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Sample records for carcinome adenoide kystique

  1. Adenoid cystic carcinoma of the head and neck; Les carcinomes adenoides kystiques de la tete et du cou

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    Haddad, H.; Riahi, H.; Chekrine, T.; Benchakroun, N.; Jouhadi, H.; Tawfiq, N.; Sahraoui, S.; Benider, A. [Centre d' oncologie Ibn-Rochd, Casablanca, (Morocco)

    2007-11-15

    The adenoid cystic carcinoma or cylindroma develop principally from salivary glands. It is the most frequently at the level of head and neck. The aim of this work is to analyse the therapy data and to determine the prognostic factors of adenoid cystic carcinomas through a retrospective study. (N.C.)

  2. Exclusive irradiation of cyst adenoid carcinomas: contribution of a dose complement in stereotactic mode; Irradiation exclusive des carcinomes adenoides kystiques: role d'un complement de dose en mode stereotaxique

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    Coche-Dequeant, B.; Lefebvre, J.L.; Lacornerie, T.; Lartigau, E. [Centre Oscar-Lambret, 59 - Lille (France); Attar, M. [King Abdulaziz University Hospital, Jeddah, Arabie saoudite (Saudi Arabia)

    2009-10-15

    The cyst adenoid carcinoma is a rare malignant tumor that reaches principally the salivary glands; It is characterized by a clinical aggressiveness, the presence of peri neural invasions, frequent local recurrences and a high rate of metastases dissemination at delayed distance. The treatment is surgery with a postoperative adjuvant radiotherapy. for the patients suffering of inoperable tumors, the exclusive radiotherapy gives bad results with tests of use of heavy particles. The place of a hypo fractionated treatment on a stereotactic mode has not been evaluated, especially in dose complement after three dimensional irradiation. The purpose was to answer the following question if the Cyberknife was useful to deliver a complement of hypo fractionated stereotactic dose for the inoperable head and neck tumors. The limited number of patients does not allow a definitive conclusion. however, this therapy option seems interesting for the inoperable tumors subject to the management of the toxicity induced by the treatment. The evaluation of the irradiation volumes remains the critical element for the feasibility of this kind of protocol. (N.C.)

  3. Literature review on the role of radiotherapy in the treatment of nasopharyngeal cystic adenoid carcinomas about two cases; Revue de la litterature sur la place de la radiotherapie dans le traitement des carcinomes adenoides kystiques du nasopharynx a propos de deux cas

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    Hemmich, M.; Hassouni, K.; Elkacemi, H.; Errachdi, A.; Mouhajir, N.; Zaidi, H.; Benjaafar, N. [Institut national d' oncologie, Rabat (Morocco)

    2011-10-15

    The authors discuss the characteristics and the radiotherapy treatment procedures of cystic adenoid carcinomas, and more precisely the treatment of two of such cases of nasopharyngeal carcinomas. The first one had an incomplete resection surgery followed by curing radiotherapy: he has then been in local-regional control situation for 8 months. The second one had lung metastases, was treated chemotherapy and radiotherapy (decompressive treatment), and died six months after diagnosis. Radiotherapy is considered to be the treatment basis, whereas chemotherapy is a matter of controversy. Short communication

  4. [A new outlook on adenoid hypertrophy: adenoids or adenoid disease?].

    Science.gov (United States)

    Antoniv, V F; Aksenov, V M; Antoniv, T V; Portianoĭ, M N; Perekrest, A I

    2004-01-01

    Hypertrophy of the pharyngeal tonsil affects functions of some organs and systems producing negative effects on physical and mental development of the child. The existing classification based of the tonsil size does not reflect the complexity of the pathological process. "Adenoid disease" is thought to be a more adequate term. A new classification of adenoid disease is proposed. Indications for conservative and surgical treatments can be well formulated with the new classification. The authors prefer adenotomy as, in their opinion, adenectomy is not safe for health.

  5. Adult adenoid hypertrophy, is it persistent childhood adenoid hypertrophy?

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    Shama Shetty

    2016-01-01

    Full Text Available Objectives: Adult adenoid hypertrophy is not common. More number of cases of adult adenoid hypertrophy is detected in recent years due to the free availability of endoscopes. The aim of this study is to know the etiopathology of adenoid hypertrophy in adults. Materials and Methods: Twenty-five cases of adult adenoid hypertrophy who underwent adenoidectomy were studied in our institution over a period of 5 years from 2008 to 2013. All the patients underwent diagnostic nasal endoscopy, and associated sinus and nasal pathology were studied. Results: Of 25 cases, 12 were males and 13 were females. In our study adult adenoid hypertrophy was more common in second and third decade. Nasal obstruction was main symptom in 80% of our cases. Allergic symptoms were seen in 28%, headache in 24%, and repeated throat infection in 20%. Adenoidectomy with tonsillectomy was done in 5 cases, adenoidectomy with septoplasty in 5 cases, septoplasty with turbinectomy along with adenoidectomy in 7 cases, functional endoscopic sinus surgery with adenoidectomy in 3 cases, adenoidectomy with tympanoplasty in 2 cases, myringotomy with grommet insertion in 2 patients, and isolated adenoidectomy in 1 patient. Conclusion: Since highest number of cases in our study is in early adulthood, we believe that adenoid hypertrophy is persistence of childhood hypertrophy.

  6. Correlation between adenoidal nasopharyngeal ratio and symptoms of enlarged adenoids in children with adenoidal hypertrophy

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    Taiwo Olugbemiga Adedeji

    2016-01-01

    Full Text Available Background: Adenoid hypertrophy is one of the most common health problems affecting the paediatric population. This study aims to correlate adenoidal nasopharyngeal ratio (ANR with symptoms of enlarged adenoids in children with enlarged adenoids. Materials and Methods: It was a year, cross-sectional, hospital-based study conducted at Lautech Teaching Hospital, Osogbo. ANR was determined by dividing adenoidal depth with nasopharyngeal depth on the plain lateral radiographs. Results: A total of 90 consecutive children consisting of 61 males and 29 females were included in the study with M:F ratio of 2.1:1. Their ages ranged from 8 months to 11 years. All the patients presented with nasal obstruction, mouth breathing and noisy breathing. Majority (64.5% had severe obstructions with preponderance among children of 3-5 years (39.9%. Linear regression analysis showed significant association between age and ANR (t = 10.447, P < 0.001. There was high significant association (P < 0.05 between presenting symptoms and degree of nasopharyngeal airway obstruction; for snoring (r = 0.251, P = 0.000, sleep apnoea (r = 0.594, P = 0.000, nasal discharge (r = 0.314, P = 0.001, excessive daytime sleepiness (r = 0.219, P = 0.019 and failure to thrive (r = 0.240, P = 0.011. Conclusion: Lateral X-ray of the nasopharynx is an effective tool to evaluate children with suspected adenoid hypertrophy. It correlates well with patients′ symptoms and provides objective measures of adenoid hypertrophy.

  7. ADENOIDS IN ADULT SIBLINGS : IS IT FAMILIAL ?

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    Sulabha M Naik

    2012-10-01

    Full Text Available Waldeyer’s ring is a collection of lymphoid tissue at the entrance to the aerodigestive tract.Adenoids are present in the nasopharyx.They begin to regress from the age of 8 to 10 years and nearly always disappear by adulthood.The persistent presence of adenoid tissue after puberty has been reported in literature.While investigating a case of nasal obstruction in adults,the possibility of persistence of adenoid tissue should be borne in mind.

  8. Adenoid Hypertrophy in Adults: A case Series

    OpenAIRE

    Rout, Manas Ranjan; Mohanty, Diganta; Y Vijaylaxmi; Bobba, Kamlesh; Metta, Chakradhar

    2012-01-01

    Adenoid hypertrophy is common in children. Size of the adenoid increases up to the age of 6 years, then slowly atrophies and completely disappears at the age of 16 years. Adenoid hypertrophy in adults is rare. Present study shows that adenoid hypertrophy is now increasing in adults because of various causes. Study has been conducted in the Department of ENT and Head & Neck Surgery, Alluri Sitarama Raju Academy of Medical science, Eluru, Andhra Pradesh, India. Study shows that incidence of ade...

  9. Adenoid Hypertrophy in Adults: A case Series.

    Science.gov (United States)

    Rout, Manas Ranjan; Mohanty, Diganta; Vijaylaxmi, Y; Bobba, Kamlesh; Metta, Chakradhar

    2013-07-01

    Adenoid hypertrophy is common in children. Size of the adenoid increases up to the age of 6 years, then slowly atrophies and completely disappears at the age of 16 years. Adenoid hypertrophy in adults is rare. Present study shows that adenoid hypertrophy is now increasing in adults because of various causes. Study has been conducted in the Department of ENT and Head & Neck Surgery, Alluri Sitarama Raju Academy of Medical science, Eluru, Andhra Pradesh, India. Study shows that incidence of adenoid hypertrophy is increasing as the cause of nasal obstruction in adults. This study identified the different causes of adenoid hypertrophy in adult patients. The common causes of adenoid hypertrophy in adults are chronic infection and allergy. Pollution and smoking are also important predisposing factors. Sometimes it is also associated with sinonasal malignancy, lymphoma and HIV infection. Study shows that 21 % of adult nasal obstruction is due to adenoid hypertrophy. But in case of the patient with chronic tonsillitis only 9 % were associated with adenoid hypertrophy. Males are more commonly involved (70 %) then female, may be because of out door activities and more commonly exposed to pollutants. And most commonly involved age group is 16-25 years (60 %). Majority of the cases with adenoid hypertrophy are associated with infection and allergy i.e. descending infection in 33.3 % cases, ascending infection in 20 % cases and allergic rhinitis in 30 % cases. Association of malignant sinonasal tumors, non Hodgkin's lymphoma and HIV infections are rare i.e. 3.3 % each. So any cases of adult adenoid hypertrophy should be treated seriously to exclude the dangerous causes.

  10. [Multifocus or recurrent carcinoma adenoides cysticum].

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    Wójtowicz, P; Sujkowska, U; Kukwa, A; Sobczyk, G; Misztela, T

    1995-01-01

    Authors present the case of carcinoma adenoides cysticum, which was located in small salivary glands of palatum. After surgical treatment and radiotherapy during 3 years observation of the patient two new ca adenoides cysticum focus were noticed. It can give evidence of cancer multifocus of cancer recurrents.

  11. Adenoid basal cell carcinoma and its mimics

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    Sujata Jetley

    2013-01-01

    Full Text Available Basal cell carcinoma (BCC is the most common malignant tumor of skin. The most common site (80% is head and neck. BCC exhibits a varied morphology such as adenoid, keratotic, sebaceous, basosquamous, apocrine, eccrine or fibroepithelial. Tumors with a similar histopathological picture are cutaneous adenoid cystic carcinoma and primary cutaneous cribriform apocrine carcinoma. Immunohistochemistry, along with clinical findings, acts as an adjunct in reaching an accurate diagnosis. Here, we present an interesting case of adenoid BCC in a 55-year-old man.

  12. Subglottic adenoid cystic carcinoma mistaken for asthma

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    Hua-lin WANG; Lin XU; Fu-jun LI

    2009-01-01

    of the tumor. The diagnosis of subglottic adenoid cystic carcinoma should be considered in patients who are characterized by dyspnea, cough, and stridor, but do not respond to regular anti-asthmatic therapy.

  13. Adenoid cystic carcinoma of the lacrimal gland

    DEFF Research Database (Denmark)

    von Holstein, Sarah L; Fehr, André; Persson, Marta;

    2013-01-01

    To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival.......To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival....

  14. Bacteriology of symptomatic adenoids in children

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    Aroor Rajeshwary

    2013-01-01

    Full Text Available Background: Children with adenoid hypertrophy have been shown to harbor pathogenic bacteria in the nasopharynx despite antibiotics. Removal of the adenoid is associated with a reduction in the bacterial count. Aims: The study was done to determine the bacteriology of the adenoid tissue in chronic adenotonsillitis and adenoid hypertrophy, and determine the antibiotic sensitivity of potential pathogens. Materials and Methods : This is a descriptive study conducted on 100 patients aged between three and twelve years who underwent adenotonsillectomy/adenoidectomy. After adenoidectomy, the specimen along with the swab taken from the surface of the adenoid was sent for microbiological examination. After 48 and 96 hours, the microbial growth was identified and the antibiotic-sensitivity pattern of the isolate was studied. Results: Aerobic organisms grew in 93% of the specimens and anaerobic organisms in 68%, whereas 7% had no growth. The surface was predominated by commensals and the pathogens were mainly found in the core. The predominant pathogens were Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus species. The organisms were resistant to penicillin but showed sensitivity to co-amoxiclav and ciprofloxacin. Co-amoxiclav and ciprofloxacin should be considered as the first line of medical treatment for adenotonsillar diseases. Conclusions: Infection is the main cause of adenoid hypertrophy. Amoxicillin with potassium clavulanate and ciprofloxacin should be considered as the drugs of choice for all adenotonsillar diseases.Early and prompt treatment of adenoid hypertrophy with appropriate antibiotics will avoid unnecessary exposure to repeated antimicrobial therapy, thereby maintaining the beneficial effects of the normal adenoid flora.

  15. Montelukast in Adenoid Hypertrophy: Its Effect on Size and Symptoms

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    Farshid Shokouhi

    2015-11-01

    Conclusion:  Montelukast chewable tablets achieved a significant reduction in adenoid size and improved the related clinical symptoms of AH and can therefore be considered an effective alternative to surgical treatment in children with adenoid hypertrophy.

  16. Prevalence of Streptococcus Pneumoniae, Haemophilus Influenzae and Moraxella Catarrhalis in Adenoid Tissues of Children with Adenoid Hypertrophy

    OpenAIRE

    SS Khoramrooz; A. Mirsalehian; Emaneini, M.; A Sharifi; S A Khosravani; Jabalameli, F.; M.Aligholi; D Darban-Sarokhalil; M Mirzaii; A Bazargani

    2012-01-01

    Background & aim: Chronic infection of the adenoid tissue is one of the causes of hypertrophy. Adenoids are considered to be as reservoirs of pathogenic bacteria such as Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae. The aim of this study was to determine the prevalence of mentioned bacteria in children with adenoid hypertrophy. Methods: A total of 113 children with adenoid hypertrophy who underwent adenoidectomy were included in this study. Subsequently, ad...

  17. Epithelioma adenoides cysticum: genetic update.

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    Anderson, D E; Howell, J B

    1976-09-01

    Epithelioma adenoides cysticum (EAC) is a well-known genodermatosis which follows an autosomal dominant mode of inheritance. Questions still remain, however, concerning an apparent excess of females with EAC. An analysis of nineteen previously published pedigrees and one newly ascertained pedigree, which in the aggregate included over 175 cases of EAC, induced no excess of affected females, but rather, a marked deficit males. This deficiency was not the consequence of sex linkage or decreased viability, and was most evident in large pedigrees and sibships, sibships not including the probands, and late birth orders. In these situations, the penetrance of EAC in male gene carriers was only 50%, but was close to 100% in female gene carries. Under maximum detection conditions, i.e. small pedigrees, small sibships, sibships containing the proband, and early birth orders, the penetrance in males increased to 85% and was again close to 100% in females. These findings suggested that the deficit of affected males was best explained by a comination of lessened expressivity and penetrance, effects which were magnified under situations of poor detection. A review of familial cases of EAC indicated no consistent associated anomalies such as those that characterize the naevoid basal cell carcinoma syndrome.

  18. Akt Inhibitor MK2206 in Treating Patients With Progressive, Recurrent, or Metastatic Adenoid Cyst Carcinoma

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    2016-06-14

    Recurrent Oral Cavity Adenoid Cystic Carcinoma; Recurrent Salivary Gland Carcinoma; Salivary Gland Adenoid Cystic Carcinoma; Stage IVA Major Salivary Gland Carcinoma; Stage IVA Oral Cavity Adenoid Cystic Carcinoma; Stage IVB Major Salivary Gland Carcinoma; Stage IVB Oral Cavity Adenoid Cystic Carcinoma; Stage IVC Major Salivary Gland Carcinoma; Stage IVC Oral Cavity Adenoid Cystic Carcinoma

  19. Le lymphangiome kystique du plancher buccal étendu a la région sous mandibulaire de l’adulte

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    Ali, Elboukhari; Karim, Nador; Hicham, Attifi; Mohamed, Zalagh

    2016-01-01

    Les lymphangiomes kystiques sont des lésions congénitales bénignes prédominantes nettement au niveau de la région de la tête et du cou plus particulièrement dans le triangle cervical postérieur. Ces malformations des vaisseaux lymphatiques sont fréquemment diagnostiquées chez l'enfant. Nous rapportons le cas clinique d'un lymphangiome kystique du plancher buccal ayant survenu chez un adulte de 28 ans et qui s'est étendu progressivement vers la région sous mandibulaire gauche. La tumeur suspecté cliniquement a été bien exploré à la tomodensitométrie. Le traitement a consisté en une exérèse complète par voie endobuccale avec étude histologique qui a confirmé le diagnostic d'un lymphangiome kystique macroscopique. Le suivi à quatre ans n'a montré aucune récidive. PMID:27795797

  20. MRI of nasopharyngeal adenoid hypertrophy.

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    Surov, Alexey; Ryl, Ina; Bartel-Friedrich, Sylvia; Wienke, Andreas; Kösling, Sabrina

    2016-10-01

    Nasopharyngeal adenoid hypertrophy (NAH) is a typical benign lesion. Due to involution, nasopharyngeal lymphatic tissue usually is not found in adults beyond the 30th to 40th year of life. However, occasionally NAH has been recognized after the 50th or 60th year. The aim of this study is to identify the frequency of NAH and to analyze its MRI findings in different age groups. From 2007 to 2011, 6693 MR investigations of the head were performed at our institution. MRI was obtained with a 1.5 T MRI device. NAH was identified in 18.0% of the patients. The frequency of NAH varied from 60.3% to 1.0% in the different age groups. The mean size of NAH was 23.2 ± 4.5 mm in cranio-caudal, 31.1 ± 5.2 mm in left-right, and 14.2 ± 4.1 mm in the anterior-posterior direction. The left-right and cranio-caudal sizes of NAH were largest in the 0-9 age group and decreased with age. On T1-w images most lesions (95.4%) were hypointense in comparison to the adjacent musculature. On T2-w fat-saturated images 82.4% of the lesions were hyperintense. After intravenous administration of contrast medium most lesions showed a slight enhancement (58.6%). Moderate enhancement was seen in 32.4% and a marked enhancement was identified in 9.0%. In the 0-9 age group most lesions showed a slight enhancement. Cysts within NAH were identified in 433 cases (35.9%). The frequency of cysts increased continuously with age, namely from 10.9% to 65.2%.

  1. The mutational landscape of adenoid cystic carcinoma

    NARCIS (Netherlands)

    Ho, A.S.; Kannan, K.; Roy, D.M.; Morris, L.G.T.; Ganly, I.; Katabi, N.; Ramaswami, D.; Walsh, L.A.; Eng, S.; Huse, J.T.; Zhang, J.; Dolgalev, I.; Huberman, K.; Heguy, A.; Viale, A.; Drobnjak, M.; Leversha, M.A.; Rice, C.E.; Singh, B.; Iyer, N.G.; Leemans, C.R.; Bloemena, E.; Ferris, R.L.; Seethala, R.R.; Gross, B.E.; Liang, Y.; Sinha, R.; Peng, L.; Raphael, B.J.; Turcan, S.; Gong, Y.; Schultz, N.; Kim, S.; Chiosea, S.; Shah, J.P.; Sander, C.; Lee, W.; Chan, T.A.

    2013-01-01

    Adenoid cystic carcinomas (ACCs) are among the most enigmatic of human malignancies. These aggressive salivary gland cancers frequently recur and metastasize despite definitive treatment, with no known effective chemotherapy regimen. Here we determined the ACC mutational landscape and report the exo

  2. A New Clinical Scoring System for Adenoid Hypertrophy in Children

    OpenAIRE

    Shervin Sharifkashani; Payman Dabirmoghaddam; Maryam Kheirkhah; Rima Hosseinzadehnik

    2015-01-01

    Introduction: Chronic nasal obstruction due to adenoid hypertrophy is a very common disorder. Although the clinical assessment of adenoid hypertrophy is essential, its real value in young children is difficult to evaluate. The purpose of this prospective study was to validate a simple clinical score to predict the severity of adenoid obstruction and to evaluate the relationship between this method of clinical scoring with radiography and nasopharyngeal endoscopy. Materials and Methods: Ninety...

  3. Prevalence of Streptococcus Pneumoniae, Haemophilus Influenzae and Moraxella Catarrhalis in Adenoid Tissues of Children with Adenoid Hypertrophy

    Directory of Open Access Journals (Sweden)

    SS Khoramrooz

    2012-08-01

    Full Text Available Background & aim: Chronic infection of the adenoid tissue is one of the causes of hypertrophy. Adenoids are considered to be as reservoirs of pathogenic bacteria such as Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae. The aim of this study was to determine the prevalence of mentioned bacteria in children with adenoid hypertrophy. Methods: A total of 113 children with adenoid hypertrophy who underwent adenoidectomy were included in this study. Subsequently, adenoidectomy was performed under general anesthesia. All of the adenoid samples were evaluated for bacterial infection by culture and PCR methods. Results: Streptococcus. pneumoniae was the most common (33.6% bacteria isolated by culture followed by H. influenzae (22.9% and M. catarrhalis (9.7%. PCR method detected S. pneumoniae, H. influenzae and M. catarrhalis in 31%, 29.2% and 9.7% of samples respectively. Conclusion: Streptococcus. Pneumonia, H. influenzae and M. catarrhalis are isolated with different frequency in patients with adenoid hypertrophy.

  4. Assessment of nasopharyngeal airway and adenoid by MRI

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    Jung, Myung Suk; Hur, Gham; Kim, Yong Hoon; Joe, Eun Ok; Lee, Seong Sook [Sanggae Paik Hospital, College of Medicine, Inje University, Seoul (Korea, Republic of)

    1993-09-15

    Adenoid is a kind of tonsil located in the posterior wall of nasopharynx. Enlargement of the adenoid can produce obstruction of the nasopharynx and Eustachian tube. Disturbance in discharge of nasal and paranasal secretions can be a cause of chronic rhinitis, sinusitis, and otitis media. Diagnosis of enlarged adenoid simply by inspection is different due to its location. Measurement of nasopharyngeal airway and adenoid using lateral radiographs of nasopharynx may be inaccurate for magnification and rotation. It was some limitations in demonstrating the actual state of nasopharyngeal airway and adenoid because it gives only two dimensional information. The authors measured the size and areas of nasopharyngeal airway and adenoid using MRI with sagittal and oblique coronal pilot views of T1 weighted spin echo. We categorized the patients into 4 groups according to the scoring system by symptoms such as apnea, mouth breathing, and snoring. The results of several measurment and their ratios were evaluated in these 4 categorized patients. The ratios of area of adenoid and nasopharyngeal airway (AA/Na) in each patient group were 6.52, 7.76, 10.53, 15.93, respectively. And the ratios of adenoid and nasopharyngeal airway (A/N) by Fujioka's method were 0.6, 0.65, 0.69, 0.71, respectively. We found that AA/Na might be the most effective index as an objective indicator in the evaluation of nasopharyngeal obstruction by the enlarged adenoid.

  5. Adenoids in children: Advances in immunology, diagnosis, and surgery.

    Science.gov (United States)

    Brambilla, Ilaria; Pusateri, Alessandro; Pagella, Fabio; Caimmi, Davide; Caimmi, Silvia; Licari, Amelia; Barberi, Salvatore; Castellazzi, Annamaria M; Marseglia, Gian Luigi

    2014-04-01

    Adenoids are strategically located for mediating local and regional immune functions as they are exposed to antigens from both the outside air and the alimentary tract. Recurrent or chronic respiratory infections can induce histomorphological and functional changes in the adenoidal immunological barrier, sometimes making surgical treatment necessary. Our aim in this review is to summarize the crucial points about not only the immunological histopathology of adenoidal tissue, especially in patients with adenoid hypertrophy, but also the most common and useful diagnostic techniques and surgical options.

  6. Paediatric refractory rhinosinusitis secondary to hypertrophied adenoids: management and review of literature.

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    Gautham MK

    2014-06-01

    Full Text Available Background /Objectives: Hypertrophied adenoids are the most common cause of refractory sinusitis in paediatric age. We study 42 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy (EAA and conventional adenoidectomy (CA. Materials and method: 42 cases of chronic refractory sinusitis with adenoid facies secondary to hypertrophied adenoids were randomized into 2 groups during the study period of 12 months from August 2012 to July 2013. Group A (n=21 underwent endoscope assisted adenoidectomy and Group B(n=21 underwent conventional adenoidectomy. Result: Endoscopic assisted adenoidectomy proves to be more effective in managing adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia. Conclusion: Visualization of the adenoid mass using endoscope helps complete removal of the diseased adenoids. Endoscopic assisted adenoidectomy is treatment of choice in adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia and more effective than conventional adenoidectomy.

  7. Asymptomatic cardiopulmonary changes caused by adenoid hypertrophy.

    Science.gov (United States)

    Abdel-Aziz, Mosaad

    2011-07-01

    Adenoid hypertrophy is the most common cause of pediatric upper airway obstruction, and it can lead to cardiopulmonary complications such as pulmonary hypertension, cor pulmonale, and even heart failure. The aim of this study was to detect the asymptomatic cardiopulmonary changes that could happen in children with adenoid hypertrophy.Eighty children with adenoid hypertrophy were included in this study. Chest x-ray was used to assess the cardiothoracic ratio, whereas echocardiography was used for measuring the pulmonary arterial pressures, right ventricular diastolic filling parameters, and right ventricular end-diastolic diameters. All patients underwent adenoidectomy with or without tonsillectomy, and they were subjected again to echocardiographic assessment 6 months after the operation. No patient showed an increase in the cardiothoracic ratio on x-ray. Preoperative echocardiography showed an increase in pulmonary artery pressure (22.7 [SD, 3.8] mm Hg), a decrease in right ventricular diastolic filling parameters (E/A = 1.03 [SD, 0.17]), and an increase in right ventricular end-diastolic diameters (1.89 [SD, 0.19] cm). Postoperatively, pulmonary artery pressure decreased to 17.2 [SD, 2.1] mm Hg, right ventricular diastolic filling (E/A) increased to 1.25 [SD, 0.11], and right ventricular end-diastolic diameters decreased to 1.68 [SD, 0.12] cm. The comparison between preoperative and postoperative results for each individual parameter was statistically significant. Clinically asymptomatic cardiopulmonary changes due to adenoid hypertrophy are not rare. Early diagnosis and treatment of upper airway obstruction can prevent these serious complications. Echocardiographic examination should be recommended for these patients as a part of preoperative preparation to avoid anesthetic complications.

  8. Radiographic adenoid evaluation - suggestion of referral parameters

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    Murilo F.N. Feres

    2014-06-01

    Full Text Available OBJECTIVE: this study aimed to evaluate the usefulness of current radiographic measurements, which were originally conceived to evaluate adenoid hypertrophy, as potential referral parameters. METHODS: children aged from 4 to 14 years, of both genders, who presented nasal obstruction complaints, were subjected to cavum radiography. Radiographic examinations (n = 120 were evaluated according to categorical and quantitative parameters, and data were compared to gold-standard videonasopharyngoscopic examination, regarding accuracy (sensitivity, negative predictive value, specificity, and positive predictive value. RESULTS: radiographic grading systems presented low sensitivity for the identification of patients with two-thirds choanal space obstruction. However, some of these parameters presented relatively high specificity rates when three-quarters adenoid obstruction was the threshold of interest. Amongst the quantitative variables, a mathematical model was found to be more suitable for identifying patients with more than two-thirds obstruction. CONCLUSION: this model was shown to be potentially useful as a screening tool to include patients with, at least, two-thirds adenoid obstruction. Moreover, one of the categorical parameters was demonstrated to be relatively more useful, as well as a potentially safer assessment tool to exclude patients with less than three-quarters obstruction, to be indicated for adenoidectomy.

  9. Adenoid facies and chronic refractory rhinosinusitis managed by endoscopic-assisted adenoidectomy

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    Sudhir M Naik

    2015-12-01

    Full Text Available Background /Objectives: To study 30 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy. Materials and method: 7 cases of adenoid facies and 23 cases of chronic refractory rhinosinusitis with adenoiditis were managed by endoscopic assisted adenoidectomy during the study period of 12 months from August 2012 to July 2013. Result: endoscopic assisted adenoidectomy proves to be more effective in managing adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia. Conclusion: visualization of the adenoid mass using endoscope helps complete removal of the diseased adenoids. Endoscopic assisted adenoidectomy is treatment of choice in adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia and more effective than conventional adenoidectomy.

  10. Comparison between nasal endoscopic suction cutter treatment of adenoidal hypertrophy and blind adenoid scraping by spatula

    Institute of Scientific and Technical Information of China (English)

    Hong-Xia Zhang; Zhu-Lin Chen; Duo-Xi Mao; Jing Liu

    2016-01-01

    Objective:To analyze the wound degree during suction cutter treatment of adenoidal hypertrophy and its effect on postoperative ventilation function.Methods: A total of 112 patients with adenoidal hypertrophy were randomly divided into observation group and control group (n=56), control group received blind adenoid scraping by spatula, observation group received suction cutter treatment, and then differences in serum levels of inflammatory cytokines and apoptosis factors as well as nasal ventilation function and lung function indexes were compared between two groups of patients after treatment.Results:Inflammatory cytokines IL-4, IL-6, TNF-α, ECP and ICAM-1 content in serum of observation group 2d after treatment were lower than those of control group, and apoptotic factors survivin, caspase-3, sFas and sFasL content in serum were lower than those of control group (P<0.05); nasal ventilation function parameters TIR, TER, NPRi and NPRe levels of observation group 1 week after treatment were lower than those of control group while IC and EC levels were higher than those of control group, and pulmonary function parameters VT, MV, PIEF, FEF25%, FEF50% and FEF75% levels were higher than those of control group (P<0.05). Conclusions:Suction cutter treatment of adenoid hypertrophy outstandingly improves the patients’ ventilation function, and also has the advantage of small wound.

  11. Adenoid facies and chronic refractory rhinosinusitis managed by endoscopic-assisted adenoidectomy

    OpenAIRE

    2015-01-01

    Background /Objectives: To study 30 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy. Materials and method: 7 cases of adenoid facies and 23 cases of chronic refractory rhinosinusitis with adenoiditis were managed by endoscopic assisted adenoidectomy during the study period of 12 months from August 2012 to July 2013. Result: endoscopic assisted adenoidectomy proves to be more effective in m...

  12. Tympanometric Findings among Children with Adenoid Hypertrophy in Port Harcourt, Nigeria

    OpenAIRE

    Chibuike Nwosu; Mathilda Uju Ibekwe; Lucky Obukowho Onotai

    2016-01-01

    Introduction. Adenoid hypertrophy (AH) is a common childhood disorder. Adenoid plays a significant role in the pathogenesis of otitis media with effusion (OME). The aim of this study is to critically appraise the tympanometric finding among children with adenoid hypertrophy in Port Harcourt, Nigeria. Methodology. A Prospective, controlled study carried out among newly diagnosed cases of adenoid hypertrophy at the ENT clinic of the UPTH, between November 2014 and June 2015. Tympanometry was do...

  13. Unusual infections in resected adenoid of children: PCR for C. pneumonia, M. pneumonia, H. pylori.

    OpenAIRE

    Farhadi, Mohammad; Noorbakhsh, Samileh; Taj, Farideh Ebrahimi; Javahertrash, Naser; Tabatabaei, Azardokht; Bakhshyeh, Masomeh

    2013-01-01

    Abstract. Recurrent or chronic adenotonsillar infections mainly affect children.The possible role for infectious agents in adenoid hypertrophy have reported. Searching the DNAs (PCR) of M. pneumonia, C. pneumonia and H. pylori in resected adenoid of children with adenoid surgery. A cross-sectional study done in ENT and Pediatric Department of Rasul Akram Hospital during 2006-2008. 53 children with recurrent or chronic adenotonsillar infections candidate for adenoid surgery were selected .The ...

  14. A New Clinical Scoring System for Adenoid Hypertrophy in Children

    Directory of Open Access Journals (Sweden)

    Shervin Sharifkashani

    2015-01-01

    Full Text Available Introduction: Chronic nasal obstruction due to adenoid hypertrophy is a very common disorder. Although the clinical assessment of adenoid hypertrophy is essential, its real value in young children is difficult to evaluate. The purpose of this prospective study was to validate a simple clinical score to predict the severity of adenoid obstruction and to evaluate the relationship between this method of clinical scoring with radiography and nasopharyngeal endoscopy.   Materials and Methods: Ninety symptomatic children were enrolled into this study. The clinical score included difficulty of breathing during sleep, apnea, and snoring. We investigated the relationship between clinical scoring, nasal endoscopy, and radiographic findings.   Results: The clinical score correlated very well with endoscopic findings (P0.05 and endoscopic findings and imaging (P>0.05 was weak.    Conclusion:  Clinical findings could be used to select children for adenoidectomy, especially when endoscopic examination is not available or cannot be performed.

  15. Radiographic evaluation of adenoidal size in children: methods of measurement and parameters of normality; Avaliacao radiografica da adenoide em criancas: metodos de mensuracao e parametros da normalidade

    Energy Technology Data Exchange (ETDEWEB)

    Araujo Neto, Severino Aires de [Centro de Assistencia Integral a Saude da Mulher (CAISM), Campinas, SP (Brazil)]. E-mail: severinoaires@hotmail.com; Queiroz, Suelio Marinho de [Tomovale, Sao Jose dos Campos, SP (Brazil); Baracat, Emilio Carlos Elias [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Ciencias Medicas. Dept. de Pediatria; Pereira, Ines Minniti Rodrigues [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Ciencias Medicas. Dept. de Radiologia

    2004-12-01

    Radiograph of the nasopharynx is still the most commonly used imaging method to investigate the adenoidal tissue. Due to the variety and complexity of proposed methods to measure the adenoid size, some radiologists prefer subjective evaluation, which can, however, be imprecise and inaccurate. We review and describe several methods to determine the adenoid size, taking into account the practicity, accuracy and precision with the aim of pointing out the best methods to be applied in daily routine practice. (author)

  16. [Adenoid cystic carcinoma of the larynx, trachea and thyroid].

    Science.gov (United States)

    Gryczyński, M; Piotrowski, S

    1995-01-01

    The aim of this article was to describe rarely occurred carcinoma adenoides cysticum located in the larynx, trachea and thyroid. Epidemiology, clinical course and medical therapy was demonstrated. In reported case concerning 65-year old woman early bilateral paresis of vocal folds was observed as results of the perineural infiltration. That caused sudden laryngeal dyspnea. It is important to pay attention on local extensiveness of neoplasm. Besides changes in larynx, neoplastic infiltration was found in trachea, preesophageal tissues and right lobe of thyroid. For above reasons there is no possible to exclude thyroid as a primary tumor of carcinoma adenoides cysticum.

  17. Atypical case of primary intraosseous adenoid cystic carcinoma of mandible

    Directory of Open Access Journals (Sweden)

    D P Vinuth

    2013-01-01

    Full Text Available The Primary central salivary gland neoplasms of the mandible are infrequent. Their clinical and radiographic features may be similar to odontogenic tumors, which are otherwise common. Their accurate diagnosis becomes troublesome.Hence, diagnosis should depend on stringent diagnostic criteria. Adenoid cystic carcinoma is well known for its prolonged clinical course and its tendency for delayed onset of distant metastases. The long-term survival of these patients is therefore poor. Treatment modalities include surgery, radiotherapy and chemotherapy. The purpose of this paper is to report a case of primary central adenoid cystic carcinoma of mandible with an atypical presentation.

  18. Salivary adenoid cystic carcinoma in Denmark 1990-2005

    DEFF Research Database (Denmark)

    Bjørndal, Kristine; Krogdahl, Annelise; Therkildsen, Marianne H;

    2015-01-01

    AIM: To describe outcome and prognostic factors, including the effect of radiotherapy, in a consecutive national series of salivary gland adenoid cystic carcinomas. METHODS: From the national Danish salivary gland carcinoma database in the structure of DAHANCA, 201 patients diagnosed with adenoid...... cystic carcinoma, and treated with a curative intent, were identified in the period between 1990 and 2005. Variables necessary for statistical analyses were extracted from the database. RESULTS: The 10-year crude survival and disease specific survival rates were 58% and 75%, respectively. The 10-year...

  19. Adenoid Cystic Carcinoma of the Trachea Resulting in Fatal Asphyxia.

    Science.gov (United States)

    Huston, Butch; Froloff, Victor; Mills, Kelly; McGee, Michael

    2017-01-01

    Primary malignant tumors of the trachea are uncommon. The authors report a case of a 72-year-old female who died from asphyxia due to an undiagnosed obstructing adenoid cystic carcinoma of the trachea. The decedent became unresponsive while eating cereal and was pronounced upon arrival at the local hospital. The autopsy revealed a near occlusive tumor mass just superior to the bifurcation of the distal trachea. There was no evidence of aspiration. The death was the result of asphyxia due to obstruction of the trachea by an adenoid cystic carcinoma. This case demonstrates that an obstructive tumor mass may remain undiagnosed until an obstructive episode results in a sudden death.

  20. A RARE CASE OF ADENOID CYSTIC CARCINOMA OF ETHMOID SINUS

    Directory of Open Access Journals (Sweden)

    Bharath

    2013-02-01

    Full Text Available ABSTRACT: Adenoid cystic carcinoma is more common in minor sa livary glands, uncommon in parotid gland and rare in paranasal sinuses. These ar e more aggressive and fatal. Such tumors of the accessory nasal sinuses causing proptosis have be en reported so rarely in ophthalmic literature. An adult aged 31 years presented with pro ptosis of right eye, nasal obstruction and bleeding from right nose. CT scan showed soft tissu e attenuation mass with destruction of bony structures and extension to right orbit. Biopsy was done through trans nasal route. A histological diagnosis of Adenoid cystic carcinoma of ethmoid sinus was made

  1. Bacterial meningitis after radiofrequency diathermy for adenoid hypertrophy.

    Science.gov (United States)

    Nagasaki, Azusa; Sato, Atsuo; Shiro, Hiroyuki

    2014-06-01

    A 6-year-old otherwise healthy girl who underwent radiofrequency diathermy for adenoid hypertrophy presented with fever on the same day and was diagnosed as having bacterial meningitis 2 days later. Culture of cerebrospinal fluid indicated that the pathogens were penicillin-sensitive Streptococcus pneumoniae and methicillin-sensitive Staphylococcus aureus. The serotype of the causative pneumococcus, 11A, was not covered by the 7-valent pneumococcal conjugate vaccine the patient had been inoculated with. Although not previously reported, radiofrequency diathermy for adenoid hypertrophy can be considered a risk factor for bacteremia and meningitis.

  2. Les carcinomes epidermoïdes du scrotum: à propos de 7 cas avec revue de la litterature

    Science.gov (United States)

    Halfya, Ayoub; Elmortaji, Khalid; Redouane, Rabii; fethi, Meziane; Rafik, Amine; Mohamed, Ezzoubi; Abdessamad, Chlihi

    2015-01-01

    Quoique rare le carcinome épidermoïde du scrotum a un mauvais pronostic. Les Carcinomes du scrotum induite et - liées au travail sont moins fréquentes en raison d'une meilleure hygiène, vêtements de protection, et la sensibilisation de la cancérogénicité des huiles industrielles. L’épidémie à l'HPV a induit une augmentation de l'incidence. Le traitement de dépend toujours exérèse locale de la lésion primaire. La radiothérapie a peu de bénéfice thérapeutique dans le traitement d'un carcinome épidermoïde du scrotum. La bléomycine peut être utile comme traitement adjuvant pour les maladies ilio-inguinal généralisée avant la tentative exérèse, même si cela n'a pas encore été prouvé. Entre janvier 2011 au 1er janvier 2013, 7 patients atteints de carcinome épidermoïde ont été pris en charge, Trois patients ont présenté une localisation ganglionnaire. Les sept patients ont eu un traitement chirurgical par exérèse large avec reconstruction, Deux patients ont été adressé pour chimiothérapie.2 patients ont présenté une récidive, dont un est décédé. PMID:26113906

  3. Clinical and Epidemiological Characterization of Chronic Adenoiditis in Children

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    Daniel Reyes Concepción

    2014-04-01

    Full Text Available Background: chronic adenoiditis, which causes the greater number of elective major surgeries in children, is a common disease in Cuba. Objectives to describe the clinical and epidemiological characteristics of chronic adenoiditis in children. Methods: a descriptive study with non-probability sampling was conducted in 98 children with chronic adenoiditis treated at the University Pediatric Hospital of Central Havana, between September 2009 and July 2011. The variables analyzed were age, sex, symptoms, signs and main clinical manifestations, personal medical history, family history, and major environmental and social risk factors. A survey was conducted to identify risk factors. Statistical analysis such as: the mean, relative frequency and frequency tables were performed. Results: highest morbidity was observed in children aged 1 to 9 years. The main features of the disease were nasal obstruction, dental malocclusion, mouth breathing and respiratory infection. The most common risk factors were attendance to day-care centers and exposure to cigarette smoke. Personal and family history of asthma and respiratory allergies was the most frequently found. Conclusion: chronic adenoiditis in pediatric patients is multifactorial in origin, and tends to decrease in the child population older than nine years.

  4. Un lymphangiome kystique rétropéritonéal révélé par des coliques néphrétiques

    Science.gov (United States)

    El anzaoui, Jihad; Ghoundale, Omar; Touiti, Driss; El barni, Rachid; Mejdane, Abdelhadi; Fihri, Jawad Fassi; Lahkim, Mohammed; Achour, Abdsamad

    2015-01-01

    Résumé Le lymphangiome kystique (LK) est une tumeur rare des voies lymphatiques caractérisée par son évolution bénigne. La fréquence de la localisation rétropéritonéale est controversée. La découverte se fait le plus souvent dès l’enfance. L’évolution de la maladie peut être marquée par des complications graves, notamment compressives. Nous faisons état de l’observation médicale d’une femme de 30 ans chez qui l’on a découvert, à la suite de l’apparition de coliques néphrétiques récidivantes, un LK énorme occupant tout l’espace rétropéritonéal droit. Le diagnostic a été évoqué par l’urotomodensitométrie et confirmé par l’histologie. L’évolution après exérèse chirurgicale de la masse a été favorable, avec la disparition des coliques néphrétiques. PMID:25844099

  5. Production of cytokines by mononuclear cells of hypertrophic adenoids in children with otitis media with effusion.

    Science.gov (United States)

    Zelazowska-Rutkowska, Beata; Ilendo, Elzbieta; Skotnicka, Bozena; Wysocka, Jolanta; Kasprzycka, Edwina

    2012-01-01

    Hypertrophic adenoids with otitis media with effusion is a common infectious disease and present a serious otological problem in children. Cytokines, potent inflammatory mediators, play important role in the initiation of immunological response in otitis media. Adenoids excised due to hypertrophy with or without chronic otitis media with effusion were used to isolate mononuclear cells. Secretion of cytokines by non-stimulated and PHA-stimulated cells was determined by specific ELISAs. We found a significant increase in the production of IL-5 and TNF-α secreted by adenoidal cells of children with otitis media with effusion compared to group with hypertrophic adenoids. No differences were found in the secretion of IL-8, IL-6, and IL-10 between these two groups of patients. Our results suggest a difference between the immunological responses in the course of hypertrophic adenoids with otitis media as compared to hypertrophic adenoids.

  6. Concordance of Lateral Radiological Measurements and Quality of Life in Adenoid Hypertrophy

    OpenAIRE

    Ziya Salturk

    2013-01-01

    Aim: The aim of the study is to investigate the relationship between lateral radiological measurements and quality of life in children with adenoid hypertrophy. Material and Method: 22 children with adenoid hypertrophy were included in study. Survey obstructive sleep apnea 18 was used to assess the quality of life. Adenoid nasopharynx ratio was used to asses lateral radiological measurements. Results were analyzed statistically. Results: The mean value of obstructive sleep apnea 18 survey was...

  7. Asymmetric adenoid hypertrophy in a patient with ipsilateral rhinolithiasis: an overlooked entity?

    OpenAIRE

    Kazikdas, C; Gode, S; Demirci, M.

    2011-01-01

    The aim of this article is to present a rhinolithiasis patient with a significant asymmetric adenoid hypertrophy on the same side and to describe possible mechanisms for this clinical entity. Careful nasopharyngoscopy after removal of rhinolith is mandatory not to overlook significant adenoid hypertrophy which may interfere with patients’ symptoms. The role of paranasal CT scan in the diagnosis of an asymmetric adenoid hypertrophy in rhinolithiasis patients is also discussed.

  8. Relative etiological importance of adenoid hypertrophy versus sinusitis in children with persistent rhinorrhoea.

    Science.gov (United States)

    Maheswaran, S; Rupa, V; Ebenezer, Jareen; Manoharan, Anand; Irodi, Aparna

    2015-03-01

    Persistent rhinorrhoea is a common, yet often neglected, problem among Indian children. This study was designed to evaluate the relative etiological importance of adenoid hypertrophy versus sinusitis in children with persistent rhinorrhea. Additionally, the association between S. pneumoniae colonization and adenoid hypertrophy was studied. Children aged 1-14 years with persistent rhinorrhea underwent clinical evaluation, rigid nasal endoscopy and xrays of the nasopharynx and paranasal sinuses to ascertain the presence of adenoid hypertrophy and sinusitis using standard criteria. Nasopharyngeal swabbing to ascertain the presence of nasopharyngeal colonization with S. pneumoniae was also performed. Adenoid hypertrophy was more consistently associated with persistent rhinorrhea than sinusitis (p adenoid hypertrophy and sinusitis occurred in 57 %. S. pneumoniae was cultured in only 29 % of children. Up to 47 % of patients had features of nasal allergy. There was no association between S. pneumoniae colonization and adenoid hypertrophy (p = 0.1). Adenoid hypertrophy is an important cause of persistent rhinorrhea in children. Measures to evaluate for and treat adenoid hypertrophy should be instituted early to alleviate the problem of persistent rhinorrhoea in children. S. pneumoniae colonization of the nasopharynx is not a major etiological factor for persistent rhinorrhoea in these children. Nasal allergy may be a cause of adenoid hypertrophy in roughly half the children.

  9. Primary tuberculosis of the adenoids in an 11-year-old male presenting with hearing loss: a case report.

    Science.gov (United States)

    Taghipour-Zahir, S; Baradaranfar, M H; Zolfaghari, A A

    2013-04-01

    Hypertrophy of adenoids is usually caused by repeated throat infections, especially viral and bacterial infections, that in microscopic examination reveal reactive lymphoid follicular hyperplasia. Herein, we present an 11-year-old boy who developed hearing loss in his left ear three months before admission, and in direct examination the adenoids were hypertrophied. Histopathological study of the resected adenoid revealed caseating granulomatous inflammation. Based on histopathological and clinical findings, primary tuberculosis of adenoids was suggested which was confirmed by PCR.

  10. [An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].

    Science.gov (United States)

    Ren, Jianjun; Zhao, Yu; Ren, Xue

    2015-08-01

    Adenoid hypertrophy is a disease that mostly occurs among children of 3-5 years old. It is caused by repeated inflammation and infection of nasopharynx and its adjoin parts, or the adenoid itself, which will finally leads to pathological hyperplasia of adenoid. With so much information we have acquired about this disease, its specific mechanism remains unknown. In recent years, some researches have indicated that adenoid hypertrophy may have something to do with extra-gastroesophageal reflux, in which pepsin plays a very important role, and pepsin will do a series of pathological damages to the upper airway as it reaches the upper respiratory tract. Based on relative domestic and foreign literature, this paper attempts to make a review about the relationship between gastroesophageal reflux and adenoid hypertrophy.

  11. Concordance of Lateral Radiological Measurements and Quality of Life in Adenoid Hypertrophy

    Directory of Open Access Journals (Sweden)

    Ziya Salturk

    2013-10-01

    Full Text Available Aim: The aim of the study is to investigate the relationship between lateral radiological measurements and quality of life in children with adenoid hypertrophy. Material and Method: 22 children with adenoid hypertrophy were included in study. Survey obstructive sleep apnea 18 was used to assess the quality of life. Adenoid nasopharynx ratio was used to asses lateral radiological measurements. Results were analyzed statistically. Results: The mean value of obstructive sleep apnea 18 survey was 77.81(SD: 15.57 and the mean value of adenoid nasopharynx ratio was 0.70(SD:0.08. Spearmen correlation coefficient was calculated as 0.81. Discussion: The results of obstructive sleep apnea 18 and adenoid nasopharynx ratio was correlated.

  12. Prevalence of human papillomavirus and Epstein-Barr virus DNA in Chinese children with tonsillar and/or adenoidal hypertrophy.

    Science.gov (United States)

    Xue, Xiao-cheng; Chen, Xiao-ping; Yao, Wen-hao; Zhang, Yi; Sun, Guang-bin; Tan, Xue-jun

    2014-06-01

    Tonsillar and adenoidal hypertrophy are prevalent otolaryngologic disorders in children, but their pathogenesis is largely unknown. The presence of human papillomavirus (HPV) and Epstein-Barr virus (EBV) DNA in 146 tonsil and/or adenoid tissue specimens from 104 Chinese children with tonsillar and/or adenoidal hypertrophy were screened using flow-through hybridization gene-chip technology and real-time fluorescence-based quantitative PCR. Then, the relationships between the prevalence of the viruses and other clinical characteristics of tonsillar and/or adenoidal hypertrophy were analyzed. No patient had HPV DNA. EBV DNA was detected in 19/42 (45.2%) tonsil tissues and 72/104 (69.2%) adenoid tissue specimens (P hypertrophy. Adenoid tissues might more susceptible than tonsil tissues to EBV infection. In addition, EBV infection did not aggravate snoring in patients with tonsillar and/or adenoidal hypertrophy.

  13. Role of adenoid biofilm in chronic otitis media with effusion in children.

    Science.gov (United States)

    Saafan, Magdy Eisa; Ibrahim, Wesam Salah; Tomoum, Mohamed Osama

    2013-09-01

    To study the extent of surface adenoid biofilm and to evaluate its role in the pathogenesis of chronic otitis media with effusion (COME) in children. The study was carried out on 100 children between 3 and 14 years of age, who were divided into two groups. The first group (50 children) had otitis media with effusion associated with adenoid hypertrophy, whereas the second group (50 children) had adenoid hypertrophy without middle ear effusion. Adenoidectomy with ventilation tube insertion was done for group 1 cases, whereas, only Adenoidectomy was done for group 2 cases. Microbiological study, Scanning electron microscope and multiplex- PCR were done for suspected adenoid biofilms and specimens from middle ear effusion. Adenoids removed from children with COME had higher grade biofilm formation (74 %) than the second group (42 %). No correlation was found between adenoid size and biofilm formation. Culture of adenoid tissue in group 1 patients was positive in 52 % of cases compared to 96 % by PCR, while in group 2 culture of adenoid tissue was positive in 38 % compared to 48 % by PCR. Culture of middle ear fluid was positive in 32 % of cases only compared to 80 % by PCR. A positive correlation was found between results of bacterial biofilm visualized by SEM and bacteria detected and identified by PCR technique. On the other hand, no correlation was found between results of bacterial biofilm visualized by SEM and bacteria detected by culture. The size of the adenoid is not the main determinant factor in OME pathogenesis but the degree of bacterial colonization is much more important. Adenoids in COME may act as a reservoir of chronic infection rather than causing mechanical Eustachian obstruction. Higher grade biofilm formation was found in cases with middle ear effusion than those with adenoid hypertrophy only. These findings support the hypothesis that there would be an association between adenoidal biofilm formation and COME. This study focused on the value of PCR

  14. The Association Between Adenoid Hypertrophy and Enuresis in Children

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    Neshat

    2016-02-01

    Full Text Available Background Considering that enuresis is a common health problem among Iranian children, identifying the frequency of enuresis among children with adenoid hypertrophy (AH and its related factors could help us design appropriate management plans as well as preventative and interventional studies. Objectives We aimed to evaluate the prevalence of enuresis among children with AH and its associations with different characteristics of the disease. Patients and Methods This study was designed as a cross-sectional study. Children aged 5 - 12 years diagnosed with adenoid hypertrophy and as well as a group of normal children were studied (2010 - 2011 in Shariati hospital. The prevalence of enuresis was determined and compared in the two groups. The frequencies of different symptoms related to AH were compared in AH patients with and without enuresis. Results During this study, children with (n = 60 and without (n = 60 adenoid hypertrophy were investigated. The prevalence of enuresis was significantly higher in patients with AH compared with the control group (40% vs. 15%, P = 0.004, OR = 8.19. Enuresis was more prevalent among patients with AH who had a severe form of the disease, the signs of which are obstructive sleep apnea (OSA, growth impairment, and irritability (P < 0.05. Conclusions The results of our study indicated that enuresis was a common health problem among children with AH and it is associated with some symptoms of AH such as OSA, growth retardation and irritability. Using these findings as baseline data, we could determine the appropriate treatment approach for improving the course of the disease as well as the quality of the affected patients’ lives.

  15. Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses

    DEFF Research Database (Denmark)

    Amit, Moran; Binenbaum, Yoav; Sharma, Kanika;

    2013-01-01

    Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants......%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors...... of outcome (p sinuses, whereas perineural invasion is not. Adjuvant treatment apparently...

  16. Tracheal adenoid cystic carcinoma masquerading asthma: A case report

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    Kurul Cuneyt

    2004-10-01

    Full Text Available Abstract Background Tracheal tumors are often misdiagnosed as asthma and are treated with inhaled steroids and bronchodilators without resolution. Case Presentation Here, a patient with tracheal adenoid cystic carcinoma who had been previously diagnosed with difficult asthma was reported. The possibility of the presence of localized airway obstruction was raised when the flow-volume curve suggesting fixed airway obstruction, was obtained. Conclusion The presenting case report emphasizes the fact that not all wheezes are asthma. It is critical to bear in mind that if a patient does not respond to appropriate anti-asthma therapy, localized obstructions should be ruled out before establishing the diagnosis of asthma.

  17. Adenoid cystic carcinoma of the lacrimal sac: case report

    Directory of Open Access Journals (Sweden)

    Antonio Ramos

    Full Text Available ABSTRACT Lacrimal sac tumors are rare with a clinical presentation that typically includes obstruction of the lacrimal drainage system and epiphora as the most frequent symptom. Cribriform adenoid cystic carcinoma (ACC is the most common malignant epithelial tumor of the lacrimal gland and minor salivary glands; however, its occurrence in the lacrimal drainage apparatus is extremely rare. Given the rarity of ACC, definitive diagnosis is almost invariably late conferring a poor prognosis. Herein we report the case of a 41-year-old woman with primary ACC of the lacrimal sac and describe the ophthalmological examination, diagnosis, and multidisciplinary treatment of this rare type of tumor.

  18. Prevalence of the Helicobacter pylori in the tonsils and adenoids

    Directory of Open Access Journals (Sweden)

    Tuba Bayindir

    2015-06-01

    Full Text Available INTRODUCTION: There is an ongoing debate about the existence and effects of Helicobacter pylori (Hp in adenotonsillar tissue. OBJECTIVE: A clinical study was conducted to assess the existence of Hp in the adenoid and/or adenotonsillar tissues, which were surgically excised due to chronic adenotonsillitis. METHODS: Phosphoglucosamine mutase gene for the detection of Hp and cytotoxin-associated gene as virulence gene were examined in 84 adenotonsillar tissues obtained from 64 patients and patients' serum by using polymerase chain reaction. RESULTS: Hp IgG was detected in 57 (89% patients' serum. A total of seven tissue samples from 64 patients (10.9% were found positive for Hp DNA, of which five were adenoids and two were tonsil tissues. All polymerase chain reaction positive samples were also positive for the cytotoxin-associated gene, which is a virulence determinant for the organism. CONCLUSION: This study suggests that children are exposed to Hp at an early age of their life in this province. Hp may have a role in the pathogenesis of chronic adenotonsillitis, especially in endemic areas.

  19. Adenoid cystic carcinoma of the minor salivary glands

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    Kwon, Kyung Yun; Lee, Kyung Ho; Kim, Dong Youn; Choi, Karp Shik [Dept. of Dental Radiology, College of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    1997-02-15

    Adenoid cystic carcinoma is a malignant salivary gland tumor with typical histologic patterns. The majority of the se tumors occurs in the minor salivary glands, especially mucosa of the hard palate. The authors experienced the patients, who complained the tumor-like soft tissue masses on the palatal and mouth floor area. After careful analysis of clinical, radiological and histopathological findings, we diagnosed them as adenoid cystic carcinomas in the minor salivary glands, obtained results were as follows : 1. Main clinical symptoms were a slow growing soft tissue mass with normal intact mucosa on the palatal area, and soft tissue mass with mild pain on the mouth floor area. 2. In the radiographic examinations, soft tissue masses were observed with invasion to adjacent structures, and moderate defined, heterogeneous soft tissue mass with enhanced margin, respectively. 3. In the histopathologic examinations, dark-stained, small uniform ballad's cells in the hyaline or fibrous stroma were observed as solid and cribriform patterns, respectively.

  20. Radiographic adenoid evaluation: proposal of an objective parameter

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    Murilo Fernando Neuppmann Feres

    2014-04-01

    Full Text Available Objective The objective of the present study was to evaluate current radiographic parameters designed to investigate adenoid hypertrophy and nasopharyngeal obstruction, and to present an alternative radiographic assessment method. Materials and Methods In order to do so, children (4 to14 years old who presented with nasal obstruction or oral breathing complaints were submitted to cavum radiographic examination. One hundred and twenty records were evaluated according to quantitative radiographic parameters, and data were correlated with a gold-standard videonasopharyngoscopic study, in relation to the percentage of choanal obstruction. Subsequently, a regression analysis was performed in order to create an original model so the percentage of the choanal obstruction could be predicted. Results The quantitative parameters demonstrated moderate, if not weak correlation with the real percentage of choanal obstruction. The regression model (110.119*A/N demonstrated a satisfactory ability to “predict” the actual percentage of choanal obstruction. Conclusion Since current adenoid quantitative radiographic parameters present limitations, the model presented by the present study might be considered as an alternative assessment method in cases where videonasopharyngoscopic evaluation is unavailable.

  1. Hypertrophic adenoids in patients with nasopharyngeal carcinoma:appearance at magnetic resonance imaging before and after treatment

    Institute of Scientific and Technical Information of China (English)

    Yao-Pan Wu; Pei-Qiang Cai; Li Tian; Jie-Hua Xu; Richard Alan Mitteer Jr; Yi Fan; Zhenfeng Zhang

    2015-01-01

    Introduction:Patients with nasopharyngeal carcinoma (NPC) sporadically develop abnormal adenoids. Nasopharyngeal adenoids are usually included in the gross tumor volume (GTV) but may have different therapeutic responses than tumor tissue. Therefore, distinguishing adenoids from tumor tissue may be required for precise and efficient chemoradiotherapy and radiotherapy. We characterized nasopharyngeal adenoids and investigated the therapeutic responses of NPC and nasopharyngeal adenoids using magnetic resonance imaging (MRI). Methods:MRI data from 40 NPC patients with a coexisting adenoid mass before and after treatment were analyzed. The features of the adenoid masses, including location, striped appearance, size, interface, symmetry/asymmetry, and cysts, were evaluated. Treatment response were scored according to the World Health Organization guidelines. Results:A striped appearance was observed in 36 cases before treatment and in all cases after treatment. In these 36 cases, the average GTVs including and excluding the uninvolved adenoids were 19.8 cm3 and 14.8 cm3, respectively. The average percentage change after excluding the uninvolved adenoids from the GTV was 31.0%. Stable disease in the adenoids was identified in 27 (96.4%) of 28 patients after neoadjuvant chemotherapy, while NPC clearly regressed. Partial adenoid responses were identified in 33 (82.5%) of 40 patients at 3 months after chemoradiotherapy or radiotherapy, whereas complete tumor responses were achieved in all patients. Six months after treatment, the adenoids continued to atrophy but did not disappear, and tumor recurrence was not found. Conclusions:Nasopharyngeal adenoids and carcinoma tissue in NPC patients can be distinguished by using MRI and have different responses to chemoradiotherapy and radiotherapy. These findings contribute to better delineating the GTV of NPC, based on which spatially optimized strategies can be developed to render precise and efficient chemoradiotherapy and

  2. Craniofacial skeletal pattern: is it really correlated with the degree of adenoid obstruction?

    Directory of Open Access Journals (Sweden)

    Murilo Fernando Neuppmann Feres

    2015-08-01

    Full Text Available OBJECTIVE: The aim of this study was to compare the cephalometric pattern of children with and without adenoid obstruction.METHODS: The sample comprised 100 children aged between four and 14 years old, both males and females, subjected to cephalometric examination for sagittal and vertical skeletal analysis. The sample also underwent nasofiberendoscopic examination intended to objectively assess the degree of adenoid obstruction.RESULTS: The individuals presented tendencies towards vertical craniofacial growth, convex profile and mandibular retrusion. However, there were no differences between obstructive and non-obstructive patients concerning all cephalometric variables. Correlations between skeletal parameters and the percentage of adenoid obstruction were either low or not significant.CONCLUSIONS: Results suggest that specific craniofacial patterns, such as Class II and hyperdivergency, might not be associated with adenoid hypertrophy.

  3. TREATMENT AND PREVENTION OF ADENOIDITIS WITH BACTERIAL LYSATES IN SICKLY CHILDREN

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    S. I. Tyurkina

    2013-01-01

    Full Text Available We carried out the analysis of researches devoted to the treatment of children with chronic adenoiditis and hypertrophy of adenoid vegetations. We proved that the usage of topic immunomodulator IRS19 incombination with etiotropic treatment allows to sanate lymphoid tissues in nasopharynx effectively and to preserve its continuity as an important organ supplying unspecific and specific protection of the child’s organism.

  4. Relative Etiological Importance of Adenoid Hypertrophy Versus Sinusitis in Children with Persistent Rhinorrhoea

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    Maheswaran, S; Rupa, V.; Ebenezer, Jareen; Manoharan, Anand; Irodi, Aparna

    2014-01-01

    Persistent rhinorrhoea is a common, yet often neglected, problem among Indian children. This study was designed to evaluate the relative etiological importance of adenoid hypertrophy versus sinusitis in children with persistent rhinorrhea. Additionally, the association between S. pneumoniae colonization and adenoid hypertrophy was studied. Children aged 1–14 years with persistent rhinorrhea underwent clinical evaluation, rigid nasal endoscopy and xrays of the nasopharynx and paranasal sinuses...

  5. Métastase cérébrale d'un carcinome du col utérin

    Science.gov (United States)

    Chekrine, Tarik; Hassouni, Abdesalam; Jouhadi, Hassan; Sahraoui, Souha; Bouchbika, Zineb; Taleb, Amina; Benchakroun, Nadia; Tawfiq, Nezha; Benider, Abdellatif

    2013-01-01

    Les métastases cérébrales des cancers du col de l′utérus sont extrêmement rares. Elles sont généralement supra-tentorielles, survenant à un stade avancé de la maladie et dans un cadre de néoplasie polymétastatique. La tumeur primitive est le plus souvent un carcinome épidermoïde peu différencié. Leur pronostic reste sombre malgré toutes les options thérapeutiques. Vu la rareté de cet événement et le peu de cas publiés dans la littérature, nous rapportons l'observation clinique d'une jeune patiente de 44 ans, opérée pour un carcinome du col utérin et qui présente 14 mois plus tard des métastases cérébrales sus et sous tentorielles associées à des métastases ganglionnaires lombo-aortique, médiastinale et sus-claviculaire. Elle a bénéficié d'un traitement palliatif associant une chimiothérapie et une radiothérapie pan encéphalique. Devant l'altération rapide de l'état général, la patiente a été mise sous un traitement symptomatique et des soins de support. PMID:23717727

  6. Impact of passive smoke and/or atopy on adenoid immunoglobulin production in children.

    Science.gov (United States)

    Tagliacarne, Sara Carlotta; Valsecchi, Chiara; Castellazzi, Anna Maria; Licari, Amelia; Klersy, Catherine; Montagna, Lorenza; Castagnoli, Riccardo; Benazzo, Marco; Ciprandi, Giorgio; Marseglia, Gian Luigi

    2015-06-01

    The adenoids are exposed to a wide number and variety of microbes, environmental pollutants, and food antigens. Atopy and passive smoke may significantly affect immune responses, mainly in children. The aim of the present study was to investigate whether passive exposure to tobacco smoke and/or atopy could affect immunoglobulin production by adenoidal lymphocytes in a cohort of children presenting with adenoid hypertrophy. A total of 277 children (151 males and 126 females; median age 5.5 years), with adenoidal hypertrophy requiring adenoidectomy and or adeno-tonsillectomy, were consecutively enrolled in the study. Adenoid mononuclear cells were in vitro stimulated with LPS or CpG. When considering both the presence of smoke exposure and atopy, we observed that the CpG-induced decrease in IgA and IgM production was significantly associated with this combination of risk factors. In the T-independent immunoglobulin production assay we found a positive association between the two risk factors and IgA and IgM production. In particular, the presence of both risk factors, showed a significant increase in IgA and IgM production after stimulation. In conclusion, this is the first study that investigated the in vitro adenoidal B cell response after different stimuli in children, also evaluating possible exposure to passive smoke and/or an atopic condition.

  7. Tympanometric Findings among Children with Adenoid Hypertrophy in Port Harcourt, Nigeria

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    Chibuike Nwosu

    2016-01-01

    Full Text Available Introduction. Adenoid hypertrophy (AH is a common childhood disorder. Adenoid plays a significant role in the pathogenesis of otitis media with effusion (OME. The aim of this study is to critically appraise the tympanometric finding among children with adenoid hypertrophy in Port Harcourt, Nigeria. Methodology. A Prospective, controlled study carried out among newly diagnosed cases of adenoid hypertrophy at the ENT clinic of the UPTH, between November 2014 and June 2015. Tympanometry was done on each child and each ear was considerably studied as a single entity. Types B and C tympanograms were used as indicators of OME. Data was collected and analyzed using SPSS version 20. Results. Sixty-eight cases of adenoid hypertrophy were seen within the study period and 136 ears were studied. Forty (29.4% ears had type B tympanogram, while 36 (26.5% ears had type C. The incidence of OME was 55.9%; there were 12 (17.6% unilateral OME, while bilateral OME was 32 (47.1%. Grade 3 AH was prevalent and was statistically significant with the OME. Conclusion. This study had shown adenoidal hypertrophy as a significant risk factor for OME in children. There was more bilateral OME than unilateral. The more severe grade of AH was more prevalent and it was shown to be statistically significant with OME, thus being a significant risk factor for OME in children. This establishes the need for prompt hearing evaluation and management.

  8. Carcinome épidermoïde Primitif de la Prostate: A propos d’un cas et revue de la littérature

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    A. Bahloul

    2016-12-01

    Full Text Available Le cancer de la prostate est la tumeur maligne la plus fréquente chez l’homme. La grande majorité des tumeurs de la prostate est représentée par l’adénocarcinome prostatique (jusqu’à 95%. Le carcinome épidermoïde primitif est très rare et ne représente que 0,5% à 1% des carcinomes prostatiques. Jusqu’à 2014 seulement 24 cas ont été décrits dans la littérature. Nous rapportons un nouveau cas de carcinome épidermoide primitif de la prostate chez un jeune âgé de 48 ans diagnostiqué à un stade métastatique. Malgré une chimiothérapie à base de Cisplatine et Métoxantrone, le décès est survenu 2 mois après le diagnostic. A travers cette observation et une revue de la littérature, nous discutons les différents aspects cliniques, histologiques, thérapeutiques et pronostiques de cette tumeur.

  9. La place de l'imagerie par résonance magnétique dans le carcinome lobulaire du sein

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    Bouzoubaa, Wail; Laadioui, Meryem; Alaoui, Fatime Zahra Fdili; Jayi, Sofia; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2014-01-01

    Le carcinome lobulaire reste une entité histologique peu fréquente du cancer du sein, toute fois la place qu'occupe le cancer du sein actuellement dans la cancérologie féminine, justifie la connaissance des particularités de ce type de cancer mammaire. Le diagnostic paraclinique est basée sur le couple écho-mammographie a la recherche de multifocalité, multicentricité ou bilatéralité, d'où l'intérêt de l'IRM qui est la technique la plus sensible pour la mise en évidence de ces lésions et qui est devenue un examen de pratique courante dans le carcinome lobulaire du sein. Par le présent travail, et sous la lumière de la revue de la littérature, nous allons essayer de dégager les aspects épidémiologiques, cliniques, et paracliniques, du carcinome lobulaire du sein, et insister sur les indications et l'intérêt de l'IRM dans la prise en charge de ce type histologique. PMID:25368710

  10. Intraosseous adenoid cystic carcinoma of maxilla: A rare case report

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    Prasannasrinivas Suresh Deshpande

    2013-01-01

    Full Text Available Adenoid cystic carcinoma (ACC accounts for approximately 6-10% of all salivary gland tumors. Palatal minor salivary glands, parotid, and sub-mandibular glands are usually affected. Rarely, these lesions arising intraosseously have been reported. Mandible is commonly involved than maxilla. The present case is a giant ACC involving the right maxilla. A thorough clinical and radiographic evaluation was performed to assess the involvement of surrounding vital structures along with a meticulous metastatic work-up. Computed tomography showed a giant lesion in maxilla encroaching the left nasal fossa, antrum, buccal space, and oral cavity. No metastasis was noted. Histological evaluation from multiple sites showed both cribriform and solid patterns. Radiotherapy was given as patient did not comply for surgery. Though central ACC is extremely rare, especially in maxilla, it should be included in the differentials for lesions in maxilla. A prompt diagnosis with treatment and long-term follow-up is advised in such cases.

  11. Adenoid Cystic Carcinoma Mimicking an Oroantral Fistula: A Case Report

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    Monteiro, Bárbara Vanessa de Brito; Grempel, Rafael Grotta; Gomes, Daliana Queiroga de Castro; Godoy, Gustavo Pina; Miguel, Márcia Cristina da Costa

    2013-01-01

    Introduction Adenoid cystic carcinoma (ACC) is one of the most frequent malignant salivary gland tumors, which commonly affects the minor salivary glands of the mouth and is rare in the nose and paranasal sinuses. In the maxillary sinus, ACC can mimic inflammatory diseases and has a poor prognosis. Objective To report a case of a 50-year-old man with ACC of the maxillary sinus whose clinical findings in the alveolar ridge mimicked an oroantral fistula. Case Report An excisional biopsy was performed and histopathologic analysis revealed ACC. Lung metastases and residual tumor in the maxillary sinus were detected by imaging methods. In view of the poor general health of the patient, no new surgical intervention was performed and he was only treated by radiotherapy and follow-up. Conclusion Although rare in the maxillary sinus, ACC should be included in the differential diagnosis of lesions affecting this site. PMID:25992095

  12. Primary tuberculosis of nasopharynx (adenoid)- A rare presentation

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    Chandrakant Patil; Rashmi Kharat Patil; Prasad Deshmukh; Jyotirmoy Biswas; Bassin John

    2013-01-01

    Tuberculosis has global presence and no part of human body is immune to it, most frequent site beings lungs.Nasopharyngeal tuberculosis is a rare type of extrapulmonary tuberculosis comprising only less than1% of tuberculosis found in the upper respiratory tract.The authors are presenting here a case of primary tuberculousis affecting the nasopharynx (adenoids) which is one of the rare differential diagnosis of nasopharyngeal mass.Isolated nasopharyngeal tuberculosis is a rare condition even in the endemic areas.In literature there are varied clinical presentations of nasopharyngeal tuberculosis.Tuberculosis should be one of the differential diagnosis of nasopharyngeal lesion.Biopsy and histologic study should be performed in every patient to avoid misdiagnosis.When treated properly, nasopharyngeal tuberculosis carries a excellent prognosis,and complete resolution of disease is the rule.

  13. Adenoid Cystic Carcinoma Mimicking an Oroantral Fistula: A Case Report

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    Monteiro, Bárbara Vanessa de Brito

    2014-01-01

    Full Text Available Introduction Adenoid cystic carcinoma (ACC is one of the most frequent malignant salivary gland tumors, which commonly affects the minor salivary glands of the mouth and is rare in the nose and paranasal sinuses. In the maxillary sinus, ACC can mimic inflammatory diseases and has a poor prognosis. Objective To report a case of a 50-year-old man with ACC of the maxillary sinus whose clinical findings in the alveolar ridge mimicked an oroantral fistula. Case Report An excisional biopsy was performed and histopathologic analysis revealed ACC. Lung metastases and residual tumor in the maxillary sinus were detected by imaging methods. In view of the poor general health of the patient, no new surgical intervention was performed and he was only treated by radiotherapy and follow-up. Conclusion Although rare in the maxillary sinus, ACC should be included in the differential diagnosis of lesions affecting this site.

  14. Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis

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    Cheshil Dixit

    2016-01-01

    We present the case of a child with chronic adenoiditis caused by a PspK+ NESp. We tested the pneumococcal isolate, designated C144.66, for antimicrobial resistance, the presence of the pspK gene and the expression of PspK. Sequence typing and genome sequencing were performed. C144.66 was found to be resistant to erythromycin and displayed intermediate resistance to penicillin and trimethoprim/sulfamethoxazole. C144.66 has the pspK gene in place of the capsule locus. Additionally, PspK expression was confirmed by flow cytometry. NESp are a growing concern as an emerging human pathogen, as current pneumococcal vaccines do not confer immunity against them. An inability to vaccinate against NESp may result in increased carriage and associated pathology.

  15. Evaluation of the relation between adenoids hypertrophy and cranial base angles

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    Dalili Z

    2006-07-01

    Full Text Available Background and Aim: Adenoids are normally large in children and their size starts to reduce during adolescence. Hypertrophic adenoids could be associated with allergic reactions. Enlarged adenoids result in nasal breathing difficulties and the child is forced to switch to mouth breathing. Airway obstruction causes postural alterations of jaw, tongue and head, and due to persistent obstruction, patient’s appearance changes to adenoid face. Evaluation of nasopharyngeal space in lateral cephalometic view is a simple and repeatable method for determination of the size and shape of adenoids and nasopharyngeal space which can provide a simple measurement of nasopharyngeal obstruction. The roof of nasopharyngeal space is covered by the sphenoid bone. Thus changes of nasorespiratory resistance by hypertrophic adenoids may affect the cranial base angles. In this study, the relationship between adenoid hypertrophy and cranial base angles was investigated. Materials and Methods: In this descriptive-analytic study, lateral cephalometric views of 7 to 14 y/o patients from the files of orthodontic centers in Rasht city were selected. The radiographs with proper resolution were separated for this research. Adenoid to nasorespiratory ratio (A/N Ratio was determined by Fujioka method and categorized in three groups: A (A/N 0.8, B (0.5adenoid hypertrophy (A and B groups was observed in 66% of cases whereas 34% were normal. The frequency of narrow, normal and wide cranial base angles

  16. 16S rRNA survey revealed complex bacterial communities and evidence of bacterial interference on human adenoids.

    Science.gov (United States)

    Ren, Tiantian; Glatt, Dominique Ulrike; Nguyen, Tam Nhu; Allen, Emma Kaitlynn; Early, Stephen V; Sale, Michele; Winther, Birgit; Wu, Martin

    2013-02-01

    Adenoid microbiota plays an important role in the development of various infectious and non-infectious diseases of the upper airways, such as otitis media, adenotonsillitis, rhinosinusitis and adenoid hypertrophy. Studies have suggested that adenoids could act as a potential reservoir of opportunistic pathogens. However, previous bacterial surveys of adenoids were mainly culture based and therefore might only provide an incomplete and potentially biased assessment of the microbial diversity. To develop an in-depth and comprehensive understanding of the adenoid microbial communities and test the 'pathogen reservoir hypothesis', we carried out a 16S rRNA based, culture-independent survey of bacterial communities on 67 human adenoids removed by surgery. Our survey revealed highly diverse adenoid bacterial communities distinct from those of other body habitats. Despite large interpersonal variations, adenoid microbiota shared a core set of taxa and can be classified into at least five major types based on its bacterial species composition. Our results support the 'pathogen reservoir hypothesis' as we found common pathogens of otitis media to be both prevalent and abundant. Co-occurrence analyses revealed evidence consistent with the bacterial interference theory in that multiple common pathogens showed 'non-coexistence' relationships with non-pathogenic members of the commensal microflora.

  17. Radiologic evaluation of adenoids and tonsils in children with obstructive sleep apnea: Plain films and fluoroscopy

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    Kreplick Fernbach, S.; Brouillette, T.; Riggs, T.W.; Hunt, C.E.

    1983-07-01

    Twenty-six children with obstructive sleep apnea were evaluated by lateral neck radiographs during wakefulness, and by polygraphic monitoring and upper airway fluoreoscopy during natural sleep. Children with craniofacial abnormalities, palatal surgery, and central nervous system disease were excluded from the study. Moderate or marked enlargement of tonsils and adenoids was noted on lateral neck radiographs of 18 of 26 patients. An objective measure of adenoidal enlargement, the adenoidal-nasopharyngeal ratio, correlated well with subjective judgment of adenoidal size but was not generally more useful than subjective estimation. Upper airway fluroescopy demonstrated the site and mechanism of obstruction in all patients. Because all children with moderate to marked adenotonsillar enlargement demonstrated obstruction at the adenoidal or tonsillar level on fluoroscopy, we now screen children with suspected sleep apnea with lateral airway radiographs and polysomnography. Fluoroscopy is reserved for children with mild adenotosillar enlargement, craniofacial dysplasia, prior cleft palate repair, or neuromuscular disorders. These results suggest that the pathogenesis of obstuctive sleep apnea in children involve anatomic factors which narrow the upper airway, sleep-related hypotonia of pharyngeal dilator musculature, and compensatory mechanisms to prevent or alleviate asphyxia.

  18. Adenoid cystic carcinoma of the lacrimal gland metastasising to the liver: report of a case

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    Pearce Neil W

    2006-09-01

    Full Text Available Abstract Background Adenoid Cystic Carcinoma of the lacrimal gland is a rare tumour. Their aggressive behaviour, with a high-risk of local recurrence, and late distant spread of the tumour even after aggressive management has been reported. Metastasis to the liver is rare and when it occurs, it is usually part of widespread metastasis, and therefore surgical treatment is seldom considered. Case presentation We report a rare case of an isolated liver metastasis from a lacrimal gland adenoid cystic carcinoma 20 years after resection of the primary tumour. The patient presented with right upper quadrant pain radiating to the back and shortness of breath of 3 months duration. No local recurrence was detected during a 15 year follow-up with computerized tomography (CT of the head. Abdominal CT scan demonstrated a solitary liver tumour with no other primary source, and the bone scan was normal. The patient was treated with an extended right hemihepatectomy. The histology revealed a predominantly cribriform tumour with focal areas of basaloid type metastatic lacrimal gland adenoid cystic carcinoma. Conclusion This case illustrates the unpredictable behaviour of adenoid cystic carcinoma and the need for a life long follow up for these patients after treatment. The possibility of surgical resection for liver metastasis from adenoid cystic carcinoma should always be considered.

  19. The Role of Adenoid Mast Cells in the Pathogenesis of Secretory Otitis Media

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    M. Faruk Oktay

    2007-01-01

    Full Text Available To investigate the possible role of adenoid mast cells in the etiology of secretory otitis media. Between 2001-2002, 25 patients with chronic adenoitis and chronic secretory otitis media and 25 patients with isolated adenoid hypertrophy were included to the study. Adenoidectomy performed to the all patients under general anesthesia. Adenoidectomy specimens were evaluated under the light microscopy and the number of mast cells were calculated for each patient. The number of mast cells were compared between two groups. The number of mast cells were between 4-84 in the otitis media with effusion and adenoid hypertrophy group (median:52, however it was between 2-63 (median: 23 in the isolated adenoid hypertrophy group. When comparing the two groups using Mann-Withney U test, the number of mast cells found to be significantly higher in the chronic secretory otitis media group (p<0.001.Based on our findings there is a relationship between increased adenoid mast cells and otitis media with effusion and these cells may have a possible role in the etiology of chronic secretory otitis media.

  20. Validity of acoustic rhinometry in the evaluation of patients with adenoid hypertrophy.

    Science.gov (United States)

    Uyar, Melek; Tekat, Atilla; Koyuncu, Mehmet; Ünal, Recep; Şeşen, Teoman; Tanyeri, Yücel

    2014-07-01

    Reliability of acoustic rhinometry (AR) for preoperative diagnosis and decision of surgery in children with adenoid hypertrophy were investigated in this study. Fifty-five children who cannot tolerate nasal endoscopic examination were included. The AR was performed preoperatively and postoperatively 1 month later. The volume of distance between the 6th and 10th centimeters in rhinogram curve was calculated for evaluating the adenoid notch (AN) region. The volume of AN region was compared with each patient's volume of the adenoid tissue removed with adenoidectomy. Whereas the median adenoid specimen volume was 2.0 (1.0-2.0) cm3 in 23 patients with complaint of nasal obstruction, median AN volumes in the rhinogram curve was 2.3 (0.8-5.2) cm3. All children whose preoperative nasopharyngeal volume was 4.2 cm3 or less had increased volume in the area representing the nasopharynx on rhinogram. We found a statistically significant relationship between the AN and the adenoid specimen volume (P = 0.000, r = 0.797). The sensitivity and specificity were found as 61.2% and 95.8%, respectively. We concluded that the children whose preoperative nasopharyngeal volumes were measured as 4.2 cm3 or less by AR could benefit more from adenoidectomy.

  1. Expression of Th17 and Treg lymphocyte subsets in hypertrophied adenoids of children and its clinical significance.

    Science.gov (United States)

    Sade, Kobi; Fishman, Gadi; Kivity, Shmuel; DeRowe, Ari; Langier, Sheila

    2011-01-01

    Adenoid hypertrophy is the most common cause of upper airway obstruction and sleep-disordered breathing in children, yet its pathogenesis remains unclear. The identification of the novel helper T cell subsets, Th17 cells and regulatory T cells (Tregs) could provide new insight into our understanding of the mechanisms involved in the development of this condition. The purpose of this study is to evaluate the adenoidal lymphocyte subsets to describe the percentage of various lymphocyte subsets in hypertrophied adenoids and correlate them with symptom severity. Twenty consecutive children undergoing adenoidectomy were included, and lymphocytes were isolated from their adenoids. T cell subpopulations were detected by flow cytometry using a fluoresceinated monoclonal antibody directed against a number of cell markers (CD4+, CD8+, CD25+, FOXP3 IL17+, and others). We found a significant negative linear correlation between the Th17/Treg ratio and the patients' clinical scores (R = -0.71 p adenoid hypertrophy.

  2. Evaluation of MYB Promoter Methylation in Salivary Adenoid Cystic Carcinoma

    Science.gov (United States)

    Shao, Chunbo; Bai, Weiliang; Junn, Jacqueline C.; Uemura, Mamoru; Hennessey, Patrick T.; Zaboli, David; Sidransky, David; Califano, Joseph A.; Ha, Patrick K.

    2011-01-01

    Summary The transcription factor MYB was recently proposed to be a promising oncogene candidate in salivary gland adenoid cystic carcinoma (ACC). However, the up-regulation of MYB in ACC could not be explained solely by deletion of its 3′ end. It is widely accepted that the promoter methylation status can regulate the transcription of genes, especially in human cancers. Therefore, it is important to know whether MYB promoter demethylation could explain the over-expression of MYB in ACC. By using the Methprimer program, we identified nine CpG islands in the promoter of MYB. All of these CpG islands were located within the −864 to +2,082 nt region relative to the transcription start site of MYB. We then used bisulfite genomic sequencing to evaluate the methylation levels of the CpG islands of MYB in 18 primary ACC tumors, 13 normal salivary gland tissues and nine cancer cell lines. Using cell lines, we also determined the relative MYB expression levels and correlated these with the methylation levels. With bisulfite genomic sequencing, we found no detectable methylation in the CpG islands of MYB in either ACC or normal salivary gland tissues. There was a variable degree of MYB expression in the cell lines tested, but none of these cell lines demonstrated promoter methylation. Promoter hypomethylation does not appear to explain the differential expression of MYB in ACC. An alternative mechanism needs to be proposed for the transcriptional control of MYB in ACC. PMID:21324728

  3. Mean platelet volume levels in children with adenoid hypertrophy.

    Science.gov (United States)

    Kucur, Cuneyt; Kulekci, Semra; Zorlu, Aylin; Savran, Bircan; Oghan, Fatih; Yildirim, Nadir

    2014-01-01

    Adenoid hypertrophy (AH) is a common disorder in children, resulting in chronic nasal congestion. This chronic congestion should be evaluated carefully because it can lead to chronic upper airway obstruction. Many authors have suggested that increased nasal resistance to respiration may cause disturbances in the pulmonary ventilation and carry the risk of cardiopulmonary diseases. Mean platelet volume (MPV) is a marker of platelet function and is positively associated with indicators of platelet activity. Mean platelet volume is an indicator of larger and more reactive platelets and has been shown to be increased in patients with vascular disease, including peripheral, pulmonary, and coronary artery disease. Recently, MPV levels have also been shown to be increased in patients with severe obstructive sleep apnea, and marked nasal septal deviation. Moreover, increased MPV has also been shown to have a prognostic role in cardiovascular disease. We investigated whether MPV is higher in patients with AH and whether higher MPV levels can be reduced by adenoidectomy. To the best of our knowledge, this is the first study to investigate MPV in patients with AH. Our results suggest that MPV, a determinant of platelet activation, is elevated in patients with AH and adenoidectomy is an effective therapeutic measure in such patients. Increased platelet activation may be related to an increase of cardiopulmonary risk in patients with AH.

  4. Elective Neck Dissection in Patients With Head and Neck Adenoid Cystic Carcinoma

    DEFF Research Database (Denmark)

    Amit, Moran; Na'ara, Shorook; Sharma, Kanika;

    2015-01-01

    BACKGROUND: Adenoid cystic carcinoma (ACC) accounts for 3-5 % of all head and neck malignancies. Investigations of outcomes from elective neck dissection (END) for patients with ACC are sparse. This study aimed to assess the impact of END on the survival of patients with ACC. METHODS: This retros......BACKGROUND: Adenoid cystic carcinoma (ACC) accounts for 3-5 % of all head and neck malignancies. Investigations of outcomes from elective neck dissection (END) for patients with ACC are sparse. This study aimed to assess the impact of END on the survival of patients with ACC. METHODS...

  5. Cystic adenoid carcinoma of the external auditory meatus with mastoid involvement

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    Tinoco, Paulo

    2009-06-01

    Full Text Available Introduction: The cystic adenoid carcinoma (CAC in the external auditory meatus is rare and was originated in the ceruminous glands. It is manifested by otalgia in about 90% of the patients. Case Report: In this article we report the case of a patient with Cystic Adenoid Carcinoma of the external auditory meatus with mastoid involvement that presented peripheral facial paralysis. The treatment is essentially surgical, combined or not with postoperative radiotherapy. The factors of bad prognosis are the tumor expansion, facial nerve and middle ear invasion and lymph node affection, which diminish the survival in five years from 59% to 23%.

  6. [A case of carcinoma adenoides cysticum in the external auditory canal].

    Science.gov (United States)

    Soboczyński, R; Wojnowski, W

    2001-01-01

    The authors present a case of a woman aged 31 with carcinoma adenoides cysticum at external auditory canal. The tumor was surgically removed; after 9 month a recrudescence was ascertained but there were no metastasis to other organs. The tumor was once more surgically removed. Now it has been a year of observation and no renewal of neoplastic process was noticed.

  7. Nomograms for predicting survival and recurrence in patients with adenoid cystic carcinoma. An international collaborative study

    DEFF Research Database (Denmark)

    Ganly, Ian; Amit, Moran; Kou, Lei;

    2015-01-01

    BACKGROUND: Due to the rarity of adenoid cystic carcinoma (ACC), information on outcome is based upon small retrospective case series. The aim of our study was to create a large multiinstitutional international dataset of patients with ACC in order to design predictive nomograms for outcome. METH...

  8. The effect of hypertrophic adenoids and tonsils on the development of posterior crossbite and oral habits.

    Science.gov (United States)

    Oulis, C J; Vadiakas, G P; Ekonomides, J; Dratsa, J

    1994-01-01

    There are a number of studies in the literature, that associate nasopharyngeal airway obstruction, as a result of adenoid enlargement, to the development of skeletal and dental abnormalities. However, the etiologic role of hypertrophied adenoids and tonsils in developing an aberrant dentofacial growth is not clear, yet. The present investigation attempted to study the incidence of maxillary posterior crossbite and oral habits, in a sample of 120 children, that displayed hypertrophied adenoids with or without enlarged tonsils, and underwent adenoidectomy. An attempt was also made to relate the presence of crossbite to the severity of upper respiratory airway obstruction. The severity of airway obstruction was assessed using radiographic and surgical criteria. A lateral cephalometric radiograph was obtained and studied for each patient. Results indicated, that 47% of the children examined, had developed a posterior crossbite. The presence of crossbite was high in children with severe airway obstruction, particularly in those with hypertrophied adenoids and tonsils. On the contrary, most of the children with a posterior crossbite did not have a history of pacifier or finger sucking. It was also concluded, that the study of a lateral cephalometric radiograph can be a valuable diagnostic method in the evaluation of children with upper airway obstruction.

  9. Pulmonary artery stent for bronchial adenoid cystic carcinoma causing pulmonary artery stenosis

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    Smith, Corey Allister; Kotlyar, Eugene; Mellemkjaer, Soren;

    2014-01-01

    A 46-year-old woman presented with a 6-month history of dyspnea and weight loss on a background of previous pneumonectomy for bronchial adenoid cystic carcinoma 14 years beforehand. Several years prior to this presentation, she had developed left vocal cord palsy and a metastatic lesion...

  10. Microbiological Profile of Adenoid Hypertrophy Correlates to Clinical Diagnosis in Children

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    Anita Szalmás

    2013-01-01

    Full Text Available Objective. Adenoid hypertrophy is a common condition in childhood, which may be associated with recurring acute otitis media (RAOM, otitis media with effusion (OME, and obstructive sleep apnea syndrome (OSAS. These different clinical characteristics have some clinical overlap; however, they might be explained by distinct immunologic and infectious profiles and result in various histopathologic findings of adenoid specimens. Methods. A total of 59 children with adenoid hypertrophy undergoing adenoidectomy were studied. Three series of identical adenoid specimens were processed to hematoxylin-eosin (H.E. and Gram staining and to respiratory virus specific real-time PCR, respectively. Results. According to the clinical characteristics, patients were recruited into three groups: RAOM (. Bacterial biofilms were detected in 21 cases, while at least one of the studied respiratory viruses was detected in 52 specimens. RAOM cases were significantly associated with biofilm existence (. In contrast, OME group was characterized by the absence of bacterial biofilm and by normal mucosa. Showing a statistically significant correlation, all OME cases were positive for human bocavirus (HBoV, . Conclusions. Bacterial biofilms might contribute to the damage of respiratory epithelium and recurring acute infections resulting in RAOM. In OME cases persisting respiratory viruses, mainly HBoV, can cause subsequent lymphoid hyperplasia leading to ventilation disorders and impaired immunoreactivity of the middle ear cleft.

  11. International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck

    DEFF Research Database (Denmark)

    Amit, Moran; Binenbaum, Yoav; Trejo-Leider, Leonor;

    2015-01-01

    BACKGROUND: The purpose of this study was to characterize the incidence, pattern of spread, and prognostic correlation of nerve invasion in patients with adenoid cystic carcinoma (ACC). METHODS: Using 3 different pathological categories of perineural invasion, intraneural invasion, and perineural...

  12. THE PRESENCE OF ADENOID VEGETATIONS AND NASAL SPEECH, AND HEARING LOSS IN RELATION TO SECRETORY OTITIS MEDIA

    Directory of Open Access Journals (Sweden)

    Gabriela KOPACHEVA

    2004-12-01

    Full Text Available This study presents the treatment of 68 children with secretory otitis media. Children underwent adenoid vegetations, nasal speech, conductive hearing loss, ventilation disturbance in Eustachian tube. In all children adenoidectomy was indicated.38 boys and 30 girls at the age of 3-17 were divided in two main groups: * 29 children without hypertrophic (enlarged adenoids, * 39 children with enlarged (hypertrophic adenoids.The surgical treatment included insertion of ventilation tubes and adenoidectomy where there where hypertrophic adenoids.Clinical material was analyzed according to hearing threshold, hearing level, middle ear condition estimated by pure tone audiometry and tympanometry before and after treatment. Data concerning both groups were compared.The results indicated that adenoidectomy combined with the ventilation tubes facilitates secretory otitis media heeling as well as decrease of hearing impairments. That enables prompt restoration of the hearing function as an important precondition for development of the language, social, emotional and academic development of children.

  13. 儿童腺样体肥大切除术的临床疗效%Clinical Effect of Adenoid Resection in Children with Adenoid Hypertrophy

    Institute of Scientific and Technical Information of China (English)

    黄芳辉; 曾友根

    2016-01-01

    Objective:To investigate the adenoid hypertrophy in children’s relationship with related complications,strive for early diagnosis,early treatment and reduce the occurrence of complications. Method: 36 children with adenoid hypertrophy in our hospital were selected from February 2014 to February 2016, the age, gender, complications, treatment and curative effect were analyzed.Result:36 patients with adenoid hypertrophy,31 cases with merge and sleep apnea,22 cases with secretory otitis media,8 cases with sinusitis. Postoperative follow-up of 1 month, snoring, improve hearing, stuffy nose, nasal drip efficient was 96.8%, 86.4%, 87.5% and 75.0% respectively.Conclusion:Adenoid hypertrophy in children with sleep apnea,secretory otitis media and sinusitis.Definite diagnosis as soon as possible,take timely adenoidectomy,reduce complications,can obtain satisfactory curative effect, avoid affect children’s growth and development.%目的:探讨儿童腺样体肥大与相关并发症的关系,争取早诊断,早治疗,减少并发症的发生。方法:选择2014年2月-2016年2月在本院住院儿童腺样体肥大患者36例,对其年龄、性别、并发症、诊治和疗效进行分析。结果:36例腺样体肥大患者,合并鼾症31例,合并分泌性中耳炎22例,合并鼻窦炎8例。及时采取腺样体切除术后随访1个月,打鼾、听力改善、鼻塞、鼻漏有效率分别为96.8%、86.4%、87.5%、75.0%。结论:儿童腺样体肥大可并发鼾症、分泌性中耳炎、鼻窦炎。尽早明确诊断,及时采取腺样体切除术,减少并发症产生,可获得满意疗效,避免影响儿童生长发育。

  14. Sinonasal adenoid cystic carcinoma following formaldehyde exposure in the operating theatre.

    Science.gov (United States)

    Sandvik, Anniken; Klingen, Tor Audun; Langård, Sverre

    2014-01-01

    We present a case report of an auxiliary nurse who developed an adenoid cystic carcinoma in her left maxillary sinus following occupational exposure to formaldehyde in the operating theatre. Currently, the epidemiological evidence that formaldehyde can cause cancer in humans is considered to be limited. Previous case-control-studies of formaldehyde and sinonasal cancer have mainly investigated subjects who were concomitantly exposed to wood dust, a known risk factor to the development of sinonasal adenocarcinoma of intestinal type. Our case report presents a patient who has developed an adenoid cystic carcinoma following exposure to formaldehyde. We suggest that the occupational physician remains alert to formaldehyde as an occupational hazard among health care workers.

  15. Cervical Lymph Node Metastasis: Unusual Presentation of Adenoid Cystic Carcinoma - Diagnosed By FNAC

    Directory of Open Access Journals (Sweden)

    Archana Buch

    2015-01-01

    Full Text Available Adenoid cystic carcinoma (ACC is a rare neoplasm that usually arises from minor salivary glands. It is characteristically locally infiltrative, exhibiting perineural invasion, has a tendency for local recurrence and prolonged clinical course. A 60 year old male, chronic smoker presented with swelling of the left cervical lymph node since two months. Examination revealed a solitary firm, non tender, non mobile left cervical swelling measuring 2 x 1 cm. Fine Needle Aspiration Cytology (FNAC was done from the cervical lymph node. The diagnosis of metastatic deposits of ACC was given. Detail examination of the oral cavity revealed a small swelling at the floor of the mouth. Biopsy of the swelling confirmed ACC on histopathological examination. An unusual feature of adenoid cystic carcinoma is the low incidence of metastases to regional lymph nodes. The case is presented to highlight its unusual presentation and utility of FNAC in rapid diagnosis.

  16. ALLERGIC RHINITIS AND ADENOID HYPERTROPHY IN CHILDREN: IS ADENOIDECTOMY ALWAYS REALLY USEFUL?

    Science.gov (United States)

    Colavita, L; Miraglia Del Giudice, M; Stroscio, G; Visalli, C; Alterio, T; Pidone, C; Pizzino, M R; Arrigo, T; Chimenz, R; Salpietro, C; Cuppari, C

    2015-01-01

    Allergic rhinitis (AR) and adenoid hypertrophy (AH) are common in children and are often associated with each other. Recent studies have shown improvement of respiratory symptoms and reduction in the adenoid volume after anti-allergic medical therapy (intranasal corticosteroids, antihistamines). The aim of our retrospective study is to evaluate the effectiveness of adenoidectomy on respiratory symptoms in pediatric patients with AR. We recruited 404 pediatric patients with AR, and we divided them into 4 groups (1. intermittent-mild rhinitis; 2. intermittent-moderate/severe rhinitis; 3. persistent-mild rhinitis; 4. persistent-moderate/severe rhinitis), using ARIA classification. For each patient we evaluated: age at onset of AR; family history of allergy; the presence of other allergic diseases; serum total IgE values; skin prick test (SPT) results; presence of AH evaluated by rhino-laringeal fibroscopy; adenoidectomy and its efficacy on respiratory symptoms. Our data show an association between AR and AH: 90 of 404 (22%) children with AR had AH of a degree greater than 2nd. A significant percentage (80%) of children suffering from AR did not present satisfactory benefits from adenoidectomy. They reported persistence or recurrence of rhinitic symptoms after surgery or only partial benefits, especially of recurrent respiratory tract infections and nasal obstruction. The local allergic persistent inflammation on nasal mucosa and adenoid tissue is probably the cause of the unsatisfactory results of adenoidectomy, therefore surgery cannot be the first therapeutic step for these children. It is important to extinguish the local inflammation by medical anti-allergic therapy to obtain improvements of nasal symptoms and to prevent adenoid regrowth.

  17. Hypertrophic adenoid is a major infection site of human bocavirus 1.

    Science.gov (United States)

    Proenca-Modena, J L; Paula, F E; Buzatto, G P; Carenzi, L R; Saturno, T H; Prates, M C; Silva, M L; Delcaro, L S; Valera, F C P; Tamashiro, E; Anselmo-Lima, W T; Arruda, E

    2014-08-01

    Human bocavirus 1 (HBoV1) is associated with respiratory infections worldwide, mainly in children. Similar to other parvoviruses, it is believed that HBoV1 can persist for long periods of time in humans, probably through maintaining concatemers of the virus single-stranded DNA genome in the nuclei of infected cells. Recently, HBoV-1 was detected in high rates in adenoid and palatine tonsils samples from patients with chronic adenotonsillar diseases, but nothing is known about the virus replication levels in those tissues. A 3-year prospective hospital-based study was conducted to detect and quantify HBoV1 DNA and mRNAs in samples of the adenoids (AD), palatine tonsils (PT), nasopharyngeal secretions (NPS), and peripheral blood (PB) from patients undergoing tonsillectomy for tonsillar hypertrophy or recurrent tonsillitis. HBoV1 was detected in 25.3% of the AD samples, while the rates of detection in the PT, NPS, and PB samples were 7.2%, 10.5%, and 1.7%, respectively. The viral loads were higher in AD samples, and 27.3% of the patients with HBoV had mRNA detectable in this tissue. High viral loads and detectable mRNA in the AD were associated with HBoV1 detection in the other sample sites. The adenoids are an important site of HBoV1 replication and persistence in children with tonsillar hypertrophy. The adenoids contain high HBoV1 loads and are frequently positive for HBoV mRNA, and this is associated with the detection of HBoV1 in secretions.

  18. EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR IN DIFFERENT SALIVARY ADENOID CYSTIC CARCINOMA CELL LINES

    Institute of Scientific and Technical Information of China (English)

    MA Jie; ZONG Zhi-hong; WANG Zhao-yuan

    2005-01-01

    Objective: To investigate the expression of epidermal growth factor receptor, a receptor tyrosine protein kinase, in the subcellular fractions of human salivary adenoid cystic carcinoma cell lines SACC-83 and SACC-LM. Methods: Low metastatic and high metastatic cells of the adenoid cystic carcinoma, SACC-83 and SACC-LM, were cultured. Their subcellular fractions were extracted. The expression of epidermal growth factor receptor was detected with Western blot method, and the results of protein expression were quantitatively analyzed by FluorChem V2.0 software. Results: The results of Western blot analysis indicated that, EGFR expression on the membrane of SACC-83 cells was significantly higher than that of SACC-LM cells, but its expression in cytoplasm was significantly less in the former than the later (P<0.01). In SACC-83 cell line, EGFR was over-expressed in membrane (P<0.01), but in SACC-LM cell line, EGFR was over-expressed in cytoplasm (P<0.01). Conclusion: The results suggest that the obtaining of metastasis ability is related to the high expression of EGFR protein in cytoplasm, so the molecular targeting therapy to EGFR may be an ideal treatment for the invasion and metastasis of salivary adenoid cystic carcinoma.

  19. La dermatomyosite paranéoplasique révélant un carcinome indifférencié du nasopharynx: à propos d'un cas

    Science.gov (United States)

    Ziani, Fatima Zahra; Brahmi, Sami Aziz; Najib, Rajae; Kanab, Rajae; Arifi, Samia; Mernissi, Fatima Zahra; Mellas, Nawfal

    2016-01-01

    La dermatomyosite (DM) est une maladie inflammatoire d'origine inconnue qui se manifeste sous forme de myopathie associée à lésions cutanées typiques. L'association DM et cancer est fréquente (18 a 32% selon les séries). Décrite pour la première fois par Stertz en 1916 en association avec un cancer gastrique. Tous les types histologiques et toutes les localisations de cancers observés danss la population générale peuvent être associés à la DM. Son association avec le carcinome nasopharyngé (NPC) est peu décrite et de l'ordre d'un cas pour 1000 cas de cancer nasopharyngé. Nous rapportons une observation de dermatomyosite révélant un cancer du nasopharynx localement avance. PMID:27583093

  20. La place de l'imagerie par résonance magnétique dans le carcinome lobulaire du sein

    OpenAIRE

    Bouzoubaa, Wail; Laadioui, Meryem; Alaoui, Fatime Zahra Fdili; Jayi, Sofia; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2014-01-01

    Le carcinome lobulaire reste une entité histologique peu fréquente du cancer du sein, toute fois la place qu'occupe le cancer du sein actuellement dans la cancérologie féminine, justifie la connaissance des particularités de ce type de cancer mammaire. Le diagnostic paraclinique est basée sur le couple écho-mammographie a la recherche de multifocalité, multicentricité ou bilatéralité, d'où l'intérêt de l'IRM qui est la technique la plus sensible pour la mise en évidence de ces lésions et qui ...

  1. Lower Female Genital Tract Tumors With Adenoid Cystic Differentiation: P16 Expression and High-risk HPV Detection.

    Science.gov (United States)

    Xing, Deyin; Schoolmeester, J Kenneth; Ren, Zhiyong; Isacson, Christina; Ronnett, Brigitte M

    2016-04-01

    Lower female genital tract tumors with adenoid cystic differentiation are rare, and data on their relationship with high-risk human papillomavirus (HPV) are limited. Here we report the clinicopathologic features from a case series. Tumors with adenoid cystic differentiation, either pure or as part of a carcinoma with mixed differentiation, arising in the lower female genital tract were evaluated by means of immunohistochemical analysis for p16 expression and in situ hybridization using 1 or more probes for high-risk HPV (a high-risk probe covering multiple types, a wide-spectrum probe, and separate type-specific probes for HPV16 and HPV18) and when possible by polymerase chain reaction for high-risk HPV. Six cervical carcinomas with adenoid cystic differentiation admixed with various combinations of at least 1 other pattern of differentiation, including adenoid basal tumor (epithelioma and/or carcinoma), squamous cell carcinoma (basaloid or keratinizing), and small cell carcinoma were identified in patients ranging in age from 50 to 86 years (mean, 73 y; median, 76 y). All of these tumors were characterized by diffuse p16 expression. High-risk HPV was detected in 5 of 6 tested cases: 4 cases by in situ hybridization (all positive for HPV-wide-spectrum and HPV16) and 1 by polymerase chain reaction (HPV45). Seven pure adenoid cystic carcinomas (6 vulvar and 1 cervical) were identified in patients ranging in age from 27 to 74 years (mean, 48 y; median, 48 y). All of these tumors were characterized by variable p16 expression ranging from very limited to more extensive but never diffuse. No high-risk HPV was detected in any of these pure tumors. Lower female genital tract carcinomas with adenoid cystic differentiation appear to comprise 2 pathogenetically distinct groups. Cervical carcinomas with mixed differentiation, including adenoid cystic, adenoid basal, squamous, and small cell components, are etiologically related to high-risk HPV and can be identified by diffuse

  2. [The case of carcinoma adenoides cysticum of the tongue, the trachea and the thyroid gland].

    Science.gov (United States)

    Wojdas, Andrzej; Jurkiewicz, Dariusz; Kenig, Dagmara; Rapiejko, Piotr

    2004-01-01

    We present a case of a 65-year-old female patient who was for the first time admitted to the clinic in 1997 due to a tuber of the tongue root. The removed tuber turned out to be histopatologically a polymorphic adenoma. The patient was re-admitted to the Clinic in 2001 due to a tuber of the tongue and of the oral cavity bottom. The tuber was removed entirely through a central incision, and an apart hypertrophic change has been found on the posterior pharynx wall and in the scar after the tracheostomy carried out during the previous surgery. In all cases carcinoma adenoides cysticum has been found, as well as metastasis into the thyroid gland and the lungs. The patient was qualified for chemotherapy in the Institute of Oncology, which she has been going through periodically every two weeks until now. In 2002 the patient was operated on a small tuber located hypodermically in the scar after the tracheotomy, which was removed. Carcinoma adenoides cysticum was found. In November 2002, during the surgery a tumorous infiltration of the thyroid gland was found comprehending trachea and reaching the mediastenum. In February 2003 the patient was re-admitted to the Clinic due to dyspnoea caused by a significant contraction of the trachea which occurred as a result of a focus of carcinoma adenoides cysticum and significantly enlarged lymph glands near the trachea. The patient was qualified for stent placement in the Institute of Pulmonary Disease and Tuberculosis (Instytut Chorób Płuc i Gruźlicy). The presented case describes an exceptionally aggressive and polyfocal regrowth and transformation of a polymorphic adenoma into cancer.

  3. Familial multiple eccrine spiradenomas with cylindromatous features associated with epithelioma adenoides cysticum of Brooke.

    Science.gov (United States)

    Berberian, B J; Sulica, V I; Kao, G F

    1990-07-01

    Four cases of rare familial multiple eccrine spiradenomas showing features of dermal cylindromas and associated with epithelioma adenoides cysticum of Brooke are reported. Skin biopsy specimens were obtained from three generations of this family and routine histochemical and immunoperoxidase stains were used. The eldest affected family member had multiple disfiguring facial and scalp tumors, which precipitated episodes of depression. Unlike other cutaneous genetic disorders, such as neurofibromatosis and tuberous sclerosis, the cutaneous adnexal tumors occurring in these patients continue to erupt and grow during their lifetimes.

  4. Adenoid cystic carcinoma of the Bartholin's gland:a case report and review of the literature

    Institute of Scientific and Technical Information of China (English)

    Jing Dongzhen; Yin Juan; Liu Yang; Shao Yi; Yang Xingsheng; Zhang Tingguo

    2012-01-01

    Adenoid cystic carcinoma (ACC) of the Bartholin's gland is a rare malignant tumor of vulvar which is characterized by slow growth,local invasion and perineural infiltration.The survival rates for 10 years range from 50% to 100%.The disease free interval for 10 years range from 33% to 38%.Currently,there is no consensus on the treatment of ACC of the Bartholin's gland.Primary surgery includes wide local excision or radical vulvectomy with or without lymph node dissection.Adjuvant radiotherapy and chemotherapy are advocated for the treatment of this cancer.Work is still needed to identify an effective systemic therapy.

  5. Ectopic thyroid papillary carcinoma of nasopharynx associated with adenoid hypertrophy: an unusual presentation.

    Science.gov (United States)

    Tian, Linli; Jiao, Yufei; Liu, Ming; Li, Minghua; Yao, Hongchao

    2014-09-20

    Ectopic thyroid tissue of nasopharynx is an uncommon phenomenon and papillary thyroid carcinoma arising from the tissue is extremely rare. The authors report a rare case of 16-year-old girl with papillary thyroid carcinoma of nasopharynx. Clinicians were ever confused by adenoid hypertrophy and solved the diagnostic dilemma by adequate examinations. In the case, we mainly emphasize that surgeons should be aware of and actively consider such a possibility of ectopic papillary thyroid carcinoma of nasopharynx in children and adolescents with long-term nasal obstruction, even if thyroid carcinoma is a rare tumor.

  6. Life-Threatening Obstructive Sleep Apnea Caused by Adenoid Hypertrophy in an Infant with Noonan Syndrome

    Directory of Open Access Journals (Sweden)

    Sonia Khirani

    2012-01-01

    Full Text Available Adenoidectomy is a commonly performed surgery in children, even though its effectiveness is still under investigation. However, in children with risk factors such as age under 3 years old, associated comorbidities, or severe obstructive sleep apneas, a high postoperative respiratory morbidity is possible. We report the case of a 15-month-old boy with Noonan syndrome and a complex clinical history, who presented with a life-threatening obstructive sleep apnea due to hypertrophy of the adenoids which resolved completely after adenoidectomy.

  7. Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma

    DEFF Research Database (Denmark)

    Amit, Moran; Binenbaum, Yoav; Sharma, Kanika;

    2015-01-01

    BACKGROUND: The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. METHODS: We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. RESULTS: The incidence...

  8. Utility of antimicrobial susceptibility testing of multiple Haemophilus influenzae isolates from throat swabs of children with adenoid hypertrophy.

    Science.gov (United States)

    Antos-Bielska, Małgorzata; Lau-Dworak, Magdalena; Olszewska-Sosińska, Olga; Zielnik-Jurkiewicz, Beata; Trafny, Elżbieta A

    2014-07-01

    Eleven out of 40 children with adenoiditis were colonized with multiple genotypes of Haemophilus influenzae. Heterogeneous antibiotic susceptibility to ampicillin and cotrimoxazole was observed in 6 children. A multiple-colony methodology may potentially help to find the resistant strains of H. influenzae in patients who do not respond to the antibiotic treatment.

  9. Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study

    DEFF Research Database (Denmark)

    Amit, Moran; Binenbaum, Yoav; Sharma, Kanika

    2014-01-01

    BACKGROUND Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The current study aimed to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review of 489 ACC patients...

  10. Epithelial Cell Culture from Human Adenoids: A Functional Study Model for Ciliated and Secretory Cells

    Directory of Open Access Journals (Sweden)

    Claudia González

    2013-01-01

    Full Text Available Background. Mucociliary transport (MCT is a defense mechanism of the airway. To study the underlying mechanisms of MCT, we have both developed an experimental model of cultures, from human adenoid tissue of ciliated and secretory cells, and characterized the response to local chemical signals that control ciliary activity and the secretion of respiratory mucins in vitro. Materials and Methods. In ciliated cell cultures, ciliary beat frequency (CBF and intracellular Ca2+ levels were measured in response to ATP, UTP, and adenosine. In secretory cultures, mucin synthesis and secretion were identified by using immunodetection. Mucin content was taken from conditioned medium and analyzed in the presence or absence of UTP. Results. Enriched ciliated cell monolayers and secretory cells were obtained. Ciliated cells showed a basal CBF of 10.7 Hz that increased significantly after exposure to ATP, UTP, or adenosine. Mature secretory cells showed active secretion of granules containing different glycoproteins, including MUC5AC. Conclusion. Culture of ciliated and secretory cells grown from adenoid epithelium is a reproducible and feasible experimental model, in which it is possible to observe ciliary and secretory activities, with a potential use as a model to understand mucociliary transport control mechanisms.

  11. Expression of Innate Immunity Genes in Epithelial Cells of Hypertrophic Adenoids with and without Pediatric Chronic Rhinosinusitis: A Preliminary Report

    Institute of Scientific and Technical Information of China (English)

    Xiao-Peng Qu; Zhen-Xiao Huang; Yan Sun; Ting Ye; Shun-Jiu Cui; Qian Huang; Li-Jing Ma

    2015-01-01

    Background:Adenoid hypertrophy (AH) is associated with pediatric chronic rhinosinusitis (pCRS),but its role in the inflammatory process of pCRS is unclear.It is thought that innate immunity gene expression is disrupted in the epithelium of patients with chronic rhinosinusitis (CRS),including antimicrobial peptides and pattern recognition receptors (PRRs).The aim of this preliminary study was to detect the expression of innate immunity genes in epithelial cells of hypertrophic adenoids with and without pCRS to better understand their role in pCRS.Methods:Nine pCRS patients and nine simple AH patients undergoing adenoidectomy were recruited for the study.Adenoidal epithelium was isolated,and real-time quantitative polymerase chain reaction (RT-qPCR) was employed to measure relative expression levels of the following messenger RNAs in hypertrophic adenoid epithelial cells of pediatric patients with and without CRS:Human β-defensin (HBD) 2 and 3,surfactant protein (SP)-A and D,toll-like receptors 1-10,nucleotide-binding oligomerization domain (NOD)-like receptors NOD 1,NOD 2,and NACHT,LRR and PYD domains-containing protein 3,retinoic acid-induced gene 1,melanoma differentiation-associated gene 5,and nuclear factor-KB (NF-κB).RT-qPCR data from two groups were analyzed by independent sample t-tests and Mann-Whitney U-tests.Results:The relative expression of SP-D in adenoidal epithelium of pCRS group was significantly lower than that in AH group (pCRS 0.73 ± 0.10 vs.AH 1.21 ± 0.15;P =0.0173,t =2.654).The relative expression levels of all tested PRRs and NF-κB,as well as HBD-2,HBD-3,and SP-A,showed no statistically significant differences in isolated adenoidal epithelium between pCRS group and AH group.Conclusions:Down-regulated SP-D levels in adenoidal epithelium may contribute to the development of pCRS.PRRs,however,are unlikely to play a significant role in the inflammatory process of pCRS.

  12. Expression of Innate Immunity Genes in Epithelial Cells of Hypertrophic Adenoids with and without Pediatric Chronic Rhinosinusitis: A Preliminary Report

    Directory of Open Access Journals (Sweden)

    Xiao-Peng Qu

    2015-01-01

    Full Text Available Background: Adenoid hypertrophy (AH is associated with pediatric chronic rhinosinusitis (pCRS, but its role in the inflammatory process of pCRS is unclear. It is thought that innate immunity gene expression is disrupted in the epithelium of patients with chronic rhinosinusitis (CRS, including antimicrobial peptides and pattern recognition receptors (PRRs. The aim of this preliminary study was to detect the expression of innate immunity genes in epithelial cells of hypertrophic adenoids with and without pCRS to better understand their role in pCRS. Methods: Nine pCRS patients and nine simple AH patients undergoing adenoidectomy were recruited for the study. Adenoidal epithelium was isolated, and real-time quantitative polymerase chain reaction (RT-qPCR was employed to measure relative expression levels of the following messenger RNAs in hypertrophic adenoid epithelial cells of pediatric patients with and without CRS: Human β-defensin (HBD 2 and 3, surfactant protein (SP-A and D, toll-like receptors 1-10, nucleotide-binding oligomerization domain (NOD-like receptors NOD 1, NOD 2, and NACHT, LRR and PYD domains-containing protein 3, retinoic acid-induced gene 1, melanoma differentiation-associated gene 5, and nuclear factor-κB (NF-κB. RT-qPCR data from two groups were analyzed by independent sample t-tests and Mann-Whitney U-tests. Results: The relative expression of SP-D in adenoidal epithelium of pCRS group was significantly lower than that in AH group (pCRS 0.73 ± 0.10 vs. AH 1.21 ± 0.15; P = 0.0173, t = 2.654. The relative expression levels of all tested PRRs and NF-κB, as well as HBD-2, HBD-3, and SP-A, showed no statistically significant differences in isolated adenoidal epithelium between pCRS group and AH group. Conclusions: Down-regulated SP-D levels in adenoidal epithelium may contribute to the development of pCRS. PRRs, however, are unlikely to play a significant role in the inflammatory process of pCRS.

  13. Prognostic significance of p53 immunohistochemical expression in adenoid cystic carcinoma of the salivary glands: a meta-analysis.

    Science.gov (United States)

    Li, Qinglin; Huang, Ping; Zheng, Chuanming; Wang, Jiafeng; Ge, Minghua

    2017-02-11

    Adenoid cystic carcinoma of salivary glands is a rare adenocarcinoma and has been placed in "high-risk" category as poor long-term prognosis. The purpose of this study was to investigate p53 protein expression in adenoid cystic carcinoma of salivary glands and its correlation with clinicopathological parameters and prognosis. Literatures were searched from PubMed, Embase, Cochrane Library and Web of Science, which investigated the relationships between p53 expression and pathological type, clinical stage, local recurrence, metastasis, nerve infiltration and overall survival. A total of 1,608 patients from 36 studies were included in the analysis. The results showed that p53-postive expression rate was 49% in adenoid cystic carcinoma of salivary glands (OR=10.34, 95%CI: 4.93-21.71, P p53-postive expression was closely related to tumor types (OR=0.30, 95%CI: 0.14-0.65, P p53 expression. The combined analysis revealed that the p53-positive expression rate among patients in T1and T2 stage was 41.4%, compared to 53.2% among those in T3 and T4 stage. However, there was no significant correlation between tumor stage and p53 expression (OR=0.47, 95% CI: 0.17-1.29, P = 0.14). Besides, compared to patients with p53-negative expression, those with p53-positive expression had a greater chance of developing metastasis, local recurrence and nerve infiltration as well as poorer 5-year overall survival (P p53 expression is related to the survival of adenoid cystic carcinoma of salivary glands. It can be considered as the auxiliary detection index in treatment and prognosis of adenoid cystic carcinoma of salivary glands.

  14. Le carcinome neuro-endocrine cutané primitif: à propos d'un nouveau cas et revue de la littérature

    Science.gov (United States)

    Boukind, Samira; Elatiqi, Oumkeltoum; Dlimi, Meriem; Elamrani, Driss; Benchamkha, Yassine; Ettalbi, Saloua

    2015-01-01

    Le carcinome neuro- endocrine cutané primitif (CNEC) est une tumeur cutanée rare et agressive du sujet âgé, favorisée par le soleil et l'immunodépression. Elle est caractérisée par une évolution agressive avec un fort taux de récidive, une évolution ganglionnaire régionale et un risque de métastases à distance. Nous rapportons un cas de cette tumeur chez un patient âgé de 67 ans sous forme d'un placard nodulaire hémorragique mesurant 16 /14 cm. Le patient a bénéficié d'une exérèse chirurgicale large avec couverture de la perte de substance par un lambeau musculo-cutané du muscle grand dorsal, un curage ganglionnaire axillaire et une radiothérapie adjuvante. Après un recul de 2 ans et 2 mois, le patient est toujours vivant sans métastase ni récidive. La littérature étant pauvre, la prise en charge diagnostique et thérapeutique est controversée et donc hétérogène. Globalement le pronostic est mauvais, et certains paramètres corrélés au pronostic sont précisés. PMID:26185585

  15. Relationship between adenoidal morphology and secretory otitis media in children with adenoidal hypertrophy%腺样体肥大患儿腺体形态与分泌性中耳炎的关系

    Institute of Scientific and Technical Information of China (English)

    刘振华; 谷京城; 刘盛林; 穆兰; 杨蒙生; 暴继敏; 孟大为; 陈鲁赞; 曲成晶

    2011-01-01

    目的 探讨腺样体肥大患儿腺体形态与分泌性中耳炎(SOM)的关系.方法 腺样体肥大合并SOM的患儿33例(病例组),单纯腺样体肥大无耳部症状的患儿47例(对照组).两组患儿术前行鼻咽侧位数字化摄影(DR)检查;观察腺样体形态后将其完整切除,测量腺样体密度.结果 病例组各年龄段鼻咽后气道宽度(P值)、腺样体厚度/鼻咽腔宽度( A/N)小于对照组(P均<0.01).病例组颗粒滤泡型、橘瓣型、平坦型腺样体分别为21、7、5例,对照组分别为7、21、19例,两组相比,P<0.01.病例组腺样体密度为(1.5422±0.1392)g/cm3,对照组为(1.1315 ±0.058 2) g/cm3,两组相比,P<0.01.结论 腺样体肥大患儿腺体形态与SOM的关系密切,P值和A/N不但可反映腺样体肥大程度,亦能显示气道阻塞程度,并可作为SOM的诊断依据.%Objective To study the relationship between adenoidal morphology and secretory otitis media(SOM). Methods 33 children with adenoidal hypertrophy and SOM ( case group) , 47 children with onlg adenoidal hypertrophy ( control group). The nasopharyngeal lateral digital photography ( DR) was taked preoperative in two groups. The adneoids were observed and resected, and it's density was tested. Results The nasopharyngeal airway width (P value) , adenoid thickness/nasopharyngeal airway width (A/N) in case group was less than that in the control group (all P<0.01). The particles follicular, orange flap-type, flat type adenoids were 21,7,5 cases in case group, 7 ,21 ,19 cases in control group , the two groups were compared, P<0.01. The adenoid density was (1. 542 2 ±0. 139 2) g/cmJ in case group, (1.1315 ±0.058 2) g/cm3 in control group, the two groups were compared, P<0.01. Conclusions There is a close relationship between adenoidal morphology and SOM in children with adenoidal hypertrophy. P value and A/N not only reflect the de gree of adenoid hypertrophy, can also show the degree of airway obstruction, can serve as a

  16. Relationship Between Adenoidal Hypertrophy and Secretory Otitis Media in Children%儿童腺样体肥大与分泌性中耳炎的关系

    Institute of Scientific and Technical Information of China (English)

    敬云龙; 赵斯君; 陶礼华; 李?; 贺定华

    2012-01-01

    [目的]探讨腺样体的形态和大小与分泌性中耳炎(SOM) 的相关性.[方法]手术中根据腺样体与咽鼓管圆枕间接触的紧密程度,将腺样体的形态依次分为四组,分析各种分型在伴SOM和不伴SOM的患儿中的差异;并根据腺样体肥大的程度,将138例患儿分为腺样体中度肥大组和病理性肥大组,分析腺样体肥大程度对中耳功能的影响及两组间SOM 发病率的差异.[结果]在有无SOM方面,无压迫型的腺样体形态具有极显著性差异,而挤压型、紧贴型、混合型的腺样体形态组间的差异均不显著(P>0.05);病理性肥大组中SOM的发病率明显高于中度肥大组,组间具有显著性差异(P<0.05).[结论]腺样体的形态和肥大程度与SOM 发病率有密切关系.%[Objective] To explore the relationship between the shape of adenoids and secretory otitismedia(SOM). [Methods] According to the compactness of adenoids in touch with torus tubarius during the operation, adenoids were categorized into 4 groups. The difference of various types of adenoids between chil dren with and without SOM was analyzed. According to the grades of adenoid hypertrophy, 138 children were divided into moderate adenoid hypertrophy group and pathological adenoid hypertrophy group. The effect of the grades of adenoid hypertrophy on middle ear function and the difference of the incidence of SOM were ana lyzed. [Results] There was significant difference in the shape of adenoids without oppression group between the children with and without SOM, but there was no significant difference in the shape of adenoids with op pression, tightness or mixture between the children with and without SOM( P X). 05). The incidence of SOM in pathological adenoid hypertrophy group was obviously higher than that in moderate hypertrophy group, and there was significant difference among groups ( P <0. 05). [Conclusion] The shape and hypertrophy of ade noid are closely related with the incidence of SOM.

  17. Assessment of middle ear effusion and audiological characteristics in young children with adenoid hypertrophy

    Institute of Scientific and Technical Information of China (English)

    REN Dong-dong; WANG Wu-qing

    2012-01-01

    Background Otitis media with effusion is a highly concurrent disease in young children with adenoid hypertrophy.The aim of this study was to assess the middle ear effusion and audiological characteristics in children with adenoid hypertrophy and compare the various assessment methods.@@Methods Two hundred and seven candidates who were to undergo adenoidectomy were analyzed using otoscopy,tympanometry,air-conduction auditory steady-state responses (AC-ASSR),and computerized tomography (CT) before adenoidectomy.@@Results About 73.4% (304/414) of ears were confirmed to have middle ear effusion (MEE) by otoscopy; 75.4% (312/414) of ears revealed MEE by CT.CT scan correctly predicted all the myringotomy results,giving 100% accuracy on the diagnosis of MEE.Additionally,CT revealed two children with inner ear malformations.Type B tracing tympanogram provided a sensitivity of 91.7% and a specificity of 92.2%.Type C tympanogram with peak pressure <-200 daPa indicated effusion; type C tympanogram having acoustic stapedius reflex could exclude MEE.We excluded the AC-ASSR results of the 4 ears with malformation; 54.4% (223/410) of ears were confirmed of hearing loss.Furthermore,5.2%(16/310) of the ears with MEE suffered from severe to profound hearing loss.The average threshold level in the 0.25 kHz frequency of children was found to have poorer hearing thresholds than those in the 0.5,1,2,and 4 kHz (P <0.001) frequencies; 29.7% (92/310) of ears with MEE were regarded as normal hearing level.About 55.8% (173/310) of ears with MEE were classified as having slight-mild hearing loss.@@Conclusions The practitioners should pay much attention to the middle ear condition and be aware of a possible development of severe to profound hearing loss during the course of MEE in young children with adenoid hypertrophy.CT scan is good for the assessment of MEE before ventilation tube insertion.

  18. The role of mometasone furoate nasal spray in the treatment of adenoidal hypertrophy in the adolescents: a prospective, randomized, cross-over study.

    Science.gov (United States)

    Yilmaz, Huseyin Baki; Celebi, Saban; Sahin-Yilmaz, Asli; Oysu, Cagatay

    2013-09-01

    Aim of this work is to find out whether the symptoms attributable to adenoid hypertrophy in adolescents may be treated with intranasal mometasone furoate (MF) application. To learn if adenoid hypertrophy in adolescents may decrease in size with intranasal MF. A prospective, double blind, randomized, cross-over study was conducted in 28 subjects (12-18 years) with adenoidal hypertrophy. Subjects used intranasal MF or placebo for a duration of 6 weeks with a wash out period of 3 weeks. Subjective symptoms and adenoid size were evaluated. At the initiation of the study, there was no significant difference between the mean symptom scores for any of the sinonasal symptoms between the two treatment groups. There was significant improvement in total subjective symptoms (nasal blockage, rhinorrhea, cough, snoring and disruption of quality of life scores) with MF compared with placebo. Analysis of the symptoms separately showed a significant positive effect of MF on all symptoms except for rhinorrhea. Nasal endoscopic evaluation failed to demonstrate any difference in the reduction of the adenoid size between the two groups. MF has significant advantage over placebo for the symptoms attributable to adenoid hypertrophy in adolescents.

  19. Transformation of epithelioma adenoides cysticum into multiple rodent ulcers: fact or fallacy. A historical vignette.

    Science.gov (United States)

    Howell, J B; Anderson, D E

    1976-09-01

    This historical study has examined the persistent controversy about the propensity of epithelioma adenoides cysticum (EAC) to transform into multiple rodent ulcers, by reviewing cases reported through the years that seemed to support the idea. After focusing on the biological behaviour and natural history of the tumours and comparing them with our present knowledge of the behaviour of EAC, we believe that these cases were incorrectly diagnosed. Rather than EAC, they were probably examples of the naevoid basal cell carcinoma syndrome. The latter syndrome was actually established by the recognition that patients who have multiple rodent ulcers that appear early in life and behave aggressively usually have a constellation of associated developmental defects and that the tumours sould be classified as genetically determined basal cell carcinomas and not as EAC.

  20. Adenoid cystic carcinoma of trachea: a case report and review of literature

    Institute of Scientific and Technical Information of China (English)

    LI Wen; HUA Wen; YAN Fu-gui; SHEN Hua-hao; XU Hao

    2012-01-01

    Pdmary tracheal tumors are relatively rare.Here we report one case of primary adenoid cystic carcinoma of the trachea which was ever misdiagnosed as asthma and hysteria.In this case,the pulmonary function test was normal,and firstly no obvious abnormalities were found in laryngoscopy,bronchoscopy and CT scan of chest,Later a sagittal and coronal reconstruction CT scan of trachea showed a mass situated in the subglottic trachea.Lastly a laryngoscopy was again done after a tracheal incision and showed a small mass in the posterior wall of the subglottic trachea,and tumor ablation was performed.In addition,we reviewed the literature of primary tracheal tumors and summarized the epidemiology,presenting features,available therapeutic options of the disease.

  1. Scanning electron microscopy of damage to the cecal mucosa of turkeys infected with Eimeria adenoides.

    Science.gov (United States)

    Bemrick, W J; Hammer, R F

    1979-01-01

    White Wrolstad turkeys were each inoculated with 100,000 Eimeria adenoides oocysts and killed on days 4-14 postinoculation. Tissue samples, obtained from 4 areas of the ceca comparable to areas examined in chickens infected with E. tenella in previous studies, were processed by a modification of the osmium-thiocarbo-hydrazide-osmium technique and examined with a scanning electron microscope. The pathologic situation found in turkeys was slightly different from that in the ceca of chickens infected with E. tenella. The mucosal lesions are most severe at the proximal end of an infected cecum. Surface disruption was far less severe than with cecal coccidiosis in chickens of the same age exposed to an equal number of infective oocysts. Rupture of the epithelial cell often caused the mucosal surface to present a honeycomb appearance. Some specific stages of the life cycle were identified, including schizonts and oocysts.

  2. Radiologic and pathological correlation of adenoid cystic carcinoma of the breast; A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jung Gyu; Kim, Shin Young; Jung, Hae Yoen; Kim, Sung Yong; Lee, Deuk Young; Park, Sang Hyun [Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan (Korea, Republic of); Park, Sang Hyun [Dept. of Radiology, Plus Internal Medicine Clinic, Suncheon (Korea, Republic of)

    2015-06-15

    Adenoid cystic carcinoma (ACC) is a subtype of adenocarcinoma that is usually seen in the salivary glands. It has also been reported in other organs including the breast, skin, tracheobronchial tree, cervix, larynx, and Bartholin gland. ACC in the breast is rare, accounting for less than 0.1% of all breast cancers. Furthermore, the imaging characteristics of ACC of the breast have not been well described in the literature, especially regarding the findings with magnetic resonance imaging (MRI). Here, we report radiologic findings of a rare case of ACC in the breast by mammography, sonography, computed tomography (CT), positron emission tomography/CT, and MRI with pathologic correlation and a review of the literature.

  3. Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features of the Sinonasal Tract

    DEFF Research Database (Denmark)

    Andreasen, S; Bishop, J; Hansen, T V O;

    2016-01-01

    with adenoid cystic carcinoma (ACC), a rare and aggressive carcinoma originating in the minor salivary glands. Termed HPV-related carcinoma with ACC-like features, only 9 cases have been reported. To clarify the occurrence of these tumours we screened a large material for presence of HPV-related ACC...... as HPV types 33, 35 and 56. All six cases had areas of dysplastic mucosal lining and showed remarkable heterogeneous morphologies. MYB, MYBL1, and NFIB genes were intact and, interestingly, staining for MYB protein was largely negative in contrast to what was found in ACC. One patient experienced a local...... recurrence 11 years after initial treatment and the remaining five patients were alive without evidence of disease. CONCLUSION: We report six new cases of HPV-related ACC-like carcinoma and found that, although in a small material, the prognosis for these patients seems more favourable than for ACC...

  4. ANTIMETASTATIC EFFECT OF INTEGRIN IIb/IIIa INHIBITORS ON SALIVARY ADENOID CYSTIC CARCINOMA

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objectives: To investigate the relation between metastatic potential of salivary adenoid cystic carcinoma (SACC) and tumor cell-platelet adhesion, and the antimetastatic effect of integrin IIb/IIIa inhibitor on SACC. Methods: Tumor cell-platelet adhesion of highly metastatic SACC-LM, non-highly metastatic SACC-83 and effect of aspirin, arginine-aspartate (RD), magnesium acetylsalicylate on adhesion were studied in vitro. Antimetastafic effect of aspirin, RD, magnesium acetysalicylate on experimental metastasis of SACC was observed in vivo. Results: The tumor cell-platelet adhesion was stronger in SACC-LM than in SACC-83. Aspirin, RD and magnesium acetylsalicylate could inhibit the adhesion of SACC-LM at the concentration of 1, 5 and 25 mg/ml. RD can inhibit experimental metastasis of SACC. Conclusion: Metastasis of SACC is related to platelet-tumor cell adhesion, RD could inhibit metastasis of SACC.

  5. Nasal Mucociliary Clearance in Adenoid Hypertrophy and Otitis Media with Effusion.

    Science.gov (United States)

    Yazıcı, Hasmet

    2015-12-01

    Mucociliary clearance (MCC), which exists in many systems, is the first defensive mechanism of the human body. Nasal MCC has an important role in transporting the secretions of the nasal cavity and paranasal sinuses along with the trapped inhaled pathogens to the nasopharynx. Physiologic or pathologic situations that effect nasal MCC, such as temperature, humidity, nasal obstruction, allergic rhinitis, chronic infections, etc., lead to impaired MCC and related local or circumjacent system disorders. With this perspective, when a unified airway with a multiple disease principle is considered, investigating the relationship between adenoid hypertrophy (AH), otitis media with effusion (OME) and nasal MCC is logical. In this review, histological and physiologic properties of nasal MCC and its possible role involving pathologic situations such as AH and OME is discussed together with recent literature findings.

  6. Expressions of chemokine receptor CXCR4 and its ligand CXCL12 in salivary adenoid cystic carcinoma

    Institute of Scientific and Technical Information of China (English)

    徐晓刚; 吕春堂; 周中华

    2004-01-01

    Objective: To examine expressions of chemokine receptor CXCR4 and its ligand CXCL12 in primary focus and lymphogenous metastasis of salivary adenoid cystic carcinoma (ACC) with lung metastasis. Methods: Using immunohistochemical hypersensitivity catalyzed signal amplification (CSA), expressions of chemokine receptor CXCR4 and ligand CXCL12 were detected in tissue specimens from 20 cases of primary cancer focus and lymphogenous metastasis of salivary adenoid cystic carcinoma, of which 7 cases were associated with lung metastasis and 3 with lympogenons metastasis. Twenty cases of tongue carcinoma (including 10 cases with lymphogenous metastasis) and 15 cases of mucoepidermoid carcinoma (including 5 cases with lymphogenous metastasis) were used as the malignant control group; and salivary mixed tumor ( n =10), tongue leukoceratosis ( n = 10) and cervical lymph node reactive hyperplasia ( n = 10) were used as the benign control group. Results: Expression of CXCR4 in the tissues and lymph metastases of oral and maxillofacial salivary ACC, mucoepidermoid carcinoma and tongue carcinoma was significantly higher than that of the benign control group ( P < 0.05); expression of CXCR4 in the primary focus of ACC was significantly higher than that of the malignant control group; and expression of CXCR4 in the ACC with lung metastasis was 87.1% (6/7), significantly higher than that without lung metastasis( P <0.01 ). There was evident positive expression of CXCL12 in endotheliocytes of microvessels within cancer and paracancer tissues and significantly high expression of CXCL12 in lymphogenous metastasis( P < 0.05). Conclusion: Chemokine receptor CXCR4 and its ligand CXCL12 may be associated with local invasion and lymphogenous metastasis of oral and maxillofacial cancer, especially with lung metastasis of salivary ACC.

  7. A subset of prostatic basal cell carcinomas harbor the MYB rearrangement of adenoid cystic carcinoma.

    Science.gov (United States)

    Bishop, Justin A; Yonescu, Raluca; Epstein, Jonathan I; Westra, William H

    2015-08-01

    Adenoid cystic carcinoma (ACC) is a basaloid tumor consisting of myoepithelial and ductal cells typically arranged in a cribriform pattern. Adenoid cystic carcinoma is generally regarded as a form of salivary gland carcinoma, but it can arise from sites unassociated with salivary tissue. A rare form of prostate carcinoma exhibits ACC-like features; it is no longer regarded as a true ACC but rather as prostatic basal cell carcinoma (PBCC) and within the spectrum of basaloid prostatic proliferations. True ACCs often harbor MYB translocations resulting in the MYB-NFIB fusion protein. MYB analysis could clarify the true nature of prostatic carcinomas that exhibit ACC features and thus help refine the classification of prostatic basaloid proliferations. Twelve PBCCs were identified from the pathology consultation files of Johns Hopkins Hospital. The histopathologic features were reviewed, and break-apart fluorescence in situ hybridization for MYB was performed. All 12 cases exhibited prominent basaloid histology. Four were purely solid, 7 exhibited a cribriform pattern reminiscent of salivary ACC, and 1 had a mixed pattern. The MYB rearrangement was detected in 2 (29%) of 7 ACC-like carcinomas but in none (0%) of the 5 PBCCs with a prominent solid pattern. True ACCs can arise in the prostate as is evidenced by the presence of the characteristic MYB rearrangement. When dealing with malignant basaloid proliferations in the prostate, recommendations to consolidate ACCs with other tumor types may need to be reassessed, particularly in light of the rapidly advancing field of biologic therapy where the identification of tumor-specific genetic alterations presents novel therapeutic targets.

  8. Reprodutibilidade dos métodos radiográficos para avaliação da adenoide Reliability of radiographic parameters in adenoid evaluation

    Directory of Open Access Journals (Sweden)

    Murilo Fernando Neuppmann Feres

    2012-08-01

    Full Text Available Embora a avaliação radiográfica da hipertrofia de tonsila faríngea tenha sido constantemente debatida, há ainda carência de estudos que testem a confiabilidade da maioria dos parâmetros radiográficos existentes. OBJETIVO: Verificar a reprodutibilidade intra e interexaminadores de vários métodos destinados à avaliação da tonsila faríngea. Forma de estudo: Estudo de série, metodológico e transversal. MATERIAL E MÉTODO: Quarenta crianças de ambos os sexos, de 4 a 14 anos, foram selecionadas mediante apresentação de queixas de obstrução nasal ou respiração oral, com suspeita de diagnóstico de hipertrofia de tonsila faríngea. Radiografias do cavum faríngeo e telerradiografias ortodônticas foram obtidas e, posteriormente, avaliadas por dois examinadores por meio de instrumentos de avaliação quantitativos e categóricos. RESULTADOS: Todos os parâmetros quantitativos de ambas as modalidades radiográficas apresentaram excelente reprodutibilidade intra e interexaminadores. Dentre os parâmetros categóricos de avaliação da radiografia de cavum, observou-se desempenho relativamente melhor de C-Kurien, C-Wang, C-Fujioka e C-Elwany sobre C-Cohen e C-Ysunza. Em relação aos sistemas destinados à classificação da telerradiografia, C-McNamara apresentou maior reprodutibilidade que C-Holmberg. CONCLUSÃO: A maioria dos instrumentos apresentou reprodutibilidade adequada. No entanto, novas investigações ainda devem ser realizadas com o intuito de determinar a capacidade de cada parâmetro em relação sua acurácia e viabilidade.The assessment of adenoids by x-ray imaging has been the topic of heated debate, but few studies have looked into the reliability of most existing radiographic parameters. OBJECTIVE: This study aims to verify the intra-examiner and inter-examiner reproducibility of the adenoid radiographic assessment methods. MATERIALS AND METHODS: This is a cross-sectional case series study. Forty children of both

  9. Effect of Exogenous bFGF on the Proliferation of Human Adenoid Cystic Carcinoma ACC-2 Cells

    Institute of Scientific and Technical Information of China (English)

    Lei DING; Shengrong ZHU; Sanxiang XIE; Xiangbing WU

    2008-01-01

    To observe the effects of basic fibroblast growth factor (bFGF) on human adenoid cystic carcinoma ACC-2 cell line proliferation and ERK, cyclin D1/p21waf/ciplsignaling pathways, human adenoid cystic carcinoma cells (ACC-2) were cultured and the influence of bFGF of different concentrations on cell proliferation was determined by MTT. Protein was detected by im muno-precipitation and ERK activity by using ERK agent kit. P-ERK1/2 and down-stream cyclin D1, p21waf/ciplexpression were detected by Western blotting and the interfering role of mitogen pro- tein-activated kinase (MEK) suppressor U0126 in the afore-mentioned indicators was examined. MTr demonstrated ACC-2 cell proliferation was substantially enhanced by bFGF, immuo-precipitation displayed ERK activity was up-regulated by bFGF, and immuno-imprinting also showed p-ERK1/2, cyclin D1 expression was greatly enhanced and p21waf/ciplexpression was inhibited by bFGE U0126 suppressed the effect of bFGE It is concluded that bFGF can promote the proliferation of human adenoid cystic carcinoma ACC-2 cells, and its pathways are associated with the up-regulated activity and expression of p-ERK1/2, inhibited p21waf/cipl expression and enhanced cyclin DI expression.

  10. A case of transient cortical blindness associated with hypercapnia as a result of extremely enlarged adenoid tissue.

    Science.gov (United States)

    Malbora, Baris; Malbora, Nihan; Avci, Zekai; Olgac, Asburce; Erkan, Alper Nabi

    2015-01-01

    Adenotonsillar hypertrophy is common among children, but it can lead to serious complications if left untreated. Among the well-known complications are obstructive sleep apnea syndrome, growth failure, cor pulmonale, and hypertension. One complication of adenotonsillar hypertrophy that has not been previously reported in the English-language literature is transient cortical blindness. We describe such a case, which occurred in a 6-year-old boy who presented with a sudden loss of vision and subsequent unconsciousness. He had experienced hypercapnia and was resuscitated via endotracheal tube ventilation. Laboratory and radiologic assessments found no pathology except for extremely enlarged adenoid tissue. Once the patient was stabilized, an urgent adenotonsillectomy was performed. The patient recovered well, and his vision and respiratory symptoms resolved. Severe hypertrophy of the adenoid tissue can cause hypercapnia and acidosis secondary to upper airway obstruction. The possibility of adenoid hypertrophy and hypercapnia should be kept in mind in cases of transient cortical blindness. Aggressive treatment, including early intubation and adenoidectomy, may lead to a rapid resolution of symptoms.

  11. Detection of Respiratory Viruses in Nasopharyngeal Swab and Adenoid Tissue from Children Submitted to Adenoidectomy: Pre- and Postoperative Analysis

    Directory of Open Access Journals (Sweden)

    Biill Primo, Osvaldo Vinícius

    2014-01-01

    Full Text Available Introduction The presence of respiratory viruses in lymphoid tissues of the nasopharynx and oropharynx and its impact on recurrent infections and hypertrophy of these tissues are not yet fully understood. Objective To identify and determine the prevalence of major respiratory viruses in nasopharyngeal secretions and adenoid tissue pre- and postoperatively of children undergoing adenoidectomy. Methods A prospective observational study was conducted in 36 patients under 12 years of age with upper airway lymphoid hypertrophy who were undergoing adenoidectomy, in which various respiratory viruses were investigated using real-time polymerase chain reaction in adenoid tissue and nasopharyngeal secretions collected preoperatively and 30 days postoperatively. Results At least 1 viral agent was isolated in any of the samples collected in 58.3% of children and 25.9% of total samples. Respiratory viruses were identified in 33.8% of preoperative nasopharyngeal specimens and in 19.8% of postoperative secretion. Of the 21 patients with positive results for any respiratory virus, 6 (28.6% had more than 1 virus. Considering all 36 respiratory viruses found, the main agent isolated was rhinovirus (27.8%, followed by bocavirus (22.2%. Conclusion The virus found more frequently in all samples was rhinovirus. After removal of adenoid tissue, there was a decrease in the prevalence of the virus contained in nasopharyngeal secretion 30 days after surgery.

  12. Increased percentage of T cells with the expression of CD127 and CD132 in hypertrophic adenoid in children with otitis media with effusion.

    Science.gov (United States)

    Żelazowska-Rutkowska, Beata; Wysocka, Jolanta; Ratomski, Karol; Kasprzycka, Edwina; Skotnicka, Bożena

    2012-07-01

    The hypertrophic adenoid may promote chronic suppurative otitis media in children as it fulfills its immune function. The number of lymphocytes in the adenoid and their cooperation in the immune response depend of on their proliferation and migration to the effector sites. Interleukin 7 (IL-7) is essential for the normal development and function lymphocytes. IL-7 plays pivotal role for activation and proliferation of T and B cells. The heterodimeric interleukin-7 receptor (IL-7R) is composed of the IL-7Rα (127) and the common cytokine receptor γc (CD132). The aim of this study was to evaluate the percentage of lymphocytes T (CD4(+) and CD8(+)) with IL-7R (CD127 and CD132) expression in hypertrophic adenoid in children suffering with otitis media with effusion for a duration of 3 months. Adenoid excised due to hypertrophy with or without chronic otitis media with effusion was used as study material. CD4(+) CD127(+), CD4(+)132(+), CD8(+)CD127(+) and CD8(+)CD132(+) cell subpopulations were identified using monoclonal antibodies and flow cytometry. The percentage of CD4(+) and CD8(+) T cells with CD127 receptor expression in hypertrophic adenoid of children with otitis media with effusion was statistically significantly higher than in hypertrophic adenoid group. The percentage of CD4(+) T cells with CD132 expression in the study group was statistically significantly higher than in the reference group. The percentage of CD8(+) T cells with CD132(+) expression was not statistically different in both groups. The increased percentage of T lymphocytes with IL-7R expression (CD127 and CD132) in hypertrophic adenoid seems to influence the quantity of lymphocytes and upset the immunological function of tonsils which can influence the course of otitis media with effusion.

  13. Adenoid and tonsil surgeries in children: How relevant is pre-operative blood grouping and cross-matching?

    Directory of Open Access Journals (Sweden)

    Lucky Onotai

    2013-01-01

    Full Text Available Background: As a part of pre-operative evaluation, several otolaryngologists group and cross-match blood routinely for children undergoing adenoid and tonsil surgeries. This practice has generated several debates either in support or against this practice. The aim of this study is to critically evaluate the incidence of post-tonsillectomy (with or without adenoidectomy bleeding and blood transfusions in otherwise healthy children with adenoid/tonsil pathologies conducted in the University of Port Harcourt Teaching Hospital (UPTH. Patients and Methods: A descriptive retrospective study of children who underwent adenoid and tonsil surgeries in the Department of Ear, Nose and Throat (ENT surgery of UPTH from January 2003 to December 2012. Children with family history of bleeding disorders and derangement of clotting profile as well as different co-morbidity like sickle cell disease were excluded from this study. The patients′ data were retrieved from the registers of ENT out-patient clinics, theatre registers and patients case notes. Demographic data, indications for surgery, preoperative investigations, complications and management outcomes were recorded and analyzed. Results: Out of 145 children that had adenoid and tonsil surgeries; only 100 met the criteria for this study. The study subjects included 65 males and 35 females (male: female ratio 1.9:1 belonging to 0-16 years age group (mean age: 3.46 ± 2.82 years. The age group of 3-5 years had the highest (n = 40, 40% number of surgeries. Adenotonsillectomy was the commonest (n = 85, 85% surgery performed on patients who had obstructive sleep apnea (OSA. The commonest (n = 6, 6% complication was haemorrhage, and only few (n = 3, 3% patients had blood transfusion. However, mortality was recorded in some (n = 3, 3% patients. Conclusion: This study confirms that the incidence of post adenoidectomy/tonsillectomy bleeding in otherwise healthy children is low and rarely requires blood transfusion

  14. ANTIMETASTATIC EFFECT OF INTEGRIN IIb/IIIa INHIBITORS ON SALIVARY ADENOID CYSTIC CARCINOMA

    Institute of Scientific and Technical Information of China (English)

    LI; Feng-he

    2001-01-01

    [1]Gasic GJ, Gasic TB, Stewart CC, et al. Antimetastatic effects associated with platelet reduction [J]. Proc Natl Acad Sci 1968; 61:46.[2]Gu YZ, Qiu WL, He RG, et al. An experimental study of the effects of aspirin on the adhesion of salivary adenoid cystic carcinoma cells [J]. Shanghai Stomatol 1999; 8:65.[3]Im SY, Ko HM, Ko JW, et al. Augmentation of tumor metastasis by platelet-activating factor [J]. Cancer Res 1996; 56:2262.[4]Tang DG, Onoda JM, Steinert BW. Phenotypic properties of cultured tumor cells: Integrin IIb/b 3 expression, tumor-cell-induced platelet aggrega-tion, and tumor cell adhesion to endothelium as an important parameters of experimental metastasis [J]. Int J Cancer 1993; 54:338.[5]Oleksowicz L, Mrowiec Z, Schwartz E, et al. Characterization of tumor-induced platelet aggregafion: The role of immunorelated GP IIb/IIIa expression by MCF-7 breast cancer cells [J]. Thromb Rest 1995; 79:261.[6]Nierodzik ML, Klepfish A, Karptkin S, et al. Role of platelet thrombin, integrin IIb-IIIa, fibronectin and von Willebrand factors on tumor adhesion in vitro and metastasis in vivo [J]. Thromb Haemost 1995; 74:282.[7]Guan Xiao-feng, Qiu Wei-liu, He Rong-gen, et al. The selection of a highly pulmonary metastatic cell line of salivary adenoid cystic carcinoma [J]. Chi J Stomatol 1996; 31:74.[8]Bhatti RA, Gadarowski J, Ray P, et al. Potential role of platelet and coagulation factors in the metastasis of prostatic cancer [J]. Invasion Metastasis 1996; 16:49.[9]Li Sheng-lin, Liu Xiu-Ping, Zhang Kui-hua. Establishment of a human salivary adenoid cystic carcinoma cell line and its characteristics [J]. Chi J Stomatol 1990; 25:29.[10]Chang HS, Yang RS, Huang TF. The Arg-Gly-Asp-containing peptide, rhodostomin, inhibits in vitro cell adhesion to extracellular matrices and platelet aggregation caused by Sao-2 human osteosarcoma cells [J]. Br J Cancer 1995; 71:265.[11]Karptkin S, Pearlstein E, Ambrogio C, et al. Role of adhesive

  15. Suprabasin Is Hypomethylated and Associated with Metastasis in Salivary Adenoid Cystic Carcinoma

    Science.gov (United States)

    Shao, Chunbo; Tan, Marietta; Bishop, Justin A.; Liu, Jia; Bai, Weiliang; Gaykalova, Daria A.; Ogawa, Takenori; Vikani, Ami R.; Agrawal, Yuri; Li, Ryan J.; Kim, Myoung Sook; Westra, William H.; Sidransky, David; Califano, Joseph A.; Ha, Patrick K.

    2012-01-01

    Background Salivary gland adenoid cystic carcinoma (ACC) is a rare cancer, accounting for only 1% of all head and neck malignancies. ACC is well known for perineural invasion and distant metastasis, but its underlying molecular mechanisms of carcinogenesis are still unclear. Principal Findings Here, we show that a novel oncogenic candidate, suprabasin (SBSN), plays important roles in maintaining the anchorage-independent and anchorage-dependent cell proliferation in ACC by using SBSN shRNA stably transfected ACC cell line clones. SBSN is also important in maintaining the invasive/metastatic capability in ACC by Matrigel invasion assay. More interestingly, SBSN transcription is significantly upregulated by DNA demethylation induced by 5-aza-2′-deoxycytidine plus trichostatin A treatment and the DNA methylation levels of the SBSN CpG island located in the second intron were validated to be significantly hypomethylated in primary ACC samples versus normal salivary gland tissues. Conclusions/Significance Taken together, these results support SBSN as novel oncogene candidate in ACC, and the methylation changes could be a promising biomarker for ACC. PMID:23144906

  16. Inhibitory Effects of Mistletoe Alkali on Salivary Adenoid Cystic Carcinoma Cells

    Institute of Scientific and Technical Information of China (English)

    LI Mei-hua; WANG Yi-shu; ZHOU Hong-lan; LI Ya-juan; QIU Xin-ru; WANG Xue-yao; ZHAO Yu-yang

    2013-01-01

    Mistletoe alkali plays an important role in salivary adenoid cystic carcinoma(SACC) cell proliferation,apoptosis and invasion.Mistletoe alkali shows potent anticaner property.In this paper,immunocytochemical and immunofluorescence staining were employed to evaluate the expression levels of proliferating cell nuclear antigen(PCNA),Caspase 3,Caspase 8 and Caspase 9.Apoptosis was detected by acridine orange/ethidium bromide (AO/EB) staining,cell invasion ability was assessed by Boyden Chamber assay.Pretreatment with mistletoe alkali markedly decreased PCNA expression in SACC cells in a dose-dependent manner(P<0.001) and also led to increase the expression of Caspase 3,Caspase 8 and Caspase 9 in SACC cells compared with control group(P<0.001).Number of apoptotic cells increased dramatically in mistletoe alkali group(P<0.001).In Boyden Chamber assay,mistletoe alkali treatment could inhibit SACC cells to penetrate the artificial basement membrane compared with control group(P<0.01).Mistletoe alkali remarkably inhibited the proliferation and invasion of SACC cells and induced the apoptosis of SACC cells.These results provide an insight into the mechanisms of anticancer effects of mistletoe alkali,and highlight the potential clinical application of it.

  17. Intracranial extension of adenoid cystic carcinoma of the palate: a case report

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    Oh, Yoon Kyeong; Kee, Keun Hong [College of Medicine, Chosun Univ., Kwangju (Korea, Republic of)

    1999-12-01

    Intracranial involvement by adenoid cystic carcinoma (ACC) is very rare and there is no report of intracranial extension from the palate ACC in Korea. Intracranial involvement can occur in one of three ways: direct extension, perineural spread, and hematogenous spread. A case report of a 35-year-old woman with intracranial ACC is presented. Initially she had ACC of the right palate and was treated by surgery and postoperative radiation therapy. Three years and 10 months later, the paresthesia in the distribution of ophthalmic and maxillary branch of right trigeminal nerve developed without evidence of recurrence in CT scan. Ptosis and total ophthalmoplegia developed sequentially and the second operation was performed. It was suggested that the tumor was spread perineurally along the trigeminal nerve into the Gasserian ganglion and then cavernous sinus and orbit. Seven years and 6 months after the first operation, direct intracranial extension into the right temporal lobe developed via sphenoid bone, sphenoid sinus and temporal bone and the third operation was done. And then Jung metastasis was diagnosed. She is alive for 9 years 5 months after first operation.

  18. Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1.

    Science.gov (United States)

    Fang, Jin; Bao, Yang-Yang; Zhou, Shui-Hong; Fan, Jun

    2015-11-01

    Apigenin is a natural phyto-oestrogen flavonoid, which exerts various biological effects, including anti‑oxidative, anti‑inflammatory and anticancer activities. In addition, apigenin has recently been reported to target hypoxic markers; however, there are currently no studies regarding the association between apigenin and glucose transporter‑1 (GLUT‑1) in adenoid cystic carcinoma (ACC). The present study investigated whether apigenin inhibits the proliferation of ACC cells or suppresses the expression of GLUT‑1 in ACC cells. The results of the present study demonstrated that apigenin inhibits ACC‑2 cell growth in a dose‑ and time‑dependent manner. Treatment with apigenin also induced apoptosis and G2/M‑phase arrest in a dose‑ and time‑dependent manner. Corresponding with the above results, the expression levels of GLUT‑1 were significantly decreased following treatment in a dose- and time-dependent manner. These results suggest that the inhibition of ACC-2 cell growth by apigenin may be due to the decreased expression of GLUT-1.

  19. Nasopharyngeal adenoid cystic carcinoma: magnetic resonance imaging features in ten cases

    Institute of Scientific and Technical Information of China (English)

    Xue-Wen Liu; Pei-Hong Wu; Chuan-Miao Xie; Hui Li; Rong Zhang; Zhi-Jun Geng; Yun-Xian Mo; Jing Zhao; Mu-Yan Cai; Yan-Chun Lv

    2012-01-01

    Nasopharyngeal adenoid cystic carcinoma (NACC) is a rare malignancy with high local invasiveness.To date,there is no consensus on the imaging characteristics of NACC.To address this,we retrospectively reviewed 10 cases of NACC and summarized the magnetic resonance imaging (MRI) features.MR images of 10 patients with histologically validated NACC were reviewed by two experienced radiologists.The location,shape,margin,signal intensity,lesion texture,contrast enhancement patterns,local invasion,and cervical lymphadenopathy of all tumors were evaluated.Clinical and pathologic records were also reviewed.No patients were positive for antibodies against Epstein-Barr virus (EBV).The imaging patterns of primary tumors were classified into two types as determined by location,shape,and margin.Of all patients,7 had tumors with a type 1 imaging pattern and 3 had tumors with a type 2 imaging pattern.The 4 tubular NACCs were all homogeneous tumors,whereas 3 (60%) of 5 cribriform NACCs and the sole solid NACC were heterogeneous tumors with separations or central necrosis on MR images.Five patients had perineural infiltration and intracranial involvement,and only 2 had cervical lymphadenopathy.Based on these results,we conclude that NACC is a local,aggressive neoplasm that is often negative for EBV infection and associated with a low incidence of cervical lymphadenopathy.Furthermore,MRI features of NACC vary in locations and histological subtypes.

  20. Effects of Genistein on Proliferation and Cell Cycle of Salivary Adenoid Cystic Carcinoma Cells

    Institute of Scientific and Technical Information of China (English)

    MA Jie; WANG Jie; ZHONG Ming; WANG Zhao-yuan

    2007-01-01

    Objective: To investigate the growth inhibiting effect of tyrosine protein kinase inhibitor, genistein, on human salivary adenoid cystic carcinoma SACC-83 cell line in vitro, and its effects on the expression of CyclinB1 protein and cell cycle. Methods: Effects of genistein on the growth of SACC-83 cells in vitro were measured with MTT assay. Cell cycle was detected with flow cytometry. The expressions of CyclinB1 and Cdk1 proteins were measured with Western blot method, and the results of protein expression were quantitatively analyzed by FluorChem V2.0 software. The results were statistically analyzed by SPSS11.5 software. Results: Genistein inhibited the cell proliferation in a dose-dependant and time-dependant manner. The genistein-treated SACC-83 cells were arrested in the G2/M phase and had lower contents of CyclinB1 and Cdk1 proteins compared with the control group. Conclusion: The growth inhibiting effect of genistein on SACC-83 cells may be associated with the regulations of genistein on the CyclinB1 and Cdk1 protein expressions and the cell cycle.

  1. Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma

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    Wuwei Li

    2014-01-01

    Full Text Available Adenoid cystic carcinoma (ACC is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs.

  2. Risk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china

    Science.gov (United States)

    Ouyang, Dai-qiao; Liang, Li-zhong; Zheng, Guang-sen; Ke, Zun-fu; Weng, De-sheng; Yang, Wei-fa; Su, Yu-xiong; Liao, Gui-qing

    2017-01-01

    Abstract Adenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and high incidence of distant metastasis (DM). The aim of this study was to evaluate predictive factors for local-regional (LR) recurrence, DM, and survival in ACC. A retrospective review of the medical records for patients with salivary glands ACC from 1990 to 2015 was performed. The clinical parameters were assessed to identify correlations with the development of LR recurrence, DM, and survival of these patients. Among 228 patients who underwent surgery as definitive treatment, 210 (92.1%) were followed up in the study. DM was detected in 64 (30.5%) patients, LR recurrence was detected in 58 (27.6%) patients. The estimated 5, 10, and 15-year overall survival rates were 84.7%, 70.8%, and 34.0%, respectively. Multivariate analysis revealed that the presence of lymphovascular invasion and a high T classification were very strong adverse factors, which independently influenced LR recurrence, DM, and survival of ACC patients. Positive/close margin and N+ status were independent risk factors for DM and LR recurrence, respectively. Survival of ACC patents was also affected by tumor location. Presence of lymphovascular invasion and a high T classification were very strong adverse factors and independent predictors for ACC patients’ prognosis, which influenced LR control, DM control, and survival. PMID:28151884

  3. Identification of intracellular bacteria in adenoid and tonsil tissue specimens: the efficiency of culture versus fluorescent in situ hybridization (FISH).

    Science.gov (United States)

    Stępińska, M; Olszewska-Sosińska, O; Lau-Dworak, M; Zielnik-Jurkiewicz, B; Trafny, E A

    2014-01-01

    Monocyte/macrophage cells from human nasopharyngeal lymphoid tissue can be a source of bacteria responsible for human chronic and recurrent upper respiratory tract infection. Detection and characterization of pathogens surviving intracellularly could be a key element in bacteriological diagnosis of the infections as well as in the study on interactions between bacteria and their host. The present study was undertaken to assess the possibility of isolation of viable bacteria from the cells expressing monocyte/macrophage marker CD14 in nasopharyngeal lymphoid tissue. Overall, 74 adenotonsillectomy specimens (adenoids and tonsils) from 37 children with adenoid hypertrophy and recurrent infections as well as 15 specimens from nine children with adenoid hypertrophy, which do not suffer from upper respiratory tract infections (the control group), were studied. The suitability of immunomagnetic separation for extraction of CD14(+) cells from lymphoid tissue and for further isolation of the intracellular pathogens has been shown. The coexistence of living pathogens including Haemophilus influenzae, Staphylococcus aureus, and Streptococcus pyogenes with the bacteria representing normal nasopharyngeal microbiota inside CD14(+) cells was demonstrated. Twenty-four strains of these pathogens from 32.4 % of the lysates of CD14(+) cells were isolated. Concurrently, the fluorescent in situ hybridization (FISH) with a universal EUB388, and the species-specific probes demonstrated twice more often the persistence of these bacterial species in the lysates of CD14(+) cells than conventional culture. Although the FISH technique appears to be more sensitive than traditional culture in the intracellular bacteria identification, the doubts on whether the bacteria are alive, and therefore, pathogenic would still exist without the strain cultivation.

  4. EXPRESSIONS OF P53, PROLIFERATING CELL NUCLEAR ANITIGEN, BCL-2 PROTEIN AND THEIR SIGNIFICANCE IN SALIVARY ADENOID CYSTIC CARCINOMA

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective To study the effects of P53, PCNA, Bcl-2 protein and their relationship in salivary adenoid cystic carcinoma(SACC). Methods These proteins were examined by immunohistochemistry. Results Overexpressions of P53 and PCNA were revealed in ACC samples, they were higher than those in (polymorphous adenomas) PA, but expression of Bcl-2 protein was not different between ACC and PA. In 3 subtypes of ACC, expressions of 3 proteins were different. Conclusion Mutations of P53, Bcl-2 may be involed in the occurrence of SACC, expression of PCNA and mutation of P53 may coexist in the development of the SACC.

  5. Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma

    Science.gov (United States)

    Shao, Chunbo; Sun, Wenyue; Tan, Marietta; Glazer, Chad A.; Bhan, Sheetal; Zhong, Xiaoli; Fakhry, Carole; Sharma, Rajni; Westra, William H.; Hoque, Mohammad O.; Moskaluk, Christopher A.; Sidransky, David; Califano, Joseph A.; Ha, Patrick K.

    2011-01-01

    Purpose Salivary gland adenoid cystic carcinoma (ACC) is a rare malignancy that is poorly understood. In order to look for relevant oncogene candidates under the control of promoter methylation, an integrated, genome-wide screen was performed. Experimental Design Global demethylation of normal salivary gland cell strains using 5-aza-2′-deoxycytidine (5-Aza dC) and Trichostatin A (TSA), followed by expression array analysis was performed. ACC-specific expression profiling was generated using expression microarray analysis of primary ACC and normal samples. Next, the two profiles were integrated to identify a subset of genes for further validation of promoter demethylation in ACC versus normal. Finally, promising candidates were further validated for mRNA, protein, and promoter methylation levels in larger ACC cohorts. Functional validation was then performed in cancer cell lines. Results We found 159 genes that were significantly re-expressed after 5-Aza dC/TSA treatment and overexpressed in ACC. After initial validation, eight candidates showed hypomethylation in ACC: AQP1, CECR1, C1QR1, CTAG2, P53AIP1, TDRD12, BEX1, and DYNLT3. Aquaporin 1 (AQP1) showed the most significant hypomethylation and was further validated. AQP1 hypomethylation in ACC was confirmed with two independent cohorts. Of note, there was significant overexpression of AQP1 in both mRNA and protein in the paraffin-embedded ACC cohort. Furthermore, AQP1 was up-regulated in 5-Aza dC/TSA treated SACC83. Lastly, AQP1 promoted cell proliferation and colony formation in SACC83. Conclusions Our integrated, genome-wide screening method proved to be an effective strategy for detecting novel oncogenes in ACC. AQP1 is a promising oncogene candidate for ACC and is transcriptionally regulated by promoter hypomethylation. PMID:21551254

  6. Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study

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    Khanfir, Kaouthar, E-mail: kaouthar.khanfir@rsv-gnw.ch [Hopital de Sion, CHCVs, Sion (Switzerland); Kallel, Adel [Institut Gustave Roussy, Villejuif (France); Villette, Sylviane [Centre Rene Huguenin, Paris (France); Belkacemi, Yazid [CHU Henri Mondor, Centre Oscar Lambret, Lille (France); Vautravers, Claire [Centre George Francois Leclerc, Dijon (France); Nguyen, TanDat [Institut Jean Gaudinot, Reims (France); Miller, Robert [Mayo Clinic, Rochester, Minnesota (United States); Li Yexiong [Peking Union Medical College, Beijing (China); Taghian, Alphonse G. [Massachusetts General Hospital, Boston, Massachusetts (United States); Boersma, Liesbeth [Maastricht University Medical Center (MAASTRO clinic), Maastricht (Netherlands); Poortmans, Philip [Dr. Bernard Verbeeten Institute, Tilburg (Netherlands); Goldberg, Hadassah [Western Galilee Hospital-Nahariya, Nahariya (Israel); Vees, Hansjorg [Hopitaux Universitaires de Geneve, Geneva (Switzerland); Senkus, Elzbieta [Medical University of Gdansk, Gdansk (Poland); Igdem, Sefik; Ozsahin, Mahmut [Istanbul Bilim University, Istanbul (Turkey); Jeanneret Sozzi, Wendy [Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)

    2012-04-01

    Background: Mammary adenoid cystic carcinoma (ACC) is a rare breast cancer. The aim of this retrospective study was to assess prognostic factors and patterns of failure, as well as the role of radiation therapy (RT), in ACC. Methods: Between January 1980 and December 2007, 61 women with breast ACC were treated at participating centers of the Rare Cancer Network. Surgery consisted of lumpectomy in 41 patients and mastectomy in 20 patients. There were 51(84%) stage pN0 and 10 stage cN0 (16%) patients. Postoperative RT was administered to 40 patients (35 after lumpectomy, 5 after mastectomy). Results: With a median follow-up of 79 months (range, 6-285), 5-year overall and disease-free survival rates were 94% (95% confidence interval [CI], 88%-100%) and 82% (95% CI, 71%-93%), respectively. The 5-year locoregional control (LRC) rate was 95% (95% CI, 89%-100%). Axillary lymph node dissection or sentinel node biopsy was performed in 84% of cases. All patients had stage pN0 disease. In univariate analysis, survival was not influenced by the type of surgery or the use of postoperative RT. The 5-year LRC rate was 100% in the mastectomy group versus 93% (95% CI, 83%-100%) in the breast-conserving surgery group, respectively (p = 0.16). For the breast-conserving surgery group, the use of RT significantly correlated with LRC (p = 0.03); the 5-year LRC rates were 95% (95% CI, 86%-100%) for the RT group versus 83% (95% CI, 54%-100%) for the group receiving no RT. No local failures occurred in patients with positive margins, all of whom received postoperative RT. Conclusion: Breast-conserving surgery is the treatment of choice for patients with ACC breast cancer. Axillary lymph node dissection or sentinel node biopsy might not be recommended. Postoperative RT should be proposed in the case of breast-conserving surgery.

  7. Reactive oxygen species and autophagy associated apoptosis and limitation of clonogenic survival induced by zoledronic acid in salivary adenoid cystic carcinoma cell line SACC-83.

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    Xi-Yuan Ge

    Full Text Available Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites. Zoledronic acid, a third generation bisphosphonate, has been used for tumor-induced osteolysis due to bone metastasis and has direct antitumor activity in several human neoplasms. Here, we observed that zoledronic acid inhibited salivary adenoid cystic carcinoma cell line SACC-83 xenograft tumor growth in nude mice. In vitro, zoledronic acid induced apoptosis and reduced clonogenic survival in SACC-83. Flow cytometry and western blotting indicated that the cell cycle was arrested at G0/G1. Zoledronic acid treatment upregulated reactive oxygen species as well as the autophagy marker protein LC-3B. Reactive oxygen species scavenger N-acetylcysteine and autophagy antagonist 3-methyladenine decreased zoledronic acid-induced apoptosis and increased clonogenic survival. Silencing of the autophagy related gene Beclin-1 also decreased zoledronic acid-induced apoptosis and inhibition of clonogenic formation. In addition, isobolographic analysis revealed synergistic effects on apoptosis when zoledronic acid and paclitaxel/cisplatin were combined. Taken together, our results suggest that zoledronic acid induced apoptosis and reduced clonogenic survival via upregulation of reactive oxygen species and autophagy in the SACC-83 cell line. Thus, zoledronic acid should be considered a promising drug for the treatment of salivary adenoid cystic carcinoma.

  8. Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy

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    Bahadir Osman

    2008-01-01

    Full Text Available Adenoid cystic carcinoma of the parotid gland is a rare and slowly growing, but highly malignant tumor. Surgical resection of a malignant parotid tumor should include resection of the facial nerve when the nerve is involved in the tumor. Facial nerve reconstruction is required after nerve resection. A 14 year-old female presented with complaints of painless enlargement of the right parotid gland and facial asymmetry. Physical examination revealed a firm mass in the region of the parotid gland as well as right facial paralysis. Biopsy obtained from the mass showed an adenoid cystic carcinoma of the parotid gland. A radical parotidectomy with a modified radical neck dissection was carried out. Grafting material for the facial reconstruction was harvested from the great auricular nerve. The proximal main trunk and each distal branch of the facial nerve were coapted with the greater auricular nerve. The patient received radiotherapy after surgery and was seen to achieve grade IV facial function one year after surgery. Thus, the great auricular nerve is appropriate grafting material for coaptation of each distal branch of the facial nerve.

  9. Hybrid Carcinoma of the Larynx: A Case Report (Adenoid Cystic and Adenocarcinoma and Review of the Literature

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    Ilias Karasmanis

    2013-01-01

    Full Text Available Introduction. The nonsquamous carcinomas of the larynx are considered rare with the majority of malignant tumors in this area, reaching the rate of 95%, to be squamous cell neoplasms. Case Report. The case refers to a 53-year-old man that presented with symptomatology of motor nerve disease. During the evaluation of the neurologic disease, a subglottic mass of the larynx was revealed accidentally in the imaging examination. Under general anesthesia, we performed direct laryngoscopy and biopsy of the mass. The histopathologic examination revealed a hybrid carcinoma coexistence of two different carcinomas, an adenoid cystic carcinoma and an adenocarcinoma, not otherwise specified with poor differentiation. Regarding the therapeutic plan, the mass was considered inoperable due to its expansion to trachea and the patient received radiotherapy. Conclusions. Both the adenocarcinoma and adenoid cystic carcinoma are extremely rare types of malignant tumors in the larynx. The special interest of the present case is the coexistence of these two rare tumors in the same region of the larynx, being a hybrid tumor of the salivary glands in the larynx, which is the second reported case, based on our systematic literature review.

  10. Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses

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    Müller-Hermelink Hans-Konrad

    2009-06-01

    Full Text Available Abstract Background Adenoid cystic carcinomas are rare tumors with an indolent clinical course, but frequent local relapses. The identification of tumors with a higher relapse risk seems to be interesting. Hence we investigated parameters of glucose metabolism, which were found associated with poor prognosis in other malignancies. Methods Specimen of 29 patients were investigated immunohistochemically with antibodies against p-AKT, TKTL-1 (transketolase-like 1, M2PK (M2 pyruvate kinase, and GLUT-1. Proliferation was investigated by staining with Ki67. The tumors were located at the major or minor salivary glands. Only the typical cribriform subtype was investigated. The initial tumor stage was pT1 or pT2. Results Expression of p-AKT was significantly (P = 0.036 associated with a higher relapse risk in multivariate analysis. Low expression of M2PK was non-significantly (P = 0.065 predictive for a higher risk. TKTL-1 and GLUT-1 were expressed in the majority of cases, albeit not associated with relapse risk. Conclusion Adenoid cystic carcinomas positive for p-AKT show a higher relapse risk. However, other parameters of glucose metabolism investigated here or proliferation (Ki67 were not predictive in this entity. Our findings demonstrate a possible background for therapeutic approaches targeting the inhibition of PI3K/AKT pathway.

  11. A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi

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    K Sharma

    2010-01-01

    Full Text Available Context: Adenoid cystic carcinoma (ACC is a rare neoplasm that usually arises from the salivary, lacrimal, or other exocrine glands. It is characteristically locally infiltrative in nature and has a tendency toward local recurrence, high propensity for perineural invasion, and prolonged clinical course. Aim: To analyze the presentation and natural history of cases of adenoid cystic tumors of salivary glands in our institution; and to compare with the existing literature. Design and Setting: Retrospective study at the Department of Radiotherapy. Materials and Methods: Data on 18 patients of ACC of the salivary glands treated between 2004 and 2008 were reviewed with respect to clinical presentation, stage, and histology. Results: There were 8 cases of major salivary gland tumors (47%, of which 2 were in the submandibular and 6 were involving the parotid. Ten patients (53% had minor salivary gland involvement. Two patients had metastasis at the time of presentation. All patients underwent surgery. Radiotherapy was delivered to 16 patients and chemotherapy to 6 patients (concurrent, n = 3 and adjuvant, n = 3 and no adjuvant therapy was given to 2 patients. All patients were alive at a median follow-up of 3 years. No patient developed local or distant failure during the study duration. Conclusion: ACC has locally aggressive behavior. Radiotherapy adjuvant to surgery improves local control in locally advanced disease. Longer follow-up is mandatory in view of incidence of late metastasis.

  12. Synergistic effect of nanosecond pulsed electric field combined with low-dose of pingyangmycin on salivary adenoid cystic carcinoma.

    Science.gov (United States)

    Qi, Wei; Guo, Jinsong; Wu, Shan; Su, Bo; Zhang, Lei; Pan, Jie; Zhang, Jue

    2014-05-01

    Adenoid cystic carcinoma (ACC) is one of the most common malignant neoplasms in salivary glands. To evaluate the therapeutic effects of nanosecond pulsed electric field (nsPEF) combined with pingyangmycin (PYM) on salivary gland adenoid cystic carcinoma (SACC), ACC high metastatic cell line (SACC-LM) and low metastatic cell line (SACC‑83) were tested by CCK-8 assay, cell clonogenic assay, flow cytometry and Transwell assay. Extracellular matrix metalloproteinase inducer (EMMPRIN) expression was tested by western blotting to verify the synergistic mechanism of nsPEF and PYM. The results showed that nsPEF inhibited the cell proliferation of both cell lines, and the inhibitory effect was strongly associated with time and electrical field strength. Moreover, PYM combined with nsPEF may enhance the suppression effect significantly, even at a very low dose (0.01 µg/ml). The synergistic effects may contribute to the downregulation of EMMPRIN expression resulting from the application of nsPEF. For SACC, nsPEF combined with chemotherapy agents may be a valuable strategy not only to improve the treatment effect and prognosis, but also to reduce the side-effects of chemotherapy.

  13. Prevalence of Panton-Valentine leucocidin and phenotypic and genotypic characterization of biofilm formation among Staphylococcus aureus strains isolated from children with adenoid hypertrophy.

    Science.gov (United States)

    Emaneini, Mohammad; Khoramrooz, Seyed Sajjad; Shahsavan, Shadi; Dabiri, Hossein; Jabalameli, Fereshteh

    2015-12-01

    Adenoids as a first line of host defense against respiratory microbes play an important role in majority of upper airway infectious and noninfectious illnesses. Bacterial pathogen can colonize on the adenoid tissue and probably act as a reservoir for them. To determine phenotypic and genotypic characterization of biofilm forming capacity of Staphylococcus aureus isolates from children with adenoid hypertrophy and prevalence of Panton-Valentine leukocidin (PVL) gene we collected 17 consecutive, clinically significant S. aureus isolates from children with adenoid hypertrophy undergoing adenoidectomy with one or more of the upper airway obstruction symptoms, nasal obstruction, mouth breathing, snoring, or sleep apnea. Biofilm formation was evaluated by colorimetric microtiter plate's assay. Gene encoding PVL and adhesion- or biofilm formation-encoding genes were targeted by polymerase chain reaction (PCR) assay. According to the results, all strains produced biofilm. Seven (41.2%) isolates produced strong biofilm whereas 7 (41.2%) isolates produced week and 3 (17.6%) isolates produced medium biofilm. Regarding the adhesion- or biofilm formation-encoding genes, 16 (94.1%) isolates were positive for the gene eno, 13(76.4%) for icaA, 13 (76.4%) for icaD, 10 (58.8%) for fib, 10 (58.8%) for fnbB, 4(23.5%) for can, and 1(5.8%) for fnbA. The high prevalence of genes encoding biofilms and adhesins and phenotypic ability to form a biofilm by S. aureus strains emphasizes the pathogenic character of strains isolated from children with adenoid hypertrophy.

  14. Cephalometric evaluation of adenoids, upper airway, maxilla, velum length, need ratio for determining velopharyngeal incompetency in subjects with unilateral cleft lip and palate

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    Avinash Gohilot

    2014-01-01

    Full Text Available Objectives: Children with cleft lip and palate (CLP are seen to have reduced airway size and large adenoids, which might lead to different characteristics in the upper airway and surrounding tissues from both morphological and functional perspectives. Decrease in adenoid size and increase in need ratio in cleft patients might lead to velopharyngeal incompetency (VPI and development of nasality in adulthood. No studies have been conducted on the Indian population with variables contributing to VPI. So the aim was to evaluate the size and position of the adenoids, upper airway, maxilla, velum length and need ratio contributing to VPI in subjects with and without unilateral cleft lip and palate (UCLP during juvenile and adolescent stages. Materials and Methods: Cephalograms of 120 subjects with 6-17 years were taken and various linear and angular measurements were measured and data was analyzed using the unpaired t test. Results: Adenoids were significantly larger and the upper airway smaller in the juvenile and adolescent cleft group than in the non-cleft group. In the adolescent cleft group, airway was larger than that in the adolescent non-cleft group. The maxilla was small and retropositioned in juvenile and adolescent subjects as compared to non cleft cases. Length of velum was smaller and need ratio was larger in both juvenile and adolescent groups as compared to the non-cleft group, suggestive of velopharyngeal incompetence. Conclusion: Decreased Adenoids, restricted airway, small, retruded maxilla, smaller velum length and larger need ratio larger were seen in the cleft group as compared to the non-cleft group, which was suggestive of VPI.

  15. Nomograms for predicting survival and recurrence in patients with adenoid cystic carcinoma. An international collaborative study

    Science.gov (United States)

    Ganly, Ian; Amit, Moran; Kou, Lei; Palmer, Frank L.; Migliacci, Jocelyn; Katabi, Nora; Yu, Changhong; Kattan, Michael W.; Binenbaum, Yoav; Sharma, Kanika; Naomi, Ramer; Abib, Agbetoba; Miles, Brett; Yang, Xinjie; Lei, Delin; Bjoerndal, Kristine; Godballe, Christian; Mücke, Thomas; Wolff, Klaus-Dietrich; Fliss, Dan; Eckardt, André M.; Chiara, Copelli; Sesenna, Enrico; Ali, Safina; Czerwonka, Lukas; Goldstein, David P.; Gil, Ziv; Patel, Snehal G.

    2016-01-01

    Background Due to the rarity of adenoid cystic carcinoma (ACC), information on outcome is based upon small retrospective case series. The aim of our study was to create a large multiinstitutional international dataset of patients with ACC in order to design predictive nomograms for outcome. Methods ACC patients managed at 10 international centers were identified. Patient, tumor, and treatment characteristics were recorded and an international collaborative dataset created. Multivariable competing risk models were then built to predict the 10 year recurrence free probability (RFP), distant recurrence free probability (DRFP), overall survival (OS) and cancer specific mortality (CSM). All predictors of interest were added in the starting full models before selection, including age, gender, tumor site, clinical T stage, perineural invasion, margin status, pathologic N-status, and M-status. Stepdown method was used in model selection to choose predictive variables. An external dataset of 99 patients from 2 other institutions was used to validate the nomograms. Findings Of 438 ACC patients, 27.2% (119/438) died from ACC and 38.8% (170/438) died of other causes. Median follow-up was 56 months (range 1–306). The nomogram for OS had 7 variables (age, gender, clinical T stage, tumor site, margin status, pathologic N-status and M-status) with a concordance index (CI) of 0.71. The nomogram for CSM had the same variables, except margin status, with a concordance index (CI) of 0.70. The nomogram for RFP had 7 variables (age, gender, clinical T stage, tumor site, margin status, pathologic N status and perineural invasion) (CI 0.66). The nomogram for DRFP had 6 variables (gender, clinical T stage, tumor site, pathologic N-status, perineural invasion and margin status) (CI 0.64). Concordance index for the external validation set were 0.76, 0.72, 0.67 and 0.70 respectively. Interpretation Using an international collaborative database we have created the first nomograms which

  16. 腺样体肥大与食物不耐受相关性探讨%The discussion on relationship between adenoids hypertrophy and food intolerance

    Institute of Scientific and Technical Information of China (English)

    李雅琼; 孙捷; 张华

    2013-01-01

    目的:探讨食物不耐受与腺样体肥大的关系,为预防腺样体肥大提供依据.方法:收集腺样体肥大患儿111例作为腺样体肥大组,无过敏史、过敏相关性疾病及腺样体肥大症状的患儿30例作为对照组,对两组患儿食物不耐受的结果进行比较.结果:①腺样体肥大组食物不耐受检出的阳性率高于对照组(P<0.01).②两组患儿在食物不耐受各个程度上的分布是不相同的.③腺样体肥大与患儿究竟有几种高、中度不耐受的食物无关.④日常食用的14种食物中,腺样体肥大组与对照组排在前三位的食物均为蛋类、奶类和鳕鱼.结论:食物不耐受是引起腺样体肥大的可能病因之一;食物特异性IgG抗体的检测在预防腺样体肥大中具有积极的意义.%Objective:To explore the relationship between food intolerance and adenoidal hypertrophy and accordingly to provide evidence for intolerance and adenoidal hypertrophy.Method:Adenoidal hypertrophy in patients with a total of 111 cases as the experiment group,30 cases of children with no history of allergies and allergy-related diseases and adenoidal hypertrophy symptoms as the control group,and compared the result of food intolerance between two groups.Result:①Food intolerance detected positive rate of adenoidal hypertrophy group was higher than the control group.②The distribution of the two groups of children in the extent of food intolerance is different.③Adenoid hypertrophy and how many types of the food,which is high,moderate intolerance,are unrelated.④The daily consumption of 14 kinds of food,the top three foods of adenoidal hypertrophy group and control group are eggs,milk,cod.Conclusion:Food intolerance is the possible cause of adenoidal hypertrophy.The detection of specific IgG antibodies of food have positive significance in the prevention of adenoidal hypertrophy.

  17. Nasopharyngeal and Adenoid Colonization by Haemophilus influenzae and Haemophilus parainfluenzae in Children Undergoing Adenoidectomy and the Ability of Bacterial Isolates to Biofilm Production.

    Science.gov (United States)

    Kosikowska, Urszula; Korona-Głowniak, Izabela; Niedzielski, Artur; Malm, Anna

    2015-05-01

    Haemophili are pathogenic or opportunistic bacteria often colonizing the upper respiratory tract mucosa. The prevalence of Haemophilus influenzae (with serotypes distribution), and H. parainfluenzae in the nasopharynx and/or the adenoid core in children with recurrent pharyngotonsillitis undergoing adenoidectomy was assessed. Haemophili isolates were investigated for their ability to biofilm production.Nasopharyngeal swabs and the adenoid core were collected from 164 children who underwent adenoidectomy (2-5 years old). Bacteria were identified by the standard methods. Serotyping of H. influenzae was performed using polyclonal and monoclonal antisera. Biofilm formation was detected spectrophotometrically using 96-well microplates and 0.1% crystal violet.Ninety seven percent (159/164) children who underwent adenoidectomy were colonized by Haemophilus spp. The adenoid core was colonized in 99.4% (158/159) children, whereas the nasopharynx in 47.2% (75/159) children (P influenzae were identified, in 22.6% (36/159) children only (nonencapsulated) H. influenzae NTHi (nonencapsulated) isolates were present, whereas 7.5% (12/159) children were colonized by both types. 14.5% (23/159) children were colonized by untypeable (rough) H. influenzae. In 22% (35/159) children H. influenzae serotype d was isolated. Totally, 192 isolates of H. influenzae, 96 isolates of H. parainfluenzae and 14 isolates of other Haemophilus spp. were selected. In 20.1% (32/159) children 2 or 3 phenotypically different isolates of the same species (H. influenzae or H. parainfluenzae) or serotypes (H. influenzae) were identified in 1 child. 67.2% (129/192) isolates of H. influenzae, 56.3% (54/96) isolates of H. parainfluenzae and 85.7% (12/14) isolates of other Haemophilus spp. were positive for biofilm production. Statistically significant differences (P = 0.0029) among H. parainfluenzae biofilm producers and nonproducers in the adenoid core and the nasopharynx were detected.H. influenzae and H

  18. Auriscopy in the diagnosis of adenoid hypertrophy in children%耳内镜在小儿腺样体肥大诊治中的应用

    Institute of Scientific and Technical Information of China (English)

    梁敏婷

    2010-01-01

    Objective To explore the application of auriscopic nose- nasopharyngeal examina tion in the diagnosis and treatment of adenoid hypertrophy in children. Methods Auriscopic nose-na sopharyngeal examination was performed in 412 children with the symptoms of upper airway obstruction to explore the relationship between the degree of adenoid enlargement and upper airway obstruction. Results The procedure was successfully performed in 395 of 412 children. Of the 395 children, 358 had adenoid hypertrophy, 14 had choanal polyp, 16 has allergic rhinitis, and the remaining 7 had chronic rhinitis. Accord ing to the degree of rear nasal passage blockage, in 358 children with adenoid hypertrophy, 43 (12%) was grade Ⅰ, 97 (27%) was Ⅱ, 103 (28.8%) was Ⅲ, and 115 (32.2%) was Ⅳ. Conclusions Auriscopic nose nasopharyngeal examination is an ideal procedure for nasopharyngeal adenoid hypertrophy in children. It is directly visual, accurate, and safe. Grade Ⅳ adenoids is the main etiology of upper airway obstruction in children, which is the indication of surgical treatment.%目的 探讨耳内镜下鼻-鼻咽检查在小儿腺样体肥大诊治中的应用.方法 对412例具有上气道阻塞症状的患儿采用耳内镜进行鼻-鼻咽检查,分析腺样体增大程度与上气道阻塞的关系及其可行性.结果 412例中395例完成检查(17例因患儿哭闹,不能配合检查). 395例单纯诊断性检查:腺样体肥大358例,后鼻孔息肉14例,过敏性鼻炎16例,慢性鼻炎7例.358例腺样体肥大病例中,根据腺样体阻塞后鼻孔的情况分为:Ⅰ级43例(12%),Ⅱ级97例(27%),Ⅲ级103例(28.8%),Ⅳ级115例(32.2%).结论耳内镜鼻-鼻咽检查适合于小儿腺样体肥大检查,该法直观、准确、安全,是判断小儿腺样体肥大有效、直观的检查方法.Ⅳ级腺样体是小儿上气道阻塞的主要病因,是手术治疗的适应证.

  19. [Sinonasal cystic adenoid carcinoma with epiphora and orbital involvement. Report of a case and review of the literature].

    Science.gov (United States)

    Pino Rivero, V; González Palomino, A; Pantoja Hernández, C G; Marcos García, M; Trinidad Ruiz, G; Pardo Romero, G; Blasco Huelva, A

    2005-01-01

    We report the clinical case of a 41 years old male with nasal obstruction of 1 year, epistaxis and epiphora. The ENT exam showed a bleeding red mass in left nasal fossa and CT joint to IRM revealed a tumoral process on that level and informed about its extension to adyacents structures (cavum, ethmoides, sphenoids and maxillary sinus). The biopsy was positive for cystic adenoid carcinoma. Our patient was operated by paralateronasal rhinotomy with removal of the tumor. One year later we found recurrence on the left orbital floor and maxilar sinus. The Oncology Department informed that it was not possible a treatment with radiotherapy or chemotherapy because the low sensitivity of that lesion those treatment.

  20. A Case of Dermal Adenoid Squamous Cell Carcinoma%皮肤腺样鳞癌1例

    Institute of Scientific and Technical Information of China (English)

    郑兴征; 潘晓琳; 陈云昭; 胡文浩

    2003-01-01

    @@ 腺样鳞癌(Adenoid Squamous Cell Carcinoma,ASCC),又称假血管肉瘤样癌(Pseudoangiosarcomatous Carcinoma)是鳞状细胞癌中的一种特殊的组织学类型,多见于老年人,且主要发生于头颈部或皮肤暴露区,有少数外阴部的病例报道.本文报道一例腹股沟区发生的皮肤腺样鳞癌病例,复习并探讨该肿瘤的病变特点与诊断依据.

  1. Carcinoma adenoide quístico parotídeo: soluciones estéticas y funcionales

    Directory of Open Access Journals (Sweden)

    Raquel Villar

    2014-07-01

    Full Text Available El carcinoma adenoide quístico supone el 10-30% de las neoplasias malignas parotídeas, su tratamiento se basa en una parotidectomía que incluya el tumor con un adecuado margen de seguridad y la radioterapia postoperatoria dado que permite mejorar el control locorregional de la enfermedad. Revisamos un caso que permite exponer el manejo de las secuelas funcionales y estéticas derivadas de su tratamiento. Consideramos adecuada la reconstrucción inmediata del nervio facial cuando se encuentra clínicamente afecto o englobado por el tumor; así como suplir el defecto de volumen posparotidectomía con un colgajo local. Proponemos la anastomosis nerviosa con injerto de nervio sural de las ramas del nervio facial afectas y el relleno del defecto volumen posparotidectomía con un colgajo de fascia temporo-parietal.

  2. An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study

    Directory of Open Access Journals (Sweden)

    Morris Pierre A

    2007-08-01

    Full Text Available Abstract Background Adenoid Cystic Carcinoma (ACC is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence rate. Intracranial ACC is even more infrequent and could be primary or secondary occurring either by direct invasion, hematogenous spread, or perineural spread. We report the first case of the 5th and 6th nerve palsy due to cavernous sinus invasion by adenoid cystic carcinoma. Case presentation A 49-year-old African American female presented to the emergency room complaining of severe right-sided headache, photophobia, dizziness and nausea, with diplopia. The patient had a 14 year history migraine headaches, hypertension, and mild intermittent asthma. Physical examination revealed right lateral rectus muscle palsy with esotropia. There was numbness in all three divisions of the right trigeminal nerve. Motor and sensory examination of extremities was normal. An MRI of the brain/brain stem was obtained which showed a large mass in the clivus extending to involve the nasopharynx, pterygoid plate, sphenoid and right cavernous sinuses. Biopsy showed an ACC tumor with a cribriform pattern of the minor salivary glands. The patient underwent total gross surgical resection and radiation therapy. Conclusion This is a case of ACC of the minor salivary glands with intracranial invasion. The patient had long history of headaches which changed in character during the past year, and symptoms of acute 5th and 6th cranial nerve involvement. Our unique case demonstrates direct invasion of cavernous sinus and could explain the 5th and 6th cranial nerve involvement as histopathology revealed no perineural invasion.

  3. Analysis of upper airway cough syndrome caused by adenoidal hypertrophy and adenoiditis in children%儿童腺样体肥大和腺样体炎所致上气道咳嗽综合征的临床特点探讨

    Institute of Scientific and Technical Information of China (English)

    谷庆隆; 高帆; 陈育智; 庞冲; 刘晨; 陆颖霞; 黄春雷; 赵晶

    2011-01-01

    目的 了解儿童腺样体肥大和腺样体炎所致上气道咳嗽综合征(UACS)的临床特点和诊断要点.方法 从哮喘中心转到耳鼻咽喉科会诊的慢性咳嗽患儿中,对确诊为UACS的患儿进行研究,分析UACS患儿中腺样体肥大和腺样体炎的临床特点.结果 238例患儿中,诊断为UACS患儿有149例,其中88例(59.1%)患儿伴有腺样体肥大或炎症,包括腺样体肥大67例和慢性腺样体炎21例.对伴腺样体肥大和伴腺样体炎的UACS各种临床表现进行比较,鼻炎相关症状和口咽腔可见脓性分泌物在伴腺样体肥大的UACS患儿中发生率较高(x2值分别为32.71和17.08,P值均小于0.01).体位变化咳嗽对诊断伴腺样体肥大的UACS以及伴腺样体炎的UACS敏感度(分别为80.6%和76.2%)、特异度(分别为63.2%和53.5%)以及阴性预测值(分别为89.3%和95.9%)都较高,但阳性预测值较低(分别为46.2%和13.7%).睡眠打鼾、鼻炎相关症状以及口咽腔见脓性分泌物倒流对诊断伴腺样体肥大UACS的敏感度(分别为67.2%、82.1%和61.2%)和阴性预测值(分别为87.8%、86.2%和83.2%)均较高,并且睡眠打鼾的特异度亦较高(92.4%).结论 UACS患儿中以腺样体肥大和腺样体炎为病因的比例较高,并且易于漏诊,体位变化性咳嗽对诊断有较高的敏感性和特异性.%Objective To understand the clinical characteristics and diagnostic points of upper airway cough syndrome (UACS) caused by adenoidal hypertrophy and adenoiditis in children. Method We analyzed the clinical characteristics of the patients with adenoidal hyertrotrophy and adenoiditis in the children with UACS, who were transferred from the asthma center to consult. Results Among 238 cases, 149 patients were diagnosed as UACS, in which 88 cases (59.1%) were associated with adenoidal hypertrophy or adenoiditis. Among the 88 cases, there were 67 cases with adenoid hypertrophy and 21 cases with adenoiditis. To

  4. Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma.

    Science.gov (United States)

    Fang, Jin; Bao, Yang-Yang; Zhou, Shui-Hong; Luo, Xing-Mei; Yao, Hong-Tian; He, Jian-Feng; Wang, Qin-Ying

    2012-12-01

    The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence.

  5. Double hairpin elements and tandem repeats in the non-coding region of Adenoides eludens chloroplast gene minicircles.

    Science.gov (United States)

    Nelson, Martha J; Green, Beverley R

    2005-09-26

    Dinoflagellate plastid genomes are unique in having a reduced number of genes, most of which are found on unigenic minicircles of 2-3 kb. Although the dinoflagellate Adenoides eludens has larger minicircles of about 5 kb, they still carry only one gene. In addition, digenic circles of about 10 kb were detected and mapped by PCR. The non-coding regions of both unigenic and digenic circles share a number of common features including a pair of conserved cores in opposite orientation, four large families of tandem repeats and a number of double hairpin elements (DHEs). They most closely resemble the non-coding regions of the Symbiodinium psbA minicircles, but are much longer, less conserved and have an even greater variety of DHEs and tandem repeats. The presence of so many recombinogenic elements suggests models for the origin of minicircles from a multigenic ancestral chloroplast genome, and raises the possibility of recombination-directed replication rather than defined replication origins in the minicircles.

  6. Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands.

    Science.gov (United States)

    de Souza, Lélia Batista; de Oliveira, Lucileide Castro; Nonaka, Cassiano Francisco Weege; Lopes, Maria Luiza Diniz de Sousa; Pinto, Leão Pereira; Queiroz, Lélia Maria Guedes

    2017-03-16

    This study aimed to evaluate and compare the immunoexpression of glucose transporter-1 (GLUT-1) and angiogenic index between pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs), and mucoepidermoid carcinomas (MECs) of the salivary glands, and establish associations with the respective subtype/histological grade. Twenty PAs, 20 ACCs, and 10 MECs were submitted to morphological and immunohistochemical analysis. GLUT-1 expression was semi-quantitatively evaluated and angiogenic index was assessed by microvessel counts using anti-CD34 antibody. Higher GLUT-1 immunoexpression was observed in the MECs compared to PAs and ACCs (p = 0.022). Mean number of microvessels was 66.5 in MECs, 40.4 in PAs, and 21.2 in ACCs (p GLUT-1 expression and angiogenic index showed no significant correlation in the tumors studied. Results suggest that differences in biological behavior of the studied tumors are related to GLUT-1. Benign and malignant salivary gland tumors differ in the angiogenic index; however, angiogenesis may be independent of the tumor cell's metabolic demand.

  7. {sup 125}I brachytherapy alone for recurrent or locally advanced adenoid cystic carcinoma of the oral and maxillofacial region

    Energy Technology Data Exchange (ETDEWEB)

    Huang, M.W.; Zheng, L.; Liu, S.M.; Shi, Y.; Zhang, J.; Yu, G.Y.; Zhang, J.G. [Peking Univ. School and Hospital of Stomatology, Beijing (China). Dept. of Oral and Maxillofacial Surgery

    2013-06-15

    Background and purpose: This retrospective study was to evaluate the local control and survival of {sup 125}I brachytherapy for recurrent and/or locally advanced adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. Patients and methods: A total of 38 patients with recurrent and/or locally advanced ACC of the oral and maxillofacial region received {sup 125}I brachytherapy alone from 2001-2010. Twenty-nine were recurrent cases following previous surgery and radiation therapy. The other 9 cases involved primary tumors. Overall, 12 tumors were located in the major salivary glands, 12 in the minor salivary glands, and 14 in the paranasal region, the nasal cavity or the skull base. The prescribed dose was 100-160 Gy. Results: Patients were followed for 12-122 months (median 51 months). The 2-, 5-, and 10-year local tumor control rates were 86.3, 59, and 31.5 %, respectively. The 2-, 5-, and 10-year overall survival rates were 92.1, 65 and 34.1 %, respectively. Tumors > 6 cm had significantly lower local control and survival rates. No severe complications were observed during follow-up. Conclusion: {sup 125}I brachytherapy is a feasible and effective modality for the treatment of locally advanced unresectable or recurrent ACC. (orig.)

  8. Adenoid cystic carcinoma of head and neck: A single institutional analysis of 66 patients treated with multi-modality approach

    Directory of Open Access Journals (Sweden)

    Ajeet Kumar Gandhi

    2015-01-01

    Full Text Available Background: Adenoid cystic carcinoma (ACC accounts for 1% of all head and neck (HN cancers. Materials and Methods: Demographic, clinical, treatment, and survival details of 66 patients were collected (1995-2011 and analyzed. Disease-free survival (DFS was estimated by Kaplan-Meier method. Results: Primary disease sites were sinonasal (n = 27, salivary gland (n = 30, and others (n = 9. Median follow-up was 23 months (range: 12-211 months. Estimated DFS at 2- and 5-year were 75% and 67.2%, respectively. On univariate analysis, intra-cranial extension (ICE (hazard ratio [HR]: 3.59, P = 0.0071, lymph node involvement (HR: 4.05, P = 0.0065, treatment modality (others vs. surgery plus adjuvant radiotherapy, HR: 2.39, P = 0.0286 and T stage (T3/4 vs. T1/2, HR: 3.27, P = 0.007 had significant impact on DFS. Lymph node involvement (P = 0.038 and ICE (P = 0.038 continued to have significant impact on DFS on multivariate analysis. Conclusion: Surgery followed by adjuvant radiotherapy remains the treatment of choice for HN ACC. Lymph node involvement and ICE confer poor prognosis.

  9. Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis

    Directory of Open Access Journals (Sweden)

    Zhou Quan

    2012-09-01

    Full Text Available Abstract Objectives This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis. Methods A retrospective study of 80 ACC patients was performed. Clinical data were collected, and p63, CD117 were detected by immunohistochemical staining. Results Eighty patients received follow-ups 3 to 216 months after initial diagnosis. ACC occurred in the lacrimal gland (26.3%, n = 21, nasal cavity and parasinus (33.8%, n = 27 and other sites (40.0%, n = 33. The 5-year and 10-year survival rates were 66.41% and 10.16%, respectively. Over expression of CD117 was detected in p63-negative cells in 94.3% of cases and in p63-positive cells in 45.8%. The expression of CD117 in p63-positive cells was significantly associated with the histological grade (P Conclusions ACC had a good 5-year survival but poor 10-year survival in Chinese, which differed from the occidental data. More p63+/CD117+ cells were associated with a higher histological grade and poorer outcome. Virtual slides The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1701457278762097

  10. Effects of 5-aza-2′deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, X.Q. [Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan (China); Department of Oral and Maxillofacial Surgery, The First People' s Hospital of Jining, Shandong (China); Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan (China); Huang, S.Y. [Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan (China); Zhang, D.S. [Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan (China); Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan (China); Zhang, S.Z.; Li, W.G.; Chen, Z.W.; Wu, H.W. [Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan (China)

    2014-12-12

    Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene that negatively regulates matrix metalloproteinases (MMPs), is expressed in various normal human tissues but downregulated in several types of human tumors. The molecular mechanism for this downregulation and its biological significance in salivary adenoid cystic carcinoma (SACC) are unclear. In the present study, we investigated the effects of a DNA methyltransferase (DNMT) inhibitor, 5-aza-2′deoxycytidine (5-aza-dC), on the methylation status of the RECK gene and tumor invasion in SACC cell lines. Methylation-specific PCR (MSP), Western blot analysis, and quantitative real-time PCR were used to investigate the methylation status of the RECK gene and expression of RECK mRNA and protein in SACC cell lines. The invasive ability of SACC cells was examined by the Transwell migration assay. Promoter methylation was only found in the ACC-M cell line. Treatment of ACC-M cells with 5-aza-dC partially reversed the hypermethylation status of the RECK gene and significantly enhanced the expression of mRNA and protein, and 5-aza-dC significantly suppressed ACC-M cell invasive ability. Our findings showed that 5-aza-dC inhibited cancer cell invasion through the reversal of RECK gene hypermethylation, which might be a promising chemotherapy approach in SACC treatment.

  11. Applied value of X-ray films for pediatric adenoidal hypertrophy (analysis of 86 cases)%数字化摄影诊断腺样体肥大的价值(附86例分析)

    Institute of Scientific and Technical Information of China (English)

    高明远; 刘晓敏

    2011-01-01

    Objective:To discuss the diagnostic value of nasopharyngeal lateral film for pediatric adenoid hypertrophy. Methods: 86 suspected cases with adenoid hypertrophy were subjected to nasopharyngeal lateral films. The thickness of adenoid and the widths of nasopharyngeal cavity were measured to calculate the adenoid-nasopharynx ratio (A/N). The degree of adenoid hypertrophy was assessed by the A/N and the pharyngeal airway space (PAS). Results:The ratios of A/N were found less than 0. 60 in 16 cases, 0. 61~0. 70 in 14 cases, and more than 0. 71 in 56 cases. The values of PAS were less than 5 mm in 36 cases. 6~10 mm in 24 cases, and more than 10 mm in 26 cases. Conclusion:Nasopharyngeal lateral film is a simple and correct examination for visualizing adenoid hypertrophy.%目的:探讨鼻咽部侧位片对小儿腺样体肥大的诊断价值.方法:86例怀疑腺样体肥大患儿均摄鼻咽部侧位片,测量腺样体厚度、鼻咽腔宽度及后气道宽度(PAS),并计算腺样体指数A/N,以评估腺样体肥大程度.结果:A/N≤0.60者16例,0.61~0.70者14例,A/N≥0.71者56例;PAS≤5mm者36例;6~10mm者24例;≥10mm者26例.结论:X线鼻咽侧位片是诊断腺样体肥大简单、经济的一种重要检查方法.

  12. 数字化X线摄影对儿童腺样体肥大的诊断价值分析%Application of Digital Radiography on Pediatric Adenoidal Hypertrophy

    Institute of Scientific and Technical Information of China (English)

    王琼

    2011-01-01

    Objective:To discuss the diagnostic value of nassopharyngeal lateral film for pediatric adenoid hypertrophy.Methods:43 ruspected cases with adenoid hypertrophy had nasopharyngeal lateral films taken.The thickness of adenoid,the widths of nasopharyngeal eavity were measured to calculated the adenoid-nasopharynx ratio (A/N).The degree of adenoid hypertrophy was assessed by the A/N and the pharngeal airway space(PAS)Results:The ratios of A/N were found less than 0.60 in 8 cases,0.61~0.70 in 7 cases and more than 0.71 in 28 cases.The values of PAS were less than 5mm in 18 cases,6~10mm in 12 cases and more than 10mm in 13 case.Conclusion:Nasopharyngeallateral film is a simple and correct examination for visualizing adenoid hypertrophy.%目的:探讨鼻咽部侧位片对小儿腺样体肥大的诊断价值.方法:43例怀疑腺样体肥大患几均摄鼻咽部侧位片,测量腺样体厚度、鼻咽腔宽度及后气道宽度(PAS),并计算腺样体指数A/N,以评估腺样体肥大程度.结果:A/N≤0.60者8例,0.61~0.70者7例,A/N≥0.71者28例;PAS≤5mm者18例;6~10mm者12例;≥10mm者13例.结论:X线鼻咽侧位片是诊断腺样体肥大简单、经济的一种重要检查方法.

  13. Cervical adenoid basal carcinoma:report of 15 cases%宫颈腺样基底细胞癌16例报告

    Institute of Scientific and Technical Information of China (English)

    郑建云; 方航荣; 孙斌斌; 刘冰

    2015-01-01

    目的:探讨宫颈腺样基底细胞癌(ABC)的临床、病理特点及鉴别诊断。方法:采用组织学及免疫组织化学方法对16例ABC进行观察、分析。结果:ABC临床症状不明显,妇科检查宫颈无明显异常或轻度糜烂;活检组织学检查常合并宫颈高级别鳞状上皮内瘤变(CIN3)或宫颈管黏膜原位腺癌(AIS)。行宫颈锥切或单纯子宫切除术。镜下:瘤细胞体积较小,形态一致,排列紧密,细胞质少,胞核深染,核分裂不活跃;呈小巢状、条索状在宫颈间质内浸润性生长,巢周围细胞呈栅栏状排列,部分细胞巢中央见腺腔样结构及鳞状分化,无明显间质反应。浸润深度2~7mm,宽度3~7mm。随访1~8年无异常发现。病理诊断:宫颈腺样基底细胞癌。结论:ABC常伴有CIN3和AIS,诊断应与腺样囊性癌(ACC)等宫颈肿瘤相鉴别。%Objective :To investigate the cervix adenoid basal carcinoma clinical ,pathological features and differential diagnosis .Methods :To observe and analyze 16 cases of adenoid basal carcinomar by tissue and immuno‐histochemistry methods and reviewd pertinent literatures .Results :The clinical symptoms of cervical adenoid basal carcinoma was not obvious ;Gynecological examination of cervical no abnormal or mild erosion ;Biops‐y :Often com‐panion with CIN3 or AIS .For conization of cervix or simple hysterectomy .Histological examination :Tumor cells with small volume ,Cell morphology consistent ,Closely packed ,Less cytoplasm ,With hyperchromatic nuclei ,Nu‐clear fission was not active .A small nests ,Cords and invasive growth in cervical stroma .Around the nest cells pali‐sading ,Part of the cell nests appeared adenoid structure and squamous differentiation .Stromal reaction was not ob‐vious .The depth of invasion 2~7mm ,3~7mm width .Follow up 1~8 years ,No abnormal findings .Pathologic di‐agnosis :Cervical adenoid basal carcinoma .Conclusion

  14. Clinical analysis of breast tubular adenoma and breast adenoid cystic carcinoma%乳腺管状腺瘤及腺样囊性癌临床分析

    Institute of Scientific and Technical Information of China (English)

    王云; 陈登庭

    2014-01-01

    Objective To investigate the incidence of the breast tubular glands lymphoma and the breast adenoid cystic carcinoma,and the correlation of breast tubular glands lymphoma with breast cancer.Methods A retrospective analysis was undertaken to analyze ten thousand pathologic medical records of inpatients and outpatients,and 86 breast tumors constituted by glandular epithelium cells and muscle epithelial cells were collected,which we reviewed again and compared with each other.Results Eighty-six breast tumors constituted by glandular epithelium cells and muscle epithelial cells include 79 breast tubular adenomas and 7 breast adenoid cystic carcinomas.Conclusions Morbidity of breast tubular adenoma which is used as a independent diagnosis trend to rise,and the breast tubular adenoma is proved to have malignant tendancy.The breast tubular adenoma probably is a precancerous lesion of the breast adenoid cystic carcinoma.%目的 探讨乳腺管状腺瘤(BTA)与乳腺腺样囊性癌(BACC)的发病情况,研究乳腺管状腺瘤与乳腺癌的关系.方法 回顾性分析10 000例住院患者及门诊患者病理资料,收集到86例腺上皮细胞和肌上皮细胞构成的乳腺肿瘤,并对该86例病理结果重新再审核、对比.结果 86例中乳腺管状腺瘤79例,乳腺腺样囊性癌7例.结论 乳腺管状腺瘤发病率呈上升趋势,已作为一种独立诊断,并有恶变倾向;乳腺管状腺瘤可能为腺样囊性癌的癌前病变.

  15. Aggressive Adenoid Cystic Carcinoma With Asymptomatic Spinal Cord Compression Revealed By A “Curtain Sign”

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    Martin Housset

    2008-08-01

    Full Text Available The author presents a case with an unusually aggressive evolution of an adenoid cystic carcinoma of the head and neck. The patient presented with sciatica one year after initial diagnosis. She was otherwise asymptomatic. Complete work-up for bone involvement, included bone scan and MRI. The patient had asymptomatic thoracic (T5 vertebral metastasis revealed by a typical curtain sign on MRI. She benefited from radiotherapy and did not develop respiratory distress, paraplegia or pain but died of other metastases.

  16. POLYSOMNOGRAPHY ANALYSES OF CHILDREN WITH ADENOID HYPERTROPHY%腺样体肥大病儿多导睡眠监测分析

    Institute of Scientific and Technical Information of China (English)

    杨美侠; 孙文海; 韩玉娥

    2012-01-01

    Objective To explore the variation of polysomnography (PSG) in children with adenoid hypertrophy. Methods Sixty-eight children underwent surgery for adenoid hypertrophy were selected in random, a retrospective analysis was done in respect of the relationship between lowest oxygen saturation (LSaO2), obstructive apnea index (OA1), apnea hypopnea index ( AH1) and body mass index (BMI) , size of the tonsil as well as age. Results It was found that LSaO2. AH1. OAI were not associated with different BMl in adenoid hypertrophy (P>0. 05). The differences of AHI between grade-1 and grade-2 and grade-3 hypertrophy of tonsils were significant CF=3. 777,P<0. 05). Conclusion In children with adenoid hypertrophy, the hypertrophy of tonsils has an important effect on AHI, but the effect of BMI is uncertain.%目的 探讨腺样体肥大病儿多导睡眠监测(PSG)的变化情况.方法 随机选取因腺样体肥大拟行手术治疗的病儿68例,回顾性分析腺样体肥大病儿最低血氧饱和度( LSaO2)、阻塞性呼吸暂停指数(OAI)、呼吸暂停低通气指数(AHI)与体质量指数(BMI)、扁桃体大小及年龄的关系.结果 BMI与LSaO2、AHI及OAI均无关(P>0.05).Ⅰ度与Ⅱ度、Ⅲ度扁桃体大组AHI比较差异有显著性(F=3.777,P<0.05).结论 腺样体肥大病儿中扁桃体肥大对AHI具有重要的影响,BMI对AHI无明确的影响.

  17. The choice of adenoid surgical indications and treatment observation%腺样体手术适应症的选择及治疗观察

    Institute of Scientific and Technical Information of China (English)

    赵春雷; 石青彦; 慕继霞

    2014-01-01

    Objective:To investigate the efficacy of surgical and conservative treatment in the moderate adenoid hypertrophy patients.Methods:120 cases of moderate adenoid hypertrophy patients treated with surgery (surgery group), and select other 120 cases of moderate adenoid hypertrophy patients with conservative treatment (conservative group), the two groups were compared for efficacy.Results:Surgery group cure rate of 97.5% of 120 patients, conservative group cure rate was 92.5%, showed no significant difference (p>0.05). Conclusion:Patients with moderate adenoid hypertrophy, conservative treatment as far as possible, if conservative treatment is not satisfactory then taken to surgery. Maximize using the less surgical trauma, less bleeding, low-temperature plasma ablation surgery under endoscope.%目的:探讨腺样体中度肥大患者手术和保守治疗的疗效。方法:选择腺样体中度肥大的患者120例进行手术治疗(手术组),同时选择120例腺样体中度肥大患者采用保守治疗(保守组),对两组病例进行疗效比较。结果:手术组120例治愈率97.5%,保守组治愈率92.5%,两组比较无明显差异(p>0.05)。结论:对于腺样体中度肥大患者,尽量采用保守治疗,如果保守治疗效果不理想再采取手术治疗,手术治疗尽量采用创伤小、出血少的鼻内镜下低温等离子消融手术。

  18. X线影像学检查诊断对儿童腺样体肥大的价值分析%Analysis of the Value of X-ray Imaging Diagnosis in Adenoid Hypertrophy of Children

    Institute of Scientific and Technical Information of China (English)

    华娟

    2015-01-01

    目的:分析X线影像学检查对诊断对儿童腺样体肥大的价值。方法该院2013年6月—2015年5月采取手术治疗的腺样体病理学肥大患儿共56例,均采用X-DR摄片机进行鼻咽部标准侧位片深吸气相投照,测量腺样体厚度、鼻咽腔宽度,计算腺样体厚度/鼻咽腔宽度比值(A/N),与术后实测A/N值比较两者相关性,观察X线影像诊断符合率。结果鼻咽部侧位片X线表现显示鼻咽顶部及后壁软组织增厚,向前下突起,边缘光滑,鼻咽腔隙变窄者28例,呈弥漫性向前下突起者17例,呈波浪状向前下突起者11例。术前后腺样体A/N值比较:术前X-DR检查A/N值为(0.81±0.16),术后术后实测腺样体厚度,计算A/N值为(0.80±0.15),P>0.05。术前X-DR诊断腺样体病理性肥大56例,均经手术证实为病理学腺样体增生,诊断符合率100%,未发现假阳性。结论X线影像学检查是了解腺样体大小的简便实用、安全有效的方法,诊断正确率高,对观察腺样体肥大有肯定的意义,是诊断儿童腺样体肥大影像检查的首选。%Objective To analyze the value of X-ray imaging in the diagnosis of adenoidal hypertrophy in children. Methods Dur-ing June 2013 to May 2015, in our hospital, Adenoid hypertrophy in children pathology surgical treatment of 56 cases, using X-DR radiography machine nasopharynx standard radiographs deep breathing congenial photo measuring the thickness of adenoids, nasal cavity width was calculated adenoid thickness/width ratio of the nasopharynx (A/N), and postoperative actual A/N value to compare the correlation observed X-ray image diagnosis rate. Results The nasopharyngeal lateral X-ray findings show the top of the posterior wall of the nasopharynx and soft tissue thickening, forward lower projection, smooth edge, narrowed nasopharyngeal cavities 28 cases, diffuse forward to the next projection 17 cases, wavy 11 cases under the forward projections. The preoperative adenoid A/N value

  19. Guidance of adenoid nasopharynx ratio in the treatment of pediatric adenoidal hypertrophy with secretory otitis media%A/N比值对治疗儿童腺样体肥大合并分泌性中耳炎的指导作用

    Institute of Scientific and Technical Information of China (English)

    陈俊; 何宁; 刘智勇; 梁红; 钟易; 彭琲

    2012-01-01

    Objective To explore the guidance role of the the adenoid A/N ratio in the treatment of adenoidal pathological hypertrophy with secretory otitis media (SOM). Methods 164 cases of SOM children before treatment were collected, whose A/N ratios were determinate on the lateral X-ray films of the nasopharynx ,when the A/N ratio was>0. 6 the adenoids pathological hypertrophy was diagnosed , in which 96 cases were showed moderate hypertrophy group (A/Nratio of 0. 61 - 0. 7) ,and 68 cases severe hypertrophy group (A/N ratio>0. 7) , The observation of drugs and surgical treatment effects in two groups were carried out in phases, Results The first phase of four weeks after drug treatment, the cure rate was 82. 3% in moderate hypertrophy group, 16. 2% in severe hypertrophy group(X2 = 31. 706, P0. 05) after four weeks treatment. Conclusion The A/N ratio is of significance in the treatment of adenoidal hypertrophy with secretory otitis . The surgical removal of adenoids should be combined the A/N ratio and the effect of drug treatment .%目的 探讨腺样体A/N比值对治疗腺样体病理性肥大合并分泌性中耳炎(SOM)的指导作用.方法 SOM患儿治疗前,根据鼻咽部侧位X线照片进行A/N比值测定,对A/N比值>0.6的腺样体病理性肥大164例,分为中度肥大组(A/N比值0.61~0.7)96例,重度肥大组(A/N比值>0.7)68例,对2组病例进行分阶段药物、手术治疗并观察治疗效果.结果 第一阶段经药物治疗4周后,中度肥大组治愈率82.3%,重度肥大组治愈率16.2%,检验结果为χ2=31.706,P0.05.结论 A/N比值对腺样体肥大合并SOM的治疗有指导作用,手术切除腺样体应结合A/N比值和药物治疗后的效果.

  20. Prevalence and associated survival of high-risk HPV-related adenoid cystic carcinoma of the salivary glands.

    Science.gov (United States)

    Qian, Xu; Kaufmann, Andreas M; Chen, Chao; Tzamalis, Georgios; Hofmann, Veit M; Keilholz, Ulrich; Hummel, Michael; Albers, Andreas E

    2016-08-01

    Adenoid cystic carcinoma (SACC) is a rare malignancy, but a frequent subtype in minor and major salivary glands. The molecular alterations or biomarkers that underlie its development and progression as well as therapy outcomes are poorly characterized. The main study goal was to investigate reliable biomarkers and patient-related factors that may have impact on recurrence and long-term survival of SACC. The prevalence of human papilloma virus (HPV) in SACC was determined by HPV-DNA genotyping and p16 immunostaining. Epithelial growth factor receptor (EGFR), p53 and Ki-67 expression were also evaluated. Twenty-eight (42%) of 67 patients were HPV-DNA positive. Kaplan-Meier analysis indicated that SACC patients with metastases (P=0.03) had a poor overall survival (OS) and a shorter recurrence-free survival (P<0.001). Positive resection margins significantly predicted shorter recurrence-free survival (P=0.01). In the multivariate analysis, non-metastatic disease (P=0.033) and p16 positivity (P=0.005) have shown their prediction value for OS while non-metastatic disease (P=0.002), HPV positivity (P=0.041) and negative resection margin predicted a better recurrence-free survival. The present study documents for the first time the positivity for HPV infection and overexpression of certain markers (p16, Ki-67, EGFR and p53) used in diagnostics in SACC as well as characterizes clinical entities. These factors might be exploited in the future as biomarkers for its prognostic value. Using the clinical and pathological basis for predicting different outcomes could significantly facilitate SACC stratification and potentially directing treatment.

  1. Primary adenoid cystic carcinoma of the tracheobronchial tree: A decade-long experience at a health centre in Mexico

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    Arturo Cortés-Télles

    2012-01-01

    Full Text Available Background : Mexico′s National Institute of Respiratory Diseases (NIRD is a third-level national reference center. Primary adenoid cystic carcinoma (PACC is an uncommon neoplastic disorder; hence improvements in the description of this disease are needed. Materials and Methods: This is a retrospective clinical study based on all consecutive patients with pathological diagnoses of PACC seen at the NIRD between January 1, 2000 and December 31, 2009. Results: We identified 9 cases of PACC (67% female out of a total of 2,634 patients with lung cancer seen during the period analyzed. The mean age of those 9 patients was 41 years (IQR 36-57, and the frequency of PACC at our center was 0.3%. It is important to note that 67% of those patients had a history of smoking and that 6 of the 9 had the antecedent of previous exposure to biomass fuel smoke. Baseline arterial blood gas analyses revealed a median of 61 mmHg for pO 2 and 28.5 mmHg for pCO 2 . Median FVC was 78%, while FEV 1 was 77% with an FEV 1 /FVC ratio of 78. Death occurred in 56% of cases, and the median survival time was 17 months (IQR 6-26 after the initial diagnosis. Conclusions: The frequency of tracheobronchial PACC among patients with lung cancer was similar to that previously reported (0.3%. According to our results, lung function has no specific phenotype in this disease; however, some abnormalities could be related to potential risk factors such as tobacco use and exposure to biomass fuel smoke.

  2. Inhibition of mTOR reduce Stat3 and PAI related angiogenesis in salivary gland adenoid cystic carcinoma.

    Science.gov (United States)

    Yu, Guang-Tao; Bu, Lin-Lin; Zhao, Yu-Yue; Liu, Bing; Zhang, Wen-Feng; Zhao, Yi-Fang; Zhang, Lu; Sun, Zhi-Jun

    2014-01-01

    Angiogenesis is a complex biological process, which is involved in tumorigenesis and progression. However, the molecular mechanism of underlying angiogenesis remains largely unknown. In this study, we accessed the expression of proteins related angiogenesis by immunohistochemical staining of human tissue microarray which contains 72 adenoid cystic carcinoma (AdCC), 12 pleomorphic adenoma (PMA) and 18 normal salivary gland (NSG) using digital pathological scanner and scoring system. We found that the expression of p-S6(S235/236) (a downstream molecule of mTOR), p-Stat3(T705), PAI, EGFR, and HIF-1α was significantly increased in AdCC as compared with PMA and (or) NSG (p 0.05). Correlation analysis of these proteins revealed that p-S6(S235/236) up-regulates the expression of EGFR/p-Stat3(T705) (p PAI (p PAI associated with angiogenesis (CD34) and proliferation (Ki-67). In vitro, Rapamycin suppressed the expression of p-S6(S235/236), EGFR, p-Stat3(T705), HIF-1α and PAI. Further more, target inhibition of mTOR by rapamycin effectively reduced tumor growth of SACC-83 cells line nude mice xenograft and decreased the expression of p-S6(S235/236), EGFR/p-Stat3(T705) and HIF-1α/PAI. Taken together, these data revealed that mTOR signaling pathway regulates tumor angiogenesis by EGFR/p-Stat3(T705) and HIF-1α/PAI. Inhibition of mTOR by rapamycin could effectively reduced tumor growth. It is likely that mTOR inhibitors may be a potential candidate for treatment of AdCC.

  3. Myoepithelial differentiation in cribriform, tubular and solid pattern of adenoid cystic carcinoma: A potential involvement in histological grading and prognosis.

    Science.gov (United States)

    Du, Fei; Zhou, Chuan-Xiang; Gao, Yan

    2016-06-01

    Adenoid cystic carcinoma (AdCC) is known as a biphasic tumor composed of ductal and myoepithelial cells. The present study aimed to evaluate the amount and distribution of the myoepithelial cells in cribriform, tubular and solid subtypes of AdCC and analyze their relationship with histological grading and prognosis. A panel of myoepithelial markers including CK5/6, p63, p40, D2-40, calponin, α-SMA, S-100, and vimentin, together with a luminal cell marker CK7, and Ki-67 were used for immunohistochemical study in 109 AdCCs that included 38 cribriform, 36 tubular and 35 solid subtypes. The myoepithelial cells were labeled and found lined cystic-like paces, located at the periphery of the cribriform arrangements, and presented at the nonluminal cells of the two-layered tubular structures, while absent or dispersed in the solid pattern. Meantime, the solid subtype presented a higher proliferation rate assessed by mitotic count and Ki-67 labeling index, followed by poorer overall survival and recurrent-free survival. Furthermore, CK7 expression was found higher in solid pattern than in cribriform-tubular subtype, which showed negative correlation with the myoepithelial markers including D2-40, Calponin, α-SMA, p63, p40 and vimentin. The solid pattern of AdCC showed gland differentiation but loss of myoepithelial differentiation with a higher proliferation and more aggressiveness as well as poorer prognosis compared with the cribriform-tubular subtypes, which implies that loss of MEC differentiation might contribute to the poor prognosis of the solid subtype of AdCC. However, further studies are required to clarify its exact role in AdCC progression.

  4. Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma.

    Science.gov (United States)

    Persson, Marta; Andrén, Ywonne; Moskaluk, Christopher A; Frierson, Henry F; Cooke, Susanna L; Futreal, Philip Andrew; Kling, Teresia; Nelander, Sven; Nordkvist, Anders; Persson, Fredrik; Stenman, Göran

    2012-08-01

    Adenoid cystic carcinoma (ACC) of the head and neck is a malignant tumor with poor long-term prognosis. Besides the recently identified MYB-NFIB fusion oncogene generated by a t(6;9) translocation, little is known about other genetic alterations in ACC. Using high-resolution, array-based comparative genomic hybridization, and massively paired-end sequencing, we explored genomic alterations in 40 frozen ACCs. Eighty-six percent of the tumors expressed MYB-NFIB fusion transcripts and 97% overexpressed MYB mRNA, indicating that MYB activation is a hallmark of ACC. Thirty-five recurrent copy number alterations (CNAs) were detected, including losses involving 12q, 6q, 9p, 11q, 14q, 1p, and 5q and gains involving 1q, 9p, and 22q. Grade III tumors had on average a significantly higher number of CNAs/tumor compared to Grade I and II tumors (P = 0.007). Losses of 1p, 6q, and 15q were associated with high-grade tumors, whereas losses of 14q were exclusively seen in Grade I tumors. The t(6;9) rearrangements were associated with a complex pattern of breakpoints, deletions, insertions, inversions, and for 9p also gains. Analyses of fusion-negative ACCs using high-resolution arrays and massively paired-end sequencing revealed that MYB may also be deregulated by other mechanisms in addition to gene fusion. Our studies also identified several down-regulated candidate tumor suppressor genes (CTNNBIP1, CASP9, PRDM2, and SFN) in 1p36.33-p35.3 that may be of clinical significance in high-grade tumors. Further, studies of these and other potential target genes may lead to the identification of novel driver genes in ACC.

  5. Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands.

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    Nadia Zaib

    2014-02-01

    Full Text Available To study the immunohistochemical pattern of CD 117, glial fibrillary acidic protein (GFAP, smooth muscle actin (SMA and CD 43 in pleomorphic adenoma (PA, adenoid cystic carcinoma (AdCC and polymorphous low grade adenocarcinoma (PLGA of minor salivary glands.Twenty cases of PA, 20 cases of AdCC and 10 cases of PLGA were retrieved from record files along with their paraffin blocks at Armed Forces Institute of Pathology, Pakistan. New histological diagnosis was made on freshly prepared H&E sections followed by application and analysis of immunostains.The mean age of the patients was 44 ± 15 (mean SD (range; 17-86 years. There were 26 male and 24 female patients with a male to female ratio of 1.08:1. Fourteen cases of PA, 14 cases of AdCC and 6 cases of PLGA were positive for CD117. In case of GFAP, only 9 cases of AdCC and 3 cases of PLGA were positive; however, 16 cases of PA were also positive. Twelve cases of AdCC and 7 cases of PA were positive for SMA and half of the PLGA cases were also reactive. Nonetheless, the least expression was seen in case of CD 43, where only five cases of AdCC were positive. Six cases of PA and three cases of PLGA were also positive.Our results suggest that the use of GFAP, SMA, CD 117 and CD 43 as an adjunct to histological examination is not helpful in differentiating PA, AdCC and PLGA from one another.

  6. Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma.

    Directory of Open Access Journals (Sweden)

    Jun Jia

    Full Text Available Human adenoid cystic carcinoma (ACC is characterized by diffused invasion of the tumor into adjacent organs and early distant metastasis. Anoikis resistance and epithelial mesenchymal transition (EMT are considered prerequisites for cancer cells to metastasize. Exploring the relationship between these processes and their underlying mechanism of action is a promising way to better understand ACC tumors. We initially established anoikis-resistant sublines of ACC cells; the variant cells revealed a mesenchymal phenotype through Slug-mediated EMT-like transformation and displayed enhanced metastatic potential both in vitro and in vivo. Suppression of EMT by knockdown of Slug significantly impaired anoikis resistance, migration, and invasion of the variant cells. With overexpression of Slug and Twist, we determined that induction of EMT in normal ACC cells could prevent anoikis, albeit partially. These findings strongly suggest that EMT is indispensable in anoikis resistance, at least in ACC cells. Furthermore, we found that the EGFR/PI3K/Akt pathway acts as the common regulator for EMT-like transformation and anoikis resistance, as confirmed by their specific inhibitors. Gefitinib and LY294003 restored the sensibilities of anoikis-resistant cells to anoikis and simultaneously impaired their metastatic potential. In addition, the results from our in vivo model of metastasis suggest that pretreatment with gefitinib promotes mouse survival by alleviating pulmonary metastasis. Most importantly, immunohistochemistry of human ACC specimens showed a correlation between the overexpression of Slug and EGFR staining. This study has demonstrated that Slug-mediated EMT-like transformation is required by human ACC cells to achieve anoikis resistance and their metastatic potential. Targeting the EGFR/PI3K/Akt pathway holds potential as a preventive strategy against distant metastasis of ACC.

  7. Biological therapy of salivary adenoid cystic carcinoma%生物治疗涎腺腺样囊性癌的研究进展

    Institute of Scientific and Technical Information of China (English)

    李敏敏; 徐明菊; 孙万邦

    2014-01-01

    Adenoid cystic carcinoma is one of the most common malignant tumors of the salivary gland.Two biological characteristics of the tumors with significant:high perineural-invasion and metastatic lung.These two biological characteristics have a direct impact on the treatment and prognosis of adenoid cystic carcinoma.Surgical therapy,radiotherapy and chemotherapy effect of the tumor are not very satisfactory.Therefore,The tumor biological characteristics and study on biologic therapy has attracted wide attention from scholars at home and abroad,and has made some achievements.Now make a review of the progress of biological therapy in recent years,.%涎腺腺样囊性癌是目前最为常见的涎腺恶性肿瘤之一,该肿瘤具有显著的两大生物学特性:嗜神经侵袭性和肺高转移性,而这两大生物学特性也直接影响着涎腺腺样囊性癌的治疗和预后.该肿瘤对手术、放射治疗及化学药物治疗效果均不十分理想,因此,生物治疗引起了国内外学者的广泛关注研究,并取得了一定的成果.

  8. Interdisciplinary treatment of the patient with adenoid cystic carcinoma of the Bartholin’s gland resulting in 15 years’ survival: a case report and review of literature

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    Marek Nowak

    2014-11-01

    Full Text Available Carcinoma of the Bartholin’s gland is very rare, comprises below 2% of Bartholin’s gland lesions and adenoid cystic carcinoma (ADC is one of the most uncommon variants and accounts for 10-15% of Bartholin’s gland malignancies. There is no consensus on treatment of ADC of the Bartholin’s gland: reported cases were treated with local excision or vulvectomy with or without lymphadenectomy followed or not by radiotherapy. The survival of patients varies significantly, so we present a case of interdisciplinary treatment of ADC resulting in 15 years’ survival. The patient was initially treated with local excision, but the margins were not clear. Then vulvectomy, inguinal lymphadenectomy and adjuvant brachytherapy were performed resulting in 7 years free of the disease. Relapses were excised by abdominoperineal amputation of the rectum and distal part of the vagina with sigmoideostomy, excisions of local recurrences in vagina and metastasectomy of isolated lung metastases. The patient died manifesting multiple lung metastases 15 years after the initial diagnosis. Based on our experience and world literature, in cases of adenoid cystic carcinoma of the Bartholin’s gland, vulvectomy with or without lymphadenectomy should be considered as a treatment of choice and in patients with positive margin, surgery should be extended by adjuvant radiotherapy.

  9. Interdisciplinary treatment of the patient with adenoid cystic carcinoma of the Bartholin's gland resulting in 15 years' survival: a case report and review of literature.

    Science.gov (United States)

    Nowak, Marek; Rycel, Magdalena; Szpakowski, Marian; Kulig, Andrzej; Sobotkowski, Janusz; Dziki, Adam

    2014-10-01

    Carcinoma of the Bartholin's gland is very rare, comprises below 2% of Bartholin's gland lesions and adenoid cystic carcinoma (ADC) is one of the most uncommon variants and accounts for 10-15% of Bartholin's gland malignancies. There is no consensus on treatment of ADC of the Bartholin's gland: reported cases were treated with local excision or vulvectomy with or without lymphadenectomy followed or not by radiotherapy. The survival of patients varies significantly, so we present a case of interdisciplinary treatment of ADC resulting in 15 years' survival. The patient was initially treated with local excision, but the margins were not clear. Then vulvectomy, inguinal lymphadenectomy and adjuvant brachytherapy were performed resulting in 7 years free of the disease. Relapses were excised by abdominoperineal amputation of the rectum and distal part of the vagina with sigmoideostomy, excisions of local recurrences in vagina and metastasectomy of isolated lung metastases. The patient died manifesting multiple lung metastases 15 years after the initial diagnosis. Based on our experience and world literature, in cases of adenoid cystic carcinoma of the Bartholin's gland, vulvectomy with or without lymphadenectomy should be considered as a treatment of choice and in patients with positive margin, surgery should be extended by adjuvant radiotherapy.

  10. Carcinoma adenóide cístico de conduto auditivo externo Adenoid cystic carcinoma of the external auditory canal

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    Carolina Pimenta Carvalho

    2008-10-01

    Full Text Available O carcinoma adenóide cístico é um raro tumor originado das glândulas salivares, principalmente quando se localiza no conduto auditivo externo. Apresenta alta taxa de invasão perineural e metástases, devendo ser tratado com combinação de cirurgia agressiva seguida de radioterapia. Relatamos um caso de carcinoma adenóide cístico de conduto auditivo externo em paciente de 77 anos com queixa de hipoacusia e otalgia. A mesma foi tratada com mastoidectomia radical e radioterapia.Adenoid cystic carcinoma is a rare tumor originating from the salivary glands, especially when arise the external auditory canal. This tumor has high rate of perineural invasion and metastasis, then must be treated with aggressive surgery combined with postoperative radiation. We report a case of an adenoid cystic carcinoma arising the external auditory canal of 77 years old female patient, who complained hypoacusis and pain. She was treated by radical mastoidectomy and radiotherapy.

  11. Treatment of Adenoid Hypertrophy: A Prospective Randomized Control Clinical Trial%腺样体肥大治疗的前瞻性随机对照研究

    Institute of Scientific and Technical Information of China (English)

    匡嘉丽; 李健; 陆洋; 易索芬; 张平

    2012-01-01

    [Objective] To compare the effects of phannacotherapy and surgical intervention in the treatment of adenoid hypertrophy and to make evidence base for standard pharmacotherapy. [Methods] 83 outpatient children cases with adenoid hypertrophy were randomly divided into two groups (case history >12 weeks) pure pharmacotherapy group (PP group) and surgical intervention group (SP group). Clinical therapeutic effect evaluation was did on 3 months after treatment (pharmacotherapy or surgery + phannacotherapy) including adenoid size, immunoglobulin levels, effect evaluation of secretory otitis media, children rhinosinusitis and children obstructive sleep apnea and hyponea syndrom. Single sample J-test/two groups of independent sample t test and KruskalWallis Test of orderly classified data were used to compare the clinical therapeutic effect of two groups. [ Results ] There was no statistical difference of adenoid size between the two groups before treatment, but there was statistical difference of adenoid size on 3 months after treatment between two groups(P=0.038). Adenoid size after treatment was statistically different with it before treatment in each group (P=0.000). IgA, IgG, and IgM levels before treatment were no statistically different with its after treatment of 3 months in each group (P>0.05). There were no statistic differences between two groups when effects of secretory otitis media, children rhinosinusitis, and children obstructive sleep apnea and hyponea syndrom were evaluated by Kruskal Wallis test (P=0.822, 0.773, 0.559). [Conclusions] Pure standard pharmacotherapy could achieve good results. Effects evaluation after 3 months of treatment showed that surgical intervention did not increase therapeutic effect on adenoid hypertrophy. Children patients suffering from adenoid hypertrophy should be treated firstly by pharcotherapy, and surgical intervention should be more cautious and strict.%[目的]采用随机对照方法研究药物治疗及手术干预在

  12. 儿童腺样体肥大3种切除方式疗效分析%Retrospective Analysis on Three operative method for Curettage of Adenoids in Children

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    杜英; 孔巧; 郭筠芳

    2009-01-01

    目的:比较传统经口腔腺样体刮除术、鼻内镜下经鼻腔腺样体切除术及鼻内镜下经口鼻腔双径路腺样体切除术的疗效.方法:回顾性分析202例接受腺样体肥大手术患儿的临床资料,比较3种术式术后患儿夜间打鼾、鼻塞、鼻漏及听力等症状的恢复和腺样体残留等情况.结果:传统经口腔腺样体刮除术后6例患儿存在腺样体残留,其他2种术式术后无腺样体残留.鼻内镜下经口鼻腔双径路腺样体切除术后患儿打鼾、鼻塞症状改善明显.结论:腺样体肥大的理想手术方法为鼻内镜下经口鼻腔双径路腺样体切除术.%Objective:To compare the three different approaches in the curettage of adenoid hypertrophy, the traditional curettage of adenoids through mouth (group A), the adenoidectomy through nose under nasal endoscope (group B) ,the adenoidectomy through both mouth and nose under nasal endoscope (group C). Method:Clinical data of adenoid hypertrophy patients who had accepted the surgery therapy, were retrospectively analyzed;Symptoms of night snore, nasal obstruction, rhinorrhea, acouesthesia and the adenoid residue among the patients who had got three different surgerys.were compared among them. Result: Adenoid residue were found in six cases of group A. No adenoid residue were found in group B and C . Recovery of nasal obstruction and night snore in group C were much better than that in group A and B(P<0. 01,<0. 05). Conclusion:The ideal way to cure adenoidal hypertrophy is the adenoidectomy done through mouth and nose under nasal endoscope.

  13. Growth of the nasopharynx and adenoidal development in Brazilian subjects Crescimento da nasofaringe e desenvolvimento da adenóide em brasileiros

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    Beatriz de Souza Vilella

    2006-03-01

    Full Text Available The purpose of this research was to study the growth of the nasopharynx and adenoid development. Lateral cephalometric radiographs obtained from 320 white Brazilian subjects between 4 and 16 years of age were used. All the participants were nose breathers and none of them had previously undergone adenoidectomy. Tracings were made from the radiographs and cephalometric measurements were performed. The results showed that adenoid sagital thickness is larger in the age group 4 - 5 years and decreases progressively. There is a slight increase in the age group 10 - 11 years, but afterwards the decrease continues. However, the nasopharyngeal free airway space does not decrease in the age group 10 - 11 years, despite the increasing thickness of the adenoid. This is attributable to the downward displacement of the hard palate, resulting in an increase of the free airway space due to growth. Although the nasopharynx follows a growth pattern similar to that of the rest of the body, adenoid tissue does not. Adenoidal development seems to differ from that of other lymphatic tissues, showing a peculiar pattern that can be revealed when hypertrophy due to infections and allergies is eliminated.O objetivo da pesquisa foi estudar o crescimento da nasofaringe e o desenvolvimento da adenóide. Foram utilizadas as radiografias cefalométricas de perfil obtidas de 320 indivíduos brasileiros brancos, cujas idades variavam entre 4 e 16 anos. Todos os participantes apresentavam respiração predominantemente nasal e não haviam sido submetidos previamente à adenoidectomia. A partir das radiografias foram feitos traçados cefalométricos, sobre os quais foram realizadas medições. Os resultados revelaram que a espessura sagital da adenóide é maior na faixa etária de 4 a 5 anos, regredindo, então, progressivamente, até a faixa etária de 10 a 11 anos, quando ocorre um leve aumento, voltando a diminuir em seguida. O espaço aéreo livre nasofaríngeo, entretanto

  14. Clinical assessment on adenoidal hypertrophy induced nasal ventilation function%儿童腺样体肥大所致鼻通气功能临床评估

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    邓启华

    2015-01-01

    目的:评估儿童腺样体肥大患者的鼻通气功能,为手术治疗提供科学依据。方法选取55例儿童腺样体肥大患者,分别在手术前和手术后进行症状记分表调查以及鼻声反射测量,并与45例健康儿童的各项指标进行对照研究。结果与手术前比较,观察组患者在手术后鼻阻塞症状记分降低,差异有统计学意义(P<0.01);与手术前比较,观察组患者手术后的两侧鼻腔总的鼻气道阻力(NAR)明显降低(t=2.1280,P<0.05),双侧鼻咽腔容积(NPV)明显增加(t=13.1806,P<0.01);与对照组比较,手术前的 NAR、NPV和双侧鼻腔最小横截面积(MC‐SA)差异均有统计学意义(t=5.9824,P<0.01;t=6.5273,P<0.01;t=4.1174,P<0.01),手术6周后的NAR、NPV和MCSA差异均有统计学意义(t=4.0328,P<0.01;t=7.4901,P<0.01;t=3.1495,P<0.01)。结论腺样体手术可明显改善儿童鼻通气状态,且鼻声反射测量可以作为腺样体肥大所致儿童鼻通气功能的定量评估工具。%Objective To assess the nasal ventilation function in the patients with adenoidal hypertrophy to provide a scientific basis for the surgical treatment .Methods 55 children cases of adenoidal hypertrophy were select‐ed .The symptom score tables were surveyed and the acoustic rhinometry measurements were performed before and after surgery .The results were conducted the control research with those in 45 normal children .Results Compared with before treatment ,the nasal obstruction symptom score after treatment in the observation group was significantly decreased ,the difference was statistically significant (P< 0 .01);compared with before operation ,NAR after opera‐tion in the observation group was decreased significantly (t=2 .128 0 ,P<0 .05) ,while NPV was increased signifi‐cantly (t=13 .180 6 ,P< 0 .01);compared with control group ,the

  15. 数字化鼻咽侧位影像在儿童腺样体肥大的诊断中的价值%Value of Direct Digital Radiography Imaging in the Preoperative Diagnosis of Children with Adenoid Hypertrophy

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    潘鄂武; 陈军; 罗志宏; 彭宙锋; 汪炜伟; 刘昌盛

    2011-01-01

    目的:探讨直接数字化X线摄影(DR)鼻咽侧位片在儿童腺样体肥大的诊断中的价值.方法:采用鼻咽侧位片腺样体-鼻咽腔(A/N)比率测量值,结合临床症状及纤维鼻咽镜检查儿童腺样体的分度范围(Ⅰ-Ⅳ°)进行影像诊断.结果:112例A/N在0.61-0.89之间的患儿,经保守治疗无效,再经低温等离子射频切割消融术治疗后痊愈出院.结论:鼻咽侧位A/N比值,可作诊断儿童腺样体肥大的客观指标.%Objective; To discuss the value of the lateral direct digital radiography (DR) imaging of nasopharynx in the diagnosis of children with adenoid hypertrophy. Methods: Nasopharynx lateral DR was used to measure the ratio of adenoid to nasopharynx cavity (A/N). Imaging diagnosis was made upon the basis of combining the clinical symptoms and the nasopharyngo-fiberoscope to classify the children's adenoids (grades I ~IV°). Results; A total of 114 cases of adenoid hypertrophy with the ratio of A/N ranging from 0. 61 to 0. 89 were treated by low-temperature plasma radiofrequency ablation after the conventional treatment was not effective. Conclusion: The ratio of A/N might be an objective index in the diagnosis of children's adenoid hypertrophy.

  16. The Prevalence of Secretory Otitis Media and Influencing Factors in Children with Adenoidal Hypertrophy%腺样体肥大儿童分泌性中耳炎发生率及其影响因素分析

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    王淑芬; 王智楠; 徐忠强

    2012-01-01

    Objective To study the prevalence of secretory otitis media and its influencing factors in children with adenoidal hypertrophy. Methods Date of nasopharyngofibcroscopy or nasal endoscopy of the nasopharynx and acoustic immitancc were collected from 6256 cases of pediatric adenoidal hypertrophy admitted for surgical treatment. The pure tone audiomctry or ABR were obtained in children of secretory otitis mcdia(SOM). The prevalence ofsecretory otitis media was analyzed in children with adenoidal hypertrophy according to different ages,degrees of adenoidal hypertrophy and course of diseases. Results The results of acoustic immitancc data showed that secretory o-titis media was confirmed in 2 702 cases (43. 19% ,2 702/6 256) , although only 654 cascsClO. 45% ,654/6 256) had audiologic complaints. Peak incidence of otitis mcdia(69. 76% ,1 119/1 604) was at age of 3~5 years old along, with the increase of age,the prevalence of SOM was decreased. The prevalence of SOM with HI" adenoidal hypertrophy was 61. 73% (1 639/2 655) and much higher than those of I "(21.11% , 163/772) , fj "(31. 81 % , 900/2 829) (P0.05).结论 本组腺样体肥大患儿SOM发生率为43.19%,低龄和腺样体肥大程度是腺样体肥大患儿并发SOM的影响因素,而病程对其无明显影响.

  17. Expression of CysLTR-1 and CysLTR-2 in adenoid tissues from children with adenoid hypertrophy%CysLTR-1和CysLTR-2在腺样体肥大儿童腺样体组织中的表达

    Institute of Scientific and Technical Information of China (English)

    朱美华; 梁敏; 王志坚; 沈雁; 温红艳; 翟锦明; 杨晓彬

    2015-01-01

    Objective To examine the expression of cysteinyl leukotriene receptor-1 (CysLTR-1) and cysteinyl leukotriene receptor-2 (CysLTR-2) in the adenoid tissues from children with adenoid hypertrophy (AH) and to explore the role of leukotrienes in the pathogenesis of AH. Methods Sixty children with AH who were treated by adenoidectomy and/or tonsillectomy were classified into two groups: simple AH and AH plus allergic rhinitis (n=30 each). Twenty children who underwent tonsillectomy due to recurrent purulent tonsillitis were selected as the control group. The expression of CysLTR-1 and CysLTR-2 in the excised tonsil and/or adenoid tissues was determined by immunolfuorescence histochemical labeling and integrated optical density measurement. Results The expression of CysLTR-1 and CysLTR-2 in the adenoid and tonsil tissues increased signiifcantly in both the simple AH group and AH plus allergic rhinitis group compared with the control group (P<0.01). The expression of CysLTR-1 and CysLTR-2 in the AH plus allergic rhinitis group increased more signiifcantly compared with the simple AH group (P<0.01). Conclusions CysLTR-1 and CysLTR-2 are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH.%目的:检测腺样体肥大(adenoid hypertrophy, AH)患儿腺样体组织中半胱氨酸白三烯受体1(CysLTR-1)和半胱氨酸白三烯受体2(CysLTR-2)的表达,探讨白三烯在AH发病中的作用。方法将60例行腺样体/扁桃体切除的AH患儿分为单纯AH组与伴变态反应性鼻炎AH组(每组30例),以反复化脓性扁桃体炎行扁桃体切除的20例患儿作为对照组。通过免疫荧光组织化学标记法及累积光密度(IOD)测量方法观察各组患儿术后扁桃体/腺样体组织中CysLTR-1和CysLTR-2的表达。结果在两个AH组的腺样体组织和扁桃体组织中,CysLTR-1和CysLTR-2的表达强度均明显高于对照组(P

  18. Combined Power System and Adenoid Suction Cutting Operation in the Treatment of 96 Cases of Adenoidal Hypertrophy%鼻口联合动力系统腺样体吸割术治疗腺样体肥大96例

    Institute of Scientific and Technical Information of China (English)

    曾刚

    2013-01-01

    Objective:To study the endoscopic and combined power system of adenoidectomy in the treatment of adenoid hypertrophy and clinical application value.Methods:192patients with adenoidal hypertrophy were randomly divided into the observation group and the control group with 96 cases in each group, the observation group was treated with nasal endoscopic combined power system and adenoidectomy, the control group using conventional curettage of adenoids. Results:the total effective rate in the observation group and 93.75%in control group, the total efficiency of 81.25%(P<0.01), during the follow-up period, there were no complications were observed, while in the control group 10 cases with adenoid tissue residue (P<0.01).Conclusion:nasal endoscopic and combined power system adenoidectomy avoids the blindness of operation, clear surgical field, was resected completely,reduce the occurrence of postoperative complications.%  目的:探讨鼻内窥镜下鼻口联合动力系统腺样体切除术在腺样体肥大治疗中的临床应用价值。方法:将192例腺样体肥大患者随机分为观察组和对照组各96例,观察组采用鼻内窥镜下鼻口联合动力系统腺样体切除术,对照组采用常规腺样体刮除术。结果:观察组总有效率93.75%,对照组总有效率81.25%(P<0.01),随访期间,观察组未见并发症发生病例,对照组有10例患者出现腺样体组织残留(P<0.01)。结论:鼻内窥镜下鼻口联合动力系统腺样体切除术避免了常规操作的盲目性,术野清晰、切除完全、减少了术后并发症的发生。

  19. Inhibitory effects of silibinin on proliferation and lung metastasis of human high metastasis cell line of salivary gland adenoid cystic carcinoma via autophagy induction

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    Jiang C

    2016-10-01

    Full Text Available Canhua Jiang,1 Shufang Jin,1 Zhisheng Jiang,1 Jie Wang2 1Department of Oral and Maxillofacial Surgery, Xiangya Hospital, 2Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China Objective: To investigate the possible mechanisms and effects of silibinin (SIL on the proliferation and lung metastasis of human lung high metastasis cell line of salivary gland adenoid cystic carcinoma (ACC-M.Methods: A methyl thiazolyl tetrazolium assay was performed to detect the inhibitory effects of SIL on the proliferation of ACC-M cells in vitro. Fluorescence microscopy and transmission electron microscopy were used to observe the autophagic process. Western blot was performed to detect the expression of microtube-related protein 1 light-chain 3 (LC3. An experimental adenoid cystic carcinoma (ACC lung metastasis model was established in nude mice to detect the impacts of SIL on lung weight and lung cancer nodules. Immunohistochemistry was used to detect the expressions of LC3 in human ACC samples and normal salivary gland tissue samples.Results: SIL inhibited the proliferation of ACC-M cells in a dose- and time-dependent manner, and inductively increased the autophagic bodies in ACC-M cells. Furthermore, SIL could increase the expression of LC3 in ACC-M cells and promote the conversion of LC3-I into LC3-II in a dose- and time-dependent manner. In the ACC lung metastasis model, the lung weight and left and right lung nodules in the SIL-treated group were significantly less than those in the control group (P<0.05. The expressions of LC3-I and LC3-II as well as the positive expression rate of LC3 (80% significantly increased, but the positive expression of LC3 in human ACC (42.22% reduced significantly.Conclusion: SIL could inhibit the proliferation and lung metastasis of ACC-M cells by possibly inducing tumor cells autophagy. Keywords: silibinin, adenoid cystic carcinoma, ACC-M cells, autophagy

  20. Effect of steroid nasal spray on pediatric allergic rhinitis in children with adenoidal hypertrophy%鼻用类固醇治疗儿童变应性鼻炎伴腺样体肥大疗效分析

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    韦一; 王德乐; 王韶鉴; 曾莉

    2015-01-01

    Objective To evaluate the curative effect of steroid nasal spray on pediatric allergic rhinitis with adenoidal hypertrophy.Methods A total of 261 children with adenoids served as the control group,of them,190 children (72.7%)were with adenoid hypertrophy.A total of 162 children with allergic rhinitis and adenoids served as the ex-perimental group,of them,110 children(67.2%)were with adenoid hypertrophy.The two groups were both treated by Fluticasone propionate nasal spray (50 μg per nostril a day)for 3 months.Results Adenoidal hypertrophy incidence was 72.7% in the control group and 67.2% in the experimental group (χ2 =1.16,P >0.05).112 (58.9%)patients in the control group and 89 (80.9%)patients in the experimental group had the adenoidal volume decreased (χ2 =19.04,P <0.01).Conclusion After steroid nasal spray treatment,the adenoidal volume is much more decreased in the experimental group than in the experimental group.Steroid nasal spray is the first choice for children with allergic rhinitis and adenoidal hypertrophy.%目的:探讨儿童变应性鼻炎(AR)与腺样体肥大的关系,评价鼻用类固醇治疗儿童变应性鼻炎伴腺样体肥大的疗效。方法对照组为单纯腺样体生长儿童261例,其中腺样体肥大190例(72.7%)。观察组为变应性鼻炎伴腺样体生长儿童162例,其中腺样体肥大110例(67.2%)。两组均给予鼻用类固醇(丙酸氟替卡松喷剂)持续喷鼻3个月后于鼻内镜下复查。结果对照组并发腺样体肥大构成比为72.7%,观察组并发腺样体肥大构成比为67.2%,差异无统计学意义(χ2=1.16,P >0.05)。对照组采用鼻用类固醇治疗后有效腺样体体积减少112例(58.9%),观察组有效腺样体体积减小89例(80.9%)(χ2=19.04,P <0.01)。结论经鼻用类固醇治疗,变应性鼻炎伴腺样体肥大患儿腺样体体积减小程度较单纯腺样体肥大患儿明显。对

  1. Clinical Analysis of the Treatment of Adenoid Hypertrophy in Children with Semiconductor Laser%半导体激光经鼻治疗小儿腺样体肥大疗效观察

    Institute of Scientific and Technical Information of China (English)

    李丽丽

    2015-01-01

    目的研究半导体激光经鼻治疗小儿腺样体肥大的疗效,探索物理治疗在小儿腺样体肥大治疗中的效果。方法每次每侧鼻腔半导体激光经鼻照射治疗20min,1次/d,连续7d为1疗程。结果64例小儿腺样体肥大患儿,年龄3~8岁。治疗前均用前鼻镜检查,其中经前鼻镜目视发现腺样体肥大患儿39例,其余鼻腔分泌物堵塞,不能直视腺样体者用CT检查示腺样体肥大,堵塞鼻咽腔70%以上且睡眠时打鼾症状明显、不伴有副鼻窦炎者均给予单纯半导体激光经鼻治疗。结论半导体激光经鼻治疗小儿腺样体肥大疗效确切。%Objective To study the semiconductor laser nasal treatment the curative ef ect of infantile adenoid hypertrophy,explore the physical therapy in the treatment of infantile adenoid hypertrophy. Methods 64 cases of children with infantile adenoid hypertrophy,aged 3 to 8.Treatment are made before the nasal endoscopy,of which the former rhinoscope visual found that children with adenoid hypertrophy were 39 cases,the rest of the nasal secretions,who can't look straight into adenoidectomy with CT examination in adenoid hypertrophy,jam,more than 70%of the nasopharyngeal cavity and sleep snoring symptoms,without vice sinusitis were given your nasal passages of semiconductor laser therapy alone.Methods Each side nasal cavity semiconductor laser ir adiation nasal treatment for 20 minutes,once a day,seven days for a course of treatment.Conclusion Your nasal passages of semiconductor laser treatment curative ef ect is infantile adenoid hypertrophy.

  2. Study of Relationship Between 64-slice CT Features and Chronic Rhino Sinusitis in Children with Adenoid Hypertrophy%儿童腺样体肥大的CT表现与慢性鼻-鼻窦炎的关系

    Institute of Scientific and Technical Information of China (English)

    王乐秋; 张瑞迪; 隋萍萍; 马秀凤; 李丽娟

    2013-01-01

    Objective To study the relationship between 64-slice CT features and chronic rhino sinusitis in children with adenoid hypertrophy. Methods The noses of 125 children with adenoid hypertrophy were scanned by 64-slice CT. The relationship between incidence of chronic rhino sinusitis and the volume of adenoid measured by CT was analyzed statistically. Results Mild adenoid hypertrophy (A/N 0.05). While the moderate or severe hypertrophy is (A/N ≥ 0.61) more likely to cause chronic rhino sinusitis. There is positive correlation between the hypertrophy degree and the incidence of chronic rhino sinusitis(P<0.05). Conclusion The CT features of adenoid hypertrophy is closely related to chronic rhino sinusitis. It is of great significance to treat adenoid hypertrophy timely for the prevention of chronic rhino sinusitis.%目的 探讨腺样体肥大儿童中慢性鼻-鼻窦炎发病情况与其CT表现的关系.方法 对125例腺样体肥大的儿童行常规鼻部64排CT检查,统计分析慢性鼻-鼻窦炎的发生率与CT测量腺样体体积的关系.结果 腺样体轻度肥大(A/N<0.6)与慢性鼻-鼻窦炎发病与否无关(P >0.05).腺样体中重度肥大(A/N≥0.61)的患儿更易合并慢性鼻-鼻窦炎,且呈正相关关系(P <0.05).即随着腺样体肥大程度的增加,慢性鼻-鼻窦炎发病率亦增加.结论 儿童腺样体肥大CT表现与慢性鼻-鼻窦炎密切相关,及时治疗腺样体肥大对预防及治疗慢性鼻-鼻窦炎具有十分重要的意义.

  3. The clinic analysis of adenoid cystic carcinoma of oral- maxillaface%口腔颌面部腺样囊性癌的临床分析

    Institute of Scientific and Technical Information of China (English)

    李永太

    2002-01-01

    目的探讨口腔颌面部腺样囊性癌(adenoid cystic carcinoma,ACC)的诊断、治疗及其预后.方法回顾性分析19例ACC的生长部位、治疗方法及预后.结果首次手术复发率为43%,再次手术全部复发;3、5、10年生存率手术加放疗分别为100%、80%、60%,单纯手术者分别为75%、50%、0%.结论ACC的局部复发率较高,早期发现、综合治疗效果较好,颌下腺区ACC预后较好,强调首次手术治疗的彻底性.

  4. Clinicopathological Analysis Of Orbital Adenoid Cystic Carcinoma%眼眶腺样囊性癌临床病理分析

    Institute of Scientific and Technical Information of China (English)

    李平惠; 李涛; 夏瑞南

    2003-01-01

    目的:探讨眼眶腺样囊性癌(adenoid cystic carcinoma ACC)的临床特征及病理组织学特点.方法:回顾性分析20例ACC患者的临床及病理资料.结果:ACC主要表现为眶内包块(20/20)、眼球突出移位(14/20)、眼球运动障碍(14/20)、眶周疼痛(13/20)等;病理组织学分5型:筛状型、管状型、实体型、粉刺型和硬化型.结论:ACC的临床特征有助于其诊断,最终确诊有赖于病理组织学检查.

  5. 间接喉镜明视下经鼻腔行腺样体切除术%Adenoid hypertrophy exsection through nasal cavity under indirect laryngoscopy

    Institute of Scientific and Technical Information of China (English)

    吕怀庆; 陈彦林; 王永强

    2011-01-01

    目的 评估间接喉镜明视下经鼻底进入鼻息肉钳行腺样体切除术的疗效.方法 对80例腺样体肥大患者采用间接喉镜明视下经鼻底进入直头鼻息肉钳切除腺样体,采用双极或单极电凝经鼻或口行鼻咽部创面止血.结果 术中术野清楚,术后无出血,腺样体切除彻底,无周围正常组织损伤,无任何并发症出现.结论 间接喉镜下经鼻腔行腺样体切除术所需设备简单,易于操作,腺样体切除彻底,安全,无并发症.%Objective To evaluate curative effects of adenoidectomy in which nasal polypus forceps are put in through the nasal cavity under an indirect laryngoscope.Methods 80 patients suffering from adenoid hypertrophy were enrolled in this study.Adenoidectomy was operated on by putting nasal polypus forceps through the nasal cavity with direct vision under an indirect laryngoscope and bipolar electrocoagulation or mono-polar electro-coagulation was used to stop bleeding on the nasopharyngeal surface through the nasal cavity or oral cavity.Results The operation field was clear and the operation process was short.The adenoid was completely removed without any damage to surrounding tissues and any complications.Conclusion Adenoidectomy through the nasal cavity under an indirect laryngoscope is easy to do.

  6. Comparação entre a radiografia de cavum e a cefalométrica de perfil na avaliação da nasofaringe e das adenoides por otorrinolaringologistas Comparison between cavum and lateral cephalometric radiographs for the evaluation of the nasopharynx and adenoids by otorhinolaryngologists

    Directory of Open Access Journals (Sweden)

    Rhita Cristina Cunha Almeida

    2011-02-01

    Full Text Available INTRODUÇÃO: tanto a radiografia cefalométrica de perfil quanto a de cavum permitem a avaliação do espaço aéreo nasofaríngeo (EAN. Não é rara a solicitação dos otorrinolaringologistas de radiografia de cavum, mesmo o paciente possuindo uma cefalométrica. OBJETIVOS: objetivou-se (a conhecer quais exames os otorrinolaringologistas solicitam para avaliar o EAN; (b verificar o conhecimento da cefalométrica por otorrinolaringologistas; (c comparar a avaliação de otorrinolaringologistas nas duas técnicas radiográficas para a medição e a visualização do EAN e da adenoide; (d correlacionar os resultados do método de inspeção visual com os da medição de Schulhof. MÉTODOS: foram obtidas, no mesmo dia, radiografias cefalométricas e de cavum de 15 pacientes respiradores bucais. Essas foram cobertas com papel cartão, deixando visível apenas o EAN e adenoides e foram avaliadas por 12 otorrinolaringologistas. Estes respondiam sobre sua familiaridade com a cefalométrica, quais exames solicitam para visualizar EAN e adenoides e se utilizam algum método de medição do grau de obstrução. Avaliavam qual das radiografias apresentava a melhor visualização da adenoide e do EAN, e classificavam o tamanho dos mesmos em pequeno, médio ou grande, através de método visual. RESULTADOS: os resultados demonstraram que todos os otorrinolaringologistas costumam solicitar a radiografia de cavum. Apenas um solicita a cefalométrica, dois estão familiarizados com essa técnica e um utiliza algum método de medição do EAN. A cefalométrica foi preferida por 49,4% dos otorrinolaringologistas, a de cavum por 22,8%, enquanto 27,8% não observaram diferença entre ambas. Foi encontrada baixa correlação entre o método de medição visual e o de Schulhof.INTRODUCTION: The lateral cephalometric as well as the cavum radiograph allow the evaluation of the nasopharyngeal airway (NAW. Otorhinolaryngologists routinely use the cavum radiograph, even

  7. 学龄前儿童腺样体肥大的声导抗和DPOAE探测结果分析%Tympanometry and DPOAE analyses in preschoolers with adenoidal hypertrophy

    Institute of Scientific and Technical Information of China (English)

    魏日富; 刘平; 朱忠寿; 何观文; 蔡灿辉; 洪艺云; 张茂华

    2015-01-01

    Objective Analises of tympanometry and otoacoustic emissions results in preschool children with adenoid hypertrophy. Methods Acoustic immittance and otoacoustic emissions results and parameters were collected in 75 preschool children (aged 3-7 years) with varying degrees of adenoidal hypertrophy. Results The rates of type A immitance curve and positive acoustic reflex and average peak ear canal pressure in children with degree III adenoid hypertrophy were all lower between those with degree I or II adenoid hypertrophy (p<0.05). The rate of positive DPOAEs in children with degree III adenoid hypertrophy were also lower than those with degree I (1–8 kHz) or II (1.5-8 kHz) hypertrophy (p<0.05). In chil-dren with type A tympanograms, the rate of positive DPOAEs (0.5 – 2 kHz) in those with no acoustic reflex was lower than those with positive acoustic reflex (p <0.05). Conclusion Preschool children with adenoidal hypertrophy should re-ceive routine acoustic impedance and/or otoacoustic emission tests for early diagnosis of secretory otitis media in this popu-lation. The level of hypertrophy adenoidal can affect middle ear functions in these children, with higher levels of adenoid hy-pertrophy more likely to cause secretory otitis media of greater severities.%目的:探讨与研究学龄前儿童腺样体肥大的声导抗和耳声发射。方法选取75例3~7岁不同程度腺样体肥大儿童,依次进行声导抗和耳声发射测试,并记录结果和参数。结果腺样体Ⅲ度肥大患儿出现A型鼓室图的概率、声反射引出率、平均峰压值均明显低于I度及II度肥大患儿,差异有统计学意义(P<0.05);腺样体III度肥大患儿的DPOAE较I度肥大患儿(1~8kHz),较II度肥大患儿(1.5~8kHz)引出率低,差异有统计学意义(P<0.05);声导抗为A型的患儿中,声反射未引出者的DPOAE在0.5~2kHz区域引出率低于声反射引出者,差异有统计学意义(P<0.05)。结论

  8. 耳窥镜配合动力系统治疗小儿腺样体肥大的临床应用%Application of the children with adenoidal hypertrophy by dynamical systems and ear endoscope

    Institute of Scientific and Technical Information of China (English)

    叶刚; 李登敏; 罗文广; 邹杨; 周林路

    2011-01-01

    目的:探讨耳内镜下配合动力系统治疗小儿腺样体肥大的方法可行性及优于传统方法特点.方法:对56例、年龄3~7岁、确诊为腺样体肥大的患儿,在耳内镜明视下由鼻腔插入,配合动力系统进过鼻腔及口腔切除肥大腺样体组织.结果:56例患儿腺样体完整切除,12到24小时后取出膨胀海绵,均未见活动性出血.所有患儿术后5d治愈出院.术后5~10d检查,鼻咽部无腺样体残留、假膜生长好,鼻咽部宽敞,咽鼓管圆枕、咽口及鼻咽顶部无受损伤.术后全部患儿鼻塞症状明显减轻或消失.小儿鼾症症状大部分减轻或者消失.9例中耳炎患儿中耳腔内积液流出逐渐减少,听力提高.出院随访半年以上,伴有鼻窦炎患儿大部分症状改善,流涕减少,通气好,分泌性中耳炎患儿听力改善,腺样体肥大患儿无1例复发.讨论:耳内镜下配合动力系统治疗小儿腺样体肥大的方法因完全在明视下探作;镜体细小,经过鼻腔时对于鼻腔损伤小;病灶切除范围准确,并发症少;术后效果良好,是治疗小儿腺样体肥大的理想方法.%Objective: To investigate the ear with the endoscopic treatment of children with adenoidal hypertrophy power system feasibility and method of characteristics than traditional methods. Methods: 56 patients aged 3 to 7 years old, diagnosed with adenoid hypertrophy in children, in the ear from the nasal cavity under endoscopic view into the next, with the power system through the nose and mouth into the removal of adenoid tissue hypertrophy. Results:56 cases of complete removal of adenoids in children 12 to 24 hours after sponge removal inflation) showed no active bleeding. All patients recovered after 5 d. 5 ~ 10d after the examination, nasopharyngeal adenoids no residue, pseudomembranous growth is good, spacious nasopharynx, eustachian tube torus, pharynx, mouth and nasopharynx at the top without injured. All children with symptoms of nasal

  9. Tonsils and Adenoids

    Science.gov (United States)

    ... AcademyU Home Study Course Maintenance of Certification Conferences & Events ... a liability than an asset and may even cause airway obstruction or repeated bacterial infections. Your ear, nose, and throat (ENT) specialist ...

  10. 小儿慢性扁桃体炎腺样体肥大手术的护理体会%Pediatric chronic tonsillitis of adenoid hypertrophy surgery nursing experience

    Institute of Scientific and Technical Information of China (English)

    侯玉环

    2014-01-01

    Objective:To investigate the pediatric chronic tonsillitis children with adenoid hypertrophy surgery the clinical effect of nursing intervention. Methods: 50 cases of children with chronic tonsillitis implementation of nursing intervention in children with adenoid hypertrophy surgery. Results:All children are successful operation, after nursing intervention, no complications occurred. Conclusion: Children with chronic tonsillitis nursing intervention in children with adenoid hypertrophy surgery, has a good effect, worth clinical promotion.%目的:探讨对小儿慢性扁桃体炎腺样体肥大手术患儿实施护理干预的临床效果。方法:对50例小儿慢性扁桃体炎腺样体肥大手术患儿实施护理干预。结果:所有患儿均手术成功,经过护理干预,无并发症发生。结论:对小儿慢性扁桃体炎腺样肥大手术患儿进行护理干预,具有较好效果,值得临床推广。

  11. Diagnosis of adenoidal hypertrophy with nasopharyngeal lateral film (analysis of 118 cases)%鼻咽部侧位片对腺样体肥大的诊断意义(附118例分析)

    Institute of Scientific and Technical Information of China (English)

    李月梅; 吕新胜; 罗道宝

    2009-01-01

    目的 探讨鼻咽侧位片诊断腺样体肥大的价值.方法 采用A/n比值及平行曲线法,对儿童腺样体肥大进行诊断应用和分析.结果 118个病例中72例经手术证实,认定腺样体指数<0.60为正常,≥0.70为肥大,0.60~0.69者可结合年龄、临床症状及鼻咽镜检查进行诊断.结论 规范的鼻咽部侧位片对于腺样体肥大具有一定诊断价值.%Objective To assessment the for adenoidal hypertrophy on nasopharynx hteral films. Methods A/n ratio and the parallel curve were used to evaluate adenoidal hypertrophy in children. Results 72 cases confirmed by surgery in all, the adenoids index <0.60 was for normal, ≥0.70 for hypertrophy, 0.60 ~ 0.69 for diagnosis with age, clinical symptoms and nasopharyngoscopy examination. Conclusion Nasopharyngeal lateral film is a methed of simple and accurate diagnosis.

  12. 中医从痰论治儿童腺样体肥大概况%Overview of Treating Pediatric Adenoid Hypertrophy from Phlegm of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    张婧延; 才博华; 姜之炎

    2015-01-01

    近年来儿童腺样体肥大发病率持续上升,但治疗方法有限。从痰论治是中医治疗儿童腺样体肥大重要法则,并取得了较好的临床疗效。本文通过收集从痰论治儿童腺样体肥大的相关文献报道,对中医“从痰论治”思路进行总结综述。%The incidence of pediatric adenoid hypertrophy increases year by year. However, the treatment methods are limited. By now TCM treatment has showed significant clinical efficacy in treating pediatric adenoid hypertrophy. And phlegm could be one of the main pathogenic factors. By collecting relevant literature about TCM treatment for pediatric adenoid hypertrophy, this article summarized the thoughts of treating from phlegm based on the collection and analysis of classification of syndrome and treatment methods guided by the thoughts of treating from phlegm.

  13. Role of CDH12 siRNA on invasiveness of salivary adenoid cystic carcinoma cells%CDH12基因siRNA对涎腺腺样囊性癌细胞侵袭力的影响

    Institute of Scientific and Technical Information of China (English)

    苏柏华; 王锦锋; 佘林; 郑斐斐; 丁林灿; 卢友光

    2011-01-01

    目的:探讨钙粘素12(Cadherin 12,CDH12)对涎腺腺样囊性癌(Salivary adenoid cystic carcinoma,SACC)细胞侵袭和转移能力的影响.方法:以人涎腺腺样囊性癌高转移细胞株(Salivary adenoid cystic carcinoma cell line with high metastatic ability,SACC-M)为研究对象,利用CDH12小分子干扰RNA(Small interfering RNA,siRNA)对CDH12基因进行沉默,Western blot检测转染前后CDH12的表达变化.Cell Counting Kit-8法检测转染前后细胞的生长速度,体外侵袭实验比较细胞侵袭能力变化,体外迁移运动实验比较细胞运动能力的改变.结果:CDH12 siRNA明显下调CDH12基因的表达.CDH12表达下调后,SACC-M细胞体外侵袭能力显著降低,体外迁移运动能力明显降低.结论:CDH12明显地促进了SACC细胞的体外侵袭和迁移运动,提示CDH12可能在SACC的恶性进展中起着重要作用.%Objective:To study the effect of CDH12 on invasion and migration of human salivary adenoid cystic carcinoma cells in vitro. Methods:The highly metastatic human salivary adenoid cystic carcinoma cell line SACC-M was transfected by CDH12 siRNA to silence CDH12 gene. The protein expression of CDH12,before and after siRNA transfection,was examined by Western blot. Cell growth rate was determined with Cell Counting Kit-8.At the same time,the invasive capability and migration capability were evaluated by tumour invasion assay and migration assay, respectively. Results CDH 12 siRNA transfection specifically down-regulated the CDH 12 protein in SACC-M cells. The downregulation of CDH12 supressed the invasive capability and migration capability of SACC-M cells. Conclusion:CDH12 obviously promotes the invasion and migration of SACC cells in vitro. These results suggest that CDH12 may play an important role in the malignant progression in salivary adenoid cystic carcinoma.

  14. 腺样体肥大对前牙反牙合儿童颌骨发育影响的研究%Effect of adenoid hypertrophy on maxilla and mandible growth of children with anterior crossbite

    Institute of Scientific and Technical Information of China (English)

    冯海亮; 柯杰; 赵桂芝; 张艳迪; 张容秀; 林泉宏

    2016-01-01

    目的:研究腺样体肥大对前牙反牙合儿童颌骨发育的影响。方法:从门诊正畸求治的乳牙期和混合牙列早期前牙反牙合儿童中,选取腺样体肥大的儿童16例作为实验组,同时选取无腺样体肥大的儿童20例作为对照组,进行X线头影测量研究。结果:腺样体肥大组SNA和SNB值较对照组小,MP-FH、MP-SN、Y轴角及ANS-Me值较对照组大,差异均具有统计学意义,而其余指标比较,差异均无统计学意义。结论:腺样体肥大影响前牙反牙合儿童颌骨发育,可能导致骨性反牙合和骨性开牙合,提高对腺样体肥大致病作用的认识,有助于正畸临床对前牙反牙合儿童综合矫治计划的制定。%ObjectiveTo study the effect of adenoid hypertrophy on maxilla and mandible growth of anterior crossbite in children.Methods Sixteen children with adenoid hypertrophy were selected as the experimental group, and another twenty children with no adenoid hypertrophy as the control group. All cases were selected from children with anterior crossbite in deciduous and early mixed dentition.ResultsThere was signiifcant difference in SNA, SNB, MP-FH, MP-SN, Y-axis angle and ANS-Me length between two groups.Conclusion Adenoid hypertrophy has great influence on maxilla and mandible development. The diagnosis of adenoid hypertrophy helps make plan for children with anterior crossbite in orthodontic treatment.

  15. 糠酸莫米松治疗小儿腺样体肥大的短期疗效评估%The Short-Term Efficacy of Mometasone Furoate on Infantile Adenoid Hypertrophy

    Institute of Scientific and Technical Information of China (English)

    陶佳; 罗仁忠; 温瑞金; 周丽枫; 王洁

    2013-01-01

    目的:评估鼻用激素(糠酸莫米松)治疗单纯腺样体肥大的短期疗效,观察鼻用激素治疗的安全性.方法:采用随机对照的方法将就诊的腺样体肥大患儿分为两组,实验组42例用糠酸莫米松喷鼻,对照组41例用生理盐水喷鼻,分别在治疗前和治疗两个月后比较实验组和对照组患儿OSA-18评分和内镜下腺样体大小.结果:实验组鼻用激素治疗2个月后无1例患儿出现并发症,与治疗前相比OSA-18评分总分明显降低(P<0.05);内镜下观察腺样体较治疗前缩小,实验组与对照组相比腺样体鼻堵塞程度改善更显著.结论:鼻用激素治疗腺样体肥大短期内能缩小腺样体,改善临床症状,是有效的保守治疗方法.%Objective; To evaluate the short-term efficacy of intranasal corticosteroid (mometasone furoate) on infantile adenoidal hypertrophy and observe the safety of this treatment. Methods; A randomized, placebo-controlled study was done. The experimental group received mometasone, and the control group received physiological saline. The OSA-18 score and adenoid size in endoscopic examination of these two groups were compared before and after two-month treatment. Results:After two-month treatment, compared with the control group, the OSA-18 score and the adenoid size in endoscopic examination were decreased in the experimental group significantly(P<0.05). Conclusions; Mometasone furoate aqueous nasal spray may be helpful in reducing adenoid size and improving clinical symptoms in the treatment of infantile adenoidal hypertrophy.

  16. 儿童腺样体肥大的术式探讨%Comparison of three surgical techniques in the treatment of pediatric adenoid hypertrophy

    Institute of Scientific and Technical Information of China (English)

    李琰; 孙昌志; 周丽枫; 曾清香

    2016-01-01

    目的:比较间接鼻咽镜下低温等离子射频消融术、鼻内镜辅助经口低温等离子消融术及鼻内镜经口电动吸引切割术治疗儿童腺样体肥大的临床疗效。方法选择行腺样体切除术180例患儿,随机分为 A、B、C 共3组,每组60例患儿。A 组采用间接鼻咽镜下低温等离子射频消融术、B 组采用鼻内镜辅助经口低温等离子消融术、C 组采用鼻内镜经口电动吸引切割术。比较3组术前准备时间、手术时间、术中出血量、术后疼痛时间及并发症等情况。结果 A 组术前准备时间最短,与其他2组比较差异均有统计学意义(P 均<0.01);A、B 组手术时间均短于 C 组(P 均<0.01)、术中出血量亦少于 C 组(P 均<0.01);3组术后疼痛比较差异无统计学意义(P >0.05)。结论与鼻内镜辅助经口低温等离子消融术及鼻内镜经口电动吸引切割术比较,间接鼻咽镜下低温等离子消融术治疗儿童腺样体肥大,具有术前准备简单、手术时间短、出血量少、不增加术后疼痛等优点。%Objective To compare the clinical efficacy among indirect nasopharyngoscope-guided ra-diofrequency coblation,transoral endoscopy-guided radiofrequency coblation and transoral power-assisted endo-scopic adenoidectomy in treating the pediatric adenoid hypertrophy.Methods A total of 1 80 children diag-nosed with adenoidal hypertrophy were enrolled and divided into groups A,B and C (n =60 for each group). In group A,patients underwent indirect nasopharyngoscope-guided radiofrequency coblation,transoral endosco-py-guided radiofrequency coblation in group B and transoral power-assisted endoscopic adenoidectomy in group C.Preoperative preparation time,operation time,intraoperative hemorrhage volume,postoperative pain dura-tion and postoperative complications were statistically compared among three groups.Results Preoperative preparation time in group A was

  17. OSA-18量表评估腺样体肥大儿童生活质量%Assessment ofquality of life in children with adenoid hypertrophy by OSA-18 questionnaire

    Institute of Scientific and Technical Information of China (English)

    龙朝庆; 颜永毅; 容庆丰

    2015-01-01

    目的:采用儿童阻塞性睡眠呼吸暂停低通气综合征(OSAHS)疾病特异性生活质量调查(OSA-18)量表,评估腺样体肥大患儿生活质量,以期了解 OSA-18量表是否可作为临床评估腺样体肥大患儿生活质量状况的指标。方法对符合入选标准的腺样体肥大患儿56例,行电子鼻咽镜及多导睡眠监测(PSG)检查,并采用 OSA-18量表对其进行生活质量评估,分析腺样体肥大病情程度与 OSA-18评分的相关性。结果80.36%的腺样体肥大患儿生活质量受到明显影响,OSA-18总体评分为“中度+重度”。OSA-18总体评分与呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO2)及腺样体大小存在明显的相关关系。结论腺样体肥大程度与 OSA-18评分之间存在相关性,OSA-18量表评分可作为临床评估腺样体肥大患儿生活质量状况的指标。%Objective To investigate the value of OSA-18 questionnaire in assessment of quality of life in the children with adenoid hypertrophy.Methods Electronic nasopharyngoscopy and polysomnography (PSG)were underwent in 56 children with adenoid hypertrophy,and their quality of life were evaluated by OSA-18 questionnaire.The correla-tions between adenoid hypertrophy and OSA-18 scores were analyzed.Results The quality of life in 80.36% children with adenoid hypertrophy were significantly affected.Their OSA-18 total score were moderate and severe.There was significant correlation between OSA-18 total score and apneahypopneaindex(AHI),lowestoxygen saturation(LSaO2 ), and adenoid size.Conclusion There is an obvious correlation between adenoid size and OSA-18 score.OSA-18 ques-tionnaire can be used asan indicatorin assessment of quality of life in the children with adenoid hypertrophy.

  18. Relationship between Nasopharyngeal Lateral Film and Adenoid Hypertrophy%鼻咽部X线侧位片A/N值与儿童腺样体肥大的关系

    Institute of Scientific and Technical Information of China (English)

    杨景泓

    2014-01-01

    目的:分析鼻咽部X线侧位片A/N值与儿童腺样体肥大的关系,探讨其在儿童腺样体肥大诊断中的应用价值。方法:回顾性分析105例怀疑腺样体肥大儿童的鼻咽部侧位片等临床资料,测量腺样体厚度、鼻咽腔宽度及后气道宽度(PAS),并计算腺样体指数,分析A/N值与儿童腺样体肥大的关系。结果:A/N≤0.6者20例,0.6adenoid hypertrophy,discuss the diagnostic value of nasopharyngeal lateral film for pediatric adenoid hypertrophy.Method:Retrospective analysis 105 cases of suspected of adenoid hypertrophy in children of nasopharyngeal lateral slice and other clinical data,measure the thickness and width of nasopharyngeal adenoid body and after airway width (PAS),and calculate the adenoidectomy index,analysis of the A/N value and the relationship between adenoid hypertrophy in children.Result:The ratios of A/N≤0.6 were found in 20 cases,0.6adenoid hypertrophy are positively correlated,observation and diagnosis of adenoid hypertrophy in children is simple and accurate method.

  19. Adenoid Cystic Carcinoma Metastatic to the Pituitary: A Case Report and Discussion of Potential Diagnostic Value of Magnetic Resonance Elastography in Pituitary Tumors.

    Science.gov (United States)

    D Hughes, Joshua; Retzlaff, Amber; Sims, John; O'Brien, Erin; Giannini, Caterina; Huston, John; Van Gompel, Jamie J

    2016-07-01

    Adenoid cystic carcinoma (ACC) is an exocrine gland tumor accounting for approximately 10%-15% of all epithelial salivary neoplasms and occurs most often in the parotid and submandibular glands. Metastatic pituitary tumors are rare, and there is only 1 previously reported case of parotid ACC metastatic to the pituitary. Magnetic resonance elastography (MRE) is a dynamic magnetic resonance imaging (MRI)-based technique that measures the propagation of mechanically induced shear waves through a particular tissue to determine stiffness and offers a method to evaluate tissue consistency. We present the case of a 72-year-old woman with a remote history of parotid gland ACC and subsequent lung metastases presented after a fall that resulted in facial trauma. A non-contrast head computed tomography scan revealed a sellar/suprasellar mass, and follow-up MRI revealed a well-defined, enhancing 3.8-cm lesion. MRE showed the tumor to be firm. The tumor was resected through a transsphenoidal approach and was consistent with the MRE findings. Pathology returned as metastatic ACC. We report the second case of ACC metastatic to pituitary and the first firm pituitary tumor found by MRE and discuss the potential diagnostic value of MRE in pituitary lesions.

  20. Influence of Ginkgo biloba extract on the proliferation, apoptosis of ACC-2 cell and Survivin gene expression in adenoid cystic carcinoma of lacrimal gland

    Institute of Scientific and Technical Information of China (English)

    Li-Xiao Zhou; Yu Zhu

    2012-01-01

    Objective: To explore the influence of extract of Ginkgo biloba (EGB) on the proliferation, apoptosis of ACC-2 cell and Survivin gene expression in adenoid cystic carcinoma (ACC) of lacrimal gland. Methods:ACC-2 cell in human with ACC of lacrimal gland was in vitro cultured. MTT method was used for cell proliferation detection. Annexin V/PI double-staining flow cytometer was used to detect cell apoptosis and cell cycle. Survivin gene expression was analyzed by RT-PCR and Western blotting. Results: EGB had inhibitory effect on the proliferation of ACC-2 cell with significant dose-effect relationship, and there was statistical difference when compared with the control group (P<0.01). The inhibitory concentration 50 % (IC50) is 88 mg/L. The flow cytometer test indicated that EGB can gradually increase ACC-2 cell in G0-G1 stage and decrease it in G2-M and S stage. With the increase of dose, the apoptosis rate of ACC-2 cell was obviously increased (P<0.05 or P<0.01). EGB had certain inhibitory effect on Survivin gene expression of ACC-2 cell, and Survivin gene expression was decreased with the increasing of the EGB concentration (P<0.01). Conclusions:EGB can effectively inhibit Survivin gene expression of ACC-2 cell in human with ACC of lacrimal gland, induce the apoptosis of ACC-2 cell and inhibit tumor cell proliferation.

  1. Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, L.C.; Huang, S.Y.; Zhang, D.S.; Zhang, S.H.; Li, W.G.; Zheng, P.H.; Chen, Z.W. [Shandong Provincial Hospital Affiliated to Shandong University, Department of Oral and Maxillofacial Surgery, Jinan, China, Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan (China)

    2014-03-03

    Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. The expression and prognostic significance of beclin 1 in head and neck adenoid cystic carcinoma (ACC) are largely unexplored. Therefore, we investigated the expression of beclin 1, Bcl-2, and p53 in head and neck ACC tissue. Tissue samples from 35 cases (15 females, 20 males) of head and neck ACC were utilized for immunohistochemistry. Beclin 1 expression was observed in 32 cases (91.4%) and considered to be high in 15 cases (42.9%) and low in 20 cases (57.1%). Beclin 1 expression was significantly correlated with a histological growth pattern (P=0.046) and histological grade (P=0.037). Beclin 1 expression was inversely correlated with Bcl-2 expression (P=0.013) and significantly associated with overall survival (P=0.006). Bcl-2 and p53 expression were observed in 21 cases (60.0%) and 16 cases (45.7%). Bcl-2 expression was significantly correlated with perineural invasion (P=0.041) and not associated with overall survival (P=0.053). p53 expression was directly correlated with beclin 1 expression (P=0.044). Our results indicated that beclin 1 may be a novel, promising prognostic factor for clinical outcome in head and neck ACC patients and may play a part in the development of head and neck ACC by interacting with Bcl-2 and p53.

  2. Effects of Obstructive Sleep Apnea in Children as a Result of Adenoid and/or Adenotonsillar Hypertrophy on Maternal Psychologic Status.

    Science.gov (United States)

    Ozbay, Isa; Ozturk, Ahmet; Kucur, Cuneyt; Erdogan, Onur; Oghan, Fatih

    2015-11-01

    The authors aimed to evaluate the effects of obstructive sleep apnea in children as a result of adenoid and/or adenotonsillar hypertrophy on maternal psychologic status. The study sample comprised the mothers of 66 children aged 3 to 15 years (mean age: 7.55 ± 2.94 years) who were scheduled to undergo curette adenoidectomy or adenotonsillectomy because of airway obstruction. The mothers completed the 14-item Hospital Anxiety and Depression Scale (HADS), 20-item State-Trait Anxiety Inventory-1 (STAI-1), and 20-item State-Trait Anxiety Inventory-2 (STAI-2) questionnaires before the operation and 10 days afterwards. Mothers who were under psychiatric treatment or declined to fill the questionnaires were excluded from the study. The results obtained postoperatively by day 10, when all the children had considerable improvement in their breathing, were analyzed as control data. The mean postoperative HAD-A and HAD-D scores of the mothers were significantly lower than the mean preoperative scores (P < 0.001). Mothers' mean STAI-1 and STAI-2 scores were also significantly lower postoperatively (P < 0.001). Pediatric adenoidectomy or adenotonsillectomy to relieve airway obstruction has a beneficial effect not only on the health of pediatric patients but also on the psychologic status of their mothers.

  3. EGF/EGFR 调控 MMP-2在腺样囊性癌中的表达%The Study of EGF/EGFR Induced MMP-2 Expression in Adenoid Cystic Carcinoma

    Institute of Scientific and Technical Information of China (English)

    高杨; 张明; 宫春梅

    2015-01-01

    [ ABSTRACT] Objective To research the regulation of matrix metalloproteinases-2( MMP-2) in adenoid cystic carcinoma which in-duced by EGF/EGFR,and to further explore the mechanisms of the MMP-2 in occurrence,development and metastasis of the adenoid cystic carcinoma.Methods First of all immunohistochemistry was used to observe the expression and distribute of EGFR and MMP-2 in the normal salivary gland and adenoid cystic carcinoma;the real time RT-PCR was used to observe the expression of MMP-2 mRNA in adenoid cystic carcinoma induced by different doses of EGF,then we analysized the expression of MMP-2 mRNA induced by EGF which acted by EGFR in-hibitor;at the last we observed that EGF induced the expression of MMP-2 protein in adenoid cystic carcinoma by western blot.Results Im-munohistochemistry showed that EGFR and MMP-2 have the positive expressions in adenoid cystic carcinoma,while have the negative expres-sions in normal salivary gland;the real time RT-PCR showed that EGF can increase the expression of MMP-2 in adenoid cystic carcinoma,es-pecially in 20μg/L.It also was found that EGFR inhibitor can suppress the increased expression of MMP-2 induced by EGF.The western blot was used to verify that the expression of MMP-2 protein in adenoid cystic carcinoma was induced by EGF.Conclusion The expression of MMP-2 in adenoid cystic carcinoma was induced by EGF,the new theoretical guidance was taken to the clinical treatment of adenoid cystic carcinoma.%目的:通过研究表皮生长因子及其受体(EGF/EGFR)调控基质金属蛋白酶-2(MMP-2)在腺样囊性癌细胞中的表达,为进一步探讨MMP-2在腺样囊性癌发生、发展、转移过程的机制奠定基础。方法应用免疫组织化学SP法检测正常涎腺及腺样囊性癌组织中EGFR和MMP-2的表达分布情况;利用定时定量RT-PCR法检测不同剂量的EGF调控MMP-2 mRNA在腺样囊性癌细胞中的表达水平,分析EGFR阻断剂作用下EGF调控MMP-2 mRNA的表

  4. 阴囊部皮肤原发性腺样囊性癌1例报告及文献复习%Primary cutaneous adenoid cystic carcinoma of skin in the scrotum : A case report and literature review

    Institute of Scientific and Technical Information of China (English)

    李东斌; 王益华; 吴鸿雁; 武慧娟

    2012-01-01

    Objective: To study clinical pathologic features, immunohistochemistry and distinguish diagnosis of the primary cutaneous adenoid cystic carcinoma of skin in the scrotum. Methods: One case of primary cutaneous adenoid cystic carcinoma of skin in the scrotum was clinically, histopathologically, and immunohistochemically studied, and the related literatures were reviewed. Results: Cutaneous adenoid cystic carcinoma of skin is rare and found in any location of skin except palm of hand and sole of foot, with a strong predilection for middleaged and elderly. Primary cutaneous adenoid cystic carcinoma of skin in the scrotum has not been reported, the tumor showed predominantly in a sieve - like pattern, the cystic pseudoglandular spaces were filled with secretions that was Alcian blue positive, the tumor nests were surrounded by a eosinophilic hyaline basement membrane - like material that was periodic acid -Schiff( PAS )positive. Immunohistochemistry showed positive reaction with cytokeratin -7,S - 100, epithelial membrane antigen( EMA )and p63. Conclusion: Primary adenoid cystic carcinoma of skin in the scrotum is a rare tumor with good prognosis, its light microscopy and immunohistochemistry features is similar with salivary adenoid cystic carcinoma,an indolent but progressive course is characteristic of this tumor.%目的 探讨原发阴囊部皮肤腺样囊性癌的临床病理特点,免疫组化及鉴别诊断要点.方法 报道1例原发阴囊部皮肤腺样囊性癌的临床、病理组织学形态和免疫组化特点,并复习相关文献对以上特点进行分析.结果 皮肤的腺样囊性癌较少见,可发生于除掌跖以外的任何部位,中老年好发,平均发病年龄为59岁.原发阴囊部皮肤腺样囊性癌未见报道,镜下肿瘤组织形成特殊的筛状结构,囊腔内常含有阿辛兰(pH5.2)阳性的透明质酸和硫酸化的酸性黏蛋白,瘤细胞间和小叶间周围可见透明嗜酸性基底膜物质的沉积,PAS

  5. Adenoid cystic carcinoma of the breast: a clinicopathological analysis of 18 cases%乳腺腺样囊性癌18例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    徐炼; 魏兵; 步宏; 王剑威; 张璋; 陈卉娇; 张红英; 陈敏

    2012-01-01

    Purpose To shirty the clinicopathological and immunohistochemical features and differential diagnosis of adenoid cystic carcinoma of the breast. Methods 18 patients with breast adenoid cystic carcinoma were studied by means of clinical and follow-up data, light microscopy and immunohistochemistry. Results All 18 patients of breast adenoid cystic carcinoma were female, age from 29 -80. The tumor comprised of cribriform, trabecular-tubular and solid structures. All glandular epithelium expressed CK7, CK5/6 and CD117, myoepithelium expressed SMA and p63, basal-like cell expressed CK, p63 and CD117 at different levels. 2 patients were confirmed local recurrence. All patients were alive during the follow-up. Conclusions Breast adenoid cystic carcinoma is a kind of morphologically heterogeneous neoplasm. The glandular epithelium, myoepithelium and basal-like cell have distinct immunohistochemical characteristics. The solid variant of mammary adenoid cystic carcinoma with basaloid features is maybe more aggressive.%目的 探讨乳腺腺样囊性癌(adenoid cystic carcinoma of the breast,ACC)的临床病理特征、免疫表型及其鉴别诊断.方法 复习18例ACC的临床病理资料,观察肿瘤的组织形态学及免疫表型特点.同时对患者进行随访获取预后信息.结果 18例ACC患者均为女性,年龄29~80岁.肿瘤大体上多界限清楚,镜下呈浸润性生长,主要由筛状、管状-梁索状、实体和微囊结构组成.肿瘤成分包括腺上皮、肌上皮、基底样细胞和细胞外基质.肿瘤的腺上皮成分表达CK7、CK5/6和CD117,肌上皮成分表达SMA和p63,基底样细胞不同程度表达CK5/6、p63和CD117.随访期内有2例患者肿瘤局部复发,无患者死亡.结论 ACC是一组具有形态学异质性的肿瘤,其腺上皮、肌上皮和基底样细胞成分的免疫表型各有特点,联合运用CK7、CK5/6、p63、SMA和CD117有助于诊断与鉴别诊断.ACC预后良好,具有基底

  6. 鼻内镜下电动切割器治疗腺样体肥大36例%Endoscopic electric cutters in the treatment of 36 cases of adenoidal hypertrophy

    Institute of Scientific and Technical Information of China (English)

    王静; 吴加亮; 尹霞

    2014-01-01

    目的:探讨鼻内镜下电动切割器治疗腺样体肥大的临床疗效。方法将36例接受腺样体切除术治疗腺样体肥大的患者根据随机数字表法分为观察组与对照组,观察组采用鼻内镜下电动切割器治疗,对照组则采用传统腺样切除术治疗,比较两组治疗效果。结果观察组彻底切除腺样体所需时间为(10.65±2.38)min,术中出血量(28.82±0.98)mL,并发症发生率为0.00%,与对照组比较差异均有统计学意义(t=25.93、31.79,χ2=3.92,均P<0.05);观察组重度疼痛1例,低于对照组的9例(χ2=8.86,P<0.05);观察组总有效率为94.45%,显著高于对照组的55.55%(χ2=7.26,P<0.05)。结论相比于传统腺样体切除术治疗,采用鼻内镜下电动切割器治疗腺样体肥大能在显著减小术中出血量及并发症发生率的同时改善患者疼痛感,提高临床疗效,值得在临床上进一步推广。%Objective To explore the efficacy of endoscopic electric cutters in the treatment of adenoidal hypertrophy .Methods 36 patients who underwent adenoidectomy treatment of adenoid hypertrophy were divided into the observation group and control group according to the random number table .The observation group was taken endo-scopic electric cutters treatment , the control group was taken traditional adenoid removal treatment .The therapeutic effect of the two groups was compared .Results In the observation group,the total time required for removal of the adenoids was (10.65 ±2.38)min,blood loss was (28.82 ±0.98)mL,compared with the control group,there were significant differences(t=25.93,31.79,χ2 =3.92,all P<0.05).In the observation group,there was 1 case had severe pain,but in the control group,there were 9 cases,the difference was significant (χ2 =8.86,P<0.05).In the observation group,the total effective rate was 94.45%,which was significantly higher than 55.55% in

  7. 儿童腺样体肥大的影像学检查方法对比研究%Comparative study on different imaging technologies in the diagnosis of children with adenoid hypertrophy

    Institute of Scientific and Technical Information of China (English)

    刘国标; 李沁梅; 黄慈花

    2011-01-01

    目的 探讨不同影像学技术(DR、CT及MR)在儿童腺样体肥大诊断中的临床应用价值.方法 经临床确诊腺样体肥大儿童72例,50例使用DR摄常规鼻咽部侧位片,12例使用CT检查,10例使用磁共振成像扫描,通过测量腺样体-鼻咽腔比率(A/N比值),评估腺样体肥大情况.结果 DR、CT、MR均可获得鼻咽部软组织的清晰影像资料,通过测量A/N比值,可以评价鼻咽腔变窄程度.CT、MR可直接显示腺样体大小、形态及并发症.结论 使用DR摄鼻咽侧位片,患儿容易接受,是便捷、实用的测定儿童腺样体肥大的方法,对儿童腺样体肥大的诊断具有重要的临床价值.CT、MR测量儿童腺样体大小较DR更准确并且能显示并发症,有助于术前检查.其中MR具有无辐射、直接三维成像及软组织分辨率高的优点,在经济允许的情况下,是术前评估的首选影像学检查.%Objective To investigate the clinical value of different imaging technology [digital radiography (DR),computer tomography (CT) and magnetic resonance imaging (MRI)] in the diagnosis of children with adenoid hypertrophy.Methods 72 cases with adenoid hypertrophy were recruited.50 cases were examined by DR,12 cases were examined by CT examination,10 cases were examined by magnetic resonance imaging.The sizes of adenoid tonsils were estimated by adenoid-nasopharynx ratio(A / N)Results DR,CT and MRI can obtain clear images of nose pharynx ministry.The narrowed degree of nasopharynx lumen can be accurately evaluated by A/N.CT and MRI can directly display adenoid shape,size and complications.Conclusions DR of nose pharynx is a convenient and practical measuring for being easily accepted by children.DR has an important clinical value.CT and MRI are more accurate in measuring adenoid size and can display the complications to help preoperative examination.MR has no radiation,has high resolution of soft tissue and advantages of direct 3D imaging,and it's a first choice

  8. The correlation between cognitive,intelligence and adenoid hypertrophy in children%腺样体肥大对儿童认知及智力影响的相关性研究

    Institute of Scientific and Technical Information of China (English)

    高滢; 成颖; 侯瑾; 赵红霞; 王晓娟; 祝康; 闫静; 罗花南; 许珉; 王波涛

    2015-01-01

    目的:探讨儿童腺样体肥大与认知及智力的相关性。方法:选择腺样体肥大患儿52例作为肥大组,某幼稚园健康儿童59例作为对照组。所有研究对象由被调查者的父母填写C o n‐ner’s量表了解其认知情况,5.5岁以上儿童进行标准型瑞文智力测验了解智力发育情况。肥大组患儿拍摄鼻咽侧位片,根据A/N比率将其分为4组,进行组间比较。结果:①肥大组与对照组认知比较:Conner’s量表总评分,肥大组总分高于对照组( P<0.05);按A/N分组后比较:腺样体肥大程度与总评分呈正相关;②肥大组与对照组儿童智力对比差异无统计学意义(P>0.05)。结论:腺样体肥大的儿童认知能力较正常儿童差,并且随着腺样体肥大程度的增加其认知能力受影响越明显;但智力无明显差异。%Objective:The purpose of this study was to prove the correlation between adenoid hypertrophy and cognitive and intelligence .Methods :52 children with adenoid hypertrophy were selected as adenoid hypertrophy group ,at the same time ,59 healthy children were chosen as control group .All the children’s parents were asked to fill in the Parent Symptom Questionnaire (PSQ) ,the entire child who more than 5 .5 years old has to take the intelli‐gence test .After taking nasopharyngeal radiograph of hypertrophy group ,we divided these children into 4 groups , and then comparison between the groups .Results:① Through the comparison in PSQ total score between the two groups ,there was statistically significant ,we could infer that the hypertrophy group's score was higher than the con‐trol group's;grouped according to the degree of adenoid hypertrophy ,the degree of hypertrophy and total scores were positively correlated;②In intelligence tests ,the result showed no significant difference between mast group's and control groups .Conclusion:Compared with the normal children ,Children

  9. Clinical Observation of Combined Treatment of Children With Adenoid Hypertrophy%内外结合治疗小儿腺样体肥大临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    李健

    2016-01-01

    Objective Inside and outside the combined with the clinical curative effect of treatment of children with adenoid hypertrophy. Methods58 cases of children with infantile adenoid hypertrophy were select as the research object in our hospital from January to December 2015, adopt method for treatment of internal and external combination therapy, the curative effect was observed. Results58 cases after treatment, the total effective rate was 98.28%, incidence of adverse reactions to 0.Conclusion Infantile adenoid hypertrophy were treated by the combined treatment of inside and outside, can effectively improve the clinical symptoms, reduce the incidence of adverse reactions, curative effect is distinct.%目的:探讨内外结合治疗小儿腺样体肥大的临床疗效。方法选取我院2015年1~12月接收的58例小儿腺样体肥大患儿作为本次研究对象,均采用内外结合治疗的方法进行治疗,观察其疗效。结果58例患儿经治疗后,总有效率为98.28%;不良反应发生率为0。结论对小儿腺样体肥大患儿采用内外结合治疗,可有效改善患儿临床症状,降低不良反应发生率,疗效显著。

  10. 布地奈德鼻喷剂在治疗儿童腺样体肥大中的疗效分析%Efficacy Analysis of Budesonide Nasal Spray in the Treatment of Adenoidal Hypertrophy in Children

    Institute of Scientific and Technical Information of China (English)

    陆奇胜; 刘中; 刘玉媚

    2013-01-01

    Objective:To investigate the efficiency of budesonide nasal spray in the treatment of adenoidal hypertrophy in children. Methods:50 cas-es of adenoidal hypertrophy children were randomly divided into treatment group and control group, respectively treated by budesonide nasal spray and surgery, and compared the situation of efficacy, side effect and relapse in two groups. Results:The efficacy, rate of complication and relapse in treatment were all better than those in control group (P<0.05). Conclusion:It has a little side effect, a low relapse rate and great efficacy that use budesonide nasal spray to treat children’s adenoidal hypertrophy, which deserves promotion and application.%  目的:探讨布地奈德鼻喷剂治疗儿童腺样体肥大的效果。方法:将50例腺样体肥大患儿随机分为治疗组和对照组,分别行布地奈德鼻喷剂治疗和手术治疗,比较两组患儿的临床疗效、副作用及复发情况。结果:治疗组的临床疗效、并发症发生率及复发情况均优于对照组(P<0.05)。结论:使用布地奈德鼻喷剂治疗儿童腺样体肥大副作用小,复发率低,疗效肯定,值得推广应用。

  11. Curative effect of mometasone furoate aqueous nasal spray on adenoidal hypertrophy in children%糠酸莫米松治疗小儿腺样体肥大的疗效观察

    Institute of Scientific and Technical Information of China (English)

    薛倩; 张瑞林; 胡纯红; 张晶

    2012-01-01

    Objective To study the therapeutic effect of adenoidal hypertrophy in children treated with mometasone furoate aqueous nasal spray. Methods 65 cases with adenoidal hypertrophy were randomly divided into two groups, treatment group (35 cases) for mometasone furoate aqueous nasal spray and nasal irrigation and control group (30 cases) for ephedrine and nasal irrigation. The efficacy was observed following-up 3 months Results The total effective rate in the treatment group (65. 75%)was higher than that in the control group with significant difference (P<0. 05). Conclusion Mometasone furoate aqueous nasal spray can reduce the severity symptoms in children with adenoidal hypertrophy.%目的 观察糠酸莫基松治疗小儿腺样体肥大的临床效果.方法 将65例腺样体肥大病例随机分为治疗组35例和对照组30例,治疗组使用糠酸莫米松喷鼻十鼻腔冲洗,对照组用麻黄素滴鼻+鼻腔冲洗.随访3个月,比较两组的疗效.结果 治疗组23例有效,总有效率65.7%.12例无效;对照组12例有效,总有效率40.0%,治疗组总有效率高于对照组,差异有统计学意义(P<0.05).结论 糠酸美米松鼻腔局部用药可以改善临床症状,是治疗儿童腺样体肥大的有效方法,是部分腺样体肥大患儿保守治疗的一种选择.

  12. Nasal endoscopic plasma treatment in 90 cases of adenoid hypertrophy in children%鼻内镜下等离子治疗腺样体肥大90例

    Institute of Scientific and Technical Information of China (English)

    王丽鸣

    2013-01-01

    objective:to observe the nasal endoscopic plasma radiofrequency treatment at low temperature of adenoid hypertrophy in children of efficacy and safety. Methods:a retrospective analysis of the fiber nasopharyngeal endoscopy diagnosed as children of adenoid hypertrophy in 90 cases of patients, the endotracheal intubation and vein compound general anesthesia, in diameter 4 mm nasal endoscopic down low temperature plasma ablation therapy. Results:al cases adenoidectomy clean, no bleeding and eustachian tube damage, and other complications. Were fol owed up for 6 months without recurrence. Conclusion:nasal endoscopic treatment of low temperature plasma ablation of adenoid hypertrophy in children is a safe, simple and effective method.%目的:观察鼻内镜下低温等离子消融术治疗儿童腺样体肥大的疗效和安全性。方法:回顾性分析经纤维鼻咽镜检查确诊为儿童腺样体肥大患者90例,采用气管插管加静脉复合全身麻醉,在直径4mm鼻内镜下行低温等离子消融治疗。结果:全部病例腺样体切除干净,无出血及咽鼓管损伤等并发症。随访6个月无复发。结论:鼻内镜下等离子低温消融治疗儿童腺样体肥大是一种安全、简捷、有效的方法。

  13. 113 Cases on Resection of Adenoidal Hypertrophy in Children by Nasal Endoscope%鼻内镜下儿童腺样体切除术113例报道

    Institute of Scientific and Technical Information of China (English)

    丁元吉; 王红; 张利

    2013-01-01

    Objective To investigate the clinical effect of adenoidal hypertrophy resection in children by nasal endoscope with oral incision approach. Methods Retrospective analysis 113children with adenoid hypertrophy were treated using dynamic cutter with an oral incision approach under nasal endoscope. Compare the clinical effects with the traditional surgery group. Results In the revisit of 1 year, The surgery eliminated snoring and nasal obstruction. All the patients had no other complications such as epistaxis, injury of nasal mucosa, torus tubarius stricture,synechia nasal, after operation. Conclusion The resection of adenoidal hypertrophy in children by nasal endoscope with oral incision approach has the following advantages:relieving nasal obstruction, small trauma, less complication and better clinical effects.%  目的探讨鼻内镜下经口儿童腺样体切除术的疗效。方法回顾分析腺样体肥大患儿113例,在鼻内镜直视下,经口电动切削器切除腺样体,对其疗效与传统术式进行比较。结果术后随访1年,全部患儿术后打鼾、鼻塞等症状消失,无出血、鼻腔黏膜损伤、咽鼓管口狭窄、鼻腔粘连等并发症。结论鼻内镜下经口行腺样体切除术能彻底解除鼻咽部阻塞,创伤小,并发症少,手术疗效好。

  14. Study on the Machine of Neural Invasion of Adenoid Cystic Carcinoma%腺样囊性癌嗜神经侵袭机制的研究进展

    Institute of Scientific and Technical Information of China (English)

    郭峰; 吕春堂

    2004-01-01

    神经侵袭(neural invasion,NI),或神经周围侵袭(perineural invasion,PNI),即神经束膜内出现癌细胞浸润,是某些恶性肿瘤的一种扩散生长方式:腺样囊性癌(adenoid cystic carcinoma,ACC)有沿神经侵袭的特性。近年来人们发现,这一特性是影响该肿瘤患者复发和生存的重要预后因素,甚至

  15. Thomsen-Friedenreich (T) antigen as marker of myoepithelial and basal cells in the parotid gland, pleomorphic adenomas and adenoid cystic carcinomas. An immunohistological comparison between T and sialosyl-T antigens, alpha-smooth muscle actin and cytokeratin 14

    DEFF Research Database (Denmark)

    Therkildsen, M H; Mandel, U; Christensen, M;

    1995-01-01

    -known markers of normal MEC/basal cells (i.e. alpha-smooth muscle actin and cytokeratin 14) with T (Thomsen-Friedenreich) antigen and its sialylated derivative: sialosyl-T antigen,) in 17 normal parotid glands and in two tumour types with MEC participation (i.e pleomorphic adenomas (PA) and adenoid cystic...... carcinomas (ACC)) using immunohistology with well-defined monoclonal antibodies (MAbs). Paraffin-embedded/fresh frozen tissue sections were studied from 33/17 patients with PA and 15/7 patients with ACC. In normal parotid tissue coexpression of alpha-smooth muscle actin, cytokeratin 14, T and sialosyl...

  16. 趋化因子受体5在唾液腺腺样囊性癌中的表达及意义%CCR5 expression in adenoid cystic carcinoma of salivary glands

    Institute of Scientific and Technical Information of China (English)

    申志远; 孙沫逸; 张静; 杨向明; 刘利军; 李建虎; 梁亮; 杨永勤

    2013-01-01

    Objective To examine the expression of chemokine receptor( CCR5) in adenoid cystic carcinoma and its relationship with clinicopathologic types and neurotropism. Methods Immumohistochemical staining for CCR5 was performed in 32 primary adenoid cystic carcinoma and 35 normal salivary gland tissues. The relationship between staining intensity and clinicopathologic type and the peripheral nervous invasion was evaluated. Results The positive rate of CCR5 expression in adenoid cystic carcinoma was 93. 8% (30/32) , which was significantly higher than that in normal salivary glands. There was no significant difference in CCR5 expression among different clinicopathologic types. In the 30 CCR5 positive cases,the CCR5 expression was significantly different between nervous invasion cases and non-nervous invasion cases. Conclusion CCR5 may be associated with pathogenesis of adenoid cystic carcinoma and the invasion of the disease.%目的 探讨趋化因子受体5(CCR5)在唾液腺腺样囊性癌的表达及其与临床病理分型和嗜神经性的关系.方法 运用免疫组织化学的方法(SP法)检测CCR5在人唾液腺腺样囊性癌标本及正常唾液腺标本中的表达.结果 CCR5在唾液腺腺样囊性癌标本中的阳性表达率为93.8% (30/32),与在正常唾液腺组织的表达有显著性差异(P<0.05).CCR5在唾液腺腺样囊性癌不同的临床病理分型中的表达差异无统计学意义(P>0.05).在30例阳性表达的腺样囊性癌标本中,可见嗜神经现象组与未见嗜神经现象组中CCR5的表达有统计学差异(P<0.05).结论 CCR5可能与唾液腺腺样囊性癌的发生相关,其表达水平与腺样囊性癌的临床病理类型无相关性,与侵袭神经有相关性.

  17. 声反射鼻腔测量对儿童腺样体肥大的临床研究%Clinical research of acoustic rhinometry in children with adenoid hypertrophy

    Institute of Scientific and Technical Information of China (English)

    唐媛媛; 关庆捷; 刘迎曦; 付誉

    2014-01-01

    Objective To assess the clinical application of acoustic rhinometry (AR) in children with adenoid hypertro-phy.From the present study we would like to show that AR is a valid method to analyze nasal and nasopharyngeal volume of children suffering from adenoid hypertrophy in quantity .And then we can predict how the disorder of adenoid hypertrophy contributes to the growth of nose .Methods Thirty-five children with adenoid hypertrophy were examined with lateral X -ray and AR.Based on the adenoid /nasopharyngeal ( A/N) volume, all children were assigned to three groups:1) A/N≤0.60(total 8,boy 6,girl 2);2) 0.60.70(total 19,boy 13,girl 6).The parameters, including minimal cross -sectional area (MCSA), distance of the minimal cross -sectional area from the nos-tril (DMCA), nasal airway resistance (NR), nasal volume (NV), and nasopharyngeal volume (NPV), were achieved from the AR curve.Finally the above parameters were compared by the ANOVA .Results The characteristic feature of the AR curve in children with adenoid hypertrophy was flat in the posterior segment .In association with the degree of adenoid hypertrophy , NR increased gradually , while NV and NPV had a tendency to decrease .There was significant difference ob-served among the groups with respect to MCSA , DMCA, NR and NV.While comparison of NPV among the three groups showed a significant difference (P=0.000).Conclusion Acoustic rhinometry is a rapid, harmless, noninvasive method, and has a high reproducibility .Adenoid hypertrophy can affect the growth of the nose , which can be assessed by AR .Thus AR can be used to screen the children with OSAHS and provides information for individualized clinical treatment options .%目的:探讨声反射鼻腔测量对诊断儿童腺样体肥大的临床应用价值,对患儿的鼻腔、鼻咽腔容积等进行定量分析,探讨其鼻腔形态及通气情况,进而评价腺样体肥大对儿童鼻腔发育的影响。方法对35例腺样体肥大患儿行鼻

  18. 白三烯受体拮抗剂治疗儿童腺样体肥大临床研究%Clinical study on the leukotriene receptor antagonist in the treatment for adenoidal hypertrophy in children

    Institute of Scientific and Technical Information of China (English)

    朱美华; 王志坚; 温红艳; 粱敏

    2011-01-01

    目的 观察白三烯( LTs)受体拮抗剂(孟鲁司特钠)在儿童腺样体肥大(AH)治疗中的疗效,探讨LTs受体拮抗剂用于治疗儿童AH的临床可行性.方法 收集2007年1月至2010年12月在广州医学院第二附属医院就诊的上气道咳嗽综合征合并腺样体肥大和(或)并有过敏性鼻炎的患儿,分为观察组116例和对照组52例,各组均予对症治疗及按需使用抗生素,在此基础上观察组给予LTs受体拮抗剂(孟鲁司特钠)治疗16周.观察治疗前后各组患儿咳嗽持续天数、呼吸相关睡眠障碍症状指标评分及腺样体/鼻咽比值(A/N比值)的改变.结果 治疗16周后:(1)观察组呼吸相关睡眠障碍症状指标评分、咳嗽天数,A/N比值分别由(12.31 ±2.58)分、(52.59±11.87)d、0.77±0.04下降至(5.68±3.30)分、(19.99±11.14)d、0.64±0.07,治疗前后差异有统计学意义(P< 0.001).对照组治疗前后上述各指标差异无统计学意义(P>0.05).观察组与对照组在治疗前上述各指标差异无统计学意义,治疗后各指标间差异有统计学意义(P< 0.001);(2)对观察组中的上气道咳嗽综合征合并单纯AH及AH合并过敏性鼻炎(AH-AR)患儿进行统计学分析发现,两组上述各项指标治疗前差异无统计学意义,治疗后各指标间差异存在统计学意义(P< 0.001).结论 孟鲁司特钠治疗儿童上气道咳嗽综合征,能减少咳嗽持续的天数,并不同程度改善各类型AH的临床症状及缩小腺样体体积,且对单纯AH疗效优于AH-AR患儿.%Objective To study the clinical feasibility of therapy with leukotriene receptor antagonist, montelukast for adenoidal hypertrophy in children. Methods Children with upper respiratory cough syndrome complicated with adenoidal hypertrophy and/or allergic rhinitis were selected for the present study. The study population was divided into 2 groups: experiment group and control group. Symptomatic therapy together with antibiotics, if needed

  19. Fatty Acid Binding Protein 7 Is a Molecular Marker in Adenoid Cystic Carcinoma of the Salivary Glands: Implications for Clinical Significance

    Directory of Open Access Journals (Sweden)

    Janyaporn Phuchareon

    2014-12-01

    Full Text Available Adenoid cystic carcinoma (ACC is an aggressive malignant neoplasm of the salivary glands. Its diagnosis is difficult due to overlapping features with other salivary tumors. Gene expression analysis may complement traditional diagnostic methods. We searched gene expression patterns in the Gene Expression Omnibus (GEO database and in our tumor and normal samples. The biologic and prognostic potential of the identified genes was analyzed. The GEO data set of primary xenografted ACCs revealed that expression of five genes, engrailed homeobox 1 (EN1, fatty acid binding protein 7 (FABP7, hemoglobin epsilon 1, MYB, and versican (VCAN, was dramatically increased. mRNA expression of EN1, FABP7, MYB, and VCAN distinguished our sporadic ACCs from normal tissues and benign tumors. FABP7 expression appeared to be regulated differently from EN1 and MYB and was crossly correlated with poor prognosis in our ACC cohort. Immunohistochemistry showed that FABP7 protein was predominantly expressed in the nucleus of myoepithelial cells of both tubular and cribriform subtypes. In contrast, in the solid subtype, which is often associated with a lower survival rate, FABP7 protein was uniformly expressed in cancerous cells. One case with cribriform architecture and the highest level of FABP7 mRNA showed strong FABP7 staining in both duct-type epithelial and myoepithelial cells, suggesting that diffuse expression of FABP7 protein might be related to aggressive tumor behavior and poor prognosis. We propose FABP7 as a novel biomarker in ACC. The molecule may be useful in diagnosis and for identifying more effective therapies targeting this protein or upstream molecules that regulate it.

  20. c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands

    Directory of Open Access Journals (Sweden)

    Janyaporn Phuchareon

    2014-10-01

    Full Text Available Adenoid cystic carcinoma (ACC is an aggressive malignant neoplasm of the salivary glands in which c-Kit is overexpressed and activated, although the mechanism for this is as yet unclear. We analyzed 27 sporadic ACC tumor specimens to examine the biologic and clinical significance of c-Kit activation. Mutational analysis revealed expression of wild-type c-Kit in all, eliminating gene mutation as a cause of activation. Because stem cell factor (SCF is c-Kit's sole ligand, we analyzed its expression in the tumor cells and their environment. Immunohistochemistry revealed its presence in c-Kit–positive tumor cells, suggesting an activation of autocrine signaling. We observed a significant induction of ERK1/2 in the cells. SCF staining was also found in other types of non-cancerous cells adjacent to tumors within salivary glands, including stromal fibroblasts, neutrophils, peripheral nerve, skeletal muscle, vascular endothelial cells, mucous acinar cells, and intercalated ducts. Quantitative PCR showed that the top quartile of c-Kit mRNA expression distinguished ACCs from normal salivary tissues and was cross-correlated with short-term poor prognosis. Expression levels of SCF and c-Kit were highly correlated in the cases with perineural invasion. These observations suggest that c-Kit is potentially activated by receptor dimerization upon stimulation by SCF in ACC, and that the highest quartile of c-Kit mRNA expression could be a predictor of poor prognosis. Our findings may support an avenue for c-Kit-targeted therapy to improve disease control in ACC patients harboring the top quartile of c-Kit mRNA expression.

  1. 低温等离子腺样体射频消融术治疗儿童腺样体肥大的研究%Study of low-temperature plasma radiofrequency ablation for treatingthe children with adenoid hypertrophy

    Institute of Scientific and Technical Information of China (English)

    邢海涛; 李玉梅; 王侠

    2012-01-01

    [Objective] To investigate the clinical efficacy of nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation for treating the children with adenoid hypertrophy.[Methods] Seventy patients with adenoid hypertrophy were divided by random digits table method into treatment group and control group with 35 cases each.The patients in control group underwent traditional by-mouth adenoidectomy,while the patients in treatment group were treated with nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation.The operative time and intraoperative blood loss in two groups were calculated.The children were followed up for 6-12 months and the clinical efficacy of snoring,nasal obstruction and hearing and the postoperative complications were observed.[Results]The intrsoperative blood loss in treatment group was significantly lower than that in control group[(2.23±0.74)ml vs.(24.58±8.19)ml](t=19.733,P < 0.01).The total efficiency of snoring,nasal obstruction and hearing in treatment group was 91.4%(32/35),82.9%(29/35)and 77.1%(27/35),respectively,and which was significantly higher than that in control group[68.6%(24/35),62.9%(22/35)and 57.1%(20/35)](x2 =5.354,5.293,5.421,P<0.01).There,was no residual adenoid and adenoidal hypertrophy recurrence in treatment group,while the postoperative residual adenoid rate in control group was 91.4%(32/35),the adenoidal hypertrophy recurrence rate was 20.0%(7/35).There was significant difference in postoperative complication incidence between two groups(x2 =9.391,P < 0.01).[Conclusions] Nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation for treating the children with adenoid hypertrophy has better clinical efficacy,less intraoperative blood loss,no postoperative residual and other complications.It is an ideal method for treating the children with adenoid hypertrophy and worthy of clinical application.%目的 探讨鼻内镜辅助经口低温等

  2. 儿童反复发作型中耳炎与腺样体肥大的相关性研究%The correlation sstudies between recurrent otitis media and adenoid hypertrophy in children

    Institute of Scientific and Technical Information of China (English)

    刘卫卫; 张淑君; 张宇丽; 岳卓立; 尹桂茹

    2013-01-01

    目的:探讨腺样体免疫状况与分泌性中耳炎(SOM)的相关性.方法:采用免疫组织化学SP法检测30例反复发作SOM、17例非反复发作SOM及20例单纯腺样体肥大(无中耳炎病史)患儿腺样体组织中PCNA、BCL-2,CD4+、C D8+的表达及CD4+/CD8+的值.结果:反复发作SOM组PCNA、BCL-2、CD4+、CD8+表达阳性细胞数及CD4+/CD8+分别为30.85±1.73、21.27±1.25、41.90±9.07、20.45±7.08、2.10±0.17,显著高于非反复发作组(25.50±1.66、14.23±1.06、17.40±6.85、13.02±5.88、1.33±0.11,均P<0.01)及单纯腺样体肥大组(25.25±1.75、14.05±1.02、16.30±8.21、11.15±5.71、0.39±0.15,均P<0.01);后2组间各指标比较均差异无统计学意义(均P>0.05).性别及腺样体大小3组间差异无统计学意义(P>0.05).单纯腺样体肥大组中>6~10岁、>10~14岁与3~6岁PCNA比较差异有统计学意义(P<0.05).结论:反复发作的SOM患儿腺样体中T淋巴细胞亚群活性增高,处于增殖期细胞增多,致使腺样体增生肥大,同时局部免疫增强,加重了SOM.年龄及性别与SOM的发生无关,但低龄是腺样体肥大的影响因素.反复发作的SOM患儿伴腺样体肥大时,应尽早行腺样体切除术.%Objective:To investigate the relationship between the immune status of adenoids and secretory otitis media(SOM).Method:The adenoids tissue samples of 30 cases of recurrent secretory otitis media(SOM),17 cases of non-recurrent secretory otitis media and 20 cases of the adenoids hypertrophy without SOM were studied by immunohistochemical method.Result:The expression of PCNA,BCL-2,CD4 +,CD8 + cells and CD4 +/CD8 + in recurrent SOM tissue were 30.85±1.73,21.27±1.25,41.90±9.07;20.45±7.08 and 2.10±0.17,respectively,which was remarkably higher than those of non-recurrent SOM,(25.50 ± 1.66,14.23 ± 1.06,17.40 ± 6.85,13.02±5.88,1.33 ±0.11,respectively) and those of simple adenoid hypertrophy(25.25 ± 1.75,14.05 ± 1.02,16.30±8.21,11.15±5.71 and 1.39

  3. Comparative study on dynamical system cutterbar via nasal endoscope for adenoidectomy and rout curettage of adenoids%鼻内镜下动力系统切割器行腺样体切除术与常规腺样体刮除术的疗效比较研究

    Institute of Scientific and Technical Information of China (English)

    黄映红; 张建国; 黄敏齐; 严小玲; 翟锦明; 马钊恩

    2009-01-01

    目的 比较鼻内镜下经口动力系统切割器行腺样体切除术与常规腺样体刮除术的疗效.方法 腺样体肥大患儿136例,其中69例接受鼻内镜下动力系统切割器行腺样体切除术,67例接受常规腺样体刮除术,比较两种术式的疗效.结果 常规腺样体刮除术治疗组中有5例存在腺样体残留,有2例存在并发症(出血及咽鼓管咽口损伤),而鼻内镜下动力系统切割器行腺样体切除术无1例腺样体残留及并发症.结论 鼻内镜下动力系统切割器经口腺样体切除术是治疗腺样体肥大的最好手术方式.%Objective The aim of this study was to compare the effectiveness of dynamical system cutterbar via nasal endoscope for adenoidectomy by mouth and rout curet-tage of adenoids. Methods 136 cases with adenoid hypertrophy, 69 cases underwent dynamical system cutterbar via nasal endoscope for adenoidectomy by mouth while 67 cases were performed by rout curettage of adenoids. Then compared the curative effect with two groups. Results 8 cases had adenoid residual ,3 cases had complication(bleeding or the impairment of ostium tubae anditive) in the rout curettage of adenoids group. No adenoid residual or other complication had been noted in dynamical system cutterbar via nasal endoscope for adenoidectomy by mouth group. Conclusion Dynamical system cutterbar via nasal endoscope for adenoidectomy by mouth is the best way to cure adenoid hypertrophy in present time.

  4. Analysis of Adenoid Vegetation Children with Different Types of Tympanograms and Secretory Otitis Media%腺样体肥大患儿鼓室导抗图与分泌性中耳炎的关系探讨

    Institute of Scientific and Technical Information of China (English)

    高永平; 田从哲; 刘会清; 孟胜环; 刘海燕

    2013-01-01

    目的:探讨腺样体肥大患儿的不同鼓室导抗图与分泌性中耳炎的关系。方法回顾性分析2009年1月~2011年6月收治的328例腺样体肥大患儿的临床资料,分析统计分泌性中耳炎的发病例(耳)数及声导抗测试诊断分泌性中耳炎的阳性率。结果328例腺样体肥大患儿中有104例(169耳)最终经鼓膜穿刺或鼓膜置管确诊为分泌性中耳炎(31.71%,104/328),其中鼓室导抗图为B型者89例152耳,最终确诊为分泌性中耳炎者为86例147耳,阳性率为96.71%(147/152);鼓室导抗图为C型(负压在-150 daPa以上)者33例49耳,最终确诊为分泌性中耳炎者为16例20耳,阳性率为40.82%(20/49);鼓室导抗图为A s型者2例2耳最终均确诊为分泌性中耳炎。结论腺样体肥大患儿无论有无听力下降主诉,均应行声导抗测试,B型鼓室导抗图对鼓室积液判断的准确率最高,C型次之,As型也有鼓室积液的可能。%Objective To explore the relationship between adenoid vegetation children with different types of tympanograms and secretory otitis media in children and diagnosis of secretory otitis media .Methods A retrospec-tive study was carried out among 328 cases with adenoid vegetation in children ,including simple adenoid vegetation and associated with chronic tonsillitis and tonsillar hypertrophy ,from August 2010 to May 2012 .The incidence of secretory otitis media and outcomes of tympanometry for the diagnosis were analyzed .Results 104 cases were diag-nosed with secretory otitis media by tympanic membrane puncture or tympanostomy tube in 328 cases with adenoid vegetation (32 .31% );86 cases (147 ears) were finally diagnosed as secretory otitis media among 89 cases (152 ears) with type B tympanogram (147/152 ,96 .63% );16 cases (20 ears) were finally diagnosed secretory otitis media among 33 cases (49 ears) with type C tympanogram (20/49 ,40 .82% );2 cases (2 ears) with

  5. 腺样体肥大对儿童听力的影响%The pathological effect of adenoid hypertrophy on auditory function of children with such a condition

    Institute of Scientific and Technical Information of China (English)

    季超; 高刚; 钱茂华

    2011-01-01

    Objective To investigate the pathological effect of adenoid hypertrophy on auditory function of children with this kind of lesion and the rehabilitation effect of surgical therapy on their hearing level based on a clinical trial. Methods Included in this retrospective study were 140 children cases with adenoid hypertrophy, treated by adenoidectomy and grommet insertion. Auditory function of these children was tested by pure tone audiometry and tympanometry before the operation and one week after fee surgery respectively. Then, careful analysis was done on these data to evaluate the effects of adenoid hypertrophy and relative therapies on auditory function of these children. Results Among these children, 93 cases complained hearing decrease, with 20 (21.51%) showing sensorineural hearing loss at various levels in its nature as seen from audiometry. In this part of cases, tympanometry showed that 88 (165 ears) were B type of tympanogram and 5 (9 ears) were C type of this kind of curve figure. In the other part of children (47 cases) complaining no obvious feeling of auditory acuity decreasing, 25 (53.19%) were seen with hearing loss in one or both ears at various levels and in different nature as revealed from pure tone audiometry, with 30 cases (63.83%) having an abnormal tympanogram, among whom 22 showed a B type of tympanogram 8 showed a C type of curve figure. After adenoid surgery and grommet insertion, all these children were seen with their hearing improved obviously, with very significant statistical significance when compared with those data obtained preoperatively. Conclusions Adenoid hypertrophy usually cause conductive hearing loss in children, but may show sensorineural hearing loss at various levels in its nature in a part of cases. The therapy combined adenoidectomy with grommet insertion can recover their hearing effectively.%目的 观察腺样体肥大对儿童听力的影响及手术后儿童听力的恢复情况.方法 回顾性研究手术

  6. 腺样体、扁桃体肥大患儿肺功能的改变及手术对其影响%Pulmonary function in children with adenoid and tonsil hypertrophy

    Institute of Scientific and Technical Information of China (English)

    庞冲; 刘传合; 谷庆隆; 李硕; 黄春雷; 高帆; 陆颖霞

    2012-01-01

    Objective Explore the pulmonary function in children with adenoid and tonsil hypertrophy and it changes by operation . Method 130 children with adenoid and tonsil hypertrophy were enrolled in the study. MS-IOS pulmonary function testing was performed preoperatively for each patient, and repeated postoperatively for 50 patients with abnormalities in preoperative one. Respiratory impedance ( Zr), resonance frequency (Rf), viscous resistance of R5, R20, X5, X35 elastic resistance, central airway resistance (Re), peripheral airway resistance (Rp) and other parameters were evaluated. The influence of different hypertrophic degree of adenoid and tonsil, and of operative intervention were also inverstigated. Results Adenoid and tonsil hypertrophy resulted in a significant high value in Z5, R5, R20, X5, Re and Rp, However, hypertropic degrees showed unclear affection ( P > 0.05 ). Surgical intervention presented an obviously improvement in Z5, R5 and R20 ( P < 0.05 ). Conclusion Airway obstruction existed in children with adenoid and tonsil hypertrophy was reduced by adenoidectomy and tonsillectomy. Early surgical intervention is necessary in order to eliminate the impairment on ventilation function in these children.%目的 探讨腺样体、扁桃体肥大患儿肺功能的改变及手术对其影响.方法 选择因腺样体,扁桃体肥大住院手术患儿130例,采用MS-IOS肺功能仪检测其肺功能,并对术前肺功能异常的50例患儿术后随诊并再次行肺功能检测.采用呼吸阻抗(Zr)、共振频率(Rf),黏性阻力R5、R20,弹性阻力X5、X35,中心气道阻力(Rc)、外周气道阻力(Rp)等参数,分析不同程度腺样体、扁桃体肥大患儿以上参数的改变及手术前后的差异.结果 腺样体、扁桃体肥大患儿多数存在气道阻塞,Z5、R5、R20、X5、Rc、Rp等值偏高;但不同程度腺样体、扁桃体肥大患儿肺功能水平未见统计学差异(P>0.05);与术前比较,患儿手术

  7. Clinical symptoms of obstructive sleep apnea syndrome in children caused by adenoidal hyper-trophy%儿童腺样体肥大引发睡眠呼吸暂停综合征临床症状分析

    Institute of Scientific and Technical Information of China (English)

    孙瑶; 常远; 卢烨; 孙书臣

    2014-01-01

    Objective To discuss the clinical symptoms of obstructive sleep apnea hypopnea syndrome(OSAHS)in children caused by adenoidal hypertrophy.Methods The questionnaires,fibrous endoscopic examination and sleep breathing studies were performed in 44 children with adenoidal hypertrophy.Results Polysomnography(PSG)was gived to 16 cases who was proved with OSAHS.By the analysis of questionnaires,the main clinical manifestations of the children with OSAHS is sno-ring(100%)、sleep apnea(87.5%)、mouth breathing(81.2%)、disturbed nocturnal sleep(81.2%)and nasal congestion(50%). Conclusion Childrens OSAHS caused by adenoidal hypertrophy could be detected by analyzing the related clinical symptoms.%目的探讨儿童腺样体肥大引发睡眠呼吸暂停综合征(Obstructive Sleep Apnea Hypopnea Syndrome, OSAHS)的临床症状。方法对门诊44例腺样体肥大儿童进行问卷调查、纤维鼻咽镜检查及多导睡眠监测(polysom-nography,PSG),以PSG监测结果作为诊断OSAHS的标准,对腺样体肥大引发OSAHS患儿的临床症状进行分析。结果44例患儿中有16例诊断为OSAHS,其主要症状按出现比例依次为睡眠打鼾(100%)、呼吸暂停(87.5%)、张口呼吸(81.2%)、睡眠不安(81.2%)、鼻塞(50%)等。结论通过对儿童腺样体肥大引发OSAHS的临床症状分析,有助于对此类患儿从症状上做出早期诊断。

  8. p16 Gene Expression in Salivary Gland Adenoid Cystic Carcinoma%抑癌基因P16在涎腺腺样囊性癌中的表达意义

    Institute of Scientific and Technical Information of China (English)

    郑雄伟; 许磊; 陈刚

    2001-01-01

    [目的]探讨抑癌基因p16与涎腺腺样囊性癌的发生发展的关系。[方法]采用免疫组织化学法检测30例腺样囊性癌中p16基因表达情况。[结果]腺样囊性癌组织中阳性表达率为76 6%,p16蛋白阳性率在腺样囊性癌的腺样型、管状型、混合型、实体型中分别为90%、100%、75%、42.9%,显示p16蛋白表达阳性率随恶性程度的上升而降低,p16阳性与阴性之间的5年生存率则无明显差异。[结论]抑癌基因p16的表达与肿瘤的病理类型有关,而腺样囊性癌预后好于其它肿瘤可能与其p16缺失少有关。%[ Purpose ] To explore the relationship between gene p 16 and genesis as well as development of adenoid cystic carcinoma. [ Method ]The SP immunohistochemieal method was used .The expressions of p16 gene protein in 30 cases of salivary gland adenoid cystic carcinoma (SGACC) were studied. [ Results]The positive expression for p 16 gene protein was 76.6%. The positive rates of p 16 gene in SGACC classic cribriform, tubular, mixed and solid patterns were 90%, 100%, 75%and 42.9% respoctively.The positive rate of p16 gene protein expression markedly reduced with the in crease of pathologic grade.There was no significant difference between p16 positive and p16 negative expression cases in 5-year survival.[Conclusion]The expression of suppressor gene p16 relates to pathologic types of tumor.The prognosis of adenoid cystic carcinoma is better than those of other tumors. It may be correlated with the loss of p16 gene protein.

  9. Treatment of Adenoid Hypertrophy in Children by Plasma Ablation Combined With Surgical Resection%等离子消融合并手术切除治疗儿童腺样体肥大

    Institute of Scientific and Technical Information of China (English)

    卢新丰; 张国顺; 郭自奇; 黄晓阳

    2015-01-01

    Objective To investigate the clinical effect of plasma ablation combined with surgical resection for the hypertrophy of adenoid hypertrophy in children. Methods In our hospital, 140 cases of adenoid hypertrophy children were randomly divided into observation group and control group, 70 cases in each group. Two groups of patients were treated by surgical treatment, on this basis, the observation group combined with plasma ablation treatment. Results In the observation group treatment effective rate was 91.43%, LSaO2 for (91.76±4.59)%, AHI (7.78±2.56) times / h; the control group treatment effective rate is 78.57%, lsao2 for (81.28±4.47)%, AHI (16.54±3.66) times / h. The indexes of the observation group were significantly better than those of the control group (P<0.05). Conclusion The clinical effect of plasma ablation combined with surgical resection for adenoid hypertrophy in children is remarkable, and the improvement of the indexes is obvious.%目的:分析并探讨等离子消融合并手术切除治疗儿童腺样体肥大的临床效果。方法选取在我院接受治疗的腺样体肥大儿童140例,将其随机分为观察组与对照组,每组70例。两组患者均采用手术治疗,在此基础上,观察组联合等离子消融治疗。结果观察组治疗有效率为91.43%,LSaO2为(91.76±4.59)%,AHI 为(7.78±2.56)次/h ;对照组治疗有效率为78.57%,LSaO2为(81.28±4.47)%,AHI 为(16.54±3.66)次/h。观察组各项指标均明显优于对照组(P <0.05)。结论等离子消融合并手术切除治疗儿童腺样体肥大临床效果显著,且各项指标改善明显。

  10. 鼻内镜下两种不同手术方式切除腺样体的比较%A comparison of temperature-controlled radiofrequency and powered microdebrider in resection of adenoid hypertrophy

    Institute of Scientific and Technical Information of China (English)

    赵新; 肖大江; 袁渊; 朱国臣; 张永胜

    2012-01-01

    Objective To compare the clinical outcomes of temperature-controlled radiofrequency and powered microdebrider in the surgical treatment of adenoid hypertrophy. Methods A total of 78 cases with adenoid hypertrophy underwent adenoidectomy was equally divided into two groups of A (surgery with temperature-controlled radiofrequency) and B(surgery with powered microdebrider). The operative time, blood lose, complications and effectiveness rate were compared between two groups. Results The surgeries were performed smoothly without any severe complications in both groups. The operative time was shorter and blood lose was less in group A than those in group B[(18. 3±2.4) min vs. (37. 9±5. 5) min and (9. 4±3.1) ml vs. (61. 4±7. 8) ml] (P<0.05). Conclusion Compared to powered microdebrider. surgical resection of adenoid hypertrophy with temperature-controlled radiofrequency is with shorter operative time and less blood lose.%目的 比较鼻内镜下分别使用低温等离子系统和电动切割器切除腺样体的优越性.方法 腺样体切除手术的患儿78例均分为两组:A组使用低温等离子手术系统;B组使用电动切割器.比较两组的手术时间、术中出血量、术后并发症及有效率.结果 两组患儿手术顺利,术后效果好,无严重并发症发生.A组手术时间较B缩短[(18.3±2.4) min vs.(37.9±5.5)min] (P<0.05);A组出血量较B组减少[(9.4±3.1) ml vs.(61.4±7.8)ml](P<0.05).结论 与应用电动切割器比较,使用低温等离子手术系统实施腺样体切除术具有手术时间短、出血少的优势.

  11. Causes of secretory otitis media in infants without adenoid hypertrophy%不伴腺样体肥大婴幼儿分泌性中耳炎的病因分析

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

      目的探讨不伴腺样体肥大婴幼儿分泌性中耳炎的发病原因。方法回顾分析2000-2012年解放军总医院耳鼻喉头颈外科住院收治23例(36耳)6岁婴幼儿分泌性中耳炎(排除腺样体肥大)的临床资料。结果23例(36耳)中伴有鼻窦炎者6例(26.1%),5例发病前有急性上感病史(21.7%),伴有乳突气化不良者3例(13.0%),伴有外耳、中耳畸形者3例(13.0%),伴原发性纤毛运动障碍1例(4.3%),5例未发现明显解剖结构异常或相关病灶存在。5例患儿分泌性中耳炎发作≥2次。结论婴幼儿分泌性中耳炎常见病因为腺样体肥大、上呼吸道感染、鼻窦炎,原发性纤毛运动障碍值得注意。%Objective To study the causes of secretory otitis media (SOM) in infants without adenoid hypertrophy. Methods Clinical data about 23 infants (36 ears) with SOM (adenoid hypertrophy was excluded) admitted to our department from 2000 to 2012 were retrospectively analyzed. Results Of the 23 infants, 6 (26.1%) were diagnosed with nasal sinusitis, 5 (21.7%) were found with a history of acute upper respiratory tract infection before SOM, 3 (13.0%) were diagnosed with bad mastoid pneumatization and congenital malformation of the external and middle ear, 1 (4.3%) with primary ciliary dyskinesia, 5 (21.7%) were found to have no clear abnormal structure and other lesions, and 5 (21.7%) were diagnosed with recurrent SOM. Conclusion The common causes of SOM in infants are adenoid hypertrophy, acute upper respiratory tract infection, nasal sinusitis and primary ciliary dyskinesia.

  12. Clear Lung Fights Soup Treatment Curative Effect Observation of Children with Adenoid Hypertrophy%清肺散结汤治疗小儿腺样体肥大的疗效探讨

    Institute of Scientific and Technical Information of China (English)

    王艳玲

    2015-01-01

    Objective To explore the clear lung fights soup clinical curative effect for the treatment of infantile adenoid hypertro-phy. Methods Select our hospital of 60 cases of children with adenoid hypertrophy were randomly divided into control group (30 patients receiving treatment: rhinitis tablet) and observation group (30 cases, treated with clear lung fights soup) in the two groups, to compare the treatment effect in two groups of children. Results The observation group and control group total effective rate was 93.3%and 93.3%respectively, in patients with significant difference between groups(P<0.05);After treatment, the clinical symp-toms and adenoidectomy volume integral, the observation group was significantly lower than(P<0.05).Conclusion Clear lung fights soup cure infantile adenoid hypertrophy curative effect, clinical symptoms improved significantly.%目的:探讨清肺散结汤治疗小儿腺样体肥大的临床疗效。方法随机选择该院收治的60例腺样体肥大患儿,随机分为对照组(30例,接受通窍鼻炎片治疗)和观察组(30例,接受清肺散结汤治疗),比较两组患儿治疗效果。结果观察组和对照组患者总有效率分别为93.3%和70.0%,组间差异有统计学意义(P<0.05);治疗后,在临床症状积分和腺样体体积积分方面,观察组显著低于(P<0.05)。结论清肺散结汤治疗小儿腺样体肥大的疗效确切,患儿临床症状改善明显。

  13. Carcinoma adenoescamoso do colo uterino mimetizando carcinoma adenóide basal: relato de um caso e revisão da literatura Adenosquamous carcinoma of the cervix mimicking adenoid basal carcinoma: case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Álvaro Piazzeta Pinto

    2007-02-01

    tumor that contains a mixture of malignant cells with squamous and glandular differentiation. The literature points to the importance of making this diagnosis when the cellular components are still well differentiated in the sample, otherwise the tumor may be erroneously interpreted as squamous carcinoma or adenocarcinoma. This study describes an unusual presentation of a adenosquamous carcinoma in a 47 year old patient. After conflicting cytological diagnoses and a history of abnormal uterine bleeding caused by cervical endometriosis, the patient was subjected to radical hysterectomy and a final diagnosis was obtained. The tumor was diagnosed as adenosquamous carcinoma. In many aspects, however, it was similar to the adenoid basal carcinoma. Characteristic features of the adenoid basal carcinoma such as the presence of high-grade squamous intraepithelial lesion in the surface epithelium, squamous and glandular differentiation in the center of the neoplastic mass, and basaloid cells in deep areas of the tumor were observed. Therefore, the following elements usually absent from adenoid basal carcinoma were present in this case: atypia and mitotic figures in undifferentiated cells, squamous-mucinous intraepithelial lesion (SMILE in the superficial areas. Epidemiological and clinical data, such as patient age (47, race (white and presentation (a cervical mass, concurred to exclude the diagnosis of adenoid basal carcinoma. Other differential diagnoses include pure squamous carcinoma or adenocarcinoma, collision tumor, and endometrial adenocarcinoma with squamous differentiation invading the uterine cervix.

  14. Application of low-dose 16-slice spiral CT scanning technology in adenoidal hypertrophy in children%16层螺旋CT低剂量扫描技术在儿童腺样体肥大中的应用

    Institute of Scientific and Technical Information of China (English)

    党保华; 曲金荣; 张建伟; 刘翠翠; 黎海亮

    2012-01-01

    目的:探讨16层螺旋CT低剂量扫描技术在儿童腺样体肥大的临床应用.方法:对46例临床疑似腺样体肥大儿童行16层螺旋CT低剂量和常规剂量扫描,将其随机分为两组,时比两种剂量扫描的图像质量与患者的辐射剂量.结果:16层螺旋CT低剂量扫描与常规剂量扫描对显示鼻咽部的解剖结构及病变差异无显著性意义(P=0.381).对低剂量组/常规剂量组两组腺样体CT值平均值之间无统计学差异(P=0.256).CT值标准偏差之间无统计学差异(P=0.313).低剂量CT扫描显示儿童鼻咽部扫描参数中CTDIvol为4.35 mGy、DLP为40.62 mGy·cm,常规剂量CTDIvol为8.65 mGy、DLP为81.23 mGy·cm.低剂量与常规剂量相比,其CTDIvol和DLP降低了约50%的辐射剂量.结论:16层螺旋CT低剂量扫描对腺样体肥大的诊断结果与常规剂量均相同,故16层螺旋CT低剂量扫描临床疑似腺样体肥大的患者,完全能替代常规剂量的16层螺旋CT扫描.%Objective:To investigate clinical application value of low-dose 16-slice spiral CT scanning technology in the adenoidal hypertrophy of children. MethodS:46 cases of children with adenoidal hypertrophy underwent low-dose (group A) and conventional-dose (group B) 16-slice spiral CT scanning. The image quality and radiation dose in two groups were compared. Results: The display of the anatomical structure of the nasopharynx and adenoidal hypertrophy showed no significant difference between low-dose CT scanning and conventional-dose CT scanning (P = 0. 381). It showed no significant difference in the mean of CT values (P=0. 256) and the standard deviation of CT values (P=0. 313) between low-dose and conventional-dose scanning. The CTDIvol of low-dose CT scanning was 4. 35mGy,and DLP was40. 62mGy ·cm,and the CTDIvol of conventional doses was 8. 65mGy,DLP was 81. 23mGy-cm. The CTDIvol and DLP of low-dose CT scanning decreased about 50% as compared with those of conventional dose scanning. Conclusion

  15. 鼻内镜下吸切器治疗小儿腺样体肥大的疗效观察%Observation on the Efficacy of Nasal Endoscopy-assisted Treatment of Adenoidal Hypertrophy in Children

    Institute of Scientific and Technical Information of China (English)

    邵鑫; 张维天; 吴涛; 陈瑶

    2012-01-01

    Objective To discuss the efficacy and safety of nasal endoscopy-assisted treatment of adenoidal hypertrophy in children. Methods 63 patients aged 4 to 12 years old, diagnosed with adenoidal hypertrophy in children were treated by nasal endoscopy-assisted sucking and cutting. All cases' nasopharyngeal cavity diameters were greater than or equal to 0.71. Fiber endoscope checking the nostril degree after adenoid obstruction: Ⅲ°52 cases, Ⅳ°11 cases. Among these cases,nasal obstruction,rhinorrhea were first diagnosed in 15 cases. Sleep snoring,mouth breathing,breath occurred in 39 cases and hearing loss in 9 cases. 11 patients with Ⅲ° hypertrophy of the tonsils, their tonsil were removed. At the same time,3 patients with middle ear effusion were operated by grommet insertion. Results 9 patients with secretory otitis media review of a-coustic immittance tympanometry function curves were type A, their speech frequency hearing recovered to premorbid levels. 12 patients' nasal ventilation were in normal status,3 cases were improved significantly. Sleep snoring and mouth breathing symptoms disappeared in 37 cases, 2 cases were improved. All patients had no symptoms such as postoperative bleeding,nasopharyngeal adherence or injury. Conclusion Operation is a good method to treat clinical symptoms of adenoidal hypertrophy. Compared with the traditional method,nasal endoscopy-assisted adenoidectomy resection has many advantages such as clear vision, small wound,less bleeding,rare residue,good treatment effect and so on,which can be promoted.%目的 探讨鼻内镜下吸切器治疗小儿腺样体肥大的疗效和安全性.方法 对63例4 ~12岁腺样体肥大的患儿行鼻内镜下吸切器吸切治疗,所有病例鼻咽侧位片示腺样体厚度/鼻咽腔前后径≥0.71,纤维鼻咽镜检查腺样体阻塞后鼻孔的程度Ⅲ°52例;Ⅳ°11例.其中以鼻塞、流涕首诊15例,睡眠打鼾、憋气、张口呼吸39例,听力下降9例.11例并发扁桃

  16. 小儿腺样体肥大的螺旋CT仿真内窥镜(CTVE)成像技术探讨%Discussion about CT Virtual Endoscopy(CTVE) Imaging Technology of Pediatric Adenoidal Hypertrophy

    Institute of Scientific and Technical Information of China (English)

    栾海; 王春生; 李宏伟

    2011-01-01

    Objective To investigate how to make the inspecting technology better to further improve the adenoids hypertrophy patients' 3D image quality. Methods CTVE technology was used to conduct an examination toward 32 cases of adenoid hypertrophy. The scanning parameters were adjusted properly, then after controlling the imaging direction, the 3D images of the nasopharynx were formed in the virtual NE's front and rear position. The result of CT inspection were calculated and compared with that of CTVE technology or NE. Results All the adenoid hypertrophy patients were inspected by CTVE in this group. The statistical consistent analysis was performed about the posterior naris obstruction's extent inspected by CTVE at the front position and NE respectively, withχ2 value of 4.000, P value of 0.261 (>0.05) by Mateχ2 Test, and the value of 0.806(>0.75) by Consistency Test kappa. Two groups of the statistics had a good consistency, and the diagnosis with various methods had no significant difference. Conclusion When inspecting the adenoidal hypertrophy patients by CTVE, the scanning parameters have to be adjusted properly, and the image direction has to be controlled, then the 3D reconstruction image can be achieved, which plays an important role in clinic.%目的:探讨如何改进螺旋CT仿真内窥镜检查技术,以提高腺样体肥大患者三维成像质量.方法:利用螺旋CT仿真内窥镜技术对32例腺样体肥大患者进行检查,合理调整扫描参数、控制成像方向,形成三维鼻咽前视位及后视位仿真内镜影像,将螺旋CT检查情况与术中或鼻内窥镜结果进行统计比较.结果:本组腺样体肥大患者全部完成CTVE检查,CTVE前视位与NE检查后鼻孔阻塞程度结果进行统计学一致性分析,配对卡方x2=4.000,P=0.261(>0.05),Kappa检验值为0.806(>0.75).提示2组数据一致性较好,诊断方法无显著性差异.结论:利用螺旋CT仿真内窥镜技术对腺样体肥大患者检查时合理调整

  17. Behavior research of allergic rhinitis with adenoid hypertrophy in children%变应性鼻炎伴腺样体肥大儿童行为调查研究

    Institute of Scientific and Technical Information of China (English)

    敬云龙; 胡彬雅; 黄晶; 赵斯君; 陶礼华; 彭湘粤

    2012-01-01

    目的:探讨变应性鼻炎伴腺样体肥大患儿手术治疗对其行为方面的影响.方法:117例变应性鼻炎伴腺样体肥大患儿随机分成研究组和对照组,其中对照组42例,局部使用类固醇喷鼻剂,连续使用2~3个月,同时给予口服抗组胺药治疗;研究组75例,给予内镜下腺样体切除术,同时使用药物治疗,治疗方法同对照组.3个月后对所有患儿进行行为调查比较,内容包括睡眠、性格、记忆等方面.结果:治疗前两组患儿在腺样体肥大、鼻部症状以及临床问卷分值方面无显著差异,具有可比性.研究组经治疗后在“响鼾”、“不安宁的睡眠或频繁醒觉”、“鼻阻塞而张口呼吸”以及“频繁的上呼吸道感染”4个症状较对照组的改善差异有统计学意义(P<0.05).结论:变应性鼻炎伴腺样体肥大患儿宜采用手术治疗,腺样体切除利于行为症状的改善.%Objective;To investigate the behavior difference of allergic rhinitis with adenoid hypertrophy between study group and control group. Method: One hundred and seventeen children diagnosed as allergic rhinitis with adenoid hypertrophy were enrolled in our study were divided into study group and control group. Forty-two children treated with local steroid nasal spray for two to three months and antihistamine were control group. Seventy-five children treated with endoscopic adenoidectomy and drug treatment were study group; All children' parents were inquired for their clinical presentation. Result; No distinctive differences were found between the two groups(P>0. 05 Jin adenoid hypertrophy, accompanying nasal problems and clinical questionnaire scoring. Significant sratistical distinction were found(P<0. 05)in snoring, sleep disturbance and frequent arousal, nasal obstructive moth-breathing, and recurrent respiratory tract infection between the two groups after three-month follow up. Conclusion: Endoscopic adenoidectomy should be taken into

  18. Reasons of postoperative recurrence After Resection of OSAHS in Children Adenoids%小儿腺样体切除术后 OSAHS 复发原因探讨

    Institute of Scientific and Technical Information of China (English)

    周雪; 邵文叶

    2016-01-01

    腺样体肥大伴 OSAHS 是儿童常见疾病,手术治疗已成为主要治疗方法,但手术后 OSAHS 复发的案例不在少数,现根据各文献报导,分析腺样体肥大术后 OSAHS 复发的原因主要为:传统腺样体刮除术等手术未完全切除腺样体,合并分泌性中耳炎、鼻-鼻窦炎等临近器官疾病,扁桃体等淋巴组织代偿增生,肥胖等。积极治疗原发疾病,控制炎症发生是避免腺样体切除术后 OSAHS 复发的有效途径。%Adenoidal hypertrophy with OSAHS is a common childhood illness,surgery has become the main treat-ment,but recurrence after surgery OSAHS a few cases,on the basis of each reported in the literature,analyze the reasons of postoperative recurrence after resection of OSAHS in children adenoids mainly:Traditional adenoidectomy,such as sur-gery are not completely resection,combined secretory otitis media,rhinitis-sinusitis and other adjacent organs diseases, tonsils and other lymphoid tissue compensatory hyperplasia,obesity.Aggressive treatment of primary disease,control of inflammation is an effective way to avoid the recurrence of OSAHS after adenoidectomy.

  19. Clinical study of Shenling lavage solution on Nasopharyngeal lavation for 52 children with adenoid hypertrophy%参苓灌洗液治疗儿童腺样体肥大的临床观察

    Institute of Scientific and Technical Information of China (English)

    朱镇华; 江永忠

    2011-01-01

    目的 观察参芩灌洗液鼻咽腔灌洗治疗儿童腺样体肥大伴慢性鼻窦炎的疗效.方法 采用参苓灌洗液鼻咽腔灌洗治疗儿童腺样体肥大伴慢性鼻窦炎52例为治疗组,设对照组西药治疗51例,对比观察其临床疗效.结果 治疗组总有效率为94.2%,对照组为78.1%,差异有统计学意义(P<0.05).结论 参苓灌洗液局部灌洗有明显促进腺样体缩小和治疗鼻窦炎的作用.%Objective To investigate the curative effects of Shenling lavage solution on na-sopharyngeal lavation in children with adenoid hypertrophy accompanied with chronic sinusitis. Methods 52 patients were treated with this therapy in treatment group; other 51 children were treated with western medicine in control group. The curative effects were compared between two groups. Results The total effective rate was 94.2% in treatment group and 78.1% in control group (P<0.05). Conclusion The therapy of local lavation with Shenling lavage solution is effective to shrink the adenoid and cure the sinuses.

  20. 经鼻内镜儿童腺样体肥大高频电刀凝固手术29例体会%Experience of child adenoidal hypertrophy treated by high frequency electrocoagulation under nasal endoscopy in 29 cases

    Institute of Scientific and Technical Information of China (English)

    魏景旺

    2012-01-01

    Objective To explore the feasibility of the treatment by high frequency electrocoagulation under nasal endoscopy on adenoidal hypertrophy in children. Methods Twenty nine cases of adenoidal hypertrophy in children performed high frequency electrocoagula- tion under nasal endoscopy. Results The clinical improvement was significant including nasal obstruction, aural fullness, and breathing with mouth. There was no obvious complication of hemorrhage, postoperative hemorrhage, adenoid remnant, and atresia of pharyngeal opening of eu- stachian tube. All cases were followed up for 3~6 months, and there was no recurrence. Conclusion The treatment by high frequency electro-coagulation under nasal endoscopy on adenoidal hypertrophy in children has the advantages, such as no hemorrhage, no residue, slight trauma, short operative time, good security, simple equipments, which is suitable for basic level hospitals.%目的 探讨鼻内镜下高频电刀凝固术治疗儿童腺样体肥大的可行性.方法对29例患有腺样体肥大的儿童在鼻内镜直视下使用自制的高频电刀头进行凝固治疗.结果本组患者鼻塞、耳闷及张口呼吸等症状均获得明显改善,无术中或术后出血、咽鼓管咽口闭锁等并发症,随访3~6个月无腺样体残留复发.结论鼻内镜直视下儿童腺样体肥大高频电刀凝固术具有无出血、无残留、创伤小、手术时间短、安全性高、设备简单等优点,适合基层医院推广使用.

  1. Correlation analysis of EB virus infection and tonsils and adenoid hypertrophy in children%儿童EB病毒感染与扁桃体腺样体肥大的相关性分析

    Institute of Scientific and Technical Information of China (English)

    邹丽丽

    2015-01-01

    目的研究儿童EB病毒(epstein-barr virus,EBV)感染与扁桃体腺样体肥大的相关性。方法选取2013年6月~2014年6月期间我院收治的70例扁桃体腺样体肥大患儿,根据年龄、性别、体重等分为不同组别,比较不同组别之间的EBV感染情况。结果在70例扁桃体腺样体肥大患儿中,有47例伴EBV感染。其中男性66.67%(30/45),女性68.00%(17/25),两组之间无明显差异(P>0.05);学龄前期患儿感染率66.67%(22/33)和学龄期67.57%(25/37)无明显差异性(P>0.05);病程<30个月患儿感染率为62.50%(30/48),病程30~60个月为78.57%(11/14),病程>60个月为75%(6/8),三组之间无明显差异性(P>0.05);体重0~20 kg的患儿感染率为70.59%(12/17),20~40 kg为69.05%(29.42),40~60 kg为54.55%(6/11),不同体重感染率无明显差异性(P>0.05);打鼾患儿感染率为68.63%(35/51),不打鼾为63.16%(12/51),两组之间无明显的差异性(P>0.05)。结论儿童EBV感染与扁桃体腺样体肥大之间存在一定的关联性,扁桃体腺样体组织当中的EBV感染率和患者的年龄、性别、体重、病程长短等无明显相关性。%ObjectiveTo study the correlation of children epstein-barr virus(EBV)infection and tonsils and adenoid hyper-trophy in children.MethodsSeventy children with tonsil and adenoid hypertrophy from the June 2013 to June 2014 in our hospital were included in this research. According to the children age,sex, weight,etc,they were divided into different groups. And EBV infection was evaluated and compared.ResultsIn 70 cases of children with adenoid hypertrophy were tonsils,a total of 47 cases with EBV infection. Among the EBV-DNA positive cases,the male children accounted for 66.67%(30/45),while female patients accounted for 68.00%(17/25). There was no significant difference (P 0.05). The EBV infection rate in children with a

  2. MRI of cystic collection of the three joint; Les collections kystiques du genou en IRM

    Energy Technology Data Exchange (ETDEWEB)

    Boutry, N.; Cotten, A.; Dewatre, F.; Chastanet, P.; Gougeon, F. [Hopital R. Salengro, C.H.U., 59 - Lille (France)

    1997-09-01

    We present the main MR features of cystic lesions around the knee joint. Popliteal cysts are the most frequently seen. The usually result from extrusion of joint fluid into the gastrocnemio-semimembranosus bursa but they can have an atypical location or extension. They are most often due to a meniscal, ligamentous, degenerative or inflammatory joint disease responsible for a chronic joint effusion. Meniscal cysts are always associated with a horizontal tear. Medial meniscal cysts are larger and can extend far from the joint. Bursitis occur as a result of inflammation or infection of a bursa. Their location is stereotyped and they do not communicate with the knee joint. Ganglion cysts or ganglia are benign cystic lesions which can affect peri-articular tissues as well as subchondral bone or cruciate ligaments. MRI is now a simple and noninvasive way of obtaining etiologic diagnosis and guiding therapy. (authors). 46 refs.

  3. 三种不同手术治疗腺样体肥大对照研究%Comparative Study of Treating Adenoid Hypertrophy by Three Kinds of Surgical Modes

    Institute of Scientific and Technical Information of China (English)

    庞长安

    2015-01-01

    Objective To compare the effect between transnasal endoscopic adenoidectomy(TEA), endoscopic-assisted tran-soral adenoidectomy(ETA) and transoral curette adenoidectomy(TCA) on adenoid hypertrophy so as to provide reference for the treatment of adenoid hypertrophy. Methods 148 patients with adenoid hypertrophy underwent surgery in Department of ENT of our hospital from December 2010 to October 2013 were collected, and divided into TEA group(n=28), ETA group(n=34) and TCA group(n=86) in accordance with the surgical method. TEA group were treated by TEA, ETA group were treated by ETA, TCA group were treated by TCA. The improvement of clinical symptoms of the three groups was observed. And the clinical curative effect was compared among three groups. Results The cure rate of TEA group, ETA group, TCA group was respectively 60.7%, 61.8%, 34.9%, which showed that the cure rate of TEA group and ETA group was much higher than that of TCA group(P<0.05). The response rate of TEA group, ETA group, TCA group was respectively 32.1%, 29.4%, 22.1%, the response rate of TEA group and ETA group was much higher than that of TCA group (P<0.05). Conclusion Both TEA and ETA have higher overall cure rate and response rate than TCA, but ETA is better than TEA in the improvement of some clinical symptoms, therefore ETA may be the best surgical mode of adenoidectomy, and it is also suitable for those accompanied by nasal and paranasal sinus diseases.%目的:比较口腔鼻内镜腺样体切除术(TEA)、内镜辅助经口腔腺样体切除术(ETA)、经口腔腺样体刮除术(TCA)治疗腺样体肥大的疗效,为腺样体肥大的治疗提供参考。方法整群收集2010年12月—2013年10月在该院耳鼻喉科行手术治疗的腺样体肥大患者148例,根据手术方式分为TEA组(n=28)、ETA组(n=34)、TCA 组(n=86)。 TEA组采用TEA治疗,ETA组采用ETA治疗,TCA组采用TCA治疗,观察3组的临床症状改善情况,比较3组的临床疗效。结果TEA组

  4. Expression and significance of E-cadherin in adenoid cystic carcinoma of salivary glands%涎腺腺样囊性癌组织中E-钙黏蛋白的表达及临床意义

    Institute of Scientific and Technical Information of China (English)

    葛明华; 凌志强; 谭卓; 陈超; 徐加杰; 余江流

    2012-01-01

    Objective To examine the expression of E-cadherin and the methylation status of CDH1 and explore their clinical significance in salivary adenoid cystic carcinoma (SACC).Methods The expression of E-cadherin was detected by the immunohistochemical method.And the methylation of CDH1 gene promoter 5'-CpG island was analyzed by real-time methylation-specific polymerase chain reaction ( realtime MSP) in salivary adenoid cystic carcinoma and normal salivary gland tissue respectively.Results The expression rate of E-cadherin was lower in SACC than that in normal salivary gland tissue ( 100.0% vs 55.6%,P < 0.05).And the expression of E-cadherin was associated with different histopathological types,T-stage,nerve invasion,lymphatic and distant metastasis (P < 0.05).However,there was no correlation between the expression of E-cadherin and gender,age and tumor location.Partial methylation of CDH1 was detected in 3 of 30 cases with a positive expression of E-cadherin and full methylation of CDH1 in 23 of 24 cases with a negative expression of E-cadherin.There was a negative correlation between the expression of Ecadherin and the methylation of CDH1 in salivary adenoid cystic carcinoma ( r =- 0.483,P < 0.001 ).Conclusion The down-regulation of E-cadherin,as modulated by the methylation of CDH1,may contribute to nerve invasion,lymphatic and distant metastasis in SACC.Thus it may be used as a biological indicator of malignancy and prognosis.%目的 研究E-钙黏蛋白在涎腺腺样囊性癌(SACC)中表达水平、CDH1甲基化状态及临床意义.方法 用免疫组化的方法检测E-钙黏蛋白在SACC及正常涎腺组织中的表达,并用实时荧光甲基化特异性PCR分析CDH1甲基化状态.结果 与正常涎腺组织相比,E-钙黏蛋白在SACC表达低,差异有统计学意义(100.0%比55.6%,P<0.05),E-钙黏蛋白表达与组织病理学类型、T-分期、神经侵犯、淋巴结转移及远处转移相关(P<0.05);而与性别、年龄

  5. 儿童腺样体肥大的临床药物治疗效果分析%Effect analysis of clinical drug treatment for adenoid hypertrophy in children

    Institute of Scientific and Technical Information of China (English)

    汪姬婵

    2015-01-01

    Objective To analyze the clinical effect of medication treatment in children patients with adenoid hypertrophy .Methods 80 cases of child adenoid hypertrophy in the ear nose and throat outpatient department of our hospital from March 2014 to April 2015 were selected and grouped according to the random principle .The control group(40 cases) was given the mometasone furoate nasal spray for treatment ,while on this basis the observation group(40 cases) was combined with Montelukast Granules for treatment .The clinical therapeutic effects were com‐pared between the two groups .Results In the comparison of the breathing related sleep disorder indexes ,the symp‐tom scores after treatment in the control group and the observation group were(3 .3 ± 1 .1) and (0 .7 ± 0 .6) respec‐tively ;the cough time were(55 .7 ± 10 .5) d and(20 .0 ± 11 .1) d respectively ;the A/N ratios were(0 .8 ± 0 .1) and (0 .6 ± 0 .1) respectively ,the observation group was significantly better than the control group in the improvement of these 3 indexes ,and the differences were statistical significance(P< 0 .01) .Conclusion Adopting corticosteroids combined with leukotriene receptor antagonist agent in treating adenoidal hypertrophy in children has the advantages of relieving clinical symptoms and eliminating adverse body signs ,and is worthy of clinical promotion and use .%目的:探讨儿童腺样体肥大的临床药物治疗后的效果分析。方法选取2014年3月至2015年4月因患有腺样体肥大于耳鼻喉门诊就诊并治疗的患儿80例,按照随机分配的原则,40例采用糠酸莫米松鼻喷剂进行治疗的患儿为对照组,另40例在对照组患儿用药的基础上联合孟鲁司特钠颗粒进行治疗的患儿为观察组,比较两组患儿的临床治疗效果。结果在针对两组患儿治疗后呼吸相关睡眠障碍指标的比较中,对照组和观察组患儿在治疗后的症状评分分别为(3.3±1.1)、(0.7±0.6)

  6. Estudo comparativo radiológico e nasofibroscópico do volume adenoideano em crianças respiradoras orais Comparison between radiological and nasopharyngolaryngoscopic assessment of adenoid tissue volume in mouth breathing children

    Directory of Open Access Journals (Sweden)

    Edmir Américo Lourenço

    2005-02-01

    Full Text Available A tonsila faríngea ou adenóides é a extensão superior do anel linfático de Waldeyer e está localizada na porção alta da cavidade nasofaríngea, próxima à tuba auditiva e à coana. Ela desempenha um papel relevante nas otites médias recorrentes e freqüentemente sua hipertrofia é responsável pela obstrução das vias aéreas superiores. A tonsilectomia é um tratamento comumente realizado para doenças crônicas das tonsilas e ainda é o procedimento cirúrgico mais freqüente e mais antigo realizado em crianças e adultos jovens. Os critérios para a realização da tonsilectomia, o efeito da mesma na integridade imunológica do paciente e seus riscos inerentes à cirurgia são muito discutíveis e controversos em todo o mundo. Estudos de imagem utilizando-se o raio-X do cavo é um método simples, fácil e confortável para avaliar o tamanho das adenóides e o grau de obstrução das vias aéreas superiores. Um estudo nasofibroscópico da nasofaringe pode fornecer uma informação melhor sobre essa região, tendo em vista que ele mostra todas as estruturas presentes na nasofaringe e o grau de obstrução das vias aéreas superiores de forma dinâmica. FORMA DE ESTUDO: Clínico não randomizado. MATERIAL E MÉTODO: Este estudo comparou o grau de hipertrofia e de obstrução das vias aéreas superiores, usando os dois métodos acima, em crianças de 3 a 10 anos de idade, constatando que a nasofibroscopia flexível é um método diagnóstico excepcionalmente mais fidedigno do que o raio-x do cavo, na avaliação volumétrica da adenóide.The pharyngeal tonsil (adenoid constitutes the upper portion of the Waldeyer's ring and is located at the top of the nasopharynx, next to the auditory tube and choana. It plays an important role in recurrent otitis of the middle ear and many times its enlargement is responsible for upper airway obstruction. Tonsillectomy is often the treatment of choice for tonsillar diseases. So far, it is the most

  7. 糠酸莫米松鼻喷剂和孟鲁司特钠联合治疗儿童腺样体肥大的疗效观察%The treatment of adenoidal hypertrophy by mometasone furoate combined with montelukast

    Institute of Scientific and Technical Information of China (English)

    于亚峰; 吴文璎; 刘济生; 孙朋; 李满意; 肖根生

    2014-01-01

    目的:探讨儿童腺样体肥大的非手术治疗方法及其疗效。方法联合使用糠酸莫米松鼻喷剂和孟鲁司特钠治疗儿童腺样体肥大30例,按照腺样体大小分为轻度12例、中度11例、重度7例三组,同时按照有无变应性鼻炎分为伴变应性鼻炎组19例和不伴变应性鼻炎组11例。患者的症状评分根据Carlos O’Connor-Reina的家长调查问卷获得。结果轻度组中有效率91.7%(11/12),中度组有效率63.6%(7/11),重度组有效率14.3%(1/7)。伴变应性鼻炎组有效率73.7%(14/19),不伴变应性鼻炎组有效率36.4%(4/11)。结论糠酸莫米松鼻喷剂联合孟鲁司特钠是非手术治疗腺样体肥大一个较好的方法,但各组效果不一。轻度腺样体肥大效果较好,重度腺样体肥大效果较差。对于伴有变应性鼻炎的腺样体肥大治疗效果明显优于不伴有变应性鼻炎的。%Objective To explore the non-surgical treatment and efficacy of adenoidal hypertrophy in children. Methods 30 cases of adenoidal hypertrophy were treated with mometasone furoate (Nasonex) combined with montelukast (Singulair). All patients were divided into three groups (mild, moderate, severe) according to the size of adenoid. They were also divided into two groups according to the presence or absence of allergic rhinitis. Symptom scores of patients were acquired by Carlos O'Connor-Reina questionnaire. Results The efficiency in the mild group was 91.7% (11/12), in the moderate group was 63.6% (7/11) and in the severe group was 14.3% (1/7). The efficiency of adenoidal hypertrophy with allergic rhinitis group was 73.7% (14/19) and not with allergic rhinitis group was 36.4% (4/11). Conclusion Mometasone furoate combined with montelukast is a good non-surgical treatment of adenoidal hypertrophy. However, the effect is different for different patients. The efficiency is better for mild and moderate adenoid hypertrophy but poor for severe

  8. The expression of nm23 in salivary adenoid cystic carcinoma%肿瘤转移抑制基因nm23在涎腺腺样囊性癌表达的研究

    Institute of Scientific and Technical Information of China (English)

    彭歆; 俞光岩; 高岩; 武登诚

    2001-01-01

    Objective.To investigate the relationship between nm23 and the prognosis of patients with salivary adenoid cystic carci noma (SACC).Methods.The immunoactivity of nm23 of 52 cases with SACC was determined by immunohistochemistry method (Streptavidin-Biotin method).The relationship between nm23 and the histological type,clinical stage,local recurrence,distant metastasis of the tumor and survival rate of the patients with SACC were analysed.Results.Statistical analysis showed that the expression levels of nm23 were correlated inversely with distant metastasis potential (P<0.01),and had no significant relation with histo logical type,clinical stage,local recurrence and survival rate (P>0.05).Conclusion.The nm23 has a suppressive effect on distant metastasis of SACC and the evaluation of nm23 can act as a predictor of distant metastasis of SACC to direct the clinical treatment.%目的 探讨肿瘤转移抑制基因nm23与涎腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)预后的关系。方法 采用免疫组织化学链亲和素法分析52例SACC的nm23表达,并分析nm23与SACC病理学分型、临床分期、局部复发、远处转移和患者生存率的关系。结果  nm23表达与SACC病理学分型、临床分期、局部复发和患者生存率无明显相关(P>0.05 ),而与远处转移呈高度负相关关系(P<0.01)。结论 nm 23能抑制SACC远处转移的发生,并可作为预后指标来预测SACC的远处转移,指导临床治疗。

  9. Surgical treatment of children with adenoidal hypertrophy combined with obstructive sleep apnea%儿童腺样体肥大合并阻塞性睡眠呼吸暂停综合征的手术治疗

    Institute of Scientific and Technical Information of China (English)

    何植洲; 罗天飞; 李卫红; 李金奇; 李小娇; 谢志雄

    2013-01-01

      目的探讨儿童腺样体肥大合并阻塞性睡眠呼吸暂停综合征(OSAS)的治疗方法及临床疗效。方法对2011年4月~2012年9月我院耳鼻喉科收治的36例阻塞性睡眠呼吸暂停综合征患儿资料进行回顾分析,术后回访6~12个月。结果36例患儿均治愈,其中12例术后睡眠鼾声基本消失,无张口呼吸,憋醒及呼吸暂停等表现,24例憋醒,张口呼吸,呼吸暂停及睡眠打鼾等症状完全消失。术后回访6~12个月,无一例并发症且无一例复发。结论对于儿童腺样体肥大合并阻塞性睡眠呼吸暂停综合征患儿,鼻内镜下腺样体切除术治疗,临床疗效确切,值得进一步推广。%Objective To explore the treatment method and clinical effect of adenoidal hypertrophy in children with obstructive sleep apnea syndrome (OSAS). Methods 36 cases of children with obstructive sleep apnea were analyzed retrospectively by interview 6 -12 months after surgery,from April 2011 to September 2012 in ENT department of our hospital. Results 36 cases of patients were cured,12 cases of postoperative sleep snoring disappeared,no mouth breathing,arousal and apnea. 24 cases had arousal,mouth breathing,and sleep apnea and snoring and other symptoms disappeared completely. There was no case of complication and recurrence. Conclusion Endoscopic adenoidectomy treatment for the adenoidal hypertrophy with obstructive sleep apnea syndrome,is worthy of further promotion,and the effect is exact.

  10. 基因XAGE-1b在唾液腺腺样囊性癌中的表达及意义%Gene Tiam1 and XAGE~1b’s expression and significance in salivary adenoid cystic carcinoma

    Institute of Scientific and Technical Information of China (English)

    刘屹嵩; 樊开斌; 宋建强; 闫征斌

    2014-01-01

    Objective:To detected the expression of Tiam1 and XAGE-1b in ACC and normal salivary gland tissue and investigated the correlation of the two genes with ACC stage , tumor size , lymph node metastasis , patient age and gender .Methods:Immunohistochem-istry was used to detect the expression of KAI 1 and Tiam1 in 40 cases of ACC and normal salivary gland tissues .Results:The Tiam1 and XAGE-1b positive expression rate was significantly higher than that in normal salivary gland tissue (P0.05); between the two proteins positive expression was positively correlated (P <0. 05).Conclusion:Tiam1 XAGE-1b and the occurrence of abnormal expression of ACC , metastasis and prognosis, the joint detection of the expression of KAI 1 and Tiam1 is expected to become the ACC's early diagnosis , prognostic molecular markers .To further explore the adenoid cystic carcinoma of the pathogenic mechanism and significance of providing a theoretical basis and experimental evidence .%目的:检测XAGE-1b在腺样囊性癌(adenoid cystic carcinoma, ACC)组织和正常涎腺组织中的表达,并探讨XAGE-1b的表达在ACC发生发展中的作用。方法:应用免疫组织化学方法检测40例ACC组织和正常涎腺组织中XAGE-1b的表达,分析其与临床病理的关系。结果:ACC组织中XAGE-1 b阳性表达率显著高于正常涎腺组织( P<0.05);XAGE-1 b表达与TNM分期、肿瘤直径及淋巴结转移有关(P<0.05),而与患者年龄、性别无关(P>0.05)。结论:XAGE-1b异常表达与ACC的发生、转移及预后密切相关,检测XAGE-1b的表达有望成为ACC的早期诊断、预后评估的分子指标,为进一步探讨涎腺腺样囊性癌的致病机制及意义提供了理论基础和实验依据。

  11. Clinical study on montelukast treatment for adenoidal hypertrophy in children%孟鲁司特钠治疗儿童腺样体肥大的临床疗效

    Institute of Scientific and Technical Information of China (English)

    汤海玲; 曹园园

    2013-01-01

    目的 探讨孟鲁司特钠治疗儿童腺样体肥大(AH)的可行性及临床疗效.方法 选择2010年6月至2012年6月我院收治的上气道咳嗽综合征合并AH患儿120例,依据随机对照原则分为观察组(60例)与对照组(60例),所有病例使用抗生素治疗及对症治疗,观察组给予孟鲁司特钠治疗16周,对照组同期给予安慰剂.观察两组患儿治疗前后咳嗽持续天数、呼吸相关睡眠障碍症状指标评分及腺样体/鼻咽比值(A/N比值)的改变.结果 所有患者均顺利完成16周治疗.观察组治疗前后咳嗽持续天数、呼吸相关睡眠障碍症状指标评分及A/N比值比较差异有统计学意义(P0.05);观察组与对照组治疗前上述指标比较差异无统计学意义,与治疗后比较差异有统计学意义(P 0. 05 ); before the therapy, there was no significant difference for all the above-mentioned index between the experiment group and the control group, while after the therapy,there were significant differences between the two groups( P < 0. 05 ). Conclusion Montelukast has good clinical effect in children with upper respiratory cough syndrome complicated with adenoidal hypertrophy, it is able to reduce cough days, and improve the sleep disorder and reduced the size of the adenoid.

  12. 变应性鼻炎伴腺样体肥大患儿应用丙酸氟替卡松喷剂治疗的临床对照研究%Controlled Clinical Studies on Fluticasone Propionate Spray for Allergic Rhinitis Children Suffering with Adenoidal Hypertrophy

    Institute of Scientific and Technical Information of China (English)

    吴莉; 姜妍; 沈莹

    2016-01-01

    Objective:To research the efficacy and safety of fluticasone propionate spray for allergic rhinitis children suffering with adenoidal hypertrophy. Methods:Totally 160 allergic rhinitis with adenoids growth children were in the observation group, in which 109 cases were diagnosed as adenoidal hypertrophy. Totally 157 adenoids growth children were in the control group, in which 114 cases were diagnosed as adenoidal hypertrophy. The two groups both received fluticasone propionate spray treatment for 3 months, and then the nasal endoscopic adenoidectomy volume, symptom score and adverse reactions were observed and analyzed. Results:Allergic rhi-nitis children suffering with adenoidal hypertrophy were mainly in the 3-6-year-old children. After the treatment, adenoids was shrinked in 88 patients (80. 73%) in the observation group, which was significantly higher than that in the control group [67(58. 77%), P<0. 01]. Adenoidal hypertrophy was still in 44 patients (35. 03%) of the observation group after the treatment, which was lower than that of the control group [55(68. 13%), P <0. 05]. In addition, the integral differences of nasal congestion, snoring and mouth breathing in the observation group after the treatment were higher than those in the control group, and the differences were statistically significant (P<0. 05). Conclusion:The efficacy of fluticasone propionate spray used in allergic rhinitis children suffering with adenoi-dal hypertrophy is more obvious than that in adenoid hypertrophy children, which can more significantly improve the symptoms of nasal congestion, snoring and mouth breathing.%目的::研究变应性鼻炎伴腺样体肥大患儿应用丙酸氟替卡松喷剂治疗的有效性和安全性。方法:选择变应性鼻炎伴腺样体生长的患儿160例做为观察组,其中腺样体肥大者109例;选择同期单纯腺样体生长的患儿157例做为对照组,其中腺样体肥大者114例。两组患儿均接受

  13. Expression and significance of S-100 and GFAP in lacrimal adenoid cystic carcinoma%泪腺腺样囊性癌 S-100蛋白、神经细丝酸性蛋白的表达及其意义

    Institute of Scientific and Technical Information of China (English)

    王磊峰; 董玉萍; 朱素芳; 李晓娟; 董秋艳; 黑砚

    2014-01-01

    Objective To investigate the expression of Schwann's cell markers S-100 and GFAP in lacrimal adenoid cystic car-cinoma, and to explore the relationship between GFAP or S-100 expression and neural invasion of adenoid cystic carcinoma. Methods Twenty-eight lacrimal adenoid cystic carcinoma and 9 normal lacrimal gland specimens were collected .Each specimen was stained by S-P( streptavidin/peroxidase) immuno-histochemical staining.The expression of S-100 and GFAP was analyzed by immuno-histochemistry in order to find the difference in the above-mentioned tissues.One-way ANOVA, Student,s test, chi-square test or line-ar correlation were carried out for statistical evaluation.Results The average S-100 Index(S-100LI) in nor-neural invasion group and neural invasion group were 0.62 ±1.19 and 16.73 ±24.74,respectively,in lacrimal gland adenoid cystic carcinoma.(P<0.05). The average GFAP LI in nor-neural invasion group and neural invasion group were 0 and 2.07 ±3.01,respectively,in lacrimal gland adenoid cystic carcinoma.(P<0.05).Conclusions Schwann’s cell markers GFAP and S-100 in neural invasion group is higher than that in nor-neural invasion group (P<0.05).The Schwann’s cell differentiation may account histologically for the neural inva-sion of lacrimal gland adenoid cystic carcinoma.%目的:探讨泪腺腺样囊性癌S-100蛋白及神经细丝酸性蛋白( glial fibrillary acidic protein, GFAP)的表达及其意义。方法收集手术切除泪腺腺样囊性癌28例标本,根据临床症状及组织学观察分为嗜神经侵袭组(15例)和无嗜神经侵袭组(13例),并取术中切除的正常泪腺组织9例为正常对照。应用免疫组织化学SP染色法检测S-100及GFAP在上述组织中表达的差异。结果嗜神经侵袭性生长组的S-100、GFAP阳性表达分别为12例(80%)和9例(60%),与无嗜神经侵袭性生长组S-100阳性5例(41.67%)、GFAP阳性表达率为0相比,呈显著升高趋势

  14. Application Value of Dual-source CT Low-dose Scanning in the Diagnosis of Adenoidal Hypertrophy in Children%双源CT低剂量扫描在诊断儿童腺样体肥大中的应用价值

    Institute of Scientific and Technical Information of China (English)

    王守玺

    2014-01-01

    Objective To evaluate and analyze the application value of dual-source CT low-dose scanning in the diagnosis of ade-noidal hypertrophy in children, so as to provide reliable reference for future clinical diagnostic work. Methods 76 cases of children clinically diagnosed as adenoidal hypertrophy admitted in our hospital from January, 2011 to December, 2013 were extracted. And they were divided into the control group and the observation group in accordance with the order of admission. The control group was given dual-source CT conventional-dose scanning, and the observation group was given dual-source CT low-dose scanning, the image quality, radiation dose and diagnostic results of both groups were compared and analyzed. Results There was no signifi-cant difference in the result of nasopharyngeal anatomy display between the observation group and the control group ( P>0.05), but the difference in adenoid CT value and radiation dose between the two groups was significant (P0.05),两组患儿腺样体CT值和辐射剂量比较存在差异有统计学意义(P<0.05)。结论经双源CT低剂量扫描可对儿童腺样体肥大做出准确的诊断,且其安全性较常规剂量扫描更高,临床诊断价值显著,值得关注并推广。

  15. Bcl-2、NF-KB在腮腺腺样囊性癌中的表达及临床意义%Expression and clinical significance of Bcl-2、NF-KB in adenoid cystic carcinoma of the parotid gland

    Institute of Scientific and Technical Information of China (English)

    张新华; 南欣荣

    2013-01-01

    目的:探讨Bcl-2和NF-KB在腮腺腺样囊性癌中的表达及意义.方法:应用免疫组化SP法检侧49例腮腺腺样囊性癌和20例正常腮腺组织中Bcl-2和NF-KB的表达情况,统计学分析采用x2检验,P<0.05判断为具有显著性差异.结果:Bcl-2和NF-KB的表达强度显著高于正常腮腺组织(P<0.05),Bcl-2、NF-KB的表达与病理无关(P>0.05),与TNM分期有关,Bcl-2和NF-KB两者存在正相关性(P<0.05,Kappa=0.387).结论:在腮腺腺样囊性癌的发生、发展过程中NF-KB通过上调Bcl-2的表达发挥作用.%Objective To explore the expression and Clinical Significance of Bcl-2,NF-KB in in Adenoid Cystic Carcinoma of the Parotid Gland.Methods Detected the expression of Bcl-2,NF-KB gene protein in 49 cases of adenoid cystic carcinoma of parotid gland was block embedded tissue in Immunohistochemistry SP method,20 cases of normal parotid tissue as control.Using x2 test,the statistically significant difference is defined as P<0.05.Results The total expression rate of Bcl-2 and NF-KB in adenoid cystic carcinoma group are significantly higher than the normal parotid group (P<0.05),the expression of different pathological typing of Bcl-2 and NF-KB are no differences (P > 0.05),the expression of clinical TNM stage of Bcl-2 and NF-KB are differences (P<0.05).There is positive correlation between Bcl-2 and NF-KB (P<0.05 kappa=0.387).Conclusion NF-KB plays a important role by up-regulating the expression of Bcl-2 in the occurrence and development process of adenoid cystic carcinoma of parotid gland.

  16. Adjacent patterns between adenoid and eustachian cushion and its clinical relation with otitis media with effusion%腺样体与咽鼓管圆枕的毗邻关系及其与分泌性中耳炎的相关性

    Institute of Scientific and Technical Information of China (English)

    杨柳; 孙文锴; 蔡蕾; 田滢

    2015-01-01

    目的观察腺样体肥大儿童的腺样体与咽鼓管圆枕的毗邻关系,探讨其与分泌性中耳炎的相关性。方法144例腺样体肥大(或同时扁桃体肥大)70°鼻内镜下行等离子消融术患儿,术中观察并记录腺样体与咽鼓管圆枕的毗邻关系,并将其分为Ⅰ、Ⅱ、Ⅲ共3型;比较3组患儿分泌性中耳炎发病率、腺样体重度肥大(A/N比值是否大于0.7)的发生率并计算有无统计学差异。结果本组患儿分泌性中耳炎发病率23.6%;腺样体与咽鼓管圆枕的毗邻关系及合并分泌性中耳炎,Ⅰ型3例(9.1%,3/33)、Ⅱ型10例(16.9%,10/59)、Ⅲ型21例(40.4%,21/52),Ⅰ型与Ⅱ型分泌性中耳炎发生率无显著性差异(χ2=1.077,P=0.299),Ⅰ型与Ⅲ型有显著性差异(χ2=9.757,P=0.002),Ⅱ型与Ⅲ型有显著性差异(χ2 =7.542,P=0.006);Ⅰ型和Ⅱ型组腺样体A/N>0.7之和为34.9%,三型组A/N>0.7为82.2%,Ⅰ型及Ⅱ型腺样体重度肥大率之和与Ⅲ型有显著性差异(χ2=30.556,P=0.000)。结论腺样体与咽鼓管圆枕毗邻关系及腺样体的肥大程度与分泌性中耳炎有显著相关性。%OB J ECT I V E To explore the adjacentpatterns between adenoid and Eustachian cushion in hypertrophic adenoid children and to study its relationship with otitis media with effusion(OME). METHODS A retrospective analysis was conducted in 144 cases of pediatric adenoidal hypertrophy(or concurrenttonsil hypertrophy) admitted for adenoid ablation under the 700 nasal endoscope. Children were divided into 3 groups(TypeⅠ, Ⅱ and Ⅲ) according to adjacentpatterns between adenoid and Eustachian cushion.The incidence of OME, severe hypertrophy of adenoid(A/N>0.7) in differentgroup were analyzed. RESULTS There were 34 children (23.6%) with OME, 3 (9.1%) in type Ⅰ, 10(16.9%) in type Ⅱ and 21(40.4%) in type Ⅲ. No significantdifference was existed between the incidence of OME in type

  17. 腺样体肥大切除术后对儿童鼻窦炎治疗转归的影响分析%Analysis of the influence of adenoid hypertrophy resection postoperation on the treatment outcome of children sinusitis

    Institute of Scientific and Technical Information of China (English)

    崔云东; 田双双

    2014-01-01

    Objective:To explore the influence of using adenoid hypertrophy resection therapeutic schedule on the treatment outcome of sinusitis in children with sinusitis.Methods:40 children with sinusitis were selected from July 2012 to June 2013.They were given adenoid hypertrophy resection,and used drugs treatment after operation.The clinical curative effect of children was observed.Results:40 children were implemented adenoid hypertrophy resection.21 cases were excellent;17 cases were effective;2 cases were invalid;the total effective rate reached 95% .There was no related complications.Conclusion:In the children with sinusitis,the application of adenoid hypertrophy resection therapeutic schedule is safe and reliable;the clinical curative effect is better;related complication is less.It is worthy of popularization and application.%目的:探讨在鼻窦炎患儿中,应用腺样体肥大切除术的治疗方案对于鼻窦炎治疗转归的影响。方法:2012年7月-2013年6月收治鼻窦炎患儿40例,对其进行腺样体肥大切除术,手术后使用药物辅以治疗,观察患儿的临床治疗效果。结果:对40例患儿实施腺样体肥大切除术,显效21例,有效17例,无效2例,总有效率达到95.0%,没有相关并发症发生。结论:在鼻窦炎患儿中,应用腺样体肥大切除术的治疗方案安全可靠,且临床疗效较好,相关并发症的发生情况少,值得推广应用。

  18. Avaliação da pressão inspiratória em crianças com aumento do volume de tonsilas Evaluation of inspiratory pressure in children with enlarged tonsils and adenoids

    Directory of Open Access Journals (Sweden)

    Melissa Guerato Pires

    2005-10-01

    Full Text Available Crianças com aumento do volume de tonsilas palatina e faríngea freqüentemente apresentam anormalidades respiratórias tais como ronco, respiração oral e apnéia do sono. Sabe-se que a obstrução de vias aéreas superiores e conseqüentemente a respiração oral podem resultar em problemas pulmonares. OBJETIVO: Avaliar a pressão inspiratória em crianças com obstrução de vias aéreas superiores devido ao aumento do volume de tonsilas. FORMA DE ESTUDO: clínico com coorte transversal. MATERIAL E MÉTODO: Nós avaliamos 37 crianças (4-13 anos, ambos os sexos com aumento do volume de tonsilas que seriam submetidas à cirurgia de Adenoamigdalectomia na Divisão de Otorrinolaringologia da Universidade de São Paulo no mesmo período. O grupo controle foi composto de 28 crianças sem aumento de volume tonsilar que foram submetidas aos mesmos testes. A pressão Inspiratória foi obtida pelo uso do manovacuômetro. RESULTADOS: Observamos uma menor pressão inspiratória no grupo com aumento do volume de tonsilas. A média do grupo com aumento do volume das tonsilas foi 14,607 cm/H2O e do grupo normal foi de 27,580 cm/H2O (PChildren with enlarged tonsils and adenoids usually present breathing abnormalities such as snoring, mouth breathing and sleep apnea. It is known that upper airway obstruction and consequent mouth breathing may result in pulmonary diseases. AIM: The goal of this preliminary study was to evaluate the inspiratory pressure in children with upper airway obstruction due to enlarged tonsils. STUDY DESIGN: clinical with transversal cohort. MATERIAL AND METHOD: We evaluated 37 children (4 -13 years old, female/male with enlarged tonsils who would be submitted to a T&A surgery in the Department of Otolaryngology, Medical School, University of Sao Paulo, from October 2002 to March 2003. The control group comprised 28 children without tonsillar disease submitted to the same tests. Inspiratory pressure was obtained using a manometer and

  19. Morphological heterogeneity of oral salivary gland carcinomas: a clinicopathologic study of 41 cases with long term follow-up emphasizing the overlapping spectrum of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.

    Science.gov (United States)

    Schwarz, Stephan; Müller, Maximilian; Ettl, Tobias; Stockmann, Philipp; Zenk, Johannes; Agaimy, Abbas

    2011-04-01

    We analyzed 41 oral salivary gland carcinomas from consecutive 290 salivary gland carcinoma database (14%) with emphasis on the histological spectrum and clinical outcome of adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA). The cohort included 14 ACCs, 14 mucoepidermoid carcinomas (MECs), 8 PLGAs, 3 adenocarcinomas, not otherwise specified and 2 acinic cell carcinomas. Mean age was 48, 58 and 61 yrs for ACC, MEC and PLGA, respectively. Eight patients (19.5%) died of tumor at a mean interval of 66.5 months. ACC and PLGA showed similar mean age, gender distribution, predominant palatal localization, nodal metastasis, perineural invasion and MIB-1 index. However, ACC tended to show higher tumor stage and residual tumor (R1/R2) more frequently than PLGA, but this was statistically not significant. ACC and PLGA showed overlapping architectural patterns. However, ACCs displayed well organized basal-luminal differentiation, highlighted by CK5/CK7 immunostaining. In contrast, PLGA showed a disorganized histological and immunohistological pattern. C-Kit expression (CD117) was common in ACC, generally mirroring that of CK7 and virtually lacking in PLGA. Kaplan-Meier analysis demonstrated a similar clinical course for ACC and PLGA with 5 years survivals of 87% and 80%, respectively. Fluorescence in situ hybridization (FISH) performed on all 290 salivary carcinomas confirmed the specificity of the translocation t (11; 19) for MEC and its absence in all other carcinomas including ACC and PLGA. Our results emphasize the diversity of oral salivary gland carcinomas and the overlapping clinicopathological features of ACC and PLGA.

  20. Clinical effect of endoscopic low-temperature plasma radiofrequency in the treatment of 43 cases of adenoid hypertrophy%鼻内镜下低温等离子消融术治疗腺样体肥大43例临床分析

    Institute of Scientific and Technical Information of China (English)

    黄辉; 钟晓燕; 廖艳萍

    2015-01-01

    Objective To observe the clinical effect of the low-temperature plasma endoscopic adenoidec-tomy in the treatment of adenoid hypertrophy. Methods Eighty-six patients with adenoid hypertrophy were ran-domly divided into control group and observation group, with 43 cases in each group. The control group adopted the nasal endoscopic adenoidectomy, while the observation group used low-temperature plasma endoscopic adenoidecto-my. The situation of surgery, therapeutic effect, follow-up recurrence and complications of the two groups were ob-served. Results The length of hospital stay and intraoperative blood loss in the observation group were significantly less than those in the control group, (6.0±1.2) d vs (9.5±1.3) d and (57.2±3.1) ml vs (72.4±3.4) ml, P0.05. The recurrence rate of adenoid hypertrophy and the rate of postoperative residual ade-noid body were 0%and 2.3%in the observation group, 2.3%and 4.7%in the control group, with no statistically signif-icant difference between the two groups (P>0.05). Conclusion Low-temperature plasma endoscopic adenoidectomy in the treatment of adenoid hypertrophy results in good clinical effect and fewer complications, which is worthy of clinical popularization and application.%目的:观察鼻内镜下低温等离子消融术治疗腺样体肥大的临床效果。方法选择我院收治的86例腺样体肥大患者为研究对象,随机将其分为对照组和观察组,每组各43例。对照组采用鼻内镜下腺样体吸切术治疗,观察组采用鼻内镜下低温等离子消融术治疗。比较两组患者的手术情况、治疗效果、随访复发和并发症发生情况。结果观察组患者的住院时间(6.0±1.2) d、术中出血量(57.2±3.1) ml,均明显少于对照组的(9.5±1.3) d和(72.4±3.4) ml,差异均有统计学意义(P0.05);观察组患者腺样体肥大复发率为0,腺样体术后残留率为2.3%,对照组腺样体肥大复发率为2.3%,腺样体术后残留率为4.7%,

  1. Clincal Observation on Chronic Sinusitis and Adenoidal Hypertrophy in Children Treated with Bi-yuan-shu Oral Liquid%鼻渊舒口服液治疗儿童慢性鼻窦炎伴腺样体肥大的临床研究

    Institute of Scientific and Technical Information of China (English)

    李瑾

    2012-01-01

    Objective: To explore the relation between chronic sinusitis and adenoidal hypertrophy and the effect of adenoidec-tomy with debrider on the development of chronic sinusitis in children. Methods: Eighty cases pediatric chronic sinusitis with adenoidal hypertrophy were performed transoral adenoidectomy with nasal endoscopy, Xomed power system and video monitoring under general anesthesia, meanwhile general therapy was applied for them. Results: All surgeries were successful and all cases were recovered without bleeding and complications. After adenoidectomy the clinical symptom improved obviously. The disease was cured in 72 patients, progressive in 6, and not improved in 2. The response rate was 97.5%. Follow up for 6 ~ 12 months found no recurrence and complications. Conclusion: There are some relation between adenoidal hypertrophy and chronic sinusitis in children. Therefore nasal endos-copy-assisted adenoidectomy with debrider was an minamally invasive and more effective treatment for chronic sinusitis with adenoidal hypertrophy in children. It was an effective method that the treatment of chronic sinusitis with adenoidal hypertrophy in children%目的:探讨中成药制剂鼻渊舒口服液治疗儿童慢性鼻窦炎伴腺样体肥大以及腺样体吸割术对儿童慢性鼻窦炎疗效的影响.方法:对80例慢性鼻窦炎经非手术治疗无效且伴腺样体肥大的儿童,采用XPS动力吸割系统及鼻内镜,在电视显示系统监视下行腺样体吸割术,术后辅以中成药鼻渊舒口服液治疗,观察其疗效.结果:80例患儿手术经过顺利,术后无出血及并发症发生,慢性鼻窦炎及腺样体肥大所引起的相关临床症状改善明显.术后慢性鼻窦炎经药物治疗后治愈72例,好转6例,无效2例,有效率97.5%.随访6-12个月,无复发及远期并发症.结论:儿童慢性鼻窦炎与腺样体肥大之间有一定的相关性,术后应用中成药鼻渊舒口服液具有良好的治疗效果,可作为儿

  2. IBP促进人涎腺腺样囊性癌细胞对紫杉醇耐药%IRF-4 binding protein promotes resistance of human salivary adenoid cystic carcinoma cells to taxol

    Institute of Scientific and Technical Information of China (English)

    熊剑; 常慧君; 李鹏; 范舒; 申涛; 简从相; 周继祥; 胡川闽

    2012-01-01

    目的 探讨IBP对SACC细胞抗紫杉醇凋亡能力的影响及其机制.方法 将ACC2转染IBP组和空白对照组各自根据不同紫杉醇浓度分成5组,紫杉醇作用72h后,MTT法检测在紫杉醇作用下IBP对SACC细胞增殖的影响;通过微管蛋白Tubulin免疫荧光染色,观察紫杉醇作用前后ACC2细胞微管的变化及IBP与微管的关系.结果 IBP使ACC2细胞对紫杉醇产生一定程度的耐药,在5μg/ml的紫杉醇浓度下最为明显;紫杉醇开始作用后,ACC2-C1细胞的微管点状聚集成团,而ACC2-C1/IBP细胞的微管则出现明显的紊乱、断裂,IBP能促进微管的解聚;IBP所发的绿色荧光与微管的红色荧光糅合在一起呈黄色,IBP与微管存在一定程度的共定位.结论 IBP促进SACC细胞对紫杉醇耐药.%Objective To study the effect of IRF-4 binding protein (IBP) on resistance of salivary adenoid cystic carcinoma (SACC) cells to taxol and its mechanism. Methods ACC2 cells transfected with IBP and blank control cells (ACC2-C1 cells) were divided into 5 groups according to their taxol concentration. Effect of IBP on proliferation of SACC cells was detected by MTT assay 72 h after taxol was used. Occurrence of changes in microtubules of SACC cells and its relation with IBP were observed with tubulin immunofluorescence staining before and after taxol was used. Results IBP increased the resistance of ACC2 cells to taxol, especially at the concentration of 5 μg/ml. The point-like microtubules of ACC2-C1 cells aggregated into a clump while the microtubules of ACC2-C1/ IBP cells were arranged in disorder and fractured, indicating that IBP can promote depolymerization of microtubules. Green fluorescence of IBP and red fluorescence of microtubules were merged as a yellow color, showing that IBP and microtubules are located at the same site. Conclusion IBP promotes resistance of SACC cells to taxol.

  3. The clinical research on the treatment of the low temperature plasma radiofrequency ablation through the mouth under endoscope in adenoid hypertrophy of children%鼻内镜下低温等离子射频消融治疗儿童腺样体肥大的临床研究

    Institute of Scientific and Technical Information of China (English)

    毛贺娟; 蒋蓉; 陈艳辉; 赵倩; 颜光堂; 程奇; 王建洪; 肖世强

    2014-01-01

    目的:探讨鼻内镜下经口低温等离子射频消融治疗儿童腺样体肥大的临床疗效。方法回顾性分析98例患腺样体肥大的儿童对于不同治疗手段的疗效情况,分为试验组50例和对照组48例,其中试验组给予鼻内镜下低温等离子射频消融术,对照组给予传统腺样体刮除术,并分析比较两组患儿的手术时间、术中出血量及住院时间,并随访1年,比较观察患儿的鼻塞、打鼾和听力等临床症状,以及患儿术后残留、复发及并发症发生情况。结果与对照组比较,试验组的术中出血量明显低于对照组,且差异有统计学意义(P<0.05);试验组术后鼻塞、打鼾和听力等临床总有效率分别为86.0%(43/50)、80.0%(40/50)、76.0%(38/50),明显高于对照组的68.8%(33/48)、60.4%(29/48)、54.2%(26/48),差异有统计学意义(P<0.05);试验组术后仅1(2.0%)例腺样体残留,且未见腺样体肥大复发,对照组术后腺样体残留率58.3%(28/48),腺样体肥大复发率16.7%(8/48),两组比较差异有统计学意义(P<0.05),且两组术后均未见严重并发症发生。此外,对两组进行未复发率分析及Log-rank检验,差异有显著性意义(P<0.05)。结论鼻内镜下低温等离子射频消融治疗儿童腺样体肥大临床疗效好,术中出血量少,术后无复发和其他并发症发生,可作为手术治疗儿童腺样体肥大的首选方法。%Objective To investigate the low temperature plasma radiofrequency ablation through the mouth under endoscope clinical curative effect for the treatment of adenoid hypertrophy in children. Methods A retrospective analysis of 98 cases of children with adenoid hypertrophy were to the curative effect of different treatments, 50 cases were divided into test group and control group, 48 cases of experimental group gives the low-temperature plasma

  4. Clinical observation of sublingual dermatophagoides farinae treatment of allergic rhinitis with adenoid hypertrophy in children%舌下含服粉尘螨滴剂治疗儿童变应性鼻炎合并腺样体肥大的临床观察

    Institute of Scientific and Technical Information of China (English)

    谢小娟; 文春秀; 甘金梅; 蒋鸣惊; 莫誉华; 黄跃

    2015-01-01

    Objective:To investigate the clinical effect of sublingual dermatophagoides farinae drops on allergic rhinitis with adenoid hypertrophy in children.Methods:Diagnosis for allergic rhinitis with adenoid hypertrophy of 64 cases were randomly divided into two groups,study group under the tongue with dermatophagoides farinae drops in treatment and control group for the simple routine anti allergy drug treatment were observed for 2 years,changes in VAS scores were recorded at children with nasal allergies such as nasal congestion,nasal itching,sneezing and runny nose and sleep snoring symptoms,by nasal endoscopy to observe the changes of the size of adenoids.Results:The VAS score of nasal allergic symptoms in the study group was significantly decreased (P <0.05)compared with that before treatment.There was significant difference in the VAS score between the two groups after treatment (P<0.05).After treatment,the symptoms such as snoring in the study group were signifiG cantly lower than those in the treatment group (P <0.05),and the symptoms such as snoring and VAS scores were significantly lower than those in the control group (P<0.05);and the two groups of adenoid body size compared with the treatment before the reduction of the difference between the two groups (P<0.05),the comparison between the groups were significantly different (P<0.05).ConcluG sion:The tongue with dermatophagoides farinae drops can effectively control children with allergic rhiG nitis with adenoid hypertrophy of the stuffy nose,nasal itching,sneezing,runny nose,sleep snoring and adenoid body size,as the non operative treatment of allergic rhinitis with adenoid hypertrophy clinical method.%目的::探讨舌下含服粉尘螨滴剂对儿童变应性鼻炎合并腺样体肥大的临床治疗效果.方法:将64例变应性鼻炎合并腺样体肥大患儿随机分为两组,研究组为舌下含服粉尘螨滴剂治疗,对照组为单纯常规抗过敏药物治疗,观察2年,采用 VAS

  5. 对腺样体肥大儿童进行CT多平面重建与仿真内镜检查的诊断价值%The Diagnostic Value of CT Multiplanar Reconstruction and Virtual Endoscopy in Pediatric Adenoidal Hypertrophy

    Institute of Scientific and Technical Information of China (English)

    刘伟; 陈刚; 王卉

    2016-01-01

    目的:探讨螺旋CT多平面重建与仿真内镜技术在儿童腺样体肥大中的诊断价值。方法:将60例4-13岁腺样体肥大的儿童随机分为实验组和对照组(每组30例)。实验组行鼻咽部CT扫描及鼻内镜检查,并使用CT扫描机同机工作站进行仿真内镜检查,构建重组图像。对照组行鼻咽侧位X线平片扫描及鼻内镜检查。两组均通过蝶-枕骨结合部层面,测量正中矢状位腺样体最大厚度与鼻咽腔前后径比值(A/N)、与鼻内镜直视下腺样体肥大的分度进行比较。结果:螺旋CT多平面重建图像能清晰、全面地显示腺样体肥大的程度及其与周围结构的关系。实验组患者中腺样体轻度肥大6例,中度肥大15例,重度肥大9例,与鼻内镜检查结果相符;仿真内镜下可见肥大的腺样体占据后鼻孔:I度阻塞2例,II度阻塞6例,III度阻塞106例,IV度阻塞12例,与鼻内镜检查结果一致(P=0.431)。对照组患者中腺样体轻度肥大5例,中度肥大8例,重度肥大17例,与鼻内镜检查差异有统计学意义(P=0.009)。结论:螺旋CT多平面及仿真内镜检查可更准确、全面、客观地提供腺样体的测量数据,在儿童腺样体肥大的诊断上较鼻咽侧位X线平片具有更高的临床应用价值。%Objective: To explore the diagnostic value of CT multiplanar reconstruction and virtual endoscopy in Pediatric Adenoidal Hypertrophy. Method: A total of 60 children aged 4-13 years were diagnosed with Pediatric Adenoidal Hypertrophy. 30 cases were examined by nasal endoscope and scanned by nasopharyngeal CT with image construction of virtual endoscopy, 30 cases were examined by nasal endoscope and nasopharyngeal lateral X-ray. Two groups measured the maximum thickness of adenoid diameter of nasopharyngeal air space ratio(A/N), then compared with the indexing of adenoid hypertrophy under nasal endoscop. Results: CT multiplanar

  6. Low Temperature Coblation of Adenoid Combines With Dissection Tonsillectomy in Treatment of Children OSAHS%腺样体低温等离子消融术联合扁桃体摘除术治疗儿童OSAHS的疗效观察

    Institute of Scientific and Technical Information of China (English)

    徐文萍

    2015-01-01

    Objective To evaluate the effectiveness of combining low temperature coblation of adenoid with dissection tonsillectomy in the treatment of OSAHS.MethodsA retrospective study,including 23 children with OSAHS, whose diagnoses were made based on polysomnography (PSG) and laryngoscopy, was carried out. Al patients received low temperature coblation of adenoid and dissection tonsilectomy. After a folowing﹣up period over one year, these children received the same assessment methods mentioned above.ResultsA significant improvement was observed according to compare the AHI, OAI, LSaO2by pre-operation and post-operation with a folowing﹣up period from 12 months to 24 months.Conclusion Low temperature coblaton of adenoid combining with dissection tonsilectomy is safe and effective in the treatment of OSAHS.%目的:探讨腺样体低温等离子消融术联合扁桃体摘除术治疗儿童OSAHS的疗效。方法回顾分析23例儿童OSAHS患者,经过PSG(多导睡眠图)和电子鼻咽喉镜检查确诊,主要病因为腺样体肥大和扁桃体肥大,治疗采用腺样体低温等离子消融联合扁桃体摘除术。术后随访1年以上,再次行PSG和电子鼻咽喉镜检查评估疗效。结果23例患儿术后随访12~24月,平均(18±5)个月,客观检查患儿术前术后平均AHI,OAI及LSaO2变化(P<0.01)。结论OSAHS儿童患者尤其是患腺样体肥大、扁桃体肥大者,行腺样体低温等离子消融术联合扁桃体摘除疗效极好,有效率达90%。

  7. Clinical analysis on the therapeutic effect of adenoid plasma ablation under nasal endoscope on children with snoring condition%鼻内镜下等离子切除腺样体治疗小儿鼾症的临床分析

    Institute of Scientific and Technical Information of China (English)

    陈登胜

    2014-01-01

    Objective To observe the therapeutic effect of adenoid plasma ablation under nasal endoscope on children with snoring condition based on a clinical trial. Methods A retrospective analysis was made among 80 children cases with snoring condition, treated in our Hospital from January 2010 to December 2013 by plasma ablation to remove their hypertrophied adenoid, with their clinical data carefully analyzed to sum up our clinical experience with such a condition. Results All these patients were recovered well, with such symptoms disappeared among them as snoring and mouth breathing and without obvious complications happened. The averaged staying period in hospital was 5.5 days after the operation. As shown by the end of followed up period lasted for 2 to 6 months, nasopharyngeal mucosa was recovered well in an appearance of smooth, with no adhesion and no residual adenoidal tissue present among all these cases. Conclusions Nasal endoscope guided adenoidectomy with plasma ablation can created a much clearer operating field, with such advantages as less bleeding during operation, safer and better therapeutic effect as compared with the conventional procedures.%目的:观察鼻内镜下低温等离子切除腺样体治疗小儿鼾症的临床疗效。方法回顾性分析分析我科2010年1月至2013年12月在鼻内镜下应用等离子刀切除肥大腺样体治疗小儿鼾症80例的临床资料,总结临床经验与体会。结果全部病例术后恢复良好,睡眠打鼾和张口呼吸症状均消失,无明显并发症,平均住院5.5天。术后随访2~6个月,全部病例鼻咽黏膜光滑无粘连,无腺样体残留。结论鼻内镜引导下行腺样体等离子切除术术野清晰,出血少,安全性高,效果良好。

  8. Application of Low-dose CT Scanning in the Evaluation of Upper Airway Obstruction in Children with Adenoid Hypertrophy%低剂量CT对儿童腺样体肥大上气道阻塞的客观评价

    Institute of Scientific and Technical Information of China (English)

    蒋山姗; 徐嵩; 丁琼; 郭建东; 刘西; 唐伟华

    2014-01-01

    目的:研究低剂量CT三维重建技术在儿童腺样体肥大所致上气道顺应性改变的客观评估中的临床应用价值。方法19例腺样体肥大患儿接受CT低剂量扫描和症状计分表调查,与17例正常儿童的CT低剂量扫描后三维测量指标进行对照。结果腺样体肥大组患儿单位鼻咽腔容积(rNPV)及鼻咽气道最狭窄处面积比值(rNPA)与对照组比较差异均有统计学意义(rNPV值P<0.01、rNPA值P<0.05);rNPA与症状严重程度呈负相关(r=-0.659,P<0.01), rNPV值与症状计分无明显相关(P>0.05)。结论低剂量CT三维重建技术可用于腺样体肥大所致儿童上气道阻塞的客观定量评估。在解释测量结果与主观症状关系时rNPA应作为主要参考指标。%Objective To evaluate the clinical application value of Low-dose CT scanning and three-dimensional reconstruction method in the objective evaluation of upper airway obstruction caused by adenoid hypertrophy in children. Methods nineteen patients with adenoid hypertrophy were examined with low-dose CT and questionnaire. The measured values of 3D reconstruction were compared with those of 17 normal children. Results There were significant differences between the study group and the control group in rNPV(P0.05). Conclusion Low-dose CT scanning with 3D reconstruction method was an objective and quantitative method for the evaluation of upper airway in children with adenoid hypertrophy. The relationship of the measured values and subjective symptoms can be evaluated by rNPA.

  9. 孟鲁司特联合鼻内激素治疗儿童腺样体肥大的临床观察%Clinical efficacy of combined treatment with montelukast and intranasal steroid for chronic adenoid hypertrophy in children

    Institute of Scientific and Technical Information of China (English)

    陈超; 刘大波; 刘少峰; 仇书要

    2013-01-01

    Objectives To observe the clinical efficacy of combined treatment with montelukast and intranasal steroid for chronic adenoid hypertrophy in children. Methods 47 children with chronic adenoid hypertrophy were selected and ran-domly divided into drug combination group (n=23) treated with montelukast combined with intranasal steroids for two months and control group (n=24) treated with intranasal steroids only for two months. Clinical efficacy was compared between two groups by clinical score and the result of fibronasopharyngoscopy. Results The clinical scores were 0 (0, 1.0) and 0(0, 0) at 2 weeks and 2 months after treatment in combination group, and 1.0 (1.0, 1.0) and 0 (0, 1.0) in control group. There were sig-nificant differences between two groups (Z=2.404, P<0.05;Z=2.069, P<0.05). Conclusions The clinical efficacy of combined treatment with Montelukast and intranasal steroid is better than that of treatment with intranasal steroid only in children with chronic adenoid hypertrophy.%  目的观察孟鲁司特联合鼻内激素治疗儿童腺样体肥大的短期疗效。方法选取腺样体肥大患儿47例,随机分成2组。联合用药组23例,采用孟鲁司特与鼻内激素联合治疗;对照组24例,单用鼻内激素治疗;连续治疗2个月。根据纤维鼻咽镜检查和改进的Bitar临床评分方法比较两组疗效。结果联合用药组治疗2周和2个月的临床评分分别为0(0,1.0);0(0,0),优于对照组的临床评分1.0(1.0,1.0);0(0,1.0),差异具有统计学意义(Z=2.404、2.069,P均<0.05)。结论孟鲁司特联合鼻内激素治疗腺样体肥大的疗效优于单纯使用鼻内激素。

  10. Clinicopathological Features and Immunohistochemical Phenotypes of Adenoid Cystic Carcinoma of the Uterine Cervix%宫颈腺样囊性癌临床病理特征及免疫组织化学表型

    Institute of Scientific and Technical Information of China (English)

    师晓华; 武莎菲; 凌庆; 霍真; 梁智勇

    2015-01-01

    目的:探讨宫颈腺样囊性癌(adenoid cystic carcinoma, ACC)临床病理及免疫组化特征。方法收集北京协和医院2003年1月至2013年12月病理数据库及会诊数据库中诊断为宫颈腺样囊性癌病例共4例;并采用免疫组化方法对石蜡组织标本进行检测,总结其临床病理特征、治疗及预后。结果4例宫颈腺样囊性癌患者平均年龄61.5岁,多为绝经后妇女(3/4),就诊主要症状为阴道流血(3/4),肿瘤类型多为外生性肿物(3/4)。病理学特征方面,3例患者表现为宫颈腺样囊性癌合并侵袭性鳞癌,1例为宫颈腺样囊性癌单一组分;腺样囊性癌的主要生长方式为筛状;免疫组织化学表达方式支持其导管腺上皮及肌上皮两种组成成分: CK7在导管腺上皮中阳性表达, P63、 SMA在肌上皮中阳性表达;腺样囊性癌特征性标志物C-MYB在所有病例中均强阳性表达。3例患者完全切除子宫,1例患者行宫颈锥切,临床分期均为Ⅰ期;术后均行放射治疗,2例患者同时行化学治疗;4例患者平均随访时间为21.25个月,均为无病生存状态。结论宫颈腺样囊性癌是一种罕见的特殊类型腺癌,常合并其他类型的宫颈肿瘤,免疫组化表型与其他部位的腺样囊性癌相同,但预后相对较差,术后可辅以放疗及化疗,早期发现并治疗可以提高患者生存率。%Objective To investigate the clinicopathological and immunohistochemical features of adenoid cystic carcinoma ( ACC) of the uterine cervix .Methods Four cases who were diagnozed with ACC of the uter-ine cervix in the period from January 2003 to December 2013 were collected from the pathological databank and consultation database of Peking Union Medical Hospital .Immunohistochemical examination was conducted on the formalin-fixed, paraffin-embedded tissue specimens from the 4 patients.Clinical information, pathological fea

  11. Plasma Radiofrequency Treatment at Low Temperature Under Endoscope Clinical Research of Adenoid Hypertrophy in Children%鼻内镜下低温等离子消融术治疗儿童腺样体肥大的临床研究

    Institute of Scientific and Technical Information of China (English)

    杨国勇; 李亶; 温太佩

    2015-01-01

    目的研究分析采用鼻内镜下低温等离子消融术治疗儿童腺样体肥大的临床效果以及不良反应情况。方法采用回顾性分析的方法,分析了我院在2012年3月~2014年3月收治的108例儿童腺样体肥大患者的临床资料,根据治疗方法的不同,将本组患者随机分成对照组和实验组,每组各54例,对照组患者采用经口咽刮除腺样体的传统手术方法治疗,实验组患者则采用鼻内镜下低温等离子消融术治疗。分析比较两组患者的临床治疗效果。结果研究结果表明采用鼻内镜下低温等离子消融术治疗儿童腺样体肥大有效率明显高于传统的手术方法。结论对于儿童腺样体肥大,采用鼻内镜下低温等离子消融术治疗效果好,能够明显提高患者的临床治疗有效率,且不良反应少,安全可靠。%Objective To analyze the clinical ef ects and adverse reactions for adenoid hypertrophy in children using plasma radiofrequency treatment at low temperature under endoscope.Methods We analyzed the clinical data of 108 cases of adenoid hypertrophy children in our hospital from March 2012 to March 2012.According to the dif erent method of treatment,this group of patients were randomly divided into control group and experimental group,each group with 54 cases.The control group were treated with traditional surgery method by the oropharynx shaving adenoidectomy,while the experimental group patients used plasma radiofrequency treatment at low temperature under endoscope.Analyze and compare the clinical treatment ef ect of two groups of patients.Results The results indicate that using plasma radiofrequency treatment at low temperature under endoscope in children adenoid hypertrophy were significantly higher than the ef icient traditional surgical method. Conclusion The ef ect of using plasma radiofrequency treatment at low temperature under endoscope adenoid hypertrophy in children is good,it can

  12. 鼻内镜下两种不同手术方式治疗儿童腺样体肥大78例疗效比较%Comparison of curative effect of two different operation ways under nasal endoscopy in the treatment of 78 children with adenoidal hypertrophy

    Institute of Scientific and Technical Information of China (English)

    赵九洲; 林曾萍; 邱书奇

    2014-01-01

    目的:探讨鼻内镜下两种不同手术方式治疗儿童腺样体肥大的临床效果。方法将我院2011年3月~2013年3月收治的78例儿童腺样体肥大的患者随机分为两组,A组采用鼻内镜下电动切割器行腺样体切除术,B组采用鼻内镜下等离子ENT射频消融系统对腺样体行低温射频消融切除术。比较两组患儿术后发热、出血、鼻腔恢复正常通气时间以及并发症发生情况。结果两组患儿经治疗后临床症状完全缓解,B组在术后发热、出血、鼻腔恢复正常通气时间以及并发症等方面均优于A组,差异有统计学意义(P<0.05)。结论鼻内镜下儿童腺样体肥大的患者行低温等离子射频消融切除术较行电动切割器腺样体切除术损伤小、出血少、预后好,值得临床上广泛应用。%Objective To explore the clinical effect of two different operation ways under nasal endoscopy in the treatment of children with adenoidal hypertrophy. Methods 78 children with adenoidal hypertrophy were collected in our hospital during March 2011 to March 2013, and randomly divided into the two groups, the group A was treated with the adenoidectomy by electric cutter under nasal endoscopy, the group B was treated with the adenoidal low-temperature radiofrequency ablation excision by ENT plasma radiofrequency ablation system under nasal endoscopy. The postoperative fever, bleeding, nasal normal ventilation time and incidence of complications of children in the two groups were compared. Results The clinical symptoms of children in the two groups were completely relieved after treatment, the postoperative fever, bleeding, nasal normal ventilation time and complications in the group B were better than those in the group A, there were statistically significant differences(P<0.05). Conclusion Compared with adenoidectomy by electric cutter, the low-temperature plasma radiofrequency ablation excision for children with adenoidal

  13. 鼻内镜下两种入路电动吸切器对Ⅲ~Ⅳ度腺样体肥大患儿手术切除的比较%A comparative study of therapeutic effect on adenoidal hypertrophy at Ⅲ~Ⅳ degrees removed under nasal endoscope via two different approaches for powered debrider

    Institute of Scientific and Technical Information of China (English)

    方均平

    2015-01-01

    Objective To investigate the surgical effect on adenoidal hypertrophy at Ⅲ~Ⅳ degrees removed under nasal endoscope via two different approaches for powered debrider in a comparative way. Methods Sixty children cases with Ⅲ~Ⅳ degree of adenoidal hypertrophy were included in this study, treated in our Hospital from January 2012 to August 2014. They were operated on under nasal endoscope with powered debrider to remove the hypertrophied adenoid, either via transnasal approach (nasal approaching group, NAG) or via transoral approach (oral approaching group, OAG), with 30 cases in each group. A period of postoperative following up lasted for 6 months was carried out among them to compare the differences in therapeutic effect and incidence of surgery related complications between these two groups of children. Results There was no statistical significance in the differences of operating time (t=0.537, P=0.296), content of blood lost (t=-0.860, P=0.196) and postoperative headache within the first week following the surgery (t=0.728, P=0.524) between the two groups, while the incidences of mucosal injury occurred during the operation (X2=10.153, P=0.001), nasal blockage feeling after the operation (X2=9.017, P=0.003) and postoperative soft palate edema (X2=12.342, P=0.001) were significantly higher in NAG than that in OAG. Conclusions Operation via transoral approach holds such advantage as to control the performing process easier but slightly difficult to just the depth of ablation, while operation via transnasal approach is simpler to perform but followed relatively higher incidences of postoperative nasal adhesion and adenoidal residue following the surgery.%目的 比较鼻内镜下不同入路电动吸切器切除Ⅲ~Ⅳ度肥大腺样体的手术效果. 方法 2012年1月至2013年8月在我院拟行鼻内镜下手术治疗的Ⅲ~Ⅳ度腺样体肥大患儿60例,分别经鼻入路(鼻入路组)和经口入路(口入路组)行电动吸

  14. 舌下含服粉尘螨滴剂对小儿过敏性鼻炎伴腺样体肥大的疗效%Specific Sublingual Immunotherapy with Dermatophagoides Farinae Drops for Allergic Rhinitis Complicated by Adenoid Hypertrophy in Children

    Institute of Scientific and Technical Information of China (English)

    吕显林; 岳耀光; 张永强; 朱绪亮; 张俊; 郭军; 黄丽芳; 梁仕才

    2015-01-01

    ABSTRACT:Objective To investigate the curative effects of specific sublingual immunotherapy with Dermatophagoides farinae drops on allergic rhinitis complicated by adenoid hypertrophy in children.Methods Ninety children with allergic rhinitis and adenoid hypertrophy randomly re-ceived sublingual immunotherapy with Dermatophagoides farinae drops(group A,n=30),conven-tional treatment with anti-allergic drugs(group B,n=30),or their combination(group C,n=30). Nasal symptoms(nasal congestion,nasal itching,sneezing,runny nose,etc.)and snoring symp-toms(labored breathing,waking up repeatedly,snoring,mouth breathing,etc.)were evaluated u-sing the visual analogue scale(VAS)before and after treatment for 6 months.The maximum thickness of adenoid/anterior-posterior diameter of nasopharyngeal air space (A/N)ratio was measured by X-ray absorptiometry and computed tomography.Results Before treatment,there were no significant differences among the three groups in VAS scores of nasal symptoms and sno-ring symptoms,as well as in A/N ratio(P >0.05).After treatment for 6 months,VAS scores of nasal symptoms and snoring symptoms and A/N ratio obviously reduced in all the three groups (P 0.05).Compared with group B,VAS scores of snoring symp-toms and A/N ratio increased in group A but decreased in group C(P <0.05).Conclusion There is a close relationship between allergic rhinitis and adenoid hypertrophy in children.Specific sub-lingual immunotherapy not only improves nasal allergic symptoms,but also relieves snoring symptoms through reducing adenoid volume.Therefore,specific sublingual immunotherapy pro-vides a new method for non-surgical treatment of allergic rhinitis complicated by adenoid hyper-trophy.%目的:探讨儿童过敏性鼻炎伴腺样体肥大患儿采用舌下含服粉尘螨滴剂治疗的疗效。方法将90例过敏性鼻炎合并腺样体肥大的患儿按随机数字表法分为 A、B、C 3组,每组30例。A 组给予舌下含服粉尘螨滴剂治疗;B 组

  15. 玉屏风颗粒联合鼻用激素治疗儿童中重度腺样体肥大的临床观察%A combined therapy with Yupinfeng Granule and nasal steroids for the treatment of moderate to severe adenoid hypertrophy among children

    Institute of Scientific and Technical Information of China (English)

    吴婷; 田道法

    2015-01-01

    目的:总结玉屏风颗粒联合鼻用激素治疗儿童中重度腺样体肥大的临床体会。方法拒绝接受手术治疗的腺样体肥大患儿30例,依据鼻咽侧位片A/N比值评判腺样体大小,包括中度肥大17例,重度肥大13例,予以玉屏风颗粒口服,鼻用激素丙酸氟替卡松或曲安奈德鼻喷剂喷鼻,连续治疗3月。观察比较治疗前后患儿相关症状变化及腺样体体积改变,评价治疗效果,并结合文献复习探讨其病机特点,分析临床疗效。结果经连续3月以上治疗,中度腺样体肥大患儿显效11例(11/17,64.71%),有效3例(3/17,17.64%),总有效率(14/17,82.35%);重度腺样体肥大患儿显效6例(6/13,46.15%),有效4例(4/13,30.76%),总有效率(10/13,76.92%)。经半年以上随访,多数患儿基本维持有效现状,但有5例因病情反复而接受手术治疗(5/24,20.83%)。结论对于中度以及拒绝手术治疗的重度腺样体肥大患儿,可以考虑采用玉屏风颗粒联合鼻用激素疗法治疗观察3~6月,仍无症状改善者,则宜积极考虑手术疗法。%Objective To observe the therapeutic effect of a combined therapy with Yupingfeng Granule (YPFG) and nasal steroids(NS) on moderate to severe adenoid hypertrophy among children. Methods Included in this study were 30 children cases with adenoid hypertrophy diagnosed on the basis of A/N ratio determination according to a lateral nasopharyngeal X-ray photograph, with 17 at moderate degree and 13 at severe degree. All these cases were given a combined therapy with YPFG orally taken and NS spraying into nasal cavity lasted for 3 months consecutively. Then, changes in symptoms and adenoidal volume of these cases were observed in a comparative way with that of pre-treatment to evaluate therapeutic effect on the lesion, supplemented with a literature review to explore associated pathogenesis with such a condition in terms of

  16. EGFR、PCNA、LN、IV型胶原在SACC中的表达及临床意义%The clinical significance of EGFR,PCNA,LN and type IV collagen expression in salivary adenoid cystic carcinoma

    Institute of Scientific and Technical Information of China (English)

    杜贵霞; 张凡; 霍秀英; 李立恒; 李瑞平; 刘博; 张九鸿; 白睿; 赵秀芳

    2014-01-01

    Objective:To investigate the clinical significance of epidermal growth factor receptor(EGFR),proliferating cell nuclear antigen(PCNA),laminin(LN)and type IV collagen expression in salivary adenoid cystic carcinoma(SACC).Methods:EGFR gene in 78 cases of SACC with complete clinical data was detected by fluorescence in situ hybridization(FISH)technique,the expression of EGFR,PCNA,LN and type IV collagen protein was detected by immunohistochemistry technique(IHC),their correlation with the clin-icopathological parameters was analysed by SPSS 13.00 software.Results:EGFR gene amplification levels(69.2%)was positively related to the ratio of EGFR protein positive expression(7 1 .8%),the expression of EGFR,PCNA,LN and type IV collagen was posi-tively related to the clinical pathological parameters(P<0.05).There was a positive correlation between EGFR and PCNA expression (P<0.05),a negative correlation between LN protein and type IV collagen protein expression(P<0.05).Conclusion:EGFR gene is amplified in SACC.EGFR,PCNA,LN and type IV collagen take part in the occurrence and development of SACC.%目的:探讨表皮生长因子受体(EGFR)、增殖细胞核抗原(PCNA)、层黏连蛋白(LN)和IV型胶原蛋白在唾液腺腺样囊性癌(SACC)中的表达及临床意义。方法:选取临床病例资料齐全的SACC 78例,用荧光原位杂交技术检测EGFR基因表达,免疫组织化学技术检测 EGFR、PCNA、LN和Ⅳ型胶原蛋白的表达,分析其与临床病理参数的相关性。结果:SACC中EG-FR基因扩增率(69.2%)与蛋白的阳性表达率(71.8%)存在明显正相关(P<0.05),且EGFR、PCNA、LN、Ⅳ型胶原蛋白表达与临床病理参数密切相关。EGFR、PCNA表达水平间存在明显正相关(P<0.05);LN蛋白、Ⅳ型胶原表达水平间存在明显负相关(P<0.05)。结论:EGFR基因在SACC中明显扩增,EGFR、PCNA、LN、Ⅳ型胶原蛋白共同参与SACC发生、发展。

  17. Systematic reviews on efficacy and safety of beclomethosone nasal spray in the treatment of chronic adenoid hypertrophy in children%倍氯米松鼻喷剂治疗儿童腺样体肥大的系统评价

    Institute of Scientific and Technical Information of China (English)

    米姣平; 樊韵平; 王静清; 夏文彤

    2010-01-01

    Objective To systematically review the efficacy and safety of beclomethosone nasal spray in the treatment of chronic adenoid hypertrophy in children. Methods We computerized searches of the Cochrane Central Register of ControUed Trials (CENTRAL) (issue1,009), MEDLINE (1950 to August 2008) ,EMbase (1984 to August 2008), CNKI (1994 to September 2008), and VIP (1989 to August 2008), WANFANG DATA, Annual Review-s and Elsevier Science. Also the reference lists of all papers were identified for further trials. All searches were initially performed in May 2007 and updated in April 2009. Randomized controlled trials (RCT) and quasi-RCTs were identified and analyzed according to the Cochrane Handbook for Systematic Reviews of Interventions. Results Three RCT were included. Meta-analysis was not performed due to heterogeneity and the data were summarized in a narrative formal The trials showed that higher doses of beclomethasone (336 μg/d, 400 μg/d) might improve the nasal obstruction symptoms and reduce adenoid size in children with adenoid hypertrophy. Conclusions Higher and subsequently half doses of beclomethasone (336 g/d, 400 g/d) can improve the nasal obstruction symptoms in children with adenoid hypertrophy. The improvement appears to be associated with a reduction of adenoid size. Beacuse of a lack of the RCT, further studies are required to support the use of beclomethasone as a first-line approach for these children.%目的 系统评价局部使用倍氯米松气雾剂对儿童腺样体肥大的有效性、安全性.方法 计算机检索临床随机对照试验资料库Cochrane图书馆、MEDLINE、EMbase、维普中文期刊数据库(VIP)、万方学位论文数据库、中国期刊全文数据库(CNKI)、中国医疗健康年库等,并辅以手工检索相关会议论文集、药厂资料及所有检索到的文献的参考文献.检索截至2009年1月.收集倍氯米松鼻喷雾剂对腺样体肥大治疗作用的随机对照试验(RCT)及半随机对照

  18. Expression and Clinical Significance of MMP-9 and CD147 in Salivary Adenoid Cystic Carcinoma%MMP-9、CD147在涎腺腺样囊性癌中的表达及临床意义

    Institute of Scientific and Technical Information of China (English)

    任洁琼; 赵艳琴; 范熙明; 南欣荣

    2012-01-01

    目的:联合检测人涎腺腺样囊性癌组织中MMP-9、CD147的表达并分析其相关性,探讨其与临床病理参数间的关系,为腺样囊性癌的临床治疗和预后判断提供理论依据.方法:选择山西医科大学第一医院病理科存档的腺样囊性癌组织标本21例(癌组),正常涎腺组织6例(对照组).21例腺样囊性癌分别依据临床分期、有无侵犯神经进行分组.运用免疫组织化学PV-9000二步法检测MMP-9、CD147,结果用SPSS 13.0软件分析.结果:MMP-9及CD147在腺样囊性癌组中的阳性表达率(分别为76.2%和81.0%)明显高于在对照组中的阳性表达率(分别为16.7%和16.7%),差异有统计学意义(分别为P<0.05和P<0.01).Ⅲ+Ⅳ期腺样囊性癌病例MMP-9及CD147的阳性表达率(均为100.0%),明显高于Ⅰ+Ⅱ期病例(分别为44.4%和55.6%),差异有统计学意义(分别为P<0.01和P<0.05).有无侵犯神经的病例组间比较,MMP-9及CD147的表达差异没有统计学意义(P>0.05).MMP-9和CD147在腺样囊性癌组织中均呈阴性、弱阳性、阳性、强阳性表达者分别为4、5、7和3例,表达一致率为90.5%,Kappa值为0.870.结论:MMP-9和CD147均可作为反映腺样囊性癌细胞生物学行为的客观参考指标,其表达与临床分期密切相关,且二者之间的表达有正相关.%Objective: To investigate the expression of matrix metalloproteinase (MMP)-9 and CD147 in human salivary adenoid cystic carcinoma (SACC) tissues and their correlations. Methods: 21 cases of human SACC tissues and 6 cases of normal human salivary tissues were examined by immunohistochemical method. The relationship between the expression and clinical-pathological behaviors was also analyzed. Follow-up data were statistically analyzed. Results: The expression of MMP-9 and CD 147 in SACC tissues was higher than those in normal salivary tissues. Positive expression rate of MMP-9 and CD147 in SACC tissues was 76.2% and 81.0% respectively

  19. RhoA和Snail在涎腺腺样囊性癌中的表达及意义%Significance of RhoA and Snail expression in salivary adenoid cystic carcinoma

    Institute of Scientific and Technical Information of China (English)

    胡瑞利; 安峰; 林媛媛; 马赛; 郭博伟

    2015-01-01

    目的:探讨RhoA和Snail在涎腺腺样囊性癌(SACC)中的表达及其与癌症侵袭转移的关系。方法采用免疫组织化学方法检测RhoA和Snail在55例SACC(SACC组)与20例癌旁正常组织(对照组)中的表达情况,分析RhoA和Snail的表达与SACC临床病理特征的关系及其在SACC组织中表达的相关性。结果 SACC组的RhoA (69.1%vs 5.0%)和Snail(72.7%vs 10.0%)蛋白阳性表达率高于对照组(均P<0.05);有淋巴结转移者的RhoA和Snail阳性表达率高于无转移者,Ⅲ+Ⅳ期的RhoA和Snail阳性表达率高于Ⅰ+Ⅱ期者;实体型的RhoA阳性表达率高于筛孔型,实体型和管状型的Snail阳性表达率高于筛孔型(均P<0.05),而不同性别、年龄及肿瘤部位的RhoA和Snail阳性表达率差异无统计学意义;RhoA和Snail在SACC中的表达呈正相关(rs=0.414,P<0.001)。结论 RhoA和Snail蛋白可能通过RhoA/ROCK/PKD1/NF-κB/Snail信号传导通路联合作用促进了SACC的浸润和转移。%Objective To investigate the relationship of RhoA and Snail expressions, and the invasion and metastasis in salivary adenoid cystic carcinoma (SACC). Methods The expressions of RhoA protein and Snail protein in 55 samples of SACC (SACC group ) and 20 samples of para-carcinoma normal tissues(control group) were detected using immunohisto⁃chemical method. The relationship between RhoA protein and Snail protein expressions and clinical and pathological charac⁃teristics were analyzed. Results The positive expressions of RhoA protein (69.1% vs 5.0%) and Snail protein (72.7% vs 10.0%) were significantly higher in SACC group than those in control group (P < 0.05). The positive expression rates of RhoA protein and Snail protein were significantly higher in patients with lymph node metastasis than those in patients with⁃out lymph node metastasis. The positive expression rates of RhoA protein and Snail protein were significantly higher in pa⁃tients at

  20. Exploration of Value on Adenoid Hypertrophy Effects on the Growth of Development of Children and Operation Treatment%腺样体肥大对儿童生长发育的影响及手术治疗的价值探讨

    Institute of Scientific and Technical Information of China (English)

    王海瑞; 赵俊亭; 刘伟杰; 许波

    2014-01-01

    Objective To analyze the adenoid hypertrophy (AH) on the growth and development of children and explore the clinical value of operation treatment of adenoid hypertrophy. Methods 32 cases of children with AH treated in our hospital from 2012 January to 2012 December were selected as the research object, they were looked on as the study group (n=32); at the same time, 32 healthy children of the same period as the control group (n=32);comparative analysis research group, 1 years after operation, height, body mass and intelligence of control group and the study group were compared and analyzed. Results In the control group, height and body mass of both in the preoperative or postoperative 1 year was better than study group (P<0.05);1 years after surgery, the preoperative mental index were improved (P<0.05), the study group and the control group were only in verbal comprehension disadvantages (P<0.05). Conclusion Adenoid hypertrophy (AH) had a significant impact on the growth and development of children, the operation treatment of AH can effectively improve the adverse effect of AH on the growth and development of children.%目的:分析腺样体肥大(AH)对儿童生长发育的影响,探讨手术治疗腺样体肥大的临床价值。方法选择2012年1月至2012年12月于我院接受治疗的32例 AH 患儿作为研究对象,视为研究组(n=32);同时选择同时期的32例健康儿童作为对照组(n=32);对比分析研究组、对照组以及研究组术前与术后1年的身高、体质量和智力情况。结果对照组的身高和体质量无论是在术前还是在术后1年均优于研究组(P <0.05);术后1年,研究组较术前的各项智力指标均有改善(P <0.05),研究组与对照组仅在言语理解方面存在劣势(P<0.05)。结论腺样体肥大(AH)对儿童生长发育的影响显著,采用手术治疗 AH 能够有效改善 AH 对儿童生长发育的不利影响。

  1. Clinical effect of two different types of surgical procedures under nasal endoscope in the treatment of pediatric adenoidal hypertrophy%鼻内镜下两种不同手术方式治疗儿童腺样体肥大的临床效果

    Institute of Scientific and Technical Information of China (English)

    韦一; 曾莉

    2015-01-01

    目的:比较鼻内镜下两种不同手术方式治疗儿童腺样体肥大的临床效果。方法选取本院2012年6月~2014年9月收治的74例腺样体肥大患儿作为研究对象,随机分成实验组和对照组,各37例。对照组给予鼻内镜下腺样体切除术,实验组给予鼻内镜下低温射频消融切除术,比较两组的临床效果。结果实验组的总有效率为97.30豫,显著高于对照组的81.08豫,差异有显著统计学意义(P<0.05)。实验组的手术时间、鼻腔恢复至正常通气时间显著短于对照组,差异有统计学意义(P<0.05)。实验组的出血量显著少与对照组,差异有统计学意义(P<0.05)。实验组的并发症发生率显著低于对照组,差异有统计学意义(P<0.05)。结论鼻内镜下低温射频消融切除术治疗儿童腺样体肥大的临床效果优于电动切割器行腺样体切除术,值得临床推广应用。%Objective To compare the clinical effect of two different types of surgical procedures under nasal endo-scope in the treatment of pediatric adenoidal hypertrophy. Methods 74 children patients with adenoidal hypertrophy in our hospital from June 2012 to September 2014 were selected and randomly divided into the control group and the ex-periment group,37 cases in each group.The control group was given adenoidectomy under nasal endoscope,the experi-ment group was given low-temperature radiofrequency ablation and resection under nasal endoscope.The clinical effect of two groups was compared. Results The total effective rate in the experiment group was 97.30%,which was higher than 81.08%in the control group,with significant difference(P<0.05).The operation time,the time of nasal cavity ventila-tion recovery to normal in the experimental group was shorter than that in the control group,with significant difference (P<0.05).The amount of bleeding in the experiment group was less than that in the control group,with significant differ-ence(P<0

  2. Bacteremia during adenoidectomy: a comparison of suction diathermy adenoid ablation and adenoid curettage.

    LENUS (Irish Health Repository)

    Casserly, Paula

    2010-08-01

    Transient bacteremia is induced by adenoidectomy when the integrity of the nasopharyngeal membrane is broken. The aim of this study was to determine the incidence of bacteremia in patients undergoing adenoidectomy, to identify the causative organisms, and to compare the incidences of bacteremia between the two techniques suction diathermy and curettage.

  3. 体部伽玛刀治疗头颈部腺样囊性癌多发肺转移瘤临床观察%Clinical study of stereotactic gamma-ray body radiation therapy for patients with pulmonary metastases derived from adenoid cystic carcinoma of the head and neck

    Institute of Scientific and Technical Information of China (English)

    王逸君; 王颖杰; 常冬姝; 李宏奇; 李平; 王济东; 吴伟章; 康晓黎; 邵银剑

    2013-01-01

    Objective To evaluate the value of the stereotactic gamma-ray body radiation therapy for patients with pulmonary metastases derived from adenoid cystic carcinoma of the head and neck.Methods 15 patients with 137 lung metastases treated with stereotactic gamma-ray body radiation therapy were analyzed.The patients experienced one to five courses of stereotactic gamma-ray body radiation therapy.2 to 10 lesions were radiated in one treatment and the median number is 5.The daily radiation dose of 50 %isodose line covering metastatic lesions was from 3-5 Gy and 5 fractions per week.30-52 Gy total doses in the edge of 50 % isodose line were divided into 10-16 times.Results 58 (42.34 %) lesions completely disappeared,64 (46.72 %) lesions were assessed into partial responses,15 (10.94 %) stable disease and 0 progression disease.The total effective rate was 89.06 %.Local control rates of 1,3 and 5-year were all 100 %.The overall survival rates of 1 year,2-year,3-year,4-year and 5-year were 100 %,100 %,90.9 %,63.6 % and 31.8 %,respectively.Conclusion The stereotactic gamma-ray body radiation therapy is an effective and safe method in treatment with lung metastases from primary adenoid cystic adenocarcinoma of head and neck.%目的 观察体部伽玛刀治疗头颈部腺样囊性癌多发肺转移瘤的临床疗效.方法 对15例头颈部腺样囊性癌肺转移瘤患者共计137个病灶采用立体定向体部伽玛刀治疗.单次治疗病灶2~10灶,中位数5灶.以50%剂量线为处方剂量线,单次照射剂量3~5 Gy,中位数4Gy,1次/d,5次/周,10~16次.肿瘤边缘总剂量30~52 Gv,中位数40 Gy.结果 137个病灶中,完全缓解58灶(42.3%),部分缓解64灶(46.7%),稳定15灶(10.9%),进展0灶,总有效率为89.1%.治疗后1、2、3年局控率均为100.0%.治疗后1、2、3、4、5年生存率分别为100.0%、100.0%、90.9%、63.6%、31.8%.结论 体部伽玛刀治疗头颈部腺样囊腺癌多发肺转移

  4. Effects of Compound Radix Sophorae Flavescentis injection on proliferation, apoptosis and Caspase-3 expression in adenoid cystic carcinoma ACC-2 cells%复方苦参注射液对泪腺腺样囊性癌ACC-2细胞增殖、凋亡及Caspase-3蛋白表达的影响

    Institute of Scientific and Technical Information of China (English)

    石博; 徐慧

    2012-01-01

    目的 探讨复方苦参注射液对泪腺腺样囊性癌ACC-2细胞增殖、凋亡及Caspases-3蛋白表达的影响.方法 体外培养人泪腺腺样囊性癌ACC-2细胞,应用MTT法检测细胞增殖;Annexin V/PI双染色流式细胞仪检测细胞凋亡和细胞周期;ELISA法检测Caspases-3蛋白表达.结果 复方苦参注射液对ACC-2细胞的体外增殖具有抑制作用,量效关系显著,与对照组比较有统计学差异(P<0.01),半数抑制浓度(IC50)为0.84 g/ml.经流式细胞仪检测表明,复方苦参注射液能使ACC-2细胞G0-G1期逐渐增加,G2-M期和S期逐渐减少,并且随着剂量的增加,ACC-2细胞凋亡率明显增加(P<0.05或P<0.01).复方苦参注射液能增强ACC-2细胞Caspases-3蛋白的表达(P<0.05或P<0.01),并呈剂量依赖性.结论 复方苦参注射液能有效抑制人泪腺腺样囊性癌ACC-2细胞Caspases-3蛋白表达,诱导ACC-2细胞凋亡,抑制肿瘤细胞增殖.%Objective To investigate the effects of compound Radix Sophorae Flavescentis injection on proliferation, apoptosis and Caspase-3 expression in human adenoid cystic carcinoma ACC-2 cells. Methods ACC-2 cells were cultured in vitro. MTT assay was used to measure the cell proliferative effect. The Annexin V/PI double staining analysis by flow cytometry was used to evaluate apoptotic rate and the cell cycle. The expression of Caspases-3 protein was detected by enzyme-linked immunosorbent assay ( ELISA ). Results Compound Radix Sophorae Flavescentis injection could inhibit the proliferation of ACC-2 cells in vitro,and dose-effect relationship was significant P<0. 01 ). IC50 of ACC-2 was 0. 84 g/ml. The flow cytometry test indicated, compound Radix Sophorae Flavescentis injection could make ACC-2 cells Go-G, phase gradually increasing, G2-M period and S phase reduce gradually, and with the increase of the dose, ACC-2 cell apoptosis rate increased significantly ( P<0. 05 or P<0.01 ). Compound Radix Sophorae Flavescentis injection could enhance ACC-2

  5. Carcinoma adenóide cístico de traquéia: tratamento pela laringotráqueo-esofagectomia e traqueostomia mediastinal Adenoid cystic carcinoma of the trachea: treatment by removing the larynx, trachea, and esophagus, and mediastinal tracheostomy

    Directory of Open Access Journals (Sweden)

    Manoel Ximenes Netto

    1999-12-01

    Full Text Available Os autores descrevem o caso de uma paciente de 54 anos de idade com carcinoma adenóide cístico de traquéia ao nível da cricóide, na qual foi realizada ressecção extensa, incluindo a laringe, parte da traquéia e esôfago. A reconstrução do trato digestivo foi através do tubo gástrico e a via aérea pela construção de uma traqueostomia mediastinal. Cinco anos mais tarde foi removida uma recorrência tumoral cutânea no pescoço. Sete anos depois do procedimento original, foi notada nova recorrência no mediastino, que respondeu à irradiação. A paciente encontra-se muito bem atualmente, oito anos e cinco meses após o procedimento.The authors describe the case of a 54 year-old female with adenoid cystic carcinoma of the trachea at the cricoid level upon whom extensive surgical resection was performed, including the larynx, part of the trachea and esophagus. Reconstruction of the digestive tract was done by means of a gastric tube and the airway with a mediastinal tracheostomy. Five years after the original procedure there was a local cutaneous recurrence which was removed. Seven years later the disease recurred in the mediastinum, which responded to irradiation. The patient is alive and well eight years and five months after the operation.

  6. 鼻镜下经口动力系统与传统手术治疗儿童OSAHS的对比研究%Comparative Study of Obstructive Sleep Apnoea Syndrome Breathing in Children Treated with Dynamical Cutterbar via Nasal Endoscope and Rout Curettage of Adenoids

    Institute of Scientific and Technical Information of China (English)

    谷彬; 王东海

    2011-01-01

    目的 比较鼻内镜监视下经口动力系统和传统手术方式治疗儿童阻塞性呼吸睡眠暂停综合征的临床疗效及对心理行为的改善情况.方法 将370例患者随机分为传统手术组160例(A组),鼻内镜监视下经口动力系统组210例(B组),对经两种手术方法治疗的患儿术后的临床症状和心理行为异常等情况进行分析和比较.结果 A组术后平均随访14个月,B组平均随访16个月.两组手术后对患儿临床症状均有改善.B组在睡眠打鼾、鼻塞、鼻漏、听力、上课注意力不集中、多动等症状改善方面明显优于A组(P<0.05).结论 鼻内镜下经口动力系统腺样体切除及扁桃体部分切除术对儿童阻塞性呼吸睡眠暂停综合征的治疗效果明显优于传统手术方法.%Objective The aim of this study was to compare the clinical effectiveness and the improvement of the mentality and behavior of obstructive sleep apnoea syndrome breathing( OSAHS )in children of dynamical system cutterbar via nasal endoscope for adenoidectomy and part of tonsillectomy ( group B 210cases ) and rout curettage of adenoids( group A 160cases ). Methods Clinical date of 370 patients who had accepted the surgery therapy in two ways,were retrospectively analyzed. To compare their clinical symptoms and the improvement of the mentality and behavior of OSAHS in children. Results The post-operation patients of two groups have significantly different in the symptomatic improvement. It showed that group B had significantly greater improvements in aspects of Sleep snoring, nasal obstruction, rhinorrhea, hearing, inattention in class,and restlessness than that in group A. Conclusion Dynamical system cutterbar via nasal endoscope for adenoidectomy and part of tonsillectomy by mouth is the best way to cure OSAHS in children in present time.

  7. 地西他滨上调唾液腺腺样囊性癌细胞系细胞hMLH1的表达%Decitabine up-regulates the expression of hMLH1 gene in salivary adenoid cystic carcinoma cell lines

    Institute of Scientific and Technical Information of China (English)

    韩一凡; 李江; 王旭; 张春叶; 田臻

    2013-01-01

    目的:通过检测地西他滨(decitabine)对体外培养人唾液腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)细胞系细胞hMLH1的影响,探讨DNA甲基化转移酶抑制剂应用于SACC治疗的可行性及可能机制.方法:采用不同浓度的decitabine处理SACC细胞系SACC-83和SACC-LM细胞,观察细胞形态变化.选取5 μmol/L的decitabine处理细胞后,分别使用甲基化特异性PCR、蛋白免疫印迹法、流式细胞技术检测用药前、后hMLH1基因启动子甲基化状况、hMLH1蛋白表达和细胞周期、凋亡的变化.应用SPSS13.0软件包对数据进行独立样本t检验.结果:经decitabine处理后,SACC-83和SACC-LM细胞中hMLH1基因启动子甲基化水平降低,hMLH1蛋白表达水平分别升高1.582倍和1.977倍(P<0.05).用药后G0/G1期细胞比例显著减少,S期细胞比例显著增加(P<0.05),2种细胞系细胞晚期凋亡比例显著增加,差别有统计学意义(P<0.05).结论:Decitabine可通过改变hMLH1基因启动子甲基化水平,上调蛋白表达;使SACC细胞阻滞于S期,Decitabine有可能作为SACC化疗药物或与顺铂联合使用,增强顺铂的效果.

  8. 唾液腺腺样囊性癌中RASSF1A表达及与启动子甲基化之间的关系%The relationship between RASSF1A expression and promoter methylation in salivary adenoid cystic carcinoma

    Institute of Scientific and Technical Information of China (English)

    李蕾; 夏荣辉; 张春叶; 李江

    2014-01-01

    目的:研究唾液腺腺样囊性癌(adenoid cystic carcinoma,ACC)中RASSF1A表达及其与启动子区甲基化之间的关系.方法:收集167例原发性唾液腺ACC,亚硫酸盐测序聚合酶链反应(bisulfite sequencing polymerase chain reaction,BSP)和甲基化特异性聚合酶链反应(methylation-specific polymerase chain reaction,MSP)方法检测RASSF1A基因启动子区甲基化状况,免疫组织化学方法检测RASSF1A蛋白表达情况.去甲基化药物decitabine处理ACC细胞系SACC-83后,检测处理前、后RASSF1A基因甲基化及表达情况.应用SPSS 18.0软件包对数据进行统计学分析.结果:59/167(35.3%)例病例中检测到RASSF1A基因启动子区甲基化.101/167(60.5%)例病例中RASSF1A蛋白呈低或不表达,66/167(39.5)病例中RASSF1A蛋白呈高表达.存在RASSF1A基因甲基化组,RASSF1A蛋白表达显著低于不存在甲基化组(P=0.012).去甲基化药物decitabine处理ACC细胞系后,RASSF1A mRNA及蛋白水平表达均升高.结论:唾液腺ACC中,启动子区甲基化是RASSF1A基因失活的主要原因,可作为该肿瘤的潜在治疗靶点.

  9. 埃克替尼通过p38-MAPK信号通路对涎腺腺样囊性癌ACC-M细胞的凋亡诱导作用%Induction effect of icotinib on apoptosis of salivary adenoid cystic carcinoma ACC-M cells through p38-MAPK pathway

    Institute of Scientific and Technical Information of China (English)

    杨彩玲; 张景航; 张应花; 任铭新; 刘进忠; 崔卫刚

    2014-01-01

    目的:探讨埃克替尼对人涎腺腺样囊性癌细胞 ACC-M凋亡的影响,阐明埃克替尼对涎腺腺样囊性癌的治疗作用机制。方法:ACC-M细胞随机分为对照组,2、4、8μmo1·L-1埃克替尼组,促分裂原活化蛋白激酶(APK )抑制剂 SB203580(20μmol · L-1)组, SB203580(20μmol · L-1)+埃克替尼(4μmol·L-1)组。4 h后收集细胞,采用 MTT法检测各组 ACC-M细胞的生长抑制率,用 caspase-3活力检测试剂盒检测 ACC-M细胞的凋亡情况(即 caspase-3活力),采用 Western blotting法检测 p-p38-MAPK蛋白的表达水平。结果:与对照组比较,埃克替尼组 ACC-M细胞生长抑制率明显升高(P<0.05),caspase-3活力显著增强(P<0.05),p-p38-MAPK蛋白表达水平增加(P<0.05)。与4μmol·L-1埃克替尼组比较,SB203580+埃克替尼组 p-p38-MAPK蛋白表达水平明显降低(P<0.05),caspase-3活力显著降低(P<0.05)。结论:埃克替尼可通过上调 p-p38-MAPK信号的表达诱导 ACC-M细胞凋亡。%Objective To explore the influence of icotinib in the apoptosis of the human salivary adenoid cystic carcinoma cells ACC-M, and to clarify the mechanism of icotinib for the treatment of salivary adenoid cystic carcinoma.Methods The ACC-M cells were randomly divided into control group,2,4,8μmo1·L-1 icotinib groups,p38-MAPK inhibitor SB203580 (20μmol· L-1 )group,SB203580 (20 μmol· L-1 )+4μmo1 · L-1 icotinib group;the cells were collected 4 h after treatment.The viability of ACC-M cells was measured by MTT assay.The apoptosis of ACC-M cells was assessed by caspase-3 activity kit. The expression of p-p38-MAPK protein was determined by Western blotting analysis.Results Compared with control group,the inhibitory rates of growth of the ACC-M cells in icotinib groups were significantly decreased (P<0.05 ), and the activities of caspase-3 were increased (P<0.05),and the expression levels of p-p38-MAPK were

  10. Studies on therapeutic method of liver cancer(hapatocellular carcinome)by Holmium-166 radionuclide

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Tae; Yoo, H. S.; Kim, M. J.; Han, K. H.; Park, C. I. [Yonsei University Medical College, Seoul (Korea, Republic of)

    1997-07-01

    As the study of radioactive nuclide, Holmium-166 in the treatment of liver cancer(hepatocellular carcinoma), this study was performed under the base of animal experimental. Using dog liver, percutaneous injection of Ho-166 MAA or chitosan with premade dose was done under the ultrasound guidance. Continuously the same procedure as previous one was performed in the skin hapatoma, which was developed by the injection of hepatocellular carcinoma cell in the nude mouse, In case of injected normal liver of dog, imaging study including ultrasound, CT and MRI was done in order to evaluate effect of Ho-166 and pathologic reaction. The result showed well defined nectosis of normal liver as well as skin hepatoma. The area of nectosis is dependent on the dose of injected Ho-166. Generally, pathologic reaction is tissue coagulation nectosis, Ho-166 particles, fibrosis and hemorrhage. In the clinical study, 50 patients with hapatoma was selected for this study under the agreement of patient. Under ultrasound guidance percutaneous injection of Ho-166 Maa or chitosan to tumor was performed and follow-up study was extended from 6 to 12 month. The result showed that 64% of patient were completely treated. Overall, the effect of treatment could be obtained in 41 patient (82%) among 50 hepatoma patient. Conclusively Ho-166 is thought to be a compromising agent in the treatment of hepatocellular carcinoma and one of therapeutic modality, if it is established internally and world-wide. In the future, the popular percutaneous ethanol injection method will be replaced to this method. 19 refs., 1 tabs., 14 figs. (author)

  11. Non-surgical management of hepatocellular carcinoma; Prise en charge non chirurgicale du carcinome hepatocellulaire

    Energy Technology Data Exchange (ETDEWEB)

    Merle, P. [Service d' hepato-gastroenterologie, hopital de l' Hotel-Dieu, 69 - Lyon (France); Inserm U871 -Oncogenese hepatique et hepatites virales-, 69 - Lyon (France); IFR62 Lyon-Est, universite Lyon 1, 69 - Lyon (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, 69 - Pierre-Benite (France)

    2010-10-15

    Most of patients with hepatocellular carcinoma (HCC) cannot benefit from surgical therapies. Among non-surgical options, only radiofrequency can challenge surgery for small size tumours. Conformal radiotherapy is likely highly efficient on solitary tumours, but controlled studies are warranted to conclude. Other options are purely palliative. Trans-arterial hepatic chemo-embolization is the goal-standard for multifocal hepatocellular carcinoma and Sorafenib for hepatocellular carcinoma with portal vein invasion, leading to modest but significant benefit on survival rates. Yttrium-90 radio-embolization is under evaluation through controlled studies, and could be of major interest for multifocal hepatocellular carcinoma with or without portal venous invasion. (authors)

  12. Nasopharyngeal carcinomas: from biology to clinic; Les carcinomes du nasopharynx: de la biologie a la clinique

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, S.; Maingon, P. [Centre Georges-Francois-Leclerc, Dept. de Radiotherapie, 21 - Dijon (France); Keryer, C.; Busson, P. [Institut Gustave-Roussy, CNRS/UMR 8126, 94 - Villejuif (France)

    2005-02-15

    Nasopharyngeal carcinomas (NPC) are very different from other head and neck cancers because of their specific multi-factorial etiology and their geographic distribution. Epstein-Barr Virus (EBV) is implicated in onco-genesis of NPC in association with genetic alterations such as inactivation of the p16/Ink4, p19/ARF, RASSFI or Blu genes. Tumoral tissues include a very abundant characteristic lymphoid infiltrate. Inflammatory cytokines are produced by both malignant and infiltrating cells. There is no efficient immune response against the tumor. On the opposite, infiltrating lymphocytes might play a role in tumor development. Serological methods and detection of circulating viral DNA are expected to become useful for early detection of relapse and on a longer term for primary screening. NPC are often diagnosed at a late stage because patients may remain asymptomatic for a long time. Computed tomography (CT scan) and magnetic resonance imaging (MRI) are complementary for the initial evaluation. Positron emission tomography (PET) is efficient for the evaluation of treatment efficiency and detection of relapses. Treatment is based on radiotherapy and chemotherapy. Their optimal use needs to be evaluated by phase III trials but positive results have been obtained by concomitant association of radiotherapy and chemotherapy. Targeted therapies are being studied with strategies based on disruption of viral latency, use of replicative adeno-viruses or anti-tumor vaccination. (author)

  13. Small bowel obstruction caused by peritoneal immunoglobulin G4-related disease mimicking carcinomators: Case report

    Energy Technology Data Exchange (ETDEWEB)

    Coulier, Bruno; Montfort, Luc; Pierard, Frederic [Clinique St. Luc, Bouge (Belgium); Beniuga, Gabrique; Gielen, Lsabelle [Institute of Pathology and Genetics, Gosselies (Belgium)

    2014-02-15

    We hereby report a case of diffuse pelvic peritoneal involvement by immunoglobulin G4-related disease (IgG4-RD). Numerous pelvic masses and nodules showing delayed enhancement on enhanced abdominal CT were found to congregate in the pelvic organs of a 57-year-old female presenting with intestinal subocclusion. The differentiation between peritoneal IgG4-RD and pelvic peritoneal carcinomatosis was only made by histopathology and immunohistochemistry performed after surgical resection. Autoimmune pancreatitis represents the historical prototype of IgG4-RD, but the spectrum of manifestations involving various organs has expanded during the last decade. In this report, we shortly review this clinical entity.

  14. Sorafenib and radiotherapy association for hepatocellular carcinoma; Sorafenib et radiotherapie dans le carcinome hepatocellulaire

    Energy Technology Data Exchange (ETDEWEB)

    Girard, N. [Service de pneumologie, hopital Louis-Pradel, hospices Civils de Lyon, 28, avenue du Doyen-Jean-Lepine, 69500 Bron (France); UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Mornex, F. [UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Departement de radiotherapie-oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex (France)

    2011-02-15

    Conformal radiotherapy is a promising therapeutic strategy for hepatocellular carcinoma (HCC), producing local control rates above 90% within the radiation beam. However, survival after radiotherapy remains limited by the high frequency of intra- and extra-hepatic recurrences, which occurs in 40-50 and 20-30% of cases, respectively. Sorafenib (BAY43-9006, Nexavar; Bayer, West Haven, CT) is a small molecule inhibitor that demonstrated potent activity to target v-raf murine sarcoma oncogene homologue B1 (BRAF) and VEGFR tyrosine kinases. Sorafenib is the only drug that demonstrated effectiveness to increase overall survival in advanced or metastatic hepatocellular carcinoma. The rationale to combine radiotherapy with sorafenib is the following: (1) targeting RAS-RAF-MAPK and VEGFR signaling pathways, which are specifically activated after exposure to radiation, and responsible for radio-resistance phenomenon; (2) enhancing the oxygen effect through normalization of the surviving tumor vasculature; and (3) synchronization of the cell cycle. Sorafenib and radiotherapy represent complementary strategies, as radiotherapy may be useful to prolong the effect of sorafenib through control of the macroscopic disease, when sorafenib may target latent microscopic disease. Sorafenib and radiotherapy associations are thus based on a relevant biological and clinical rationale and are being evaluated in ongoing phase I-II trials. (authors)

  15. Irradiation of low rectal cancers; Radiotherapie des carcinomes du bas rectum

    Energy Technology Data Exchange (ETDEWEB)

    Ardiet, J.M.; Coquard, R.; Romestaing, P.; Fric, D.; Baron, M.H.; Rocher, F.P.; Sentenac, I.; Gerard, J.P. [Centre Hospitalier Lyon-Sud, 69 -Pierre-Benite (France)

    1994-12-31

    The low rectal cancers are treated by anorectal amputation and pose the problem of the sphincter conservation. Some authors extend the clinical definition to developed injuries until 12 cm from the anal margin. The rectal cancer is a frequent tumour which remains serious. When the tumour is low, the treatment consists in an anorectal amputation with a permanent colostomy. The radical non preserving surgery is the usual treatment of these injuries. Until 1960 the rectal adenocarcinoma was considered as a radioresistant tumour because of the impossibility to deliver an enough dose to the tumour by external radiotherapy. But other studies showed that those lesions were radiosensitive and often radiocurable. The medical treatments haven`t yet demonstrated their efficiency in the treatment of the rectal cancer. We`ll study the radiotherapy in the treatment of the low rectal cancer, solely radiotherapy, radiosurgical associations. 32 refs., 5 tabs.

  16. Late neurotoxicity after nasopharyngeal carcinoma treatment;Toxicite neurologique tardive apres traitement des carcinomes nasopharynges

    Energy Technology Data Exchange (ETDEWEB)

    Siala, W.; Mnejja, W.; Daoud, J. [Hopital Habib-Bourguiba, Service de Radiotherapie Carcinologique, Sfax (Tunisia); Khabir, A.; Boudawara, T. [Hopital Habib-Bourguiba, Service d' Anatomopathologie, Sfax (Tunisia); Ben Mahfoudh, K. [Hopital Habib-Bourguiba, Service de Radiologie, Sfax (Tunisia); Ghorbel, A. [Hopital Habib-Bourguiba, Service d' ORL, Sfax (Tunisia); Frikha, M. [Hopital Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia)

    2009-12-15

    Purpose A retrospective analysis of risk factors for late neurological toxicity after nasopharyngeal carcinoma radiotherapy. Patients and methods Between 1993 and 2004, 239 patients with non metastatic nasopharyngeal carcinoma were treated by radiotherapy associated or not to chemotherapy. Radiotherapy was delivered with two modalities: hyperfractionated for 82 patients and conventional fractionation for 157 patients. We evaluated the impact of tumour stage, age, gender, radiotherapy schedule and chemotherapy on neurological toxicity. Results After a mean follow-up of 107 months (35-176 months), 21 patients (8.8%) developed neurological complications, such as temporal necrosis in nine cases, brain stem necrosis in five cases, optics nerve atrophy in two cases and myelitis in one case. Five- and ten-year free of toxicity survival was 95 and 84% respectively. Young patients had greater risk of temporal necrosis, and hyperfractionated radiotherapy was associated with a significantly higher risk of neurological complications (14.6% vs 5.7%, p = 0.02). On multivariate analysis, hyperfractionation and age were insignificant. Conclusion Late neurological toxicity after radiotherapy for nasopharyngeal carcinoma was rare. Younger age and hyperfractionation were considered as risk factors of neurological toxicity in our study

  17. Change and Significance of Mean Platelet Volume in Children with Chronic Tonsillitis and Adenoid Hypertrophy%慢性扁桃体炎和腺样体肥大儿童外周血平均血小板体积变化及意义

    Institute of Scientific and Technical Information of China (English)

    郑海明

    2016-01-01

    Objective Chronic tonsillitis (CT)and adenoid hypertrophy (AH)is the most common cause of ob-structive sleep apnea hyponea syndrome(OSAHS).In the present study,we evaluated the relationship between mean platelet volume (MPV)and CT and AH which is the most frequent cause leading OSA in children.Methods A total of 40 children aged between 4 and 16,who underwent adenoidectomy or adenotonsillectomy with a diagnosis of AH and/or CT were recruited as operation group.38 healthy controls aged between 4 and 16 were employed as control group.Mean platelet volume (MPV)values,platelet count (PLT),white blood cell count (WBC)and hemoglobin (Hb)levels were recorded individually.Results It was found that MPV values in operation group were significantly lower than control group(P<0.001),whereas PLT in operation group was significantly higher than control group(P<0.001).There were no significant differences in WBC and HB values among groups.Conclusion OSAHS caused by CT-AH is associ-ated with low MPV values in childhood aged 4 to 1 6 .%目的:慢性扁桃体炎(CT)和腺样体肥大(AH)是引起阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的最常见原因。本研究探讨扁桃体和(或)腺样体切除后外周血平均血小板体积(MPV)变化及其意义。方法40例被诊断为腺样体肥大和(或)慢性扁桃体炎患儿全麻下行腺样体和(或)扁桃体切除术,设为手术组,年龄4到16岁。38例4到16健康岁儿童设为对照组。分别检测外周血平均血小板体积(MPV),血小板计数(PLT),白细胞计数(WBC)和血红蛋白(HB)水平。结果手术组 MPV水平明显低于对照组(P<0.001),手术组PLT明显高于对照组(P<0.001);手术组 WBC和 HB水平与对照组相比无统计学意义。结论4到16岁儿童由慢性扁桃体炎(CT)和腺样体肥大(AH)引起的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与外周血低水平血小板平均体积(MPV)有关。

  18. The relationship of enuresis nocturna and adenoid hypertrophy

    Directory of Open Access Journals (Sweden)

    Muhsin Balaban

    2016-07-01

    Full Text Available Objectives: This study was organized to assess the relationship of enuresis nocturna (EN and upper airway obstruction (UAO in children. Material and Methods: This study was multi-centrically and prospectively designed including 79 children who presented to a urology clinic with symptoms of EN between January 2013 and February 2014. Sixty-four age-matched children with no history of urological complaints were randomly recruited from children admitted to a pediatric clinic as a control group. All children and parents were asked to fill out a dysfunctional elimination syndrome (DES questionnaire and children were examined by an ear, nose and throat (ENT specialist to evaluate the UAO. Descriptive statistics, chisquare and Mann-Whitney-U tests were used to compare variables. Results: The mean ages of the 79 children (48 male, 31 female in the study group and the 64 children (41 male, 23 female in the control group were 10.14+/-3.38 and 9.17+/- 2.85, respectively. Family history of the study showed that 19% of the children’s mothers, 10% of the children’s fathers and 37% of the children’s siblings had experienced EN. There was a significant difference between the study and the control groups in terms of urge to urinate, bladder emptying, bowel symptoms and psychological stress. There was also a significant difference between rates of tonsillar hypertrophy and nasopharynx obstruction in the EN group (p = 0.009. Conclusion: In this study we found that half of the children with EN had tonsillar hypertrophy, which was significantly higher than in the control group. Further studies are needed to clarify the exact relationship between UAO and EN.

  19. 儿童腺样体肥大并发分泌性中耳炎与变应性鼻炎发病的相关性分析%Correlation analysis between the otitis media with effusion and allergic rhinitis in children with adenoidal hypertrophy

    Institute of Scientific and Technical Information of China (English)

    倪坤; 李晓艳

    2012-01-01

    %, respectively. There were significant differences among the groups (P<0.05). With the increase of the grades of blood flow signal, the maximum diameter of uterine cavity contents increased. There were significant differences(P<0.01). Conclusion Transrectal ultrasonography of uterine cavity is a valuable predictor for the outcome of medical abortion. For the patients received medical abortion with rich blood flow signal and big volume in uterine cavity contents, we should strengthen the monitoring and proceed a curettage actively.combined incidence of allergic rhinitis group of otitis media with effusion 51. 11%, higher than that in the control group to 32. 26%(χ2=5. 019,P<0. 05). Merger cases of allergic rhinitis, nasal steroid hormone group OME incidence of 12. 50%, significantly below the 51. 11% of the OME incidence of nasal steroid therapy group(χ2 = 23. 32,P<0. 01). Conclusion:In children with adenoidal hypertrophy groups associated with a higher prevalence of otitis media with effusion, allergic rhinitis is an important factor in secretory otitis media. The use of nasal steroid hormones can reduce the incidence of secretory otitis media and may have some effect on the treatment of otitis media. Specific efficacy assessment and treatment mechanism needs further study.

  20. Reirradiation by Cyberknife of head and neck carcinomas; Reirradiation par Cyberknife de carcinomes de la tete et du cou

    Energy Technology Data Exchange (ETDEWEB)

    Balajouza Kanoun, S.; Lacornirie, T.; Coche Dequeant, B.; Mirabel, X.; Lefebvre, J.L.; Lartigau, E. [Centre Oscar-Lambret, Univ. de Lille-2, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

    2007-11-15

    In spite of local treatment the local defeat is a problem in O.R.L. cancerology. It has been demonstrated that some recurrences or second cancers in beforehand irradiated area could be sterilized by a new irradiation of high dose after perfect definition of the volume to treat and the certainty that recurrence will be localized.Numerous works have allowed to underline that a part of patients, with an O.R.L. recurrence can be treated again with curative aim with survival rate about 20 to 20 % at three years. The objective of this study was to test with a phase two study, the validation of a stereotaxic type reirradiation by Cyberknife associated to Cetuximab. (N.C.)

  1. Squamous cell carcinoma complicating an hereditary epidermo-lysis bullosa; Carcinome spinocellulaire compliquant une epidermolyse bulleuse hereditaire

    Energy Technology Data Exchange (ETDEWEB)

    Mseddi, M.; Turki, H.; Marrekchi, S.; Abdelmaksoud, W.; Masmoudi, A.; Bouassida, S.; Zahaf, A. [Centre Hospitalier Universitaire Hedi Chaker, Service de Dermatologie, Sfax (Tunisia)

    2004-08-01

    The dystrophic form of hereditary epidermo-lysis bullosa is associated with an increased frequency of squamous cell carcinoma. We report a new case. An 18-year-old patient, carrying a Hallopeau Siemens hereditary epidermo-lysis bullosa, presented a subcutaneous nodular lesion, for 1 year that ulcerated and budded with inguinal lymphadenopathy. The histological study ted to the conclusion of a well differentiated squamous cell carcinoma. The patient was treated surgically. Tumor and metastatic lymph nodes were excised. A radiotherapy was decided but the postoperative course was fatal due to an infection and to a deterioration of her general condition. Squamous cell carcinoma frequently occurs on the cicatricial lesion of hereditary epidermo-lysis bullosa and usually affects males with recessive hereditary epidermo-lysis bullosa. Metastases are frequent, precocious and multiple. The treatment may be surgical. The particularities of our observation are the young age of patient and the localization. (author)

  2. Radio-embolization for hepatocellular carcinoma; Traitement des carcinomes hepatocellulaires par injection intra-arterielle de radio-isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Raoul, J.L. [Departement d' oncologie medicale, centre Eugene-Marquis, rue de la bataille Flandres-Dunkerque, CS 44229, 35042 Rennes cedex (France); Inserm U911, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France); Edeline, J.; Pracht, M.; Boucher, E. [Departement d' oncologie medicale, centre Eugene-Marquis, rue de la bataille Flandres-Dunkerque, CS 44229, 35042 Rennes cedex (France); Rolland, Y. [Departement d' imagerie medicale, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France); Garin, E. [Inserm U911, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France); Departement d' imagerie medicale, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France)

    2011-02-15

    Hepatocellular carcinoma is now a major public health concern. In intermediate stages (one third of hepatocellular carcinoma patients), chemo-embolization is the standard of care despite a poor tolerance and a moderate efficacy. Moreover, despite recent improvements, this technique seems in a dead end. Radio-embolization could be an excellent tool for such patients. Currently {sup 131}I-Lipiodol, {sup 188}Re-Lipiodol, {sup 90}Y-glass or resin microspheres are available. More recent and promising data come from microspheres, but phase II and III studies are needed before drawing any conclusion. In the future, the combination of radio-embolization with systemic chemotherapy or targeted agents (particularly anti-angiogenic drugs) seems very promising. (authors)

  3. [Changes in the blood indices of turkey poults experimentally infected with Eimeria adenoides].

    Science.gov (United States)

    Koĭnarski, V; Kamburov, P

    1985-01-01

    Studied were the changes in the values of sodium, potassium, chlorides, calcium, phosphorus, iron, and copper in the blood plasma as well as in that of hemoglobin, hematocrit, and the total count of blood cells in turkey poults experimentally infected with Eimeria adenoeides. The birds were divided into three groups of 40 each. The first and second were infected with various numbers of sporulated oocysts, while the third group was kept as a control one. It was found that Na, chlorides, Ca, P, and Fe were lowered, and K and Cu were increased over the same period. The total blood cell count and the hematocrit rose on the 4th and 5th day following infection, while they dropped on the 6th to the eighth day. The same was true of hemoglobin values.

  4. [Effect of anticoccidial preparations in the prevention of coccidiosis in turkeys caused by Eimeria adenoides].

    Science.gov (United States)

    Koĭnarski, V; Sherkov, Sh N

    1987-01-01

    Studied was the anticoccidial activity of the preparations monensin, salinomycin, lassalocid, lerbek, arpocox, and chimcoccid in the prevention of coccidiosis in turkey poults infected with Eimeria adenoeides. A total of 80 turkey poults were used. The prophylactic effect produced by the coccidiostatics was recorded as judged by the anticoccidial index, the liveweight at the beginning and at the end of the experiment, the amount of food intake, and the index of feed conversion. Best effect was produced by chimcoccid which was to be preferred to the other preparation in the prophylaxis of turkey cocidiosis. Comparatively good results were likewise obtained with the use of lerbek, followed by salinomycin and arpocox. Monensin and lassalocid ranked last.

  5. Sporadic Burkitt Lymphoma Presenting as Acute Pancreatitis, Concurrent Sinusitis, and Enlarged Adenoids

    OpenAIRE

    2016-01-01

    Pancreatitis and sinusitis as presentations of Burkitt lymphoma are uncommon and rarely described in children. We describe here the case of a child who presented with symptoms suggestive of sinusitis unresponsive to antibiotics, with subsequent development of abdominal symptoms due to pancreatitis. He was eventually diagnosed with Burkitt lymphoma.

  6. Ductal in situ carcinoma: is it ethical to consider the breast conserving?; Carcinome canalaire in situ: est-il ethique de considerer le traitement conservateur comme un standard?

    Energy Technology Data Exchange (ETDEWEB)

    Barillot, I. [Centre de Lutte Contre le Cancer Georges-Francois-Leclerc, Dept. de Radiotherapie, 21 - Dijon (France); Cutuli, B. [Polyclinique de Courlancy, Service de Radiotherapie-Cancerologie, 51 - Reims (France); Arnould, L. [Centre de Lutte Contre le Cancer Georges-Francois-Leclerc, Service d' Anatomie Pathologique, 21 - Dijon (France)

    2004-02-01

    The increasing incidence of DCIS during the past 20 years needs a continuous evaluation of the treatment strategies and a multidisciplinary decision process. The management of the DCIS remains a challenging issue in 2003. Mastectomy should still be considered as the reference treatment which is able to guarantee cure in almost all cases, whereas breast conserving surgery followed by radiation therapy is associated with 7-10% of local recurrence. However, the increasing knowledge of the predictive factors of the local recurrence allows to propose a conservative treatment strategy to a large amount of patients, without negative impact on their prognosis. This review presents the arguments that permit to justify, the reasoned choice of the different therapeutic options according to the clinico-pathological situations. (author)

  7. Choanal stenosis: a rare complication of radiotherapy for nasopharyngeal carcinoma; Stenose choanale post-radique: une complication rare de la radiotherapie des carcinomes nasopharynges

    Energy Technology Data Exchange (ETDEWEB)

    Bonfils, P.; Preobrajenski, N. de [Universite Rene-Descartes, Hopital Europeen Georges-Pompidou, Service d' ORL et de Chirurgie Cervicofaciale, Faculte de Medecine Paris-Descartes, 75 - Paris (France); Florent, A. [Cabinet d' ORL, 75 - Paris (France); Bensimon, J.L. [Cabinet de radiologie, 75 - Paris (France)

    2007-05-15

    Choanal stenosis is usually a congenital anomaly in children. Acquired choanal stenosis after radiotherapy for nasopharyngeal carcinoma is a very rare pathology; only two publications report seven cases in the literature. We describe the clinical history, preoperative evaluation, surgical treatment and outcome of a case of acquired choanal stenosis after radiotherapy. The patient, a 56-year-old woman, presented with a history of nasopharyngeal carcinoma (T2- NO-MO) one year before that had been successful treated with radiotherapy (68 Gy). At the end of radiotherapy, she complained of complete nasal obstruction, anosmia and hearing loss due to a bilateral serous otitis media. Bilateral complete choanal stenosis was confirmed by endoscopy and CT scan. Functional endoscopic surgery was performed, and nasal stents were left in place for 3 weeks. One year after, the patient have good airflow, and a patent nasopharynx without choanal stenosis. In conclusion, choanal stenosis is an unusual complication of radiotherapy that can be successfully treated with trans-nasal endoscopic resection. (authors)

  8. Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies; La chimioradiotherapie des carcinomes epidermoides des voies aerodigestives superieures: point sur les therapeutiques ciblees

    Energy Technology Data Exchange (ETDEWEB)

    Bozec, A. [Centre Antoine-Lacassagne, Dept. de Chirurgie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Thariat, J.; Bensadoun, R.J. [Centre Antoine-Lacassagne, Dept. de Radiotherapie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Milano, G. [Centre Antoine-Lacassagne, Unite d' Oncopharmacologie, Institut Universitaire de la Face et du Cou, 06 - Nice (France)

    2008-01-15

    Radiotherapy is an essential treatment for many patients with head and neck squamous cell carcinoma. Its association with molecular targeted therapies represents a real progress. Among the recent advances in the molecular targeted therapy of cancer, the applications centred on E.G.F.R. are currently the most promising and the most advanced at clinical level. Considering the set of therapeutic tools targeting E.G.F.R., there are at present two well-identified emerging categories of drugs with monoclonal antibodies, on the one hand, and tyrosine kinase inhibitors, on the other. In many preclinical studies, the combination of anti-E.G.F.R. drugs with irradiation has led to additive or supra-additive cytotoxic effects. Furthermore, anti-angiogenic agents have shown promising results in association with anti-E.G.F.R. drugs and radiotherapy. This research effort has recently produced encouraging clinical results in advanced head and neck cancer with combination of cetuximab (an anti-E.G.F.R. monoclonal antibody) with irradiation with a significant impact on patient survival. Active and efficient clinical research is currently ongoing to determine the place of molecular targeted therapies in the treatment of head and neck cancer, particularly in association with radiotherapy. (authors)

  9. Concomitant chemoradiotherapy in the treatment of the locally evolved larynx carcinoma; Chimioradiotherapie concomitante dans le traitement du carcinome du larynx localement evolue

    Energy Technology Data Exchange (ETDEWEB)

    Houjami, M.; Tarkouki, K.; Benjelloun, H.; Benchakroun, N.; Jouhadi, H.; Tawfiq, N.; Sahraoui, S.; Benider, A. [Centre d' Oncologie Ibn-Rochd, Casablanca (Morocco)

    2007-11-15

    The objective of this was to evaluate the contribution of concomitant chemoradiotherapy in the treatment of locally evolved larynx carcinomas. The results of the series are comparable to these ones got by several studies. The concomitant chemoradiotherapy tends to give a good local control with the advantage of organ conservation, at the price of an acceptable toxicity.The improvement of larynx cancer prognostic is through an early diagnosis but the fight against smoking constitutes the only means of prevention. (N.C.)

  10. Inoperable metastatic giant basal cell trunk carcinoma: radiotherapy can be useful; Carcinome basocellulaire geant du tronc metastatique inoperable: la radiotherapie peut etre utile

    Energy Technology Data Exchange (ETDEWEB)

    Mania, A.; Durando, X.; Lapeyre, M. [Centre Jean-Perrin, Clermont-Ferrand (France); Barthelemy, I. [CHU Estaing, Clermont-Ferrand (France)

    2011-10-15

    The authors evoke some characteristics of the basal cell carcinoma (slow evolution, local morbidity) and report and discuss the case of a giant basal cell trunk carcinoma, associated with several symptoms (pain, bleeding, anaemia), already metastatic at the moment of diagnosis, and locally treated by irradiation. Due to its size and expansion, this carcinoma was considered as inoperable. An external radiotherapy has been performed and resulted in a significant clinical tumour reduction. But the metastatic risk is high in such cases. Radiotherapy is then a therapeutic option for a local treatment with a durable efficiency. Short communication

  11. Radiotherapy of maxillary sinuses carcinoma: state of art; Radiotherapie des carcinomes des sinus maxillaires: l'etat de l'art

    Energy Technology Data Exchange (ETDEWEB)

    Chargari, C.; Bauduceau, O.; Vedrine, L.; Fayolle, M.; Ceccaldi, B. [Hopital d' Instruction des Armees Val-de-Grace, Service d' Oncologie Radiotherapie, 75 - Paris (France); Chargari, C.; Magne, N. [Institut Gustave-Roussy, Dept. de Radiotherapie, 94 - Villejuif (France); Haen, P. [Hopital d' Instruction des Armees Begin, Service de Chirurgie Maxillofaciale et Plastique de la Face, 94 - Vincennes (France); Conessa, C. [Hopital d' Instruction des Armees Val-de-Grace, Clinique d' Otorhinolaryngologie et de Chirurgie Cervicofaciale, 75 - Paris (France)

    2009-06-15

    Maxillary sinus carcinomas are rare malignancies of the face, characterized by high local relapsing rate. Modalities of treatment are without consensus and respective roles of radiation therapy and surgery remain controversial. As those malignancies are often diagnosed at locally advanced stage, radiation therapy may frequently be used for patients having unresectable advanced disease. Nevertheless, surgery remains treatment of choice for more localized malignancies, in association with systematic postoperative radiotherapy. For those patients whose prognosis remains pejorative, it is necessary to precise the role of radiotherapy in first intention for inoperable tumors, to define necessity for nodal treatment performing and evaluate the place of neo-adjuvant or concomitant chemotherapy in a multimodal strategy. (authors)

  12. Merkel cell carcinoma: Outcome and role of radiotherapy; Carcinome a cellules de Merkel: prise en charge et place de la radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Salvador Alonso, R.; Lahbabi, I.; Ben Hassel, M.; Boisselier, P.; Crevoisier, R. de [Centre Eugene-Marquis, Dept. de Radiotherapie, 35 - Rennes (France); Chaari, N. [Institut Gustave-Roussy, Dept. de Radiotherapie, 94 - Villejuif (France); Lesimple, T. [Centre Eugene-Marquis, Dept. d' Oncologie Medicale, 35 - Rennes (France); Chevrier, S. [Centre Hospitalier Prive de Saint-Gregoire, Dept. de Chirurgie Plastique, 35 - Saint-Gregoire (France)

    2008-09-15

    Merkel cell carcinoma (M.C.C.) are rare neuroendocrine malignant tumor of the skin, occurring in elderly patients. It affects primarily the sun-exposed areas of the skin, with approximately 50% of all tumors occurring in the face and neck and 40% in the extremities. Immunohistochemical markers (C.K.20+, C.K.7- and T.T.F.1-) are used to distinguish between M.C.C. and other tumors. M.C.C. have a tendency to rapid local progression, frequent spread to regional lymph nodes and distant metastases. Due to the rarity of the disease, the optimal treatment has not been fully defined. Localized stages (stages I and II) are treated by surgical excision of the primary tumor (with 2 to 3 cm margin) and lymphadenectomy in case of node-positive disease, followed by external beam radiotherapy (E.B.R.T.) to a total dose of 50 to 60 Gy in the tumor bed. Adjuvant E.B.R.T. has been shown to decrease markedly locoregional recurrences and to increase survival in recent studies. Treatment of lymph nodes area is more controversial. Chemotherapy is recommended only for metastatic disease. (authors)

  13. p53在大肠癌中的表达及其临床意义%P53 EXPRESSION AND ITS CLINICAL SIGNIFICANCE INHUMAN COLORECTAL CARCINOM

    Institute of Scientific and Technical Information of China (English)

    雷厉

    2007-01-01

    目的 对大肠癌p53表达进行相关分析,探讨大肠癌中p53基因与肿瘤发生、发展的关系.方法 采用免疫组织化学S-P法,检测52例大肠癌中p53基因的表达.结果 p53表达与大肠癌浸润、转移有关(p<0.05);p53在大肠癌中表达与分化程度具有明显相关性;其与Dukes分期也具有明显相关性.结论 p53可作为临床判断大肠癌生物学行为的有用指标.

  14. Post irradiation eardrum: a rare complication of the radiotherapy of naso-pharynx carcinomas; Necrose tympanique postradique: une complication rare de la radiotherapie des carcinomes nasopharynges

    Energy Technology Data Exchange (ETDEWEB)

    Siala, W.; Mnejja, W.; Daoud, J. [CHU Habib-Bourguiba, Service de Radiotherapie Oncologique, Sfax (Tunisia); Khabir, A. [CHU Habib-Bourguiba, Service d' Anatomopathologie, Sfax (Tunisia); Ghorbel, A. [CHU Habib-Bourguiba, Service d' ORL, Sfax (Tunisia); Frikha, M. [CHU Habib-Bourguiba, Service d' Oncologie Medicale, Sfax (Tunisia)

    2009-10-15

    The eardrum necrosis is a serious and dreadful complication but rarely described after irradiation of cavum cancers. We report in this work five cases of eardrum necrosis after radiotherapy of nasopharynx carcinomas. Patients and methods: between february 1993 and december 2004 239 patients suffering of anon metastatic nasopharynx cancer have been treated by classical irradiation associated or not to a chemotherapy. The radiotherapy was delivered at the dose of 70 to 75 Gy in the cavum and the ganglions initially reached according a classical modality of hyperfractionated one. We analysed retrospectively the delayed complications occurred six months or more after the radiotherapy beginning. Results: Five cases of eardrum necrosis were reported sixty five months after the end of radiotherapy. these patients suffered of hypoacusia and buzzing. The clinical examination allowed to bring out the eardrum perforation that did not exist before radiotherapy. The total dose of irradiation was 75 Gy for a patient and 71.5 Gy according a hyperfractionated modality for four patients. Three patients had an hearing prosthesis in order to improve their quality of life. Conclusion: the eardrum necrosis after radiotherapy for nasopharynx cancer is a rare and unusual complication, very few reported in the literature. The total dose of irradiation is considered as the principal factor of occurrence risk in such complication. (N.C.)

  15. Nasopharynx carcinomas. about 1342 cases treated at Oran, Algeria; Carcinomes du nasopharynx. A propos de 1342 cas traites a Oran, Algerie

    Energy Technology Data Exchange (ETDEWEB)

    Khaldi, H.; Aid, M.; Lahmer, K.; Dali-Youcef, A.F. [Radiotherapie, Oran (Algeria)

    2009-10-15

    The purpose was to describe the epidemiology, clinical and therapy characteristics of the cavum cancer and the different post therapy results. The cavum cancer is frequent in west Algeria. It is the first cancer of superior aero digestive tracts, the fifth one fro man and the seventh for woman. It represents 8% of the whole of cancers treated at the radiotherapy service in Oran. It is chemosensitive and can be cured by radiotherapy but the frequency of locoregional recurrences and metastases remains high, despite all therapeutic methods used. (N.C.)

  16. Pseudo-angiomatous liver metastasis of thyroid medullary carcinoma: multimodality diagnostic approach; Metastase hepatique pseudoangiomateuse d'un carcinome medullaire de la thyroide: approche diagnostique multimodalite

    Energy Technology Data Exchange (ETDEWEB)

    Imperiale, A.; Keomany, J.; Rust, E.; Constantinesco, A. [CHU de Strasbourg, Service de biophysique et medecine nucleaire, 67 (France); Greget, M. [CHU de Strasbourg, Service de radiologie 1, 67 (France); Chabrier, G.; Goichot, B. [CHU de Strasbourg, Service de medecine interne, endocrinologie et nutrition, 67 (France); Detour, J. [CHU de Strasbourg, Service de radiopharmacie, 67 (France); Pessaux, P. [CHU de Strasbourg, Service de chirurgie generale, hepatique et endocrinienne, 67 (France)

    2010-07-01

    Purpose: Illustrate the result of the diagnosis by multimodality imaging (MRI, scintigraphy {sup 123}I-Mibg, PET/CT{sup 18}F-F.D.G. and {sup 18}F-F DOPA) with liver metastasis looking like a single angioma in a patient with atypical medullary thyroid carcinoma. Conclusions: Angiomas must be taken into account in the differential diagnosis of liver metastasis of endocrine tumors, particularly in the case of small injuries where it may be difficult to differentiate a peripheral nodular contrast enhancement of a globular enhancement characteristics of angiomas. (N.C.)

  17. Characterization and localization of c-kit and epidermal growth factor receptor in different patterns of adenoid cystic carcinoma

    Directory of Open Access Journals (Sweden)

    Anshi Jain

    2016-01-01

    Conclusions: C-kit and EGFR biomarkers can be used to enhance the characterization of ACC and to determine the localization of dual cell population which could suggest the dual origin of ACC and provides evidence for the new therapeutic strategy in ACC.

  18. Diagnostic pitfall: Adenoid cystic carcinoma of the tongue presenting as an isolated hypoglossal nerve palsy, case report and literature review

    Directory of Open Access Journals (Sweden)

    Wee Hide Elfrida

    2016-01-01

    In malignancies that have a propensity for PI such as ACC, patients may present atypically with nerve palsies. In infiltrative lesions, the primary tumour may not be evident on magnetic resonance imaging. Therefore, to achieve a diagnosis, a high index of suspicion is required. When the diagnosis is in question, deep biopsy and positron emission tomography may be useful.

  19. Carcinoma adenóide cístico: relato de caso = Adenoid cystic carcinoma: case report

    Directory of Open Access Journals (Sweden)

    Palmeiro, Mariana Reuter

    2005-01-01

    Full Text Available O carcinoma adenóide cístico é uma neoplasia maligna rara de crescimento lento, caracterizado prognóstico reservado, devido a sua agressividade e grande potencial recidivante. A lesão é mais prevalente em pacientes na faixa etária entre 50 e 70 anos, sendo incomum em jovens. O artigo relata um caso de carcinoma adenóide cístico de glândulas salivares menores localizado no palato duro em pacientes com 26 ano, do sexo masculino que foi encaminhado para tratamento no Serviço de Cirurgia de Cabeça e Pescoço

  20. Genetic relatedness between pneumococcal populations originating from the nasopharynx, adenoid, and tympanic cavity of children with otitis media.

    NARCIS (Netherlands)

    Tonnaer, E.L.G.M.; Rijkers, G.T.; Meis, J.F.G.M.; Klaassen, C.H.W.; Bogaert, D.; Hermans, P.W.M.; Curfs, J.H.A.J.

    2005-01-01

    Previous studies have shown that Streptococcus pneumoniae exists in both middle ear effusions and the upper respiratory region from children with otitis media with effusion (OME), but it remains unclear whether these strains represent genetically identical clones. Therefore, it cannot be determined

  1. STS和EST在乳腺癌患者中的表达及临床意义%Expression of steroid sulfatase and estrogen sulfotransferase in breast carcinom and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    张兰凤; 刘巍; 焦婷; 李晓丽; 肖娜; 于洋

    2011-01-01

    目的 探讨硫酸酯酶(steroid sulfatase,STS)、雌激素硫酸转移酶(estrogen sulfotransferase,EST)在乳腺癌组织和正常乳腺组织中的表达与临床病理特征的关系,及STS与EST相互之间的关系.方法 选取术前未行放疗、化疗及内分泌治疗的乳腺癌患者82例,取其术后肿瘤组织和距肿瘤边缘>5 cm的乳腺组织.应用免疫组织化学法,检测STS、EST在乳腺癌组织及正常乳腺组织中的表达,采用卡方检验和spearman法分析其表达及相关性.结果 乳腺癌组织中STS蛋白表达水平高于正常乳腺组织,差异有统计学意义(P=0.000).EST在乳腺癌和正常乳腺组织中的表达差异无统计学意义(P =0.367).在乳腺癌组织中STS与EST的表达水平无差异,两者无相关性(r =0.078,P=0.487).结论 STS、EST的表达与乳腺癌的发生、发展相关.%Objective To investigate the expressions of steroid sulfatase (STS) and estrogen sulfotransferase (EST) in breast cancer and its clinical significance. Methods Eighty-two patients with breast cancer underwent mastectomy, who did not receive radiotherapy, chemotherapy or hormonal therapy before surgery; the cancer tissue and normal breast tissue samples were taken. The expressions of STS and EST in breast cancer and normal breast tissue were examined by immunohistochemisty. Results The expression level of STS in breast cancer tissue was higher than that in normal breast tissue (P = 0. 000). There was no significant difference in expression of EST between breast cancer tissues and normal breast tissues (P = 0.367). The expression of STS was not correlated with EST in breast cancer tissues (P = 0.686). Conclusion The expression of STS in breast cancer tissues is up-graded.

  2. Re-irradiation in stereotactic conditions and cetuximab for local relapses of epidermoid carcinoma of head and neck; Reirradiation en conditions stereotaxiques et cetuximab pour des recidives locales de carcinome epidermoide de la tete et du cou

    Energy Technology Data Exchange (ETDEWEB)

    Vasseur, F.; Comet, B.; Faivre-Pierret, M.; Coche-Dequeant, B.; Degardin, M.; Lefebvre, J.L.; Lacornerie, T.; Lartigau, E. [Departement universitaire de radiotherapie, centre Oscar Lambret, 59 - Lille (France); Universite Lille-2, 59 (France)

    2010-10-15

    The authors report a work aimed at assessing the feasibility and toxicity of a re-irradiation treatment in stereotactic conditions using CyberKnife and cetuximab in the case of local relapses of epidermoid cancers of the ORL sphere. Thirty three patients have been submitted to this treatment between June 2007 and April 2009. Although six patients died by six months, this treatment seems to be a good alternative, and presents an acceptable short-term toxicity. Further studies are needed to compare this technique to other therapeutic techniques, and to assess the risk of long term complications. Short communication

  3. Nasopharynx carcinoma treatment: from the conventional radiotherapy to the conformal radiotherapy with intensity modulation; Traitement du carcinome du nasopharynx: de la radiotherapie conventionnelle a la radiotherapie conformationnelle avec modulation d'intensite

    Energy Technology Data Exchange (ETDEWEB)

    Mokaouim, K.; Grehange, G.; Truc, G.; Peingnaux, K.; Martin, E.; Zanetta, S.; Bruchon, Y.; Bonnetain, F.; Maingon, P. [Centre Georges-Francois Leclerc, 21 - Dijon (France)

    2009-10-15

    The objective of this study was to evaluate retrospectively the impact of factors linked to the radiotherapy realisation on the local and locoregional control, the global survival, the survival without disease of patients suffering of naso-pharynx carcinoma. Conclusion: the patients suffering of a nasopharynx carcinoma treated by irradiation associated to chemotherapy have an improved global survival and an improved survival without disease. The conformal radiotherapy with or without modulated intensity reduce the risk of serous otitis, trismus and xerostomia at long term. It seems necessary to realize multi centric studies with a longer period of follow up before asserting the advantages of the I.M.R.T. in comparison to the classical and conformal technique in the treatment of naso-pharynx carcinomas. (N.C.)

  4. Carcinome épidermoïde sur ulcère chronique de la lèvre supérieure chez une patiente infectée par le VIH.

    Directory of Open Access Journals (Sweden)

    Muriel Sidnoma Ouédraogo

    2016-10-01

    Full Text Available Epidermoid carcinomas account for one third of cutaneous carcinomas. These are the most common cancers in adults. On dark skin, epidermoid carcinomas do not mainly occur on photo-exposed areas but rather complicate chronic ulcers. We are reporting the case of a 39 years old patient, HIV 1 positive being consulted for a budding tumor of the upper lip occurred on chronic erosion that appeared three years before. The histopathological examination of the bioptic specimen and of the resection specimen objectified a differentiated and mature epidermoid carcinoma. The patient was classified as Stage II: T3 N0 M 0. A complete tumor resection was performed followed by a double labial reconstruction by local advancement flap. Chronic ulceration and HIV infection have been identified as factors that favored malignant transformation. Limited access to health facilities has reportedly favored the evolution of lesions towards a complicated form and difficult medical care. The therapeutic challenge was to remove the tumor while preserving the function and aesthetics of the mouth.

  5. Basal cell carcinoma of the scalp after radiation therapy for tinea capitis: 33 patients; Carcinomes basocellulaires du cuir chevelu secondaires a une radiotherapie pour teigne: une serie de 33 malades

    Energy Technology Data Exchange (ETDEWEB)

    Mseddi, M.; Bouassida, S.; Marrekchi, S.; Khemakhem, M.; Gargouri, N.; Turki, H.; Zahaf, A. [Centre Hospitalier Universitaire Hedi Chaker, Service de Dermatologie, Sfax (Tunisia)

    2004-08-01

    Occurrence of basal cell carcinoma (BCC) following radiotherapy for tinea capitis is well known. The aim of this study was to specify the clinical and histological features of these BCC seen in 33 patients (1995 000). Twenty seven men and six women were diagnosed with BCC. The age of onset varied between 32 an 62 years. Radiotherapy was received between 5 and 17 years of age. The interval between irradiation and the onset of carcinoma varied between 21 and 51 years. Total number of lesions was 55. Forty percent of BCC occurred on the occipital area, the number varied from 1 to 5 and the size from 2 to 45 mm. Clinically, the nodular type was found in 51% of cases. Pigment was present in 64% of cases. Histological study showed a nodular aspect in 76% and pigmentation in 63% of cases. Nodular and pigmented type were the predominant BCC occurring after radiotherapy for tinea capitis in our series. In the literature, BCC are the most frequent carcinomas occurring after radiotherapy (70-100%). Pigmentation was not described in other series. The nodular histological form was the most frequent. (author)

  6. Preoperative concomitant radio chemotherapy in bulky carcinoma of the cervix: Institut Curie experience; Chimioradiotherapie concomitante preoperatoire dans les carcinomes du col uterin de stades IB2 a IIB: experience de l'Institut Curie

    Energy Technology Data Exchange (ETDEWEB)

    Kirova, Y.M.; Bourhaleb, Z.; Campitelli, M.; De la Rochefordiere, A. [Institut Curie, Groupe de Gynecologie, Service d' Oncologie et de Radiotherapie, 75 - Paris (France); Alran, S.; Fourchotte, V. [Institut Curie, Groupe de Gynecologie, Service de Chirurgie, 75 - Paris (France); Plancher, C. [Institut Curie, Groupe de Gynecologie, Service de Biostatistique, 75 - Paris (France); Beuzeboc, P.; Cottu, P. [Institut Curie, Groupe de Gynecologie, Service d' Oncologie Medicale, 75 - Paris (France); Petrow, P. [Institut Curie, Groupe de Gynecologie, Service de Radiologie, 75 - Paris (France); Cremoux, P. de; Sastre-Garau, X. [Institut Curie, Groupe de Pathologie, Service de Radiologie, 75 - Paris (France)

    2009-07-15

    Purpose: To evaluate the treatment results of patients (pts) with Figo stage IB2, IIA, IIB cervical carcinoma (C.C.) treated with preoperative radio chemotherapy, followed by extended radical hysterectomy. Patients and methods: Retrospective study of 148 women treated to the Curie Institute for operable Figo Stage IB2 to IIB, biopsy proved C.C.. Among them, 70 pts, median age 46 years, were treated using the same regimen associating primary radio cis-platinum based chemotherapy,intracavitary LDR brachytherapy, followed by extended radical hysterectomy. Kaplan-Meier estimates were used to draw survival curves. Comparisons of survival distribution were assessed by the log-rank test. Results: Complete histological local-regional response was obtained in 56% of the pts (n = 39). Residual macroscopic or microscopic disease in the cervix was observed in 28 pts (40%). All but one had in situ microscopic residual C.C.. Lateral residual disease in the parametria was also present in nine pts, all with residual C.C.. Pelvic lymph nodes were free from microscopic disease in 56 pts (80%). Eight of 55 (11%) radiological N0 patients had microscopic nodal involvement, as compared to 6/15 (40%) radiological N1 (p = 0.03). Seventeen pts (25%) had residual cervix disease but negative nodes. After median follow-up of 40 months (range, 8-141), 38/70 patients (54.1%) are still alive and free of disease, six (8.6%) alive with disease, and 11 (15.8%) patients were lost for follow-up but free of disease. Conclusion: The treatment of locally advanced C.C. needs a new multidisciplinary diagnostic and treatment approach using new therapeutic arms to improve the survival and treatment tolerance among women presenting this disease. (authors)

  7. Neck dissection following chemo radiation for node positive head and neck carcinomas;Place du curage ganglionnaire apres chimioradiotherapie dans les carcinomes epidermoides des voies aerodigestives superieures avec atteinte ganglionnaire initiale (nasopharynx exclu)

    Energy Technology Data Exchange (ETDEWEB)

    Thariat, J. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. de Radiotherapie, Oncologie, 06 - Nice (France); IBDC CNRS UMR 6543, 06 - Nice (France); Thariat, J.; Marcy, P.Y.; Bozec, A.; Peyrade, F.; Hofman, P. [Universite de Nice-Sophia-Antipolis, 06 - Nice (France); Hamoir, M. [Cliniques universitaires Saint-Luc, UCL, Dept. de chirurgie ORL, Bruxelles (Belgium); Janot, F. [Institut Gustave-Roussy, Dept. de chirurgie ORL, 94 -Villejuif (France); De Mones, E. [CHU de Bordeaux, Dept. de chirurgie ORL, 33 - Bordeaux (France); Marcy, P.Y. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. de Radiologie, 06 - Nice (France); Carrier, P. [CHU de Nice, Dept. de Medecine Nucleaire, 06 - Nice (France); Bozec, I. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. chirurgie ORL, 06 - Nice (France); Guevara, J.; Santini, J. [CHU Pasteur, Dept. de chirurgie ORL, 06 - Nice (France); Albert, S. [CHU Bichat, Dept. de chirurgie ORL, 75 - Paris (France); Vedrine, P.O. [CHG Cannes, 06 (France); Graff, P. [Centre de Lutte Contre le Cancer Alexis-Vautrin, Dept. de chirurgie ORL, 54 - Nancy (France); Peyrade, F. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. d' Oncologie Medicale, 06 - Nice (France); Hofman, P. [CHU de Nice, Dept. de Pathologie clinique et experimentale, 06 - (France); Centre de lutte contre le cancer Antoine-Lacassagne, CHU et tumorotheque CHU-CLCC, 06 - Nice (France); Bourhis, J. [Institut Gustave-Roussy, Dept. de Radiotherapie-oncologie, 94 - Villejuif (France); Lapeyre, M. [Centre de lutte contre le cancer Jean-Perrin, Dept. de Radiotherapie-oncologie, 63 - Clermont-Ferrand (France)

    2009-12-15

    The optimal timing and extent of neck dissection in the context of chemo radiation for head and neck cancer remains controversial. For some institutions, it is uncertain whether neck dissection should still be performed up front especially for cystic nodes. For others, neck dissection can be performed after chemo radiation and can be omitted for N1 disease as long as a complete response to chemo radiation is obtained. The question is debated for N2 and N3 disease even after a complete response as the correlation between radiological and clinical assessment and pathology may not be reliable. Response rates are greater than or equal to 60% and isolated neck failures are less than or equal to 10% with current chemo radiation protocols. Some therefore consider that systematic up front or planned neck dissection would lead to greater than or equal to 50% unnecessary neck dissections for N2-N3 disease. Positron-emission tomography (PET) scanning to assess treatment response and have shown a very high negative predictive value of greater than or equal to 95% when using a standard uptake value of 3 for patients with a negative PET at four months after the completion of therapy. These data may support the practice of observing PET-negative necks. More evidence-based data are awaited to assess the need for neck dissection on PET. Selective neck dissection based on radiological assessment and preoperative findings and not exclusively on initial nodal stage may help to limit morbidity and to improve the quality of life without increasing the risk of neck failure. Adjuvant regional radiation boosts might be discussed on an individual basis for aggressive residual nodal disease with extra-capsular spread and uncertain margins but evidence is missing. Medical treatments aiming at reducing the metastatic risk especially for N3 disease are to be evaluated

  8. Epidermoid carcinomas of the anal canal treated with definitive radiation therapy in a series of 305 patients; Carcinomes epidermoides du canal anal traites par irradiation a visee curative: a propos de 305 patients

    Energy Technology Data Exchange (ETDEWEB)

    Deniaud-Alexandre, E.; Touboul, E.; Huang, R.; Qu, S.H.; Pene, F.; Schlienger, M. [Hopital Tenon, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Hopital des Diaconesses, Service de Chirurgie Generale, 75 - Paris (France); Houry, S. [Hopital Tenon AP-HP, Service de Chirurgie Digestive, 75 - Paris (France); Gallot, D. [Groupe Hospitalier Bichat-Claude-Bernard, Service de Chirurgie Generale et Digestive B, 75 - Paris (France)

    2003-08-01

    Purpose. - To identify prognostic factors and treatment toxicity in a series of epidermoid cancers of the anal canal without evident metastasis. Patients and methods. - Between June 1972 and January 1997, 305 patients (pts) were treated with curative-intent radiation therapy (RT). The T-stages according to the 1987 UICC classification were: 26 T1, 141 T2, 104 T3, and 34 T4. There were 49 pts with nodal involvement at presentation. Pretreatment anal function scoring according to our in-house system was: 22 scored 0, 182 scored 1, 74 scored 2, 7 scored 3. 11 scored 4, and 9 not available pts. The treatment started with external beam RT (EBRT) in 303 pts (median dose: 45 Gy). After a rest period of 4 to 6 weeks, a boost of 20 Gy was delivered by EBRT in 279 pts and by interstitial {sup 192}Ir brachytherapy (Bcy) in 17 pts. Seven pts received only one course of EBRT (mean dose: 49.5 Gy) and 2 pts were treated with interstitial {sup 192}Ir Bcy alone (55 and 60 Gy, respectively). concomitant chemotherapy (5-fluoro-uracil and either mitomycin C or cisplatin) was delivered to 19 pts. Mean follow-up was 103 months. Results. - At the end of RT local tumor clinical complete response (cCR) rate was 80%. Out of 61 non responders or local progressive tumors 27 (44%) were salvaged with abdomino-perineal resection (APR). The rate of local tumor relapse (LR) was 12%. Out of 37 LTR, 20 (54%) were salvaged with APR and one with interstitial {sup 192}Ir Bcy. The overall local tumor control (LC) rate with or without salvage local treatment was 84%. LC rate with a good anal function scoring (score 0 and 1) was 56.5%0. Among 181/186 available pts who preserved their anus, 94% had a good anal function scoring. For a subgroup of 15 pts with length tumor <2 cm-N0, the LC rate after the end of RT was 100% the LC rate with or without local salvage treatment was 100%, and among 13 available pts who preserved their anus, the anal function scoring was good in 12 pts (92%). The 10-years disease-free survival was 74%. After multivariate analysis, 3 independent predicting factors significantly influenced the disease-free survival: gap duration between 2 courses of RT (>38 days vs {<=}38 days, P=0.0025), pretreatment anal function scoring (0 vs 1 vs 2 vs 3 vs 4, P =4.4 10{sup -6}), and cCR after the end of RT (no complete response vs complete response, P =2.5 10{sup -14}). Conclusion. - We confirm excellent results with RT in T1 and T2 lesions. However, chemoradiotherapy should be preferred to improves survival free. of colostomy with a good anal sphincter function for tumors more than or equal to 2 cm in length and locally advanced tumors. (author)

  9. sICAM-1、sE-selectin水平在肝癌诊疗中的价值①%The value of measurement of sICAM-1 and sE-selectin in hepatocellular carcinom a (HCC)

    Institute of Scientific and Technical Information of China (English)

    唐南洪; 陈燕凌; 李秀金; 王晓茜; 殷凤峙

    2001-01-01

    目的:探讨血清细胞间粘附分子-1(sICAM-1)、E-选择素(sE-selectin)在肝癌诊疗中的价值.方法:检测健康人、慢胜肝炎、肝硬化、肝癌者手术前后sICAM-1、sE-selectin水平变化.结果:79例各期肝癌者总体sICAM-1、SE-selectin水平明显高于慢性肝炎、肝硬化和健康对照组(P<0.01),但Ⅰ期肝癌组与慢性肝炎、肝硬化组比较无显著差异;各期肝癌术后sICAM1-1及Ⅰ、Ⅱ、Ⅲ期肝癌术后sE-selectin水平均较术前明显下降.结论:提示早期肝癌患者检测血清sICAM-1、sE-selectin无确诊意义 ,但可作为中、晚期肝癌者特别是AFP阴性患者的血清学确诊参考和预后的监测指标.

  10. Preoperative scintigraphic detection of lung metastases of a follicular thyroid carcinoma associated with hyperthyroidism; Detection scintigraphique preoperatoire de metastases pulmonaires d'un carcinome vesiculaire de la thyroide associe a une hyperthyroidie

    Energy Technology Data Exchange (ETDEWEB)

    Biyi, A.; Oufroukhi, Y.; Doudouh, A. [Hopital Militaire d' Instruction Mohammed V, Rabat Instituts, Service de Medecine Nucleaire, Rabat (Morocco); Baizri, H.; El Quatni, M. [Hopital Militaire d' Instruction Mohammed V, Service d' Endocrinologie, Rabat (Morocco); Al Bouzidi, A. [Hopital Militaire d' Instruction Mohammed V, Service d' Anatomie Pathologique, Rabat (Morocco)

    2009-10-15

    Preoperative accumulation of radioiodine in metastases of thyroid carcinoma and its association with hyperthyroidism are uncommon. We report a case of 58-year-old woman with follicular thyroid carcinoma revealed by thyrotoxicosis caused by a hot nodule, and bilateral pulmonary uptake of I-131 before total thyroidectomy. Despite four ablative doses of I-131, bone metastases were identified and the patient died 42 month after the initial diagnosis. (authors)

  11. Secondary mandibular fibrosarcoma after chemoradiotherapy for undifferentiated nasopharyngeal carcinoma. Report of a case and literature review; Fibrosarcome secondaire de la mandibule apres chimioradiotherapie pour carcinome indifferencie du nasopharynx. A propos d'une observation et revue de la litterature

    Energy Technology Data Exchange (ETDEWEB)

    Kochbati, L.; Besbes, M.; Benna, F.; Maalej, M. [Institut Salah Azaiz, Service de Radiotherapie, Tunis (Tunisia); Boussen, H.; Ben Ayed, F. [Institut Salah Azaiz, Service de Medecine, Tunis (Tunisia); Gritli, S.; Ladgham, A. [Institut Salah Azaiz, Service de Chirurgie ORL, Tunis (Tunisia); Saadi, A. [Institut Salah Azaiz, Service de Radiodiagnostic, Tunis (Tunisia); El May, A. [Institut Salah Azaiz, Service d' Anatomopathologie, Tunis (Tunisia)

    2001-06-01

    Secondary mandibular fibrosarcoma after chemoradiotherapy for undifferentiated nasopharyngeal carcinoma. Report of a case and literature review. Secondary tumours to radio- and/or chemotherapy have rarely been reported after treatment for head and neck cancers. We report a case of mandibular fibrosarcoma observed 7 years after chemoradiotherapy for undifferentiated nasopharyngeal carcinoma in a patient treated when 20 years old. (authors)

  12. Sentinel lymph node detection in oropharynx and oral cavity; Interet de la detection du ganglion sentinelle dans les carcinomes epidermoides de la cavite buccale et de l'oropharynx

    Energy Technology Data Exchange (ETDEWEB)

    Chesnay, E.; Bouvard, G. [Centre Hospitalier Universitaire, Service de Medecine Nucleaire, 14 - Caen (France); Benateau, H.; Halley, A.; Compere, J.F. [Centre Hospitalier Universitaire, Service de Chirurgie Maxillo-Faciale et Stomatologie, 14 - Caen (France); Babin, E.; Bequignon, A. [Centre Hospitalier Universitaire, Service de d' Oto-Rhino-Laryngologie et Chirurgie Cervico-Faciale, 14 - Caen (France); Comoz, F. [Centre Hospitalier Universitaire, Service d' Anatomo-Pathologie, 14 - Caen (France)

    2004-03-01

    The sentinel lymph node (SLN) is the first lymph node draining the tumour. Aim of the study: To determine the negative predictive value of the SLN in the NO or NI squamous cell carcinomas (SCC) of the oral cavity or the oropharynx. Materials and method: SLN localization firstly requires a lymphoscintigraphy which is realised after four injections of radiolabelled colloids around the tumour. This scintigraphy allows a cutaneous marking of the SLN. Per operative detection of the SLN is performed with a detection probe. Results: One or more SLN have been localized in 20 of the 21 patients. No SLN was found in one patient whose tumour was a recurrence. (T2 NO MO) of a SCC of the oropharynx irradiated 3 years before. The failure rate of the method is 4,8% (1 false negative in 21 patients) and the false negative rate is 12,5% (1 false negative in 8 positive patients). This false negative patient had a T3 NO MO SCC of the oropharynx with a SLN found in level III, deep lateral cervical group. The neck dissection revealed one positive node in level lb, submandibular group, and 27 other nodes, all negative. The probability for the whole neck dissection to be negative when the SLN is negative (negative predictive value), is 92,3% (12/13) in our study. Conclusion: Our patient population is too small to obtain statistically significant conclusions. A maximum of 2 % of false negative patients is necessary to apply this method and avoid complete neck dissection in NO and NI tumours of the the oral cavity and the oropharynx with a negative SLN. (author)

  13. Retrospective study of the local control and the cosmetic result of 147 face carcinomas after interstitial brachytherapy; Etude retrospective du controle local et du resultat cosmetique de 147 carcinomes de la face apres curietherapie interstitielle

    Energy Technology Data Exchange (ETDEWEB)

    Ducassou, A.; David, I.; Bonnet, J.; Delannes, M. [Institut Claudius-Regaud, Service de Radiotherapie, 31 - Toulouse (France)

    2009-10-15

    The purpose was to evaluate retrospectively the local control rate and the cosmetic results for patients that received an interstitial brachytherapy for a base or spino-cellular carcinoma of face orifices areas. The interstitial brachytherapy by iridium 192 is an excellent alternative to surgery in the skin carcinomas of the face, as well at the level of local control as the cosmetic and functional results. (N.C.)

  14. Oesophageal squamous cell carcinoma Stade 3. State of surgery after radio chemotherapy (R.C.T.); Carcinomes malpighiens de l'oesophage de stade 3, place de la chirurgie apres chimioradiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Triboulet, J.P.; Mariette, C. [Hopital Claude-Huriez, Service de Chirurgie Digestive et Generale, 59 - Lille (France)

    2006-11-15

    Neo-adjuvant chemoradiotherapy is the gold standard of the treatment of advanced oesophageal squamous cell carcinoma. The role of surgery L. chemoradiotherapy is still debated. Feasibility of curative resection depends on dose of radiotherapy, morbi-mortality rates, and nutrition status at the end of the protocol especially for non-responders patients. Adding surgery to radio-chemotherapy improves local tumour control but does not increase overall survival of patients with advanced oesophageal squamous cell carcinoma. According to the two randomized trials published on the subject, surgery is not recommended after chemoradiotherapy for responders. Recommendations of French National Thesaurus are: exclusive chemoradiotherapy as reference, oesophagectomy for residual tumour as alternative for operable patients. Surgery may be proposed for selected non-responders patients and some complete pathology response in expert center. (author)

  15. Interest of a treatment combined by radioimmunotherapy and Avastin 1 in a murine model of thyroid medullary carcinoma; Interet d'un traitement combine par radioimmunotherapie et Avastin1 dans un modele murin de carcinome medullaire de la thyroide

    Energy Technology Data Exchange (ETDEWEB)

    Salaun, P.Y.; Bodet-Milin, C.; Paris, F.; Frampas, E.; Sai Maurel, C.; Faivre Chauvet, A.; Barbet, J.; Kraeber Bodere, F. [Unite Inserm U892, Brest, (France)

    2009-05-15

    The objective of this study was to evaluate the efficiency and the toxicity of the association radioimmunotherapy and bevacizumab on a murine model grafted by the human line T.T. of thyroid medullar cancer. After results it appears that in pretreatment, bevacizumab (Avastin) improves the efficiency of radioimmunotherapy without increasing the toxicity face the radioimmunotherapy alone. (N.C.)

  16. Retrospective study of patients treated for a carcinoma of the vocal chords by exclusive irradiation; Etude retrospective de patients traites pour un carcinome des cordes vocales par irradiation exclusive

    Energy Technology Data Exchange (ETDEWEB)

    Servagi Vernat, S.; Bontemps, P.; Bosset, J.F. [Service de Radiotherapie-oncologie, 25 - Besancon (France); Pozet, A.; Mercier, M. [Laboratoire de Biostatistique, 25 -Besancon (France)

    2007-11-15

    The objectives of this study are to evaluate the tumor local control, the survival, the acute and delayed toxicity after exclusive radiotherapy for a vocal chords carcinoma. This study confirms the literature data. At distance, it appears that the rate of second cancer is the vital element. Also, it would be interesting to make a prospective analysis of the voice quality before and after radiotherapy. (N.C.)

  17. (E)VALUATION DE L'EXPRESSION DES R(E)GULATEURS DU CYCLE CELLULAIRE EN G1/S DANS LE CARCINOM(E)PIDERMO(I)DE DE L'SOPHAGE

    Institute of Scientific and Technical Information of China (English)

    张帆; 吴平平; 颜召文; 李晓芳; 姜叙诚; 朱建善; 唐剑敏

    2003-01-01

    Objective To study the expression of p16, cyclin D1, Rb and phosphorylated Rb(Ser795) in the esophageal squamous cell carcinoma. Methods Immunohistochemistry was performed and analysed on 34 cases of paraffin-embedded tissues. Results The expression of phosphorylated Rb(Ser795) was positively correlated to that of cyclin D1 (r=0.401, P=0.021) and inversely to that of p16 (r=-0.348, P=0.044). In stepwise regression and the best subset regression, the expression of p16 (P=0.034) and phosphorylated Rb(Ser795) (P=0.030) were the only determinants of the mitotic index. Conclusion The expression of phosphorylated Rb(Ser795) could be considered as a mark of the interaction between p16 and cyclin D1. The detection of phosphorylated Rb, p16 and cyclin D1 will be possibly helpful to the oncogenesis investigation on the esophageal carcinoma.

  18. Interest of the serous dosage of HER-2/neu, EGFr, VEGF, IL6 and Ac anti-P53 among patients damaged by an esophagus epidermoid carcinoma, type epidermoid carcinoma whom treatment was an exclusive chemoradiotherapy; Interet du dosage serique de HER-2/neu, EGFr, VEGF, IL6 et Ac anti-P53 chez des patients atteints d'un carcinome epidermoide de l'oesophage de type carcinome epidermoide dont le traitement etait une chimioradiotherapie exclusive

    Energy Technology Data Exchange (ETDEWEB)

    Metges, J.P.; Le Tallec-Jestin, V.; Mahlaire, J.P.; Pradier, O. [Departement de Cancerologie, 29 - Brest (France); Guenet, D.; Volant, A. [Service d' anatomopathologie, 29 - Brest (France); Codet, J.P. [Service de Medecine Nucleaire, 29 - Brest (France)

    2006-11-15

    The serous concentrations of EGFr and HER2/neu seem to have a potential interest in the framework of the assumption of esophagus epidermoid carcinomas. A next step consists in comparing the serous value of these markers with their tissue expression on biopsies. A prospective study in parallel of a therapeutic trial is starting up to validate these results on a bigger number of patients. (N.C.)

  19. Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy

    Science.gov (United States)

    2017-01-26

    Adenoid Cystic Carcinoma; Squamous Cell Carcinoma; Sinonasal Carcinoma; Sinonasal Undifferentiated Carcinoma; Mucoepidermoid Carcinoma; Schneiderian Carcinoma; Myoepithelial Carcinoma; Esthesioneuroblastoma; Melanoma

  20. Adenotonsiller Hipertrofinin Effüzyonlu Otitis Media Üzerine Etkileri

    OpenAIRE

    Bayındır, Tuba; Toplu, Yüksel; Kızılay, Ahmet

    2013-01-01

    Obstructive hypertrophy with adenoid and/or tonsil inflammation is one of the most common problems in pediatric group patients. Especially adenoid tissue, which is a component of Waldeyer's ring, may play an important role in the pathogenesis of otitis media, according to its anatomic position, when inflamed and/or enlarged. Therefore, adenoid surgery is thought to have a role in the management of otitis media with effusion. According to the relationship between the adenoid tissue and eustach...

  1. Inhibitory effect of mistletoe alkali on adenoid cystic carcinoma cells%槲寄生碱对人腺样囊性癌细胞的抑制作用

    Institute of Scientific and Technical Information of China (English)

    李亚娟; 周洪澜; 葛岩; 张丽红; 王心蕊; 廖翔宇; 高婷; 王医术

    2008-01-01

    目的:研究槲寄生碱对人腺样囊性癌(ACC)细胞生长的抑制作用.方法:以5-氟尿嘧啶(5-FU)作用组为阳性对照组,以不加药组为阴性对照组,实验组为0.625、1.250、2.500和5.000 mg·L-1槲寄生组.采用CCK-8试剂盒测定槲寄生碱对ACC细胞的抑制作用,通过绘制细胞生长曲线观察药物作用后细胞的生长情况及状态.利用PCNA免疫化学染色观察槲寄生碱对ACC细胞增殖的影响.结果:槲寄生碱可抑制ACC细胞的生长,其IC50值为2.24 mg·L-1;生长曲线显示,药物作用后的ACC细胞生长较对照组缓慢;形态学观察显示药物作用后的ACC细胞逐渐变为圆形,附壁性减弱;药物作用后的ACC细胞PCNA的表达率明显弱于对照组(P<0.001).结论:槲寄生碱可以抑制ACC细胞生长、增殖,有望成为临床治疗ACC的辅助药物.

  2. Resection and Reconstruction of Maxillary Class IIIc Defect in a Case of Adenoid Cystic Carcinoma: Cost-Sensitive Technique without Microvascular Grafts

    Directory of Open Access Journals (Sweden)

    Dwarkadas Adwani

    2013-01-01

    Full Text Available ACC is a rare malignant tumor that affects most commonly the major and minor salivary glands and rarely the paranasal sinuses, lacrimal gland, larynx, ear, vulva, and so forth. The maxillary sinus when affected is considered having a poor prognosis due to delayed diagnosis and delayed treatment credited to its slow spread, late symptoms, and complex anatomy which hampers surgical resection. The expressions of tumor markers too have a significant role in determining the prognosis. The treatment of choice consists of wide radical resection of the tumor followed by radiotherapy. Rehabilitation options in cases with huge maxillary defects still need further exploration.

  3. 山竹果皮中总氧杂蒽酮对人鼻咽癌CNE2细胞增殖及凋亡的影响%Effects of the Xanthones from Pericarps of Mangosteen on Proliferation and Apoptosis of Human Nasopharyngeal Carcinom Cell Line CNE2

    Institute of Scientific and Technical Information of China (English)

    赖燕燕; 黄应雯; 黄丹玚; 伍兰岚; 罗彬尤; 李晓龙

    2016-01-01

    目的 探讨山竹果皮中总氧杂蒽酮提取纯化物对人鼻咽癌CNE2细胞增殖及凋亡的影响及其作用机制.方法 将人鼻咽癌CNE2细胞随机分成阴性对照组和不同浓度山竹果皮中总氧杂蒽酮提取纯化物组.阴性对照组不加药物,正常培养;总氧杂蒽酮提取纯化物组分别以200,400,600,800 μmol·L-1总氧杂蒽酮作用24,48,72 h.采用噻唑蓝(MTT)法检测不同浓度总氧杂蒽酮提取纯化物对CNE2细胞增殖的影响,Annexin-V/PI双重染色、碘化丙啶单染进行流式细胞术检测总氧杂蒽酮提取纯化物对CNE2细胞周期和凋亡的影响.Caspase-3试剂盒检测总氧杂蒽酮提取纯化物对CNE2细胞Caspase-3酶活化的影响.结果 总氧杂蒽酮提取纯化物随着浓度增加,可显著抑制人鼻咽癌CNE2细胞的增殖活性,浓度为371.536 7 μmol·L-1时可诱导人鼻咽癌CNE2细胞出现明显早期凋亡,并且随着药物作用时间的增加(24,48,72 h),凋亡早期癌细胞的比例显著上升(分别为0.03%,10.54%,26.47%)(P<0.05);总氧杂蒽酮提取纯化物使CNE2细胞G1期细胞比例大幅升高,同时S期细胞比例明显下降;对Caspase-3具有激活作用,Caspase-3酶的活性与药物浓度成正比.结论 山竹果皮中总氧杂蒽酮提取纯化物对人鼻咽癌CNE2细胞增殖有显著抑制作用和促凋亡作用,其作用机制可能与抑制鼻咽癌细胞增殖活性、抑制细胞进入S期和激活Caspase-3有关.

  4. Concomitant chemoradiotherapy with folfox-cetuximab in stage III oesophagus and cardia carcinomas: final results of the phase-II Erafox study of the Gercor group; Chimioradiotherapie concomitante par folfox-cetuximab dans les carcinomes du cardia et de l'oesophage de stade III: resultats definitifs de l'etude de phase II Erafox du groupe Gercor

    Energy Technology Data Exchange (ETDEWEB)

    Lledo, G.; Mammar, V.; Michel, P. [Hopital Jean-Mermoz, Lyon (France); Dahan, L. [CHU Rouen, Rouen (France); Mineur, L.; Dupuis, O. [Institut Sainte-Catherine, 84000 Avignon (France); Galais, M.P. [CHU Timone, Marseille (France); Chibaudel, B. [InstitutJean-Godinot, Reims (France); Jovenin, N. [Gercor, Paris (France); Gramont, A. de [Hopital Saint-Antoine, Paris (France)

    2011-10-15

    The authors report and discuss the results of a French national multicentre study which aimed at assessing the efficiency and tolerance of a folfox- and cetuximab-based chemotherapy concomitant with a radiotherapy for the treatment of stage-III cardia and oesophagus cancers. Patients (60 men and 19 women) have been selected according to the carcinoma type, performance index, age, weight loss over the last six months. Results are discussed in terms of response, steadiness, advancement, grade 3 and 4 toxicity, and side effects. The therapeutic efficiency corresponds to an objective response rate of 77 per cent, and tolerance profile seems to be acceptable for patients suffering from locally advanced cardia and oesophagus cancer. Short communication

  5. Study of the correlation between immunohistochemistry of the initial tumor and PET/CT after recombining TSH (RHTSH) in case of tumor recurrence in differentiated thyroid carcinomas; Etude de la correlation entre l'immunohistochimie de la tumeur initiale et la TEP-FDG/TDM apres TSH recombinante (RHTSH) en cas de recidive tumorale dans les carcinomes thyroidiens differencies

    Energy Technology Data Exchange (ETDEWEB)

    Lansoy-Kuhn, C.; Mechken, F.; Edet-Sanson, A.; Vera, P. [Centre Becquerel and QuantIF LITIS EA4108, Service de medecine nucleaire, 76 - Rouen (France); D' anjou, J.; Cornic, M. [Centre Henri-Becquerel, service anatomopathologie, 76 - Rouen (France)

    2010-07-01

    Purpose: In patients with differentiated thyroid carcinoma, the correlation between the value of thyroglobulin and the positivity of F.D.G.-PET remains controversial. We looked at whether the immunohistochemical criteria of the original tumor could be predictive of a positive PET in cases of tumor recurrence. Conclusions: on a larger series, we have not confirmed the results of Hooft (JCEM 2005). This study did not reveal immunohistochemical marker, present in the original tumor, which would be predictive of a positive PET-F.D.G. in the search for a recurrence. The study of NIS and GLUT1 expression is underway. (N.C.)

  6. Concomitant bid radiotherapy with cisplatin and 5-fluorouracil in unresectable carcinoma of the pharynx: 10 year's experience at the Centre Antoine Lacassagne; Radiotherapie bifractionnee et chimiotherapie par cisplatine et 5-fluoro-uracile concomitantes dans les carcinomes epidermoides localement evolues non resecables du pharynx: dix ans d'experience au centre Antoine Lacassagne

    Energy Technology Data Exchange (ETDEWEB)

    Magne, N.; Pivot, X.; Marcy, P.Y.; Chauvel, P.; Courdi, A.; Dassonville, O.; Possonnet, G.; Vallicioni, J.; Ettore, F.; Falewee, M.N.; Milano, G.; Santini, J.; Lagrange, J.L.; Schneider, M.; Demard, F.; Bensadoun, R.J. [Centre Antoine-Lacassagne, 06 - Nice (France)

    2001-08-01

    Patients suffering from locally advanced unresectable squamous cell carcinoma of the oropharynx and hypopharynx treated with radiotherapy alone have a poor prognosis. More than 70% of patients die within 5 years mainly due to local recurrences. The aim of this study was to evaluate retrospectively the Antoine Lacassagne Cancer Center's experience in a treatment by concomitant bid radiotherapy and chemotherapy. Evaluation was based on analysis of the toxicity, the response rates, the survival, and the clinical prognostic factors. From 1992 to 2000, 92 consecutive patients were treated in our single institution. All of them had stage IV, unresectable squamous cell carcinoma of the pharynx and they received continuous bid radiotherapy (two daily fractions of 1.2 Gy, 5 days a week, with a 6-h minimal internal between fractions). Total radiotherapy dose was 80.4 Gy on the oropharynx and 75.6 Gy on the hypopharynx. Two or three chemotherapy courses of cisplatin (CP)-5-fluorouracil (5FU) were given during radiotherapy at 21 -day intervals (third not delivered after the end of the radiotherapy). CP dose was 100 mg/m{sup 2} (day 1) and 5-FU was given as 6-day continuous infusion (750 mg/m{sup 2}/day at 1. course; 430 mg/m{sup 2}/day at 2. and 3. courses). Special attention was paid to supportive care, particularly in terms of enteral nutrition and mucositis prevention by low-level laser energy. Acute toxicity was marked and included WHO grade III/IV mucositis (89%, 16% of them being grade IV), WHO grade III dermatitis (72%) and grade III/IV neutropenia (61%). This toxicity was significant but manageable with optimised supportive care, and never led to interruption of treatment for more than 1 week, although there were two toxic deaths. Complete global response rate at 6 months was 74%. Overall global survival at 1 and 3 years was 72% and 50% respectively, with a median follow-up of 17 months. Prognostic factors for overall were the Karnofsky index (71% survival at 3 years for patients with a Karnofsky index of 90-100% versus 30% for patients with a Karnofsky index of 80% versus 0% for patients with a Karnofsky index of 60-70%, p = 0.0001) and tumor location (55% at years for oropharynx versus 37% for pan-pharynx versus 28% for hypopharynx, p=0.009). These results confirm the efficacy of concomitant bid radiotherapy and chemotherapy in advanced unresectable tumor of the pharynx. The improvement in results will essentially depend on our capacity to restore in a good nutritional status the patients before beginning this heavy treatment. (author)

  7. Radioinduced pulmonary fibrosis: prospective study of clinical, dosimetric and biological predictive factors after conformal irradiation of non at small cells bronchi carcinomas; Fibroses radiques pulmonaires: etude prospective des facteurs predictifs cliniques, dosimetriques et biologiques apres irradiation conformationnelle des carcinomes bronchiques non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Claude, L.; Ginestet, C.; Martel-Lafay, I.; Carrie, C. [Centre Leon-Berard, 69 - Lyon (France); Etienne-Mastroiani, B. [Hopital Louis-Pradel, 69 - Lyon (France); Arpin, D. [Hopital de la Croix-Rousse, 69 - Lyon (France); Vincent, M. [Hopital Saint-Luc-Saint-Joseph, 69 - Lyon (France); Falchero, L. [Hopital de Villefranche, 69 - Villefranche s/Saone (France); Blay, J.Y. [Hopital Edouard-Herriot, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, 69 - Lyon (France)

    2007-11-15

    This broad prospective study confirms the contribution of dosimetry factors ( pulmonary average dose, V10 to V50) in the predictive part for the delayed radioinduced fibrosis. Contrary to the acute radioinduced pneumopathy, no significant relationship has been underlined between the variations of cytokines and the delayed radioinduced fibrosis risk. (N.C.)

  8. Check-up and follow-up of papillary and follicular thyroid carcinoma in the department of nuclear medicine at Ibn Sina hospital Rabat; Bilan et surveillance des carcinomes papillaire et vesiculaire de la thyroide dans le service de medecine nucleaire de l'hopital Ibn Sina de Rabat

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    Ben Rais Aouad, N.; Ghfir, I.; Guerrouj, H.; Fellah, S.; Rahali, J.; Ksyar, R.; Missoum, F.; Bssis, A.; Azrak, S. [CHU Ibn Sina, Service de Medecine Nucleaire, Rabat (Morocco)

    2009-10-15

    In the department of nuclear medicine at Ibn Sina university hospital. Thyroid carcinoma follow-up strategy has been modified and includes cervical ultrasonography and thyroglobulin measurement. The role of radio-iodine scanning in the management of differentiated thyroid carcinoma is decreasing. Papillary and follicular carcinoma have good prognosis but late metastases exist and can lead to death. A lifelong follow-up is therefore mandatory. The main goal of follow-up is to detect earlier persistent or recurrent disease. (authors)

  9. Air breath control radiotherapy in severe insufficiency respiratory patients with N.S.C.L.: application for deformable registration method in thoracic radiotherapy; Radiotherapie avec blocage respiratoire pour les grands insuffisants respiratoires atteints d'un carcinome pulmonaire non a petites cellules (Protocole RESPI 2000): application a la modelisation des deformations d'organes par recalage deformable

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    Sarrut, D.; Pommier, P.; Carrie, C. [Centre Leon-Berard, Dept. de Radiotherapie, CREATIS, Unite CNRS 5515, Inserm 630, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, Dept. de Biostatistique, 69 - Lyon (France)

    2006-11-15

    Purpose. Using deformable registration methods from a phase two clinical study of air breath control during radiotherapy in patients suffering from severe respiratory insufficiency and non-small cell lung carcinoma. Patients and methods, Between April 2002 and November 2005, 22 patients with severe respiratory insufficiency were treated with curative intent by conformal therapy combined with active breathing control. Results. After a mean of follow-up of 22 months, the local control rate is 28% and the method is feasible despite the severe respiratory insufficiency. However the overall survival is still poor due to metastatic widespread. For the second part of the study, the clinical protocol was also used for two studies using deformable registration methods. In the first study, a deformable registration method has been developed in order to register several breath-hold 3D CT of the same patient acquired at several days of interval. It allowed quantifying the inter-fraction breath-hold reproducibility by analysing the resulting displacement field. For 6 patients, the breath-hold was effective, while for 2 patients, motion greater than 10 mm were detected. The second study aimed to simulate 4D images from 3D breath-hold images. Developing an ad-hoc methodology based on the interpolation of 3D dense deformation fields performed it. The approach has been validated with expert selected landmarks, with accuracy lower than 3 mm. Conclusion. ABC is feasible, even in case of severe insufficiency respiratory syndrome but metastatic widespread disease is still a major challenge even with an acceptable local control rate without serious side effects: regarding the deformable registration method. Such artificial 4D images could allow decreasing the dose need to acquire a full 4D image, to simulate irregular breathing pattern and to be used for 4D dosimetry planning. (author)

  10. Impact of additional cervical dedicated {sup 18}FDG-PET-CT on the management of head and neck squamous cell carcinoma; Impact therapeutique de l'acquisition cervicale dediee en [{sup 18}F]-FDG-TEP-TDM sur la prise en charge des carcinomes epidermoides de la tete et du cou

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    Queneau, M.; Tourdias, T.; Guyot, M.; Allard, M.; Fernandez, P. [CHU Pellegrin-Tripode, Service de Medecine Nucleaire, 33 - Bordeaux (France); Houliat, H. [CHU Pellegrin-Tripode, Service d' Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale du Pr Bebear, 33 - Bordeaux (France)

    2008-09-15

    Aim of the study: To investigate the therapeutic impact of additional cervical dedicated {sup 18}F.D.G.-PET-CT on the management of head and neck squamous cell carcinoma (H.N.S.C.C.). Materials and methods: Thirty patients with H.N.S.C.C. underwent a [{sup 18}F]-F.D.G.-PET-CT standard, whole-body scan completed by a cervical dedicated protocol. Two physicians blindly reviewed the exams and the results were discussed with surgeons to determine the therapeutic impact of the dedicated protocol. Result: Among 30 patients, only four (13%) discordant results were registered by the both observers, and two more by only one observer (k = 0.75, S.D. = 0.08). As to the four patients: 1) a N0 staged patient on whole body (W.B.) exam was upstaged to N2b in cervical PET (obese patient, whole-body exam with poor quality), 2) for a second patient, no node was described on whole-body scan, but one lymph node in each cervical chain was observed in focused PET, with low standardized uptake value (S.U.V. value), 3) in the other two cases, cervical PET scan upstaged from N2a to N2b and from N2a to N2c (S.U.V. < 3), without any influence on treatment management. Conclusion: Our results show that additional cervical dedicated PET-CT does not modify the management of patients with H.N.S.C.C. when compared to whole-body PET-CT, except for particular obese or N0 patients, allowing to reduce patient CT radiation dose and time-consuming PET acquisition. (authors)

  11. Irradiation of hepatocellular carcinoma: Impact of breathing on motions and variations of volume of the tumor, liver and upper abdominal organs; L'irradiation des carcinomes hepatocellulaires: impact de la respiration sur les mouvements et variations de volume de la tumeur, du foie et des organes intra-abdominaux

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    Kubas, A.; Mornex, F.; D' Hombres, A.; Lorchel, F.; Chapet, O. [Centre hospitalier Lyon-Sud, Service de Radiotherapie-oncologie Rhone-Alpes, 69 - Pierre-Benite (France); Merle, P. [Hopital de l' Hotel-Dieu, Service d' Hepatogastroenterologie, 69 - Lyon (France)

    2008-12-15

    Purpose: To evaluate the amplitude of motion and the variations of volume of the tumor, the liver and upper abdominal organs induced by breathing during the irradiation of hepatocellular carcinoma (H.C.C.). Material and methods: Two scanners were performed in inhale and in exhale not forced in 20 patients with a H.C.C.. The liver (left/right lobes), the tumor, the duodenum, the two kidneys and the pancreas were delineated on each acquisition. The superposition of the two spirals made it possible to measure the displacements and variations of volume of these structures in the cranio caudal (C.C.), lateral (Lat), and anteroposterior (A.P.) directions. Results:The mean displacement of the tumour in C.C., Lat and A.P. was of 19.7 {+-} 8.3 mm, 4.5 {+-} 2.3 mm, and 8.9 {+-} 6.5 mm. The greatest amplitude of movement was obtained in C.C. for the right and left hepatic lobes (19 {+-} 6.5 mm, 10 {+-} 5.6 mm), the duodenum(12.6 {+-} 6.4 mm), the kidneys right and left (15.5 {+-} 6.1 mm, 16.2 {+-} 10 mm) and the pancreas (13.2 {+-} 6 mm). No significant variation of volume was observed for these organs. Conclusion: The movements of the tumour, the liver and the abdominal organs, induced by breathing are significant. The respiratory gating appears essential in particular with the development of new techniques of irradiation such as the intensity-modulated radiotherapy (I.M.R.T.) or the stereotactic body radiation therapy (S.B.R.T.). (authors)

  12. Impact of {sup 18}F-fluoro-deoxy-glucose positron emission tomography (F.D.G.-PET) in recurrent colorectal cancer; Evaluation de la TEP au {sup 18}F-F.D.G. dans l'exploration de la recidive des carcinomes colorectaux

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    Metrard, G.; Morel, O.; Girault, S.; Soulie, P.; Guerin-Meyer, V.; Lorimier, G.; Gamelin, E. [Centre Paul-Papin, 49 - Angers (France); Metrard, G.; Jeanguillaume, C.; Berthelot, C.; Le Jeune, J.J. [Centre Hospitalier Universitaire, Service de Medecine Nucleaire, 49 - Angers (France); Parot-Schinkel, E. [Centre Hospitalier Universitaire, Service de Recherche Clinique, 49 - Angers (France)

    2009-09-15

    Purpose The aim of the study was to evaluate the diagnostic performance, the prognosis factors and the therapeutic impact of {sup 18}F-F.D.G. positron emission tomography (F.D.G.-PET) in the detection of recurrent colorectal cancers. Methods Sixty PET/CT with {sup 18}F-F.D.G. and CT were performed in 52 patients, at the Paul Papin cancer center between 2003 and 2005, following suspicion of colorectal cancer relapse. The F.D.G.-PET impact on the clinical management was studied by examination of multidisciplinary consultations results. Survival analysis were realized with a mean follow up of 2.2 years. Results Recurrence was confirmed for 50 explorations by histologic (n = 32), radiologic (n = 14) or clinical (n = 4) findings. Twenty patients died during the time of the study. On a patient based analysis, F.D.G.-PET sensitivity, specificity and overall accuracy were 90, 90, 90% respectively compared with 74, 50 and 70% for CT. F.D.G.-PET changed the clinical management in 18 cases (30%). A positive F.D.G.-PET signal, more than one hepatic lesion, more than two lymph node lesions detected on F.D.G.-PET and more than two hepatic lesions on CT were characterized as bad prognostic factors for survival. Multivariate analysis showed that the only independent bad prognostic factor was the F.D.G.-PET detection of more than two liver lesions. Conclusion These results confirmed the important impact of F.D.G.-PET in the clinical management of patients with a suspected recurrence of colorectal cancer. (authors)

  13. Combination of radiotherapy and cetuximab for patients suffering from of an advanced and non operable epidermoid carcinoma of the ORL sphere: results and side effects; Association de radiotherapie et de cetuximab chez des patients atteints d'un carcinome epidermoide de la sphere ORL evolue non operable: resultats et effets secondaires

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    Acevedo, C.; Valette, G.; Bouchekoua, M.; Marianowski, R.; Pradier, O. [CHU Morvan, 29 - Brest (France)

    2010-10-15

    The authors report a retrospective survey of a set of locally advanced epidermoid carcinomas treated by irradiation and cetuximab. They assessed the response to the treatment, the specific survival, and the global survival as well as the tolerance. The survey is based on 31 men and 5 women suffering from different stage 4 non-metastatic advanced epidermoid carcinomas of the ORL sphere. Short communication

  14. Fluoro choline({sup 18}F) has a clinical usefulness in prostate cancer and in hepatocellular carcinoma sometimes in the same patient;La fluorocholine({sup 18}F) a une utilite clinique dans le cancer de la prostate et le carcinome hepatocellulaire parfois chez le meme malade

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    Balogova, S.; Kerrou, K.; Huchet, V.; Gutman, F.; Montravers, F.; Talbot, J.N. [Universite Pierre-et-Marie-Curie, Service de medecine nucleaire, hopital Tenon, AP-HP, 75 - Paris (France); Balogova, S. [Universite Comenius, Bratislava (Slovakia); Bumsel, F. [Universite Pierre-et-Marie-Curie, Service d' hepato-gastro-enterologie, hopital Saint-Antoine, AP-HP, 75 - Paris (France); Nataf, V. [Hopital Tenon, AP-HP, Radiopharmacie, 75 - Paris (France); Mal, F. [Institut mutualiste Montsouris, Departement de pathologie digestive, 75 - Paris (France)

    2010-07-15

    Case report: In order to stage hepatocellular carcinoma (H.C.C.), a patient was referred to PET/CT using fluorodeoxyglucose({sup 18}F) (F.D.G.) and, if necessary, fluoro choline({sup 18}F) (F.C.H.). H.C.C. was proven by biopsy of a hepatic mass discovered on CT performed for a biological recurrence of prostate cancer. Result: F.D.G. PET/CT did not show any anomaly. F.C.H. PET/CT was thus performed and showed various foci: the hepatic mass, a large abdominal adenopathy and an unexpected sub centimeter lung nodule. The diagnostic uncertainty mostly concerned this lung nodule which was biopsied and consisted of a metastasis of the prostate cancer. Due to the presence of two metastatic cancers, the patient's management was altered, with chemotherapy for the H.C.C. and hormone therapy for the prostate cancer. Conclusion: Several types of cancer take-up fluoro choline({sup 18}F), which is a powerful tool to detect metastases, in particular in case of rising levels of marker with a negative F.D.G. PET/CT. Even when F.D.G. PET/CT is positive, F.C.H. may reveal unexpected foci with other metabolic characteristics, although it is not specific of a given primary cancer, as well as F.D.G.. For staging of H.C.C., we thus recommend to perform PET/CT with both tracers. (authors)

  15. Intra-arterial injection of lipid nano-capsules charged in rhenium-188, for the treatment of hepatocellular carcinomas among the rat; Injection intra-arterielle de nanocapsules lipidiques chargees en rhenium-188, pour le traitement des carcinomes hepatocellulaires chez le rat

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    Vanpouille, C.; Lacoeuille, F.; Hindre, F. [Inserm U646, Angers, (France); Roux, J. [service commun animalerie, hospitalo-universitaire, Angers, (France); Aube, C. [service de radiologie, CHU d' Angers, (France); Oberti, F. [service de gastro-enterologie et hepatologie, CHU d' Angers, (France); Lejeune, J.J.; Couturier, O. [service de medecine nucleaire, CHU d' Angers, (France)

    2009-05-15

    The objective of this study was to evaluate the therapy efficiency of the {sup 188}Re incorporated in the middle of lipid capsules (N.C.L. {sup 188}Re-S.S.S.) on a hepato carcinoma model of rat. The preliminary results are encouraging and show the efficiency of a single injection of N.C.L.{sup 188}Re-S.S.S. in a hepato carcinoma model of rat. (N.C.)

  16. Thyroid medullary carcinoma and PET/CT with {sup 18}F-DOPA in the post surgery follow up: preliminary results; Carcinome medullaire de la thyroide et TEP/TDM a la {sup 18}F-DOPA dans le suivi post-chirurgical: resultats preliminaires

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    Keomany, J.; Rust, E.; Constantinesco, A.; Imperiale, A. [CHU de Strasbourg, Service de biophysique et medecine nucleaire, 67 (France); Detour, J. [CHU de Strasbourg, Service de radiopharmacie, 67 (France); Chabrier, G.; Goichot, B. [CHU de Strasbourg, Service de medecine interne, endocrinologie et nutrition, 67 (France); Schneegans, O. [FNCLCC Paul-Strauss, 67 - Strasbourg (France)

    2010-07-01

    Purpose: to study the contribution of the PET/CT with {sup 18}F DOPA in the therapy follow-up of patients with a history of medullary thyroid carcinoma and biological suspicion of residual disease or recurrence. Conclusions: The preliminary results show the interest of the PET/CT with {sup 18}F DOPA in the therapy follow-up and the management of patients suffering of medullary thyroid carcinoma in biological relapse. (N.C.)

  17. Thyroid medullar carcinoma and therapy follow up with the help of PET/T.D.M. with {sup 18}F-DOPA: about four cases; Carcinome medullaire de la thyroide et suivi therapeutique a l'aide de la TEP-TDM a la 18F-DOPA: a propos de quatre cas

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    Imperiale, A.; Ben-sellem, D.; Keomany, J.; Constantinesco, A. [Biophysique et medecine nucleaire, CHU de Strasbourg, (France); Detour, J.; Beretz, L. [radiopharmacie, CHU de Strasbourg, (France); Chabrier, G.; Goichot, B. [medecine interne et nutrition, CHU de Strasbourg, (France)

    2009-05-15

    The objective was to study the contribution of the PET-T.D.M. to the dihydro phenylalanine labelled with {sup 18}F ({sup 18}F-DOPA) in the therapy follow up of patients with antecedents of thyroid medullar carcinomas and suspicion of biological recurrence. In spite of the very preliminary character of these results, these first cases show the interest of the PET-T.D.M. with {sup 18}F-DOPA in the therapy follow up and the coverage of patients reached by thyroid medullar carcinoma in biological recurrence. (N.C.)

  18. Significado clínico-patológico das expressões citofotométricas do Ki-67 e Caspase-3 no carcinoma de células escamosas do esôfago Clinicopathologic significance of the Ki-67 and Caspase-3 cytophotometric expressions in the esophageal squamous cell carcinomal

    Directory of Open Access Journals (Sweden)

    Gilmar Pereira Silva

    2008-06-01

    Full Text Available RACIONAL: A escolha da forma de tratamento do carcinoma de células escamosa de esôfago ainda hoje é orientada pelo estadiamento tumoral, onde as características histopatológicas do tumor são o maior determinante. Parale-lamente, desenvolvem-se estudos para entender o comportamento da biologia tumoral por método imunoistoquímico de quantificação manual, avaliando a ati-vidade proliferativa ou apoptótica do tecido em análise. As desvantagens conti-das no modo manual fizeram surgir e desenvolver método computadorizado de análise de imagem. OBJETIVOS: Verificar as expressões dos marcadores KI-67 e Caspase-3 e correlacioná-las com as características clínico-patológicas do tumor. MÉTODOS: Foram estudados 29 blocos parafinados provenientes de pa-cientes portadores de carcinoma de células escamosas de esôfago submetidos à esofagectomia e pertencentes a acervos de laboratórios de patologia. Proce-deu-se preparo das lâminas por técnica imunoistoquímica convencional. A quantificação da imunorreatividade às proteínas Ki-67 e Caspase-3 foi realizada pelo software de análise de imagem computadorizada SAMBA (Systeme d'Analyse Microphotometrique a Balayage Automatique através do índice de marcagem encontrado. RESULTADOS: Predominaram na amostra o sexo mascu-lino (82,7%; maiores de 50 anos; tumores moderadamente diferenciados (68,98%; estágio III (72,42%; lesões >3cm e localizadas no ⅓ inferior do ór-gão. Os índices médios de marcagem identificados foram de 62,05% para o Ki-67 e 86,06% para a Caspase-3, e não mostraram correlação com as caracterís-ticas clínico-patológicas como sexo, idade, estadiamento tumoral, grau de pro-fundidade da lesão e comprometimento linfonodal. Houve significante diferença de expressão do Ki-67 entre os graus histológicos (P=0,047 e correlação entre os índices dos marcadores estudados (r=0,41 e P =0,032. CONCLUSÃO: Na presente investigação as atividades das proteínas estudadas se mostraram in-tensas sendo que a da Caspase-3 foi superior ao Ki-67 mas sem correlação com as características clínico-patológicas.BACKGROUND: The esophageal squamous cell carcinoma treatment strategy is still based on the tumor staging, where tumor histopathologic charac-teristics are the major determinants. In parallel, studies have been developed in order to better understand the tumor biology using immunohistochemical meth-ods with manual quantification evaluating the proliferative and apoptotic activi-ties of the cells. The disadvantages related to the manual method rose the de-velopment of computerized ways to do the image analysis. OBJETIVES: To verify the expressions of the markers Ki-67 (proliferative and Caspase-3 (apoptotic and to correlate them with the clinic and pathologic characteristics of the tumor. METHODS: Twenty-nine paraffin embedded blocks were studied, each one con-taining tissue samples from patients with esophageal squamous cell carcinoma submitted to esophagectomies. The clinic and pathological data were obtained from histopathologic informations and from medical records. The slides were prepared following the routine immunohistochemical method until the point to utilize the specific antibodies (MIB-1 and CPP32. Positive quantification of the immunoreactivity to the proteins Ki-67 and Caspase-3 was performed by the software for computerized image analysis SAMBA (Systeme d' Analyse Micro-photometrique a Balayage Automatique. Statistical analysis was done having P3cm; and lesions located in the lower third of the organ. The mean score indexes found were 62.05% for Ki-67 and 86.06% for Caspase-3 and there was no correlation with the clinic or pathologi-cal characteristics as gender, age and tumor staging. There was significant dif-ference of Ki-67 expression among the histological grades (P=0.047 and corre-lation between the evaluated indexes (r=0.41 and P=0.032. CONCLUSION: The protein expressions were high and the Caspase-3 protein activity was higher than the Ki-67, without correlation with clinic or pathological characteristics as gender, age, tumor staging, grade of lesion depth and lymph node invasion.

  19. Tolerance and efficacy of conformal radiotherapy for hepatocellular carcinoma in cirrhotic patients. Results of the French RTF1 phase 2 trial; Tolerance et efficacite de la radiotherapie de conformation en cas de carcinome hepatocellulaire chez le patient cirrhotique. Resultats de l'essai de phase II RTF1

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    Mornex, F.; Girard, N.; Wautot, V.; Khodri, M. [Centre Hospitalier Lyon-Sud, Dept. de Radiotherapie-Oncologie, 69 - Pierre-Benite (France); Merle, P.; Kubas, A.; Trepo, C. [Hopital de l' Hotel-Dieu, Service d' hepatogastroenterologie, 69 - Lyon (France); Beziat, C. [Hopital de l' Hotel-Dieu, Dept. de Radiologie, 69 - Lyon (France)

    2005-11-15

    Purpose. - While some patients presenting with hepatocellular carcinoma (HCC) benefit from curative therapies (transplantation, surgery, percutaneous ablation), others are only candidates for palliative options such as chemo-embolization or symptomatic care. Although conventional external-beam radiotherapy of the liver is regarded as little efficient and potentially toxic in cirrhotic patients, 3-dimensional conformal radiotherapy (CRT), by decreasing the amount of normal liver included in the radiation portal, allows dose escalation to occur without increasing the risk of radiation-induced hepatitis. This trial was designed to assess the efficacy and tolerance of CRT for small-size HCC in cirrhotic patients. Patients and methods. - Prospective phase II trial including stage A/B cirrhotic patients with small-size HCC not suitable for curative treatments; CRT consisted in a standard fractionation radiation, with a total dose of 66 Gy. Results. - Twenty-seven patients were included, 15 of whom had previously been treated for HCC; mean age was 68. Among the 23 assessable patients, 18 (78%) presented with complete response, 3 (13%) with partial response, and 2 with no response. Acute complications occurred in 24 patients, and were mainly acceptable (grade 1/2: 22 patients, grade 3/4: 11 patients, 4 (15%) of whom had clinical and/or hematological toxicities). Only 2 (9%) grade 3/4 clinical and/or hematological late toxicities are reported. Conclusion. - CRT is a non-invasive curative technique highly suitable for small-size HCC in cirrhotic patients; further investigations are needed to compare it to the other available treatments, and to integrate it into the curative therapeutic algorithm of HCC. (author)

  20. Interest of the PET with F.D.G. in the evaluation of patients candidates to hepatic transplantation for hepatocellular carcinoma; Interet de la TEP au FDG dans l'evaluation des malades candidats a la transplantation hepatique pour carcinome hepatocellulaire

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    El Bez, I.; Hamza, F.; Yeddes, I.; Evangelista, E.; Meignan, M.; Itti, E. [CHU Henri-Mondor, Service de medecine nucleaire, 94 - Creteil (France); Decaens, T.; Duvoux, C. [CHU Henri-Mondor, Service d' hepato-gastroenterologie medecine nucleaire, 94 - Creteil (France); Luciani, A. [CHU Henri-Mondor, Service de radiologie, 94 - Creteil (France); Laurent, A. [CHU Henri-Mondor, Service de chirurgie digestive, 94 - Creteil (France)

    2010-07-01

    Purpose: the objective of this study was to evaluate the interest of PET with F.D.G. as predictive factor of progression and output of liver transplant list for hepatocellular carcinoma. Conclusions: These preliminary data show that the positivity of PET with F.D.G. is strongly associated to a output of liver transplant list for tumor progression. (N.C.)

  1. Metastatic calcifications of hyperparathyroidism detected by M.D.P.- Tc 99 m bone scintigraphy in patients with parathyroid carcinoma: A case report; Les calcifications metastatiques de l'hyperparathyroidie identifiees par scintigraphie osseuse au M.D.P.-Tc 99 m dans le cadre du carcinome parathyroidien: a propos d'un cas

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    Doudouh, A.; Biyi, A.; Oufroukhi, Y.; Zekri, A. [Hopital Militaire Mohammed-5, Service de Medecine Nucleaire, Rabat (Morocco); Sekkach, Y. [Hopital Militaire Mohammed-5, Service de Medecine B, Rabat (Morocco)

    2008-02-15

    The authors report a case of gastric, renal, pulmonary, and myocardial uptake of M.D.P.-Tc 99 m in a patient with parathyroid carcinoma. Parathyroid carcinoma is a rare cause of primary hyperparathyroidism which becomes complicated during its evolution by metastatic calcifications. Metastatic calcifications are frequently located in lungs and heart. If an adequate treatment is not undertaken, these calcifications progress and evolve into severe respiratory and cardiac complications. In our patient, quasi-complete disappearance of metastatic calcifications on the follow-up bone scintigraphy, performed four weeks after surgical cure of parathyroid tumour, indicates the great interest of this examination in early identification of metastatic calcifications and monitoring of their disappearance after treatment. (authors)

  2. Mediastinal radiotherapy after multidrug chemotherapy and prophylactic cranial irradiation in patients with SCLC - treatment results after long-term follow-up and literature overview; Radiotherapie mediastinale apres chimiotherapie et irradiation prophylactique de l'encephale chez des patients atteints d'un carcinome bronchique a petites cellules - Resultats et revue de la litterature

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    Herrmann, M.K.A.; Bloch, E.; Overbeck, T.; Wolff, H.A.; Hille, A.; Hess, C.F.; Christiansen, H. [Department of Radiotherapy, University Hospital Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (Germany); Koerber, W. [Department of Pneumology, Weende Hospital, Section Lenglern, Pappelweg 5, 37120 Bovenden-Lenglern (Germany); Vorwerk, H. [Department of Hematology and Oncology, University Hospital Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (Germany); Muller, M.; Pradier, O. [Department de cancerologie, CHU Morvan, 5, avenue Foch, 29200 Brest cedex (France)

    2011-04-15

    Introduction. - Curative therapy for patients with small-cell lung cancer (SCLC) is based on multidrug chemotherapy combinations and radiotherapy. After a long time follow-up, the aim of the study was to evaluate the efficacy and toxicity of sequential chemo-radiotherapy and the effect of prophylactic cranial irradiation (PCI). Methods. - From 1995-2005, 96 patients with SCLC (64 limited-disease [LD], 32 extensive-disease [ED]; median age 61 years [range 39-79]) were treated at our department with varying chemotherapy regimens and sequential mediastinal radiotherapy (50 Gy + 10 Gy boost in case of residual disease after chemotherapy). Afterwards, 15 patients with LD, good general condition and at least partial response after local treatment received PCI (30 Gy). Results. - After a median follow-up of 78.6 months, 20 patients remained alive (20.8%, median survival time 18.2 months). The 2-/5-year overall survival rates were 33.8% and 12.6%, the 2-/5-year loco-regional control rates were 30.3% and 24.5%, respectively. Distant metastases occurred in 43 patients (24 cerebral). Cerebral metastasis occurred in 6.7% and 27.2% of the patients with PCI and without PCI respectively. Only tumor stage showed a statistically significant impact on overall survival and loco-regional control in multivariate analysis. Radiotherapy was well tolerated. Grade 3/4 toxicity occurred in seven patients. Prognosis of patients with SCLC remains poor. Administration of PCI in selected patients bears a decrease in the incidence of cerebral metastases. Alternative chemotherapy schemes as well as irradiation schemes and techniques should be the substance of future randomized trials. (authors)

  3. Whole brain radiation with supplementary boost for patients for unique brain metastasis from a primitive lung cancer; Experience de l'irradiation encephalique totale avec escalade de dose focalisee pour le traitement des metastases cerebrales uniques d'un carcinome bronchopulmonaire

    Energy Technology Data Exchange (ETDEWEB)

    Levy, A.; Lamproglou, I. [Service de radiotherapie, groupe hospitalier Pitie-Salpetriere, 47-83, boulevard de l' Hopital, 75013 Paris (France); Chargari, C. [Service de radiotherapie, groupe hospitalier Pitie-Salpetriere, 47-83, boulevard de l' Hopital, 75013 Paris (France); Service de radiotherapie, hopital d' instruction des armees Val-de-Grace, 75005 Paris (France); Mazeron, J.J. [Service de radiotherapie, groupe hospitalier Pitie-Salpetriere, 47-83, boulevard de l' Hopital, 75013 Paris (France); Universite Pierre-et-Marie-Curie Paris 6, 4, place Jussieu, 75005 Paris (France); Krzisch, C. [Service de radiotherapie, CHU d' Amiens-Picardie, place Victor-Pauchet, 80054 Amiens cedex (France); Assouline, A. [Service de radiotherapie, groupe hospitalier Pitie-Salpetriere, 47-83, boulevard de l' Hopital, 75013 Paris (France); Universite Pierre-et-Marie-Curie Paris 6, 4, place Jussieu, 75005 Paris (France); Service de radiotherapie, CHU d' Amiens-Picardie, place Victor-Pauchet, 80054 Amiens cedex (France)

    2011-08-15

    Purpose. - To assess the potential benefit of a boost in patients treated with whole brain irradiation by a conventional linear accelerator for lung cancer solitary brain metastasis. Patients and methods. - From 2002 to 2006, a retrospective analysis was carried out from 64 unselected consecutive patients with secondary brain metastasis from lung cancer, treated with whole brain irradiation without surgical resection. Thirty patients (47%) received a boost in their brain metastases. Three potential prognostic factors were studied: sex, RPA score and improvement of neurological symptoms after radiotherapy. An analysis was conducted to determine whether an additional dose may improve survival in the absence of surgical resection. Results. - The mean follow-up was 4.9 months. The median overall survival was 8.5 months (6.4 to 10.7 months). The total dose of radiotherapy was the only significant prognostic factor for overall survival. The median overall survival was 6.2 months for patients without additional radiation versus 11.2 months for patients receiving a boost dose (p = 0.011). Sex, RPA score and improvement of neurological symptoms after radiotherapy were not found as prognostic factors for overall survival. Conclusions. - Boost delivered after whole brain radiation therapy by a conventional particle accelerator may provide a benefit in selected patients, especially for centres that do not have radiotherapy techniques in stereotactic conditions. This warrants further prospective assessment. (authors)

  4. Translation of the Department of Defense Disease and Injury Codes to the Eighth Revision International Classification of Diseases for use by the Military Services.

    Science.gov (United States)

    1976-06-01

    Example: DDDIC ICDA-8 NHRC Code Ntmuber Code Number Code Number Disease Entity Desivnator 5000 08-467-01 Hypertrophy of tonsils and adenoids ...Unspecified with regard to surgical treatment 5100 08-467-02 Hypertrophy of tonsils and adenoids / Without mention of tonsillectomy or adenoidectomy 5101 08-467...03 Hypertrophy of tonsils and adenoids / With tonsillectomy or adenoidectomy 5110 5010 08-468-01 Peritonsillar abscess/All types 5120 5020 08-469-01

  5. NS-398, a selective cyclooxygenase-2 inhibitor, reduces experimental bladder carcinoma outgrowth by inhibiting tumor cell proliferation.

    NARCIS (Netherlands)

    Smakman, N.; Schaap, N.P.M.; Snijckers, C.M.; Rinkes, M.J.; Kranenburg, O.

    2005-01-01

    OBJECTIVES: To evaluate the efficacy of the selective cyclooxygenase-2 (COX-2) inhibitor NS-398 in treating experimental T24 bladder carcinoma, and to assess its effect on tumor cell proliferation and survival and tumor vascularization. COX-2 overexpression is frequently observed in bladder carcinom

  6. Lung-MAP Launches: First Precision Medicine Trial From National Clinical Trials Network

    Science.gov (United States)

    A unique public-private collaboration today announced the initiation of the Lung Cancer Master Protocol (Lung-MAP) trial, a multi-drug, multi-arm, biomarker-driven clinical trial for patients with advanced squamous cell lung cancer. Squamous cell carcinom

  7. Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: study of 27 cases in 500 patients

    DEFF Research Database (Denmark)

    von der Maase, H; Rørth, M; Walbom-Jørgensen, S

    1986-01-01

    Carcinoma in situ in the contralateral testis was diagnosed in 27 of 500 patients (5.4%) with unilateral testicular germ cell cancer. Eight of the 27 patients received intensive chemotherapy for spread of their initial testicular cancer. Follow up biopsy studies did not detect changes of carcinom...

  8. [Muscular metastases. A case report (author's transl)].

    Science.gov (United States)

    Trèves, R; Barruche, D; Desproges-Gotteron, R

    Muscular metastases are exceptionally reported. The authors present a case of crural neuralgia in relation with a localisation in the psoas iliacus of a gastric carcinoma. A review of literature defines the rarity of this facts (156 cases) the etiology (carcinome more often) and the explication who is still obscur.

  9. FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma

    NARCIS (Netherlands)

    Koole, Koos; van Kempen, Pauline M W; van Bockel, Liselotte W.; Smets, Timo; van der Klooster, Zoë; Dutman, Annemiek C.; Peeters, Ton; Koole, Ron; van Diest, Paul; van Es, Robert J. J.; Willems, Stefan M.

    2015-01-01

    Objective: The aim of this study was to investigate whether fibroblast growth factor receptor 4 (FGFR4) could serve as a potential therapeutic target, prognostic biomarker or biomarker predicting radiotherapy sensitivity in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinom

  10. 层粘连蛋白及其受体在涎腺腺样囊性癌表达的意义%Expression of laminin and laminin receptor in adenoid cystic carcinoma of salivary gland

    Institute of Scientific and Technical Information of China (English)

    李萍; 宋琦; 谢文扬; 陈志芳

    2005-01-01

    目的:研究涎腺腺样囊性癌中层粘连蛋白(laminin,LN)及其受体(laminin receptor,LN-R)表达特征及其与腺样囊性癌的某些临床病理指标的关系.方法:用超敏S-P免疫组化方法检测34 例涎腺腺样囊性癌LN和LN-R的表达.结果:LN-R的表达与涎腺腺样囊性癌组织分型、临床分期有关(P0.05).结论:LN及其受体LN-R的表达可作为涎腺腺样囊性癌恶性程度的一个指标.

  11. The effect of the operation under nasal endoscopy in treatment of child adenoid vegetation%鼻内窥镜下手术治疗儿童腺样体肥大的效果

    Institute of Scientific and Technical Information of China (English)

    罗征; 任海棠

    2006-01-01

    局麻或全麻下对儿童腺样体肥大患儿使用鼻内窥镜经鼻或经口行腺样体切除术,治疗由腺样体肥大引起的鼻堵、睡眠呼吸障碍和由咽鼓管引流障碍引起的分泌性中耳炎等,均获得良好效果.鼻内窥镜直视下腺样体切除术,鼻咽部结构暴露清晰,手术创面小,损伤小,出血少,病变切除彻底,无残留,无明显并发症.

  12. CLINICAL SIGNIFICANCE OF DETERMINING PLASMA SOLUBLE P-SELECTIN IN PATIENTS WITH PAROTID ADENOID CYSTIC CARCINOMA%腮腺腺样囊性癌病人血浆P-选择素的测定

    Institute of Scientific and Technical Information of China (English)

    蔡圳; 李宁毅; 樊功为; 童庆春; 陈万涛; 卜令学

    2001-01-01

    ①目的探讨可溶性P-选择素(sP-selectin)与腮腺腺样囊性癌发展及转移的关系.②方法用ELISA法检测65例腮腺腺样囊性癌病人血浆中sP-selectin的含量.③结果腮腺腺样囊性癌病人血浆中sP-selectin的含量均明显高于正常对照组(t=-12.65,P<0.01);而且血浆中sP-selectin的水平与病情发展有关(F=92.67,q=5.602~13.453,P<0.01).④结论 sP-selectin检测有可能成为腮腺腺样囊性癌病人辅助诊断、观察病情发展的一项有价值的指标.

  13. Slit-Robo信号在涎腺腺样囊性癌嗜神经侵袭中的表达和意义%Expression and significance of Slit/Robo signal in salivary adenoid cystic carcinoma

    Institute of Scientific and Technical Information of China (English)

    贾江; 刘兰忠; 钱震; 韩冰; 刘冠花; 王丽京

    2005-01-01

    目的:了解涎腺腺样囊性癌(SACC)中Slit蛋白和其受体Robo的表达并探讨其在肿瘤嗜神经侵袭中的意义.方法:对34例SACC进行组织分型、嗜神经性分组,同时应用免疫组化方法,对SACC中Slit/Robo的表达进行检测.结果:有嗜神经现象、临床复发的SACC病例中Slit/Robo的表达较无嗜神经现象、临床无复发的病例显著升高(P<0.05).结论:Slit/Robo在不同分组SACC中均存在不同程度的阳性表达.Slit/Robo与SACC的嗜神经性、临床复发具有密切关系.

  14. The expression and significance of BDNF and TrkB in salivary adenoid cystic carcinoma%BDNF和TrkB在唾液腺腺样囊性癌中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    苏立新; 张陈平; 胡永杰; 周晓健; 叶金海; 李思毅

    2006-01-01

    目的:观察BDNF和TrkB在唾液腺腺样囊性癌组织和细胞系中的表达,揭示BDNF和TrkB与唾液腺腺样囊性癌高转移特性和神经侵袭特性的关系.方法:以30例SACC标本为研究对象,以5例正常腮腺及3例腺泡细胞癌作为对照,采用免疫组化法对BDNF和TrkB进行检测.以SACC高、低转移细胞系ACC-2和ACC-M为研究对象,利用免疫组化、RT-PCR、实时荧光定量PCR和Western印迹,检测BDNF和TrkB在其中的表达差异.采用χ2检验进行统计学分析.结果:组织标本免疫组化显示:TrkB表达水平在嗜神经现象组显著高于未见嗜神经现象组(P<0.05),BDNF表达水平与嗜神经现象无关(P>0.05).实时荧光定量PCR和Western印迹均检测到BDNF和TrkB在ACC-M中的表达高于ACC-2(P<0.01).结论:TrkB的表达强度与SACC的神经侵袭特性相关,BDNF和TrkB的表达强度与SACC的高转移特性相关.

  15. CT diagnostic and analysis of adenoid cystic cancinoma of the nasal cavity and paranasal sinus%鼻及鼻旁窦腺样囊性癌CT诊断分析

    Institute of Scientific and Technical Information of China (English)

    王荣刚

    2010-01-01

    目的:分析鼻及鼻旁窦腺样囊性癌(ACC)的CT表现及临床价值.方法:回顾性分析鼻及鼻旁窦ACC 13例患者资料,其中8例手术,5例为病理穿刺活检证实并行放射治疗,结合临床病理,观察CT表现.结果:肿瘤起源于上颌窦8例,起源于鼻腔4例,起源于筛窦1例.侵犯邻近结构包括筛窦、碟窦、鼻腔、颞下窝、翼腭窝、齿槽骨、眼眶及颅底等.Ⅱ期1例,Ⅲ期2例,Ⅳ期10例,邻近骨质呈膨胀性骨改变5例,侵蚀性破坏3例,二者兼有者5例,肿瘤形态不规则呈无定形性生长7例,瘤内可见多发斑片状的低密度区占84.6%.结论:鼻及鼻旁窦ACC呈低密度筛孔样改变,浸润不规则生长,沿神经蔓延,有膨胀性及侵蚀性骨破坏.

  16. Gene KAI1 and Tiam1's expression and significance in salivary adenoid cystic carcinoma%基因KAI1和Tiam1在涎腺腺样囊性癌中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    刘屹嵩; 魏冰; 闫征斌; 王天祥; 柳宏志

    2012-01-01

    目的 检测KAI1和Tiam1在腺样囊性癌(ACC)组织和正常涎腺组织中的表达,探讨二者与ACC分期、肿瘤直径及淋巴结转移、患者年龄、性别的相关性.方法 应用免疫组织化学方法检测40例ACC组织和正常涎腺组织中KAI1和Tiam1的表达.结果 ACC组织中KAI1阳性表达率显著低于正常涎腺组织,而ACC组织中Tiam1阳性表达率显著高于正常涎腺组织 ;KAI1和Tiam1表达均与TNM分期、肿瘤直径及淋巴结转移有关,而与患者年龄、性别无关.结论 KAI1和Tiam1异常表达与ACC的发生、转移及预后密切相关,联合检测KAI1和Tiam1的表达有望成为ACC的早期诊断、预后评估的分子指标,为进一步探讨涎腺腺样囊性癌的致病机制及意义提供了理论基础和实验依据.

  17. 腺样囊性癌组织中增殖细胞核抗原标志物的表达及其意义%Expression of Ki-67 in adenoid cystic carcinoma and its significance

    Institute of Scientific and Technical Information of China (English)

    陈琦; 农晓琳; 曹阳

    2007-01-01

    目的:探讨增殖细胞核抗原标记物(Ki-67)在腺样囊性癌(ACC)组织中的表达情况及其意义.方法:采用免疫组织化学S-P法测定Ki-67在54例ACC组织中的表达情况,t检验统计分析其临床及病理学意义.结果:Ki-67在ACC组织中的表达与临床分期及病理类型有关,Ki-67的高表达预示着ACC的预后较差.结论:Ki-67可作为判断ACC恶性程度及预后的有效指标.

  18. siRNA干扰survivin表达对腺样囊性癌细胞株ACC-M的抑制作用%Inhibitory effect of RNAi-mediated survivin gene in adenoid cystic carcinoma cells lines ACC-M

    Institute of Scientific and Technical Information of China (English)

    汪欣; 杨军; 许波; 熊宇; 张从纪

    2008-01-01

    目的 探讨靶向survivin基因RNAi对腺样囊性癌增殖的抑制效应.方法 设计、合成siRNA(small interferingRNA),构建表达载体pGenesil-shRNA-survivin,将重组质粒导入人腺样囊性癌ACC-M细胞株.采用逆转录-聚合酶链反应(RT-PCR)、Western-blot法分别检测转染后的ACC-M细胞中survivin mRNA和蛋白表达的变化,用噻唑蓝(MTT)法来检测细胞的增殖.结果 测序证实表达载体构建成功,在pGenesil-shRNA-survivin的ACC-M细胞株中,survivin mRNA及蛋白表达明显降低,ACC-M细胞增殖受到抑制.结论 pGenesil-shRNA-survivin重组质粒能有效抑制腺样囊性癌细胞增殖.

  19. Analysis of the role of the gene coding the Amyloid-Precursor Protein Binding Protein 1 (APP-BP1) in the radio-sensitivity of epidermoid carcinomas of the upper aero-digestive tract infected by the human papillomavirus; Analyse du role du gene codant l'Amyloid-Precursor Protein Binding Protein 1 (APP-BP1) dans la radiosensibilite des carcinomes epidermoides des voies aero-digestives superieures infectees par le papillomavirus humain

    Energy Technology Data Exchange (ETDEWEB)

    Guihard, S.; Altmeyer, A.; Ramolu, L.; Macabre, C.; Abecassis, J.; Noel, G.; Jung, A.C. [Centre de lutte contre le cancer Paul-Strauss, 67 - Strasbourg (France)

    2010-10-15

    As the human papillomavirus (HPV) is at the origin of 25% of upper aero-digestive tract cancers, and as these tumours present an increased radio-sensitivity compared to other tumours, probably due to a greater transcriptional activity of p53, the authors report the study on the influence of a decrease of the expression of the APP-BP1 in these tumours which could favour a radio-induced apoptosis. By using a reverse transcriptase polymerase chain reaction (RT-PCR), they assessed the APP-BP1 expression levels as well as expression levels of transcriptions coding onco-proteins known to be over-expressed in HPV+ tumours. They compared the radio-sensitivities of HPV+ and HPV- cells, the first one appearing to be greater than the second one. Short communication

  20. Paediatric adenoidectomy: endoscopic coblation technique compared to cold curettage.

    Science.gov (United States)

    Di Rienzo Businco, L; Angelone, A M; Mattei, A; Ventura, L; Lauriello, M

    2012-04-01

    The aim of our study was to assess the efficacy and safety of endoscopic coblator adenoidectomy compared to cold curettage in paediatric patients. Forty homogeneous children (4-16 years of age) with adenoid hypertrophy were divided in 2 groups to receive adenoidectomy using cold curettage (A) or coblator (B). After surgery the following outcomes were evaluated: pain score on first day, days reporting pain, analgesic days, liquid diet days, absent from school days, pain score, days with nausea, days with fever, endoscopic adenoid grade and intraoperative bleeding. Forty days after surgery, basal rhinomanometry and nasal decongestion test were measured. The coblation group reported significantly less pain on the first post-operative day, days reporting pain, analgesic days, liquid diet days and absent school days. Patients in group A showed a higher grade of adenoid persistence by rhinoendoscopy, with high values of nasal resistances at the rhinomanometry even after nasal decongestion, consistent with greater adenoid persistence after cold curettage causing air flow obstruction even after turbinate decongestion. Intra-operative bleeding during coblation was significantly less compared the group undergoing cold curettage. Coblator treatment significantly improved patient recovery compared to curettage. Endoscopic coblation adenoidectomy ensures complete removal of adenoids and reduces postoperative adenoid grade. It can also be considered safer because it is under endoscopic control and can reach the cranial portion of the adenoid and its intranasal extension.

  1. A Comparative Study of the Lengths of Stay of Matched Groups of Inpatients Treated in Civilian, United States Army, Navy, and Air Force Hospitals

    Science.gov (United States)

    1974-03-01

    Comparison of the Four Health Care Systems (Non- active Duty) 106 38 Hypertrophy of Tonsils and Adenoids -- Percentage of Patients Discharged by Day...A Comparison of the Four Health Care Systems (Active Duty) 107 39 Hypertrophy of Tonsils and Adenoids -- Percentage of Patients Discharged by Day; A...Pnuemonia, 480.0-486.0 Pneumonia except Viral 493.0 Asthma 493.0-493.9 Asthma 500.0 Hypertrophy of Ton- 500.0 Hypertrophy of Ton- sils and Adenoids sils and

  2. Variability in Deposition Rates and Mean Days of Hospitalization for the 100 Most Common Diagnostic Codes in U.S. Army Health Services Command Facilities.

    Science.gov (United States)

    1992-06-02

    example, Code 4741 Hypertrophy of Tonsils and Adenoids is relatively specific 4.e., denotes a single, uniform diagnosis) and shows a high degree of...5 56 A 26 91 22.75 8 6442 EARLY ONSET DELIVERY (#3?KS) 27 zi 43 98 24.50 9 4741 HYPERTROPHY TONSILS/ ADENOIDS 29 _2 17 33 101 25.25 10 6633 UMBILICAL...34SPEC PREECLRMPSIA 28 60 40 10 138 34.50 29 600 HYPERPLASIR OF PROSTATE 7: 39 19 34 143 35.75 29 4741 HYPERTROPHY TONSILS/ ADENOIDS 49 36 13 45 143 35.75

  3. Endometrioid ovarian carcinoma during pregnancy presenting with acute rupture.

    Science.gov (United States)

    Gottheil, Stephanie; McGee, Jacob

    2013-11-01

    Contexte : Le carcinome endométroïde de l’ovaire est rarement diagnostiqué pendant la grossesse et est généralement asymptomatique. Nous faisons état d’un cas de carcinome endométroïde de l’ovaire pendant la grossesse ayant présenté une rupture aiguë et nous discutons des options de prise en charge. Cas : Une primigravide présentait, à 26 semaines de gestation, de graves douleurs abdominales. Au moment de la laparotomie, nous avons constaté la présence d’une masse annexielle ayant connu une rupture. Cette masse a postopératoirement été identifiée comme étant un carcinome endométroïde de l’ovaire. En vue de maximiser les issues maternelles et fœtales, nous avons pris la décision de procéder, à 34 semaines, à une césarienne au moyen d’une prise en charge chirurgicale permettant de sauvegarder la fertilité. Conclusion : À notre connaissance, il s’agit du premier cas signalé de carcinome endométroïde de l’ovaire présentant une rupture pendant la grossesse. En présence de graves douleurs abdominales pendant la grossesse, le diagnostic différentiel devrait inclure la rupture d’une tumeur ovarienne maligne.

  4. Masse rénale avec image stellaire centrale: Quel est votre diagnostic?

    Directory of Open Access Journals (Sweden)

    A. Qarro

    2013-03-01

    Full Text Available Le carcinome chromophobe se voit essentiellement à la cinquième décennie et représente 5% des tumeurs rénales. Il existe deux sous types de cancer à cellules chromophobes: le type clair (70% et le type éosinophile. La variante à cellules éosinophiles doit être distinguée de l'oncocytome. Ce dernier se caractérise par une cicatrice fibreuse centrale d'aspect stellaire. Le carcinome chromophobe et l'oncocytome peuvent même coexister dans le cadre du syndrome de Birt-Hogg-Dubé. Certaines tumeurs appelées hybrides partagent des caractéristiques architecturales et cytologiques de ces deux tumeurs. Le pronostic du carcinome chromophobe est favorable. Il est le plus souvent limité au rein et de bas grade nucléaire. Il semblerait donc licite dans les cas ou un examen extemporané mettrait en évidence une tumeur chromophobe, de limiter l'intervention à une néphrectomie partielle si techniquement réalisable.

  5. Orofacial Myofunctional Disorders

    Science.gov (United States)

    ... include the following: increasing awareness of mouth and facial muscles increasing awareness of mouth and tongue postures improving muscle strength and coordination improving speech sound productions improving swallowing patterns If airways are blocked due to enlarged tonsils and adenoids ...

  6. Parotid carcinoma

    DEFF Research Database (Denmark)

    Sørensen, Kristine Bjørndal; Godballe, Christian; de Stricker, Karin;

    2006-01-01

    OBJECTIVES: Our aim is to investigate the expression of kit protein (KIT) and epidermal growth factor receptor (EGFR) in parotid carcinomas in order to correlate the expression to histology and prognosis. Further we want to perform mutation analysis of KIT-positive adenoid cystic carcinomas....... PATIENTS AND METHODS: Formalin-fixed paraffin-embedded sections from 73 patients with parotid gland carcinomas were used for the study. The sections were stained with both KIT and EGFR polyclonal antibodies. Twelve KIT-positive adenoid cystic carcinomas were examined for c-kit mutation in codon 816....... RESULTS: Of all carcinomas 25% were KIT-positive and 79% were EGFR-positive. Ninety-two percentage of the adenoid cystic carcinomas were KIT-positive. None of the adenoid cystic carcinomas had mutations in codon 816 of the c-kit gene. CONCLUSION: Neither KIT- nor EGFR-expression seem to harbour...

  7. Tonsillitis: MedlinePlus Health Topic

    Science.gov (United States)

    ... Sore Throat, Strep, and Tonsillitis (American Academy of Pediatrics) Also in Spanish My Child Has Tonsillitis. Will He Need to Have His Tonsils Removed? (American Academy of Pediatrics) Also in Spanish Tonsils and Adenoids (American Academy of Otolaryngology--Head ...

  8. Instructional Methods for Human Anatomy and Cell Biology in Nurse Anesthesia Graduate Programs: A Survey with a Focus on Regional Anesthesia

    Science.gov (United States)

    1997-09-01

    physiological effects of sectioning the spinal cord at various levels. He proved that cutting the recurrent laryngeal nerve caused loss of voice, and...Oropharyngeal (1) Endoscopy (2) Fractures (3) Tonsils and adenoids/Peritonsilar abscess (4) Orthodontic /Dental (5

  9. Tonsillitis

    Science.gov (United States)

    ... around the tonsils Kidney disease caused by strep Rheumatic fever and other heart problems When to Contact a ... abscess Pharyngitis - sore throat Post-streptococcal glomerulonephritis (GN) Rheumatic fever Patient Instructions Tonsil and adenoid removal - discharge Review ...

  10. What Is Acute Lymphocytic Leukemia (ALL)?

    Science.gov (United States)

    ... Lymphoid tissue is found in lymph nodes, the thymus, the spleen, the tonsils and adenoids, and is ... destroy some germs by surrounding and digesting them. Development of leukemia Any type of early blood-forming ...

  11. What Is Hodgkin Disease?

    Science.gov (United States)

    ... blood cells, and platelets are made. Thymus: The thymus is a small organ behind the upper part of the breastbone and in front of the heart. It is important in the development of T lymphocytes. Adenoids and tonsils: These are ...

  12. Non-Hodgkin's Lymphoma

    Science.gov (United States)

    ... These include the lymphatic vessels, tonsils, adenoids, spleen, thymus and bone marrow. Occasionally, non-Hodgkin's lymphoma involves ... understand the possible link between pesticides and the development of non-Hodgkin's lymphoma. Older age. Non-Hodgkin's ...

  13. Drug: D06965 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available adenoiditis; Ecozema in childhood Therapeutic category: 5200 Therapeutic category of drugs in Japan [BR:br08...Trichosanthes root [DR:D06701], Burdock fruit [DR:D06723], Glycyrrhiza [DR:D04365] Nervous disease; Chronic

  14. A Case Report of Left-Sided Headache with Rhinocleisis

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Case Report A patient, with a complaint of a left-sided headache plus a rhinocleisis for a month, was admitted to our hospital. The clinical diagnosis showed that it was a primary adenoid cystic carcinoma (ACC) of the nasopharynx.

  15. Acetaminophen and Codeine

    Science.gov (United States)

    ... had surgery to remove their tonsils and/or adenoids.In April 2015, the European Medicines Agency (EMA) ... history of alcoholism, lung or thyroid disease, prostatic hypertrophy, or urinary retention.tell your doctor if you ...

  16. Tonsillectomy - series (image)

    Science.gov (United States)

    ... period, or upper airway obstruction due to tonsillar hypertrophy recurrent tonsillar abscess Tonsillectomy is advised if the tonsils are enlarged and obstructing access to the adenoid during an adenoidectomy operation, or the physician suspects ...

  17. Associations between adenotonsillar hypertrophy, age, and obesity in children with obstructive sleep apnea.

    Directory of Open Access Journals (Sweden)

    Kun-Tai Kang

    Full Text Available OBJECTIVE: To investigate the contributions of adenoid and tonsil size to childhood obstructive sleep apnea (OSA and the interactions between adenotonsillar hypertrophy, age, and obesity in children with OSA. METHODS: In total, 495 symptomatic patients were recruited. The patients were assigned to four groups according to age: toddler (age 1-3, n=42, preschool (age 3-6, n=164, school (age 6-12, n=200, and adolescence (age 12-18, n=89. All subjects had tonsil size graded by otolaryngologists, adenoid size determined on lateral radiographs (Fujioka method, and a full-night polysomnography. The apnea-hypopnea index (AHI, adenoid size, and tonsil size were compared in obese and non-obese children in the four age groups. Adjusted odds ratios (ORs and 95% confidence interval (CI of adenotonsillar hypertrophy and OSA risk were estimated by multi-logistic regression. RESULTS: The AHI was positively related to tonsil grade (r=0.33, p <0.001 and adenoid size (r=0.24, p <0.01 in all patients. Tonsil grade was positively related to AHI in all four age groups. Adenoid size was positively related to AHI in the toddler, preschool, school groups, but not in the adolescent group (r=0.11, p=0.37. Tonsil grade and adenoid size were both positively related to AHI in obese and non-obese children. In the regression model, obesity (OR=2.89; 95% CI 1.47-5.68, tonsillar hypertrophy (OR=3.15; 95% CI 2.04-4.88, and adenoidal hypertrophy (OR=1.89; 95% CI 1.19-3.00 significantly increased OSA risk. CONCLUSIONS: Adenotonsillar hypertrophy and obesity are the major determinants of OSA in children. However, the influence of adenoid size decreases in adolescence.

  18. 腺样囊性癌组织中肌上皮细胞标记物α-SMA 与雪旺氏细胞标志物 Leu -7的共同表达%Coepression of myoepithelial cell marker α-SMA and Schwann cell marker Leu -7 insalivary adenoid cystic carcinoma

    Institute of Scientific and Technical Information of China (English)

    谢耕耘; 杨建智

    2015-01-01

    目的:检测肿瘤性肌上皮细胞标记物α-SMA 与雪旺细胞标记物 Leu -7在 ACC 中的表达。方法:免疫组织化学法检测 ACC 与粘液表皮样癌细胞中肌上皮细胞标记物α-SMA 蛋白与雪旺细胞标记物 Leu -7蛋白在病理切片中的表达。结果:Leu -7蛋白及 a -SMA 蛋白在 ACC 中存在共表达现象,提示二者分布在同种细胞中。结论:在 ACC 中 Leu -7蛋白及 a -SMA 蛋白存在共表达现象。%objective:Detection expression of myoepithelial cell marker α-SMA and the Schwann cell marker Leu -7 in the ACC.Methods:Immunohis-tochemical Detection expression of the myoepithelial cell marker α-SMA protein and Schwann cell marker Leu -7 protein in ACC and mucoepidermoid carcino-ma.Result:In the ACC both were observed phenomenon of tumor cells perineural invasion.Conclusion:ACC organizations has existed Schwann cell differenti-ation of the tumor cells.

  19. Coexpression of Schwann cell marker Leu-7 and myoepithelial cell marker α-SMA in salivary adenoid cystic carcinoma%雪旺细胞标记物Leu-7与肌上皮细胞标记物α-SMA在涎腺腺样囊性癌中共表达

    Institute of Scientific and Technical Information of China (English)

    陈伟; 刘宝林; 孙沫逸; 陈丹; 居云

    2008-01-01

    目的:检测雪旺细胞标记物Leu-7与肌上皮细胞标记物α-SMA在涎腺腺样囊性癌(ACC)中的表达情况,并探讨Leu-7、α-SMA与ACC嗜神经侵袭的关系.方法:利用免疫组织化学、免疫荧光双标记及激光共聚焦显微镜技术检测Leu-7蛋白与α-SMA蛋白在涎腺腺样囊性癌组织中的表达.结果:在涎腺腺样囊性癌组织中,Leu-7蛋白与α-SMA蛋白均有表达,二者在同一肿瘤性肌上皮样细胞胞质中共表达.结论:腺样囊性癌中肿瘤性肌上皮样细胞发生雪旺细胞分化进而侵袭神经可能是腺样囊性癌嗜神经侵袭的病理组织学基础.

  20. Influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma (SACC) - 83 and SACC-LM cells%特异性抑制剂对腺样囊性癌细胞中蛋白激酶B表达的影响

    Institute of Scientific and Technical Information of China (English)

    杨鸣良; 沈磊; 孙长伏

    2006-01-01

    目的探讨特异性抑制剂LY294002对体外培养涎腺腺样囊性癌(SACC)细胞中蛋白激酶B(PKB)表达和转录水平的影响.方法经细胞培养后,应用Wester-blot和RT-PCR实验技术,用酶显法显色、EB染色,将实验数据进行配对t检验.结果SACC-83细胞PKB丝氨酸473(Ser473)的表达和转录水平显著低于SACC-LM细胞PKB(Ser473)的表达和转录水平(P<0.05);而经LY294002处理的细胞PKB(Ser473)的表达显著低于未经处理细胞PKB(Ser473)的表达(P<0.01),但两者转录水平差异无统计学意义(P>0.05).结论体外培养的SACC-83细胞PKB(Ser473)的蛋白表达和转录水平显著低于SACC-LM细胞;LY294002对体外培养细胞中的PKB(Ser473)蛋白表达有明显抑制作用.

  1. BDNF/TrkB在唾液腺腺样囊性癌上皮-间质转化过程中的表达及意义%Expression of BDNF/TrkB in the progress of epithelial-mesenchymal transition in salivary adenoid cystic carcinoma

    Institute of Scientific and Technical Information of China (English)

    胡志强; 杨新杰; 王维玺; 贾森; 吴宝磊; 雷德林

    2015-01-01

    目的:研究BDNF,TrkB和E-cadherin在唾液腺腺样囊性癌(SACC)细胞系中的表达,初步探讨BDNF、TrkB和E-cadherin与SACC高转移性及神经侵袭性之间的关系.方法:以SACC高、低转移细胞系SACC-LM和SACC-83为研究对象,利用实时荧光定量PCR和Western免疫印迹技术检测BDNF、TrkB和E-cadherin在其中的表达差异;在SACC-83细胞系中加入外源性BDNF因子、TrkB抑制剂k252a,分析BDNF/TrkB通路在SACC侵袭转移过程中的生物学作用;利用实时荧光定量PCR、Western免疫印迹、细胞形态观察、细胞迁徙和侵袭实验评估SACC细胞上皮-间质转化(EMT)进程.应用SPSS17.0软件包对数据进行统计学处理.结果:BDNF和TrkB在SACC-LM中的表达高于SACC-83,E-cadherin在SACC-LM中的表达低于SACC-83;外源性BDNF刺激能有效诱导TrkB的激活和表达,降低E-cadherin的表达,提高N-cadherin的表达,使细胞形态呈长梭形改变,促进SACC-83细胞的迁徙、侵袭能力;而TrkB受体抑制剂k252a可有效抑制BDNF的各种作用,降低SACC-83细胞形态变化和迁徙、侵袭能力.结论:BDNF/TrkB信号通路通过介导SACC的EMT过程,促进SACC的迁徙、侵袭能力.

  2. 酪氨酸激酶A在涎腺腺样囊性癌中的表达及与嗜神经侵袭的关系%Tyrosine kinase A expression correlates with perineural invasion in salivary adenoid cystic carcinoma

    Institute of Scientific and Technical Information of China (English)

    王磊; 孙沫逸; 杨耀武; 程晓兵; 李建虎

    2004-01-01

    检测酪氨酸激酶A(TrkA)在涎腺腺样囊性癌(ACC)中的表达情况,研究TrkA与ACC嗜神经侵袭的关系.方法:研究对象为33例ACC,7例正常腮腺及3例涎腺腺泡细胞癌标本,采用免疫组化法对组织切片中的TrkA进行检测.结果:以病理学表现为标准,33例ACC中的嗜神经侵袭率为45.5%(15/33),TrkA阳性率为97.0%(32/33),且发现沿神经周分布的肿瘤细胞的染色强度明显高于远离神经者.存在嗜神经现象组的TrkA表达水平明显高于未见嗜神经现象组(P<0.01).TrkA的表达在腺泡细胞癌胞浆内均为阴性,而在正常腮腺的导管细胞为阳性.结论:TrkA可能作为ACC嗜神经侵袭的生物学标志.TrkA表达的增高可能是ACC嗜神经侵袭的机理之一.

  3. Effect of SD rat sciatic nerve on proliferation of Adenoid Cystic Carcinoma Cell Line ACC-M in vitro%SD大鼠坐骨神经对腺样囊性癌细胞系ACC-M体外增殖能力的影响

    Institute of Scientific and Technical Information of China (English)

    杨向明; 孙沫逸; 蔡卜磊; 贾文荣; 李建虎

    2010-01-01

    目的:研究SD大鼠坐骨神经对腺样囊性癌ACC-M细胞体外增殖能力的影响.方法:将人腺样囊性癌细胞系(ACC-M)分别与条件培养液和坐骨神经培养液共培养24、48、72h.应用MTT比色法研究SD大鼠坐骨神经对腺样囊性癌ACC-M细胞体外增殖能力的影响.结果:坐骨神经培养液对ACC-M作用48和72h后,ACC-M细胞的增殖明显高于其它组别,而共培养液则对ACC-M细胞的增殖没有明显影响.结论:SD大鼠坐骨神经培养液作用于腺样囊性癌细胞,能有效促进腺样囊性癌细胞的增殖,这可能是腺样囊性癌嗜神经侵袭的基础.

  4. 正丁酸钠对涎腺腺样囊性癌细胞株ACC-2侵袭、迁移的影响及机制研究%The effect and mechanism of sodium butyrate on the invasion and migration in human salivary gland adenoid cystic carcinoma cell line ACC-2

    Institute of Scientific and Technical Information of China (English)

    王越; 吴娟娟; 刘昕; 李亦婕; 王雨; 魏丹; 宋琦; 李萍

    2016-01-01

    Objective To observe the effect of sodium butyrate on the invasion and migration of human salivary gland ade‐noid cystic carcinoma cell line ACC‐2 in vitro and to investigate the underlying mechanisms .Methods The cultured ACC‐2 cells were treated with different concentrations of sodium butyrate for 24 h ,and detected the viability rate of the cells by methyl thiazolyl tetrazolium(MTT) assay ;the drug′s influence on invasion and migration on ACC‐2 were detected by Transwell experiment ,while the protein and mRNA expression of HMGB1 and TLR4 explored by Western‐blot and RT‐PCR assay ;the relationship between TLR4 expression and HMGB1 was investigated .Results Compared with control group ,0 .625 ,1 .250 ,2 .500 ,5 .000 ,10 .000 mmol/L groups of sodium butyrate inhibited the proliferation of ACC‐2 cells(P0 .05);only 2 .500 ,5 .000 and 10 .000 mmol/L groups inhibited ACC‐2 cells migration and down‐regulated the protein and mRNA of HMGB1 and TLR4(P<0 .05) .Correlation analysis showed a positive correlation between the TLR4 protein and HMGB1 protein(r=0 .810 ,P<0 .05) .Conclusion Sodium butyrate could inhib‐it ACC‐2 cells proliferation and high concentration gropes inhibit ACC‐2 cells migration ,while reducing HMGB1 and TLR4 mRNA and protein expression ,suggesting that NaB might inhibite ACC‐2 cells migration through down‐regulated the mRNA and protein expression .%目的:探讨不同浓度正丁酸钠对涎腺腺样囊性癌细胞株ACC‐2侵袭、迁移的影响与其作用机制。方法噻唑蓝(M T T )法探索正丁酸钠作用ACC‐2细胞的最佳浓度,Transwell小室实验检测正丁酸钠对 ACC‐2细胞侵袭、迁移能力的影响, Western blot和实时荧光定量 PCR(RT‐PCR)分别检测5组浓度药物作用后ACC‐2细胞中高迁移率族蛋白1(HMGB1)、TLR4的mRNA和蛋白的表达。结果与对照组相比,0.625、1.250、2.500、5.000、10.000 mmol/L 5组浓度的正丁酸钠均能抑制ACC‐2细胞增殖(P<0.05)且呈明显浓度依赖性;5组浓度正丁酸钠对细胞侵袭能力的影响差异无统计学意义(P>0.05);2.500、5.000、10.000 mmol/L浓度正丁酸钠可以抑制ACC‐2细胞的迁移能力(P<0.05),同时降低ACC‐2细胞 HMGB1、TLR4的mRNA及蛋白表达(P<0.05);相关性分析显示TLR4蛋白表达的降低与 HMGB1的抑制呈正相关(r=0.810,P<0.05)。结论正丁酸钠能够抑制ACC‐2细胞增殖,浓度较高时可以抑制ACC‐2细胞的迁移能力,同时降低HMGB1、TLR4的mRNA与蛋白表达,提示NaB对ACC‐2迁移能力抑制可能通过下调 HMGB1、TLR4的mRNA及蛋白表达来实现。

  5. Study of garlic oil combined with cisplatin-induced apoptosis of human adenoid cystic carcinoma ACC-M cell lines%大蒜油联合顺铂诱导人腺样囊性癌细胞株ACC-M凋亡

    Institute of Scientific and Technical Information of China (English)

    樊治英; 吴发印; 周鹤峰; 朱雅文

    2014-01-01

    目的 探讨大蒜油联合顺铂对人腺样囊性癌细胞株ACC-M细胞增殖、细胞周期及凋亡的影响.方法 采用不同浓度大蒜油、顺铂、大蒜油联合顺铂分别处理人腺样囊性癌细胞株ACC-M细胞24、48、72 h后,MTT法检测肿瘤细胞体外增殖抑制情况;选取2、8、32 μg/mL的大蒜油、顺铂、大蒜油联合顺铂处理肿瘤细胞4、8h后,流式细胞术分析肿瘤细胞周期分布和凋亡率.结果 8、16、32 μg/mL大蒜油及2、4、8、16、32 μg/mL顺铂、大蒜油联合顺铂作用24、48、72 h对ACC-M细胞均有明显抑制作用,随浓度及时间增加,抑制率呈上升趋势.联合组用药肿瘤细胞抑制率明显高于单一用药组.流式细胞术结果显示,不同浓度的大蒜油、顺铂、大蒜油联合顺铂作用能使ACC-M细胞发生G2/M期阻滞,诱导细胞凋亡,随浓度增高及作用时间延长,周期分布越明显,凋亡率增高,联合组用药细胞周期阻滞和促凋亡作用明显强于单一用药组,差异有统计学意义(P<0.05).结论 不同浓度的大蒜油、顺铂、大蒜油联合顺铂均能有效抑制ACC-M细胞生长,阻滞细胞于G2/M期并诱导肿瘤细胞凋亡,大蒜油联合顺铂对ACC-M细胞生长抑制作用明显强于大蒜油、顺铂单独应用.

  6. Expression of E-cad and Ep-CAM in head and neck adenoid cystic carcinoma and its clinical significance%E-cad、Ep-CAM 在头颈部腺样囊性癌中表达的临床意义

    Institute of Scientific and Technical Information of China (English)

    李雷激; 张迪; 覃纲; 向兰; 刘跃华; 祝琳; 骆文龙

    2015-01-01

    Objective To study the expression of E-cad,Ep-CAM in head and neck ACC and clarify its role and in the malig-nant progress,invasion and metastasis of ACC.Methods The expression of E-cad and Ep-CAM in 60 cases of head and neck ACC specimens and 30 cases of normal gland tissues were detected by immunohistochemistry EnVision method.The result of immunohis-tochemistry was conducted by the Image-Pro Plus 6.0 image analysis system.Results The expression of E-cad in head and neck ACC was statistically significant lower than that in normal gland tissue(P <0.05).The expression of Ep-CAM in head and neck ACC was statistically significant higher than that in normal gland tissue(P <0.05).The decreasing expression of E-cad in head and neck ACC was closely related to the different pathological patterns,clinical stages,neurological symptom and local recurrences or distant metastases(P <0.05).The high expression of Ep-CAM in head and neck ACC was closely related to the different pathologi-cal patterns,clinical stages,neurological symptoms and local recurrences or distant metastases(P <0.05).There was a negative cor-relation about the expression between E-cad and Ep-CAM in head and neck ACC(r=-0.890,P =0.000).Conclusion E-cad may act as a inhibitor in the occurrence and development of ACC.The higher expression of Ep-CAM in head and neck ACC showed that ACC had a more poorer prognosis.%目的:研究细胞黏附分子(CAM)上皮性钙黏连蛋白(E-cad)、上皮细胞黏附分子(Ep-CAM)在头颈部腺样囊性癌(ACC)中的表达情况,探讨其在头颈部 ACC 发生、发展及侵袭转移中的作用。方法应用免疫组织化学 EnVision 法检测60例头颈部 ACC 及30例正常腺体组织中 E-cad、Ep-CAM 的表达情况,采用 Image-Pro Plus 6.0图像分析系统对免疫组织化学结果进行分析。结果E-cad 在头颈部 ACC 中的表达低于正常腺体组织(P <0.05),Ep-CAM 在头颈部 ACC 中的表达高于正常腺体组织(P <0.05);E-cad 在头颈部 ACC 组织中的相对低表达分别与 ACC 的病例分型、临床分期、有无神经症状及有无复发转移有关(P <0.05);Ep-CAM 在头颈部 ACC 组织中的高表达分别与 ACC 的病例分型、临床分期、有无神经症状及有无复发转移有关(P <0.05)。E-cad 与 Ep-CAM 在头颈部 ACC 中的表达呈负相关关系(r =-0.890,P =0.000)。结论E-cad 可能具有抑制头颈部 ACC 发生、发展的作用,Ep-CAM 在头颈部 ACC 中表达越高,提示头颈部 ACC 恶性程度越高。

  7. 人腺样囊性癌细胞热休克蛋白gp96肽复合物的纯化和鉴定%Purification of Heat Shock Protein gp96 Peptide Complex of Adenoid Cystic Carcinoma Tumor Cells

    Institute of Scientific and Technical Information of China (English)

    刘洋; 樊明文

    2012-01-01

    Objective: To purify heat shork protein(HSP)gp96 peptide complexes from human ACC-M and ACC -2 cells. Methods: gp96 tumor peptides were purified from tumor cell by ConA - Sepharose column, and DEAE ino-exchange chromatography. The purified fractions were tested by SDS-PAGE and western blot. The highly purified HSP96 peptides complex can be obtained successfully by using the affinity chromatography and DEAE ion-exchange chromatography. Results: Sharp bands with molecular weight of about 96 kD were obtained and shown to be gp96 as confirmed by western blot. 77μg and 85μg gp96 peptides complex have been extracted from1g human ACC-M and ACC-2 cells. Conclusion; The highly purified HSP96 peptides complex can be obtained successfully by using the affinity chromatography and DEAE ion-exchange chromatography.%目的:建立从人腺样囊性癌细胞系中提取gp96-肽复合物的方法.方法:培养人腺样囊性癌(ACC-M和ACC-2)细胞系,经裂解、盐析、过Con A亲和柱、透析、DEAE- Sepharose离子交换层析后得到目的蛋白,对进行蛋白质浓度、分子量及性质进行鉴定.结果:取湿重同为1g的两株细胞,纯化后得到总量分别为77 μg和85 μg的产物,电泳结果显示纯化蛋白分子量约为96KD,western blot显示产物是gp96-肽复合物.结论:采取上述方法从腺样囊性癌细胞中得到了较高纯度的gp96-肽复合物.

  8. Expression of S100 Protein and GFAP and Their Correlation with Perineural Invasion in Adenoid Cystic Carcmoma%S100蛋白和GFAP在腺样囊性癌中的表达及与嗜神经侵袭的关系

    Institute of Scientific and Technical Information of China (English)

    王永功; 阚云珍

    2008-01-01

    目的 观察S100蛋白和GFAP在腺样囊性癌中的表达情况,探讨其与腺样囊性癌嗜神经侵袭间的关系.方法采用免疫组化方法对45例腺样囊性癌以及正常腮腺组织中的S100蛋白和GFAP进行检测.结果 45例腺样囊性癌中,有34例出现癌细胞包绕或侵袭神经现象,11例无此类现象,S100蛋白和GFAP在嗜神经现象组的阳性率分别为100%(34/34)、94.14%(32/34),在非嗜神经现象组阳性率为90.91%(10/11)、45.45%(5/11).两组间S100蛋白阳性率无明显差异(P>0.05),GFAP阳性率比较差异明显,P<0.01.结论 S100蛋白和GFAP在腺样囊性癌中均过表达,但GFAP在两组间差异明显,可能与腺样囊性癌嗜神经侵袭的关系密切.

  9. Syndrome de Meckel Gruber: à propos d’un cas rare

    Science.gov (United States)

    Itchimouh, Sanaa; Khabtou, Karima; Mahdaoui, Sakher; Boufettal, Houssine; Samouh, Naima

    2016-01-01

    Le syndrome de Meckel Gruber est un syndrome poly malformatif rare, de transmission autosomique récessive, défini par d'encéphalocèle occipital, polydactylie et dysplasie kystique rénale. L'échographie constitue, à l'heure actuelle, le meilleur moyen de dépistage anténatal de cette poly malformation létale et sa confirmation se fait par l'étude du caryotype. Nous rapportons un cas de syndrome de Meckel découvert par échographie. La grossesse a été interrompue à 25 semaines d'aménorrhée. PMID:28154732

  10. CANCER BRONCHO-PULMONAIRE ET thérapeutique

    OpenAIRE

    Chater, Asma

    2014-01-01

    Le cancer du poumon est une maladie caractérisée par une croissance incontrôlée des cellules dans les tissus du poumon. Si elle n'est pas traitée, cette croissance peut se propager au-delà du poumon dans un processus appelé métastase dans les tissus voisins et, éventuellement, dans d'autres parties du corps. La plupart des cancers qui commencent dans les poumons, connue sous le nom cancers du poumon primaires, sont des carcinomes qui dérivent de cellules épithéliales. Les principaux types de ...

  11. Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells

    OpenAIRE

    TANG, Li; Yi, Xue-Mei; Chen, Jia; Chen, Fu-Juan; Lou, Wei; Gao, Yun-Lu; Zhou, Jing; Su, Li-Na; Xu, Xin; Lu, Jia-Qing; Ma, Jun; Yu, Ning; Ding, Yang-Feng

    2016-01-01

    Melanoma is the most aggressive type of skin cancer, exhibiting extensive local invasion and early distant metastasis. Aberrant expression of ubiquitin-protein ligase E3C (UBE3C) plays a key role in tumor development and progression. In the present study, we analyzed UBE3C expression in samples of cancerous and normal skin tissue. Levels of UBE3C expression were much higher in primary and metastatic melanoma tissues than in normal skin, cutaneous squamous cell carcinoma or basal cell carcinom...

  12. Association synchrone d'un cancer du sein bilatéral et d'une tumeur stromale gastro-intestinale: à propos d'un rare cas

    OpenAIRE

    Afif, Mohammed; Ouziane, Imane; Kouhen, Fadila; Khalil, Jihane; Elomrani, Fedwa; Elkacemi, Hanan; Kebdani, Tayeb; Errihani, Hassan; Benjaafar, Noureddine

    2015-01-01

    Les tumeurs stromales gastro-intestinales sont les tumeurs mésenchymateuses les plus fréquentes, pourtant, leur association avec les tumeurs du sein sont rares, seulement quelques cas cliniques sont rapportés dans la littérature. Nous rapportons l'observation d'une jeune femme de 41 ans, suivie à l'institut national d'oncologie de Rabat, pour un carcinome canalaire du sein, bilatéral, chez qui le bilan d'extension a objectivé une tumeur stromale de type gastro-intestinale aux dépens de l'esto...

  13. Clear-cell carcinoma of the lung metastatic to the hamate: a case report.

    Science.gov (United States)

    Nissenbaum, M; Kutz, J E; Lister, G D

    1978-01-01

    Metastatic lesions of the hand are uncommon. A report of a solitary metastasis to the hamate seems not to have appeared previously in the literature. A 46-year-old factory worker presented a rare tumor, clear-cell carcinom of the lung, metastasizing to an unusual location, the hamate. The symptoms simulated sympathetic dystrophy and diagnosis was delayed because of the late appearance of radiographic changes over 6 months after symptoms first appeared. Early bone scanning in patients with chronic pain may provide useful information prior to the appearance of X-ray changes.

  14. HYPERTROPHICALUM ADENOIDIS IN RE-LATIUM CUM SECRETUM OTTITIS IN MEDIAM

    Directory of Open Access Journals (Sweden)

    Lidija DUBROVSKA-MILETIC

    1999-11-01

    Full Text Available In this study we presented the treatment of 20 children with secretory otitis media (SOM. The treatment was surgical and it considened-ventilaton tube insertion and adenoidectomy in case of enlarged adenoid. In this clinical investigation was enroll 15 boys and 5 girls in age 5 to 10 were divided in two main groups:1. 9 children without enlarged adenoid2. 11 children with confirmed enlarged adenoidClinical material was analyzed according to hearing level, middle ear condition estimated by pure toneaudiiometry and tympanometry before and after the treatment. The result showed that adenoidectomy in combination with ventilation tube insertion facilitate secretory otitis media. That’s enable timely improving of hearing function us a important on development of speech, social, emotional and academic development in the early childhood.

  15. [Children severe OSAHS with pectus excavatum: a case report].

    Science.gov (United States)

    Ma, Wei; Wang, Jinfeng; Xie, Yuping

    2016-03-01

    The primary etiopathology of pediatric OSAHS includes tonsil or adenoid hypertrophy. Severe OSAHS contributes to or aggravates thoracic deformity, which is rarely reported. In the current report, This children sleep snoring more than 4 years, increasing with thoracic severe depression during sleep 2 days. Clinical examination indicated tonsil and adenoid hypertrophy, and polysomnography revealed OSAHS . The symptoms of OSAHS and severe inhalation-related sternum depression disappeared rapidly after tonsillectomy. Our findings indicated that OSAHS were the major causes underlying funnel chest in children. The rarity of the incidence may result in missed diagnosis or misdiagnosis. Polysomnography was recommended for the child diagnosed with funnel chest accompanied by upper airway stenosis.

  16. Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)

    DEFF Research Database (Denmark)

    Bjørndal, Kristine; Krogdahl, Annelise; Therkildsen, Marianne Hamilton;

    2011-01-01

    years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.......2%). The revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent...

  17. Neuralgia associated with transcutaneous electrical nerve stimulation therapy in a patient initially diagnosed with temporomandibular disorder.

    Science.gov (United States)

    Omolehinwa, Temitope T; Musbah, Thamer; Desai, Bhavik; O'Malley, Bert W; Stoopler, Eric T

    2015-03-01

    Head and neck neoplasms may be difficult to detect because of wide-ranging symptoms and the presence of overlapping anatomic structures in the region. This case report describes a patient with chronic otalgia and temporomandibular disorder, who developed sudden-onset neuralgia while receiving transcutaneous electrical nerve stimulation (TENS) therapy. Further diagnostic evaluation revealed a skull base tumor consistent with adenoid cystic carcinoma. To our knowledge, this is the first report of TENS-associated neuralgia leading to a diagnosis of primary intracranial adenoid cystic carcinoma.

  18. Ulcere de Marjolin: complication redoutable des sequelles de brûlures

    Science.gov (United States)

    Ouahbi, S.; Droussi, H.; Boukind, S.; Dlimi, M.; Elatiqi, O.K.; Elamrani, M.D.; Benchamkha, Y.; Ettalbi, S.

    2013-01-01

    Summary L’ulcère de Marjolin désigne la transformation maligne d’une cicatrice de brûlure ou de toute autre plaie ou ulcération chronique. Le type histologique prédominant reste le carcinome épidermoïde, et il est caractérisé par son agressivité locale, des métastases plus fréquentes, un risque de récurrence et une mortalité plus importante que les carcinomes épidermoïdes classiques. Notre travail est une étude rétrospective portant sur 21 cas d’ulcère de Marjolin, colligés au service de chirurgie plastique du CHU Mohammed VI de Marrakech, avec pour but de relever les aspects épidémiologiques, thérapeutiques et évolutifs de cette pathologie. L’amélioration du pronostic nécessite non seulement un diagnostic et un traitement précoce, mais surtout une attitude préventive qui consiste en des greffes cutanées précoces et des soins réguliers de toute cicatrice de brûlure. PMID:24799850

  19. 碱性成纤维细胞生长因子对人涎腺腺样囊性癌ACC-2细胞株增殖及MEK/ERK、MKP-1通路的影响%Effects of basic fibroblast growth factor on the proliferation of human salivary adenoid cystic carcinoma ACC-2 cell line and the signaling pathway of MEK/ERK and MKP-1

    Institute of Scientific and Technical Information of China (English)

    丁蕾; 朱声荣; 汤国雄; 向国林

    2007-01-01

    目的:观察碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)对人涎腺腺样囊性癌ACC-2细胞株增殖及MEK1/2、ERK1/2及MKP-1表达的影响.方法:培养人涎腺腺样囊性癌细胞株(ACC-2),MTT比色法测定不同浓度bFGF对细胞增殖的影响;免疫沉淀法纯化蛋白并ERK试剂盒测定ERK活性;免疫印迹法测定p-MEK1/2、p-ERK1/2及MKP-1表达.结果:MTT实验显示bFGF明显增强ACC-2细胞增殖,免疫沉淀法显示bFGF上调ERK活性,免疫印迹法显示bFGF明显增强p-MEK1/2、p-ERK1/2表达及抑制MKP-1表达.结论:bFGF可促进人涎腺腺样囊性癌ACC-2细胞株增殖,其途径与上调ERK活性、激活MEK/ERK通路、抑制MKP-1表达有关.

  20. The diagnostic difficulties in tracheal neoplasms; Trudnosci diagnostyczne w nowotworach tchawicy

    Energy Technology Data Exchange (ETDEWEB)

    Bartnik, W.; Szewczyk, M.; Lomikowska, E.; Meler, M.; Rosolowska, J. [Wojewodzki Szpital Zespolony, Kalisz (Poland)

    1994-12-31

    Since 1990-1992 in the Dept. of ENT Kalisz 5 patients with tracheal neoplasms were treated. On the base of this cases the diagnostic difficulties has been presented. A rare case of tracheal carcinoma adenoides treated by telecobaltotherapy was described. 6 years survival rate was observed. (author)

  1. Bacterial Interference in Nasopharyngeal Bacterial Flora of Otitis-prone and Non-otitis-prone Children

    NARCIS (Netherlands)

    J.M. Bernstein; S. Sagahtaheri-ALtaie; D.M. Dryja; J. Wactawski-Wende

    1994-01-01

    textabstractThe quantitative bacteriology of the adenoid was studied in 34 otitis-prone and 25 non-otitis prone children. Viridans streptococci appeared to be the predominant normal flora in children who are non-otitis prone. There was a significant decrease in viridans streptococci in the otitis-pr

  2. Viral Vectors for Use in the Development of Biodefense Vaccines

    Science.gov (United States)

    2005-06-17

    in 1954 when scientists were trying to establish cells lines derived from tonsil and adenoidal tissues and has recently been utilized extensively as a...Ferguson, D.M. Stone , J. Meredith, J.W. Almond, P.D. Minor, Live-attenuated strains of improved genetic stability, Dev. Biol. (Basel) 105 (2001) 179–187

  3. Medical Surveillance Monthly Report (MSMR). Volume 8, Number 2, March/April 2002

    Science.gov (United States)

    2002-04-01

    Fracture of ankle 38 4 Chronic disease of tonsils and adenoids 31 8 Complications affecting specified body systems 35 4 Table 3. Most frequent...51) 420 (66) Other breast disorders 16,649 (58) 8,881 (59) 467 (64) Kidney stones 12,327 (63

  4. Nocturnal apnea in Chiari type I malformation

    NARCIS (Netherlands)

    Aarts, L.A.; Willemsen, M.A.A.P.; Vandenbussche, N.L.; Gent, R. van

    2011-01-01

    A 4-year-old girl presented with sleep-disordered breathing. Her parents described breathing pauses of up to 20 s and progressive tiredness during the day. Obstructive apneas from an enlarged adenoid were thought to be the most probable cause. However, an adenotomy did not resolve the problem. Polys

  5. [Adenotonsillectomy in children only under exceptional circumstances

    NARCIS (Netherlands)

    Bosch, W.J.H.M. van den; Lisdonk, E.H. van de

    2005-01-01

    More and more evidence is becoming available that throws doubt on the value of adenotonsillectomy in children with frequent throat infections or hypertrophic tonsils and adenoids. Tonsillectomy and adenoidectomy have a limited range of indications. Objective symptoms such as the size of the tonsils

  6. Examination of the reticular epithelium of the bovine pharyngeal tonsil

    Science.gov (United States)

    The nasopharyngeal tonsil (adenoid), located at the posterior of the nasopharynx is ideally positioned to sample antigens entering through the nasal cavity or oral cavity. Entering antigens will first contact tonsilar epithelium. To better understand the cellular composition of this important epithe...

  7. My Child Has Tonsillitis. Will He Need to Have His Tonsils Removed?

    Science.gov (United States)

    ... breathing difficult (this may or may not include sleep apnea). Tonsils that are so swollen that your child has a problem swallowing. An enlarged adenoid that makes breathing uncomfortable, severely alters speech and possibly affects normal growth of the face. In this case, surgery to ...

  8. Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck

    Science.gov (United States)

    2017-04-03

    Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage 0 Hypopharyngeal Cancer; Stage 0 Laryngeal Cancer; Stage 0 Lip and Oral Cavity Cancer; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVB

  9. Drug induced sleep endoscopy in the decision-making process of children with obstructive sleep apnea.

    Science.gov (United States)

    Galluzzi, Francesca; Pignataro, Lorenzo; Gaini, Renato Maria; Garavello, Werner

    2015-03-01

    Tonsillectomy and adenoidectomy (T&A) is currently recommended in children with Obstructive Sleep Apnea (OSA). However, the condition persists after surgery in about one third of cases. It has been suggested that Drug Induced Sleep Endoscopy (DISE) may be of help for planning a more targeted and effective surgical treatment but evidence is yet weak. The aim of this review is to draw recommendation on the use of DISE in children with OSA. More specifically, we aimed at determine the proportion of cases whose treatment may be influenced by DISE findings. A comprehensive search of articles published from February 1983 to January 2014 listed in the PubMed/MEDLINE databases was performed. The search terms used were: "endoscopy" or "nasoendoscopy" or "DISE" and "obstructive sleep apnea" and "children" or "child" or "pediatric." The main outcome was the rate of naive children with hypertrophic tonsils and/or adenoids. The assumptions are that clinical diagnosis of hypertrophic tonsils and/or adenoids is reliable and does not require DISE, and that exclusive T&A may solve OSA in the vast majority of cases even in the presence of other concomitant sites of obstruction. Five studies were ultimately selected and all were case series. The median (range) number of studied children was 39 (15-82). Mean age varied from 3.2 to 7.8 years. The combined estimate rate of OSA consequent to hypertrophic tonsils and/or adenoids was 71% (95%CI: 64-77%). In children with Down Syndrome, the combined estimated rate of hypertrophic tonsils and/or adenoids was 62% (95%CI: 44-79%). Our findings show that DISE may be of benefit in a minority of children with OSA since up to two thirds of naive cases presents with hypertrophic tonsils and/or adenoids. Its use should be limited to those whose clinical evaluation is unremarkable or when OSA persists after T&A.

  10. Inflammatory cytokine detection in adenotonsill and peripheral blood mononuclear cells- culture in adenotonsillectomy patients: a comparative study

    Directory of Open Access Journals (Sweden)

    Farhadi M

    2013-04-01

    Full Text Available Background: Tonsils and adenoid hypertrophy is a major respiratory symptom in children which is partly due to recruitment of inflammatory cells in upper airway lymph nodes as a result of the effects of synthesis and release of different inflammatory cytokines. It seems that infections play role in concert with these cytokines leading to tonsilar hypertrophy and other pathologic consequences. It is proposed that cellular infiltrate of tonsils and adenoids may secrete different quantities of these cytokines compared with peripheral blood mononuclear cells (PBMC cultures.Methods: Among patients who were admitted for adenotonsillectomy to the ENT ward, 37 patients, under 1-12 years old patients with fulfill criteria selected to include the study. Excised adenoid and tonsils cultured and inflammatory cytokines Interferon-γ (INF-γ, Interlukine-1 (IL-1, IL-6, IL-8 and tumor necrosis factor-α (TNF-α measured in cellular culture supernatant. The same cytokines measured in PBMC cultures.Results: The data shows that there is a significant difference between IFN-γ and IL-8 amounts in adenoid tissue culture supernatant and PBMC culture of our patients. Furth-ermore, the amounts of IFN-γ, IL-1 and IL-8 showed considerable difference between tonsilar tissue culture supernatant and PBMC culture of these patients. Although there is a significant correlation between IL-6 amounts in tissue culture supernatant and PBMC culture (P=0.02, the respective data for TNF is only almost significant.Conclusion: Inflammatory cytokines may have significant role in the early provoke of inflammation occurred in hypertrophied tonsils and adenoid. The majority of these cyt-okines increase the expression of adhesion molecules on epithelial cells and influence the recruitment of leucocytes and inflamed tonsils. On the other hand lack of sufficient cytokine release may lead to persistent infections and may cause chronic inflammation and hypertrophied tissue.

  11. Effects of Autogenic Drainage on Sputum Recovery and Pulmonary Function in People with Cystic Fibrosis: A Systematic Review.

    Science.gov (United States)

    Morgan, Kimbly; Osterling, Kristin; Gilbert, Robert; Dechman, Gail

    2015-01-01

    Objet: Déterminer les effets de l'utilisation à court et à long terme du drainage autogène (DA) sur la fonction pulmonaire et la récupération de crachat chez les personnes qui ont la fibrose kystique (FK). Méthodes: Les auteurs ont procédé à un examen systématique d'essais cliniques randomisés et quasi-randomisés où les participants étaient des personnes vivant avec la FK qui utilisent le DA comme seule méthode de dégagement des voies aériennes (DVA) Résultats: Les recherches effectuées dans quatre bases de données et des sources secondaires au moyen de cinq termes clés ont produit 735 articles dont 58 contenaient les expressions « drainage autogène » et « fibrose kystique ». On a inclus finalement quatre études dont deux à long terme. Toutes les études ont mesuré le volume expiratoire maximum seconde (VEMS1) et n'ont constaté aucun changement. Des études de longue durée n'avaient pas le pouvoir nécessaire pour détecter tout changement du VEMS1, mais des études de courte durée ont constaté une production cliniquement significative de crachat (≥4 grammes). Conclusion: Il a été démontré, dans un nombre limité d'enquêtes, que le DA produit des volumes cliniquement significatifs de crachat. L'effet du DA sur le fonctionnement de l'appareil pulmonaire demeure incertain et des questions ont surgi au sujet de la pertinence du VEMS1 comme mesure valide du dégagement des voies aériennes à partir des régions pulmonaires périphériques. Il faudrait envisager d'utiliser le VEMS1 comme mesure première de l'effet du DA.

  12. 鼻内镜下经口径路腺样体切除术62例临床分析%Adenoidectomy through mouse under endoscopy:with a report 62 cases

    Institute of Scientific and Technical Information of China (English)

    姜梁; 胡晓艳

    2014-01-01

    目的:探讨经口径路鼻内镜下腺样体切除术的治疗效果和优点。方法:经口径路在鼻内镜下行腺样体切除术62例,治疗由腺样体肥大引起的咽鼓管功能障碍、小儿鼾症和鼻腔阻塞。结果:术后无腺样体组织残留,鼻咽部组织无损伤和出血等并发症,患者术前症状明显改善或消失。结论:采取该手术方式,能彻底清除病变组织,增加手术的准确性和安全性,疗效好且并发症少。%Objective:To probe into the curative effects,advantages of utilizing nasal endoscopy in adenoidectomy.Meth-od:62 cases with sleep respiratory disorder,nose block,hearing loss caused by adenoid hypertrophy were operated by ad-enoidectomy through mouse under endoscopy.Result:The adenoid gland was removed completely and the anatomic con-figuration of nasopharynx was well viewed after operation.All cases were recovered without complications.Conclusion:Adenoidectomy through mouse under endoscopy provides a direct and clear viewthat allows the surgeon to re -move ade-noid tissue accurately and effectively with few complications. Objective:To probe into the curative effects,advantages of utilizing nasal endoscopy in adenoidectomy.Meth-od:62 cases with sleep respiratory disorder,nose block,hearing loss caused by adenoid hypertrophy were operated by ad-enoidectomy through mouse under endoscopy.Result:The adenoid gland was removed completely and the anatomic con-figuration of nasopharynx was well viewed after operation.All cases were recovered without complications.Conclusion:Adenoidectomy through mouse under endoscopy provides a direct and clear viewthat allows the surgeon to re -move ade-noid tissue accurately and effectively with few complications.

  13. Métastases gastro-intestinales du cancer du sein: à propos de 2 cas

    Science.gov (United States)

    Loubna, Mezouar; Mohamed, El Hfid; Tijani, El Harroudi; Fouzia, Ghadouani; Hanane, Haj Kacem; Zouhour, Bourhaleb; Asmae, Ouabdelmoumen

    2013-01-01

    Le cancer du sein est le cancer le plus fréquent chez la femme, notamment au Maroc, avec un taux de mortalité élevé. Les métastases gastro-intestinales d'un carcinome canalaire du sein sont rares. Leur diagnostic est difficile du fait de la nature non spécifique des symptômes. Nous rapportons deux observations originales de métastases gastroduodénales d'un cancer canalaire infiltrant du sein. Les métastases gastro-intestinales du cancer du sein sont très rares; la présence de symptômes gastro-intestinaux chez une malade ayant un antécédent de cancer du sein doit faire suspecter une atteinte métastatique gastro-intestinale. PMID:24198876

  14. Papillome inversé: étude rétrospective à propos de 22 cas

    OpenAIRE

    2014-01-01

    Le papillome inversé est une tumeur bénigne naso-sinusienne rare, marquée par une forte agressivité locale, un taux élevé de récidive après chirurgie et un risque imprévisible d'association à un carcinome épidermoïde. Il s'agit d'une étude rétrospective de 22 cas de papillome inversé, colligés entre janvier 2000 et décembre 2012 au service d'oto-rhino-laryngologie et chirurgie cervico-faciale de l'hôpital militaire Avicenne de Marrakech. L'objectif de ce travail est d’étudier le profil épidém...

  15. Carcinoïde primitif du rein métastasant après 12 ans

    Science.gov (United States)

    Bacha, Dhouha; Lahmar, Ahlem; Gharbi, Lassad; Slama, Sana Ben; Bouraoui, Saadia; Chatti, Samia; Regaya, Sabeh Mzabi

    2016-01-01

    Les carcinoïdes primitifs du rein sont rares avec une centaine de cas rapportés dans la littérature. Sur le plan histologique, il s'agit d'une tumeur bien différenciée dont la morphologie rejoint souvent celle des carcinoïdes dans les autres localisations. Nous rapportons un cas de carcinoïde primitif du rein survenant chez un homme de 41 ans, découvert à la suite de métastases hépatiques. La tumeur était particulière par son architecture tubulo-papillaire, suggérant à tort le diagnostic de carcinome papillaire du rein. Ce diagnostic a été redressé 12 ans après, à la suite de l'apparition d'autres métastases hépatiques, osseuses et pulmonaires. PMID:27217899

  16. Genotype-phenotype correlation in cystic fibrosis patients compound heterozygous for the A455E mutation.

    Science.gov (United States)

    De Braekeleer, M; Allard, C; Leblanc, J P; Simard, F; Aubin, G

    1997-12-01

    Cystic fibrosis (CF) has a high incidence in the French-Canadian population of Saguenay Lac-Saint-Jean (Quebec). The A455E mutation accounts for 8.3% of the CF chromosomes. This mutation was shown to be associated with a milder lung disease in the Dutch population. Twenty two CF patients distributed in 17 families and compound heterozygotes for the A455E mutation have been followed at the Clinique de Fibrose Kystique de Chicoutimi. Fourteen patients also carried the delta F508 mutation while the remaining eight patients had the 621 + 1G-->T mutation. Each patient was matched by sex and age to a patient homozygous for the delta F508 mutation. The pairs were analyzed for several clinical and laboratory variables. The A455E compound heterozygotes were diagnosed at a later age (P = 0.003) and had chloride concentrations at the sweat test lower than those homozygous for the delta F508 mutation (P = 0.007). More patients were pancreatic sufficient (P = 0.004). They had a higher Shwachman score (P = 0.001) and better pulmonary function tests (P < 0.02). CF patients compound heterozygous for the A455E mutation have a milder pancreatic and lung disease than the delta F508 homozygotes. Therefore, the A455E should be associated with a better prognosis.

  17. Neurocysticercose révélée par une épilepsie réfractaire: à propos d'une observation

    Science.gov (United States)

    Bugeme, Marcellin; Mukuku, Olivier

    2015-01-01

    Nous rapportons une observation de neurocysticercose parenchymateuse chez un homme de 38 ans, consommant régulièrement la viande de porc, qui a présenté une épilepsie réfractaire. Le diagnostic de NCC était basé sur la présence de lésions kystiques montrant le scolex sur les images du scanner cérébrale, la présence de signes cliniques évocateurs de NCC (épilepsie faite des crises convulsives focales évoluant vers des crises bilatérales), la réponse clinique au traitement à l'albendazole et le fait que notre patient vit dans une zone reconnue endémique à la cysticercose. Après un traitement fait d'albendazole et de prednisolone, l’évolution est marquée par la disparition complète des crises épileptiques. PMID:26090052

  18. 气管腺样囊性癌的研究进展

    Institute of Scientific and Technical Information of China (English)

    郑林峰; 倪型灏

    2009-01-01

    @@ 气管原发的肿瘤稀少,占所以呼吸道肿瘤的1%[1],且恶性肿瘤比良性肿瘤多见,占60~83%[2].气管腺样囊性癌(tracheal adenoid cystic carcinoma,TACC)属原发于气管的上皮性癌,在气管癌中约占30%[3].腺样囊性癌(adenoid cystic carcinoma,ACC)曾称"圆柱瘤"和"囊性腺样癌",最早由Billor根据组织病理形态表现为上皮岛内间质相互编织呈圆柱形状而命名的.

  19. Anticoccidial action of monensin in turkey poults.

    Science.gov (United States)

    McDougald, L R

    1976-11-01

    Monensin was effective within the range 60-100 p.p.m. in control of coccidiosis in turkey poults in a series of laboratory experiments. Under conditions of heavy infections with Eimeria meleagrimitis and E. adenoides, 100 p.p.m. of monesin was significantly more effective than 60 p.p.m. in protecting weight gains. When light or moderate infections with E. meleagrimitis, E. adenoides and E. gallopavonis were used, there were no significant differences among monesin-medicated treatments. In all instances the monensin-medicated treatments gained significantly more weight than noninfected, nonmedicated controls, when measured at 7 days post-inoculation. Similarly, oocyst, passage was reduced, feed conversion was protected and mortality was controlled in monensin-treated poults.

  20. 乳腺基底细胞样实体型腺样囊性癌1例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    郦秀芳; 吕艳婷; 魏建丽; 张海勇; 胡孟钧

    2011-01-01

    @@ 乳腺腺样囊性癌(adenoid cystic carcinoma, ACC)较罕见,在乳腺恶性肿瘤中所占比例<1%[1],具有低度浸润潜能,预后好.基底细胞样实体型腺样囊性癌(solid variant of adenoid cystic carcinoma with basaloid fertures, sb,ACC)是其中一种特殊亚型,文献报道极少,现将笔者近期诊治的1例患者的临床病理资料作一回顾性分析,报道如下.

  1. Coblation adenoidectomy our experience

    Directory of Open Access Journals (Sweden)

    Balasubramanian Thiagarajan

    2014-03-01

    Full Text Available Aim of our study is to compare the efficacy and safety of coblation adenoidectomy versus conventional cold steel adenoidectomy. The study design included 40 children between age groups 4 – 8. Twenty of these children underwent coblation adenoidectomy while the other group of 20 underwent conventional cold steel adenoidectomy. The parameters taken into consideration for comparison included Post operative pain, operating time, intraoperative bleeding and presence of residual adenoid tissue 6 weeks after surgery. In this study the coblation group demonstrated less post operative pain, less intraoperative bleeding and more complete removal of adenoid tissue. Operative time was found to be significantly higher in coblation group when compared to conventional cold steel adenoidectomy group.

  2. Brooke-Spiegler syndrome.

    Science.gov (United States)

    Szepietowski, J C; Wasik, F; Szybejko-Machaj, G; Bieniek, A; Schwartz, R A

    2001-07-01

    The Brooke-Spiegler syndrome is an autosomal dominant one characterized by cylindromas, trichoepitheliomas and occasionally spiradenomas. Within a given family, some members may have cylindromas whereas others may have trichoepitheliomas or both. We describe the coexistence of trichoepithelioma papulosum multiplex (also known as epithelioma adenoides cysticum of Brooke) and cylindromas in a 30-year-old man, and discuss the relationship between these two autosomal dominant syndromes.

  3. An nasopharynx X-ray lateral projection analysis of 105 children snoring disease%小儿鼾症鼻咽部侧位片105例X线分析

    Institute of Scientific and Technical Information of China (English)

    张志宏; 胡书君

    2011-01-01

    Objective:To study whether the nasopharynx X-ray lateral projection could be a easy and practical means to judge the size of adenoid in the children snoring disease. Methods:105 patients with children snoring disease were adopted to survey the size of adenoid through nasopharynx X-ray lareral projection in several sorts of ways, including A/N ratio.Results : After measuring all the 105 patient's adenoid size. it was got that A/N≤O. 6 in 38 cases ( 38/105) . A/NO. 61~0. 7in 59 cases (59/105) . and A/N≥O. 71 in 8 cases ( 8/105). Conclusion: Nasopharynx X-ray lateral projection is an effective and convenient approach to measure the size of adenoid and, it can be chosen as the routine method.%目的:通过对105例小儿鼾症鼻咽部侧位片的X线观察,探讨简便及适合基层医院的判断腺样体大小的检查方法.方法:105例小儿鼾症均照鼻咽部侧位片,采用A/N法测量及平行曲线法测量腺样体.结果:38例A/N≤0.6,59例A/N0.61~0.7,8例A/N≥0.71.结论:鼻咽部侧位片是了解腺样体大小的简便廉价有效的方法,可常规作为首选.

  4. [Nasal respiratory stenosis and maxillary hypoplasia. Changes after orthodontic treatment with rapid palatal expansion].

    Science.gov (United States)

    Piccini, A; Giorgetti, R; Fiorelli, G

    1989-01-01

    The relationship between hypoplasia of the upper maxillary bone and nasal respiratory insufficiency in a group of twenty infants with malocclusion being treated by rapid maxillary expansion (RME) were studied. Prior to treatment all patients presented endognatia with discrepancies of from -4 to -7 mm in the transverse basal skeleton. These were often associated with adenoid hypertrophy (70% of the cases), increased total nasal resistance (70%), oral respiration (80%) and middle ear diseases (30%). RME led to resolution of occlusion alterations in all cases and often also brought about a regression in adenoid hypertrophy (57% of the cases), normalization of the total nasal resistance (70%) and respiration (80%). These effects were achieved alone without association with any other form of medical or surgical E.N.T. treatment. The functional results confirmed by the radiological and clinical findings indicate an increase in the diameters of the nasal fossa and in the distance between the canines, between premolars and between molars as well as reduction in adenoid vegetation and in the diffuse hypertrophic tissues lining the naso-pharyngeal space. Nonetheless, hypoplasia of the upper maxillary bone and nasal respiratory insufficiency remain strictly linked and are bound to a variable, and at times uncertain, cause-effect relationship. Is nasal stenosis the moving force of maxillary-mandibular dysmorphism and gnatological dysfunction or does it result from an overall genetic conditioning of facial skeleton development? During their vast experience in adenoid and metadenoid pathologies in infancy the authors have, at times, observed significant maxillo-facial dysmorphisms. They have likewise found that "facies adenoidea" were not always associated with hypertrophy of the pharyngeal tonsil.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Medical Surveillance Monthly Report (MSMR). Volume 10, Number 2, April 2004

    Science.gov (United States)

    2004-04-01

    Chronic disease of tonsils and adenoids 25 5.4 Fracture of tibia and fibula 48 3.9 Table 3. Most frequent diagnoses during hospitalization, by major...pain 18,397 (55) 12,521 (56) 692 (61) Menstrual disorders 18,362 (56) 13,209 (55) 546 (69) Kidney stones 17,116 (59) 6,679 (63) 1,952 (38) Other

  6. Medical Surveillance Monthly Report (MSMR). Volume 7, Number 4, April 2001

    Science.gov (United States)

    2001-04-01

    Peritonsillar abscess 38 8.4 Complications due to certain procedures 53 5.8 Chronic disease of tonsils and adenoids 38 8.4 Sprains and strains of knee and leg...16,091 (59) 11,635 (56) 431 (71) Kidney stones 12,352 (66) 5,176 (67) 1,260 (42) Nephritis and nephrosis 3,598 (82) 1,263 (90) 446 (69) Benign prostatic

  7. 儿童分泌性中耳炎腺样体切除术后听力变化的临床分析%Clinical analysis on hearing changes after adenoidectomy in children with secretary otitis media

    Institute of Scientific and Technical Information of China (English)

    刘强; 佘万东; 戴艳红; 刘收厚; 李佩忠

    2012-01-01

    目的 分析手术切除儿童肥大腺样体后对分泌性中耳炎致听力下降疗效的影响.方法 对本院住院的腺样体肥大并发分泌性中耳炎的30例(49耳)患儿经鼻内镜行腺样体切除术,回顾性分析对患儿听力的治疗效果.结果 在0.25~8kHz的气导阈值,术后与手术前有显著性差异(P<0.05),术后各频率骨导阈值与手术前无显著性差异(t=1.022,P>0.05).结论 对于伴有腺样体肥大的分泌性中耳炎患儿,手术切除其肥大的腺样体可明显改善患儿的听力.%Objective To analyze the effectiveness of surgical removal of hypertrophic adenoids on hearing loss caused by secretory otitis media in children. Method 30 children in hospital with hypertrophic adenoids accompanied with secretary otitis media (49 ears) were perfomed with adenoidectomy via nasal endoscopy, and with retrospective analysis on the treatment effect of children with hearing. Results Air conduction thresholds were significantly imporved In the 0.25 - 8kHz (P0.05 ) . Conclusion In patients with secretory otitis media caused by adenoid hypertrophy, surgical excision of hypertrophic adenoids can significantly improve the children's hearing.

  8. [Nasal obstruction and mouth breathing: the ENT's point of view].

    Science.gov (United States)

    Leboulanger, Nicolas

    2013-06-01

    Obstructive diseases of children's upper airways are frequent, mostly caused by tonsils and adenoids hypertrophy. A nasal septum deviation or a lower turbinate hypertrophy may also cause a significant obstruction. Tonsillectomy and adenoidectomy must be performed in case of clinical obstruction, sometimes documented by a sleep study. A tonsils' hypertrophy without significant obstruction and clinical symptoms is not an indication of adenotonsillectomy, even in case of snoring or if an orthodontic treatment is planned.

  9. Sclerosing polycystic adenosis of the parotid gland

    Directory of Open Access Journals (Sweden)

    Hugo Lara-Sánchez

    2015-10-01

    Conclusion: The SPA is similar to the fibrocystic changes, sclerosing adenosis and adenoid tumors of the mammary gland. The main location of the SPA is the parotid gland and it is considered a disease due to a pseudotumoral inflammatory reaction with a possible association with the Epstein–Barr virus. There is evidence that monoclonal cell populations exist. The treatment consists in excision of the tumor with a superficial parotidectomy, which has demonstrated high cure rates.

  10. Submaxilectomía: causas y complicaciones. Revisión de 160 casos

    Directory of Open Access Journals (Sweden)

    Daniel García Molina

    2014-04-01

    Conclusiones: En nuestro centro la causa más frecuente de submaxilectomía la constituyen la sialoadenitis crónica y la sialolitiasis. Las neoplasias más frecuentes son el adenoma pleomorfo y el carcinoma adenoide quístico, en consonancia con diferentes estudios de otros países. Los tumores benignos son más frecuentes, en contraste con otros estudios previos.

  11. Trans-oral endoscopic partial adenoidectomy does not worsen the speech after cleft palate repair

    Directory of Open Access Journals (Sweden)

    Mosaad Abdel-Aziz

    Full Text Available ABSTRACT INTRODUCTION: Adenoid hypertrophy may play a role in velopharyngeal closure especially in patients with palatal abnormality; adenoidectomy may lead to velopharyngeal insufficiency and hyper nasal speech. Patients with cleft palate even after repair should not undergo adenoidectomy unless absolutely needed, and in such situations, conservative or partial adenoidectomy is performed to avoid the occurrence of velopharyngeal insufficiency. Trans-oral endoscopic adenoidectomy enables the surgeon to inspect the velopharyngeal valve during the procedure. OBJECTIVE: The aim of this study was to assess the effect of transoral endoscopic partial adenoidectomy on the speech of children with repaired cleft palate. METHODS: Twenty children with repaired cleft palate underwent transoral endoscopic partial adenoidectomy to relieve their airway obstruction. The procedure was completely visualized with the use of a 70° 4 mm nasal endoscope; the upper part of the adenoid was removed using adenoid curette and St. Claire Thompson forceps, while the lower part was retained to maintain the velopharyngeal competence. Preoperative and postoperative evaluation of speech was performed, subjectively by auditory perceptual assessment, and objectively by nasometric assessment. RESULTS: Speech was not adversely affected after surgery. The difference between preoperative and postoperative auditory perceptual assessment and nasalance scores for nasal and oral sentences was insignificant (p = 0.231, 0.442, 0.118 respectively. CONCLUSIONS: Transoral endoscopic partial adenoidectomy is a safe method; it does not worsen the speech of repaired cleft palate patients. It enables the surgeon to strictly inspect the velopharyngeal valve during the procedure with better determination of the adenoidal part that may contribute in velopharyngeal closure.

  12. Otitis media con efusión: estudio de casos y controles Otitis media with effusion: study of cases and controls

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    Sonia Grisales

    1992-01-01

    Full Text Available Se realizó un estudio en 66 niños y 34 niñas de 2 a 12 años. Cincuenta fueron casos de otitis media con efusión (OME y 50 controles. El grupo etario más numeroso fue el de dos años. Los síntomas y signos más frecuentes fueron otalgia y fiebre (70% e hipoacusia (40%. Veintinueve casos (58% y sólo 12 controles (24% presentaron adenoides hipertróficas (p < 0.01 . La pérdida auditiva fue significativamente mayor en el grupo de casos y las curvas timpanométricas se relacionaron directamente con ella. No se demostró que la alergia fuera un elemento importante en la génesis de la OME, a diferencia de la hipertrofia de adenoides que constituyó nuestro hallazgo más importante.

    Between July 1988 and May 1989 we studied 100 children aged2-14 years; there were fifty cases of otitis media with effusion (OME and fifty controls. Each group Included 33 boys and 17 girls. The predominant age group was 2 years. The most frequent clinical manifestations of OME were earache and fever (70% each and reduced hearing (40%. In 29 cases (58% and in only 12 controls (24% enlarged adenoids were found (p < 0.01 . impaired hearing was significantly most frequent In the cases and the tympanometric curves had direct relationship with reduced hearing. Despite Its high prevalence allergy was not found to be of importance In the etiology of OME; by contrast, enlarged adenoids were the most relevant determinant of this disease In our series.

  13. Evaluation of Ambulatory Patient Group (APG) Software Using CHAMPUS professional Services Claims Data (Beta Test)

    Science.gov (United States)

    1991-07-15

    MISCELLANEOUS GASTROINTESTI 31 0.01 31 0.01 167 TONSIL AND ADENOID PROCEDURES 349 0.08 349 0.08 168 HERNIA AND HYDROCELE PROCEDURES 196 0.05 196 0.04 169 SIMPLE... HYPERTROPHY 3 0.00 133 0.03 902 MALE REPRODUCTIVE DISEASES EXCEPT BENIGN 11 0.00 407 0.09 916 FEMALE GYNECOLOGIC DISEASE 31 0.01 3601 0.80 932 AIDS RELATED

  14. What Is the Role of Chlamydia pneumonia in Rhinosinusiits of Children?

    Directory of Open Access Journals (Sweden)

    2009-10-01

    Full Text Available Chlamydia pneumoniae is a common respiratory pathogen which is often found in our paediatric populations. Many patients with community-acquired pneumonia caused by C. pneumoniae have symptoms suggestive of sinusitis.the role of C. pneumonia in rhinosinusiits children (Meanage =4.3 ±2.5year. This case control study was done in the pediatric and ENT clinics of Hazrat Rasul Hospital in Tehran (2004-2005. This study based on diagnostic parametersfor rhinosinusitis cases and controls .Serum Specific antibodies (IgG & IgM against Chlamydia. Pneumonia detected in 51 cases and 31 controls. Nasopharyngeal swabsfor detection the Chlamydia.p -DNA by PCR used in all cases and controls. Acute infection (IgM obtained in 11%(6/51; previous immunity (IgG in none(0/51 of rhinosinusitis cases.Acute infection (IgM detected in 6.5% (2/31;previous immunity (IgG in 13.3%(4/31 of controls and dependent to age (P=000. Acute infection(IgMhad not significant difference (P= 0.7 between cases and controls but previous infection(IgG was significantly higher in controls (0.007.Active infection(DNA- PCR not obatained in cases . Acute infection (IgMin cases was twice higher than controls.None of cases had previous immunity to chlamydial infection (IgG. It was significantly lower thanhealthy controls (P =0.01. These serological results had different results in compare with its role in pneumonia study but it was closer to adenoid study (16%. Adenoid may act as a reservoir for bacteria causing sinusitis, lung and chronic ear infection.We recommend specific antibiotics for C. pneumonia in resistant sinusitis to usual drugs especially in cases accordance with adenoiditis and adenoid hypertrophy before surgery.

  15. Effect of Low Temperature Plasma Radiofrequency Ablation in the Treatment of Chronic Sinusitis in Children%腺样体低温等离子射频消融术对儿童慢性鼻窦炎治疗效果的影响

    Institute of Scientific and Technical Information of China (English)

    蔡灿辉

    2015-01-01

    目的:观察鼻内镜下腺样体消融术对儿童腺样体肥大伴慢性鼻窦炎的治疗效果。方法:将231例腺样体肥大伴慢性鼻窦炎的患儿分为两组,手术组116例,药物组115例,随访观察3个月,比较两组治疗情况。结果:手术组患儿总有效率为95.68%,比药物组的71.30%高(P<0.05)。结论:腺样体消融术对儿童慢性鼻窦炎的疗效具有积极影响。%Objective:To observe the therapeutic effect of nasal endoscopic adenoid ablation in the treatment of adenoid hypertrophy and chronic sinusitis in children.Method:231 cases of patients with chronic sinusitis of adenoid hypertrophy were divided into two groups,116 cases in the operation group,115 cases in the medicine group.Follow up observation for 3 months,the treatment of two groups were compared.Result:The total effective rate of the operation group was 95.68%,the medicine group was 71.30%,the total effect of the operation group was higher than that of the medicine group, the difference was statistically significant(P<0.05).Conclusion:The effect of adenoid ablation on chronic sinusitis in children has a positive effect on the treatment of chronic sinusitis in children.

  16. Helicobacterpylori in middle ear of children with otitis media with effusion

    Institute of Scientific and Technical Information of China (English)

    PARK Chul-won; CHUNG Jae-ho; MIN Hyun-jung; KIM Kyung-rae; TAE Kyung; CHO Seok-hyun; LEE Seung-hwan

    2011-01-01

    Background Otitis media with effusion (OME) is a common pediatric disease,but its pathogenesis remains uncertain.The relationship between OME and Helicobacter pylori (HP) is currently being studied,and a relationship has not yet been confirmed.The purpose of this study was to show that a relationship does exist between HP and OME.Methods The study consisted of 60 patients who were diagnosed with OME and had ventilation tube insertions with or without an adenoidectomy.This study included an additional 30 patients who had only received an adenoidectomy without being diagnosed with OME.The effusion samples were analyzed with polymerase chain reaction (PCR) and the campylobacter-like organism (CLO) test.The adenoid tissue samples were analyzed with the CLO test.Results Eighteen patients among the 60 patients (30%) tested positive for HP.In the cases with adenoids,15.6% of the OME patients and 13.3% of the adenoidectomy only patients were positive for HP.There were no differences between the prevalence of HP in the adenoids of OME patients and the patients without OME.Conclusion HP can be considered one of the causes of OME.

  17. Evaluation of p27 Expression in Salivary Gland Neoplasms; A Step Forward in Unveiling the Role of p27

    Science.gov (United States)

    Malgaonkar, Nikhil I.; Abuderman, Abdulwahab; Kharma, MY; Al-Maweri, SA; Alaizari, NA; Altamimi, MA.; Darwish, S.

    2016-01-01

    Introduction Salivary gland neoplasms are not uncommon lesions that are seen in the head and neck region. The role of cell cycle regulators as well as that of oncogenes remains unexplored in the pathogenesis of these neoplasms. Aim Present study was conducted to evaluate the expression of p27 in the three common salivary gland neoplasms. Materials and Methods A total of 34 cases (19 pleomorphic adenoma, 8 mucoepidermoid carcinoma and 7 adenoid cystic carcinoma) were included. The sections were subjected to p27 staining and rated for the expression. Results Of the total 52.6% of pleomorphic adenoma cases, 25% of mucoepidermoid carcinoma cases and only 14.2% of adenoid cystic carcinoma cases showed strong expression suggesting variable p27 expression in both malignant neoplasms. Normal salivary gland tissue was stained as a positive control for the evaluation. Conclusion The results of the study suggest an important role for p27 in pathogenesis of mucoepidermoid carcinoma as well as adenoid cystic carcinoma while its role in pathogenesis of pleomorphic adenoma remains questionable keeping in view the strong expression of p27 in the same. PMID:27630940

  18. Nasal nitric oxide in children with recurrent acute otitis media.

    Science.gov (United States)

    Torretta, S; Marchisio, P; Capaccio, P; Pignataro, L

    2016-01-01

    Recently, reduced Nasal nitric oxide (nNO) nNO levels have been reported in children with adenoidal hypertrophy predisposing to chronic nasosinusal inflammation. Given the strict anatomic and physiopathologic link between the nasopharyngeal and middle ear compartments, and considering the high prevalence of otitis prone children among those affected with chronic adenoiditis, we designed a study aimed to test any possible difference in nNO levels between non-allergic children with and without recurrent acute otitis media (RAOM) associated with chronic adenoiditis. The study involved 54 children with RAOM (44.4% males; mean age= 7.5±3.5 years) and 51 children without RAOM (47.4% males; mean age= 7.0±3.8 years). nNO levels were significantly reduced in children with RAOM compared to children without RAOM (676.9±250.7 ppb vs 831.8±320.4 ppb, respectively; p= 0.02). Our results could be related to reduced NO production by the ciliated paranasal, nasopharyngeal and middle ear epithelium and the impaired sinusal ostial and Eustachian tube patency due to chronic inflammation, and seem to confirm the involvement of NO pathway in recurrent upper airway infections related to impaired ciliated respiratory mucosa.

  19. The prognostic significance of β-catenin, cyclin D1 and PIN1 in minor salivary gland carcinoma: β-catenin predicts overall survival.

    Science.gov (United States)

    Schneider, Sven; Thurnher, Dietmar; Seemann, Rudolf; Brunner, Markus; Kadletz, Lorenz; Ghanim, Bahil; Aumayr, Klaus; Heiduschka, Gregor; Lill, Claudia

    2016-05-01

    Minor salivary gland carcinoma is a rare and heterogeneous type of cancer. Molecular prognostic and predictive markers are sparse. The aim of this study was to identify new prognostic and predictive markers in minor salivary gland carcinoma. 50 tissue samples of carcinomas of the minor salivary glands (adenoid cystic carcinoma n = 23, mucoepidermoid carcinoma n = 12, adenocarcinoma n = 10, carcinoma ex pleomorphic adenoma n = 2, salivary duct carcinoma n = 1, clear cell carcinoma n = 1, basal cell carcinoma n = 1) were immunohistochemically stained for β-catenin, cyclin D1 and PIN1. Expression patterns were analyzed and correlated to clinical outcome of 37 patients with complete clinical data. High expression of membranous β-catenin was linked to significantly better overall survival in patients with adenoid cystic carcinoma (log rank test, χ (2) = 13.3, p = .00397, Bonferroni corrected p = .024). PIN1 and cyclin D1 did not show any significant correlation to patients' clinical outcome. Expression of β-catenin in adenoid cystic carcinoma of the minor salivary glands significantly correlates with better overall survival. Hence, evaluation of β-catenin might serve as a clinical prognostic marker.

  20. Maspin and MCM2 immunoprofiling in salivary gland carcinomas

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    Helmy Iman M

    2011-09-01

    Full Text Available Abstract Background The pathogenesis of salivary gland carcinomas is very complex and prognostic markers are difficult to find in these carcinomas of which the different subtypes have varying malignant potential. The study was conducted to examine the cellular distribution of maspin and MCM2 in salivary gland carcinomas and their value to predict lymph node metastasis. Materials and methods Fifty three paraffin blocks of different lesions (15 muco-epidermoid carcinoma, 14 adenoid cystic carcinoma, 3 epi-myoepithelial carcinoma, 5 salivary duct carcinoma, 5 malignant pleomorphic adenoma, 6 polymorphous low grade adenocarcinoma and 5 acinic cell carcinoma were prepared for immunohistochemical staining with maspin and MCM2 antibodies. ANOVA and Pearson correlation tests were used for the statistical analysis of the results. Results All salivary gland carcinomas express maspin and MCM2 with variable cellular localization. There was a significant difference in the expression of each antibody between mucoepidermoid carcinoma, adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. No association was found between examined markers and lymph node metastasis. Conclusions Salivary gland carcinomas express maspin and MCM2 with variable levels and cellular localization, consisting important markers of biological behavior in these tumors. The level of MCM2 expression can be used in the differential diagnosis of adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. Further study with large sample size is recommended to assess their value in prediction of lymph node metastasis.

  1. Effect of etiology of mouth breathing on craniofacial morphology

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    Mohammadreza Majidi

    2008-07-01

    Full Text Available Introduction: Nasal septal deviation and hypertrophy of the adenoids and palatine tonsils are two common causes of nasopharyngeal obstruction and consequently mouth breathing in children. It is accepted that chronic mouth breathing influences craniofacial growth and development. The aim of this study was to evaluate the differences of craniofacial morphology in children with two different etiological factors of mouth breathing. Materials and Methods: Study design: cross sectional. The research was conducted between 2005-2007 on 47 predominantly mouth breathing patients aged 6-10 years. After otorhinolaryngologic examination, patients were divided into two groups based on the etiology of nasopharyngeal obstruction: group 1, with Adenoid hypertrophy and group 2 with nasal septal deviation. Lateral cephalometric radiographs were obtained to assess craniofacial development. Data gained were statistically evaluated by Mann-Whitney and T-student tests. Results: With respect to the inclination of the mandibular and palatal planes, anteroposterior relationship of maxilla and mandible to the cranial base, and indexes of facial height proportions, no significant differences were observed between two groups of children with mouth breathing. Only the gonial and craniocervical angle measurements were significantly larger in children with adenoid hypertrophy (P

  2. The impact of laronidase treatment in otolaryngological manifestations of patients with mucopolysaccharidosis

    Directory of Open Access Journals (Sweden)

    Ana Paula Fiuza Funicello Dualibi

    Full Text Available ABSTRACT INTRODUCTION: Mucopolysaccharidosis (MPS is a lysosomal storage disease caused by deficiency of a-l-iduronidase. The otolaryngological findings include hearing loss, otorrhea, recurrent otitis, hypertrophy of tonsils and adenoid, recurrent rhinosinusitis, speech disorders, snoring, oral breathing and nasal obstruction. OBJECTIVE: To evaluate the impact of enzymatic replacement therapy with laronidase (Aldurazyme(r in patients with mucopolysaccharidosis (MPS I, regarding sleep and hearing disorders, and clinical manifestations in the upper respiratory tract (URT. METHODS: Nine patients with MPS I (8 Hurler-Scheie, and 1 Scheie phenotypes of both sexes, ages ranging between 3 and 20 years, were included in this study. Patients were evaluated between seven and 11 months before the treatment and between 16 and 22 months after the onset of the enzymatic replacement. They were all submitted to a clinical and otolaryngological evaluation, including nasofibroscopical, polysomnographic and audiologic exams. RESULTS: The results' data showed decreasing of the frequency of ear, nose and throat infections, with improvement of the rhinorrhea and respiratory quality. No remarkable changes were observed regarding macroglossia and tonsil and adenoid hypertrophy. Audiometric and polysomnographic evaluations did not show statistical significance. CONCLUSION: Enzymatic replacement therapy in patients with mucopolysaccharidosis I provides control of recurrent URT infections, rhinorrhea and respiratory quality, however it is does not seem to improve audiologic and polisomnographic parameters, with no effect on adenoid and tonsils hypertrophy and macroglossia.

  3. 海藻玉壶汤合苍耳子散加减治疗腺样体肥大疗效观察

    Institute of Scientific and Technical Information of China (English)

    於志娟

    2015-01-01

    目的:观察海藻玉壶汤合苍耳子散加减治疗腺样体肥大的疗效.方法:60例随机分为两组各30例,治疗组用海藻玉壶汤合苍耳子散加减治疗,对照组用西医治疗.结果:总有效率治疗组93.3%,对照组46.7%,差异有统计学意义(P<0.05).结论:海藻玉壶汤合苍耳子散加减治疗腺样体肥大有明显促进腺样体缩小的作用,疗效确切.%Objective:To observe the therapeutic effect on adenoid hypertrophy treated by modified Haizao Yuhu Decoction combined with Xanthium Powder. Method: 60 cases were divided into 2 groups evenly in random. The treatment group were treated with modified Haizao Yuhu Decoction combined with Xanthium Powder while the control group were treated with western medicine. Result: The total effective rate of the treatment group was 93.3% while that of the control group was 46.7%. There were significant differences between the two groups(P<0.05). Conclusion: Modified Haizao Yuhu Decoction combined with Xanthium Powder has exact therapeutic effect on adenoid hypertrophy in promoting reduction of adenoid.

  4. Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck Cancer

    Science.gov (United States)

    2014-11-07

    Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage

  5. Evaluation of the related dangerous factors in children with obstructive sleep apnea hypopnea syndrome%儿童阻塞性睡眠呼吸暂停低通气综合征危险因素的评估

    Institute of Scientific and Technical Information of China (English)

    李俊义; 徐华林; 姜彦; 李娜

    2012-01-01

    [Objective] To study the dangerous factors in children with obstructive sleep apnea hypopnea syndrome (OSAHS),and to explore whether obesity and the tonsil and/or adenoid hypertrophy would cause obstructive sleep apnea hypopnea syndrome. [Methods] The body mass index(BMI) and the tonsil and adenoid size were evaluated on 182 OS-AHS and 160 non-OSAHS children. All children were examined by polysomnography(PSG). [Results] Among OSAHS, BMI and the tonsil and adenoid size were significantly higher than the control group of children's. In addition,OSA score and apnea hypopnea index(AHI) ,LSaO2 showed a positive correlation. Obesity, tonsillar hypertrophy, and adenoid hypertrophy were the dangerous factors for OSAHS. [Conclusion] OSAHS had impact on children's quality of life seriously. It indicated that there were certain relations between pathogenetic factors and obesity, tonsillar hypertrophy and adenoid hypertrophy, we can pass from the etiology to control the occurrence of OSAHS in children.%[目的]研究儿童阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)中的危险性因素,并探讨肥胖、扁桃体肥大及腺样体肥大与儿童OSAHS的相关性. [方法]对182例儿童OSAHS患者及160例无OSAHS儿童进行体质指数(body mass index,BMI)、扁桃体大小及腺样体大小进行评价.对全部儿童进行多导睡眠监测(polysomnography,PSG),以无OSAHS儿童作为对照组. [结果] 患有OSAHS儿童的体质指数、扁桃体肿大程度及腺样体肥大显著高于对照组儿童,并且两组患儿的OSA评分、呼吸暂停指数、最低血氧饱和度的差异有统计学意义(P<0.05). [结论]儿童OSAHS严重影响儿童的生活质量,肥胖、扁桃体肥大以及腺样体肥大均是儿童OSAHS的危险因素.可以通过从病因着手控制儿童OSAHS的发生.

  6. 鼻内镜下等离子小儿腺样体切除临床观察%Endoscopy-assisted Plasm Radiofrequency Adenoidectomy in Children

    Institute of Scientific and Technical Information of China (English)

    许建峰; 王英; 吴建华; 王会河; 贾玉芬; 王建华

    2008-01-01

    Objective To observe the effects of plasm radiofrequency therapy in the treatment of adenoid hypertrophy under endoscope.Methods Sixty-one children of hypertrophied adenoid with otitis media with effusion,OSAHS and pediatric chronic rhinosinusitis were treated under endoscopy-assisted plagm radiofrequency therapy.Results All children had been followed for 6~18 months,20 children(40ears)with otitis media with effusion cured,one uncured;25 children with OSAHS and 15 with pediatric chronic rhinosinusitis cured.No adenoid wag residual and no complication occurred.Conclusion Utilizing plagm radiofrequency in the treatment of adenoid hypertrophy under endoscope had the advantages of direct and clear view of surgical area that allows the surgeons to remove adenoids accurately and avoid damage of normal nasopharyngeal structures,obvious curative effect,easy to operate and high safety,mini invagive and with few complication.%目的 探讨鼻内镜下应用等离子技术切除肥大腺样体的疗效.方法 对61例腺样体肥大合并分泌性中耳炎、OSAHS和慢性鼻-鼻窦炎的患儿在鼻内镜直视下行等离子性等离子腺样体切除术,并辅以鼓膜穿刺、扁桃体切除、上颌窦穿刺等治疗,观察术后疗效.结果 术后随访6~18个月,21例(41耳)分泌性中耳炎患儿中20例痊愈,1例未愈;25例OSAHS和15例慢性鼻-鼻窦炎患儿均痊愈.结论 鼻内镜下应用等离子技术切除腺样体具有视野清楚、创伤小、定位准确、安全性高,是一种较先进的治疗方法.

  7. Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy

    Science.gov (United States)

    2016-02-04

    Mucositis; Oral Complications; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid

  8. Male breast cancer: 22 case reports at the National Hospital of Niamey- Niger (West Africa Le cancer du sein chez l'homme: à propos de 22 cas a l'Hôpital National de Niamey- Niger (Afrique de l'Ouest

    Directory of Open Access Journals (Sweden)

    Nouhou Hassane

    2009-11-01

    masculin présentant un cancer de sein pendant 17 ans de 1992 à 2006 avec preuve histologique. RESULTATS : La série comportait 22 cas. L’age moyen était de 52,8 ans (Extrêmes : 28 et 80 ans. Le CSH représentait 5,7% des cancers du sein. Les tumeurs étaient cliniquement avancées avec des formes ulcéro-hémorragiques et inflammatoires T3 (31.9% and T4 (59.1%. La majorité des patients provenaient des zones rurales (63.6%. Les signes évoluaient de 1 à 7 ans. L’examen histologique a retrouvé un carcinome canalaire infiltrant dans 14 cas (63,6%, le fibrosarcome dans 3 cas (13,6%, le carcinome papillaire dans 2 cas (9% et les autres types dans 1 cas chacun (4,6% : le carcinome lobulaire, carcinome médullaire, le carcinome épidermoïde .La mastectomie radicale (Patey ou Halsted avec curage ganglionnaire axillaire été réalisée dans 19 cas (86,4%, et dans 3 cas (13,6% une exérèse incomplète. L’évolution : dans l’étude rétrospective 13 patients perdus de vue 6 mois après la mastectomie. Dans l’étude prospective après un recul de 10 à 36 mois il a été enregistré 4 décès (50% et 4 patients sont vivant et un cas avec de récidive locale et métastases hépatiques. CONCLUSION : Le CSH est rare mais non exceptionnel. Le stade est évolué au moment diagnostic et le pronostic est grave. Dans notre environnement la mastectomie radicale constitue dans la plupart des cas le seul moyen thérapeutique lié au faible accès de la radio chimiothérapie.

  9. WholeBbody Positron-Emission-Tomography (WB-PET) in oncology; Ganzkoerper-Positronen-Emissions-Tomographie (GK-PET) in der Onkologie

    Energy Technology Data Exchange (ETDEWEB)

    Feine, U. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Lietzenmayer, R. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Mueller-Schauenburg, W. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Geiger, L. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Hanke, J.P. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Weisser, G. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Woehrle, H. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany)

    1996-02-01

    - Malignes Lymphom - Mamma-Carcinom - Schilddruesen-Carcinom und einer fuenften Gruppe, in der 24 verschiedene maligne Tumoren untersucht worden waren, ergaben sich eine Sensitivitaet von 88%, eine Spezifitaet von 80% und eine Treffsicherheit von 90%. Falsch negativ waren Herde <6-8 mm im Durchmesser, meist Lu