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Sample records for carcinoma present status

  1. Radiofrequency ablation of renal cell carcinoma under CT guidance. Present and Future status

    International Nuclear Information System (INIS)

    Nasu, Yasutomo; Kobayashi, Yasuyuki; Uematsu, Katsutoshi; Saika, Takashi; Kumon, Hiromi; Gohara, Hideo; Mimura, Hidefumi; Kanazawa, Susumu

    2011-01-01

    At Okayama University, radiofrequency ablation (RFA) of renal cell carcinoma was performed in May 2002 as the initial case in Japan. In 2004, it was regarded as an advanced medical technique by the Japanese authority. Since then, RFA has been actively performed for renal cell carcinoma not only at the primary site but also at the metastatic site, including the lung and bone. The clinical outcome has been compatible with other institutes and no serious adverse events have occurred. From the view paint of fusing technical innovation with medical safety, this treatment is a potent therapeutic option for renal cell carcinoma. In the era of laparoscopic surgery, RFA is indicated for cases with von Hippel-Lindau disease (VHL), recurrence after partial nephrectomy, a single kidney and intolerance to general anesthesia, due to its technical advantage in that RFA can be repeated. In this review, the current clinical outcome is reported and future prospects are discussed as to whether it can be the safest and most concrete treatment for renal cell carcinoma in the 21 st century. (author)

  2. Present status and future of high-precision image guided adaptive brachytherapy for cervix carcinoma

    International Nuclear Information System (INIS)

    Poetter, Richard; Kirisits, Christian; Fidarova, Elena F.; Dimopoulos, Johan nes C. A.; Berger, Daniel; Tanderup, Kari; Lindegaard, Jacob C.

    2008-01-01

    Introduction. Image guided adaptive brachytherapy (IGABT) for cervical cancer, using mainly MRI, is an evolving method, increasingly replacing the 2D approach based on conventional radiography. During the complex 4D chain of this procedure image-assistance is provided for disease assessment, provisional treatment planning ('pre-planning'), applicator placement and reconstruction, as well as for contouring, definitive treatment planning and quality control of dose delivery. With IGABT changes of topography adjacent to the applicator, caused by tumour regression, oedema, organ changes and dilation are identified. Thus, the CTV for IGABT is primarily based on the tumour volume at the time of BT and takes into account both time and spatial domains. IGABT requires systematic concepts for target, OAR, biological modelling, DVH analysis, and dose-volume-adaptation. Methods and Results. This report focuses on the advantages and uncertainties, dose-effect relations and clinical results of the IGABT procedure addressing the current status and future perspectives. Uncertainties during the 4D chain of IGABT are mainly related to target contouring, applicator reconstruction, as well as to inter-fraction, intra-fraction and inter-application variability, as caused by tumour response and organ changes. Different from EBRT where set-up uncertainties are compensated by adding a margin to the CTV, no margins to the lateral and anterior-posterior directions can be used for IGABT. Discussion. By 3D treatment planning for IGABT significant improvement of the DVH parameters is achieved compared to 2D library plans. In small tumours the benefit is primarily obtained by a decrease of dose to nearby OAR while in large tumours the use of supplementary interstitial techniques and optimization may double the target volume that can be treated at a therapeutic dose level. The clinical impact of IGABT could recently be demonstrated by the establishment of some correlations between target- and

  3. PRESENT STATUS IN INDIA

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. PRESENT STATUS IN INDIA. FIXED LINES – 36 MILLION. MOBILE CONNECTIONS – 14 MILLION. TELEDENSITY APPROXIMATELY 5. INTERNET CONNECTIONS – 5 MILLION. INTERNET USERS NEARLY – 25 MILLION.

  4. Carcinoma caecum - a rare presentation

    International Nuclear Information System (INIS)

    Ali, T.; Mudasser, S.; Mudsser, S.; Sarwar, M.

    2010-01-01

    Caecal and right sided colonic cancers mostly present with fatigue, weakness and iron deficiency anemia. Such tumours rarely perforate posteriorly and involve the retroperitoneum. We report a case of an old Omani lady who came with insidious sign and symptoms of perforated caecum leading to retroperitoneal collection and necrotizing fasciitis of abdominal wall due to carcinoma of caecum. She underwent surgery but despite active intervention, she died because of septicemic shock. (author)

  5. Sebaceous carcinoma. Presenting a case

    International Nuclear Information System (INIS)

    Plaza, Jaime; Salinas, Ana; Cabrera, Raul; Vargas, Martha; Caicedo, Eduardo

    2002-01-01

    Patient of feminine sex of 65 years of age with tumor of approximately 1.5 cm of diameter, located in the right palpebral region, being put under ample exeresis of a tumor more pastia, whose anatomopathology result revealed sebaceous carcinoma with free edges. This is a rare malignant carcinoma that originates in perioculars sebaceous glands like the glands of Meibomio that affects the superior flicker. Clinically it appears like a small nodule, of small growth and its diagnose is based on a high degree of suspicion in any chronic process of the flicker. The selection processing is the surgery, the x-ray, radiotherapy is useful in the postoperating attention and like palliative therapy. (The author)

  6. Present status of dibaryons

    International Nuclear Information System (INIS)

    Locher, M.P.

    1981-01-01

    In the present notes the author tries to assess the situation regarding dibaryons in the various channels with baryon number two, emphasizing the problems and discussing in greater detail the most recent developments since the Versailles Conference. One of the motivations for the present search of B=2 states is the possibility of colored subclusters for systems with six quarks which cannot occur for ordinary baryons or mesons. (Auth.)

  7. Present energy status

    Energy Technology Data Exchange (ETDEWEB)

    Desprairies, P

    1988-04-01

    This paper reviews the past and present situation of the World Oil Market and assumes future trends and possible future evolution. Low oil prices between 1950 and 1973 have contributed to an exceptional growth of oil demand during more than 20 years which was more and more supplied by OPEC. The oil shocks of 1973 and 1979 have dramatically changed this situation. Some of the most important changes have been the emergence of non-OPEC new oil producers, the growth of substitute energies, especially natural gas and nuclear power, on the supply side; and substantial decrease of energy consumption in many industrialized countries which has greatly reduced oil demand to OPEC on the demand side. Today this situation seems somewhat stabilized (after the reversal of world oil prices in 1986) and OPEC is producing around 18 million b/day as against a producing capacity of about 30 million b/day. It is generally considered that in coming years oil prices will remain relatively low (or occasionally even become lower than today) due to excess oil production capacity and relative abundance of other types of energy. However, many experts think that these trends can be reversed when oil supply will more and more concentrate again in the Middle East; but it is hard to say if this will begin in 1995, 2000, 2010.

  8. MAMMARY TUBERCULOSIS PRESENTING AS CARCINOMA

    African Journals Online (AJOL)

    She was otherwise well wizh no symptoms referable to other systems. On examination .... cardiac failure. The other ... but chronic oedema of the right arm of moderate degree was present. .... a tuberculous ulcer on the dorsum of the hand, followed ... venous system may also lead to haematogenous dissemination, producing ...

  9. NUT carcinoma presenting in the palate

    DEFF Research Database (Denmark)

    Bjornstrup, Libana Raffoul; Reibel, Jesper; Kiss, Katalin

    2017-01-01

    NUT carcinomas (NC) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis (NUT) located on chromosome 15q14. This article presents a case of a 60-year-old woman diagnosed with NC presenting as a fast growing primary tumo...

  10. Present status of CP violation

    International Nuclear Information System (INIS)

    Ng, J.N.

    1989-06-01

    A review of the status of CP violation in kaons is given. Status of our knowledge of quark mixing angles in the standard six quark model is presented. The role Β d o - Βd o transition plays in this study is examined. A comparison of the estimates of CP violation effects from models beyond the standard one is given. Other experiments that have the capability of testing different CP violation models are also discussed. (Author) 35 refs., 6 figs., tab

  11. Renal cell carcinoma presenting as mandibular metastasis

    Directory of Open Access Journals (Sweden)

    Hassan Ahmadnia

    2013-01-01

    Full Text Available Renal clear cell carcinoma (RCC has different manifestations, including uncommon metastasis and paraneoplastic syndromes. Here we report a rare case of RCC presenting as metastasis to the mandible. A 57-year-old patient with mandibular swelling was referred to the dentist. After necessary evaluations, an incisional biopsy of mandible showed metastatic RCC. The patient was referred to the urologist. The patient underwent right radical nephrectomy. Pathological examination showed clear renal cell carcinoma. Every abnormal bone lesion in the oral cavity should be evaluated carefully and the possibility of a malignant lesion should always be considered.

  12. Present status of processing method

    Energy Technology Data Exchange (ETDEWEB)

    Kosako, Kazuaki [Sumitomo Atomic Energy Industries Ltd., Tokyo (Japan)

    1998-11-01

    Present status of processing method for a high-energy nuclear data file was examined. The NJOY94 code is the only one available to the processing. In Japan, present processing used NJOY94 is orienting toward the production of traditional cross section library, because a high-energy transport code using a high-energy cross section library is indistinct. (author)

  13. Clinical presentation of renal cell carcinoma

    International Nuclear Information System (INIS)

    Rehman, R.A.; Ashraf, S.; Jamil, N.

    2015-01-01

    Most common malignant tumour of the kidney is Renal Cell Carcinoma (RCC) and is known for its unpredictable clinical behaviour. Aetiology and risk factors are not completely understood. Extensive workup is being done in the understanding of the disease, especially to diagnose early and to treat promptly. The objective of this study was to determine the clinical presentation and pathological pattern of RCC. Methods: After approval from ethical committee a retrospective review of records was conducted extending from January 2012 to January 2014 to identify clinical characteristics of renal cell carcinomas. The study included all renal cancer patients presented to Sheikh Zayed Hospital Lahore with in this specified period. The data was retrieved regarding, history, physical examination and necessary investigations such as ultrasonography of abdomen and pelvis and CT scan of abdomen and pelvis. Results: There were total of 50 cases. The male to female ratio was 3:2. Mean age of patients were 52.38 (18-93) years old. Most common clinical presentation was gross haematuria(66%).The mean tumour size was 8.34 (3-24) cm. Tumour histology were clear cell (84%), papillary transitional cell carcinoma (12%) and oncosytoma contributed 4%. Conclusion: We observed that large number of the patients with RCC presented with haematuria and most of them were male. Common pathological type was clear cell carcinoma. (author)

  14. Carcinoma Gall Bladder: Past, Present, and Future

    Directory of Open Access Journals (Sweden)

    Ghosh Y

    2014-12-01

    Full Text Available Carcinoma gall bladder is a very aggressive disease with poor outcomes. Despite achievements in the field of advanced imaging techniques, there is a very high mortality rate of the disease Cancer is the second most common disease in India responsible for maximum mortality with about 0.3 million deaths per year. The magnitude of cancer problem in the Indian Sub-continent (sheer numbers is increasing due to poor to moderate living standards and inadequate medical facilities. Women are more commonly affected than men. The peak incidence occurs in people in their 60s, but the disease age range is from 29 to 90 years of age and there is great geographic and ethnic variation. Carcinoma gall bladder, a disease of old age, is now found in the younger age group and presents with greater ferocity.

  15. RTNS-II: present status

    International Nuclear Information System (INIS)

    Heikkinen, D.W.; Logan, C.M.

    1980-10-01

    The present status of the RTNS-II facility is described and typical operating parameters are given. A brief discussion is given of the methods used in production of the TiT 2 targets as well as their performance and tritium handling at RTNS-II. The various types of non-interactive beam diagnostics presently in use at the neutron sources are outlined. The on-line computer system which provides a time history of an irradiation and records target performance is described. Examples are listed of several representative experimental programs which have been carried out thus far at RTNS-II. These include both active and passive experiments. Finally, several of the major improvements to the facility made since the beginning of the experimental program are given

  16. Influence of radiochemotherapy on the nutritional status of patients with advanced carcinoma of the head and neck and presentation of a new method for imaging oral mucositis (digital dermascope system)

    International Nuclear Information System (INIS)

    Galvan, O.

    1998-12-01

    The maintenance of nutritional status is a serious problem for patients suffering from head and neck cancer. Malnutrition leads to prolongation of hospitalisation and is an important risk factor in the development of postoperative complications and infections. This study was conducted to evaluate the consequences of radiochemotherapy on the nutritional status. Furthermore the timing for initiation of nutritional support was analysed. 23 patients with advanced carcinoma of the head and neck were studied prospectively. The treatment protocol consisted of conventional radiotherapy combined with infusional 5-fluorouracil and mitomycin-C. Anthropological, biochemical and immunological parameters and the Hackl-score were used to define malnutrition. The WHO-criteria and the digital dermascope-system were used for scoring and imaging oral mucositis. The dermascope-camera-system allows diagnosis of early mucosal changes and provides objective information on the patients' oral health. At the time of diagnosis malnutrition was present in some patients. Generally the nutritional status worsened until the beginning of therapy. After three weeks of treatment moderate or severe malnutrition and immunsuppression occurred in most of the patients. Analysis of the Hackl-score revealed an absolute indication for nutritional support in 82.6 %. At the end of treatment nutritional therapy was indicated in 100 % of the patients. Nutritional intervention was initiated too late in the clinical course. Prophylactic nutritional therapy is indicated when radiochemotherapy is planned for patients with advanced head and neck cancer.(author)

  17. Influence of radiochemotherapy on the nutritional status of patients with advanced carcinoma of the head and neck and presentation of a new method for imaging oral mucositis (digital dermascope system)

    International Nuclear Information System (INIS)

    Galvan, O.

    1998-12-01

    The maintenance of nutritional status is a serious problem for patients suffering from head and neck cancer. Malnutrition leads to prolongation of hospitalization and is an important risk factor in the development of postoperative complications and infections. This study was conducted to evaluate the consequences of radiochemotherapy on the nutritional status. Furthermore the timing for initiation of nutritional support was analyzed. 23 patients with advanced carcinoma of the head and neck were studied prospectively. The treatment protocol consisted of conventional radiotherapy combined with infusional 5-fluorouracil and mitomycin-C. Anthropological, biochemical and immunological parameters and the Hackl-score were used to define malnutrition. The WHO-criteria and the digital dermascope-system were used for scoring and imaging oral mucositis. The dermascope-camera-system allows diagnosis of early mucosal changes and provides objective information on the patients' oral health. At the time of diagnosis malnutrition was present in some patients. Generally the nutritional status worsened until the beginning of therapy. After three weeks of treatment moderate or severe malnutrition and immunsuppression occurred in most of the patients. Analysis of the Hackl-score revealed an absolute indication for nutritional support in 82,6 %. At the end of treatment nutritional therapy was indicated in 100 % of the patients. Nutritional intervention was initiated too late in the clinical course. Prophylactic nutritional therapy is indicated when radiochemotherapy is planned for patients with advanced head and neck cancer. (author)

  18. Carcinoma of the bladder - the present situation

    Energy Technology Data Exchange (ETDEWEB)

    Backhouse, T W [9050155GB:Coventry and Warwickshire Hospital (UK). Dept. of Radiotherapy and Oncology

    1979-04-01

    Occupational exposure to carcinogens can result in the development of malignancies after a latent period as long as 45 years. New cases are therefore still being detected, although known carcinogens have been banned for some 30 years. Presenting symptoms, investigative techniques, types of bladder carcinoma and methods of spread are all discussed. Criteria for treatment selection are based on the stage of development of the tumor. Radiotherapy requires preliminary localization of the bladder in relation to external marks. A mercury-filled balloon is carefully positioned in the bladder at the internal meatus, and fluoroscopy provides films which are used in final calculations of dose distribution. A dose of 6000 rad is given by a 300 deg rotational technique over 6 weeks to the tumor volume contained within the 90% isodose curves. The advantages of the technique are discussed, and survival rates given for different tumors at various stages of development.

  19. Merkel cell carcinoma: A rare presentation

    Directory of Open Access Journals (Sweden)

    Prosanta Kumar Bhattacharjee

    2014-01-01

    Full Text Available A 33-year-old man presented with a lump at the right side of chest wall of 4 months duration which started bleeding suddenly from an ulcer at its center. Examination revealed a globular ulcerated mass 2 cm in diameter, on the anterior axillary fold, with adherent clot at its center. No regional lymphadenopathy was noted. Wide local excision with 2 cm margin was done. Biopsy report revealed malignant small round-cell tumor. Immunohistochemistry showed it to be cytokeratin-20-positive and S100-negative, suggesting the diagnosis of Merkel cell carcinoma. The patient did not receive any other adjuvant therapy. He is being followed-up for the last 4 years and has shown no features of recurrence so far.

  20. Papillary thyroid carcinoma presenting as an asymptomatic pelvic bone metastases

    Directory of Open Access Journals (Sweden)

    Siddiq S

    2010-05-01

    Full Text Available Thyroid carcinoma is rare comprising 1% of all malignancies and commonly presents as a neck lump. Papillary thyroid carcinoma unlike follicular thyroid carcinoma tends not to metastasise to distant sites.We present a case of papillary thyroid carcinoma presenting as a solitary asymptomatic pelvic bone metastases and highlight current management of bone metastases. A 59-year old female was found on abdominal computerised tomography to have an incidental finding of a 4.5 cm soft tissue mass in the right iliac bone. Biopsy of the lesion confirmed metastatic thyroid carcinoma. There was no history of a neck lump, head and neck examination was normal. Further imaging confirmed focal activity in the right lobe of the thyroid. A total thyroidectomy and level VI neck dissection was performed and histology confirmed follicular variant of papillary carcinoma.Early detection of bone metastases have been shown to improve prognosis and thyroid carcinoma should be considered as a potential primary malignancy.

  1. Synchronous presentation of nasopharyngeal and renal cell carcinomas

    Directory of Open Access Journals (Sweden)

    Cem Boruban

    2006-06-01

    Full Text Available We report a rare case of synchronous presentation of nasopharyngeal and renal cell carcinomas in a-50-year old male patient with long standing smoking history. The patient was initially presented with a diagnosis of nasopharyngeal carcinoma. During staging process, the abdominal computed tomography detected a right renal solid mass, 6.5 cm in diameter, originating from posterior portion of the right renal cortex. Right radical nephrectomy was performed and pathological examination revealed renal cell carcinoma. Smoking was thought to be a risk factor for both cancers. Systemic evaluation of kidney should not be discarded in patients diagnosed with nasopharyngeal carcinoma living in western countries with a smoking history.

  2. Peritoneal carcinomatosis: an unusual presentation of fibrolamellar hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Vicente, R.; Garcia-Gutierrez, J. A.; Fernandez, A.; Santalla, F.

    2001-01-01

    Fibrolamellar hepatocellular carcinoma is an uncommon malignant tumor with characteristic clinical, radiological and histopathological features that is usually associated with a more favorable natural course and greater survival than more common variants of hepatocellular carcinoma. We describe an atypical case of a fibrolamellar hepatocellular carcinomas sowing aggressive behaviour in a 20-year-old woman. The lesion presented with massive ascites, and imaging studies revealed extensive peritoneal metastatic spread. (Author) 8 refs

  3. Present status of Tokamak research

    International Nuclear Information System (INIS)

    Basu, Jayanta

    1991-01-01

    The scenario of thermonuclear fusion research is presented, and the tokamak which is the most promising candidate as a fusion reactor is introduced. A brief survey is given of the most noteworthy tokamaks in the global context, and fusion programmes relating to Next Step devices are outlined. Supplementary heating of tokamak plasma by different methods is briefly reviewed; the latest achievements in heating to fusion temperatures are also reported. The progress towards the high value of the fusion product necessary for ignition is described. The improvement in plasma confinement brought about especially by the H-mode, is discussed. The latest situation in pushing up Β for increasing the efficiency of a tokamak is elucidated. Mention is made of the different types of wall treatment of the tokamak vessel for impurity control, which has led to a significant improvement in tokamak performance. Different methods of current drive for steady state tokamak operation are reviewed, and the issue of current drive efficiency is addressed. A short resume is given of the various diagnostic methods which are employed on a routine basis in the major tokamak centres. A few diagnostics recently developed or proposed in the context of the advanced tokamaks as well as the Next Step devices are indicated. The important role of the interplay between theory, experiment and simulation is noted, and the areas of investigation requiring concerted effort for further progress in tokamak research are identified. (author). 17 refs

  4. Source rock hydrocarbons. Present status

    International Nuclear Information System (INIS)

    Vially, R.; Maisonnier, G.; Rouaud, T.

    2013-01-01

    This report first presents the characteristics of conventional oil and gas system, and the classification of liquid and gaseous non conventional hydrocarbons, with the peculiar case of coal-bed methane. The authors then describe how source rock hydrocarbons are produced: production of shale oils and gases (horizontal drilling, hydraulic fracturing, exploitation) and of coal-bed methane and coal mine methane. In the next part, they address and discuss the environmental impact of source rock hydrocarbon production: installation footprint, water resource management, drilling fluids, fracturing fluids composition, toxicity and recycling, air pollution, induced seismicity, pollutions from other exploitation and production activities. They propose an overview of the exploitation and production of source rock gas, coal-bed gas and other non conventional gases in the world. They describe the current development and discuss their economic impacts: world oil context and trends in the USA, in Canada and other countries, impacts on the North American market, on the world oil industry, on refining industries, on the world oil balance. They analyse the economic impacts of non conventional gases: development potential, stakes for the world gas trade, consequence for gas prices, development opportunities for oil companies and for the transport sector, impact on CO 2 emissions, macro-economic impact in the case of the USA

  5. Fibrolamellar carcinoma: an unusual clinico-radiological presentation

    International Nuclear Information System (INIS)

    Gupta, Preeti; Dhar, Sunanda; Strickland, Nicola H.

    1999-01-01

    We report a case of fibrolamellar carcinoma presenting in a 26-year old female. The patient had gross ascites at presentation. Imaging studies (ultrasonography and computed tomography) strongly suggested extensive intraperitoneal drop metastases

  6. Laryngeal carcinoma presenting as polymyositis: A paraneoplastic syndrome

    Directory of Open Access Journals (Sweden)

    Ritesh Sahu

    2016-01-01

    Full Text Available Laryngeal carcinoma is rarely associated with paraneoplastic syndrome. Inflammatory myopathy presenting as paraneoplastic event is commonly associated with carcinomas of ovary, lung, pancreas, stomach, colorectal, and non-Hodgkin′s lymphoma. We report a case of elderly male, who presented with proximal muscle weakness and found to be associated with laryngeal carcinoma. Diagnosis of polymyositis (PM was confirmed based on clinical features, laboratory test, and muscle biopsy. Exclusion of other commonly associated malignancies was done. This patient improved gradually after 6 months of immunosuppressive therapy and management of underlying cancer.

  7. Current status of superficial pharyngeal squamous cell carcinoma in Japan.

    Science.gov (United States)

    Rikitake, Ryoko; Ando, Mizuo; Saito, Yuki; Yoshimoto, Seiichi; Yamasoba, Tatsuya; Higashi, Takahiro

    2017-10-01

    To investigate the status and treatment of superficial pharyngeal squamous cell carcinoma in Japan. We analyzed all cases diagnosed between 2011 and 2013, as recorded in the national database of hospital-based cancer registries. We extracted data on patient sex, age, tumor locations, histology, presentation routes, initial treatments, and TNM stages. Additionally, we compared the characteristics of pharyngeal carcinoma to those of esophageal cancer. A total of 16,521 oropharyngeal and hypopharyngeal cancers from 409 institutions were included. Diagnosis of Tis tumors was infrequent, and both cancers were likely to be diagnosed at an advanced stage (n = 866, 5.3%). Tis diseases were the most commonly detected during follow-up examinations for other diseases (n = 608, 70%). While more oropharyngeal Tis patients were men compared to T1-4 patients (88 vs 82%, respectively), hypopharyngeal cancer patients comprised an equally high proportion of men (94 vs 92%, respectively). The most common location of oropharyngeal Tis tumors was the posterior wall (32%), whereas T1-4 tumors were most commonly found on the lateral wall (36%). In hypopharyngeal cancer, both Tis and T1-4 were most commonly located in the pyriform sinus (62%). The proportion of Tis tumors diagnosed at individual institutions showed a positive correlation with the number of endoscopic treatments (r = 0.32, P squamous cell carcinoma patients in Japan. Further improvements in early diagnosis and standardized treatments are warranted.

  8. Present status and physics prospects of SSC

    International Nuclear Information System (INIS)

    Sugimoto, Shojiro

    1990-01-01

    Physics prospects of Superconducting Super Collider (SSC) are discussed, referring to other coming colliders. In addition, the present status of the SSC project and detector proposals for the experiments are described. (author)

  9. Primary Lung Signet Ring Cell Carcinoma Presenting as a Cavitary Pancoast Tumor in a 32-Year-Old Man.

    Science.gov (United States)

    Corvini, Michael; Koorji, Alysha; Sgroe, Erica; Nguyen, Uyen

    2018-06-01

    Signet ring cell carcinoma, a subtype of adenocarcinoma, is a rare cause of primary lung cancer. The authors report a case of primary lung signet ring cell carcinoma presenting as a cavitary Pancoast tumor in a 32-year-old male smoker. Beyond the rarity of primary lung signet ring cell carcinoma itself, the youth of the patient, his smoking status, the presence of cavitation, and the location of the tumor in the superior sulcus make it especially atypical.

  10. Influence of human papillomavirus on the clinical presentation of oropharyngeal carcinoma in the United States.

    Science.gov (United States)

    Stenmark, Matthew H; Shumway, Dean; Guo, Cui; Vainshtein, Jeffrey; Mierzwa, Michelle; Jagsi, Reshma; Griggs, Jennifer J; Banerjee, Mousumi

    2017-10-01

    Much of what is known about the significance of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma is derived from single-institution retrospective studies, post hoc analyses of tissue specimens from clinical trials, and tissue bank studies with a small sample size. The objective of this study is to investigate the impact of HPV on the frequency and clinical presentation of oropharyngeal carcinoma in a large, national sample with information from patients who underwent HPV testing. Retrospective, cross-sectional study. We identified a comprehensive national sample of 8,359 patients with oropharyngeal carcinoma and known HPV status diagnosed between 2010 and 2011 within the National Cancer Database. Multivariable logistic regression was used to assess correlates of patient and tumor characteristics on HPV status. Among patients with oropharyngeal carcinoma, the frequency of HPV-related squamous cell carcinoma in the United States was 65.4%. HPV-related oropharyngeal carcinoma was associated with younger age, male sex, and white race (P presentation (P clinical profile, supporting efforts to re-evaluate the staging and treatment paradigm for HPV-associated oropharyngeal cancer. 4. Laryngoscope, 127:2270-2278, 2017. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  11. Present status of foreign reprocessing technology

    International Nuclear Information System (INIS)

    Otagaki, Takao; Ishikawa, Yasusi; Mori, Jyunichi

    2000-03-01

    In considering extensively and evaluating advanced nuclear fuel recycle technologies then selecting credible one among those technology options and establishing practicable plan of future fast reactor fuel recycle technology, it is important to investigate foreign reprocessing information extensively and minutely as much as possible then to know trends of reprocessing technology development in the world and present technology level of each country. This report is intending to present information of the status and the technology of operating, constructing and closed foreign reprocessing facilities in the world, including, mixed oxide (MOX) fuel reprocessing technology. The conceptual study of 'Foreign Reprocessing Technology Database' was also performed in order to add or revise the information easily. The eight countries, France, The U.K., Russia, The U.S., Germany, Belgium, India and China, were studied regarding outline of the facilities, operation status, future plan, technical information of process flow sheet, primary components, maintenance system etc, construction and operating costs, accidents or troubles, decommissioning status. (author)

  12. Metastatic Renal Cell Carcinoma to Jejunum: An Unusual Case Presentation

    Directory of Open Access Journals (Sweden)

    Igor Medic

    2017-07-01

    Full Text Available The small intestine is a very uncommon and peculiar site for metastasis from renal cell carcinoma (RCC. We present a clinical presentation of insidious and unusual development of a jejunal metastasis while having stable disease in a remainder of metastatic sites, in a patient undergoing immunotherapy with nivolumab. Due to the extreme rarity of metastatic renal cell carcinoma to the lumen of the small bowel, it is easy to overlook and misdiagnose symptoms of this pathologic entity, particularly when the remainder of metastatic disease responds well to ongoing therapy.

  13. Neutrino oscillations: present status and outlook

    International Nuclear Information System (INIS)

    Schwetz, T.

    2005-01-01

    In this talk the present status of neutrino oscillations is reviewed, based on a global analysis of world neutrino oscillation data from solar, atmospheric, reactor, and accelerator neutrino experiments. Furthermore, I discuss the expected improvements in the determination of neutrino parameters by future oscillation experiments within a timescale of 10 years. (author)

  14. Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism

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    Habib G. Zalzal

    2018-01-01

    Full Text Available Background. Undifferentiated anaplastic carcinoma rarely develops from chronic hyperthyroidism. Although acute hyperthyroidism can develop prior to anaplastic transformation, chronic hyperthyroidism was thought to be a protective measure against thyroid malignancy. Methods. A 79-year-old female presented acutely to the hospital with dyspnea. She had been taking methimazole for chronic hyperthyroidism due to toxic thyroid nodules, previously biopsied as benign. Upon admission, imaging showed tracheal compression, requiring a total thyroidectomy with tracheostomy for airway management. Results. Pathology demonstrated undifferentiated anaplastic thyroid carcinoma. The patient passed away shortly after hospital discharge. Despite treatment with methimazole for many years, abrupt enlargement of her toxic multinodular goiter was consistent with malignant transformation. Chronic hyperthyroidism and toxic nodules are rarely associated with thyroid malignancy, with only one previous report documenting association with anaplastic thyroid carcinoma. Conclusion. Progressive thyroid enlargement and acute worsening of previously controlled hyperthyroidism should promote concern for disease regardless of baseline thyroid function.

  15. Prallethrin Poisoning Presenting as Status Epilepticus

    Directory of Open Access Journals (Sweden)

    D Vijayaraju

    2014-02-01

    Full Text Available Mosquito repellents contain pyrethroid derivatives, as the active ingredient. Data regarding human toxicity following oral intake is limited. This is a case report of an individual who presented with neurotoxicity following oral ingestion of prallethrin (2.4% w/w of a higher concentration present in formulations commercially available than previously. A 22 year old male presented to the emergency Room (ER in status epilepticus. He was managed in the Intensive Care Unit (ICU. No cause for his status could be determined after all laboratory investigations. A review of history with the patient revealed that he had ingested a bottle of liquid mosquito repellent (45 ml. The patient has had no further symptoms on follow up and has been off anti epileptics. Pyrethroid containing mosquito repellents act on neuronal sodium channels causing hyperexcitiability. With no known specific antidotes, symptomatic treatment is the main stay of management.

  16. Metastatic Carcinoma of Unknown Primary Presenting as Jugular Venous Thrombosis

    Directory of Open Access Journals (Sweden)

    Prince Cheriyan Modayil

    2009-01-01

    Full Text Available Jugular venous thrombosis is unusual and is associated with central venous catheterisation, intravenous drug abuse and head and neck sepsis. It is rarely associated with malignancy. We report a case of metastatic carcinoma of unknown primary in a forty year old female which presented with jugular venous thrombosis. The discussion includes investigation and treatment options for this condition.

  17. Chronic hepatitis C presenting with a diagnosis of hepatocellular carcinoma

    DEFF Research Database (Denmark)

    Hallager, Sofie; Weis, Nina

    2014-01-01

    Chronic hepatitis C (CHC) affects around 16,000 individuals in Denmark of whom about 50% are diagnosed. In the presence of CHC and cirrhosis the annual risk of hepatocellular carcinoma (HCC) is 1-5%. We report on two patients who presented with disseminated HCC at the time of CHC diagnosis...

  18. Pilomatrix carcinoma presenting as an extra axial mass: clinicopathological features

    Directory of Open Access Journals (Sweden)

    Gibbons David

    2008-11-01

    Full Text Available Abstract Pilomatrix carcinoma is the rare malignant counterpart of pilomatrixoma, a skin adnexal tumour originating from hair matrix cells. Pilomatrix carcinoma can arise as a solitary lesion de novo, or through transformation of a pilomatrixoma. Pilomatrixoma was first described erroneously as being of sebaceous gland origin but was later discovered to be derived from hair matrix cells. They are rare, slow growing tumours of the skin found in the lower dermis and subcutaneous fat and are predominantly found in the neck and the scalp. While known to be locally aggressive, no malignant form was thought to exist until it was described relatively recently. Since then, approximately ninety cases of pilomatrix carcinoma have been reported. We report the case of a 41 year old mentally retarded male who had a longstanding lesion in the left neck for approximately fifteen years previously diagnosed as a pilomatrixoma. He presented with severe headache, falls and visual disturbance and a biopsy showed pilomatrix carcinoma of the occipital region which, on computed tomography ( CT invaded the occipital bone, the cerebellum and the left temporal lobe. At his initial presentation he had a craniotomy and subtotal excision of the lesion but received no adjuvant therapy. After an early intracranial recurrence he had further debulking and adjuvant external beam radiotherapy. He has had no further intracranial recurrence after three and a half years of follow-up. Here we present the pathological features of this uncommon tumour.

  19. Pilomatrix carcinoma presenting as an extra axial mass: clinicopathological features.

    LENUS (Irish Health Repository)

    Aherne, Noel J

    2008-01-01

    Pilomatrix carcinoma is the rare malignant counterpart of pilomatrixoma, a skin adnexal tumour originating from hair matrix cells. Pilomatrix carcinoma can arise as a solitary lesion de novo, or through transformation of a pilomatrixoma. Pilomatrixoma was first described erroneously as being of sebaceous gland origin but was later discovered to be derived from hair matrix cells. They are rare, slow growing tumours of the skin found in the lower dermis and subcutaneous fat and are predominantly found in the neck and the scalp. While known to be locally aggressive, no malignant form was thought to exist until it was described relatively recently. Since then, approximately ninety cases of pilomatrix carcinoma have been reported.We report the case of a 41 year old mentally retarded male who had a longstanding lesion in the left neck for approximately fifteen years previously diagnosed as a pilomatrixoma. He presented with severe headache, falls and visual disturbance and a biopsy showed pilomatrix carcinoma of the occipital region which, on computed tomography ( CT ) invaded the occipital bone, the cerebellum and the left temporal lobe. At his initial presentation he had a craniotomy and subtotal excision of the lesion but received no adjuvant therapy. After an early intracranial recurrence he had further debulking and adjuvant external beam radiotherapy. He has had no further intracranial recurrence after three and a half years of follow-up. Here we present the pathological features of this uncommon tumour.

  20. Present status of HTGR research and development

    International Nuclear Information System (INIS)

    1991-04-01

    The HTTR is a test reactor with thermal output of 30MW and outlet coolant temperature of 950degC, employing the pin-in-block type fuel, and has the capability to demonstrate nuclear process heat utilization using an intermediate heat exchanger. The official construction of the HTTR facility is scheduled to start on March 15, 1991. This publication summarizes the present status of R and D of high temperature gas cooled reactors in JAERI. (J.P.N.)

  1. Immunological status of patients with uterine ceroix carcinoma

    International Nuclear Information System (INIS)

    Il'in, I.V.; Dekster, L.I.; Letskij, V.B.

    1979-01-01

    Comparative data on the immunological status of 60 patients with uterine cervix carcinoma 27 of whom were exposed to combined radiotherapy are given. The evaluation of the immunological parameters makes it possible to note a marked affection of the T system by radiant energy. Taking into consideration a significant immunodepressive effect of irradiation it is advisable that immunotherapy by included into the therapeutic regimen

  2. The INCA project: present status and outlook

    International Nuclear Information System (INIS)

    Aleksandrov, K.V.; Ammosov, V.V.; Chechin, V.A.; Chubenko, A.P.; Erlykin, A.D.; Ladygin, E.A.; Merzon, G.I.; Mukhamedshin, R.A.; Murashov, V.N.; Pavlyuchenko, V.P.; Ryabov, V.A.; Ryazhskaya, O.G.; Saito, T.; Sobolevskii, N.M.; Shchepetov, A.L.; Starkov, N.I.; Trostin, I.S.; Tsarev, V.A.; Wolfendale, A.; Zatsepin, G.T.; Zhdanov, G.B.; Zhukov, A.P.

    2002-01-01

    Scientific objectives, foundations, status, and outlook of the INCA Project are presented. Fundamentally new technique based on the ionization-neutron calorimeter (INCA) and designed to study local nearby sources of high-energy cosmic rays by direct measuring the spectrum and composition of the nuclear component in the 'knee' region and the spectrum of primary electrons in the energy range 0.1-10 TeV with the proton-background suppression factor up to 10 7 is discussed. Experimental data on exposition of the INCA prototypes to electron, pion, and proton beams at various energies and corresponding simulation results are presented. Prospects are considered

  3. Present status of mirror stability theory

    International Nuclear Information System (INIS)

    Baldwin, D.E.; Berk, H.L.; Byers, J.A.

    1976-01-01

    A status report of microinstability as it applies to 2XIIB and MX theory for mirror machines is presented. It is shown that quasilinear computations reproduce many of the parameters observed in the 2XIIB experiment. In regard to large mirror machines, there are presented detailed calculations of the linear theory of the drift cyclotron loss-cone mode, with inhomogeneous geometry and nonlinear diffusive effects. Further, the stability of a mirror machine to the Alfven ion-cyclotron instability is assessed, and the Baldwin-Callen diffusion is estimated for a spatially varying plasma

  4. Squamous cell carcinoma presenting as an endodontic-periodontic lesion.

    Science.gov (United States)

    Levi, Paul A; Kim, David M; Harsfield, Scott L; Jacobson, Erica R

    2005-10-01

    Regardless of advances in diagnosis and treatment during the past 40 years, the overall 5-year survival rates for oral and oropharyngeal squamous cancers have only slightly improved and remain around 50%. Thus, the early diagnosis and treatment of carcinoma by health care providers are essential in achieving a good prognosis. We report a case of invasive squamous cell carcinoma that presented as a benign endodontic-periodontic lesion with a 7-mm periodontal pocket on tooth #15 in a 40-year-old, non-smoking woman. The subsequent management of the case is also discussed. The study was conducted in accordance with the Helsinki Declaration of 1975, as revised in 2000. Our patient was seen for a comprehensive periodontal examination including a periodontal charting, occlusal analysis, study casts, electronic pulp test for tooth #15, and complete mouth periapical radiographs. As there was a periapical radiolucency, an endodontic consultation was obtained. A periodontal flap surgical procedure was performed on teeth #13 to #15, and as there was bone erosion into the maxillary sinus, a biopsy of the soft tissue was submitted to the local hospital for histological analysis. The biopsied lesion was diagnosed as invasive, moderately differentiated squamous cell carcinoma with focal spindle and clear cell differentiation (grade II to III of IV). Bone invasion was also identified. The treatment of the carcinoma involved a hemimaxillectomy with the removal of the maxillary left posterior teeth. The patient remained free of tumor for 5 years after the initial presentation. Patient education and periodic oral cancer examinations by dental professionals are necessary to reduce diagnostic delay and improve prognosis. This case report emphasizes the important role of dental professionals, especially periodontists and endodontists, of being aware that squamous cell carcinoma may manifest itself clinically and/or radiographically as a common periodontal or endodontic lesion.

  5. Invasive lobular carcinoma: a rare presentation in the male breast.

    Science.gov (United States)

    Melo Abreu, Elisa; Pereira, Pedro; Marques, José Carlos; Esteves, Gonçalo

    2016-05-05

    Breast cancer in men is uncommon, accounting for cancers. Even though lobular structures are quite infrequent in the male breast, rare cases of invasive lobular breast carcinoma have been described, representing 1-2% of all breast cancers in men. Risk factors include undescended testes, congenital inguinal hernia, orchiectomy, orchitis, testicular injury, infertility and Klinefelter's syndrome, previous thoracic radiotherapy, alterations of the oestrogen-testosterone ratio and familial history (BRCA 2 and 1). The authors present a case of a 52-year-old man with no relevant predisposing factors to breast cancer, who presented with a painless, firm nodule, fixed to the nipple on the left breast, associated with nipple retraction and ulceration, and fully characterised by mammogram and ultrasound. Histopathological and immunohistochemical analysis revealed the diagnosis of invasive lobular breast carcinoma and the patient underwent left radical mastectomy, followed by adjuvant chemotherapy, radiotherapy and hormonotherapy. A brief review of the literature is presented. 2016 BMJ Publishing Group Ltd.

  6. Present status of TCA/BR Tokamak

    International Nuclear Information System (INIS)

    Nascimento, I.C.; Galvao, R.M.O.; Tuszel, A.G.

    1997-01-01

    The TCA tokamak is being partially reconstructed and reassembled in the Plasma Laboratory of The University of Sao Paulo, and afterwards it will be named TCA/BR. The first discharges are expected by June/July of next year. The main scientific objectives envisaged for the machine are: Alfven wave heating and current drive, confinement improvement, disruptions and turbulence. In this paper we also describe: (i) the present status of the project; (ii) the diagnostic system; (iii) the control and data acquisition system; (iv) the RF system for the excitation of Alfven waves, that are being developed, and also the results of predictive transport simulations of its performance. (author)

  7. A Unique Presentation of an Undiagnosed Renal Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Georgios Kravvas

    2014-01-01

    Full Text Available We describe a 58-year-old lady who presented initially to her general practitioner with a palpable warty urethral nodule. She was subsequently referred to the urology department for further investigations. She underwent flexible cystoscopy and imaging, followed by rigid cystoscopy and excision of the nodule. Histological analysis was consistent with renal cell carcinoma (RCC. CT imaging confirmed the presence of an invading metastatic left renal cell carcinoma with bilateral metastatic deposits to the lungs and adrenal glands. The patient was enlisted on the Panther Trial and received a course of Pazopanib before undergoing radical nephrectomy. Two years later she is still alive with metastases remaining reduced in size and numbers. During this study we have performed a literature review of similar cases with this unusual presentation of RCC.

  8. Parathyroid carcinoma: an unusual presentation of a rare neoplasm

    Directory of Open Access Journals (Sweden)

    Shruti, Sharma

    2017-12-01

    Full Text Available Parathyroid carcinoma is an extremely rare malignant endocrine neoplasm that is very challenging in its diagnosis as well as its treatment. Clinically the disease is detected earlier in patients who present with hyperparathyroidism with signs of profound hypercalcemia. Differentiation between benign and malignant disease of the parathyroid is challenging both for the clinician and for the pathologist. Complete surgical resection at the time of first operation offers the best chance of cure. Even after radical excision which is the standard management, local recurrence and metastases are frequent. The disease usually has a slow indolent course and most patients suffer from complications of hypercalcemia rather than tumor invasion or metastasis.We report a case of a 31-year-old woman who presented with renal colic. Various hematological, biochemical and radiological investigations were performed and a slightly enlarged right parathyroid was found. A clinical diagnosis of parathyroid adenoma was made and a right parathyroidectomy was done. Intraoperatively the surgeon had no suspicion of malignancy but microscopically the lesion was malignant and a final diagnosis of parathyroid carcinoma was rendered based on the criteria of invasion. Since there is no gold standard, a multidisciplinary approach, including the entire clinical, biochemical, radiological and pathological profile of the disease aids in an accurate diagnosis. Here we are reporting a case of a functional parathyroid carcinoma presenting in a relatively young patient with all the biochemical and radiological investigations and findings pointing towards a benign parathyroid disease.

  9. Renal Cell Carcinoma Metastatic to Thyroid Gland, Presenting Like Anaplastic Carcinoma of Thyroid

    Directory of Open Access Journals (Sweden)

    Khalid Riaz

    2013-01-01

    Full Text Available Background. Renal cell carcinoma (RCC has unpredictable and diverse behavior. The classic triad of hematuria, loin pain, and abdominal mass is uncommon. At time of diagnosis, 25%–30% of patients are found to have metastases. Bones, lungs, liver, and brain are the frequent sites of metastases. RCC with metastasis to the head and neck region and thyroid gland is the rarest manifestation and anaplastic carcinoma behaving metastatic thyroid mass is an extremely rare presentation of RCC. Case Presentation. A 56-year-old Saudi man with past history of right radical nephrectomy 5 years back presented with 3 months history of rapid increasing neck mass with dysphagia, presenting like anaplastic thyroid carcinoma. Tru-cut biopsy turned out to be metastatic renal cell carcinoma. Patient was treated with radiation therapy 30 Gy in 10 fractions to mass. Patient died 4 months after the discovery of anaplastic thyroid looking metastasis. Conclusion. Rapidly progressing thyroid metastases secondary to RCC are rare and found often unresectable which are not amenable to surgery. Palliative radiotherapy can be considered for such patients.

  10. Present status of the Penrose inequality

    Energy Technology Data Exchange (ETDEWEB)

    Mars, Marc [Facultad de Ciencias, Universidad de Salamanca, Plaza de la Merced s/n, 37008 Salamanca (Spain)

    2009-10-07

    The Penrose inequality gives a lower bound for the total mass of a spacetime in terms of the area of suitable surfaces that represent black holes. Its validity is supported by the cosmic censorship conjecture, and therefore its proof (or disproof) is an important problem in relation with gravitational collapse. The Penrose inequality is a very challenging problem in mathematical relativity and it has received continuous attention since its formulation by Penrose in the early seventies. Important breakthroughs have been made in the last decade or so, with the complete resolution of the so-called Riemannian Penrose inequality and a very interesting proposal to address the general case by Bray and Khuri. In this review, the most important results on this field will be discussed and the main ideas behind their proofs will be summarized, with the aim of presenting what is the status of our present knowledge in this topic. (topical review)

  11. Fibrolamellar Hepatocellular Carcinoma Presenting as Obstructive Jaundice: Uncommon Presentation of a Rare Entity

    International Nuclear Information System (INIS)

    Arora, Richa

    2015-01-01

    Fibrolamellar hepatocellular carcinoma is a rare primary malignant liver tumor, significantly different from generic hepatocellular carcinoma with distinct demographics, risk factors, imaging features, histopathology and prognosis. Unlike conventional hepatocellular carcinoma, it presents in young individuals with no preexisting hepatitis or cirrhosis and does not cause elevation of serum alpha feto proteins in most cases. This paper presents a case report of this rare tumor in a young female with an unusual clinical manifestation of obstructive jaundice (which has not been reported so far) along with a review of its imaging and pathological features, with treatment options. Fibrolamellar HCC is a rare variant of classic HCC with different epidemiology, risk factors, clinical manifestations, radiological, pathological and prognostic features. Therefore, it is important to be familiar with the entity for its early diagnosis and management

  12. Breast Cancer with Synchronous Renal Cell Carcinoma: A Rare Presentation.

    Science.gov (United States)

    Arjunan, Ravi; Kumar, Durgesh; Kumar, K V Veerendra; Premlatha, C S

    2016-10-01

    Primary cancer arising from multiple organs is a well known fact. Synchronous tumours have been most commonly associated with kidney cancer. Bladder, prostate, colorectal and lung cancer are the most common synchronous primaries with Renal Cell Carcinoma (RCC) identified till date. We found metachronous tumours of breast with RCC in literature search which included both metastatic tumours as well second primaries. Overall, 25 cases of metastatic breast tumours and eight cases of second primary in previously treated RCC have been reported in the literature. Here, we are reporting a case of synchronous presentation of carcinoma breast with RCC which is very rare because most of the multiple malignancies reported in the literature are metastatic tumours or metachronous breast malignancy with RCC.

  13. [Immunotherapy for renal cell carcinoma - current status].

    Science.gov (United States)

    Grimm, Marc-Oliver; Foller, Susan

    2018-04-01

    Systemic treatment of metastatic renal cell carcinoma (mRCC) has substantially changed during the last 2 years due to approval of the immune-checkpoint inhibitor Nivolumab (Opdivo ® ) and new multikinase inhibitors (Cabozantinib, Lenvatinib, Tivozanib). The german kidney tumor guideline strongly recommends Nivolumab and Cabozantinib as 2nd line treatments after prior VEGF targeted therapy. CheckMate 025, the prospective randomized trial which led to approval of Nivolumab demonstrated improved overall survival (26 month vs. 19.7 month; hazard ratio 0.73; p = 0.0006) and response rate (26 % vs. 5 %) as well as a favorable toxicity profile compared with Everolimus. Currently, numerous combinations with PD-1/PD-L1 inhibitors are compared to Sunitinib as first line treatment of mRCC. Out of these CheckMate 214, a randomized phase-3 trial is the first to demonstrate a significant higher objective response rate (42 % vs. 27 %, p < 0.0001) and overall survival (Sunitinib 26.0 month, median for Nivo + Ipi has been not yet reached (28.2 - NR); Hazard ratio 0.63) for the combination of Nivolumab and the CTLA-4 antibody Ipilimumab in IMDC intermediate and high risk patients. Furthermore, CheckMate 214 shows better side effect profile and quality of life in patients receiving Nivolumab and Ipilimumab compared with Sunitinib. However, a considerable increase of immune related adverse events is associated with the immune combination therapy. Another randomized trial demonstrates improved progression-free survival for the combination of the PD-L1 inhibitor Atezolizumab and the VEGF antibody Bevacizumab in patients with PD-L1 positive tumors; this was found in all IMDC risk groups. Further phase-3 trials with "new" VEGFR-TKIs (Axitinib, Cabozantinib, Lenvatinib) and PD-1/PD-L1 inhibitor combinations are ongoing.In conclusion, the PD-1 immune checkpoint inhibitor Nivolumab will remain a standard treatment for patients with metastatic renal cell carcinoma

  14. Present status of the SRRC Project

    International Nuclear Information System (INIS)

    Chang, C.; Cheng, K.C.; Liu, Y.C.; Tseng, P.K.

    1985-01-01

    Upon the recommendation of the overseas Chinese scholars and the feasibility study group organized by the National Science Council, the government approved the establishment of the Synchrotron Radiation Research Center (SRRC) on July 9, 1983. The main goal of the SRRC project is to construct and operate an up-to-date 1 GeV synchrotron radiation source, with three beam lines for general experiments, in five to six years; to provide local scientists and returned scientists from abroad a facility to carry out frontier researches in both basic and applied science; and to elevate the technological capabilities of the related industries, universities, and research institutes through the construction of the machine. The background and present status of the project are discussed

  15. The present status of artificial rain making

    International Nuclear Information System (INIS)

    Choudhury, A.M.

    1987-11-01

    In this paper a review has been made of the present status of artificial rainmaking. The history of artificial rainmaking goes back to 1946 when Vincent Schaefer of the USA discovered the general principles. During the last 40 years cloud seeding activities have stirred the imagination of scientists all over the world. If this could be carried out in an operational manner, mankind could have solved the problems of drought which threaten many parts of the globe with famine. However, though a lot of progress has been made in cloud physics, an operational rainmaking programme is yet far from reality. In some cases seeding increases the rainfall whereas in other cases a decrease in rainfall has been noticed. It would be necessary to approach the subject more thoroughly and systematically and while making experiments on rainmaking a proper experimental design should be carried out so that the results of such experiments could be evaluated scientifically. (author). 11 refs

  16. The present status of software engineering

    CERN Document Server

    Pressman, Roger S

    1991-01-01

    In this seminar, we will discuss the present status and future directions of software engeneering and CASE. Key topics to be discussed include: new paradigms for software engineering; software metrics; process assessment; the current state of analysis and design methods; reusability and re-engineering; formal methods. Among the questions to be answered are: How will software engineering change as the 1990s progress? What are the "technology drivers"? What will analysis, design, coding, testing, quality assurance and software management look like in the year 2000? How will CASE tools evolve in the 1990s and will they be as "integrated" as many people believe? How can you position your Organization to accommodate the coming changes?

  17. Bone metastases as initial presentation of hepatocellular carcinoma.

    Science.gov (United States)

    Monteserin, Luzdivina; Mesa, Alicia; Fernandez-Garcia, Maria Soledad; Gadanon-Garcia, Arantza; Rodriguez, Manuel; Varela, María

    2017-10-18

    Extra-hepatic spread is present in 5% to 15% of patients with hepatocellular carcinoma (HCC) at the time of diagnosis. The most frequent sites are lung and regional lymph nodes. Here, we report 3 cases of unsuspected HCC with symptoms due to bone lesions as initial presentation. Morphological characteristics and immunohistochemistry from the examined bone were the key data for diagnosis. None of the patients had an already known chronic liver disease. Differential diagnoses with HCC upon ectopic liver disease or hepatoid adenocarcinoma were shown. Therapy with the orally active multikinase inhibitor sorafenib plus symptomatic treatment was indicated.

  18. CMS: Present status, limitations, and upgrade plans

    International Nuclear Information System (INIS)

    Cheung, H.W.K.

    2011-01-01

    An overview of the CMS upgrade plans will be presented. A brief status of the CMS detector will be given, covering some of the issues we have so far experienced. This will be followed by an overview of the various CMS upgrades planned, covering the main motivations for them, and the various R and D efforts for the possibilities under study. The CMS detector has been working extremely well since the start of data-taking at the LHC as is evidenced by the numerous excellent results published by CMS and presented at this workshop and recent conferences. Less well documented are the various issues that have been encountered with the detector. In the spirit of this workshop I will cover some of these issues with particular emphasis on problems that motivate some of the upgrades to the CMS detector for this decade of data-taking. Though the CMS detector has been working extremely well and expectations are great for making the most of the LHC luminosity, there have been a number of issues encountered so far. Some of these have been described and while none currently presents a problem for physics performance, some of them are expected to become more problematic, especially at the highest Phase 1 luminosities for which the majority of the integrated luminosity will be collected. These motivate upgrades for various parts of the CMS detector so that the current excellent physics performance can be maintained or even surpassed in the realm of the highest Phase 1 luminosities.

  19. Esophageal Squamous Cell Carcinoma Presenting with Streptococcus intermedius Cerebral Abscess

    Directory of Open Access Journals (Sweden)

    Rabih Nayfe

    2017-01-01

    Full Text Available Background. Cerebral abscess is caused by inoculation of an organism into the brain parenchyma from a site distant from the central nervous system. Streptococcus intermedius (S. intermedius is a commensal organism that is normally present in the aerodigestive tract and was reported to be the cause of brain abscesses after esophageal dilatation or upper endoscopy. Case Presentation. We report the case of a 53-year-old female who presented with hematemesis and melena followed by left-sided weakness. Initially, her hemiplegia was found to be secondary to a right thalamic brain abscess caused by S. intermedius. Investigations led to the diagnosis of a mid-esophageal squamous cell carcinoma. We hypothesize that the cause of the abscess with this bacterium that naturally resides in the digestive tract and oral cavity is secondary to hematogenous spread from breach in the mucosal integrity from ulceration due to the cancer. Conclusion. To our knowledge, our case is the first in the literature to describe a brain abscess caused by S. intermedius in association with a previously undiagnosed esophageal squamous cell carcinoma without any prior esophageal intervention.

  20. Present status and problems of marine reactor

    International Nuclear Information System (INIS)

    1987-01-01

    The activities of the Research Committee on Marine Reactors are summarized, and the present status of marine reactors on the world is reviewed. The characteristics of marine reactors are discussed, and the prospect and problems of the research and development of an advanced marine reactor in Japan are reported. This Committee was established in fiscal year 1983, when the 'Mutsu' project was going to be on the right track, and the project of developing an advanced marine reactor was advanced. During four years since then, it has carried out the investigation and exchanged opinion about the activities and results of the research in foreign countries and Japan and the problems peculiar to marine reactors, that is, making small size and light weight reactors, the rolling and pitching, vibration and impact of ship hulls, the competitive power against conventional ships and so on. The idea of utilizing atomic energy for ship propulsion preceded that of electricity generation, and it was materialized in 1955 by the submarine 'Nautilus'. Now more than 300 nuclear war ships have been commissioned. Also nuclear merchant ships have been built, but the research and development were interrupted because of their economical efficiency. (Kako, I.)

  1. Present status of space nuclear reactor

    International Nuclear Information System (INIS)

    Kaneko, Yoshihiko

    1996-01-01

    USA and former USSR led space development, and had the experience of launching nuclear reactor satellites. In USA, the research and development of space nuclear reactor were advanced mainly by NASA, and in 1965, the nuclear reactor for power source ''SNAP-10A'' was launched and put on the orbit around the earth. Thereafter, the reactor was started up, and the verifying test at 500 We was successfully carried out. Also for developing the reactor for thermal propulsion, NERVA/ROVER project was done till 1973, and the technological basis was established. The space Exploration Initiative for sending mankind to other solar system planets than the earth is the essential point of the future projects. In former USSR, the ground experiment of the reactor for 800 We power source ''Romashka'', the development of the reactor for 10 kWe power source ''Topaz-1 and 2'', the flight of the artificial satellites, Cosmos 954 and Cosmos 1900, on which nuclear reactors were mounted, and the operation of 33 ocean-monitoring satellites ''RORSAT'' using small fast reactors were carried out. The mission of space development and the nuclear reactors as power source, the engineering of space nuclear reactors, the present status and the trend of space nuclear reactor development, and the investigation by the UN working group on the safety problem of space nuclear reactors are described. (K.I.)

  2. Present Status of Odour Management in Malaysia

    International Nuclear Information System (INIS)

    Mohd Nahar Othman

    2014-01-01

    The nuisance odour complaints received by the Department of Environment of Malaysia in 2006 are about 1082 cases. The trend shows that odor problems have become more and more acute every year. The sources of odor complaints come from many types of industries such as animal raring industry, chemical industries, rubber processing industries, municipal solid wastes (MSW), sewage treatment plants, palm oil industries, petroleum industries and etc. There are no specific odour control technology to solve the odour problem in the country. Some of the odour problems became more acute because the sources odour are located in places which are in the living area because lack of space. At the same time, there is no regulation concerning the specific odor parameter stated in the Environment Quality Acts 1974. The Department of Environment had drafted a regulation in order to monitor this problem, relating to the nuisance coming from these industries but until now the regulation still pending. The aim of this paper is to describe the present status of odour problem in Malaysia and the public exception of this problem. (author)

  3. Present status of fusion reactor materials, 4

    International Nuclear Information System (INIS)

    Nagasaki, Ryukichi; Shiraishi, Kensuke; Watanabe, Hitoshi; Murakami, Yoshio; Takamura, Saburo

    1982-01-01

    Recently, the design of fusion reactors such as Intor has been carried out, and various properties that fusion reactor materials should have been clarified. In the Japan Atomic Energy Research Institute, the research and development of materials aiming at a tokamak type experimental fusion reactor are in progress. In this paper, the problems, the present status of research and development and the future plan about the surface materials and structural materials for the first wall, blanket materials and magnet materials are explained. The construction of the critical plasma testing facility JT-60 developed by JAERI has progressed smoothly, and the operation is expected in 1985. The research changes from that of plasma physics to that of reactor technology. In tokamak type fusion reactors, high temperature D-T plasma is contained with strong magnetic field in vacuum vessels, and the neutrons produced by nuclear reaction, charged particles diffusing from plasma and neutral particles by charge exchange strike the first wall. The PCA by improving 316 stainless steel is used as the structural material, and TiC coating techniques are developed. As the blanket material, Li 2 O is studied, and superconducting magnets are developed. (Koko, I.)

  4. Clinical presentation of nasopharyngeal carcinoma in Sarawak Malaysia.

    Science.gov (United States)

    Tiong, T S; Selva, K S

    2005-12-01

    Nasopharyngeal carcinoma (NPC) is a common cancer in Malaysia. The clinical presentation in Sarawak has not been well documented. A retrospective review of 213 selected NPC cases was undertaken on the clinical records in Sarawak General Hospital, Sarawak, from June 1999 to June 2003. There were 116 patients in Kuching and 97 in Serian. There were twice as many males as females. The youngest patient was 16 and the oldest 88 years old with a mean age of 51 years. The four most common symptoms in order of frequencies were cervical lymphadenopathy, epistaxis, hearing loss and diplopia. 80.8% of the patients presented with cervical lymphadenopathy and about 85% of the patients presented in the advanced stages. Very small percentages of the patients were found to have single presenting symptoms of epistaxis (2.4%) and hearing loss (0.5%).

  5. Present status of radiation utilization in Thailand

    International Nuclear Information System (INIS)

    Chongkum, S.

    1994-01-01

    Present development of radiation utilization in Thailand covers two main areas, i.e. (1) production and utilization of radioisotopes and (2) radiation processing and technology. Radioisotope production from 2 megawatts Thai Research Reactor (TRR1/M1) is being studied, directed toward expanding the varieties of radioisotopes, improvement of quality, and technological development on quantity producing to meet the total national needs. However a large amount of radioisotopes is also imported mainly for industrial and medical applications. Radioisotopes and radiations are utilized in nuclear medicine for diagnosis and therapy from 30 hospitals and institutions. X-ray photographing, X-ray computer tomography and others are typical use for medical examination purposes, while Co-60 gamma rays and electron beam are in used for curing. Since 1972, Thailand has been participated to the IAEA/RCA Industrial Project, through the liaison of the Office of Atomic Energy for Peace (OAEP), and increases the awareness of industry to the economic benefits through the uses of nuclear technology. More than 60 companies are using radioisotopes for gauging, examination purposes and production controls, while these radioisotopes are mostly imported. Nuclear techniques in agriculture are addressed concerns with optimizing fertilizer application, determination soil-water-nitrogen fixation relationships, improving animal health and reproduction, measurement of toxic residues, appropriated food preservation techniques and breeding plant for better yield and disease resistance. The eradication of fruit flies by Sterile Insect Technique (SIT) with gamma rays has been successfully applied in northern and middle part of Thailand. The progress and present status of radiation utilization and processing in Thailand will be introduced. (author)

  6. Endometriosis presenting as carcinoma colon in a perimenopausal woman

    Directory of Open Access Journals (Sweden)

    Tanuja Muthyala

    2015-01-01

    Full Text Available Endometriosis is a common benign disease of reproductive age women, and can involve the intestinal tract. Inconsistent clinical presentation, similar features on radiological imaging and colonoscopy with other inflammatory and malignant lesions of the bowel makes the preoperative diagnosis of bowel endometriosis difficult. We present a case of a 42-year-old perimenopausal female clinically presented, investigated and managed in the lines of carcinoma of sigmoid colon. She underwent terminal ileac resection with end to end anastomoses, Hartmann′s procedure and total hysterectomy with bilateral salpingoophorectomy. The histopathological report revealed endometriosis of small intestine, large intestine, mesentery, right ovary and adenomyoma of uterus. Thus, bowel endometriosis should also be considered as differential diagnosis in reproductive age women with gastrointestinal symptoms or intestinal mass of uncertain diagnosis.

  7. Present status of iodine research at IPSN

    Energy Technology Data Exchange (ETDEWEB)

    Bardelay, J [IPSN/DPEA/SEAC (France)

    1996-12-01

    Since several years, IPSN has conducted an effort in order to evaluate the release of radioactive iodine in case of hypothetical severe accident in a realistic manner. This source-term evaluation is performed with IODE code which is a module of the EXCADRE system of codes. This code is validated against: -analytical experiments: in these experiments, IPSN studies radiolytic effects and chemical processes in the sump, organic formation, mass transfer, effect of spray (CARAIDAS experiment), - the CAIMAN semi global experiment; this experiment will allow to study the phenomena linked to iodine behavior under representative containment geometry in the presence of painted surfaces and global irradiation, - the PHEBUS FP program. The paper consists to describe succinctly the current status of IODE and the various experiments for its validation. In case of hypothetical severe accident iodine can induce important perturbations of human organism. The effects are principally radiological, in particular on the thyroid. At short term, radioactive iodine is the most important contributor for the sanitary risk. It represents 55% of effective dose and 92% of thyroid dose at 10 km in case of controlled rejects with current assumptions. This is the reason why it must be actively studied. In France, the safety evaluations are performed with mechanistic codes or lumped parameter codes like EXCADRE which contains a module devoted to iodine studies: IODINE. The objective of the French experimental program on iodine is to understand and quantify important phenomena in order to put kinetic parameters in IODE module. The experiments can be classified in analytical experiments, the semi-global experiment CAIMAN which takes into account different phenomena studied in analytical experiments and the global experiment PHEBUS PF, not only devoted to iodine behavior study. In the following text we will present the needs of IODINE code and these different experiments. (author).

  8. Present status of iodine research at IPSN

    International Nuclear Information System (INIS)

    Bardelay, J.

    1996-01-01

    Since several years, IPSN has conducted an effort in order to evaluate the release of radioactive iodine in case of hypothetical severe accident in a realistic manner. This source-term evaluation is performed with IODE code which is a module of the EXCADRE system of codes. This code is validated against: -analytical experiments: in these experiments, IPSN studies radiolytic effects and chemical processes in the sump, organic formation, mass transfer, effect of spray (CARAIDAS experiment), - the CAIMAN semi global experiment; this experiment will allow to study the phenomena linked to iodine behavior under representative containment geometry in the presence of painted surfaces and global irradiation, - the PHEBUS FP program. The paper consists to describe succinctly the current status of IODE and the various experiments for its validation. In case of hypothetical severe accident iodine can induce important perturbations of human organism. The effects are principally radiological, in particular on the thyroid. At short term, radioactive iodine is the most important contributor for the sanitary risk. It represents 55% of effective dose and 92% of thyroid dose at 10 km in case of controlled rejects with current assumptions. This is the reason why it must be actively studied. In France, the safety evaluations are performed with mechanistic codes or lumped parameter codes like EXCADRE which contains a module devoted to iodine studies: IODINE. The objective of the French experimental program on iodine is to understand and quantify important phenomena in order to put kinetic parameters in IODE module. The experiments can be classified in analytical experiments, the semi-global experiment CAIMAN which takes into account different phenomena studied in analytical experiments and the global experiment PHEBUS PF, not only devoted to iodine behavior study. In the following text we will present the needs of IODINE code and these different experiments. (author)

  9. Present Status of Inclusive Rare $B$ Decays

    CERN Document Server

    Hurth, Tobias

    2003-01-01

    We give a status report on inclusive rare B decays, highlighting recent developments and open problems. We focus on the decay modes $B \\to X_{s,d} \\gamma$, $ B \\to X_s \\ell^+\\ell^-$ and $B \\to X_s \

  10. Present status of the ETL LINAC facility

    International Nuclear Information System (INIS)

    Suzuki, Ryoichi; Mikado, Tomohisa; Ohgaki, Hideaki

    1993-01-01

    The ETL LINAC has been operated for the beam injection to the storage rings NIJI-II, III, IV, and TERAS, and for the generation of an intense slow positron beam. The status of the ETL LINAC on the operations, the maintenances, and the improvements is described. (author)

  11. Facial nerve palsy as a primary presentation of advanced carcinoma ...

    African Journals Online (AJOL)

    A. Abdulkadir

    2016-07-02

    Jul 2, 2016 ... advanced carcinoma of the prostate: An unusual occurrence. A. Abdulkadira,∗ ... PSA was 116 ng/ml and the six cores of the digital guided prostate biopsy taken all .... Benign prostatic hyperplasia and prostate carcinoma in ...

  12. Neutrino Oscillations Present Status and Future Plans

    CERN Document Server

    Thomas, Jennifer

    2008-01-01

    This book reviews the status of a very exciting field - neutrino oscillations - at a very important time. The fact that neutrinos have mass has only been proved in the last few years and the acceptance of that fact has opened up a whole new area of study to understand the fundamental parameters of the mixing matrix. The book summarizes the results from all the experiments which have played a role in the measurement of neutrino oscillations and briefly describes the scope of some new planned experiments. Contributions include a theoretical introduction by Stephen Parke from FNAL, as well as art

  13. Verrucous carcinoma of the hand: a rare presentation evaluated by magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, Jailson Rodrigues; Rosemberg, Laercio Alberto; Lourenco, Rafael Burgomeister; Cerri, Giovanni Guido [Universidade de Sao Paulo (InRad/HC/USP), SP (Brazil). Hospital das Clinicas. Inst. de Radiologia; Rodrigues, Marcelo Bordalo [Universidade de Sao Paulo (IOT/HC/USP), SP (Brazil). Hospital das Clinicas. Instituto de Ortopedia e Traumatologia

    2011-07-15

    Verrucous carcinoma is a variant of squamous cell carcinoma seen in mucous membranes and skin, and rarely found in the hand. The present report describes a case of two lesions on the dorsum of the hand, with no contact to each other, which underwent en-block resection and were confirmed as verrucous carcinoma. (author)

  14. Verrucous carcinoma of the hand: a rare presentation evaluated by magnetic resonance imaging

    International Nuclear Information System (INIS)

    Lopes, Jailson Rodrigues; Rosemberg, Laercio Alberto; Lourenco, Rafael Burgomeister; Cerri, Giovanni Guido; Rodrigues, Marcelo Bordalo

    2011-01-01

    Verrucous carcinoma is a variant of squamous cell carcinoma seen in mucous membranes and skin, and rarely found in the hand. The present report describes a case of two lesions on the dorsum of the hand, with no contact to each other, which underwent en-block resection and were confirmed as verrucous carcinoma. (author)

  15. Present status of nuclear containments in Korea

    International Nuclear Information System (INIS)

    Park, Jihong; Hong, Jaekeun; Lee, Byunghoon; Son, Youngho

    2007-01-01

    Since the first nuclear power plant in Korea, Kori unit no.1, was started in commercial service in 1978, 20 units including Kori unit no.1 have been operated and maintained until now in Korea. Recently several units were started to be constructed and also, additionally more than 4 units were planned to be constructed in the near future. The importance of nuclear containments has been always one of the hottest issues for the safety and protection of nuclear power plants until now. At the beginning of nuclear power plants construction in Korea, several typed nuclear containment systems were adopted. For those reasons, various codes, standards, and inspection technologies are applied to nuclear containment systems differently. In this study, the status of inservice inspection performed for the safety and maintenance of nuclear containments in Korea was researched. Overall nuclear containment systems and inspections performed up to recently in Korea including trends, inspection items, periods, and regulations were described briefly. (author)

  16. Epidermal Growth Factor Receptor and K-RAS status in two cohorts of squamous cell carcinomas

    International Nuclear Information System (INIS)

    Van Damme, Nancy; Pauwels, Patrick; Peeters, Marc; Deron, Philippe; Van Roy, Nadine; Demetter, Pieter; Bols, Alain; Dorpe, Jo Van; Baert, Filip; Van Laethem, Jean-Luc; Speleman, Franki

    2010-01-01

    With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important. The aim of this study was to analyse EGFR expression, EGFR gene copy number and EGFR and K-RAS mutations in two cohorts of squamous cell carcinomas, specifically anal canal and tonsil carcinomas. Formalin fixed, paraffin-embedded tissues from anal and tonsil carcinoma were used. EGFR protein expression and EGFR gene copy number were analysed by means of immunohistochemistry and fluorescence in situ hybridisation. The somatic status of the EGFR gene was investigated by PCR using primers specific for exons 18 through 21. For the K-RAS gene, PCR was performed using exon 2 specific primers. EGFR immunoreactivity was present in 36/43 (83.7%) of anal canal and in 20/24 (83.3%) of tonsil squamous cell carcinomas. EGFR amplification was absent in anal canal tumours (0/23), but could be identified in 4 of 24 tonsil tumours. From 38 anal canal specimens, 26 specimens were successfully analysed for exon 18, 30 for exon 19, 34 for exon 20 and 30 for exon 21. No EGFR mutations were found in the investigated samples. Thirty samples were sequenced for K-RAS exon 2 and no mutation was identified. From 24 tonsil specimens, 22 were successfully analysed for exon 18 and all 24 specimens for exon 19, 20 and 21. No EGFR mutations were found. Twenty-two samples were sequenced for K-RAS exon 2 and one mutation c.53C > A was identified. EGFR mutations were absent from squamous cell carcinoma of the anus and tonsils, but EGFR protein expression was detected in the majority of the cases. EGFR amplification was seen in tonsil but not in anal canal carcinomas. In our investigated panel, only one mutation in the K-RAS gene of a tonsil squamous cell carcinoma was identified. This indicates that EGFR and K-RAS mutation analysis is not

  17. Epidermal Growth Factor Receptor and K-RAS status in two cohorts of squamous cell carcinomas

    Directory of Open Access Journals (Sweden)

    Van Laethem Jean-Luc

    2010-05-01

    Full Text Available Abstract Background With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important. The aim of this study was to analyse EGFR expression, EGFR gene copy number and EGFR and K-RAS mutations in two cohorts of squamous cell carcinomas, specifically anal canal and tonsil carcinomas. Methods Formalin fixed, paraffin-embedded tissues from anal and tonsil carcinoma were used. EGFR protein expression and EGFR gene copy number were analysed by means of immunohistochemistry and fluorescence in situ hybridisation. The somatic status of the EGFR gene was investigated by PCR using primers specific for exons 18 through 21. For the K-RAS gene, PCR was performed using exon 2 specific primers. Results EGFR immunoreactivity was present in 36/43 (83.7% of anal canal and in 20/24 (83.3% of tonsil squamous cell carcinomas. EGFR amplification was absent in anal canal tumours (0/23, but could be identified in 4 of 24 tonsil tumours. From 38 anal canal specimens, 26 specimens were successfully analysed for exon 18, 30 for exon 19, 34 for exon 20 and 30 for exon 21. No EGFR mutations were found in the investigated samples. Thirty samples were sequenced for K-RAS exon 2 and no mutation was identified. From 24 tonsil specimens, 22 were successfully analysed for exon 18 and all 24 specimens for exon 19, 20 and 21. No EGFR mutations were found. Twenty-two samples were sequenced for K-RAS exon 2 and one mutation c.53C > A was identified. Conclusion EGFR mutations were absent from squamous cell carcinoma of the anus and tonsils, but EGFR protein expression was detected in the majority of the cases. EGFR amplification was seen in tonsil but not in anal canal carcinomas. In our investigated panel, only one mutation in the K-RAS gene of a tonsil squamous cell carcinoma was identified

  18. Metastatic Breast Carcinoma Presenting as a Sigmoid Stricture: Report of a Case and Review of the Literature

    Directory of Open Access Journals (Sweden)

    A. Nikkar-Esfahani

    2013-03-01

    Full Text Available Metastatic spread of breast carcinoma to the colon and rectum is rare. We report the case of a patient treated for lobular breast carcinoma presenting 17 years later with metastatic breast cancer of the colon. A 63-year-old lady with a past history of right-sided invasive lobular carcinoma of the breast presented with persistent diarrhoea. Colonoscopy with biopsies revealed a benign-looking stricture at the rectosigmoid junction. A CT scan of the abdomen and pelvis revealed a benign-looking stricture in keeping with a probable diverticular stricture. A Hartmann procedure was performed and histology revealed a metastatic lobular carcinoma with oestrogen and progesterone receptor-positive status. Treatment was commenced with letrozole and the patient remains well under clinical surveillance. In a patient with a history of breast carcinoma who presents with gastrointestinal symptoms the possibility of gastrointestinal tract spread should always be considered. Endoscopic diagnosis may be misleading with pathological diagnosis only being made following surgical resection. A history of breast carcinoma must be declared to the histopathologist following surgical resection so that an accurate diagnosis is made and appropriate treatment is commenced.

  19. Recurrent invasive lobular carcinoma presenting as a ruptured breast implant

    International Nuclear Information System (INIS)

    Botros, Maikel; Chang, Kenneth; Miller, Robert; Krishnan, Sunil; Iott, Matthew

    2011-01-01

    For years, the treatment for invasive lobular carcinoma (ILC) has been mastectomy secondary to the lack of studies investigating the efficacy of breast conservation therapy on patients afflicted with ILC and due to the lack of long-term follow up investigating locoregional recurrence in this patient population. In this article we report the clinical course of a patient diagnosed with ILC. We describe the case of a 50-year-old woman with stage IIB (T2N1M0) ER/PR positive right breast ILC who underwent a right modified radical mastectomy, postoperative chemotherapy, a prophylactic left simple mastectomy with bilateral breast reconstruction and tamoxifen. Approximately 12 years later, she presented with a deflated breast implant and recurrent breast cancer with metastatic spread. She received palliative radiotherapy then palliative chemotherapy. Unfortunately, she succumbed to the cancer less than a year after being diagnosed with metastatic disease. This may be the first case report of a ruptured breast implant presenting at the same time as the diagnosis of recurrent breast cancer

  20. The carcinomas tongue-incidence risk factor, presentation and treatment

    International Nuclear Information System (INIS)

    Asif, M.; Mazafar, K.

    2000-01-01

    The tongue is one of the common site for the development of carcinoma in the oral cavity. A prospective study was done from 1st January 1995 to 30th November, 1995. A total of 47 new cases of the oral cavity cancer were seen during this period. Out of which 10 (21.3%) cases were of tongue carcinoma and it was found to be the commonest tumor of the oral cavity. Surgery was the best option for early lesions. (author)

  1. Present status of Accelerator-Based BNCT.

    Science.gov (United States)

    Kreiner, Andres Juan; Bergueiro, Javier; Cartelli, Daniel; Baldo, Matias; Castell, Walter; Asoia, Javier Gomez; Padulo, Javier; Suárez Sandín, Juan Carlos; Igarzabal, Marcelo; Erhardt, Julian; Mercuri, Daniel; Valda, Alejandro A; Minsky, Daniel M; Debray, Mario E; Somacal, Hector R; Capoulat, María Eugenia; Herrera, María S; Del Grosso, Mariela F; Gagetti, Leonardo; Anzorena, Manuel Suarez; Canepa, Nicolas; Real, Nicolas; Gun, Marcelo; Tacca, Hernán

    2016-01-01

    This work aims at giving an updated report of the worldwide status of Accelerator-Based BNCT (AB-BNCT). There is a generalized perception that the availability of accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of BNCT. Accordingly, in recent years a significant effort has started to develop such machines. A variety of possible charged-particle induced nuclear reactions and the characteristics of the resulting neutron spectra are discussed along with the worldwide activity in suitable accelerator development. Endothermic (7)Li(p,n)(7)Be and (9)Be(p,n)(9)B and exothermic (9)Be(d,n)(10)B are compared. In addition to having much better thermo-mechanical properties than Li, Be as a target leads to stable products. This is a significant advantage for a hospital-based facility. (9)Be(p,n)(9)B needs at least 4-5 MeV bombarding energy to have a sufficient yield, while (9)Be(d,n)(10)B can be utilized at about 1.4 MeV, implying the smallest possible accelerator. This reaction operating with a thin target can produce a sufficiently soft spectrum to be viable for AB-BNCT. The machines considered are electrostatic single ended or tandem accelerators or radiofrequency quadrupoles plus drift tube Linacs. (7)Li(p,n)(7)Be provides one of the best solutions for the production of epithermal neutron beams for deep-seated tumors. However, a Li-based target poses significant technological challenges. Hence, Be has been considered as an alternative target, both in combination with (p,n) and (d,n) reactions. (9)Be(d,n)(10)B at 1.4 MeV, with a thin target has been shown to be a realistic option for the treatment of deep-seated lesions.

  2. Present status of radiation processing in Japan

    International Nuclear Information System (INIS)

    Tabata, Y.

    1984-01-01

    Crosslinking of insulating materials including cables, tubes, sheets, pipes and polymer foam, curing of coating, surface treatment and other processes developed recently will be presented. Future prospects in this field will be discussed. (Author) [pt

  3. Oxygenation status of cervical carcinomas before and during spinal anesthesia for application of brachytherapy

    International Nuclear Information System (INIS)

    Weitmann, H.D.; Knocke, T.H.; Poetter, R.; Gustorff, B.; Vaupel, P.

    2003-01-01

    Background and Purpose: To date, no information is available concerning the impact of spinal anesthesia on the oxygenation status of carcinomas of the uterine cervix. The aim of this study was therefore to determine the influence of spinal anesthesia on the oxygenation status of cervical carcinomas. Patients and Methods: In ten patients with cervical carcinoma who received spinal anesthesia for a first application of brachytherapy, intratumoral pO 2 measurements (pO 2 histography system, Eppendorf-Netheler-Hinz, Hamburg, Germany) were performed. Systemic parameters were documented prior to and during spinal anesthesia. Patients breathed room air spontaneously. For further evaluation, all intratumoral pO 2 values were pooled, and overall median pO 2 values and fractions of hypoxic pO 2 values ≤ 5 mm Hg were calculated. Overall median pO 2 values in the subcutis were also calculated. Results: There were no significant changes of systemic parameters, median subcutaneous pO 2 values, median intratumoral pO 2 values, and the fractions of hypoxic pO 2 values ≤ 5 mm Hg in the tumor upon administration of spinal anesthesia. The variability of measured pO 2 values increased during spinal anesthesia, although substantial changes in the oxygenation status were only seen in individual cases (n = 2). Conclusion: This study shows for the first time that the oxygenation status of cervical carcinomas, in general, is not influenced by spinal anesthesia prior to application of brachytherapy. To conclude, the data presented suggest that reliable pO 2 measurements can be performed under spinal anesthesia. At the same time, since no substantial changes in tumor oxygenation were observed, spinal anesthesia should not affect the O 2 -related efficacy of high-dose-rate brachytherapy. (orig.)

  4. A rare case of vulvar squamous cell carcinoma; case presentation

    Directory of Open Access Journals (Sweden)

    Cristina N. Cozma

    2018-05-01

    Full Text Available Objectives. Vulvar cancer is a rare gynecological malignancy, with an incidence of 1.5 per 100 000 women/year. The most common vulvar cancer is developed in squamous cells, the most encountered type of skin cells. Case report. We report a case of a 72-year-old female admitted in the Department of Plastic Surgery of Emergency Clinical Hospital “Prof. Dr. Agrippa Ionescu” with a 5/4.2 cm painful ulcerated tumoral mass located in the vulvar area. The lesion slowly increased in size over the past 12 months. The tumour was surgically removed with oncological safety margins and sent for histopathological evaluation. The histopathological examination revealed an ulcerated squamous carcinoma with lymphovascular and perineural invasion, but with negative margins. Postoperative results were favorable, and no local or general complications were observed. Conclusion. We highlight this case due to its unusual presentation in the clitoral area. Moreover, considering the potential for recurrence we point out the importance of the radical vulvectomy with regional lymphadenectomy and histopathological examination, in order to put a precise diagnosis and ensure the best possible treatment for the patient.

  5. IAEA Safeguards: Present status and experience gained

    International Nuclear Information System (INIS)

    Thorne, L.; Buechler, C.; Haegglund, E.

    1983-01-01

    IAEA safeguards are at the present under critical review with regard to their purpose and effectiveness. This paper describes the development of the IAEA Safeguards System from the early days, when procedures were developed on an ad hoc basis, to the present day. The development of State Systems of Accounting for and Control of Nuclear Material (SSAC), and of sophisticated instrumentation, has been necessary to deal with the rapid growth in the quantities of nuclear material and in the number of facilities under safeguards. The paper also discusses some of the managerial and organizational issues that are inherent in such a large international inspectorate. (author)

  6. The Transuranium Elements - Present Status: Nobel Lecture

    Science.gov (United States)

    Seaborg, G. T.

    1951-12-12

    The discovery of the transuranium elements and the work done on them up to the present time are reviewed. The properties of these elements, their relationship to other elements, their place in the periodic table, and the possibility of production and identification of other transuranium elements are discussed briefly.

  7. Present status of NCS in France

    International Nuclear Information System (INIS)

    Boutaine, J.L.

    2000-01-01

    About 3700 industrial plants are presently using nucleonic gauges for various aspects of production quality. The major industrial end users are oil and gas industry, coal and mineral ore processing, paper and plastic industries. New development in nucleonic instrumentation and processing software is going on. (author)

  8. Solar neutrino results and present status

    International Nuclear Information System (INIS)

    Gorbachev, V.V.; Abdurashitov, J.N.; Gavrin, V.N.; Girin, S.V.; Gurkina, P.P.; Ibragimova, T.V.; Kalikhov, A.V.; Khairnasov, N.G.; Knodel, T.V.; Mirmov, I.N.; Shikhin, A.A.; Veretenkin, E.P.; Vermul, V.M.; Yants, V.E.; Zatsepin, G.T.; Bowles, T.J.; Teasdale, W.A.; Cherry, M.L.; Cleveland, B.T.; Elliott, S.R.

    2002-01-01

    The solar neutrino capture rate measured by the Russian-American Gallium Experiment on a metallic gallium target SAGE during the time from January 1990 through December 2000 is 77.0 +6.2 -6.2 +3.5 -3.0 SNU, where the uncertainties are statistical and systematic, respectively. The experimental procedures and data analysis are presented

  9. Quantitative possibility analysis. Present status in ESCA

    International Nuclear Information System (INIS)

    Brion, D.

    1981-01-01

    A short review of the recent developments in quantification of X-ray photoelectron spectroscopy or ESCA is presented. The basic equations are reminded. Each involved parameter (photoionisation, inelastic mean free paths, 'response function' of the instruments, intensity measurement) is separately discussed in relation with the accuracy and the precision of the method. Other topics are considered such as roughness, surface contamination, matrix effect and inhomogeneous composition. Some aspects of the quantitative ESCA analysis and AES analysis are compared [fr

  10. Red Dot Basal Cell Carcinoma: Report of Cases and Review of This Unique Presentation of Basal Cell Carcinoma.

    Science.gov (United States)

    Cohen, Philip R

    2017-03-22

    Red dot basal cell carcinoma is a unique variant of basal cell carcinoma. Including the three patients described in this report, red dot basal cell carcinoma has only been described in seven individuals. This paper describes the features of two males and one female with red dot basal cell carcinoma and reviews the characteristics of other patients with this clinical subtype of basal cell carcinoma. A 70-year-old male developed a pearly-colored papule with a red dot in the center on his nasal tip. A 71-year-old male developed a red dot surrounded by a flesh-colored papule on his left nostril. Lastly, a 74-year-old female developed a red dot within an area of erythema on her left mid back. Biopsy of the lesions all showed nodular and/or superficial basal cell carcinoma. Correlation of the clinical presentation and pathology established the diagnosis of red dot basal cell carcinoma. The tumors were treated by excision using the Mohs surgical technique. Pubmed was searched with the keyword: basal, cell, cancer, carcinoma, dot, red, and skin. The papers generated by the search and their references were reviewed. Red dot basal cell carcinoma has been described in three females and two males; the gender was not reported in two patients. The tumor was located on the nose (five patients), back (one patient) and thigh (one patient). Cancer presented as a solitary small red macule or papule; often, the carcinoma was surrounded by erythema or a flesh-colored papule. Although basal cell carcinomas usually do not blanch after a glass microscope slide is pressed against them, the red dot basal cell carcinoma blanched after diascopy in two of the patients, resulting in a delay of diagnosis in one of these individuals. Dermoscopy may be a useful non-invasive modality for evaluating skin lesions when the diagnosis of red dot basal cell carcinoma is considered. Mohs surgery is the treatment of choice; in some of the patients, the ratio of the area of the postoperative wound to that

  11. Present status of the Zavratec remediation project

    International Nuclear Information System (INIS)

    Zeleznik, N.; Stepisnik, M.; Mele, I.

    1997-01-01

    In 1992 the responsibility for the remediation of the temporary storage of radioactive waste near Zavratec was assigned to the Agency for Radwaste Management. The project was divided into two phases. First, in a study, different options for remediation were considered. In the second phase, performed in 1996, the measurements, inventorying and repacking of radioactive waste were carried out. Simultaneously with these activities a programme for covering public relations was prepared. One of the results of the public relation campaign is also a 15-minute video film, which was prepared from documentary material recorded during remedial activities, and will be presented here. (author)

  12. Present status of PIK gadolinium control

    International Nuclear Information System (INIS)

    Petrov, Yu.V.; Garusov, E.A.; Shustov, V.A.

    1994-01-01

    A liquid control element (LCE) containing a water solution of gadolinium nitrate Gd(NO 3 ) 3 was originally planned for use at the PIK reactor for partial compensation of poisoning and fuel burnup [1-3]. However, a further analysis has shown that quick forcing-out, boiling up or flowing-out of the absorbing solution (though of low probability) can lead to the dangerous prompt overcriticality of the reactor. The results of the analysis are presented as well as the upper limit of the reactivity, quick insertion of which still is safe for the reactor (J.P.N.)

  13. Present status and prospect of copper radiopharmaceuticals

    International Nuclear Information System (INIS)

    Chen Huawei; Li Hongfeng; Liu Boli

    1996-01-01

    In the past decade most of the efforts of copper radiopharmaceuticals research has been focused on bis(thiosemicarbazonato) copper complexes for use in myocardial and brain imaging agents. In the present work, the analogs of bis(thiosemicarbazone) is studied in labeling antibodies and tumors. The retention mechanism of Cu-PTSM is investigated. Other kinds of ligands, BAT (N 2 S 2 ) for example, can be used to prepare neutral copper complexes in order to obtain brain radiopharmaceuticals in future. (60 refs.)

  14. Present status of uranium extraction from seawater

    International Nuclear Information System (INIS)

    Kusakabe, Katsuki; Morooka, Shigeharu

    1993-01-01

    For the research on the extraction of uranium from seawater, various processes have been examined, but the most promising process is adsorption. Its key point is the performance of the adsorbent. The system as compact as possible, in which a large quantity of seawater effectively contacts with the adsorbent, must be constructed economically. As the inorganic adsorbent, titanium oxide is the best, but organic amidoxime is superior to it. The present state of the development of the adsorbent, the rate of adsorption of the adsorbenbt, the seawater uranium adsorption system and the experiment in Imari Bay are reported. (K.I.)

  15. Present status of laser fusion fuel pellet

    International Nuclear Information System (INIS)

    Nakai, Sadao; Mima, Kunioki; Norimatsu, Takayoshi; Takagi, Masaru.

    1986-01-01

    Accompanying the advance of pellet implosion experiment, the data base required for fuel pellet design has been steadily accumulated. The clarification of the physics related to the process of absorbing laser beam, energy transport, the generation of ablative pressure, the hydrodynamic mechanism of implosion, the energy transmission to fuel core and so on progressed, and the design data supported by these results are prepared. Based on the data base like this, the design of fuel pellets taking the optimization of implosion in consideration is carried out. The various fuel pellets designed in this way are tested for their effectiveness by implosion experiment. For this purpose, the high performance measurement of implosion and the high accuracy manufacture of fuel pellets become very important. In this paper, the present state of the research on the method of laser implosion, the example of pellet design and the law of proportion, the manufacturing techniques of the fuel pellets having various structures, the techniques dealing with tritium and so on is summarized, and the direction of future research and development is ascertained. At present, implosion experiment is carried out mostly by hanging a pellet target with a fiber of several μm diameter, but the fiber impairs the symmetry of implosion. The levitation techniques without contact is required. (Kako, I.)

  16. Evidence for a dualistic model of high-grade serous carcinoma: BRCA mutation status, histology, and tubal intraepithelial carcinoma.

    Science.gov (United States)

    Howitt, Brooke E; Hanamornroongruang, Suchanan; Lin, Douglas I; Conner, James E; Schulte, Stephanie; Horowitz, Neil; Crum, Christopher P; Meserve, Emily E

    2015-03-01

    Most early adnexal carcinomas detected in asymptomatic women with germline BRCA mutations (BRCA) present as serous tubal intraepithelial carcinomas (STIC). However, STICs are found in only ∼40% of symptomatic high-grade serous carcinomas (HGSCs) and less frequently in pseudoendometrioid variants of HGSC. Consecutive cases of untreated HGSC from BRCA and BRCA women with detailed fallopian tube examination (SEE-FIM protocol) were compared. STIC status (+/-) was determined, and tumors were classified morphologically as SET ("SET", >50% solid, pseudoendometrioid, or transitional) or classic predominate ("Classic"). SET tumors trended toward a higher frequency in BRCA versus BRCA women (50% vs. 28%, P=0.11), had a significantly younger mean age than those with classic HGSC in BRCA women (mean 56.2 vs. 64.8 y, P=0.04), and displayed a better clinical outcome in both groups combined (P=0.024). STIC was significantly more frequent in tumors from the BRCA cohort (66% vs. 31%, P=0.017) and specifically the BRCA tumors with classic morphology (83%) versus those with SET morphology (22%, P=0.003). Overall, several covariables-histology, BRCA status, age, coexisting STIC, and response to therapy-define 2 categories of HGSC with differences in precursor (STIC) frequency, morphology, and outcome. We introduce a dualistic HGSC model that could shed light on the differences in frequency of STIC between symptomatic and asymptomatic women with HGSC. This model emphasizes the need for further study of HGSC precursors to determine their relevance to the prevention of this lethal malignancy.

  17. The present status of safeguards in Turkey

    International Nuclear Information System (INIS)

    Yilmazer, A.; Yuecel, A.

    2001-01-01

    Republic of Turkey signed Non-Proliferation Treaty (NPT) in Vienna, Austria on January 28, 1969 and the Treaty was ratified by Turkish Parliament on March 29, 1979. International Atomic Energy Agency (IAEA) and Republic of Turkey signed the Safeguards Agreement on June 30, 1981. Turkey accepted the international safeguards administered by IAEA and at the same time its subsidiary arrangements and Facility attachments were enforced for all nuclear facilities as an Non-Nuclear-Weapon State party to NPT. Regulation on Nuclear Materials Accounting and Control, which was prepared in accordance with Agreement Between the Government of Turkey and IAEA for the application of Safeguard in Connection with the Treaty on NPT, has been put into force since it was published in Official Gazette on September 10, 1997. This study presents the essential futures of national system of accounting for and control of nuclear materials in Turkey

  18. Present status of the KISS project

    Science.gov (United States)

    Miyatake, H.; Wada, M.; Watanabe, X. Y.; Hirayama, Y.; Schury, P.; Ahmed, M.; Ishiyama, H.; Jeong, S. C.; Kakiguchi, Y.; Kimura, S.; Moon, J. Y.; Mukai, M.; Oyaizu, M.; Park, J. H.

    2018-04-01

    KISS project aims at finding an astrophysical condition for synthesizing r-process heavy element isotopes, which are characterized as the third peak in the solar abundance pattern. This is an experimental challenge in nuclear physics to measure ground and isomeric state properties of unknown nuclei around the region of N=126 isotones. So far we have constructed and developed new type of mass separation system, KISS (KEK Isotope Separation System) and performed measurements of lifetimes and hyperfine structures of some platinum and iridium neutron-rich radioactive isotopes by applying multi-nucleon transfer reactions and in-gas laser ionization and spectroscopy (IGLIS) methods. In this report, recent physics results, updated KISS performance, and future's research plan including a challenge of a systematic mass measurement with MRTOF (Multi-Reflection Time-Of-Flight mass spectrograph) are presented.

  19. Sarcomatoid carcinoma of kidney, presenting with leucocytosis as paraneoplastic syndrome: A case report and short review

    Directory of Open Access Journals (Sweden)

    Joydeep Ghosh

    2017-01-01

    Full Text Available Renal cell carcinoma is the ninth most common malignancy. The commonest histopathological type is clear cell carcinoma. The occurrence of sarcomatoid carcinoma is very rare and confers a very poor prognosis. Only 10-20% patients present with paraneoplastic syndromes. Out of the common paraneoplastic syndromes, leucocytosis is one of the least reported. Here, we present a case of sarcomatoid carcinoma of kidney who presented with low-grade fever and leucocytosis, followed by a short review of literature. This is one of the rare situations where a rare histologic variant presents with a rare finding.

  20. Female, Black, and Unmarried Patients Are More Likely to Present With Metastatic Bladder Urothelial Carcinoma.

    Science.gov (United States)

    Klaassen, Zachary; DiBianco, John M; Jen, Rita P; Evans, Austin J; Reinstatler, Lael; Terris, Martha K; Madi, Rabii

    2016-10-01

    Although there are well-established risk factors for the diagnosis of bladder cancer, there is no consensus regarding risk factors for presentation of advanced or metastatic disease at diagnosis. The objective of this study was to identify the demographic and clinical factors associated with metastasis at diagnosis in patients with bladder urothelial carcinoma. Patients diagnosed with bladder urothelial carcinoma from 2004 to 2010 were identified in the Surveillance, Epidemiology, and End Results (SEER) database (n = 108,417). The primary outcome was metastatic disease at the time of diagnosis. Demographic and socioeconomic variables were analyzed, and multivariable logistic regression models were performed to generate odds ratios (OR) for factors associated with metastasis at diagnosis. Of patients with bladder cancer, 3018 (2.8%) had metastasis at diagnosis and 105,399 (97.2%) had nonmetastatic disease. Patients with metastatic disease at diagnosis were more frequently female (29.6% vs. 23.6%, P vs. 5.0%, P unmarried (44.1% vs. 32.5%, P vs. male, OR 1.21), black race (vs. white, OR 1.71), unmarried (vs. married, OR 1.46), unemployed (OR 1.02), and foreign-born status (OR 1.01). Female gender, black race, unmarried, unemployed, and foreign-born status are independently associated with metastasis at diagnosis for bladder urothelial carcinoma. All clinicians should be aware of these potential health care disparities in order to involve social services and other support mechanisms in efforts to improve early care. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Recent Developments and Present Status of Telepathology

    Directory of Open Access Journals (Sweden)

    K. Kayser

    2000-01-01

    Full Text Available Telepathology which is the diagnostic work of a pathologist at a distance has been developed to routine application within the last ten years. It can be classified in relation to application, technical solutions, or performance conditions. Diagnostic pathology performance distinguishes primary diagnosis (for example, frozen section statement from secondary diagnosis (for example, expert consultation and quality assurance (diagnostic accuracy, continuous education and training. Applications comprise (a frozen section service; (b expert consultations; (c remote control measurements; and (d education and training. The technical solutions distinguish active (remote control, live imaging systems from passive (conventional microscope handling, static imaging, and the performance systems with interactive (on‐line, live imaging use from those with passive (off‐line, static imaging practice. Intra‐operative frozen section service is mainly performed with remote control systems; whereas expert consultations and education/training are commonly based upon Internet connections with static imaging in an off‐line mode. The image quality, transfer rates, and screen resolution of active and passive telepathology systems are sufficient for an additional or primary judgment of histological slides and cytological smears. From the technical point of view, remote control telepathology requires a fast transfer and at least near on‐line judgement of images, i.e., image acquisition, transfer and presentation can be considered one performance function. Thus, image size, line transfer rate and screen resolution define the practicability of the system. In expert consultation, the pixel resolution of images and natural color presentation are the main factors for diagnostic support, whereas the line transfer rate is of minor importance. These conditions define the technical compartments, especially size and resolution of camera and screen. The performance of

  2. Fibrolamellar hepatocellular carcinoma with ovarian metastasis - an unusual presentation.

    Science.gov (United States)

    Ciurea, Silviu Horia; Matei, Emil; Stănescu, CodruŢ Silvian; Lupescu, Ioana Gabriela; Boroş, Mirela; Herlea, Vlad; Luca, Niculina Ioana; DorobanŢu, Bogdan Mihail

    2017-01-01

    Fibrolamellar carcinoma (FLC) has been considered a distinct clinical entity vs. hepatocellular carcinoma, with respect to its epidemiology, etiology, and prognosis. We describe the unusual case of a 23-year-old female patient with FLC and ovarian (Krukenberg) and peritoneal metastases, clinically mimicking an ovarian carcinoma. Multiple recurrences occurred despite initial R0 resection and chemotherapy, requiring surgical treatment. The patient survived five years and died from generalized disease. The particularities of our case are discussed by comparison with the other two similar cases and other date from the literature. To our knowledge, the ovarian involvement encountered in our case is the third case published in literature, being explained by the superficial location of the liver tumor.

  3. Merkel Cell Carcinoma: The Past, the Present, and the Future

    International Nuclear Information System (INIS)

    Erovic, I.; Erovic, B. M.

    2013-01-01

    Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description of the Merkel cell to the finding of the CK20 as a highly specific diagnostic marker and finally to the recently detected Merkel cell polyoma virus (MCPyV). Moreover, we will highlight the beginning of adjuvant therapeutic regimens with radiotherapy and chemotherapy and discuss the diagnostic work-up including imaging and histology of patients with Merkel cell carcinoma. Another very rapidly growing and interesting field of research is the development of patients' specific and tailored targeted therapy, in particular in patients with distant metastatic disease.

  4. Present status and future prospects of HANARO

    International Nuclear Information System (INIS)

    Chae, Sung-Ki

    1999-01-01

    Korean industry is in the transition from component to basic material production stage, which consequently requires basic science research utilizing neutron beam to support it. The demand for medical radioisotopes is strongly increasing according to the elevation of life standards, which in turn requires very stable supply of short half-lived radioisotopes. Research on these areas is possible through the capabilities provided by horizontal beam tubes and vertical experimental holes of HANARO. The experimental facilities are available not only for in-house research and development groups but also for external user communities in universities, research institutes and industries. And they are open to the international users as well. Utilization of a research reactor will be enhanced through the active development of user programs and the strengthened cooperation between supplier and users of the facility. Most of the worldwide high performance research reactors of the first generation are reaching end of life. Hence the construction of new research reactors and the refurbishment of present ones are very demanding because research reactors continue to be utilized in many areas. Since HANARO is recently constructed with a new design, experiences of design, construction, and commissioning work for the research reactor are valuable for our country and for other countries as well. As more utilization facilities are being designed and installed in the reactor, international cooperation with experienced institutions is important in the course of installation. Sharing experiences will contribute to the advancement of nuclear technologies for international communities. (author)

  5. Present status of radiation education in Bangladesh

    International Nuclear Information System (INIS)

    Ullah, Sana

    1999-01-01

    Radioisotopes and Radiation are being widely used in the fields of agriculture, medicine, industry for the benefit of people throughout the world. At the same time the use of radiation sources can do harm to man and environment. In order to ensure the satiety against radiation hazards and safe use of radiation, proper education, training, knowledge and awareness are essential. Like other achieve economic development through application f count rues Bangladesh is flying to in agriculture, food, industry, power; health or medi of isotopes and radiation technology cine. Basic education about radiation is incorporated in the school curriculum. Courses on radiation are also given in college and university education. Research organizations, universities carry out research and development works on different disciplines using radiation and radioisotopes. Seminars, workshops, conferences, takings on isotopes and radiation are also being organized. In 1993 Government of Bangladesh passed the Nuclear Satiety and Radiation Control Act 1993 for see use of radiation. The present paper win cover the radiation education, research and development works on radiation, applications of radiation in agriculture, medicine and industry, personal safety and radiation protection against radiation hazard and rules and regulations of the nuclear safety and radiation control act practised in Bangladesh. (author)

  6. Primary energy: present status and future perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Thielheim, K O

    1982-01-01

    A survey of the base-load energy sources available to humans is presented, starting from the point of view that all energy used is ultimately derived from nuclear processes within the sun. Specific note is made of European energy options, noting the large dependence on imported oil. Detailed exploration of available nuclear fuel resources is carried out, with attention given to fission, fusion, and breeder reactor plants and to the state-of-the-art and technology for each. The problems of nuclear waste disposal are discussed, and long term burial in salt domes is outlined as a satisfactory method of containing the materials for acceptable periods of time. The CO/sub 2/ greenhouse effect hazards caused by increased usage of coal-derived fuels are considered and precautions to be taken on a global scale to ameliorate the warming effects are recommended. The limitations to hydropower are examined, as are those of tidal power. Solar cells are projected to be produced in GW quantities by the year 2000, while wind-derived electricity is predicted to provide a minimum of 5% of the world energy needs in the future.

  7. Present status of radiation education in Bangladesh

    Energy Technology Data Exchange (ETDEWEB)

    Ullah, Sana [Atomic Energy Centre, Dhaka (Bangladesh)

    1999-09-01

    Radioisotopes and Radiation are being widely used in the fields of agriculture, medicine, industry for the benefit of people throughout the world. At the same time the use of radiation sources can do harm to man and environment. In order to ensure the satiety against radiation hazards and safe use of radiation, proper education, training, knowledge and awareness are essential. Like other achieve economic development through application f count rues Bangladesh is flying to in agriculture, food, industry, power; health or medi of isotopes and radiation technology cine. Basic education about radiation is incorporated in the school curriculum. Courses on radiation are also given in college and university education. Research organizations, universities carry out research and development works on different disciplines using radiation and radioisotopes. Seminars, workshops, conferences, takings on isotopes and radiation are also being organized. In 1993 Government of Bangladesh passed the Nuclear Satiety and Radiation Control Act 1993 for see use of radiation. The present paper win cover the radiation education, research and development works on radiation, applications of radiation in agriculture, medicine and industry, personal safety and radiation protection against radiation hazard and rules and regulations of the nuclear safety and radiation control act practised in Bangladesh. (author)

  8. Present status of radioisotope production in JAERI

    International Nuclear Information System (INIS)

    Yamabayashi, Hisamichi

    1994-01-01

    Since 1962, the technology for producing a wide variety of processed radioisotopes and sealed radiation sources has been developed by using the reactors, JRR-1, JRR-2, JRR-3, JRR-4 and JMTR, and the products have been offered to domestic users. At present, 31 products of 29 nuclides are on the list of processed radioisotopes. Some of those isotopes such as P-32, S-35, Cr-51 and short lived nuclides are produced for regular distribution, but the rest are produced upon request. The radiation sources of Co-60 needles for industrial use, Ir-192 pellets for the nondestructive inspection of pipelines, Gd-153 pellets for the diagnosis of born mineral and seven kinds of brachy therapy Ir-192 and Au-198 grains are produced and distributed regularly. The organic compounds labeled with H-3 and C-14 are widely used. In fiscal year 1992, 34 batches and total amount 12 TBq of processed radioisotopes and 100 batches, 1.2 PBq of radiation sources were produced as scheduled. The development of the techniques for producing the sources emitting high energy β ray used for the diagnosis and treatment of cancer is in progress. The method of producing new isotopes is developed. (K.I.)

  9. Present Status of GNF New Nodal Simulator

    International Nuclear Information System (INIS)

    Iwamoto, T.; Tamitani, M.; Moore, B.

    2001-01-01

    This paper presents core simulator consolidation work done at Global Nuclear Fuel (GNF). The unified simulator needs to supercede the capabilities of past simulator packages from the original GNF partners: GE, Hitachi, and Toshiba. At the same time, an effort is being made to produce a simulation package that will be a state-of-the-art analysis tool when released, in terms of the physics solution methodology and functionality. The core simulator will be capable and qualified for (a) high-energy cycles in the U.S. markets, (b) mixed-oxide (MOX) introduction in Japan, and (c) high-power density plants in Europe, etc. The unification of the lattice physics code is also in progress based on a transport model with collision probability methods. The AETNA core simulator is built upon the PANAC11 software base. The goal is to essentially replace the 1.5-energy-group model with a higher-order multigroup nonlinear nodal solution capable of the required modeling fidelity, while keeping highly automated library generation as well as functionality. All required interfaces to PANAC11 will be preserved, which minimizes the impact on users and process automation. Preliminary results show statistical accuracy improvement over the 1.5-group model

  10. Present status of LAM-80ET

    International Nuclear Information System (INIS)

    Izumi, Y.

    1990-01-01

    The present report briefly describes major aspects of a quasielastic neutron scattering spectrometer installed at KEK (National Laboratory for High Energy Physics, Japan). It is a latticed array mirror (LAM) spectrometer for measuring the neutron TOF which employs the KENS spallation cold neutron source and crystal analyzer mirror. This spectrometer is a very useful device to study diffusive motion or the relaxation process in molecular science and in many other fields. By measuring the quasielastic neutron scattering, one can obtain useful information for the analysis of temporal and spatial properties of atoms and molecules which are in random motion with a characteristic time of 10 -12 to 10 -9 seconds. The report then outlines major design considerations and some details of down-scattering crystal spectrometer LAM-80ET which uses a mica analyzer. Its configuration is shown and discussed. The LAM-80ET spectrometer incorporates a LAM-type analyzer mirror. Its performance is then outlined focusing on its resolution. The LAM-80ET spectrometer has demonstrated a satisfactory performance particularly in tunneling study of N-oxy γ picoline. Usefulness of the 20 K methane pulsed cold source has also been demonstrated. (N.K.)

  11. Male ductal carcinoma in situ presenting as bloody nipple discharge: a case report and literature review.

    Science.gov (United States)

    Simmons, Rache M

    2002-01-01

    Male breast carcinoma accounts for 1% of all diagnosed breast carcinoma. Pure ductal carcinoma in situ in men is extremely rare. Unfortunately, male breast cancer is often diagnosed at a late stage because of the minimal awareness of presenting symptoms by the patient and sometimes by the health care provider. Because of this late presentation, the overall prognosis is less favorable. This case is presented to emphasize the importance of recognizing bloody nipple discharge as a clinical sign of male ductal carcinoma in situ and an opportunity for early diagnosis.

  12. A CLINICAL STUDY ON CARCINOMA BREAST IN RELATION TO ER AND PR STATUS

    Directory of Open Access Journals (Sweden)

    Ramanaiah

    2015-09-01

    Full Text Available INTRODUCTION : Breast carcinoma is the most common malignant tumor and the leading cause of death in women worldwide 1 . It accounts for 15 % of all cancer deaths 2 . According to the World Health Organisation (WHO, approximately 70% of breast cancers occur in women with none of the known risk factors. Only about 5% of breast cancers are inherited. Various protocols are in use for the assessment of prognosis, and also to assist further management of these cases. Of various parameters, expression of hormonereceptors Estrogen receptor (ER and Progesterone receptor (PR ar e significant AIMS AND OBJECTIVES : To study the occurrence of ER and PR status in breast cancer patients attending S.V.R.R.G.G. Hospital. To correlate the expression of prognostic factors like age at presentation menarche, menopause, parity, tumor size, number of lymph nodes, metastasis histology, grading with ER and PR status. MATERIALS AND METHODS : This clinic opathological study of carcinoma breast was carried out in patients admitted to SVRRGG Hospital, Tirupati during the period from September 2011 to August 2013 after obtaining approval from scientific committee and ethical committee .Forty cases of breast carcinoma were taken into study. The clinical study done by interviewing, detailed examination and subjecting to relevant investigations and surgeries depending upon the stage of the disease. Excised specimen is sent for Histopathological examination in 10% formaline Reports of light microscopy (Hematoxilin and Eosin and immunohistochemistry on tumor histology including MBR (Modified Bloom Richardson grading and Estrogen and Progesterone status is analysed. CONCLUSION: In conclusion, ER and PR status correlates well with histopathological grading and other clinico - pathological parameters. Higher grade is associated with ER PR negativity. Hence. Immunohistochemical assessment of ER and PR status should be incorporated as a routine investigation. This along with

  13. Primary Amoebic (Naegleria fowleri Meningoencephalitis Presenting as Status Epilepticus

    Directory of Open Access Journals (Sweden)

    A Sharma

    2011-04-01

    Full Text Available Primary amebic meningoencephalitis (PAM is a rare entity. Usual presenting features are fever, headache and seizures with meningeal signs and this disease carries high mortality rate. We present a case report of PAM presenting as status epilepticus.

  14. Severe Anemia with Hemoperitoneum as a First Presentation for Multinodular Hepatocellular Carcinoma: A Rare Event in Western Countries

    Directory of Open Access Journals (Sweden)

    Thein Swe

    2016-01-01

    Full Text Available Hemoperitoneum due to spontaneous rupture of hepatocellular carcinoma is a life-threatening and rare condition in western countries with an incidence of less than 3% because of early detection of cirrhosis and neoplasm. Here, we describe a case of a 66-year-old male patient with altered mental status with hemorrhagic shock. Computed tomography scan of abdomen revealed hemoperitoneum and mass in liver. Patient underwent resection of liver tumor and biopsy revealed multinodular hepatocellular carcinoma. A high degree of suspicion is required where severe anemia and hemoperitoneum can be a first presentation for hepatocellular carcinoma especially in patients with chronic hepatitis C infection. Early diagnosis is crucial since mortality rates remain high for untreated cases.

  15. A patient presenting with spinal cord compression who had two distinct follicular cell type thyroid carcinomas.

    Science.gov (United States)

    Koca, E; Sokmensuer, C; Yildiz, B O; Engin, H; Bozkurt, M F; Aras, T; Barista, I; Gurlek, A

    2004-06-01

    A 61-yr-old woman presented with complaints of weakness and pain in her legs. A magnetic resonance imaging showed a 3 x 5.6 x 7.8 cm mass lesion destructing the T1 and T2 vertebral bodies and compressing the spinal cord. The mass was excised surgically. It was follicular carcinoma metastasis of the cervicodorsal region. Then, she underwent a total thyroidectomy. Pathological examination showed two different types of carcinomas in two different focuses; follicular carcinoma in the left lobe and follicular variant papillary carcinoma in the isthmic lobe. After the operation she was given 100 mCi 131I. This is the first report of a patient who had both metastatic follicular carcinoma and follicular variant papillary carcinoma together.

  16. Biliary Dyskinesia as a Rare Presentation of Metastatic Breast Carcinoma of the Gallbladder: A Case Report

    Directory of Open Access Journals (Sweden)

    A. Markelov

    2011-01-01

    Full Text Available Background. Breast carcinoma is the most common malignancy in women worldwide. It is most commonly associated with metastases to the liver, lung, bone, and the brain. Invasive lobular carcinoma is a less common pathology with slightly higher metastases to the upper gastrointestinal tract. Invasive lobular carcinoma metastasis to the gallbladder is extremely rare. Method. In this paper we are presenting a case of a 67-year-old female with metastases of invasive lobular breast cancer to the gallbladder six years after her therapy. Conclusion. This case clearly signifies the nature of the micrometastatic foci of the invasive lobular carcinoma even many years after a successful treatment.

  17. What effects performance status of patients with hepatocellular carcinoma: stage of tumor versus underlying liver status

    International Nuclear Information System (INIS)

    Sarwar, S.; Tarique, S.

    2015-01-01

    Objective: To identify variables associated with poor performance status of hepatocellular carcinoma (HCC) patients and to compare impact of stage of liver disease and that of hepatoma on functional status of patient. Patients and Methods: We included 254 confirmed cases of liver cancer in a crosssectional analytical study carried out at Doctors Hospital Lahore. Patient's clinical, biochemical and radiological variables were correlated with Karnofsky's performance status (KPS) using pearson correlation. Model for End stage Liver Disease (MELD) and Cancer of Liver Italian Program (CLIP) were evaluated for predicting performance status using Receiver Operating Characteristic (ROC) curve. Results: Mean age of patients was 56.69 (±10.34) and male to female ratio was 2.47: 1 (181/73). On KPS evaluation 84 (33.1%) patients scored between 80-100, 147 (57.9%) had score of 50-70 while in 23 (9.1%) KPS score was between 0-40. Variables associated with poor performance status were bilirubin> 3mg/dl (p value 0.00), albumin< 2.5 g/dl (p value 0.00), creatinine > 1.2mg/dl (p 0.00), prothrombin time> 16seconds (p value 0.00), size of tumor >7cm (p value 0.02), tumor involving > 50% of liver mass (p value 0.00) and vascular invasion (p value 0.00). Both stage of liver disease as determined by MELD and stage of liver cancer as per CLIP scores had strong correlation (p value 0.00) with poor performance status of patient. Area under ROC curve was 0.764 for MELD score and 0.785 for CLIP score. Conclusion: Performance status of liver cancer patients is affected by both stage of liver disease and that of liver tumor. Patients with MELD score above 16 and CLIP score above 4 have poor performance status. (author)

  18. CARCINOMA OF THE BREAST: THE STATUS OF PRESENT ...

    African Journals Online (AJOL)

    operable breast cancer.' He argued ... IV. Skin oedema or ulceration or skin nodules or acute inflammation. Dif- ... leaving cancer cells behind is most unattractive, especially ..... gether with vitamins Band C. Vomiting ceased in 48 hours and ...

  19. Squamous cell carcinoma presenting with trigeminal anesthesia: An uncommon presentation of head & neck cancer with unknown primary.

    Science.gov (United States)

    Shah, Ameer T; Dagher, Walid I; O'Leary, Miriam A; Wein, Richard O

    The differential diagnosis of facial anesthesia is vast. This may be secondary to trauma, neoplasm, both intracranial and extracranial, infection, and neurologic disease. When evaluating a patient with isolated facial anesthesia, the head and neck surgeon often thinks of adenoid cystic carcinoma, which has a propensity for perineural invasion and spread. When one thinks of head and neck squamous cell carcinoma with or without unknown primary, the typical presentation involves dysphagia, odynophagia, weight loss, hoarseness, or more commonly, a neck mass. Squamous cell carcinoma presenting as facial anesthesia and perineural spread, with no primary site is quite rare. Case presentations and review of the literature. Trigeminal anesthesia is an uncommon presentation of head and neck squamous cell carcinoma with unknown primary. We present two interesting cases of invasive squamous cell carcinoma of the trigeminal nerve, with no primary site identified. We will also review the literature of head and neck malignancies with perineural spread and the management techniques for the two different cases presented. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. A case of nonconvulsive status epilepticus presenting as ...

    African Journals Online (AJOL)

    Nonconvulsive status epilepticus is characterised by changes in behaviour, memory, affect or level of consciousness. We report a case of nonconvulsive status epilepticus precipitated by carbamazepine that presented as dissociative fugue. The patient was a 49-year-old man. He first experienced a tonic-clonic seizure nine ...

  1. Anaplastic Carcinoma and Toxic Multinodular Goiter: An Unusual Presentation

    Science.gov (United States)

    Marcelino, Mafalda; Marques, Pedro; Lopes, Luis; Leite, Valeriano; de Castro, João Jácome

    2014-01-01

    A 70-year-old male was referred with hyperthyroidism and multinodular goiter (MNG). Thyroid ultrasonography showed 2 nodules, one in the isthmus and the other in the left lobe, 51 and 38 mm in diameter, respectively. Neck CT showed a large MNG, thyroid scintigraphy showed increased uptake in the nodule in the left lobe, and fine-needle aspiration biopsy showed a benign cytology of the nodule in the isthmus. The patient declined surgery and was treated with methimazole. After being lost to follow-up for 3 years, the patient returned with complaints of dyspnea, dysphagia, and hoarseness; he was still hyperthyroid. Cervical CT showed a large mass in the isthmus and left lobe with invasion of surrounding tissues, the trachea, the esophagus, and the recurrent laryngeal nerve. Bronchoscopy showed extensive infiltration and compression of the trachea to 20% of its caliber. A tracheal biopsy revealed an anaplastic thyroid carcinoma. The tumor was considered unresectable, and radiotherapy was given. One month later, the patient died. The association between a toxic thyroid nodule and anaplastic thyroid carcinoma has apparently not been reported so far. PMID:25759806

  2. Metastatic nonpalpable invasive lobular breast carcinoma presenting as rectal stenosis: a case report.

    Science.gov (United States)

    Osaku, Tadatoshi; Ogata, Hideaki; Magoshi, Shunsuke; Kubota, Yorichika; Saito, Fumi; Kanazawa, Shinsaku; Kaneko, Hironori

    2015-04-24

    Invasive lobular carcinomas have an increased propensity for distant metastases, particularly to the peritoneum, ovaries, and uterus. In contrast, distant metastases of nonpalpable lobular carcinomas are extremely rare, and the causes of underlying symptoms of primary carcinomas remain unclear. We report a case of an asymptomatic invasive lobular carcinoma with a primary mammary lesion in a patient with rectal stenosis. A 69-year-old Japanese woman presented to our hospital for treatment of constipation. Although rectal stenosis was confirmed, thorough testing of her lower digestive tract did not identify its cause. Thus, an exploratory laparotomy and tissue biopsy was performed, and the presence of an invasive lobular carcinoma was confirmed. Subsequent breast examinations showed that the invasive lobular carcinoma that led to the rectal stenosis was a metastatic lesion from a primary lesion of the breast duct. As the present breast lobular carcinoma was asymptomatic and nonpalpable, we did not initially consider metastatic breast cancer as a cause of her symptoms, and the final diagnosis was delayed. Peritoneal metastasis from nonpalpable invasive lobular carcinomas is very rare. However, breast cancer metastasis should be considered when carcinomatous peritonitis is present in a patient with an unknown primary cancer.

  3. Collision tumours, squamous cell carcinoma of larynx, papillary thyroid carcinoma, metastatic lymphatic node. Clinical Presentation

    International Nuclear Information System (INIS)

    Villalba, V; Gomez, R; Yoffe, I.; Liu, T.; Arias, J.; Quiroz, J.; Gonzalez, M; Ayala, E.

    2010-01-01

    Male patient with 35 years old, merchant from Capiata, no history of smoking or alcoholism, with 2 months history of bilateral neck nodes, sore throat, weight loss of 8 kg., dysphonia, progressive dyspne a on medium efforts dyspne a at rest so you see the urgency of the Hospital de Clinicas. On examination: lucid, collaborator, normosomico, with dysphonia, stri dor and dyspne a. P S: 2. No hemodynamic or fever. Neck: tumor mass of 6 cm in diameter, infrahiodea right, accompanying the movement of swallowing, bilateral jugular carotid lymphadenopathy high of 2 cm in diameter, solid-elastic smooth, mobile; lymphadenopathy average lower right carotid and jugular similar characteristics. Laryngoscopy smooth, submucosal, nodular lesion on right vocal cord, paralytic in middle position; aritenoides edematous law, glottal gap of 10%. Mobile left vocal cord. Remainder of the examination: Normal. Emergency tracheotomy performed. Biopsy of the lesion: invasive carcinoma, without other specifications. Laboratory tests: Hb: 11gr% eosinophilia. ECG, Rx. Chest and abdominal ultrasound: within normal limits. CT: tumor mass of 4.5 cm in diameter in right vocal cord, which is in middle position, and infiltrates the thyroid cartilage soft tissue. In thyroid lobe right: node 5 cm diameter. Cervical lymphadenopathy 2 cm in diameter in bilateral high carotid jugular region, medium and low carotid jugular right. 2/9/09 Surgery: Tumor infiltrating infrahiodea right muscles, jugular Total laryngectomy with bilateral carotid dissection, level 2,3 and 4. Right Thyroid lobectomy. Infrahiodea muscle resection. Pathology: 1-larynx neoplasms consist collision, poorly differentiated right infraglotis (3.2 cm.) Keratinizing squamous carcinoma infiltrating focally in depth the laryngeal cartilage through it, and a papillary carcinoma right thyroid lobe (3.4 cm.) massively infiltrating peritiroideo fibroadipose and skeletal muscle tissue infiltrating through the laryngeal cartilage and extending to

  4. On the present status of the ARAMAKO system

    International Nuclear Information System (INIS)

    Nikolaev, M.N.; Savos'kin, M.M.

    1987-01-01

    This paper reviews the present status of the ARAMAKO multigroup constant calculation system for solving neutron and gamma quantum transport equations and for calculations of linear and bilinear functionals of their fields. (author)

  5. Present status of the TOHOKU 300 MeV linac

    International Nuclear Information System (INIS)

    Takahashi, Shigenobu; Oyamada, Masayuki; Urasawa, Shigekazu; Nakazato, Toshiharu; Kurihara, Akira; Mutoh, Masakatu; Shibasaki, Yoshinobu; Oonuma, Tadahiro

    1993-01-01

    The TOHOKU linac that was constructed about a quarter century before has been operated without serious trouble recently. This report describes as follows: main trouble, maintenance, present performance of the machine and status of operation. (author)

  6. Carcinoma lung: Clinical presentation, diagnosis, and its surgical management

    Directory of Open Access Journals (Sweden)

    Farooq Ahmad Ganie

    2013-01-01

    Full Text Available The aim of this article is to review the surgical management of lung carcinoma. Lung cancer is the most common cancer in the world, and a leading cause of death in men and women. By any conventional measure, the enormity of this global problem is immense. In some countries incidence and mortality rates have peaked and are beginning to decline. In many developing nations, the burden of disease is rising and will continue to rise because of aggressive tobacco industry marketing which is leading to a growing prevalence of cigarette smoking. This is also one of the major causes of cancer deaths in our Kashmir valley. The method of literature search was from articles published in PubMed and Google Scholar.

  7. Two breast metastases from thyroid carcinoma presented 6 years later after total thyroidectomy: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Gene Hyuk; Kang, Bong Joo; Kim, Sung Hun; Lee, Ah Won [Seoul St. Mary' s Hospital, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of); Jung, Na Young [Dept. of Radiology, Bucheon St. Mary' s Hospital, College of Medicine, The Catholic University of Korea, Bucheon (Korea, Republic of)

    2016-04-15

    Thyroid carcinoma is usually indolent with good prognosis, as compared to other malignancy. Distant metastases from thyroid cancer are rare and usually manifest as multiple lesions especially in lungs, bones and lymph nodes, in advanced stages of the disease. Metastasis to the breast from thyroid carcinoma is extremely rare, with about 16 cases reported in the English literature. Herein, we reported a case of metastatic poorly differentiated thyroid carcinoma, which presented as 2 breast masses in a 72-year-old woman, 6 years after total thyroidectomy for papillary thyroid carcinoma. Although the computed tomography (CT) and ultrasonography (USG) image findings are nonspecific oval mass with circumscribed or partially indistinct margin, metastases from thyroid cancer should be included in the differential diagnosis when recurrence of thyroid carcinoma is suspected. Also, fusion images of CT and USG are helpful to the radiologists in localizing the targeted lesion and conducting accurate USG-guided biopsy.

  8. Integration of nuclear power in the Portuguese network. Present status

    International Nuclear Information System (INIS)

    Videira, F.M.

    1977-01-01

    The main characteristics of the Portuguese electric energy production system and their evolution in the past and near future are presented. Taking into consideration the Portuguese energy resources the alternatives to meet the additional long range electric energy needs are evaluated. Finally some comments are made about the present status of the nuclear option. (Auth.)

  9. The impact of HPV status on weight loss and feeding tube use in oropharyngeal carcinoma.

    Science.gov (United States)

    Vangelov, Belinda; Kotevski, Damian P; Williams, Janet R; Smee, Robert I

    2018-04-01

    It has been well established that patients with oropharyngeal carcinoma are at high nutritional risk, with significant weight loss and tube feeding common. Human papillomavirus (HPV)-associated disease has led to a change in the "typical" presentation and nutritional profile of this population. The aim of our study was to determine whether the need for a feeding tube, and weight loss during radiotherapy (RT) in patients with oropharyngeal carcinoma differed with HPV status. Patients who received curative RT ± chemotherapy from January 2011 to January 2016 were included (n = 100). We retrospectively evaluated feeding tube use and timing of insertion (prophylactic vs reactive), percentage weight loss during RT and the prevalence of critical weight loss (CWL) ≥5%. HPV-positive patients had significantly higher weight loss during RT compared to the rest of the cohort (8.4% vs 6.1%, 95%CI 0.8-3.9, p = 0.003). CWL was observed in 86% and in a higher proportion with HPV-positive disease (93%, p = 0.011). Conditional probability modelling analysis revealed, with 74% accuracy, concurrent chemoradiotherapy and HPV-positive status were predictors of CWL when comparing HPV-positive patients to HPV-negative (96%, p = 0.001 and 98%, p = 0.012 respectively). More HPV-positive patients required feeding tubes (n = 43, 63%, p = 0.05), most being reactive (n = 27, 63%). All patients with reactive tubes experienced CWL. The high incidence of CWL in patients with HPV-positive oropharyngeal carcinoma is of concern. Tube feeding continues to be a necessary nutritional intervention in this population and predicting who will require a tube is challenging. Larger, prospective cohort studies are required. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Status Cataplecticus as Initial Presentation of Late Onset Narcolepsy

    Science.gov (United States)

    Panda, Samhita

    2014-01-01

    Narcolepsy, one of the important causes of hypersomnia, is an under diagnosed sleep disorder. It has a bimodal age of onset around 15 and 35 years. It is characterized by the tetrad of excessive daytime sleepiness, cataplexy, hypnagogic/ hypnopompic hallucinations, and sleep paralysis. Cataplexy is by far the most predictive feature of narcolepsy. Status cataplecticus is the occurrence of cataplexy repeatedly for hours or days, a rare presentation of narcolepsy. This report describes an elderly gentleman with late onset narcolepsy in the sixth decade of life presenting with initial and chief symptom of status cataplecticus. Citation: Panda S. Status cataplecticus as initial presentation of late onset narcolepsy. J Clin Sleep Med 2014;10(2):207-209. PMID:24533005

  11. An Atypical Presentation Of Pancreatic Carcinoma With Malignant ...

    African Journals Online (AJOL)

    Background: Pleural effusion secondary to pancreatic tumour is a relatively rare clinical presentation. Aim of study: To present a case of a patient that had pancreatic tumour who presented with features of left sided pleural effusion with a view to highlighting the clinical features of the presentation. Method of study: The case ...

  12. The present status of artificial intelligence for nuclear power plants

    International Nuclear Information System (INIS)

    Suda, Kazunori; Yonekawa, Tuyoshi; Yoshikawa, Shinji; Hasegawa, Makoto

    1999-03-01

    JNC researches the development of distributed intelligence systems at autonomous plants and intelligent support system at nuclear power plant. This report describes the present status of artificial intelligence (AI) technologies for this research. The following are represented in this report: present research study for AI, Implementation of AI system and application of AI technologies in the field of industries, requirement for AI by industries, problems of social acceptance for AI. A development of AI systems has to be motivated both by current status of AI and requirement for AI. Furthermore a problem of social acceptance for AI technologies has to be solved for using AI systems in society. (author)

  13. Present status and perspectives of nuclear power in Latin America

    International Nuclear Information System (INIS)

    Mondino, M.A.

    1995-01-01

    The paper describes the present status of nuclear power in Latin America, giving an analysis of Argentina, Brazil, Cuba and Mexico - the countries that have committed themselves to nuclear power undertakings. The historical development of the energy sector is studied and analysed, comparing Latin America with developed countries and groups of countries. Projected data are also studied and analysed, defining the present status of nuclear power in Latin American and its future possibilities. The region's future needs are analyzed on the basis of various indicators and the most important conclusions are highlighted. (author). 10 refs, 9 figs, 21 tabs

  14. Aquamous cell carcinomas of the lung which presented as numerous polypoid nodules in the tracheobronchial tree: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyun Gyu; Choi, Yo Won; Yoon, Hyun Jung; Paik, Seung Sam [Hanyang University Hospital, Hanyang University College of Medicine, Seoul (Korea, Republic of)

    2017-03-15

    We report a case of squamous cell carcinomas of the lung, which presented as numerous polypoid nodules in the tracheobronchial tree. They occurred at two years and 7 months after resection of squamous cell carcinoma, which presented as a lung nodule in the left lower lobe, and at 7 months after resection of tracheal squamous cell carcinoma.

  15. Aquamous cell carcinomas of the lung which presented as numerous polypoid nodules in the tracheobronchial tree: A case report

    International Nuclear Information System (INIS)

    Lee, Hyun Gyu; Choi, Yo Won; Yoon, Hyun Jung; Paik, Seung Sam

    2017-01-01

    We report a case of squamous cell carcinomas of the lung, which presented as numerous polypoid nodules in the tracheobronchial tree. They occurred at two years and 7 months after resection of squamous cell carcinoma, which presented as a lung nodule in the left lower lobe, and at 7 months after resection of tracheal squamous cell carcinoma

  16. Facial nerve palsy as a primary presentation of advanced carcinoma ...

    African Journals Online (AJOL)

    Introduction: Cranial nerve neuropathy is a rare presentation of advanced cancer of the prostate. Observation: We report a case of 65-year-old man who presented with right lower motor neuron (LMN) facial nerve palsy. The prostate had malignant features on digital rectal examination (DRE) and the prostate specific antigen ...

  17. Cosmic microwave background: present status and future prospects

    International Nuclear Information System (INIS)

    Muller, R.A.

    1978-12-01

    After a brief review of the origin of the radiation according to the standard model, the status of present measurements of the spectrum and the large-scale isotropy is discussed. Finally, it is indicated what are the prospects for improved measurements in the next decade. 17 references

  18. Transmutation of radioactive nuclear waste – present status and ...

    Indian Academy of Sciences (India)

    Transmutation of long-lived actinides and fission products becomes an important issue of the overall nuclear fuel cycle assessment, both for existing and future reactor systems. Reliable nuclear data are required for analysis of associated neutronics. The present paper gives a review of the status of nuclear data analysis ...

  19. Present status and expected progress in radiation processing dosimetry

    DEFF Research Database (Denmark)

    Kovács, A.; Miller, A.

    2004-01-01

    The paper describes the present status of radiation processing dosimetry including the methods used most widely in gamma- and electron processing as well as the new methods under development or introduction. The recent trends with respect to calibrationof routine dosimetry systems as well...

  20. Pulmonary Embolism as the Initial Presentation of Testicular Carcinoma

    Science.gov (United States)

    Berber, Ilhami; Erkurt, Mehmet Ali; Ulutas, Ozkan; Ediz, Caner; Nizam, Ilknur; Kırıcı Berber, Nurcan; Unlu, Serkan; Koroglu, Reyhan; Koroglu, Mustafa; Akpolat, Nusret

    2013-01-01

    Objective. The risk of pulmonary embolism is well recognized as showing an increase in oncological patients. We report a case presenting with pulmonary embolism initially, which was then diagnosed with testicular cancer. Clinical Presentation and Intervention. A 25-year-old man was admitted to the emergency department with a complaint of dyspnoea. Thoracic tomography, lung ventilation/perfusion scintigraphy, and an increased D-dimer level revealed pulmonary embolism. For the aetiology of pulmonary embolism, a left orchiectomy was performed and the patient was diagnosed with a germinal cell tumour of the testicle. Conclusion. In this paper, we present a patient for whom pulmonary embolism was the initial presentation, and a germinal cell tumour was diagnosed later during the search for the aetiology. PMID:24383024

  1. Peculiarities of immune status in uterine cervix carcinoma patients

    International Nuclear Information System (INIS)

    Dekster, L.I.

    1981-01-01

    On the basis of investigating the peripheral blood lymphocytes the immunologic state in 81 patients with uterine cervix carcinoma is estimated. It is established that there is a considerable decrease of indices in the T-immune system in patients with uterine cervix carcinoma. The detection of reductions in the immunogram indices in the initial stage plays a definte diagnostic role in the detection of metastases, permits to forecast the process generalization, and consequently, to determine the treatment tactics. It is established that under the effect of combined radiation treatment the T-system is mostly injured. Consequently, pronounced postradiation depression is prognostically unfavourable. The examination of another group of patients has shown that the probability of development of lymphogenic metastases in uterine cervix carcinoma is mainly determined by immuno-morphological peculiarities of regional lymph nodes [ru

  2. Present status and needs of research on severe core damage

    International Nuclear Information System (INIS)

    1982-05-01

    The needs for research on severe core damage accident have been emphasized recently, in particular, since TMI-2 accident. The Severe Core Damage Research Task Force was established by the Divisions of Reactor Safety and Reactor Safety Evaluation to evaluate individual phenomenon, to survey the present status of research and to provide the recommended research subjects on severe accidents. This report describes the accident phenomena involving some analytical results, status of research and recommended research subjects on severe core damage accidents, divided into accident sequence, fuel damage, and molten material behavior, fission product behavior, hydrogen generation and combustion, steam explosion and containment integrity. (author)

  3. Present status of the radiative neutron capture mechanisms -nonstatistical effects

    International Nuclear Information System (INIS)

    Brzosko, J.S.

    1976-01-01

    The present status of our knowledge about neutron radiative capture mechanisms is described. In the first section there are given a review on mathematical description of the neutron capture cross section and possible sources of correlation effects. The point of lecture is the explanation of connections between the intermediate structures and correlation effects. In one of the sections the explanation of the bump in γ-ray spectra is discussed. The typical experimental results are presented. (author)

  4. Bupropion Overdose Presenting as Status Epilepticus in an Infant.

    Science.gov (United States)

    Rivas-Coppola, Marianna S; Patterson, Amy L; Morgan, Robin; Wheless, James W

    2015-09-01

    Bupropion is a monocyclic antidepressant in the aminoketone class, structurally related to amphetamines. The Food and Drug Administration withdrew this product from the market in 1986 after seizures were reported in bulimic patients. It was later reintroduced in 1989 when the incidence of seizures was shown to be dose-related in the immediate release preparation. Massive bupropion ingestion has been associated with status epilepticus and cardiogenic shock in adults. Seizures have been reported in children, but not status epilepticus. This report highlights a patient who presented with status epilepticus and developed cardiopulmonary arrest after bupropion ingestion. False-positive amphetamine diagnosis from urine drug screen on presentation was reported. We review the presentation, clinical course, diagnostic studies, and outcome of this patient. We then review the literature regarding bupropion overdose in children. Symptoms of bupropion toxicity and risk for seizures are dose-dependent and fatalities have been reported. Our patient developed status epilepticus and cardiopulmonary arrest and then progressed to have a hypoxic ischemic encephalopathy and refractory symptomatic partial seizures. Our report highlights the need to keep this medication away from children in order to prevent accidental overdose. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Primary carcinoma of Anterior Urethra Presenting as a Benign ...

    African Journals Online (AJOL)

    Relevant literature search was also done. Result: A 43 year old man presented with a four month history of progressive diminution of urine stream associated with obstructive lower urinary tract symptoms and acute urinary retention. There was no history of trauma, but he had a past history of urethritis 15 years earlier which ...

  6. Cautionary case of Double Carcinoma Presenting as Acute ...

    African Journals Online (AJOL)

    Primary malignant neoplasms have been of great interest for a long time. A historical review mentioned the commoner combinations of organs and exemplified with primary cancer of the urinary bladder being associated with that of the uterine cervix, bowel, pharynx or prostate. The present study reports its association with ...

  7. Alopecia neoplastica: An uncommon presentation of metastatic breast carcinoma

    Directory of Open Access Journals (Sweden)

    Felipe Ladeira de Oliveira

    2016-12-01

    Full Text Available Cutaneous metastasis may correspond to the initial clinical presentation of hidden internal malignancies. In patients presenting said neoplasia, clinical manifestations of breast cancer reaches 23.9%. Considering that neoplastic alopecia appears as an unusual pattern of the said metastasis, this report describes a case of such uncommon neoplastic alopecia which presents itself as a cutaneous metastasis of rapid progression in a patient with prior breast cancer history. We present a 47-year-old female patient reporting lesions at the scalp, and who was asymptomatic with a 1-year evolution. The patient reported prior breast cancer history and presence of lung metastasis, and was undergoing chemotherapy at the time of consultation. A dermatological evaluation showed only a nodular lesion with erythematous surface and a diameter measuring about 4 cm, firm in consistency, and immovable. She was routed to the Department of Dermatological Surgery, and the results from histopathology were consistent with a diagnosis of metastatic breast adenocarcinoma. Neoplastic alopecia appears as an unusual form of cutaneous metastasis which is predominantly described in association with breast cancer. The lesion’s clinical features play a crucial role at the differential diagnosis, as the presence of erythema could distinguish neoplastic alopecia from alopecia areata. The existence of cutaneous metastasis leads to unfavorable outcomes. As a conclusion, cutaneous evaluation of patients is essential for treating visceral metastases, since the forms of cutaneous metastasis are diverse and can also affect the scalp.

  8. Primary signet-ring cell carcinoma of vermiform appendix clinically and pathologically presenting as acute appendicitis

    Directory of Open Access Journals (Sweden)

    Tadashi Terada, MD, PhD

    2014-03-01

    Full Text Available Primary signet-ring cell carcinoma (SRCC of vermiform appendix is extremely rare; only three cases have been reported in the English literature. An 89-year-old man suddenly presented right lower abdominal pain, and transferred to a hospital, where he was diagnosed with acute appendicitis by physical data, blood data, and CT. He was further transferred to our hospital for emergency operation. Physical examination showed positive abdominal pain, Blunberg sign, and Rosenstein sign. Blood test showed leukocytosis and increased C-reactive protein. An appendectomy was performed. Gross examination during operation showed inflamed appendix, appendiceal adhesion, and acute peritonitis. Gross pathological examination showed no apparent tumor, but the proximal appendix showed wall thickening and luminal occlusion. The appendix was cut into three sections, and was observed under microscopically. Nests of carcinoma cells were seen in the proximal appendix. The carcinoma was composed of SRCC (70% and mucinous carcinoma (30%. The size of carcinoma was 6 × 7 mm. The carcinoma cells invaded into muscular layer. No lymphovascular permeation was seen. The cut margins were negative for carcinoma cells. Immunohistochemically, SRCC cells were positive for cytokeratin (CK AE1/3, CK CAM5.2, CK8, CK18, CK19, CK20, EMA, CEA, CA19-9, p53, Ki-67 (labeling = 30%, CDX2, MUC2, and MUC5AC. They were negative for CK34PE1, CK5/6, CK7, CK14, p63, vimentin, TTF-1, MUC1, MUC 5AC, NSE, synaptophysin, chromogranin, and CD56. No further treatments were performed, because the appendiceal carcinoma was small, the surgical margins were negative and the patient was very old. He was followed up by various imaging modalities. No recurrence or metastasis is found 17 months after the operation.

  9. ATLAS experimental equipment. November 1983 workshop and present status

    International Nuclear Information System (INIS)

    1984-01-01

    The latest workshop was held in November 1983 with the purpose of presenting an overview of the experimental stations planned for ATLAS, describing the current status of each individual apparatus, soliciting final input on devices of the first phase (i.e. on those that will be ready when beams from ATLAS become available in late Spring of 1985), and discussing and collecting new ideas on equipment for the second phase. There were short presentations on the status of the various projects followed by informal discussions. The presentations mainly concentrated on new equipment for target area III, but included some descriptions of current apparatus in target area II that might also be of interest for experiments with the higher-energy beams available in area III. The meeting was well attended with approx. 50 scientists, approximately half of them from institutions outside Argonne. The present proceedings summarize the presentations and discussions of this one-day meeting. In addition we take the opportunity to include information about developments since this meeting and an update of the current status of the various experimental stations. We would like to emphasize again that outside-user input is extremely welcome

  10. Intracystic papillary carcinoma in a male as a rare presentation of breast cancer: a case report and literature review.

    LENUS (Irish Health Repository)

    Romics, Laszlo

    2009-01-01

    The term "intracystic papillary ductal carcinoma in situ" has recently changed and is now more appropriately referred to "intracystic papillary carcinoma". Intracystic papillary carcinoma in men is an extremely rare disease with only a few case presentations published in the literature so far.

  11. Presentation of Axillary Metastases from Occult Breast Carcinoma

    Institute of Scientific and Technical Information of China (English)

    Xin Wang

    2007-01-01

    Axillary presentation from occult breast cancer is uncommon and continues to be a diagnostic and therapeutic challenge to physicians.Once the diagnosis of adenocarcinoma metastatic to an axillary lymph node has been confirmed,a preoperative workup should be done.The current experience is based on several relatively small retrospective reviews and case reports.It is difficult to determine the best management of occult breast cancer.However,treatmenl of axillary Iymph node dissection is recommended for local control and complete staging information.Treatment of breast should be a choice between breast conservation with whole-breast radiotherapy and mastectomy.Adjuvant systemic treatment should be offered.

  12. Present status and perspectives for hydroelectric power in world

    International Nuclear Information System (INIS)

    Malquori, E.

    1991-01-01

    In the note a review of the present status and perspectives of hydroelectric power in the world is introduced. The present status regards, in chronological order, the last decade, as to say the works carried out in the 80ies whereas the perspectives regard the next twenty years as to say until 2010. The mentioned electric power potentiality refers to pure generation plants of great, middle and small size and to what could be achieved by already existing plants after changes and/or replacements and improvement of the machinery. Beside the figures regarding powers, great generation and pumping plants whose contribution has been and will be remarkable have been properly mentioned. The Italian contribution - civil works design, construction, and machinery supply - in the last hydroelectric development is briefly mentioned with particular reference to the developing countries

  13. A present status for dry storage of spent nuclear fuel

    Energy Technology Data Exchange (ETDEWEB)

    Bang, K. S.; Lee, J. C.; Park, H. Y.; Seo, K. S

    2003-04-01

    National policy for management of a spent nuclear fuel does not establish in Korea yet. A storage capacity of a storage pool that is to store the spent nuclear fuel will be exceeded an amount of accumulation from the first Woljin nuclear power plant in 2007. Therefore it is necessary that dry storage facility is secured to store safely the spent nuclear fuel on site of the nuclear power plant until national policy for a back-end spent nuclear fuel cycle is established. In order to store safely spent nuclear fuel, it is important that the present status and technology on dry storage of spent nuclear fuel is looked over. Therefore, the present status on dry storage of spent nuclear fuel was analyzed so as to develop dry storage system and choose a proper dry storage method domestic.

  14. Present status and future prospect of research reactors

    International Nuclear Information System (INIS)

    Takemi, Hirokatsu

    1996-01-01

    The present status of research reactors more than MW class reactor in JAERI and the Kyoto University and the small reactors in the Musashi Institute of Technology, the Rikkyo University, the Tokyo University, the Kinki University and other countries are explained in the paper. The present status of researches are reported by the topics in each field. The future researches of the beam reactor and the irradiation reactor are reviewed. On various kinds of use of research reactor and demands of neutron field of a high order, new type research reactors under investigation are explained. Recently, the reactors are used in many fields such as the basic science: the basic physics, the material science, the nuclear physics, and the nuclear chemistry and the applied science; the earth and environmental science, the biology and the medical science. (S.Y.)

  15. Croatian repository construction project - present status and main obstacles

    International Nuclear Information System (INIS)

    Kucar Dragicevic, S.; Subasic, D.; Schaller, A.; Lokner, V.; Cerskov Klika, M.

    1999-01-01

    Croatia has been preparing backgrounds for the construction of the repository for low and intermediate radioactive waste on its territory, almost for a decade, now. In the name of Hrvtaska elektroprivreda, the co-owner of the NE Krsko, APO has been co-ordinating and organising numerous activities and projects during that time period. Siting process, safety assessment, disposal technology and repository design and public acceptance issues are the main fields of activities. The overall status of the project at the moment, including the overview of the present status of the main four aspects of activities, will be presented. Relatively, big and important progress made on the project work out during the last two years, as well as the main obstacles we were faced with during that time period, will be discussed.(author)

  16. Radioisotopes and fungicide research- present status and future prospects

    International Nuclear Information System (INIS)

    Chatrath, M.S.

    1996-01-01

    The developments in pesticides and radioisotopes fields were so near to each other that at a very early stage in this history, both became linked together and their usefulness was recognised for faster development. The purpose of this communication is to illustrate the present status these techniques in fungicide research by drawing suitable examples and also to bring out the directions in which future research will be going with the aid of these tools. 72 refs

  17. A Giant Verrucous Carcinoma of the Penis Presenting with Urinary Sepsis and Angina

    Directory of Open Access Journals (Sweden)

    Michael Nomikos

    2014-01-01

    Full Text Available Penile verrucous carcinoma also known as Buschke-Löwenstein tumor in the genital region is an uncommon variant of penile carcinoma exhibiting slow, expansive growth. We present a case of a 63-year-old male who presented with a giant purulent penile mass causing urinary sepsis and angina. Regional lymph nodes were clinically negative and staging with CT scans of thorax and abdomen did not show any signs of lymph node or distant metastases. After resuscitation, radical penectomy was performed and a perineal urethrostomy was created. Histological examination revealed a Buschke-Löwenstein tumor of the penis with no invasion of corpus cavernosum and urethra.

  18. Acute paraparesis as presentation of an occult follicular thyroid carcinoma: A case report

    Directory of Open Access Journals (Sweden)

    José Miguel Baião

    Full Text Available Introduction: Follicular thyroid carcinoma is the second most frequent type of well differentiated thyroid tumours. It is usually confined to the thyroid gland, however it can metastasize in a later stage of the disease. Signs and symptoms associated with bone metastasis are rare as first clinical manifestations. Case report: An 84-year-old female complained with acute paraparesis. Magnetic resonance imaging revealed an extensive intraosseous infiltrating lesion compatible with a bone metastasis from an occult tumour. Biopsy samples were compatible with bone metastasis from a follicular thyroid carcinoma. The patient was submitted to total thyroidectomy followed by iodine ablative therapy. Discussion: Follicular thyroid carcinoma presentation with symptoms related to bone metastasis is rare. Patients with bone lesions, such as pathological fractures or compressive symptoms should be studied since they may have clinically unapparent lesions from an unknown tumour. Patients with FTC should be submitted to total thyroidectomy. Bone lesions may be addressed to improve quality of life however this decision depends on disease extent. Conclusion: Acute paraparesis is a rare form of presentation of thyroid carcinoma. These neoplasms must be taken into account when investigating metastasis to the bone from unknown neoplasms. Keywords: Acute paraparesis, Follicular thyroid carcinoma, Bone metastasis, Case report

  19. High grade serous ovarian carcinoma with serous tubal intraepithelial carcinoma in a case presented with atypical glandular cell favor neoplasm cervical cytology and dermatomyositis

    Directory of Open Access Journals (Sweden)

    Mun-Kun Hong

    2015-04-01

    Conclusion: The patient had serous carcinoma of the ovary with tubal STIC, which presented as dermatomyositis. The AGC-FN identified from a Pap smear hinted at a diagnosis of ovarian carcinoma. These presentations point to an occult malignancy in the genital tract and demand careful diagnostic workup.

  20. Superdeformation- present status and some new universal features

    International Nuclear Information System (INIS)

    Jain, A.K.; Jain, S.R.

    1995-01-01

    The present status of understanding of superdeformed (SD) bands has been presented. The puzzles raised by the experimental data have been highlighted. Besides the well known problems related to feeding and depopulation, moment of inertia and identical bands, we have also pointed out the existence of a weak oscillation in the I vs. E γ plots, the negative value for the net alignment in many SD bands and the general identical band pattern found in each mass region. Theoretical explanation for many of these features have been suggested individually but there is no single theoretical framework which would be able to explain all the features together. (author). 32 refs

  1. Present status of development of uranium resources in foreign countries

    International Nuclear Information System (INIS)

    1983-10-01

    The book with the same title as this was published in 1981. Thereafter, the necessity to correct the contents arose, such as the remarkable change in uranium market condition and the change of uranium resource policy in Australia accompanying the change of regime, accordingly, the revision was carried out by adding more new information. As the main sources of the information collected in this book, 25 materials are shown. The confirmed resources of uranium in the free world as of the beginning of 1981 amounted to 2,293,000 t U, and the estimated additional resources were 2,720,000 t U. The political system and uranium policy, the present status of uranium export, the quantity of resources and the estimated amount of deposits, the uranium production and the status of uranium exploration and development of 25 foreign countries are reported. Japan has carried out uranium development activities in Australia, Canada, Niger, Gabon, Zambia and so on. (Kako, I.)

  2. Celiac crisis presenting with status epilepticus and encephalopathy.

    Science.gov (United States)

    Hijaz, Nadia M; Bracken, Julia M; Chandratre, Sonal R

    2014-12-01

    Celiac crisis is a life-threatening presentation of celiac disease which is described in the context of classic gastrointestinal (GI) symptoms of diarrhea, leading to dehydration and electrolyte imbalance. Neurologic manifestations are atypical symptoms of celiac crisis. To the best of our knowledge, there is no published report on seizure or encephalopathy as the presenting manifestation of celiac crisis. We describe a 2-year-old boy presenting with acute status epilepticus and lethargy. Prior to presentation, he had mild abdominal distention and intermittent diarrhea. Laboratory analysis revealed hyponatremia, anemia, hypocalcemia, transaminitis, and hyperglycemia. Electroencephalography revealed severe diffuse encephalopathy, and complete infectious work-up was negative. Initial brain magnetic resonance imaging was normal; however, repeat imaging showed osmotic demyelination syndrome. Given the history of GI symptoms and hyperglycemia, celiac serology was obtained revealing elevated tissue transglutaminase, and a diagnosis was confirmed by Marsh 3c lesions in the duodenum. He significantly improved with steroid therapy in addition to adequate nutrition, fluids, and initiation of a gluten-free diet. We report herein on the first case of celiac crisis presenting with status epilepticus and encephalopathy in the absence of profound GI symptoms. Our case suggests that celiac crisis should be considered in the differential of seizures and encephalopathy in children.

  3. Correlation between HPV status at T and N sites of oropharyngeal squamous cell carcinomas

    DEFF Research Database (Denmark)

    Josiassen, Michael Vallop; Charabi, Birgitte; Lajer, Christel Braemer

    2017-01-01

    Objectives: Human papilloma virus (HPV) is known to be associated with oropharyngeal squamous cell carcinomas (OPSCC) and may potentially play a vital role in tumor metastasis. The purpose of this study was to correlate HPV status of cervical lymph node metastases with their respective primary...

  4. An Unusual Clinical Presentation of Gastrointestinal Metastasis From Invasive Lobular Carcinoma of Breast

    Directory of Open Access Journals (Sweden)

    Bathmapriya Balakrishnan MD

    2016-03-01

    Full Text Available Introduction. We present an unusual case of metastatic lobular breast carcinoma. Typical areas of metastasis include bone, gynecological organs, peritoneum, retroperitoneum, and gastrointestinal (GI tract, in order of frequency. With regard to GI metastasis, extrahepatic represents a rare site. Case. Two years after being diagnosed with invasive lobular breast carcinoma, a 61-year-old female complained of 3 months of nonspecific abdominal pain and diarrhea. A colonoscopy revealed 5 tubular adenomatous polyps in the ascending and transverse colon. Contrast computed tomography (CT of the abdomen and pelvis was done 7 months after the colonoscopy to further evaluate persistent diarrhea. The CT results were consistent with infectious or inflammatory enterocolitis. Despite conservative management, symptoms failed to improve and a repeat diagnostic colonoscopy was obtained. Random colonic biopsies revealed metastatic high-grade adenocarcinoma of the colon. Discussion. Metastatic lobular breast carcinoma to the GI tract can distort initial interpretation of endoscopic evaluation with lesions mimicking inflammation. The interval between discovery of GI metastasis and diagnosis of lobular breast cancer can vary widely from synchronous to 30 years; however, progression is most often much sooner. Nonspecific symptoms and subtle appearance of metastatic lesions may confound the diagnosis. A high index of suspicion is needed for possible metastatic spread to the GI tract in patients with a history of invasive lobular breast carcinoma. Perhaps, patients with nonspecific GI symptoms should have an endoscopic examination with multiple random biopsies as invasive lobular carcinoma typically mimics macroscopic changes consistent with colitis.

  5. Sarcomatoid Carcinoma of Male Urethra with Bone and Lung Metastases Presenting as Urethral Stricture

    Directory of Open Access Journals (Sweden)

    Niraj Badhiwala

    2013-01-01

    Full Text Available A 57-year-old man who presented with urinary retention was found to have a sarcomatoid carcinoma of the urethra. Evaluation with CT scan of the abdomen and pelvis revealed multiple pulmonary nodules and osteolytic lesions of left posterior ribs. After external beam radiation therapy and six cycles of systemic chemotherapy, patient underwent a surgical resection of the urethral cancer. After his surgery, patient was also found to have multiple brain metastases and underwent whole brain radiation therapy, nine months after his initial diagnosis. Sarcomatoid carcinomas of the genitourinary tract are extremely rare tumors that require a very aggressive, multimodal treatment approach.

  6. Thyroid Duplication and Papillary Carcinoma in an Ectopic Thyroid. A Case Presentation

    Directory of Open Access Journals (Sweden)

    José Alberto Puerto Lorenzo

    2012-05-01

    Full Text Available We present the case of a patient with a palpable tumor located in midline of the anterior neck above the hyoid bone, initially diagnosed as a thyroglossal duct cyst. Preliminary study of the lesion was conducted, both clinically and radiologically and cytologically. The tumor was removed through surgery by conventional technique. The paraffin biopsy defined the existence of thyroid papillary carcinoma. Despite this condition, the patient had thyroid gland in normal location. It is considered to be a curious case, combining the concepts of thyroid duplication and ectopic thyroid, with the presence, in this last one, of papillary carcinoma.

  7. Pituitary metastasis of hepatocellular carcinoma presenting with panhypopituitarism: a case report.

    Science.gov (United States)

    Tanaka, Tomoko; Hiramatsu, Katsushi; Nosaka, Takuto; Saito, Yasushi; Naito, Tatsushi; Takahashi, Kazuto; Ofuji, Kazuya; Matsuda, Hidetaka; Ohtani, Masahiro; Nemoto, Tomoyuki; Suto, Hiroyuki; Yamamoto, Tatsuya; Kimura, Hirohiko; Nakamoto, Yasunari

    2015-11-06

    Metastasis to the pituitary gland is extremely rare and is often detected incidentally by symptoms associated with endocrine dysfunction. Breast and lung cancer are the most common primary metastasizing to pituitary gland. Metastasis from hepatocellular carcinoma to the pituitary gland is extremely rare, with only 10 cases having been previously reported. We present here the first case of pituitary metastasis of hepatocellular carcinoma presenting with panhypopituitarism diagnosed by magnetic resonance imaging. We report the case of an 80-year-old Japanese woman who presented with the sudden onset of hypotension and bradycardia after having previously been diagnosed with hepatocellular carcinoma. Based on low levels of pituitary hormones, she was diagnosed with panhypopituitarism caused by metastasis of the hepatocellular carcinoma to the pituitary gland. Magnetic resonance imaging with arterial spin-labeling was effective in the differential diagnosis of the intrasellar tumor. The patient died despite hormone replacement therapy because of hypovolemic shock. Metastasis to the pituitary gland causes various non-specific symptoms, so it is difficult to diagnose. The present case emphasizes the importance of diagnostic imaging in identifying these metastases. Clinicians should consider the possibility of pituitary metastasis in patients with malignant tumors who demonstrate hypopituitarism.

  8. Pituitary metastasis of hepatocellular carcinoma presenting with panhypopituitarism: a case report

    International Nuclear Information System (INIS)

    Tanaka, Tomoko; Hiramatsu, Katsushi; Nosaka, Takuto; Saito, Yasushi; Naito, Tatsushi; Takahashi, Kazuto; Ofuji, Kazuya; Matsuda, Hidetaka; Ohtani, Masahiro; Nemoto, Tomoyuki; Suto, Hiroyuki; Yamamoto, Tatsuya; Kimura, Hirohiko; Nakamoto, Yasunari

    2015-01-01

    Metastasis to the pituitary gland is extremely rare and is often detected incidentally by symptoms associated with endocrine dysfunction. Breast and lung cancer are the most common primary metastasizing to pituitary gland. Metastasis from hepatocellular carcinoma to the pituitary gland is extremely rare, with only 10 cases having been previously reported. We present here the first case of pituitary metastasis of hepatocellular carcinoma presenting with panhypopituitarism diagnosed by magnetic resonance imaging. We report the case of an 80-year-old Japanese woman who presented with the sudden onset of hypotension and bradycardia after having previously been diagnosed with hepatocellular carcinoma. Based on low levels of pituitary hormones, she was diagnosed with panhypopituitarism caused by metastasis of the hepatocellular carcinoma to the pituitary gland. Magnetic resonance imaging with arterial spin-labeling was effective in the differential diagnosis of the intrasellar tumor. The patient died despite hormone replacement therapy because of hypovolemic shock. Metastasis to the pituitary gland causes various non-specific symptoms, so it is difficult to diagnose. The present case emphasizes the importance of diagnostic imaging in identifying these metastases. Clinicians should consider the possibility of pituitary metastasis in patients with malignant tumors who demonstrate hypopituitarism

  9. Unusual presentation of an Amazon parrot (Amazon a species) with hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Freeman, K.P.; Hahn, K.A.; Jones, M.P.; Petersen, M.G.; Toal, R.L.

    1999-01-01

    Non-haematopoietic hepatic malignancies are uncommon in birds. The clinical presentation (i.e, chronic buphthalmos) and non-specific radiographic findings observed in this adult Amazon parrot (Amazona spp,) were not consistent with previous reports describing the natural behaviour of metastatic hepatocellular carcinoma in birds

  10. Study of hormonal status of surgical patients with endometrial carcinoma

    International Nuclear Information System (INIS)

    Musina, R.Kh.; Kiseleva, N.S.; Modnikov, O.P.

    1987-01-01

    A radioimmunoassay was conducted in the pituitary-ovary and pituitary-adrenals systems in 37 cases of endometrial carcinoma treatment and 1, 3, 5 and 14 days after extirpation of the uterus and appendages. The levels of follicle - stimulating (FSH) and luteinizing (LH) hormones of the pituitary, prolactin, ACTH, estradiol, progesterone, testosterone, cortisol and aldosterone were studied. Such disturbances as decreased production of FSH, LH, progesterone and testosterone were observed before operation. Surgery was followed by a considerable rise in prolactin production and basal levels of FSH and LH, a decrease in estradiol, progesterone and testosterone concentrations and was accompanied by a sizeable release of cortisol and aldosterone

  11. Present status of libraries processed from JENDL-3.2

    International Nuclear Information System (INIS)

    Yamano, Naoki

    1996-01-01

    Data libraries processed from JENDL-3.2 were produced by JAERI for use of typical applications in the area of nuclear reactor and shielding. These libraries had the distinction of being free of restrictions on distribution. The other data libraries for decay, activation, dosimetry, nuclide transmutation, burn-up, PKA, KERMA and DPA calculations are now being accumulated. The current status on the development of these libraries has been described. A discussion is presented about how to disseminate and share the products of JNDC activities. (author)

  12. Overview of mycotoxin methods, present status and future needs.

    Science.gov (United States)

    Gilbert, J

    1999-01-01

    This article reviews current requirements for the analysis for mycotoxins in foods and identifies legislative as well as other factors that are driving development and validation of new methods. New regulatory limits for mycotoxins and analytical quality assurance requirements for laboratories to only use validated methods are seen as major factors driving developments. Three major classes of methods are identified which serve different purposes and can be categorized as screening, official and research. In each case the present status and future needs are assessed. In addition to an overview of trends in analytical methods, some other areas of analytical quality assurance such as participation in proficiency testing and reference materials are identified.

  13. Present status and plans of JENDL FP data evaluation project

    International Nuclear Information System (INIS)

    Kawano, Toshihiko

    2003-01-01

    The Fission Product (FP) data evaluation is one of the key issues for the next revision of JENDL, since many data were carried over from JENDL-3.2 to 3.3. The new FP Working Group (FPWG) was organized in the Japanese Nuclear Data Committee (JNDC) to perform new evaluations of FP data for JENDL. In the present review of FP data evaluation, we show the history and current status of FP nuclear data, requirements of FP data, new measurements, the international cooperation, and the future plans toward the new JENDL. (author)

  14. Present status and issues for accelerator driven transmutation system

    International Nuclear Information System (INIS)

    Mizumoto, Motoharu

    2003-01-01

    Proper treatment of high-level nuclear wastes (HLW) that are produced in operation of nuclear power plants is one of the most important problems for further utilization of nuclear energy. The purpose of the accelerator driven nuclear waste transmutation system (ADS) is to transmute these nuclei to stable or short-lived nuclei by various radiation-induced nuclear reactions. When ADS for HLW can be realized, burden to deep geological disposal can be considerably reduced. In the paper, present status and issues for ADS will be discussed. (author)

  15. Radwaste management in the UK - present status and future plans

    International Nuclear Information System (INIS)

    Eyre, B.

    1991-01-01

    In 1976, the Royal Commission on Environmental Pollution, chaired by Lord Flowers, undertook a thorough review of the status of radioactive waste management in the United Kingdom (UK). Its report became the stimulus which launched a new programme of strategic and technical work to establish a total system plan for the processing, storage, transport and disposal of all radioactive wastes in the UK. This article, which describes the evolution of the programme, is the basis of the presentation to the Korean nuclear industry earlier this year by the Deputy Chairman and Chief Executive of AEA Technology. (author)

  16. Present status of nuclear education and training in Japan

    International Nuclear Information System (INIS)

    Kiyose, R.; Sumita, K.; Moriya, F.

    1994-01-01

    In Japan, where about 30% of electricity is supplied by nuclear actives require a good number of able and ambitious young scientists and engineers especially in the future. On the other hand, almost all Japanese electric power companies, which operate nuclear power plants, are striving to keep expertise of reactor operators as high as possible. Present status in Japan of education at universities, research and training reactors, training courses at governmental institutions and nonprofit organizations, and operator training centers of electric power companies, are reviewed. 3 tabs

  17. Workshop summary of 'nuclear knowledge management: Present status and perspective'

    International Nuclear Information System (INIS)

    Yonezawa, Minoru

    2007-03-01

    The workshop on 'Nuclear Knowledge Management (NKM): Present Status and Perspective' was held at the Tokyo Institute of Technology (supported by the Japan Atomic Energy Agency), Tokyo, Japan on the 14th and 15th of December 2006. The purpose of the workshop is to introduce NKM activities inside and outside Japan so that concerned parties/professionals could share related information and enhance awareness of the issues on NKM. Participants from various sectors, such as authorities, industry, universities/research institutes, etc, made presentations. Issues on NKM are recognized and discussed. The workshop consisted of 18 oral lectures and a panel discussion. The 55 participants attended the workshop. Under permission of the Tokyo Institute of Technology which is the sponsor of the workshop, this report compiles these lecture's presentation materials which got permission of a lecturer and synopses which were submitted after the workshop. (author)

  18. Present status of the European Community's Fusion Materials Programme

    International Nuclear Information System (INIS)

    Nihoul, J.; Boutard, J.L.

    1990-01-01

    The Fusion Materials Programme of the European Communities is largely focused on the next step in the European strategy towards fusion energy development, i.e. on NET, the Next European Torus. The main objectives and operating conditions of NET are therefore first briefly presented. A review is then given of the present status of our knowledge regarding the main metallic structural materials envisaged for the first wall/blanket and for the divertor plates. Attention is paid to the need for longer term research and development towards low activation structural materials to be used in a post-NET Demonstration Reactor. Finally, a survey is presented of the current European Fusion Technology Programme devoted to the various candidate structural and protection materials for fusion devices. (author)

  19. Hypopituitarism as the presenting feature of bronchogenic carcinoma with metastases to the pituitary gland

    Directory of Open Access Journals (Sweden)

    Philip C Johnston

    2013-01-01

    Full Text Available Tumours metastasizing to the pituitary gland are uncommon. Symptomatic patients with pituitary metastases can present with diabetes insipidus, headache, visual field defects and/or anterior pituitary hormonal dysfunction. Treatment options for pituitary metastases include, surgical resection, cranial or parasellar irradiation and/or chemotherapy, and hormonal replacement if indicated. The overall prognosis of pituitary metastases is poor. We present a case of hypopituitarism as the presenting feature of bronchogenic carcinoma with metastases to the pituitary gland.

  20. Multiple Primary Merkel Cell Carcinomas Presenting as Pruritic, Painful Lower Leg Tumors

    OpenAIRE

    Laura Blumenthal; Timothy VandenBoom; Edward Melian; Anthony Peterson; Kelli A. Hutchens

    2015-01-01

    Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine tumor of the skin which almost exclusively presents as a solitary tumor. It is most often seen on sun-exposed regions, historically almost exclusively on the head and neck, with only rare case reports on the extremities. Although recent studies have shown increased incidence with up to 20% on the extremities, here we present one of these rare emerging presentations, with the addition of a unique treatment option. Our p...

  1. VGKC antibodies in pediatric encephalitis presenting with status epilepticus.

    Science.gov (United States)

    Suleiman, J; Brenner, T; Gill, D; Brilot, F; Antony, J; Vincent, A; Lang, B; Dale, R C

    2011-04-05

    Voltage-gated potassium channel antibodies (VGKC Ab) are associated with limbic encephalitis and neuromyotonia in adults. There have been no systematic investigations in children to date. We looked for antibodies that are associated with CNS syndromes in adults including antibodies to VGKCs, NMDARs, glutamic acid decarboxylase (GAD), and glycine receptor (GlyR) in the stored acute serum from 10 children with unexplained encephalitis presenting with encephalopathy and status epilepticus. We also looked for antibodies to leucine-rich glioma-inactivated 1 (Lgi1) and contactin-associated protein-like 2 (Caspr2), which are now known to be tightly complexed with VGKCs in vivo. Sixty-nine pediatric controls were used for comparison. An elevated VGKC Ab (>100 pM) was detected in 4/10 patients with encephalitis compared to only 1/69 controls (p VGKC Ab-positive patients with encephalitis was variable including good recovery (n = 1), cognitive impairment (n = 3), temporal lobe epilepsy (n = 2), and mesial temporal sclerosis (n = 1). No other antibodies were detected, including those to Lgi1 and Caspr2. Encephalitis associated with VGKC Ab occurs in children and presents with status epilepticus and focal epilepsy. These antibodies are not directed against Lgi1 or Caspr2.

  2. Large Cell Neuroendocrine Carcinoma of the Rectum Presenting with Extensive Metastatic Disease

    Directory of Open Access Journals (Sweden)

    Vinay Minocha

    2014-01-01

    Full Text Available Introduction. Rectal large cell neuroendocrine carcinoma (LCNEC is a poorly differentiated neoplasm that is very rare and belongs within the poorest prognostic subgroup among primary colorectal neoplasms. Here, we describe a case of LCNEC of the rectum, which highlights the aggressive clinical course and poor prognosis associated with this disease. Case Presentation. We report a case of a 63-year-old male who presented to our hospital with a one-month history of lower abdominal pain, constipation, and weight loss. A computed tomography (CT scan of the chest, abdomen, and pelvis revealed a rectal mass as well as metastatic disease of the liver and lung. Flexible sigmoidoscopy revealed a fungating, ulcerated and partially obstructing rectal mass located 6 cm from the anal verge. This mass was biopsied and pathological examination of the resected specimen revealed features consistent with a large cell neuroendocrine carcinoma. Conclusion. Rectal large cell neuroendocrine carcinomas are rare and have a significantly worse prognosis than adenocarcinomas. At diagnosis, a higher stage and metastatic disease are likely to be found. It is important to differentiate large cell, poorly differentiated neuroendocrine carcinomas from adenocarcinomas of the colon and rectum pathologically because patients may benefit from alternative cytotoxic chemotherapeutic regimens.

  3. Present status of laser technology for maintenance and repair

    International Nuclear Information System (INIS)

    Sano, Yuji

    2001-01-01

    A laser has superior spatial and timely controllability and has no repulsive force at its use, it is a tool suitable for remote operation. And, as a partial processing with low exotherm and deformation by its use becomes possible, it can have an advantage omissible for post processes such as heat treatment and so on. Therefore, on in-situ repair of present constructions, laser is thought to be an optimum tool. And, in nuclear energy plants, maintenance and management of their instruments are important, and then a number of technical developments activating its advantages have been carried out. Above all, repair engineering around a reactor has a number of places difficult to access them for its operators, so remote engineering using laser is desired for in special. Here was described on the present status of development and realization containing protect conservation and inspection repair technology using laser. (G.K.)

  4. The simulation for the ATLAS experiment Present status and outlook

    CERN Document Server

    Rimoldi, A; Gallas, M; Nairz, A; Boudreau, J; Tsulaia, V; Costanzo, D

    2004-01-01

    The simulation program for the ATLAS experiment is presently operational in a full OO environment. This important physics application has been successfully integrated into ATLAS's common analysis framework, ATHENA. In the last year, following a well stated strategy of transition from a GEANT3 to a GEANT4-based simulation, a careful validation programme confirmed the reliability, performance and robustness of this new tool, as well as its consistency with the results of previous simulation. Generation, simulation and digitization steps on different sets of full physics events we retested for performance. The same software used to simulate the full the ATLAS detector is also used with testbeam configurations. Comparisons to real data in the testbeam validate both the detector description and the physics processes within each subcomponent. In this paper we present the current status of ATLAS GEANT4 simulation, describe the functionality tests performed during its validation phase, and the experience with distrib...

  5. Present status of fuel motion detection by radiation

    International Nuclear Information System (INIS)

    Sumita, Kenji; Mizuta, Hiroshi; Ishizuka, Makoto; Ara, Katsuyuki; Nakata, Hirokatsu.

    1978-05-01

    In reactor safety research, it is important to know transient fuel behavior under accidental conditions. Transient histories such as temperature and axial expansion of fuel and cladding and internal pressure of fuel rod are thus measured in experiments simulating accidents. If fuel motion could then be observed during and after fuel failure, this would greatly make for fuel behavior research. The present status is reviewed of fuel motion detections by radiations such as neutron, γ-ray and X-ray, including the principle and system. A neutron hodoscope among them is used already with practical results in in-reactor safety experiments of sodium-cooled fast breeder reactor. So, this is described in detail and its conceptual design as applied to the NSRR is presented. (auth.)

  6. The present status of xeroderma pigmentosum in Japan and a tentative severity classification scale.

    Science.gov (United States)

    Nakano, Eiji; Masaki, Taro; Kanda, Fumio; Ono, Ryusuke; Takeuchi, Seiji; Moriwaki, Shinichi; Nishigori, Chikako

    2016-08-01

    Xeroderma pigmentosum (XP) is a rare autosomal recessive hereditary disease. Patients with XP have severe hypersensitivity to sunlight, resulting in skin cancers, and some patients have neurological symptoms. In Japan, XP complementation group A (XP-A) is the most common form, and it is associated with severe neurological symptoms. We performed a nationwide survey on XP to determine the present status of XP in Japan. The distribution of complementation groups in Japan was considerably different from that in other countries, but there was a higher frequency in group A and the variant type, which is similar to previous reports in Japan. Basal cell carcinoma was the most frequent skin cancer that patients with XP developed, followed by squamous cell carcinoma and malignant melanoma. The frequency of these skin cancers in patients with XP-A has decreased, and these skin cancers have been occurring in much older people than those previously observed. Diagnosing XP in patients at younger ages seems to encourage patients and their parents to use sun protection, which helps prevent skin cancer. We also created a tentative scale for classifying the severity of XP, and we evaluated the neurological symptoms of XP-A using this severity scale. Our classification correlated well with patients' age, suggesting that it may be useful and feasible in clinical practice to assess the progression of symptoms of each patient with XP and evaluate the effects of treatment in the future. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Immunotherapy for Urothelial Carcinoma: Current Status and Perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Kitamura, Hiroshi, E-mail: hkitamu@sapmed.ac.jp; Tsukamoto, Taiji [Department of Urology, Sapporo Medical University School of Medicine, South 1 West 16, Chuo-ku, Sapporo 060-8543 (Japan)

    2011-07-29

    Intravesical instillation of bacillus Calmette Guérin (BCG) for the treatment of urothelial carcinoma (UC) of the bladder is based on the BCG-induced immune response, which eradicates and prevents bladder cancer. The results of recent studies have suggested that not only major histocompatibility complex (MHC)-nonrestricted immune cells such as natural killer cells, macrophages, neutrophils, etc., but also MHC-restricted CD8{sup +} T cells play an important role and are one of the main effectors in this therapy. Better understanding of the mechanism of BCG immunotherapy supports the idea that active immunotherapy through its augmented T cell response can have great potential for the treatment of advanced UC. In this review, progress in immunotherapy for UC is discussed based on data from basic, translational and clinical studies. We also review the escape mechanism of cancer cells from the immune system, and down-regulation of MHC class I molecules.

  8. Immunotherapy for Urothelial Carcinoma: Current Status and Perspectives

    International Nuclear Information System (INIS)

    Kitamura, Hiroshi; Tsukamoto, Taiji

    2011-01-01

    Intravesical instillation of bacillus Calmette Guérin (BCG) for the treatment of urothelial carcinoma (UC) of the bladder is based on the BCG-induced immune response, which eradicates and prevents bladder cancer. The results of recent studies have suggested that not only major histocompatibility complex (MHC)-nonrestricted immune cells such as natural killer cells, macrophages, neutrophils, etc., but also MHC-restricted CD8 + T cells play an important role and are one of the main effectors in this therapy. Better understanding of the mechanism of BCG immunotherapy supports the idea that active immunotherapy through its augmented T cell response can have great potential for the treatment of advanced UC. In this review, progress in immunotherapy for UC is discussed based on data from basic, translational and clinical studies. We also review the escape mechanism of cancer cells from the immune system, and down-regulation of MHC class I molecules

  9. Stroke due to non-bacterial thrombotic endocarditis as initial presentation of breast invasive ductal carcinoma.

    Science.gov (United States)

    Detremerie, Celine; Timmermans, Frank; De Pauw, Michel; Gheeraert, Peter; Hemelsoet, Dimitri; Toeback, Jonas; Bové, Thierry; Vandecasteele, Els

    2017-08-01

    We present a case of a 71-year-old woman with recurrent stroke episodes due to non-bacterial thrombotic endocarditis (NBTE) leading to the diagnosis of an early-stage breast carcinoma. NBTE is associated with a variety of inflammatory states, including malignancy. NBTE presents itself with systemic embolization, mostly stroke. Treatment consists of treating the underlying condition and start of systemic anticoagulation therapy. Cardiac surgery is restricted to highly selected cases, since prognosis usually is limited by the neoplasm, which usually is in an advanced stage at time of diagnosis of NBTE. The malignancy usually is diagnosed prior to NBTE. Cases presenting with NBTE leading to the diagnosis of malignancy, however, are rarely reported. To our knowledge, we present the first case leading to the diagnosis of an early-stage breast carcinoma.

  10. Nasopharyngeal carcinoma with secondaries at the porta hepatis presenting as obstructive jaundice.

    Science.gov (United States)

    Elango, S; Jayakumar, C R

    1990-01-01

    Recent reports have dispelled the previously held concept that head and neck cancer rarely metastases beyond the cervical lymph nodes. Nasopharyngeal cancer has been reported to have a higher incidence of distant metastases compared to other head and neck cancers, the common sites being bone, lung and liver. A case of nasopharyngeal carcinoma presenting as obstructive jaundice because of secondaries at the porta hepatis is presented here.

  11. The Present Status of Nuclear Medicine in Korea

    International Nuclear Information System (INIS)

    Lee, Mun Ho

    1968-01-01

    It is my privilege to give you a brief history on the status of nuclear medicine in Korea. There is nothing much to mention, as the history of the peaceful use of atomic energy is rather short and the RI facilities are limited in the number. It is my sincere hope, however, that you may understand what steps nuclear medicine in the developing countries did take and how it has been developed, seeing the present status of nuclear medicine in Korea, as one of the models. In our country, the peaceful use of atomic energy was actualized since the Law of Atomic Energy had been enacted in March 1959, and the Office of Atomic Energy and the Atomic Energy Research Institute had been established. The Korea Society of Nuclear Medicine was organized in 1961, which i think is one of the older in the Far East area. The Society now held about 170 members and the annual meetings in addition to the quarterly meeting have been held. The 6th general scientific meeting for 1967 is scheduled to be held in 25 November. The society publishes the Korean Journal of Nuclear Medicine twice a year, and the second issue appeared Oct. 1967. The instruments used in nuclear medicine are mostly expensive, therefore, the hospitals equipped with such instruments are inevitably limited in number and the after-service or repair of such instruments are technically not easy. Some of these difficulties, i hope, shall be overcome in the near future.

  12. Mucoepidermoid carcinoma of the lung with initial presentation of microangiopathic hemolytic anemia and thrombocytopenia

    Directory of Open Access Journals (Sweden)

    Yuan-Chun Huang

    2017-12-01

    Full Text Available Mucoepidermoid carcinoma is a rare entity of lung malignancy that is subclassified into high-grade or low-grade types according to its histological features. High-grade mucoepidermoid carcinoma is a more aggressive form of malignancy, with a tendency towards lymph node involvement and distant metastasis. Cancer-related microangiopathic hemolytic anemia as a less common situation of paraneoplastic syndrome may be encountered with metastatic malignancy, but has not been reported previously in mucoepidermoid carcinoma of the lung. Herein, we report a 78-year-old male patient who presented with hemoptysis for one day. Laboratory tests showed microangiopathic hemolytic anemia and thrombocytopenia. A chest X-ray demonstrated consolidation in the left lung field. Chest computed tomography revealed a mass in the left upper lobe, and a subsequent bronchoscopic biopsy was performed. The histopathological results indicated a high-grade mucoepidermoid carcinoma. Magnetic resonance imaging of the brain demonstrated leptomeningeal carcinomatosis. The patient refused systemic chemotherapy, and palliative radiation therapy only was conducted for local disease control. The patient has performed well for 12 months to date since diagnosis of the tumor.

  13. Diffuse sclerosing variant of thyroid carcinoma presenting as Hashimoto thyroiditis: a case report.

    Science.gov (United States)

    Vukasović, Anamarija; Kuna, Sanja Kusacić; Ostović, Karmen Trutin; Prgomet, Drago; Banek, Tomislav

    2012-11-01

    The aim of report is to present a case of a rare diffuse sclerosing variant of a papillary thyroid carcinoma. A 15-year old girl referred for ultrasound examination because of painless thyroid swelling lasting 10 days before. An ultrasound of the neck showed diffusely changed thyroid parenchyma, without nodes, looking as lymphocytic thyroiditis Hashimoto at first, but with snow-storm appearance, predominantly in the right lobe. Positive thyroid peroxidase antibodies (TPO-AT) also suggested Hashimoto thyroiditis. Repeated US-FNAB (fine needle-aspiration biopsy) of the right lobe revealed diffuse sclerosing variant of papillary thyroid carcinoma and patient underwent total thyreoidectomy. Patohistologic finding confirmed diffuse sclerosing variant of a papillary thyroid carcinoma in the both thyroid lobes and several metastatic lymph nodes. Two months later patient recived radioablative therapy with 3700 MBq (100 mCi) of 1-131 followed by levothyroxine replacement. At the moment, patient is without evidence of local or distant metastases and next regular control is scheduled in 6 months. In conclusion, a diffuse sclerosing variant is rare form of papillary thyroid carcinoma that echographically looks similar to Hashimoto thyroiditis and sometimes could be easily overlooked.

  14. Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsis.

    Science.gov (United States)

    Damin, Andrea Pires; Nascimento, Fernanda Costa; Andreola, João Batista; Cerutti, Talita Haubert; Roehe, Adriana; Damin, Daniel Carvalho

    2011-12-01

    Squamous cell carcinoma (SCC) of the breast is an extremely rare form of cancer, accounting for approximately 0.04% of all malignant breast tumors. To date, only a limited number of cases of SCC of the breast have been reported, and most of them presented like the usual breast carcinomas. A 39-year-old woman presented with a large breast abscess and signs of sepsis. After surgical debridement of the lesion, histopathological examination of the abscess capsule revealed the presence of SCC of the breast. The definitive treatment for the tumor consisted of modified radical mastectomy with resection of the residual lesion in the right breast. This unusual case illustrates how an apparently benign disorder such as a breast abscess might be related to a clinically occult malignancy. A review of the literature on SCC of the breast is presented.

  15. Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsis

    Directory of Open Access Journals (Sweden)

    Andrea Pires Damin

    Full Text Available CONTEXT: Squamous cell carcinoma (SCC of the breast is an extremely rare form of cancer, accounting for approximately 0.04% of all malignant breast tumors. To date, only a limited number of cases of SCC of the breast have been reported, and most of them presented like the usual breast carcinomas. CASE REPORT: A 39-year-old woman presented with a large breast abscess and signs of sepsis. After surgical debridement of the lesion, histopathological examination of the abscess capsule revealed the presence of SCC of the breast. The definitive treatment for the tumor consisted of modified radical mastectomy with resection of the residual lesion in the right breast. CONCLUSIONS: This unusual case illustrates how an apparently benign disorder such as a breast abscess might be related to a clinically occult malignancy. A review of the literature on SCC of the breast is presented

  16. Lymphoepithelioma-like carcinoma of the breast presenting as breast abscess.

    Science.gov (United States)

    Suzuki, Ikumi; Chakkabat, Pimchandr; Goicochea, Lindsay; Campassi, Cristina; Chumsri, Saranya

    2014-12-10

    Lymphoepithelioma-like carcinoma (LELC) is a rare type of neoplasm in which only twenty cases have been reported in the breast. This type of tumor can be difficult to distinguish from other breast tumors particularly medullary carcinoma and lymphoma in the breast. We present a case of LELC of the breast presenting as an abscess along with a review of the literature. This is the 21(st) reported case of LELC of the breast and the first case to present as an abscess. Her clinical picture could have been mistaken for other infectious or inflammatory diseases. Given the potential for favorable outcome, early detection and general knowledge of this neoplasm are essential to expedite treatment for this rare tumor type.

  17. Cervical Lymph Node Metastasis: Unusual Presentation of Adenoid Cystic Carcinoma - Diagnosed By FNAC

    Directory of Open Access Journals (Sweden)

    Archana Buch

    2015-01-01

    Full Text Available Adenoid cystic carcinoma (ACC is a rare neoplasm that usually arises from minor salivary glands. It is characteristically locally infiltrative, exhibiting perineural invasion, has a tendency for local recurrence and prolonged clinical course. A 60 year old male, chronic smoker presented with swelling of the left cervical lymph node since two months. Examination revealed a solitary firm, non tender, non mobile left cervical swelling measuring 2 x 1 cm. Fine Needle Aspiration Cytology (FNAC was done from the cervical lymph node. The diagnosis of metastatic deposits of ACC was given. Detail examination of the oral cavity revealed a small swelling at the floor of the mouth. Biopsy of the swelling confirmed ACC on histopathological examination. An unusual feature of adenoid cystic carcinoma is the low incidence of metastases to regional lymph nodes. The case is presented to highlight its unusual presentation and utility of FNAC in rapid diagnosis.

  18. The ACES mission: scientific objectives and present status

    Science.gov (United States)

    Cacciapuoti, L.; Dimarcq, N.; Salomon, C.

    2017-11-01

    "Atomic Clock Ensemble in Space" (ACES) is a mission in fundamental physics that will operate a new generation of atomic clocks in the microgravity environment of the International Space Station (ISS). The ACES clock signal will combine the medium term frequency stability of a space hydrogen maser (SHM) and the long term stability and accuracy of a frequency standard based on cold cesium atoms (PHARAO). Fractional frequency stability and accuracy of few parts in 1016 will be achieved. The on-board time base distributed on Earth via a microwave link (MWL) will be used to test fundamental laws of physics (Einstein's theories of Special and General Relativity, Standard Model Extension, string theories…) and to develop applications in time and frequency metrology, universal time scales, global positioning and navigation, geodesy and gravimetry. After a general overview on the mission concept and its scientific objectives, the present status of ACES instruments and sub-systems will be discussed.

  19. Present status of the ion ring compressor approach to fusion

    International Nuclear Information System (INIS)

    Fleischmann, H.H.

    1975-01-01

    A short review is given of the present research status with regard to the Ion Ring Compressor. A consideration of the reactor characteristics of this fusion scheme indicates the potential for a number of technologically and economically interesting features, in particular with respect to the high-confinement characteristics expected for such minimum-B configurations. Experimental results from the RECE-program at Cornell indicate generally good gross stability of strong electron rings, including purely collisional decay, stability against field perturbations and others. Most-recent experiments have extended the ring lifetime to more than 2 x 10 5 electron orbits. Strong electron rings have been shifted over an axial distance of up to 30 cm. Experiments with magnetic-field insulated diodes indicate ion pulses of up to 300 nsec, and field insulation of up to 800 nsec when metallic electrodes are used

  20. The present status of the Telescope Array experiment

    Energy Technology Data Exchange (ETDEWEB)

    Nonaka, T. [Institute for Cosmic Ray Research University of Tokyo, 5-1-5 Kashiwanoha Kashiwa Chiba (Japan); Abu-Zayyad, T.; Allen, M. [University of Utah - High Energy Astrophysics Institute, 115 S 1400 E 201, Salt Lake City, UT 84112-0830 (United States); Azuma, R. [Tokyo Institute of Technology, 2-12-1 Ohokayama Meguro-ku, Tokyo 152-8550 (Japan); Belz, J.W. [University of Utah - High Energy Astrophysics Institute, 115 S 1400 E 201, Salt Lake City, UT 84112-0830 (United States); Bergman, D.R. [Rutgers University, 136 Frelinghuysen Road, Piscataway, NJ 08854 (United States); Blake, S.A.; Brusova, O.; Cady, R.; Cao, Z. [University of Utah - High Energy Astrophysics Institute, 115 S 1400 E 201, Salt Lake City, UT 84112-0830 (United States); Chiba, J. [Tokyo University of Science, 2641 Yamazaki Noda-shi, Chiba 278-8510 (Japan); Chikawa, M. [Kinki University, 3-4-1 Kowakae, Higashiosaka-shi, Osaka 577-8582 (Japan); Cho, I.S. [Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul (Korea, Republic of); Fujii, H. [KEK - Institute of Particle And Nuclear Studies, 1-1 Oho Tsukuba-shi, Ibaraki 305-0801 (Japan); Fujii, T. [Osaka City University, 3-3-138 Sugimoto-cho, Sumiyoshi-ku, Osaka 558-8585 (Japan); Fukuda, T. [Tokyo Institute of Technology, 2-12-1 Ohokayama Meguro-ku, Tokyo 152-8550 (Japan); Fukushima, M. [Institute for Cosmic Ray Research University of Tokyo, 5-1-5 Kashiwanoha Kashiwa Chiba (Japan); Hayashi, K. [Tokyo Institute of Technology, 2-12-1 Ohokayama Meguro-ku, Tokyo 152-8550 (Japan); Hayashida, N. [Institute for Cosmic Ray Research University of Tokyo, 5-1-5 Kashiwanoha Kashiwa Chiba (Japan); Hibino, K. [Kanagawa University, 3-27-1 Rokkakubashi Kanagawa-ku, Yokohama-shi, Kanagawa 221-8686 (Japan)

    2009-05-15

    The Telescope Array(TA) experiment located at western desert in Utah USA (N39.3,W112.9) is designed for observation of air shower from extreme high energy cosmic rays. The TA detector consists of 2 types of detector to enable a cross check on systematic difference from the two main methods of observation for the energy region. One is a Fluorescence detector (FD) for detecting fluorescence light from air shower and another is surface detector (SD) array for detecting air shower particles at ground level. Each SD consists of 2 layers of plastic scintillator with 3m{sup 2} of surface and more sensitive to electromagnetic component in air shower. The full operation using 3FD stations and full SD array has started. Here we present the updated status of Telescope Array experiment.

  1. Opencast coal mining in India: present status and future trends

    Energy Technology Data Exchange (ETDEWEB)

    Khare, B.P. [Kakatiya University, Warangal (India)

    2007-07-01

    This paper discussed the opencast coal mining in India, present status and future trends including technology trends. The opencast coal mines in the coming years will have to switch over more and more to semi continuous and continuous mining. Whatever be the system adopted it should be sustainable to meet the output levels commensurate with environmental protection, safety, health, conservation and economics. It could, therefore, be summed up that the search for new technologies should be based on: (1) use of continuous miners; (2) use of bucket wheel excavators, conveyors, and spreaders; (3) shovel-crusher and conveyor system; and (4) application of high angle conveyors, cross-pit conveyors, and OB bridges. 4 tabs.

  2. Present status of uranium resource development in foreign countries, 1984

    International Nuclear Information System (INIS)

    1984-12-01

    The book of the same title as this one was published in 1983. Since then, the situation requiring the correction of the contents, such as the correction of uranium resource policy in various countries accompanying the change of uranium market condition and the change of uranium policy in Australia due to the political situation, has occurred, consequently, the revision has been made adding these new information. The confirmed resources of uranium and the resources of uranium to be added by estimation in the free world are tabulated. About each country, the organization and policy, the policy of exporting uranium and the present status of the export, the quantity of uranium resources, the production of uranium, the state of exploration and development and so on are reported. Japan has taken part in the development of uranium resources in Australia, Canada, Gabon, Zambia, Morocco, Guinea, Mali and so on. (Kako, I.)

  3. Survey on present status and trend of parallel programming environments

    International Nuclear Information System (INIS)

    Takemiya, Hiroshi; Higuchi, Kenji; Honma, Ichiro; Ohta, Hirofumi; Kawasaki, Takuji; Imamura, Toshiyuki; Koide, Hiroshi; Akimoto, Masayuki.

    1997-03-01

    This report intends to provide useful information on software tools for parallel programming through the survey on parallel programming environments of the following six parallel computers, Fujitsu VPP300/500, NEC SX-4, Hitachi SR2201, Cray T94, IBM SP, and Intel Paragon, all of which are installed at Japan Atomic Energy Research Institute (JAERI), moreover, the present status of R and D's on parallel softwares of parallel languages, compilers, debuggers, performance evaluation tools, and integrated tools is reported. This survey has been made as a part of our project of developing a basic software for parallel programming environment, which is designed on the concept of STA (Seamless Thinking Aid to programmers). (author)

  4. Present status of the JT-60 control system

    International Nuclear Information System (INIS)

    Kimura, T.

    1992-01-01

    The present status of the control system for a large fusion device of the JT-60 upgrade tokamak is reported including its original design concept, the progress of the system in the past five-year operation and modification for the upgrade. The control system has the features of hierarchical structure, computer control, adoption of CAMAC interfaces and protective interlock by both software and hard-wired systems. Plant monitoring and control are performed by an efficient data communication via CAMAC highways. Sequential discharge control of is executed by a combination of computers and a timing system. A plasma feedback control system with fast 32-bit microprocessors and a man/machine interface with modern workstations have been newly developed for the operation of the JT-60 upgrade. (author)

  5. Present status of controversies regarding the thermal Casimir force

    International Nuclear Information System (INIS)

    Mostepanenko, V M; Bezerra, V B; Decca, R S; Geyer, B; Fischbach, E; Klimchitskaya, G L; Krause, D E; Lopez, D; Romero, C

    2006-01-01

    It is well known that, beginning in 2000, the behaviour of the thermal correction to the Casimir force between real metals has been hotly debated. As was shown by several research groups, the Lifshitz theory, which provides the theoretical foundation for the calculation of both the van der Waals and Casimir forces, leads to different results depending on the model of metal conductivity used. To resolve these controversies, theoretical considerations based on the principles of thermodynamics and new experimental tests were invoked. We analyse the present status of the problem (in particular, the advantages and disadvantages of the approaches based on the surface impedance and on the Drude model dielectric function) using rigorous analytical calculations of the entropy of a fluctuating field. We also discuss the results of a new precise experiment on the determination of the Casimir pressure between two parallel plates by means of a micromechanical torsional oscillator

  6. Occipital condyle metastasis: an unusual clinical presentation in carcinoma of the lung

    International Nuclear Information System (INIS)

    Pasricha, R.; Mohanty, P.P.; Madan, R.C.; Datta, N.R.

    2005-01-01

    Metastases to the base of the skull and occipital condyle metastases are uncommon as a presenting feature of malignancy. Lung cancers are known for their metastatic potential to various sites, some of which could be the only presenting feature of the underlying malignancy. However, occipital condyle metastases are very rare and to the best of our knowledge, metastases to this site from carcinoma of the lung, as a presenting feature, have never been reported in the literature. The present case report describes the clinical, radiological and the therapeutic interventions that were undertaken in a patient presenting with lung cancer who had solely the features of occipital condyle metastasis

  7. Peritoneal carcinomatosis: an unusual presentation of fibrolamellar hepatocellular carcinoma; Carcinomatosis peritoneal como forma de presentacion infrecuente del hepatocarcinoma fibrolamelar

    Energy Technology Data Exchange (ETDEWEB)

    Vicente, R; Garcia-Gutierrez, J A; Fernandez, A; Santalla, F [Hospital Comarcal de la Axarquia. Malaga (Spain)

    2001-07-01

    Fibrolamellar hepatocellular carcinoma is an uncommon malignant tumor with characteristic clinical, radiological and histopahtological features that is usually associated with a more favorable natural course and greater survival than more common variants of hepatocellular carcinoma. We describe an atypical case of a fibrolamellar hepatocellular carcinomas sowing aggressive behaviour in a 20-year-old woman. The lesion presented with massive ascites, and imaging studies revealed extensive peritoneal metastatic spread. (Author) 8 refs.

  8. Current status of liver diseases in Korea: hepatocellular carcinoma.

    Science.gov (United States)

    Song, Il Han; Kim, Kyung Sik

    2009-12-01

    Primary liver cancer, most of which is hepatocellular carcinoma (HCC), is the third common leading cancer in Korea. During the last two decades, the incidence rate of primary liver cancer has shown a modest decrease, but its mortality rate has slightly increased. The incidence of HCC, according to age, peaks in the late sixth decade in men and in the early seventh decade in women. Hepatitis B virus (HBV) is the most important risk factor, which represents approximately 70% of all HCC, and hepatitis C virus (HCV) and alcohol are the next in order of major risk factors for the development of HCC in Korea. HBV-associated HCC occurs 10 years earlier than HCV-associated HCC due to a more prolonged exposure to HBV, which is vertically transmitted almost from HBsAg-positive mother in HBV-endemic area. National Cancer Control Institute, which was reorganized in 2005, is now working for several national projects such as National Cancer Registration Program, National R&D Program for Cancer Control and National Cancer Screening Program. International collaboration for the clinico-epidemiologic research would be needed to provide the specific measures for managing HCC in diverse etiologic situations. Finally, the mechanisms of hepatitis virus-associated hepatocellular carcinogenesis might be clarified to provide insights into the advanced therapeutic and preventive approaches for HCC in Korea, where the majority of HCC originate from chronic HBV and HCV infections.

  9. Overview and present status of the IAEA/RADWASS programme

    International Nuclear Information System (INIS)

    Abe, Masayoshi

    1998-01-01

    Since 1991 the International Atomic Energy Agency (IAEA) has been developing a series of safety standards documents in the field of radioactive waste management, named 'the Radioactive Waste Safety Standards (RADWASS) Programme'. The RADWASS programme is intended to establish and promote, in a coherent and comprehensive manner, the basic safety philosophy for radioactive waste management and the step necessary to ensure its implementation. And has main purposes that RADWASS publication will; (a) reflect the existing international consensus in the approaches and methodologies for a safe radioactive waste management, including disposal, and provide mechanisms to establish consensus where it does not yet exist; and (b) provide Member States with a comprehensive series of internationally agreed documents to assist in the derivation of and to complement national criteria, standards and practices. In progress, the programme was changed in 1996 its structure and documents preparation process as well as properties of RADWASS documents, the former phase was supervised by the International Radioactive Waste Management Advisory Committee (INWAC), and present phase is by the Waste Safety Standards Advisory Committee (WASSAC). Six safety series documents were published in the former programme, and several safety standards documents in the present RADWASS programme are in progress of publishing, some of them are expected to be published within several months. The overview and present status of the RADWASS programme including outline of those documents' contents already published and under the preparation are described in this report. (author)

  10. Beamlines on Indus-1 and Indus-2: present status

    International Nuclear Information System (INIS)

    Lodha, G.S.; Deb, S.K.

    2010-01-01

    Indus-1 (450 MeV) is an efficient synchrotron radiation (SR) source in the soft X-ray/vacuum ultra violet region of the electromagnetic spectrum. For Indus-1 the higher order energy contamination in soft X-ray region, heat load and radiation safety problems are also significantly low. At present five beamlines are operational. This SR source is a national science facility being used by various research group across the country. Strong efforts are underway to increase the user base of Indus-1. The talk presents some of the recent studies carried out using Indus-1. Indus-2 (2.5 GeV) synchrotron source is one of the most important accelerator based science facilities being setup in India. A few beamlines have been commissioned and are being used by researchers from different institutes. This talk gives present status of the various beamlines and experimental stations on Indus-2. It is envisaged that the atomic and molecular science community can actively participate in planning experiments on Indus-1 and Indus-2 and setup experimental stations on Indus-2. (author)

  11. Present status of the Liquid Breeder Validation Module for IFMIF

    International Nuclear Information System (INIS)

    Casal, Natalia; Mas, Avelino; Mota, Fernando; García, Ángela; Rapisarda, David; Nomen, Oriol; Arroyo, Jose Manuel; Abal, Javier; Mollá, Joaquín; Ibarra, Ángel

    2013-01-01

    Highlights: • The LBVM will be used to perform irradiation experiments on functional materials for fusion reactors. • It houses 16 experimental rigs, each one containing a EUROFER capsule partially filled with lithium lead, at 300–550 °C. • A helium purge gas will sweep the tritium permeated through the capsule walls to a tritium measuring station. • A helium cooling system will keep tritium diffusion within safe margins and guarantee its mechanical integrity. • Thermal hydraulic and mechanical calculations, the module instrumentation and aspects as safety or RAMI are presented. -- Abstract: One of the objectives of IFMIF (International Fusion Materials Irradiation Facility), as stated in its specifications, is the validation of breeder blanket concepts for DEMO design. The so-called Liquid Breeder Validation Module (LBVM) will be used in IFMIF to perform experiments under irradiation on functional materials related to liquid breeder concepts for future fusion reactors. This module, not considered in previous IFMIF design phases, is currently under design by CIEMAT in the framework of the IFMIF/EVEDA project. In this paper, the present status of the design of the LBVM is presented

  12. Present status of the Liquid Breeder Validation Module for IFMIF

    Energy Technology Data Exchange (ETDEWEB)

    Casal, Natalia, E-mail: natalia.casal@ciemat.es [Laboratorio Nacional de Fusión por Confinamiento Magnético – CIEMAT, 28040 Madrid (Spain); Mas, Avelino; Mota, Fernando; García, Ángela; Rapisarda, David [Laboratorio Nacional de Fusión por Confinamiento Magnético – CIEMAT, 28040 Madrid (Spain); Nomen, Oriol [Institut de Recerca en Energia de Catalunya (IREC), Barcelona (Spain); Centre de Disseny d’Equips Industrials (CDEI), Technical University of Catalonia (UPC), Barcelona (Spain); Arroyo, Jose Manuel [Laboratorio Nacional de Fusión por Confinamiento Magnético – CIEMAT, 28040 Madrid (Spain); Abal, Javier [Fusion Energy Engineering Laboratory (FEEL), Technical University of Catalonia (UPC) Barcelona-Tech, Barcelona (Spain); Mollá, Joaquín; Ibarra, Ángel [Laboratorio Nacional de Fusión por Confinamiento Magnético – CIEMAT, 28040 Madrid (Spain)

    2013-10-15

    Highlights: • The LBVM will be used to perform irradiation experiments on functional materials for fusion reactors. • It houses 16 experimental rigs, each one containing a EUROFER capsule partially filled with lithium lead, at 300–550 °C. • A helium purge gas will sweep the tritium permeated through the capsule walls to a tritium measuring station. • A helium cooling system will keep tritium diffusion within safe margins and guarantee its mechanical integrity. • Thermal hydraulic and mechanical calculations, the module instrumentation and aspects as safety or RAMI are presented. -- Abstract: One of the objectives of IFMIF (International Fusion Materials Irradiation Facility), as stated in its specifications, is the validation of breeder blanket concepts for DEMO design. The so-called Liquid Breeder Validation Module (LBVM) will be used in IFMIF to perform experiments under irradiation on functional materials related to liquid breeder concepts for future fusion reactors. This module, not considered in previous IFMIF design phases, is currently under design by CIEMAT in the framework of the IFMIF/EVEDA project. In this paper, the present status of the design of the LBVM is presented.

  13. An unusual co-presentation of rhinolithiasis and squamous cell carcinoma in the nasal cavity.

    Science.gov (United States)

    Özdemir, Süleyman; Görgülü, Orhan; Akbaş, Yücel; Selçuk, Tahsin; Sayar, Hamide; Tarkan, Özgür

    2012-07-01

    Rhinoliths are nasal stones that result from mineralisation of salts around an endogenous or exogenous nidus within the nasal cavity. They are uncommon nasal masses and usually unilateral and single, situated in the floor of the nose. The patient typically presents with nasal obstruction, facial pain and foul-smelling nasal secretion. To the best of our knowledge, the occurrence of squamous cell carcinoma with rhinolithiasis has not been previously reported in the English-language literature. In this article, we present a 63-year-old man, who had unilateral rhinolithiasis with squamous cell carcinoma within the nasal cavity. Copyright © 2011 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  14. Esophageal squamous cell carcinoma presenting as submucosal lesion with repeatedly negative endoscopic biopsies

    Directory of Open Access Journals (Sweden)

    Narendra S Choudhary

    2016-01-01

    Full Text Available A 74-year-old male presented with dysphagia for 2 months. Computed tomography revealed irregular wall thickening of the esophagus at T3 to T5 level. He underwent gastroscopy which revealed a submucosal bulge with normal mucosa at 25 cm from incisors. Repeated biopsies were taken, all were negative for malignancy. The patient underwent endoscopic ultrasound, and fine-needle aspiration was taken which was suggestive for squamous cell carcinoma.

  15. Transarterial ablation of hepatocellular carcinoma. Status and developments

    International Nuclear Information System (INIS)

    Radeleff, B.A.; Stampfl, U.; Sommer, C.M.; Bellemann, N.; Kauczor, H.U.; Hoffmann, K.; Ganten, T.; Ehehalt, R.

    2012-01-01

    Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and represents the main cause of death among European patients with liver cirrhosis. Only 30-40% of patients diagnosed with HCC are candidates for curative treatment options (e.g. surgical resection, liver transplantation or ablation). The remaining majority of patients must undergo local regional and palliative therapies. Transvascular ablation of HCC takes advantage of the fact that the hypervascularized HCC receives most of its blood supply from the hepatic artery. In this context transvascular ablation describes different therapy regimens which can be assigned to four groups: cTACE (conventional transarterial chemoembolization), bland embolization (transarterial embolization TAE), DEB-TACE (TACE with drug-eluting beads, DEB) and SIRT (selective internal radiation therapy, radioembolization). Conventional TACE is the most common type of transvascular ablation and represents a combination of intra-arterial chemotherapy and embolization with occlusion of the arterial blood supply. However, there is no standardized regimen with respect to the chemotherapeutic drug, the embolic agent, the usage of lipiodol and the interval between the TACE procedures. Even the exact course of a cTACE procedure (order of chemotherapy or embolization) is not standardized. It remains unclear whether or not intra-arterial chemotherapy is definitely required as bland embolization using very small, tightly calibrated spherical particles (without intra-arterial administration of a chemotherapeutic drug) shows tumor necrosis comparable to cTACE. For DEB-TACE microparticles loaded with a chemotherapeutic drug combine the advantages of cTACE and bland embolization. Thereby, a continuing chemotherapeutic effect within the tumor might cause a further increase in intratumoral cytotoxicity and at the same time a decrease in systemic toxicity. (orig.) [de

  16. Present status of FLNR (JINR) ECR ion sources

    International Nuclear Information System (INIS)

    Bogomolov, S.; Efremov, A.; Loginov, V.; Lebedev, A.; Yazvitsy, N.; Bekhterev, V.; Kostukhov, Y.; Gulbekian, G.; Gikal, B.; Drobin, V.; Seleznev, V.; Seleznev, V.

    2012-01-01

    Six ECR ion sources have been operated in the Flerov Laboratory of Nuclear Reactions (JINR). Two 14 GHz ECR ion sources (ECR4M and DECRIS-2) supply various ion species for the U400 and U400M cyclotrons correspondingly for experiments on the synthesis of heavy and exotic nuclei using ion beams of stable and radioactive isotopes. The 18 GHz DECRIS-SC ion source with superconducting magnet system produces ions from Ar up to W for solid state physics experiments and polymer membrane fabrication at the IC-100 cyclotron. The third 14 GHz ion source DECRIS-4 with 'flat' minimum of the axial magnetic field is used as a stand alone machine for test experiments and also for experiments on ion modification of materials. The other two compact ECR ion sources with all permanent magnet configuration have been developed for the production of single charged ions and are used at the DRIBs installation and at the MASHA mass-spectrometer. In this paper, present status of the ion sources, recent developments and plans for modernization are reported. The paper is followed by the slides of the presentation. (authors)

  17. Nonextensive statistical mechanics: a brief review of its present status

    Directory of Open Access Journals (Sweden)

    CONSTANTINO TSALLIS

    2002-09-01

    Full Text Available We briefly review the present status of nonextensive statistical mechanics. We focus on (i the central equations of the formalism, (ii the most recent applications in physics and other sciences, (iii the a priori determination (from microscopic dynamics of the entropic index q for two important classes of physical systems, namely low-dimensional maps (both dissipative and conservative and long-range interacting many-body hamiltonian classical systems.Revisamos sumariamente o estado presente da mecânica estatística não-extensiva. Focalizamos em (i as equacões centrais do formalismo; (ii as aplicações mais recentes na física e em outras ciências, (iii a determinação a priori (da dinâmica microscópica do índice entrópico q para duas classes importantes de sistemas físicos, a saber, mapas de baixa dimensão (tanto dissipativos quanto conservativos e sistemas clássicos hamiltonianos de muitos corpos com interações de longo alcance.

  18. Present status of inertial confinement fusion reactor design

    International Nuclear Information System (INIS)

    Mima, Kunioki; Ido, Shunji; Nakai, Sadao.

    1986-01-01

    Since inertial nuclear fusion reactors do not require high vacuum and high magnetic field, the structure of the reactor cavity becomes markedly simple as compared with tokamak type fusion reactors. In particular, since high vacuum is not necessary, liquid metals such as lithium and lead can be used for the first wall, and the damage of reactor structures by neutrons can be prevented. As for the core, the energy efficiency of lasers is not very high, accordingly it must be designed so that the pellet gain due to nuclear fusion becomes sufficiently high, and typically, the gain coefficient from 100 to 200 is necessary. In this paper, the perspective of pellet gain, the plan from the present status to the practical reactors, and the conceptual design of the practical reactors are discussed. The plan of fuel ignition, energy break-even and high gain by the implosion mode, of which the uncertain factor due to uneven irradiation and instability was limited to the minimum, was clarified. The scenario of the development of laser nuclear fusion reactors is presented, and the concept of the reactor system is shown. The various types of nuclear fusion-fission hybrid reactors are explained. As for the design of inertial fusion power reactors, the engineering characteristics of the core, the conceptual design, water fall type reactors and DD fuel reactors are discussed. (Kako, I.)

  19. The present status of the blowdown code BRUCH

    International Nuclear Information System (INIS)

    Karwat, H.

    1975-01-01

    The present status and the important features of the blowdown code for a PWR, BRUCH-D version 04 which is presently in use, are described. The code is to investigate the depressurization process, fluid dynamic situation in the core, the fuel temperature and the core mass flow as influenced by important primary system components such as steam generators, pumps etc. The code is a multinode point model with a fixed node arrangement. It makes use of the basic fluid dynamic equations describing the mass, energy and volume conservation as well as the momentum equation and the equation of state with appropriate assumptions. The core heat generation and heat transfer to the fluid is simulated by a given number of average fuel rods with up to 20 axial segmentation independent of the axial subdivision of the core fluid region. In parallel up to 5 types of the fuel rods can be studied. The pump behaviour is specified by input. For the break flow, the code provides three models; Bernoulli, homogenous and moody. The implicit-explicit method IMEX is used for the integration of the differential equations. An example for application of BRUCH-S to an experiment which is for a BWR but has some basis of BRUCH-D is also shown in the paper

  20. Present status and prospect of radiation and radioisotopes in China

    International Nuclear Information System (INIS)

    Zhou, Yong-Tian

    1986-01-01

    Production and application of radioisotopes in China started almost thirty years ago. At present there are 20 units producing more than 700 radioisotope products. This report outlines the present status and prospect of radiation and radioisotopes in some major areas. Remarkable achievements have been made in agriculture using nuclear technology. More than 70 new varieties or strains of cultivated plants have been bred by inducing mutation through irradiation. A new variety of silkworm bred by irradiation has unique characteristics such as high and stable yield. Application of radioisotopes in medical research and clinical practice began in 1956 and radionuclides have been progressively used in diagnosis and treatment of diseases. The most common radionuclide used in therapy is iodine-131 for hyperthyroidism. Isotope-tracer technique and activation analysis play an important role in the study of traditional Chinese medicine. Isotope methods in China have been used in many industrial branches, such as textile, plastic and printing, but not very widely now. The nation has produced more than 2,000 sets of nuclear radiation measuring instruments, which become important parts of industrial automation control. The radiation processing research started in the end of 1950's. Food irradiation research has been going on in a good cooperation of different branches. Now China is planning to set up some plants to produce gamma irradiated disposal syringes and other medical devices. (Nogami, K.)

  1. The CAREM project: Present status and development activities

    International Nuclear Information System (INIS)

    Boado Magan, H.J.; Ordonez, J.P.; Hey, A.

    1997-01-01

    The CAREM Project is a low power NPP of 25 Mwe, with an integrated self pressurized primary system. The cooling of the primary system is of the natural circulation type and several passive safety systems are included. The owner of the Project is Argentina's CNEA (Comision Nacional de Energia Atomica) and its associated company, INVAP, is the main contractor. The present status of the CAREM Project is presented. The possible evolution of the CAREM project is mentioned in relation with a new containment design. A short description of the Experimental Facilities, listed below, already in operation and under construction are also included: CAPCN High Pressure Loop. Natural convection loop to verify dynamic response and critical heat flux; RA-8. Critical Facility, designed and constructed for the CAREM Project (that may be used as a general uses facility); RPV lnternals. The whole assembly of absorbent rods, connecting rods and the rode guides are being constructed in a 1:1 scale. The aims of this experimental facility are vibration analysis and manufacturing parameters definitions. Control Drive Mechanisms. A series of verification and tests are being carried out on these within RPV Hydraulically driven mechanisms. Other development activities are mentioned in relation with the thermalhydraulics, Steam Generators and Control. (author)

  2. Evaluation of oxidative stress status and antioxidant capacity in patients with renal cell carcinoma

    OpenAIRE

    Aldemir, Mustafa; Karaguzel, Ersagun; Okulu, Emrah; Gudeloglu, Ahmet; Ener, Kemal; Ozayar, Asim; Erel, Ozcan

    2015-01-01

    Introduction We evaluated and compared the serum oxidative stress and antioxidant enzymes in patients with renal cell carcinoma (RCC) and the control group. Material and methods The prospective study consisted of 97 patients with RCC (Group 1) and 80 age and sex matched healthy volunteers (Group 2). Group 1 and 2 were compared concerning serum mean total oxidant status (TOS), total antioxidant capacity (TAC), paraoxonase-1 (PON-1), arylesterase, total thiol, catalase (CAT), myeloperoxidase (M...

  3. Radiation education in Poland. The present status and perspectives

    International Nuclear Information System (INIS)

    Goraczko, W.

    1999-01-01

    The necessity for the continued education about radiation (both in nuclear science and the technical application of radioisotopes) in the educational systems is obvious. For many years this subject has been part of a students education in physics as well as nonphysical areas of study, such as chemistry, biology, medicine, ecology and agriculture. Unfortunately in the wake of the disaster at Chernobyl, a number of negative factors have resulted that have undermined both educations in this crucial area and financial investment in Polish radiation institutes. Some sociologists have termed this behavior/viewpoint 'radio-phobia phenomena'. Might I be so bold as to recoin it as 'nuclear related paranoia' since it has caused a general breakdown in rational, 'cause and effect analysis' even within respectable scientific circles, including prominent radio biologists, who now accept radiation only as a destructive factor in biological and human life. The most important factor in this campaign will be the promotion and presentation of radiation in simple-understandable terms through the following outlets, (popular articles, TV programs, objective classroom presentation and so on), designed to be easily understandable to society as a whole. In this support is to be found in some governmental and independent organization, which do attempt to show radiation as bio-positive, human friendly and an economically indispensable factor for the future. However our fight with the so-called coal lobby' will continue to be difficult. Help by international organizations such as the I.A.E.A. will not suffice in this battle. In this article the author tries to describe the Polish education system and statistical data showing the present status of radiation science, radiation education and the quantity of students and experts in the field. As a nuclear physicist and specialist in radiation protection, lecturer and an Inspector of Radiation Protection, he provides insights from his own

  4. Metastatic hepatocellular carcinoma in the maxilla and mandible, an extremely rare presentation

    Directory of Open Access Journals (Sweden)

    Satya Ranjan Misra

    2015-01-01

    Full Text Available Malignancy is characterized by anaplasia, invasiveness, and metastasis. Primary oral squamous cell carcinoma is the most prevalent oral malignancy, but secondary malignancy from distant sites have also been reported. Hepatocellular carcinoma (HCC is a common primary liver malignancy that frequently metastasizes during the course of the disease, but < 1% of cases show oral involvement. Such secondary neoplasms do not have any pathognomonic clinical or radiologic findings, and therefore they pose a diagnostic challenge. Hence, in the differential diagnosis of malignant tumors of the oral cavity, it is essential to consider the occurrence of both primary as well as metastatic tumors despite the low incidence of the latter. A rare case of HCC metastasizing to both the maxilla and mandible is presented, in which the patient succumbed to the disease as a result of the delay in diagnosis.

  5. Squamous cell lung carcinoma presenting as melena: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Ibrahim Azar

    2017-10-01

    Full Text Available Lung cancer has a predilection to widely metastasize to the liver, bone, brain and adrenal glands. Metastasis of primary lung tumors to the stomach is infrequent, with only sporadic cases reported. Most cases are asymptomatic and diagnosed post-mortem on autopsy. The incidence of symptomatic gastrointestinal metastases is extremely rare. Herein, we describe a case of gastric metastasis by squamous cell lung carcinoma, presenting as melena and diagnosed by esophagogastroduodenoscopy. To the best of our knowledge, only twenty other cases in the English literature have reported symptomatic gastric metastasis of lung cancer diagnosed by endoscopic biopsy. A brief review of the literature shows gastric metastasis of lung cancer to have a predilection to occur most frequently in male smokers with the most common type of tumor likely to be squamous cell carcinoma.

  6. Metastatic breast carcinoma in the mandible presenting as a periodontal abscess: a case report

    Directory of Open Access Journals (Sweden)

    Tosios Konstantinos

    2011-07-01

    Full Text Available Abstract Introduction Tumors can metastasize to the oral cavity and affect the jaws, soft tissue and salivary glands. Oral cavity metastases are considered rare and represent approximately 1% of all oral malignancies. Because of their rarity and atypical clinical and radiographic appearance, metastatic lesions are considered a diagnostic challenge. The purpose of this report is to present a rare case of a metastatic breast carcinoma mimicking a periodontal abscess in the mandible. Case presentation A 55-year-old Caucasian woman was referred to our clinic for evaluation of bisphosphonate-induced jaw osteonecrosis. She had undergone modified radical mastectomy with axillary lymph node dissection for invasive ductal carcinoma of the left breast. Her clinical examination showed diffuse swelling and a periodontal pocket of 6 mm exhibiting suppuration in the posterior right mandible. Moreover, paresthesia of the lower right lip and chin was noted. There were no significant radiographic findings other than alveolar bone loss due to her periodontal disease. Although the lesion resembled a periodontal abscess, metastatic carcinoma of the breast was suspected on the basis of the patient's medical history. The area was biopsied, and histological analysis confirmed the final diagnosis of metastatic breast carcinoma. Conclusion The general dentist or dental specialist should maintain a high level of suspicion while evaluating patients with a history of cancer. Paresthesias of the lower lip and the chin should be considered ominous signs of metastatic disease. This case highlights the importance of the value of a detailed medical history and thorough clinical examination for the early detection of metastatic tumors in the oral cavity.

  7. Present status of fast neutron therapy for the malignant tumors

    Energy Technology Data Exchange (ETDEWEB)

    Tsunemoto, H; Morita, S; Honke, Y [National Inst. of Radiological Sciences, Chiba (Japan)

    1980-04-01

    Fast neutron therapy has been applied to the treatment of cancer of the head and the neck, prostatic cancer, osteosarcoma, and malignant melanoma, and the basic treatment schedule for this therapy for them has been almost established. The effectiveness of this therapy for squamous cell carcinoma of the uterus will be established by the results of future clinical application of this therapy. It is expected that postoperative irradiation of fast neutron will decrease local recurrence of adenocarcinoma of the uterus. Treatment schedule for fast neutron therapy for esophageal cancer and lung cancer must be established, and moreover, it is necessary to apply this therapy to the treatment of gastric and pancreatic cancer.

  8. Effects of marital status on survival of hepatocellular carcinoma by race/ethnicity and gender.

    Science.gov (United States)

    Wu, Wenrui; Fang, Daiqiong; Shi, Ding; Bian, Xiaoyuan; Li, Lanjuan

    2018-01-01

    It is well demonstrated that being married is associated with a better prognosis in multiple types of cancer. However, whether the protective effect of marital status varied across race/ethnicity and gender in patients with hepatocellular carcinoma remains unclear. Therefore, we aimed to evaluate the roles of race/ethnicity and gender in this relationship. We identified eligible patients from Surveillance, Epidemiology and End Results (SEER) database during 2004-2012. Overall and cancer-specific survival differences across marital status were compared by Kaplan-Meier curves. We also estimated crude hazard ratios (CHRs) and adjusted hazard ratios (AHRs) with 95% confidence intervals (CIs) for marital status associated with survival by race/ethnicity and gender in Cox proportional hazard models. A total of 12,168 eligible patients diagnosed with hepatocellular carcinoma were included. We observed that married status was an independent protective prognostic factor for overall and cancer-specific survival. In stratified analyses by race/ethnicity, the AHR of overall mortality (unmarried vs married) was highest for Hispanic (AHR =1.25, 95% CI, 1.13-1.39; P married patients obtained better survival advantages. Race/ethnicity and gender could influence the magnitude of associations between marital status and risk of mortality.

  9. Present status and subjects of food irradiation in the world

    International Nuclear Information System (INIS)

    Hayashi, Toru

    1995-01-01

    Food irradiation is the technology of irradiating such radiations as gamma ray and electron beam to foods and farm products, and its objectives are the prevention of germination of potatoes and onions, the insecticide of cereals and fruits, the adjustment of the ripeness of fruits and vegetables, the sterilization of chickens and spices and so on. The food irradiation as the technology for preventing the loss of foods, the food irradiation as the substitute for the fumigation with chemicals and the food irradiation for improving food sanitation are discussed. The history of the soundness test of irradiated foods and the opinion of the international organizations are described. The safety evaluation in view of poisonous effect, nutrition and microorganisms is carried out, and the safety of the foods irradiated with the dose less than 10 kGy has been proved. The examples of utilizing food irradiation for sterilization, insecticide and germination prevention are shown. The present status of its practical use in America and Europe and the move of such international organizations as IAEA, FAO and WHO are reported. (K.I.)

  10. Present status of intermediate band solar cell research

    International Nuclear Information System (INIS)

    Cuadra, L.; Marti, A.; Luque, A.

    2004-01-01

    The intermediate band solar cell is a theoretical concept with the potential for exceeding the performance of conventional single-gap solar cells. This novel photovoltaic converter bases its superior theoretical efficiency over single-gap solar cells by enhancing its photogenerated current, via the two-step absorption of sub-band gap photons, without reducing its output voltage. This is achieved through a material with an electrically isolated and partially filled intermediate band located within a higher forbidden gap. This material is commonly named intermediate band material. This paper centres on summarising the present status of intermediate band solar cell research. A number of attempts, which aim to implement the intermediate band concept, are being followed: the direct engineering of the intermediate band material, its implementation by means of quantum dots and the highly porous material approach. Among other sub-band gap absorbing proposals, there is a renewed interest on the impurity photovoltaic effect, the quantum well solar cells and the particularly promising proposal for the use of up- and down-converters

  11. Progress and present status of ITER cryoline system

    International Nuclear Information System (INIS)

    Badgujar, S.; Bonneton, M.; Chalifour, M.; Forgeas, A.; Serio, L.; Sarkar, B.; Shah, N.

    2014-01-01

    The cryoline system at ITER forms a very complex network localized inside the Tokamak building, on a dedicated plant bridge and in cryoplant areas. The cooling power produced in the cryoplant is distributed via these lines with a total length of about 3.7 km and interconnecting all the cold boxes of the cryogenic system as well as the cold boxes of various clients (magnets, cryopumps and thermal shield). Distinct layouts and polygonal geometry, nuclear safety and confinement requirements, difficult installation and in-service inspection/repair demand very high reliability and availability for the cryolines. The finalization of the building-embedded plates for supporting the lines, before the detailed design, has made this project technologically more challenging. The conceptual design phase has been completed and procurement arrangements have been signed with India, responsible for providing the system of cryolines and warm lines to ITER, as in kind contribution. The prototype test for the design and performance validation has been planned on a representative cryoline section. After describing the basic features and general layout of the ITER cryolines, the paper presents key design requirements, conceptual design approach, progress and status of the cryolines project as well as challenges to build such a complex cryoline system

  12. Design of the muon collider lattice: Present status

    International Nuclear Information System (INIS)

    Garren, A.; Courant, E.; Gallardo, J.

    1996-05-01

    The last component of a muon collider facility, as presently envisioned, is a colliding-beam storage ring. Design studies on various problems for this ring have been in progress over the past year. In this paper we discuss the current status of the design. The projected muon currents require very low beta values at the IP, β* = 3 mm, in order to achieve the design luminosity of L = 10 35 cm -2 s -1 . The beta values in the final-focus quadrupoles are roughly 400 km. To cancel the corresponding chromaticities, sextupole schemes for local correction have been included in the optics of the experimental insertion. The hour-glass effect constraints the bunch length to be comparable too. To obtain such short bunches with reasonable rf voltage requires a very small value of the momentum compaction a, which can be obtained by using flexible momentum compaction (FMC) modules in the arcs. A preliminary design of a complete collider ring has now been made; it uses an experimental insertion and arc modules as well as a utility insertion. The layout of this ring is shown schematically, and its parameters are summarized. Though some engineering features are unrealistic, and the beam performance needs some improvement, we believe that this study can serve as the basis for a workable collider design. The remaining sections of the paper will describe the lattice, show beam behaviour, and discuss future design studies

  13. [Present status and sustainable development of Dendrobium officinale industry].

    Science.gov (United States)

    Wu, Yunqin; Si, Jinping

    2010-08-01

    To understand the present status and characteristics of Dendrobium officinale industry and to provide a rationale for the sustainable industrial development. Based on references and an on-site investigation of main Dendrobium officinale-producing enterprises and market, to analyze main existing problems and to propose suggestions for sustainable development. More than 10 provinces and regions are involved in the production around the center of Zhejiang and Yunnan provinces. These two provinces are different from each other in development pattern. Yunnan adopts a mode of companies minus farmer households but Zhejiang mainly employs a mode that a leading company establishes a production base with production, processing and marketing combined together. Zhejiang mode is characterized by high tech, high investment, high risk and high return. Existence of non-genuine species, stagnancy in development and application of varieties and techniques for quality control and a narrow channel for marketing are the key problems limiting sustainable development of the industry. The key to sustainable development of the industry is to establish a technological alliance to speed up development of common techniques and application of integrated innovations, to strengthen self-discipline and monitoring of production, and to expand sales market.

  14. Dengue vector control: present status and future prospects.

    Science.gov (United States)

    Yap, H H; Chong, N L; Foo, A E; Lee, C Y

    1994-12-01

    Dengue Fever (DF) and Dengue Haemorrhagic Fever (DHF) have been the most common urban diseases in Southeast Asia since the 1950s. More recently, the diseases have spread to Central and South America and are now considered as worldwide diseases. Both Aedes aegypti and Aedes albopictus are involved in the transmission of DF/DHF in Southeast Asian region. The paper discusses the present status and future prospects of Aedes control with reference to the Malaysian experience. Vector control approaches which include source reduction and environmental management, larviciding with the use of chemicals (synthetic insecticides and insect growth regulators and microbial insecticide), and adulticiding which include personal protection measures (household insecticide products and repellents) for long-term control and space spray (both thermal fogging and ultra low volume sprays) as short-term epidemic measures are discussed. The potential incorporation of IGRs and Bacillus thuringiensis-14 (Bti) as larvicides in addition to insecticides (temephos) is discussed. The advantages of using water-based spray over the oil-based (diesel) spray and the use of spray formulation which provide both larvicidal and adulticidal effects that would consequently have greater impact on the overall vector and disease control in DF/DHF are highlighted.

  15. Present status and prospects of photovoltaic market in China

    International Nuclear Information System (INIS)

    Zhao Ruirui; Shi Guang; Chen Hongyu; Ren Anfu; Finlow, David

    2011-01-01

    In 2009, the photovoltaic (PV) industry expanded greatly in China. Developing PV technology is both necessary and urgent, as China is a large country, which consumes huge amounts of energy. In addition, because China has a natural advantage of excellent solar resources, its government has provided significant support in this field. In order to motivate the PV industry, the Ministries of Finance and Construction established coordinated policies to offer financial inducements. The government will implement the Jintaiyang project in the near future: 15 billion US dollars will be invested and 294 demonstration projects will be built. The developing Chinese PV market holds great promise. The aim of this paper is to analyze the present status of the Chinese PV market, discuss the opportunities available, and the potential challenges anticipated in the developing process including some engineering roadblocks encountered in the PV system, and to outline possible future scenarios in this field. - Research highlights: → In 2009, the photovoltaic (PV) industry expanded greatly in China. → The price of electricity generated by PV will be gradually reduced. → A photovoltaic industrial chain in China has already formed. → Research on PV systems will also promote the development of improved technologies.

  16. Present construction status and future plan of JT-60

    Energy Technology Data Exchange (ETDEWEB)

    Iso, Yasuhiko; Yoshikawa, Masaji [Japan Atomic Energy Research Inst., Tokai, Ibaraki. Tokai Research Establishment

    1982-04-01

    As for the critical plasma test facility JT-60, its detailed design was initiated in 1975, and the manufacture of the main body components was started in April, 1978, through the trial manufacture and development of important components. The manufacture of all the system equipment in factories is in progress. Especially, the essential components of main body have been almost completed, and ready to be installed in the building. The building is under construction, and a part of the equipment was brought in and installed since the beginning of 1982 fiscal year. JT-60 is composed of heating system, toroidal magnetic field coil power supply, poloidal magnetic field coil power supply, total control system, associated system for main body and various measuring equipment as well as the main body which consists of vacuum vessel, toroidal and poloidal magnetic field coils, base, primary cooling system, movable limiter and evacuating system. In this report, first the significance of JT-60 development and the outline of JT-60 are described, and the present construction status is reported. The specifications of the essential equipment of the main body and heating system and the measuring system configuration are listed in tables. The aims in JT-60 design are to make plasma generating pulse width longer, to obtain higher beta value in circular cross-section plasma, to install the magnetic limiter, and to realize compound second stage heating.

  17. History and present status of field application of radiotracers, 3

    International Nuclear Information System (INIS)

    Kimura, Shigehiko; Sato, Otomaru.

    1988-01-01

    The history and present status of the utilization of RI tracers for hydrology are described by dividing into surface water and groundwater. By the birth of nuclear reactors, the availability of RIs became easy, and the utilization of tracers for hydrology has been attempted worldwide. The large scale development of water resources is required for increasing agricultural production, and the analysis of the actual condition of hydrological phenomena is indispensable for the purpose. The hydrology committee of IAEA aided the development of new techniques in the peaceful use of atomic energy, and let developing countries use the developed techniques together with researchers. The research on the field application of RI tracers in Japan began in agriculture, and the investigation of water leak in dams, the measurement of flow rate and flow velocity in rivers, the detection of the state of sand movement on sea bottom, the analysis of groundwater flow and so on have been carried out. Also the recent situation in foreign countries is reported about the measurement of flow rate, the measurement of flowing-down time and diffusion, the analysis of the behavior of lake water, the movement of mud and sediment, and the analysis of groundwater flow. (Kako, I.)

  18. History and present status of field application of radiotracers, 3

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Shigehiko; Sato, Otomaru

    1988-06-01

    The history and present status of the utilization of RI tracers for hydrology are described by dividing into surface water and groundwater. By the birth of nuclear reactors, the availability of RIs became easy, and the utilization of tracers for hydrology has been attempted worldwide. The large scale development of water resources is required for increasing agricultural production, and the analysis of the actual condition of hydrological phenomena is indispensable for the purpose. The hydrology committee of IAEA aided the development of new techniques in the peaceful use of atomic energy, and let developing countries use the developed techniques together with researchers. The research on the field application of RI tracers in Japan began in agriculture, and the investigation of water leak in dams, the measurement of flow rate and flow velocity in rivers, the detection of the state of sand movement on sea bottom, the analysis of groundwater flow and so on have been carried out. Also the recent situation in foreign countries is reported about the measurement of flow rate, the measurement of flowing-down time and diffusion, the analysis of the behavior of lake water, the movement of mud and sediment, and the analysis of groundwater flow. (Kako, I.).

  19. A case of nonconvulsive status epilepticus presenting as ...

    African Journals Online (AJOL)

    disorders has generated interest since ancient times. ... disorders and personality disorders. ... He was hospitalised for a diagnostic work-up. ... Nonconvulsive status epilepticus is characterised by changes in behaviour, memory, affect or level ...

  20. Status of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian population.

    Science.gov (United States)

    Singh, Virendra; Singh, Laishram C; Singh, Avninder P; Sharma, Jagannath; Borthakur, Bibhuti B; Debnath, Arundhati; Rai, Avdhesh K; Phukan, Rup K; Mahanta, Jagadish; Kataki, Amal C; Kapur, Sujala; Saxena, Sunita

    2015-01-01

    Esophageal cancer incidence is reported in high frequency in northeast India. The etiology is different from other population at India due to wide variations in dietary habits or nutritional factors, tobacco/betel quid chewing and alcohol habits. Since DNA methylation, histone modification and miRNA-mediated epigenetic processes alter the gene expression, the involvement of these processes might be useful to find out epigenetic markers of esophageal cancer risk in northeast Indian population. The present investigation was aimed to carryout differential expression profiling of chromatin modification enzymes in tumor and normal tissue collected from esophageal squamous cell carcinoma (ESCC) patients. Differential mRNA expression profiling and their validation was done by quantitative real time PCR and tissue microarray respectively. Univariate and multiple logistic regression analysis were used to analyze the epidemiological data. mRNA expression data was analyzed by Student t-test. Fisher exact test was used for tissue microarray data analysis. Higher expression of enzymes regulating methylation (DOT1L and PRMT1) and acetylation (KAT7, KAT8, KAT2A and KAT6A) of histone was found associated with ESCC risk. Tissue microarray done in independent cohort of 75 patients revealed higher nuclear protein expression of KAT8 and PRMT1 in tumor similar to mRNA expression. Expression status of PRMT1 and KAT8 was found declined as we move from low grade to high grade tumor. Betel nut chewing, alcohol drinking and dried fish intake were significantly associated with increased risk of esophageal cancer among the study subject. Study suggests the association of PRMT1 and KAT8 with esophageal cancer risk and its involvement in the transition process of low to high grade tumor formation. The study exposes the differential status of chromatin modification enzymes between tumor and normal tissue and points out that relaxed state of chromatin facilitates more transcriptionally active

  1. Metastatic breast carcinoma in the mandible presenting as a periodontal abscess: a case report.

    Science.gov (United States)

    Poulias, Evmenios; Melakopoulos, Ioannis; Tosios, Konstantinos

    2011-07-01

    Tumors can metastasize to the oral cavity and affect the jaws, soft tissue and salivary glands. Oral cavity metastases are considered rare and represent approximately 1% of all oral malignancies. Because of their rarity and atypical clinical and radiographic appearance, metastatic lesions are considered a diagnostic challenge. The purpose of this report is to present a rare case of a metastatic breast carcinoma mimicking a periodontal abscess in the mandible. A 55-year-old Caucasian woman was referred to our clinic for evaluation of bisphosphonate-induced jaw osteonecrosis. She had undergone modified radical mastectomy with axillary lymph node dissection for invasive ductal carcinoma of the left breast. Her clinical examination showed diffuse swelling and a periodontal pocket of 6 mm exhibiting suppuration in the posterior right mandible. Moreover, paresthesia of the lower right lip and chin was noted. There were no significant radiographic findings other than alveolar bone loss due to her periodontal disease. Although the lesion resembled a periodontal abscess, metastatic carcinoma of the breast was suspected on the basis of the patient's medical history. The area was biopsied, and histological analysis confirmed the final diagnosis of metastatic breast carcinoma. The general dentist or dental specialist should maintain a high level of suspicion while evaluating patients with a history of cancer. Paresthesias of the lower lip and the chin should be considered ominous signs of metastatic disease. This case highlights the importance of the value of a detailed medical history and thorough clinical examination for the early detection of metastatic tumors in the oral cavity.

  2. Intradermal invasive lobular carcinoma presenting: Not everything in the skin is benign.

    Science.gov (United States)

    Eaton, Jennifer Wells; Drotman, Michele B; Sales, Rachel M; Arleo, Elizabeth Kagan

    In this case report, the history and imaging of two patients with invasive lobular carcinoma (ILC) in the skin are presented, followed by a discussion of both benign and malignant intradermal findings on breast ultrasound. Although the majority of dermal findings are benign, these cases are a reminder that malignancy can manifest within the skin. The purpose of presenting these cases together is to remind breast imagers of the importance of considering malignancy in the differential diagnosis of intradermal lesions on breast ultrasound, especially in special circumstances such as a personal history of breast cancer or associated clinical findings. Copyright © 2017. Published by Elsevier Inc.

  3. Adenoid Cystic Carcinoma of Nasal Cavity in an Adolescent Male- A Rare Presentation

    Directory of Open Access Journals (Sweden)

    Harshi Dhingra

    2018-04-01

    Full Text Available Adenoid Cystic Carcinoma (ACC is uncommonly found outside the major or minor salivary glands and is especially rare when located in nasal cavity. A case report of 13 year old boy who presented with mass in nasal cavity and epistaxis is presented here. Endoscopic removal of mass was done and histopathology revealed ACC. ACCs are slow growing tumours with a propensity for frequent local recurrence and early perineural and haematogenous spread. Early diagnosis requires a high index of suspicion for this rare pathology.

  4. Radiation education in Poland. The present status and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Goraczko, W. [Technical Univ. Poznan, Radio- and Photochemistry Dept., Poznan, Piotrowo (Poland)

    1999-09-01

    The necessity for the continued education about radiation (both in nuclear science and the technical application of radioisotopes) in the educational systems is obvious. For many years this subject has been part of a students education in physics as well as nonphysical areas of study, such as chemistry, biology, medicine, ecology and agriculture. Unfortunately in the wake of the disaster at Chernobyl, a number of negative factors have resulted that have undermined both educations in this crucial area and financial investment in Polish radiation institutes. Some sociologists have termed this behavior/viewpoint 'radio-phobia phenomena'. Might I be so bold as to recoin it as 'nuclear related paranoia' since it has caused a general breakdown in rational, 'cause and effect analysis' even within respectable scientific circles, including prominent radio biologists, who now accept radiation only as a destructive factor in biological and human life. The most important factor in this campaign will be the promotion and presentation of radiation in simple-understandable terms through the following outlets, (popular articles, TV programs, objective classroom presentation and so on), designed to be easily understandable to society as a whole. In this support is to be found in some governmental and independent organization, which do attempt to show radiation as bio-positive, human friendly and an economically indispensable factor for the future. However our fight with the so-called coal lobby' will continue to be difficult. Help by international organizations such as the I.A.E.A. will not suffice in this battle. In this article the author tries to describe the Polish education system and statistical data showing the present status of radiation science, radiation education and the quantity of students and experts in the field. As a nuclear physicist and specialist in radiation protection, lecturer and an Inspector of Radiation Protection, he

  5. Iodine status in the Nordic countries – past and present

    Directory of Open Access Journals (Sweden)

    Helena Filipsson Nyström

    2016-06-01

    Full Text Available Background: Adequate iodine nutrition is dependent on ground water content, seafood, and, as many countries use iodized cow fodder, dairy products. In most countries, salt fortification programs are needed to assure adequate iodine intake. Objectives: The objectives are threefold: 1 to describe the past and present iodine situation in the Nordic countries, 2 to identify important gaps of knowledge, and 3 to highlight differences among the Nordic countries’ iodine biomonitoring and fortification policies. Design: Historical data are compared with the current situation. The Nordic countries’ strategies to achieve recommended intake and urine iodine levels and their respective success rates are evaluated. Results: In the past, the iodine situation ranged from excellent in Iceland to widespread goiter and cretinism in large areas of Sweden. The situation was less severe in Norway and Finland. According to a 1960 World Health Organization (WHO report, there were then no observations of iodine deficiency in Denmark. In Sweden and Finland, the fortification of table salt was introduced 50–75 years ago, and in Norway and Finland, the fortification of cow fodder starting in the 1950s helped improve the population's iodine status due to the high intake of milk. In Denmark, iodine has been added to household salt and salt in bread for the past 15 years. The Nordic countries differ with regard to regulations and degree of governmental involvement. There are indications that pregnant and lactating women, the two most vulnerable groups, are mildly deficient in iodine in several of the Nordic countries. Conclusion: The Nordic countries employ different strategies to attain adequate iodine nutrition. The situation is not optimal and is in need of re-evaluation. Iodine researchers, Nordic national food administrations, and Nordic governmental institutions would benefit from collaboration to attain a broader approach and guarantee good iodine health for all.

  6. Iodine status in the Nordic countries – past and present

    Science.gov (United States)

    Nyström, Helena Filipsson; Brantsæter, Anne Lise; Erlund, Iris; Gunnarsdottir, Ingibjörg; Hulthén, Lena; Laurberg, Peter; Mattisson, Irene; Rasmussen, Lone Banke; Virtanen, Suvi; Meltzer, Helle Margrete

    2016-01-01

    Background Adequate iodine nutrition is dependent on ground water content, seafood, and, as many countries use iodized cow fodder, dairy products. In most countries, salt fortification programs are needed to assure adequate iodine intake. Objectives The objectives are threefold: 1) to describe the past and present iodine situation in the Nordic countries, 2) to identify important gaps of knowledge, and 3) to highlight differences among the Nordic countries’ iodine biomonitoring and fortification policies. Design Historical data are compared with the current situation. The Nordic countries’ strategies to achieve recommended intake and urine iodine levels and their respective success rates are evaluated. Results In the past, the iodine situation ranged from excellent in Iceland to widespread goiter and cretinism in large areas of Sweden. The situation was less severe in Norway and Finland. According to a 1960 World Health Organization (WHO) report, there were then no observations of iodine deficiency in Denmark. In Sweden and Finland, the fortification of table salt was introduced 50–75 years ago, and in Norway and Finland, the fortification of cow fodder starting in the 1950s helped improve the population's iodine status due to the high intake of milk. In Denmark, iodine has been added to household salt and salt in bread for the past 15 years. The Nordic countries differ with regard to regulations and degree of governmental involvement. There are indications that pregnant and lactating women, the two most vulnerable groups, are mildly deficient in iodine in several of the Nordic countries. Conclusion The Nordic countries employ different strategies to attain adequate iodine nutrition. The situation is not optimal and is in need of re-evaluation. Iodine researchers, Nordic national food administrations, and Nordic governmental institutions would benefit from collaboration to attain a broader approach and guarantee good iodine health for all. PMID:27283870

  7. Iodine status in the Nordic countries - past and present.

    Science.gov (United States)

    Nyström, Helena Filipsson; Brantsæter, Anne Lise; Erlund, Iris; Gunnarsdottir, Ingibjörg; Hulthén, Lena; Laurberg, Peter; Mattisson, Irene; Rasmussen, Lone Banke; Virtanen, Suvi; Meltzer, Helle Margrete

    2016-01-01

    Adequate iodine nutrition is dependent on ground water content, seafood, and, as many countries use iodized cow fodder, dairy products. In most countries, salt fortification programs are needed to assure adequate iodine intake. The objectives are threefold: 1) to describe the past and present iodine situation in the Nordic countries, 2) to identify important gaps of knowledge, and 3) to highlight differences among the Nordic countries' iodine biomonitoring and fortification policies. Historical data are compared with the current situation. The Nordic countries' strategies to achieve recommended intake and urine iodine levels and their respective success rates are evaluated. In the past, the iodine situation ranged from excellent in Iceland to widespread goiter and cretinism in large areas of Sweden. The situation was less severe in Norway and Finland. According to a 1960 World Health Organization (WHO) report, there were then no observations of iodine deficiency in Denmark. In Sweden and Finland, the fortification of table salt was introduced 50-75 years ago, and in Norway and Finland, the fortification of cow fodder starting in the 1950s helped improve the population's iodine status due to the high intake of milk. In Denmark, iodine has been added to household salt and salt in bread for the past 15 years. The Nordic countries differ with regard to regulations and degree of governmental involvement. There are indications that pregnant and lactating women, the two most vulnerable groups, are mildly deficient in iodine in several of the Nordic countries. The Nordic countries employ different strategies to attain adequate iodine nutrition. The situation is not optimal and is in need of re-evaluation. Iodine researchers, Nordic national food administrations, and Nordic governmental institutions would benefit from collaboration to attain a broader approach and guarantee good iodine health for all.

  8. Intramedullary spinal cord metastasis from colonic carcinoma presenting as Brown-Sequard syndrome: a case report

    LENUS (Irish Health Repository)

    Kaballo, Mohammed A

    2011-08-02

    Abstract Introduction Intramedullary spinal cord metastasis is very rare. The majority are discovered incidentally during autopsy. Most symptomatic patients present with rapidly progressive neurological deficits and require immediate examination. Few patients demonstrate features of Brown-Séquard syndrome. Radiotherapy is the gold-standard of therapy for Intramedullary spinal cord metastasis. The overall prognosis is poor and the mortality rate is very high. We present what is, to the best of our knowledge, the first case of Intramedullary spinal cord metastasis of colorectal carcinoma presenting as Brown-Séquard syndrome. Case presentation We present the case of a 71-year-old Caucasian man with colonic adenocarcinoma who developed Intramedullary spinal cord metastasis and showed features of Brown-Séquard syndrome, which is an uncommon presentation of Intramedullary spinal cord metastasis. Conclusion This patient had an Intramedullary spinal cord metastasis, a rare form of metastatic disease, secondary to colonic carcinoma. The metastasis manifested clinically as Brown-Séquard syndrome, itself a very uncommon condition. This syndrome is rarely caused by intramedullary tumors. This unique case has particular interest in medicine, especially for the specialties of medical, surgical and radiation oncology. We hope that it will add more information to the literature about these entities.

  9. [Umbilical blood-gas status at cesarean section for breech presentation: a comparison with vertex presentation].

    Science.gov (United States)

    Haruta, M; Saeki, N; Naka, Y; Funato, T; Ohtsuki, Y

    1989-10-01

    Umbilical blood-gas status at elective cesarean section with oxygen inhalation for breech presentation (25 cases) was compared with that for vertex presentation (25 cases), so as to confirm the security of full-term breech fetuses delivered by cesarean section under spinal anesthesia. Umbilical arterial oxygen levels were significantly lower in the breech group (Mean PO2:18.9 mmHg; SO2:37.3%; Oxygen content:7.6 ml/dl). The number of hypoxemic fetuses was significantly higher in the breech group (the breech: 7; the vertex; 0). The other umbilical blood-gas values revealed no significant differences between the breech and vertex groups, and were within normal limits in both groups. Oxygen extraction in the breech (Mean: 49.0%) was higher than that in the vertex (32.9%). Therefore decreased umbilical blood flow in the breech was suggested. The incidence of depression at 1 minute after delivery in the breech infants (24%) was significantly higher than that in the vertex infants (0%). It became obvious in the breech that as the interval between the uterine incision and delivery increased, umbilical arterial blood tended to acidosis and the 1 minute Apgar score decreased. Cesarean section for breech presentation requires sufficient and optimal incisions of the abdominal wall and uterus as well as a skillful manual delivery technique, because the fetus or neonate should be protected against asphyxia resulting from umbilical compression and prolonged delivery interval.

  10. Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status.

    Science.gov (United States)

    Hanyuda, Akiko; Cao, Yin; Hamada, Tsuyoshi; Nowak, Jonathan A; Qian, Zhi Rong; Masugi, Yohei; da Silva, Annacarolina; Liu, Li; Kosumi, Keisuke; Soong, Thing Rinda; Jhun, Iny; Wu, Kana; Zhang, Xuehong; Song, Mingyang; Meyerhardt, Jeffrey A; Chan, Andrew T; Fuchs, Charles S; Giovannucci, Edward L; Ogino, Shuji; Nishihara, Reiko

    2017-05-01

    Previous studies suggest that abnormal energy balance status may dysregulate intestinal epithelial homeostasis and promote colorectal carcinogenesis, yet little is known about how host energy balance and obesity influence enterocyte differentiation during carcinogenesis. We hypothesized that the association between high body mass index (BMI) and colorectal carcinoma incidence might differ according to tumor histopathologic differentiation status. Using databases of the Nurses' Health Study and Health Professionals Follow-up Study, and duplication-method Cox proportional hazards models, we prospectively examined an association between BMI and the incidence of colorectal carcinoma subtypes classified by differentiation features. 120,813 participants were followed for 26 or 32 years and 1528 rectal and colon cancer cases with available tumor pathological data were documented. The association between BMI and colorectal cancer risk significantly differed depending on the presence or absence of poorly-differentiated foci (P heterogeneity  = 0.006). Higher BMI was associated with a higher risk of colorectal carcinoma without poorly-differentiated foci (≥30.0 vs. 18.5-22.4 kg/m 2 : multivariable-adjusted hazard ratio, 1.87; 95% confidence interval, 1.49-2.34; P trend   0.03, with the adjusted α of 0.01). High BMI was associated with risk of colorectal cancer subtype containing no poorly-differentiated focus. Our findings suggest that carcinogenic influence of excess energy balance might be stronger for tumors that retain better intestinal differentiation throughout the tumor areas.

  11. HPV Virus Transcriptional Status Assessment in a Case of Sinonasal Carcinoma.

    Science.gov (United States)

    Ilardi, Gennaro; Russo, Daniela; Varricchio, Silvia; Salzano, Giovanni; Dell'Aversana Orabona, Giovanni; Napolitano, Virginia; Di Crescenzo, Rosa Maria; Borzillo, Alessandra; Martino, Francesco; Merolla, Francesco; Mascolo, Massimo; Staibano, Stefania

    2018-03-16

    Human Papilloma Virus (HPV) can play a causative role in the development of sinonasal tract malignancies. In fact, HPV may be the most significant causative agent implicated in sinonasal tumorigenesis and is implicated in as many as 21% of sinonasal carcinomas. To date, there are no definitive, reliable and cost-effective, diagnostic tests approved by the FDA for the unequivocal determination of HPV status in head and neck cancers. We followed an exhaustive algorithm to correctly test HPV infection, including a sequential approach with p16INK4a IHC, viral DNA genotyping and in situ hybridization for E6/E7 mRNA. Here, we report a case of sinonasal carcinoma with discordant results using HPV test assays. The tumor we describe showed an irregular immunoreactivity for p16INK4a, and it tested positive for HPV DNA; nevertheless, it was negative for HR-HPV mRNA. We discuss the possible meaning of this discrepancy. It would be advisable to test HPV transcriptional status of sinonasal carcinoma on a diagnostic routine basis, not only by p16INK4a IHC assay, but also by HPV DNA genotyping and HR-HPV mRNA assessment.

  12. Multiple Primary Merkel Cell Carcinomas Presenting as Pruritic, Painful Lower Leg Tumors

    Directory of Open Access Journals (Sweden)

    Laura Blumenthal

    2015-10-01

    Full Text Available Merkel cell carcinoma (MCC is a rare and highly aggressive neuroendocrine tumor of the skin which almost exclusively presents as a solitary tumor. It is most often seen on sun-exposed regions, historically almost exclusively on the head and neck, with only rare case reports on the extremities. Although recent studies have shown increased incidence with up to 20% on the extremities, here we present one of these rare emerging presentations, with the addition of a unique treatment option. Our patient is an 80-year-old male with a 3-month history of multiple raised, rapidly enlarging tumors on the right ankle. Two separate biopsies were performed and demonstrated sheets and clusters of small blue cells filling the dermis with scant cytoplasm, dusty chromatin, and nuclear molding. Subsequent immunohistochemical stains confirmed the diagnosis of multiple primary MCC. Despite the characteristic immunohistochemical profile of primary MCC, the possibility of a metastatic neuroendocrine carcinoma from an alternate primary site was entertained, given his unusual clinical presentation. A complete clinical workup including CT scans of the chest, abdomen, and pelvis showed no evidence of disease elsewhere. Instead of amputation, the patient opted for nonsurgical treatment with radiation therapy alone, resulting in a rapid and complete response. This case represents an unusual presentation of primary MCC and demonstrates further evidence that radiation as monotherapy is an effective local treatment option for inoperable MCC.

  13. Multiple Primary Merkel Cell Carcinomas Presenting as Pruritic, Painful Lower Leg Tumors

    Science.gov (United States)

    Blumenthal, Laura; VandenBoom, Timothy; Melian, Edward; Peterson, Anthony; Hutchens, Kelli A.

    2015-01-01

    Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine tumor of the skin which almost exclusively presents as a solitary tumor. It is most often seen on sun-exposed regions, historically almost exclusively on the head and neck, with only rare case reports on the extremities. Although recent studies have shown increased incidence with up to 20% on the extremities, here we present one of these rare emerging presentations, with the addition of a unique treatment option. Our patient is an 80-year-old male with a 3-month history of multiple raised, rapidly enlarging tumors on the right ankle. Two separate biopsies were performed and demonstrated sheets and clusters of small blue cells filling the dermis with scant cytoplasm, dusty chromatin, and nuclear molding. Subsequent immunohistochemical stains confirmed the diagnosis of multiple primary MCC. Despite the characteristic immunohistochemical profile of primary MCC, the possibility of a metastatic neuroendocrine carcinoma from an alternate primary site was entertained, given his unusual clinical presentation. A complete clinical workup including CT scans of the chest, abdomen, and pelvis showed no evidence of disease elsewhere. Instead of amputation, the patient opted for nonsurgical treatment with radiation therapy alone, resulting in a rapid and complete response. This case represents an unusual presentation of primary MCC and demonstrates further evidence that radiation as monotherapy is an effective local treatment option for inoperable MCC. PMID:26594171

  14. Discordance Rate of HER2 Status in Primary Gastric Carcinomas and Synchronous Lymph Node Metastases: A Multicenter Retrospective Analysis

    Directory of Open Access Journals (Sweden)

    Antonio Ieni

    2014-12-01

    Full Text Available Background: The assessment of human epidermal growth factor receptor 2 (HER2 gene amplification is essential in order to identify those patients affected by advanced gastric cancer who may benefit from Trastuzumab targeted therapy. Materials and Methods: With the aim to investigate the concordance rate in HER2 status between primary gastric carcinoma (GC and synchronous lymphnode metastases, we investigated HER2 status in a cohort of 108 surgical formalin-fixed paraffin-embedded specimens of GC and matched synchronous metastatic lymph nodes collected from three different units of Anatomic Pathology in southern of Italy. Fleiss-Cohen weighted k statistics were used to assess the concordance rate of HER2 status. Results: HER2 amplification was observed in 17% of primary GCs and the overall concordance rate with corresponding nodal metastases was 90.74%. Changes in HER2 status between primary GC and matched synchronous metastases were evidenced in 10 (9.26% cases. Of these, 6 cases were HER2 amplified in the primary GC and not amplified in the metastases, while 4 were HER2 not amplified in the primary tumour and amplified in the lymph node metastases. Conclusions: Although at present the simultaneous determination of HER2 in advanced gastric cancer and corresponding metastatic lymph nodes is not mandatory, the possibility that the synchronous metastases of GC have a different HER2 status from that of the primary tumour is of remarkable significance; Indeed this may have influence on the therapeutic management and prognosis of the patients.

  15. Comparing Histopathological and Magnetic Resonance Imaging Based Mesorectal Fascia Status in Patients with Rectal Carcinoma

    International Nuclear Information System (INIS)

    Hassan, U.; Khan, R.; Mehmood, M. T.

    2014-01-01

    Objective: To compare mesorectal fascia status on histopathological findings with MRI based radiological mesorectal fascia status in patients with rectal carcinoma taking histopathology finding as gold standard. Study Design: Analytical study. Place and Duration of Study: Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from January 2011 to April 2012. Methodology: Biopsy proven cases of rectal adenocarcinoma undergoing abdominoperineal resection were included in this study. Microscopic examination of slides was done to determine mesorectal fascia status as involved or otherwise without knowing the results of mesorectal fascia status on MRI. Mesorectal fascia status of MRI was determined by a radiologist who was not aware of the histopathological assessment of mesorectal fascia. Mean and standard deviation was calculated for age. Frequency and percentage were calculated for gender and mesorectal fascia status. 2 x 2 table was generated to calculate sensitivity, specificity, positive predictive value and negative predictive values and diagnostic accuracy of MRI for mesorectal fascia involvement taking histopathology as gold standard. Results: The sensitivity of MRI to detect mesorectal fascia involvement was 23.07% and specificity was 70.5%. Positive predictive value of MRI was 10% and negative predictive value was 54.54%. Diagnostic accuracy of MRI for mesorectal fascia involvement was calculated as 50%. Conclusion: MRI findings regarding mesorectal fascia status as involved or otherwise are not helpful when compared with histopathological findings which is the gold standard. (author)

  16. Status of Chandigarh variable energy cyclotron and present experimental programmes

    International Nuclear Information System (INIS)

    Govil, I.M.

    2005-01-01

    The paper describes the status report of the Chandigarh variable energy cyclotron and some of the recent modifications which has improved the stability and performance of the machine considerably. The machine is now used for Proton Induced X-Ray Emission (PIXE) for trace element analysis along with nuclear irradiation for material science research and Nuclear Spectroscopy using (p, n γ) reaction. (author)

  17. The Majorana Double Beta Decay Experiment: Present Status

    Energy Technology Data Exchange (ETDEWEB)

    Aguayo, Estanislao; Avignone, Frank T.; Back, Henning O.; Barabash, Alexander S.; Beene, Jim; Bergevin, M.; Bertrand, F.; Boswell, M.; Brudanin, V.; Busch, Matthew; Chan, Yuen-Dat; Christofferson, C. D.; Collar, J. I.; Combs, Dustin C.; Cooper, R. J.; Detwiler, Jason A.; Doe, Peter J.; Efremenko, Yuri; Egorov, Viatcheslav; Ejiri, H.; Elliott, S. R.; Esterline, James H.; Fast, James E.; Fields, N.; Finnerty, P.; Fraenkle, Florian; Gehman, Victor M.; Giovanetti, G. K.; Green, M. P.; Guiseppe, V. E.; Gusey, K.; Hallin, A. L.; Hazama, R.; Henning, Reyco; Hime, Andrew; Hoppe, Eric W.; Horton, Mark; Howard, Stanley; Howe, M. A.; Johnson, R. A.; Keeter, K.; Keller, C.; Kidd, M. F.; Knecht, A.; Kochetov, Oleg; Konovalov, S.; Kouzes, Richard T.; Laferriere, Brian D.; LaRoque, B. H.; Leon, Jonathan D.; Leviner, L.; Loach, J. C.; MacMullin, S.; Marino, Michael G.; Martin, R. D.; Mei, Dong-Ming; Merriman, Jason H.; Miller, M. L.; Mizouni, Leila; Nomachi, Masaharu; Orrell, John L.; Overman, Nicole R.; Phillips II, D. G.; Poon, Alan; Perumpilly, Gopakumar; Prior, Gersende; Radford, D. C.; Rielage, Keith; Robertson, R. G. H.; Ronquest, M. C.; Schubert, Alexis G.; Shima, T.; Shirchenko, M.; Snavely, Kyle J.; Steele, David; Strain, J.; Thomas, K.; Timkin, V.; Tornow, W.; Vanyushin, I.; Varner, R. L.; Vetter, Kai; Vorren, Kris R.; Wilkerson, J. F.; Yakushev, E.; Young, A.; Yu, Chang-Hong; Yumatov, Vladimir; Zhang, C.

    2013-06-01

    The Majorana collaboration is actively pursuing research and development aimed at a tonne-scale 76Ge neutrinoless double-beta decay experiment, an R&D effort that will field approximately 40 kg of germanium detectors with mixed enrichment levels. This article provides a status update on the construction of the Demonstrator

  18. Illiteracy, Sex and Occupational Status in Present-Day China.

    Science.gov (United States)

    Lamontagne, Jacques

    This study determined the magnitude of disparity between men and women in China in relation to illiteracy and occupational status. Region and ethnicity are used as control variables. The data collected are from a 10 percent sampling of the 1982 census; the total sample size includes a population of 100,380,000 nationwide. The census questionnaire…

  19. Microinvasive ductal carcinoma in situ: Clinical presentation, imaging features, pathologic findings, and outcome

    Energy Technology Data Exchange (ETDEWEB)

    Vieira, Cristina C. [Department of Radiology, New York University School of Medicine (United States); Mercado, Cecilia L. [Department of Radiology, New York University School of Medicine (United States)], E-mail: Cecilia.mercado@nyumc.org; Cangiarella, Joan F. [Department of Pathology, New York University School of Medicine (United States); Moy, Linda; Toth, Hildegard K. [Department of Radiology, New York University School of Medicine (United States); Guth, Amber A. [Department of Surgery, New York University School of Medicine (United States)

    2010-01-15

    Objective: The purpose of our study was to describe the clinical features, imaging characteristics, pathologic findings and outcome of microinvasive ductal carcinoma in situ (DCISM). Materials and methods: The records of 21 women diagnosed with microinvasive ductal carcinoma in situ (DCISM) from November 1993 to September 2006 were retrospectively reviewed. The clinical presentation, imaging and histopathologic features, and clinical follow-up were reviewed. Results: The 21 lesions all occurred in women with a mean age of 56 years (range, 27-79 years). Clinical findings were present in ten (48%): 10 with palpable masses, four with associated nipple discharge. Mean lesion size was 21 mm (range, 9-65 mm). The lesion size in 62% was 15 mm or smaller. Mammographic findings were calcifications only in nine (43%) and an associated or other finding in nine (43%) [mass (n = 7), asymmetry (n = 1), architectural distortion (n = 1)]. Three lesions were mammographically occult. Sonographic findings available in 11 lesions showed a solid hypoechoic mass in 10 cases (eight irregular in shape, one round, one oval). One lesion was not seen on sonography. On histopathologic examination, all lesions were diagnosed as DCISM, with a focus of invasive carcinoma less than or equal to 1 mm in diameter within an area of DCIS. Sixteen (76%) lesions were high nuclear grade, four (19%) were intermediate and one was low grade (5%). Sixteen (76%) had the presence of necrosis. Positivity for ER and PR was noted in 75% and 38%. Nodal metastasis was present in one case with axillary lymph node dissection. Mean follow-up time for 16 women was 36 months without evidence of local or systemic recurrence. One patient developed a second primary in the contralateral breast 3 years later. Conclusion: The clinical presentation and radiologic appearance of a mass are commonly encountered in DCISM lesions (48% and 57%, respectively), irrespective of lesion size, mimicking findings seen in invasive carcinoma

  20. Microinvasive ductal carcinoma in situ: Clinical presentation, imaging features, pathologic findings, and outcome

    International Nuclear Information System (INIS)

    Vieira, Cristina C.; Mercado, Cecilia L.; Cangiarella, Joan F.; Moy, Linda; Toth, Hildegard K.; Guth, Amber A.

    2010-01-01

    Objective: The purpose of our study was to describe the clinical features, imaging characteristics, pathologic findings and outcome of microinvasive ductal carcinoma in situ (DCISM). Materials and methods: The records of 21 women diagnosed with microinvasive ductal carcinoma in situ (DCISM) from November 1993 to September 2006 were retrospectively reviewed. The clinical presentation, imaging and histopathologic features, and clinical follow-up were reviewed. Results: The 21 lesions all occurred in women with a mean age of 56 years (range, 27-79 years). Clinical findings were present in ten (48%): 10 with palpable masses, four with associated nipple discharge. Mean lesion size was 21 mm (range, 9-65 mm). The lesion size in 62% was 15 mm or smaller. Mammographic findings were calcifications only in nine (43%) and an associated or other finding in nine (43%) [mass (n = 7), asymmetry (n = 1), architectural distortion (n = 1)]. Three lesions were mammographically occult. Sonographic findings available in 11 lesions showed a solid hypoechoic mass in 10 cases (eight irregular in shape, one round, one oval). One lesion was not seen on sonography. On histopathologic examination, all lesions were diagnosed as DCISM, with a focus of invasive carcinoma less than or equal to 1 mm in diameter within an area of DCIS. Sixteen (76%) lesions were high nuclear grade, four (19%) were intermediate and one was low grade (5%). Sixteen (76%) had the presence of necrosis. Positivity for ER and PR was noted in 75% and 38%. Nodal metastasis was present in one case with axillary lymph node dissection. Mean follow-up time for 16 women was 36 months without evidence of local or systemic recurrence. One patient developed a second primary in the contralateral breast 3 years later. Conclusion: The clinical presentation and radiologic appearance of a mass are commonly encountered in DCISM lesions (48% and 57%, respectively), irrespective of lesion size, mimicking findings seen in invasive carcinoma

  1. Thyroid carcinoma presenting as a pertechnetate ''Hot'' nodule, but with 131I uptake: case report

    International Nuclear Information System (INIS)

    Turner, J.W.; Spencer, R.P.

    1976-01-01

    A 24-year-old woman presented with a mass on the right side of the neck; this proved to be a hyperfunctioning or hot nodule on /sup 99m/Tc-scan. Because of the firmness of the area, the study was repeated with 131 I, but the region did not accumulate radioiodide. The tissue showing this discrepant handling of pertechnetate and radioiodide was surgically removed and identified as a follicular carcinoma with papillary foci. A brief review of the literature data on the disassociation of thyroid trapping and organification functions, and hence of possible discrepancies between pertechnetate and radioiodide uptake, is given

  2. Follicular variant of papillary carcinoma presenting as a hyperfunctioning thyroid nodule.

    Science.gov (United States)

    Gabalec, Filip; Svilias, Ioannis; Plasilova, Ivana; Hovorkova, Eva; Ryska, Aler; Horacek, Jiri

    2014-03-01

    In this study, we describe a case of papillary carcinoma in a 15-year-old girl who presented with a hyperfunctioning (hot) thyroid nodule and discuss it in the context of current management guidelines for patients with thyroid nodules. In adults, hot nodules rarely require cytologic or histologic evaluation, and hyperthyroidism is often treated with radioiodine (131I). However, in children and adolescents, the malignancy rate for nodules (both cold and hot) is higher and surgery is often necessary. Surgery may serve as a therapy, as well as a diagnostic tool, to treat hot nodules in children and adolescents.

  3. Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass

    Directory of Open Access Journals (Sweden)

    Lilit Karapetyan

    2017-01-01

    Full Text Available Background. Sarcomatoid squamous cell carcinoma is a rare and aggressive form of cervical cancer. We report a case of metastatic sarcomatoid squamous cell carcinoma (SSCC of cervix that presented with an anterior chest wall mass. Case. A 43-year-old Hispanic female presented with a two-month history of a central chest wall mass. The patient’s only past medical history was SSCC of the cervix, stage IIB, diagnosed two years priorly. She underwent neoadjuvant chemoradiation therapy (CRT with cisplatin followed by radical hysterectomy. Surgical margins were positive which led to adjuvant CRT with carboplatin and paclitaxel. PET scan 4 months after the postoperative treatment was negative for recurrence and metastatic disease. On current presentation, the CT chest revealed anterior mediastinal destructive soft tissue mass involving sternum, and the biopsy showed SSCC. The patient received palliative radiation therapy to her chest with improvement in pain and ability to swallow. After discussing the prognosis she refused further chemotherapy and decided on hospice care. Conclusion. Despite good response to first-line therapy, SSCC tends to recur early and does not respond to second-line therapy. Radiation therapy seems to be the most effective modality for treatment, but randomized controlled trials of therapy are impractical.

  4. Present status of yellow fever: Memorandum from a PAHO Meeting

    OpenAIRE

    1986-01-01

    An international seminar on the treatment and laboratory diagnosis of yellow fever, sponsored by the Pan American Health Organization (PAHO) and held in 1984, differed from previous meetings on yellow fever because of its emphasis on the care and management of patients and because the participants included specialists from several branches of medicine, such as hepatology, haematology, cardiology, infectious diseases, pathology and nephrology. The meeting reviewed the current status of yellow ...

  5. The Majorana Double Beta Decay Experiment:. Present Status

    Science.gov (United States)

    Aguayo, E.; Avignone, F. T.; Back, H. O.; Barabash, A. S.; Beene, J. R.; Bergevin, M.; Bertrand, F. E.; Boswell, M.; Brudanin, V.; Busch, M.; Chan, Y.-D.; Christofferson, C. D.; Collar, J. I.; Combs, D. C.; Cooper, R. J.; Detwiler, J. A.; Doe, P. J.; Efremenko, Yu.; Egorov, V.; Ejiri, H.; Elliott, S. R.; Esterline, J.; Fast, J. E.; Fields, N.; Finnerty, P.; Fraenkle, F. M.; Gehman, V. M.; Giovanetti, G. K.; Green, M. P.; Guiseppe, V. E.; Gusey, K.; Hallin, A. L.; Hazama, R.; Henning, R.; Hime, A.; Hoppe, E. W.; Horton, M.; Howard, S.; Howe, M. A.; Johnson, R. A.; Keeter, K. J.; Keller, C.; Kidd, M. F.; Knecht, A.; Kochetov, O.; Konovalov, S. I.; Kouzes, R. T.; Laferriere, B. D.; Laroque, B. H.; Leon, J.; Leviner, L. E.; Loach, J. C.; Macmullin, S.; Marino, M. G.; Martin, R. D.; Mei, D.-M.; Merriman, J. H.; Miller, M. L.; Mizouni, L.; Nomachi, M.; Orrell, J. L.; Overman, N. R.; Phillips, D. G.; Poon, A. W. P.; Perumpilly, G.; Prior, G.; Radford, D. C.; Rielage, K.; Robertson, R. G. H.; Ronquest, M. C.; Schubert, A. G.; Shima, T.; Shirchenko, M.; Snavely, K. J.; Steele, D.; Strain, J.; Thomas, K.; Timkin, V.; Tornow, W.; Vanyushin, I.; Varner, R. L.; Vetter, K.; Vorren, K.; Wilkerson, J. F.; Yakushev, E.; Young, A. R.; Yu, C.-H.; Yumatov, V. I.; Zhang, C.

    2013-11-01

    The Majorana collaboration is actively pursuing research and development aimed at a tonne-scale 76Ge neutrinoless double-beta decay (0νββ) experiment. The current, primary focus is the construction of the Majorana Demonstrator experiment, an R&D effort that will field approximately 40 kg of germanium detectors with mixed enrichment levels. This article provides a status update on the construction of the Demonstrator.

  6. Present status and prospects of nuclear power development in China

    International Nuclear Information System (INIS)

    Zhao Renkai

    1994-01-01

    The current status and the guiding principles of nuclear power in China are discussed. With the expansion of China's reform and opening to outside world policy, the national economy growth was increased very rapidly. For continuous, stable and fast development of national economy, the safe, clean and economic nuclear energy will play an even more important role. It is envisaged that by 2020 nuclear power will account for about 20%. 1 ref., 4 tabs

  7. Present status of computational tools for maglev development

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Z.; Chen, S.S.; Rote, D.M.

    1991-10-01

    High-speed vehicles that employ magnetic levitation (maglev) have received great attention worldwide as a means of relieving both highway and air-traffic congestion. At this time, Japan and Germany are leading the development of maglev. After fifteen years of inactivity that is attributed to technical policy decisions, the federal government of the United States has reconsidered the possibility of using maglev in the United States. The National Maglev Initiative (NMI) was established in May 1990 to assess the potential of maglev in the United States. One of the tasks of the NMI, which is also the objective of this report, is to determine the status of existing computer software that can be applied to maglev-related problems. The computational problems involved in maglev assessment, research, and development can be classified into two categories: electromagnetic and mechanical. Because most maglev problems are complicated and difficult to solve analytically, proper numerical methods are needed to find solutions. To determine the status of maglev-related software, developers and users of computer codes were surveyed. The results of the survey are described in this report. 25 refs.

  8. CEA-producing urothelial cell carcinoma with metastasis presenting as a rectal adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Ming-Hsin Yang

    2012-11-01

    Full Text Available This is a case study of a 61-year-old male who presented with difficult defecation for 1 month. A circumferential submucosal rectal tumor was noted on a digital rectal examination and colonoscopy. Laboratory examination revealed high serum levels of carcinoembryonic antigen (CEA; 43.75 ng/mL and carbohydrate antigen 19-9 (CA19-9; 11,790 U/mL. In addition, tumor biopsies revealed a poorly differentiated adenocarcinoma of the rectum with intact mucosa. The patient had history of advanced stage-T2 urothelial cell carcinoma of bladder, which had been downstaged to T0 by neoadjuvant chemotherapy followed by radical cystectomy 1 year prior. After investigating the initial bladder tumor specimens, a small portion of the tumor with high CEA expression comparable to the submucosal rectal tumor was found. The size of the tumor was reduced and the levels of the tumor markers decreased after administering FOLFIRI chemotherapy targeted at the adenocarcinoma. Although neoadjuvant chemotherapy may have a selective pressure to eliminate most urothelial cell carcinoma, physicians should be aware that it can lead to rectal metastasis via CEA-producing components.

  9. Double Feature: Carcinoma and Sarcoma Present in a Single Breast Tumor

    Directory of Open Access Journals (Sweden)

    Catherine M. Stefaniuk

    2012-01-01

    Full Text Available Introduction. Primary breast sarcomas (PBSs are rare nonepithelial breast tumors compromised of mesenchymal mammary tissue. Although its rare nature has made the best mode of PBS treatment difficult to determine, it seems better to treat it more like a sarcoma creating clear negative margins verses breast carcinoma utilizing lumpectomy, partial mastectomy, and total mastectomy. Case. A 47-year-old obese Caucasian postmenopausal female G2P2 presents with a breast lump demonstrating a histological sample with a biphasic pattern consistent with both ductal carcinoma containing typical malignant epithelial cells and sarcomatous differentiation of carcinosarcoma. Conclusion. Carcinosarcoma is a rare breast malignancy. Sarcomas of the breast tend to be negative for estrogen receptor and lack known risk factors. Current recommended treatment is to treat breast sarcomas like other soft tissue sarcomas by performing wide local excision instead of partial mastectomy. Antiestrogens and other chemotherapeutic agents typically used in breast epithelial malignancies are not recommended since these sarcomas tend to be negative with these receptors.

  10. Diagnosis of Churg-Strauss Syndrome Presented With Neuroendocrine Carcinoma: A Case Report.

    Science.gov (United States)

    Park, Dayun; Lee, Ho Jun; Lee, Kwang Hoon; Kwon, Bum Sun; Park, Jin-Woo; Nam, Ki Yeun; Lee, Kyoung Hwan

    2017-06-01

    Churg-Strauss syndrome (CSS) is a rare systemic vasculitis that affect small and medium-sized blood vessels and is accompanied by asthma, eosinophilia, and peripheral neuropathy. This report describes a case of a 52-year-old man who had a history of sinusitis, asthma, and thymus cancer and who had complained of bilateral lower extremity paresthesia and weakness for a month. Peripheral neuropathy was detected by electrodiagnostic studies. Resection of a mediastinal mass, which was diagnosed as thymic neuroendocrine carcinoma, was performed five months before his visit. After thymectomy, peripheral blood tests revealed a gradual increase in eosinophils. Two months after surgery, he was admitted to the hospital for dyspnea, and nodules of focal consolidation were found in his chest X-ray. One month later, pyoderma occurred in the right shin, and the skin biopsy showed extravascular eosinophilic infiltration. He was diagnosed with CSS after thymectomy, and we report a very rare case of CSS presented with thymic neuroendocrine carcinoma.

  11. MRI findings of nasopharyngeal carcinoma in patients presenting with ocular sings

    International Nuclear Information System (INIS)

    Jiang Bin; Wang Zhenchang; Xian Junfang

    2010-01-01

    Objective: To study the MRI features of nasopharyngeal carcinoma (NPC) in patients who presented with ocular abnormalities. Methods: The clinical signs and MRI features of Ⅲ, Ⅳ and/or Ⅵ cranial nerve involvement in 22 cases of histologically proved nasopharyngeal carcinoma were retrospectively analyzed. Results: All 22 cases showed perineural tumor spread along the course of Ⅲ, Ⅳ and Ⅵ cranial nerve, Diplopia was the most common sign, occurred in 14/22 patients. The incidence of incomplete palsy of Ⅲ, Ⅳ and Ⅵ cranial nerve were 16/44, 7/44 and 4/44, respectively. There were four types of abnormal MRI findings: cavernous sinus thickening (10/44) and mass (16/44), superior orbital fissure enlargement (4/44) and abnormal signals (9/44), thickened oculomotor muscles with obscured adjacent fatty space and abnormal enhancement (10/44). The dynamic contrast enhancement patterns of the masses in cavernous sinus and orbital were the same as that of nasopharynx lesions; all appeared as rapid initial enhancement followed by a plateau phase. Conclusion: Oculomotor nerve involvement can be the first clinical signs of NPC, and MRI can show the perineural extension along the Ⅲ, Ⅳ and Ⅵ cranial nerve in NPC. (authors)

  12. Concurrent Presentation of Erythrodermic Lichen Planus and Squamous Cell Carcinoma: Coincidence or Malignant Transformation?

    Science.gov (United States)

    Ali, Neema M; Bhat, Ramesh; Rao, Shwetha B

    2015-01-01

    Lichen planus is a common papulosquamous disorder affecting about 1-2% of the population, neoplastic transformation of cutaneous lichen planus lesions occurs very rarely. A 40 year old female patient presented with a 1 year history of developing multiple, itchy, pigmented lesions over both lower legs which gradually spread to involve the whole body. A few tense bullae were seen on the extremities. An erythematous fleshy lesion was seen on the upper aspect of the left buttock. Skin biopsy from a plaque on the right forearm showed features suggestive of lichen planus. Skin biopsy of a bullae showed a sub epidermal bulla filled with a mixed inflammatory infiltrate. Direct immunofluorescence revealed no immunoreactants along the basement membrane zone. A diagnosis of erythrodermic lichen planus with bullous lichen planus was made. Biopsy of fleshy lesion of left buttock revealed a moderately differentiated squamous cell carcinoma. Erythrodermic lichen planus with bullous lesions and secondary squamous cell carcinoma; these occurences in a single patient is extremely rare and has not been previously reported to the best of our knowledge.

  13. Human papillomavirus-16 presence and physical status in lung carcinomas from Asia

    Directory of Open Access Journals (Sweden)

    Morewaya Jacob

    2010-11-01

    Full Text Available Abstract Background Although human papillomavirus (HPV genome has been detected in lung cancer, its prevalence is highly variable around the world. Higher frequencies have been reported in far-east Asian countries, when compared with European countries. The present study analysed the HPV-16 presence in 60 lung carcinomas from the Asian countries China, Pakistan and Papua New Guinea. Results HPV-16 was present in 8/59 (13% samples. According to histological type, HPV-16 was detected in 8/18 (44% squamous cell carcinomas (SQCs, which were mainly from Pakistan; 0/38 (0% adenocarcinomas (ACs, which were mainly from China; and in 0/4 (0% small cell carcinomas (SCLCs. The observed histological difference was statistically significant (p Conclusion These results support the notion that HPV-16 infection is highly associated with SQCs in Pakistan. Our results show a frequent HPV-16 integration in SQCs, although the low viral load casts doubt respect a direct etiological role of HPV in lung carcinomas from Asia. Additional HPV-16 characterization is necessary to establish a direct or indirect etiological role of HPV in this malignancy.

  14. An unusual presentation of multiple cavitated lung metastases from colon carcinoma

    Directory of Open Access Journals (Sweden)

    Iannace Alessandro

    2011-05-01

    Full Text Available Abstract Background Consolidation with or without ground-glass opacity is the typical radiologic finding of lung metastases of adenocarcinoma from the gastrointestinal tract. Lung excavated metastases from gastrointestinal carcinoma are very rare. Case presentation The authors describe an unusual presentation of multiple cavitated lung metastases from colon adenocarcinoma and discuss the outcome of a patient. The absence both of symptoms and other disease localizations, the investigations related to different diagnostic hypotheses and the empirical treatments caused a delay in correct diagnosis. Only a transparietal biopsy revealed the neoplastic origin of nodules. Conclusions This report demonstrates that although lung excavated metastases are described in literature, initial failure to reach a diagnosis is common. We would like to alert clinicians and radiologists to the possibility of unusual atypical features of pulmonary metastases from colon adenocarcinoma.

  15. Pure squamous cell carcinoma of the breast presenting as a pyogenic abscess: a case report.

    Science.gov (United States)

    Nair, Vimoj J; Kaushal, Vivek; Atri, Rajeev

    2007-08-01

    The field of oncology is studded with fascinating case reports of rarities, and management of breast cancer by the oncologist has, at times, resulted in the surfacing of such instances of rarities. Pure squamous cell carcinoma (SCC) of the breast is such an example of a rare and generally aggressive malignancy constituting breast cancers. To the best of our knowledge, until 2006, only 5 patients of primary SCC of the breast, which presented clinically as breast abscess, have been reported in medical literature. We report the sixth worldwide case of pure primary SCC of the breast presenting as an abscess. In this report, we highlight the fact that a benign lesion like breast abscess can harbor such a rare malignancy. Clinicians should be aware of that fact, and adequate investigations should be done to rule out that possibility. Extensive literature review has been done to discuss the clinical and radiologic features as well as management of this rare lesion.

  16. Hepatocellular carcinoma presenting as an isolated sphenoid sinus lesion: a case report.

    Science.gov (United States)

    Tandon, Shantanu; Nair, Arun; Sawkar, Anisha; Balasubramanya, A M; Hazarika, Diganta

    2012-01-01

    We report a rare case of a metastatic sphenoid sinus lesion originating from an undiagnosed hepatocellular carcinoma (HCC) in a 53-year-old man who presented with gradually progressive external ophthalmoplegia. Imaging showed a right sphenoid sinus lesion infiltrating the parasellar region. Although a primary sphenoid biopsy was inconclusive, positive hepatitis B surface antigen and CT-guided fine-needle aspiration cytology suggested an HCC. A repeat endoscopic biopsy from the sphenoid with immunohistochemistry confirmed the lesion to be metastatic HCC. Metastasis to the paranasal sinuses is extremely rare, and metastasis from a liver primary even more rare. Because of clinical and radiologic similarity between the primary and metastatic lesions, metastasis to the sphenoid sinus is often undiagnosed. Patients with features suggestive of sphenoid sinus malignancy should also be evaluated for the possibility of a metastatic tumor. In this article, we emphasize the rarity of the tumor, the unusual presenting symptoms, and problems with early diagnosis.

  17. CO2 electric discharge lasers - Present status and future applications

    International Nuclear Information System (INIS)

    Reilly, J.P.

    1979-01-01

    CO 2 electric discharge lasers (EDLs) have proven themselves to be efficient sources of high-power high-quality laser energy. The paper outlines applications of high-power CO 2 EDLs, applications which are now becoming commercially viable, as well as those which are still being investigated in research laboratories. Applications of CO 2 lasers are discussed relative to industrial applications (laser welding, laser surface hardening, heat treatment, and surface chemistry modification by laser alloying and laser glazing), laser radar applications, laser-induced fusion, and laser propulsion. Attention is given to requirements of applications versus status of technology. Examples are given of the engineering solutions used to address the technology issues identified by particular laser applications

  18. The Large Hadron Collider: Present Status and Prospects

    CERN Document Server

    Evans, Lyndon R

    2000-01-01

    The Large Hadron Collider (LHC), due to be commissioned in 2005, will provide particle physics with the first laboratory tool to access the energy frontier above 1 TeV. In order to achieve this , protons must be accelerated and stored at 7 TeV, colliding with an unprecedented luminosity of 1034 cm-2 s-1. The 8.3 Tesla guide field is obtained using conventional NbTi technology cooled to below the lambda point of helium. Considerable modification of the infrastructure around the existing LEP tunnel is needed to house the LHC machine and detectors. The project is advancing according to schedule with most of the major hardware systems including cryogenics and magnets under construction. A brief status report is given and future prospects are discussed.

  19. The present status and the prospect of China research reactors

    International Nuclear Information System (INIS)

    Yongmao, Z.; Yizheng, C.

    1990-01-01

    A total of 100 reactor operation years' experience of research reactors has now been obtained in China. The type and principal parameters of China research reactors and their operating status are briefly introduced in this paper. Chinese research reactors have been playing an important role in nuclear power and nuclear weapon development, industrial and agricultural production, medicine, basic and applied science research and environmental protection, etc. The utilization scale, benefits and achievements will be given. There is a good safety record in the operation of these reactors. A general safety review is discussed. The important incidents and accidents happening during a hundred reactor operating years are described and analyzed. China has the capability of developing any type of research reactor. The prospective projects are briefly introduced

  20. The Large Hadron Collider Present Status and Prospects

    CERN Document Server

    Evans, Lyndon R

    2001-01-01

    The Large Hadron Collider (LHC), due to be commissioned in 2005, will provide particle physics with the first laboratory tool to access the energy frontier above 1 TeV. In order to achieve this , protons must be accelerated and stored at 7 TeV, colliding with an unprecedented luminosity of 1034 cm-2 s-1. The 8.3 Tesla guide field is obtained using conventional NbTi technology cooled to below the lambda point of helium. Considerable modification of the infrastructure around the existing LEP tunnel is needed to house the LHC machine and detectors. The project is advancing according to schedule with most of the major hardware systems including cryogenics and magnets under construction. A brief status report is given and future prospects are discussed.

  1. Adrenocortical carcinoma presenting as varicocele and renal vein thrombosis: a case report

    Directory of Open Access Journals (Sweden)

    Horne John M

    2011-08-01

    Full Text Available Abstract Introduction Adrenocortical carcinomas are rare aggressive tumors. Their annual incidence is approximately one to two per million among the population of the United States of America. Patients with active endocrine tumors often present with Cushing's syndrome accompanied by virilizing features. Conversely, patients with non-functioning tumors may present with symptoms related to a mass-occupying lesion, such as abdominal pain and flank pain. Although varicoceles and acute kidney injuries are common problems in medicine, they are uncommon presentations of these rare tumors and easy to miss. We report a case of a large adrenocortical carcinoma that presented as testicular pain, varicocele, and acute kidney injury secondary to renal vein thrombosis. Case presentation A 54-year-old Caucasian man with a left-sided varicocele presented to our emergency department with lower abdominal pain and a decrease in urination. Four months previously, he had noticed pain and swelling in his left groin and had been diagnosed with left-sided varicocele. For one week, he began developing left-sided abdominal pain and decreased urination frequency, so he came to our emergency department for evaluation. His physical examination revealed a hard mass occupying the entire left side of his abdomen, crossing the midline, and extending to the pelvic brim. His blood tests showed acute kidney injury and mild anemia. Computed tomography of his abdomen showed a large retroperitoneal mass on the left side, displacing the left kidney inferiorly and the spleen superiorly with thoracic epidural compression. Thrombus was also identified in his left renal vein and inferior vena cava. Computed tomography of his chest showed bilateral pulmonary nodules. A computed tomography-guided abdominal mass biopsy was performed, and the diagnosis of adrenocortical carcinoma was made on the basis of pathology and immunohistochemistry. His hormonal evaluations were normal. His kidney

  2. The Eurodif program. Present status of the project

    International Nuclear Information System (INIS)

    Besse, G.

    1975-01-01

    The reasons which led Eurodif to decide for the gaseous diffusion process and the benefits which such process offers for the present time are presented. The realization of the Eurodif project (description of the plant, time schedule of the realization, electric power supply, production time-schedule) is discussed. The Eurodif marketing policy, present and future, is reported [fr

  3. Effects of marital status on survival of hepatocellular carcinoma by race/ethnicity and gender

    Directory of Open Access Journals (Sweden)

    Wu W

    2018-01-01

    Full Text Available Wenrui Wu,1,2 Daiqiong Fang,1,2 Ding Shi,1,2 Xiaoyuan Bian,1,2 Lanjuan Li1,2 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People’s Republic of China Purpose: It is well demonstrated that being married is associated with a better prognosis in multiple types of cancer. However, whether the protective effect of marital status varied across race/ethnicity and gender in patients with hepatocellular carcinoma remains unclear. Therefore, we aimed to evaluate the roles of race/ethnicity and gender in this relationship.Patients and methods: We identified eligible patients from Surveillance, Epidemiology and End Results (SEER database during 2004–2012. Overall and cancer-specific survival differences across marital status were compared by Kaplan–Meier curves. We also estimated crude hazard ratios (CHRs and adjusted hazard ratios (AHRs with 95% confidence intervals (CIs for marital status associated with survival by race/ethnicity and gender in Cox proportional hazard models.Results: A total of 12,168 eligible patients diagnosed with hepatocellular carcinoma were included. We observed that married status was an independent protective prognostic factor for overall and cancer-specific survival. In stratified analyses by race/ethnicity, the AHR of overall mortality (unmarried vs married was highest for Hispanic (AHR =1.25, 95% CI, 1.13–1.39; P<0.001 and lowest for Asian or Pacific Islander (AHR =1.13; 95% CI, 1.00–1.28; P=0.042. Stratified by gender, the AHR was higher in males (AHR =1.27; 95% CI, 1.20–1.33; P<0.001.Conclusion: We demonstrated that married patients obtained better survival advantages. Race/ethnicity and gender could influence the magnitude of associations between marital status and risk of mortality. Keywords: primary hepatocellular

  4. Radiosensitization by SAHA in Experimental Colorectal Carcinoma Models-In Vivo Effects and Relevance of Histone Acetylation Status

    International Nuclear Information System (INIS)

    Folkvord, Sigurd; Ree, Anne Hansen; Furre, Torbjorn; Halvorsen, Thomas; Flatmark, Kjersti

    2009-01-01

    Purpose: Histone deacetylase inhibitors are being evaluated as antitumor agents in ongoing clinical trials, and promising preclinical results, combined with favorable toxicity profiles, have rendered the drugs as interesting candidates for combination with other treatment modalities, such as radiotherapy. The aim of the present study was to evaluate the radiosensitizing properties of suberoylanilide hydroxamic acid (SAHA) and the possible requirement of histone hyperacetylation at radiation exposure. Methods and materials: Radiosensitization by SAHA was assessed in a colorectal carcinoma cell line and in two colorectal xenograft models by analysis of clonogenic survival and tumor growth delay, respectively. Histone acetylation status at radiation exposure was evaluated by Western blot. Results: In vitro, radiosensitization was demonstrated when cells were preincubated with SAHA, and, in the xenografts, tumor growth was delayed when the mice were treated with fractionated radiation combined with daily SAHA injections compared with radiation alone. Surprisingly, the SAHA-dependent growth delay was still present when radiation was delivered at restored baseline acetylation levels compared with maximal histone hyperacetylation. Conclusion: SAHA was an effective radiosensitizer in experimental colorectal carcinoma models, suggesting that histone deacetylase inhibition might constitute a valuable supplement to current multimodal treatment strategies in rectal cancer. The presence of histone hyperacetylation at radiation was not required to obtain an increased radiation response, questioning the validity of using histone hyperacetylation as a molecular marker for radiosensitivity.

  5. Cytologic assessment of estrogen receptor, progesterone receptor, and HER2 status in metastatic breast carcinoma.

    Science.gov (United States)

    Pareja, Fresia; Murray, Melissa P; Jean, Ryan Des; Konno, Fumiko; Friedlander, Maria; Lin, Oscar; Edelweiss, Marcia

    2017-01-01

    Discordance in the receptor status between primary breast carcinomas (PBC) and corresponding metastasis is well documented. Interrogation of the receptor status of metastatic breast carcinoma (MBC) in cytology material is common practice; however, its utility has not been thoroughly validated. We studied patients with MBC, and evaluated the concordance rates of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between PBC surgical specimens and corresponding MBC cell blocks (CBs). We correlated the findings with clinicopathologic variables and with the fixation methods used. We searched for patients with MBC diagnosed on cytology from 2007 to 2009 and selected those with ER, PR and HER2 tested in both the PBC surgical specimens and the MBC CBs. We included CBs fixed in formalin and methanol based solution (CytoLyt®). All slides were reevaluated by cytopathologists. Clinical information was retrieved from the medical records. We studied 65 patients with PBC and MBC paired specimens. The concordance rates between PBC and MBC were 78.5%, 58.5% and 96.9%, for ER, PR and HER2, respectively. When discordant, PR status switched from positive (PBC) to negative (MBC) in most cases (23/27). The PR concordance rate was 45.2% for CBs fixed in formalin and 70.6% for those fixed with CytoLyt® (p=0.047). The ER, PR and HER2 concordance rates between the PBC and MBC CBs are similar to those reported in paired surgical specimens. PR status was the most prevalent discordance and was not accompanied by a switch in ER.

  6. Beta-ureidopropionase deficiency presenting with febrile status epilepticus

    NARCIS (Netherlands)

    Assmann, Birgit E.; van Kuilenburg, Andre B. P.; Distelmaier, Felix; Abeling, Nico G. G. M.; Rosenbaum, Thorsten; Schaper, Jörg; Duran, Marinus; Mayatepek, Ertan

    2006-01-01

    Beta-ureidopropionase is the third enzyme in the catabolic pathway of uracil and thymine. To date, only three other patients are reported with this inborn error of metabolism. We report the clinical presentation of a male patient who presented at the age of 4 months after an ALTE-like event (ALTE =

  7. An Unusual Presentation of Isolated Leptomeningeal Disease in Carcinoma of Unknown Primary With Pancreatic Features

    Directory of Open Access Journals (Sweden)

    Madhurima Anne MD

    2013-06-01

    Full Text Available Leptomeningeal disease (LMD can occur in a small percentage of patients with active metastatic cancer. However, we report a case of LMD occurring during disease remission in a patient with carcinoma of unknown primary with panreaticobiliary features. A 45-year-old woman was found with mediastinal and abdominal lymphadenopathy with lymph node biopsy consistent with adenocarcinoma, expressing immunomarkers CK7, CK20, and Ca19-9 along with markedly elevated serum Ca19-9 level. The patient was started on a pancreatic cancer directed chemotherapy regimen of Folfirinox (5-fluorouracil, leucovorin, oxaliplatin, irinotecan and achieved complete response. She was then noted to have slowly rising Ca19-9 level that did not correlate with her lack of evidence of systemic disease progression. Eventually, she presented with neurologic symptoms and was found on imaging to have isolated LMD.

  8. Basaloid large cell lung carcinoma presenting as cutaneous metastasis at the colostomy site after abdominoperineal resection for rectal carcinoma.

    Science.gov (United States)

    Sabater-Marco, Vicente; García-García, José Angel; Roig-Vila, José Vicente

    2013-08-01

    The occurrence of a tumor at the colostomy site after abdominoperineal resection for rectal carcinoma is rare and it may be related to a previously resected carcinoma or another primary tumor. We report a 61-year-old man who developed an ulcerated skin nodule at her colostomy site 6 years after resection of a rectal adenocarcinoma. Histopathologically, the skin nodule was composed of atypical large and pleomorphic cells with high mitotic rate and they were arranged in nests and within lymphatic channels in the dermis. The neoplastic cells were immunoreactive for cytokeratin (CK) AE1/3, CK7, CK34ßE12, epithelial membrane antigen and vimentin while detection of human papillomavirus and Epstein-Barr virus DNA was negative. A diagnosis of basaloid large cell carcinoma of pulmonary origin was suggested and it was confirmed by computed tomography-guided fine needle aspiration of a right subpleural mass. A metastatic tumor at the colostomy site is an exceptional finding and may be the first manifestation of lung cancer, especially if it consist of pleomorphic large cells with high mitotic rate and basaloid immunophenotype. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  9. Availability of enriched stable isotopes: present status and future prospects

    International Nuclear Information System (INIS)

    Hoff, R.W.

    1986-01-01

    The Electromagnetic Isotope Enrichment Facility (EMIEF) is currently used to produce 225 enriched stable isotopes of 50 elements. Among these are included most of the known elements with stable isotopes except for the noble gases, certain light elements, monisotopic elements, etc. The EMIEF can also be used to produce enriched samples of radioactive species, most notably the isotopes of uranium and plutonium. These enriched materials are placed in either the Sales Inventory of in the Research Materials Collection (RMC). The materials in the Sales Inventory are for sale to anyone on a first come, first served basis. Prices in the most recent catalog range from $0.05/mg for 99.8% 140 Ce to $1,267/mg for 98.5% 176 Lu. The materials in the RMC are made available to US researchers (or groups that include a US investigator) on a loan basis for use in non-destructive experiments and applications. In addition, certain samples have been provided to European investigators for cross-section studies through the auspices of EURATOM and the European-American Nuclear Data Committee. The status of the enriched isotopes included in the Sales Inventory is tabulated where isotopes are listed that are either not available or are in insufficient quantity or quality to meet current requests, as of 6/30/86. These can be summarized in the following subcategories: isotopes with zero inventory (22), Isotopes of insufficient quantity (17), and isotopes with insufficient enrichment quality (10). Of these 49 species, the supplies of 10 will be replenished by the scheduled FY86 enrichments in process (isotopes of bromine, calcium, nickel, potassium, rubidium, and strontium). In Table 3 are listed isotopes where the current inventory is less than the average annual sales level for the past five years. There are 47 isotopes listed, representing 25 different elements. Thus, there exists considerable potential for a substantial increase in the number of isotopes with zero inventory

  10. Present status and future plans at the Bonn synchrotron

    International Nuclear Information System (INIS)

    Mecking, B.A.

    1984-01-01

    The electron stretcher ring ELSA presently under construction in Bonn and the associated experimental equipment are described. The ring will deliver electron and photon beams with close to 100% duty cycle for experiments in elementary particle and photonuclear physics. (author)

  11. Quasi-optical gyrotron: present status and future prospect

    International Nuclear Information System (INIS)

    Tran, M.Q.

    1989-01-01

    A review of the main experiments on quasi-optical gyrotron is presented. Methods to improve the efficiency (pencil beam electron gun and depressed collector) will be discussed. (author) 5 figs., 1 tab., 10 refs

  12. The present status of research at the Magnetic Observatory

    International Nuclear Information System (INIS)

    Sutcliffe, P.R.

    1982-01-01

    The purpose of this presentation is to outline research presently being pursued at the Magnetic Obsservatory. In order to appreciate this research, it is necessary that we first briefly examine the laboratory in which it is carried out, namely, the earth's magnetic environment. We then review each of the research fields in turn. The first two with which we deal are magnetospheric substorms and geomagnetic pulsations, which have their origins far above the earth's surface in the region known as the magnetosphere. Then coming closer to earth we consider solar quiet time (Sq) variations which originate mainly in the ionosphere. Next, down on earth, we look at a recently commenced project to model the surface geomagnetic field. Finally, going below ground level, we consider magneto-telluric studies. For each of these research projects, we present a general background description, describe some specific research results obtained by Magnetic Observatory staff over the past few years, and point out projects planned for the future

  13. Trismus, xerostomia and nutrition status in nasopharyngeal carcinoma survivors treated with radiation.

    Science.gov (United States)

    Chen, Y-J; Chen, S-C; Wang, C-P; Fang, Y-Y; Lee, Y-H; Lou, P-J; Ko, J-Y; Chiang, C-C; Lai, Y-H

    2016-05-01

    The aims of the study were to: (1) examine levels of trismus, xerostomia and nutritional status; (2) compare levels of trismus, xerostomia and nutritional status in patients with nasopharyngeal carcinoma (NPC) receiving different types of radiation modalities; and (3) identify factors related to NPC survivors' risk status for malnutrition and existing malnutrition. A cross-sectional study with consecutive sampling was conducted. NPC survivors were recruited from otolaryngology/oncology outpatient clinics in a medical centre in Northern Taiwan. Study measures included (1) Mandibular Function Impairment Questionnaire, (2) Xerostomia Questionnaire, (3) Mini Nutrition Assessment, (4) Hospital Anxiety and Depression Scale - Depression subscale, and (5) Symptom Severity Scale. A total of 110 subjects were recruited. Those receiving intensity-modulated radiation therapy had less trismus and xerostomia than patients receiving two-dimensional radiation therapy. Patients with female gender, advanced stage, completion of treatments within 1 year, higher levels of depression, more severe trismus and higher symptom severity tended to have malnutrition or were at risk of malnutrition. Trismus and xerostomia are long-term problems in some NPC survivors and may contribute to malnutrition. To better manage a patient's trismus and xerostomia and to enhance nutritional status, clinicians should develop a patient-specific care programme based on careful assessment and targeted measures to improve oral function and insure adequate nutritional intake. © 2014 John Wiley & Sons Ltd.

  14. Reactor prospects and present status of field-reversed configurations

    International Nuclear Information System (INIS)

    Hoffman, A.L.

    1995-01-01

    Field-Reversed Configurations (FRC) have an ideal geometry for a reactor, combining high beta toroidal confinement, with a linear external geometry. Present small diameter FRCs are thought to be stabilized by kinetic effects, but recent experiments in the Large s Experiment (LSX) have demonstrated stability as well into the MHD regime. Present empirical transport coefficients are already sufficient for a small pulsed reactor, but small steady state reactors will require about an order of magnitude reduction in plasma diffusivity. 13 refs., 4 figs., 1 tab

  15. Charged particle activation analysis: present status and future perspectives

    International Nuclear Information System (INIS)

    Chowdhury, D.P.

    2006-01-01

    Charged particle activation analysis is a highly sensitive nuclear analytical technique for the determination of elements at trace and ultra trace levels. CPAA involves the irradiation of samples with high energy charged particles, both light ions and heavy ions, from an accelerator in the energy range of 10 to 100 MeV. CPAA has been developed and standardized for the determination of several elements at trace levels in various types of materials using high energy ion beams from VEC machine at Kolkata. A brief review on CPAA is presented here based on our present works and its applications in future. (author)

  16. Present status of the Riken accelerator research facility (RARF)

    International Nuclear Information System (INIS)

    Kase, M.; Goto, A.; Kageyama, T.; Yokoyama, I.; Nagase, M.; Kohara, S.; Nakagawa, T.; Inabe, N.; Ikegami, K.; Kamigaito, O.; Kidera, M.; Fujita, J.; Yoneda, A.; Kobayashi, M.; Yano, Y.

    1999-01-01

    The K540-MeV RIKEN Ring Cyclotron (RRC) celebrated 10 years of successful beam operation in December 1996. The beam intensities have been increased over years to the present levels of about 500 pnA for 135 MeV/nucleon 12 C and of 2000 pnA for 24 MeV/nucleon 40 Ar. The variation of beam has now exceeded one hundred. These beams have been delivered to users in many fields. Improvements are being and will be made to upgrade the present machine to be matched as an injector to the program of the RI beam factory. (authors)

  17. Carotid artery plaque imaging. Present status and new perspectives

    International Nuclear Information System (INIS)

    Hishikawa, Tomohito; Date, Isao; Iihara, Koji; Yamada, Naoaki; Ueda, Hatsue; Nagatsuka, Kazuyuki; Miyamoto, Susumu

    2010-01-01

    At present, the management of carotid artery (CA) stenosis depends largely on the degree of stenosis. CA plaque imaging is a modality, which assesses the nature of CA plaques objectively and less invasively, that has developed remarkably in recent years. The use of CA plaque imaging in the management of CA stenosis not only reveals the degree of stenosis but it can make the selection of treatment more appropriate by taking the plaque character into consideration. In this manuscript, we introduce ultrasound, intravascular ultrasound, angiography, magnetic resonance imaging (MRI), positron emission tomography (PET) and computed tomography (CT) and describe the present situation and new perspectives of CA plaque imaging. (author)

  18. Photoionization cross sections: present status and future needs

    International Nuclear Information System (INIS)

    Manson, S.T.

    1988-01-01

    The existing experimental data situation for photoionization cross section of ground-state atoms, excited states and positive ions is reviewed. The ability of theory to predict these cross sections is also discussed. The likely progress for the near future is presented [pt

  19. Present Status of b -> s l+ l- Anomalies

    CERN Document Server

    Mahmoudi, Farvah; Neshatpour, Siavash

    2017-05-04

    We discuss the observed deviations in b -> s l+ l- processes from the Standard Model predictions and present global fits for the New Physics description of these anomalies. We further investigate the stability of the global fits under different theoretical assumptions and suggest strategies and a number of observables to clear up the source of the anomalies.

  20. The Electronic Presentation: A Status Report of International Use.

    Science.gov (United States)

    Griffin, Robert E.; And Others

    This paper describes how electronic presentations are currently used by business people. Business people in the United States and Sweden were surveyed to determine how they are using the medium. A questionnaire was mailed to 506 business people in the United States (201 returned) and to 80 business people in Sweden (76 returned). Results are…

  1. TP53 mutation and human papilloma virus status of oral squamous cell carcinomas in young adult patients.

    Science.gov (United States)

    Braakhuis, B J M; Rietbergen, M M; Buijze, M; Snijders, P J F; Bloemena, E; Brakenhoff, R H; Leemans, C R

    2014-09-01

    Little is known about the molecular carcinogenesis of oral squamous cell carcinoma (OSCC) in young adult patients. The aim of this study was to investigate the detailed TP53 mutation and human papilloma virus (HPV) status of OSCC in patients, younger than 45 years. TP53 mutations were determined with direct sequencing on paraffin-embedded carcinoma tissue from 31 young patients and compared with two older age OSCC reference groups: one from the same institute (N = 87) and an independent one (N = 675). Biologically active tumour HPV was detected by p16-immunohistochemistry followed by a HPV-DNA GP5 + /6 + -PCR. HPV16 was present in one OSCC (3%). TP53 mutations were found in 14 (45%) OSCC: five were missense and nine resulted in a truncated protein. Six of these latter were insertions or deletions of one or more nucleotides leading to frameshift, one was at a splice site and two resulted in a stop codon. The percentage of truncating mutations (64% of all mutations) was higher than that observed in the institute's reference group (44%, P = 0.23) and in the independent reference group (24%, P = 0.002). This study shows that TP53 mutations are common in OSCC of young adult patients; infection with biologically active HPV is rare. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  2. Renal cell carcinoma in India demonstrates early age of onset & a late stage of presentation

    Directory of Open Access Journals (Sweden)

    Shalini Agnihotri

    2014-01-01

    Full Text Available Background & objectives: Clinical spectrum of most of the diseases in developing countries is different from the west. Similarly whether renal cell carcinomas (RCC in a developing country like India is seen in the same spectrum in relation to the age at presentation as in the west is not described in the literature. This study was carried out to investigate the spectrum of RCC in India with regards to age of onset, stage at presentation and survival. Methods: Patients with renal tumour, treated between January 2000 to December 2012 in a tertiary care hospital in north India, were analyzed for age at presentation, clinical features and histopathological characteristics. Clinical diagnosis was made by contrast enhanced computerized tomography (CECT scans and/or magnetic resonance imaging (MRI. Renal masses diagnosed as angiomyolipoma, infective masses and hydatid cysts were excluded from the analysis. Impact of various age groups on gender, tumour size, TNM stage, Fuhrman grade, histopathological subtypes, lymph node, inferior vena cava (IVC involvement and survival was analyzed. Patients were grouped in five age groups i.e. ≤39, 40-49, 50-59, 60-69 and more than 70 yr of age. Results: Of the total 617 patients with 617 renal tumours (2 patients had bilateral tumours but only the larger tumour was considered clinically suspected as RCC, 586 had epithelial cell tumour and the remaining 31 had non epithelial cell tumour. The mean tumour size was 8.08±3.5 cm (median 7, range 1-25 cm. Tumour of less than 4 cm size was present in only 10.4 per cent patients. The mean age at diagnosis was 55.15±13.34 (median 56, range 14-91 yr years. A total of 30.03 per cent of renal tumours presented in patients younger than 50 yr of age. Though there was no difference in stage, Fuhrman′s grade, IVC involvement and lymph nodal spread among various age groups, younger patients had higher proportion of non clear cell RCC and only 48.59 per cent of them presented

  3. General concept and present status of the AMS - project

    International Nuclear Information System (INIS)

    Stan-Sion, C.; Plostinaru, D.; Catana, L.; Radulescu, M.; Marinescu, L.; Dima, R.

    1998-01-01

    sensitivities. For the same reason, the transmission to the beam line and the ion current must be maximized. Additionally, cross-contamination between different samples should be minimized. To meet all these requirements, a new cesium sputter ion source has been constructed and is under the tests. Beams from the source are focused by an optical element (Einzel lens and steerer) on the object slits of a 90 angle double-focusing Danfysik analyzing magnet. The Injector was designed using the beam optics code OPTIC 4. The same code was used to couple the beams from the injector to the other transport elements down to the entrance into the tandem accelerator. To ensure good transmission through the analyzing magnet, the width of the beam is controlled by measuring the currents on a four-fold diaphragm system placed in the object point of the magnet. The information is used to adjust focusing power and steering done by the optical element after the sputter source. At this preliminary status, the stable isotopes are monitored by a Faraday cup which is positioned by remote control into the beam axis at the image point of the analyzing magnet. Our scientific research programme is devoted to environmental AMS studies. (authors)

  4. On the present status of the Klein Paradox

    International Nuclear Information System (INIS)

    Wergeland, H.

    1980-01-01

    Klein's paradox is a solution of Dirac's equation which implies that electrons may penetrate an electrostatic potential barrier even when their kinetic energy is lower than the barrier. Since the barrier is infinitely broad this is not a case of tunneling. A number of treatments of the paradox, by Sauter, Hylleraas, Jenssen and others are discussed, and the Boundary Value Problem is treated at some length. Examples are presented with an infinitely broad barrier and with a barrier of finite breadth. (JIW)

  5. Problems and the present status of radiation educational curriculum

    International Nuclear Information System (INIS)

    Hiroi, Tadashi; Muraishi, Yukimasa; Mikado, Shogo; Watanabe, Tomohiro

    1999-01-01

    To examine teaching curriculum for radiation education requires a collective and extensive consideration on various subjects from many fields. The present study has been made from 4 points of view, namely 'physics', physics experiment', 'chemistry', and 'general science'. In 'physics', a curriculum in which learning about radiation followed by learning Newtonian mechanics was examined. Some group experiments taking radiation as the subject, a curriculum including radiation and radioactivity in high school chemistry course and general science are proposed and discussed briefly. (S. Ohno)

  6. Inertial confinement fusion: present status and future potential

    International Nuclear Information System (INIS)

    Hogan, W.J.

    1984-01-01

    Power from inertial confinement fusion holds much promise for society. This paper points out many of the benefits relative to combustion of hydrocarbon fuels and fission power. Potential problems are also identified and put in perspective. The progress toward achieving inertial fusion power is described and results of recent work at the Lawrence Livermore National Laboratory are presented. Key phenomenological uncertainties are described and experimental goals for the Nova laser system are given. Several ICF reactor designs are discussed

  7. Present status of the Tandetron Accelerator at Mutsu Establishment, JAEA

    International Nuclear Information System (INIS)

    Amano, Hikaru; Kabuto, Shoji; Kinoshita, Naoki; Suzuki, Takashi; Otosaka, Shigeyoshi; Kuwabara, Jun; Kitamura, Toshikatsu; Tanaka, Takayuki; Kitada, Yoshinobu; Watanabe, Yukiya

    2007-01-01

    The accelerator mass analyzer system at Mutsu Establishment, JAEA consists of a 3 MV tandem electrostatic accelerator and two beamlines for measuring isotope ratios of carbon and iodine. The present paper reports on (1) the operation and maintenance works in fiscal 2005, (2) the measurements of 14 C and 129 I and the related technology development, and (3) the public utilization of the system, which was started from 2006. (K.Y.)

  8. Acid agglomeration heap leaching: present status, principle and applications

    International Nuclear Information System (INIS)

    Zeng Yijun

    2004-01-01

    For extracting valuable metal from clay-bearing acidic ores of poor permeability, agglomerated acid heap leaching appears to be the most effective method, whereas conventional leaching and general heap leaching bring about unsatisfactory recovery and poor economic returns. The present state of research work on acid agglomeration worldwide and its basic principle are discussed. The first commercial application employing acid agglomeration-heap leaching in China is also introduced

  9. Present status of radiochemical double β decay study (238U)

    International Nuclear Information System (INIS)

    Chevallier, A.; Chevallier, J.; Escoubes, B.; Schulz, N.; Sens, J.C.; Madic, C.; Maillard, C.

    1989-01-01

    The reasons for which the 238 U is a suitable candidate for the β β decay processes are explained. The strategy adopted for the radiochemical separation of the 234 U is given. A chemical system based on extraction chromatography is applied. The Pu IV breakthrough curves obtained at 40C during 238 Pu/ 238 U separation cycles are presented. A short description of the chromatographic facility is given. The solution adopted for the low background α spectrometer is explained

  10. ''Use of synchrotron radiation in France: present status and perspectives''

    International Nuclear Information System (INIS)

    Thiry, P.

    1996-01-01

    LURE (laboratory for the use of electromagnetic radiation) plays an important role as a research center, as a synchrotron radiation producer and as a leading pole about new light source studies. The necessity to maintain LURE at a high level of technological competitiveness implies to build a new facility called SOLEIL. This article describes the present equipment of LURE, its activity fields and draws the prospect of synchrotron radiation in France. (A.C.)

  11. Present status of research and development on underground disposal

    International Nuclear Information System (INIS)

    1994-11-01

    Power Reactor and Nuclear Fuel Development Corporation published the technical report 'Research and development of the formation disposal of high level radioactive waste' 1991 in 1992, summarizing the results of the research and development of the formation disposal which have been advanced by dividing into three parts, that is, the investigation and research of geological environment conditions, the research and development of disposal technologies, and the research on the performance evaluation. Based on the subjects pointed out during the process of making the technical report, the results of evaluation by the state, and the opinions of those concerned, the efforts are exerted toward the second summarization expected in about 2000. By informing the present state of the research and development, in order to accept the criticism and advice, this book was published. The way of thinking and the method of advancing of the research and development of formation disposal, the present state of the research on geological environment conditions, disposal technologies and the performance evaluation are described. Also the present state of the research on stratum science in Tono and Kamaishi mines and others is reported. (K.I.)

  12. Present status of preparation to the Pan-Orthodox Council

    Directory of Open Access Journals (Sweden)

    Biskup Jerzy Pańkowski

    2014-11-01

    Full Text Available The article begins from explanation of the meaning (from the point of view of the Orthodox Church of the word „catholic” as one of the ontological attributes of the Church. Than the author presents the examples of the different kinds of meetings of Church hierarchs on the highest level and its titles/names.Than the article gives a short presentation of the initiative and history of the convene of Pan-Orthodox Council. The idea of that kind of meeting was born in the beginning of XX century on Ecumenical Patriarchate.The preparation to the Pan-Orthodox Council lasts many yearsand contains of many different kind of meetings. Meetings of the special commission that consists of representatives of each Autocephaly Orthodox Church concentrate on the different topics. During last meetings several important topics were discussed, as: Orthodox Diaspora, Autonomy and the methods of its granting, Autocephaly and the methods of its grantingand Diptychs. The author, who took part in some of these meeting,explains the positions of the various Churches in these matters as well asshares his opinions on them.In conclusion the author presents the opinion that despite many different problems on the way to prepare the Pan-Orthodox Council, this idea can be realized even in the near future.

  13. Micro-PIXE in plant sciences: Present status and perspectives

    International Nuclear Information System (INIS)

    Mesjasz-Przybylowicz, Jolanta; Przybylowicz, Wojciech J.

    2002-01-01

    Fundamental processes of plant physiology are affected or regulated by mineral nutrients. Hence understanding the mechanisms of nutrient uptake and their functions in plant metabolism is of fundamental importance in both basic and applied plant studies. The present knowledge of ion uptake mechanisms is based mostly on techniques for bulk analysis, including analysis of small (mg-sized) samples but without spatially resolved results. On the other hand, advanced studies of elemental transport at a cellular level are conducted using techniques with high and very high spatial resolution, but with low sensitivity for elemental analysis. Thus the results obtained are usually restricted to macronutrients or elements present in high quantities. There is a high demand for studies of the functions of trace elements. In addition, it is known that, depending on their concentrations, elements can play different roles in plant life. Studies related to elemental deficiency and toxicity, as well as environmental pollution, require accurate, fully quantitative methods with good spatial resolution. Ideally, these studies should be conducted on organs and tissues as far down as the cellular level. This is where micro-PIXE has been applied until present and can in the near future play a much more important role. Progress is subject to closer collaboration between plant biologists and the PIXE community in terms of addressing problems of specimen preparation, refinement of analytical protocols such as quantitative elemental mapping and the interpretation of results

  14. Present status of research and development on underground disposal

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-11-01

    Power Reactor and Nuclear Fuel Development Corporation published the technical report `Research and development of the formation disposal of high level radioactive waste` 1991 in 1992, summarizing the results of the research and development of the formation disposal which have been advanced by dividing into three parts, that is, the investigation and research of geological environment conditions, the research and development of disposal technologies, and the research on the performance evaluation. Based on the subjects pointed out during the process of making the technical report, the results of evaluation by the state, and the opinions of those concerned, the efforts are exerted toward the second summarization expected in about 2000. By informing the present state of the research and development, in order to accept the criticism and advice, this book was published. The way of thinking and the method of advancing of the research and development of formation disposal, the present state of the research on geological environment conditions, disposal technologies and the performance evaluation are described. Also the present state of the research on stratum science in Tono and Kamaishi mines and others is reported. (K.I.).

  15. Primary Signet-Ring Carcinoma in the Bladder Presenting as a Hypervascular Luminal Polypoid Mass

    International Nuclear Information System (INIS)

    Jeong, Min Sun; Choi, Seung A; Jung, Yoon Young; Cho, Young Kwon; Lee, Won Mi; Lee, Seung Wook

    2012-01-01

    Primary signet-ring carcinoma is a very aggressive and rare variant of a primary urinary bladder cancer, accounting for less than 1% of cases. We reported on a 76-year-old patient with primary signet-ring carcinoma who occurred metastatic lymphadenopathy with extranodal invasion causing intraluminal tumor thrombi in the adjacent vein, and pulmonary metastasis over the course of three months. We demonstrated the computed tomography findings of primary signet-ring carcinoma of the bladder and correlated the imaging findings with the pathologic features. We reviewed the distinguishing imaging findings of the primary signet-ring carcinoma compared with urothelial cell carcinoma, the most common subtype of the bladder cancer.

  16. A STUDY ON RELATIONSHIP BETWEEN EDUCATIONAL AND SOCIOECONOMIC STATUS AND EARLY DIAGNOSIS OF CARCINOMA BREAST IN FEMALES

    Directory of Open Access Journals (Sweden)

    Janardana Rao Venkata Kakulapati

    2018-01-01

    Full Text Available BACKGROUND Breast cancer distribution differs by geography, regional lifestyle, racial or ethnic background. In general, both breast cancer incidence and mortality are relatively lower among the female populations of Asia and Africa, relatively underdeveloped nations, and nations that have not changed to the westernised reproductive and dietary patterns. In contrast, European and North American women from heavily industrialised or westernised countries have a substantially higher incidence of breast cancer. The aim of the study is to1. Analyse the relationship between socioeconomic and educational status and early diagnosis of CA breast. 2. Emphasise the need for early detection of breast cancer. MATERIALS AND METHODS This study was carried out in 150 patients who were admitted in the Department of General Surgery. Inclusion criteria for patients in this study consist of patient of any age presenting with the lesion suspected of breast carcinoma and proved by FNAC and Tru-cut biopsy and all relevant investigations to stage the disease like chest x-ray, ultrasound abdomen, liver function test, mammography and skeletal survey done for advanced cases to rule out metastasis. Patients excluded where those who presented with symptoms of breast on clinical examination, but on investigation, there was no malignant pathology of breast and male patients with breast carcinoma excluded. Patients data was collected in standardised pro forma, which included age, socioeconomic status, level of education, duration of symptoms, detection of lump by the patient or medical practitioner into three class lower, middle and upper. The socioeconomic status defined by Kuppuswamy scale was used in this study. Literacy status classified into illiterate and educated, which is further classified into primary (I-IV, secondary (high school and higher secondary and higher education (graduate and above. RESULTS In our study, among 150 patients, 34% presented in early stage

  17. Program on fuels for transmutation: present status and prospects

    Energy Technology Data Exchange (ETDEWEB)

    Rouault, J.; Garnier, J.C.; Chauvin, N.; Pillon, S. [CEA Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. d' Etudes des Combustibles

    2001-07-01

    The performance calculations of appropriate fuel cycle facilities and reactor configurations (scenarios) relying on current reactor technologies (Pressurized Water Reactor and Fast neutrons Reactors) or innovative reactors (Accelerator Driven Systems) have proved the scientific feasibility of some P and T strategies. To insure the technological feasibility, a large program on fuels and materials is underway, including advanced concepts for PWRs and the development of specific targets (dispersed fuels) for transmutation in Fast Reactors. Experiments in different reactors including Phenix are being prepared. The program is presented and recent results are given. (author)

  18. Program on fuels for transmutation: present status and prospects

    International Nuclear Information System (INIS)

    Rouault, J.; Garnier, J.C.; Chauvin, N.; Pillon, S.

    2001-01-01

    The performance calculations of appropriate fuel cycle facilities and reactor configurations (scenarios) relying on current reactor technologies (Pressurized Water Reactor and Fast neutrons Reactors) or innovative reactors (Accelerator Driven Systems) have proved the scientific feasibility of some P and T strategies. To insure the technological feasibility, a large program on fuels and materials is underway, including advanced concepts for PWRs and the development of specific targets (dispersed fuels) for transmutation in Fast Reactors. Experiments in different reactors including Phenix are being prepared. The program is presented and recent results are given. (author)

  19. Positron emission tomography. Present status and Romanian perspectives

    International Nuclear Information System (INIS)

    Constantinescu, B.; Lungu, V.

    1995-01-01

    Basic principles of the positron emission tomography (PET) are summarised. The main PET methods using short-lived radioisotopes (i.e. 11 C, 13 N, 15 O, 18 F) are briefly reviewed. Three types of particle accelerators for radioisotopes production and medical uses (including radiotherapy), corresponding to the proton energy (E p p p < 200 MeV) are presented. PET imaging equipment and procedures are discussed. Main radiopharmaceuticals based on beta decay for PET studies and their role in medicine is also described. Finally, perspectives for a PET program in Romania (Cyclotron + Radiochemistry + Tomograph ) are discussed. (author)

  20. Electron stopping power in dosimetry. I. Evolution and present status

    International Nuclear Information System (INIS)

    Andreo, P.

    1985-01-01

    A review of the theory and the evolution of the calculation of the collision stopping power of electrons has been performed. Special emphasis has been given to those aspects and materials used in the dosimetry electron and photon beams. The important parameters mean excitation energy and the density effect correction are considered in detail to clarify the different models and data available at the present time. Updated data, comparisons and results are given using the formulation and numerical values described in this work. (author)

  1. [The present epidemiological status of African swine fever].

    Science.gov (United States)

    Hess, G

    1986-01-01

    At present, African swine fever (ASF) persists as an enzootic infection both on the African continent and in Europe (Portugal, Spain, and Sardinia). The recent outbreaks of ASF in Belgium and in the Netherlands have again demonstrated the threat of this disease to the swine population in Germany. The main reasons for this threat are the great tenacity of this virus and its stability in meat and meat products together with an immense tourism into these enzootic areas. Epizootiological peculiarities, such as virus replication in ticks and inapparent infections in wild boars are the reason why eradication of the disease has failed so far, especially when pigs are allowed to roam the countryside.

  2. The present status of the Daresbury Nuclear Structure Facility

    International Nuclear Information System (INIS)

    Voss, R.G.P.

    1983-01-01

    This paper covers the development of the Daresbury Nuclear Structure Facility from 1973 to the present. At that point, the design study had been completed for a tandem to operate initially at 20 MeV and to undergo eventual upgrading to 30 MeV, and a fully costed proposal had been submitted to the Science Research Council. In 1974, planning permission was obtained, and full financial authorization was given to proceed to the 20 MeV stage. The design of the accelerator fell into two areas. The first of these covered those aspects of the design based on known techniques and calculable properties such as the ion beam optics and dynamics and associated equipment. The second area dealt with the less certain design aspects: the behavior of insulators, their protection, the properties of charging mechanisms, accelerator tubes and vacuum systems, and the operation of a computerized control system in a hostile high-voltage environment. This paper describes the research programs and the pilot and test equipment employed to overcome these uncertainties and goes on to discuss a variety of experiments conducted at the present facility

  3. [Present status of zoonotic hemorrhagic fevers of South America].

    Science.gov (United States)

    Chastel, C

    1993-01-01

    Since 1958, the geographical distribution of Argentine hemorrhagic fever (AHF) has especially extended non only into the province of Buenos Aires but also towards the provinces of Santa Fe and Cordoba, leading to an estimated population at risk of about 1.2 M inhabitants. Recent epidemiological field studies has confirmed the major role of Calomys musculinus and C. laucha rodents in both transmission to man and conservation of Junin virus in nature. However, the human infection may result essentially from contacts with infected C. musculinus. Clinical condition of patients with AHF was greatly improved using AHF convalescent plasma and additional administration of vidarabin may still improve the results of treatment. A live attenuated vaccine, Candid No 1, is presently under evaluation in endemic foci of AHF. On the contrary Bolivian hemorrhagic fever (BHV) appears at present quite silent. A new disease resembling both AHF and BHF, the Venezuelan hemorrhagic fever, appeared in 1989 in the rural areas of central Llanos of Venezuela. The mortality was very high, reaching 23% or more among severely ill patients. The wild small rodents responsible for the disease were identified as Sigmodon alstoni and Zygotontomys brevicauda. Recent extension of agricultural practices and massive immigration may probably explain the recent emergence of this new viral zoonosis.

  4. Present status and prospects of food irradiation in France

    International Nuclear Information System (INIS)

    Laizier, J.

    1985-09-01

    Following the conclusions of the JEFCI (Joint FAO/IAEA/WHO Expert Committee on whole someness of Irradiated Food), CEA (French Atomic Energy Commission) was required by the regulatory committees, in 1981-82, to present a white book on the whole someness of irradiated foods. Following the approval of this white book it was decided to not modify hastily the current regulation of 1970; but to lighten the content of the file of request for authorization by removing its part related to toxicological evidences. This liberalization of procedure has encouraged industrial projects. A large effort of development is initiated and taken in charge locally. The CEA has very important responsabilities in this national effort of development of food irradiation. Three new designs for gamma industrial irradiators were recently improved in France specifically in view of food irradiation, beside the other more conventional designs of carrier and pallet irradiators, already available and well known. The presently available accelerators are not well fitted to food irradiation; the penetration of electrons which are produced is not high enough for food products. A french company, CGR-MeV, recently developed a linear accelerator of 10 MeV and 10 Kw, which appears very attractive

  5. Nanomaterials in the field of design ergonomics: present status.

    Science.gov (United States)

    Chowdhury, Anirban; Sanjog, J; Reddy, Swathi Matta; Karmakar, Sougata

    2012-01-01

    Application of nanotechnology and nanomaterials is not new in the field of design, but a recent trend of extensive use of nanomaterials in product and/or workplace design is drawing attention of design researchers all over the world. In the present paper, an attempt has been made to describe the diverse use of nanomaterials in product and workplace design with special emphasis on ergonomics (occupational health and safety; thermo-regulation and work efficiency, cognitive interface design; maintenance of workplace, etc.) to popularise the new discipline 'nanoergonomics' among designers, design users and design researchers. Nanoergonomics for sustainable product and workplace design by minimising occupational health risks has been felt by the authors to be an emerging research area in coming years. Use of nanomaterials in the field of design ergonomics is less explored till date. In the present review, an attempt has been made to extend general awareness among ergonomists/designers about applications of nanomaterials/nanotechnology in the field of design ergonomics and about health implications of nanomaterials during their use.

  6. Present status of the theory of πNN systems

    International Nuclear Information System (INIS)

    Mizutani, T.

    1987-01-01

    In the present discussion the existing data are compared with various model calculations within the πNN theory to assess the appropriateness of the latter. Globally the models in their present form reproduce the data quite well in view of the number of channels in which the comparison was made. From the quantitative point of view the models must be upgraded in several different ingredients. First, it is the parameters of the NN heavy meson exchange potentials when combined with the explicit pion and nucleon isobar degrees of freedom. A right choice of their values will lead to a better account of such observables like the beam asymmetries and vector analyzing power in a number of channels like NN in equilibrium πd, NN → πNN, etc. The next one may be the model for the Δ resonance (or the πN P 33 off-shell amplitude). A simple monopole or dipole form factor for the πNΔ vertex had difficulty in reproducing the major NN partial wave phase parameters. In view of the fact that dσ/dΩ for the deuteron photodisintegration in the Δ resonance region cannot be explained at all by the coupled NN-NΔ model, one should seriously consider a better model for the Δ. 39 refs., 10 figs

  7. Cosmogenic radionuclides as a synchronisation tool - present status

    Science.gov (United States)

    Muscheler, Raimund; Adolphi, Florian; Mekhaldi, Florian; Mellström, Anette; Svensson, Anders; Aldahan, Ala; Possnert, Göran

    2014-05-01

    Changes in the flux of galactic cosmic rays into Earth's atmosphere produce variations in the production rates of cosmogenic radionuclides. The resulting globally synchronous signal in cosmogenic radionuclide records can be used to compare time scales and synchronise climate records. The most prominent example is the 14C wiggle match dating approach where variations in the atmospheric 14C concentration are used to match climate records and the tree-ring based part of the 14C calibration record. This approach can be extended to other cosmogenic radionuclide records such as 10Be time series provided that the different geochemical behaviour of 10Be and 14C is taken into account. Here we will present some recent results that illustrate the potential of using cosmogenic radionuclide records for comparing and synchronising different time scales. The focus will be on the last 50000 years where we will show examples how geomagnetic field, solar activity and unusual short-term cosmic ray changes can be used for comparing ice core, tree ring and sediment time scales. We will discuss some unexpected offsets between Greenland ice core and 14C time scale and we will examine how far back in time solar induced 10Be and 14C variations presently can be used to reliably synchronise ice core and 14C time scales.

  8. Ayurvedic research and methodology: Present status and future strategies.

    Science.gov (United States)

    Chauhan, Ashutosh; Semwal, Deepak Kumar; Mishra, Satyendra Prasad; Semwal, Ruchi Badoni

    2015-01-01

    Ayurveda is a science of life with a holistic approach to health and personalized medicine. It is one of the oldest medical systems, which comprises thousands of medical concepts and hypothesis. Interestingly, Ayurveda has ability to treat many chronic diseases such as cancer, diabetes, arthritis, and asthma, which are untreatable in modern medicine. Unfortunately, due to lack of scientific validation in various concepts, this precious gift from our ancestors is trailing. Hence, evidence-based research is highly needed for global recognition and acceptance of Ayurveda, which needs further advancements in the research methodology. The present review highlights various fields of research including literary, fundamental, drug, pharmaceutical, and clinical research in Ayurveda. The review further focuses to improve the research methodology for Ayurveda with main emphasis on the fundamental research. This attempt will certainly encourage young researchers to work on various areas of research for the development and promotion of Ayurveda.

  9. Digital positron lifetime spectroscopy: present status and outlook

    International Nuclear Information System (INIS)

    Becvar, F.

    2007-01-01

    This contribution summarizes achievements in instrumentation for positron lifetime measurements with emphasis on digital spectrometric systems. A significant part of the data presented are based on a long-term exploitation of a conventional positron lifetime spectrometer developed at Charles University in early 90s, on bench-mark testing measurements with this spectrometer working temporarily in conjunction with a pair of 8-bit, 4 GS/s digitizers and on analogous measurements with a recently assembled digital positron lifetime spectrometer. In addition, results from testing experiments with microchannel plate photomultipliers are briefly reported. Further development of positron lifetime technique is discussed. (copyright 2007 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  10. Uranium exploration in India: present status and future strategies

    International Nuclear Information System (INIS)

    Maithani, P.B.

    2011-01-01

    Exploration for Uranium in India dates back to 1949, where surveys to locate atomic minerals were initiated in the well established Copper Thrust Belt (CTB) of Singhbhum, in the present day Jharkhand state. Based on the limited understanding on uranium geology, the thrust zones of Singhbhum which were popularly known for hosting Copper mineralization were targeted presuming sympathetic relation between Copper and Uranium. Exploration for uranium over the past six decades has resulted in identifying eleven major uranium deposits distributed in varied geological environs all over the country. Apart from conventional uranium mineralization, non-conventional resources like phosphorite, black shale etc. have immense potential. Even though their uranium grades will be of lower order, their uranium content will be huge due to their extensive size. In addition to intensifying uranium exploration in potential geological domains, AMD also plans to tap the non-conventional resources which will add substantially to the resource base

  11. Ayurvedic research and methodology: Present status and future strategies

    Science.gov (United States)

    Chauhan, Ashutosh; Semwal, Deepak Kumar; Mishra, Satyendra Prasad; Semwal, Ruchi Badoni

    2015-01-01

    Ayurveda is a science of life with a holistic approach to health and personalized medicine. It is one of the oldest medical systems, which comprises thousands of medical concepts and hypothesis. Interestingly, Ayurveda has ability to treat many chronic diseases such as cancer, diabetes, arthritis, and asthma, which are untreatable in modern medicine. Unfortunately, due to lack of scientific validation in various concepts, this precious gift from our ancestors is trailing. Hence, evidence-based research is highly needed for global recognition and acceptance of Ayurveda, which needs further advancements in the research methodology. The present review highlights various fields of research including literary, fundamental, drug, pharmaceutical, and clinical research in Ayurveda. The review further focuses to improve the research methodology for Ayurveda with main emphasis on the fundamental research. This attempt will certainly encourage young researchers to work on various areas of research for the development and promotion of Ayurveda. PMID:27833362

  12. Social costs of energy. Present status and future trends. Proceedings

    International Nuclear Information System (INIS)

    Hohmeyer, O.; Ottinger, R.L.

    1994-01-01

    The social or external costs of energy have received a high degree of internatinal attention since the publication of the first empirical results in 1988. Possible global climate change and the call for a sustainable future of mankind have put the question of social costs onto the agenda of many national and international converences like the 'Earth Summit' in Rio 1992. A scientific discussion has been sparked off, searching for the best methodoligical approaches and reliable empirical data. An overview of this discussion was given by the report on the 1st international workshop published in 1991. This book reports on the 2nd international workshop on the subject and gives a broad overview of the discussion in the 25 papers presented. It is the most comprehensive picture of this subject matter avvailable. (orig.)

  13. Present status of the theoretical relativistic plasma SHF electronics

    International Nuclear Information System (INIS)

    Kuzelev, M.V.; Rukhadze, A.A.

    2000-01-01

    Paper presents a review of theoretical investigations into powerful sources of SHF waves grounded on the forced emission of relativistic electron beams in plasma wave guides and resonator. Emission sources operating under amplification of a certain inlet signal and under generation mode were studied. Two mechanisms of forced emission: resonance Cherenkov radiation of relativistic electron beams in plasma and nonresonance Pierce emission resulting from evolution of high-frequency Pierce instability, were studied. Paper discusses theoretical problems only, all evaluations and calculations are made for the parameters of the exact experiments, the theoretical results are compared with the available experimental data. Factors affecting formation of spectrum of waves excited by relativistic electron beam in plasma systems are discussed [ru

  14. The MQC experiment on Rome: Present status and future developments

    International Nuclear Information System (INIS)

    Cosmelli, C.

    1998-01-01

    The study of phenomena related to the quantum behavior of macroscopic systems is subjected to new efforts both from theoretical and experimental point of view. The validity in fact of the description of macroscopic systems given by Quantum Mechanics is still under test, especially for what concerns the macrorealistic interpretation of the real world and the influence of dissipation on quantum systems. Many groups tried in the last few years to realize an experimental set-up to perform an MQC experiment; the intrinsic dissipation however limited the possibility to fulfill the experimental requirements. The technology for realizing high quality Josephson Junctions is now so advanced that in principle the tests proposed in the last ten years can hopefully performed with success. In the following we will present a short description of the basic principles for an MQC experiment, with special emphasis on the experiment planned by the Rome group. (author)

  15. Present status of the Chimera-Isospin experiment

    International Nuclear Information System (INIS)

    Politi, G.; Arena, N.; Cardella, G.; DeFilippo, E.; Lanzano, G.; Nigro, S.L.; Pagano, A.; Papa, M.; Pirrone, S.; Russotto, P.; Alderighi, M.; Sechi, G.; Sperduto, M.L.; Amorini, F.; Anzalone, A.; Baran, V.; Bonasera, A.; Cavallaro, S.L.; Colonna, M.; Di Toro, M.; LaGuidara, E.; Lanzalone, G.; IaconoManno, M.; Giustolisi, F.; Maiolino, C.; Porto, F.; Rizzo, F.; Trifiro, A.; Trimarchi, M.; Auditore, L.; Barna, R.; DePasquale, D.; Berceanu, I.; Petrovici, M.; Pop, A.; Blicharska, J.; Grzeszczuk, A.; Kowalski, S.; Zipper, W.; Borderie, B.; LeNeindre, N.; Rivet, M.F.; Bougault, R.; Briczycnski, J.; Gawlikowicz, W.; Majka, Z.; Planeta, R.; Bruno, M.; D'Agostino, M.; Fuschini, E.; Geraci, E.; Vannini, G.; Chatterjee, M.B.; Chbihi, A.; Wieleczko, J.P.; Cibor, J.; Dayras, R.; Guazzoni, P.; Russo, S.; Sassi, M.; Zetta, L.; Guinet, D.; Li, S.; Wu, H.; Xiao, Z.; Nicolis, N.G.; Piasecki, E.; Swiderski, L.; Rosato, E.; Vigilante, M.; Wilczynski, J.; Siwek-Wilczynska, K.; Skwira, I.

    2003-01-01

    The CHIMERA detector was designed to significantly contribute to multifragmentation studies in the field of heavy ion collisions at intermediate energies. The device has been used at 'Laboratori Nazionali del Sud' (LNS) in Catania (Italy) to study different aspects of the relevant nuclear reaction mechanism, in two different campaigns: the first one in 2000, by using the forward part (1 - 30 degrees) of the device, and the second one in 2003, by using the 4π geometry. The experimental results have confirmed the capability of the apparatus for good isotopic identification of light charged particles and light fragments (3< Z<10) in a wide angular detection range. The data analysis relative to the first 2000 campaign (REVERSE) is presently aimed to disentangle dynamical and equilibrium emission components in multifragmentation reactions and to learn more about the role of the isospin degree of freedom in asymmetric nuclear matter. Reduction of the data of the second campaign is still in progress. (authors)

  16. Status of marine pollution research in South Africa (1960-present).

    Science.gov (United States)

    Wepener, V; Degger, N

    2012-07-01

    The published literature on marine pollution monitoring research in South Africa from 1960 to present was evaluated. There has been a general decline in the number of papers from the 1980s and this can be linked to the absence of a marine pollution monitoring programme in South Africa. General trends observed were that contaminant exposure monitoring of metals predominates the research conducted to date. Monitoring results indicate that there has been a general decrease in metal concentrations in South African coastal waters and concentrations of metals and most organics in mussels are lower than in other industrialised nations. This is reflected in the general pristine nature and high biodiversity of the South African coastline. The establishment of a national marine pollution monitoring framework would stimulate marine pollution research. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Present Status of the JENDL Project (May, 2014)

    International Nuclear Information System (INIS)

    Iwamoto, Osamu; Yokoyama, Kenji

    2014-01-01

    The Japanese Nuclear Data Committee (JNDC) is a research committee for JAEA research activities. It has two subcommittees: Subcommittee on Nuclear Data and Subcommittee on Reactor Constants. The JENDL-4.0 Updated Files (JENDL-4.0u) have been produced to take care of errors which were found after the release of JENDL-4.0. The JENDL-4.0u includes the nuclides whose nuclear data partly revised from important and/or trivial error(s). Thirteen files for JENDL-4.0 were released in 2013. Benchmarking for fission reactor applications was done using test files of Gd-157 and Am-241, and an integral testing for Th-232 was done using KUCA critical experiments. The data which are not updated in JENDL-4.0 are continuously considered to be revised, especially for FP region nuclides. Evaluated results for 141,143 Pr, 121,123-126 Sb and 96,98-106 Ru were published. The R-matrix analysis for O-16 is in progress. For decommissioning of nuclear power plants, evaluation of activation cross sections was planned for 569 reactions with 309 nuclides and is in progress. Evaluated files for the 246 isotopes from H to Hf have been created. As the activity of High Energy Nuclear Data Evaluation WG, development of new JENDL Photonuclear Data File is in progress. Evaluation for 181 nuclides has been finished. A Symposium on Nuclear Data was held on 14-15 November 2013 at Research Institute of Nuclear Engineering, University of Fukui, Tsuruga-shi, with topics about Progress in neutron cross-section measurement and analysis, Application of Nuclear Data, Recent topics, and Progress in studies of high-energy nuclear reaction. A total of 37 papers including 23 poster presentations were presented

  18. Cyanobacterial hydrogenases and biohydrogen: present status and future potential

    International Nuclear Information System (INIS)

    Lindblad, P.; Tamagnini, P.

    2000-01-01

    Molecular hydrogen (H 2 ) is an environmentally clean energy-carrier that may be a valuable alternative to the limited fossil fuel resources of today. For photobiological H 2 production, photosynthetic cyanobacteria are among the ideal candidates since they have the simplest nutritional requirements: they can grow in air (N 2 and CO 2 ), water (electrons and reductant), and mineral salts with light (solar energy) as the only source of energy. In N 2 -fixing cyanobacteria, H 2 is mainly produced by nitrogenases, but its partial consumption is quickly catalyzed by a unidirectional uptake hydrogenase. In addition, a bidirectional (reversible) enzyme may also oxidize some of the molecular hydrogen. The same enzyme will, under certain conditions, evolve H 2 Filamentous cyanobacteria have been used in bioreactors for the photobiological conversion of water to hydrogen. However, the conversion efficiencies achieved are low because the net H 2 production is the result of H 2 evolution via a nitrogenase and H 2 consumption mainly via an uptake hydrogenase. Consequently, the improvements of the conversion efficiencies are achieved e.g. through the optimization of the conditions for H 2 evolution by nitrogenase, through the production of mutants deficient in H 2 uptake activity and by an increased H 2 -evolution by a bidirectional enzyme. Symbiotic cells are of fundamental interest since they in situ 'function as a bioreactor', High metabolism, transfer of metabolite(s) from symbiont to host but almost no growth. In the present communication we will present the general knowledge about hydrogen metabolism/hydrogenases in filamentous cyanobacteria focusing on recent advances using molecular techniques, outline strategies for improving the capacity of H 2 -production by filamentous strains, and stress the importance of international cooperations and networks. (author)

  19. Nasopharyngeal carcinoma. Clinical diagnosis, external radiotherapy and brachytherapy. Status of the art in 2001

    International Nuclear Information System (INIS)

    Eschwege, F.; Bourkhis, J.; El Gueddari, B.

    2001-01-01

    Nasopharynx carcinomas (NPC) are a very special head and neck cancer, in term of epidemiology, clinic and pathology. Endemic disease in South East Asia, undifferentiated nasopharynx carcinoma are very frequent CT scan and NMR allow a better knowledge of the modalities of the clinical presentation. Prognostic factors include local and regional extension. NPC is a well known radiosensitive disease with a dose-response curve well established. Modern imaging modalities and modification of the ballistic explain the amelioration of the local control and the diminution of therapeutic sequelae. Brachytherapy is an interesting modalities for the boost and the treatment of recurrent disease. The exact place of 3 D CRT and IMRT is not yet known as modifications of fractionation. Local control for T1 T2 tumor is excellent but is related to clinical extension (cranial and neurologic involvement) and nodal extension (supra clavicular N3) and show the interest of combined chemo-radiotherapy protocols. (authors)

  20. Present status of research reactor decommissioning programme in Indonesia

    International Nuclear Information System (INIS)

    Suripto, A.; Mulyanto, N.

    2002-01-01

    At present Indonesia has 3 research reactors, namely the 30 MW MTR-type multipurpose reactor at Serpong Site, two TRIGA-type research reactors, the first one being 1 MW located at Bandung Site and the second one a small reactor of 100 kW at Yogyakarta Site. The TRIGA Reactor at the Bandung Site reached its first criticality at 250 kW in 1964, and then was operated at 1000 kW since 1971. In October 2000 the reactor power was successfully upgraded to 2 MW. This reactor has already been operated for 38 years. There is not yet any decision for the decommissioning of this reactor. However it will surely be an object for the near future decommissioning programme and hence anticipation for the above situation becomes necessary. The regulation on decommissioning of research reactor is already issued by the independent regulatory body (BAPETEN) according to which the decommissioning permit has to be applied by the BATAN. For Indonesia, an early decommissioning strategy for research reactor dictates a restricted re-use of the site for other nuclear installation. This is based on high land price, limited availability of radwaste repository site, and other cost analysis. Spent graphite reflector from the Bandung TRIGA reactor is recommended for a direct disposal after conditioning, without any volume reduction treatment. Development of human resources, technological capability as well as information flow from and exchange with advanced countries are important factors for the future development of research reactor decommissioning programme in Indonesia. (author)

  1. Present Status and Extensions of the Monte Carlo Performance Benchmark

    Science.gov (United States)

    Hoogenboom, J. Eduard; Petrovic, Bojan; Martin, William R.

    2014-06-01

    The NEA Monte Carlo Performance benchmark started in 2011 aiming to monitor over the years the abilities to perform a full-size Monte Carlo reactor core calculation with a detailed power production for each fuel pin with axial distribution. This paper gives an overview of the contributed results thus far. It shows that reaching a statistical accuracy of 1 % for most of the small fuel zones requires about 100 billion neutron histories. The efficiency of parallel execution of Monte Carlo codes on a large number of processor cores shows clear limitations for computer clusters with common type computer nodes. However, using true supercomputers the speedup of parallel calculations is increasing up to large numbers of processor cores. More experience is needed from calculations on true supercomputers using large numbers of processors in order to predict if the requested calculations can be done in a short time. As the specifications of the reactor geometry for this benchmark test are well suited for further investigations of full-core Monte Carlo calculations and a need is felt for testing other issues than its computational performance, proposals are presented for extending the benchmark to a suite of benchmark problems for evaluating fission source convergence for a system with a high dominance ratio, for coupling with thermal-hydraulics calculations to evaluate the use of different temperatures and coolant densities and to study the correctness and effectiveness of burnup calculations. Moreover, other contemporary proposals for a full-core calculation with realistic geometry and material composition will be discussed.

  2. Present status of the TJ-II remote participation system

    International Nuclear Information System (INIS)

    Vega, J.; Sanchez, E.; Lopez, A.; Portas, A.; Ochando, M.; Ascasibar, E.; Mollinedo, A.; Munoz, J.; Sanchez, A.; Ruiz, M.; Barrera, E.; Lopez, S.; Castro, R.; Lopez, D.

    2005-01-01

    The TJ-II remote participation system (RPS) was designed to extend to Internet the working capabilities provided in the TJ-II local environment, i.e., tracking the TJ-II operation, monitoring/programming data acquisition and control systems, and accessing databases. The TJ-II RPS was based on web and Java technologies because of their open character, security properties and technological maturity. A web server acts as a communication front-end between remote participants and local TJ-II elements. From the server side, web services are provided by means of resources supplied by JSP pages. The client part makes use of web browsers and ad hoc Java applications. The operation requires the use of a distributed authentication and authorization system. This development employs the PAPI System. At present, approximately 1000 digitisation channels can be managed from the TJ-II RPS. Furthermore, processing software based on a 4GL language (LabView) can be downloaded to multiprocessor data acquisition systems. Also, 15 diagnostic control systems, databases and the operation logbook are available from the RPS. The system even allows for the physicist in charge of operation to be in a remote location. Four Spanish universities make use of the TJ-II remote participation system capabilities for joint collaborations: these are the Universidad Politecnica de Madrid (UPM), Universidad Nacional de Educacion a Distancia (UNED), Universidad Complutense de Madrid (UCM) and Universidad Politecnica de Cataluna (UPC)

  3. Present status of application of AI in nuclear industry

    International Nuclear Information System (INIS)

    Kitamura, Masaharu

    1989-01-01

    Artificial intelligence (AL) techniques have been introduced actively in the nuclear industry in pursuit of increased safety and efficiency. The present report outlines some AI techniques currently used in nuclear facilities. This type of techniques have increasingly been introduced to such areas as design, construction, operation, maintenance, quality control and analysis. Most of them use knowledge engineering techniques including expert systems. Positive efforts at research and application of various more advance AI techniaues have started recently. For application of AI techniques, activities in nuclear power plants can be divided into two groups. One includes 'analytical' activities such as operation, maintenance and analysis, while the other includes 'synthetic' activities such as design, construction and fuel control. The most important AI technology for the analytical activities is diagnosis. Thus the report outlines major processes to which diagnostic techniques are applicable, and knowledge description and inference methods used for diagnosis. For AI techniques for synthetic activities, some problems and possible solutions are addressed. Development efforts in and outside Japan are also outlined. (Nogami, K.)

  4. Breast cancer screening in Japan. Present status and recent movement

    International Nuclear Information System (INIS)

    Endo, Tokiko

    2004-01-01

    As the incidence of breast cancer and deaths from breast cancer have been increasing, the Ministry of Public Welfare and Labor has been promoting breast cancer screening. Mammography screening began in fiscal year 2000 for those women 50 years of age or over, but attendance has not been increasing. This year (2004), the Ministry determined that mammography would be applicable to those 40 years of age or over and that screening with palpation alone would be abolished. To determine the effectiveness of the measures, mammography equipment, technologists, and readers were calculated. If the attendance were 50% of the 35,497 thousand women in this biennial screening, 40 persons would be examined by one apparatus per day, and, as there are 200 working days in a year, 1,109 apparatus would be needed. In the same way, if a technologist can examine 5,000 women, and a doctor can read 10,000 cases a year, both are apparently deficient in some prefectures. The standards of quality control for digital mammography have been determined by the Japan Radiological Society, and a ''step phantom for mammography'' has been developed. Qualitative evaluation of hard-copy clinical images has also started. All of the standards are presented in ''Mammography Guidelines, Second Edition,'' published by Igakushoin, Tokyo, Japan, 2004. (author)

  5. Present status and future aspects of highly precise radiotherapy

    International Nuclear Information System (INIS)

    Oita, Masataka; Takegawa, Yoshihiro; Maezawa, Hiroshi; Ikushima, Hitoshi; Osaki, Kyosuke; Nishitani, Hiromu

    2006-01-01

    This review describes about therapeutic equipments, irradiation technology, actual practice of highly precise radiotherapy (RT) and its tasks in future. Development of radiation equipments has made the therapy highly precise. At present, there are reportedly 836 linacs and 23 microtrons in Japan (March, 2005), most of which are computerized, new generation equipments. Image-guided RT, CT-linac system, real-time tumor-tracking RT (RTRT), tomotherapy and cyberknife are introduced owing to development of concerned devices and equipments. In addition, there are 7 facilities with proton and/or heavy ion beams. In parallel with the machine development above, irradiation has become to that from 2D to 3D by multi-gate technique with use of multi-leaf collimator and intensity-modulated RT is introduced. RTRT is an example of 4D RT. Practically, stereotactic irradiation (STI) to brain tumor has resulted in 1-year cumulative survival rate of 58% in 16 cases (23 foci, median size 1.2 cm and volume 0.57 ml) with median dose of 21.0 Gy in authors' hospital. STI in the early stage lung cancers is also practically conducted without severe adverse effects. Future tasks involve the further development of irradiation techniques and RT planning, QA/QC system, and raising of experts in related fields, which is a national problem. (T.I.)

  6. Present status and future possibilities of radioimmunoassay in animal production

    International Nuclear Information System (INIS)

    Karg, H.; Claus, R.; Hoffmann, B.; Schallenberger, E.; Schams, D.

    1976-01-01

    Radioimmunoassays and related isotope techniques have provided new possibilities in hormone analysis. Because of the new dimensions of sensitivity (nanogram and picogram range) it became possible to elucidate for many hormones their levels in peripheral blood plasma. Since some steps of the assay procedures could be automatized, and the evaluation computerized, the efficiency (for example, it is possible to run several thousand determinations weekly in one laboratory) can hardly be equalled by non-isotopic hormone analysis techniques. In animal husbandry the technique can be applied to mapping of physiological phenomena, diagnostic approaches in clinics, control of bio-techniques, residue studies of exogenous hormones, and attempts to use hormonal parameters as guide lines in connection with breeding programmes. The discovery that progesterone levels in milk reflect the corpus luteum function introduced far-reaching radioimmunoassay (RIA) application for fertility control under field conditions. With some other hormones, results of single determinations only allow limited interpretation because of different dynamics, for example releasing pattern, short-term (episodic, diurnal) and long-term (seasonal) variations and clearance properties. Furthermore, questions concerning the interactions between the actual plasma level of the hormone determined and the receptor sites in the target organ have to be solved. There are still gaps concerning the development of radioimmunoassays for important hormones. At present and in the foreseeable future of endocrinology in animal production, radioimmunoassays are indispensible. (author)

  7. China's spent fuel treatment: The present status and prospects

    International Nuclear Information System (INIS)

    Jiang Yunqing

    1999-01-01

    In the mid 1980s, China launched the development of nuclear power dominated by PWRs and opted for the closed fuel cycle strategy. On the basis of irradiated fuel reprocessing for defence purpose, an R and D programme for civil reprocessing has been implemented. Currently, China's spent fuel arising is limited but its amount will sharply increase with nuclear power expansion early next century. Spent fuel stored at reactor site for at least 5 years will be transported either by a combination of sea and rail or by road directly to the Lanzhou Nuclear Fuel Complex. A wet centralized storage facility with a 550 tHM capacity has been built for interim storage of spent fuel. Also, a multi-purpose reprocessing pilot plant with a maximum throughput of 400 kg HM/d is now under construction and will be put into commissioning by the turn of the century. A large-scale commercial reprocessing plant, perhaps with a capacity of 800 tHM/a, will be set up around 2020. Recovered uranium and plutonium from reprocessing will go to a demonstration plant and be manufactured into MOX fuel for FBR and PWR. The defence radwaste from reprocessing is at present being conditioned into the proper forms and will be disposed in appropriate repositories. All expertise and experience gained from these practices will be utilized in the future civil radwaste management. (author)

  8. Present status of standards relating to radiation control and protection

    International Nuclear Information System (INIS)

    Minami, Kentaro

    1996-01-01

    Japanese and international standards related to radiation control and radiation protective management are presented focusing on the forming condition, significance, current situation, and their relationship. Japanese Industrial Standards (JIS) is quite useful in the field of atomic energy as well as other fields in terms of optimization and rationalization of the management. JIS includes JIS Z 4001 Atomic Energy Terminology which corresponds to internationl standards ISO 921 Nuclear Glossary, and JIS Z 4005 Medical Radiation Terminology, covering about 500 articles, which corresponds to IEC 788 Medical Radiology-Terminology. The first standards regarding radiation protection was established in X-ray Film Badge, which is included in the field of personal dosimeter, in 1956. Currently, 36 JIS has been established in the field of radiation management dosimeter and 3 are under arrangement. As for radiation protective supplies, 9 JIS has been established so far. Before proposal of JIS, investigation had been conducted to improve, simplify, and standardize the standards of radiation dosimetric technique, dosimeters, dosimetric procedures, and improvement. In this article, the results of material surface contamination monitoring and body surface monitoring conducted in Atomic Energy Safety Association and Radiation Dosimetry Associationare reported, and ISO and IEC are also treated. (S.Y.)

  9. Present status of tritium research activities at universities in Japan

    International Nuclear Information System (INIS)

    Kawamura, K.

    1983-01-01

    The behaviours of tritium towards various materials are very similar to those of hydrogen, since tritium is one of the hydrogen isotope. In addition to those properties, tritium shows the radiochemical and radiological reactivities due to an emitted #betta#-ray. The permeability of tritium through various materials is the example of the former. The formation of tritiated methane in tritium stored in stainless steel vessels and the increase of helium content in tritium-bearing metallic materials are the examples of the latter. For these reasons, advanced and somewhat more complicated techniques are required for handling tritium. After the Ministry of Education, Science and Culture (MOE) made an appropriation on Grant-in-Aid for Fusion Research in 1975 year's budget, development of tritium handling technology for fusion reactors have been actively pursued. The specific experiments to be embodied in present research activities are: 1. Measurements of tritium permeation rate through various materials. 2. Fundamental studies on tritium containment materials. 3. Fundamental studies of tritium waste treatment and storage. In this paper, the works achieved under the above research activities are described and some results obtained from experiments are reported. (author)

  10. Present status of the Chimera-Isospin experiment

    Energy Technology Data Exchange (ETDEWEB)

    Politi, G.; Arena, N.; Cardella, G.; DeFilippo, E.; Lanzano, G.; Nigro, S.L.; Pagano, A.; Papa, M.; Pirrone, S.; Russotto, P. [Catania Univ., INFN (Italy); Alderighi, M.; Sechi, G.; Sperduto, M.L. [Milano Univ., INFN, CNR (Italy); Amorini, F.; Anzalone, A.; Baran, V.; Bonasera, A.; Cavallaro, S.L.; Colonna, M.; Di Toro, M.; LaGuidara, E.; Lanzalone, G.; IaconoManno, M.; Giustolisi, F.; Maiolino, C.; Porto, F.; Rizzo, F.; Trifiro, A.; Trimarchi, M. [Catania Univ., INFN, Lab. Nazionali del Sud (Italy); Auditore, L.; Barna, R.; DePasquale, D. [Messina Univ., INFN (Italy); Berceanu, I.; Petrovici, M.; Pop, A. [Inst. for Physics and Nuclear Engineering, Bucharest (Romania); Blicharska, J.; Grzeszczuk, A.; Kowalski, S.; Zipper, W. [Univ. of Silesia, Inst. of Physics, Katowice (Poland); Borderie, B.; LeNeindre, N.; Rivet, M.F. [Paris-11 Univ., IPN-IN2P3-CNRS, 91 - Orsay (France); Bougault, R. [Caen Univ., LPC-ISMRA (France); Briczycnski, J.; Gawlikowicz, W.; Majka, Z.; Planeta, R. [M. Smoluchowski Inst. of Physics, Jagellonian Univ., Cracow (Poland); Bruno, M.; D' Agostino, M.; Fuschini, E.; Geraci, E.; Vannini, G. [Bologna Univ., INFN (Italy); Chatterjee, M.B. [Saha Inst. of Nuclear Physics, NIS Div., Kolkata (India); Chbihi, A.; Wieleczko, J.P. [GANIL -CEA-IN2P3-CNRS, 14 - Caen (France); Cibor, J. [H.Niewodniczanski Inst. of Nuclear Physics, Cracow (Poland); Dayras, R. [CEA Saclay, Dept. d' Astrophysique, de Physique des Particules, de Physique Nucleaire et de l' Instrumentation Associee, SPhN, 91- Gif sur Yvette (France); Guazzoni, P.; Russo, S.; Sassi, M.; Zetta, L. [Milano Univ., INFN (Italy); Guinet, D. [Univ. Claude Bernard, IPN-IN2P3-CNRS, 69 - Lyon (France); Li, S.; Wu, H.; Xiao, Z. [Inst. of Modern Physics, Lanzhou (China); Nicolis, N.G. [Ioannina Univ., Dept. of Physics (Greece); Piasecki, E.; Swiderski, L.; Siwek-Wilczynska, K.; Skwira, I. [Warsaw Univ., Inst. for Experimental Physics (Poland); Rosato, E.; Vigilante, M.; Wilczynski, J.

    2003-07-01

    The CHIMERA detector was designed to significantly contribute to multifragmentation studies in the field of heavy ion collisions at intermediate energies. The device has been used at 'Laboratori Nazionali del Sud' (LNS) in Catania (Italy) to study different aspects of the relevant nuclear reaction mechanism, in two different campaigns: the first one in 2000, by using the forward part (1 - 30 degrees) of the device, and the second one in 2003, by using the 4{pi} geometry. The experimental results have confirmed the capability of the apparatus for good isotopic identification of light charged particles and light fragments (3presently aimed to disentangle dynamical and equilibrium emission components in multifragmentation reactions and to learn more about the role of the isospin degree of freedom in asymmetric nuclear matter. Reduction of the data of the second campaign is still in progress. (authors)

  11. History and present status of field application of radiotracers, (2)

    International Nuclear Information System (INIS)

    Koyama, Takeo; Shimizu, Makoto.

    1988-01-01

    In the field of agriculture, radiotracers were first used in 1957 in studies for improvement in fertilizing techniques. Techniques were established for accurate measurement of extremely low radioactivity in crops and for the separate determination of the phosphorus in crops of the fertilizer origin and soil origin. Then, RI or stable isotope tracing test methods were developed using 32 P or 15 N to determine the flow and absorption of fertilizers. Other techniques using radiotracers developed in this period served for the construction of maps of the root activity of crops, investigation of the effects of different fertilizers in farms where double-cropping was practised, identification of suitable fertilizers for orange cultivation, development of new fertilizing techniques for Japanese persimmon cultivation, etc. Practically, no field use of radiotracers has been found since 1970. At present, it is prohibited and replaced by other techniques using stable isotopes, etc. In the field fishery, radiotracers have been used for studies of various dynamic phenomena including the flow of water and deposits in the sea, behaviors of fish, food, chain, circulation of chemical substances in the ecological system, etc. (Nogami, K.)

  12. Present status and future perspective of development of atomic energy

    International Nuclear Information System (INIS)

    Takuma, Masao

    1990-01-01

    The last year was the 50th year from the discovery of the nuclear fission of uranium in 1939. The utilization of atomic energy made the unfortunate start as atomic bombs, but after the 'Atoms for Peace' declaration of President Eisenhauer, it has become to contribute to the development of mankind as nuclear power generation and radiation utilization. In Japan, the Atomic Energy Act was instituted in 1955, and the utilization of atomic energy has been eagerly promoted. As to nuclear power generation, as of the end of June, 1989, 423 power plants were in operation in the world, which generated 333 million kW, equivalent to 17 % of the total generated electric power. The nuclear power plants under construction and at planning stage were 199 with 190 million kW capacity, in this way, the development is advanced actively. At present in Japan, 38 nuclear power plants are in operation, generating 29.46 million kW, which has reached 30 % of the total generated electric power. The social environment surrounding atomic energy and the basic way of thinking on atomic energy development are discussed. The demand and supply of electric power in 21st century and atomic energy, and the policy of electric power companies to cope with it are explained. (K.I.)

  13. Present status of low-Z coating development in JAERI

    International Nuclear Information System (INIS)

    Nakamura, K.; Abe, T.; Obara, K.; Murakami, Y.

    1986-01-01

    In the JT-60 at JAERI, TiC-coated molybdenum and TiC-coated Inconel tiles are currently used as plasma interactive components. They have already been subjected to initial ohmic heating experiments and exhibited good adhesion characteristics under high heat flux conditions. The present article reviews a JAERI's coating development program for JT-60 experiments currently under way and for the next-step experiments. The program includes development and performance tests of the TiC-coated tiles, development of an in-situ coating technique for the repair of damaged surface of the tiles, and research on carbonization. Stress is laid on thermal shock and thermal fatigue tests of these coatings. In the thermal tests, adhesion between low-Z coatings and bulk materials have been investigated under high heat irradiation. TiC and TiN are used as coating material while Mo and Inconel 625 are employed as bulk material. Results are shown in this report concerning calculated temperature elavation of TiC/TiN/Mo due to hydrogen beam irradiation. As regards the irradiation time required for the melting of the substrate, experimental results mostly agree with calculations. Almost all coatings investigated are not exfoliated from the substrate until the melting of the substrate. (Nogami, K.)

  14. Present status of nuclear power safety studies in JAERI

    International Nuclear Information System (INIS)

    1989-01-01

    Japan Atomic Energy Research Institute carries out the safety research required for ensuring safety accompanying the development and utilization of atomic energy, dividing the roles with industrial circules, universities and other public research institutes. First, it carries out the research based on the yearly program of safety research, in which the subjects of safety research that the state should execute are decided. Next, it carries out a series of the safety verification test on atomic energy facilities entrusted by the state using the special account for power source development promotion countermeasures. Besides, it carries out the safety research on the specific subjects entrusted by outside organizations. The object and range of atomic energy safety at present are roughly divided into four fields, that is, nuclear power stations, nuclear fuel facilities, waste treatment and disposal, and environmental radioactivity. In order to advance the research effectively, in addition to the generalization department and the execution department, various committees are organized. In 1988, about 260 persons engaged in these four research fields, and the budget for fiscal year 1988 was about 17.4 billion yen. (K.I.)

  15. Present status of operation of the ETE spherical tokamak

    International Nuclear Information System (INIS)

    Bosco, E. del; Berni, L.A.; Ferreira, J.G.; Oliveira, R.M.; Ludwig, G.O.; Shibata, C.S.

    2005-01-01

    The ETE is a spherical tokamak with aspect ratio A = 1.5 (major radius of 0.3m and minor radius of 0.2m) under development at LAP/INPE. The ETE incorporates some innovative features that resulted in a compact and light weighted device with good plasma accessibility. Since the first plasma obtained at the very end of 2000 (Ip = 12kA, duration of 2ms, B o = 0.1T), the machine is operational and improvements are being done in order to achieve the planned final parameter values for the first phase of operation (Ip = 220kA, duration 15ms, B o = 0.4T), which are limited by the available capacitors. The efforts are being focused on incrementing the energy of the capacitor banks, lessening the stray magnetic fields in the plasma region, conditioning the vacuum vessel wall, implementing diagnostics and optimizing the discharge parameters. Presently, plasma currents in the range of 40-60kA (duration of 6-12 ms) are routinely obtained. Electron temperatures up to 160eV and plasma densities up to 3.0x10 19 m -3 are being reached. (author)

  16. Agriculturally important microbial biofilms: Present status and future prospects.

    Science.gov (United States)

    Velmourougane, Kulandaivelu; Prasanna, Radha; Saxena, Anil Kumar

    2017-07-01

    Microbial biofilms are a fascinating subject, due to their significant roles in the environment, industry, and health. Advances in biochemical and molecular techniques have helped in enhancing our understanding of biofilm structure and development. In the past, research on biofilms primarily focussed on health and industrial sectors; however, lately, biofilms in agriculture are gaining attention due to their immense potential in crop production, protection, and improvement. Biofilms play an important role in colonization of surfaces - soil, roots, or shoots of plants and enable proliferation in the desired niche, besides enhancing soil fertility. Although reports are available on microbial biofilms in general; scanty information is published on biofilm formation by agriculturally important microorganisms (bacteria, fungi, bacterial-fungal) and their interactions in the ecosystem. Better understanding of agriculturally important bacterial-fungal communities and their interactions can have several implications on climate change, soil quality, plant nutrition, plant protection, bioremediation, etc. Understanding the factors and genes involved in biofilm formation will help to develop more effective strategies for sustainable and environment-friendly agriculture. The present review brings together fundamental aspects of biofilms, in relation to their formation, regulatory mechanisms, genes involved, and their application in different fields, with special emphasis on agriculturally important microbial biofilms. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Present exploration status of the Lianshanguan uranium deposit, Northeast China

    International Nuclear Information System (INIS)

    Fei, Q.; Shaokang, H.

    1980-01-01

    During recent years surface radiometry has revealed a series of anomalies and uranium occurrences in the Lianshanguan region of Northeast China which are present in Proterozoic Formations. Several significant uranium occurrences were tested by trenching and core drilling which resulted in the discovery of the Lianshanguan uranium deposit in 1978. The ore bodies of economic significance are located at a depth of 38-250m. Potential reserves are 1000 tons of U 3 O 8 . The geological setting of the Lower Proterozoic Lianshanguan uranium deposit has a certain similarity to the Alligator Rivers Region, Northern Territory, Australia. However, the Lianshanguan deposit occurs in detrital formations (in the lower part of the Lower Proterozoic sequence), adjacent to a migmatitic zone; it is overlain by carbonate argillitic rocks. The discovery of the Lianshanguan deposit indicates a potential for further uranium discoveries in northeast China, where Proterozoic sequences are well developed. The Lianshanguan uranium deposit is located approximately 100km south of Shenyang at 40 0 59'N and 123 0 30'E

  18. Present status of food irradiation and trend of its development

    International Nuclear Information System (INIS)

    Maha, Munsiah

    1998-01-01

    Food irradiation has been studied, tested and evaluated intensively for more than 40 years, and at present, this technology has been taking-off for commercial use in many countries. Some 40 countries have approved its application for various food items on groups of food, and about 60 commercial irradiators have been providing irradiation service for food in 29 countries. In 1983, Codex General Standard for Irradiated Food with average irradiation dose limit not exceeding 10 kGy. The latest WHO press release on September 1997 stated that the maximum 10 kGy limit should not be there, since scientific evidences indicated that food irradiated even up to 75 kGy was safe to be consumed, as long as the sensory quality was acceptable and pathogenic organisms had been killed. The development of food irradiation in advanced countries, especially in USA is very significant lately, and hopefully this will be followed by other countries. In Indonesia, application of this technology has been approved since 1987, and six items or groups of food have been cleared for commercial irradiation. Further development and introduction of the technology are still needed to widen its application and to increase public awareness through harmonization of regulations among countries and dissemination of information. In addition, irradiation techniques for some specific purpose using either low dose, medium or high doses should be established to support effective, efficient and economical application. (author)

  19. The IFVE accelerating-storage complex (Present status)

    International Nuclear Information System (INIS)

    Balbekov, V.I.; Dmitrevski, Yu.P.; Kurnaev, O.V.

    1979-01-01

    A description of an accelerating-storage complex and the results of the development of its preliminary design are given. The first stage of the complex is a proton synchrotron with a standard electromagnet intended for storage and preliminary acceleration of protons to 400 GeV. Acceleration to 3 TeV will be provided by the second stage which is assumed to employ a superconducting magnet with 5 T. The existing 70 GeV synchrotron will be used as an injector. The magnetic structures of the first and second stages are identical. They include 180 FODO-type periods. Every period contains 12 dipoles and 2 quadrupole lenses. The accelerating devices should provide a total voltage amplitude of 12 MV or the superconducting ring. Three extraction modes are envisaged: a singleturn mode, a slow resonance extraction (during 30 s), and a fast resonance extraction of ten 1 ms pulses at 3 s intervals (6x10 13 protons per pulse). At present the preparation for testing 1 m long superconducting dipoles, HF systems, input and output devices is being completed. Measures aimed at suppressing the space charge effect are described. A possibility is investigated of obtaining 6 TeV by realizing proton-antiproton colliding beams in the complex by using the electron cooling method

  20. Present status of radiation application on irradiation service

    International Nuclear Information System (INIS)

    Watanabe, Hiroshi

    2006-01-01

    Presently, it is in operation 6 gamma-ray facilities and 5 electron beam (EB) facilities for an irradiation service. New gamma-ray facility is under construction, and will be worked in August this year. These facilities are generally employed for crosslinking and decomposition of polymers, graft polymerization, improvement of semiconductor properties, sterilization of medical devices, laboratory-animals feed, packing materials and biotechnological devices. As for being feature one of EB facilities is employed only for improvement of polymers and semiconductors. Approximately 91% of gamma-ray sterilization of medical devices is processed in house, and 5 facilities are working in 4 firms. Other two firms have 4 EB facilities for sterilization. Therefore, the degree of dependence of irradiation service is low in the sterilization of medical devices. About 50% of medical devices are still sterilized by ethylene oxide gas (EOG). However, a part of laws has been amended successively from 5 years ago, and the regulation of EOG handling became harsh. Therefore, EOG sterilization will be gradually displaced in radiation sterilization. On the other hand, demand for sterilization of the packing materials has increased significantly, and various kinds of packing materials in food industry are sterilized by both gamma-rays and EB. Currently, novel PMMA dosimeter was developed and named Radix W. The dosimeter allows measurement of doses from 1 kGy to 150 kGy without influence of dose rates and irradiation temperature. The activities of irradiation service probably will continue to increase over future. (author)

  1. Present status and extensions of the Monte Carlo performance benchmark

    International Nuclear Information System (INIS)

    Hoogenboom, J.E.; Petrovic, B.; Martin, W.R.

    2013-01-01

    The NEA Monte Carlo Performance benchmark started in 2011 aiming to monitor over the years the abilities to perform a full-size Monte Carlo reactor core calculation with a detailed power production for each fuel pin with axial distribution. This paper gives an overview of the contributed results thus far. It shows that reaching a statistical accuracy of 1 % for most of the small fuel zones requires about 100 billion neutron histories. The efficiency of parallel execution of Monte Carlo codes on a large number of processor cores shows clear limitations for computer clusters with common type computer nodes. However, using true supercomputers the speedup of parallel calculations is increasing up to large numbers of processor cores. More experience is needed from calculations on true supercomputers using large numbers of processors in order to predict if the requested calculations can be done in a short time. As the specifications of the reactor geometry for this benchmark test are well suited for further investigations of full-core Monte Carlo calculations and a need is felt for testing other issues than its computational performance, proposals are presented for extending the benchmark to a suite of benchmark problems for evaluating fission source convergence for a system with a high dominance ratio, for coupling with thermal-hydraulics calculations to evaluate the use of different temperatures and coolant densities and to study the correctness and effectiveness of burnup calculations. Moreover, other contemporary proposals for a full-core calculation with realistic geometry and material composition will be discussed. (authors)

  2. The High Flux Reactor Petten, present status and prospects

    Energy Technology Data Exchange (ETDEWEB)

    Ahlf, J [Institute for Advanced Materials, Joint Research Centre, Petten (Netherlands)

    1990-05-01

    The High Flux Reactor (HFR) in Petten, The Netherlands, is a light water cooled and moderated multipurpose research reactor of the closed-tank in pool type. It is operated with highly enriched Uranium fuel at a power of 45 MW. The reactor is owned by the European Communities and operated under contract by the Dutch ECN. The HFR programme is funded by The Netherlands and Germany, a smaller share comes from the specific programmes of the Joint Research Centre (JRC) and from third party contract work. Since its first criticality in 1961 the reactor has been continuously upgraded by implementing developments in fuel element technology and increasing the power from 20 MW to the present 45 MV. In 1984 the reactor vessel was replaced by a new one with an improved accessibility for experiments. In the following years also other ageing equipment has been replaced (primary heat exchangers, pool heat exchanger, beryllium reflector elements, nuclear and process instrumentation, uninterruptable power supply). Control room upgrading is under preparation. A new safety analysis is near to completion and will form the basis for a renewed license. The reactor is used for nuclear energy related research (structural materials and fuel irradiations for LWR's, HTR's and FBR's, fusion materials irradiations). The beam tubes are used for nuclear physics as well as solid state and materials sciences. Radioisotope production at large scale, processing of gemstones and silicon with neutrons, neutron radiography and activation analysis are actively pursued. A clinical facility for boron neutron capture therapy is being designed at one of the large cross section beam tubes. It is foreseen to operate the reactor at least for a further decade. The exploitation pattern may undergo some changes depending on the requirements of the supporting countries and the JRC programmes. (author)

  3. Radwaste disposal strategy in Bangladesh: Present status and future trends

    International Nuclear Information System (INIS)

    Jalil, A.; Rabbani, G.

    2002-01-01

    Significant amounts of radioactive solid liquid and mixed wastes are generated in Bangladesh from peaceful uses of atomic energy including disused sealed sources and spent fuel from the research reactor and other hot laboratories in the country. At present these wastes are being collected, segregated, labeled and stored in an interim safe storage. A Central Waste Processing and Storage Facility (CWPSF) is fast nearing completion in the Atomic Energy Research Establishment (AERE), Savar campus where the TRIGA Research Reactor, Isotope Production Laboratory, 14 MeV Neutron Generator, 37 x 10 2 TBq commercial irradiator and other hot facilities are situated. A national strategy exists for the management and disposal of various types of radioactive wastes. Gaseous and liquid wastes are discharged in the environment in a controlled manner following delay decay procedure. Short-lived low and intermediate level wastes (SL-LILW) and disused/spent sealed radioactive sources are being stored in an interim storage before storage in the CWPSF following short treatment and conditioning. As regards their disposal, the currently preferred option is engineered near surface repository. Site investigation work has progressed far enough toward the goal of establishing a demonstration repository at AERE, Savar by the year 2010. For small amount of long-lived highly active problem wastes including spent radium needles and disused radioactive sources, the safe management option is a long-term storage in the CWPSF after conditioning and treatment. But this is not considered as a sustainable solution. The real emphasis is placed on the development of inexpensive disposal methods and availing regional/international repositories. (author)

  4. The High Flux Reactor Petten, present status and prospects

    International Nuclear Information System (INIS)

    Ahlf, J.

    1990-01-01

    The High Flux Reactor (HFR) in Petten, The Netherlands, is a light water cooled and moderated multipurpose research reactor of the closed-tank in pool type. It is operated with highly enriched Uranium fuel at a power of 45 MW. The reactor is owned by the European Communities and operated under contract by the Dutch ECN. The HFR programme is funded by The Netherlands and Germany, a smaller share comes from the specific programmes of the Joint Research Centre (JRC) and from third party contract work. Since its first criticality in 1961 the reactor has been continuously upgraded by implementing developments in fuel element technology and increasing the power from 20 MW to the present 45 MV. In 1984 the reactor vessel was replaced by a new one with an improved accessibility for experiments. In the following years also other ageing equipment has been replaced (primary heat exchangers, pool heat exchanger, beryllium reflector elements, nuclear and process instrumentation, uninterruptable power supply). Control room upgrading is under preparation. A new safety analysis is near to completion and will form the basis for a renewed license. The reactor is used for nuclear energy related research (structural materials and fuel irradiations for LWR's, HTR's and FBR's, fusion materials irradiations). The beam tubes are used for nuclear physics as well as solid state and materials sciences. Radioisotope production at large scale, processing of gemstones and silicon with neutrons, neutron radiography and activation analysis are actively pursued. A clinical facility for boron neutron capture therapy is being designed at one of the large cross section beam tubes. It is foreseen to operate the reactor at least for a further decade. The exploitation pattern may undergo some changes depending on the requirements of the supporting countries and the JRC programmes. (author)

  5. A therapy for oral cancer. The present status and prospects of surgical therapy

    International Nuclear Information System (INIS)

    Fukutake, Kimio; Ohtsuru, Hiroshi

    1995-01-01

    Surgery for carcinoma of the oral cavity has developed rapidly with recent advances in reconstruction. Particularly, in radical surgery for progressive and recurrent disease, safe and adequate resection has been made possible and postoperative cosmetic and functional recovery has been achieved. We reviewed 64 patients with progressive and recurrent cancer who had undergone reconstruction using microvascular techniques during the 12 years from 1983 to 1994. There were 19 patients with T3 disease, 25 with T4 disease, and 20 with recurrence. The free grafts used were radial forearm flaps, the jejunum, rectus abdominis musculocutaneous flaps, and scapular flaps. The survival of free flap grafts was 95.3%. The primary tumor control rate was 85.9%, and the 5-year cumulative survival rate was 61.1%, 60.1%, and 62.9% for patients with T3, T4, and recurrent disease, respectively. Twelve patients with T4 disease of the tongue and the floor of the mouth were treated with combined preoperative brachytherapy and surgery to alleviate postoperative dysfunction, and this treatment was found to be exceedingly effective for improving the postoperative quality of life. There are still many problems with mandibular reconstruction. Since cancer patients commonly undergo preoperative radiotherapy, transplantation of living vascularized bone grafts is frequently performed and is believed to be effective. Since it is important to reconstruct masticatory function as well as to achieve cosmetic improvement, various techniques have recently been used to fit the reconstructed mandible with dental prostheses in order to restore masticatory function. This paper describes the present status and the prospects of surgical therapy for oral cancer. (author)

  6. Marital status and survival of patients with oral cavity squamous cell carcinoma: a population-based study

    OpenAIRE

    Shi, Xiao; Zhang, Ting-ting; Hu, Wei-ping; Ji, Qing-hai

    2017-01-01

    Background The relationship between marital status and oral cavity squamous cell carcinoma (OCSCC) survival has not been explored. The objective of our study was to evaluate the impact of marital status on OCSCC survival and investigate the potential mechanisms. Results Married patients had better 5-year cancer-specific survival (CSS) (66.7% vs 54.9%) and 5-year overall survival (OS) (56.0% vs 41.1%). In multivariate Cox regression models, unmarried patients also showed higher mortality risk ...

  7. Combined analysis of circulating epithelial cells and serum thyroglobulin for distinguishing disease status of the patients with papillary thyroid carcinoma

    OpenAIRE

    Lin, Hung-Chih; Liou, Miaw-Jene; Hsu, Hsung-Ling; Hsieh, Jason Chia-Hsun; Chen, Yi-An; Tseng, Ching-Ping; Lin, Jen-Der

    2015-01-01

    Papillary thyroid carcinoma (PTC) accounts for about 80% of the cases in thyroid cancer. Routine surveillance by serum thyroglobulin (Tg) and medical imaging is the current practice to monitor disease progression of the patients. Whether enumeration of circulating epithelial cells (CECs) helps to define disease status of PTC patients was investigated. CECs were enriched from the peripheral blood of the healthy control subjects (G1, n = 17) and the patients at disease-free status (G2, n = 26) ...

  8. TP53 mutation and human papilloma virus status of oral squamous cell carcinomas in young adult patients

    NARCIS (Netherlands)

    Braakhuis, B.J.M.; Rietbergen, M.M.; Buijze, M.; Snijders, P.J.F.; Bloemena, E.; Brakenhoff, R.H.; Leemans, C.R.

    2014-01-01

    Objective Little is known about the molecular carcinogenesis of oral squamous cell carcinoma (OSCC) in young adult patients. The aim of this study was to investigate the detailed TP53 mutation and human papilloma virus (HPV) status of OSCC in patients, younger than 45 years. Methods TP53 mutations

  9. Simultaneous meningioma and brain metastasis from renal cell carcinoma – a rare presentation. Case report

    Directory of Open Access Journals (Sweden)

    Aline Lariessy Campos Paiva

    2017-05-01

    Full Text Available ABSTRACT CONTEXT: Brain metastases are the most common tumors of the central nervous system. Because of their high frequency, they may be associated with rare situations. Among these are tumor-to-tumor metastasis and an even a rarer situation called simultaneous brain tumors, which are more related to primary tumors of the reproductive and endocrine systems. CASE REPORT: A 56-year-old male patient with a history of renal cell carcinoma (which had previously been resected presented with a ventricular lesion (suggestive of metastatic origin and simultaneous olfactory groove lesion (probably a meningioma. First, only the ventricular lesion was dealt with, but after a year, the meningothelial lesion increased and an occipital lesion appeared. Therefore, both of these were resected in a single operation. All the procedures were performed by the same neurosurgeon. The patient evolved without neurological deficits during the postoperative period. After these two interventions, the patient remained well and was referred for adjuvant treatment. CONCLUSIONS: This study provides the first description of an association between these two tumors. Brain metastases may be associated with several lesions, and rare presentations such as simultaneity with meningioma should alert neurosurgeons to provide the best oncological treatment.

  10. Painless lump over the forehead which turned painful: an unusual presentation of hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    S P Susheela

    2015-05-01

    Full Text Available Hepatocellular carcinoma (HCC is one of the most common malignancies and is known to most often present with symptomatology pertaining to local hepatic disease. Although HCC is known to metastasize to lungs, abdominal lymph nodes, adrenal glands and the vertebral column, it is rather rare to come across patients with skull metastasis. The manifestation of a solitary frontal bone metastasis leading to a painless lump over the forehead as the initial presenting feature of HCC is highly unusual. This case report pertains to a 40-year-old male patient who had initially observed a painless lump over his forehead that was gradually increasing in size over a span of 3 months. He sought medical attention when, after several months, the "painless lump" suddenly became painful. Investigations revealed the involvement of both the outer and the inner table of the frontal bone, and a biopsy revealed the histopathology to be that of HCC. On further investigation, he was found to have systemic disseminated disease involving both the left and right lungs and vertebrae and treatment was initiated with sorafenib. Despite an initial partial response, the patient subsequently succumbed to hepatic failure. This case report illustrates the fact that HCC can silently progress, and even lead to dissemination and distant metastases before becoming clinically evident.

  11. Osler-Weber-Rendu disease presenting with hepatocellular carcinoma: radiologic and genetic findings.

    Science.gov (United States)

    Lee, Joo Ho; Lee, Yung Sang; Kim, Pyo Nyun; Lee, Beom Hee; Kim, Gu Whan; Yoo, Han Wook; Heo, Nae Yun; Lim, Young Suk; Lee, Han Chu; Chung, Young Hwa; Suh, Dong Jin

    2011-12-01

    This is a case report of a 68-year-old man with hepatocellular carcinoma (HCC) accompanied by hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, and hepatic vascular malformation. HHT is an autosomal dominant disorder of the fibrovascular tissue that is characterized by recurrent epistaxis, mucocutaneous telangiectasias, and visceral arteriovenous malformations. HHT is caused by mutation of the genes involved in the signaling pathway of transforming growth factor-β, which plays an important role in the formation of vascular endothelia. Hepatic involvement has been reported as occurring in 30-73% of patients with HHT. However, symptomatic liver involvement is quite rare, and the representative clinical presentations of HHT in hepatic involvement are high-output heart failure, portal hypertension, nodular regenerative hyperplasia, and symptoms of biliary ischemia. Some cases of HCC in association with HHT have been reported, but are very rare. We present herein the characteristic radiologic and genetic findings of HHT that was diagnosed during the evaluation and treatment of HCC.

  12. Ductal carcinoma in situ: USC/Van Nuys Prognostic Index and the impact of margin status.

    Science.gov (United States)

    Silverstein, Melvin J; Buchanan, Claire

    2003-12-01

    As our knowledge of ductal carcinoma in situ (DCIS) continues to evolve, treatment decision-making has become increasingly complex and controversial for both patients and physicians. Treatment options include mastectomy, and breast conservation with or without radiation therapy. Data produced from the randomized clinical trials for DCIS has provided the basis for important treatment recommendations, but are not without limitations. In this article, we review our prospectively collected database consisting of 1036 patients with DCIS treated at the Van Nuys Breast Center and the USC/Norris Comprehensive Cancer Center. We review the use of the USC/Van Nuys Prognostic Index, a clinical algorithm designed to assist physicians in selection of appropriate treatments, and examine the impact of margin status as a sole predictor of local recurrence.

  13. Recent results on polarizations and the present status of the Fermilab polarized beams

    International Nuclear Information System (INIS)

    Yokosawa, Akihiko.

    1986-01-01

    Experimental results are reviewed on polarization phenomena in nucleon-nucleon scattering at intermediate energies. The present status of S = 0 dibaryon resonances is presented. The status of the Fermilab polarized beam program is presented, including the construction of polarized beam, two polarimeters being installed in the experimental hall, and the experimental program

  14. Rare presentation of a common disease: Idiopathic hypoparathyroidism presenting with extrapyramidal symptoms and status epilepticus

    Directory of Open Access Journals (Sweden)

    Kaushik Ghosh

    2012-01-01

    Full Text Available We report of an 18-year-old male who presented with an epileptiform disorder, features of hypocalcemia, and an extrapyramidal symptom in the form of choreoathetosis. On evaluation he had idiopathic hypoparathyroidism with extensive calcifications in the extrapyramidal system of the brain; basal ganglion, as well as in the cerebral cortex and cerebellum, which is a rare entity. We report the rare presentation of a common disorder, which requires to be considered in evaluating hypoparathyroidism.

  15. The computed tomographic findings of bronchogenic carcinoma presenting as a solitary peripheral pulmonary mass

    International Nuclear Information System (INIS)

    Kim, Hong; Kim, Ok Bae; Woo, Seong Ku; Suh, Soo Jhi; Kim, Sung Soo

    1985-01-01

    It is difficult to distinguish benign from malignant, ulmonary nodule by conventional roentgenologic examination. But CT makes it easier to evaluate adjacent parenchymal invasion, pleural or mediastinal extension, or early metastasis to intra- or extrathoracic lymph node as well as distant organs, although only a solitary peripheral pulmonary nodule is seen on plain radiograph. Authors reviewed CT of 22 cases of histopathologically confirmed primary lung cancer seen as a solitary peripheral pulmonary mass from May 1980 to September 1984 at Dongsan Medical Center, Keimyung University. The results are as follows: 1. The incidence was most common in the 6th decade (36%). Male to female ratio was 10 : 1 and 2 females all had bronchioloalveolar cell carcinoma. 2. The distribution of histologic cell type were as follows: squamous cell carcinoma 40%, adenocarcinoma, small cell carcinoma, bronchioloalveolar cell carcinoma and unclassified carcinoma 14% in each cases, and adenoid cystic carcinoma 4%. 3. The computed tomographic findings were as follows: a) Superior and posterior basal segments of both lower lobes were most frequently involved (68%). b) The mean diameter of the mass was 48 mm, and most common in the range of 30-49 mm in the greatest dimension (46%). c) The mean CT attenuation value was 57 H.U., and most common in the group of 41-70 H. U. (64%). d) Lymph node metastasis was found in 13 (59%) of 22 cases, and the involved nodes were as follows: hilar nodes 10 cases, paratracheal nodes 8 cases, subcarinal nodes 7 cases and extrathoracic nodes 3 cases. In 2 of 3 cases with small cell carcinoma, diffuse multiple lymph nodes were involved. e) Distant metastasis was seen relatively early in 3 cases: cerebral metastasis in 1 cases of squamous cell carcinoma, right adrenal metastasis without intrathoracic lymph node metastasis or invasion of adjacent structure in 1 case of bronchioloalveolar cell carcinoma, and liver and bone metastasis in 1 case of unclassified

  16. Presentation of Apocrine Breast Carcinoma in a Woman with Bilateral Silicone Prosthesis; Presentacion de un carcinoma apocrino de mama en una mujer con protesis bilateral de silicona

    Energy Technology Data Exchange (ETDEWEB)

    Alonso, J. A.; Salvador, R.; Salvador, M.; Barranco, C.

    2003-07-01

    We present a case of apocrine breast carcinoma in a 45 year-old woman with bilateral silicone breast prosthesis whose clinical manifestations and mammography were that of a palpable nodule-high glandular density, rounded and with imprecise borders devoid of any visible microcalcifications. A bibliographical revision confirmed the infrequent association of this type of tumor with the presence of silicone breast implants, precisely in which we consider its radiological interest to lie. (Author) 11 refs.

  17. Epstein-Barr Virus-Associated Lymphoepithelioma-Like Gastric Carcinoma Presenting as a Submucosal Mass: CT Findings with Pathologic Correlation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sang Won; Shin, Hyeong Cheol; Kim, Il Young; Kim, Chang Jin; Lee, Ji Hye; Lee, Chang Kyun; Jeong, Dong Jun [Soonchunhyang University Cheonan Hospital, Cheonan(Korea, Republic of)

    2010-12-15

    A lymphoepithelioma-like carcinoma, characterized by a carcinoma with heavy lymphocyte infiltration, is one of the histological patterns observed in patients with Epstein-Barr virus (EBV)-associated gastric carcinoma. Less than half of invasive carcinomas with lymphoepithelioma-like histology can grow to make a submucosal mass. These tumors generally have a better prognosis than conventional adenocarcinomas. We report a case of an EBV-associated lymphoepitheliomalike gastric carcinoma that presented as a submucosal mass on multi-detector (MD) CT and correlate them with the pathology

  18. Epstein-Barr Virus-Associated Lymphoepithelioma-Like Gastric Carcinoma Presenting as a Submucosal Mass: CT Findings with Pathologic Correlation

    International Nuclear Information System (INIS)

    Kim, Sang Won; Shin, Hyeong Cheol; Kim, Il Young; Kim, Chang Jin; Lee, Ji Hye; Lee, Chang Kyun; Jeong, Dong Jun

    2010-01-01

    A lymphoepithelioma-like carcinoma, characterized by a carcinoma with heavy lymphocyte infiltration, is one of the histological patterns observed in patients with Epstein-Barr virus (EBV)-associated gastric carcinoma. Less than half of invasive carcinomas with lymphoepithelioma-like histology can grow to make a submucosal mass. These tumors generally have a better prognosis than conventional adenocarcinomas. We report a case of an EBV-associated lymphoepitheliomalike gastric carcinoma that presented as a submucosal mass on multi-detector (MD) CT and correlate them with the pathology

  19. Stage Presentation, Care Patterns, and Treatment Outcomes for Squamous Cell Carcinoma of the Penis

    Energy Technology Data Exchange (ETDEWEB)

    Burt, Lindsay M.; Shrieve, Dennis C.; Tward, Jonathan D., E-mail: Jonathan.Tward@hci.utah.edu

    2014-01-01

    Purpose: Penile squamous cell carcinoma (SCC) is a rare entity, with few published series on outcomes. We evaluated the stage distributions and outcomes for surgery and radiation therapy in a U.S. population database. Methods and Materials: Subjects with SCC of the penis were identified using the National Cancer Institute Surveillance, Epidemiology and End Results (SEER) Program database between 1988 and 2006. Descriptive statistics were performed, and cause-specific survival (CSS) was estimated using Kaplan-Meier analysis. Comparisons of treatment modalities were analyzed using multivariate Cox regression. Subjects were staged using American Joint Committee on Cancer, sixth edition, criteria. Results: There were 2458 subjects identified. The median age was 66.8 years (range, 17-102 years). Grade 2 disease was present in 94.5% of cases. T1, T2, T3, T4, and Tx disease was present in 64.8%, 17.1%, 9.5%, 2.1%, and 6.5% of cases, respectively. N0, N1, N2, N3, and Nx disease was noted in 61.6%, 6.9%, 4.0%, 3.7%, and 23.8% of cases, respectively. M1 disease was noted in 2.5% of subjects. Individuals of white ethnicity accounted for 85.1% of cases. Lymphadenectomy was performed in 16.7% of cases. The CSS for all patients at 5 and 10 years was 80.8% and 78.6%. By multivariable analysis grades 2 and 3 disease, T3 stage, and positive lymph nodes were adverse prognostic factors for CSS. Conclusion: SCC of the penis often presents as early-stage T1, N0, M0, grade 1, or grade 2 disease. The majority of patients identified were treated with surgery, and only a small fraction of patients received radiation therapy alone or as adjuvant therapy.

  20. When is bacterial vaginosis not bacterial vaginosis?--a case of cervical carcinoma presenting as recurrent vaginal anaerobic infection.

    OpenAIRE

    Hudson, M M; Tidy, J A; McCulloch, T A; Rogstad, K E

    1997-01-01

    Vaginal anaerobic infection is the most common cause of vaginal discharge in women. We present a case of recurrent vaginal anaerobic infection and cervical carcinoma and discuss the association of the two conditions. More frequent cytology/colposcopy may be indicated in women who give a history of recurrent or persistent vaginal anaerobic infection.

  1. HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy

    International Nuclear Information System (INIS)

    McAlpine, Jessica N; Gilks, C Blake; Miller, Dianne M; Wiegand, Kimberly C; Vang, Russell; Ronnett, Bridgett M; Adamiak, Anna; Köbel, Martin; Kalloger, Steve E; Swenerton, Kenneth D; Huntsman, David G

    2009-01-01

    The response rate of ovarian mucinous carcinomas to paclitaxel/carboplatin is low, prompting interest in targeted molecular therapies. We investigated HER2 expression and amplification, and the potential for trastuzumab therapy in this histologic subtype of ovarian cancer. HER2 status was tested in 33 mucinous carcinomas and 16 mucinous borderline ovarian tumors (BOT)). Five cases with documented recurrence and with tissue from the recurrence available for testing were analyzed to determine whether HER2 amplification status changed over time. Three prospectively identified recurrent mucinous ovarian carcinomas were assessed for HER2 amplification and patients received trastuzumab therapy with conventional chemotherapy. Amplification of HER2 was observed in 6/33 (18.2%) mucinous carcinomas and 3/16 (18.8%) BOT. HER2 amplification in primary mucinous carcinomas was not associated with an increased likelihood of recurrence. The prospectively identified recurrent mucinous carcinomas showed overexpression and amplification of HER2; one patient's tumor responded dramatically to trastuzumab in combination with conventional chemotherapy, while another patient experienced an isolated central nervous system recurrence after trastuzumab therapy. HER2 amplification is relatively common in ovarian mucinous carcinomas (6/33, 18.2%), although not of prognostic significance. Trastuzumab therapy is a treatment option for patients with mucinous carcinoma when the tumor has HER2 amplification and overexpression

  2. Breast abscess as the initial manifestation of primary pure squamous cell carcinoma: a rare presentation and literature review.

    Science.gov (United States)

    Salemis, Nikolaos S

    2011-01-01

    Primary squamous cell carcinoma of the breast is a very rare tumor accounting for less than 0.4% of all breast cancers. Fewer than 100 cases have been reported in the literature so far. The diagnosis requires strict pathologic criteria to be fulfilled. Due to the rarity of this tumor the optimal treatment and prognosis are both unclear. Breast abscess as the initial presentation of a primary squamous cell breast carcinoma is an extremely rare clinical entity. In this study, we describe a case of a 61-year-old postmenopausal woman who presented with typical manifestations of a breast abscess and was diagnosed with a pure primary squamous cell breast carcinoma. Diagnostic evaluation and management of the patient are discussed along with a review of the literature. Despite its rarity, the possibility of a primary pure squamous cell breast carcinoma should always be considered in the differential diagnosis in postmenopausal patients presenting with manifestations of a breast abscess, especially in those who respond poorly to the initial treatment. Physicians should be aware of this rare malignancy in order to avoid delays in diagnosis and treatment.

  3. Present status on atomic and molecular data relevant to fusion plasma diagnostics and modeling

    International Nuclear Information System (INIS)

    Tawara, H.

    1997-01-01

    This issue is the collection of the paper presented status on atomic and molecular data relevant to fusion plasma diagnostics and modeling. The 10 of the presented papers are indexed individually. (J.P.N.)

  4. Prevalence of the integration status for human papillomavirus 16 in esophageal carcinoma samples.

    Science.gov (United States)

    Li, Shuying; Shen, Haie; Li, Ji; Hou, Xiaoli; Zhang, Ke; Li, Jintao

    2018-03-01

    To investigate the etiology of esophageal cancer (EC) related with human papillomavirus (HPV) infection. Fresh surgically resected tissue samples and clinical information were obtained from 189 patients. Genomic DNA was extracted, and HPV was detected using polymerase chain reaction (PCR) with HPV L1 gene primers of MY09/11; HPV16 was detected using HPV16 E6 type-specific primer sets. Copies of HPV16 E2, E6, and the human housekeeping gene β-actin were tested using quantitative PCR to analyze the relationship between HPV16 integration and esophageal squamous cell carcinoma and the relationship between the HPV16 integration status and clinical information of patients. Of the 189 samples, 168 HPV-positive samples were detected, of which 76 were HPV16 positive. Among the HPV16 positive samples, 2 cases (E2/E6 ratio>1) were 2.6% (2/76) purely episomal, 65 (E2/E6 ratio between 0 and 1) were 85.6% (65/76) mixture of integrated and episomal, and 9 (E2/E6 ratio=0) were 11.8% (9/76) purely integrated. The results indicate that integration of HPV16 was more common in the host genome than in the episome genome. The prevalence rate of HPV16 integration is increasing with the pathological stage progression of esophageal carcinoma (EC). A high prevalence of HPV16 suggested that HPV16 has an etiological effect on the progress of EC. Integration of HPV16 is more common than episome genome in the host cells, indicating that continuous HPV infection is the key to esophageal epithelial cell malignant conversion and canceration.

  5. Impact of Margin Status on Local Recurrence After Mastectomy for Ductal Carcinoma In Situ

    International Nuclear Information System (INIS)

    Childs, Stephanie K.; Chen, Yu-Hui; Duggan, Margaret M.; Golshan, Mehra; Pochebit, Stephen; Punglia, Rinaa S.; Wong, Julia S.; Bellon, Jennifer R.

    2013-01-01

    Purpose: To examine the rate of local recurrence according to the margin status for patients with pure ductal carcinoma in situ (DCIS) treated by mastectomy. Methods and Materials: One hundred forty-five consecutive women who underwent mastectomy with or without radiation therapy for DCIS from 1998 to 2005 were included in this retrospective analysis. Only patients with pure DCIS were eligible; patients with microinvasion were excluded. The primary endpoint was local recurrence, defined as recurrence on the chest wall; regional and distant recurrences were secondary endpoints. Outcomes were analyzed according to margin status (positive, close (≤2 mm), or negative), location of the closest margin (superficial, deep, or both), nuclear grade, necrosis, receptor status, type of mastectomy, and receipt of hormonal therapy. Results: The primary cohort consisted of 142 patients who did not receive postmastectomy radiation therapy (PMRT). For those patients, the median follow-up time was 7.6 years (range, 0.6-13.0 years). Twenty-one patients (15%) had a positive margin, and 23 patients (16%) had a close (≤2 mm) margin. The deep margin was close in 14 patients and positive in 6 patients. The superficial margin was close in 13 patients and positive in 19 patients. One patient experienced an isolated invasive chest wall recurrence, and 1 patient had simultaneous chest wall, regional nodal, and distant metastases. The crude rates of chest wall recurrence were 2/142 (1.4%) for all patients, 1/21 (4.8%) for those with positive margins, 1/23 (4.3%) for those with close margins, and 0/98 for patients with negative margins. PMRT was given as part of the initial treatment to 3 patients, 1 of whom had an isolated chest wall recurrence. Conclusions: Mastectomy for pure DCIS resulted in a low rate of local or distant recurrences. Even with positive or close mastectomy margins, the rates of chest wall recurrences were so low that PMRT is likely not warranted

  6. Preoperative Controlling Nutritional Status (CONUT) Score for Assessment of Prognosis Following Hepatectomy for Hepatocellular Carcinoma.

    Science.gov (United States)

    Takagi, Kosei; Yagi, Takahito; Umeda, Yuzo; Shinoura, Susumu; Yoshida, Ryuichi; Nobuoka, Daisuke; Kuise, Takashi; Araki, Hiroyuki; Fujiwara, Toshiyoshi

    2017-09-01

    Immune-nutritional status has been recently reported as a prognostic factor in hepatocellular carcinoma (HCC). The controlling nutritional status (CONUT) score has been established as a useful tool to evaluate immune-nutritional status. This study aimed to investigate the efficacy of the CONUT score as a prognostic factor in patients undergoing hepatectomy for HCC. A total of 295 patients who underwent curative hepatectomy for HCC between January 2007 and December 2014 were retrospectively analyzed. Patients were divided into two groups according to the CONUT score. The impact of the CONUT score on clinicopathological, surgical, and long-term outcomes was evaluated. Subsequently, the impact of prognostic factors, including the CONUT score, associated with outcomes was assessed using multivariate analyses. Of 295 patients, 118 (40%) belonged to the high CONUT group (CONUT score ≥ 3). The high CONUT group had a significantly lower 5-year recurrence-free survival rate than the low CONUT group (27.9 vs. 41.4%, p = 0.011) and a significantly lower 5-year overall survival rate (61.9 vs. 74.9%, p = 0.006). In multivariate analyses of prognostic factors, the CONUT score was an independent predictor of recurrence-free survival (hazard ratio = 1.64, p = 0.006) and overall survival (hazard ratio = 2.50, p = 0.001). The CONUT score is a valuable preoperative predictor of survival in patients undergoing hepatectomy for HCC.

  7. Jejunal metastases from squamous cell carcinoma of the cervix presenting as an abdominal wall abscess

    Directory of Open Access Journals (Sweden)

    Kavita Mardi

    2016-01-01

    Full Text Available Metastatic tumors of the intestinal tract from extra-abdominal sites are rare. In cervical cancer, the liver, lung, and the bones are the most common distant sites of metastases. Metastasis to the small intestine is very rare. We report a rare case of metastasis of cervical squamous cell carcinoma to jejunum after a few months of chemoradiotherapy.

  8. Multi cranial nerve palsies as the presenting features of prostate carcinoma

    International Nuclear Information System (INIS)

    Mitchell, D.M.; Wynne, C.J.; Cowan, I.

    2008-01-01

    Full text: Cranial nerve palsies have previously been reported in metastatic prostate carcinoma, usually occurring late in the course of the disease. We describe the case of a 55-year-old man whose diagnosis of prostate cancer was made following investigation of multiple cranial nerve palsies.

  9. Incidental versus non-incidental thyroid carcinoma: Clinical presentation, surgical management and prognosis.

    Science.gov (United States)

    González-Sánchez-Migallón, Elena; Flores-Pastor, Benito; Pérez-Guarinos, Carmen Victoria; Miguel-Perelló, Joana; Chaves-Benito, Asunción; Illán-Gómez, Fátima; Carrillo-Alcaraz, Andrés; Aguayo-Albasini, José Luis

    2016-11-01

    Thyroid cancer may be clinically evident as a tumor mass in the neck or as a histopathological incidental finding after thyroid surgery for an apparent benign condition. Our objective was to assess the differences in clinical signs, surgical management, and course between incidental and clinically diagnosed thyroid tumors. A retrospective study was conducted on patients operated on for benign or malignant thyroid disease from January 2000 to March 2014. Among the 1415 patients who underwent any thyroid surgery, 264 neoplasms were found, of which 170 were incidental. A comparison was made of incidental versus non-incidental carcinomas. Among incidental carcinomas, cases whose indication for surgery was Graves' disease were compared to those with multinodular goiter. Incidental carcinomas were in earlier stages and required less aggressive surgery. There were no differences in surgical complications between incidental and clinical tumors, but mortality and relapses were markedly higher in non-incidental cancers (4.4% vs 0% and 13.2% vs 4.8% respectively). Carcinomas developing on Graves' disease showed no differences from all other incidental tumors in terms of complications, mortality, or relapse after surgery. Early stage thyroid cancer has better survival and prognosis after surgical treatment. Copyright © 2016 SEEN. Publicado por Elsevier España, S.L.U. All rights reserved.

  10. Cutaneous squamous cell carcinoma presenting as a wound with discharging sinus tracts in a wild African lion (Panthera leo).

    Science.gov (United States)

    Mwase, M; Mumba, C; Square, D; Kawarai, S; Madarame, H

    2013-11-01

    A female wild African lion (Panthera leo) was presented with an 8-month history of a wound with multiple discharging sinus tracts on the left paw. Microscopical examination revealed squamous cell carcinoma (SCC). To the best of our knowledge, this is the first report of cutaneous SCC in an African lion. Cutaneous SCC presenting as discharging sinus tracts lined by neoplastic squamous cells has not been reported previously in animals. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. Status epilepticus as the only presentation of the neonatal Bartter syndrome

    Directory of Open Access Journals (Sweden)

    Soumya Patra

    2012-01-01

    Full Text Available Bartter syndrome is a rare hereditary (autosomal recessive salt-losing tubulopathy characterized by hypokalemia, hypochloremia, metabolic alkalosis, and normal blood pressure with hyperreninemia, The underlying renal abnormality results in excessive urinary losses of sodium, chloride, and potassium. We report a case of a four-month-old infant with neonatal Bartter syndrome, who presented only with status epilepticus. To the best of our present knowledge, there is no reported case of Bartter syndrome who presented with status epilepticus.

  12. Status epilepticus as the only presentation of the neonatal Bartter syndrome.

    Science.gov (United States)

    Patra, Soumya; Konar, Mithun C; Basu, Rajarshi; Khaowas, Ajoy K; Dutta, Soumyadeep; Sarkar, Debanjali

    2012-03-01

    Bartter syndrome is a rare hereditary (autosomal recessive) salt-losing tubulopathy characterized by hypokalemia, hypochloremia, metabolic alkalosis, and normal blood pressure with hyperreninemia, The underlying renal abnormality results in excessive urinary losses of sodium, chloride, and potassium. We report a case of a four-month-old infant with neonatal Bartter syndrome, who presented only with status epilepticus. To the best of our present knowledge, there is no reported case of Bartter syndrome who presented with status epilepticus.

  13. Carcinoma microsatellite instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for stage II rectal cancer.

    Science.gov (United States)

    Yang, Liu; Sun, Yan; Huang, Xin-En; Yu, Dong-Sheng; Zhou, Jian-Nong; Zhou, Xin; Li, Dong-Zheng; Guan, Xin

    2015-01-01

    Rectal cancers with high microsatellite-instable have clinical and pathological features that differentiate them from microsatellite-stable or low- frequency carcinomas, which was studied rarely in stage II rectal cancer, promoting the present investigation of the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II rectal cancer. Data of 460 patients who underwent primary anterior resection with a double stapling technique for rectal carcinoma at a single institution from 2008 to 2012 were retrospectively collected. All patients experienced a total mesorectal excision (TME) operation. Survival analysis were analyzed using the Cox regression method. Five-year rate of disease-free survival (DFS) was noted in 390 (84.8%) of 460 patients with stage II rectal cancer. Of 460 tissue specimens, 97 (21.1%) exhibited high-frequency microsatellite instability. Median age of the patients was 65 (50-71) and 185 (40.2%) were male. After univariate and multivariate analysis, microsatellite instability (p= 0.001), female sex (pchemotherapy (pchemotherapy, those cancers displaying high-frequency microsatellite instability had a better 5-year rate of DFS than tumors exhibiting microsatellite stability or low-frequency instability (HR, 13.61 [95% CI, 1.88 to 99.28]; p= 0.010), while in 259 patients who received adjuvant chemotherapy, there was no DFS difference between the two groups (p= 0.145). Furthermore, patients exhibiting microsatellite stability or low-frequency instability who received adjuvant chemotherapy had a better 5-year rate of DFS than patients did not (HR, 5.16 [95% CI, 2.90 to 9.18]; pchemotherapy and gender. Fluorouracil-based adjuvant chemotherapy benefits patients of stage II rectal cancer with microsatellite-stable or low microsatellite-instable, but not those with high microsatellite- instable. Additionally, free of adjuvant chemotherapy, carcinomas with high microsatellite

  14. Risk of second breast cancers after lobular carcinoma in situ according to hormone receptor status.

    Directory of Open Access Journals (Sweden)

    Kai Mao

    Full Text Available Although subsequent breast cancer risk after primary lobular carcinoma in situ (LCIS has been studied intensively, whether the risk of second breast cancer after first LCIS varies with hormone receptor (HR status of primary tumor remains unclear.We identified 10,304 women with primary pure unilateral LCIS between 1998 and 2007 from the Surveillance, Epidemiology and End Results (SEER 18 Registries. Kaplan-Meier estimates of 5 or 10-year probabilities of second ipsilateral breast cancers (IBCs and contralateral breast cancers (CBCs were calculated. Multivariable Cox proportional model was performed to identify impact of HR status of primary LCIS, and other demographic, clinicopathologic or treatment characteristics on risk of second IBCs or CBCs.Of the 10,304 women with primary LCIS included in this study, 9949 (96.5% patients had HR+ tumors, and 355 (3.5% had HR- tumors. Multivariable-adjusted analyses showed that although there was no difference in risk of total second IBCs between women with HR+ and HR- LCIS (P = 0.152, patients with HR+ LCIS had a statistically lower risk of second invasive IBCs compared to those with HR- LCIS (hazard ratio 0.356, 95% CI 0.141-0.899, P = 0.029. Women with primary HR+ LCIS had lower risks of both second total and invasive CBCs compared to those with HR- LCIS (total CBCs: hazard ratio 0.340, 95% CI 0.228-0.509, P<0.001; invasive CBCs: hazard ratio 0.172, 95% CI 0.108-0.274, P<0.001. Additionally, black women had a 2-fold risk of developing subsequent total IBCs than white women (P = 0.028.This population-based study demonstrated that the risk of second breast cancers was significantly increased in women with HR- first LCIS compared to those with HR+ LCIS. These findings warrant intensive surveillance for second breast cancers in HR- LCIS survivors.

  15. Mucoepidermoid carcinoma ex pleomorphic adenoma of the lacrimal gland: A rare presentation

    Directory of Open Access Journals (Sweden)

    Lily Daniel

    2014-01-01

    Full Text Available Carcinoma ex pleomorphic adenoma in lacrimal gland is a rare entity unlike its salivary gland counterpart. This rare tumor poses a diagnostic challenge to clinicians as pre-operative diagnosis is difficult and diagnosis is only by careful pathological assessment. We report this uncommon lesion in a 62-year-old lady, wherein the malignant component was mucoepidermoid carcinoma. The elderly patient remained clinically and radiologically free of the tumor for two years after complete excision of the tumor but computed tomography at the end of two and a half years showed a recurrent lesion in the region of the lacrimal gland. This makes long term follow up of patients with these rare lacrimal tumors imperative with a minimum period of at least five years.

  16. Evaluation of oxidative stress status and antioxidant capacity in patients with renal cell carcinoma.

    Science.gov (United States)

    Aldemir, Mustafa; Karaguzel, Ersagun; Okulu, Emrah; Gudeloglu, Ahmet; Ener, Kemal; Ozayar, Asim; Erel, Ozcan

    2015-01-01

    We evaluated and compared the serum oxidative stress and antioxidant enzymes in patients with renal cell carcinoma (RCC) and the control group. The prospective study consisted of 97 patients with RCC (Group 1) and 80 age and sex matched healthy volunteers (Group 2). Group 1 and 2 were compared concerning serum mean total oxidant status (TOS), total antioxidant capacity (TAC), paraoxonase-1 (PON-1), arylesterase, total thiol, catalase (CAT), myeloperoxidase (MPO) and ceruloplasmin. Patients' mean age was 58.5 ±12.3 and 56.9 ±15.8 years, respectively, in Group 1 and 2. No statistically significant differences were detected between the groups in terms of oxidative stress parameters and antioxidant capacity measured in the serum of patients including, TOS, TAC, PON1, arylesterase, total thiol, CAT, MPO, and ceruloplasmin levels (p >0.05 for all parameters). The PON-1 value was significantly higher in patients with pT1 stage than pT3 stage (p = 0.007). The arylesterase value was significantly higher in patients with Fuhrman's nuclear grade 3 than grade 2 (p = 0.035). There was no correlation between these parameters level and Fuhrman's nuclear grade, stage, or histopathological tumor type. Our results demonstrated that evaluation of these parameters in the serum of patients with localized RCC may not be used as a marker to discriminate between patients with RCC and healthy people.

  17. Socioeconomic status and esophageal squamous cell carcinoma risk in Kashmir, India.

    Science.gov (United States)

    Dar, Nazir A; Shah, Idrees A; Bhat, Gulzar A; Makhdoomi, Muzamil A; Iqbal, Beenish; Rafiq, Rumaisa; Nisar, Iqra; Bhat, Arshid B; Nabi, Sumaiya; Masood, Akbar; Shah, Sajad A; Lone, Mohd M; Zargar, Showkat A; Islami, Farhad; Boffetta, Paolo

    2013-09-01

    Studies have persistently associated esophageal squamous cell carcinoma (ESCC) risk with low socioeconomic status (SES), but this association is unexplored in Kashmir, an area with a high incidence of ESCC in the northernmost part of India. We carried out a case-control study to assess the association of multiple indicators of SES and ESCC risk in the Kashmir valley. A total number of 703 histologically confirmed ESCC cases and 1664 controls matched to the cases for age, sex, and district of residence were recruited from October 2008 to January 2012. Conditional logistic regression models were used to calculate unadjusted and adjusted odds ratios and 95% confidence intervals. Composite wealth scores were constructed based on the ownership of several appliances using multiple correspondence analyses. Higher education, living in a kiln brick or concrete house, use of liquefied petroleum gas and electricity for cooking, and higher wealth scores all showed an inverse association with ESCC risk. Compared to farmers, individuals who had government jobs or worked in the business sector were at lower risk of ESCC, but this association disappeared in fully adjusted models. Occupational strenuous physical activity was strongly associated with ESCC risk. In summary, we found a strong relationship of low SES and ESCC in Kashmir. The findings need to be studied further to understand the mechanisms through which such SES parameters increase ESCC risk. © 2013 Japanese Cancer Association.

  18. Osler-Weber-Rendu disease presenting with hepatocellular carcinoma: radiologic and genetic findings

    OpenAIRE

    Lee, Joo Ho; Lee, Yung Sang; Kim, Pyo Nyun; Lee, Beom Hee; Kim, Gu-Whan; Yoo, Han-Wook; Heo, Nae-Yun; Lim, Young-Suk; Lee, Han Chu; Chung, Young-Hwa; Suh, Dong Jin

    2011-01-01

    This is a case report of a 68-year-old man with hepatocellular carcinoma (HCC) accompanied by hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, and hepatic vascular malformation. HHT is an autosomal dominant disorder of the fibrovascular tissue that is characterized by recurrent epistaxis, mucocutaneous telangiectasias, and visceral arteriovenous malformations. HHT is caused by mutation of the genes involved in the signaling pathway of transforming growth f...

  19. Unusual presentation of anaplastic thyroid carcinoma with diffuse neck and thoracic nodules and hyperthyroidism

    Directory of Open Access Journals (Sweden)

    Yun-Hsuan Lin

    2017-06-01

    Full Text Available Anaplastic thyroid carcinoma (ATC is a highly aggressive endocrine tumor that can be expected to have a poor clinical outcome. Cutaneous metastases from ATC are rare and in the context of disseminated metastases. Owing to the rarity of the disease, no standard treatment has been documented, and few treatment modalities are effective. This case reports neck and thoracic cutaneous metastasis from ATC, with concurrent hyperthyroidism.

  20. Synchronous gastric and duodenal metastases from head and neck squamous cell carcinoma: a unique presentation of upper gastrointestinal bleeding.

    Science.gov (United States)

    Tarangelo, Nicholas P; Kistler, C Andrew; Daitch, Zachary; Jiang, Wei; Quirk, Daniel M

    2018-01-01

    Metastatic disease to the stomach or duodenum is an infrequent diagnosis, and head and neck squamous cell carcinoma (HNSCC) is one of the least common primary malignancies that lead to gastric or duodenal metastases. We report the case of a 65-year-old man with human immunodeficiency virus infection and previously diagnosed HNSCC who presented with melena. The patient had a percutaneous endoscopic gastrostomy tube placed 3 months prior to his presentation. Laboratory testing was significant for normocytic anemia and a digital rectal examination was positive for melena. Esophagogastroduodenoscopy revealed numerous cratered nodules with contact bleeding in the stomach as well as the duodenum that appeared malignant. Biopsies of the gastric and duodenal nodules were positive for p40 and CK 5/6, consistent with metastatic squamous cell carcinoma.

  1. Lymphangiogenesis in breast carcinoma is present but insufficient for metastatic spread

    Directory of Open Access Journals (Sweden)

    Mirsad Dorić

    2014-04-01

    Full Text Available Introduction: The lymphatic vasculature is an important route for the metastatic spread of human cancer. However, the extent to which this depends on lymphangiogenesis or on invasion of existing lymph vessels remains controversial. The goal of this study was to investigate the existence of lymphangiogenesis in invasive breast carcinoma: by measuring the lymphatic vessels density (LVD and lymphatic endothelial cell proliferation (LECP and their correlation with various prognostic parameters in breast cancer, including lymphovascular invasion (LVI.Methods: Lymphatic vessels density was investigated in 75 specimens of invasive breast carcinoma by immunostaining for D2-40 using the Chalkley counting method. Endothelial proliferation in lymphatic vessels was analyzed by dual-color immunohistochemistry with D2-40 and Ki-67.Results: Decrease of intra and peritumoral LVD in invasive breast carcinoma compared to fibrocystic breast disease was detected (p=0.002. Lymphatic endothelial cell proliferation was significantly higher in invasive breast cancer (p=0.008 than in the fibrocystic breast disease. LECP showed a correlation with histological grade of the tumor (p=0.05. Involvement of axillary lymph nodes with metastatic tissue was in strong correlation only with existence of lymphatic vascular invasion (p=0.0001.Conclusion: These results suggest that development of breast cancer promotes proliferation of lymphatic endothelial cells whose level correlates with histological grade of tumor, but in a scope that is insufficient to follow growth of tumor tissue that invades them and destruct them. This might explain the decrease of lymphatic vessels density.

  2. Basaloid carcinoma of the pancreas--clinicopathological presentation and oncogenetic snapshot of a rare entity.

    Science.gov (United States)

    Szasz, A Marcell; Szirtes, Ildiko; Tihanyi, Balazs; Barkaszi, Bernadett; Baranyai, Zsolt; Tihanyi, Tibor; Harsanyi, Laszlo; Timar, Jozsef; Kulka, Janina

    2015-02-01

    We report a case of basaloid pancreatic carcinoma with clinical, pathological, and genomic data. The 73-year-old male patient had jaundice, acholic stool, diarrhea, weight loss, and a large, painless gall bladder. His GGT was highly elevated. The pancreatic head contained a tumor, which was resected by partial pancreatoduodenectomy with pancreato-gastric anastomosis, cholecystectomy, and lymphadenectomy. On gross examination, a 3.8-cm white firm nodule was found, which microscopically was composed of basaloid cell nests with a less than usual desmoplastic stromal background and focally PANIN. Immunohistochemical profile displayed strong CK5/6, CK19, p63, EGFR, vimentin, and evident CK14 expression and absence of expression of CK7, chromogranin, synaptophysin, and BRCA1. A high Ki-67 index and p53 expression were noted. Sequencing of the most frequent 46 oncogenes with ionTorrent (AmpliSeq PCR) method identified PIK3CA, KRAS, and TP53 genes as drivers and variants of the FGFR3, PDGFRA, KIT, KDR, EGFR, RET, and ATM genes. The tumor we report displays histopathological appearances similar to the previously described case and a genomic landscape fitting to the general population of pancreatic carcinomas. We hypothesize that this tumor may belong to the group of DNA damage repair-deficient pancreatic carcinoma subgroup.

  3. Histological, Immunohistological, and Clinical Features of Merkel Cell Carcinoma in Correlation to Merkel Cell Polyomavirus Status

    Directory of Open Access Journals (Sweden)

    T. Jaeger

    2012-01-01

    Full Text Available Merkel cell carcinoma is a rare, but highly malignant tumor of the skin with high rates of metastasis and poor survival. Its incidence rate rises and is currently about 0.6/100000/year. Clinical differential diagnoses include basal cell carcinoma, cyst, amelanotic melanoma, lymphoma and atypical fibroxanthoma. In this review article clinical, histopathological and immunhistochemical features of Merkel cell carcinoma are reported. In addition, the role of Merkel cell polyomavirus is discussed.

  4. Presentations

    International Nuclear Information System (INIS)

    2007-01-01

    The PARIS meeting held in Cracow, Poland from 14 to 15 May 2007. The main subjects discussed during this meeting were the status of international project dedicated to gamma spectroscopy research. The scientific research program includes investigations of giant dipole resonance, probe of hot nuclei induced in heavy reactions, Jacobi shape transitions, isospin mixing and nuclear multifragmentation. The mentioned programme needs Rand D development such as new scintillations materials as lanthanum chlorides and bromides as well as new photo detection sensors as avalanche photodiodes - such subjects are also subjects of discussion. Additionally results of computerized simulations of scintillation detectors properties by means of GEANT- 4 code are presented

  5. Transitional Cell Carcinoma of the Upper Ureter Metastatic to the Thoracic Spine Presenting as a Spinal Cord Compression

    Directory of Open Access Journals (Sweden)

    J. O. Larkin

    2008-01-01

    Full Text Available We performed a left nephroureterectomy for a gentleman with transitional cell carcinoma of the upper ureter. Histological analysis revealed it to be a T1 lesion, but to be highly mitotically active. The gentleman defaulted on adjuvant therapy and defaulted on follow-up. He represented with symptoms of acute spinal cord compression and magnetic resonance imaging demonstrated a lesion at T6/7. Neurosurgical resection of the lesion showed it to be a metastatic deposit from the ureteric primary. Despite surgical debulking and subsequent radiotherapy to the lesion, the patient died secondary to metastatic complications. This case report is of interest to the surgeon as it demonstrates both the high metastatic potential of upper tract carcinomas and educates the surgeon on the presentation of acute spinal cord compression.

  6. Sinonasal carcinoma presenting as chronic sinusitis and sequential bilateral visual loss

    Directory of Open Access Journals (Sweden)

    Wei-Yu Chiang

    2015-01-01

    Full Text Available Sinonasal undifferentiated carcinoma-related rhinogenic optic neuropathy is rare and may lead to visual loss. To the best of our knowledge, this is the first report of bilateral sequential visual loss induced by this etiology. It is important to differentiate between chronic sinusitis and malignancy on the basis of specific findings on magnetic resonance images. Surgical decompression with multidisciplinary therapy, including steroids, chemotherapy, and radiotherapy, is indicated. However, no visual improvement was noted in this case, emphasizing the rapid disease progression and importance of early diagnosis and treatment.

  7. Molecular alterations in early gastric carcinomas. No apparent correlation with Helicobacter pylori status

    NARCIS (Netherlands)

    Blok, P.; Craanen, M. E.; Offerhaus, G. J.; Dekker, W.; Kuipers, E. J.; Meuwissen, S. G.; Tytgat, G. N.

    1999-01-01

    Data on the differences in molecular profile between H pylori-positive and H pylori-negative early gastric carcinomas, if any, are almost nonexistent. We therefore investigated whether molecular differences can be observed between H pylori-positive and H pylori-negative early gastric carcinomas.

  8. Radiation sterilization of medical supplies: conceptions, regulations, present status and further developments

    International Nuclear Information System (INIS)

    Peteu, Gh.

    1994-01-01

    A general view on the present stage and tendencies in the development of radiation sterilization of biomedical supplies is presented. Specific concepts in correlation with some regulations of the World Health Organization and of the National Public Health Authorities concerning the present state, the possibilities and criteria of development in our country, are discussed. Finally the present status of the design and execution of the project of two mobile and multipurpose irradiators is presented. (Author)

  9. Safety analysis of the present status of the research reactor 'RA' at 'Vinca' Institute

    International Nuclear Information System (INIS)

    Jovic, V.; Jovic, L.; Zivotic, Z.; Milovanovic, Dj.

    1995-01-01

    Safety analysis of the nuclear facility which has been out of work for a long time and whose future is not defined at the present moment, can not be connected to the usual, normatively regulated system analysis procedure in both operational and accidental regimes. Therefore, the safety analysis of the present status of the present status of the reactor RA is related to system and components analysis which, in present conditions maintain their nuclear functions operational. In the first place, it refers to components and equipment in which radioactive radiation generation still exists and to installations and equipment maintaining radiation level below permitted limit. in the context of the analysis the following areas are being covered: present status characteristics, accidental events while operating period from 1959. to 1984., nuclear fuels and radioactive waste inventory, basic characteristics and status of safety-related systems and equipment, radiation protection, potential accident analysis at present status of the reactor RA, potential accidental situations due to natural events (earthquakes, water flood) or man-induced events and security. 8 refs

  10. Present status of accelerator-based BNCT: Focus on developments in Argentina

    International Nuclear Information System (INIS)

    Cartelli, D.; Capoulat, M.E.; Bergueiro, J.; Gagetti, L.; Suárez Anzorena, M.; Grosso, M.F. del; Baldo, M.; Castell, W.; Padulo, J.; Suárez Sandín, J.C.; Igarzabal, M.; Erhardt, J.; Mercuri, D.

    2015-01-01

    In this work we provide some information on the present status of accelerator-based BNCT (AB-BNCT) worldwide and subsequently concentrate on the recent accelerator technology developments in Argentina. - Highlights: • The current status of projects and associated facilities for AB-BNCT worldwide is shown. • Only low (few MeV) energy accelerators are included. • The recent progress of the Argentine AB-BNCT program is described.

  11. Primary merkel cell carcinoma clinically presenting as deep oedematous mass of the groin

    Directory of Open Access Journals (Sweden)

    Gambichler T

    2010-06-01

    Full Text Available Abstract Merkel cell carcinoma (MCC is a relatively rare, polyomavirus associated, primary neuroendocrine carcinoma of the skin which is usually arising from dermal skin layers. However, the origin of MCC in the subcutaneous tissue is debatable. We report a 58-yearold female patient with an oedematous mass on her left groin that was firm in consistency and had no discoloration or other visible abnormality of the overlying skin. On histology and immunohistology the tumour was consistent with the diagnosis of MCC showing a predominant subcutanous growth pattern. Pelvic magnetic resonance tomography revealed a tumour conglomerate reaching from the subcutis of the left groin to the left paraaortal and parailiacal region indicating widespread lymphogenic metastisation. Despite complete medical work-up no other MCC primary could be detected. In conclusion, predominant subcutaneous growth pattern as well as tumour localization in the groin are uncommon features of MCC. MCC showing the aforementioned features may be associated with significant delay of diagnosis and therefore represents an unfavourable prognostic factor.

  12. Initial Presentation of Renal Cell Carcinoma as a Metastatic Mass within the Masseter Muscle: A Case Report and Literature Review

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Kyung Eun; Lee, Han Bee; Cho, Woo Ho; Kim, Jae Hyung; Lee, Ji Hae; Kang, Min Jin [Dept. of Radiology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Kim, Hyun Jung [Dept. of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of)

    2012-02-15

    Renal cell carcinoma (RCC) is often concomitant with distant metastasis, and these metastases are the first sign of an otherwise occult primary. Whereas metastasis of RCC to the head and neck has been reported, metastasis to the masseter muscle, which is composed of skeletal muscle, is quite rare. We now report the case of a 66-year-old man who had a past history of pulmonary tuberculosis, with RCC metastasis of a well-defined intensely enhancing hypervascular mass in the masseter muscle as the initial presentation. We present the imaging findings of this case and a literature review about radiologic differential diagnosis of intramasseteric masses.

  13. Historical review, present status and perspectives of nuclear sciences education at the Sofia University

    International Nuclear Information System (INIS)

    Djingova, R.; Kuleff, I.; Todorovsky, D.; Kovacheva, P.; Tsankov, L.; Staevski, K.; Tsenov, R.

    2004-01-01

    A brief review of the history of the education in nuclear sciences at the Faculty of Physics and Faculty of Chemistry of the Sofia University is made in the report. The present status of Bachelor, Master and PhD programmes in both Faculties is presented. (authors)

  14. Nuclear power in the world: Its present status and development trends

    International Nuclear Information System (INIS)

    Bennett, L.L.

    1994-01-01

    Present status of nuclear power development in the world is presented showing data on power reactors in operation and under construction, on growth of nuclear electricity generation since 1970, the distribution of nuclear electricity generation during 1993. Development trends in the field are also outlined. 7 figs, 5 tabs

  15. Present status and prospect of the experimental study of QED in high Z ions

    International Nuclear Information System (INIS)

    Briand, J.P.

    1993-01-01

    I summarize in this paper the present status of our experimental knowledge on the Lamb shift of high Z hydrogenlike ions. Some tentative prospect on the future improvements with the new large accelerators and ion sources are discussed and compared with the present accuracy of QED corrections. (orig.)

  16. Prognostic impact of controlling nutritional status score in resected lung squamous cell carcinoma.

    Science.gov (United States)

    Toyokawa, Gouji; Kozuma, Yuka; Matsubara, Taichi; Haratake, Naoki; Takamori, Shinkichi; Akamine, Takaki; Takada, Kazuki; Katsura, Masakazu; Shimokawa, Mototsugu; Shoji, Fumihiro; Okamoto, Tatsuro; Maehara, Yoshihiko

    2017-09-01

    The preoperative immune-nutritional status has been shown to predict the postoperative prognosis in various types of cancer; however, the prognostic significance of the controlling nutritional status (CONUT) score in resected lung squamous cell carcinoma (SCC) has yet to be elucidated. A total of 108 patients with resected lung SCC were analyzed for their clinicopathological factors, including the CONUT score, which can be calculated from the serum albumin, total cholesterol, and total peripheral lymphocyte count. The patients were divided into two groups: CONUT low (0 or 1) or high (≥2). Among 108 patients, 76 (70.4%) were CONUT low, while 32 (29.6%) were CONUT high. No significant association between the CONUT score and the clinicopathological factors was found. Patients with CONUT high exhibited significantly shorter disease-free and overall survivals (DFS and OS) than those with CONUT low (P=0.016 and P=0.006, respectively). Multivariate analyses showed that the CONUT score [hazard ratio (HR): 1.902, 95% confidence interval (CI): 1.045-3.373, P=0.036], age (HR: 2.286, 95% CI: 1.246-4.304, P=0.007), pathological stage (HR: 2.527, 95% CI: 1.391-4.644, P=0.002), and lymphatic invasion (HR: 2.321, 95% CI: 1.110-4.493, P=0.027) were independent prognostic factors for the DFS. Furthermore, in a multivariate analysis, the CONUT score (HR: 1.909, 95% CI: 0.902-3.860, P=0.081), age (HR: 2.455, 95% CI: 1.208-5.178, P=0.013), pathological stage (HR: 2.488, 95% CI: 1.201-5.306, P=0.014), and lymphatic invasion (HR: 3.409, 95% CI: 1.532-7.240, P=0.004) were shown to be independent prognostic factors for the OS. The current study showed that the CONUT score was an independent prognostic factor for the DFS and OS in patients with resected lung SCC.

  17. Mutational status of EGFR and KIT in thymoma and thymic carcinoma.

    Science.gov (United States)

    Yoh, Kiyotaka; Nishiwaki, Yutaka; Ishii, Genichiro; Goto, Koichi; Kubota, Kaoru; Ohmatsu, Hironobu; Niho, Seiji; Nagai, Kanji; Saijo, Nagahiro

    2008-12-01

    This study was conducted to evaluate the prevalence of EGFR and KIT mutations in thymomas and thymic carcinomas as a means of exploring the potential for molecularly targeted therapy with tyrosine kinase inhibitors. Genomic DNA was isolated from 41 paraffin-embedded tumor samples obtained from 24 thymomas and 17 thymic carcinomas. EGFR exons 18, 19, and 21, and KIT exons 9, 11, 13, and 17, were analyzed for mutations by PCR and direct sequencing. Protein expression of EGFR and KIT was evaluated immunohistochemically. EGFR mutations were detected in 2 of 20 thymomas, but not in any of the thymic carcinomas. All of the EGFR mutations detected were missense mutations (L858R and G863D) in exon 21. EGFR protein was expressed in 71% of the thymomas and 53% of the thymic carcinomas. The mutational analysis of KIT revealed only a missense mutation (L576P) in exon 11 of one thymic carcinoma. KIT protein was expressed in 88% of the thymic carcinomas and 0% of the thymomas. The results of this study indicate that EGFR and KIT mutations in thymomas and thymic carcinomas are rare, but that many of the tumors express EGFR or KIT protein.

  18. Mucoepidermoid carcinoma of the posterior-lateral border of tongue: a rare presentation.

    Science.gov (United States)

    Mathew, Lisha; Janardhanan, Mahija; Suresh, Rakesh; Savithri, Vindhya

    2017-10-24

    Mucoepidermoid carcinoma (MEC) is the most common malignant tumour of the major and minor salivary glands. Minor salivary glands are scattered in different areas of the oral cavity such as palate, retromolar area, floor of the mouth, buccal mucosa, lips and tongue, but so far, only a few lingual MEC cases have been documented in the literature and most of the studies have shown a predilection for base and dorsum of the tongue. We report a rare case of MEC involving the posterior-lateral border of the tongue. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  19. Metastatic Renal Cell Carcinoma Presenting as Gastric Ulcer: Case Report and Literature Review

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    Alhareth Al Juboori

    2017-01-01

    Full Text Available Renal cell carcinoma (RCC accounts for approximately 3% of all adult malignancies. True gastrointestinal metastases, specifically to gastric wall, have been rarely observed. Herein we describe a case of delayed metastasis to gastric wall occurring more than a decade after previously curative nephrectomy for RCC. A 67-year-old male with history of right radical nephrectomy in 2001 for RCC was found to have an asymptomatic right lower lobe solitary lung mass upon routine follow-up in 2011, with final biopsy results showing metastatic RCC for which he was treated accordingly. In 2014, patient was evaluated for dyspepsia with microcytic anemia and underwent an esophagogastroduodenoscopy and colonoscopy. EGD revealed a solitary one-centimeter atypical ulcer in the posterior mid gastric body with biopsy results being consistent with metastatic RCC. Our literature review has yielded thirty-six reported cases of RCC in association with gastric wall metastases.

  20. Present status and prospects of radioisotopes and radiation utilization in Indonesia

    International Nuclear Information System (INIS)

    Baiquni, A.

    1982-01-01

    The present status and prospects of RI and radiation utilization in Indonesia, which developed under the Government's assistance and supervision since the opening of the research reactor in 1965, was reviewed. Utilization of short half-life RI in various fields was described. Utilization in medicine, sterilization of medical supplies, the industrial world and hydrology was detailed. Annual changes in these fields were shown and tables were presented. The status of various types of radiation and RI utilization in Indonesia, which included nuclear analytical techniques in industry and various laboratories in agriculture, industry and biology, was reported. Finally, the plan of construction of a third research reactor was referred to. (Chiba, N.)

  1. Quantitative real-time RT-PCR and chromogenic in situ hybridization: precise methods to detect HER-2 status in breast carcinoma

    Directory of Open Access Journals (Sweden)

    Soares Fernando A

    2009-03-01

    Full Text Available Abstract Background HER-2 gene testing has become an integral part of breast cancer patient diagnosis. The most commonly used assay in the clinical setting for evaluating HER-2 status is immunohistochemistry (IHC and fluorescence in situ hybridization (FISH. These procedures permit correlation between HER-2 expression and morphological features. However, FISH signals are labile and fade over time, making post-revision of the tumor difficult. CISH (chromogenic in situ hybridization is an alternative procedure, with certain advantages, although still limited as a diagnostic tool in breast carcinomas. Methods To elucidate the molecular profile of HER-2 status, mRNA and protein expression in 75 invasive breast carcinomas were analyzed by real time quantitative RT-PCR (qRT-PCR and IHC, respectively. Amplifications were evaluated in 43 of these cases by CISH and in 11 by FISH. Results The concordance rate between IHC and qRT-PCR results was 78.9%, and 94.6% for qRT-PCR and CISH. Intratumoral heterogeneity of HER-2 status was identified in three cases by CISH. The results of the three procedures were compared and showed a concordance rate of 83.8%; higher discordances were observed in 0 or 1+ immunostaining cases, which showed high-level amplification (15.4% and HER-2 transcript overexpression (20%. Moreover, 2+ immunostaining cases presented nonamplified status (50% by CISH and HER-2 downexpression (38.5% by qRT-PCR. In general, concordance occurred between qRT-PCR and CISH results. A high concordance was observed between CISH/qRT-PCR and FISH. Comparisons with clinicopathological data revealed a significant association between HER-2 downexpression and the involvement of less than four lymph nodes (P = 0.0350. Conclusion Based on these findings, qRT-PCR was more precise and reproducible than IHC. Furthermore, CISH was revealed as an alternative and useful procedure for investigating amplifications involving the HER-2 gene.

  2. Quantitative real-time RT-PCR and chromogenic in situ hybridization: precise methods to detect HER-2 status in breast carcinoma

    International Nuclear Information System (INIS)

    Rosa, Fabíola E; Silveira, Sara M; Silveira, Cássia GT; Bérgamo, Nádia A; Neto, Francisco A Moraes; Domingues, Maria AC; Soares, Fernando A; Caldeira, José RF; Rogatto, Silvia R

    2009-01-01

    HER-2 gene testing has become an integral part of breast cancer patient diagnosis. The most commonly used assay in the clinical setting for evaluating HER-2 status is immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). These procedures permit correlation between HER-2 expression and morphological features. However, FISH signals are labile and fade over time, making post-revision of the tumor difficult. CISH (chromogenic in situ hybridization) is an alternative procedure, with certain advantages, although still limited as a diagnostic tool in breast carcinomas. To elucidate the molecular profile of HER-2 status, mRNA and protein expression in 75 invasive breast carcinomas were analyzed by real time quantitative RT-PCR (qRT-PCR) and IHC, respectively. Amplifications were evaluated in 43 of these cases by CISH and in 11 by FISH. The concordance rate between IHC and qRT-PCR results was 78.9%, and 94.6% for qRT-PCR and CISH. Intratumoral heterogeneity of HER-2 status was identified in three cases by CISH. The results of the three procedures were compared and showed a concordance rate of 83.8%; higher discordances were observed in 0 or 1+ immunostaining cases, which showed high-level amplification (15.4%) and HER-2 transcript overexpression (20%). Moreover, 2+ immunostaining cases presented nonamplified status (50%) by CISH and HER-2 downexpression (38.5%) by qRT-PCR. In general, concordance occurred between qRT-PCR and CISH results. A high concordance was observed between CISH/qRT-PCR and FISH. Comparisons with clinicopathological data revealed a significant association between HER-2 downexpression and the involvement of less than four lymph nodes (P = 0.0350). Based on these findings, qRT-PCR was more precise and reproducible than IHC. Furthermore, CISH was revealed as an alternative and useful procedure for investigating amplifications involving the HER-2 gene

  3. Clinical presentation and visual status of retinitis pigmentosa patients: a multicenter study in southwestern Nigeria.

    Science.gov (United States)

    Onakpoya, Oluwatoyin Helen; Adeoti, Caroline Olufunlayo; Oluleye, Tunji Sunday; Ajayi, Iyiade Adeseye; Majengbasan, Timothy; Olorundare, Olayemi Kolawole

    2016-01-01

    To review the visual status and clinical presentation of patients with retinitis pigmentosa (RP). Multicenter, retrospective, and analytical review was conducted of the visual status and clinical characteristics of patients with RP at first presentation from January 2007 to December 2011. Main outcome measure was the World Health Organization's visual status classification in relation to sex and age at presentation. Data analysis by SPSS (version 15) and statistical significance was assumed at Ppresent in their siblings 15 (71.4%), grandparents 11 (52.3%), and parents 4 (19.4%). Forty (41.7%) were blind at presentation and 23 (24%) were visually impaired. Blindness in six (15%) patients was secondary to glaucoma. Retinal vascular narrowing and retinal pigmentary changes of varying severity were present in all patients. Thirty-five (36.5%) had maculopathy, 36 (37.5%) refractive error, 19 (20%) lenticular opacities, and eleven (11.5%) had glaucoma. RP was typical in 85 patients (88.5%). Older patients had higher rates of blindness at presentation (P=0.005); blindness and visual impairment rate at presentation were higher in males than females (P=0.029). Clinical presentation with advanced diseases, higher blindness rate in older patients, sex-related difference in blindness/visual impairment rates, as well as high glaucoma blindness in RP patients requires urgent attention in southwestern Nigeria.

  4. Pigmentation, Melanocyte Colonization, and p53 Status in Basal Cell Carcinoma

    International Nuclear Information System (INIS)

    Frey, L. M.; Houben, R.; Brocker, E. B.

    2011-01-01

    Basal cell carcinoma (BCC) is the most common neoplasm in the Caucasian population. Only a fraction of BCC exhibits pigmentation. Lack of melanocyte colonization has been suggested to be due to p53-inactivating mutations in the BCC cells interfering with the p53-proopiomelanocortin pathway and the production of alpha melanocyte-stimulating hormone in the tumor. To evaluate this, we determined tumor pigmentation as well as expression of melan-A and of p53 in 49 BCC tissues by means of immunohistochemistry. As expected, we observed a positive relation between tumor pigmentation and melan-A positive intra-tumoral melanocytes. Melanocyte colonization and, to a lesser extent, p53 overexpression showed intraindividual heterogeneity in larger tumors. p53 overexpression, which is indicative of p53 mutations, was not correlated to melanocyte colonization of BCC. Sequencing of exon 5-8 of the p53 gene in selected BCC cases revealed that colonization by melanocytes and BCC pigmentation is neither ablated by p53 mutations nor generally present in BCCs with wild-type p53.

  5. The Relationship Between Human Papillomavirus Status and Other Molecular Prognostic Markers in Head and Neck Squamous Cell Carcinomas

    International Nuclear Information System (INIS)

    Kong, Christina S.; Narasimhan, Balasubramanian; Cao Hongbin; Kwok, Shirley; Erickson, Julianna P.; Koong, Albert; Pourmand, Nader; Le, Quynh-Thu

    2009-01-01

    Purpose: To evaluate the relationship between human papillomavirus (HPV) status and known prognostic makers for head and neck cancers including tumor hypoxia, epidermal growth factor receptor (EGFR) expression and intratumoral T-cell levels and to determine the prognostic impact of these markers by HPV status. Methods and Materials: HPV status in 82 evaluable head and neck squamous cell carcinomas patients was determined by pyrosequencing and related to p16 INK4a staining and treatment outcomes. It was correlated with tumor hypoxia (tumor pO 2 and carbonic anhydrase [CAIX] staining), EGFR status, and intratumoral lymphocyte expression (CD3 staining). Results: Forty-four percent of evaluable tumors had strong HPV signal by pyrosequencing. There was a significant relationship between strong HPV signal and p16 INK4a staining as well as oropharynx location. The strong HPV signal group fared significantly better than others, both in time to progression (TTP, p = 0.008) and overall survival (OS, p = 0.004) for all patients and for the oropharyngeal subset. Positive p16 INK4a staining was associated with better TTP (p = 0.014) and OS (p = 0.00002). There was no relationship between HPV status and tumor pO 2 or CAIX staining. However, HPV status correlated inversely with EGFR reactivity (p = 0.0006) and directly with CD3(+) T-lymphocyte level (p = 0.03). Whereas CAIX and EGFR overexpression were negative prognostic factors regardless of HPV status, CD3(+) T-cell levels was prognostic only in HPV(-) tumors. Conclusion: HPV status was a prognostic factor for progression and survival. It correlated inversely with EGFR expression and directly with T-cell infiltration. The prognostic effect of CAIX and EGFR expression was not influenced by HPV status, whereas intratumoral T-cell levels was significant only for HPV(-) tumors.

  6. An overview of the present status of food irradiation and its prospect in Malaysia

    International Nuclear Information System (INIS)

    Muhammad bin Lebai Juri

    1984-01-01

    The paper seeks to review the present state of development in the food irradiation as a post harvest preservation technique. Brief discussion is focussed on the past and current status of the subject. The application of this method in Malaysia is explored due to its potential to be succesfully implemented. The prospect of its application is also highlighted. (author)

  7. Construction, characteristics and present status of high-fluence irradiation facility at University of Tokyo

    International Nuclear Information System (INIS)

    Tabata, Yoneho; Kobayashi, Hitoshi; Tagawa, Seiichi; Kouchi, Noriyuki.

    1989-01-01

    New ion accelerator facility (HIT Facility) was constructed at Research Center for Nuclear Science and Technology, University of Tokyo. This facility, which was equipped with some special apparatus, has been mainly dedicated to the study of radiation effects of ion beams on materials. In this report, the construction, the characteristics and the present status of this facility are described. (author)

  8. Overview of the present status and challenges of neutrino oscillation physics

    Energy Technology Data Exchange (ETDEWEB)

    Mocioiu, Irina [Pennsylvania State University, 104 Davey Lab, University Park, PA 16802 (United States)

    2012-11-20

    This is an overview of the current status of neutrino oscillation physics, including atmospheric, solar, reactor and accelerator neutrino experiments. After summarizing our present understanding of all data, I discuss the open questions and how they might be addressed in the future. I also discuss how neutrinos can be used to learn about new physics and astrophysics.

  9. Colliding beam experiments in the Siberian Institute for Nuclear Physics (Present status and prospects)

    International Nuclear Information System (INIS)

    Budker, G.I.

    1982-01-01

    Present status of construction of colliding (electron, positron, proton, antiproton and muon) beam facilities is described. Experiments conducted at the VEP-1 and VEPP-2 facilities in 1968-1970 are enumerated. The program of forthcoming investigations at the VAPP-NAP facility is described in brief

  10. Present status of practical aspects of individual dosimetry. Pt. 1. EC Member States

    International Nuclear Information System (INIS)

    Goeksu, H.Y.; Regulla, D.; Drexler, G.

    1995-01-01

    The study reviews the present status of radiation protection practices of occupationally exposed persons in the Member States of the European Communities by taking account of the new legislative changes. A special emphasis is given to identify and describe the difference in procedures and methods of personnel monitoring, dose assessment, record keeping and collective dose assessment in each country. (orig./HP)

  11. Investigation of neutrino properties in experiments at nuclear reactors: Present status and prospects

    International Nuclear Information System (INIS)

    Mikaelyan, L.A.

    2002-01-01

    The present status of experiments that are being performed at nuclear reactors in order to seek the neutrino masses, mixing, and magnetic moments, whose discovery would be a signal of the existence of physics beyond the Standard Model, is considered, along with their future prospects

  12. Present status of transport code development based on Monte Carlo method

    International Nuclear Information System (INIS)

    Nakagawa, Masayuki

    1985-01-01

    The present status of development in Monte Carlo code is briefly reviewed. The main items are the followings; Application fields, Methods used in Monte Carlo code (geometry spectification, nuclear data, estimator and variance reduction technique) and unfinished works, Typical Monte Carlo codes and Merits of continuous energy Monte Carlo code. (author)

  13. Unusual presentation of primary mandibular gingival squamous cell carcinoma in young male: A case report

    Directory of Open Access Journals (Sweden)

    Nishat Sultan

    2015-10-01

    Full Text Available BACKGROUND AND AIM: Squamous cell carcinoma (SCC is usually considered a disease of older people. Recently, there is a change in the occurrence of such lesions in young patients and lacking the established risk factors. CASE REPORT: A 21-year-old male reported with an innocuous gingival growth over lower incisors since a month. Within 15 days he noticed another gingival growth in same region lingually. The growths were mildly tender with no suppuration. The associated teeth were non-mobile and vital. The radiographic findings were insignificant. An excisional biopsy was performed under local anesthesia. The stained H and E section showed a hyper-parakeratinized stratified squamous surface epithelium with underlying connective tissue with collagen fibers, fibroblasts, blood vessels and areas of dense chronic inflammatory cell infiltrate. Epithelium exhibited features of dysplasia. There was a breach in the continuity of the basement membrane and the malignant epithelial cells were seen invading the connective tissue in form of thin cord. CONCLUSION: The histopathological study confirmed the diagnosis of well differentiated SCC. Oral SCC is not a disease of the elderly anymore. We also reviewed the literature of SCC in young patients. Thus biopsy is mandatory for any non-resolving gingival growth.

  14. Targeted Therapy of Hepatitis B Virus-Related Hepatocellular Carcinoma: Present and Future

    Directory of Open Access Journals (Sweden)

    Sarene Koh

    2016-02-01

    Full Text Available Cancer immunotherapy using a patient’s own T cells redirected to recognize and kill tumor cells has achieved promising results in metastatic melanoma and leukemia. This technique involves harnessing a patient’s T cells and then delivering a gene that encodes a new T cell receptor (TCR or a chimeric antigen receptor (CAR that allow the cells to recognize specific cancer antigens. The prospect of using engineered T cell therapy for persistent viral infections like hepatitis B virus (HBV and their associated malignancies is promising. We recently tested in a first-in-man clinical trial, the ability of HBV-specific TCR-redirected T cells to target HBsAg-productive hepatocellular carcinoma (HCC and demonstrated that these redirected T cells recognized HCC cells with HBV–DNA integration [1] We discuss here the possibility to use HBV-specific TCR-redirected T cells targeting hepatitis B viral antigens as a tumor specific antigen in patients with HBV-related HCC, and the potential challenges facing the development of this new immunotherapeutic strategy.

  15. Concurrent chemoradiotherapy for locally advanced lung carcinoma: present results and future prospects

    International Nuclear Information System (INIS)

    Reboul, F.; Vincent, P.; Brewer, Y.; Taulelle, M.

    1997-01-01

    The prognosis of locally advanced lung cancer is reportedly poor in all histologic types. In non-small cell lung cancer, radiation therapy alone results in disappointing long-term survival. Three recent randomized trials, however, have shown a limited but significant improvement of survival with induction chemotherapy, though local control remained poor in these studies as well as in small-cell lung cancer treated with chemotherapy and late radiotherapy. Tow randomized trials focusing on small-cell lung cancer have recently shown significant benefit due to the combination of early concurrent mediastinal irradiation and chemotherapy, with major improvement in local control and a more than 40% 2-year survival rate. The concept of concurrent chemoradiotherapy has also been studied in non-small cell carcinoma with several pilot studies leading to both encouraging results and improved survival rate (up to 40% at 2 years). Ongoing phase III trials are comparing sequential versus concurrent chemoradiotherapy and will define the role of radical surgery after chemoradiotherapy in locally advanced non-small cell lung cancer. (authors)

  16. The different radiation response and radiation-induced bystander effects in colorectal carcinoma cells differing in p53 status.

    Science.gov (United States)

    Widel, Maria; Lalik, Anna; Krzywon, Aleksandra; Poleszczuk, Jan; Fujarewicz, Krzysztof; Rzeszowska-Wolny, Joanna

    2015-08-01

    Radiation-induced bystander effect, appearing as different biological changes in cells that are not directly exposed to ionizing radiation but are under the influence of molecular signals secreted by irradiated neighbors, have recently attracted considerable interest due to their possible implication for radiotherapy. However, various cells present diverse radiosensitivity and bystander responses that depend, inter alia, on genetic status including TP53, the gene controlling the cell cycle, DNA repair and apoptosis. Here we compared the ionizing radiation and bystander responses of human colorectal carcinoma HCT116 cells with wild type or knockout TP53 using a transwell co-culture system. The viability of exposed to X-rays (0-8 Gy) and bystander cells of both lines showed a roughly comparable decline with increasing dose. The frequency of micronuclei was also comparable at lower doses but at higher increased considerably, especially in bystander TP53-/- cells. Moreover, the TP53-/- cells showed a significantly elevated frequency of apoptosis, while TP53+/+ counterparts expressed high level of senescence. The cross-matched experiments where irradiated cells of one line were co-cultured with non-irradiated cells of opposite line show that both cell lines were also able to induce bystander effects in their counterparts, however different endpoints revealed with different strength. Potential mediators of bystander effects, IL-6 and IL-8, were also generated differently in both lines. The knockout cells secreted IL-6 at lower doses whereas wild type cells only at higher doses. Secretion of IL-8 by TP53-/- control cells was many times lower than that by TP53+/+ but increased significantly after irradiation. Transcription of the NFκBIA was induced in irradiated TP53+/+ mainly, but in bystanders a higher level was observed in TP53-/- cells, suggesting that TP53 is required for induction of NFκB pathway after irradiation but another mechanism of activation must operate in

  17. Micronutrient status (calcium, zinc, vitamins D and E) in patients with medullary thyroid carcinoma: A cross-sectional study.

    Science.gov (United States)

    Emami, Ali; Nazem, Mohammad Reza; Shekarriz, Reza; Hedayati, Mehdi

    2017-09-01

    The aim of this study was to evaluate the micronutrient status of Iranian patients with medullary thyroid carcinoma (MTC) and to analyze potential relationships with respect to MTC risk. This was a cross-sectional study (Tehran Thyroid Cancer Survey 2015-2016). We measured and compared preoperative serum calcium, zinc, and vitamins D and E in patients with MTC and healthy controls. Forty cases with MTC and 40 (age-, sex-, and body mass index-matched) healthy controls voluntarily participated in the project. Serum calcium, zinc, and vitamin D and E concentrations were lower in the patients with cancer (P Ca calcium remarkably associated with enhanced risk for thyroid cancer (odds ratio [OR], 6.5; P = 0.001). Likewise, serum vitamin E was linked to the risk for cancer (OR, 1.31; P = 0.056). Moreover, serum zinc was correlated with vitamin E and calcium (r = +0.23; P = 0.04 and r = +0.25, P = 0.03; respectively). We also observed a correlation between calcium and vitamin E (r = +0.27; P = 0.02). A multiple-micronutrient decrease was confirmed in patients with MTC. A low serum calcium level was a potent risk factor for MTC. Findings from the present study suggest that dietary intake and/or supplementation of micronutrients, especially calcium and vitamin E, may be beneficial in reducing the risk for thyroid cancer. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Effect of integrated surgery + radiotherapy + chemotherapy treatment on survival status and serum indexes in patients with gallbladder carcinoma

    Directory of Open Access Journals (Sweden)

    Zhi-Li Wei

    2016-12-01

    Full Text Available Objective: To study the effect of integrated surgery + radiotherapy + chemotherapy treatment on the survival status and serum indexes in patients with gallbladder carcinoma. Methods: A total of 68 patients with gallbladder carcinoma were divided into observation group (received integrated surgery + radiotherapy + chemotherapy treatment and control group (received surgery + radiotherapy according to different treatments. Differences in the content of tumor markers, growth factors and adhesion molecules in serum as well as the median survival time and survival rate in 5 years of follow-up were compared between the two groups 1 month after treatment. Results: Tumor markers β2-MG, CA19-9, CA242, CA125, CA724, CEA and AFP content in serum of observation group after treatment were significantly lower than those of control group; growth factors VEGF, FGF, EGFR and HER2 content in serum were significantly lower than those of control group while IGFBP-2 and IGFBP-3 content were significantly higher than those of control group; adhesion molecules E-selectin, ICAM-1, VCAM-1 and sE-Cd content in serum were significantly lower than those of control group; the median survival time of 5-year follow-up as well as 1-, 3- and 5-year survival rate were significantly greater than those of control group. Conclusions: Integrated treatment of surgery + radiotherapy + chemotherapy can optimize the short-term and long-term curative effect in patients with gallbladder carcinoma.

  19. Present status of storage ring free electron laser experiment at ETL

    International Nuclear Information System (INIS)

    Yamazaki, T.; Nakamura, T.; Tomimasu, T.; Sugiyama, S.; Noguchi, T.

    1988-01-01

    Outline is described of the present status of the ETL storage-ring free electron laser project. The structure and the performance of the ETL-type transverse optical klystron are given. A modification of the dispersive section has decreased the degradation of the shape of the spontaneous-emission spectrum due to energy spread of the electron beam. Relevant parameters of the stored beam are presented. Measurement of the optical-cavity loss is under way. (author)

  20. Skeletal Muscle Metastasis as an Initial Presentation of Follicular Thyroid Carcinoma: A Case Report and a Review of the Literature

    Directory of Open Access Journals (Sweden)

    Mutahir A. Tunio

    2013-01-01

    Full Text Available Introduction. Follicular thyroid carcinoma (FTC frequently metastasizes to the lungs and bones. However, metastasis to the skeletal muscles is an extremely rare manifestation of FTC. To date, only seven cases of FTC have been reported in the literature. Skeletal muscle metastases from FTC usually remain asymptomatic or manifest as swelling and are associated with dismal prognosis. Case Presentation. A 45-year-old Saudi woman presented with right buttock swelling since 8 months. Physical examination revealed right gluteal mass of size  cm and right thyroid lobe nodule. The rest of examination was unremarkable. Magnetic resonance imaging (MRI showed  cm lobulated mass arising from the gluteus medius muscle, and tru-cut biopsy confirmed the metastatic papillary carcinoma of thyroid origin. The patient subsequently underwent palliative radiotherapy followed by total thyroidectomy and radioactive iodine ablation. At the time of publication, the patient was alive with partial response in gluteal mass. Conclusion. Skeletal muscles metastases are a rare manifestation of FTC, and searching for the primary focus in a patient with skeletal muscle metastasis, thyroid cancer should be considered as differential diagnosis.

  1. Present status and legal countermeasures of electromagnetic radiation pollution in China

    International Nuclear Information System (INIS)

    Qiu Qiu

    2007-01-01

    With the wide utilization of electronic technology, electromagnetic radiation has rapidly been one of the most serious pollution sources, causing corresponding disputes of pollution on the rise and the contradictions sharp increasingly because of the limited supply and research of law. The article analyses the characters and present status of electromagnetic radiation pollution, points out the inadequacy supply of relevant law and its reasons and presents legal countermeasures, that is: complying with present laws, establishing national standard systems, strengthening local legislation. The paper also presents the basic idea and principle of making 'Prevention Electromagnetic Radiation Pollution'. (authors)

  2. Refractory status epilepticus and glutamic acid decarboxylase antibodies in adults: presentation, treatment and outcomes.

    Science.gov (United States)

    Khawaja, Ayaz M; Vines, Brannon L; Miller, David W; Szaflarski, Jerzy P; Amara, Amy W

    2016-03-01

    Glutamic acid decarboxylase antibodies (GAD-Abs) have been implicated in refractory epilepsy. The association with refractory status epilepticus in adults has been rarely described. We discuss our experience in managing three adult patients who presented with refractory status epilepticus associated with GAD-Abs. Case series with retrospective chart and literature review. Three patients without pre-existing epilepsy who presented to our institution with generalized seizures between 2013 and 2014 were identified. Seizures proved refractory to first and second-line therapies and persisted beyond 24 hours. Patient 1 was a 22-year-old female who had elevated serum GAD-Ab titres at 0.49 mmol/l (normal: status epilepticus. Causation cannot be established since GAD-Abs may be elevated secondary to concurrent autoimmune diseases or formed de novo in response to GAD antigen exposure by neuronal injury. Based on this report and available literature, there may be a role for immuno- and chemotherapy in the management of refractory status epilepticus associated with GAD-Abs.

  3. Clinical presentation and outcome in patients treated for papillary and follicular carcinoma of the thyroid : patterns in Johannesburg

    International Nuclear Information System (INIS)

    Vangu, M.D.T.H.W.; Perumal, N.S.; Hersmen, G.; Botha, J.R.

    2004-01-01

    Full text: Purpose: To look at the clinical presentation and treatment outcome of patients with papillary thyroid carcinoma (PTC) and those with follicular thyroid carcinoma (FTC) in our institution. Methods: The records of all patients with papillary or follicular thyroid carcinoma seen at our institution were retrieved. Patients were excluded from this study if they underwent thyroid surgery outside a teaching hospital or presented to us more than 6 months post surgery, had deep external beam therapy (DXT) following surgery or a follow up of less than 3 years. This left clinical data and treatment outcomes of 140 patients available for a retrospective review. Results: One hundred and seventeen patients were females and 23 were males (5.1:1) with a median follow up of 10,5 years. The differences noted were as follow: there was a higher incidence of PTC than FTC (2.9:1); patients with PTC were younger at presentation (mean age 40 vs 49); more patients with PTC had metastases (60% vs 40%) and were much younger at presentation as compared to those with FTC (mean age 38 vs 63); at presentation eighty percent of FTC metastases were localized in bones whereas 60% of PTC metastases went to the lungs and 36% were confined to local lymph nodes. Similar pattern was found in those who developed metastases later. A significant percentage of ablation failure (41% vs 59% success rate) after the first high dose (2.96-3.7 GBq) of radioactive iodine (RAI) was noted. The total success rate increased to 80% after the second dose of RAI (3.7- 7.4 GBq). The majority of the patients ablated by the second dose had PTC and most had inadequate initial surgery ranging from unilateral lobectomy (10 patients), subtotal thyroidectomy (10 patients), and bilateral lobar resection (1 ). Conclusion: The predominance of PTC over FCT may indicate the conversion to an iodine repletion state in the country as a whole. Similar studies in other regions seem necessary to support this statement. The high

  4. Accuracy of sentinel lymph node biopsy for the assessment of auxiliary status in patients with early (T1) breast carcinoma

    International Nuclear Information System (INIS)

    Gurleyik, G.; Sekmen, U.; Saglam, A.; Aker, F.

    2005-01-01

    Objective: To determine the accuracy of SLN biopsy for the assessment of auxiliary status, and prognostic markers leading to lymphatic metastasis in patients with early (T1) breast cancer. Design: Cross-sectional study. Place and Duration of Study: Department of Surgery, Teaching and Research Hospital. Between January 2000 and August 2004. Patients and Methods: SLN mapping by blue dye method was performed on 39 patients with T1 breast carcinoma. SLNs, level 1 and 2 auxiliary nodes were dissected and excised. The size, pathologic features of the primary tumor, SLNs and other auxiliary nodes, and hormone receptors were evaluated by histopathologic examination. The rate of SLNs and non SLNs involvement, and demographic, clinical and pathologic risk factors leading to nodal metastasis were established. The diagnostic accuracy of SLN for auxiliary status was calculated. Results: SLNs were identified in 37 (95%) patients. The axilla had metastasis in 11 (28%) patients. Malignant cells involved SLNs in 8 patients. Non-SLNs had metastasis in 3 patients without SLN involvement. The sensitivity, specificity and accuracy of SLN biopsy for predicting auxiliary status was calculated as 73%, 100% and 92% respectively. Four of 5 patients T1c tumors (p=0.14) and lymphovascular invasion (p=0.0004). Conclusion: SLN biopsy with high diagnostic accuracy may prevent unnecessary disection of the axilla in the majority of patients with early (T1) breast carcinoma. Some risk factors as pre-menopausal status, absence of hormone receptors, and presence of lymphovascular invasion must be taken into account as important determinant of non-SLNs metastasis. (author)

  5. EMOTIONAL SELF-PRESENTATION ON WHATSAPP: ANALYSIS OF THE PROFILE STATUS

    Directory of Open Access Journals (Sweden)

    Кармен Маис-Аревало

    2018-12-01

    Full Text Available Self-presentation can be defined as “the process through which individuals communicate an image of themselves to others” (Yang and Brown, 2015: 404 and it is an essential part of human communication. Self-presentation has been widely studied both in face-to-face communication and online. Most online research, however, has focused on social networking sites, blogs, chatrooms, etc. while less attention has been paid to other online means of communication such as WhatsApp despite the growing im-portance of WhatsApp as a means of communication. The present paper aims to redress this imbalance by analysing self-presentation on WhatsApp; more specifically, by paying attention to emotional self-pre-sentation in profile status. To that purpose, a corpus of 206 WhatsApp statuses was gathered in Spanish. Results show the existence of recurrent patterns connected to variables such as sex1 or age, which play a crucial role in determining the emotions users choose to display in their profile status.

  6. The evolution of endometrial carcinoma classification through application of immunohistochemistry and molecular diagnostics: past, present and future.

    Science.gov (United States)

    Goebel, Emily A; Vidal, August; Matias-Guiu, Xavier; Blake Gilks, C

    2017-12-12

    Uterine cancer was first subclassified based on anatomic site, separating those tumours arising from the endometrium from cervical cancers. There was then further subclassification of endometrial cancers based on cell type, and this correlated with the Type I and Type II categories identified through the epidemiological studies of Bokhman, with endometrioid carcinoma corresponding (approximately) to Type I and serous carcinoma to Type II. These histotypes are not clearly separable in practice, however, with considerable interobserver variability in histotype diagnosis, especially for high-grade tumours. There followed studies of immunomarkers and then mutational studies of single genes, in attempts to improve subclassification. While these have revealed significant differences in protein expression and mutation profiles between endometrioid and serous carcinomas, there is also considerable overlap, so that there remain challenges in subclassification of endometrial carcinoma. Gene panel testing, using next-generation sequencing, was applied to endometrial cancers and highlighted that there are tumours that show genetic alterations intermediate between classic Type I/endometrioid and Type II/serous carcinomas. The Cancer Genome Atlas studies of endometrioid and serous carcinoma offered revolutionary insight into the subclassification of endometrial carcinoma, i.e. that there are four distinct categories of endometrial carcinoma, rather than two, based on genomic architecture. In this review, we provide an overview of immunohistochemical and molecular markers in endometrial carcinoma and comment on the important future directions in endometrial carcinoma subclassification arising from The Cancer Genome Atlas results.

  7. Distribution of Cervical Lymph Node Metastases From Squamous Cell Carcinoma of the Oropharynx in the Era of Risk Stratification Using Human Papillomavirus and Smoking Status.

    Science.gov (United States)

    Amsbaugh, Mark J; Yusuf, Mehran; Cash, Elizabeth; Silverman, Craig; Wilson, Elizabeth; Bumpous, Jeffrey; Potts, Kevin; Perez, Cesar; Bert, Robert; Redman, Rebecca; Dunlap, Neal

    2016-10-01

    To investigate the factors contributing to the clinical presentation of oropharyngeal squamous cell carcinoma (OPSCC) in the era of risk stratification using human papilloma virus (HPV) and smoking status. All patients with OPSCC presenting to our institutional multidisciplinary clinic from January 2009 to June 2015 were reviewed from a prospective database. The patients were grouped as being at low risk, intermediate risk, and high risk in the manner described by Ang et al. Variance in clinical presentation was examined using χ(2), Kruskal-Wallis, Mann-Whitney, and logistic regression analyses. The rates of HPV/p16 positivity (Phigh-risk patients presented with tumor stage T4 at a much higher than expected frequency (P=.003). Patients with BOT primary tumors who were never-smokers were less likely to have clinically involved ipsilateral neck disease than were former smokers (odds ratio 1.8; P=.038). The distribution of cervical lymph node metastases was not associated with HPV/p16 positivity, risk group, or subsite. When these data were compared with those in historical series, no significant differences were seen in the patterns of cervical lymph node metastases for patients with OPSCC. For patients with OPSCC differences in HPV status, smoking history and anatomic subsite were associated with differences in clinical presentation but not with distribution of cervical lymph node metastases. Historical series describing the patterns of cervical lymph node metastases in patients with OPSCC remain clinically relevant. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. De-novo simple partial status epilepticus presenting as Wernicke's aphasia.

    Science.gov (United States)

    Patil, Bhimanagouda; Oware, Agyepong

    2012-04-01

    Language disturbances manifesting as brief periods of speech arrest occur with seizures originating in the frontal or temporal lobes. These language disturbances are usually present with other features of seizures or may occur in an episodic fashion suggesting their likely epileptic origin. Sustained but reversible aphasia as the sole manifestation of partial status epilepticus is rare, particularly without a history of prior seizures. A few cases have been described in the literature where Broca's or mixed aphasia seems to be more common than Wernicke's aphasia. Here we describe a patient who presented with Wernicke's aphasia secondary to simple partial status epilepticus but without any other features of seizures. The diagnosis was confirmed on EEG and the aphasia reversed after antiepileptic treatment. Copyright © 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  9. Status of Her2 over expression in muscle invasive urothelial bladder carcinoma: Report of 21 cases

    Directory of Open Access Journals (Sweden)

    Nesrine Mejri

    2014-01-01

    Four patients died from disease, one of them had Her2 3+ score. Conclusion: Her2 overexpression can be observed in muscle invasive urothelial bladder carcinoma in an important number of patients. Evaluation criteria must be standardized, especially with heterogeneous cases. Metastases tests can also readdress the expression of Her2, which gives the patient a supplementary therapeutic tool.

  10. Present status of the NIRS-ECR ion source for the HIMAC

    International Nuclear Information System (INIS)

    Kitagawa, A.; Matsushita, H.; Shibuya, S.

    1995-01-01

    The present status of NIRS-ECR ion source for the Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences (NIRS) is reported. The beam intensity of the NIRS-ECR was increased by modifications on the magnetic field structure, chamber cooling system, vacuum conductance and the extraction configuration. The output current of Ar 6+ reached 365 eμA after improvements. The good stability, easy operation, and good reproducibility were realized. (author)

  11. Present status of radiation processing and its future development by using electron accelerator in Vietnam

    International Nuclear Information System (INIS)

    Tran Khac An; Tran Tich Canh; Doan Binh; Nguyen Quoc Hien

    2003-01-01

    In Vietnam, studies on Radiation Processing have been carried out since 1983. Some results are applicable in the field of agriculture, health and foodstuff, some researches were developed to commercial scale and others have high potential for development by using electron accelerator. The paper offers the present status of radiation processing and also give out the growing tendency of using electron accelerator in the future. (author)

  12. Present status and problems of remote systems technology in nuclear industry

    Energy Technology Data Exchange (ETDEWEB)

    1989-02-01

    This reports the activities of Special Committee on Remote Systems Technology, Atomic Energy Society of Japan, during the period from Oct. 1984 to Sep. 1988. The Committee studied and reviewed the present status and problems of remote operation and maintenance in various fields of nuclear industry. Reported items are; reactor operation, reprocessing, nuclear fusion and decommissioning. It also reviews robotics and remote systems tehcnology applied to space and marine development.

  13. Present status and problems of remote systems technology in nuclear industry

    International Nuclear Information System (INIS)

    1989-01-01

    This reports the activities of Special Committee on Remote Systems Technology, Atomic Energy Society of Japan, during the period from Oct. 1984 to Sep. 1988. The Committee studied and reviewed the present status and problems of remote operation and maintenance in various fields of nuclear industry. Reported items are; reactor operation, reprocessing, nuclear fusion and decommissioning. It also reviews robotics and remote systems tehcnology applied to space and marine development. (author)

  14. Present status of ESNIT (energy selective neutron irradiation test facility) program

    International Nuclear Information System (INIS)

    Noda, K.; Ohno, H.; Sugimoto, M.; Kato, Y.; Matsuo, H.; Watanabe, K.; Kikuchi, T.; Sawai, T.; Usui, T.; Oyama, Y.; Kondo, T.

    1994-01-01

    The present status of technical studies of a high energy neutron irradiation facility, ESNIT (energy selective neutron irradiation test facility), is summarized. Technological survey and feasibility studies of ESNIT have continued since 1988. The results of technical studies of the accelerator, the target and the experimental systems in ESNIT program were reviewed by an International Advisory Committee in February 1993. Recommendations for future R and D on ESNIT program are also summarized in this paper. ((orig.))

  15. Marital status and outcome of patients presenting with acute coronary syndrome: an observational report.

    Science.gov (United States)

    Hadi Khafaji, Hadi A R; Al Habib, Khalid; Asaad, Nidal; Singh, Rajvir; Hersi, Ahmad; Al Falaeh, Husam; Al Saif, Shukri; Al-Motarreb, Ahmed; Almahmeed, Wael; Sulaiman, Kadhim; Amin, Haitham; Al-Lawati, Jawad; Al-Sagheer, Norah Q; Alsheikh-Ali, Alawi A; Al Suwaidi, Jassim

    2012-12-01

    BACKGROUND & HYPOTHESIS: Data on the clinical characteristics and outcome of patients presenting with acute coronary syndrome (ACS) according to their marital status is not clear. A total of 5334 patients presenting with ACS in 65 hospitals in 6 Middle East countries in the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2) were studied according to their marital status (5024 married, 100 single, and 210 widowed patients). When compared to married patients, widowed patients were older and more likely to be female. Widowed patients were more likely to have diabetes mellitus, hypertension, history of heart failure, and peripheral vascular disease and were less likely to be tobacco users when compared to the other groups. Widowed patients were also more likely to present with atypical symptoms and have advanced Killip class. Widowed patients were more likely to present with non-ST-elevation myocardial infarction (NSTEMI) when compared to the other 2 groups. Widowed patients were more likely to have heart failure (P = 0.001), cardiogenic shock (P = 0.001), and major bleeding (P = 0.002) when compared to the other groups. No statistically significant difference was observed in regard to duration of hospital stay, door to needle time in STEMI patients, or cardiac arrhythmias between the various groups. Widowed patients had higher in-hospital, 30-day, and 1-year mortality rates (P = 0.001). Marital status was an independent predictor for in-hospital mortality. Widowed marital status was associated with worse cardiovascular risk profile, and worse in-hospital and 1-year outcome. Future work should be focused on whether the provision of psychosocial support will result in improved outcomes among this high-risk group. © 2012 Wiley Periodicals, Inc.

  16. Present status and future prospects for a Higgs boson discovery at the Tevatron and LHC

    International Nuclear Information System (INIS)

    Haber, Howard E

    2010-01-01

    Discovering the Higgs boson is one of the primary goals of both the Tevatron and the Large Hadron Collider (LHC). The present status of the Higgs search is reviewed and future prospects for discovery at the Tevatron and LHC are considered. This talk focuses primarily on the Higgs boson of the Standard Model and its minimal supersymmetric extension. Theoretical expectations for the Higgs boson and its phenomenological consequences are reviewed.

  17. Present status of radiation processing and its future development by using electron accelerator in Vietnam

    Energy Technology Data Exchange (ETDEWEB)

    Tran Khac An; Tran Tich Canh; Doan Binh [Research and Development Center for Radiation Technology (VINAGAMMA), Ho Chi Minh (Viet Nam); Nguyen Quoc Hien [Nuclear Research Institute (NRI), Dalat (Viet Nam)

    2003-02-01

    In Vietnam, studies on Radiation Processing have been carried out since 1983. Some results are applicable in the field of agriculture, health and foodstuff, some researches were developed to commercial scale and others have high potential for development by using electron accelerator. The paper offers the present status of radiation processing and also give out the growing tendency of using electron accelerator in the future. (author)

  18. Rare Presentation of Genitourinary Tuberculosis Masquerading as Renal Cell Carcinoma: A Histopathological Surprise

    Directory of Open Access Journals (Sweden)

    Santosh Kumar

    2014-01-01

    Full Text Available Genitourinary tuberculosis (GUTB is a rare extrapulmonary manifestation of tuberculosis (TB. Various forms of presentation are described and in most cases the disease results in calcification, atrophy, or necrosis of the renal parenchyma. The kidney is not generally palpable except in cases of hydronephrosis due to an upper ureteric stricture. We present a case of GUTB presenting as inflammatory pseudotumor. This case was initially diagnosed as renal malignancy and managed accordingly. Histopathology confirmed the diagnosis of pseudotumoral renal TB.

  19. Socioeconomic characteristics of patients with oropharyngeal carcinoma according to tumor HPV status, patient smoking status, and sexual behavior.

    Science.gov (United States)

    Dahlstrom, Kristina R; Bell, Diana; Hanby, Duncan; Li, Guojun; Wang, Li-E; Wei, Qingyi; Williams, Michelle D; Sturgis, Erich M

    2015-09-01

    Patients with oropharyngeal cancer (OPC) have distinct risk factor profiles reflected in the human papillomavirus (HPV) status of their tumor, and these profiles may also be influenced by factors related to socioeconomic status (SES). The goal of this study was to describe the socioeconomic characteristics of a large cohort of patients with OPC according to HPV status, smoking status, and sexual behavior. Patients with OPC prospectively provided information about their smoking and alcohol use, socioeconomic characteristics, and sexual behaviors. HPV status was determined by a composite of immunohistochemistry for p16 expression, HPV in situ hybridization, and PCR assay in 356 patients. Standard descriptive statistics and logistic regression were used to compare socioeconomic characteristics between patient subgroups. Patients with HPV-positive OPC had higher levels of education, income, and overall SES. Among patients with HPV-positive OPC, never/light smokers had more than 5 times the odds of having at least a bachelor's degree and being in the highest level of SES compared with smokers. Patients with HPV-positive OPC and those with higher levels of education and SES had higher numbers of lifetime any and oral sex partners, although not all of these differences were significant. Socioeconomic differences among subgroups of OPC patients have implications for OPC prevention efforts, including tobacco cessation, behavior modification, and vaccination programs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Present status of reactor physics in the United States and Japan-II. 6. Present Status of GNF New Nodal Simulator

    International Nuclear Information System (INIS)

    Iwamoto, T.; Tamitani, M.; Moore, B.

    2001-01-01

    This paper presents core simulator consolidation work done at Global Nuclear Fuel (GNF). The unified simulator needs to supersede the capabilities of past simulator packages from the original GNF partners: GE (Ref. 1), Hitachi (Ref. 2), and Toshiba (Ref. 3). At the same time, an effort is being made to produce a simulation package that will be a state-of-the-art analysis tool when released, in terms of the physics solution methodology and functionality. The core simulator will be capable and qualified for (a) high-energy cycles in the U.S. markets, (b) mixed-oxide (MOX) introduction in Japan, and (c) high-power density plants in Europe, etc. The unification of the lattice physics code is also in progress based on a transport model with collision probability methods. The AETNA core simulator is built upon the PANAC11 software base. The goal is to essentially replace the 1.5-energy group model with a higher-order multigroup nonlinear nodal solution capable of the required modeling fidelity, while keeping highly automated library generation as well as functionality. All required interfaces to PANAC11 will be preserved, which minimizes the impact on users and process automation. Preliminary results show statistical accuracy improvement over the 1.5- group model. The status of the GNF new nodal simulator is presented. It is built on a highly automated software base by combining the best technologies of GE, Hitachi, and Toshiba and will provide a BWR core analysis tool with high functionality and fidelity. (authors)

  1. Papillary Thyroid Carcinoma Metastases Presenting as Ipsilateral Adrenal Mass and Renal Cyst.

    Science.gov (United States)

    Ginzburg, Serge; Reddy, Madhu; Veloski, Colleen; Sigurdson, Elin; Ridge, John A; Azrilevich, Mikhail; Kutikov, Alexander

    2015-11-01

    Metastatic spread of differentiated thyroid cancer to genitourinary organs is rare. Synchronous presentation of renal and adrenal thyroid metastasis is even less common, this case being only the 3rd reported. We describe a case of a 60-year-old male with oligometastatic thyroid cancer, where adrenal and renal metastases were the only extracervical sites of disease and triggered the patient's presentation.

  2. Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy.

    Science.gov (United States)

    Schultz, Luciana; Albadine, Roula; Hicks, Jessica; Jadallah, Sana; DeMarzo, Angelo M; Chen, Ying-Bei; Nielsen, Matthew E; Neilsen, Matthew E; Gonzalgo, Mark L; Sidransky, David; Schoenberg, Mark; Netto, George J

    2010-12-01

    Bladder urothelial carcinoma has high rates of mortality and morbidity. Identifying novel molecular prognostic factors and targets of therapy is crucial. Mammalian target of rapamycin (mTOR) pathway plays a pivotal role in establishing cell shape, migration, and proliferation. Tissue microarrays were constructed from 132 cystectomies (1994-2002). Immunohistochemistry was performed for Pten, c-myc, p27, phosphorylated (phos)Akt, phosS6, and 4E-BP1. Markers were evaluated for pattern, percentage, and intensity of staining. Mean length of follow-up was 62.6 months (range, 1-182 months). Disease progression, overall survival (OS), and disease-specific survival (DSS) rates were 42%, 60%, and 68%, respectively. Pten showed loss of expression in 35% of bladder urothelial carcinoma. All markers showed lower expression in invasive bladder urothelial carcinoma compared with benign urothelium with the exception of 4E-BP1. Pten, p27, phosAkt, phosS6, and 4E-BP1 expression correlated with pathologic stage (pathological stage; P<.03). Pten, 4E-BP1, and phosAkt expression correlated with divergent aggressive histology and invasion. phosS6 expression inversely predicted OS (P=.01), DSS (P=.001), and progression (P=.05). c-myc expression inversely predicted progression (P=.01). In a multivariate analysis model that included TNM stage grouping, divergent aggressive histology, concomitant carcinoma in situ, phosS6, and c-myc expression, phosS6 was an independent predictor of DSS (P=.03; hazard ratio [HR], -0.19), whereas c-myc was an independent predictor of progression (P=.02; HR, -0.38). In a second model substituting organ-confined disease and lymph node status for TNM stage grouping, phosS6 and c-myc remained independent predictors of DSS (P=.03; HR, -0.21) and progression (P=.03; HR, -0.34), respectively. We found an overall down-regulation of mTOR pathway in bladder urothelial carcinoma. phosS6 independently predicted DSS, and c-myc independently predicted progression

  3. Use of quantitative diffusion-weighted magnetic resonance imaging to predict human papilloma virus status in patients with oropharyngeal squamous cell carcinoma.

    Science.gov (United States)

    Nakahira, Mitsuhiko; Saito, Naoko; Yamaguchi, Hiroshi; Kuba, Kiyomi; Sugasawa, Masashi

    2014-05-01

    Although identification of human papilloma virus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC) is essential in predicting treatment response, no imaging modality can currently determine whether a tumor is HPV-related. In this retrospective study, 26 patients with OPSCC confined to the lateral wall or the base of tongue underwent neck magnetic resonance imaging, using T1-, T2- and diffusion-weighted imaging (DWI). Apparent diffusion coefficients (ADCs) in a region of interest covering the largest available primary tumor area of OPSCC on a single slice of the ADC map were calculated using two b values (0 and 1,000 s/mm(2)). Mean and minimum ADCs were compared with HPV status, using p16 immunohistochemistry as a surrogate marker for HPV infection. Mean and minimum ADCs for HPV(+) OPSCC were significantly lower than those for HPV(-) OPSCC. A cut-off value of mean ADC for HPV(+) OPSCC of 1.027 × 10(-3) mm(2)/s yielded sensitivity and specificity of 83.33 and 78.57%, respectively. In conclusion, the present study indicates that ADC could be used to predict HPV status in patients with OPSCC.

  4. QUALITY ASSURANCE IN SECONDARY EDUCATION PROGRAME OF BANGLADESH OPEN UNIVERSITY: Present Status and Challenges

    Directory of Open Access Journals (Sweden)

    Zobaida AKHTER

    2008-04-01

    Full Text Available In the present day in national and international perspectives, quality is the top of most agendas. Quality of education has significant impact and invaluable contribution to the area of development. Recently, the SSC & HSC program of BOU have earned recognition of equivalency with the formal education sector, which has naturally raised the question of quality assurance of these programs By applying the quantitative method, the study has assessed the present status of the quality of SSC & HSC program of BOU and also put some recommendations to meet the challenges for further development.

  5. Present status and future perspective of research and test reactors in JAERI

    International Nuclear Information System (INIS)

    Baba, Osamu; Kaieda, Keisuke

    1999-01-01

    Since 1957, Japan Atomic Energy Research Institute (JAERI) has constructed several research and test reactors to fulfil a major role in the study of nuclear energy and fundamental research. At present, four reactors, the Japan Research Reactor No. 3 and No. 4 (JRR-3M and JRR-4 respectively), the Japan Materials Testing Reactor (JMTR) and the Nuclear Safety Research Reactor (NSRR), are in operation, and a new High Temperature Engineering Test Reactor (HTTR) has reached first criticality and is waiting for the power-up test. This paper introduce these reactors and describe their present operational status. The recent tendency of utilization and future perspectives are also reported. (author)

  6. Present status and future perspective of research and test reactors in JAERI

    Energy Technology Data Exchange (ETDEWEB)

    Baba, Osamu [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Kaieda, Keisuke

    1999-08-01

    Since 1957, Japan Atomic Energy Research Institute (JAERI) has constructed several research and test reactors to fulfil a major role in the study of nuclear energy and fundamental research. At present, four reactors, the Japan Research Reactor No. 3 and No. 4 (JRR-3M and JRR-4 respectively), the Japan Materials Testing Reactor (JMTR) and the Nuclear Safety Research Reactor (NSRR), are in operation, and a new High Temperature Engineering Test Reactor (HTTR) has reached first criticality and is waiting for the power-up test. This paper introduce these reactors and describe their present operational status. The recent tendency of utilization and future perspectives are also reported. (author)

  7. Fine needle aspiration biopsy of three cases of squamous cell carcinoma presenting as a thyroid mass: cytological findings and differential diagnosis.

    Science.gov (United States)

    Rosa, M; Toronczyk, K

    2012-02-01

    Primary squamous cell carcinomas of the thyroid gland are extremely rare, comprising about 1% of thyroid malignancies. Although squamous cell carcinomas are readily identified as such on aspiration cytology in the majority of cases, the differentiation of primary versus metastatic tumour might not always be easy. Herein, we report three cases of squamous cell carcinomas involving the thyroid gland. Fine needle aspiration cytology (FNAC) was performed in three patients with a thyroid mass using standard guidelines. Smears were stained with Diff-Quik and Papanicolaou stains. Two patients were male and one was female, aged 59, 45 and 35 years, respectively. In all three patients a thyroid mass was present. FNAC smears in all cases showed cytological features of squamous cell carcinoma including keratinization and necrosis. After clinical and cytological correlation, one case appeared to be primary, one case metastatic, and in the third case no additional clinical information or biopsy follow-up was available for further characterization. Because primary squamous cell carcinoma of the thyroid is a rare finding, metastatic squamous cell carcinoma should always be excluded first. Metastatic disease usually presents in the setting of widespread malignancy, therefore a dedicated clinical and radiological investigation is necessary in these cases. In both clinical scenarios the patient's prognosis is poor. © 2010 Blackwell Publishing Ltd.

  8. New Onset Refractory Status Epilepticus as an Unusual Presentation of a Suspected Organophosphate Poisoning

    Directory of Open Access Journals (Sweden)

    Shahan Waheed

    2014-01-01

    Full Text Available New onset refractory status epilepticus (NORSE is a new entity in medical literature. It has different infectious and noninfectious etiologies showing a devastating impact onto the clinical outcome of patients. Therapy with anaesthetic and antiepileptic agents often fails to improve the condition, unless the primary cause is rectified. Here is presented the case of a young female with a history of depression who after a recent bereavement came to the Emergency Department of Aga Khan University Hospital with complaints of drowsiness that lasted for few hours. Though she had no history of organophosphate poisoning, her physical examination and further investigations were suggestive of the diagnosis. During her hospital stay, she developed refractory status epilepticus. Her seizures did not respond to standard antiepileptic and intravenous anesthetic agents and subsided only after intravenous infusion of atropine for a few days. Organophosphate poisoning is a very common presentation in the developing world and the associated status epilepticus poses a devastating problem for emergency physicians. In patients with suspected organophosphate poisoning with favoring clinical exam findings, the continuation of atropine intravenous infusion can be a safe option to abate seizures.

  9. Papillary Thyroid Carcinoma Metastases Presenting as Ipsilateral Adrenal Mass and Renal Cyst

    Directory of Open Access Journals (Sweden)

    Serge Ginzburg

    2015-11-01

    Full Text Available Metastatic spread of differentiated thyroid cancer to genitourinary organs is rare. Synchronous presentation of renal and adrenal thyroid metastasis is even less common, this case being only the 3rd reported. We describe a case of a 60-year-old male with oligometastatic thyroid cancer, where adrenal and renal metastases were the only extracervical sites of disease and triggered the patient's presentation.

  10. The otological status of patients with nasopharyngeal carcinoma after megavoltage radiotherapy

    International Nuclear Information System (INIS)

    Tang, N.L.S.; Choy, A.T.K.; John, D.G.; Hassalt, C.A. van

    1992-01-01

    A middle ear effusion is a common complication of nasopharyngeal carcinoma both before and after radiotherapy. An effusion was found in 38 per cent of patients before radiotherapy and 9 per cent developed an effusion after the start of radiotherapy. Surgical treatment by myringotomy with or without grommet insertion was associated with a high incidence of otorrhoea (26 per cent) which was often refractory to treatment. In view of the frequency of this complication and the fact that a middle ear effusion may not be of concern to an adult patient with nasopharyngeal carcinoma, a wait and see policy may be appropriate in the management of a middle ear effusion in these patients. (Author)

  11. LaPlace's law revisited: Cecal perforation as an unusual presentation of pancreatic carcinoma

    Directory of Open Access Journals (Sweden)

    Cason Frederick D

    2007-02-01

    Full Text Available Abstract Background Pancreatic cancer is often locally and distally aggressive, but initial presentation as cecal perforation is uncommon. Case presentation We describe a patient presenting with pneumoperitoneum, found at initial exploration to have a cecal perforation believed to be secondary to a large cecal adenoma, after palpation of the remainder of the colon revealed hard stool but no distal obstruction. Postoperatively, however, the patient progressed to large bowel obstruction and upon reexploration, a mass could now be delineated, encompassing the splenic flexure, splenic hilum, and distal pancreas. Histological evaluation determined this was locally invasive pancreatic adenocarcinoma, and therefore the true etiology of the original cecal perforation. Conclusion Any perforation localized to the cecum must be highly suspicious for a distal obstruction, as dictated by the law of LaPlace.

  12. “An unusual presentation of colonic mucormycosis mimicking carcinoma colon- a surgeon’s perspective”

    Directory of Open Access Journals (Sweden)

    Prasanna Kumar Debata

    2015-01-01

    Conclusion: Knowing these unusual presentations of this disease, surgeon need to maintain a high index of suspicion and perform timely and appropriate diagnostic evaluation to improve patient outcome. Prompt diagnosis, reversal of predisposing conditions, and aggressive surgical debridement remain cornerstones of therapy for this deadly disease.

  13. Present status of unsealed radioisotope therapy in Japan based on the nation-wide questionnaire

    International Nuclear Information System (INIS)

    Oyamada, Hiyoshimaru

    1999-01-01

    In Japan, clinical application of unsealed radioisotopes is strictly regulated. Especially in the field of therapy, we are allowed to use only Na 131 I at present. Under such circumstances, the present status of therapeutic nuclear medicine in Japan was surveyed by means of a nation-wide questionnaire, conducted in 193 hospitals. Then, 113 hospitals replied to such questionnaire (recovery rate: 58.5%), and it was found that in 77 hospitals, radioisotope therapy is being performed for Graves' disease and/or thyroid cancer. The questionnaire covered the following points: for Graves' disease-the basic strategy of 131 I therapy, its indications, absorbed doses planned to be given, whether the therapy had been conducted on outpatient basis or in-patient basis, method of thyroid weight estimation, interval of administration in case of multiple doses, number of patients treated per year (1996) etc., and for thyroid cancer-strategy for thyroid remnant, the doses to be given, the maximum doses permitted by the authorities in each hospital both per day and per year, handling of highly contaminated urine in each hospital, interval of administration in case of multiple doses, number of patients treated per year (1996) etc. Also questioned were dissatisfaction with the present regulation by the authorities and/or requests for the better daily work, if any. Based on the above questionnaire, the present status of unsealed radioisotope therapy in Japan was investigated. (author)

  14. A multinodular goiter as the initial presentation of a renal cell carcinoma harbouring a novel VHL mutation

    Directory of Open Access Journals (Sweden)

    Silva Eduardo

    2006-10-01

    Full Text Available Abstract Background Secondary involvement of the thyroid gland is rare. Often the origin of the tumor is difficult to identify from the material obtained by fine-needle aspiration cytology. Renal cell carcinoma of the clear-cell type is one of the more common carcinomas to metastasize to the thyroid gland. Somatic mutations of the von Hippel-Lindau tumor suppressor gene are associated with the sporadic form of this tumor. We aimed to illustrate the potential utility of DNA based technologies to search for specific molecular markers in order to establish the anatomic site of origin. Case Presentation A 54-yr-old Caucasian male complaining of a rapidly increasing neck tumor was diagnosed as having a clear-cell tumor by fine-needle aspiration cytology. A positive staining for cytokeratin as well as for vimentin and CD10 in the absence of staining for thyroglobulin, calcitonin and TTF1 suggested a renal origin confirmed by computed tomography. Using frozen RNA, obtained from cells left inside the needle used for fine needle aspiration cytology, it was possible to identify a somatic mutation (680 delA in the VHL gene. Conclusion In the presence of a clear-cell tumor of the thyroid gland, screening for somatic mutations in the VHL gene in material derived from thyroid aspirates might provide additional information to immunocytochemical studies and therefore plays a contributory role to establish the final diagnosis. Moreover, in a near future, this piece of information might be useful to define a targeted therapy.

  15. An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study

    International Nuclear Information System (INIS)

    Abdul-Hussein, Amal; Morris, Pierre A; Markova, Tsveti

    2007-01-01

    Adenoid Cystic Carcinoma (ACC) is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence rate. Intracranial ACC is even more infrequent and could be primary or secondary occurring either by direct invasion, hematogenous spread, or perineural spread. We report the first case of the 5 th and 6 th nerve palsy due to cavernous sinus invasion by adenoid cystic carcinoma. A 49-year-old African American female presented to the emergency room complaining of severe right-sided headache, photophobia, dizziness and nausea, with diplopia. The patient had a 14 year history migraine headaches, hypertension, and mild intermittent asthma. Physical examination revealed right lateral rectus muscle palsy with esotropia. There was numbness in all three divisions of the right trigeminal nerve. Motor and sensory examination of extremities was normal. An MRI of the brain/brain stem was obtained which showed a large mass in the clivus extending to involve the nasopharynx, pterygoid plate, sphenoid and right cavernous sinuses. Biopsy showed an ACC tumor with a cribriform pattern of the minor salivary glands. The patient underwent total gross surgical resection and radiation therapy. This is a case of ACC of the minor salivary glands with intracranial invasion. The patient had long history of headaches which changed in character during the past year, and symptoms of acute 5 th and 6 th cranial nerve involvement. Our unique case demonstrates direct invasion of cavernous sinus and could explain the 5 th and 6 th cranial nerve involvement as histopathology revealed no perineural invasion

  16. Prognostic impact of body mass index stratified by smoking status in patients with esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Sun P

    2016-10-01

    Full Text Available Peng Sun,1,2,* Fei Zhang,1,2,* Cui Chen,3,* Chao Ren,1,2 Xi-Wen Bi,1,2 Hang Yang,1,2 Xin An,1,2 Feng-Hua Wang,1,2 Wen-Qi Jiang1,2 1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 2Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 3Department of Oncology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China *These authors contributed equally to this work Background: As smoking affects the body mass index (BMI and causes the risk of esophageal squamous cell carcinoma (ESCC, the prognostic impact of BMI in ESCC could be stratified by smoking status. We investigated the true prognostic effect of BMI and its potential modification by smoking status in ESCC. Methods: We retrospectively analyzed 459 patients who underwent curative treatment at a single institution between January 2007 and December 2010. BMI was calculated using the measured height and weight before surgery. Chi-square test was used to evaluate the relationships between smoking status and other clinicopathological variables. The Cox proportional hazard models were used for univariate and multivariate analyses of variables related to overall survival. Results: BMI <18.5 kg/m2 was a significantly independent predictor of poor survival in the overall population and never smokers after adjusting for covariates, but not in ever smokers. Among never smokers, underweight patients (BMI <18.5 kg/m2 had a 2.218 times greater risk of mortality than non-underweight (BMI =18.5 kg/m2 patients (P=0.015. Among ever smokers, BMI <18 kg/m2 increased the risk of mortality to 1.656 (P=0.019, compared to those having BMI =18 kg/m2. Conclusion: Our study is likely the first to show that the prognostic effect of BMI was substantial in ESCC, even after stratifying by smoking status. Furthermore, the risk of death due to low BMI would be significantly increased in never smokers. We believe that

  17. Clinical presentation and visual status of retinitis pigmentosa patients: a multicenter study in southwestern Nigeria

    Directory of Open Access Journals (Sweden)

    Onakpoya OH

    2016-08-01

    Full Text Available Oluwatoyin Helen Onakpoya,1 Caroline Olufunlayo Adeoti,2 Tunji Sunday Oluleye,3 Iyiade Adeseye Ajayi,4 Timothy Majengbasan,4,5 Olayemi Kolawole Olorundare1 1Department of Ophthalmology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, 2Department of Ophthalmology, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, 3Department of Ophthalmology, University College Hospital, Ibadan, 4Department of Ophthalmology, University Teaching Hospital, Ado-Ekiti, 5Department of Ophthalmology, Federal Medical Centre, Ido-Ekiti, Nigeria Background: To review the visual status and clinical presentation of patients with retinitis pigmentosa (RP.Methodology: Multicenter, retrospective, and analytical review was conducted of the visual status and clinical characteristics of patients with RP at first presentation from January 2007 to December 2011. Main outcome measure was the World Health Organization’s visual status classification in relation to sex and age at presentation. Data analysis by SPSS (version 15 and statistical significance was assumed at P<0.05.Results: One hundred and ninety-two eyes of 96 patients with mean age of 39.08±18.5 years and mode of 25 years constituted the study population; 55 (57.3% were males and 41 (42.7% females. Loss of vision 67 (69.8% and night blindness 56 (58.3% were the leading symptoms. Twenty-one (21.9% patients had a positive family history, with RP present in their siblings 15 (71.4%, grandparents 11 (52.3%, and parents 4 (19.4%. Forty (41.7% were blind at presentation and 23 (24% were visually impaired. Blindness in six (15% patients was secondary to glaucoma. Retinal vascular narrowing and retinal pigmentary changes of varying severity were present in all patients. Thirty-five (36.5% had maculopathy, 36 (37.5% refractive error, 19 (20% lenticular opacities, and eleven (11.5% had glaucoma. RP was typical in 85 patients (88.5%. Older patients had higher rates of blindness at presentation (P=0

  18. The different radiation response and radiation-induced bystander effects in colorectal carcinoma cells differing in p53 status

    Energy Technology Data Exchange (ETDEWEB)

    Widel, Maria, E-mail: maria.widel@polsl.pl [Biosystems Group, Institute of Automatic Control, Silesian University of Technology, 16 Akademicka Street, 44-100 Gliwice (Poland); Lalik, Anna; Krzywon, Aleksandra [Biosystems Group, Institute of Automatic Control, Silesian University of Technology, 16 Akademicka Street, 44-100 Gliwice (Poland); Poleszczuk, Jan [College of Inter-faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, 93 Zwirki i Wigury Street, 02-089 Warsaw (Poland); Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida (United States); Fujarewicz, Krzysztof; Rzeszowska-Wolny, Joanna [Biosystems Group, Institute of Automatic Control, Silesian University of Technology, 16 Akademicka Street, 44-100 Gliwice (Poland)

    2015-08-15

    Highlights: • We tested radiation response and bystander effect on HCT116p53+/+ and p53−/− cells. • The p53+/+ cells developed premature senescence in exposed and bystander neighbors. • Directly exposed and bystander p53−/− cells died profoundly through apoptosis. • Interleukins 6 and 8 were differently generated by both cell lines. • NFκB path was activated mainly in p53+/+ hit cells, in p53 −/− in bystanders only. - Abstract: Radiation-induced bystander effect, appearing as different biological changes in cells that are not directly exposed to ionizing radiation but are under the influence of molecular signals secreted by irradiated neighbors, have recently attracted considerable interest due to their possible implication for radiotherapy. However, various cells present diverse radiosensitivity and bystander responses that depend, inter alia, on genetic status including TP53, the gene controlling the cell cycle, DNA repair and apoptosis. Here we compared the ionizing radiation and bystander responses of human colorectal carcinoma HCT116 cells with wild type or knockout TP53 using a transwell co-culture system. The viability of exposed to X-rays (0–8 Gy) and bystander cells of both lines showed a roughly comparable decline with increasing dose. The frequency of micronuclei was also comparable at lower doses but at higher increased considerably, especially in bystander TP53-/- cells. Moreover, the TP53-/- cells showed a significantly elevated frequency of apoptosis, while TP53+/+ counterparts expressed high level of senescence. The cross-matched experiments where irradiated cells of one line were co-cultured with non-irradiated cells of opposite line show that both cell lines were also able to induce bystander effects in their counterparts, however different endpoints revealed with different strength. Potential mediators of bystander effects, IL-6 and IL-8, were also generated differently in both lines. The knockout cells secreted IL-6 at

  19. The different radiation response and radiation-induced bystander effects in colorectal carcinoma cells differing in p53 status

    International Nuclear Information System (INIS)

    Widel, Maria; Lalik, Anna; Krzywon, Aleksandra; Poleszczuk, Jan; Fujarewicz, Krzysztof; Rzeszowska-Wolny, Joanna

    2015-01-01

    Highlights: • We tested radiation response and bystander effect on HCT116p53+/+ and p53−/− cells. • The p53+/+ cells developed premature senescence in exposed and bystander neighbors. • Directly exposed and bystander p53−/− cells died profoundly through apoptosis. • Interleukins 6 and 8 were differently generated by both cell lines. • NFκB path was activated mainly in p53+/+ hit cells, in p53 −/− in bystanders only. - Abstract: Radiation-induced bystander effect, appearing as different biological changes in cells that are not directly exposed to ionizing radiation but are under the influence of molecular signals secreted by irradiated neighbors, have recently attracted considerable interest due to their possible implication for radiotherapy. However, various cells present diverse radiosensitivity and bystander responses that depend, inter alia, on genetic status including TP53, the gene controlling the cell cycle, DNA repair and apoptosis. Here we compared the ionizing radiation and bystander responses of human colorectal carcinoma HCT116 cells with wild type or knockout TP53 using a transwell co-culture system. The viability of exposed to X-rays (0–8 Gy) and bystander cells of both lines showed a roughly comparable decline with increasing dose. The frequency of micronuclei was also comparable at lower doses but at higher increased considerably, especially in bystander TP53-/- cells. Moreover, the TP53-/- cells showed a significantly elevated frequency of apoptosis, while TP53+/+ counterparts expressed high level of senescence. The cross-matched experiments where irradiated cells of one line were co-cultured with non-irradiated cells of opposite line show that both cell lines were also able to induce bystander effects in their counterparts, however different endpoints revealed with different strength. Potential mediators of bystander effects, IL-6 and IL-8, were also generated differently in both lines. The knockout cells secreted IL-6 at

  20. The influence of circumferential resection margin status on loco-regional recurrence in esophageal squamous cell carcinoma.

    Science.gov (United States)

    Park, Hae Jin; Kim, Hak Jae; Chie, Eui Kyu; Kang, Chang Hyun; Kim, Young Tae

    2013-06-01

    To analyze treatment outcomes and patterns of recurrence, and to examine the impact of adjuvant postoperative radiotherapy (PORT) after esophagectomy in esophageal squamous cell carcinoma (SqCC) regarding the status of circumferential resection margin (CRM). We performed a retrospective review of esophageal cancer patients operated in Seoul National University Hospital between 2003 and 2010. Pathologically proven T3 SqCC patients with written reports mentioning the status of CRM were selected. Fifty-nine out of 71 patients (83.1%) had CRM+. Twenty-eight patients had radiotherapy in CRM+ and CRM-, respectively. The median follow-up period was 17.1 months (range: 5.2-63.1). Median survival and 2-year overall survival were 13.8 months and 41.9% in CRM+, and 27.3 months and 74.1% in CRM-, respectively. Loco-regional relapse-free survival (LRRFS) rate at 2 years was 33.6% and 74.1% in each groups (P = 0.029). Loco-regional recurrence was the major pattern of failure in CRM+. PORT did not improve LRRFS. The esophageal SqCC patients with CRM+ after resection showed worse LRRFS. This finding validated the prognostic value of CRM status. Nevertheless, we failed to demonstrate the benefits of adjuvant PORT in CRM+. This might suggest the necessity of neoadjuvant therapy to decrease the CRM+ rate after esophagectomy. Copyright © 2012 Wiley Periodicals, Inc.

  1. Present status and future plan of the research using HIMAC of NIRS

    International Nuclear Information System (INIS)

    Kawachi, Kiyomitsu

    1996-01-01

    The Heavy Ion Medical Accelerator in Chiba (HIMAC) was completed in 1993, and since June of 1994 heavy ion therapy has made a new start at this facility after closed-down of the BEVALAC accelerator at LBL in Berkeley, California in 1992. The HIMAC is also opened for the researchers of outside of NIRS as well as the clinical trial of the heavy ion therapy. In this report, I will describe on the present status of HIMAC facility, the beam characteristics and the future developments of HIMAC. (author)

  2. Present status of NMCC and sample preparation method for bio-samples

    International Nuclear Information System (INIS)

    Futatsugawa, S.; Hatakeyama, S.; Saitou, S.; Sera, K.

    1993-01-01

    In NMCC(Nishina Memorial Cyclotron Center) we are doing researches on PET of nuclear medicine (Positron Emission Computed Tomography) and PIXE analysis (Particle Induced X-ray Emission) using a small cyclotron of compactly designed. The NMCC facilities have been opened to researchers of other institutions since April 1993. The present status of NMCC is described. Bio-samples (medical samples, plants, animals and environmental samples) have mainly been analyzed by PIXE in NMCC. Small amounts of bio-samples for PIXE are decomposed quickly and easily in a sealed PTFE (polytetrafluoroethylene) vessel with a microwave oven. This sample preparation method of bio-samples also is described. (author)

  3. Present status of brachytherapy using Co-RALS in the national hospital and sanatorium in Japan

    International Nuclear Information System (INIS)

    Uno, Takashi; Itami, Jun; Abe, Yoshihisa; Dokiya, Takushi; Yorozu, Atsunori; Nishio, Masamichi; Hata, Yoshihiro; Ogita, Mikio

    1998-01-01

    The present status of brachytherapy using Co-RALS machine in the national hospital and sanatorium were investigated, by a questionnaire method. Questionnaire concerned about the equipment, machine trouble, patient population, together with the stuff of each department. Most of the Co-RALS machines were introduced between 1982 and 1987. Quality of Co-RALS treatment is questionable in several hospitals which lacks radiation therapy personnel. Number of patients treated per year are too small to sustain the cost of Ir-HDR treatment. It is concluded that introduction of Ir-HDR machine should be considered for small number of hospitals where patients population and personnel scale are sufficient. (author)

  4. Present status of spallation target development. JAERI/KEK Joint Project

    International Nuclear Information System (INIS)

    Hino, R.; Kaminaga, M.; Haga, K.

    2001-01-01

    The Japan Atomic Energy Research Institute (JAERI) and the High Energy Accelerator Research Organization (KEK) are promoting a plan to construct a neutron scattering facility under the JAERI/KEK Joint Project. Design and R and D works are being carried out vigorously for realizing the mercury target system consisting of the mercury target, moderators and reflectors working as a spallation neutron source, as well as a remote handling system for exchanging such components which will be highly irradiated. This report introduces an outline of the present status of design and development activities on the spallation target system. (author)

  5. Present status of an integrated software system for HASP (Human Acts Simulation Program)

    International Nuclear Information System (INIS)

    Otani, Takayuki; Ebihara, Ken-ichi; Kambayashi, Shaw; Kume, Etsuo; Higuchi, Kenji; Fujii, Minoru; Akimoto, Masayuki

    1994-01-01

    In Human Acts Simulation Program (HASP), human acts to be realized by a human-shaped intelligent robot in a nuclear power plant are simulated by computers. The major purpose of HASP is to develop basic and underlying design technologies for intelligent and automatic power plant. The objectives of this paper is to show the present status of the HASP, with particular emphasis on activities targetted at the integration of developed subsystems to simulate the important capabilities of the intelligent robot such as planning, robot dynamics, and so on. (author)

  6. SigmaCalc recent development and present status of the evaluated cross-sections for IBA

    Energy Technology Data Exchange (ETDEWEB)

    Gurbich, A.F.

    2016-03-15

    A new version of the SigmaCalc Internet site ( (http://sigmacalc.iate.obninsk.ru)) intended to provide evaluated differential cross-sections for spectra simulation is presented. Results of the revision of previously evaluated cross-sections and new evaluations including data for PIGE were made available to the IBA community through a simple interface. New SigmaCalc features allow users to compare evaluated differential cross-sections with the available results of the cross-section measurements taken on-the-fly from the IBANDL database and to validate them against benchmarks. The current status of the evaluated cross-sections for IBA is discussed.

  7. AMS using 14UD Pelletron at TIFR, Mumbai: present status and future prospects

    International Nuclear Information System (INIS)

    Surendran, P.; Gupta, A.K.; Nair, J.P.; Mahata, K.; Shrivastava, A.; Yadav, M.L.; Sparrow, H.; Thomas, R.G.; Bhagwat, P.V.; Kailas, S.; Kale, R.M.

    2011-01-01

    The AMS (Accelerator Mass Spectrometry) is a versatile tool employed in multidisciplinary programmes. The AMS programme at the BARC-TIFR 14UD Pelletron accelerator has been initiated with major emphasis on the determination of 36 Cl concentration in environment in general and water samples in particular. Preliminary measurements related to detection of 129 I have been carried out in recent past. The system used for AMS measurement is based on a 14 MV Tandem Accelerator. In this paper, the status and future prospects of AMS programme at BARC-TIFR Pelletron Accelerator Facility are presented

  8. Overview on collision processes of highly charged ions with atoms present status and problems

    International Nuclear Information System (INIS)

    Janev, R.K.

    1983-05-01

    This paper provides a brief discussion on the present status of the collision physics of highly charged ions with atoms. The emphasis is on the main achievements in understanding and describing the most important collision processes, and as charge transfer, ionization and Auger-type processes, and even more on those open problems which, due either to their scientific or practical importance, represent challenges to current research in this field. The paper concentrates on general ideas and problems whose development and solutions have advanced or will advance our basic understanding of the collision dynamics of multiply charged ions with atoms

  9. The present status of medical physics education and training in Europe: an EFOMP survey

    DEFF Research Database (Denmark)

    Eudaldo, T.; Olsen, K.

    2008-01-01

    The aim of this work is to present the results of an EFOMP's survey on the status of Education and Training of Medical Physics in Europe. This survey has been undertaken by EFOMP in 2005, to update the document "Policy Statement No. 1", which represents the starting point of the EFOMP recommendat......The aim of this work is to present the results of an EFOMP's survey on the status of Education and Training of Medical Physics in Europe. This survey has been undertaken by EFOMP in 2005, to update the document "Policy Statement No. 1", which represents the starting point of the EFOMP...... recommendations on Education and Training in Medical Physics. Ultimate results have been collected at the end of 2006. To perform the survey, a questionnaire was sent to 34 National Member Organisations (NMOs) for Medical Physics, to collect information on the present state of education and training in each...... European country. Twenty-five countries participated in the enquiry and responded to it. The most outstanding results are as follows: In all countries, the basic requirement to enter the Medical Physics education is a university degree. The length of this university education ranges from 2 to 5 years...

  10. Present status of doctors' awareness for radiation-induced carotid artery disease in Japan

    International Nuclear Information System (INIS)

    Taguchi, Yoshiharu; Takashima, Shutaro; Tanaka, Kortaro

    2013-01-01

    Radiation-induced carotid artery disease (RCAD) often develops in patients who have received neck radiotherapy for the treatment of various malignant tumors. However, the doctors who ordered or performed neck radiotherapy seem to pay little attention to RCAD which may subsequently occur, and the present status of the awareness in these doctors for RCAD is unclear in Japan. Therefore, we conducted a questionnaire survey of the present status of these doctors' awareness for RCAD. A questionnaire form regarding the recognition of RCAD was sent to 368 departments of otolaryngology, oral surgery, or radiology of university hospitals in Japan. Responses to the questionnaire were received from 213 of the 368 departments of otolaryngology, oral surgery or radiology of university hospitals (response collection rate: 57.9%). One hundred and sixty-one departments (75.9%) were aware of the existence of RCAD, but only 20 departments (9.4%) conducted regular examinations for RCAD after neck radiotherapy such as ultrasound neck echography and MR angiography. Only 6.3% departments took preventive measures for RCAD such as reduction in radiation dose or administration of antiplatelets. The present survey revealed that many patients who had undergone neck radiotherapy for the treatment of malignancy did not receive proper medical attention for RCAD in Japan. Healthcare providers should be given adequate education about RCAD including its risk factors, possible preventive measures, diagnostic modalities, and treatment. Furthermore, a systematic clinical network should be established in which stroke specialists conduct proper examinations for early diagnosis of RCAD. (author)

  11. Medical image of the week: urothelial carcinoma with pulmonary metastases presenting with shoulder pain

    Directory of Open Access Journals (Sweden)

    Jarrett B

    2017-06-01

    Full Text Available No abstract available. Article truncated after 150 words. A 68 year old man with a past medical history significant only for mild hyperlipidemia and distant cigar smoking presented to this primary physician’s office with a chief complaint of left sided shoulder pain for more than 6 months duration. His only other complaint was a hacking morning cough that was attributed to GERD after resolution with omperazole therapy. He was without any other complaints such as weight loss, fevers, chills, night sweats, shortness of breath, or dyspnea on exertion. His physical exam was without any abnormality. An initial radiograph of the rileft shoudler was obtained which was without any obvious bony abnormality but demonstrated numerous potential pulmonary nodules (Figure 1. He was then referred to pulmonology for further assessment. A chest CT scan peformed with contrast again demonstrated numerous pulmonary nodules with thick walled central cavitations throughout the lung parenchyma bilaterally (Figures 2 & 3. Additional testing performed included …

  12. [The hidradenocarcinoma of the wrist - an extremely rare malignant carcinoma: case presentation and literature review].

    Science.gov (United States)

    Arsalan-Werner, A; Mentzel, T; Kempf, B; Sauerbier, M

    2013-10-01

    Hidradenocarcinomas are rare, yet highly malignant tumors of eccrine sweat gland origin. Due to its locally aggressive growth and likelihood for metastasis it should be considered as a differential diagnosis especially in case of suspicious intraoperative findings. We report the case of a 73-year-old female patient presenting with a hidradenocarcinoma of the wrist. Treatment of hidradenocarcinomas is similar to the treatment of sarcomas: The first step is an incisional biopsy and obtaining an expert second opinion on the histopathological diagnosis as well as staging. The second step is a clear margin resection of the tumor and the plastic-surgical reconstruction. A long-term follow-up is mandatory to detect potential recurrence or metastasis. © Georg Thieme Verlag KG Stuttgart · New York.

  13. A Case Of Primary Central Nervous System Vasculitis Who Presented With Status Epilepticus

    Directory of Open Access Journals (Sweden)

    Sırma Geyik

    2014-12-01

    Full Text Available Primary central nervous system vasculitis (PCNV is limited with central nervous system and rare vasculitis that mostly seen in middle-aged men. PCNV vasculitis is usually presented that headache, dementia, stroke and multifocal common neurological symptoms. PCNV especially involves small medium-sized leptomeningeal and cortical arteries. 43 years old male patient who have been progressive forgetfulness and headache for 3 years. He applied with recurrent that before starting right focal and than sprawling whole body which generalized tonic-clonic seizures to us. During management that he was transfered to the intensive care unit due to status epilepticus (SE. Later than we found right hemiparesis, motor aphasia and right babinski positivity in neurologic examination. Diffusion restriction was revealed in left MCA territory in diffusion magnetic resonance imaging(MRI. EEG showed two types abnormality that a slow background ritm and epileptiform activity. Biochemistry of blood, complete blood count, blood sedimentation rate, CRP and markers of vasculitis were found in the normal range. Cerebral anjiography revealed that irregularities in the distal vascular areas and fusiform aneurysm at the top of basilar artery. He was consulted with rheumatology and diagnosed central nervous system vasculitis with the existing findings. Biopsy couldn't be taken from the brain to verify the diagnosis. Finally, we applied treatment that pulse steroid and cyclophosphamide to patient. This case has been presented due to emphasize that PCNV rarely may play a role in the etiology of recurrent stroke and status epilepticus.

  14. Present status and future development of the European Community rapid information system

    International Nuclear Information System (INIS)

    Fraser, G.

    1990-01-01

    Following the Chernobyl reactor accident it was rapidly appreciated that, in addition to upgrading national radiological monitoring systems, action was required to facilitate international communication of the results obtained. The first such system was established by the Vienna Convention, drawn up under the auspices of the IAEA, which came into force in September, 1986. Subsequently the EC Council of Ministers decided in December, 1987, to set up a Community system which in many ways parallels that established by the Convention but differs significantly in certain aspects concerning its legal basis, initiation criteria, data provisions and communications requirements. The present paper describes the present status of the Community system and foreseeable future developments. It is a matter of policy that, to avoid unnecessary complications, this system should be, to the maximum extent practicable, fully compatible with that established by the Convention. Where appropriate, therefore, reference is also made to the latter system

  15. Thermal hydraulic codes for LWR safety analysis - present status and future perspective

    Energy Technology Data Exchange (ETDEWEB)

    Staedtke, H. [Commission of the European Union, Ispra (Italy)

    1997-07-01

    The aim of the present paper is to give a review on the current status and future perspective of present best-estimate Thermal Hydraulic codes. Reference is made to internationally well-established codes which have reached a certain state of maturity. The first part of the paper deals with the common basic code features with respect to the physical modelling and their numerical methods used to describe complex two-phase flow and heat transfer processes. The general predictive capabilities are summarized identifying some remaining code deficiencies and their underlying limitations. The second part discusses various areas including physical modelling, numerical techniques and informatic structure where the codes could be substantially improved.

  16. Electricity in Europe. Present status and prospects for the 1990s

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, A

    1986-01-01

    Europe's electricity industry is entering a period of extreme uncertainty. This report sets out the reasons for this and tabulates the current electricity capacity in Europe. Chapter 2 considers the Electricity trade in Europe. Chapter 3 concentrates on nuclear power. In this, nuclear energy consumption in 1974 -1984, estimates of total and nuclear electricity generation to 2000, the European nuclear reactor types and the performance of reactors are tabulated. Nuclear power stations under construction are listed. A forecast is made of European nuclear capacity to 2000. The status of nuclear power in 1986 in Europe is summarized country by country. The future of nuclear power in Europe, following the Chernobyl reactor accident is considered, taking the situation in each country separately. Chapter 4 considers Electricity and the Environment, Chapter 5 looks at the prices of electricity in Europe, Chapter 6 is a country by country profile which presents the present and predicted electricity power situation in that country.

  17. Thermal hydraulic codes for LWR safety analysis - present status and future perspective

    International Nuclear Information System (INIS)

    Staedtke, H.

    1997-01-01

    The aim of the present paper is to give a review on the current status and future perspective of present best-estimate Thermal Hydraulic codes. Reference is made to internationally well-established codes which have reached a certain state of maturity. The first part of the paper deals with the common basic code features with respect to the physical modelling and their numerical methods used to describe complex two-phase flow and heat transfer processes. The general predictive capabilities are summarized identifying some remaining code deficiencies and their underlying limitations. The second part discusses various areas including physical modelling, numerical techniques and informatic structure where the codes could be substantially improved

  18. Present status and future perspectives of research and test reactor in Japan

    International Nuclear Information System (INIS)

    Kaneko, Yoshihiko; Kaieda, Keisuke

    2000-01-01

    Since 1957, Japan Atomic Energy Research Institute (JAERI) has constructed several research and test reactors to fulfill a major role in the study of nuclear energy and fundamental research. At present four reactors, the Japan Research Reactor No. 3 and No. 4 (JRR-3M and JRR-4 respectively), the Japan Materials Testing Reactor (JMTR) and the Nuclear Safety Research Reactor (NSRR) are in operation, and a new High Temperature Engineering Test Reactor (HTTR) has recently reached first criticality and now in the power up test. In 1966, the Kyoto University built the Kyoto University Reactor (KUR) and started its operation for joint use program of the Japanese universities. This paper introduces these reactors and describes their present operational status and also efforts for aging management. The recent tendency of utilization and future perspectives is also reported. (author)

  19. Present status and future perspectives of research and test reactor in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Kaneko, Yoshihiko [Atomic Energy Research Laboratory, Musashi Institute of Technology, Kawasaki, Kanagawa (Japan); Kaieda, Keisuke [Department of Research Reactor, Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan)

    2000-10-01

    Since 1957, Japan Atomic Energy Research Institute (JAERI) has constructed several research and test reactors to fulfill a major role in the study of nuclear energy and fundamental research. At present four reactors, the Japan Research Reactor No. 3 and No. 4 (JRR-3M and JRR-4 respectively), the Japan Materials Testing Reactor (JMTR) and the Nuclear Safety Research Reactor (NSRR) are in operation, and a new High Temperature Engineering Test Reactor (HTTR) has recently reached first criticality and now in the power up test. In 1966, the Kyoto University built the Kyoto University Reactor (KUR) and started its operation for joint use program of the Japanese universities. This paper introduces these reactors and describes their present operational status and also efforts for aging management. The recent tendency of utilization and future perspectives is also reported. (author)

  20. Electricity in Europe. Present status and prospects for the 1990s

    International Nuclear Information System (INIS)

    Holmes, Andrew.

    1986-01-01

    Europe's electricity industry is entering a period of extreme uncertainty. This report sets out the reasons for this and tabulates the current electricity capacity in Europe. Chapter 2 considers the Electricity trade in Europe. Chapter 3 concentrates on nuclear power. In this, nuclear energy consumption in 1974 -1984, estimates of total and nuclear electricity generation to 2000, the European nuclear reactor types and the performance of reactors are tabulated. Nuclear power stations under construction are listed. A forecast is made of European nuclear capacity to 2000. The status of nuclear power in 1986 in Europe is summarized country by country. The future of nuclear power in Europe, following the Chernobyl reactor accident is considered, taking the situation in each country separately. Chapter 4 considers Electricity and the Environment, Chapter 5 looks at the prices of electricity in Europe, Chapter 6 is a country by country profile which presents the present and predicted electricity power situation in that country. (UK)