procedure "opacity regrouping". Opacity regrouping has previously been applied to IMC-DDMC calculations for problems in which the dependence of the opacity on frequency is monotonic. We generalize opacity regrouping to non-contiguous groups and implement this in \\supernu, a code designed to do radiation transport in high-velocity outflows with non-monotonic opacities. We find that regrouping of non-contiguous opacity groups generally improves the speed of IMC-DDMC radiation transport. We present an asymptotic analysis that informs the nature of the Doppler shift in DDMC groups and summarize the derivation of the Gentile-Fleck ...

  4. Optically thick outflows in ultraluminous supersoft sources

    CERN Document Server

    Urquhart, Ryan

    2015-01-01

    Ultraluminous supersoft sources (ULSs) are defined by a thermal spectrum with colour temperatures ~0.1 keV, bolometric luminosities ~ a few 10^39 erg/s, and almost no emission above 1 keV. It has never been clear how they fit into the general scheme of accreting compact objects. To address this problem, we studied a sample of seven ULSs with extensive Chandra and XMM-Newton coverage. We find an anticorrelation between fitted temperatures and radii of the thermal emitter, and no correlation between bolometric luminosity and radius or temperature. We compare the physical parameters of ULSs with those of classical supersoft sources, thought to be surface-nuclear-burning white dwarfs, and of ultraluminous X-ray sources (ULXs), thought to be super-Eddington stellar-mass black holes. We argue that ULSs are the sub-class of ULXs seen through the densest wind, perhaps an extension of the soft-ultraluminous regime. We suggest that in ULSs, the massive disk outflow becomes effectively optically thick and forms a large ...

  5. Indirect measurement of Delta outflow using ultrasonic velocity meters and comparison with mass-balance calculated outflow

    Science.gov (United States)

    Oltmann, Richard N.

    1998-01-01

    A measurement of the quantity of water flowing from the Sacramento-San Joaquin Delta into Suisun Bay (Delta outflow) has been desired by those studying and managing the San Francisco Bay/Delta estuary since the 1920s.  Historically, Delta outflow has been estimated using a mass-balance calculation that uses measured Delta inflows and exports, and imprecise estimates of consumptive use for the approximately 2,000 small agricultural diversions with the Delta.  The DWR has estimated Delta outflow for 1929 to present using the computer program DAYFLOW.

  6. Stimulating endogenous cardiac regeneration

    Directory of Open Access Journals (Sweden)

    Amanda eFinan

    2015-09-01

    Full Text Available The healthy adult heart has a low turnover of cardiac myocytes. The renewal capacity, however, is augmented after cardiac injury. Participants in cardiac regeneration include cardiac myocytes themselves, cardiac progenitor cells, and peripheral stem cells, particularly from the bone marrow compartment. Cardiac progenitor cells and bone marrow stem cells are augmented after cardiac injury, migrate to the myocardium, and support regeneration. Depletion studies of these populations have demonstrated their necessary role in cardiac repair. However, the potential of these cells to completely regenerate the heart is limited. Efforts are now being focused on ways to augment these natural pathways to improve cardiac healing, primarily after ischemic injury but in other cardiac pathologies as well. Cell and gene therapy or pharmacological interventions are proposed mechanisms. Cell therapy has demonstrated modest results and has passed into clinical trials. However, the beneficial effects of cell therapy have primarily been their ability to produce paracrine effects on the cardiac tissue and recruit endogenous stem cell populations as opposed to direct cardiac regeneration. Gene therapy efforts have focused on prolonging or reactivating natural signaling pathways. Positive results have been demonstrated to activate the endogenous stem cell populations and are currently being tested in clinical trials. A potential new avenue may be to refine pharmacological treatments that are currently in place in the clinic. Evidence is mounting that drugs such as statins or beta blockers may alter endogenous stem cell activity. Understanding the effects of these drugs on stem cell repair while keeping in mind their primary function may strike a balance in myocardial healing. To maximize endogenous cardiac regeneration,a combination of these approaches couldameliorate the overall repair process to incorporate the participation ofmultiple cell players.

  7. Nucleosynthesis in Outflows from the Inner Regions of Collapsars

    CERN Document Server

    Pruet, J; Hoffman, R D; Pruet, Jason; Thompson, Todd

    2004-01-01

    We consider nucleosynthesis in outflows originating from the inner regions of viscous accretion disks formed after the collapse of a rotating massive star. We show that wind-like outflows driven by viscous and neutrino heating can efficiently synthesize Fe-group elements moving at near-relativistic velocities. The mass of 56Ni synthesized and the asymptotic velocities attained in our calculations are in accord with those inferred from observations of SN1998bw and SN2003dh. These steady wind-like outflows are generally proton rich, characterized by only modest entropies, and consequently synthesize essentially nothing heavier than the Fe-group elements. We also discuss bubble-like outflows resulting from rapid energy deposition in localized regions near or in the accretion disk. These intermittent ejecta emerge with low electron fraction and are a promising site for the synthesis of the A=130 r-process peak elements.

  8. Effects of Outflow Area on Pool Boiling in Vertical Annulus

    International Nuclear Information System (INIS)

    To identify the effects of an outflow area on pool boiling heat transfer in a vertical annulus, three different flow recreates were studied experimentally. For the test, a heated tube of smooth stainless steel and water at atmospheric pressure were used. Both annuli with open and closed bottoms were considered. To validate the effects of the outflow area on the heat transfer, the results of the annulus with the reactors were compared with the data for the plain annulus without the reactors. The reduction of the outflow area ultimately results in a decrease in the heat transfer. As the outflow area is very small, a slight increase in heat transfer is also observed. The major cause of this tendency is explained as the difference in the intensity of liquid agitation cause by the movement of coalesced bubbles. It is identified that the convective flow, pulsating flow, and evaporative mechanism are considered as the important mechanisms

  9. Estimation of cold plasma outflow during geomagnetic storms

    CERN Document Server

    Haaland, S; André, M; Maes, L; Baddeley, L; Barakat, A; Chappell, R; Eccles, V; Johnsen, C; Lybekk, B; Li, K; Pedersen, A; Schunk, R; Welling, D

    2016-01-01

    Low-energy ions of ionospheric origin constitute a significant contributor to the magnetospheric plasma population. Measuring cold ions is difficult though. Observations have to be done at sufficiently high altitudes and typically in regions of space where spacecraft attain a positive charge due to solar illumination. Cold ions are therefore shielded from the satellite particle detectors. Furthermore, spacecraft can only cover key regions of ion outflow during segments of their orbit, so additional complications arise if continuous longtime observations, such as during a geomagnetic storm, are needed. In this paper we suggest a new approach, based on a combination of synoptic observations and a novel technique to estimate the flux and total outflow during the various phases of geomagnetic storms. Our results indicate large variations in both outflow rates and transport throughout the storm. Prior to the storm main phase, outflow rates are moderate, and the cold ions are mainly emanating from moderately sized ...

  10. About the seasonal and fortnightly variabilities of the Mediterranean outflow

    Directory of Open Access Journals (Sweden)

    C. Millot

    2011-06-01

    Full Text Available CTD time series from the HYDRO-CHANGES programme and INGRES projects have been collected simultaneously (2004–2008 on the shelf of Morocco and at the sills of Camarinal and Espartel in the strait of Gibraltar. They provide information that supports results recently obtained from the analysis of the two former time series, as well as from a reanalysis of GIBEX CTD profiles (1985–1986. The outflow of Mediterranean Waters, which does not show a clear seasonal variability before entering the strait, strongly mixes within the strait, due mainly to the internal tide, with the seasonally variable inflow of Atlantic Water. The outflow thus gets marked seasonal and fortnightly variabilities within the strait. Furthermore, since the outflowing waters entering the strait display marked spatial heterogeneity and long-term temporal variabilities, accurately predicting the characteristics of the Mediterranean outflow into the North Atlantic Ocean appears almost impossible.

  11. Population-based evaluation of a suggested anatomic and clinical classification of congenital heart defects based on the International Paediatric and Congenital Cardiac Code

    Directory of Open Access Journals (Sweden)

    Goffinet François

    2011-10-01

    Full Text Available Abstract Background Classification of the overall spectrum of congenital heart defects (CHD has always been challenging, in part because of the diversity of the cardiac phenotypes, but also because of the oft-complex associations. The purpose of our study was to establish a comprehensive and easy-to-use classification of CHD for clinical and epidemiological studies based on the long list of the International Paediatric and Congenital Cardiac Code (IPCCC. Methods We coded each individual malformation using six-digit codes from the long list of IPCCC. We then regrouped all lesions into 10 categories and 23 subcategories according to a multi-dimensional approach encompassing anatomic, diagnostic and therapeutic criteria. This anatomic and clinical classification of congenital heart disease (ACC-CHD was then applied to data acquired from a population-based cohort of patients with CHD in France, made up of 2867 cases (82% live births, 1.8% stillbirths and 16.2% pregnancy terminations. Results The majority of cases (79.5% could be identified with a single IPCCC code. The category "Heterotaxy, including isomerism and mirror-imagery" was the only one that typically required more than one code for identification of cases. The two largest categories were "ventricular septal defects" (52% and "anomalies of the outflow tracts and arterial valves" (20% of cases. Conclusion Our proposed classification is not new, but rather a regrouping of the known spectrum of CHD into a manageable number of categories based on anatomic and clinical criteria. The classification is designed to use the code numbers of the long list of IPCCC but can accommodate ICD-10 codes. Its exhaustiveness, simplicity, and anatomic basis make it useful for clinical and epidemiologic studies, including those aimed at assessment of risk factors and outcomes.

  12. Ultra Fast Outflows: Galaxy-Scale Active Galactic Nucleus Feedback

    OpenAIRE

    Wagner, A. Y.; Umemura, M; Bicknell, G. V.

    2012-01-01

    We show, using global 3D grid-based hydrodynamical simulations, that Ultra Fast Outflows (UFOs) from Active Galactic Nuclei (AGN) result in considerable feedback of energy and momentum into the interstellar medium (ISM) of the host galaxy. The AGN wind interacts strongly with the inhomogeneous, two-phase ISM consisting of dense clouds embedded in a tenuous hot hydrostatic medium. The outflow floods through the inter-cloud channels, sweeps up the hot ISM, and ablates and disperses the dense cl...

  13. Ultra-fast outflows (aka UFOs) from AGNs and QSOs

    Science.gov (United States)

    Cappi, M.; Tombesi, F.; Giustini, M.

    During the last decade, strong observational evidence has been accumulated for the existence of massive, high velocity winds/outflows (aka Ultra Fast Outflows, UFOs) in nearby AGNs and in more distant quasars. Here we briefly review some of the most recent developments in this field and discuss the relevance of UFOs for both understanding the physics of accretion disk winds in AGNs, and for quantifying the global amount of AGN feedback on the surrounding medium.

  14. Searching for molecular outflows in Hyper-Luminous Infrared Galaxies

    OpenAIRE

    D. Calderón; Bauer, F. E.; Veilleux, S; Graciá-Carpio, J; Sturm, E; P. Lira; Schulze, S.; Kim, S.

    2016-01-01

    We present constraints on the molecular outflows in a sample of five Hyper-Luminous Infrared Galaxies using Herschel observations of the OH doublet at 119 {\\mu}m. We have detected the OH doublet in three cases: one purely in emission and two purely in absorption. The observed emission profile has a significant blueshifted wing suggesting the possibility of tracing an outflow. Out of the two absorption profiles, one seems to be consistent with the systemic velocity while the other clearly indi...

  15. Characterization of molecular outflows in the substellar domain

    Energy Technology Data Exchange (ETDEWEB)

    Phan-Bao, Ngoc; Dang-Duc, Cuong [Department of Physics, International University-Vietnam National University HCM, Block 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City (Viet Nam); Lee, Chin-Fei; Ho, Paul T. P. [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 106, Taiwan (China); Li, Di, E-mail: pbngoc@hcmiu.edu.vn, E-mail: pbngoc@asiaa.sinica.edu.tw [National Astronomical Observatories, Chinese Academy of Science, Chaoyang District Datun Rd A20, Beijing (China)

    2014-11-01

    We report here our latest search for molecular outflows from young brown dwarfs and very low-mass stars in nearby star-forming regions. We have observed three sources in Taurus with the Submillimeter Array and the Combined Array for Research in Millimeter-wave Astronomy at 230 GHz frequency to search for CO J = 2 → 1 outflows. We obtain a tentative detection of a redshifted and extended gas lobe at about 10 arcsec from the source GM Tau, a young brown dwarf in Taurus with an estimated mass of 73 M {sub J}, which is right below the hydrogen-burning limit. No blueshifted emission around the brown dwarf position is detected. The redshifted gas lobe that is elongated in the northeast direction suggests a possible bipolar outflow from the source with a position angle of about 36°. Assuming that the redshifted emission is outflow emission from GM Tau, we then estimate a molecular outflow mass in the range from 1.9 × 10{sup –6} M {sub ☉} to 2.9 × 10{sup –5} M {sub ☉} and an outflow mass-loss rate from 2.7 × 10{sup –9} M {sub ☉} yr{sup –1} to 4.1 × 10{sup –8} M {sub ☉} yr{sup –1}. These values are comparable to those we have observed in the young brown dwarf ISO-Oph 102 of 60 M {sub J} in ρ Ophiuchi and the very low-mass star MHO 5 of 90 M {sub J} in Taurus. Our results suggest that the outflow process in very low-mass objects is episodic with a duration of a few thousand years and the outflow rate of active episodes does not significantly change for different stages of the formation process of very low-mass objects. This may provide us with important implications that clarify the formation process of brown dwarfs.

  16. Ultra-fast outflows (aka UFOs) from AGNs and QSOs

    CERN Document Server

    Cappi, M; Giustini, M

    2013-01-01

    During the last decade, strong observational evidence has been accumulated for the existence of massive, high velocity winds/outflows (aka Ultra Fast Outflows, UFOs) in nearby AGNs and in more distant quasars. Here we briefly review some of the most recent developments in this field and discuss the relevance of UFOs for both understanding the physics of accretion disk winds in AGNs, and for quantifying the global amount of AGN feedback on the surrounding medium.

  17. Identifying the Main Driver of Active Region Outflows

    Science.gov (United States)

    Baker, D.; van Driel-Gesztelyi, L.; Mandrini, C. H.; Démoulin, P.; Murray, M. J.

    2012-08-01

    Hinode's EUV Imaging Spectrometer (EIS) has discovered ubiquitous outflows of a few to 50 km s-1 from active regions (ARs). The characteristics of these outflows are very curious in that they are most prominent at the AR boundary and appear over monopolar magnetic areas. They are linked to strong non-thermal line broadening and are stronger in hotter EUV lines. The outflows persist for at least several days. Whereas red-shifted down flows observed in AR closed loops are well understood, to date there is no general consensus for the mechanism(s) driving blue-shifted AR-related outflows. We use Hinode EIS and X-Ray Telescope observations of AR 10942 coupled with magnetic modeling to demonstrate for the first time that the outflows originate from specific locations of the magnetic topology where field lines display strong gradients of magnetic connectivity, namely quasi-separatrix layers (QSLs), or in the limit of infinitely thin QSLs, separatrices. The strongest AR outflows were found to be in the vicinity of QSL sections located over areas of strong magnetic field. We argue that magnetic reconnection at QSLs, separating closed field lines of the AR and either large-scale externally connected or ‘open’ field lines, is a viable mechanism for driving AR outflows which are potentially sources of the slow solar wind. In fact, magnetic reconnection along QSLs (including separatricies) is the first theory to explain the most puzzling characteristics of the outflows, namely their occurrence over monopolar areas at the periphery of ARs and their longevity.

  18. Capital Outflow Controls and Income Distribution in Malaysia

    OpenAIRE

    Jarita Duasa

    2008-01-01

    The study seeks to analyze the impact of capital outflow controls, imposed by Malaysian government on September 1998, on income distribution. Regression analysis using OLS (Ordinary Least Square), 2SLS (Two Stages Least Square) and GMM (Generalised Method of Moment) methods of estimation reveals that the capital outflow controls reduce inequality of income distribution in the country. The controls are believed to result in improvement of export-led industries, through devaluation from control...

  19. Advection-Dominated Accretion with Infall and Outflows

    OpenAIRE

    Beckert, Thomas

    2000-01-01

    We present self-similar solutions for advection-dominated accretion flows with radial viscous force in the presence of outflows from the accretion flow or infall. The axisymmetric flow is treated in variables integrated over polar sections and the effects of infall and outflows on the accretion flow are parametrised for possible configurations compatible with the self-similar solution. We investigate the resulting accretion flows for three different viscosity laws and derive upper limits on t...

  20. Fast outflows and star formation quenching in quasar host galaxies

    Science.gov (United States)

    Carniani, S.; Marconi, A.; Maiolino, R.; Balmaverde, B.; Brusa, M.; Cano-Díaz, M.; Cicone, C.; Comastri, A.; Cresci, G.; Fiore, F.; Feruglio, C.; La Franca, F.; Mainieri, V.; Mannucci, F.; Nagao, T.; Netzer, H.; Piconcelli, E.; Risaliti, G.; Schneider, R.; Shemmer, O.

    2016-06-01

    Negative feedback from active galactic nuclei (AGN) is considered a key mechanism in shaping galaxy evolution. Fast, extended outflows are frequently detected in the AGN host galaxies at all redshifts and luminosities, both in ionised and molecular gas. However, these outflows are only potentially able to quench star formation, and we are still lacking decisive evidence of negative feedback in action. Here we present observations obtained with the Spectrograph for INtegral Field Observations in the Near Infrared (SINFONI) H- and K-band integral-field of two quasars at z ~ 2.4 that are characterised by fast, extended outflows detected through the [Oiii]λ5007 line. The high signal-to-noise ratio of our observations allows us to identify faint narrow (FWHManti-correlated with the fast outflows. The ionised outflows therefore appear to be able to suppress star formation in the region where the outflow is expanding. However, the detection of narrow spatially extended Hα emission indicates star formation rates of at least ~50-90 M⊙ yr-1, suggesting either that AGN feedback does not affect the whole galaxy or that many feedback episodes are required before star formation is completely quenched. On the other hand, the narrow Hα emission extending along the edges of the outflow cone may also lead also to a positive feedback interpretation. Our results highlight the possible double role of galaxy-wide outflows in host galaxy evolution. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile, P.ID: 086.B-0579(A) and 091.A-0261(A).The reduced data cubes are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/591/A28

  1. Pharmacological characterization of ergotamine-induced inhibition of the cardioaccelerator sympathetic outflow in pithed rats.

    Science.gov (United States)

    Cobos-Puc, Luis E; Villalón, Carlos M; Sánchez-López, Araceli; Ramírez-Rosas, Martha B; Lozano-Cuenca, Jair; Pertz, Heinz H; Görnemann, Tilo; Centurión, David

    2009-02-01

    Ergotamine inhibits the sympathetically-induced tachycardia in pithed rats. The present study identified the pharmacological profile of this response. Male Wistar rats were pithed and prepared to stimulate the preganglionic (C(7)-T(1)) cardiac sympathetic outflow. Intravenous continuous infusions of ergotamine dose-dependently inhibited the tachycardic responses to sympathetic stimulation, but not those to exogenous noradrenaline. Using several antagonists, the sympatho-inhibition to ergotamine was: (1) partially blocked by rauwolscine (alpha(2)), haloperidol (D(1/2)-like) or rauwolscine plus GR127935 (5-HT(1B/1D)); (2) abolished by rauwolscine plus haloperidol; and (3) unaffected by either saline or GR127935. In animals systematically pretreated with haloperidol, this sympatho-inhibition was: (1) unaffected by BRL44408 (alpha(2A)), partially antagonized by MK912 (alpha(2C)); and (3) abolished by BRL44408 plus MK912. These antagonists failed to modify the sympathetically induced tachycardic responses per se. Thus, the cardiac sympatho-inhibition by ergotamine may be mainly mediated by alpha(2A)/alpha(2C)-adrenoceptors, D(2)-like receptors and, to a lesser extent, by 5-HT(1B/1D) receptors. PMID:18779954

  2. Exercise-induced intra-ventricular gradients as a frequent potential cause of myocardial ischemia in cardiac syndrome X patients

    Directory of Open Access Journals (Sweden)

    Almeida Ana G

    2008-01-01

    Full Text Available Abstract Background The development of intra-ventricular gradients (IVG during dobutamine or exercise stress is not infrequent, and can be associated to symptoms during stress. The purpose of this study was to assess the occurrence of IVG during exercise stress echocardiography in cardiac syndrome X patients. Methods We prospectively evaluated 91 patients (pts mean aged 51 ± 12 years (age ranged 20 to 75 years old, 44 of whom were women. All pts had angina, positive exercise ECG treadmill testing, normal rest echocardiogram and no coronary artery disease on coronary angiogram (cardiac X syndrome. After complete Doppler echocardiographic evaluation with determination of left ventricular outflow tract index (LVOTi, relative left ventricular wall thickness (RLVWT and left ventricular end-diastolic volume index (LVDVi, all patients underwent stress echocardiography with two-dimensional and Doppler echographic evaluation during and after treadmill exercise. Results For analysis purpose patients were divided in 2 groups, according to the development of IVG. Doppler evidence of IVG was found in 33 (36% of the patients (Group A, with mean age 47 ± 14 years old (age ranged 20 to 72 years and with a mean end-systolic peak gradient of 86 ± 34 mmHg (ranging from 30 to 165 mmHg. The IVG development was accompanied by SAM of the mitral valve in 23 pts. Three of these pts experienced symptomatic hypotension. Ten were women (30% pts. 58 pts in group B, 34 of whom were women (59% (p = 0,01 vs group A, mean aged 53,5 ± 10,9 years old (age ranged 34 to 75 years (p = 0,03 vs group A, did not develop IVG. LVOTi was 10,29 ± 0,9 mm/m2 in group A and 11,4 ± 1 mm/m2 in group B (p 2 in group A and 56 ± 11,6 ml/m2 in group B (p = 0,000. Conclusion 1. A significant number of patients with cardiac X syndrome developed IVG during upright exercise in treadmill. These pts (group A are mainly males and younger than those who did not develop IVG. 2. The development of IVG

  3. Tracing outflows in the AGN forbidden region with SINFONI

    CERN Document Server

    Kakkad, D; Padovani, P; Cresci, G; Husemann, B; Carniani, S; Brusa, M; Lamastra, A; Lanzuisi, G; Piconcelli, E; Schramm, M

    2016-01-01

    AGN driven outflows are invoked in numerical simulations to reproduce several observed properties of local galaxies. The z > 1 epoch is of particular interest as it was during this time that the volume averaged star formation and the accretion rate of black holes were maximum. Radiatively driven outflows are therefore believed to be common during this epoch. We aim to trace and characterize outflows in AGN hosts with high mass accretion rates at z > 1 using integral field spectroscopy. We obtain spatially-resolved kinematics of the [OIII]5007 line in two targets which reveal the morphology and spatial extension of the outflows. We present J and H+K band SINFONI observations of 5 AGNs at 1.2 < z < 2.2. To maximize the chance of observing radiatively driven outflows, our sample was pre-selected based on peculiar values of the Eddington ratio and the hydrogen column density of the surrounding interstellar medium. We observe high velocity (~600-1900 km/s) and kiloparsec scale extended ionized outflows in at...

  4. The Implications of Extreme Outflows from Extreme Starbursts

    Science.gov (United States)

    Heckman, Timothy M.; Borthakur, Sanchayeeta

    2016-05-01

    Interstellar ultraviolet absorption lines provide crucial information about the properties of galactic outflows. In this paper, we augment our previous analysis of the systematic properties of starburst-driven galactic outflows by expanding our sample to include a rare population of starbursts with exceptionally high outflow velocities. In principle, these could be a qualitatively different phenomenon from more typical outflows. However, we find that instead these starbursts lie on, or along the extrapolation of, the trends defined by the more typical systems studied previously by us. We exploit the wide dynamic range provided by this new sample to determine scaling relations of outflow velocity with galaxy stellar mass (M *), circular velocity, star formation rate (SFR), SFR/M *, and SFR/area. We argue that these results can be accommodated within the general interpretational framework we previously advocated, in which a population of ambient interstellar or circumgalactic clouds is accelerated by the combined forces of gravity and the momentum flux from the starburst. We show that this simple physical picture is consistent with both the strong cosmological evolution of galactic outflows in typical star-forming galaxies and the paucity of such galaxies with spectra showing inflows. We also present simple parameterizations of these results that can be implemented in theoretical models and numerical simulations of galaxy evolution.

  5. A distance limited sample of massive molecular outflows

    CERN Document Server

    Maud, L T; Lumsden, S L; Mottram, J C; Urquhart, J S; Hoare, M G

    2015-01-01

    We have observed 99 mid-infrared-bright, massive young stellar objects and compact HII regions drawn from the Red MSX source (RMS) survey in the J=3$-$2 transition of $^{12}$CO and $^{13}$CO, using the James Clerk Maxwell Telescope. 89 targets are within 6 kpc of the Sun, covering a representative range of luminosities and core masses. These constitute a relatively unbiased sample of bipolar molecular outflows associated with massive star formation. Of these, 59, 17 and 13 sources (66, 19 and 15 percent) are found to have outflows, show some evidence of outflow, and have no evidence of outflow, respectively. The time-dependent parameters of the high-velocity molecular flows are calculated using a spatially variable dynamic timescale. The canonical correlations between the outflow parameters and source luminosity are recovered and shown to scale with those of low-mass sources. For coeval star formation we find the scaling is consistent with all the protostars in an embedded cluster providing the outflow force,...

  6. Evolution of active region outflows throughout an active region lifetime

    CERN Document Server

    Zangrilli, L

    2016-01-01

    We have shown previously that SOHO/UVCS data allow us to detect active region (AR) outflows at coronal altitudes higher than those reached by other instrumentation. These outflows are thought to be a component of the slow solar wind. Our purpose is to study the evolution of the outflows in the intermediate corona from AR 8100, from the time the AR first forms until it dissolves, after several transits at the solar limb. Data acquired by SOHO/UVCS at the time of the AR limb transits, at medium latitudes and at altitudes ranging from 1.5 to 2.3 R_sun, were used to infer the physical properties of the outflows through the AR evolution. To this end, we applied the Doppler dimming technique to UVCS spectra. These spectra include the H I Lyman alpha line and the O VI doublet lines at 1031.9 and 1037.6 A. Plasma speeds and electron densities of the outflows were inferred over several rotations of the Sun. AR outflows are present in the newly born AR and persist throughout the entire AR life. Moreover, we found two t...

  7. Discovery of Relativistic Outflow in the Seyfert Galaxy Ark 564

    CERN Document Server

    Gupta, A; Krongold, Y; Nicastro, F

    2013-01-01

    We present Chandra high energy transmission grating spectra of the narrow-line Seyfert-1 galaxy Ark 564. The spectrum shows numerous absorption lines which are well modeled with low velocity outflow components usually observed in Seyfert galaxies (Gupta et al. 2013). There are, however, some residual absorption lines which are not accounted for by low-velocity outflows. Here we present identifications of the strongest lines as K{\\alpha} transitions of OVII(two lines) and OVI at outflow velocities of ~0.1c. These lines are detected at 6.9{\\sigma}, 6.2{\\sigma}, and 4.7{\\sigma} respectively and cannot be due to chance statistical fluctuations. Photoionization models with ultra-high velocity components improves the spectral fit significantly, providing further support for the presence of relativistic outflow in this source. Without knowing the location of the absorber, its mass and energy outflow rates cannot be well constrained; we find E$\\dot{E}(outflow)/L_{bo}$ ranging from < 0.001% to 60% using different a...

  8. Characterization of Molecular Outflows in The Substellar Domain

    CERN Document Server

    Phan-Bao, Ngoc; Ho, Paul T P; Dang-Duc, Cuong; Li, Di

    2014-01-01

    We report here our latest search for molecular outflows from young brown dwarfs and very low-mass stars in nearby star-forming regions. We have observed three sources in Taurus with the Submillimeter Array and the Combined Array for Research in Millimeter-wave Astronomy at 230 GHz frequency to search for CO J=2-1 outflows. We obtain a tentative detection of a redshifted and extended gas lobe at about 10 arcsec from the source GM Tau, a young brown dwarf in Taurus with an estimated mass of 73 M_J, which is right below the hydrogen-burning limit. No blueshifted emission around the brown dwarf position is detected. The redshifted gas lobe that is elongated in the northeast direction suggests a possible bipolar outflow from the source with a position angle of about 36 degrees. Assuming that the redshifted emission is outflow emission from GM Tau, we then estimate a molecular outflow mass in the range from 1.9x10^-6 M_Sun to 2.9x10^-5 M_Sun and an outflow mass-loss rate from 2.7x10^-9 M_Sun yr^-1 to 4.1x10^-8 M_Su...

  9. Energy- and momentum-conserving AGN feedback outflows

    CERN Document Server

    Zubovas, Kastytis

    2014-01-01

    It is usually assumed that outflows from luminous AGN are either in the energy-conserving (non-radiative) or in the momentum-conserving (radiative) regime. We show that in a non-spherical geometry the effects of both regimes may manifest at the same time, and that it is the momentum of the outflow that sets the $M_{\\rm BH}-\\sigma$ relation. Considering an initially elliptical distribution of gas in the host galaxy, we show that a non-radiative outflow opens up a wide ``escape route'' over the paths of least resistance. Most of the outflow energy escapes in that direction. At the same time, in the directions of higher resistance, the ambient gas is affected mainly by the incident momentum from the outflow. Quenching SMBH growth requires quenching gas delivery along the paths of highest resistance, and therefore, it is the momentum of the outflow that limits the black hole growth. We present an analytical argument showing that such energy-conserving feedback bubbles driving leaky ambient shells will terminate S...

  10. The Prevalence of Ionized Gas Outflows in Type 2 AGNs II. 3-D Biconical Outflow Models

    CERN Document Server

    Bae, Hyun-Jin

    2016-01-01

    We present 3-D models of biconical outflows combined with a thin dust plane for investigating the physical properties of the ionized gas outflows and their effect on the observed gas kinematics in type 2 active galactic nuclei (AGNs). Using a set of input parameters, we construct a number of models in 3-D and calculate the spatially integrated velocity and velocity dispersion for each model. We find that three primary parameters, i.e., intrinsic velocity, bicone inclination, and the amount of dust extinction, mainly determine the simulated velocity and velocity dispersion. Velocity dispersion increases as the intrinsic velocity or the bicone inclination increases, while velocity (i.e., velocity shift with respect to systemic velocity) increases as the amount of dust extinction increases. Simulated emission-line profiles well reproduce the observed [O III] line profiles, e.g., a narrow core and a broad wing components. By comparing model grids and Monte Carlo simulations with the observed [O III] velocity-velo...

  11. RADIATION TRANSPORT FOR EXPLOSIVE OUTFLOWS: OPACITY REGROUPING

    International Nuclear Information System (INIS)

    Implicit Monte Carlo (IMC) and Discrete Diffusion Monte Carlo (DDMC) are methods used to stochastically solve the radiative transport and diffusion equations, respectively. These methods combine into a hybrid transport-diffusion method we refer to as IMC-DDMC. We explore a multigroup IMC-DDMC scheme that in DDMC, combines frequency groups with sufficient optical thickness. We term this procedure ''opacity regrouping''. Opacity regrouping has previously been applied to IMC-DDMC calculations for problems in which the dependence of the opacity on frequency is monotonic. We generalize opacity regrouping to non-contiguous groups and implement this in SuperNu, a code designed to do radiation transport in high-velocity outflows with non-monotonic opacities. We find that regrouping of non-contiguous opacity groups generally improves the speed of IMC-DDMC radiation transport. We present an asymptotic analysis that informs the nature of the Doppler shift in DDMC groups and summarize the derivation of the Gentile-Fleck factor for modified IMC-DDMC. We test SuperNu using numerical experiments including a quasi-manufactured analytic solution, a simple 10 group problem, and the W7 problem for Type Ia supernovae. We find that opacity regrouping is necessary to make our IMC-DDMC implementation feasible for the W7 problem and possibly Type Ia supernova simulations in general. We compare the bolometric light curves and spectra produced by the SuperNu and PHOENIX radiation transport codes for the W7 problem. The overall shape of the bolometric light curves are in good agreement, as are the spectra and their evolution with time. However, for the numerical specifications we considered, we find that the peak luminosity of the light curve calculated using SuperNu is ∼10% less than that calculated using PHOENIX

  12. RADIATION TRANSPORT FOR EXPLOSIVE OUTFLOWS: OPACITY REGROUPING

    Energy Technology Data Exchange (ETDEWEB)

    Wollaeger, Ryan T. [Department of Nuclear Engineering and Engineering Physics, University of Wisconsin, Madison 1500 Engineering Drive, 410 ERB, Madison, WI 53706 (United States); Van Rossum, Daniel R., E-mail: wollaeger@wisc.edu, E-mail: daan@flash.uchicago.edu [Flash Center for Computational Science, Department of Astronomy and Astrophysics, University of Chicago, Chicago, IL 60637 (United States)

    2014-10-01

    Implicit Monte Carlo (IMC) and Discrete Diffusion Monte Carlo (DDMC) are methods used to stochastically solve the radiative transport and diffusion equations, respectively. These methods combine into a hybrid transport-diffusion method we refer to as IMC-DDMC. We explore a multigroup IMC-DDMC scheme that in DDMC, combines frequency groups with sufficient optical thickness. We term this procedure ''opacity regrouping''. Opacity regrouping has previously been applied to IMC-DDMC calculations for problems in which the dependence of the opacity on frequency is monotonic. We generalize opacity regrouping to non-contiguous groups and implement this in SuperNu, a code designed to do radiation transport in high-velocity outflows with non-monotonic opacities. We find that regrouping of non-contiguous opacity groups generally improves the speed of IMC-DDMC radiation transport. We present an asymptotic analysis that informs the nature of the Doppler shift in DDMC groups and summarize the derivation of the Gentile-Fleck factor for modified IMC-DDMC. We test SuperNu using numerical experiments including a quasi-manufactured analytic solution, a simple 10 group problem, and the W7 problem for Type Ia supernovae. We find that opacity regrouping is necessary to make our IMC-DDMC implementation feasible for the W7 problem and possibly Type Ia supernova simulations in general. We compare the bolometric light curves and spectra produced by the SuperNu and PHOENIX radiation transport codes for the W7 problem. The overall shape of the bolometric light curves are in good agreement, as are the spectra and their evolution with time. However, for the numerical specifications we considered, we find that the peak luminosity of the light curve calculated using SuperNu is ∼10% less than that calculated using PHOENIX.

  13. Preoperative cardiac risk management

    OpenAIRE

    Vidaković Radosav; Poldermans Don; Nešković Aleksandar N.

    2011-01-01

    Approximately 100 million people undergo noncardiac surgery annually worldwide. It is estimated that around 3% of patients undergoing noncardiac surgery experience a major adverse cardiac event. Although cardiac events, like myocardial infarction, are major cause of perioperative morbidity or mortality, its true incidence is difficult to assess. The risk of perioperative cardiac complications depends mainly on two conditions: 1) identified risk factors, and 2) the type of the surgical p...

  14. Urinary Tract Infections (For Kids)

    Medline Plus

    Full Text Available ... your urinary tract, take these steps: Keep clean. Wash your private parts every day when you take ... choices. Those trips to the bathroom can help wash bacteria out of your body and cranberry juice ...

  15. Urinary Tract Infections in Children

    Directory of Open Access Journals (Sweden)

    Mustafa Taskesen

    2009-04-01

    Full Text Available Urinary tract infections (UTI are frequent conditions in children. Untreated urinary tract infections can lead to serious kidney problems that could threaten the life of the child. Therefore, early detection and treatment of urinary tract infection is important. In older children, urinary tract infections may cause obvious symptoms such as stomach ache and disuria. In infants and young children, UTIs may be harder to detect because of less specific symptoms. Recurrences are common in children with urinary abnormalities such as neurogenic bladder, vesicourethral reflux or those with very poor toilet and hygiene habits. This article reviews the diagnostic approach and presents the current data related to the roles of radiologic imaging, surgical correction and antibiotic prophylaxis of UTIs in children. [Archives Medical Review Journal 2009; 18(2.000: 57-69

  16. Urinary Tract Infections (For Kids)

    Medline Plus

    Full Text Available ... Urinary Tract Troubles Girls are more likely than boys to get a UTI. That's because their urethras are much shorter than boys' urethras. The shorter urethra means bacteria can get ...

  17. Stress gastric ulcer after cardiac surgery: Pathogenesis risk factors and medical management

    OpenAIRE

    Mahdi Ait Houssa; Noureddine Atmani; Fouad Nya; Abdessamad Abdou; Younes Moutakiallah; Mehdi Bamous; Mohamed Drissi; Abdelatif Boulahya

    2013-01-01

    Stress ulcer lesions of upper gastrointestinal tract are well recognized in patients undergoing open cardiac surgery. Gastrointestinal bleeding following cardiac surgery is infrequent with significant morbidity and mortality. The pathogenesis of mucosal lesions and subsequent haemorrhage is complex and multifactorial. The diagnosis as well as the treatment of this complication remains a challenge for surgeons. Identifying the source of bleeding can be difficult. Despite of the successful con...

  18. Colonic malakoplakia in a cardiac transplant recipient

    Directory of Open Access Journals (Sweden)

    Niamathullah Sadiya

    2014-08-01

    Full Text Available Malakoplakia is a rare inflammatory condition which is usually seen in the urogenital tract and less commonly in the gastrointestinal tract. Gastrointestinal malakoplakia may be associated with organ transplantation. There are previously only three reported cases of malakoplakia in cardiac transplant recipient. We report a case of colonic malakoplakia in a 38‑year‑old male who underwent cardiac transplantation for dilated cardiomyopathy 4 years previously and who had been on tacrolimus and mycophenolate. The patient presented with history of diarrhea associated with fecal incontinence for the past 6 months. Ileocolonoscopic examination was within normal limits. A rectal biopsy was done to exclude microscopic pathology. Microscopy revealed expansion of the lamina propria by histiocytes admixed with a few lymphocytes. The histiocytes showed granular eosinophilic cytoplasm with intracytoplasmic presence of Michaelis‑Gutmann bodies, rounded basophilic laminated structures having central core with a targetoid appearance. These stained positively for Von kossa stain for calcium and were diagnostic for malakoplakia. Although rare, malakoplakia may be associated with chronic diarrhea even if there are no macroscopic lesions seen during colonoscopy. The patient’s symptoms resolved with long‑term ciprofloxacin therapy

  19. Kiloparsec-scale outflows are prevalent among luminous AGN: outflows and feedback in the context of the overall AGN population

    CERN Document Server

    Harrison, C M; Mullaney, J R; Swinbank, A M

    2014-01-01

    We present integral field unit (IFU) observations covering the [O III]4959,5007 and H-Beta emission lines of sixteen z~(6-16) kpc in all targets and observe signatures of spherical outflows and bi-polar superbubbles. We show that our targets are representative of z 5x10^41 erg/s) type 2 AGN and that ionised outflows are not only common but also in >=70% (3 sigma confidence) of cases, they are extended over kiloparsec scales. Our study demonstrates that galaxy-wide energetic outflows are not confined to the most extreme star-forming galaxies or radio-luminous AGN; however, there may be a higher incidence of the most extreme outflow velocities in quasars hosted in ultra-luminous infrared galaxies. Both star formation and AGN activity appear to be energetically viable to drive the outflows and we find no definitive evidence that favours one process over the other. Although highly uncertain, we derive mass outflow rates (typically ~10x the SFRs), kinetic energies (~0.5-10% of L[AGN]) and momentum rates (typically...

  20. Management of Infection in the Post-Cardiac-Transplant Patient

    OpenAIRE

    Zeluff, Barry; Gentry, Layne O.

    1987-01-01

    In reviewing our post-transplant experience with infection in 192 cardiac transplant patients, * we have noticed a pattern. During the first month following transplantation, the patient seldom has an opportunistic infection, but is in danger of nosocomial infection (84 episodes in 57 patients). These include wound infection, and infections of the lungs, blood, and urinary tract. After the first month, and for the duration of the first year following transplantation, nosocomial infections beco...

  1. Catheter-Associated Urinary Tract Infections

    Science.gov (United States)

    ... Top of page What is a urinary tract infection? A urinary tract infection (UTI) is an infection that involves ... page What is a catheter-associated urinary tract infection (CAUTI)? A catheter-associated urinary tract infection (CAUTI) occurs when germs (usually bacteria) ...

  2. Modeling jet and outflow feedback during star cluster formation

    International Nuclear Information System (INIS)

    Powerful jets and outflows are launched from the protostellar disks around newborn stars. These outflows carry enough mass and momentum to transform the structure of their parent molecular cloud and to potentially control star formation itself. Despite their importance, we have not been able to fully quantify the impact of jets and outflows during the formation of a star cluster. The main problem lies in limited computing power. We would have to resolve the magnetic jet-launching mechanism close to the protostar and at the same time follow the evolution of a parsec-size cloud for a million years. Current computer power and codes fall orders of magnitude short of achieving this. In order to overcome this problem, we implement a subgrid-scale (SGS) model for launching jets and outflows, which demonstrably converges and reproduces the mass, linear and angular momentum transfer, and the speed of real jets, with ∼1000 times lower resolution than would be required without the SGS model. We apply the new SGS model to turbulent, magnetized star cluster formation and show that jets and outflows (1) eject about one-fourth of their parent molecular clump in high-speed jets, quickly reaching distances of more than a parsec, (2) reduce the star formation rate by about a factor of two, and (3) lead to the formation of ∼1.5 times as many stars compared to the no-outflow case. Most importantly, we find that jets and outflows reduce the average star mass by a factor of ∼ three and may thus be essential for understanding the characteristic mass of the stellar initial mass function.

  3. OUTFLOW AND HOT DUST EMISSION IN HIGH-REDSHIFT QUASARS

    International Nuclear Information System (INIS)

    Correlations of hot dust emission with outflow properties are investigated, based on a large z ∼ 2 non-broad absorption line quasar sample built from the Wide-field Infrared Survey and the Sloan Digital Sky Survey data releases. We use the near-infrared slope and the infrared to UV luminosity ratio to indicate the hot dust emission relative to the emission from the accretion disk. In our luminous quasars, these hot dust emission indicators are almost independent of the fundamental parameters, such as luminosity, Eddington ratio and black hole mass, but moderately dependent on the blueshift and asymmetry index (BAI) and FWHM of C IV lines. Interestingly, the latter two correlations dramatically strengthen with increasing Eddington ratio. We suggest that, in high Eddington ratio quasars, C IV regions are dominated by outflows so the BAI and FWHM (C IV) can reliably reflect the general properties and velocity of outflows, respectively. In low Eddington ratio quasars, on the other hand, C IV lines are primarily emitted by virialized gas so the BAI and FWHM (C IV) become less sensitive to outflows. Therefore, the correlations for the highest Eddington ratio quasars are more likely to represent the true dependence of hot dust emission on outflows and the correlations for the entire sample are significantly diluted by the low Eddington ratio quasars. Our results show that an outflow with a large BAI or velocity can double the hot dust emission on average. We suggest that outflows either contain hot dust in themselves or interact with the dusty interstellar medium or torus

  4. PROTOSTELLAR OUTFLOWS AND RADIATIVE FEEDBACK FROM MASSIVE STARS

    International Nuclear Information System (INIS)

    We carry out radiation hydrodynamical simulations of the formation of massive stars in the super-Eddington regime including both their radiative feedback and protostellar outflows. The calculations start from a prestellar core of dusty gas and continue until the star stops growing. The accretion ends when the remnants of the core are ejected, mostly by the force of the direct stellar radiation in the polar direction and elsewhere by the reradiated thermal infrared radiation. How long the accretion persists depends on whether the protostellar outflows are present. We set the mass outflow rate to 1% of the stellar sink particle's accretion rate. The outflows open a bipolar cavity extending to the core's outer edge, through which the thermal radiation readily escapes. The radiative flux is funneled into the polar directions while the core's collapse proceeds near the equator. The outflow thus extends the ''flashlight effect'', or anisotropic radiation field, found in previous studies from the few hundred AU scale of the circumstellar disk up to the 0.1 parsec scale of the core. The core's flashlight effect allows core gas to accrete on the disk for longer, in the same way that the disk's flashlight effect allows disk gas to accrete on the star for longer. Thus although the protostellar outflows remove material near the core's poles, causing slower stellar growth over the first few free-fall times, they also enable accretion to go on longer in our calculations. The outflows ultimately lead to stars of somewhat higher mass

  5. PROTOSTELLAR OUTFLOWS AND RADIATIVE FEEDBACK FROM MASSIVE STARS

    Energy Technology Data Exchange (ETDEWEB)

    Kuiper, Rolf [Max Planck Institute for Astronomy, Königstuhl 17, D-69117 Heidelberg (Germany); Yorke, Harold W.; Turner, Neal J., E-mail: kuiper@mpia.de, E-mail: Harold.W.Yorke@jpl.nasa.gov, E-mail: Neal.J.Turner@jpl.nasa.gov [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States)

    2015-02-20

    We carry out radiation hydrodynamical simulations of the formation of massive stars in the super-Eddington regime including both their radiative feedback and protostellar outflows. The calculations start from a prestellar core of dusty gas and continue until the star stops growing. The accretion ends when the remnants of the core are ejected, mostly by the force of the direct stellar radiation in the polar direction and elsewhere by the reradiated thermal infrared radiation. How long the accretion persists depends on whether the protostellar outflows are present. We set the mass outflow rate to 1% of the stellar sink particle's accretion rate. The outflows open a bipolar cavity extending to the core's outer edge, through which the thermal radiation readily escapes. The radiative flux is funneled into the polar directions while the core's collapse proceeds near the equator. The outflow thus extends the ''flashlight effect'', or anisotropic radiation field, found in previous studies from the few hundred AU scale of the circumstellar disk up to the 0.1 parsec scale of the core. The core's flashlight effect allows core gas to accrete on the disk for longer, in the same way that the disk's flashlight effect allows disk gas to accrete on the star for longer. Thus although the protostellar outflows remove material near the core's poles, causing slower stellar growth over the first few free-fall times, they also enable accretion to go on longer in our calculations. The outflows ultimately lead to stars of somewhat higher mass.

  6. Modeling jet and outflow feedback during star cluster formation

    Energy Technology Data Exchange (ETDEWEB)

    Federrath, Christoph [Monash Centre for Astrophysics, School of Mathematical Sciences, Monash University, VIC 3800 (Australia); Schrön, Martin [Department of Computational Hydrosystems, Helmholtz Centre for Environmental Research-UFZ, Permoserstr. 15, D-04318 Leipzig (Germany); Banerjee, Robi [Hamburger Sternwarte, Gojenbergsweg 112, D-21029 Hamburg (Germany); Klessen, Ralf S., E-mail: christoph.federrath@monash.edu [Universität Heidelberg, Zentrum für Astronomie, Institut für Theoretische Astrophysik, Albert-Ueberle-Strasse 2, D-69120 Heidelberg (Germany)

    2014-08-01

    Powerful jets and outflows are launched from the protostellar disks around newborn stars. These outflows carry enough mass and momentum to transform the structure of their parent molecular cloud and to potentially control star formation itself. Despite their importance, we have not been able to fully quantify the impact of jets and outflows during the formation of a star cluster. The main problem lies in limited computing power. We would have to resolve the magnetic jet-launching mechanism close to the protostar and at the same time follow the evolution of a parsec-size cloud for a million years. Current computer power and codes fall orders of magnitude short of achieving this. In order to overcome this problem, we implement a subgrid-scale (SGS) model for launching jets and outflows, which demonstrably converges and reproduces the mass, linear and angular momentum transfer, and the speed of real jets, with ∼1000 times lower resolution than would be required without the SGS model. We apply the new SGS model to turbulent, magnetized star cluster formation and show that jets and outflows (1) eject about one-fourth of their parent molecular clump in high-speed jets, quickly reaching distances of more than a parsec, (2) reduce the star formation rate by about a factor of two, and (3) lead to the formation of ∼1.5 times as many stars compared to the no-outflow case. Most importantly, we find that jets and outflows reduce the average star mass by a factor of ∼ three and may thus be essential for understanding the characteristic mass of the stellar initial mass function.

  7. SUPERNOVAE AND AGN DRIVEN GALACTIC OUTFLOWS

    International Nuclear Information System (INIS)

    signifies the crossover of AGN domination in outflow properties from starburst activity at lower masses. We find that stellar mass for massive galaxies scales as M *∝M 0.26h, and for low-mass galaxies, M *∝M 5/3h.

  8. Absorption-line measurements of AGN outflows

    Science.gov (United States)

    Fields, Dale L.

    Investigations into the elemental abundances in two nearby active galaxies, the narrow-line Seyfert 1 Markarian 1044 and the Seyfert 1 Markarian 279, are reported. Spectra from three space-based observatories HST, FUSE, and CHANDRA, are used to measure absorption lines in material outflowing from the nucleus. I make multi-wavelength comparisons to better convert the ionic column densities into elemental column densities which can then be used to determine abundances (metallicities). Narrow-line Seyfert 1 galaxies are known to have extreme values of a number of properties compared to active galactic nuclei (AGNs) as a class. In particular, emission-line studies have suggested that NLS1s are unusually metal-rich compared to broad-line AGNs of comparable luminosity. To test these suggestions I perform absorption-line studies on the NLS1 Markarian 1044, a nearby and bright AGN. I use lines of H I, C IV, N V, and O VI to properly make the photoionization correction through the software Cloudy and determine abundances of Carbon, Nitrogen and Oxygen. I find two results. The first is that Markarian 1044 has a bulk metallicity greater than five times solar. The second is that the N/C ratio in Markarian 1044 is consistent with a solar mixture. This is in direct contradiction of extrapolations from local H II regions which state N/ C should scale with bulk metallicity. This implies a different enrichment history in Markarian 1044 than in the Galactic disk. I also report discovery of three new low-redshift Lya forest lines with log N HI >= 12:77 in the spectrum of Markarian 1044. This number is consistent with the 2.6 expected Lya forest lines in the path length to Markarian 1044. I also investigate the CHANDRA X-ray spectrum of Markarian 279, a broad-line Seyfert 1. I use a new code, PHASE, to self-consistently model the entire absorption spectrum simultaneously. Using solely the X-ray spectrum I am able to determine the physical parameters of this absorber to a degree only

  9. Short-duration spaceflight impairs human carotid baroreceptor-cardiac reflex responses

    Science.gov (United States)

    Fritsch, Janice M.; Charles, John B.; Bennett, Barbara S.; Jones, Michele M.; Eckberg, Dwain L.

    1992-01-01

    The effect of a spaceflight on the vagally mediated baroreceptor-cardiac reflex responses of humans were investigated by measuring the responses (provoked by neck pressure changes) in supine position and the heart rate and blood pressure in the supine and standing positions in 16 astronauts before and after 4- to 5-day long Space Shuttle missions. The results showed that exposures to spaceflight resulted in reduced baseline levels of the vagal-cardiac outflow and the vagally mediated responses to changes of the arterial baroreceptor input and that these changes contribute to postflight reductions of astronauts' ability to maintain standing arterial pressures.

  10. Blunt cardiac rupture.

    Science.gov (United States)

    Martin, T D; Flynn, T C; Rowlands, B J; Ward, R E; Fischer, R P

    1984-04-01

    Blunt injury to the heart ranges from contusion to disruption. This report comprises 14 patients seen during a 6-year period with cardiac rupture secondary to blunt trauma. Eight patients were injured in automobile accidents, two patients were injured in auto-pedestrian accidents, two were kicked in the chest by ungulates, and two sustained falls. Cardiac tamponade was suspected in ten patients. Five patients presented with prehospital cardiac arrest or arrested shortly after arrival. All underwent emergency department thoracotomy without survival. Two patients expired in the operating room during attempted cardiac repair; both had significant extracardiac injury. Seven patients survived, three had right atrial injuries, three had right ventricular injuries, and one had a left atrial injury. Cardiopulmonary bypass was not required for repair of the surviving patients. There were no significant complications from the cardiac repair. The history of significant force dispersed over a relatively small area of the precordium as in a kicking injury from an animal or steering wheel impact should alert the physician to possible cardiac rupture. Cardiac rupture should be considered in patients who present with signs of cardiac tamponade or persistent thoracic bleeding after blunt trauma. PMID:6708151

  11. Immune Cells in the Female Reproductive Tract

    OpenAIRE

    Lee, Sung Ki; Kim, Chul Jung; Kim, Dong-Jae; Kang, Jee-Hyun

    2015-01-01

    The female reproductive tract has two main functions: protection against microbial challenge and maintenance of pregnancy to term. The upper reproductive tract comprises the fallopian tubes and the uterus, including the endocervix, and the lower tract consists of the ectocervix and the vagina. Immune cells residing in the reproductive tract play contradictory roles: they maintain immunity against vaginal pathogens in the lower tract and establish immune tolerance for sperm and an embryo/fetus...

  12. Bile Acid Analysis in Biliary Tract Cancer

    OpenAIRE

    Park, Jeong Youp; Park, Byung Kyu; Ko, Jun Sang; Bang, Seungmin; Song, Si Young; Chung, Jae Bock

    2006-01-01

    The etiology of biliary tract cancer is obscure, but there are evidences that bile acid plays a role in carcinogenesis. To find the association between biliary tract cancer and bile acid, this study compared the bile acid concentration and composition among patients with biliary cancer, biliary tract stones, and no biliary disease. Bile was compared among patients with biliary tract cancer (n = 26), biliary tract stones (n = 29), and disease free controls (n = 9). Samples were obtained by per...

  13. Biomaterials for cardiac regeneration

    CERN Document Server

    Ruel, Marc

    2015-01-01

    This book offers readers a comprehensive biomaterials-based approach to achieving clinically successful, functionally integrated vasculogenesis and myogenesis in the heart. Coverage is multidisciplinary, including the role of extracellular matrices in cardiac development, whole-heart tissue engineering, imaging the mechanisms and effects of biomaterial-based cardiac regeneration, and autologous bioengineered heart valves. Bringing current knowledge together into a single volume, this book provides a compendium to students and new researchers in the field and constitutes a platform to allow for future developments and collaborative approaches in biomaterials-based regenerative medicine, even beyond cardiac applications. This book also: Provides a valuable overview of the engineering of biomaterials for cardiac regeneration, including coverage of combined biomaterials and stem cells, as well as extracellular matrices Presents readers with multidisciplinary coverage of biomaterials for cardiac repair, including ...

  14. Mathematical cardiac electrophysiology

    CERN Document Server

    Colli Franzone, Piero; Scacchi, Simone

    2014-01-01

    This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematica...

  15. Cluster Formation in Protostellar Outflow-driven Turbulence

    Science.gov (United States)

    Li, Zhi-Yun; Nakamura, Fumitaka

    2006-04-01

    Most, perhaps all, stars go through a phase of vigorous outflow during formation. We examine, through three-dimensional MHD simulation, the effects of protostellar outflows on cluster formation. We find that the initial turbulence in the cluster-forming region is quickly replaced by motions generated by outflows. The protostellar outflow-driven turbulence (``protostellar turbulence'' for short) can keep the region close to a virial equilibrium long after the initial turbulence has decayed away. We argue that there exist two types of turbulence in star-forming clouds: a primordial (or ``interstellar'') turbulence and a protostellar turbulence, with the former transformed into the latter mostly in embedded clusters such as NGC 1333. Since the majority of stars are thought to form in clusters, an implication is that the stellar initial mass function is determined to a large extent by the stars themselves, through outflows that individually limit the mass accretion onto forming stars and collectively shape the environments (density structure and velocity field) in which most cluster members form. We speculate that massive cluster-forming clumps supported by protostellar turbulence gradually evolve toward a highly centrally condensed ``pivotal'' state, culminating in rapid formation of massive stars in the densest part through accretion.

  16. Quasar Outflow Constraints using Broad Absorption Line Variability Studies

    Science.gov (United States)

    McGraw, Sean; Shields, Joseph C.; Hamann, Fred; Capellupo, Daniel M.; Gallagher, Sarah; Brandt, W. Niel; Herbst, Hanna

    2016-01-01

    Quasar outflows are plausible candidates for AGN feedback processes influencing the host galaxy and may explain the established correlations between the supermassive black hole (SMBH) and the surrounding bulge. In order to better understand feedback and the physical conditions of the outflowing gas, observational constraints on absorber kinematics and energetics are needed. We are utilizing multiple epoch, rest frame UV quasar spectra to establish limits on outflow locations and total column densities for the purpose of estimating wind kinetic energies and momenta. We are also investigating the variability patterns of broad absorption lines (BALs) and mini-BALs across a range of ionization states to probe underlying connections between the various classes of absorbers. This work employs observations from the Sloan Digital Sky Survey, Hobby Eberly Telescope, and MDM observatory. We detect BAL variability in 3 out of 12 FeLoBAL quasars over multiple year timescales and conclude that the variable absorbers lie within tens of parsecs of the SMBH based on interpretations of the Fe II and Mg II BALS. We also measure significant BAL changes across daily to yearly timescales in a sample of 71 quasars with plausible detections of the P V 1117,1128 BAL. Detecting phosphorus in absorption is notable because it traces high column density outflows and is therefore relevant for studying AGN feedback. Constraints on outflow energetics and other selected results will be presented.

  17. Estimation of cold plasma outflow during geomagnetic storms

    Science.gov (United States)

    Haaland, S.; Eriksson, A.; André, M.; Maes, L.; Baddeley, L.; Barakat, A.; Chappell, R.; Eccles, V.; Johnsen, C.; Lybekk, B.; Li, K.; Pedersen, A.; Schunk, R.; Welling, D.

    2015-12-01

    Low-energy ions of ionospheric origin constitute a significant contributor to the magnetospheric plasma population. Measuring cold ions is difficult though. Observations have to be done at sufficiently high altitudes and typically in regions of space where spacecraft attain a positive charge due to solar illumination. Cold ions are therefore shielded from the satellite particle detectors. Furthermore, spacecraft can only cover key regions of ion outflow during segments of their orbit, so additional complications arise if continuous longtime observations, such as during a geomagnetic storm, are needed. In this paper we suggest a new approach, based on a combination of synoptic observations and a novel technique to estimate the flux and total outflow during the various phases of geomagnetic storms. Our results indicate large variations in both outflow rates and transport throughout the storm. Prior to the storm main phase, outflow rates are moderate, and the cold ions are mainly emanating from moderately sized polar cap regions. Throughout the main phase of the storm, outflow rates increase and the polar cap source regions expand. Furthermore, faster transport, resulting from enhanced convection, leads to a much larger supply of cold ions to the near-Earth region during geomagnetic storms.

  18. Star Formation Ecology: YSO Outflow Feedback in Young Clusters

    Science.gov (United States)

    Frank, Adam; Bally, John; Blackman, Eric; Gutermuth, Robert; Pipher, Judy; Quillen, Alice

    2007-05-01

    Energetic outflows associated with young stellar objects exert a strong effect on their parent molecular clouds. The dynamics of this interaction is yet to be well understood. In particular the role of jets and outflows in powering cloud turbulence, modifying the star formation efficiency (SFE) and/or disrupting the parent clouds remains unclear. Spitzer images of young clusters have provided new views of jet-cloud interactions that can help resolve these critical issues. In this proposal we seek to continue a highly successful (cycle 2) theory program to explore theoretical issues of jet-cloud interactions, turbulence and cloud disruption. Our research relies on 3-D Adaptive Mesh Refinement hydrodynamic and MHD simulations developed in house, in concert with Spitzer databases and other complementary observations. The team we have assembled includes computational and analytic theorists (Frank, Blackman) as well as observers who have worked closely with existing Spitzer Datasets (Bally, Quillen, Pipher, Gutermuth) The work funded through the previous TR program revealed fundamentally new aspects of YSO outflow feedback on parent cloud cores including the importance of the temporal evolution of outflow power. In this proposal we seek to extend the understanding gained in those studies to address specific questions on the nature and efficacy of outflow feedback in real systems.

  19. Evidence for outflows in z ~ 6 galaxies with ALMA

    CERN Document Server

    Gallerani, S; Feruglio, C; Ferrara, A; Maiolino, R; Vallini, L; Riechers, D A

    2016-01-01

    We present the first attempt to detect outflows from galaxies approaching the Epoch of Reionization (EoR) using a sample of 9 star-forming (5 < SFR < 70 Msun/yr) z ~ 6 galaxies for which high-quality spectra of the [CII]158 micron line has been previously obtained with ALMA. We first fit each line with a Gaussian function and compute the residuals by subtracting the best fitting model from the data. We combine the residuals of all sample galaxies and find that the total signal is characterized by a flux excess that can be ascribed to broad wings of the [CII] line, which we interpret as a signature of starburst-driven outflows. The tentatively inferred outflow rate is dM/dt ~ 65 Msun/yr. Our interpretation is consistent with results from zoomed hydro- simulations of Dahlia, a z ~ 7 galaxy (SFR ~ 100 Msun/yr) whose feedback-regulated star formation results in an outflow rate dM/dt ~ 30 Msun/yr. These results suggest that starburst-driven outflows are in place in the EoR. Deeper observations of the [CII] l...

  20. Functional cardiac MRI for assessment of aortic valve disease; Aortenklappenstenose im MRT mit Dynamik und 3D

    Energy Technology Data Exchange (ETDEWEB)

    Sagmeister, F.; Ritter, C.; Machann, W.; Koestler, H.; Hahn, D.; Beer, M. [Universitaetsklinikum Wuerzburg, Institut fuer Roentgendiagnostik, Wuerzburg (Germany); Herrmann, S.; Voelker, W.; Weidemann, F. [Universitaetsklinikum Wuerzburg, Medizinische Klinik I, Wuerzburg (Germany)

    2010-06-15

    Aortic valve disease shows a rising incidence with the increasing mean age of Western populations. The detection of hemodynamic parameters, which transcends the mere assessment of valve morphology, has an important future potential concerning classification of the severity of disease. MRI allows a non-invasive and a spatially flexible view of the aortic valve and the adjacent anatomic region, left ventricular outflow tract (LVOT) and ascending aorta. Moreover, the technique allows the determination of functional hemodynamic parameters, such as flow velocities and effective orifice areas. The new approach of a serial systolic planimetry velocity-encoded MRI sequence (VENC-MRI) facilitates the sizing of blood-filled cardiac structures with the registration of changes in magnitude during systole. Additionally, the subvalvular VENC-MRI measurements improve the clinically important exact determination of the LVOT area with respect to its specific eccentric configuration and its systolic deformity. (orig.) [German] Erworbene Erkrankungen der Aortenklappe wie die Aortenklappenstenose zeigen mit zunehmender Alterungstendenz unserer Gesellschaft eine ansteigende Inzidenz. Die Erfassung ueber die reine Klappenmorphologie hinausgehender haemodynamischer Parameter hat ein wichtiges zukuenftiges Potenzial zur Schweregradeinschaetzung. Die MRT erlaubt eine nichtinvasive und raeumlich flexible Darstellung der Aortenklappe sowie ihrer benachbarten anatomischen Strukturen (linksventrikulaerer Ausflusstrakt/LVOT, Aorta ascendens). Darueber hinaus ist eine Bestimmung funktioneller haemodynamischer Parameter wie Flussgeschwindigkeiten und effektiven Oeffnungsflaechen (EOeF) moeglich. Der neue Ansatz einer seriellen Planimetrie geschwindigkeitskodierter MRT-Sequenzen (Velocity-encoding- [VENC-]MRT) erlaubt die Groessenbestimmung flussdurchstroemter kardialer Strukturen und die Aufzeichnung ihrer dynamischen Groessenveraenderung waehrend der Systole. Zusaetzlich ermoeglicht die

  1. [Cardiac evaluation before non-cardiac surgery].

    Science.gov (United States)

    Menzenbach, Jan; Boehm, Olaf

    2016-07-01

    Before non-cardiac surgery, evaluation of cardiac function is no frequent part of surgical treatment. European societies of anesthesiology and cardiology published consensus-guidelines in 2014 to present a reasonable approach for preoperative evaluation. This paper intends to differentiate the composite of perioperative risk and to display the guidelines methodical approach to handle it. Features to identify patients at risk from an ageing population with comorbidities, are the classification of surgical risk, functional capacity and risk indices. Application of diagnostic means, should be used adjusted to this risk estimation. Cardiac biomarkers are useful to discover risk of complications or mortality, that cannot be assessed by clinical signs. After preoperative optimization and perioperative cardiac protection, the observation of the postoperative period remains, to prohibit complications or even death. In consideration of limited resources of intensive care department, postoperative ward rounds beyond intensive care units are considered to be an appropriate instrument to avoid or recognize complications early to reduce postoperative mortality. PMID:27479258

  2. Discs, outflows, and feedback in collapsing magnetized cores

    CERN Document Server

    Duffin, Dennis

    2010-01-01

    The pre-stellar cores in which low mass stars form are generally well magnetized. Our simulations show that early protostellar discs are massive and experience strong magnetic torques in the form of magnetic braking and protostellar outflows. Simulations of protostellar disk formation suggest that these torques are strong enough to suppress a rotationally supported structure from forming for near critical values of mass-to-flux. We demonstrate through the use of a 3D adaptive mesh refinement code -- including cooling, sink particles and magnetic fields -- that one produces transient 1000 AU discs while simultaneously generating large outflows which leave the core region, carrying away mass and angular momentum. Early inflow/outflow rates suggest that only a small fraction of the mass is lost in the initial magnetic tower/jet event.

  3. The outflow speed of the coma of Halley's comet

    International Nuclear Information System (INIS)

    Data concerning the outflow speed of the coma of Comet Halley are studied in relation to a generalization of the coupled pure-gas-dynamic/Monte Carlo model of Combi and Smyth (1988) to include the dusty-gas dynamics of the inner coma. Measurements made by the Giotto neutral-gas spectrometer, IR water observations from the Kuiper Airborne Observatory, and Doppler radio line profiles of HCN and OH are used to examine the radial dependence of the outflow speed, the asymmetry in the outflow speed, and the overall heliocentric distance dependence of the Doppler profiles, respectively. The results suggest that the model makes it possible to understand the gross long-term behavior and radial structure of the dynamics of the cometary coma. 23 refs

  4. Bipolar Molecular Outflows from High-Mass Protostars

    Science.gov (United States)

    Su, Yu-Nung; Zhang, Qizhou; Lim, Jeremy

    2004-03-01

    We report observations of the bipolar molecular outflows associated with the luminous (~2×104 Lsolar) far-IR sources IRAS 21519+5613 and IRAS 22506+5944, as well the dust and molecular gas condensations on which these outflows appear to be centered. The observations were made in 12CO, 13CO, C18O, and continuum at 3 mm with the BIMA array and in 12CO and 13CO with the NRAO 12 m telescope to recover extended emission filtered out by the interferometric array. We find that the outflow associated with each IRAS source shows a clear bipolar morphology in 12CO, with properties (i.e., total mass of order 10-100 Msolar, mass-outflow rate >~10-3 Msolar, dynamical timescale 104-105 yr, and energetics) comparable with those of other massive outflows associated with luminous young stellar objects. Each outflow appears to be centered on a dust and gas condensation with a mass of 200-300 Msolar, likely marking the location of the driving source. The outflow lobes of both sources are fully resolved along their major but not minor axes, and they have collimation factors that may be comparable with young low-mass stars. The mass-velocity diagrams of both outflows change in slope at a velocity of ~10 km s-1, suggesting that the high-velocity component (HVC) may drive the low-velocity component (LVC). Although the HVC of IRAS 21519+5613 shows evidence for deceleration, no such signature is seen in the HVC of IRAS 22506+5944. Neither HVC has a momentum supply rate sufficient to drive their corresponding LVCs, although it is possible that the HVC is more highly excited and hence its thrust underestimated. Like for other molecular outflows the primary driving agent cannot be ionized gas, leaving atomic gas as the other remaining candidate. Neither IRAS 21519+5613 nor IRAS 22506+5944 exhibits detectable free-free emission, which together with the observed properties of their molecular outflows and surrounding condensations make them credible candidates for high-mass protostars. The mass

  5. Plasma Outflows: Known Knowns, Known Unknowns, and The Unknown

    Science.gov (United States)

    Moore, T. E.

    2012-01-01

    A brief summary is given of i) what we know from observing ionospheric outflows and ii) how outflow parameterizations are being used in global simulations to evaluate their effects on magnetospheric dynamics. Then, a list of unanswered questions and issues to be resolved is given, followed by a description of the known future mission plans expressed in the Heliophysics Roadmap, such as Origin of Near-Earth Plasmas (ONEP), and Ion-Neutral Coupling in the Atmosphere (INCA). Finally, a set of requirements for definitive plasma outflow observations are identified, along with possible methods for fulfilling them in future missions. Since results of the current Heliophysics Decadal Survey are expected soon, it is hoped that future plans can be summarized and discussed without speculation at the GEM 2012 meeting.

  6. Outflow distribution at the distal anastomosis of infrainguinal bypass grafts.

    Science.gov (United States)

    Fisher, R K; How, T V; Bakran, A; Brennan, J A; Harris, P L

    2004-03-01

    Outflow distribution at the distal anastomosis of infrainguinal bypass grafts remains unquantified in vivo, but is likely to influence flow patterns and haemodynamics, thereby impacting upon graft patency. This study measured the ratio of distal to proximal outflow in 30 patients undergoing infrainguinal bypass for lower limb ischaemia, using a flow probe and a transit-time ultrasonic flow meter. The mean outflow distribution was approximately 75% distal to 25% proximal, with above knee anastomoses having a greater proportion of distal flow (84%) compared to below knee grafts (73%). These in vivo flow characteristics differ significantly from those used in theoretical models studying flow phenomena (50:50 and/or 100:0), and should be incorporated into future research. PMID:14757463

  7. Starburst Galaxies: Outflows of Metals and Energy into the IGM

    CERN Document Server

    Strickland, David K; Ptak, Andrew; Schlegel, Eric; Tremonti, Christy; Tsuru, Takeshi; Tuellmann, Ralph; Zezas, Andreas

    2009-01-01

    What is the contribution of mass, metals and energy from starburst galaxies to the Intergalactic Medium? Starburst galaxies drive galactic-scale outflows or "superwinds" that may be responsible for removing metals from galaxies and polluting the Intergalactic Medium (IGM). In the last decade tremendous progress was made in mapping cool entrained gas in superwinds through UV/optical imaging and absorption line spectroscopy. These studies demonstrated that superwinds are ubiquitous in galaxies forming stars at high surface densities and that the most powerful starbursts can drive outflows near escape velocity. Theoretical models of galaxy evolution have begun to incorporate superwinds, using various ad-hoc prescriptions based on our knowledge of the cool gas. However, these efforts are fundamentally impeded by our lack of information about the hot phase of these outflows. The hot X-ray emitting phase of a superwind contains the majority of its energy and newly-synthesized metals, and given its high specific ene...

  8. Studying the Outflow-Core Interaction with ALMA Cycle 1 Observations of the HH 46/47 Molecular Outflow

    CERN Document Server

    Zhang, Yichen; Mardones, Diego; Cabrit, Sylvie; Dunham, Michael M; Garay, Guido; Noriega-Crespo, Alberto; Offner, Stella S R; Raga, Alejandro C; Corder, Stuartt A

    2016-01-01

    We present ALMA Cycle 1 observations of the HH 46/47 molecular outflow using combined 12m array and 7m array observations. We use 13CO and C18O emission to correct for the 12CO optical depth, to accurately estimate the outflow mass, momentum and kinetic energy. Applying the optical depth correction increases the mass estimate by a factor of 14, the momentum by a factor of 6, and the kinetic energy by a factor of about 2. The new 13CO(1-0) and C18O(1-0) data also allow us to trace denser and slower outflow material than that traced by 12CO. These species are only detected within about 1~2 km/s from the cloud velocity. The cavity wall of the red lobe appears at very low velocities (~0.2 km/s). Combing the material traced only by 13CO and C18O, the measured total mass of the CO outflow is 1.4 Msun, the total momentum is 1.7 Msun km/s and the total energy is 4.7e43 erg, assuming Tex=15 K. The improved angular resolution and sensitivity in 12CO reveal more details of the outflow structure. Specifically, we find th...

  9. SiO: Not the perfect outflow tracer: Outflow studies of the massive star formation region IRAS 19410+2336

    CERN Document Server

    Widmann, Felix; Schilke, Peter; Stanke, Thomas

    2016-01-01

    Aims: Previous observations of the young massive star formation region IRAS 19410+2336 have revealed strong outflow activity with several interacting outflows. We aim to get a better understanding of the outflow activity in this region by observing the SiO and H$^{13}$CO$^+$ emission with high angular resolution. SiO is known to trace shocked gas, which is often associated with young energetic outflows. With the H$^{13}$CO$^+$ data, we intend to better understand the distribution of the quiescent gaseous component of the region. Methods: The SiO observations in the J=2-1 v=0 transition and H$^{13}$CO$^+$ J=1-0 observations were performed by the Plateau de Bure Interferometer, combined with IRAM 30 m single-dish observations, in order to get the missing short-spacing information. We complement this new high-resolution observation with earlier CO and H$_2$ data. Results: The SiO observations do not trace the previously in CO and H$_2$ identified outflows well. Although we identify regions of highly increased Si...

  10. Respiratory tract infection during Hajj

    Directory of Open Access Journals (Sweden)

    Alzeer Abdulaziz

    2009-01-01

    Full Text Available Respiratory tract infection during Hajj (pilgrimage to Mecca is a common illness, and it is responsible for most of the hospital admissions. Influenza virus is the leading cause of upper respiratory tract infection during Hajj, and pneumonia can be serious. Taking into account the close contacts among the pilgrims, as well as the crowding, the potential for transmission of M. tuberculosis is expected to be high. These pilgrims can be a source for spreading infection on their return home. Although vaccination program for influenza is implemented, its efficacy is uncertain in this religious season. Future studies should concentrate on prevention and mitigation of these infections.

  11. On the thermal line emission from the outflows in ultraluminous X-ray sources

    OpenAIRE

    Xu, Ya-Di; Cao, Xinwu

    2016-01-01

    The atomic features in the X-ray spectra of the ultraluminous X-ray source (ULX) may be associated with the outflow (Middleton et al. 2015), which may provide a way to explore the physics of the ULXs. We construct a conical outflow model, and calculate the thermal X-ray Fe emission lines from the outflows. Our results show that thermal line luminosity decreases with increasing outflow velocity or/and opening angle of the outflow for a fixed kinetic power of the outflows. Assuming the kinetic ...

  12. Can dark energy explain the observed outflow in galaxy clusters?

    CERN Document Server

    Donnari, M; Merafina, M

    2016-01-01

    Recent observations of the Virgo cluster and the Local Group suggested that some galaxies are flowing out from their parent cluster. This may be the signature that dark energy (DE) acts significantly also on small cosmological scales. By means of direct N-body simulations we performed several simulations, in which the effect of DE and gravity are taken into account, aiming to determine whether DE can produce an outflow of galaxies compatible with observations. Comparing the different simulations, our results suggest that the observed outflow of galaxies is likely due to the local effect of DE.

  13. Heating of the Intracluster Medium by Quasar Outflows

    Indian Academy of Sciences (India)

    Suparna Roychowdhury; Biman B. Nath

    2002-03-01

    We study the possibility of quasar outflows in clusters and groups of galaxies heating the intracluster gas in order to explain the recent observation of excess entropy in this gas. We show that radio galaxies alone cannot provide the energy required to explain the observations but the inclusion of Broad Absorption Line (BAL) outflows can do so, and that in this scenario most of the heating takes place at ∼ 1–4, the ``preheating” epoch being at a lower redshift for lower mass clusters.

  14. High Velocity Outflows in Narrow Absorption Line Quasars

    OpenAIRE

    Chartas, G.; Charlton, J.; Eracleous, M.; Giustini, M; Hidalgo, P. Rodriguez; R Ganguly; Hamann, F.; Misawa, T.; Tytler, D.

    2009-01-01

    The current paradigm for the AGN phenomenon is a central engine that consists of an inflow of material accreting in the form of a disk onto a supermassive black hole. Observations in the UV and optical find high velocity ionized material outflowing from the black hole. We present results from Suzaku and XMM-Newton observations of a sample of intrinsic NAL quasars with high velocity outflows. Our derived values of the intrinsic column densities of the X-ray absorbers are consistent with an out...

  15. The effects of vertical outflows on disk dynamos

    OpenAIRE

    Bardou, A.; Rekowski, B. v.; Dobler, W.; Brandenburg, A.; Shukurov, A.

    2000-01-01

    We consider the effect of vertical outflows on the mean-field dynamo in a thin disk. These outflows could be due to winds or magnetic buoyancy. We analyse both two-dimensional finite-difference numerical solutions of the axisymmetric dynamo equations and a free-decay mode expansion using the thin-disk approximation. Contrary to expectations, a vertical velocity can enhance dynamo action, provided it is not too strong. In the nonlinear regime this can lead to super-exponential growth of the ma...

  16. XMM observations of BAL Quasars with polar outflows

    OpenAIRE

    Wang, JunXian; Jiang, Peng; Zhou, Hongyan; Wang, Tinggui; Dong, Xiaobo; Wang, Huiyuan

    2008-01-01

    We have selected a sample of broad absorption line (BAL) quasars which show significant radio variations, indicating the presence of polar BAL outflows. We obtained snapshot XMM observations of four polar BAL QSOs, to check whether strong X-ray absorption, one of the most prominent characteristics of most BAL QSOs, also exist in polar outflows. Two of the sources are detected in X-ray. Spectral fittings show that they are X-ray normal with no intrinsic X-ray absorption, suggesting the X-ray s...

  17. The role of cosmic ray pressure in accelerating galactic outflows

    OpenAIRE

    Simpson, Christine M.; Pakmor, Ruediger; Marinacci, Federico; Pfrommer, Christoph; Springel, Volker; Glover, Simon C. O.; Clark, Paul C.; Smith, Rowan J.

    2016-01-01

    We study the formation of galactic outflows from supernova explosions (SNe) with the moving-mesh code AREPO in a stratified column of gas with a surface density similar to the Milky Way disk at the solar circle. We compare different simulation models for SNe placement and energy feedback, including cosmic rays (CR), and find that models that place SNe in dense gas and account for CR diffusion are able to drive outflows with similar mass loading as obtained from a random placement of SNe with ...

  18. River Outflow of the Conterminous United States, 1939-1988.

    Science.gov (United States)

    Guetter, Alexandre K.; Georgakakos, Konstantine P.

    1993-10-01

    A record of 50 years of daily outflows through the boundaries of the continental United States has been assembled based on observations recorded by U.S. Geological Survey streamflow stations. Only stations with continuous records from 1939 through 1988 were included. These stations (197 total) are near the outlets of rivers located at the vicinity of the Canadian, Mexican, Atlantic (including the Gulf of Mexico), and Pacific borders of the continental United States. The drainage area of the selected stations covers 77% of the conterminous United States, whereas the existing network of gauging stations covers 83% of the conterminous U.S. area. Station daily data were aggregated over the entire boundary of the United States and were integrated in monthly and annual totals. The 50-year average annual streamflow divergence normalized by the aggregated drainage area is 210.2 mm yr1, reaching a peak in April with 27.3 mm month1 and a minimum in September with 8.7 mm month1. The Mississippi-Missouri Basin comprises 50% of the gauged area and dominates the absolute value of the outflow discharge. Spectral analysis of the monthly outflow anomalies shows an 11-year dominant cycle. The 1939-1988 period contains four notable droughts. Two droughts are partially registered in the limits of the records characterized by the negative anomalies extending from 1939 to 1941 and by the 1987-1988 anomalies for the late 1980s drought. The middle 1950s and early 1960s droughts are fully included in the dataset. Periods of high outflows were registered in the middle 1940s, early 1970s, and early 1980s. Analysis of the spatial coherence of the annual anomalies shows large-scale features, whereas analysis of the monthly anomalies yields the frequency and persistence patterns of floods and droughts. An estimate of the climatological land-surface water budget for the continental United States was done based on recorded precipitation, panevaporation, and outflow. Eigenvector analysis of the

  19. Cardiac metabolism and arrhythmias

    OpenAIRE

    Barth, Andreas S.; Tomaselli, Gordon F.

    2009-01-01

    Sudden cardiac death remains a leading cause of mortality in the Western world, accounting for up to 20% of all deaths in the U.S.1, 2 The major causes of sudden cardiac death in adults age 35 and older are coronary artery disease (70–80%) and dilated cardiomyopathy (10–15%).3 At the molecular level, a wide variety of mechanisms contribute to arrhythmias that cause sudden cardiac death, ranging from genetic predisposition (rare mutations and common polymorphisms in ion channels and structural...

  20. [Cardiac Rehabilitation 2015].

    Science.gov (United States)

    Hoffmann, Andreas

    2015-11-25

    The goals of cardiac rehabilitation are (re-)conditioning and secondary prevention in patients with heart disease or an elevated cardiovascular risk profile. Rehabilitation is based on motivation through education, on adapted physical activity, instruction of relaxation techniques, psychological support and optimized medication. It is performed preferably in groups either in outpatient or inpatient settings. The Swiss working group on cardiac rehabilitation provides a network of institutions with regular quality auditing. Positive effects of rehabilitation programs on mortality and morbidity have been established by numerous studies. Although a majority of patients after cardiac surgery are being referred to rehabilitation, these services are notoriously underused after catheter procedures. PMID:26602848

  1. Comprehensive cardiac rehabilitation

    DEFF Research Database (Denmark)

    Kruse, Marie; Hochstrasser, Stefan; Zwisler, Ann-Dorthe O;

    2006-01-01

    OBJECTIVES: The costs of comprehensive cardiac rehabilitation are established and compared to the corresponding costs of usual care. The effect on health-related quality of life is analyzed. METHODS: An unprecedented and very detailed cost assessment was carried out, as no guidelines existed for...... uncertain and may be as high as euro 1.877. CONCLUSIONS: Comprehensive cardiac rehabilitation is more costly than usual care, and the higher costs are not outweighed by a quality of life gain. Comprehensive cardiac rehabilitation is, therefore, not cost-effective....

  2. (abstract) A Test of the Theoretical Models of Bipolar Outflows: The Bipolar Outflow in Mon R2

    Science.gov (United States)

    Xie, Taoling; Goldsmith, Paul; Patel, Nimesh

    1993-01-01

    We report some results of a study of the massive bipolar outflow in the central region of the relatively nearby giant molecular cloud Monoceros R2. We make a quantative comparison of our results with the Shu et al. outflow model which incorporates a radially directed wind sweeping up the ambient material into a shell. We find that this simple model naturally explains the shape of this thin shell. Although Shu's model in its simplest form predicts with reasonable parameters too much mass at very small polar angles, as previously pointed out by Masson and Chernin, it provides a reasonable good fit to the mass distribution at larger polar angles. It is possible that this discrepancy is due to inhomogeneities of the ambient molecular gas which is not considered by the model. We also discuss the constraints imposed by these results on recent jet-driven outflow models.

  3. Molecular Basis of Cardiac Myxomas

    Directory of Open Access Journals (Sweden)

    Pooja Singhal

    2014-01-01

    Full Text Available Cardiac tumors are rare, and of these, primary cardiac tumors are even rarer. Metastatic cardiac tumors are about 100 times more common than the primary tumors. About 90% of primary cardiac tumors are benign, and of these the most common are cardiac myxomas. Approximately 12% of primary cardiac tumors are completely asymptomatic while others present with one or more signs and symptoms of the classical triad of hemodynamic changes due to intracardiac obstruction, embolism and nonspecific constitutional symptoms. Echocardiography is highly sensitive and specific in detecting cardiac tumors. Other helpful investigations are chest X-rays, magnetic resonance imaging and computerized tomography scan. Surgical excision is the treatment of choice for primary cardiac tumors and is usually associated with a good prognosis. This review article will focus on the general features of benign cardiac tumors with an emphasis on cardiac myxomas and their molecular basis.

  4. Automatic Implantable Cardiac Defibrillator

    Medline Plus

    Full Text Available Automatic Implantable Cardiac Defibrillator February 19, 2009 Halifax Health Medical Center, Daytona Beach, FL Welcome to Halifax Health Daytona Beach, Florida. Over the next hour you' ...

  5. Sudden Cardiac Arrest

    Science.gov (United States)

    ... scan, or MUGA, which shows how well your heart is pumping blood. Magnetic resonance imaging (MRI) which gives doctors detailed pictures of your heart. How is SCA treated? Sudden cardiac arrest should ...

  6. Sudden Cardiac Arrest

    Science.gov (United States)

    ... Heart Risk Factors & Prevention Heart Diseases & Disorders Atrial Fibrillation (AFib) Sudden Cardiac Arrest (SCA) SCA: Who's At Risk? Prevention of SCA What Causes SCA? SCA Awareness Atrial Flutter Heart Block Heart Failure Sick Sinus Syndrome Substances & Heart Rhythm Disorders Symptoms & ...

  7. Sudden cardiac death

    Directory of Open Access Journals (Sweden)

    Aranđelović Aleksandra Č.

    2004-01-01

    Full Text Available Sudden cardiac death in an athlete is rare and tragic event. An athlete's death draws high public attention given that athletes are considered the healthiest category of society. The vast majority of sudden cardiac death in young athletes is due to congenital cardiac malformations such as hypertrophie cardiomyopathy and various coronary artery anomalies. In athletes over age 35, the usual cause of sudden cardiac death is coronary artery disease. With each tragic death of a young athlete, there is a question why this tragedy has not been prevented. The American College of Sports Medicine and the American Heart Association recommend that a pre-participation exam should include a complete cardiovascular history and physical examination.

  8. Cardiac Risk Assessment

    Science.gov (United States)

    ... to assess cardiac risk include: High-sensitivity C-reactive protein (hs-CRP) : Studies have shown that measuring ... LDL-C but does not respond to typical strategies to lower LDL-C such as diet, exercise, ...

  9. Eukyaryota in human digestive tract

    Czech Academy of Sciences Publication Activity Database

    Valtrová, T.; Mrázek, Jakub; Fliegerová, Kateřina

    Smolenice: IAP, Slovak Academy of Sciences, Košice, 2011. s. 80-80. ISBN 978-80-968618-6-6. [7th International Symposium on Anaerobic Microbiology. 15.6.2011-18.6.2011, Smolenice] Institutional research plan: CEZ:AV0Z50450515 Keywords : eukaryota * human digestive tract Subject RIV: EE - Microbiology, Virology

  10. Imaging of the Urinary Tract

    Science.gov (United States)

    ... takes pictures of the body’s internal organs and soft tissues without using x rays. MRI machines use radio waves and magnets to ... Urinary tract imaging techniques include conventional radiology, or x rays; ... tomography (CT) scans; and radionuclide scans. Preparations for an ...

  11. Urinary Tract Infections (For Kids)

    Medline Plus

    Full Text Available ... Your pee smells bad. These changes occur because bacteria have caused an infection somewhere in your urinary tract. Let's ... near your body, especially when it's hot outside. Bacteria love to grow in warm, moist places. Gross! Reviewed by: T. Ernesto Figueroa, ... Diseases Movie: Urinary System Your Urinary System Bedwetting Contact ...

  12. Gas in the Digestive Tract

    Science.gov (United States)

    ... a diary of your diet and gas symptoms. ​​​​ ​Treatment for Gas in the Digestive Tract To reduce or prevent gas and gas symptoms, your doctor may suggest that you reduce swallowed air, quit smoking, make changes to your diet, or take medicines. ...

  13. Biofilm infections of urinary tract

    Czech Academy of Sciences Publication Activity Database

    Holá, V.; Růžička, F.; Horáková, L.; Renata, R.; Horká, Marie

    Istanbul, 2008. s. 232. [International Congress of Bacteriology and Applied Microbiology /12./. 05.08.2008-09.08.2008, Istanbul] R&D Projects: GA AV ČR IAAX00310701 Keywords : catheter related urinary tract infections * affection of culture conditions * capillary isoelectric focusing Subject RIV: CB - Analytical Chemistry, Separation

  14. Cardiac arrest - cardiopulmonary resuscitation

    Institute of Scientific and Technical Information of China (English)

    Basri Lenjani; Besnik Elshani; Nehat Baftiu; Kelmend Pallaska; Kadir Hyseni; Njazi Gashi; Nexhbedin Karemani; Ilaz Bunjaku; Taxhidin Zaimi; Arianit Jakupi

    2014-01-01

    Objective:To investigate application of cardiopulmonary resuscitation(CPR) measures within the golden minutes inEurope.Methods:The material was taken from theUniversityClinical Center ofKosovo -EmergencyCentre inPristina, during the two(2) year period(2010-2011).The collected date belong to the patients with cardiac arrest have been recorded in the patients' log book protocol at the emergency clinic.Results:During the2010 to2011 in the emergency center of theCUCK inPristina have been treated a total of269 patients with cardiac arrest, of whom159 or59.1% have been treated in2010, and110 patients or40.9% in2011.Of the269 patients treated in the emergency centre,93 or34.6% have exited lethally in the emergency centre, and176 or 65.4% have been transferred to other clinics.In the total number of patients with cardiac arrest, males have dominated with186 cases, or69.1%.The average age of patients included in the survey was56.7 year oldSD±16.0 years.Of the269 patients with cardiac arrest, defibrillation has been applied for93 or34.6% of patients.In the outpatient settings defibrillation has been applied for3 or3.2% of patients.Patients were defibrillated with application of one to four shocks. Of27 cases with who have survived cardiac arrest, none of them have suffered cardiac arrest at home,3 or11.1% of them have suffered cardiac arrest on the street, and24 or88.9% of them have suffered cardiac arrest in the hospital.5 out of27 patients survived have ended with neurological impairment.Cardiac arrest cases were present during all days of the week, but frequently most reported cases have been onMonday with32.0% of cases, and onFriday with24.5% of cases. Conclusions:All survivors from cardiac arrest have received appropriate medical assistance within10 min from attack, which implies that if cardiac arrest occurs near an institution health care(with an opportunity to provide the emergent health care) the rate of survival is higher.

  15. Awareness in cardiac anesthesia.

    LENUS (Irish Health Repository)

    Serfontein, Leon

    2010-02-01

    Cardiac surgery represents a sub-group of patients at significantly increased risk of intraoperative awareness. Relatively few recent publications have targeted the topic of awareness in this group. The aim of this review is to identify areas of awareness research that may equally be extrapolated to cardiac anesthesia in the attempt to increase understanding of the nature and significance of this scenario and how to reduce it.

  16. Safety in cardiac surgery

    OpenAIRE

    Siregar, S.

    2013-01-01

    The monitoring of safety in cardiac surgery is a complex process, which involves many clinical, practical, methodological and statistical issues. The objective of this thesis was to measure and to compare safety in cardiac surgery in The Netherlands using the Netherlands Association for Cardio-Thoracic Surgery (NVT) database. The safety of care is usually measured using patient outcomes. If outcomes are not available, the process and structure of care may be used. Outcomes should be adjusted ...

  17. Cardiac rehabilitation in Germany.

    Science.gov (United States)

    Karoff, Marthin; Held, Klaus; Bjarnason-Wehrens, Birna

    2007-02-01

    The purpose of this review is to give an overview of the rehabilitation measures provided for cardiac patients in Germany and to outline its legal basis and outcomes. In Germany the cardiac rehabilitation system is different from rehabilitation measures in other European countries. Cardiac rehabilitation in Germany since 1885 is based on specific laws and the regulations of insurance providers. Cardiac rehabilitation has predominantly been offered as an inpatient service, but has recently been complemented by outpatient services. A general agreement on the different indications for offering these two services has yet to be reached. Cardiac rehabilitation is mainly offered after an acute cardiac event and bypass surgery. It is also indicated in severe heart failure and special cases of percutaneous coronary intervention. Most patients are men (>65%) and the age at which events occur is increasing. The benefits obtained during the 3-4 weeks after an acute event, and confirmed in numerous studies, are often later lost under 'usual care' conditions. Many attempts have been made by rehabilitation institutions to improve this deficit by providing intensive aftercare. One instrument set up to achieve this is the nationwide institution currently comprising more than 6000 heart groups with approximately 120000 outpatients. After coronary artery bypass grafting or acute coronary syndrome cardiac rehabilitation can usually be started within 10 days. The multidisciplinary rehabilitation team consists of cardiologists, psychologists, exercise therapists, social workers, nutritionists and nurses. The positive effects of cardiac rehabilitation are also important economically, for example, for the improvement of secondary prevention and vocational integration. PMID:17301623

  18. Ranolazine in Cardiac Arrhythmia.

    Science.gov (United States)

    Saad, Marwan; Mahmoud, Ahmed; Elgendy, Islam Y; Richard Conti, C

    2016-03-01

    Ranolazine utilization in the management of refractory angina has been established by multiple randomized clinical studies. However, there is growing evidence showing an evolving role in the field of cardiac arrhythmias. Multiple experimental and clinical studies have evaluated the role of ranolazine in prevention and management of atrial fibrillation, with ongoing studies on its role in ventricular arrhythmias. In this review, we will discuss the pharmacological, experimental, and clinical evidence behind ranolazine use in the management of various cardiac arrhythmias. PMID:26459200

  19. Cardiac tumours in infancy

    OpenAIRE

    Yadava, O.P.

    2012-01-01

    Cardiac tumours in infancy are rare and are mostly benign with rhabdomyomas, fibromas and teratomas accounting for the majority. The presentation depends on size and location of the mass as they tend to cause cavity obstruction or arrhythmias. Most rhabdomyomas tend to regress spontaneously but fibromas and teratomas generally require surgical intervention for severe haemodynamic or arrhythmic complications. Other relatively rare cardiac tumours too are discussed along with an Indian perspect...

  20. Cardiac Image Registration

    Directory of Open Access Journals (Sweden)

    2008-09-01

    Full Text Available Long procedure time and somewhat suboptimal results hinder the widespread use of catheter ablation of complex arrhythmias such as atrial fibrillation (AF. Due to lack of contrast differentiation between the area of interest and surrounding structures in a moving organ like heart, there is a lack of proper intraprocedural guidance using current imaging techniques for ablation. Cardiac image registration is currently under investigation and is in clinical use for AF ablation. Cardiac image registration, which involves integration of two images in the context of left atrium (LA, is intermodal, with the acquired image and the real-time reference image residing in different image spaces, and involves optimization, where one image space is transformed into the other. Unlike rigid body registration, cardiac image registration is unique and challenging due to cardiac motion during the cardiac cycle and due to respiration. This review addresses the basic principles of the emerging technique of registration and the inherent limitations as they relate to cardiac imaging and registration.

  1. Cardiac Image Registration

    Directory of Open Access Journals (Sweden)

    Jasbir Sra

    2008-09-01

    Full Text Available Long procedure time and somewhat suboptimal results hinder the widespread use of catheter ablation of complex arrhythmias such as atrial fibrillation (AF. Due to lack of contrast differentiation between the area of interest and surrounding structures in a moving organ like heart, there is a lack of proper intraprocedural guidance using current imaging techniques for ablation. Cardiac image registration is currently under investigation and is in clinical use for AF ablation. Cardiac image registration, which involves integration of two images in the context of the left atrium (LA, is intermodal, with the acquired image and the real-time reference image residing in different image spaces, and involves optimization, where one image space is transformed into the other. Unlike rigid body registration, cardiac image registration is unique and challenging due to cardiac motion during the cardiac cycle and due to respiration. This review addresses the basic principles of the emerging technique of registration and the inherent limitations as they relate to cardiac imaging and registration.

  2. Outflows from dynamo-active protostellar accretion discs

    CERN Document Server

    Von Rekowski, B; Dobler, W; Shukurov, A M; Brandenburg, Axel; Dobler, Wolfgang; Rekowski, Brigitta von; Shukurov, Anvar

    2003-01-01

    An axisymmetric model of a cool, dynamo-active accretion disc is applied to protostellar discs. Thermally and magnetically driven outflows develop that are not collimated within 0.1 AU. In the presence of a central magnetic field from the protostar, accretion onto the protostar is highly episodic, which is in agreement with earlier work.

  3. Asymmetric MHD Outflows/Jets from Accreting T Tauri Stars

    CERN Document Server

    Dyda, Sergei; Ustyugova, Galina V; Lii, Patrick S; Romanova, Marina M; Koldoba, Alexander V

    2015-01-01

    A large set of 2.5D MHD simulations has been carried out for axisymmetric viscous/diffusive disc accretion to rotating magnetized stars for the purpose of assessing the conditions where the outflows or jets are asymmetric relative to the equatorial plane. Observations of jets from young stellar objects reveal the asymmetric outflows from some sources. The considered initial magnetic fields are symmetric about the equatorial plane and consist of a radially distributed field threading the disc (disc-field) and a stellar dipole field. (1). For pure disc-fields the symmetry or asymmetry of the outflows is affected by the midplane plasma $\\beta$ of the disc. For the low density discs with small plasma $\\beta$ values, outflows are observed to be symmetric about the equatorial plane to within 10% over timescales of hundreds of inner disc orbits. For the denser higher $\\beta$ discs, the coupling of the upper and lower coronal plasmas is broken, and quasi-periodic field motion in the two hemispheres becomes different....

  4. Molecular Gas in M82 Resolving the Outflow and Streamers

    CERN Document Server

    Walter, F; Scoville, N Z; Walter, Fabian; Weiss, Axel; Scoville, Nick

    2002-01-01

    We present a high-resolution (3.6'', 70pc) CO(1-0) mosaic of the molecular gas in M 82 covering an area of 2.5' x 3.5' (2.8kpc x 3.9kpc) obtained with the OVRO millimeter interferometer. The observations reveal the presence of huge amounts of molecular gas (> 70% of the total molecular mass, M_tot=1.3 x 10^9 M_sun) outside the central 1 kpc disk. Molecular streamers are detected in and below M82's disk out to distances from the center of 1.7 kpc. Some of these streamers are well correlated with optical absorption features; they form the basis of some of the prominent tidal HI features around M 82. This provides evidence that the molecular gas within M 82's optical disk is disrupted by the interaction with M 81. Molecular gas is found in M 82's outflow/halo, reaching distances up to 1.2 kpc below the plane; CO line-splitting has been detected for the first time in the outflow. The maximum outflow velocity is 230 km/s; we derive an opening angle of 55 deg for the molecular outflow cone. The total amount of gas ...

  5. THE JET-DRIVEN BOW SHOCK IN OUTFLOWS

    Institute of Scientific and Technical Information of China (English)

    ZhangQing; ZhengXingwu

    1999-01-01

    Recent high resolution observations show the high collimated bipolar molecular outflows from young stellar objects, such as NGC 2 264G and NGC 2 024. Existing models can not yet give complete interpretations of the structure and properties of the observed flow. Here, we propose a jet-driven bow

  6. Complex Molecules in the L1157 Molecular Outflow

    CERN Document Server

    Arce, Héctor G; J\\orgensen, Jes K; Tafalla, Mario; Bachiller, Rafael

    2008-01-01

    We report the detection of complex organic molecules in the young protostellar outflow L1157. We identify lines from HCOOCH3, CH3CN, HCOOH and C2H5OH at the position of the B1 shock in the blueshifted lobe, making it the first time that complex species have been detected towards a molecular outflow powered by a young low-mass protostar. The time scales associated with the warm outflow gas (< 2,000 yr) are too short for the complex molecules to have formed in the gas phase after the shock-induced sputtering of the grain mantles. It is more likely that the complex species formed in the surface of grains and were then ejected from the grain mantles by the shock. The formation of complex molecules in the grains of low-mass star forming regions must be relatively efficient, and our results show the importance of considering the impact of outflows when studying complex molecules around protostars. The relative abundance with respect to methanol of most of the detected complex molecules is similar to that of hot ...

  7. Triggering the Formation of Halo Globular Clusters with Galaxy Outflows

    CERN Document Server

    Scannapieco, E; Harlow, F; Scannapieco, Evan; Weisheit, Jon; Harlow, Francis

    2004-01-01

    We investigate the interactions of high-redshift galaxy outflows with low-mass virialized (Tvir 20% of the cloud. Such estimates ignore the likely presence of large-scale vortices, however, which would further enhance turbulence generation. Thus quantitative mixing predictions must await more detailed numerical studies.

  8. Fast outflows and star formation quenching in quasar host galaxies

    CERN Document Server

    Carniani, S; Maiolino, R; Balmaverde, B; Brusa, M; Cano-Díaz, M; Cicone, C; Comastri, A; Cresci, G; Fiore, F; Feruglio, C; La Franca, F; Mainieri, V; Mannucci, F; Nagao, T; Netzer, H; Piconcelli, E; Risaliti, G; Schneider, R; Shemmer, O

    2016-01-01

    Negative feedback from active galactic nuclei (AGN) is considered a key mechanism in shaping galaxy evolution. Fast, extended outflows are frequently detected in the AGN host galaxies at all redshifts and luminosities, both in ionised and molecular gas. However, these outflows are only "potentially" able to quench star formation and we are still missing a decisive evidence of negative feedback in action. Here we present Spectrograph for INtegral Field Observations in the Near Infrared (SINFONI) H- and K-band integral-field spectroscopic observations of two quasars at $z\\sim$2.4 characterised by fast, extended outflows detected through the [OIII]$\\lambda$5007 line (Carniani et al. 2015). The high signal-to-noise ratio of our observations allows us to identify faint narrow (FWHM $< 500$ km/s), and spatially extended components in [OIII]$\\lambda$5007 and H$\\alpha$ emission associated with star formation in the host galaxy. Such star-formation powered emission is spatially anti-correlated with the fast outflow...

  9. Large sea ice outflow into the Nares Strait in 2007

    DEFF Research Database (Denmark)

    Kwok, R.; Pedersen, L.T.; Gudmandsen, Preben;

    2010-01-01

    at Fram Strait. Clearly, the ice arches control Arctic sea ice outflow. The duration of unobstructed flow explains more than 84% of the variance in the annual area flux. In our record, seasonal stoppages are always associated with the formation of an arch near the same location in the southern Kane...

  10. Radiation pressure confinement - IV. Application to broad absorption line outflows

    CERN Document Server

    Baskin, Alexei; Stern, Jonathan

    2014-01-01

    A fraction of quasars present broad absorption lines, produced by outflowing gas with typical velocities of 3000 - 10,000 km/s. If the outflowing gas fills a significant fraction of the volume where it resides, then it will be highly ionized by the quasar due to its low density, and will not produce the observed UV absorption. The suggestion that the outflow is shielded from the ionizing radiation was excluded by recent observations. The remaining solution is a dense outflow with a filling factor $f<10^{-3}$. What produces such a small $f$? Here we point out that radiation pressure confinement (RPC) inevitably leads to gas compression and the formation of dense thin gas sheets/filaments, with a large gradient in density and ionization along the line of sight. The total column of ionized dustless gas is a few times $10^{22}$ cm$^{-2}$, consistent with the observed X-ray absorption and detectable P V absorption. The predicted maximal columns of various ions show a small dependence on the system parameters, a...

  11. Tracing Inflows and Outflows with Absorption Lines in Circumgalactic Gas

    CERN Document Server

    Ford, Amanda Brady; Oppenheimer, Benjamin D; Katz, Neal; Kollmeier, Juna A; Thompson, Robert; Weinberg, David H

    2013-01-01

    We examine how HI and metal absorption lines within low-redshift galaxy halos trace the dynamical state of circumgalactic gas, using cosmological hydrodynamic simulations that include a well-vetted heuristic model for galactic outflows. We categorize inflowing, outflowing, and ambient gas based on its history and fate as tracked in our simulation. Following our earlier work showing that the ionisation level of absorbers was a primary factor in determining the physical conditions of absorbing gas, we show here that it is also a governing factor for its dynamical state. Low-ionisation metal absorbers (e.g. MgII) tend to arise in gas that will fall onto galaxies within several Gyr, while high-ionisation metal absorbers (e.g. OVI) generally trace material that was deposited by outflows many Gyr ago. Inflowing gas is dominated by enriched material that was previously ejected in an outflow, hence accretion at low redshifts is typically substantially enriched. Recycling wind material is preferentially found closer t...

  12. Unipolar outflows and global meridional circulations in rotating accretion flows

    CERN Document Server

    Igumenshchev, I V

    1999-01-01

    Using two-dimensional simulations of non-radiative viscous rotating black hole accretion flows, we show that the flows with alpha~0.1-0.3 self-organize to form stationary unipolar or bipolar outflows accompanied by global meridional circulations. The required energy comes, with efficiency implications are discussed.

  13. The Physics and Physical Properties of Quasar Outflows

    CERN Document Server

    Hamann, Fred; Chartas, George; McGraw, Sean; Hidalgo, Paola Rodriguez; Shields, Joseph; Charlton, Jane; Eracleous, Michael

    2013-01-01

    We describe two studies designed to characterize the total column densities, kinetic energies, and acceleration physics of broad absorption line (BAL) outflows in quasars. The first study uses new Chandra X-ray and ground-based rest-frame UV observations of 7 quasars with mini-BALs at extreme high speeds, in the range 0.1c to 0.2c, to test the idea that strong radiative shielding is needed to moderate the mini-BAL ionizations and facilitate their acceleration to extreme speeds. We find that the X-ray absorption is weak or absent, with generally N_H 15% of the UV continuum source along our lines of sight (based on measured line depths), then the radial thickness of these outflows is only Delta_R 8 x 10^15 cm. Thus the outflow regions have the shape of very thin "pancakes" viewed face-on, or they occupy larger volumes like a spray of dense cloudlets with a very small volume filling factor. We speculate that this situation (with ineffective shielding and small dense outflow substructures) applies to most quasar...

  14. Modeling jet and outflow feedback during star cluster formation

    CERN Document Server

    Federrath, Christoph; Banerjee, Robi; Klessen, Ralf S

    2014-01-01

    Powerful jets and outflows are launched from the protostellar disks around newborn stars. These outflows carry enough mass and momentum to transform the structure of their parent molecular cloud and to potentially control star formation itself. Despite their importance, we have not been able to fully quantify the impact of jets and outflows during the formation of a star cluster. The main problem lies in limited computing power. We would have to resolve the magnetic jet-launching mechanism close to the protostar and at the same time follow the evolution of a parsec-size cloud for a million years. Current computer power and codes fall orders of magnitude short of achieving this. In order to overcome this problem, we implement a subgrid-scale (SGS) model for launching jets and outflows, which demonstrably converges and reproduces the mass, linear and angular momentum transfer, and the speed of real jets, with ~ 1000 times lower resolution than would be required without SGS model. We apply the new SGS model to t...

  15. Evidence for a chemically differentiated outflow in Mrk 231

    CERN Document Server

    Lindberg, J E; Muller, S; Martí-Vidal, I; Falstad, N; Costagliola, F; Henkel, C; van der Werf, P; García-Burillo, S; González-Alfonso, E

    2015-01-01

    Aims: Our goal is to study the chemical composition of the outflows of active galactic nuclei and starburst galaxies. Methods: We obtained high-resolution interferometric observations of HCN and HCO$^+$ $J=1\\rightarrow0$ and $J=2\\rightarrow1$ of the ultraluminous infrared galaxy Mrk~231 with the IRAM Plateau de Bure Interferometer. We also use previously published observations of HCN and HCO$^+$ $J=1\\rightarrow0$ and $J=3\\rightarrow2$, and HNC $J=1\\rightarrow0$ in the same source. Results: In the line wings of the HCN, HCO$^+$, and HNC emission, we find that these three molecular species exhibit features at distinct velocities which differ between the species. The features are not consistent with emission lines of other molecular species. Through radiative transfer modelling of the HCN and HCO$^+$ outflow emission we find an average abundance ratio $X(\\mathrm{HCN})/X(\\mathrm{HCO}^+)\\gtrsim1000$. Assuming a clumpy outflow, modelling of the HCN and HCO$^+$ emission produces strongly inconsistent outflow masses....

  16. Onset of Mediterranean outflow into the North Atlantic

    NARCIS (Netherlands)

    Hermández-Molina, F.J.; Stow, D.A.V.; Alvarez-Zarikian, C.A.; Acton, G.; Bahr, A.; Balestra, B.; Ducassou, E.; Flood, R.; Flores, J.-A.; Furota, S.; Grunert, P.; Hodell, D.; Jimenez-Espejo, F.; Kim, J.K.; Krissek, L.; Kuroda, J.; Li, B.; Llave, E.; Lofi, J.; Lourens, L.; Miller, M.; Nanayama, F.; Nishida, N.; Richter, C.; Roque, C.; Pereira, H.; Sanchez Goñi, M.F.; Sierro, F.J.; Singh, A.D.; Takashimizu, Y.; Tzanova, A.; Voelker, A.; Williams, T.; Xuan, C.

    2014-01-01

    Sediments cored along the southwestern Iberian margin during Integrated Ocean Drilling Program Expedition 339 provide constraints on Mediterranean Outflow Water (MOW) circulation patterns from the Pliocene epoch to the present day. After the Strait of Gibraltar opened (5.33 million years ago), a lim

  17. Chandra Observations of Outflows from PSR J1509-5850

    CERN Document Server

    Klingler, Noel; Rangelov, Blagoy; Pavlov, George G; Posselt, Bettina; Ng, C -Y

    2016-01-01

    PSR J1509-5850 is a middle-aged pulsar with the period P ~ 89 ms, spin-down power Edot = 5.1 x 10^35 erg/s, at a distance of about 3.8 kpc. We report on deep Chandra X-ray Observatory observations of this pulsar and its pulsar wind nebula (PWN). In addition to the previously detected tail extending up to 7' southwest from the pulsar (the southern outflow), the deep images reveal a similarly long, faint diffuse emission stretched toward the north (the northern outflow) and the fine structure of the compact nebula (CN) in the pulsar vicinity. The CN is resolved into two lateral tails and one axial tail pointing southwest (a morphology remarkably similar to that of the Geminga PWN), which supports the assumption that the pulsar moves towards the northeast. The luminosities of the southern and northern outflows are about 1 x 10^33 and 4 x 10^32 erg/s, respectively. The spectra extracted from four regions of the southern outflow do not show any softening with increasing distance from the pulsar. The lack of synchr...

  18. Fueling AGN II: Spatially Resolved Molecular Inflows and Outflows

    CERN Document Server

    Davies, R I; Hicks, E K S; Emsellem, E; Erwin, P; Burtscher, L; Dumas, G; Lin, M; Malkan, M A; Mueller-Sanchez, F; de Xivry, G Orban; Rosario, D J; Schnorr-Mueller, A; Tran, A

    2014-01-01

    We analyse the 2-dimensional distribution and kinematics of the stars as well as molecular and ionised gas in the central few hundred parsecs of 5 active and 5 matched inactive galaxies. The equivalent widths of the Br-gamma line indicate there is no on-going star formation in their nuclei, although recent (terminated) starbursts are possible in the active galaxies. The stellar velocity fields show no signs of non-circular motions, while the 1-0S(1) H_2 kinematics exhibit significant deviations from simple circular rotation. In the active galaxies the H_2 kinematics reveal inflow and outflow superimposed on disk rotation. Steady-state circumnuclear inflow is seen in three AGN, and hydrodynamical models indicate it can be driven by a large scale bar. In three of the five AGN, molecular outflows are spatially resolved. The outflows are oriented such that they intersect, or have an edge close to, the disk - which may be the source of molecular gas in the outflow. The relatively low speeds imply the gas will fall...

  19. Possible Outflow Formation in the Central Engine of GRBs

    Indian Academy of Sciences (India)

    Tong Liu; Wei-Min Gu; Ju-Fu Lu

    2011-03-01

    We investigate the vertical structure of neutrino-dominated accretion flows in spherical coordinates. In our calculation, the empty funnel along the rotation axis can naturally explain the neutrino annihilable ejection. The outflow is possible due to the positive Bernoulli function, and the luminosity of neutrino annihilation is enhanced by one or two orders of magnitude.

  20. Protostellar Jets Enclosed by Low-velocity Outflows

    CERN Document Server

    Machida, Masahiro N

    2014-01-01

    A protostellar jet and outflow are calculated for \\sim 270 yr following the protostar formation using a three dimensional magnetohydrodynamics simulation, in which both the protostar and its parent cloud are spatially resolved. A high-velocity (\\sim100km/s) jet with good collimation is driven near the disk's inner edge, while a low-velocity (<10km/s) outflow with a wide opening angle appears in the outer-disk region. The high-velocity jet propagates into the low-velocity outflow, forming a nested velocity structure in which a narrow high-velocity flow is enclosed by a wide low-velocity flow. The low-velocity outflow is in a nearly steady state, while the high-velocity jet appears intermittently. The time-variability of the jet is related to the episodic accretion from the disk onto the protostar, which is caused by gravitational instability and magnetic effects such as magnetic braking and magnetorotational instability. Although the high-velocity jet has a large kinetic energy, the mass and momentum of the...

  1. Methanol Maser Associated Outflows: Detection statistics and properties

    CERN Document Server

    de Villiers, H M; Thompson, M A; Ellingsen, S P; Urquhart, J S; Breen, S L; Burton, M G; Csengeri, T; Ward-Thompson, D

    2014-01-01

    We have selected the positions of 54 6.7GHz methanol masers from the Methanol Multibeam Survey catalogue, covering a range of longitudes between $20^{\\circ}$ and $34^{\\circ}$ of the Galactic Plane. These positions were mapped in the J=3-2 transition of both the $\\rm{^{13}CO}$ and $\\rm{C^{18}O}$ lines. A total of 58 $\\rm{^{13}CO}$ emission peaks are found in the vicinity of these maser positions. We search for outflows around all $\\rm{^{13}CO}$ peaks, and find evidence for high-velocity gas in all cases, spatially resolving the red and blue outflow lobes in 55 cases. Of these sources, 44 have resolved kinematic distances, and are closely associated with the 6.7GHz masers, a sub-set referred to as Methanol Maser Associated Outflows (MMAOs). We calculate the masses of the clumps associated with each peak using 870 $\\rm{\\mu m}$ continuum emission from the ATLASGAL survey. A strong correlation is seen between the clump mass and both outflow mass and mechanical force, lending support to models in which accretion is...

  2. Fort Donelson National Battlefield Tract & Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  3. Piscataway Park Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  4. Cowpens National Battlefield Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  5. Petersburg National Battlefield Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  6. Pipestone National Monument Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  7. Catoctin Mountain Park Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  8. Hovenweep National Monument Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  9. Sequoia National Park Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  10. Navajo National Monument Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  11. Chiricahua National Monument Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  12. Alagnak Wild River Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that were created by the Land Resources Division. Tracts are numbered and created by the...

  13. Coronado National Memorial Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  14. Chamizal National Memorial Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  15. Antietam National Battlefield Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  16. Pinnacles National Monument Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  17. Vietnam Vetrans Memorial Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  18. Theodore Roosevelt Island Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  19. Colorado National Monument Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  20. Noatak National Preserve Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that were created by the Land Resources Division. Tracts are numbered and created by the...

  1. Haleakala National Park Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  2. Canyonlands National Park Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  3. Cranberry Juice for Urinary Tract Infection?

    Science.gov (United States)

    ... nih.gov/medlineplus/news/fullstory_157466.html Cranberry Juice for Urinary Tract Infection? Specialist says grocery-store ... 2016 (HealthDay News) -- Contrary to popular belief, cranberry juice does not cure a urinary tract infection, a ...

  4. Badlands National Park Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  5. Saguaro National Park Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  6. Mojave National Preserve Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  7. Boundaries, Tracts (Published 2006), Petrified Forest, AZ

    Data.gov (United States)

    National Park Service, Department of the Interior — This is an ESRI shapefile of National Park Service tract data. Tracts are numbered and created by the regional cartographic staff at the Land Resources Program...

  8. Wupatki National Monument Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  9. Atmospheric outflow of nutrients to the Bay of Bengal: Impact of anthropogenic sources..

    Digital Repository Service at National Institute of Oceanography (India)

    Srinivas, B.; Sarin, M.M.; Sarma, V.V.S.S.

    outflow show pronounced temporal variability. The inorganic nitrogen (NH4 + -N: ~90% of NInorg) dominates the total soluble nitrogen (NTot). Although the contribution of organic nitrogen is not significant, the mass ratio of NOrg/NTotin the outflow varied...

  10. Structure and Nuclear Composition of General Relativistic, Magnetohydrodynamic Outflows from Neutrino-Cooled Disks

    CERN Document Server

    Barzilay, Yudith

    2007-01-01

    We compute the structure and degree of neutronization of general relativistic magnetohydrodynamic (GRMHD) outflows originating from the inner region of neutrino-cooled disks. We consider both, outflows expelled from a hydrostatic disk corona and outflows driven by disk turbulence. We show that in outflows driven thermally from a static disk the electron fraction quickly evolves to its equilibrium value which is dominated by neutrino capture. Those outflows are generally proton rich and, under certain conditions, can be magnetically dominated. They may also provide sites for effective production of 56Ni. Centrifugally driven outflows and outflows driven by disk turbulence, on the other hand, can preserve the large in-disk neutron excess. Those outflows are, quite generally, subrelativistic by virtue of the large mass flux driven by the additional forces.

  11. Postoperative cardiac arrest due to cardiac surgery complications

    International Nuclear Information System (INIS)

    To examine the role of anesthetists in the management of cardiac arrest occurring in association with cardiac anesthesia. In this retrospective study we studied the potential performances for each of the relevant incidents among 712 patients undergoing cardiac operations at Golestan and Naft Hospitals Ahwaz between November 2006 and July 2008. Out of total 712 patients undergoing cardiac surgery, cardiac arrest occurred in 28 cases (3.9%) due to different postoperative complications. This included massive bleeding (50% of cardiac arrest cases, 1.9% of patients); pulseless supra ventricular tachycardia (28.5% of cardiac arrest cases, 1.1% of patients); Heart Failure (7% of cardiac arrest cases, 0.2% of patients); Aorta Arc Rapture (3.5% of cardiac arrest cases, 0.1% of patients); Tamponade due to pericardial effusion (3.5% of cardiac arrest cases, 0.1% of total patients); Right Atrium Rupture (3.5% of cardiac arrest cases, 0.1% of patients) were detected after cardiac surgery. Out of 28 cases 7 deaths occurred (25% of cardiac arrest cases, 0.1% of patients). The most prevalent reason for cardiac arrest during post operative phase was massive bleeding (50%) followed by pulseless supra ventricular tachycardia (28.5%). Six patients had some morbidity and the remaining 15 patients recovered. There are often multiple contributing factors to a cardiac arrest under cardiac anesthesia, as much a complete systematic assessment of the patient, equipment, and drugs should be completed. We also found that the diagnosis and management of cardiac arrest in association with cardiac anesthesia differs considerably from that encountered elsewhere. (author)

  12. Multiwavelength Spectroscopy of the Bipolar Outflow from Cepheus E

    Science.gov (United States)

    Smith, Michael D.; Froebrich, Dirk; Eislöffel, Jochen

    2003-07-01

    Cepheus E is the site of an exceptional example of a protostellar outflow with a very young dynamical age and extremely high near-infrared luminosity. We combine molecular spectroscopic data from the submillimeter to the near-infrared in order to interpret the rotational excitation of CO and the rovibrational excitation of H2. We conclude that C-type shocks with a paraboloidal bow shock geometry can simultaneously explain all the molecular excitations. Extinction accounts for the deviation of the column densities from local thermodynamic equilibrium. A difference in the extinction between the red- and blueshifted outflow lobes may account for the measured flux difference. The outflow is deeply embedded in a clump of density 105 cm-3, yet a good fraction of atomic hydrogen, about 40%, is required to explain the excitation and statistical equilibrium. We propose that this atomic component arises, self-consistently, from the dissociated gas at the apex of the leading bow shocks and the relatively long molecule reformation time. At least 20 bow shocks are required in each lobe, although these may be subdivided into smaller bows and turbulent shocked regions. The total outflow mechanical power and cooling amounts to over 30 Lsolar, almost half the source's bolometric luminosity. Nevertheless, only about 6% of the clump mass has been set in outward motion by the outflow, allowing a collapse to continue. Based on observations with ISO, an ESA project with instruments funded by ESA Member States (especially the PI countries: France, Germany, the Netherlands and the United Kingdom) and with the participation of ISAS and NASA.

  13. Overconsumption, outflows and the quenching of satellite galaxies

    Science.gov (United States)

    McGee, Sean L.; Bower, Richard G.; Balogh, Michael L.

    2014-07-01

    The baryon cycle of galaxies is a dynamic process involving the intake, consumption and ejection of vast quantities of gas. In contrast, the conventional picture of satellite galaxies has them methodically turning a large gas reservoir into stars until this reservoir is forcibly removed due to external ram pressure. This picture needs revision. Our modern understanding of the baryon cycle suggests that in some regimes the simple interruption of the fresh gas supply may quench satellite galaxies long before stripping events occur, a process we call overconsumption. We compile measurements from the literature of observed satellite quenching times at a range of redshifts to determine if satellites are principally quenched through orbit-based gas stripping events - either direct stripping of the disc (ram pressure stripping) or the extended gas halo (strangulation) - or from internally driven star formation outflows via overconsumption. These time-scales show significant deviations from the evolution expected for gas stripping mechanisms and suggest that either ram pressure stripping is much more efficient at high redshift, or that secular outflows quench satellites before orbit-based stripping occurs. Given the strong redshift evolution of star formation rates, at high redshift even moderate outflow rates will lead to extremely short delay times with the expectation that high-redshift (z > 1.5) satellites will be quenched almost immediately following the cessation of cosmological inflow. Observations of high-redshift satellites give an indirect but sensitive measure of the outflow rate, with current measurements suggesting that outflows are no larger than 2.5 times the star formation rate for galaxies with a stellar mass of 1010.5 M⊙.

  14. Cerebrospinal fluid outflow along lumbar nerves and possible relevance for pain research: case report and review

    OpenAIRE

    Bechter, Karl; Schmitz, Bernd

    2014-01-01

    CSF outflow through the cribriform plate near the olfactory nerves and the outflow along brain and spinal nerves are together known as peripheral CSF outflow pathway (PCOP). It is still not clear whether the PCOP has pathogenetic relevance. Our previous clinical observations have indicated that CSF may interact with nerves along the PCOP and in this article we present our finding of CSF outflow demonstrated by myelography in a single patient. We also discuss unexplained experimental pain path...

  15. Generation of shockwave and vortex structures at the outflow of a boiling water jet

    Science.gov (United States)

    Alekseev, M. V.; Lezhnin, S. I.; Pribaturin, N. A.; Sorokin, A. L.

    2014-12-01

    Results of numerical simulation for shock waves and generation of vortex structures during unsteady outflow of boiling liquid jet are presented. The features of evolution of shock waves and vortex structures formation during unsteady outflow of boiling water are compared with corresponding structures during unsteady gas outflow.

  16. Urinary Tract Infections In Pregnancy

    OpenAIRE

    N Sivalingam; Loh KY

    2007-01-01

    Urinary tract infections frequently affect pregnant mothers. This problem causes significant morbidity and healthcare expenditure. Three common clinical manifestations of UTIs in pregnancy are: asymptomatic bacteriuria, acute cystitis and acute pyelonephritis. Escherichia coli remains the most frequent organism isolated in UTIs. All pregnant mothers should be screened for UTIs in pregnancy and antibiotics should be commenced without delay. Urine culture and sensitivity is the gold standard in...

  17. Approach to urinary tract infections

    OpenAIRE

    Najar, M S; Saldanha, C. L.; Banday, K. A.

    2009-01-01

    Urinary tract infection (UTI) is the most common infection experienced by humans after respiratory and gastro-intestinal infections, and also the most common cause of both community-acquired and nosocomial infections for patients admitted to hospitals. For better management and prognosis, it is mandatory to know the possible site of infection, whether the infection is uncomplicated or complicated, re-infection or relapse, or treatment failure and its pathogenesis and risk factors. Asymptomati...

  18. Diet and biliary tract cancer

    OpenAIRE

    Moerman CJ; Bueno de Mesquita HB; Runia S; Smeets FWM

    1991-01-01

    We studied the relation between diet and biliary tract cancer in a case-control study, comprising 111 incident cases and 480 controls from the general population. Food intake was assessed with a semi- quantitative food frequency questionnaire, which covered diet comprehensively. In half of the cases and 30% of the controls the information was obtained from the spouse or other relatives (indirect respondents). Mono- and disaccharides showed an elevated risk, independent from other sources of e...

  19. Effect of Cerium on Cardiac Muscle of Rat and Guinea Pig

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The effect of Ce3+ on cardiac muscle of rat and guinea pig was studied. In vitro, 0.05 mmol.L-1 solution of Ce3+ inhibited the contraction of guinea pig atria. The change of action potential duration(APD) of guinea pig papillary muscle exposed to 0.4 mmol·L-1 Ce3+ was significant, and those exposed to 0.1 and 0.2 mmol·L-1 Ce3+ were not significant. In vivo, compared with the control group, the APD for rat cardiac muscle after long-term feed on Ce3+ was significantly delayed in high dose, and that was not significantly delayed in low dose. The results suggest that Ce3+ with long-term high dose intake might affect the influx of Ca2+, Na+ and outflow of K+ for rat cardiac muscle.

  20. Trasplante de homoinjertos valvulares cardiacos y vasculares Cardiac and vascular homograft valves transplant

    Directory of Open Access Journals (Sweden)

    J. M. Herreros

    2006-08-01

    for heart transplant; c Cadaver donors with asystolia of less than 8 hours. Homograft cardiac valves are the substitute of choice in aortic valve endocarditis, patients with counter-indications for anticoagulation, reconstruction of the outflow tract of the right ventricle, aortic valve replacement in children and young adults through the Ross operation, and an optional indication is the aortic valve and/or rising aorta replacement in patients over 60 years of age. Although there are not sufficiently broad series of homogratfs with arterial substitutes, with respect to the number of patients and time of evolution, the results suggest that this can benefit patients with vascular infection, immunodepressed patients or complex patients whose technique during the operation might require a homograft.

  1. A young bipolar outflow from IRAS 15398-3359

    Science.gov (United States)

    Bjerkeli, P.; Jørgensen, J. K.; Brinch, C.

    2016-03-01

    Context. Changing physical conditions in the vicinity of protostars allow for a rich and interesting chemistry to occur. Heating and cooling of the gas allows molecules to be released from and frozen out on dust grains. These changes in physics, traced by chemistry as well as the kinematical information, allows us to distinguish between different scenarios describing the infall of matter and the launching of molecular outflows and jets. Aims: We aim to determine the spatial distribution of different species that are of different chemical origin. This is to examine the physical processes in play in the observed region. From the kinematical information of the emission lines we aim to determine the nature of the infalling and outflowing gas in the system. We also aim to determine the physical properties of the outflow. Methods: Maps from the Submillimeter Array (SMA) reveal the spatial distribution of the gaseous emission towards IRAS 15398-3359. The line radiative transfer code LIME is used to construct a full 3D model of the system taking all relevant components and scales into account. Results: CO, HCO+, and N2H+ are detected and shown to trace the motions of the outflow. For CO, the circumstellar envelope and the surrounding cloud also have a profound impact on the observed line profiles. N2H+ is detected in the outflow, but is suppressed towards the central region, perhaps because of the competing reaction between CO and H3+ in the densest regions as well as the destruction of N2H+ by CO. N2D+ is detected in a ridge south-west of the protostellar condensation and is not associated with the outflow. The morphology and kinematics of the CO emission suggests that the source is younger than ~1000 years. The mass, momentum, momentum rate, mechanical luminosity, kinetic energy, and mass-loss rate are also all estimated to be low. A full 3D radiative transfer model of the system can explain all the kinematical and morphological features in the system.

  2. Immune cells in the female reproductive tract.

    Science.gov (United States)

    Lee, Sung Ki; Kim, Chul Jung; Kim, Dong-Jae; Kang, Jee-Hyun

    2015-02-01

    The female reproductive tract has two main functions: protection against microbial challenge and maintenance of pregnancy to term. The upper reproductive tract comprises the fallopian tubes and the uterus, including the endocervix, and the lower tract consists of the ectocervix and the vagina. Immune cells residing in the reproductive tract play contradictory roles: they maintain immunity against vaginal pathogens in the lower tract and establish immune tolerance for sperm and an embryo/fetus in the upper tract. The immune system is significantly influenced by sex steroid hormones, although leukocytes in the reproductive tract lack receptors for estrogen and progesterone. The leukocytes in the reproductive tract are distributed in either an aggregated or a dispersed form in the epithelial layer, lamina propria, and stroma. Even though immune cells are differentially distributed in each organ of the reproductive tract, the predominant immune cells are T cells, macrophages/dendritic cells, natural killer (NK) cells, neutrophils, and mast cells. B cells are rare in the female reproductive tract. NK cells in the endometrium significantly expand in the late secretory phase and further increase their number during early pregnancy. It is evident that NK cells and regulatory T (Treg) cells are extremely important in decidual angiogenesis, trophoblast migration, and immune tolerance during pregnancy. Dysregulation of endometrial/decidual immune cells is strongly related to infertility, miscarriage, and other obstetric complications. Understanding the immune system of the female reproductive tract will significantly contribute to women's health and to success in pregnancy. PMID:25713505

  3. Assessment of a single monomorphic ventricular ectopy from the right ventricular outflow tract in standard and high resolution electrocardiogram

    OpenAIRE

    Kozłowski, Dariusz; Kosiński, Adam; Dąbrowska-Kugacka, Alicja; Lewicka-Nowak, Ewa; Dudziak, Maria; Grzybiak, Marek; Raczak, Grzegorz

    2010-01-01

    Introduction High-resolution electrocardiography (ECG-CREM) is a method based on digital electrocardiography. In order to facilitate the interpretation of the Crem records the technique of vectorcardiography was used. In comparison the origin of the ventricular premature complexes (VPCs) could be estimated based on a standard 12-lead electrocardiogram. The aim of the study was to assess the point of origin of the VPCs in ECG-CREM and correlate it with standard electrocardiography (ECG-Stand)....

  4. AGN-driven outflows without immediate quenching in simulations of high-redshift disk galaxies

    OpenAIRE

    Gabor, Jared M.; Bournaud, Frédéric

    2014-01-01

    We study outflows driven by Active Galactic Nuclei (AGNs) using high- resolution simulations of idealized z=2 isolated disk galaxies. Episodic accretion events lead to outflows with velocities >1000 km/s and mass outflow rates up to the star formation rate (several tens of Msun/yr). Outflowing winds escape perpendicular to the disk with wide opening angles, and are typically asymmetric (i.e. unipolar) because dense gas above or below the AGN in the resolved disk inhibits outflow. Owing to rap...

  5. Pediatric cardiac postoperative care

    Directory of Open Access Journals (Sweden)

    Auler Jr. José Otávio Costa

    2002-01-01

    Full Text Available The Heart Institute of the University of São Paulo, Medical School is a referral center for the treatment of congenital heart diseases of neonates and infants. In the recent years, the excellent surgical results obtained in our institution may be in part due to modern anesthetic care and to postoperative care based on well-structured protocols. The purpose of this article is to review unique aspects of neonate cardiovascular physiology, the impact of extracorporeal circulation on postoperative evolution, and the prescription for pharmacological support of acute cardiac dysfunction based on our cardiac unit protocols. The main causes of low cardiac output after surgical correction of heart congenital disease are reviewed, and methods of treatment and support are proposed as derived from the relevant literature and our protocols.

  6. Application of cine cardiac MR imaging in normal subjects and patients with valvular, coronary artery, and aortic disease

    International Nuclear Information System (INIS)

    Cine MR imaging was performed on 15 normal subjects and 27 patients with cardiac disease. In normal subjects, high signal intensity of flowing blood contrasted with that of the myocardium. In 16 patients with valvular regurgitation, signal void jet due to turbulence was visualized across the diseased valves. In three IHSS patients, thickened LV myocardium, mitral regurgitant jets, and systolic LV outflow jets were noted. Five patients with myocardial infarction (MI) showed thinning and/or hypokinesis of MI regions. In three patients with Marfan syndrome, aortic dilatation, insufficiency, and flap (one pt) were identified. Cine MR imaging is potentially useful for evaluation of a variety of cardiac diseases

  7. Giant Cardiac Cavernous Hemangioma.

    Science.gov (United States)

    Unger, Eric; Costic, Joseph; Laub, Glenn

    2015-07-01

    We report the case of an asymptomatic giant cardiac cavernous hemangioma in a 71-year-old man. The intracardiac mass was discovered incidentally during surveillance for his prostate cancer; however, the patient initially declined intervention. On presentation to our institution 7 years later, the lesion had enlarged significantly, and the patient consented to excision. At surgery, an 8 × 6.5 × 4.8 cm intracardiac mass located on the inferior heart border was excised with an intact capsule through a median sternotomy approach. The patient had an uneventful postoperative course. We discuss the diagnostic workup, treatment, and characteristics of this rare cardiac tumor. PMID:26140782

  8. Discovery of superthermal hydroxyl (OH) in the HH211 outflow

    CERN Document Server

    Tappe, A; Black, J H; Muench, A A

    2008-01-01

    We present a 5-37 micron infrared spectrum obtained with the Spitzer Space Telescope toward the southeastern lobe of the young protostellar outflow HH211. The spectrum shows an extraordinary sequence of OH emission lines arising in highly excited rotational levels up to an energy E/k~28200K above the ground level. This is, to our knowledge, by far the highest rotational excitation of OH observed outside Earth. The spectrum also contains several pure rotational transitions of H2O (v=0), H2 (v=0) S(0) to S(7), HD (v=0) R(3) to R(6), and atomic fine-structure lines of [Fe II], [Si II], [Ne II], [S I], and [Cl I]. The origin of the highly excited OH emission is most likely the photodissociation of H2O by the UV radiation generated in the terminal outflow shock of HH211.

  9. The Influence of Outflow in Supercritical Accretion Flows

    Science.gov (United States)

    Zahra Zeraatgari, Fatemeh; Abbassi, Shahram; Mosallanezhad, Amin

    2016-06-01

    We solve the radiation-hydrodynamic equations of supercritical accretion flows in the presence of radiation force and outflow by using self-similar solutions. Similar to the pioneering works, in this paper we consider a power-law function for mass inflow rate as \\dot{M}\\propto {r}s. We found that s = 1 when the radiative cooling term is included in the energy equation. Correspondingly, the effective temperature profile with respect to the radius was obtained as {T}{eff}\\propto {r}-1/2. In addition, we investigated the influence of the outflow on the dynamics of the accretion flow. We also calculated the continuum spectrum emitted from the disk surface as well as the bolometric luminosity of the accretion flow. Furthermore, our results show that the advection parameter, f, depends strongly on mass inflow rate.

  10. The influence of outflow in supercritical accretion flows

    CERN Document Server

    Zeraatgari, Fatemeh Zahra; Mosallanezhad, Amin

    2016-01-01

    We solve the radiation-hydrodynamic (RHD) equations of supercritical accretion flows in the presence of radiation force and outflow by using self similar solutions. Compare with the pioneer works, in this paper we consider power-law function for mass inflow rate as $ \\dot{M} \\propto r^{s} $. We found that $ s = 1 $ when the radiative cooling term is included in the energy equation. Correspondingly, the effective temperature profile with respect to the radius was obtained as $ T_{\\text{eff}} \\varpropto r^{-1/2} $. In addition, we investigated the influence of the outflow on the dynamics of the accretion flow. We also calculated the continuum spectrum emitted from the disk surface as well as the bolometric luminosity of the accretion flow. Furthermore, our results show that the advection parameter, $ f $, strongly depends on mass inflow rate.

  11. On the Thermal Line Emission from the Outflows in Ultraluminous X-Ray Sources

    Science.gov (United States)

    Xu, Ya-Di; Cao, Xinwu

    2016-08-01

    The atomic features in the X-ray spectra of ultraluminous X-ray sources (ULXs) may be associated with the outflow, which may provide a way to explore the physics of the ULXs. We construct a conical outflow model and calculate the thermal X-ray Fe emission lines from the outflows. Our results show that thermal line luminosity decreases with increasing outflow velocity and/or opening angle of the outflow for a fixed kinetic power of the outflows. Assuming the kinetic power of the outflows to be comparable with the accretion power in the ULXs, we find that the equivalent width can be several eV for the thermal X-ray Fe emission line from the outflows in the ULXs with stellar-mass black holes. The thermal line luminosity is proportional to 1/M bh (M bh is the black hole mass of the ULX). The equivalent width decreases with the black hole mass, which implies that the Fe line emission from the outflows can hardly be detected if the ULXs contain intermediate-mass black holes. Our results suggest that the thermal X-ray Fe line emission should be preferentially be detected in the ULXs with high kinetic power slowly moving outflows from the accretion disks surrounding stellar-mass black holes/neutron stars. The recently observed X-ray atomic features of the outflows in a ULX may imply that it contains a stellar-mass black hole.

  12. Determinants of Foreign Direct Investments Outflow From a Developing Country: the Case of Turkey

    Directory of Open Access Journals (Sweden)

    Gokhan Onder

    2013-09-01

    Full Text Available Foreign direct investments (FDI outflows of Turkey have remarkably been raising over the last decade. This rapid increase brings about the need for questioning the determinants of FDI outflows. The aim of this paper is to estimate the factors affecting outflow FDI from Turkey from 2002 to 2011 by using Prais-Winsten regression analysis. According to estimation results, population, infrastructure, percapita gross domestic product of the host country, and home country exports to the host country are the factors having positive effects on outflow FDI. We found, on the other hand, that the annual inflation rate of the host country, its tax rate collected from commercial profit, and its distance from Turkey have a negative relation with investment outflows. Moreover our results show that while investment outflows to developed countries are in the form of horizontal investments, investment outflows to developing countries are in the form of vertical investments.

  13. Retreat of a Giant Cataract in a Martian Outflow Channel

    Science.gov (United States)

    Gupta, S.; Warner, N. H.; Kim, J.; Lin, S.; Muller, J.

    2010-12-01

    The circum-Chryse catastrophic outflow channels are the largest valley systems on Mars. Large-magnitude floods are widely considered to have eroded them primarily during the Hesperian epoch. Here we test the hypothesis that outflow channel erosion has been accomplished largely by upstream migration of large cataracts or knickpoints as a consequence of abrupt base-level changes. We describe the evolution of a ~600-m-deep tributary outflow channel to Ares Vallis, Mars. High-resolution topography, image analysis, and crater statistics indicate that this tributary canyon developed by the upstream migration of a large, ~300-m-tall cataract during multiple flood events that span ~1 Ga of Mars history (3.7 to 2.6 Ga). Issuing from Hydapsis Chaos, these floods were initiated at a similar time and occurred over a similar time range to flooding in Ares Vallis, suggesting a potential regional control on flood initiation and chaos formation. Additionally, we provide evidence that cataract retreat and significant incision within the tributary canyon occurred only after a series of down-cutting events within Ares Vallis. Topography data and crater statistics taken from the floor of Ares Vallis indicate a ~300 m base level drop that coincides temporally with an Early Amazonian (~2.6 Ga) flood event and cataract formation within the tributary canyon. The results both confirm the hypothesis of long-term, multiple flood events within martian outflow channels and demonstrate the influence of base-level change on their incision. We compare this martian cataract to terrestrial examples from megaflood terrain.

  14. Indirect detection of subsurface outflow from a Rift Valley lake

    OpenAIRE

    Darling, W. G.; Allen, D J; Armannsson, H.

    1990-01-01

    Naivasha, highest of the Kenya (Gregory) Rift Valley lakes, has no surface outlet. However, unlike other Rift lakes it has not become saline despite high potential evaporation rates, which indicates that there must be some subsurface drainage. The fate ofthis outflow has been the subject of speculation for many years, especially during the general decline in lake water level during the I980's. Particularly to the south of the lake, there are few opportunities to obtain information from direct...

  15. Estimation of cold plasma outflow during geomagnetic storms

    OpenAIRE

    Haaland, Stein; Eriksson, A.; Maes, L.; Baddeley, Lisa; A. Barakat; Chappell, R; Eccles, V.; Johnsen, C.; Lybekk, Bjørn; Li, K.; A. Pedersen; Schunk, R.; Welling, D.

    2016-01-01

    Low-energy ions of ionospheric origin constitute a significant contributor to the magnetospheric plasma population. Measuring cold ions is difficult though. Observations have to be done at sufficiently high altitudes and typically in regions of space where spacecraft attain a positive charge due to solar illumination. Cold ions are therefore shielded from the satellite particle detectors. Furthermore, spacecraft can only cover key regions of ion outflow during segments of their orbit, so addi...

  16. The gaseous environments of quasars: outflows, feedback & cold mode accretion

    Science.gov (United States)

    Chen, Chen

    2016-01-01

    We are interested in the early stages of massive galaxy formation at high redshifts, when cold mode accretion and outflows that drive galaxy-scale blowouts and feedback are expected to occur. It is quite possible that infall (e.g. cold mode accretion) and outflow (e.g. a blowout) occur together, leading to complex gas structures. We are conducting a study of rich complexes of narrow CIV absorption lines to find direct evidence for cold mode accretion and gaseous fragments shredded and dispersed by powerful outflows. Study of these rich complexes will provide us critical information of gas, such as velocity, ionization, metallicity, column density, kinetic energy, etc. The information could help us to understand the gas origins. We search SDSS, VLT and Keck archives for quasars with complex multi-component CIV systems or/and strong infalling systems. We obtain particular interesting results for the quasar Q0119-046. The spectra show rich infalling and partial covering complexes. The electron density of the gas is ~103.4 cm-3, and the gas is at a distance ~3.6 kpc from the central source. The gas is metal poor and seems to be infalling at the speed ~70 km/s into the galaxy. And it appears to partially cover the continuum source, requiring absorber size scales less than 0.01 pc. This result for very small clouds on galactic ($>$ kpc) scales is unusual but not unprecedented. It may provide evidence that the clouds are fragments from a shredded cloud, dispersed by an unseen high-speed quasar-driven outflow.

  17. NIHAO XI: Formation of Ultra-Diffuse Galaxies by outflows

    OpenAIRE

    Di Cintio, Arianna; Brook, Chris B.; Dutton, Aaron A.; Macciò, Andrea V.; Obreja, Aura C.; Dekel, Avishai

    2016-01-01

    We address the origin of Ultra-Diffuse Galaxies (UDGs), which have stellar masses typical of dwarf galaxies but effective radii of Milky Way-sized objects. Their formation mechanism, and whether they are failed $\\rm L_{\\star}$ galaxies or diffuse dwarfs, are challenging issues. Using zoom-in cosmological simulations from the NIHAO project, we show that UDG analogues form naturally in medium-mass haloes due to episodes of gas outflows associated with star formation. The simulated UDGs live in ...

  18. Radiography in cardiology [cardiac disorders, cardiac insufficiency

    International Nuclear Information System (INIS)

    The diagnostic procedure in cardiology nearly always requires an X-ray examination of the thorax. This examination is very informative when it is correctly performed and interpreted. The radiographs need to be read precisely and comprehensively: this includes the evaluation of the silhouette of the heart (size, form and position) as well as the examination of extra-cardiac thoracic structures allowing among other things to search for signs of cardiac insufficiency. The conclusion of the X-ray examination can be drawn after having brought together information concerning the case history, the clinical examination and the study of the radiographs. The radiologist finds himself in one of three situations: (1) the information provided by the X-ray pictures is characteristic of a disease and permits a diagnosis, (2) the X-ray pictures indicate a group of hypotheses; further complementary tests could be useful and (3) the X-ray pictures provide ambiguous even contradictory information; it is necessary to complete the radiological examination by other techniques such as an ultrasonographic study of the heart

  19. CLUSTERED STAR FORMATION AND OUTFLOWS IN AFGL 2591

    International Nuclear Information System (INIS)

    We report on a detailed study of the water maser kinematics and radio continuum emission toward the most massive and young object in the star-forming region AFGL 2591. Our analysis shows at least two spatial scales of multiple star formation, one projected across 0.1 pc on the sky and another one at about 2000 AU from a ZAMS star of about 38 M☉. This young stellar object drives a powerful jet- and wind-driven outflow system with the water masers associated to the outflow walls, previously detected as a limb-brightened cavity in the NIR band. At about 1300 AU to the north of this object a younger protostar drives two bow shocks, outlined by arc-like water maser emission, at 200 AU either side of the source. We have traced the velocity profile of the gas that expands along these arc-like maser structures and compared it with the jet-driven outflow model. This analysis suggests that the ambient medium around the northern protostar is swept up by a jet-driven shock (>66 km s–1) and perhaps a lower-velocity (∼10 km s–1) wind with an opening angle of about 20° from the jet axis.

  20. An Analytic Model of Galactic Winds and Mass Outflows

    Institute of Scientific and Technical Information of China (English)

    Cheng-Gang Shu; Hou-Jun Mo; Shu-De Mao

    2005-01-01

    Galactic winds and mass outflows are observed both in nearby starburst galaxies and in high-redshift star-forming galaxies. We develop a simple analytic model to understand the observed superwind phenomenon with a discussion of the model uncertainties. Our model is built upon the model of McKee & Ostriker for the interstellar medium. It allows one to predict how properties of a superwind,such as wind velocity and mass outflow rate, are related to properties of its star forming host galaxy, such as size, gas density and star formation rate. The model predicts a threshold of star formation rate density for the generation of observable galactic winds. Galaxies with more concentrated star formation activities produce superwinds with higher velocities. The predicted mass outflow rates are compara ble to (or slightly larger than) the corresponding star formation rates. We apply our model to both local starburst galaxies and high-redshift Lyman break galaxies, and find its predictions to be in good agreement with current observations. Our model is simple and so can be easily incorporated into numerical simulations and semi-analytical models of galaxy formation.

  1. An analytic model for the galactic winds and mass outflows

    CERN Document Server

    Shu, C; Mao, S; Shu, Chenggang; Mao, Shude

    2003-01-01

    Galactic winds and mass outflows are observed both in nearby starburst galaxies and in high-redshift star-forming galaxies. In this paper we develop a simple analytic model to understand the observed superwind phenomenon. Our model is built upon the model of McKee & Ostriker (1977) for the interstellar medium. It allows one to predict how properties of a superwind, such as wind velocity and mass outflow rate, are related to properties of its star-forming host galaxy, such as size, gas density and star formation rate. The model predicts a threshold of star formation rate density for the generation of observable galactic winds. Galaxies with more concentrated star formation produce superwinds with higher velocities. The predicted mass outflow rates are comparable to (or slightly larger than) the corresponding star formation rates. We apply our model to both local starburst galaxies and high-redshift Lyman break galaxies, and find its predictions to be in good agreement with current observations. Our model i...

  2. A young bipolar outflow from IRAS 15398-3359

    CERN Document Server

    Bjerkeli, P; Brinch, C

    2016-01-01

    Changing physical conditions in the vicinity of protostars allow for a rich and interesting chemistry to occur. Heating and cooling of the gas allows molecules to be released from and frozen out on dust grains. These changes in physics, traced by chemistry, as well as the kinematical information allows us to distinguish between different scenarios describing the infall of matter and the launching of molecular outflows and jets. We aim at determining the spatial distribution of different species, of different chemical origin. This is to examine the physical processes in play in the observed region. From the kinematical information of the emission lines we aim at determining the nature of the infalling and outflowing gas in the system. We also aim at determining the physical properties of the outflow. Maps from the Sub-Millimeter Array reveal the spatial distribution of the gaseous emission toward IRAS15398-3359. The line radiative transfer code LIME is used to construct a full 3D model of the system taking all...

  3. A Variable PV Broad Absorption Line and Quasar Outflow Energetics

    CERN Document Server

    Capellupo, Daniel M; Barlow, Tom A

    2014-01-01

    Broad absorption lines (BALs) in quasar spectra identify high velocity outflows that might exist in all quasars and could play a major role in feedback to galaxy evolution. The viability of BAL outflows as a feedback mechanism depends on their kinetic energies, as derived from the outflow velocities, column densities, and distances from the central quasar. We estimate these quantities for the quasar, Q1413+1143 (redshift $z_e = 2.56$), aided by the first detection of PV $\\lambda\\lambda$1118,1128 BAL variability in a quasar. In particular, PV absorption at velocities where the CIV trough does not reach zero intensity implies that the CIV BAL is saturated and the absorber only partially covers the background continuum source (with characteristic size 22.3 (cm^-2). Variability in the PV and saturated CIV BALs strongly disfavors changes in the ionization as the cause of the BAL variability, but supports models with high-column density BAL clouds moving across our lines of sight. The observed variability time of ...

  4. Spin properties of supermassive black holes with powerful outflows

    Science.gov (United States)

    Daly, Ruth. A.

    2016-05-01

    Relationships between beam power and accretion disc luminosity are studied for a sample of 55 high excitation radio galaxies (HERG), 13 low excitation radio galaxies (LERG), and 29 radio loud quasars (RLQ) with powerful outflows. The ratio of beam power to disc luminosity tends to be high for LERG, low for RLQ, and spans the full range of values for HERG. Writing general expressions for the disc luminosity and beam power and applying the empirically determined relationships allows a function that parametrizes the spins of the holes to be estimated. Interestingly, one of the solutions that is consistent with the data has a functional form that is remarkably similar to that expected in the generalized Blandford-Znajek model with a magnetic field that is similar in form to that expected in magnetically arrested disk (MAD) and advection-dominated accretion flow (ADAF) models. Values of the spin function, obtained independent of specific outflow models, suggest that spin and active galactic nucleus type are not related for these types of sources. The spin function can be used to solve for black hole spin in the context of particular outflow models, and one example is provided.

  5. How stellar feedback simultaneously regulates star formation and drives outflows

    CERN Document Server

    Hayward, Christopher C

    2015-01-01

    We present an analytic model for how momentum deposition from stellar feedback simultaneously regulates star formation and drives outflows in a turbulent interstellar medium (ISM). Because the ISM is turbulent, a given patch of ISM exhibits sub-patches with a range of surface densities. The high-density patches are 'pushed' by feedback, thereby driving turbulence and self-regulating local star formation. Sufficiently low-density patches, however, are accelerated to above the escape velocity before the region can self-adjust and are thus vented as outflows. In the turbulent-pressure-supported regime, when the gas fraction is $\\gtrsim 0.3$, the ratio of the turbulent velocity dispersion to the circular velocity is sufficiently high that at any given time, of order half of the ISM has surface density less than the critical value and thus can be blown out on a dynamical time. The resulting outflows have a mass-loading factor ($\\eta \\equiv M_{\\rm out}/M_{\\star}$) that is inversely proportional to the gas fraction ...

  6. The Launch Region of the SVS13 Outflow

    Science.gov (United States)

    Hodapp, Klaus

    2013-07-01

    We present the results of Keck Telescope laser adaptive optics integral field spectroscopy with OSIRIS of the innermost regions of the NGC1333 SVS13 jet that drives the system of Herbig-Haro objects 7-11. We find a 0.4" long micro-jet traced by the emission of shock-excited [FeII]. Beyond the extent of this jet, we find a series of near-spherical bubbles traced in the lower excitation H 2 1-0 S(1) line. While this most recent outflow activity is directed almost precisely (PA 170°) to the south of SVS13, the older bubbles show a different direction of motion and orientation more towards the south-east, connecting the recent outflow activity to the well-known, poorly collimated HH 7-11 system of Herbig-Haro objects. We postulate that the creation of a series of bubbles and the changes in outflow direction are indicative of a precessing disk. Our velocity-resolved observations of the microjet in the [FeII] emission line at 1.644μm, as well as the HI12-4 and 13-4 (Brackett series) emission lines originating from the accretion disk or jet launch region clearly show the kinematic signature of disk and jet rotation.

  7. Massive Star Formation: Characterising Infall and Outflow in dense cores.

    Science.gov (United States)

    Akhter, Shaila; Cunningham, Maria; Harvey-Smith, Lisa; Jones, Paul Andrew; Purcell, Cormac; Walsh, Andrew John

    2015-08-01

    Massive stars are some of the most important objects in the Universe, shaping the evolution of galaxies, creating chemical elements, and hence shaping the evolution of the Universe. However, the processes by which they form, and how they shape their environment during their birth processes, are not well understood. We are using NH3 data from the "The H2O Southern Galactic Plane Survey" (HOPS) to define the positions of dense cores/clumps of gas in the southern Galactic plane that are likely to form stars. Due to its effective critical density, NH3 can detect massive star forming regions effectively compared to other tracers. We did a comparative study with different methods for finding clumps and found Fellwalker as the best. We found ~ 10% of the star forming clumps with multiple components and ~ 90% clumps with single component along the line of sight. Then, using data from the "The Millimetre Astronomy Legacy Team 90 GHz" (MALT90) survey, we search for the presence of infall and outflow associated with these cores. We will subsequently use the "3D Molecular Line Radiative Transfer Code" (MOLLIE) to constrain properties of the infall and outflow, such as velocity and mass flow. The aim of the project is to determine how common infall and outflow are in star forming cores, hence providing valuable constraints on the timescales and physical process involved in massive star formation.

  8. The role of superthermal electrons in high latitude ionospheric outflows

    Science.gov (United States)

    Glocer, A.; Khazanov, G. V.; Liemohn, M. W.; Toth, G.; Gombosi, T. I.

    2014-12-01

    It is well accepted that the ionosphere is a critical source of plasma for the magnetosphere, providing O+, H+, and He+ which can have wide ranging consequences for the space environment system. Changing ion composition affects magnetic reconnection in the magnetosphere, the ring current, and the wave environment which is important for high energy radiation belt electrons. Of the myriad of mechanisms that are important in determining the ionospheric outflow solution at high latitudes, we focus on the role of superthermal electron populations. It has been demonstrated in multiple studies that even small concentrations of superthermal electrons can have a dramatic effect on the outflow solution. In this presentation, we present simulation results using our Polar Wind Outflow Model (PWOM) and our SuperThermal Electron Transport (STET) code. We describe recent results on superthermal electrons role in defining the quiet time solar wind solution with comparisons to observations. We also discuss preliminary results that combine the PWOM and STET codes for a more comprehensive treatment of the impact of superthermal electrons.

  9. On the Formation of Molecular Clumps in QSO Outflows

    CERN Document Server

    Ferrara, Andrea

    2016-01-01

    We study the origin of the cold molecular clumps in quasar outflows, recently detected in CO and HCN emission. We first describe the physical properties of such radiation-driven outflows and show that a transition from a momentum- to an energy-driven flow must occur at a radial distance of R ~ 0.25 kpc. During this transition, the shell of swept up material fragments due to Rayleigh-Taylor instabilities, but these clumps contain little mass and are likely to be rapidly ablated by the hot gas in which they are immersed. We then explore an alternative scenario in which clumps form from thermal instabilities at R >~ 1 kpc, possibly containing enough dust to catalyze molecule formation. We investigate this processes with 3D two-fluid (gas+dust) numerical simulations of a kpc^3 patch of the outflow, including atomic and dust cooling, thermal conduction, dust sputtering, and photoionization from the QSO radiation field. In all cases, dust grains are rapidly destroyed in ~10,000 years; and while some cold clumps for...

  10. Hot Jupiter Breezes: Time-dependent Outflows from Extrasolar Planets

    CERN Document Server

    Owen, James E

    2015-01-01

    We explore the dynamics of magnetically controlled outflows from Hot Jupiters, where these flows are driven by UV heating from the central star. In these systems, some of the open field lines do not allow the flow to pass smoothly through the sonic point, so that steady-state solutions do not exist in general. This paper focuses on this type of magnetic field configuration, where the resulting flow becomes manifestly time-dependent. We consider the case of both steady heating and time-variable heating, and find the time scales for the corresponding time variations of the outflow. Because the flow cannot pass through the sonic transition, it remains subsonic and leads to so-called breeze solutions. One manifestation of the time variability is that the flow samples a collection of different breeze solutions over time, and the mass outflow rate varies in quasi-periodic fashion. Because the flow is subsonic, information can propagate inward from the outer boundary, which determines, in part, the time scale of the...

  11. Hot Jupiter breezes: time-dependent outflows from extrasolar planets

    Science.gov (United States)

    Owen, James E.; Adams, Fred C.

    2016-03-01

    We explore the dynamics of magnetically controlled outflows from hot Jupiters, where these flows are driven by UV heating from the central star. In these systems, some of the open field lines do not allow the flow to pass smoothly through the sonic point, so that steady-state solutions do not exist in general. This paper focuses on this type of magnetic field configuration, where the resulting flow becomes manifestly time-dependent. We consider the case of both steady heating and time-variable heating, and find the time-scales for the corresponding time variations of the outflow. Because the flow cannot pass through the sonic transition, it remains subsonic and leads to so-called breeze solutions. One manifestation of the time variability is that the flow samples a collection of different breeze solutions over time, and the mass outflow rate varies in quasi-periodic fashion. Because the flow is subsonic, information can propagate inwards from the outer boundary, which determines, in part, the time-scale of the flow variability. This work finds the relationship between the outer boundary scale and the time-scale of flow variations. In practice, the location of the outer boundary is set by the extent of the sphere of influence of the planet. The measured time variability can be used, in principle, to constrain the parameters of the system (e.g. the strengths of the surface magnetic fields).

  12. Constraining FeLoBAL outflows from absorption line variability

    CERN Document Server

    McGraw, S M; Hamann, F W; Capellupo, D M; Gallagher, S C; Brandt, W N

    2015-01-01

    FeLoBALs are a rare class of quasar outflows with low-ionization broad absorption lines (BALs), large column densities, and potentially large kinetic energies that might be important for `feedback' to galaxy evolution. In order to probe the physical properties of these outflows, we conducted a multiple-epoch, absorption line variability study of 12 FeLoBAL quasars spanning a redshift range between 0.7 and 1.9 over rest frame time-scales of approximately 10 d to 7.6 yr. We detect absorption line variability with greater than 8 sigma confidence in 3 out of the 12 sources in our sample over time-scales of 0.6 to 7.6 yr. Variable wavelength intervals are associated with ground and excited state Fe II multiplets, the Mg II 2796, 2803 doublet, Mg I 2852, and excited state Ni II multiplets. The observed variability along with evidence of saturation in the absorption lines favors transverse motions of gas across the line of sight (LOS) as the preferred scenario, and allows us to constrain the outflow distance from th...

  13. AGN outflows trigger starbursts in gas-rich galaxies

    CERN Document Server

    Zubovas, Kastytis; King, Andrew; Wilkinson, Mark

    2013-01-01

    Recent well resolved numerical simulations of AGN feedback have shown that its effects on the host galaxy may be not only negative but also positive. In the late gas poor phase, AGN feedback blows the gas away and terminates star formation. However, in the gas-rich phase(s), AGN outflows trigger star formation by over-compressing cold dense gas and thus provide positive feedback on their hosts. In this paper we study this AGN-triggered starburst effect. We show that star formation rate in the burst increases until the star formation feedback counteracts locally the AGN outflow compression. Globally, this predicts a strong nearly linear statistical correlation between the AGN and starburst bolometric luminosities in disc galaxies, L_* \\propto L_{AGN}^{5/6}. The correlation is statistical only because AGN activity may fluctuate on short time scales (as short as tens of years), and because AGN may turn off but its effects on the host may continue to last until the AGN-driven outflow leaves the host, which may be...

  14. Serum myoglobin after cardiac catheterisation.

    OpenAIRE

    McComb, J. M.; McMaster, E A

    1982-01-01

    Study of 80 consecutive patients undergoing elective diagnostic cardiac catheterisation showed that after the procedure 25 (31%) developed myoglobinaemia. This was attributed to complications of the catheterisation in two. The remaining 23 had received premedication by intramuscular injection. In patients without intramuscular injections myoglobinaemia did not occur after uncomplicated cardiac catheterisation. The study did not support the proposition that cardiac catheterisation results in m...

  15. Hepato-cardiac disorders

    Institute of Scientific and Technical Information of China (English)

    Yasser; Mahrous; Fouad; Reem; Yehia

    2014-01-01

    Understanding the mutual relationship between the liver and the heart is important for both hepatologists and cardiologists. Hepato-cardiac diseases can be classified into heart diseases affecting the liver, liver diseases affecting the heart, and conditions affecting the heart and the liver at the same time. Differential diagnoses of liver injury are extremely important in a cardiologist’s clinical practice calling for collaboration between cardiologists and hepatologists due to the many other diseases that can affect the liver and mimic haemodynamic injury. Acute and chronic heart failure may lead to acute ischemic hepatitis or chronic congestive hepatopathy. Treatment in these cases should be directed to the primary heart disease. In patients with advanced liver disease, cirrhotic cardiomyopathy may develop including hemodynamic changes, diastolic and systolic dysfunctions, reduced cardiac performance and electrophysiological abnormalities. Cardiac evaluation is important for patients with liver diseases especially before and after liver transplantation. Liver transplantation may lead to the improvement of all cardiac changes and the reversal of cirrhotic cardiomyopathy. There are systemic diseases that may affect both the liver and the heart concomitantly including congenital, metabolic and inflammatory diseases as well as alcoholism. This review highlights these hepatocardiac diseases

  16. Primary cardiac tumors

    International Nuclear Information System (INIS)

    Cardiac tumors happen to be among the less known pathologies without clear treatment standards. Even one decade ago most of the cardiac tumor diagnosis were made post mortem, and only reports of isolated cases could be found in the literature, showing the lack of interest in the investigation of these pathologies by cardiology and cardiovascular surgery specialists. With the development of echocardiography and of cardiovascular surgery, more cases of primary and metastatic cardiac tumors have been diagnosed. Many cases have been treated by palliative or curative surgical interventions, thus increasing the reports in the world literature and the experience in this field, and pointing out the real incidence of these pathologies, not being as bizarre as it had been considered. a revision of the literature will be made, in which the frequency and the suggested interventions will be reported, as well as the cases of cardiac pathology in two cardiovascular centers of the country known by the author. The echocardiographic, pathologic and histological characteristics of the representative cases will be presented, without a greater evidence level, due to the problem's incidence and the few cases reported by these centers

  17. Cardiac MRI tagging

    International Nuclear Information System (INIS)

    Cardiac MRI tagging is an original technique based upon the perturbation of the magnetization of determined regions of the myocardium (tags). The motion of the tags accurately reflects the deformation of the underlying tissue. Data analysis requires special techniques to reconstruct the 3D motion of the heart, and to evaluate the myocardial strain, locally and throughout the whole heart. (authors)

  18. Automatic Implantable Cardiac Defibrillator

    Medline Plus

    Full Text Available ... Over the next hour you'll see the implantation of an automated implantable cardiac defibrillator. The surgery ... evening we're going to be discussing the implantation of a defibrillator. It’s a battery-powered implantable ...

  19. Cardiac effects of vasopressin.

    Science.gov (United States)

    Pelletier, Jean-Sébastien; Dicken, Bryan; Bigam, David; Cheung, Po-Yin

    2014-07-01

    Vasopressin is an essential hormone involved in the maintenance of cardiovascular homeostasis. It has been in use therapeutically for many decades, with an emphasis on its vasoconstrictive and antidiuretic properties. However, this hormone has a ubiquitous influence and has specific effects on the heart. Although difficult to separate from its powerful vascular effects in the clinical setting, a better understanding of vasopressin's direct cardiac effects could lead to its more effective clinical use for a variety of shock states by maximizing its therapeutic benefit. The cardiac-specific effects of vasopressin are complex and require further elucidation. Complicating our understanding include the various receptors and secondary messengers involved in vasopressin's effects, which may lead to various results based on differing doses and varying environmental conditions. Thus, there have been contradictory reports on vasopressin's action on the coronary vasculature and on its effect on inotropy. However, beneficial results have been found and warrant further study to expand the potential therapeutic role of vasopressin. This review outlines the effect of vasopressin on the coronary vasculature, cardiac contractility, and on hypertrophy and cardioprotection. These cardiac-specific effects of vasopressin represent an interesting area for further study for potentially important therapeutic benefits. PMID:24621650

  20. Cardiac pacemaker power sources

    International Nuclear Information System (INIS)

    A review of chemical and radioisotope batteries used in cardiac pacemakers is presented. The battery systems are examined in terms of longevity, reliability, cost, size and shape, energy density, weight, internal resistance versus time, end-of-life voltage, chemical compatibility, and potential failure mechanisms

  1. Genital tract infections and infertility.

    Science.gov (United States)

    Pellati, Donatella; Mylonakis, Ioannis; Bertoloni, Giulio; Fiore, Cristina; Andrisani, Alessandra; Ambrosini, Guido; Armanini, Decio

    2008-09-01

    Infectious agents can impair various important human functions, including reproduction. Bacteria, fungi, viruses and parasites are able to interfere with the reproductive function in both sexes. Infections of male genito-urinary tract account for about 15% of the case of male infertility. Infections can affect different sites of the male reproductive tract, such as the testis, epididymis and male accessory sex glands. Spermatozoa themselves subsequently can be affected by urogenital infections at different levels of their development, maturation and transport. Among the most common microorganisms involved in sexually transmitted infections, interfering with male fertility, there are the Chlamydia trachomatis and Neisseria gonorrhoeae. Less frequently male infertility is due to non-sexually transmitted epididymo-orchitis, mostly caused by Escherichia coli. In female, the first two microorganisms are certainly involved in cervical, tubal, and peritoneal damage, while Herpes simplex cervicitis is less dangerous. The overall importance of cervical involvement is still under discussion. Tubo-peritoneal damage seems to be the foremost manner in which microorganisms interfere with human fertility. C. trachomatis is considered the most important cause of tubal lacerations and obstruction, pelvic inflammatory disease (PID) and adhesions. N. gonorrhoeae, even though its overall incidence seems to decline, is still to be considered in the same sense, while bacterial vaginosis should not be ignored, as causative agents can produce ascending infections of the female genital tract. The role of infections, particularly co-infections, as causes of the impairment of sperm quality, motility and function needs further investigation. Tropical diseases necessitate monitoring as for their diffusion or re-diffusion in the western world. PMID:18456385

  2. The digital aqueous humor outflow meter: an alternative tool for screening of the human eye outflow facility

    OpenAIRE

    Kozobolis, Vassilios P.; Eleftherios I Paschalis; Foudoulakis, Nikitas C; et al

    2010-01-01

    Vassilios P Kozobolis, Eleftherios I Paschalis, Nikitas C Foudoulakis, Stavrenia C Koukoula, Georgios LabirisDepartment of Ophthalmology and Eye Institute of Thrace, Democritus University of Thrace, Alexandroupolis, GreecePurpose: To develop, characterize, and validate a prototype digital aqueous humor outflow tonographer (DAHOM).Material and methods: The DAHOM was developed, characterized, and validated in three phases. Phase 1 involved construction of the sensor. This was broadly based on t...

  3. Approach to urinary tract infections.

    Science.gov (United States)

    Najar, M S; Saldanha, C L; Banday, K A

    2009-10-01

    Urinary tract infection (UTI) is the most common infection experienced by humans after respiratory and gastro-intestinal infections, and also the most common cause of both community-acquired and nosocomial infections for patients admitted to hospitals. For better management and prognosis, it is mandatory to know the possible site of infection, whether the infection is uncomplicated or complicated, re-infection or relapse, or treatment failure and its pathogenesis and risk factors. Asymptomatic bacteriuria is common in certain age groups and has different connotations. It needs to be treated and completely cured in pregnant women and preschool children. Reflux nephropathy in children could result in chronic kidney disease; otherwise, urinary tract infections do not play a major role in the pathogenesis of end-stage renal disease. Symptomatic urinary tract infections occur most commonly in women of child-bearing age. Cystitis predominates, but needs to be distinguished from acute urethral syndrome that affects both sexes and has a different management plan than UTIs. The prostatitis symptoms are much more common than bacterial prostatic infections. The treatment needs to be prolonged in bacterial prostatitis and as cure rates are not very high and relapses are common, the classification of prostatitis needs to be understood. The consensus conference convened by National Institute of Health added two more groups of patients, namely, chronic prostatitis/chronic pelvic pain syndrome and asymptomatic inflammatory prostatitis, in addition to acute and chronic bacterial prostatitis. Although white blood cells in urine signify inflammation, they do not always signify UTI. Quantitative cultures of urine provide definitive evidence of UTI. Imaging studies should be done 3-6 weeks after cure of acute infection to identify abnormalities predisposing to infection or renal damage or which may affect management. Treatment of cystitis in women should be a three-day course and if

  4. Changes to the gastrointestinal tract.

    Science.gov (United States)

    2016-08-01

    This article explores changes in the ageing gastrointestinal tract, including: » Diminished sense of taste and smell. » Shrinking of the maxillary and mandibular bones in the jaw. » Slowing of oesophageal peristalsis giving a feeling that something is 'stuck in the throat'. » Relaxation of the lower sphincter leading to gastro-oesophageal reflux. » Reduction in gastric bicarbonate and prostaglandin in mucus increasing susceptibility to stomach ulcers. » Changes in villi in the small intestine reducing the area for absorption. » Overpopulation of bacteria in the small intestine leading to decreased absorption of folic acid and minerals. PMID:27573953

  5. Pharmacological characterization of the inhibition by moxonidine and agmatine on the cardioaccelerator sympathetic outflow in pithed rats.

    Science.gov (United States)

    Cobos-Puc, Luis E; Villalón, Carlos M; Ramírez-Rosas, Martha B; Sánchez-López, Araceli; Lozano-Cuenca, Jair; Gómez-Díaz, Benjamín; MaassenVanDenBrink, Antoinette; Centurión, David

    2009-08-15

    This study analysed the inhibition produced by the agonists moxonidine (imidazoline I(1) receptors>alpha(2)-adrenoceptors) and agmatine (endogenous ligand of imidazoline I(1)/I(2) receptors), using B-HT 933 (6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride; alpha(2)-adrenoceptors) for comparison, on the rat cardioaccelerator sympathetic outflow. Male Wistar rats were pithed and prepared to stimulate the cardiac sympathetic outflow or to receive i.v. bolus of exogenous noradrenaline. Sympathetic stimulation or noradrenaline produced, respectively, frequency-dependent and dose-dependent tachycardic responses. I.v. continuous infusions of moxonidine (3 and 10 microg/kg min), agmatine (1000 and 3000 microg/kg min) and B-HT 933 (30 and 100 microg/kg min) inhibited the tachycardic responses to sympathetic stimulation, but not those to noradrenaline. The cardiac sympatho-inhibition by either moxonidine (3 microg/kg min) or B-HT 933 (30 microg/kg min) was not modified by i.v. injections of saline or the antagonists AGN192403 [(+/-)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride; 3000microg/kg; imidazoline I(1) receptors] or BU224 (2-(4,5-dihydroimidazol-2-yl)quinoline hydrochloride; 300 microg/kg; imidazoline I(2) receptors) and abolished by rauwolscine (300 microg/kg; alpha(2)-adrenoceptors). At the same doses of these compounds, the sympatho-inhibition to moxonidine (10 microg/kg min) and agmatine (1000 microg/kg min) was: (1) not modified by saline, AGN192403 or BU224; (2) partially blocked by rauwolscine or the combination of rauwolscine plus BU224; and (3) abolished by the combination of rauwolscine plus AGN192403. These results demonstrate that the cardiac sympatho-inhibition to: (1) 3 microg/kg min moxonidine or 30 microg/kg min B-HT 933 involves alpha(2)-adrenoceptors; and (2) 10 microg/kg min moxonidine or 1000 microg/kg min agmatine involves alpha(2)-adrenoceptors and imidazoline I(1) receptors. PMID:19527708

  6. High-resolution mapping of the bipolar outflow in NGC 2071 - Evidence for a wind-driven molecular outflow

    International Nuclear Information System (INIS)

    The bipolar outflow in NGC 2071 has been mapped in the CS (J = 2-1), CS (J = 1-0), HCO(+) (J = 1-0), and HCN (J = 1-0) lines, using the 45-m telescope of Nobeyama Radio Observatory with the narrow beams of HPBW = 20 arcsec and 40 arcsec. It is found that the rest components of the CS (J = 2-1) and CS (J = 1-0) lines have cavities at the centers of the red and blue lobes of the CO high-velocity emission, and that a single peak of the CS spectra outside the CO red lobe splits into two peaks inside the lobe. These features of the CS emission strongly suggest that the bipolar outflow in NGC 2071 consists of two expanding dense bubbles which are driven by a stellar wind from the IR cluster. The high-resolution mapping also reveals the fact that the CS bubbles have a clumpy structure. Two of the clumps are located at the place where the shocked H2 emission was detected. This fact indicates that formation of the strong shock results from the collision between the high-velocity wind from the IR cluster and the clumps in the ambient cloud. In addition, around the IR cluster this observation shows a disklike condensation, whose size is smaller than the width of the CO high-velocity outflow. 35 refs

  7. HiRes Deconvolved Spitzer Images of 89 Protostellar Jets and Outflows: New Data on Evolution of Outflow Morphology

    CERN Document Server

    Velusamy, T; Thompson, T

    2013-01-01

    To study the role of protosellar jets and outflows in the time evolution of the parent cores and the protostars, the astronomical community needs a large enough data base of infrared images of protostars at the highest spatial resolution possible, to reveal the details of their morphology. Spitzer provides unprecedented sensitivity in the infrared to study both the jet and outflow features, however its spatial resolution is limited by its 0.85m mirror. Here we use a high resolution deconvolution algorithm, "HiRes", to improve the visualization of spatial morphology by enhancing resolution (to sub-arcsecond levels in the IRAC bands) and removing the contaminating sidelobes from bright sources in a sample of 89 protostellar objects. These reprocessed images are useful to detect: (i) wide angle outflow seen in scattered light; (ii) morphological details of H2 emission in jets and bow shocks; and (iii) compact features in MIPS 24 micron images as protostar/ disk and atomic/ionic line emissions associated with the...

  8. Cardiac surgery outcomes.

    Science.gov (United States)

    Halpin, Linda S; Barnett, Scott D; Beachy, Jim

    2003-01-01

    Accrediting organizations and payers are demanding valid and reliable data that demonstrate the value of services. Federal agencies, healthcare industry groups, and healthcare watchdog groups are increasing the demand for public access to outcomes data. A new and growing outcomes dynamic is the information requested by prospective patients in an increasingly consumer-oriented business. Patients demand outcomes, and resources are developing to meet these demands. Physicians are increasingly confronted with requests for information about their mortality and morbidity rates, malpractice suits, and disciplinary actions received. For example, in Virginia, prospective patients have access to data provided by the nonprofit group Virginia Health Information. After numerous resolutions by the Virginia Senate since 1999, the prospective Virginia medical consumer now has access to several annual publications: Virginia Hospitals: A Consumer's Guide, 1999 Annual Report and Strategic Plan Update, and the 1999 Industry Report: Virginia Hospitals and Nursing Facilities. Consumers have access to cardiac outcomes data stratified by hospital, gender, and cardiac service line (cardiac surgery, noninvasive cardiology, and invasive cardiology). This is particularly relevant to IHI because Virginia Health Information specifically targets cardiac care. IHI has a sizable investment in cardiovascular outcomes and has found outcomes measurement and research are key to providing quality care. IHI's goal is to move from an outcomes management model to a disease management model. The hope is to incorporate all aspects of the patient's continuum of care, from preoperative and diagnostic services through cardiac interventions to postoperative rehabilitation. Furthermore, every step along the way will be supported with functional status and quality of life assessments. Although these goals are ambitious and expensive, the return on investment is high. PMID:14618772

  9. Pharmacological Evidence that Histamine H3 Receptors Mediate Histamine-Induced Inhibition of the Vagal Bradycardic Out-flow in Pithed Rats.

    Science.gov (United States)

    García, Mónica; García-Pedraza, José Ángel; Villalón, Carlos M; Morán, Asunción

    2016-02-01

    In vivo stimulation of cardiac vagal neurons induces bradycardia by acetylcholine (ACh) release. As vagal release of ACh may be modulated by autoreceptors (muscarinic M2 ) and heteroreceptors (including serotonin 5-HT1 ), this study has analysed the pharmacological profile of the receptors involved in histamine-induced inhibition of the vagal bradycardic out-flow in pithed rats. For this purpose, 180 male Wistar rats were pithed, artificially ventilated and pre-treated (i.v.) with 1 mg/kg atenolol, followed by i.v. administration of physiological saline (1 ml/kg), histamine (10, 50, 100 and 200 μg/kg) or the selective histamine H1 (2-pyridylethylamine), H2 (dimaprit), H3 (methimepip) and H4 (VUF 8430) receptor agonists (1, 10, 50 and 100 μg/kg each). Under these conditions, electrical stimulation (3, 6 and 9 Hz; 15 ± 3 V and 1 ms) of the vagus nerve resulted in frequency-dependent bradycardic responses, which were (i) unchanged during the infusions of saline, 2-pyridylethylamine, dimaprit or VUF 8430; and (ii) dose-dependently inhibited by histamine or methimepip. Moreover, the inhibition of the bradycardia caused by 50 μg/kg of either histamine or methimepip (which failed to inhibit the bradycardic responses to i.v. bolus injections of acetylcholine; 1-10 μg/kg) was abolished by the H3 receptor antagonist JNJ 10181457 (1 mg/kg, i.v.). In conclusion, our results suggest that histamine-induced inhibition of the vagal bradycardic out-flow in pithed rats is mainly mediated by pre-junctional activation of histamine H3 receptors, as previously demonstrated for the vasopressor sympathetic out-flow and the vasodepressor sensory CGRPergic (calcitonin gene-related peptide) out-flow. PMID:26301462

  10. Risk factors and the effect of cardiac resynchronization therapy on cardiac and non-cardiac mortality in MADIT-CRT

    DEFF Research Database (Denmark)

    Perkiomaki, Juha S; Ruwald, Anne-Christine; Kutyifa, Valentina;

    2015-01-01

    causes, 108 (63.9%) deemed cardiac, and 61 (36.1%) non-cardiac. In multivariate analysis, increased baseline creatinine was significantly associated with both cardiac and non-cardiac deaths [hazard ratio (HR) 2.97, P ...AIMS: To understand modes of death and factors associated with the risk for cardiac and non-cardiac deaths in patients with cardiac resynchronization therapy with implantable cardioverter-defibrillator (CRT-D) vs. implantable cardioverter-defibrillator (ICD) therapy, which may help clarify...

  11. Biliary tract duplication cyst with gastric heterotopia

    International Nuclear Information System (INIS)

    Cystic duplications of the biliary tract are rare anomalies, easily mistaken for choledochal cysts. Surgical drainage is the preferred therapy for choledochal cyst, but cystic duplication necessitates surgical excision as duplications may contain heterotopic gastric mucosa leading to peptic ulceration of the biliary tract. We report a case of biliary tract duplication cyst containing heterotopic alimentary mucosa which had initially been diagnosed and surgically treated as a choledochal cyst. (orig.)

  12. Urinary tract infections and Candida albicans

    OpenAIRE

    BEHZADI, Payam; BEHZADI, Elham; Ranjbar, Reza

    2015-01-01

    Introduction Urinary tract candidiasis is known as the most frequent nosocomial fungal infection worldwide. Candida albicans is the most common cause of nosocomial fungal urinary tract infections; however, a rapid change in the distribution of Candida species is undergoing. Simultaneously, the increase of urinary tract candidiasis has led to the appearance of antifungal resistant Candida species. In this review, we have an in depth look into Candida albicans uropathogenesis and distribution o...

  13. Biliary tract duplication cyst with gastric heterotopia

    Energy Technology Data Exchange (ETDEWEB)

    Grumbach, K.; Baker, D.H.; Weigert, J.; Altman, R.P.

    1988-05-01

    Cystic duplications of the biliary tract are rare anomalies, easily mistaken for choledochal cysts. Surgical drainage is the preferred therapy for choledochal cyst, but cystic duplication necessitates surgical excision as duplications may contain heterotopic gastric mucosa leading to peptic ulceration of the biliary tract. We report a case of biliary tract duplication cyst containing heterotopic alimentary mucosa which had initially been diagnosed and surgically treated as a choledochal cyst.

  14. A statistical study of plasmaspheric plumes and ionospheric outflows observed at the dayside magnetopause

    Science.gov (United States)

    Lee, S. H.; Zhang, H.; Zong, Q.-G.; Otto, A.; Rème, H.; Liebert, E.

    2016-01-01

    We present a statistical study of plasmaspheric plumes and ionospheric outflows observed by the Cluster spacecraft near the dayside magnetopause. Plasmaspheric plumes are identified when the low-energy ions (Cluster Ion Spectrometer/Hot Ion Analyzer instrument. The ionospheric outflows are characterized by unidirectional or bidirectional field-aligned pitch angle distributions of low-energy ions observed in the dayside magnetosphere. Forty-three (10%) plasmaspheric plume events and 32 (7%) ionospheric outflow events were detected out of the 442 times that C3 crossed the dayside magnetopause between 2007 and 2009. The occurrence rate of plumes at duskside is significantly higher than that at dawnside. The occurrence rate of outflows shows a weak dawn-dusk asymmetry. We investigate the dependence of the occurrence rates of plumes and ionospheric outflows on geomagnetic activity and on solar wind/interplanetary magnetic field (IMF) conditions. The plume events tend to occur during southward IMF (duskward solar wind electric field) and moderate geomagnetic activity (Kp = 3,-30≤Dst wind electric field). The ionospheric outflows do not occur when Kp = 0, and the occurrence rate of the ionospheric outflows does not have a clear Dst dependence. Seventy-five percent (46%) of the outflows are observed in the duskside for negative (positive) IMF By. Conversely, 54% (25%) of the outflows are observed in the dawnside for positive (negative) IMF By. Finally, the occurrence rates of both plumes and outflows increase with solar wind dynamic pressure.

  15. Hypothermia ameliorates gastrointestinal ischemic injury sustained in a porcine cardiac arrest model

    Institute of Scientific and Technical Information of China (English)

    LU Yi; WANG Shuo; LI Chun-sheng

    2012-01-01

    Background During cardiac arrest,the gastrointestinal tract is sensitive to ischemia.Protection of the gastrointestinal tract is a critical factor in determining prognosis following cardiopulmonary resuscitation (CPR).This study seeks to determine the extent of gastrointestinal tract injury and the potential protective effect of inducing hypothermia following a porcine cardiac arrest model and CPR.Methods Ventricular fibrillation was induced by programmed electrical stimulation in 16 male domestic pigs (n=8 per group).Four minutes after ventricular fibrillation,CPR was performed.Pigs that successfully restored spontaneous circulation then received intravenous infusions of saline at either 4C or room temperature to produce hypothermic and control conditions respectively.Serum diamine oxidase and gastrointestinal adenosine triphosphate enzyme activity were determined and histopathology of the gastrointestinal tract was performed by light microscopy and electron microscopy.Results Significant injury of the gastrointestinal tract after CPR was found.Na+-K+ and Ca2+ adenosine triphosphate enzyme activity in the gastric tissue were significantly high in animals receiving hypothermia treatment compared to controls.Hypothermia also significantly reduced serum diamine oxidase after CPR compared to the control group.Moreover,severe injury sustained by the gastrointestinal tissue was significantly ameliorated under hypothermic conditions compared to controls.Conclusions Gastrointestinal injury and abnormal energy metabolism are strikingly evident following CPR.Hypothermia,which is induced by an infusion of 4C saline,can rapidly reduce internal body temperature,improve energy metabolism,and ameliorate injury to the gastrointestinal mucosa after CPR.

  16. Influence of vesicoureteral reflux and urinary tract infection on renal growth in children with upper urinary tract duplication

    International Nuclear Information System (INIS)

    The growth of the renal parenchyma was examined in children with duplicated outflow systems, vesicoureteral reflux (VUR), urinary tract infection (UTI) and no sign of obstruction. Ten patients with reflux occurring only in the caudal system (group A) and 4 patients with reflux both to the caudal and the apical system (group B) were studied shortly after their first UTI (study 1) and then 1.5 to 9 years later (study 2). The frequency of UTI was relatively high during the follow-up period. At urography, renal length and renal area were normal in group A in studies 1 and 2. Parenchymal thickness of the apical pole (APT/L) did not differ from normal values in any of the studies. Parenchymal thickness of the caudal pole (CPT/L) was significantly smaller than normal in both studies. There was also a significant decrease in CPT/L between study 1 and 2. UTI during the first year of life was associated with a greater reduction in CPT/L. The determination of renal length and renal area in children with a duplicated ureter, VUR and UTI, does not identify subjects at risk of developing renal growth retardation while serial determinations of parenchymal thickness appear to be an appropriate method. (orig.)

  17. Pharmacological profile of the inhibition by dihydroergotamine and methysergide on the cardioaccelerator sympathetic outflow in pithed rats.

    Science.gov (United States)

    Lozano-Cuenca, Jair; Muñoz-Islas, Enriqueta; González-Hernández, Abimael; Centurión, David; Cobos-Puc, Luis E; Sánchez-López, Araceli; Pertz, Heinz H; Villalón, Carlos M

    2009-06-10

    The present study set out to analyse the pharmacological profile of the inhibitory responses induced by the antimigraine agents dihydroergotamine (DHE) and methysergide on the tachycardic responses to preganglionic sympathetic stimulation in pithed rats. For this purpose, 132 male Wistar normotensive rats were pithed and prepared to: (i) selectively stimulate the preganglionic (C(7)-T(1)) cardiac sympathetic outflow; or (ii) receive intravenous (i.v.) bolus injections of exogenous noradrenaline. Electrical sympathetic stimulation or exogenous noradrenaline produced, respectively, frequency-dependent and dose-dependent tachycardic responses. Moreover, i.v. continuous infusions of DHE (1.8, 3.1 and 5.6 microg/kg x min) or methysergide (100, 300 and 1000 microg/kg x min) dose-dependently inhibited the tachycardic responses to sympathetic stimulation, but not those to exogenous noradrenaline. Using physiological saline or antagonists (given as i.v. bolus injections), the cardiac sympatho-inhibition induced by either DHE (3.1 microg/kg x min) or methysergide (300 microg/kg x min) was: (1) unaffected by saline (1 ml/kg); (2) partially blocked by the antagonists rauwolscine (300 microg/kg; alpha(2)) or N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl) [1,1,-biphenyl]-4-carboxamide hydrochloride monohydrate (GR127935, 300 microg/kg; 5-HT(1B/1D)); and (3) completely antagonised by the combination rauwolscine plus GR127935. These antagonists, at doses high enough to completely block their respective receptors, failed to modify the sympathetically-induced tachycardic responses per se. The above results, taken together, suggest that the cardiac sympatho-inhibition induced by DHE (3.1 microg/kg x min) and methysergide (300 microg/kg x min) may be mainly mediated by stimulation of both alpha(2)-adrenoceptors and 5-HT(1B/1D) receptors. PMID:19356724

  18. Cardiac fusion and complex congenital cardiac defects in thoracopagus twins: diagnostic value of cardiac CT

    Energy Technology Data Exchange (ETDEWEB)

    Goo, Hyun Woo [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Seoul (Korea, Republic of); Park, Jeong-Jun [University of Ulsan College of Medicine, Asan Medical Center, Department of Pediatric Cardiac Surgery, Seoul (Korea, Republic of); Kim, Ellen Ai-Rhan [University of Ulsan College of Medicine, Asan Medical Center, Division of Neonatology, Department of Pediatrics, Seoul (Korea, Republic of); Won, Hye-Sung [University of Ulsan College of Medicine, Asan Medical Center, Department of Obstetrics and Gynecology, Seoul (Korea, Republic of)

    2014-09-15

    Most thoracopagus twins present with cardiac fusion and associated congenital cardiac defects, and assessment of this anatomy is of critical importance in determining patient care and outcome. Cardiac CT with electrocardiographic triggering provides an accurate and quick morphological assessment of both intracardiac and extracardiac structures in newborns, making it the best imaging modality to assess thoracopagus twins during the neonatal period. In this case report, we highlight the diagnostic value of cardiac CT in thoracopagus twins with an interatrial channel and complex congenital cardiac defects. (orig.)

  19. Assessment of Cardiac Functions in Infants with Cow’s Milk Allergy

    OpenAIRE

    Ece, İbrahim; Demirören, Kaan; Demir, Nihat; Uner, Abdurrahman; Balli, Sevket

    2014-01-01

    Background Cow’s milk allergy is the most common food allergy in children, with rates estimated at 1.9% to 4.9%. Clinical phenotypes of cow’s milk allergy are varied and involve 1 or more target organs, with the main targets being the skin, respiratory system, and gastrointestinal tract. To date, no studies have investigated detailed cardiac function in children with cow’s milk allergy. The current study aimed to investigate cardiac function in infants with cow’s milk allergy. Material/Method...

  20. Modeling water outflow from tile-drained agricultural fields.

    Science.gov (United States)

    Kuzmanovski, Vladimir; Trajanov, Aneta; Leprince, Florence; Džeroski, Sašo; Debeljak, Marko

    2015-02-01

    The estimation of the pollution risk of surface and ground water with plant protection products applied on fields depends highly on the reliable prediction of the water outflows over (surface runoff) and through (discharge through sub-surface drainage systems) the soil. In previous studies, water movement through the soil has been simulated mainly using physically-based models. The most frequently used models for predicting soil water movement are MACRO, HYDRUS-1D/2D and Root Zone Water Quality Model. However, these models are difficult to apply to a small portion of land due to the information required about the soil and climate, which are difficult to obtain for each plot separately. In this paper, we focus on improving the performance and applicability of water outflow modeling by using a modeling approach based on machine learning techniques. It allows us to overcome the major drawbacks of physically-based models e.g., the complexity and difficulty of obtaining the information necessary for the calibration and the validation, by learning models from data collected from experimental fields that are representative for a wider area (region). We evaluate the proposed approach on data obtained from the La Jaillière experimental site, located in Western France. This experimental site represents one of the ten scenarios contained in the MACRO system. Our study focuses on two types of water outflows: discharge through sub-surface drainage systems and surface runoff. The results show that the proposed modeling approach successfully extracts knowledge from the collected data, avoiding the need to provide the information for calibration and validation of physically-based models. In addition, we compare the overall performance of the learned models with the performance of existing models MACRO and RZWQM. The comparison shows overall improvement in the prediction of discharge through sub-surface drainage systems, and partial improvement in the prediction of the surface

  1. Cardiac arrest in children

    Directory of Open Access Journals (Sweden)

    Tress Erika

    2010-01-01

    Full Text Available Major advances in the field of pediatric cardiac arrest (CA were made during the last decade, starting with the publication of pediatric Utstein guidelines, the 2005 recommendations by the International Liaison Committee on Resuscitation, and culminating in multicenter collaborations. The epidemiology and pathophysiology of in-hospital and out-of-hospital CA are now well described. Four phases of CA are described and the term "post-cardiac arrest syndrome" has been proposed, along with treatment goals for each of its four phases: immediate post-arrest, early post-arrest, intermediate and recovery phase. Hypothermia is recommended to be considered as a therapy for post-CA syndrome in comatose patients after CA, and large multicenter prospective studies are underway. We reviewed landmark articles related to pediatric CA published during the last decade. We present the current knowledge of epidemiology, pathophysiology and treatment of CA relevant to pre-hospital and acute care health practitioners.

  2. Cardiac arrest in children.

    Science.gov (United States)

    Tress, Erika E; Kochanek, Patrick M; Saladino, Richard A; Manole, Mioara D

    2010-07-01

    Major advances in the field of pediatric cardiac arrest (CA) were made during the last decade, starting with the publication of pediatric Utstein guidelines, the 2005 recommendations by the International Liaison Committee on Resuscitation, and culminating in multicenter collaborations. The epidemiology and pathophysiology of in-hospital and out-of-hospital CA are now well described. Four phases of CA are described and the term "post-cardiac arrest syndrome" has been proposed, along with treatment goals for each of its four phases: immediate post-arrest, early post-arrest, intermediate and recovery phase. Hypothermia is recommended to be considered as a therapy for post-CA syndrome in comatose patients after CA, and large multicenter prospective studies are underway. We reviewed landmark articles related to pediatric CA published during the last decade. We present the current knowledge of epidemiology, pathophysiology and treatment of CA relevant to pre-hospital and acute care health practitioners. PMID:20930971

  3. Socially differentiated cardiac rehabilitation

    DEFF Research Database (Denmark)

    Meillier, Lucette Kirsten; Nielsen, Kirsten Melgaard; Larsen, Finn Breinholt;

    2012-01-01

    recruitment and participation among low educated and socially vulnerable patients must be addressed to lower inequality in post-MI health. Our aim was to improve referral, attendance, and adherence rates among socially vulnerable patients by systematic screening and by offering a socially differentiated...... standard rehabilitation programme (SRP). If patients were identified as socially vulnerable, they were offered an extended version of the rehabilitation programme (ERP). Excluded patients were offered home visits by a cardiac nurse. Concordance principles were used in the individualised programme elements......%. Patients were equally distributed to the SRP and the ERP. No inequality was found in attendance and adherence among referred patients. Conclusions: It seems possible to overcome unequal referral, attendance, and adherence in cardiac rehabilitation by organisation of systematic screening and social...

  4. The Turbulent Origin of Outflow and Spin Misalignment in Multiple Star Systems

    CERN Document Server

    Offner, Stella S R; Lee, Katherine I; Arce, Hector G; Fielding, Drummond B

    2016-01-01

    The protostellar outflows of wide-separation forming binaries frequently appear misaligned. We use magneto-hydrodynamic simulations to investigate the alignment of protostellar spin and molecular outflows for forming binary pairs. We show that the protostellar pairs, which form from turbulent fragmentation within a single parent core, have randomly oriented angular momenta. Although the pairs migrate to closer separations, their spins remain partially misaligned. We produce $^{12}$CO(2-1) synthetic observations of the simulations and characterize the outflow orientation in the emission maps. The CO-identified outflows exhibit a similar random distribution and are also statistically consistent with the observed distribution of molecular outflows. We conclude that observed misalignment provides a clear signature of binary formation via turbulent fragmentation. The persistence of misaligned outflows and stellar spins following dynamical evolution may provide a signature of binary origins for more evolved multipl...

  5. ALMA OBSERVATIONS OF THE MASSIVE MOLECULAR OUTFLOW G331.512-0.103

    Energy Technology Data Exchange (ETDEWEB)

    Merello, Manuel; Bronfman, Leonardo; Garay, Guido; Lo, Nadia [Departamento de Astronomia, Universidad de Chile, Casilla 36-D, Santiago (Chile); Evans, Neal J. II [Department of Astronomy, University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, TX 78712-1205 (United States); Nyman, Lars-Ake; Cortes, Juan R. [Joint ALMA Observatory (JAO), Alonso de Cordova 3107, Vitacura, Santiago (Chile); Cunningham, Maria R. [School of Physics, University of New South Wales, Sydney, NSW 2052 (Australia)

    2013-09-01

    The object of this study is one of the most energetic and luminous molecular outflows known in the Galaxy, G331.512-0.103. Observations with ALMA Band 7 (350 GHz; 0.86 mm) reveal a very compact, extremely young bipolar outflow and a more symmetric outflowing shocked shell surrounding a very small region of ionized gas. The velocities of the bipolar outflow are about 70 km s{sup -1} on either side of the systemic velocity. The expansion velocity of the shocked shell is {approx}24 km s{sup -1}, implying a crossing time of about 2000 yr. Along the symmetry axis of the outflow, there is a velocity feature, which could be a molecular ''bullet'' of high-velocity dense material. The source is one of the youngest examples of massive molecular outflow found associated with a high-mass star.

  6. ALMA observations of the massive molecular outflow G331.512-0.103

    CERN Document Server

    Merello, Manuel; Garay, Guido; Lo, Nadia; Evans, Neal J; Nyman, Lars-Ake; Cortés, Juan R; Cunningham, Maria R

    2013-01-01

    The object of this study is one of the most energetic and luminous molecular outflows known in the Galaxy, G331.512-0.103. Observations with ALMA Band 7 (350 GHz; 0.86 mm) reveal a very compact, extremely young bipolar outflow and a more symmetric outflowing shocked shell surrounding a very small region of ionized gas. The velocities of the bipolar outflow are about 70 km s^{-1} on either side of the systemic velocity. The expansion velocity of the shocked shell is ~24 km s^{-1}, implying a crossing time of about 2000 yrs. Along the symmetry axis of the outflow, there is a velocity feature, which could be a molecular "bullet" of high-velocity dense material. The source is one of the youngest examples of massive molecular outflow found associated with a high-mass star.

  7. Effect of the flow composition on outflow rates from accretion discs around black holes

    CERN Document Server

    Kumar, Rajiv; Chattopadhyay, Indranil; Chakrabarti, Sandip K

    2013-01-01

    We studied the outflow behaviour from accretion discs around black holes taking into account the vertical equilibrium accretion flow model. The outflow rate is found to depend crucially on flow composition. Our approach is to study the outflow behaviour as function of inflow around black holes with an equation of state which allows flow to be thermally relativistic close to black holes and non relativistic far away from black holes. We studied shock ejection model. A pure electron positron pair flow never undergoes shock transition while presence of some baryons (common in outflows and jets) makes it possible to have standing shock waves in the flow. It can be concluded that the presence of protons is necessary for the flow to show the outflow behaviour. The outflow rate is maximum when the flow contains the proton number density which is 27% of the electron number density. We conclude that a pure electron-positron jet is unlikely to form.

  8. Cardiac metastases of osteosarcoma

    International Nuclear Information System (INIS)

    Osteosarcoma is a malignancy whose various sites of metastasis greatly modify its ultimate prognosis. We report a case of simultaneous pulmonary and cardiac metastases in a 41-year-old male patient with osteosarcoma of the tibia, presenting after more then one year of completion of adjuvant therapy with progressive dyspnea and cyanosis. Diagnosis was made on computerized tomogram and echocardiogram. The metastatic mass entirely occupying the right ventricle and the pulmonary artery proved fatal. (author)

  9. Cardiac Tissue Engineering

    OpenAIRE

    MILICA RADISIC; GORDANA VUNJAK-NOVAKOVIC

    2009-01-01

    We hypothesized that clinically sized (1-5 mm thick),compact cardiac constructs containing physiologically high density of viable cells (~108 cells/cm3) can be engineered in vitro by using biomimetic culture systems capable of providing oxygen transport and electrical stimulation, designed to mimic those in native heart. This hypothesis was tested by culturing rat heart cells on polymer scaffolds, either with perfusion of culture medium (physiologic interstitial velocity, supplementation of p...

  10. Cardiac developmental toxicity

    OpenAIRE

    Mahler, Gretchen J.; Jonathan T Butcher

    2011-01-01

    Congenital heart disease is a highly prevalent problem with mostly unknown origins. Many cases of CHD likely involve an environmental exposure coupled with genetic susceptibility, but practical and ethical considerations make nongenetic causes of CHD difficult to assess in humans. The development of the heart is highly conserved across all vertebrate species, making animal models an excellent option for screening potential cardiac teratogens. This review will discuss exposures known to cause ...

  11. Penetrating Cardiac Injuries

    OpenAIRE

    ÖZYAZICIOĞLU, Ahmet

    2002-01-01

    Objectives: To present our experience of penetrating cardiac injuries treated at Atatürk University hospital; in 17 years 38 patients were analyzed. Methods: Patients were classified into three groups: group A (stable), 12; group B (shock), 21; and group C (agonal), five. Five patients were treated by pericardial window and three by pericardiocentesis. Two patients in group C, 19 patients in group B and five patients in group A underwent median sternotomy or thoracotomy in the operating room...

  12. Infall and Outflow Activities in the Be star FY CMa

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Unusual activity of outflow mass motion connected with infall eventswas recorded for the B0.5 IVe star FY CMa in February 1987 from both archivalIUE spectrograms of circumstellar N v resonance lines and optical spectra of Hαand He Iλ5876 A emission lines which showed inverse P Cygni-type profiles. Weestimate the mass loss rate using ultraviolet Si IVresonance lines with expanding atmosphere modeling calculations, and describe how the radial pressure performs the dominant role in accelerating the stellar wind. We attempt to give a qualitativeexplanation for the activity observed for FY CMa in terms of circumstellar matterraining down to the star.

  13. Shocked molecular hydrogen in the bipolar outflow NGC 2071

    Science.gov (United States)

    Burton, Michael G.; Geballe, T. R.; Brand, P. W. J. L.

    1989-01-01

    Maps of the emission from the v = 1-0 S(1) line of molecular hydrogen in the bipolar outflow of NGC 2071 are presented. The line emission is shown to peak at six positions distributed irregularly along two lobes which are parallel to, but offset about 20 arcsec from, the lobes of the high-velocity CO-line emission. The energetics and composition of the high-velocity gas support a model in which the driving agent is a bipolar atomic wind which arises from the vicinity of the central IR sources and shocks the surrounding molecular cloud, evacuating a cavity within it.

  14. Benign cardiac tumours: cardiac CT and MRI imaging appearances

    International Nuclear Information System (INIS)

    Full text: Primary benign cardiac tumours are rarely found in clinical practice and are generally evaluated with echocardiography. However, with the increasing usage of helical multislice CT, the initial detection and evaluation of these masses may be made by the radiologist during routine daily practice for other indications. The echocardiographic, CT and cardiac MRI appearances of various benign cardiac tumours and masses are described and illustrated in this review

  15. Cardiac tissue engineering

    Directory of Open Access Journals (Sweden)

    MILICA RADISIC

    2005-03-01

    Full Text Available We hypothesized that clinically sized (1-5 mm thick,compact cardiac constructs containing physiologically high density of viable cells (~108 cells/cm3 can be engineered in vitro by using biomimetic culture systems capable of providing oxygen transport and electrical stimulation, designed to mimic those in native heart. This hypothesis was tested by culturing rat heart cells on polymer scaffolds, either with perfusion of culture medium (physiologic interstitial velocity, supplementation of perfluorocarbons, or with electrical stimulation (continuous application of biphasic pulses, 2 ms, 5 V, 1 Hz. Tissue constructs cultured without perfusion or electrical stimulation served as controls. Medium perfusion and addition of perfluorocarbons resulted in compact, thick constructs containing physiologic density of viable, electromechanically coupled cells, in contrast to control constructs which had only a ~100 mm thick peripheral region with functionally connected cells. Electrical stimulation of cultured constructs resulted in markedly improved contractile properties, increased amounts of cardiac proteins, and remarkably well developed ultrastructure (similar to that of native heart as compared to non-stimulated controls. We discuss here the state of the art of cardiac tissue engineering, in light of the biomimetic approach that reproduces in vitro some of the conditions present during normal tissue development.

  16. Contained Rupture in HeartMate II Outflow Graft Bend Relief Disconnection.

    Science.gov (United States)

    Chua, Kim Chai; Tan, Teing Ee; Lim, Chong Hee; Kerk, Ka Lee; Sivathasan, Cumaraswamy

    2016-03-01

    Thoratec recalled their HeartMate II ventricular assist device in March 2012 after some problems related to disconnection of the bend relief. Abrasion on the pump outflow graft caused by a disconnected bend relief is rare. We report the case of a 49-year-old man in whom a disconnected bend relief caused a puncture in the outflow graft, resulting in a contained hematoma, requiring outflow graft replacement. PMID:25348159

  17. Radiopharmaceuticals and the gastrointestinal tract

    Energy Technology Data Exchange (ETDEWEB)

    Frier, M. [Radiopharmacy Unit, Dept. of Medical Physics, Queens Medical Centre, Univ. Hospital Nottingham (United Kingdom); Perkins, A.C. [Radiopharmacy Unit, Dept. of Medical Physics, Queens Medical Centre, Univ. Hospital Nottingham (United Kingdom)

    1994-11-01

    A review is presented of the design of radiolabelled test meals for the evaluation of gastrointestinal function, including oesophageal transit, gastro-oesophageal reflux, gastric emptying, enterogastric reflux and transit through the whole bowel. Descriptions of different systems are presented, together with validations of the procedures used. Published methods for assessment of oesophageal transit show a marked degree of consistency, whereas gastric emptying studies employ a wide range of both liquid and solid test meals. Recommendations are made concerning the optimal system for investigation of each part of the gastrointestinal tract, but whichever system is adopted, it is important to employ some validation procedures, and to establish normal ranges in the population under study. (orig.)

  18. Kidneys and Urinary Tract (For Parents)

    Science.gov (United States)

    ... disorders. In kids, the more common problems include: Congenital problems of the urinary tract. As a fetus develops in the womb, any part of the urinary tract can grow to an abnormal size or in an abnormal shape or position. One common congenital abnormality (an abnormality that exists at birth) is ...

  19. Renal tract malformations: perspectives for nephrologists.

    NARCIS (Netherlands)

    Kerecuk, L.; Schreuder, M.F.; Woolf, A.S.

    2008-01-01

    Renal tract malformations are congenital anomalies of the kidneys and/or lower urinary tract. One challenging feature of these conditions is that they can present not only prenatally but also in childhood or adulthood. The most severe types of malformations, such as bilateral renal agenesis or dyspl

  20. Urinary tract infection in girls - aftercare

    Science.gov (United States)

    Symptoms of urinary tract infection (UTI) should begin to improve within 1 to 2 days in most girls. The advice below may not ... Elder JS. Urinary tract infections. In: Kliegman RM, Stanton BF, ... NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, ...

  1. Peptide Hormones in the Gastrointestinal Tract

    DEFF Research Database (Denmark)

    Rehfeld, Jens F.

    2015-01-01

    Gastrointestinal hormones are peptides released from endocrine cells and neurons in the digestive tract. More than 30 hormone genes are currently known to be expressed in the gastrointestinal tract, which makes the gut the largest hormone-producing organ in the body. Modern biology makes it feasi...

  2. Metastases of the digestive tract

    International Nuclear Information System (INIS)

    In addition to personal observations of 77 patients with one or more metastatic sites in the gastrointestinal tract, the authors reviewed over 1000 similar cases in the literature. The general radiologic aspects of each location (oesophagus, stomach, intestine, colon/rectum) are discussed. The pathophysiology of this type of metastasis explains the radiologic images obtained during barium transit examinations. The lymphatic type of spread observed in the oesophageal region in connection with carcinoma of the breast is the origin of stenosis of the middle third. The haematogenous type of diffusion encountered during melanomas creates intramural or intraluminal radiologic images. Two means of spread can be observed in the stomach. Haematogenous spread can result in frequently multiple and ulcerated nodular submucosal lesions from melanomas and bronchogenic carcinomas; it can also cause a more or less stenotic invasive image, especially in connection with carcinoma of the breast. Dissemination by means of the mesenteric reflections, and in particular around the gastrocolic ligament, explains the spread of a carcinoma of the transverse colon towards the stomach. The most frequent secondary sites in the gastrointestinal tract occur in the small intestine, the majority of these metastases being caused by pelvic tumours. Whether occurring in the small intestine or the colon, the patophysiology is similar: direct invasion by a non-contiguous primary carcinoma along the fascias and mesenteric attachments (more rarely by lymphatic permeation), dissemination by the peritoneal fluid or haematogenuous spread. In the first two types of dissemination cited, the image encountered is often hard to differentiate from radiation-induced lesions. (orig.)

  3. Pharmacological evidence that alpha2A- and alpha2C-adrenoceptors mediate the inhibition of cardioaccelerator sympathetic outflow in pithed rats.

    Science.gov (United States)

    Cobos-Puc, Luis E; Villalón, Carlos M; Sánchez-López, Araceli; Lozano-Cuenca, Jair; Pertz, Heinz H; Görnemann, Tilo; Centurión, David

    2007-01-12

    It has been suggested that the alpha(2)-adrenoceptors mediating cardiac sympatho-inhibition in pithed rats closely resemble the pharmacological profile of the alpha(2A)-adrenoceptor subtype. However, several lines of evidence suggest that more than one subtype may be involved. Thus, the present study has pharmacologically re-evaluated the receptor subtype(s) involved in the inhibitory effect of the alpha(2)-adrenoceptor agonist, B-HT 933, on the tachycardic responses elicited by selective cardiac sympathetic stimulation (0.03, 0.1, 0.3, 1 and 3 Hz) in desipramine-pretreated pithed rats. I.v. continuous infusions of B-HT 933 (30 microg/kg min), which failed to modify the tachycardic responses to exogenous noradrenaline, inhibited those induced by preganglionic (C(7)-T(1)) stimulation of the cardiac sympathetic outflow at all frequencies of stimulation (0.03-3 Hz). This cardiac sympatho-inhibitory response to B-HT 933 was: (1) unaltered by saline (1 ml/kg) or the antagonists BRL44408 (100 microg/kg; alpha(2A)) or imiloxan (3000 and 10,000 microg/kg; alpha(2B)); (2) partially antagonized by BRL44408 (300 microg/kg) or MK912 (10 microg/kg; alpha(2C)) given separately; and (3) completely antagonized by rauwolscine (300 microg/kg; alpha(2)), MK912 (30 microg/kg) or the combination of BRL44408 (300 microg/kg) plus MK912 (10 microg/kg). Moreover, the above doses of antagonists, which are high enough to block their respective receptors, failed to block per se the tachycardic responses to sympathetic stimulation. These results suggest that the cardiac sympatho-inhibition induced by B-HT 933 in pithed rats is mainly mediated by stimulation of alpha(2A)- and alpha(2C)-adrenoceptors. PMID:17109851

  4. On the thermal line emission from the outflows in ultraluminous X-ray sources

    CERN Document Server

    Xu, Ya-Di

    2016-01-01

    The atomic features in the X-ray spectra of the ultraluminous X-ray source (ULX) may be associated with the outflow (Middleton et al. 2015), which may provide a way to explore the physics of the ULXs. We construct a conical outflow model, and calculate the thermal X-ray Fe emission lines from the outflows. Our results show that thermal line luminosity decreases with increasing outflow velocity or/and opening angle of the outflow for a fixed kinetic power of the outflows. Assuming the kinetic power of the outflows to be comparable with the accretion power in the ULXs, we find that the equivalent width can be several eV for the thermal X-ray Fe emission line from the outflows in the ULXs with stellar mass black holes. The thermal line luminosity is proportional to 1/M (M is the black hole mass of the ULX). The equivalent width decreases with the black hole mass, which implies that the Fe line emission from the outflows can hardly be detected if the ULXs contain intermediate mass black holes. Our results suggest...

  5. AGN-driven outflows without quenching in simulations of high-redshift disk galaxies

    CERN Document Server

    Gabor, Jared M

    2014-01-01

    Recent observations have revealed nuclear outflows in high-redshift, star forming galaxies. We study outflows driven by Active Galactic Nuclei (AGNs) using high- resolution simulations of idealized z=2 isolated disk galaxies. Episodic accretion events lead to outflows with velocities >1000 km/s and mass outflow rates up to the star formation rate (several tens of Msun/yr). Outflowing winds escape perpendicular to the disk with wide opening angles, and are typically asymmetric (i.e. unipolar) because dense gas above or below the AGN in the resolved disk inhibits outflow. Owing to rapid variability in the accretion rates, outflowing gas may be detectable even when the AGN is effectively "off." The highest velocity outflows are concentrated within 2-3 kpc of the galactic center during the peak accretion. With our purely thermal AGN feedback model -- standard in previous literature -- the outflowing material is mostly hot (10^6 K) and diffuse (nH<10^(-2) cm-3), but includes a cold component entrained in the ho...

  6. Smoothed particle magnetohydrodynamic simulations of protostellar outflows with misaligned magnetic field and rotation axes

    CERN Document Server

    Lewis, Benjamin T; Price, Daniel J

    2015-01-01

    We have developed a modified form of the equations of smoothed particle magnetohydrodynamics which are stable in the presence of very steep density gradients. Using this formalism, we have performed simulations of the collapse of magnetised molecular cloud cores to form protostars and drive outflows. Our stable formalism allows for smaller sink particles ( 30{\\deg}, and a collimated outflow is not sustained when {\\theta} > 10{\\deg}. No substantial outflows of any kind are produced when {\\theta} > 60{\\deg}. This may place constraints on the geometry of the magnetic field in molecular clouds where bipolar outflows are seen.

  7. Indeterminacy of Spatiotemporal Cardiac Alternans

    CERN Document Server

    Zhao, Xiaopeng

    2007-01-01

    Cardiac alternans, a beat-to-beat alternation in action potential duration (at the cellular level) or in ECG morphology (at the whole heart level), is a marker of ventricular fibrillation, a fatal heart rhythm that kills hundreds of thousands of people in the US each year. Investigating cardiac alternans may lead to a better understanding of the mechanisms of cardiac arrhythmias and eventually better algorithms for the prediction and prevention of such dreadful diseases. In paced cardiac tissue, alternans develops under increasingly shorter pacing period. Existing experimental and theoretical studies adopt the assumption that alternans in homogeneous cardiac tissue is exclusively determined by the pacing period. In contrast, we find that, when calcium-driven alternans develops in cardiac fibers, it may take different spatiotemporal patterns depending on the pacing history. Because there coexist multiple alternans solutions for a given pacing period, the alternans pattern on a fiber becomes unpredictable. Usin...

  8. Biosynthesis of cardiac natriuretic peptides

    DEFF Research Database (Denmark)

    Goetze, Jens Peter

    2010-01-01

    Cardiac-derived peptide hormones were identified more than 25 years ago. An astonishing amount of clinical studies have established cardiac natriuretic peptides and their molecular precursors as useful markers of heart disease. In contrast to the clinical applications, the biogenesis of cardiac p...... competent endocrine cells. The structurally related atrial natriuretic peptide will be mentioned where appropriate, whereas C-type natriuretic peptide will not be considered as a cardiac peptide of relevance in mammalian physiology....... characterized. An ongoing characterization of the molecular heterogeneity will help appreciate the biosynthetic capacity of the endocrine heart and could introduce new diagnostic possibilities. Notably, different biosynthetic products may not be equal markers of the same pathophysiological processes. An...... inefficient post-translational prohormone maturation will also affect the biology of the cardiac natriuretic peptide system. This review aims at summarizing the myocardial synthesis of natriuretic peptides focusing on B-type natriuretic peptide, where new data has disclosed cardiac myocytes as highly...

  9. Biosynthesis of cardiac natriuretic peptides

    DEFF Research Database (Denmark)

    Goetze, Jens Peter

    2010-01-01

    Cardiac-derived peptide hormones were identified more than 25 years ago. An astonishing amount of clinical studies have established cardiac natriuretic peptides and their molecular precursors as useful markers of heart disease. In contrast to the clinical applications, the biogenesis of cardiac...... inefficient post-translational prohormone maturation will also affect the biology of the cardiac natriuretic peptide system. This review aims at summarizing the myocardial synthesis of natriuretic peptides focusing on B-type natriuretic peptide, where new data has disclosed cardiac myocytes as highly...... competent endocrine cells. The structurally related atrial natriuretic peptide will be mentioned where appropriate, whereas C-type natriuretic peptide will not be considered as a cardiac peptide of relevance in mammalian physiology....

  10. An overview of cardiac morphogenesis.

    Science.gov (United States)

    Schleich, Jean-Marc; Abdulla, Tariq; Summers, Ron; Houyel, Lucile

    2013-11-01

    Accurate knowledge of normal cardiac development is essential for properly understanding the morphogenesis of congenital cardiac malformations that represent the most common congenital anomaly in newborns. The heart is the first organ to function during embryonic development and is fully formed at 8 weeks of gestation. Recent studies stemming from molecular genetics have allowed specification of the role of cellular precursors in the field of heart development. In this article we review the different steps of heart development, focusing on the processes of alignment and septation. We also show, as often as possible, the links between abnormalities of cardiac development and the main congenital heart defects. The development of animal models has permitted the unraveling of many mechanisms that potentially lead to cardiac malformations. A next step towards a better knowledge of cardiac development could be multiscale cardiac modelling. PMID:24138816

  11. The digital aqueous humor outflow meter: an alternative tool for screening of the human eye outflow facility

    Directory of Open Access Journals (Sweden)

    Vassilios P Kozobolis

    2010-08-01

    Full Text Available Vassilios P Kozobolis, Eleftherios I Paschalis, Nikitas C Foudoulakis, Stavrenia C Koukoula, Georgios LabirisDepartment of Ophthalmology and Eye Institute of Thrace, Democritus University of Thrace, Alexandroupolis, GreecePurpose: To develop, characterize, and validate a prototype digital aqueous humor outflow tonographer (DAHOM.Material and methods: The DAHOM was developed, characterized, and validated in three phases. Phase 1 involved construction of the sensor. This was broadly based on the fundamental design of a typical Schiotz tonographer with a series of improvements, including corneal indentation, which was converted to an electrical signal via a linear variable differential transducer, an analog signal which was converted to digital via ADC circuitry, and digital data acquisition and processing which was made possible by a serial port interface. Phase 2 comprised development of software for automated assessment of the outflow facility. Automated outflow facility assessment incorporated a series of fundamental improvements in comparison with traditional techniques, including software-based filtering of ripple noise and extreme variations, rigidity impact analysis, and evaluation of the impact of patient age, central corneal thickness, and ocular axial length. Phase 3 comprised characterization and validation of DAHOM, for which we developed an experimental setup using porcine cadaver eyes. DAHOM’s repeatability was evaluated by means of Cronbach’s alpha and intraclass correlation coefficient. The level of agreement with a standard Schiotz tonographer was evaluated by means of paired t-tests and Bland-Altman analysis in human eyes.Results: The experimental setup provided the necessary data for the characterization of DAHOM. A fourth order polynomial equation provided excellent fit (R square >0.999. DAHOM demonstrated high repeatability (Cronbach’s alpha ≥0.997; intraclass correlation coefficient ≥0.987 and an adequate level of

  12. Sudden Cardiac Death in Athletes.

    Science.gov (United States)

    Wasfy, Meagan M; Hutter, Adolph M; Weiner, Rory B

    2016-01-01

    There are clear health benefits to exercise; even so, patients with cardiac conditions who engage in exercise and athletic competition may on rare occasion experience sudden cardiac death (SCD). This article reviews the epidemiology and common causes of SCD in specific athlete populations. There is ongoing debate about the optimal mechanism for SCD prevention, specifically regarding the inclusion of the ECG and/or cardiac imaging in routine preparticipation sports evaluation. This controversy and contemporary screening recommendations are also reviewed. PMID:27486488

  13. Cardiac Rehabilitation: Guidelines and Recommendations

    OpenAIRE

    Catherine Monpere

    1998-01-01

    Cardiac rehabilitation has been shown to improve exercise tolerance and symptomatology in patients experiencing angina or heart failure and reduce long term mortality after myocardial infarction, with a good cost-effectiveness ratio. In addition to these `hard' endpoints, cardiac rehabilitation improves the patient's quality of life and risk factor profile through a multifactorial intervention. Indeed, cardiac rehabilitation is no longer restricted to physical reconditioning, but should now b...

  14. The Prevalence of Gas Outflows in Type 2 AGNs

    CERN Document Server

    Woo, Jong-Hak; Son, Donghoon; Karouzos, Marios

    2015-01-01

    To constrain the nature and fraction of the ionized gas outflows in AGNs, we perform a detailed analysis on gas kinematics as manifested by the velocity dispersion and shift of the OIII {\\lambda}5007 emission line, using a large sample of ~39,000 type 2 AGNs at z<0.3. First, we confirm a broad correlation between OIII and stellar velocity dispersions, indicating that the bulge gravitational potential plays a main role in determining the OIII kinematics. However, OIII velocity dispersion is on average larger than stellar velocity dispersion by a factor of 1.3-1.4, suggesting that the non-gravitational component, i.e., outflows, is almost comparable to the gravitational component. Second, the increase of the OIII velocity dispersion (after normalized by stellar velocity dispersion) with both AGN luminosity and Eddington ratio suggests that non-gravitational kinematics are clearly linked to AGN accretion. The distribution in the OIII velocity - velocity dispersion diagram dramatically expands toward large val...

  15. Far-IR Excited OH Lines from Orion KL Outflows

    CERN Document Server

    Goicoechea, J R; Cernicharo, J; Daniel, F; Lerate, M R; Lim, T L; Swinyard, B M; Viti, S; Yates, J; Barlow, Michael J.; Cernicharo, Jose; Daniel, Fabien; Goicoechea, Javier R.; Lerate, Mercedes R.; Lim, Tanya L.; Swinyard, Bruce M.; Viti, Serena; Yates, Jeremy

    2006-01-01

    As part of the first far-IR line survey towards Orion KL, we present the detection of seven new rotationally excited OH Lambda-doublets (at 48, 65, 71, 79, 98 and 115 um). Observations were performed with the Long Wavelength Spectrometer (LWS) Fabry-Perots on board the Infrared Space Observatory (ISO). In total, more than 20 resolved OH rotational lines, with upper energy levels up to 620 K, have been detected at an angular and velocity resolutions of 80$'' and 33 km s^-1 respectively. OH line profiles show a complex behavior evolving from pure absorption, P-Cygni type to pure emission. We also present a large scale 6' declination raster in the OH ^2\\Pi_3/2 J=5/2^+-3/2^- and ^2\\Pi_3/2 J=7/2^-5/2^+ lines (at 119.441 and 84.597 um) revealing the decrease of excitation outside the core of the cloud. From the observed profiles, mean intrinsic line widths and velocity offsets between emission and absorption line peaks we conclude that most of the excited OH arises from Orion outflow(s), i.e. the ``plateau'' compon...

  16. Condensation of MgS in outflows from carbon stars

    CERN Document Server

    Zhukovska, Svitlana

    2008-01-01

    The basic mechanism responsible for the widespread condensation of MgS in the outflows from carbon rich stars on the tip of the AGB is discussed with the aim of developing a condensation model that can be applied in model calculations of dust formation in stellar winds. The different possibilities how MgS may be formed in the chemical environment of outflows from carbon stars are explored by some thermochemical calculations and by a detailed analysis of the growth kinetics of grains in stellar winds. The optical properties of core-mantle grains with a MgS mantle are calculated to demonstrate that such grains reproduce the structure of the observed 30 $\\mu$m feature. These considerations are complemented by model calculations of circumstellar dust shells around carbon stars. It is argued that MgS is formed via precipitation on silicon carbide grains. This formation mechanism explains some of the basic observed features of MgS condensation in dust shells around carbon stars. A weak secondary peak at about 33 .....

  17. Disc outflows and high-luminosity true type 2 AGN

    Science.gov (United States)

    Elitzur, Moshe; Netzer, Hagai

    2016-06-01

    The absence of intrinsic broad-line emission has been reported in a number of active galactic nuclei (AGN), including some with high Eddington ratios. Such `true type 2 AGN' are inherent to the disc-wind scenario for the broad-line region: broad-line emission requires a minimal column density, implying a minimal outflow rate and thus a minimal accretion rate. Here we perform a detailed analysis of the consequences of mass conservation in the process of accretion through a central disc. The resulting constraints on luminosity are consistent with all the cases where claimed detections of true type 2 AGN pass stringent criteria, and predict that intrinsic broad-line emission can disappear at luminosities as high as ˜4 × 1046 erg s-1 and any Eddington ratio, though more detections can be expected at Eddington ratios below ˜1 per cent. Our results are applicable to every disc outflow model, whatever its details and whether clumpy or smooth, irrespective of the wind structure and its underlying dynamics. While other factors, such as changes in spectral energy distribution or covering factor, can affect the intensities of broad emission lines, within this scenario they can only produce true type 2 AGN of higher luminosity then those prescribed by mass conservation.

  18. Strong Gravitational Lensing and the Structure of Quasar Outflows

    CERN Document Server

    Chelouche, D

    2003-01-01

    We show that by analyzing the spectra of lensed broad absorption line quasars (BALQSOs), it is possible to reveal key properties of the outflowing gas in the inner regions of these objects. This results from the fact that each image of the quasar corresponds to a different line of sight through the outflow. This combined with dynamical estimates for the location of the flow, adds new information concerning the lateral, non line of sight structure of the absorbing gas. Here we consider a sample of lensed BALQSOs and note that the similarity of BAL profiles of different images of the same quasar implies that the flow is relatively isotropic on small scales. We show that its geometry is inconsistent with the ballistically accelerated spherical cloud model, and that wind models provide a better description of the flow structure. Furthermore, observations seem to disagree with naive interpretations of recent time-dependent wind simulations. This may hint on several important physical processes that govern the stru...

  19. Disk Outflows and High-Luminosity True Type 2 AGN

    CERN Document Server

    Elitzur, Moshe

    2016-01-01

    The absence of intrinsic broad line emission has been reported in a number of active galactic nuclei (AGN), including some with high Eddington ratios. Such "true type 2 AGN" are inherent to the disk-wind scenario for the broad line region: Broad line emission requires a minimal column density, implying a minimal outflow rate and thus a minimal accretion rate. Here we perform a detailed analysis of the consequences of mass conservation in the process of accretion through a central disk. The resulting constraints on luminosity are consistent with all the cases where claimed detections of true type 2 AGN pass stringent criteria, and predict that intrinsic broad line emission can disappear at luminosities as high as about 4x$10^{46}$ erg s$^{-1}$ and any Eddington ratio, though more detections can be expected at Eddington ratios below about 1%. Our results are applicable to every disk outflow model, whatever its details and whether clumpy or smooth, irrespective of the wind structure and its underlying dynamics. ...

  20. Outflows and complex stellar kinematics in SDSS star forming galaxies

    CERN Document Server

    Cicone, Claudia; Marconi, Alessandro

    2016-01-01

    We investigate the properties of star formation-driven outflows by using a large spectroscopic sample of ~160,000 local "normal" star forming galaxies, drawn from the SDSS, spanning a wide range of star formation rates and stellar masses. The galaxy sample is divided into a fine grid of bins in the M_*-SFR parameter space, for each of which we produce a composite spectrum by stacking together the SDSS spectra of the galaxies contained in that bin. We exploit the high signal-to-noise of the stacked spectra to study the emergence of faint features of optical emission lines that may trace galactic outflows and would otherwise be too faint to detect in individual galaxy spectra. We adopt a novel approach that relies on the comparison between the line-of-sight velocity distribution (LoSVD) of the ionised gas (as traced by the [OIII]5007 and Halpha+[NII]6548,6583 emission lines) and the LoSVD of the stars, which are used as a reference tracing virial motions. Significant deviations of the gas kinematics from the st...

  1. Geological behavior of wet outflow deposition fly ash

    Institute of Scientific and Technical Information of China (English)

    周德泉; 赵明华; 刘宏利; 周毅; 严聪

    2008-01-01

    The geological behaviors of wet outflow deposition fly ash were investigated, including the feature of in-situ single and even bridge cone penetration test (CPT) curves, the change of the penetration parameters and vane strength with the increase of depth and the difference of the penetration resistance on and down the water level. Drilling, CPT and vane shear test were carried out in silty clay, fine sand, and fly ash of the ash-dam. The CPT curves of the fly ash do not show a critical depth. The cone resistance (qc) of the fly ash is smaller than that of silty clay or sand; the friction resistance is smaller than that of filling silty clay, similar to that of deposition silty clay or more than that of fine sand; the friction ratio is smaller than that of filling silty clay, or more than that of deposition silty clay or much more than that of fine sand. The specific penetration resistance (ps) is similar to that of filling silty clay, or more than that of deposition silty clay. There is a clear interface effect between the deposition fly ash and the clay. Interface effect of ps-h curve at the groundwater table is clear, and ps of the fly ash reduces significantly under the table. The vane strength of the fly ash increases as the depth increases. The deposition fly ash with wet outflow is similar to silt in the geological behavior.

  2. The Launch Region of the SVS 13 Outflow and Jet

    CERN Document Server

    Hodapp, Klaus W

    2014-01-01

    We present the results of Keck Telescope laser adaptive optics integral field spectroscopy with OSIRIS of the innermost regions of the NGC 1333 SVS 13 outflow that forms the system of Herbig-Haro objects 7-11. We find a bright 0.2 arc sec long microjet traced by the emission of shock-excited [FeII]. Beyond the extent of this jet, we find a series of bubbles and fragments of bubbles that are traced in the lower excitation H_2 1-0 S(1) line. While the most recent outflow activity is directed almost precisely (PA ~145 deg) to the south-east of SVS 13, there is clear indication that prior bubble ejections were pointed in different directions. Within these variations, a clear connection of the newly observed bubble ejection events to the well-known, poorly collimated HH 7-11 system of Herbig-Haro objects is established. Astrometry of the youngest of the expanding shock fronts at 3 epochs covering a time span of over two years gives kinematic ages for two of these. The kinematic age of the youngest bubble is slight...

  3. Ultrafast Outflows: Galaxy-scale Active Galactic Nucleus Feedback

    Science.gov (United States)

    Wagner, A. Y.; Umemura, M.; Bicknell, G. V.

    2013-01-01

    We show, using global three-dimensional grid-based hydrodynamical simulations, that ultrafast outflows (UFOs) from active galactic nuclei (AGNs) result in considerable feedback of energy and momentum into the interstellar medium (ISM) of the host galaxy. The AGN wind interacts strongly with the inhomogeneous, two-phase ISM consisting of dense clouds embedded in a tenuous, hot, hydrostatic medium. The outflow floods through the intercloud channels, sweeps up the hot ISM, and ablates and disperses the dense clouds. The momentum of the UFO is primarily transferred to the dense clouds via the ram pressure in the channel flow, and the wind-blown bubble evolves in the energy-driven regime. Any dependence on UFO opening angle disappears after the first interaction with obstructing clouds. On kpc scales, therefore, feedback by UFOs operates similarly to feedback by relativistic AGN jets. Negative feedback is significantly stronger if clouds are distributed spherically rather than in a disk. In the latter case, the turbulent backflow of the wind drives mass inflow toward the central black hole. Considering the common occurrence of UFOs in AGNs, they are likely to be important in the cosmological feedback cycles of galaxy formation.

  4. Ultra Fast Outflows: Galaxy-Scale Active Galactic Nucleus Feedback

    CERN Document Server

    Wagner, A Y; Bicknell, G V

    2012-01-01

    We show, using global 3D grid-based hydrodynamical simulations, that Ultra Fast Outflows (UFOs) from Active Galactic Nuclei (AGN) result in considerable feedback of energy and momentum into the interstellar medium (ISM) of the host galaxy. The AGN wind interacts strongly with the inhomogeneous, two-phase ISM consisting of dense clouds embedded in a tenuous hot hydrostatic medium. The outflow floods through the inter-cloud channels, sweeps up the hot ISM, and ablates and disperses the dense clouds. The momentum of the UFO is primarily transferred to the dense clouds via the ram pressure in the channel flow, and the wind-blown bubble evolves in the energy-driven regime. Any dependence on UFO opening angle disappears after the first interaction with obstructing clouds. On kpc scales, therefore, feedback by UFOs operates similarly to feedback by relativistic AGN jets. Negative feedback is significantly stronger if clouds are distributed spherically, rather than in a disc. In the latter case the turbulent backflow...

  5. ULTRAFAST OUTFLOWS: GALAXY-SCALE ACTIVE GALACTIC NUCLEUS FEEDBACK

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, A. Y.; Umemura, M. [Center for Computational Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577 (Japan); Bicknell, G. V., E-mail: ayw@ccs.tsukuba.ac.jp [Research School of Astronomy and Astrophysics, Australian National University, ACT 2611 (Australia)

    2013-01-20

    We show, using global three-dimensional grid-based hydrodynamical simulations, that ultrafast outflows (UFOs) from active galactic nuclei (AGNs) result in considerable feedback of energy and momentum into the interstellar medium (ISM) of the host galaxy. The AGN wind interacts strongly with the inhomogeneous, two-phase ISM consisting of dense clouds embedded in a tenuous, hot, hydrostatic medium. The outflow floods through the intercloud channels, sweeps up the hot ISM, and ablates and disperses the dense clouds. The momentum of the UFO is primarily transferred to the dense clouds via the ram pressure in the channel flow, and the wind-blown bubble evolves in the energy-driven regime. Any dependence on UFO opening angle disappears after the first interaction with obstructing clouds. On kpc scales, therefore, feedback by UFOs operates similarly to feedback by relativistic AGN jets. Negative feedback is significantly stronger if clouds are distributed spherically rather than in a disk. In the latter case, the turbulent backflow of the wind drives mass inflow toward the central black hole. Considering the common occurrence of UFOs in AGNs, they are likely to be important in the cosmological feedback cycles of galaxy formation.

  6. A Two-Temperature Model of Magnetized Protostellar Outflows

    CERN Document Server

    Wang, Liang-Yao; Krasnopolsky, Ruben; Chiang, Tzu-Yang

    2015-01-01

    We explore kinematics and morphologies of molecular outflows driven by young protostars using magnetohydrodynamic simulations in the context of the unified wind model of Shang et al. The model explains the observed high-velocity jet and low-velocity shell features. In this work we investigate how these characteristics are affected by the underlying temperature and magnetic field strength. We study the problem of a warm wind running into a cold ambient toroid by using a tracer field that keeps track of the wind material. While an isothermal equation of state is adopted, the effective temperature is determined locally based on the wind mass fraction. In the unified wind model, the density of the wind is cylindrically stratified and highly concentrated toward the outflow axis. Our simulations show that for a sufficiently magnetized wind, the jet identity can be well maintained even at high temperatures. However, for a high temperature wind with low magnetization, the thermal pressure of the wind gas can drive ma...

  7. Glider observations of the Dotson Ice Shelf outflow

    Science.gov (United States)

    Miles, Travis; Lee, Sang Hoon; Wåhlin, Anna; Ha, Ho Kyung; Kim, Tae Wan; Assmann, Karen M.; Schofield, Oscar

    2016-01-01

    The Amundsen Sea is one of the most productive polynyas in the Antarctic per unit area and is undergoing rapid changes including a reduction in sea ice duration, thinning ice sheets, retreat of glaciers and the potential collapse of the Thwaites Glacier in Pine Island Bay. A growing body of research has indicated that these changes are altering the water mass properties and associated biogeochemistry within the polynya. Unfortunately difficulties in accessing the remote location have greatly limited the amount of in situ data that has been collected. In this study data from a Teledyne-Webb Slocum glider was used to supplement ship-based sampling along the Dotson Ice Shelf (DIS). This autonomous underwater vehicle revealed a detailed view of a meltwater laden outflow from below the western flank of the DIS. Circumpolar Deep Water intruding onto the shelf drives glacial melt and the supply of macronutrients that, along with ample light, supports the large phytoplankton blooms in the Amundsen Sea Polynya. Less well understood is the source of micronutrients, such as iron, necessary to support this bloom to the central polynya where chlorophyll concentrations are highest. This outflow region showed decreasing optical backscatter with proximity to the bed indicating that particulate matter was sourced from the overlying glacier rather than resuspended sediment. This result suggests that particulate iron, and potentially phytoplankton primary productivity, is intrinsically linked to the magnitude and duration of sub-glacial melt from Circumpolar Deep Water intrusions onto the shelf.

  8. Multiple Outflows in the Giant Eruption of a Massive Star

    CERN Document Server

    Humphreys, Roberta M; Gordon, Michael S; Jones, Terry J

    2016-01-01

    The supernova impostor PSN J09132750+7627410 in NGC 2748 reached a maximum luminosity of approximately -14 mag. It was quickly realized that its was not a true supernova, but another example of a non-terminal giant eruption. PSN J09132750+7627410 is distinguished by multiple P Cygni absorption minima in the Balmer emission lines that correspond to outflow velocities of -400, -1100, and -1600 km/s. Multiple outflows have been observed in only a few other objects. In this paper we describe the evolution of the spectrum and the P Cygni profiles for three months past maximum, the post-maximum formation of a cool, dense wind, and the identification of a possible progenitor. One of the possible progenitors is an infrared source. Its pre-eruption spectral energy distribution suggests a bolometric luminosity of -8.3 mag and a dust temperature of 780 degrees K. If it is the progenitor it is above the AGB limit unlike the intermediate luminosity red transients. The three P Cygni profiles could be due to ejecta from the...

  9. NIHAO XI: Formation of Ultra-Diffuse Galaxies by outflows

    CERN Document Server

    Di Cintio, Arianna; Dutton, Aaron A; Macciò, Andrea V; Obreja, Aura C; Dekel, Avishai

    2016-01-01

    We address the origin of Ultra-Diffuse Galaxies (UDGs), which have stellar masses typical of dwarf galaxies but effective radii of Milky Way-sized objects. Their formation mechanism, and whether they are failed $\\rm L_{\\star}$ galaxies or diffuse dwarfs, are challenging issues. Using zoom-in cosmological simulations from the NIHAO project, we show that UDG analogues form naturally in medium-mass haloes due to episodes of gas outflows associated with star formation. The simulated UDGs live in isolated haloes of masses $10^{10-11}\\rm M_{\\odot}$, have stellar masses of $10^{7-8.5}\\rm M_{\\odot}$, effective radii larger than 1 kpc and dark matter cores. They show a broad range of colors, an average S\\'ersic index of 0.83, a typical distribution of halo spin and concentration, and a non-negligible HI gas mass of $10^{7-9}\\rm M_{\\odot}$, which correlates with the extent of the galaxy. Gas availability is crucial to the internal processes that form UDGs: feedback driven gas outflows, and subsequent dark matter and st...

  10. Stellar Feedback: A Multiphase Interstellar Medium and Galactic Outflows

    Science.gov (United States)

    Ceverino, D.

    2009-12-01

    I am presenting new results in our ongoing effort of improving the theory of galaxy formation in a ΛCDM Universe. I pay a special attention to the role of supernova explosions and stellar winds in the galaxy assembly. These processes happen at very small scales, they affect the interstellar medium (ISM) at galactic scales and regulate the formation of a whole galaxy. Previous attempts of mimicking these effects in simulations of galaxy formation use very simplified assumptions. I develop a much more realistic prescription for modeling the feedback, which minimizes any ad hoc sub-grid physics. I start with developing high resolution models of the ISM and formulate the conditions required for its realistic functionality: formation of multi-phase medium with hot chimneys, super-bubbles, cold molecular phase, and very slow consumption of gas. Once these effects are resolved in cosmological simulations, galaxy formation proceeds more realistically. For example, I do not have the overcooling problem. The angular momentum problem (resulting in a too massive bulge) is also reduced substantially: the rotation curves are nearly flat. The galaxy formation also becomes more violent. At high redshift, I routinely find substantial gas outflows from star-forming galaxies. I describe several scaling relations between outflow properties and galaxy properties: maximum velocity, mass and kinetic energy versus stellar mass and SFR. The simulations reproduce this picture only if the resolution is very high: better than 70 pc.

  11. HNCO enhancement by shocks in the L1157 molecular outflow

    CERN Document Server

    Rodriguez-Fernandez, Nemesio; Gueth, Frederic; Bachiller, Rafael

    2010-01-01

    The isocyanic acid (HNCO) presents an extended distribution in the centers of the Milky Way and the spiral galaxy IC342. Based on the morphology of the emission and the HNCO abundance with respect to H2, several authors made the hypothesis that HNCO could be a good tracer of interstellar shocks. Here we test this hypothesis by observing a well-known Galactic source where the chemistry is dominated by shocks. We have observed several transitions of HNCO towards L1157-mm and two positions (B1 and B2) in the blue lobe of the molecular outflow. The HNCO line profiles exhibit the same characteristics of other well-known shock tracers like CH3OH, H2CO, SO or SO2. HNCO, together with SO2 and OCS, are the only three molecules detected so far whose emission is much more intense in B2 than in B1, making these species valuable probes of chemical differences along the outflow. The HNCO abundance with respect to H2 is 0.4-1.8 10^-8 in B1 and 0.3-1 10^-7 in B2. These abundances are the highest ever measured, and imply an i...

  12. ULTRAFAST OUTFLOWS: GALAXY-SCALE ACTIVE GALACTIC NUCLEUS FEEDBACK

    International Nuclear Information System (INIS)

    We show, using global three-dimensional grid-based hydrodynamical simulations, that ultrafast outflows (UFOs) from active galactic nuclei (AGNs) result in considerable feedback of energy and momentum into the interstellar medium (ISM) of the host galaxy. The AGN wind interacts strongly with the inhomogeneous, two-phase ISM consisting of dense clouds embedded in a tenuous, hot, hydrostatic medium. The outflow floods through the intercloud channels, sweeps up the hot ISM, and ablates and disperses the dense clouds. The momentum of the UFO is primarily transferred to the dense clouds via the ram pressure in the channel flow, and the wind-blown bubble evolves in the energy-driven regime. Any dependence on UFO opening angle disappears after the first interaction with obstructing clouds. On kpc scales, therefore, feedback by UFOs operates similarly to feedback by relativistic AGN jets. Negative feedback is significantly stronger if clouds are distributed spherically rather than in a disk. In the latter case, the turbulent backflow of the wind drives mass inflow toward the central black hole. Considering the common occurrence of UFOs in AGNs, they are likely to be important in the cosmological feedback cycles of galaxy formation.

  13. Screen Channel Liquid Acquisition Device Outflow Tests in Liquid Hydrogen

    Science.gov (United States)

    Hartwig, Jason W.; Chato, David J.; McQuillen, J. B.; Vera, J.; Kudlac, M. T.; Quinn, F. D.

    2013-01-01

    This paper presents experimental design and test results of the recently concluded 1-g inverted vertical outflow testing of two 325x2300 full scale liquid acquisition device (LAD) channels in liquid hydrogen (LH2). One of the channels had a perforated plate and internal cooling from a thermodynamic vent system (TVS) to enhance performance. The LADs were mounted in a tank to simulate 1-g outflow over a wide range of LH2 temperatures (20.3 - 24.2 K), pressures (100 - 350 kPa), and flow rates (0.010 - 0.055 kg/s). Results indicate that the breakdown point is dominated by liquid temperature, with a second order dependence on mass flow rate through the LAD. The best performance is always achieved in the coldest liquid states for both channels, consistent with bubble point theory. Higher flow rates cause the standard channel to break down relatively earlier than the TVS cooled channel. Both the internal TVS heat exchanger and subcooling the liquid in the propellant tank are shown to significantly improve LAD performance.

  14. FAQs about Catheter-Associated Urinary Tract Infection

    Science.gov (United States)

    ... Tract Infection” What is “catheter-associated urinary tract infection”? A urinary tract infection (also called “UTI”) is an infection in the urinary system, which includes the bladder (which stores the ...

  15. Diagnostic imaging of cardiac hypertrophy

    International Nuclear Information System (INIS)

    As imaging techniques for cardiac hypertrophy, the ultrasonic dimension gauze technique, echocardiography, ventriculography and the RI technique including emission RI tomography were outlined. (Chiba, N.)

  16. Martian groundwater outflow processes and morphology; reconstruction of paleohydrology using landscape evolution experiments

    Science.gov (United States)

    Marra, Wouter A.; Kleinhans, Maarten G.; de Jong, Steven M.; Hauber, Ernst

    2015-04-01

    Groundwater played an important role in the aqueous history of Mars but how, how long, and with what intensity remains unclear. Two types of fluvial landforms related to groundwater emergence are the giant outflow channels and the disputed sapping valleys. Understanding of the relation between subsurface and surface processes is slim, which limits inferences of climate implications from the observable morphology. We aim to increase this understanding and to apply this knowledge to Martian cases to reconstruct former hydrological conditions. Using a series of sandbox experiments, we investigated formative processes of valleys formed by groundwater. These experiments showed the morphology and processes of groundwater sapping and pressurized groundwater outflow (see Marra et al, 2014, Icarus doi:10.1016/j.icarus.2013.12.026) and further focused on landscape characteristics of groundwater sapping sourced locally or distally, and identified various processes linked to pressurized groundwater outbursts including the formation and eruption of subsurface reservoirs that can explain the high reconstructed discharges of large outflow valleys (see Marra et al, 2014, JGR doi:10.1002/2014JE004701). Based on the experiments, we identified novel morphological indicators for groundwater outflow in the outflow channel region of Lunae and Ophir Plana. These, in combination with the classic outflow features, show a clear trend of increasing outflow magnitude with decreasing elevation to the northeast, indicating a head from a common aquifer. The putative aquifer we identified was likely recharged by infiltration over the Tharsis region. Outflow channel activity peaked in the Hesperian, but continued in the Amazonian at a lower magnitude. Our results agree well with groundwater recharge in the Noachian and Early Hesperian, corresponding to a climate that sustained an active hydrological cycle. Furthermore, the large outflow events require a confining layer to build up enough pressure

  17. The physics and the structure of the quasar-driven outflow in Mrk 231

    Science.gov (United States)

    Cicone, C.; Feruglio, C.; Maiolino, R.; Fiore, F.; Piconcelli, E.; Menci, N.; Aussel, H.; Sturm, E.

    2012-07-01

    Massive AGN-driven outflows are invoked by AGN-galaxy co-evolutionary models to suppress both star formation and black hole accretion. Massive molecular outflows have been discovered in some AGN hosts. However, the physical properties and structures of these AGN-driven molecular outflows are still poorly constrained. Here we present new IRAM PdBI observations of Mrk 231, the closest quasar known, targeting both the CO(1-0) and CO(2-1) transitions. We detect broad wings in both transitions, which trace a massive molecular outflow moving with velocities of up to 800 km s-1. The wings are spatially resolved at high significance levels (5-11σ), indicating that the molecular outflow extends to the kpc scale. The CO(2-1)/CO(1-0) ratio of the red broad wings is consistent with the ratio observed in the narrow core, while the blue broad wing is less excited than the core. The latter result suggests that quasar-driven outflow models invoking shocks (which would predict higher gas excitation) are inappropriate for describing the bulk of the outflow in Mrk 231. However, we note that within the central 700 pc the CO(2-1)/CO(1-0) ratio of the red wing is slightly, but significantly, higher than in the line core, suggesting that shocks may play a role in the central region. We also find that the average size of the outflow anticorrelates with the critical density of the transition used as a wind tracer. This indicates that, although diffuse and dense clumps coexist in the outflowing gas, dense outflowing clouds have shorter lifetimes and that they evaporate into the diffuse component along the outflow or, more simply, that diffuse clouds are more efficiently accelerated to larger distances by radiation pressure.

  18. Cardiac manifestations of myotonic dystrophy type 1

    DEFF Research Database (Denmark)

    Petri, Helle; Vissing, John; Witting, Nanna; Bundgaard, Henning; Køber, Lars

    2012-01-01

    To estimate the degree of cardiac involvement regarding left ventricular ejection fraction, conduction abnormalities, arrhythmia, risk of sudden cardiac death (SCD) and the associations between cardiac involvement and cytosine-thymine-guanine (CTG)-repeat, neuromuscular involvement, age and gender...

  19. Antifibrinolytics in cardiac surgery

    Directory of Open Access Journals (Sweden)

    Achal Dhir

    2013-01-01

    Full Text Available Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended. Significant bleeding during cardiac surgery, enough to cause re-exploration and/or blood transfusion, increases morbidity and mortality. Hyper-fibrinolysis is one of the important contributors to increased bleeding. This knowledge has led to the use of anti-fibrinolytic agents especially in procedures performed under cardiopulmonary bypass. Nothing has been more controversial in recent times than the aprotinin controversy. Since the withdrawal of aprotinin from the world market, the choice of antifibrinolytic agents has been limited to lysine analogues either tranexamic acid (TA or epsilon amino caproic acid (EACA. While proponents of aprotinin still argue against its non-availability. Health Canada has approved its use, albeit under very strict regulations. Antifibrinolytic agents are not without side effects and act like double-edged swords, the stronger the anti-fibrinolytic activity, the more serious the side effects. Aprotinin is the strongest in reducing blood loss, blood transfusion, and possibly, return to the operating room after cardiac surgery. EACA is the least effective, while TA is somewhere in between. Additionally, aprotinin has been implicated in increased mortality and maximum side effects. TA has been shown to increase seizure activity, whereas, EACA seems to have the least side effects. Apparently, these agents do not differentiate between pathological and physiological fibrinolysis and prevent all forms of fibrinolysis leading to possible thrombotic side effects. It would seem prudent to select the right agent knowing its risk-benefit profile for a given patient, under the given circumstances.

  20. [Urinary tract infection in pregnancy].

    Science.gov (United States)

    Duarte, Geraldo; Marcolin, Alessandra Cristina; Quintana, Silvana Maria; Cavalli, Ricardo Carvalho

    2008-02-01

    Several factors cause urinary tract infection (UTI) to be a relevant complication of the gestational period, aggravating both the maternal and perinatal prognosis. For many years, pregnancy has been considered to be a factor predisposing to all forms of UTI. Today, it is known that pregnancy, as an isolated event, is not responsible for a higher incidence of UTI, but that the anatomical and physiological changes imposed on the urinary tract by pregnancy predispose women with asymptomatic bacteriuria (AB) to become pregnant women with symptomatic UTI. AB affects 2 to 10% of all pregnant women and approximately 30% of these will develop pyelonephritis if not properly treated. However, a difficult-to-understand resistance against the identification of AB during this period is observed among prenatalists. The diagnosis of UTI is microbiological and it is based on two urine cultures presenting more than 10(5) colonies/mL urine of the same germ. Treatment is facilitated by the fact that it is based on an antibiogram, with no scientific foundation for the notion that a pre-established therapeutic scheme is an adequate measure. For the treatment of pyelonephritis, it is not possible to wait for the result of culture and previous knowledge of the resistance profile of the antibacterial agents available for the treatment of pregnant women would be the best measure. Another important variable is the use of an intravenous bactericidal antibiotic during the acute phase, with the possibility of oral administration at home after clinical improvement of the patient. At our hospital, the drug that best satisfies all of these requirements is cefuroxime, administered for 10-14 days. Third-generation cephalosporins do not exist in the oral form, all of them involving the inconvenience of parenteral administration. In view of their side effects, aminoglycosides are considered to be inadequate for administration to pregnant women. The inconsistent insinuation of contraindication of