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Sample records for carcinoma medular del

  1. Estudio del protooncogen Ret en neoplasia endocrina multiple 2A y en carcinoma medular en tiroides familiar: Hallazgos clínico-patológicos en portadores asintomáticos Analysis of the RET protooncogene in multiple endocrine neoplasia 2A and in familial medullary thyroid carcinoma: Clinical-pathological findings in asymptomatic carriers

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    Belli, S; M.E. Storani; R. J. Dourisboure; Podesta, E J; A. R. Solano

    2003-01-01

    El 25% de los carcinomas medulares de tiroides son hereditarios. Se presentan en forma de familiar (CMTF 5%) o como neoplasia endocrina múltiple (MEN) tipo 2A (17%) o 2B (3%), y comparten la herencia, autosómica dominante, de una mutación germinal en el protooncogen RET en uno de 12 codones conocidos. Estudiamos 7 familias (5 CMTF y 2 MEN 2A) con el objeto de detectar la mutación familiar e identificar a los portadores asintomáticos. Seis de las siete mutaciones (4 CMTF y 2 MEN 2A) fueron en ...

  2. Estudio del protooncogen Ret en neoplasia endocrina multiple 2A y en carcinoma medular en tiroides familiar: Hallazgos clínico-patológicos en portadores asintomáticos Analysis of the RET protooncogene in multiple endocrine neoplasia 2A and in familial medullary thyroid carcinoma: Clinical-pathological findings in asymptomatic carriers

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    S. Belli

    2003-01-01

    Full Text Available El 25% de los carcinomas medulares de tiroides son hereditarios. Se presentan en forma de familiar (CMTF 5% o como neoplasia endocrina múltiple (MEN tipo 2A (17% o 2B (3%, y comparten la herencia, autosómica dominante, de una mutación germinal en el protooncogen RET en uno de 12 codones conocidos. Estudiamos 7 familias (5 CMTF y 2 MEN 2A con el objeto de detectar la mutación familiar e identificar a los portadores asintomáticos. Seis de las siete mutaciones (4 CMTF y 2 MEN 2A fueron en el codón más frecuente, el 634, y una familia con CMTF presentó una mutación germinal novel: una transición T>C en el codón 630, resultando el cambio C630A. De los 57 individuos estudiados, 25 (43.85 % fueron portadores de la mutación, 7 de éstos (28% eran portadores asintomáticos de los cuales 5 eran niños, con una edad X-=11±3.2 años y fueron tiroidectomizados. Presentaron hiperplasia de células C y focos de microcarcinoma en ambos lóbulos tiroideos aun cuando la calcitonina basal o estimulada con pentagastrina fueron normales. En conclusión, describimos una mutación germinal novel en el protooncogen RET: C630A y el hallazgo de enfermedad de la célula C en los portadores asintomáticos, que enfatiza la importancia de la tiroidectomía profiláctica tan pronto como se confirma el diagnóstico molecular.Twenty five percent of the medullary thyroid carcinoma (MTC is hereditary and 5% is familiar (FMTC, or considered as multiple endocrine neoplasia (MEN type 2A (17% or 2B (3%. These diseases are the result of the autosomic dominant inheritance of a mutation in the RET protooncogene, in one out of 12 different known codons. We analyzed 7 families (2 MEN 2A and 5 FMTC. Six mutations were detected in the most frequent codon, 634 (2 MEN 2A y 4 FMTC and one family with FMTC presented a novel mutation: a transition T>C at codon 630, resulting a C630A change. Among 57 individuals studied, 25 (43.85% presented the mutation. Seven (28% were asymptomatic

  3. Estudio neuropsicológico del deterioro cognitivo ligero en la lesión medular espinal

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    Molina Gallego, Brígida

    2016-01-01

    Esta investigación ha tenido como objetivo evaluar la función cognitiva en los pacientes lesionados medulares espinales, teniendo en cuenta el tiempo de evolución desde su lesión. Para ello se investigó la existencia de diferencias en cuanto al rendimiento cognitivo se refiere, en pacientes con lesión medular aguda en relación con los pacientes con lesión medular crónica. La muestra estuvo formada por 100 pacientes que habían sufrido una lesión medular, concretamente la evaluación se real...

  4. Estudio inmunohistoquímico de P 53 en carcinomas poco diferenciados del tiroides

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    Vázquez Ramírez, Francisco José

    1998-01-01

    El interés por la patología tumoral tiroidea permanece a pesar de los muchos conocimientos adquiridos, al existir numerosas incógnitas no sólo en la patogénesis de las lesiones, sino en su propia valoración diagnóstica. La oncogénesis tiroidea humana, tan ampliamente investigada, ha llevado al estudio de diversos oncogenes. Así, se conoce la intervención de protooncogén RET en el desarrollo del carcinoma medular (mutaciones) y en el carcinoma pailar (reordenamiento y mutaciones: RET/PTC). ...

  5. Influencia de la movilización rítmica del nervio mediano en la funcionalidad del miembro superior en un paciente con lesión medular: Estudio de un caso

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    Bustillo Solórzano, Cristina

    2014-01-01

    RESUMEN: Introducción: La lesión medular es una enfermedad neurológica frecuente que produce secuelas que limitan la independencia funcional y deterioran la calidad de vida de las personas afectadas. La movilización neural trata de restablecer el equilibrio dinámico entre el movimiento de los tejidos neuronales y las conexiones mecánicas de los alrededores, promoviendo así la función fisiológica óptima, restaurándose la mecánica y el estado fisiológico normal del movimiento y de ...

  6. La mejora de la calidad de vida de las personas con lesión medular: La transición del centro rehabilitador a la vida cotidiana desde la perspectiva de los usuarios

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    Mariona Gifre Monreal

    2010-07-01

    Full Text Available El proceso de retorno a la vida cotidiana para una persona con lesión medular después de su periodo de hospitalización, se ha definido como un momento lleno de dificultades, ambigüedades y retos personales.En este trabajo nos planteamos identificar los factores más relevantes que contribuyen a mejorar su calidad de vida, desde la perspectiva de las propias personas afectada. Para ello, hemos realizado dos grupos de discusión: uno formado por 12 personas con paraplejia y otro formado por 6 personas con tetraplejia. El análisis de contenido realizado con las transcripciones de los dos grupos indica que, para los participantes existen dos dimensiones relacionadas con el nivel de calidad de vida una vez salen del centro de rehabilitación: a necesidad de atención al entorno más próximo y b preparación para el mundo real. Como conclusión señalamos la necesidad de incluir la atención integral a las personas con lesión medular desde los diferentes niveles asistenciales del territorio. 

  7. Tratamiento del SDRC en niños mediante estimulación eléctrica medular

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    M. J. Rodríguez-López; M. Fernández-Baena; C. Aldaya

    2013-01-01

    Introducción: El SDRC lo define la IASP como "un cuadro de dolor desproporcionado a la causa que lo produce, acompañado de alteraciones sensoriales tales como alodinia/hiperalgesia, disfunción autonómica y motora que ocurre después de un trauma que, con frecuencia, es trivial y que se presenta, por lo general, en una extremidad". Estos síntomas están bien descritos en los adultos, pero existen pocos datos sobre la prevalencia en la población pediátrica. A diferencia del adulto, el 90 % de los...

  8. Carcinoma epidermoide del conducto auditivo externo

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    Javier Alfonso Rodríguez

    2009-02-01

    Full Text Available Acude a la consulta de Otorrinolaringología un paciente masculino de 43 años de procedencia urbana que comienza con una otorrea de larga evolución (aproximadamente dos años, para la que llevó numerosos tratamientos para la otitis externa que presentaba, con estos antecedentes y lo constatado al examen se decide realizar toma de muestra (biopsia de la zona, diagnosticándose un Carcinoma Epidermoide, del conducto auditivo externo, patología poco frecuente en nuestro medio.A 43 years-old, urban, male patient assists the consultation of Otolaryngology with a long evolving otorrea (around two years, receiving several treatments against the external otitis he suffered. With those antecedents and what we found when examining him, we decided to take a sample (biopsy of the area, diagnosing an epidermoid carcinoma of the left external canal, an infrequent pathology in our settings.

  9. Traumatismos medulares em canídeos

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    Jorge, Salomé Mariana Candeias

    2009-01-01

    Os traumatismos medulares representam uma parte importante da casuística de um hospital veterinário. As causas destes traumatismos podem ser intrínsecas e extrínsecas. A principal causa intrínseca é a extrusão do material do disco intervertebral (Hérnia discal tipo I de Hansen). As principais causas extrínsecas são fracturas, luxações e subluxações vertebrais secundárias a eventos traumáticos. As lesões de origem vascular (tromboembolismo de uma artéria medular terminal ou embo...

  10. Esophageal carcinoma extending into the spinal canal - case report and review of the literature; Carcinoma do esofago com invasao do canal medular - relato de caso e revisao da literatura

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    Urban, Linei A.B.D.; Rogacheski, Enio; Ledesma, Jorge A. [Parana Univ., Curitiba, PR (Brazil). Hospital de Clinicas. Servico de Radiologia]. E-mail: radiohc@terra.com.br; Zaparolli, Mauricio; Duarte, Maria Cecilia B. [Parana Univ., Curitiba, PR (Brazil). Hospital de Clinicas; Sakamoto, Danielle G. [Parana Univ., Curitiba, PR (Brazil). Hospital de Clinicas. Servico de Anatomia Patologica

    2002-06-01

    The authors report the case of a 62-year-old male with a 4 month history of weight loss and a 2 day complaint of weakness and paraesthesia on the lower limbs. A computed tomography myelogram revealed a mass in the posterior mediastinum associated with destruction of the vertebral body, spinal canal extension and irregular esophageal wall thickening. The patient was later submitted to a barium esophagogram that showed an irregular filling defect. A biopsy confirmed the presence of a squamous cell carcinoma. This is the first report in the Latin-American literature (Lilacs) of a patient with an esophageal carcinoma with spinal canal extension and spinal cord compression syndrome at initial presentation. (author)

  11. Compresión medular dorsal extradural por condroma

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    B. B. Srota

    1950-03-01

    Full Text Available For the first time in Argentine bibliography a chondroma of the vertebra with extradural dorsal medular compression, is described. The clinical characteristics of the onset by intermitent medular claudication of Dejerine and the painless evolution until surgical intervention, are stressed. The bibliography is put up to date and the radiographics signs and the pathologic anatomy of the chondromas, are studied.

  12. Granuloma esquistossomotico medular: registro de um caso

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    Lamartine Corrêa de Moraes Junior

    1984-09-01

    Full Text Available Os autores relatam um caso de granuloma esquistossomótico de localização medular cujo diagnóstico inicial, foi de tumor intramedular sem caracterização nosológica. O resultado e diagnóstico, após exame histológico da peça cirúrgica, bem como aspectos diagnósticos através de exames complementares e características endêmicas do processo são discutidos.

  13. Fisioterapia Respiratoria en pacientes con Tetraplejia por Lesión Medular

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    Jiménez de la Torre, Beatriz

    2015-01-01

    La tetraplejia, resultado de una lesión medular, presenta una prevalencia de 5-40 casos por millón/año. Aunque en España, la prevalencia ha disminuido gracias a las medidas preventivas, es una de las patologías que más afecta a la calidad de vida de los pacientes; teniendo como referencia el Hospital Nacional de Parapléjicos de Toledo, por lo que hace que este proceso merezca una especial atención dentro del ámbito de la fisioterapia. El objetivo del presente trabajo es realizar una exposi...

  14. Quality of life improvement in people with spinal cord injury: The transition from rehabilitation hospital to the everyday life from users’ perspective La mejora de la calidad de vida de las personas con lesión medular: La transición del centro rehabilitador a la vida cotidiana desde la perspectiva de los usuarios

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    Mariona Gifre Monreal

    2010-07-01

    Full Text Available Returning process to the everyday life context for a person with spinal cord injury after its Hospitalization period has been defined as a moment of difficulties and personal challenges. 
    In this article we show the most prominent factors contributing to improve quality of life from the perspective of the injured people. Two discussion groups, one formed by 12 people with paraplegia, and another formed by 6 people with tetraplejia, have been carried out. Content analysis carried out indicates that participants related quality of life quality once leaving the rehabilitation hospital with to dimensions: a closer context need of attention and, b real world preparation. On conclusion, to design integral rehabilitation programme, physical rehabilitation, learning abilities to allow maximum autonomy and, family assessment must be included. 

    El proceso de retorno a la vida cotidiana para una persona con lesión medular después de su periodo de hospitalización, se ha definido como un momento lleno de dificultades, ambigüedades y retos personales.

    En este trabajo nos planteamos identificar los factores más relevantes que contribuyen a mejorar su calidad de vida, desde la perspectiva de las propias personas afectada. Para ello, hemos realizado dos grupos de discusión: uno formado por 12 personas con paraplejia y otro formado por 6 personas con tetraplejia. El análisis de contenido realizado con las transcripciones de los dos grupos indica que, para los participantes existen dos dimensiones relacionadas con el nivel de calidad de vida una vez salen del centro de rehabilitación: a necesidad de atención al entorno más próximo y b preparación para el mundo real. Como conclusión señalamos la necesidad de incluir la atención integral a las personas con lesión medular desde los diferentes niveles asistenciales del territorio.

     

  15. Paracoccidioidomicose evidenciando comprometimento medular tratada com sucesso por fluconazol

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    Leandro Pajuaba de Moura

    1994-03-01

    Full Text Available O envolvimento do sistema nervoso central na paracoccidioidomicose tem sido raramente descrito na literatura e sua frequência varia de 9,99% a 27,27%, manifestando-se basicamente sob duas formas clínicas: meníngea e pseudotumoral (abscessos, granulomas, nódulos ou cistos. O Paracoccidioides brasiliensis incide principalmente nos hemisférios cerebrais, podendo acometer ainda cerebelo, ponte, bulbo, meninges cerebrais e raquidianas, sendo excepcional o comprometimento do parênquima medular. Os autores apresentam o caso de um paciente com paracoccidioidomicose com evidências clínicas de comprometimento medular, comprovada por exames complementares indiretos pouco invasivos. Destacam a resposta terapêutica inédita a novo agente antifúngico bistriazólico, o fluconazol, pela primeira vez utilizado nesta forma de apresentação clínica da doença. Salientam a rariedade do comprometimento medular, o diagnóstico através de propedêutica não cirúrgica e a excelente resposta a este novo tratamento.

  16. Cushing syndrome secondary to a medullary thyroid carcinoma: report of a case and review of the literature = Síndrome de Cushing secundario a carcinoma medular de tiroides: descripción de un caso y revisión de la literatura

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    Gutiérrez Restrepo, Johnayro

    2014-08-01

    Full Text Available We report the case of a 29-year old female who was evaluated because of a thyroid tumor. The initial pathological classification was an insular thyroid carcinoma. There was strong involvement in the neck, mediastinum and lungs. Three years after receiving specific therapy for her thyroid neoplasia, she developed a Cushing syndrome and liver lesions suggestive of metastases from the primary tumor. A review of the previous pathological material revealed a medullary thyroid carcinoma producing ACTH, instead of the insular carcinoma. Based on this case a review of the literature is presented.

  17. Alteraciones del control mitosis-diferenciación en el carcinoma de piel

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    Alonso Lecue, Pilar

    2015-01-01

    RESUMEN: El cáncer de piel no melanocítico es el tipo de cáncer más común en sus dos formas predominantes: carcinoma Basocelular (BCC) y carcinoma escamoso (SCC). De manera paradójica, los SCCs muestran una morfología más típica de la diferenciación escamosa, y sin embargo, son más invasivos y metastatizan con mayor frecuencia que los BCCs. Con el objetivo de dilucidar la causa del diferente grado de malignidad de los dos tipos de carcinomas, hemos estudiado las alteraciones en el control de...

  18. Cushing syndrome secondary to a medullary thyroid carcinoma: report of a case and review of the literature = Síndrome de Cushing secundario a carcinoma medular de tiroides: descripción de un caso y revisión de la literatura

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    Gutiérrez Restrepo, Johnayro; Castro Martínez, Diva Cristina; Vélez Hoyos, Alejandro; Pérez Cadavid, Juan Camilo

    2014-01-01

    We report the case of a 29-year old female who was evaluated because of a thyroid tumor. The initial pathological classification was an insular thyroid carcinoma. There was strong involvement in the neck, mediastinum and lungs. Three years after receiving specific therapy for her thyroid neoplasia, she developed a Cushing syndrome and liver lesions suggestive of metastases from the primary tumor. A review of the previous pathological material revealed a medullary thyroid carcinoma producing A...

  19. Estudio clínico retrospectivo del uso de un sistema de hidrocirugía en pacientes lesionados medulares con úlceras por presión crónicas Retrospective clinical study of an hydrogurgery system on spinal cord injured patients with chronic pressure ulcers

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    J.M. Arévalo Velasco

    2011-03-01

    Full Text Available Realizamos un estudio clínico retrospectivo con pacientes lesionados medulares crónicos en el Hospital Nacional de Parapléjicos (Toledo, España, intervenidos quirúrgicamente por una o varias úlceras por presión de carácter crónico durante el año 2008. Revisamos 84 historias clínicas de pacientes a los cuales se realizaron 141 procedimientos quirúrgicos. Sólo en 8 casos se realizó una cirugía puramente de limpieza (bisturí más hidrocirugía sin realizar consecutivamente el tratamiento de cobertura de la lesión. Los restantes 133 procedimientos de limpieza más cobertura inmediata se distribuyeron en 2 grupos según el tipo de desbridamiento realizado: grupo I (n = 71, sólo desbridamiento quirúrgico con bisturí y grupo II (n = 62 desbridamiento con bisturí más uso posterior de un sistema de hidrocirugía de flujo continuo a alta presión. Según la localización, las lesiones ulcerosas tratadas fueron: isquiáticas 69 (48,94 %, sacras 49 (34,75 %, trocantéreas 15 (10,63 % y otras (talones y maléolos 8 (5,67%. Como conclusiones, establecemos que más del 54 % de los procedimientos llevados a cabo (72 de 133 curaron en la primera intervención y no necesitaron más cirugías; un 38% (51 de 133 fueron intervenciones realizadas en pacientes con úlceras muy evolucionadas y/o de difícil solución; la tasa de recidivas al año fue del 4,4 %; no encontramos diferencias significativas en cuanto a la tasa de curación entre los grupos I y II (p We carried out a retrospective study on spinal cord injured patients from the National Hospital for Paraplegics (Toledo, Spain, who were surgically treated during 2008 to alleviate the problems elicited by one or more pressure ulcers of chronic nature. We reviewed the clinical histories of 84 patients that received 141 surgical procedures, 8 were of radical nature (scalpel plus hidrosurgery without wound covering. The remaining 133 procedures of surgical cleaning and immediate wound

  20. Control de márgenes quirúrgicos del carcinoma basocelular según la especialidad del cirujano

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    Bassas Freixas, Patricia

    2012-01-01

    Introducción: el principal tratamiento del carcinoma basocelular (CBC) es la extirpación quirúrgica. Objetivo: determinar la prevalencia de márgenes afectados por el tumor, globalmente y en función del especialista que lo interviene. Métodos: se realizó un estudio retrospectivo de de los informes histológicos de CBC (enero de 2009 - marzo de 2010), un análisis estadístico (Chi-cuadrado de Pearson, U de Mann-Whitney, test de Kruskal-Wallis) y multivariable mediante regresión

  1. Entrenamiento de la marcha en el lesionado medular. Uso de sistemas electromecánicos y estimulación transcraneal no invasiva

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    Benito Penalva, Jesús

    2013-01-01

    Las lesiones medulares presentan, como una de las consecuencias principales, una alteración o pérdida de la capacidad de marcha. Basado en modelos animales, a finales de los años 80 se desarrolló el Entrenamiento de la Marcha Asistida con Soporte Parcial del Peso Corporal (EMA-SPPC) utilizando una cinta sin fin y la suspensión parcial del peso corporal mediante un arnés. El desarrollo de tecnología robótica para el EMA-SPPC ha llevado a la introducción de sistemas como el Lokomat® y el Gait T...

  2. Use of the gamma probe and of 99mTc-DMSA (V) in the identification of the neck recurrence of medullary carcinoma thyroid; Uso do gama probe e do 99mTc-DMSA (V) na identificacao de recorrencias cervicais de carcinoma medular de tireoide

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    Melo, Rosana Leite de; Kowalski, Luiz P.; Ubrich, Fabio F. [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Centro de Tratamento e Pesquisa. Dept. de Cirurgia de Cabeca e Pescoco e Otorrinolaringologia; Lima, Eduardo N. Pereira; Torres, Ivone C.G. [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Centro de Tratamento e Pesquisa. Dept. de Medicina Nuclear

    2003-03-01

    Medullary carcinoma of the thyroid, a malignant neoplasm of para follicular C cells, represent about 5-10% of thyroid tumors. The symptoms are related to local invasion and hormonal secretion. The clinical course is variable, from indolent cases to extremely aggressive. Many radionuclide imaging have been described to locate metastasis of medullary cancer. Tl-201 and Tc-99m (V)DMS A showed to be useful in the evaluation o persistent elevated serum calcitonin levels. On the other hand, the use of the 131 I-Mibg, that is the isotope more used, has not been demonstrating efficiency in identifying metastasis. Our objective is to report a case of a patient with medullary thyroid carcinoma in which the follow-up use DMS A(V) demonstrated a recurrence no identified for other methods. A 34-year-old man had a diagnosis of medullary thyroid carcinoma and has submitted a total thyroidectomy and neck lymph node dissection. He presented elevated serum calcitonin levels and DMS A(V) scintigraphy demonstrated focal area of pathologic uptake at the medline of the neck, but the surgical exploration was negative. He persisted with high calcitonin levels and it was used a new DMS A(V). On this occasion he was submitted to the radio-guided surgery that located the recurrence and it was confirmed with anatomo-pathologic exam. This case allowed to demonstrate that the use of radionuclide associated to the gamma-probe is promising, allowing a precise surgical approach. (author)

  3. Legibilidad de los documentos informativos en español dirigidos a lesionados medulares y accesibles por internet

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    M. Bea-Muñoz

    2015-08-01

    Full Text Available Fundamento: Los lesionados medulares y sus cuidadores tienen acceso en internet a folletos que pueden usar como complemento educativo frente a formas tradicionales de educación. El objetivo del estudio es valorar la legibilidad de los documentos informativos en español, obtenidos de internet y dirigidos a lesionados medulares. Material y métodos: Se realizó una búsqueda en el buscador Google con las siguientes palabras clave: recomendación, consejo, guía, manual, autocuidado, educación e información, añadiendo lesión medular, paraplejia o tetraplejia con cada uno de los términos. Analizamos los primeras 50 resultados de cada búsqueda. La legibilidad de los folletos se estudió con los índices de Flesch-Szigriszt y el grado INFLESZ, ambos disponibles en el programa INFLESZ. También se indicó el año de publicación, el país y el número de autores de los documentos obtenidos. Resultados: Se obtuvieron 16 documentos, elaborados entre 2001 y 2011. La legibilidad osciló entre 43,34 (algo difícil y 62 (normal, con un valor medio de 51,56 (algo difícil. Solo 4 folletos (25% presentaron un índice de Flesch-Szigriszt ≥ 55 (normal. No hay diferencias en la legibilidad según el año, los autores o el país de edición. Conclusiones: La legibilidad del 75% de los documentos estudiados es "algo difícil" según la escala INFLESZ. Estos resultados coinciden con estudios previos, tanto en español como en inglés. Si conseguimos mejorar la legibilidad de este tipo de documentos, su objetivo educativo será más fácil de alcanzar.

  4. Función Motriz y espasticidad tras la lesión medular incompleta. Nuevas herramientas de cuantificación.

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    Bravo Esteban-Herreros, Elisabeth

    2014-01-01

    Tras la lesión medular (LM) incompleta ciertas funciones motoras, sensitivas y autonómicas pueden recuperarse de manera espontánea tras el daño, si bien esta mejoría aparece de forma limitada. El objetivo de esta tesis doctoral se centra en cuantificar la presencia de cada uno de los signos asociados a la espasticidad y su interferencia específica sobre las actividades de la vida diaria, función motriz y marcha; así como evaluar el potencial diagnóstico de la coherencia intramuscular del TA p...

  5. Estudio de los Modos de Afrontamiento y el Apoyo Social percibido en pacientes afectos de Lesión Medular. Validación de la Escala HADS para screening de depresión en esta población

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    Villarreal Salcedo, Isabel; Ventura Faci, Tirso; Pelegrín Valero, C.

    2009-01-01

    Estudio longitudinal prospectivo, con una muestra formada por todos los pacientes ingresados de manera consecutiva en Unidad de Lesionados Medulares (ULME) de Enero 2007 a Abril 2008, n=59. Hipótesis del estudio: "La escala de Ansiedad y Depresión Hospitalaria (HADS) es válida para el screening de depresión en pacientes afectos de lesión medular (LM) Objetivos: "Identificar y analizar las principales variables clínicas y sociodemográficas asociadas a sufrir depresión tras LM";"determina...

  6. Papel del colesterol mitocondrial en la resistencia del carcinoma hepatocelular a la quimioterapia

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    Montero Boronat, Juan José

    2008-01-01

    [spa] DE LA TESIS: Distintas evidencias en la bibliografía apuntan al colesterol como uno de los componentes lipídicos celulares cuyos niveles están más alterados en la mayoría de células tumorales, y en particular, en el carcinoma hepatocelular. Se analizó la composición lipídica (niveles de colesterol y fosfolípidos) en mitocondrias de carcinoma hepatocelular, y en particular en los niveles de colesterol, que afectan a la fluidez de membrana y a la funcionalidad mitocondrial. La acumulación...

  7. Anotaciones respecto del nuevo Derecho Latinoamericano de la licitación pública: el horizonte de América del Norte (N.A.F.T.A.

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    León Cortiñas Peláez

    2014-11-01

    Full Text Available Contenido: Latinoamericanismo medular. Tribulaciones del Estado de Derecho. Un vuelco comparativo inesperado: la ley alemana de 1999. Alternativas menores a una rica vertiente propositiva

  8. Stating of cervical carcinoma using magnetic resonance imaging; Estadificacion del carcinoma de cervix por resonancia magnetica

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    Oleaga, L.; Vela, M. C.; Grande, J.; Cura del, J. L.; Grande, D. [Hospital de Basurto. Bilbao (Spain)

    1999-07-01

    The infiltration of the parametrium represents one of the most important factors that determine the prediction and treatment of cervical carcinoma. Our objetive is to evaluate the utility of magnetic resonance imaging (MRI) in the staging of cervical carcinomas, to establish the reliability of this technique and to carry out a comparative study of the sequences used to demonstrate the parametrial invasion. We have carried out a retrospective study on 44 patients diagnosed with cervix neoplasia, using clinical exploration and performing a biopsy. the MRI studies have been carried out using a 1 Tesla magnet and the sequences used have been SE T1, Se proton density (PD) and T2 and dynamic GRE after administering gadolinium intravenously in the axial and sagital projections. The stages determined by MRI have been compared to the anatomopathological stages of the surgical specimens in cases where surgery was carried out and with the clinical stage in cases where no radical surgery was carried out. A diagnosis value of MRI has been determined to demonstrate the parametrial invasion, comparing the SE T2 sequence with the dynamic GE sequence with gadolinium. We calculate the volume of the tumour in the MRI studies to evaluate the difference of the volume between patients with tumoral stages that are clinically surgical and not surgical. MRI determines the invasion of the parametrium with a sensitivity of 88.8%, a specificity of 80% a positive value of 76.1%, a negative predictive value of 90.9% and a reliability of 83.7%. For the SE T2 sequences the sensitivity was 86.6%, the specifity 80%, the posistive predictive value 81.25%, the negative predictive value 85.7% and the reliability 83.3%. For the dynamic GE sequence with intravenous gadolinium the sensitivity was 86.6%, the specifity 86.6%, the posistive predictive value 86.6%, the negative predictive value 86.6% and the reliability 86.6%. The use of the dynamic GE sequence after the intravenous administration of

  9. Síndrome de Gorlin-Goltz: manejo del carcinoma basocelular facial Gorlin-Goltz syndrome: management of facial basal cell carcinoma

    OpenAIRE

    Rocío Gilabert Rodríguez; Pedro Infante Cossío; Pablo Redondo Parejo; Eusebio Torres Carranza; Alberto García-Perla García; Domingo Sicilia Castro

    2013-01-01

    Introducción/objetivo: El síndrome de Gorlin-Goltz (SGG) es un trastorno hereditario autosómico dominante que predispone principalmente a la proliferación de tumores como los carcinomas basocelulares y queratoquistes maxilares. Está causado por la mutación del gen Patched localizado en el cromosoma 9. Los carcinomas basocelulares que aparecen en pacientes con el SGG suelen ser múltiples, de aspecto clínico polimórfico y sin predilección por el sexo, detectándose a veces a edades precoces de l...

  10. Sentimientos de los Familiares ante la Lesión Medular Feelings of the family in face of the spinal cord injury

    Directory of Open Access Journals (Sweden)

    Islene Víctor Barbosa

    2011-06-01

    Full Text Available El contexto de la lesión medular conduce a la familia a organizarse y redimensionar y dar otra dirección a su vida, para mejor comprender al individuo y aprender a convivir con las implicaciones de la lesión. Se objetivó conocer los sentimientos que permean la relación de atención de la familia de una persona con lesión medular, a la luz de la teoría de Jean Watson. Estudio cualitativo, realizado de septiembre a octubre de 2007, utilizando entrevista semiestructurada con 7 familiares cuidadores de personas con lesión medular ingresados en una institución de atención al trauma en la provincia Fortaleza-Ceará-Brasil. Las transcripciones fueron sometidas al análisis de contenido, siendo interpretadas por la Teoría del Cuidado Transpersonal de Watson. La investigación evidenció los sentimientos de los familiares despertados ante de ese tipo de lesión, destacándose la tristeza, la fe, la esperanza y la ansiedad y miedo. Se concluye que es necesario también resaltar la atención de la enfermería a la familia de aquellos acometidos por lesión medular.Spinal cord injury context takes family to reorganize and re-dimension its life style, for improve their comprehension about the individual and for learn how to live with his injury's complications. We aimed to know the feelings surrounding the relationship of the care of the family of a spinal cord injured person, supported by Watson's theory. It is a qualitative study achieved from September to October 2007, using a semi-structured interview with 7 family caregivers of Spinal cord injury patients at a reference institution on trauma assistance in city of Fortaleza-Ceará-Brazil. The speeches were submitted to Content Analysis, and interpreted by Jean Watson's Transpersonal Theory of Care. The research evidenced, among them, sadness, faith, hope, anxiety and fear. We concluded that it is also necessary to focus the Nursing care on the family of the spinal cord injured patients.

  11. Carcinoma de vesícula biliar “Hospital Universitario del Caribe”. Cartagena - Colombia (2007 -2010

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    Payares-Salgado Manuel A

    2010-06-01

    Full Text Available Objetivo: Realizar un análisis de los casos diagnosticados como carcinoma de vesícula biliar en el laboratorio de anatomía patológica del Hospital Universitario del Caribe.Material y métodos: Se revisaron las historias clínicas de los pacientes con diagnóstico histopatológico de carcinoma de vesícula biliar, que habían sido intervenidos por el servicio de cirugía general del Hospital Universitario del Caribe, en Cartagena, Colombia, entre el 1 de enero del 2007 al 30 de marzo del 2010.Resultados: Se identificaron diez casos con diagnóstico de carcinoma de vesícula biliar, en 538 piezas anatomopatológicas de vesícula biliar. El 90% correspondían a mujeres y 10% a varones. La edad promedio fue de 50.2 años. El 70% de los pacientes consultó por dolor abdominal inespecífico y de éstos el 90% con un tiempo de evolución inferior a 2 meses. El diagnóstico se sospechó en el momento del acto operatorio en el 60% de los casos y fue hallazgo incidental en el 30% de las colecistectomías. El tipo histológico más frecuente encontrado fue el adenocarcinoma bien y moderadamente diferenciado (90%. En el 20% de las historias clínicas no había datos de los estudios de apoyo diagnóstico. En el 80% restante, la ecografía abdominal fue el estudio de imagen más utilizado para el diagnóstico. La estadificación tumoral fue considerada predominantemente en estadios avanzados, IV y V, con compromiso del lecho hepático en el 50% de los casos.

  12. Estudi del proteasoma i altres dianes terapèutiques en el melanoma i el carcinoma d’endometri

    OpenAIRE

    Sorolla Bardají, Anabel

    2012-01-01

    Donada la resistència a la quimioteràpia que presenta el melanoma i el carcinoma d’endometri avançat, és important la investigació destinada a buscar dianes terapèutiques. En aquest treball hem investigat els efectes de d’anàlegs de la somatostatina (SA), d’inhibidors del proteasoma (PI) com Bortezomib, de l’inhibidor de receptors tirosina cinasa Sunitinib i la combinació de Sunitinib i Bortezomib en línies cel•lulars de melanoma. Aquesta combinació també l’hem testat en el carcinoma d’endome...

  13. Efeitos da natação sobre a independência funcional de pacientes com lesão medular Efectos de la natación sobre la independencia funcional de pacientes con lesión medular Effects of swimming on the functional independence of patients with spinal cord injury

    Directory of Open Access Journals (Sweden)

    Maurício Corte Real da Silva

    2005-08-01

    Full Text Available FUNDAMENTOS E OBJETIVO: O esporte tem um papel fundamental na reabilitação física de pacientes com lesão medular por ampliar as alternativas terapêuticas e favorecer a independência funcional. O estudo tem por objetivo conhecer os efeitos da natação sobre habilidades funcionais de pacientes com lesão medular. MÉTODOS: Foram selecionados 16 pacientes portadores de lesão medular, divididos em dois grupos: experimental e controle. Os grupos foram avaliados por meio da Medida de Independência Funcional (Escala FIM antes e após o procedimento que consistiu em sessões de natação realizadas duas vezes por semana durante quatro meses. RESULTADOS: Os dois grupos apresentaram mudanças nos cuidados com o corpo, transferências, escore motor total e escore total. O grupo experimental apresentou ganho maior nas transferências, escore motor total e escore total. CONCLUSÃO: A atividade de natação foi efetiva na melhora da condição física, trazendo benefícios motores sobre as habilidades funcionais dos participantes do grupo experimental.FUNDAMENTOS Y OBJETIVO: El deporte tiene un papel fundamental en la rehabilitación física de pacientes con lesión medular por ampliar las alternativas terapéuticas y favorecer la independencia funcional. El estudio tiene por objeto conocer los efectos de la natación sobre las habilidades funcionales de los pacientes con lesión medular. MÉTODOS: Fueron seleccionados 16 pacientes portadores de lesión medular divididos en dos grupos: experimental y control. Los grupos fueron evaluados por medio de la Medida de Independencia Funcional (Escala FIM antes y después de un procedimiento que consistió en sesiones de natación realizadas dos veces por semana durante cuatro meses. RESULTADOS: Los dos grupos presentaron cambios en los cuidados con el cuerpo, transferencias, puntaje motor total y puntaje total. El grupo experimental presentó ganancia mayor en las transferencias, puntaje motor total y

  14. Dor neuropática central após lesão medular traumática: capacidade funcional e aspectos sociais Dolor neuropático central después de lesión medular traumática: capacidad funcional y aspectos sociales Central neuropathic pain after traumatic spinal cord injury: functional capacity and social aspects

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    Janaina Vall

    2005-12-01

    Full Text Available Estudo de caso comparativo com o objetivo de avaliar a capacidade funcional e os aspectos sociais de dois pacientes, ambos com lesão medular traumática, sem e com dor neuropática central associada, respectivamente. Para avaliar a capacidade funcional, foi utilizado como instrumento o Functional Independence Measure ou Escala de Independência Funcional. E para avaliar os aspectos sociais foi construído o ecomapa de cada paciente, preconizado pelo modelo Calgary de avaliação de famílias. Ambos foram aplicados no domicílio do paciente. Os resultados mostraram que o paciente com dor neuropática central secundária à lesão medular possui baixa capacidade funcional e precária rede social de apoio, quando comparado com o paciente com as mesmas condições, porém sem dor associada.Estudio de caso comparativo con el objetivo de evaluar la capacidad funcional y los aspectos sociales de dos paciente, ambos con lesión medular traumática, sin y con el dolor neuropático central, respectivamente. Para evaluar la capacidad funcional, se usó como instrumento la Escala de Independencia Funcional. Y para evaluar los aspectos sociales, el ecomapa de cada paciente fue construido, preconizado por el modelo Calgary de evaluación de familias. Los dos furon aplicados en la casa del paciente. Los resultados mostraron que el paciente con dolor neuropatico central secundario a la lesión medular posee capacidad funcional baja y precaria red social de apoyo, cuando comparado con el paciente con las mismas condiciones, pero sin el dolor asociado.Comparative study of case with the aim of evaluating the functional capacity and social aspects of two patients, both with traumatic spinal cord injury, without and with central neuropathic pain associated, respectively. To evaluate the functional capacity it was used as instrument Functional Independence Measure. And to evaluate the social aspects the ecomap of each patient one it was built, extolled by the model

  15. [I costi farmacologici della terapia di conversione con farmaci biologici nel carcinoma del colon-retto con metastasi epatiche].

    Science.gov (United States)

    Giuliani, Jacopo; Bonetti, Andrea

    2016-08-01

    Riassunto. Lo scopo di questo studio è quello di valutare i costi dei farmaci (con particolare riferimento alle terapie con farmaci biologici) utilizzati nella terapia di conversione in una popolazione non selezionata di pazienti affetti da carcinoma del colon-retto in stadio avanzato, al fine di ottenere una resezione epatica R0. In questa rassegna sono stati selezionati i report completi e gli aggiornamenti di tutti gli studi clinici randomizzati (di fase II e fase III) che confrontassero almeno 2 regimi di terapia con farmaci biologici in prima linea in pazienti affetti da carcinoma del colon-retto in stadio avanzato di malattia. I costi dei farmaci sono stati ricavati dalla nostra Farmacia Ospedaliera e sono espressi in euro (€). Il nostro studio inizia con la valutazione di 683 abstract. 48 tria sono stati considerati adeguati per una successiva analisi. Una valutazione più approfondita ha portato all'esclusione di 37 trial, lasciando alla valutazione finale 11 studi clinici randomizzati (3 trial di fase II, per un totale di 522 pazienti, e 8 studi di fase III, per un totale di 7191 pazienti). I costi dei farmaci utilizzati nella terapia di conversione aumentano con la sostituzione del 5-fluorouracile con la capecitabina e, in misura maggiore, con l'introduzione degli agenti biologici. In questo lavoro sono presentati due punti chiave. Primo, i costi degli agenti farmacologici utilizzati nei regimi di prima linea a base di agenti biologici più comunemente utilizzati nel trattamento del carcinoma del colon-retto in stadio avanzato sono molto variabili. Secondo, i dati di efficacia dei regimi pubblicati, in termini di tassi di resezione, dipendono dalla selezione dei pazienti, dalle caratteristiche del tumore e dal tipo di schema di terapia. PMID:27571559

  16. Síndrome de Gorlin-Goltz: manejo del carcinoma basocelular facial Gorlin-Goltz syndrome: management of facial basal cell carcinoma

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    Rocío Gilabert Rodríguez

    2013-03-01

    Full Text Available Introducción/objetivo: El síndrome de Gorlin-Goltz (SGG es un trastorno hereditario autosómico dominante que predispone principalmente a la proliferación de tumores como los carcinomas basocelulares y queratoquistes maxilares. Está causado por la mutación del gen Patched localizado en el cromosoma 9. Los carcinomas basocelulares que aparecen en pacientes con el SGG suelen ser múltiples, de aspecto clínico polimórfico y sin predilección por el sexo, detectándose a veces a edades precoces de la vida y afectando incluso a zonas no expuestas a la luz solar. Muestran un comportamiento clínico variable, si bien en ocasiones pueden ser muy agresivos, sobre todo a nivel facial. Con el fin de estudiar el comportamiento de los carcinomas basocelulares en los pacientes con SGG se ha realizado un estudio de los pacientes tratados en nuestro hospital durante el periodo comprendido entre 2001 y 2011 y que cumplían criterios de la enfermedad. Material y métodos: Se incluyeron 11 pacientes con diagnóstico clínico y/o genético de SGG. Se estudió la distribución según edad y sexo, manifestaciones clínicas, características histológicas, técnica quirúrgica empleada, presencia de recidiva y evolución de los pacientes. Resultados: Un 36% de los pacientes presentaron carcinomas basocelulares en la cara. El número de tumores por paciente osciló entre 9 y 21. El tratamiento preferido fue la exéresis quirúrgica, si bien todos los pacientes desarrollaron nuevas lesiones y recidivas que requirieron varios procedimientos. El estudio histológico reveló un contacto o proximidad del tumor con los márgenes quirúrgicos en el 28% de las lesiones. Conclusiones: En la literatura no hay evidencia suficiente para determinar el tratamiento de elección entre los distintos métodos disponibles para el manejo del carcinoma basocelular en el SGG. Es necesario un enfoque preventivo evitando la exposición al sol.Introduction/objective: Gorlin Goltz

  17. Sexualidade masculina pós-lesão vertebro-medular

    OpenAIRE

    Cardoso, Jorge Manuel Santos

    2003-01-01

    Tesede Doutoramento Psicobiologia apresentada ao Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto As lesões vertebro-medulares (LVM) provocam um grau variável de perturbação das funções motoras e sensoriais, acompanhado por um conjunto de alterações psicológicas associadas à perda ocorrida. Influenciada quer pelas especificidades da lesão, quer pela readaptação psicológica, a sexualidade dos indivíduos LVM constitui uma dimensão que não pode ser ignorada pelos elemen...

  18. Lesiones medulares y discapacidad: revisión bibliográfica

    OpenAIRE

    Claudia Patricia Henao-Lema; Julio Ernesto Pérez-Parra

    2010-01-01

    La lesión medular es una entidad neurológica causante de importantes procesos de discapacidad. Su incidencia en el país puede estar cercana a los mayores estimativos mundiales debido a las condiciones actuales de violencia. El aumento de la expectativa de vida de esta población —gracias a los avances tecnológicos y científicos en prevención, atención y manejo de complicaciones— lleva a la necesidad de proveer servicios de rehabilitación integrales que trasciendan los aspectos func...

  19. Lesão medular no Centro de Reabilitação e Readaptação Dr. Henrique Santillo (CRER- GO Lesión medular en el Centro de Rehabilitación y Readaptación Dr. Henrique Santillo (CRER-GO Spinal cord injury in Dr. Henrique Santillo Rehabilitation and Readaptation Center (CRER-GO

    Directory of Open Access Journals (Sweden)

    Natália Ribeiro de Oliveira Custódio

    2009-09-01

    Full Text Available OBJETIVO: avaliação epidemiológica de pacientes com diagnóstico de lesão medular internados para reabilitação na enfermaria do Centro de Reabilitação e Readaptação Dr. Henrique Santillo (CRER em Goiânia, Goiás. MÉTODOS: estudo epidemiológico retrospectivo baseado na coleta de dados dos prontuários médicos dos pacientes internados no período de Março de 2007 a Março de 2009. RESULTADOS: foram avaliados 208 pacientes, com predomínio do sexo masculino (78,85% e idade média de 35,3 anos. O déficit neurológico mais prevalente foi paraplegia (64,90%, sendo 54,33% dos pacientes classificados como ASIA A (lesão completa de acordo com a classificação da American Spinal Injury Association (ASIA. O tempo médio de lesão até a admissão no CRER foi de 129,7 dias, e o tempo médio de internação para reabilitação destes pacientes foi de 44,9 dias. A principal etiologia da lesão medular foi traumática, sendo 44,70% representadas por acidente de trânsito. A complicação mais comum na internação foi infecção do trato urinário. CONCLUSÃO: os dados epidemiológicos de pacientes com lesão medular, admitidos no CRER para reabilitação, se mostraram em conformidade com dados já descritos na literatura, demonstrando cada vez mais a importância da divulgação e realização de campanhas de prevenção do trauma raquimedular. Assim como a necessidade do encaminhamento precoce destes pacientes ao centro de reabilitação, uma vez que a grande maioria é jovem, com sequelas neurológicas graves e altamente incapacitantes.OBJETIVO: evaluación epidemiológica de pacientes con diagnóstico de lesión medular internados para rehabilitación en urgencias del Centro de Rehabilitación y Readaptación Dr. Henrique Santillo (CRER en Goiânia, Goiás. MÉTODOS: estudio epidemiológico retrospectivo con base en la recogida de datos de las historias médica de los pacientes internados en el periodo de Marzo de 2007 a Marzo de 2009

  20. Historia natural del carcinoma hepatocelular en una cohorte de pacientes de un hospital comarcal Natural history of hepatocellular carcinoma in a cohort of patients from a county hospital

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    M. Vergara

    2008-11-01

    Full Text Available Introducción: el carcinoma hepatocelular (CHC es una neoplasia con una elevada incidencia y una alta mortalidad. Objetivo: nuestro objetivo es la descripción de la historia natural de una cohorte de pacientes con CHC e identificar variables asociadas a supervivencia. Material y métodos: estudio retrospectivo y descriptivo de pacientes diagnosticados de CHC entre 1995-2002. Las variables cualitativas se expresaron mediante frecuencias y porcentajes y las cuantitativas con mediana y desviación típica. La supervivencia se estimó mediante el método de Kaplan Meyer y la prueba de Log Rank. Resultados: se analizaron un total de 154 pacientes con CHC. La ratio hombre-mujer fue de 2,9/1. La edad media de 68 ± 9 años. El 82% de los pacientes fueron exitus en un tiempo medio de seguimiento de 28 meses. La mediana de supervivencia fue de 21,5 meses (IC 95%: 16,98-26,04. Se realizó tratamiento con intención curativa en un 40,3% y el resto tratamiento paliativo. Las variables asociadas a la supervivencia fueron: presencia o no de ascitis, el número de lesiones en el momento del diagnóstico y si el tratamiento realizado fue con intención curativa o no. No hubieron diferencias estadísticamente significativas respecto a: sexo, edad, etiología de la cirrosis y estadio de Child en el momento del diagnóstico. Conclusiones: los factores asociados a una menor supervivencia en los pacientes con carcinoma hepatocelular fueron la presencia de ascitis y el número de lesiones en el momento del diagnóstico. La realización de tratamiento con intención curativa se asocia a una mayor supervivencia.Background: hepatocellular carcinoma (HCC is a cancer with high incidence and mortality. Objective: our aim was to describe the natural history of a patient cohort with HCC, and to identify the factors associated with survival. Patients and methods: a retrospective and descriptive study of patients diagnosed with HCC between 1995 and 2002. Qualitative variables

  1. Riesgo de recurrencia ganglionar y valoración evolutiva en pacientes con carcinoma de mama en estadios precoces y sometidas a la biopsia selectiva del ganglio centinela

    OpenAIRE

    Domènech Vilardell, Anna

    2011-01-01

    ANTECEDENTES DEL TEMA: El estado ganglionar axilar es el factor pronóstico más importante para determinar la supervivencia y la recurrencia en el carcinoma de mama, puesto que es conocido que la afectación axilar en estas pacientes, disminuye la supervivencia a los 5 años del 85-95 % al 55-70 % y conlleva a que presenten metástasis a distancia con más frecuencia . De todos modos, la introducción y amplia utilización del cribado mamográfico está aumentando la detección de tumores incipientes ...

  2. Paravertebral cutaneous hemangiosarcoma in dog causing medular compression / Hemangiossarcoma cutâneo paravertebral em cão causando compressão medular

    Directory of Open Access Journals (Sweden)

    Ana Paula Frederico Rodrigues Loureiro Bracarense

    2010-07-01

    Full Text Available A seven-year-old male Scottish terrier was examined at the Veterinary Hospital of the Universidade Estadual de Londrina due to a toracolumbar syndrome classified as V degree and a mass in lumbar region back right of slow growth with evaluation of two months. Myelography showed an interruption of the column of contrast between the 11th and 12th thoracic vertebrae. A hemilaminectomy was performed in this region. Spinal cord compression at this location was not observed, however during the caudal enlargement of hemilaminectomy it was visualized in the region of the fourth lumbar vertebrae, a spinal cord deviation to the left, due to the presence of a reddish mass at the right side that was diagnosed as a tumor infiltration in the vertebrae with cord compression. Surgical removal with appropriate margin was not possible. In histology, the tumor was classified as hemangiosarcoma. This report emphasizes the importance of considering the possibility of cancer as differential diagnosis of paraplegias, even in acute clinical changes.Um cão macho, Scottish Terrier, de sete anos foi atendido no Hospital Veterinário da Universidade Estadual de Londrina por apresentar paraplegia grau V e um nódulo em região dorso lombar direita de crescimento lento, com evolução de dois meses. Foi realizado mielografia, visibilizando-se interrupção na coluna de contraste entre as vértebras torácicas 11ª e 12ª. Assim, procedeu-se à hemilaminectomia nesta região, não sendo constatado compressão medular, procedendo-se a ampliação caudal da abertura da lâmina vertebral T12. Na região da quarta vértebra lombar observou-se um desvio da medula espinhal para o lado esquerdo devido à presença de uma massa de coloração avermelhada proveniente do lado direito, diagnosticando-se infiltração tumoral em vértebras com compressão medular, não sendo possível sua remoção cirúrgica. Na histologia classificou-se o tumor como hemangiossarcoma. Este relato

  3. Padronização e avaliação histológica de um modelo experimental de lesão medular

    OpenAIRE

    José Ademar Villanova Junior; Rosangela Locatelli-Dittrich; Letícia Fracaro; Carmen Lúcia Kuniyoshi Rebelatto; Luis Guilherme Achcar Capriglione; Paulo Roberto Slud Brofman; Liv Cristina Miara; Corinne de Alcântara Fernandes Nascimento

    2014-01-01

    A lesão medular é incapacitante, irreversível e de custo econômico e social elevado. Neste estudo, objetivou-se padronizar um modelo de lesão medular, que produza paraplegia, com o uso de cateter e avaliar histologicamente a efetividade da lesão para estudos com terapia celular. Foram realizadas as lesões medulares em ratos Wistar, utilizando-se o cateter Fogarty n.3 e compressão na região toracolombar (T8-T9) durante 5 minutos. Foram estudados três grupos: grupo A, animais controle sem lesão...

  4. Carcinoma bronquioloalveolar, ¿Diagnóstico precoz?: Experiencia 1994-1997 en el Instituto Nacional del Tórax BRONCHIOALVEOLAR CARCINOMA EARLY DIAGNOSIS?: STUDY AT INSTITUTO NACIONAL DEL TORAX 1994-1997

    Directory of Open Access Journals (Sweden)

    JAIME GUACHALLA U.

    2002-04-01

    Full Text Available El carcinoma bronquioloalveolar (CABA se presenta inicialmente en etapa de nódulo periférico, asintomático y estable por algunos años. En esta etapa el tratamiento tiene una sobrevida de 75 a 80% a cinco años. En los países desarrollados su diagnóstico se logra en esta etapa hasta en un 50% de los pacientes. La fase de microdiseminación canalicular corresponde a un estadio difuso de mal pronóstico. Nuestro propósito fue evaluar el diagnóstico precoz del CABA en el Instituto Nacional del Tórax (INT. Se realizó una revisión retrospectiva de estos pacientes usando la base de datos de cáncer pulmonar del INT durante 1994-1997. Se encontró 673 pacientes con cáncer pulmonar, de los cuales 15 (2,2% eran del subtipo CABA confirmado por citología y/o histología. El promedio de edad de estos pacientes fue 64 años. La relación masculino/femenino = 1,1 y 56,2% eran fumadores. En etapa de nódulo ingresaron dos pacientes con CABA (13,3%, que fueron tratados con lobectomía, sobreviviendo 56 y 30 meses respectivamente. El promedio de sobrevida de los 13 pacientes con tratamiento paliativo fue 9 meses. En este estudio los pacientes con CABA en cuanto a promedio de edad, distribución por sexo y hábito tabáquico son coincidentes con los de otras series. Sin embargo, el porcentaje de pacientes diagnosticados en etapa de nódulo periférico es claramente menor a los registrados en países desarrollados (13 versus 50%. Este hecho muestra la importancia del tamizaje oportuno del paciente con CABA para encontrarlos en la etapa más precoz. La frecuencia de pacientes con CABA diagnosticados en etapa de nódulo periférico podría reflejar la calidad de la pesquisa del cáncer pulmonar en cualquier centro hospitalarioBronchioloalveolar Carcinoma (BAC at an early stage is presented as an asymptomatic peripheral nodule being stable for some years. Surgical treatment has up to 80% five years survival at this stage. Up to 50% of patients are

  5. Neuroelectroestimulación medular en el síndrome doloroso regional complejo Tipo I: Estudio de casos Spinal cord stimulation in the Complex Regional Pain Type I: Cases report

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    A. Gómez-García de Paso

    2007-12-01

    Full Text Available Presentamos 5 pacientes con diagnóstico de Síndrome Doloroso Regional Complejo Tipo I que han sido tratados mediante neuroestimulación medular. El tiempo de seguimiento medio fue de 6 años con un resultado bueno. No se presentaron complicaciones con los neuroestimuladores ni infecciones del sistema en ningún caso. El objetivo principal del tratamiento rehabilitador es conseguir la funcionalidad máxima con un tratamiento individualizado y adaptado a las necesidades de cada paciente incluyendo los fármacos, agentes tópicos, administración de sustancias epidurales y terapia psicológica. La neuroestimulación medular es un método terapéutico útil para el tratamiento del dolor y un medio de ofrecer alivio persistente a los pacientes cuando otros tratamientos han fracasado.We presented 5 patients with diagnosis of Reflex Sympathetic Dystrophy that they have been treated with spinal cord stimulation. The mean follow up was 6 years with a good result. Complications with the neuro-stimulation nor infections of the system in any case did not appear. The primary target of the rehabilitation treatment is to achieve the highest functionality with an individualized treatment and adapted to the necessities of each patient including drugs, topical agent, administration of epidurals substances and psychological therapy. The Spinal cord neuro-stimulation is a useful therapeutic method for the treatment of the pain and means to offer persistent lightening to the patients when other treatments have failed.

  6. Tumoral response factors after radiofrequency ablation of hepatocellular carcinoma in cirrhotic liver Factores de respuesta tumoral tras ablación mediante radiofrecuencia del carcinoma hepatocelular sobre cirrosis

    Directory of Open Access Journals (Sweden)

    J. Calleja Kempin

    2005-10-01

    Full Text Available Objective: hepatocellular carcinoma (HCC ablation by radiofrequency (RFA is a novel technique with a great variety of methods whose efficacy and predictive factors have not been completely studied. Some of the main predictive factors in this type of treatment are analyzed in the present study. Patients and methods: ninety-three patients with hepatocellular carcinoma over cirrhosis, and with no indication for surgical resection were treated by RFA. Two different types of electrodes were used for RFA (refrigerated-"Cool-Tip" and perfusion with saline solution, the approach was percutaneous, by laparoscopy or laparotomy. Results: overall survival at 1, 2 and 3 years was 88, 81, and 76%, with a free-disease survival (FDS of 66, 31 and 17%, respectively. For tumors less than 3 cm, FDS at 1,2 and 3 years was 74, 44 and 30%, while for more than 3 cm in size FDS was 55, 12 and 0% (p = 0.02. FDS for HCC with one nodule was 70, 36 and 22%, and for more than one nodule it decreased to 50, 17 and 0% at 1, 2 and 3 years, respectively (p = 0.07. Surprisingly, the method employed for RFA has a main influence in FDS, with 0% at 3 years for perfusion electrodes and 26% for cool-tip electrodes at the same period. Conclusions: in this series, overall survival at three years was relatively high; however, tumoral size, number of nodules and RFS method were independent variables associated with disease-free survival.Objetivo: la ablación por radiofrecuencia del hepatocarcinoma (ARF es una técnica de reciente adquisición, cuya eficacia y factores predictivos no han sido suficientemente evaluados. El presente estudio fue diseñado para este análisis. Pacientes y métodos: se han tratado 93 pacientes con hepatocarcinoma sobre hígado cirrótico sin criterios de resección ni de trasplante hepático. El tratamiento se realizó mediante abordaje percutáneo, laparoscópico o mediante laparotomía con dos tipos de electrodos de radiofrecuencia, electrodo refrigerado y

  7. Esquistossomose medular

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    Edístio Pondé

    1960-06-01

    Full Text Available Os autores relatam o caso de um paciente que se apresentara com paraplegia flácida, distúrbios esfincterianos e alterações das sensibilidades superficiais, evoluindo no espaço de pouco mais de um ano para o resultado letal. No curso da doença o paciente apresentara oscilações térmicas que variavam de 37 a 38°, atingindo às vêzes 40°C. Surtos diarréicos entrecortavam ou substituíam às vêzes tenaz obstipação. Entre os vários exames de laboratório, assinalaram-se leucocitose com neutrofilia, presença de ovos de S. mansoni nas fezes. Foi efetuada terapêutica à base de antibióticos, vitaminas e radioterapia profunda, além de derivados de antimônio, sem resultado positivo. Na autópsia foram encontradas lesões granulomatosas fibrosantes esquistossomóticas localizadas nos cornos anteriores da medula, na comissura cinzenta e na substância branca dos funículos anteriores e laterais, com exclusão dos cordões posteriores. Os autores assinalam a concordância dos dados clínicos com os resultados do exame an átomo-patológico e discutem o problema do diagnóstico clínico e do trajeto dos ovos de S. mansoni, até chegarem à medula.

  8. Influencia del tratamiento radiológico locorregional pretrasplante en la evolución de los pacientes trasplantados por cirrosis hepática con carcinoma hepatocelular

    OpenAIRE

    Cantos Pallares, Miriam

    2015-01-01

    El carcinoma hepatocelular (CHC) es el tumor maligno hepático primario más frecuente y representa la tercera causa de cáncer en el mundo. Su incidencia está aumentando considerablemente en las últimas décadas1. Este tumor se desarrolla habitualmente sobre hígados cirróticos y la resección quirúrgica sólo es posible en menos del 30% de los casos2. El trasplante hepático (TH) es el único tratamiento potencialmente curativo y su realización en pacientes con carcinoma hepatocelular que c...

  9. Endorectal coil MRI in local staging of prostate carcinoma. Comparative assessment with histologic macro section in 40 cases; La Risonanza Magnetica con bobina endorettale nella stadiazione locale del carcinoma prostatico. Confronto con macrosezioni istologiche in 40 casi

    Energy Technology Data Exchange (ETDEWEB)

    Torricelli, P.; Iadanza, M.; De Santis, M.; Pollastri, C.A. [Modena Univ. (Italy). Dipt. di Scienze Mediche, Oncologiche e Radiologiche. Dipt. di Chirurgia. Div. di Urologia; Cesinari, A.M.; Trentini, G.; Romagnoli, R. [Modena Univ. (Italy). Dipt. di Scienze Mediche, Oncologiche e Radiologiche. Dipt. di Scienze Morfologiche e Medico Legali

    1999-06-01

    Endorectal coil MRI is widely used in the diagnostic workup of prostate cancer, but diagnostic accuracy rates reported in the literature are quite variable. The authors report them personal experience with endorectal coil MRI in the local staging of prostate carcinoma. MRI showed moderate overall and particularly MRI had good accuracy in detecting seminal vesicle involvement but moderate sensitivity and specificity in demonstrating capsular infiltration and apex involvement. Due to its high cost, MRI should not be routinely used in prostate cancer standing but should be reserved to the patient whose clinical and serological data suggest extra prostatic tumor spread, whose preoperative demonstration could avoid non curative surgery. [Italian] La RM con bobina endorettale viene oggi ampiamente impiegata nella stadiazione del carcinoma prostatico, sebbene i risultati relativi al suo impiego siano tuttora piuttosto difformi tra i diversi autori. Scopo del presente lavoro e' presentare la personale esperienza relativo all'impiego della RM con bobina endorettale nella stadiazione locale del carcinoma prostatico. La RM ha consentito di ottenere discreti risultati e soprattutto di evidenziare con buona accuratezza l'invasione delle vescicole seminali, mentre ha presentato sensibilita' e specificita' inferiori nella valutazione della penetrazione capsulare e dell'apice prostatico. Visti gli elevati costi della metodica si conclude che la RM non possa essere considerata indagine abituale nella stadiazione del carcinoma prostatico, ma possa essere riservata alla valutazione di quei pazienti ove, sulla base di altri dati clinici, bioumorali o strumentali, sia ritenuta probabile l'estensione extracapsulare macroscopica della neoplasia, evento che, confermato preoperatoriamente, puo' costituire criterio di esclusione della terapia chirurgica.

  10. Diagnósticos de enfermagem e proposta de intervenções para pacientes com lesão medular Diagnósticos de enfermería y propuesta de intervenciones para pacientes con lesión medular Nursing diagnoses and interventions proposal al for patients with spinal cord lesion

    Directory of Open Access Journals (Sweden)

    Clélia Regina Cafer

    2005-12-01

    la unidad de estudio, con la finalidad de identificar los diagnósticos de enfermería. Las intervenciones fueron propuestas por las autoras y sometidas a la evaluación de dos especialistas. RESULTADOS: Fueron identificados 15 diagnósticos de enfermería prevalentes, para los cuales se propusieron 26 intervenciones de enfermería. CONCLUSIÓN: Los resultados del estudio servirán de subsidio a las enfermeras para el cuidado de pacientes con lesión medular, auxiliándolos y contribuyendo en su autonomía, a través de las intervenciones propuestas.INTRODUCTION: Spinal cord lesions constitute very serious events that occur mostly among young people. Providing care to these patients is a complex task because they are greatly dependent on nursing staff and require a very carefully designed plan of care. The purpose of this study was to contribute ways to design a quality plan of care to attend these patients. OBJECTIVES: To identify nursing diagnoses according to the NANDA for patients with spinal cord lesions from an Orthopedic and Trauma Unit, and to propose appropriate nursing interventions according to the NIC. METHODS: This study used a descriptive and prospective research design. The sample consisted of 10 patients with spinal cord lesions. Data were colleted from January, 2000 to July, 2002 using a specific assessment tool. Data analysis led the researchers to propose nursing diagnoses which were validated by two clinical nursing specialists. RESULTS: Fifteen prevalent nursing diagnoses were identified and 26 nursing interventions were proposed. CONCLUSION: The results can be used to assist nurse to provide quality care for patients with spinal cord lesions, so as to improve the patients independence.

  11. Repercusión de las lesiones medulares traumáticas en la dinámica vesical: perspectivas de seguimiento

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    Héctor Alfonso Solano Moreno

    2013-01-01

    Full Text Available Las lesiones en la médula espinal representan un porcentaje importante como causa de discapacidad en México y en el mundo, siendo la tercera causa con un porcentaje superior a 25%. Este tipo de pacientes sufre múltiples complicaciones y una de ellas es la que corresponde al sistema urológico al que muchas veces no se le da un seguimiento de manera regular. Dentro de las lesiones de las vías neurológicas, que inervan a la vejiga, pueden afectar a uno o varios aspectos de la fisiología, ya sea su fase de llenado, de almacenamiento o de vaciamiento, lo anterior según el área nerviosa alcanzada y la naturaleza de la lesión; estas lesiones deben ser manejadas por el mismo urólogo que debe seleccionar la opción terapéutica adecuada en su ámbito de competencia, tomando en cuenta los pros y contras de cada una de ellas, ya que esto tendrá una repercusión en la calidad de vida del paciente, así como continuar un programa de seguimiento para la detección de complicaciones de manera oportuna. Particularmente el cateterismo urinario es pilar fundamental para el manejo de las lesiones medulares postraumáticas, ya que puede contribuir a la disminución de las complicaciones.

  12. La diagnosi molecolare del carcinoma vescicale: un aiuto per la prognosi e la terapia

    OpenAIRE

    Silvana Virgilio

    2006-01-01

    L’avanzamento delle conoscenze della biologia molecolare dei tumori ha portato all’individuazione di marcatori bio-molecolari utili per la diagnosi, la prognosi e la terapia degli stessi. Il presente articolo evidenzia in particolare i markers coinvolti nella cancerogenesi vescicale. Il carcinoma alla vescica è il quarto tra i tumori più comuni nell’uomo seguito da quello alla prostata, al polmone, e al colon; la sua insorgenza dipende da una combinazione di fattori genetici e ambientali tra ...

  13. A escala de Waterlow aplicada em pessoas com lesão medular La escala de Waterlow aplicada en personas con lesión medular The Waterlow scale applied in people with spinal cord injury

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    Rita Monica Borges Stüdart

    2011-12-01

    Full Text Available Objetivos: Avaliar os fatores de risco para úlceras por pressão em pessoas hospitalizadas por lesão medular, utilizando a Escala de Waterlow e as orientações prestadas para os pacientes antes e depois do aparecimento das úlceras. Método: Estudo transversal, com 60 pacientes, realizado em um hospital da cidade de Fortaleza (Ceará-Brasil. A coleta de dados efetuou-se de maio a outubro de 2008 por meio da utilização da escala de Waterlow. Para a análise foram utilizados: Teste de Kolmogorov-Smirnov, Coeficiente de correlação de Pearson e Coeficiente de correlação de Spearman. Resultados: O fator de risco mais significante para o desenvolvimento da úlcera por pressão foi a mobilidade física prejudicada associada ao longo tempo de internação. A presença de acompanhante foi outro achado importante, pois dos 19 pacientes que não desenvolveram úlcera por pressão todos tinham acompanhantes. Foi constatado também que 90% dos pacientes não receberam nenhum tipo de orientação antes do advento da úlcera por pressão, e que apenas 31% receberam orientações depois do aparecimento da mesma. Conclusões: A variável mais significativa em relação ao risco para desenvolver úlcera por pressão foi a mobilidade física prejudicada, visto que os pacientes eram dependentes de cadeira de rodas ou inertes no leito. A maioria não recebeu orientação antes do aparecimento da úlcera por pressão e somente alguns receberam orientação. Assim o estudo revelou-se eficaz na avaliação dos fatores de risco bem como para o conhecimento das orientações de enfermagem recebidas.Objetivos: Evaluar los factores de riesgo de úlceras por presión en personas hospitalizadas por lesión medular, utilizando la Escala de Waterlow y las instrucciones dadas a los pacientes antes y después de la aparición de las úlceras. Método: Estudio transversal, con 60 pacientes, realizado en un hospital de la ciudad de Fortaleza (Ceará-Brasil. La recolecci

  14. Asociación de electrones de alta energía y rayos gamma para el tratamiento no mutilante del carcinoma de la mama de la mujer

    OpenAIRE

    Pera Fàbregas, Joan

    1994-01-01

    [spa] En esta tesis se estudia el resultado del tratamiento efectuado entre 1984 y 1992 a 554 pacientes que padecen un carcinoma infiltrante de la mama. El tratamiento consistió en lo siguiente: Extirpación amplia del tumor y vaciado de la axila, telerradioterapia sobre la mama a 45 Gy y sobredosis a la cicatriz y al pezón de 10 a 20 Gy utilizando telerradioterapia con electrones o braquiterapia con Iridio 192. Se administró hormonoterapia o quimioterapia según los protocolos de los centros d...

  15. Valor de la PET FDG en la estadificación mediastínica del carcinoma pulmonar no microcítico

    OpenAIRE

    Rosado Rodríguez, Joel

    2011-01-01

    La tomografia per emissió de positrons amb 18fluorodesoxiglucosa (PET-FDG) s'ha implantat com a tècnica d'estudi i estadificació d'elecció als pacients amb diagnòstic de carcinoma pulmonar no microcrític (CPNM) susceptibles de tractament quirúrgic. Mètodes: Per valorar l'eficàcia de la PET FDG realitzem un estudi retrospectiu incloent els pacients intervinguts al nostre centre entre setembre del 2007 i abril del 2009. Resultats: La PET-FDG va mostrar una sensibilitat i especificitat de 56% i ...

  16. Factores asociados al empoderamiento en personas con lesión medular tras un accidente de tráfico

    OpenAIRE

    Raquel Suriá Martínez

    2015-01-01

    Objetivo: Analizar la capacidad de empoderamiento de un grupo de personas con lesión medular en función de la edad, el sexo, la condición funcional y la edad en la cual adquirieron la lesión. Métodos: Participaron 94 personas con lesión medular (42 tetrapléjicos y 52 parapléjicos), que contestaron la versión española adaptada de la Escala de Rogers, Chamberlin, Ellison y Crean (1997), diseñada para medir el empoderamiento. Resultados: Los análisis indicaron niveles más altos de esta capacidad...

  17. DNA aneuploidy in colorectal adenomas: Role in the adenoma-carcinoma sequence Aneuploidía del ADN en adenomas colónicos: Papel en la secuencia adenoma-carcinoma

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    M. Alcántara Torres

    2005-01-01

    Full Text Available Introduction: aneuploidy has been observed in 6-27% of lesions known to be precursors of colorectal cancer, such as adenomas or ulcerative colitis. It has been suggested that aneuploidy may predispose to malignancy in these cases. However, its role in the adenoma-carcinoma sequence has not been definitely established. The objective of this study was to assess the incidence of aneuploidy in colon adenomas, as well as to study its possible role in the adenoma-carcinoma sequence. Material and methods: the study was performed on a series of 57 large bowel adenomas measuring 10 mm or more, collected from 54 consecutive patients. All specimens were obtained either by endoscopic or by surgical resection. There were 49 adenomas with low-grade dysplasia, two with high-grade dysplasia, two intramucous carcinomas, and four microinvasive carcinomas. A flow cytometric DNA analysis was performed in fresh specimens following Vindelov´s method. Results: aneuploid DNA was detected in five out of 49 low-grade dysplasia adenomas (10%, in all four high-grade dysplasia adenomas or intramucous carcinomas (100%, and in three out of four microinvasive carcinomas (75%. The association between aneuploidy and high-grade dysplasia adenomas, intramucous, or microinvasive carcinoma was statistically significant (p Introducción: en patología benigna de intestino grueso precursora del cáncer colorrectal, como adenomas o colitis ulcerosa, se ha observado aneuploidía en el 6-27% de los casos y se ha sugerido que su presencia predispone al desarrollo de malignidad. Sin embargo, su papel en la secuencia adenoma-carcinoma no se ha demostrado de forma concluyente. El objetivo de nuestro trabajo fue valorar la incidencia de aneuploidía en adenomas colónicos, con y sin signos de malignidad, y estudiar su posible papel en la secuencia adenoma-carcinoma. Material y métodos: el estudio se realizó en una serie de 57 adenomas de intestino grueso, de 10 o más mil

  18. Diseño, desarrollo y validación de un sotfware para la simulación del efecto del campo eléctrico sobre la activación neuronal

    OpenAIRE

    SOLANES GALBIS, CARMEN

    2016-01-01

    [ES] La neuroestimulación medular es una terapia ampliamente utilizada para el tratamiento del dolor neuropático. La neuroestimulación medular consiste en la estimulación eléctrica, a través de un electrodo multipolar, de las grandes fibras Aβ con el fin de disminuir el dolor en los dermatomas correspondientes a las áreas estimuladas. A pesar de su amplia utilización clínica, existe una carencia en el conocimiento sobre el efecto de diferentes factores en la eficiencia de la es...

  19. Abordaje mininamente invasivo del carcinoma de endometrio: laparoscopia convencional frente a laparoscopia robótica

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    García Arreza, Aida

    2016-01-01

    El cáncer de endometrio (CE) es la neoplasia del tracto genital femenino más común en los países desarrollados y la tendencia en los próximos años es que las cifras, tanto de casos nuevos como de mortalidad, sigan aumentando (1, 2). La piedra angular del tratamiento es quirúrgico, es la histerectomía total extrafascial, y debe realizarse linfadenectomía pélvica y paraórtica, según recomendación de la FIGO en lo tumores de tipo no endometrioide, y en los endometrioides de riesgo intermedio...

  20. Studio e valutazione della spermatogenesi e del gleason score in pazienti affetti da carcinoma prostatico

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    DI VICCARO, DOMENICO

    2012-01-01

    Il nostro studio si propone di voler studiare e valutare la qualità del liquido seminale di pazienti affetti da adenocarcinoma prostatico diagnosticato mediante biopsia transperineale ecoguidata.I pazienti che rientravano nei criteri di selezione venivano sottoposti ad intervento chirurgico di prostatectomia radicale retropubica con contestuale linfoadenectomia iliaco-otturatoria bilaterale ove ce ne fosse stata l’indicazione. I pazienti sono stati selezionati presso il nostro ambulatori...

  1. Qualidade de vida em pacientes com lesão medular Calidad de vida en pacientes con lesión medular Quality of life in patients with spinal cord injury

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    Inacia Sátiro Xavier de França; Alexsandro Silva Coura; Francisco Stélio de Sousa; Paulo César de Almeida; Lorita Marlena Freitag Pagliuca

    2013-01-01

    Objetivou-se medir a qualidade de vida de adultos com lesão medular e identificar os domínios que prejudicam a qualidade de vida desses sujeitos. Estudo epidemiológico, realizado no período 2007-2008, em Unidades Básicas de Saúde de Campina Grande/PB. Participaram 47 sujeitos. Utilizou-se questionário contendo variáveis sociodemográficas, etiologia da lesão; instrumento validado para medir qualidade de vida, contendo quatro domínios: Físico, Ambiental, Relações Sociais e Psicológico, com resp...

  2. Nódulos linfóides medulares Bone marrow lymphoid nodules

    Directory of Open Access Journals (Sweden)

    Silvia M. M. Magalhães

    2003-06-01

    Full Text Available A biópsia de medula óssea é parte integrante do estadiamento e seguimento de pacientes com doenças hematológicas. Nódulos linfóides são um achado comum, usualmente observados em associação com doenças inflamatórias crônicas, infecção, hemólise, síndromes mieloproliferativas e doenças auto-imunes. São, em geral, considerados reacionais. Sendo a medula óssea o sítio extranodal mais comumente envolvido nos linfomas foliculares, o diagnóstico diferencial mais importante é a infiltração medular por doença linfoproliferativa. Do ponto de vista prático, os infiltrados linfóides são, em geral, facilmente distinguíveis ao estudo histológico. Agregados reacionais são pequenos, têm bordas delimitadas, são compostos por uma população celular heterogênea e têm localização central. Nódulos malignos infiltram a medula óssea na região paratrabecular e são compostos por células clivadas. A análise imunofenotípica, utilizando um painel de anticorpos monoclonais, é capaz de definir a linhagem celular, subpopulação e estágio de diferenciação da população neoplásica, contribuindo para a confirmação do diagnóstico. Nos casos controversos, a análise molecular da proliferação linfóide pode ser útil. A monoclonalidade pode ser demonstrada pela restrição de cadeias leves ou através do rearranjo do DNA da cadeia pesada das imunoglobulinas. Idealmente, os resultados da análise molecular devem ser interpretados em conjunto com a análise morfológica e imunofenotípica. A morfologia continua sendo o padrão-ouro na avaliação da infiltração medular por linfoma folicular e as análises imunofenotípica e molecular devem ser consideradas complementares.Bone marrow trephine biopsies are an integral part of the diagnosis, staging and follow-up of patients with haematologic disorders. Lymphoid nodules are a common finding, usually reported in association with chronic inflammatory syndromes, infection

  3. período que antecede ao reinício da sexualidade do lesionado vértebro-medular

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    Garrett, Ana; Teixeira, Zélia; Martins, Fernando

    2007-01-01

    Após um evento traumático como uma lesão vértebro-medular, o sujeito organiza determinadas estratégias de forma a encontrar mecanismos de coping que possibilitem diminuir o impacto de diversos momentos com cargas elevadas de stresse. Um deles é o reinício da sua actividade sexual, onde podem estar presentes, entre outros, factores condicionantes como o auto-conceito e a auto-imagem. Este artigo visa demonstrar a adaptabilidade do modelo transaccional de stresse no período que antecede ao r...

  4. Sentimientos de los Familiares ante la Lesión Medular Feelings of the family in face of the spinal cord injury

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    Islene Víctor Barbosa; Zuila Maria de Figueiredo Carvalho

    2011-01-01

    El contexto de la lesión medular conduce a la familia a organizarse y redimensionar y dar otra dirección a su vida, para mejor comprender al individuo y aprender a convivir con las implicaciones de la lesión. Se objetivó conocer los sentimientos que permean la relación de atención de la familia de una persona con lesión medular, a la luz de la teoría de Jean Watson. Estudio cualitativo, realizado de septiembre a octubre de 2007, utilizando entrevista semiestructurada con 7 familiares cuidador...

  5. Estudio de los efectos de la aplicación tópica de imiquimod al 5% en la apoptosis del carcinoma basocelular

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    Vidal Sarró, David

    2003-01-01

    El carcinoma basocelular (CBC) es el tumor maligno más frecuente y en nuestro país su incidencia ha aumentado progresivamente en los últimos años. El tratamiento del CBC se basa en la cirugía, pero ante el envejecimiento de la población ha surgido la necesidad de poder tratar los pacientes con terapias menos agresivas. Imiquimod es un potente inductor de citocinas, principalmente el interferón, con propiedad inmunomoduladora sobre el sistema inmune innato y adquirido. La inmunoterapia con imi...

  6. Estimulação medular espinhal para tratamento da polineuropatia dolorosa refratária induzida por quimioterapia Estimulación medular espinal para tratamiento de la polineuropatía dolorosa refractaria inducida por quimioterapia Spinal cord stimulation in the treatment of refractory painful polineuropathy induced by chemotherapy

    Directory of Open Access Journals (Sweden)

    José Luciano Braun Filho

    2007-10-01

    Full Text Available JUSTIFICATIVAS E OBJETIVOS: Polineuropatia dolorosa pós-quimioterapia tem sido muitas vezes uma condição refratária ao tratamento clínico conservador. O objetivo deste relato de caso foi mostrar o uso da estimulação medular como técnica alternativa aos métodos convencionais para tratar paciente com quadro doloroso de difícil controle. RELATO DO CASO: Paciente de 72 anos, com polineuropatia dolorosa pós-quimioterapia há mais ou menos dez anos, apresentava dor de forte intensidade (escala analógica visual = 10 em membros inferiores, contínua e diária, apesar do uso de várias medicações específicas para dor neuropática. Foi submetido a implante de eletrodo peridural apresentando melhora significativa das dores (escala analógica visual = 3 e diminuição do uso de medicação. CONCLUSÃO: A estimulação da medula espinhal constitui uma opção terapêutica em pacientes com neuropatia periférica refratária ao tratamento médico convencional quando bem indicada e realizada dentro de critérios estabelecidos.JUSTIFICATIVAS Y OBJETIVOS: La polineuropatía dolorosa posquimioterapia ha sido en muchas ocasiones una condición refractaria al tratamiento clínico conservador. El objetivo de este relato de caso fue mostrar el uso de la estimulación medular como técnica alternativa a los métodos convencionales para tratar paciente con cuadro doloroso de difícil control. RELATO DEL CASO: Paciente de 72 años, con polineuropatía dolorosa pos-quimioterapia hace más o menos 10 años, presentaba dolor de fuerte intensidad (escala analógica visual = 10 en miembros inferiores, continua y diaria, a pesar del uso de varias medicaciones específicas para dolor neuropático. Se sometió a implante de electrodo peridural presentando una mejoría significativa de los dolores (escala analógica visual = 3 y una disminución del uso de medicación. CONCLUSIÓN: La estimulación de la médula espinal constituye una opción terapéutica en

  7. Topografia do cone medular da irara (Eira barbara e sua relevância em anestesias epidurais

    Directory of Open Access Journals (Sweden)

    Érika Branco

    2013-06-01

    Full Text Available Encontrada principalmente na América do Sul, a irara é um carnívoro pertencente à família Mustelidae, a qual pouco se tem informações sobre sua morfologia de forma geral. Diante disso, objetivou-se conhecer melhor parte do sistema nervoso desta espécie, mais precisamente a topografia do cone medular, a fim de subsidiar intervenções anestésicas peridurais nesta, uma vez que a clínica de animais selvagens vem crescendo a cada dia. Foram estudados três exemplares machos, adultos, provenientes da área de Mina Bauxita, Paragominas, doados ao Laboratório de Pesquisa Morfológica Animal (LaPMA, Universidade Federal Rural da Amazônia (UFRA, Belém, os quais foram radiografados e dissecados ao nível lombossacral, seguido de exposição do cone medular. Este, por sua vez, situou-se entre L4-L6 possuindo comprimento médio de 4,31cm, o que nos levou a sugerir a região sacrococcígea como ponde ideal para prática de anestesias epidurais nesta espécie.

  8. Carcinoma Verrucoso Oral: Reporte de un Caso Clínico y Revisión de 20 Casos del Instituto de Referencia en Patología Oral (IREPO, Chile Oral Verrucous Carcinoma: A Case Report and Review of 20 Cases of the Oral Pathology Referral Institute (IREPO, Chile

    Directory of Open Access Journals (Sweden)

    D Adorno Farias

    2010-12-01

    Full Text Available El carcinoma verrucoso (CV es una variante rara del carcinoma de células escamosas con características morfológicas y comportamiento específico. El presente estudio relata el caso de una paciente de género femenino, de 68 años de edad, que presenta un carcinoma verrucoso en lengua, indoloro y con 8 meses de evolución. Además, se realizó una breve revisión de casos clínicos del Instituto de Referencia en Patología Oral (IREPO de la Facultad de Odontología de la Universidad de Chile, diagnosticados entre enero de 1984 y octubre de 2010, encontrándose 20 casos, con un promedio de edad de 70 años, localizados con mayor frecuencia en encía inferior y lengua.Verrucous carcinoma (VC, a rare variant of squamous cell carcinoma is an established entity with distinctive morphology and specific clinical behavior. The present study describe a case report of a 68-year-old women who presented a tongue verrucous carcinoma, asymptomatic, that had about 8 months of evolution. A brief review of VC cases diagnosed in Oral Pathology Referral Institute (IREPO, Faculty of Odontology, University of Chile, between 1984 and 2010. It was found 20 cases of verrucous carcinoma with a median age of70-years-old, the most common places were lower gingiva and tongue.

  9. Surgical approach to medullary thyroid cancer Abordagem cirúrgica do carcinoma medular de tiróide

    OpenAIRE

    Catharina Ihre Lundgren; Leigh Delbridg; Diana Learoyd; Bruce Robinson

    2007-01-01

    Medullary thyroid cancer (MTC) compromises 3-5% of all thyroid cancers and arises from parafollicular or calcitonin-producing C cells. It may be sporadic (75% of cases), or may occur as a manifestation of either the hereditary syndrome Multiple Endocrine Neoplasia type 2 (MEN 2A or MEN 2B) (25% of cases), or rarely as an isolated familial syndrome (FMTC). Complete surgical resection comprising in most cases total thyroidectomy with central lymph node dissection at an early stage of the diseas...

  10. The checkpointkinase 2 (CHK2 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN

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    Schipper Jörg

    2010-12-01

    Full Text Available Abstract Background The checkpointkinase 2 (CHK2 is part of the highly conserved ATM-CHK2 signaling pathway, which is activated in response to DNA damage, in particular after double strand breaks which can be caused by carcinogens like smoking. After induction of downstream targets, e.g. the tumor suppressor p53, its activation leads to cell cycle arrest and apoptosis. Recently, the presence of CHK2 germ line mutations, primarily the 1100delC variant, has been reported to be involved in carcinogenesis. The CHK2 1100delC variant results in a truncated protein which is instable and inactive. Carriers of this variant have been shown to have an increased risk to develop breast cancer and probably also other tumors. Our purpose was to investigate the role of CHK2 germ line mutations in patients with squamous cell carcinoma of the head and neck (SCCHN. Materials and Methods We investigated 91 patients suffering from SCCHN including all tumor sites (oropharynx, hypopharynx, larynx for the presence of the germ line mutation 1100delC by direct sequence analysis. Patients were characterized by their tumor localization, tumor stage, age, the presence of additional malignant tumors and predisposing carcinogens (smoking, alcohol abuse. Results None of the patients, independently of the tumor site, age, the abuse of predisposing carcinogens, or the presence of other kinds of tumors, carried the CHK2 1100delC variant. Conclusions The germ line CHK2 1100delC variant does not seem to have a major impact on the development of SCCHN.

  11. Uso de la monitorizacion intraoperatoria del sistema nervioso central y perif??rico en el tratamiento quir??rgico de las afecciones del raquis

    OpenAIRE

    Ca??adas del Castillo, Alfonso

    2003-01-01

    La monitorizaci??n neurofisiol??gica intra-operatoria (MIO) con el empleo combinado de Potenciales Evocados Motores (PEM) y Potenciales Evocados Somatosensoriales (PES) de los pacientes subsidiarios de tratamiento quir??rgico por escoliosis es imprescindible durante los momentos cr??ticos del acto quir??rgico para prevenir y minimizar el riesgo moderado, pero real, de lesiones medulares. Una serie de interrogantes, que es necesario elucidar, se plantean con el objeto de maximinar la utilidad ...

  12. Doença cística medular do rim: relato de um caso diagnosticado por ultra-sonografia e tomografia computadorizada Medullary cystic disease of the kidney: report of a case diagnosed by ultrasonography and computed tomography examinations

    OpenAIRE

    Tarcísio Nunes Carvalho; Cyrillo Rodrigues de Araújo Jr.; Sérgio Roberto Fraguas Filho; Marlos Augusto Bittencourt Costa; Flávia Aparecida de Souza Ribeiro; Kim-Ir-Sen Santos Teixeira

    2003-01-01

    Doença cística medular, nefronofitíase juvenil familiar ou complexo de doença cística medular referem-se a um grupo de doenças similares cuja lesão básica é uma progressiva atrofia tubular renal com esclerose glomerular e formação cística medular. É importante causa de insuficiência renal em pacientes adolescentes. Estudos de imagem têm papel principal no diagnóstico desta enfermidade, com cistos caracteristicamente individualizados na medula renal e junção córtico-medular e tamanho renal nor...

  13. Carcinoma Verrucoso Oral: Reporte de un Caso Clínico y Revisión de 20 Casos del Instituto de Referencia en Patología Oral (IREPO), Chile Oral Verrucous Carcinoma: A Case Report and Review of 20 Cases of the Oral Pathology Referral Institute (IREPO), Chile

    OpenAIRE

    D Adorno Farias; A Maturana Ramírez; M Farias Vergara; ME Franco Martínez; M Iriarte Hernández; R Sáez Salgado; J. Cortés Araya; AV Ortega Pinto

    2010-01-01

    El carcinoma verrucoso (CV) es una variante rara del carcinoma de células escamosas con características morfológicas y comportamiento específico. El presente estudio relata el caso de una paciente de género femenino, de 68 años de edad, que presenta un carcinoma verrucoso en lengua, indoloro y con 8 meses de evolución. Además, se realizó una breve revisión de casos clínicos del Instituto de Referencia en Patología Oral (IREPO) de la Facultad de Odontología de la Universidad de Chile, diagnost...

  14. Diagnostic imaging of lobular carcinoma of the breast. Mammographic, US and MR findings; La diagnostica per immagini del carcinoma lobulare della mammella. Aspetti mammografici, ecografici e con Risonanza Magnetica

    Energy Technology Data Exchange (ETDEWEB)

    Bazzocchi, M.; Facecchia, I.; Zuiani, C.; Smania, S. [Udine Univ., Udine (Italy). Ist. di Radiologia; Puglisi, F. [Udine Univ., Udine (Italy). Reparto di Oncologia; Di Loreto, C. [Udine Univ., Udine (Italy). Ist. di Anatomia Patologica

    2000-12-01

    . Invasive lobular carcinoma of the breast is often very difficult to diagnose. Thus, it is suggested the use of integrated diagnostic imaging with mammography, US and, in some cases, MRI for earlier diagnosis and to identify further tumor localizations. [Italian] In questo articolo si valutano le piu' frequenti caratteristiche mammografiche ed ecografiche del carcinoma lobuare ed e' studiato quale possa essere l' apporto della RM nella migliore definizione dell'estensione di questo tipo di neoplasia soprattutto nel definire l'eventuale multifocalita' e/o multicentricita'. 39 pazienti affette da 46 neoplasie lobulari su 421 neoplasie mammarie sono stati esaminate. In 39 casi si e' fatto ricorso alla agobiopsia percutanea microistologica con ago da 14G (36/39 eseguite sotto guida ecografica, 3/39 sotto guida mammografica), in 2 direttamente alla biopsia chirurgica. Per 5 lesioni la diagnosi e' avvenuta solo dopo mastectomia. Tutte le pazienti sono state sottoposte a mammografia e a ecografia (10-13 MHz); 8 pazienti sono state sottoposte anche a RM. Ventotto su 46 lesioni (60,9%) erano palpabili. Con l'agobiopsia percutanea microistologica sono state diagnosticate correttamente 38/39 lesioni (97,4%). Nella mammografia l'aspetto piu' frequente e' stato quello di opacita' nodulare senza microcalcificazioni (34,8%), seguito da quella di opacita' spiculata senza microcalcificazioni (30,4%). In 1 caso erano presenti microcalcificazioni (2,2%). Nel 15,2% dei casi non c'era riscontro mammografico di lesione; 2 di tali lesioni (28,6%) sono state identificate solo grazie all'ecografia. Nell'ecografia l'aspetto piu' frequente e' stato quello di lesione ipocogena (43,5%), seguito dall'attenuazione posteriore del fascio ultrasonoro. Nel 15,2% dei casi non vi erano segni ecografici. Con la RM sono state individuate 13 lesioni. In 10 casi l'accentuazione e' stata superiore

  15. Carcinoma vulvar

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    Yamit Peñas Zayas

    2015-11-01

    Full Text Available El carcinoma de la vulva tiene una incidencia de aproximadamente un 3-5% dentro de todas las enfermedades ginecológicas malignas. El 90% de los tumores malignos de la vulva está constituido por carcinoma epidermoide, el resto son adenocarcinomas, carcinomas de células basales y melanomas. Se realiza la presentación de un caso de una paciente femenina de 25 años de edad con antecedentes  de Diabetes Mellitus tipo II y trombopatia, que ingresa en el servicio de ginecología con un cuadro cutáneo polimorfo, localizado en labios mayores y menores, dado por lesiones eritematoerosivas y vegetante, sospechándose clínicamente el diagnóstico  de un carcinoma epidermoide, corroborándose el mismo histológicamente al realizarse biopsia de piel. Se indicó tratamiento con quimioterapia. Por la edad de la paciente y ser menos frecuente en mucosa que en la piel,  motivo la presentación del caso.

  16. Epidemiología retrospectiva y análisis de las características múltiples del carcinoma espinocelular de la mucosa bucal con estudio histopatológico de biopsias

    OpenAIRE

    Baudo, Judith Ethel

    2000-01-01

    La Organización Mundial de la Salud ha venido estableciendo parámetros de estudio histológico y clasificaciones de las enfermedades precancerosas y carcinoma oral. Ha efectuado distintas revisiones con el fin de implicar los conceptos para los patólogos de todas las naciones. El objetivo general de este trabajo fue actualizar los aspectos epidemiológicos, clínicos, condicionantes, etiológicos, y de diagnóstico, pronóstico y tratamiento del carcinoma a células escamosas de la mucosa bucal. ...

  17. Estudio in vitro de los efectos del resveratrol y la irradiación sobre la viabilidad, apoptosis, migración y el ciclo celular en el carcinoma oral de células escamosas

    OpenAIRE

    Navarro Atiénzar, Antonio

    2012-01-01

    INTRODUCCIÓN: El carcinoma oral de células escamosas, histológicamente, es el tumor más común observado en la cavidad oral. El resveratrol es un producto antioxidante natural polifenólico que, recientemente, ha sido declarado un agente antitumoral y quimiopreventivo. OBJETIVO: Estudio in vitro para evaluar el efecto del resveratrol combinado con la irradiación, sobre el carcinoma oral humano de células escamosas. MATERIAL Y MÉTODOS: El resveratrol ha sido administrado en dosis de 5, ...

  18. Diagnóstico diferencial das lesões inflamatórias e infecciosas do cone medular utilizando a ressonância magnética

    OpenAIRE

    Gustavo Balthazar da Silveira Carvalho; Gabriel Barbosa Sandim; Luis Antônio Tobaru Tibana; Franklin Freitas Tertulino; Marcos Hideki Idagawa; Nitamar Abdala

    2013-01-01

    O cone medular é frequentemente acometido por lesões de etiologia inflamatória e infecciosa, muitas vezes de difícil diferenciação devido a história clínica e exame físico semelhantes entre as diversas entidades. A ressonância magnética apresenta alta sensibilidade na detecção de lesões no cone medular e tem importante papel no diagnóstico e controle evolutivo. Este ensaio iconográfico com casos selecionados dos arquivos do nosso serviço tem como objetivo demonstrar achados de imagem que poss...

  19. Una revisión a la teoría general del costo

    OpenAIRE

    Amaro Yardin

    2002-01-01

    El trabajo tiene como objetivo definir qué debe entenderse por una Teoría General del Costo y, en consecuencia, cuál debe ser su contenido. Se comienza por emitir algunas consideraciones sobre el concepto de "Teoría" y, complementariamente, el de "Teoría General del Costo". Se exponen consideraciones sobre la naturaleza y los objetivos de las distintas manifestaciones de la técnica contable, concretadas en la Contabilidad Patrimonial y la Contabilidad de Gestión. La parte medular del trabajo ...

  20. Perspectivas da aplicação das conotoxinas bloqueadoras de canais para cálcio dependentes de voltagem no trauma medular

    Directory of Open Access Journals (Sweden)

    Karen Maciel de Oliveira

    2014-03-01

    Full Text Available O bloqueio dos canais para cálcio dependentes de voltagem é uma estratégia importante no tratamento do trauma medular, pois previne o influxo exacerbado do cálcio que participa ativamente em processos neurodegenerativos agudos, resultando em neuroproteção com melhora das funções neurológica. Dentre esses bloqueadores, as toxinas de caramujos marinhos são peptídeos com adequada estabilidade estrutural, estudadas pelas ações específicas em canais iônicos e receptores que interferem diretamente na liberação de neurotransmissores e na neuromodulação dos neurônios motores e sensitivos da medula espinal. Elas já são utilizadas no tratamento de desordens neurológicas e mostram-se promissoras no desenvolvimento de novas terapias para o trauma medular. Portanto, objetivou-se discorrer sobre a fisiopatologia do trauma medular e a possível utilização terapêutica das toxinas de caramujo marinho, atuantes nos principais canais para cálcio dependentes de voltagem.

  1. Carcinoma epidermoide cutáneo: relación con los trastornos respiratorios del sueño y definición de la variante alto riesgo

    OpenAIRE

    Díaz Corpas, Tania

    2015-01-01

    Introducción: Recientes publicaciones han mostrado que la hipoxia intermitente similar a la que encontramos en el síndrome de apnea e hipopnea del sueño (SAHS) parece estar implicada en el desarrollo, progresión y crecimiento de tumores en modelos animales, a través de la sobreproducción de factores de crecimiento (entre ellos el factor de crecimiento vascular endotelial o VEGF) y la interacción con la vía supresora del gen p53. EL carcinoma epidermoide cutáneo (CEC) es un tumor procede...

  2. Topografia do cone medular do sauim (Saguinus midas Topography of the medullary cone in sauim (Saguinus midas

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    Danielli Martinelli Martins

    2013-06-01

    Full Text Available Primata endêmico do Brasil, especificamente da floresta Amazônica, o Sauim alimentam-se de pequenos vertebrados, invertebrados, exudatos, flores, néctar, folhas e fungos, cuja morfologia é pouco conhecida. Assim, objetivou-se estabelecer parâmetros morfométricos e topográficos do cone medular dessa espécie, que sirvam de base para a prática das anestesias epidurais. Para tanto, foram avaliados quatro exemplares, provenientes da Universidade Federal Rural da Amazônia (UFRA. O Saguinus midas apresentou sete vértebras lombares e três vértebras sacrais. Após a dissecação do cone medular, registrou-se os aspectos anatômicos de interesse, enfatizando seu início (base e seu término (ápice, que, após mensuração, revelou base em nível de L4 e ápice em S2, com comprimento médio de 5,38cm, o que leva a sugerir a região lombosacral como sendo a mais adequada para o desenvolvimento da prática de anestesias epidurais.Primate endemic to Brazil, specifically in the Amazon rainforest, the Sauim feed on small vertebrates, invertebrates, exudates, flowers, nectar, leaves and fungi whose morphology is poorly known. Thus, the objective was to establish morphometric parameters and topographical conus of this species, as a basis for the practice of epidural anesthesia. For this purpose, four samples were evaluated, from the Universidade Federal Rural da Amazônia (UFRA. The Saguinus midas had seven lumbar vertebrae and three sacral vertebrae. After dissection of the conus, we recorded the anatomy of interest, emphasizing its beginning (base and its end (apex, revealed that after measuring the level of base peak in L4 and S2, with an average length of 5.38cm, which leads us to suggest the lumbosacral region as the most suitable for the development of the practice of epidural anesthesia.

  3. "Gato encerrado" o "confidencialidad comercial": el problema del secreto en la venta de un reactor nuclear "Gato encerrado" or "confidencialidad comercial": a secret problem regards the sale of a nuclear reactor

    OpenAIRE

    Ana Spivak L'Hoste

    2006-01-01

    En este artículo se propone abordar uno de los aspectos medulares de la disputa pública que surge a partir de la venta de un reactor nuclear diseñado por una empresa argentina a Australia en el año 2000. Se trata del problema del secreto que atraviesa, para quienes están involucrados en la misma y desde dos perspectivas claramente diferentes, la operación comercial. A través del análisis de las categorías locales que hacen a la configuración del problema del secreto, gato encerrado y secreto ...

  4. Manejo quirúrgico conservador del epitelioma basocelular infiltrante del canto interno Conservative surgical management of the basal cell carcinoma infiltrating inner canthus

    OpenAIRE

    A.J. Abulafia; C.N. Saladino; V. Viñas; M.A. Viñal

    2011-01-01

    El epitelioma basocelular es el tumor maligno más frecuente de la piel. Su histogénesis se relaciona con la exposición actínica, por lo que su mayor incidencia se da a nivel de la cara. Normalmente la dermis actúa como factor de resistencia a la invasión tisular del tumor, situación que no se da en ciertas zonas en las que se observa un crecimiento con mayor invasión en profundidad. De estas zonas reviste importancia por su cercanía a órganos vitales el canto interno ocular, sobre todo en les...

  5. Manejo quirúrgico conservador del epitelioma basocelular infiltrante del canto interno Conservative surgical management of the basal cell carcinoma infiltrating inner canthus

    Directory of Open Access Journals (Sweden)

    A.J. Abulafia

    2011-03-01

    Full Text Available El epitelioma basocelular es el tumor maligno más frecuente de la piel. Su histogénesis se relaciona con la exposición actínica, por lo que su mayor incidencia se da a nivel de la cara. Normalmente la dermis actúa como factor de resistencia a la invasión tisular del tumor, situación que no se da en ciertas zonas en las que se observa un crecimiento con mayor invasión en profundidad. De estas zonas reviste importancia por su cercanía a órganos vitales el canto interno ocular, sobre todo en lesiones con extensa invasión local, por la disyuntiva del compromiso ocular y la decisión de su conservación o no. Comentamos nuestra experiencia en el tratamiento de lesiones infiltrativas de canto interno, así como la secuencia de estudio y las opciones terapéuticas.Basal cell epithelioma is the most common malignant tumor affecting the skin. It is mainly located in sun-exposed areas of the body surface due to solar actinic radiation. The facial skin is the most exposed, and the one with the highest incidence of these tumors. The dermis normally acts as a barrier against deepening, a fact which does not occur in certain areas. Among these critical sites the inner canthus region has a critical interest due to its proximity to vital organs with doubts about eye involvement and its preservation. We comment our experience in the management of infiltrative tumors of the inner canthus, diagnostic steps and therapeutical alternatives.

  6. Seguridad de la resonancia mágnetica en pacientes con neuroestimuladores medulares: Nuestra experiencia Safety of magnetic resonance in patients with implanted spinal cord neurostimulators: Our experience

    Directory of Open Access Journals (Sweden)

    C. Mesa-del-Castillo

    2006-10-01

    Full Text Available Introducción: En la ultima década la resonancia magnética (RM ha sido introducida como una herramienta rutinaria de diagnóstico clínico por imagen, siendo considerada como una prueba no invasiva y segura. Sin embargo se ha contraindicado su utilización en pacientes que poseen dispositivos electrónicos implantados, entre ellos neurostimuladores medulares y corticales. A diferencia del avance de la tecnología en neuroesti-mulación y su aplicación clínica, hay pocos estudios que avalen la seguridad de la RM en pacientes con neuroestimuladores implantados. Nuestra hipótesis es que la RM es un método diagnóstico seguro en los pacientes con neuroestimuladores implantados. Nuestro trabajo tiene como finalidad aportar más pruebas objetivas acerca de esta cuestión. Material y Métodos: Serie de 8 pacientes con neuroestimuladores implantados (ITRELL III modelo 7425, Medtronic sometidos a 9 estudios de RM (1,5 T General Electric Sigma Excite durante el 2005, siguiendo el protocolo de Liem van Dongen en los que se vigiló la aparición de efectos adversos relacionados, durante e inmediatamente después del estudio de imagen. Resultados: Durante los estudios de RM no se produjeron incidencias, ni efectos adversos, en ninguno de los casos, tanto en los que el estudio se realizó en zonas alejadas del implante del neuroestimulador, como en los que se realizó en la misma zona anatómica. Una vez concluido el estudio de RM no se objetivó ninguna referencia de los pacientes a sensaciones relacionadas con el calentamiento o interacción electromagnética de la RM con su neuroestimulador. Tampoco se produjo ningún fallo en la reprogramación de los neuroestimuladores, excepto en un caso en el que fue imposible reprogramar el neuroestimulador una vez concluido el estudio de RM. Conclusiones: Todo parece indicar que en la mayoría de los casos la RM puede ser aplicada de forma segura en pacientes con sistemas de neruroestimulación implantados

  7. La Seguridad ciudadana como función del Estado

    OpenAIRE

    Ridaura Martínez, María Josefa

    2014-01-01

    Este trabajo se centra en uno de los temas medulares de la organización del Estado como es la garantía de la seguridad, y tiene como objeto reivindicar, al calor la reciente sacudida legislativa en materia, la función de la Seguridad ciudadana como una función pública a desarrollar por las Fuerzas y Cuerpos de Seguridad; en tanto que exigencia constitucional, presupuesto de la salvaguarda de los derechos fundamentales y de las libertades públicas.

  8. Alterações vesicais na lesão medular experimental em ratos Urinary bladder changes in experimental spinal cord injury

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    Fernando Meyer

    2003-06-01

    Full Text Available O trauma raquemedular é uma das lesões traumáticas com maior impacto sobre a sociedade, o que faz com que enormes investimentos sejam feitos em estudos visando sua cura. Para a realização de pesquisas sobre lesão medular, é necessário que se utilize um modelo reprodutível desta lesão. A padronização de um sistema de lesão medular experimental provoca alterações não só no sistema nervoso mas também sistêmicas. OBJETIVO: O presente estudo visa avaliar as alterações vesicais na fase aguda da lesão medular experimental. MÉTODOS Foram utilizados 34 ratos Wistar machos divididos em grupo controle (A e grupo experimento (B. Enquanto os animais do grupo B foram submetidos à laminectomia no nível T9-T10 seguida de lesão medular, os do grupo A (n=4 foram submetidos somente à laminectomia. Os animais do grupo B foram dividos em 6 grupos distintos (n=5 e foram submetidos à eutanásia após 2, 4, 8, 24, 48 horas e 4 dias. RESULTADOS: Verificou-se redução da camada urotelial em todos animais do grupo B, presença de células inflamatórias e congestão vascular principalmente após 8 horas, entre outros achados. CONCLUSÃO: As alterações histológicas na fase aguda da lesão medular evidenciaram importante comprometimento vesical, sendo essa uma alteração sistêmica de relevância em lesados medulares.Spinal cord trauma is one of the lesions with highest socioeconomical impact. To develop research on spinal cord field it is mandatory to use a reproductible model for inducing lesions. Standardized spinal cord injury (SCI promotes changes not only in the nervous system but also systemic changes. PURPOSE: The aim of this study was to evaluate urinary bladder changes during the acute phase of experimental spinal cord injury. METHODS: Thirty four Wistar male rats were allocated in 2 groups: controll (A and experiment (B. While animals from group B underwent laminectomy at T9-T10 level followed by SCI, group A underwent only

  9. En defensa del financiamiento de los medios públicos de comunicación

    OpenAIRE

    Javier Esteinoú

    2005-01-01

    Dentro del escenario histórico de la transición pacífica a la democracia cobra una importancia medular el rescatar la misión histórica de los medios públicos de comunicación colectivos, para reequilibrar la desproporción estructural que en el terreno comunicativo, cultural, y espiritual ha vivido la sociedad mexicana en las últimas décadas, con la actuación desproporcionada del modelo de comunicación-mercado; y transformar el nuevo espacio público mediático en una moderna zona de reconstrucci...

  10. Análisis de la expresión génica global en estados iniciales del carcinoma no microcítico de pulmón: identificación de un predictor de recidiva asociado con las células B del sistema inmune

    OpenAIRE

    Hernández Prieto, Susana

    2014-01-01

    ANTECEDENTES El cáncer de pulmón es la primera causa de muerte por cáncer con una tasa anual de más de 1.1 millones de personas en todo el mundo. Aproximadamente el 80% de los casos diagnosticados se clasifican como carcinoma no microcítico de pulmón (CNMP) y el 20% restante corresponden a carcinoma microcítico de pulmón (CMP). La tasa de supervivencia a cinco años entre los pacientes diagnosticados de cáncer de pulmón es sólo del 15%. El sistema de estadiaje TNM basado en el tamaño del tumo...

  11. Úlceras por presión en personas con lesión medular: conocimiento de familiares y cuidadores

    OpenAIRE

    ZUILA MARIA DE FIGUEIREDO; JUAN JOSÉ TIRADO; FRANCISCO VICENTE MULET; ANTONIO JOSÉ NÚÑEZ; LUCIENE MIRANDA DE ANDRADE; MAIRA DI CIERO MIRANDA; MARIA GORETTI SOARES MONTEIRO

    2010-01-01

    Objetivo: evaluar el conocimiento sobre los factores de riesgo y prevención de úlceras por presión, desde la perspectiva de los familiares y cuidadores de personas con lesión medular en el domicilio. Método: estudio descriptivo transversal, cuantitativo. La muestra fue de 50 personas. Los datos se recogieron por medio de un cuestionario en los meses de agosto a diciembre de 2008. El análisis estadístico se realizó con el programa SPSS Windows, versión 13.0. Resultados: se constató que la fami...

  12. Perspectivas da aplicação das conotoxinas bloqueadoras de canais para cálcio dependentes de voltagem no trauma medular

    OpenAIRE

    Karen Maciel de Oliveira; Mário Sérgio Lima Lavor; Fabíola Bono Fukushima; Fátima Caetano Caldeira; Eliane Gonçalves de Melo

    2014-01-01

    O bloqueio dos canais para cálcio dependentes de voltagem é uma estratégia importante no tratamento do trauma medular, pois previne o influxo exacerbado do cálcio que participa ativamente em processos neurodegenerativos agudos, resultando em neuroproteção com melhora das funções neurológica. Dentre esses bloqueadores, as toxinas de caramujos marinhos são peptídeos com adequada estabilidade estrutural, estudadas pelas ações específicas em canais iônicos e receptores que interferem diretamente ...

  13. La lesión medular como factor de riesgo dedisfunción sexual en el varón

    OpenAIRE

    López García-Moreno, Antonio-Miguel

    2013-01-01

    [ES]El objetivo principal de esta tesis fue la comprobación de la existencia de diferencias significativas en el funcionamiento de las vías neurológicas que intervienen en el desarrollo de la función sexual entre pacientes con lesión medular y disfunción sexual y pacientes con disfunción sexual de etiología no neurógena. Como objetivos secundarios se pretende la comprobación de la existencia de diferencias significativas entre ambos grupos de pacientes respecto a la vascularización pene...

  14. Carcinoma verrugoso

    Directory of Open Access Journals (Sweden)

    Esteban Quesada Jiménez

    2004-09-01

    Full Text Available Se presenta el caso de un paciente masculino de 76 años, vecino de Turrialba, agricultor, que consultó por una lesión de 3 años de evolución, localizada en la palma de la mano derecha a nivel palmar y compromiso de los dedos de la misma mano, caracterizada como una neoformación exofítica verrugosa de 5 por 11 cm. aproximadamente, con material caseoso entre sus crestas. La lesión ha estado creciendo de forma acelerada en los últimos 3 meses, causándole dolor y que le imposibilita ellaborar. Se le realizaron exámenes y se descartaron varias causas infecciosas, y concluyendo luego de varias biopsias con el diagnóstico de un carcinoma verrugoso. El paciente fue tratado mediante una amputación parcial de la mano. Este tumor es una variante del carcinoma epidermoide y presentamos su clasificación, patogénesis, histopatología, manifestaciones clínicas más frecuentes y diagnóstico diferencial.

  15. Diagnóstico diferencial das lesões inflamatórias e infecciosas do cone medular utilizando a ressonância magnética

    Directory of Open Access Journals (Sweden)

    Gustavo Balthazar da Silveira Carvalho

    2013-02-01

    Full Text Available O cone medular é frequentemente acometido por lesões de etiologia inflamatória e infecciosa, muitas vezes de difícil diferenciação devido a história clínica e exame físico semelhantes entre as diversas entidades. A ressonância magnética apresenta alta sensibilidade na detecção de lesões no cone medular e tem importante papel no diagnóstico e controle evolutivo. Este ensaio iconográfico com casos selecionados dos arquivos do nosso serviço tem como objetivo demonstrar achados de imagem que possam auxiliar no diagnóstico de uma etiologia específica entre as doenças inflamatórias e infecciosas e na diferenciação com doenças de outras etiologias como neoplasias e causas vasculares. Características como padrão de realce, presença de cistos, edema, além do acometimento de outras regiões do sistema nervoso central são importantes para esta diferenciação, podendo definir uma etiologia específica quando associadas ao quadro clínico e laboratorial.

  16. Invasive medullary thymoma associated with myasthenia gravis: an unusual case Miastenia gravis em um paciente com timoma medular invasivo: relato de caso

    Directory of Open Access Journals (Sweden)

    JORGE S. REIS FILHO

    2000-12-01

    Full Text Available Thymomas are tumors characterized by a remarkable morphological heterogeneity and variable clinical behavior. This tumor has unique clinical associations, most notably with hematological abnormalities and myasthenia gravis. According with the Müller-Hermelink criteria, there are significant differences between the histological types of thymomas and the association with myasthenia gravis. Among the different histological types, medullary thymoma is the least frequent variant associated with this autoimmune disease. In this report we describe a case of medullary thymoma presenting in a 71-year- old woman with a myasthenic syndrome.Os timomas são tumores caracterizados por grande heterogeneidade morfológica e comportamento clínico variável. Este tumor apresenta associações clínicas singulares, principalmente com doenças hematológicas e com a miastenia gravis. De acordo com a classificação de Müller-Hermelink, existem diferenças significativas entre as variedades histológicas dos timomas e sua associação com a miastenia gravis. Entre os diferentes tipos histológicos, o timoma medular é a variante menos frequentemente associada com esta doença autoimune. Neste relato, nós descrevemos caso de timoma medular em uma paciente de 71 anos de idade com síndrome miastênica.

  17. Resultados de la aplicación de un protocolo prequirúrgico de estadificaclón de maxima certeza en el tratamiento del carcinoma broncogénico

    OpenAIRE

    Obiols Fornell, Carme

    2014-01-01

    [spa] El carcinoma broncogénico (CB) representa la primera causa de mortalidad por cáncer en ambos sexos en los países desarrollados. La evaluación prequirúrgica del mediastino es esencial para definir el pronóstico y guiar el tratamiento de estos pacientes. Las guías para la estadificación ganglionar mediastínica preoperatoria de la European Society of Thoracic Surgeons (ESTS) recomiendan una exploración con certificación cito-histológica, ya sea con técnicas endoscópicas de punción guiada ...

  18. Seric thyroglobulin behavior in thyroid carcinoma patients treated with 131I

    International Nuclear Information System (INIS)

    The thyroid carcinomas, mainly the differentiated ones, for involving originally young patients and for showing relatively benign course, require a long term follow-up. So, every new available method that may be useful for the follow-up of these patients soon becomes very important. The advent of radioimmunoassay made the determination of thyroglobulin seric levels possible and this practice has been incorporated into medical routine in the past few years. The analysis of the results permit to conclude that the administration of 131I therapeutic dose to differentiated and medular thyroid carcinoma patients is followed by imediate and transitory rise in circulating thyroglobulin levels. It denotes immediate effect of the 131I that can be observed in a short period of time independently of L-T3 administration and endogen TSH levels. After this period the thyroglobulin is at least in a partial way, TSH-dependent. (author)

  19. Dor no ombro em pacientes com lesão medular Shoulder pain in spinal cord injury

    Directory of Open Access Journals (Sweden)

    Priscila Elisa Siqueira Gianini

    2006-01-01

    Full Text Available A lesão medular (LM é uma das formas mais graves dentro das síndromes incapacitantes. O paciente com LM sobrecarrega excessivamente os membros superiores, especialmente os ombros, utilizando-os mais freqüentemente e em maior variabilidade de atividades que uma pessoa sem LM. Além disso, a busca da melhoria da qualidade de vida nos últimos anos, levou um número crescente de portadores de LM a procurar a prática de atividade física. Muitos pacientes com LM utilizam cadeira de rodas para locomoção funcional e realização de esportes. Porém, esta demanda funcional na articulação do ombro pode levar a presença de quadro álgico importante interferindo nas atividades de vida diária desses pacientes. Com os adventos da tecnologia e cuidados com a saúde, a expectativa de vida dos pacientes com LM tem aumentado. Desde então, questões relacionadas à qualidade de vida e doenças associadas com o envelhecimento são de grande importância para essa população. Este estudo busca um melhor entendimento da dor no ombro em pacientes com LM através de revisão da literatura.The spinal cord injury (SCI is one of the most severe forms of disabling syndromes. Patients with SCI usually apply an excessive overload on the upper limbs, especially the shoulders, using them more frequently and in a greater range of activities when compared to healthy subjects. Moreover, the search for the improvement of the quality of life in the last years has led an increasingly number of SCI patients to practice physical activities. Many SCI patients use wheelchairs for functional locomotion and sports practice. However, this functional demand on shoulder's joint may lead to a painful picture, interfering on these patient's daily activities. With the improvements on technology and healthcare life expectancy for SCI patients has been increased. Since then, issues regarding quality of life and age-related diseases are very important for this population. The

  20. La mutacion H63D del gen HFE se asocia con un riesgo aumentado de carcinoma hepatocelular The H63D mutation of the HFE gene is related to the risk of hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    P. Ropero

    2007-07-01

    Full Text Available Objetivo: comprobar si las mutaciones del gen HFE, que pueden inducir sobrecarga hepática de hierro, guardan relación con el riesgo de desarrollar carcinoma hepatocelular (CHC en sujetos predispuestos a sufrir este tumor. Material y métodos: se han incluido 196 pacientes (161 varones diagnosticados de CHC. Ninguno estaba diagnosticado de hemocromatosis. El grupo control estaba constituido por 181 sujetos sanos. Todos los sujetos eran españoles de raza blanca.Las mutaciones C282Y y H63D del gen HFE se identificaron mediante reacción en cadena de polimerasa (PCR sobre ADN genómico leucocitario utilizando enzimas de restricción específicas. Resultados (casos/controles: 1. Distribución genotípica: a mutación C282Y: 1/0 homocigotos, 12/23 heterocigotos, 183/158 normales (p = 0,07, n.s.; y b mutación H63D: 9/5 homocigotos, 85/52 heterocigotos, 102/124 normales (odds ratio 2,00, IC95% 1,29-3,12, p = 0,002. Cuatro casos y seis controles eran heterocigotos compuestos. 2. Frecuencias alélicas: a mutación C282Y: normales 378/339, mutados 14/23 (p = 0,11, n.s.; b mutación H63D: normales 289/300; mutados 103/62 (odds ratio 1,72, IC95% 1,19-2,50, p = 0,004. No se observaron diferencias en relación con el sexo, la edad o la etiología (VHC, VHB, etílica o mixta de la hepatopatía previa. Conclusiones: la mutación C282Y no guarda relación con el riesgo de desarrollar CHC en sujetos sin hemocromatosis conocida. La posesión de la mutación H63D se asocia con un riesgo aumentado de desarrollar CHC independientemente de la etiología de la hepatopatía crónica subyacente.Aim: to disclose whether mutations in the HFE gene inducing liver iron overload are related to the risk of hepatocellular carcinoma (HCC in otherwise predisposed patients. Patients and methods: one hundred and ninety-six patients (161 males diagnosed with HCC and 181 healthy controls were included in the study. All subjects were white Spaniards. C282Y and H63D mutations in the

  1. Doença cística medular do rim: relato de um caso diagnosticado por ultra-sonografia e tomografia computadorizada Medullary cystic disease of the kidney: report of a case diagnosed by ultrasonography and computed tomography examinations

    Directory of Open Access Journals (Sweden)

    Tarcísio Nunes Carvalho

    2003-12-01

    Full Text Available Doença cística medular, nefronofitíase juvenil familiar ou complexo de doença cística medular referem-se a um grupo de doenças similares cuja lesão básica é uma progressiva atrofia tubular renal com esclerose glomerular e formação cística medular. É importante causa de insuficiência renal em pacientes adolescentes. Estudos de imagem têm papel principal no diagnóstico desta enfermidade, com cistos caracteristicamente individualizados na medula renal e junção córtico-medular e tamanho renal normal ou reduzido. Neste artigo demonstramos os achados de imagem da doença cística medular renal em uma adolescente com quadro clínico característico, por meio de ultra-sonografia e tomografia computadorizada.The terms medullary cystic disease, juvenile nephronophthisis or medullary cystic disease complex refer to a group of similar diseases in which the basic pathological abnormality is progressive renal tubular atrophy with secondary glomerular sclerosis and medullary cystic formation. Medullary cystic disease is an important cause of renal failure in adolescent patients. Imaging methods play a primary role in the diagnosis of these diseases. Cysts are characteristically seen in the renal medulla and corticomedullary junction whereas kidneys may be of normal to small size. In this article we present the ultrasonography and computed tomography findings of a female adolescent patient with characteristic clinical picture of medullary cystic disease.

  2. Carcinoma de tumor primario desconocido—Versión para profesionales de salud

    Science.gov (United States)

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del carcinoma de tumor primario desconocido, así como referencias a estudios clínicos y otros temas relacionados.

  3. Avaliação do tratamento cirúrgico nos pacientes com metástase vertebral secundária ao carcinoma de mama Evaluación del tratamiento quirúrgico en pacientes con metástasis vertebrales secundarias a carcinoma de mama Evaluation of surgical treatment of patients with vertebral metastasis secondary to breast carcinoma

    Directory of Open Access Journals (Sweden)

    Alex Veneziano Oliveira Junior

    2012-09-01

    Full Text Available OBJETIVO: Avaliar os resultados cirúrgicos dos pacientes com metástase vertebral secundária ao carcinoma de mama. MÉTODOS: Vinte e duas pacientes operadas com doença metastática vertebral secundária ao carcinoma de mama foram avaliadas no pré-operatório, pós-operatório imediato e depois de 1 mês e 6 meses do procedimento cirúrgico, usando a escala numérica da dor e o índice de incapacidade de Oswestry (ODI. RESULTADOS: As medidas para dor produziram valor de p de 0,0001 para a diferença entre o pré-operatório e o pós-operatório imediato, 0,0005 entre o pós-operatório imediato e 1 mês de pós-operatório, e 0,0908 entre 1 mês de pós-operatório e 6 meses de pós-operatório, portanto, encontram-se evidências de diferenças entre o pré-operatório e o pós-operatório imediato, assim como entre o pós-operatório imediato e após o 1º mês, mas não há tal evidência entre o 1º e o 6º mês de pós-operatório. Quanto ao ODI, a diferença foi significativa em todos os períodos. CONCLUSÃO: A cirurgia melhora a dor e diminui a incapacidade dos pacientes com doença metastática secundária ao carcinoma de mama.OBJETIVO: Evaluar los resultados quirúrgicos de los pacientes con metástasis vertebrales secundarias a carcinoma de mama. MÉTODOS: Veintidós pacientes operados con enfermedad metastásica espinal secundaria a carcinoma de mama fueron evaluadas antes de la cirugía, inmediatamente después de la operación y después de 1 mes y 6 meses de la cirugía, mediante la escala numérica del dolor y el índice de discapacidad de Oswestry. RESULTADOS: Las medidas para el dolor produjeron un valor de "p" de 0,0001 para la diferencia entre el pre y postoperatorio, 0,0005 entre el postoperatorio inmediato y un mes después de la operación, y 0,0908 entre 1 mes después de la cirugía y el postoperatorio de 6 meses, por lo tanto, son la evidencia de las diferencias entre el pre y postoperatorio, así como entre el

  4. Disrafias vertebro-medulares caudais: formas intra-sacras Caudal spinal cord disraphism: intra-sacral forms. Report of 4 cases

    Directory of Open Access Journals (Sweden)

    Pedro M. Sampaio

    1975-03-01

    Full Text Available Os autores abordam a gênese das disrafias vértebro-medulares caudais, e se atêm aos divertículos meníngeos intra-sacros. Encontraram na literatura pertinente, descrição de 24 casos e acrescentaram 4 de sua experiência. A incontinencia urinaria foi sintoma proeminente e o resultado cirúrgico compensador. O diagnóstico foi firmado por mielografia.The mean theories of the sacral spinal dysraphisms are reviwed and 4 cases of "meningeal intrasacral diverticulum" are reported. The authors prefer this term to the more common "intrasacral occult meningocele". The proeminent symptom in their cases was late vesical incontinence, which disappeared after surgery. In the pertinent litterature 24 similar cases were described till now.

  5. Transplante de células-tronco derivadas do tecido adiposo em ratos submetidos à lesão medular compressiva, com e sem tratamento com corticoide

    OpenAIRE

    Villanova Junior, José Ademar

    2013-01-01

    Resumo: O trauma constitui uma causa relevante de mortalidade no mundo, atinge principalmente a população jovem, economicamente ativa, e leva muitas vezes a sequelas incapacitantes. O tratamento convencional após o trauma é a utilização de corticoide, que nem sempre apresenta resultado satisfatório. As células-tronco têm sido utilizadas em vários ensaios pré-clínicos de lesão medular e são consideradas uma alternativa promissora. A interrupção da fase inflamatória e a utilização da terapia ce...

  6. Reproducibilidad del diagnóstico histopatológico de lesiones precursoras del carcinoma gástrico en tres países latinoamericanos Reproducibility of histopathologic diagnosis of precursor lesions of gastric carcinoma in three Latin American countries

    Directory of Open Access Journals (Sweden)

    Elena Kasamatsu

    2010-10-01

    Full Text Available Objetivo. Evaluar la concordancia en el diagnóstico de lesiones precursoras del carcinoma gástrico de tipo intestinal entre observadores con diferente experiencia. Material y métodos. Se estudiaron 1 056 casos de biopsias gástricas: 341 de Colombia, 382 de México y 333 de Paraguay. En el diagnóstico de cada caso participaron patólogos sin experiencia en patología gastrointestinal (A, patólogos con experiencia en patología gastrointestinal (B y expertos que trabajan en un centro de referencia internacional (C. Resultados. La concordancia (k entre patólogos inexpertos y expertos fue pobre en el diagnóstico de gastritis atrófica (k=0.04 a 0.12 y displasia (k=0.11 a 0.05 y buena en el diagnóstico de metaplasia intestinal (k=0.52 a 0.58; la supervisión de un patólogo inexperto por un experto mejoró notablemente la concordancia en el diagnóstico de gastritis atrófica (k=0.65 y metaplasia intestinal (k=0.91 y, en un menor grado, de displasia (k=0.28. Al comparar la concordancia entre expertos antes y después de la reunión de consenso no hubo variación en el diagnóstico de gastritis atrófica (k=0.57; la concordancia varió de buena a excelente en el de metaplasia intestinal (k=0.67 a 0.81 y de pobre a buena en el de displasia (k=0.18 a 0.66. Conclusión. Los principales problemas se presentan en el diagnóstico de la gastritis crónica atrófica y la displasia. La concordancia interobservador depende de la experiencia del observador y la lectura de consenso.Objective. The aim was to evaluate the concordance in the diagnosis of precursor lesions of intestinal-type gastric carcinoma among observers with different levels of experience. Material and Methods. Gastric biopsies from 1 056 cases were studied: 341 from Colombia, 382 from Mexico, and 333 from Paraguay. Pathologists without experience (A and with experience (B in gastrointestinal pathology, as well as experts working in an international reference center (C participated in

  7. Papel de las células mesenquimales expandidas in vitro para mejorar el injerto en el contexto del trasplante hematopoyético

    OpenAIRE

    Carrancio Antón, Soraya

    2010-01-01

    [ES] El trasplante de progenitores hematopoyéticos (TPH) es un procedimiento terapéutico destinado a reconstituir el tejido hematopoyético del paciente, que generalmente presenta una insuficiencia medular o sufre una enfermedad neoplásica. Ya a finales del S.XIX, Brown-Sequard planteó la posibilidad de reconstituir la producción de células sanguíneas en casos de anemia con la administración de bazo de animales, crudo o cocido. Pero no fue hasta los años 50 cuando se consiguió r...

  8. Parotid carcinoma

    DEFF Research Database (Denmark)

    Sørensen, Kristine Bjørndal; Godballe, Christian; de Stricker, Karin;

    2006-01-01

    OBJECTIVES: Our aim is to investigate the expression of kit protein (KIT) and epidermal growth factor receptor (EGFR) in parotid carcinomas in order to correlate the expression to histology and prognosis. Further we want to perform mutation analysis of KIT-positive adenoid cystic carcinomas....... PATIENTS AND METHODS: Formalin-fixed paraffin-embedded sections from 73 patients with parotid gland carcinomas were used for the study. The sections were stained with both KIT and EGFR polyclonal antibodies. Twelve KIT-positive adenoid cystic carcinomas were examined for c-kit mutation in codon 816....... RESULTS: Of all carcinomas 25% were KIT-positive and 79% were EGFR-positive. Ninety-two percentage of the adenoid cystic carcinomas were KIT-positive. None of the adenoid cystic carcinomas had mutations in codon 816 of the c-kit gene. CONCLUSION: Neither KIT- nor EGFR-expression seem to harbour...

  9. Mergulho em águas rasas e lesão medular: uma abordagem educativa e preventiva = Diving in shallow waters and spinal cord injury: a preventive and educational approach

    Directory of Open Access Journals (Sweden)

    Khan, Richard Lester

    2005-01-01

    Conclusão: A lesão medular causada por mergulho em águas rasas tem uma incidência elevada no mundo principalmente no período do verão. Ocorre em indivíduos jovens, sadios, geralmente do sexo masculino apresentando uma forte associação com uso de álcool. Medidas preventivas, educativas são primordiais para a diminuição de novos casos

  10. Estudio mediante tomografía computarizada de los criterios radiográficos aplicados al diagnóstico del síndrome navicular del caballo

    OpenAIRE

    Arias Sanz, Pablo

    2015-01-01

    El síndrome del navicular ha sido reconocido como una de las causas más importantes de claudicación en el caballo. En la radiografía, muchas de las lesiones del hueso navicular quedan mal definidas. Y entre ellas la pérdida de definición córtico-medular. La TC es la mejor modalidad de imagen para la valoración de las características del hueso. Pero además de la información morfológica, también proporciona información sobre la atenuación radiológica de los tejidos (tomografía computarizada cua...

  11. Estudio de eficacia y coste en la electroestimulación medular como tratamiento de la angina refractaria Cost-effectiveness study of medullary electrostimulation for the management of refractory angina

    Directory of Open Access Journals (Sweden)

    M. Mayo

    2004-07-01

    Full Text Available Objetivo: Valorar la evolución de los pacientes, de nuestro hospital, diagnosticados de angina refractaria y tratada con estimulación eléctrica medular (EEM cervical desde 1994-2002, además de valorar los costes asociados a dicho tratamiento y su relación coste/beneficio. Material y métodos: Estudio retrospectivo de 12 pacientes observando su evolución a lo largo de 8 años con controles clínicos periódicos, objetivándose tanto en la historia previa como posterior al implante, las siguientes variables: fracción de eyección del ventrículo izquierdo (FEVI, estadio funcional NYHA, frecuencia de ingresos hospitalarios, frecuencia de episodios anginosos e ingesta de cafinitrinas, sensación subjetiva de mejora del dolor anginoso, exitus, costes hospitalarios previos y posteriores a la colocación del EEM. Resultados: El electrodo de EEM fue implantado a nivel cervical siendo más frecuente la localización C2-C3 (58,3%. No se presentó ninguna complicación intraoperatoria. En el postoperatorio inmediato tuvimos como única complicación un desplazamiento del electrodo. No hubo ninguna complicación a largo plazo. Comprobamos que existió una disminución del número de anginas por semana (14 vs 4 p = 0,005 asociada a una disminución del número de tomas de nitroglicerina de acción rápida (15,7 vs 3,8 p = 0,002 y a una disminución en el número de ingresos hospitalarios/año (2,62 vs 0,84 p = 0,003. La mejoría subjetiva por parte del paciente tras la colocación del neuroestimulador fue del 70%. En cuanto al coste hospitalario quinquenal (conformado sólo por el coste del ingreso sin pruebas complementarias fue de 37.921,85 e en los pacientes con angina refractaria que no portaban EEM, frente a los 15.150,25 € de los pacientes portadores EEM.Objective: To assess the evolution of patients in our hospital with diagnosis of refractory angina treated with cervical medul-lary electrostimulation (MES over the period 1994-2002, and to

  12. Avaliação do emprego do GM1 após lesão medular experimental em ratos Evaluando el uso de GM1 después de lesión experimental de médula espinal en ratones Evaluation of the use of GM1 after experimental spinal cord injury in rats

    Directory of Open Access Journals (Sweden)

    Fabiano Inácio de Souza

    2011-01-01

    Full Text Available OBJETIVO: Avaliar a eficácia do GM1, administrado por via intraperitoneal, após lesão medular experimental em ratos. MÉTODOS: Foram utilizados 20 ratos da raça Wistar machos, adultos jovens, com média de idade de 20 semanas, pesando em torno de 350 g, divididos em dois grupos de 10 animais. No grupo 1 foi administrado apenas soro fisiológico por via intraperitoneal. Ao grupo 2, administraram-se 30 mg/kg de GM1 diariamente por essa mesma via. As lesões foram produzidas seguindo-se o protocolo internacional MASCIS (Multicenter Animal Spinal Cord Injury Study, com o sistema NYImpactor. Os animais foram avaliados funcionalmente pela escala BBB nos dias 14, 28 e 42 após a lesão. O potencial evocado foi realizado em todos os animais, no 42º dia após o trauma. RESULTADOS: Utilizou-se um modelo de variância de dois fatores (ANOVA e o teste t de Student. As avaliações funcionais e por meio de potencial evocado não demonstraram diferença estatisticamente significante entre os dois grupos. CONCLUSÃO: O emprego de GM1 intraperitoneal não demonstrou resultados satisfatórios após lesão medular experimental.OBJETIVO: Evaluar la eficacia del GM1, administrado por vía intraperitoneal, después de la lesión medular experimental en ratones. MÉTODOS: se utilizaron 20 ratones de la raza Wistar, machos, adultos jóvenes, con una edad promedio de 20 semanas, peso de 350 gramos, aproximadamente, que se dividieron en dos grupos de 10 animales. En el grupo 1 se usó solamente suero fisiológico por vía intraperitoneal. En el grupo 2, se administró por vía intraperitoneal 30 mg/kg de GM1 por día. Las lesiones fueron producidas siguiéndose el protocolo internacional MASCIS (estudio multicéntrico de lesión de médula espinal en animales por sistema NYImpactor. Los animales se evaluaron funcionalmente por la escala BBB en los días 14, 28 y 42 después de la lesión. El potencial evocado se realizó en todos los animales a los 42 días despu

  13. Carcinoma Celular Escamoso (CCE) felino

    OpenAIRE

    Roque Lagarde

    2008-01-01

    INTRODUCCIÓNEl plano nasal blanco del felino es asiento frecuente del Carcinoma Celular Escamoso (CCE). Generalmente se produce a continuación de una dermatitis actínica recidivante estacional.Su incidencia es mayor en las regiones de clima templado y en felinos que tienen por costumbre “asolearse”crónicamente y durante períodos prolongados durante los meses del verano.Las radiaciones solares no ionizantes ultravioletas (UVB) son más intensas y penetrantes a través de las capas superficiales ...

  14. Mielopatía degenerativa: estado actual del conocimiento. Revisión bibliográfica

    OpenAIRE

    Pellegrino, Fernando Carlos

    2013-01-01

    La Mielopatía Degenerativa canina (MD) es una enfermedad neurodegenerativa de comienzo tardío, diagnosticada inicialmente en el Pastor Alemán, pero que afecta muchas otras razas. Se manifiesta como un desorden medular en los perros adultos, de inicio insidioso y curso lentamente progresivo. Muchos estudios consideraron la posible etiología de MD sin poder esclarecer sus causas. Investigaciones recientes identificaron como causa probable una mutación del gen SOD1 que codifica la Su...

  15. Titration of serum anti-ganglioside antibodies in patients with chronic medular injury previous to treatment with GM1 ganglioside Titulação de anticorpos anti-gangliosídeos no soro de pacientes com lesão medular crônica e precedendo tratamento com gangliosídeo GM1

    Directory of Open Access Journals (Sweden)

    Tarcísio Eloy Pessoa Barros Filho

    2003-04-01

    Full Text Available Anti-ganglioside serum titers were evaluated by ELISA in 150 patients with complete spinal cord lesion for 6 to 12 months (IgG monosialo GM1, IgM monosialo GM1, IgG asialo GM1, IgM asialo GM1, IgG disialo GD1b e IgM disialo GD1b prior to treatment with GM1 100 mg/day i.m. Only 4 patients showed positive titers for anti-asialo-GM1 (IgM antibodies . All patients were clinically examined during and after treatment. No important side effects were observed with GM1 therapy. These results suggest that GM1-ganglioside administration in patients with chronic spinal cord injury is safe.Soro de 150 pacientes com lesão medular completa com 6 a 12 meses de duração foi analisado para titulação de anticorpos anti-gangliosídeos pelo método ELISA (IgG monosialo GM1, IgM monosialo GM1, IgG asialo GM1, IgM asialo GM1, IgG disialo GD1b e IgM disialo GD1b. Somente 4 pacientes apresentaram títulos elevados de anticorpos contra asialo GM1 (IgM. Os demais apresentaram níveis de anticorpos abaixo dos valores de referência e foram todos tratados com GM1 na dose de 100 mg por dia i.m. Todos os pacientes foram acompanhados clinicamente durante e após o tratamento com GM1. Não foram observados efeitos adversos importantes com a medicação. O tratamento de pacientes lesados medulares crônicos com o gangliosídeo GM1 mostrou-se seguro, nos pontos sem positividade sorológica para anticorpos anti-GM1 .

  16. Internet como suporte à pessoa com lesão medular: padrões de uso e reabilitação

    Directory of Open Access Journals (Sweden)

    Maira Pinto Cauchioli Rodrigues

    2012-12-01

    Full Text Available As Tecnologias de Informação e Comunicação (TIC estão em expansão na área da saúde e desencadeiam transformações nas relações profissional-usuário. Considerando, portanto, a relevância atual deste tema, o presente estudo foi desenvolvido com o objetivo de conhecer os padrões de uso e a percepção sobre internet de pessoas com lesão medular adquirida. Constataram-se diferenças estatisticamente significativas entre o tempo de uso e a influência da internet antes e após a lesão. Apesar de se verificar padrão de uso similar ao da população geral, identificaram-se especificidades que requerem atenção dos serviços especializados de reabilitação, no intuito de aprimorar rotinas de atendimento. Recomendam-se mais pesquisas em diferentes níveis assistenciais.

  17. Basisquamous Carcinoma

    Directory of Open Access Journals (Sweden)

    Yesudian Devakar P

    1997-01-01

    Full Text Available A 50 year old woman presented with an ulceroproliferative mass in the value of 4 month duration. Biopsy of the lesion showed features of a basisquamous cell carcinoma. This is a rare tumour showing histopathological features of both basal cell and squamous cell carcinomas. The clinical, histopathological and histogenetic status of this tumour are discussed.

  18. Carcinoma suprarrenal gigante Giant suprarenal carcinoma

    Directory of Open Access Journals (Sweden)

    Ariel Núñez Roca

    2010-06-01

    Full Text Available OBJETIVO: presentar un caso de carcinoma suprarrenal de gran tamaño, su diagnóstico y tratamiento. DESCRIPSIÓN: se presenta un paciente del sexo masculino, de 69 años de edad, con antecedentes de diabetes mellitus tipo II que refería palparse un tumor abdominal. Al examen físico tenía un tumor palpable en la fosa lumbar y flanco izquierdos de aproximadamente 15 a 16 cm de diámetro. El tumor se corroboró en el ultrasonido, por lo que fue necesario realizar la tomografía axial computadorizada simple y contrastada para establecer el origen suprarrenal de este. Se comprobaron niveles elevados de cortisol en plasma. INTERVENSIÓN: se realizó la suprarrenalectomía más la nefrectomía izquierdas. La evolución posoperatoria resultó satisfactoria. El informe histopatológico de la pieza quirúrgica fue carcinoma suprarrenal con infiltración renal. Se indicó tratamiento de quimioterapia con mitotano con posterioridad a la cirugía. En los controles semestral y anual realizados, el paciente se encontró asintomático y con niveles de cortisol sanguíneo normales. El ultrasonido, la tomografía axial computadorizada del abdomen y la radiografía del tórax no mostraron recidiva tumoral ni metástasis. CONCLUSIONES: los carcinomas suprarrenales pueden evolucionar de forma asintomática hasta alcanzar grandes dimensiones. El tratamiento combinado, quirúrgico y con quimioterapia, mejora el pronóstico de estos pacientes.OBJECTIVE: this is the presentation of a case of a very large suprarenal carcinoma. DESCRIPTION: a male patient aged 69 with a history of type 2 diabetes mellitus mentioning the palpation of a abdominal tumor. At physical examination we noted the presence of a palpable tumor in lumbar fossa and left flanks of approximately 15 to 16 cm diameter. Ultrasound corroborated the tumor being necessary to perform a single and contrasted computed tomography to establish its suprarenal origin. There were high levels of cortisol in plasma

  19. Modelo predictivo del grado de discapacidad en adultos con lesión medular: resultados desde el WHO-DAS II

    Directory of Open Access Journals (Sweden)

    Claudia Patricia Henao Lema

    2011-08-01

    Full Text Available Objective: To establish a prediction model of the degree of disability in adults with Spinal Cord Injury (SCI based on the use of the WHO-DAS II . Methods: The disability degree was correlated with three variable groups: clinical, sociodemographic and those related with rehabilitation services. A model of multiple linearregression was built to predict disability. 45 people with sciexhibiting diverse etiology, neurological level and completenessparticipated. Patients were older than 18 and they had more than a six-month post-injury. The WHO-DAS II and the ASIA impairment scale(AIS were used. Results: Variables that evidenced a significant relationship with disability were the following: occupationalsituation, type of affiliation to the public health care system, injury evolution time, neurological level, partial preservation zone,ais motor and sensory scores and number of clinical complications during the last year. Complications significantly associated todisability were joint pain, urinary infections, intestinal problemsand autonomic disreflexia. None of the variables related to rehabilitation services showed significant association with disability. The disability degree exhibited significant differencesin favor of the groups that received the following services: assistive devices supply and vocational, job or educational counseling. Conclusions: The best prediction disability model inadults with sci with more than six months post-injury was built withvariables of injury evolution time, AIS sensory score and injury-related unemployment.

  20. Metodología para la estimación del gasto energético en lesionados medulares mediante el empleo de acelerómetros

    OpenAIRE

    García Massó, Xavier

    2012-01-01

    Los objetivos de la tesis fueron diseñar modelos lineales generales y redes neuronales artificiales para estimar el gasto energético de personas con paraplejia. Para ello se realizó un estuio descriptivo transversal en el que 20 personas con paraplejia realizaron una rutina de 10 actividades. Cada actividad tuvo una duración de 10 minutos y durante la realización de la misma se adquirieron datos de frecuencia cardiaca, consumo de oxínego y aceleraciones. Concretamente se colocaron 4 aceleróme...

  1. Análisis epidemiológico del carcinoma de suelo de la boca en la Región de Murcia

    OpenAIRE

    Cortez Lede, María Gabriela

    2014-01-01

    OBJETIVOS Los objetivos de esta Tesis son realizar un análisis estadístico descriptivo y analítico de la muestra. Analizar la morbimortalidad postoperatoria, la supervivencia global, la supervivencia específica por enfermedad y la supervivencia libre de enfermedad de los pacientes con carcinoma epidermoide de suelo de boca. Así mismo, analizar la supervivencia específica según distintas variables como el sexo, la edad, el consumo de tabaco y alcohol, las complicaciones postquirúrgicas, el...

  2. Presentación de un modelo de decisión Bayesiano para el tratamiento del Carcinoma Ductal In Situ (CDIS) de mama.

    OpenAIRE

    Belda Ibáñez, Tatiana

    2015-01-01

    El Carcinoma de Mama (CM) es el tumor maligno más frecuente en mujeres y su incidencia aumenta un 2% anual, por ello es uno de los problemas sanitarios más importantes de los países industrializados. Los sistemas nacionales de salud se centran en su diagnóstico precoz para minimizar las consecuencias fatales de la enfermedad, con la realización de mamografías periódicas en las mujeres entre los 40 y 70 años. El desarrollo de estos programas de cribado han demostrado adelantar el diagnóstico ...

  3. Tirotropina alfa recombinante como método de estimulación en la ablación del Carcinoma Diferenciado de Tiroides

    OpenAIRE

    Mena Bares, Luisa Mª

    2011-01-01

    El Carcinoma Diferenciado de Tiroides (CDT) constituye el 90% de todas las neoplasias tiroideas. Aunque la mortalidad es baja, su morbilidad es elevada, lo que condiciona un seguimiento prolongado de los pacientes. Tras el diagnóstico, el tratamiento inicial está constituido por una tiroidectomía total o casi total, seguida de una ablación de restos tiroideos realizada con 131I, basada en la propiedad de las células tumorales tiroideas de conservar la capacidad para la captación de yodo y la...

  4. Role of multimedial diagnosis of breast cancer in women below 36 year of age; Ruolo della diagnostica integrata nella diagnosi del carcinoma mammario nelle donne con eta' inferiore ai 36 anni

    Energy Technology Data Exchange (ETDEWEB)

    Ciacco, Stefano; Brancato, Beniamino [Centro per lo studio della prevenzione oncologica, Firenze (Italy)

    2005-04-01

    mammography, 73.5% for ultrasonography and 90.9% for cytology (97.7% if inadequate samples were excluded), and overall sensitivity would be 96.1%. Conclusions: Differential diagnosis of breast cancer in women aged under 36 years is difficult, sensitivity being lower as compared to older women, with the only exception of cytology. The association of multiple tests (diagnostic imaging and cytology) is crucial to achieve an acceptable false negative rate. In particular, the extensive use of cytology in the presence of an even minimal doubt at palpation and/or imaging is strongly recommendable. Sensitivity must be calculated on the basis of an independent pathology registry, and false negatives must be defined within a given period after the test. Analysis limited to tests performed immediately before diagnosis leads to a biased over-estimation of sensitivity. [Italian] Scopo: Valutare la sensibilit� per carcinoma mammario delle diverse metodologie diagnostiche impiegate in una serie consecutiva di donne di et� inferiore ai 36 anni. Materiale e metodi: Analisi di 155 soggetti, con carcinoma incidente nel Registro Tumori Toscano dal 1985 al 2000. la sensibilit� delle metodiche � valutata rispetto all'esame pi� recente eseguito nell'anno precedente la diagnosi, in funzione di diverse variabili, quali le dimensioni del tumore e il periodo temporale. Risultati: La sensibilit� � risultata del 70.3% per l'esame clinico, 76.0% per la mammografia, 69.1% per l'ecografia e 80.6% per la citologia (86.2%, escludendo i prelievi inadeguati). La sensibilit� dipende dallo stadio per la clinica (pT1=60.6%; pT2=4=86.4%; {chi}2=10.2, p=0.001) e per l'ecografia (pT1=61.9%; pT2=4=92.0%; {chi}2=5.7, p=0.001) e dalla densit� radiologica del seno per la mammografia (densit� 50-100% =75.5%; 0-50 densit�=91.3%; {chi}2=1.85, p<0.17). Nei 112 casi esaminati con clinica, mammografia e citologia i tre metodi hanno avuto sensibilit� rispettivamente del 78.5%, 75

  5. Análisis microbiológico de úlceras de presión en pacientes del Centro Nacional de Rehabilitación (CENARE)

    OpenAIRE

    Karla Villalobos-Camacho; Mercedes Hernández-Guerrero; Susana Arteaga-Acevedo; Federico Montero-Mejía; Fernando García

    2001-01-01

    Justificación y objetivo: Las úlceras de presión son áreas localizadas de tejido necrótico que tienden a desarro-llarse cuando los tejidos blandos son comprimidos entre una prominencia ósea y una superficie externa. La principal complicación de estas lesiones es que pueden constituirse en focos primarios de infecciones bacterianas. El objetivo del presente estudio fue realizar un análisis microbiológico de las úlceras de presión en pacientes de las unidades de Lesionados Medulares, Neurotraum...

  6. Descrição da aptidão inicial para natação em lesionados medulares Description of initial swimming ability in patients with spinal cord injury

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Raposo Melo

    2009-12-01

    Full Text Available Este estudo tem por objetivos verificar o retorno à natação após a lesão medular e descrever a aptidão inicial de lesionados medulares para o nado como parte das atividades do programa de reabilitação no Hospitalar Sarah-Centro. MÉTODOS: Foram avaliados 170 pacientes com diagnóstico de paraplegia e tetraplegia, em três etapas - levantamento de dados em prontuário, entrevista oral e avaliação do padrão do nado. Os resultados apontaram que grande parte dos pacientes não entrou na piscina ou realizou nado após a lesão medular. A avaliação da adaptação ao meio líquido após a lesão medular demonstrou que grande parte dos pacientes realizou a imersão e flutuação de forma independente, porém, apresentando dificuldade em mudar de decúbito dentro da água. Apenas uma pequena porcentagem retomou a natação após a lesão medular; foi também verificada redução no total dos sujeitos que nadavam regularmente antes. A avaliação apontou que os nados crawl e de costas foram realizados por metade dos avaliados; apenas uma pequena parte realizou nado de peito. CONCLUSÃO: Após a avaliação dos relatos dos pacientes, verificou-se redução na prática da natação, seja como atividade esportiva, física ou de lazer após a lesão medular, apesar de a aptidão para o nado não ter sofrido grandes alterações.Pysical activity, particularly swimming, that brings a lot of benefits to subjects with spinal cord injury, can be started during rehabilitation. The aims of this study were to describe the initial ability to swim of patients with spinal cord injury during the rehabilitation program at the Sarah Hospital - Center. METHODS: 170 patients were evaluated in three steps - medical records data collection, oral interview and swimming evaluation. The results showed that a large proportion of patients did not enter the swimming pool or swam after spinal cord injury. Only a small part returned to swimming after the spinal cord

  7. Sebaceous Carcinoma

    Science.gov (United States)

    ... of the Year Award Arnold P. Gold Foundation Humanism in Medicine Award Diversity Mentorship Program Eugene Van ... What causes sebaceous carcinoma? SC is rare, so scientists still have much to learn, including what causes ...

  8. Estudio in vitro del efecto de la curcumina, el licopeno y la irradiación sobre el carcinoma oral de células escamosas

    OpenAIRE

    Tudela Mulero, María del Rosario

    2012-01-01

    El carcinoma oral de células escamosas (COCE) es el más común en la cavidad oral. Actualmente está aumentando el uso de productos naturales como anticancerígenos. Nosotros, desarrollamos un estudio in vitro para evaluar el efecto de la curcumina, licopeno e irradiación sobre COCE. La curcumina y el licopeno fueron administrados a dosis de 3, 4.25, 5.50 y 6.75 µM sobre cultivos de la línea celular PE/CA-PJ15 de COCE irradiados a diferentes dosis (1, 2.5 y 5 Gy), seguido de la evaluación sobre ...

  9. Últims estudis mostren una major incidència del carcinoma basocel·lular a la població espanyola

    OpenAIRE

    Bielsa, Isabel

    2010-01-01

    Els canvis en l'estil de vida que als últims anys ha experimentat la societat han incrementat l'exposició als raigs solars i això genera un augment en les afeccions de la pell entre la població caucàsica, com la neoplàsia (proliferació anormal de les cèl·lules d'un teixit). El carcinoma basocelular és una de les més comunes i, encara que no té un alt índex de mortalitat, s'està convertint en un seriós problema al que no se li està prestant la suficient atenció epidemiològica. Estudis realitza...

  10. Relación entre complicaciones clínicas y discapacidad en población colombiana con lesión medular: resultados desde el WHO-DAS II

    OpenAIRE

    Julio Ernesto Pérez Parra; Claudia Patricia Henao Lema

    2013-01-01

    Introducción: las complicaciones clínicas en personas con lesión medular se asocian al aumento de la morbimortalidad, agravamiento de la condición de discapacidad y a la prolongación de los procesos de rehabilitación. Es importante su reconocimiento para el desarrollo de estrategias de prevención y atención temprana más eficaces que atenúen su impacto sobre la discapacidad y mejoren la calidad de vida de esta población. Objetivo: establecer las relaciones entre complicaciones clínicas y el...

  11. Estudio de eficacia y coste en la electroestimulación medular como tratamiento de la angina refractaria Cost-effectiveness study of medullary electrostimulation for the management of refractory angina

    OpenAIRE

    Mayo, M.; Pallarés, J; C. Villalaín; A. Moreno-Gázquez; M. A. Canos; Almenar, L.

    2004-01-01

    Objetivo: Valorar la evolución de los pacientes, de nuestro hospital, diagnosticados de angina refractaria y tratada con estimulación eléctrica medular (EEM) cervical desde 1994-2002, además de valorar los costes asociados a dicho tratamiento y su relación coste/beneficio. Material y métodos: Estudio retrospectivo de 12 pacientes observando su evolución a lo largo de 8 años con controles clínicos periódicos, objetivándose tanto en la historia previa como posterior al implante, las siguientes ...

  12. Ressonância magnética na mielopatia associada ao HTLV-I: Leucoencefalopatia e atrofia medular Magnetic resonance in HTLV-I associated myelopathy: leukoencephalopathy and spinal cord atrophy

    Directory of Open Access Journals (Sweden)

    Ana Claudia Ferraz

    1997-01-01

    Full Text Available Lesões na substância branca cerebral e atrofia medular têm sido descritas em pacientes com mielopatia associada ao HTLV-I (MAH. A freqüência e a importância clínica destes achados ainda não são totalmente conhecidas. Vinte e nove pacientes foram estudados por ressonância magnética (RM do crânio e da coluna. Imagens com hipersinal em T2 na substância branca, de diâmetro igual ou superior a 3 mm foram consideradas anormais. O tamanho da medula foi avaliado usando índice por nós denominado "índice medular". Os achados neurorradiológicos foram correlacionados às características clínicas da mielopatia. Lesões na substância branca cerebral ocorreram em 52% dos pacientes e atrofia medular ocorreu em 74%. Não houve correlação entre os achados neurorradiológicos e as características clínicas estudadas. Os resultados sugerem que a RM é um método útil na detecção de anormalidades cerebrais e medulares em pacientes com MAH. As lesões de substância branca não apresentaram correlação com idade ou com fatores de risco cardiovascular e podem estar associadas à infecção pelo vírus HTLV-I.Cerebral white matter lesions and spinal cord atrophy have been frequently reported in patients with HTLV-I associated myelopathy (HAM. The exact frequency and the clinical relevance of these findings still remain to be elucidated. Twenty-nine patients with HAM were studied by magnetic resonance imaging of the brain and spine. Cerebral white matter lesions equal or over 3 mm in diameter were considered abnormal. The spinal cord size was evaluated using an index we have called "spinal cord index". The radiological findings were correlated to the clinical features of the myelopathy. Cerebral white matter lesions occurred in 52% of the patients, and spinal cord atrophy in 74%. There was no significant correlation between these abnormalities and the clinical features studied. These findings suggest that the resonance imaging is a useful

  13. Esclerose múltipla, ependimoma medular e meningioma intracraniano: relato de caso Multiple sclerosis, spinal cord ependymoma and intracranial meningioma: case report

    Directory of Open Access Journals (Sweden)

    MÔNICA F. COSTA

    2000-12-01

    Full Text Available Relatamos a associação impar entre esclerose múltipla (EM, tumor medular e tumor intracraniano em uma paciente de 63 anos de idade e com EM há dez anos com evolução em surtos de remissão e exacerbação. Havia melhora dos sintomas com o uso de corticosteróides. Em 1997 apresentou paraparesia crural e do membro superior direito, de instalação progressiva e que não respondeu à corticoterapia. A ressonância magnética da coluna cervical evidenciou tumor intramedular, que se revelou um ependimoma, e a do crânio, a presença de meningioma parietal à esquerda. Ressaltamos a associação incomum entre tumores do sistema nervoso central e EM e enfatizamos a necessidade de investigação clínica e por imagem diante de uma manifestação ou evolução clínica incomum no curso da doença.We report the association a multiple sclerosis (MS, spinal cord tumour and intracranial tumor in a 63 years-old female patient with a 10 years history of relapsing/remitting MS. Symptoms usually remitted in response to costicosteroid therapy. In 1997 the patient presented with paraparesis and paresis of right arm which did not respond to corticotherapy. A spinal RMI revealed in the cervical spinal an intra spinal cord tumour, further diagnosed as ependymoma, and a parietal region meningioma. We call attention to this rare association of central nervous system tumour and MS, enphasizing the need for investigation of new and uncommon symptoms during the evolution of MS.

  14. Neoplasia endocrina múltiple tipo-2b

    OpenAIRE

    Lastra, Guido; de Franco, Roberto; Rueda P., Pedro Nel; Pradilla S., Lina P.; Paz C., Óscar

    2014-01-01

    La neoplasia endocrina multiple tipo 2 comprendetres sindromes : la neoplasia endocrina múltiple2A con predisposición genética para desarrollarcarcinoma medular del tiroides,feocromocitoma e hiperplasia primaria deparatiroides. La neoplasia endocrina múltiple 2B,desorden autosómico dominante con feocromocitomay carcinoma medular del tiroides quegeneralmente se presenta a una edad más tempranay es más agresivo que la de tipo 2A, porlo que su diagnóstico precoz es crítico; estospacientes, que t...

  15. Determination of the phosphorylated neurofilament subunit NF-H (pNF-H in cerebro-spinal fluid as biomarker in acute traumatic spinal cord injuries / Dozarea neurofilamentelor fosforilate (subunitatea pNF-H ȋn LCR ca biomarker ȋn traumatismul vertebro-medular acut

    Directory of Open Access Journals (Sweden)

    Ungureanu Didona

    2014-09-01

    Full Text Available Obiectivul studiului. Obiectivul acestui studiu a fost dozarea neurofilamentelor fosforilate (subunitatea pNF-H în lichidul cefalorahidian al pacienţilor cu leziuni traumatice ale măduvei spinării şi stabilirea unei corelaţii intre valoarea pNF-H şi gravitatea leziunilor medulare. Material şi metode. Studiul a inclus 15 pacienţi cu leziuni traumatice acute medulare: opt pacienţi cu leziuni medulare complete şi şapte pacienţi cu leziuni medulare incomplete. Gravitatea leziunilor medulare a fost apreciată folosind scala ASIA (American Spinal Injury Association scale şi la toti pacientii s-a aplicat tratamentul chirurgical în primele 24 de ore (decompresiune medulară şi stabilizare vertebrală. S-a facut determinarea zilnică a pNF-H din LCR folosind testul ELISA specific şi am corelat aceste valori cu evoluţia clinică. Rezultate. Subunitatea pNF-H a fost evidenţiată în LCR la toţi pacienţii cu traumatisme acute vertebro-medulare şi valorile au fost diferite în cazurile leziunilor medulare complete faţa de leziunile incomplete. Nivelul pNF-H din LCR a fost de zece până la o sută de ori mai mare în leziunile medulare complete fata de cazurile cu leziuni incomplete, unde nivelul acestui biomarker a fost aproape normal. Pacienţii cu o evoluţie neurologică favorabilă după tratament au avut un model specific al valorilor zilnice de pNF-H: o creştere bruscă până la o valoare maximă apoi o scădere progresivă până la normal. Valorile maxime au fost diferite în fiecare caz, de 10 ori până la 170 de ori mai mari faţă de normal. Concluzii. Forma fosforilată a subunităţii neurofilamentelor cu greutate moleculară mare pNF-H din lichidul cefalorahidian poate fi un biomarker specific pentru leziunile acute traumatice ale măduvei spinării corelat cu severitatea leziunilor medulare. pNF-H pare a fi un biomarker predictiv deoarece modelul evolutiv al valorilor sale arată reducerea sau blocarea leziunilor

  16. Effects of hyperbaric oxygen therapy after spinal cord injury: systematic review Efectos de la terapia hiperbárica en el traumatismo raquimedular: revisión sistemática Efeitos da oxigenioterapia hiperbárica no tratamento da lesão medular traumática: revisão sistemática

    Directory of Open Access Journals (Sweden)

    Asdrubal Falavigna

    2009-09-01

    Full Text Available OBJECTIVE: to conduct a systematic review of experimental and clinical studies evaluating the effect of hyperbaric oxygen therapy on the spinal cord injury. METHODS: ninety-three studies were identified in the database Pubmed. Among these, through a set of inclusion/exclusion criteria, 11 articles published between 1963 and 2009 were selected. In the nine experimental studies, different ways to apply the treatment were observed. The measured outcomes were: functional, histological, biochemical and electrophysiological. RESULTS: in most of the studies, the results show recovery of locomotor function, histology and/or biochemical features. Regarding the two studies in clinical samples, the results are controversial. The samples are heterogeneous and the application of hyperbaric oxygen therapy is not the same for all patients in each study. CONCLUSION: considering the results of this review, further studies are necessary to define the role of hyperbaric oxygen therapy in acute spinal cord injury.OBJETIVO: realizar una revisión sistemática de estudios experimentales y clínicos que evaluaban los efectos de la terapia hiperbárica en el traumatismo raquimedular. MÉTODOS: se identificaron noventa y tres estudios en el Pubmed. De estos, por un conjunto de criterios de inclusión y exclusión, se seleccionaron 11 artículos publicados entre 1963 y 2009. Entre los nueve estudios experimentales, se observaron diferentes formas de aplicación del tratamiento. Los resultados mensurados fueron: funcional, histológico, bioquímico y electrofisiológico. RESULTADOS: los resultados muestran, en la mayoría de los estudios, recuperación de la función locomotora, histología y/o características bioquímicas. Tratándose de los estudios clínicos, los resultados son controvertidos. Las muestras son heterogéneas y la aplicación de la terapia hiperbárica no es igual para todos los pacientes en cada estudio. CONCLUSIÓN: considerando los resultados de esta

  17. Carcinoma multiplex

    International Nuclear Information System (INIS)

    Multiple primaries in a single patient are uncommon, though not very rare. The existence of such cancers in two un-related, non-paired organs is even more un-common. Here, we present a case of 55 years old male who presented to us with a mucoepidermoid carcinoma of the parotid gland and was operated. Later on, he presented with a large cystic swelling in the pelvis which turned out to be pseudomyxoma peritonei. A review of slides and immunohistochemistry indicated it to be adenocarcinoma colon. He presented again with recurrent mucoepidermoid carcinoma of the parotid which was operated successfully with the use of myocutaneous flap for wound closure. He is currently undergoing chemotherapy. In order to establish a separate mono-clonal etiology of both tumours, immunohistochemistry was performed. To the best of our knowledge, carcinoma multiplex in the colon and the parotid has never been reported before. (author)

  18. Parotid carcinoma

    DEFF Research Database (Denmark)

    Godballe, Christian; Schultz, Joyce H; Krogdahl, Annelise;

    2003-01-01

    OBJECTIVE: To analyze clinical data and possible prognostic factors of patients with primary carcinoma of the parotid gland. STUDY DESIGN: A retrospective study was made of 85 patients with suspected parotid cancer who were admitted to the Center of Head and Neck Oncology at Odense University...... guidelines from the World Health Organization. Five tumors (6%) did not fulfill the criteria of malignancy and were reclassified as benign. In another five cases the assumed primary parotid carcinomas were found to be metastatic disease from cancers of the breast, prostate, skin, and lungs. Ten patients (12...... significant influence on survival. CONCLUSIONS: A thorough histological revision is pivotal in retrospective parotid carcinoma studies, and tumor size; histological appearance; T, N, and M status; stage; facial nerve dysfunction; and pain from the face and/or neck seem to be significant prognostic indicators...

  19. Tratamiento del cáncer por captura neutrónica de boro: Su aplicación al carcinoma indiferenciado de tiroides Boron neutron capture therapy applied to undifferentiated thyroid carcinoma

    Directory of Open Access Journals (Sweden)

    Mario A. Pisarev

    2006-12-01

    Full Text Available El cáncer indiferenciado de tiroides es un tumor muy agresivo, de muy mal pronóstico y sin tratamiento efectivo. La terapia por captura neutrónica de boro (BNCT podría ser una alternativa para el tratamiento de esta enfermedad. Se basa en la captación selectiva de boro por el tumor y su activación por un haz de neutrones. El boro activado libera un núcleo de litio-7 y una partícula alfa, las cuales tienen una alta transmisión linear de energía (linear energy transfer, LET y un alcance de 5-9 µm, destruyendo el tumor. En estudios previos hemos mostrado que la línea celular humana de cáncer indiferenciado de tiroides (ARO tiene una captación selectiva de borofenilalanina (10BPA tanto in vitro como después de ser implantada en ratones NIH nude. También demostramos en estos animales inyectados con BPA e irradiados con un haz de neutrones térmicos, un 100% de control sobre el crecimiento tumoral y un 50% de cura histológica. En trabajos posteriores mostramos que la porfirina 10BOPP tetrakis-carborane carboxylate ester de 2,4-bis-(a,b-dihydroxyethyl-deutero-porphyrin IX cuando es inyectada 5-7 días antes que el BPA se obtiene una concentración tumoral de boro de aproximadamente el doble que el BPA solo (45-38 ppm vs. 20 ppm. La posterior irradiación con neutrones mostró un 100% de remisión completa en animales con tumores cuyo volumen pre-tratamiento era de 50 mm³ o menor. Los perros padecen CIT espontáneo, con un comportamiento biológico similar al humano, y una captación selectiva de BPA, abriendo la posibilidad de su tratamiento por BNCT.Undifferentiated thyroid carcinoma (UTC is an aggressive tumor with a poor prognosis due to the lack of an effective treatment. Boron neutron capture therapy (BNCT is based on the selective uptake of boron by the tumor and its activation by a neutron beam, releasing lithium-7 and an alpha particle that will kill the tumor cells by their high linear energy transfer (LET. In previous

  20. Spinal cord schistosomiasis in children: analysis of seven cases Esquistossomose medular em crianças: análise de sete casos

    Directory of Open Access Journals (Sweden)

    José Albino da Paz

    2002-06-01

    ógico, ajudou a confirmar a forma e o nível medular da lesão.

  1. Parathyroid carcinoma

    DEFF Research Database (Denmark)

    Qvist, N; Krøll, L; Ladefoged, C;

    1986-01-01

    Parathyroid carcinoma is a slow growing tumor, and the patients most often die from complications to the hypercalcemia. Therefore, any attempt should be made to remove local recurrence and metastasis surgically, as medical treatment is disappointing. A case treated with extensive vascular surgery...

  2. Articulando la sostenibilidad ecológica, económica y social: el caso del cacahuate orgánico

    Directory of Open Access Journals (Sweden)

    Pedro Figueroa Bautista

    2005-01-01

    Full Text Available En este trabajo se analiza la experiencia del sistema socioproductivo del cacahuate orgánico en el ejido La Ciénega en la Costa Sur de Jalisco. Esta leguminosa es un caso particular entre las múltiples alternativas productivas capaces de fortalecer procesos sociales, económicos, culturales y ambientales. Además, se discute la importancia de este cultivo desde el enfoque de la sostenibilidad: como práctica cultural, de conservación del ambiente y como práctica de justicia social, por ejemplo. Parte medular de este texto es la búsqueda y fortalecimiento de estrategias dirigidas a lograr un desarrollo rural endógeno, así como el empoderamiento de las unidades familiares, grupos de productores y uniones de organizaciones que luchan por generar procesos de desarrollo rural alternativos al modelo de desarrollo dominante.

  3. ANÁLISIS RETROSPECTIVO DEL CARCINOMA CUTÁNEO TIPO BASOCELULAR Y ESCAMOCELULAR EN BOGOTÁ-COLOMBIA: EPIDEMIOLOGÍA, PREVENCIÓN Y TRATAMIENTO A retrospective analysis of basall cell and squamous cell skin carcer in Bogota, Colombia: its epidemiology, prevention and treatment

    OpenAIRE

    óscar Iván Barón Estrada; Julián álvarez Sierra; Giovanni Montealegre Gómez

    2009-01-01

    Antecedentes. El carcinoma cutáneo no melanoma del tipo basocelular (CBC) y escamocelular (CEC), tiene tasas de incidencia cercanas al 13 por ciento y es el más prevalente en la población blanca. Trae elevada morbilidad para el paciente y altos costos para el sistema de salud, y aunque es la neoplasia maligna mas frecuentemente diagnosticada, en Colombia sólo se tienen estadísticas en instituciones oncológicas, haciendo énfasis principalmente en melanomas. Entre los principales factores de ri...

  4. Medullary carcinoma of thyroid

    Science.gov (United States)

    Thyroid - medullary carcinoma; Cancer - thyroid (medullary carcinoma); MTC ... The cause of medullary carcinoma of the thyroid (MTC) is unknown. Unlike other types of thyroid cancer, MTC is less likely to be caused by radiation therapy to the neck given ...

  5. Basal Cell Carcinoma (BCC)

    Science.gov (United States)

    ... epithelioma, is the most common form of skin cancer. Basal cell carcinoma usually occurs on sun-damaged skin, especially ... other health issues. Infiltrating or morpheaform basal cell carcinomas: Infiltrating basal cell carcinomas can be more aggressive and locally destructive ...

  6. Estudio de la frecuencia, distribución y rendimiento diagnóstico en las lesiones neoplásicas sincrónicas del carcinoma colo-rectal Study of frequency, distribution and diagnostic performance in synchronic neoplastic lesions of colorectal carcinoma

    Directory of Open Access Journals (Sweden)

    A. Borda

    2008-04-01

    Full Text Available Objetivo. Analizar la frecuencia, características y el diagnóstico de las lesiones neoplásicas sincrónicas en el cáncer colo-rectal. Material y métodos. Se han revisado 384 cánceres colo-rectales, diagnosticados mediante colonoscopia completa y resecados. Se ha determinado los cánceres sincrónicos y las características de los adenomas: número, tamaño, tipo histológico, displasia, así como su localización en el colon y respecto al carcinoma. Resultados. Se han encontrado 28 cánceres sincrónicos (7,3% del global: 8 tumores desarrollados y 20 pólipos malignizados. El 54,4% de los casos tenía algún adenoma sincrónico. En los pacientes con lesiones sincrónicas, un 43% presentaba un adenoma avanzado. El 20% de los pólipos sincrónicos encontrados fueron proximales al ángulo esplénico; distales el 41% y con ambas localizaciones el 38%. El 59,1% de los pacientes tenía algún adenoma proximal con respecto al cáncer, con criterios de adenoma avanzado en el 13,9%. La distribución de los adenomas estuvo más uniformemente repartida en los cánceres de localización proximal (p = 0,038. Un 17% de los cánceres distales presentó lesiones sincrónicas localizadas exclusivamente en colon proximal. Las endoscopias parciales diagnosticarían los cánceres distales, pero omitirían un adenoma sincrónico en el 42,3% de las sigmoidoscopias y en el 40% de las colonoscopias cortas. Conclusiones. Se registraron unas elevadas tasas de carcinoma y adenomas sincrónicos. Destacamos el alto índice de adenomas avanzados y la frecuencia de lesiones sincrónicas proximales al cáncer, por lo que las colonoscopias incompletas, aunque permitan el diagnóstico del cáncer distal, omiten un alto porcentaje de adenomas sincrónicos, incluyendo lesiones avanzadas. Todo ello confirma la necesidad de efectuar una colonoscopia completa pre, intra o post-quirúrgica en el cáncer colo-rectal resecable.Aim. To analyse the frequency, characteristics and

  7. Avaliação clínica e por ressonância magnética do ombro de pacientes lesados medulares Clinical assessment and magnetic resonance imaging of the shoulder of patients with spinal cord injury

    OpenAIRE

    Alex Pereira Alves; Alberto Antonio Terrabuio Junior; Ciro Jabur Pimenta; Giovanna Ignácio Subirá Medina; Carolina de Medeiros Rimkus; Alberto Cliquet Júnior

    2012-01-01

    OBJETIVO: Estudar o ombro destes indivíduos através de ressonância magnética para detectar lesões clínicas ou subclínicas para instituir programas específicos de reabilitação. MÉTODOS: Foram avaliados nove pacientes lesados medulares, com seguimento no Laboratório de Biomecânica e Reabilitação do Aparelho Locomotor HC/UNICAMP. Foram divididos em dois grupos de acordo com a presença de paraplegia ou tetraplegia e avaliados através de anamnese e exame físico para correlação com o exame de image...

  8. Ressonância magnética na mielopatia associada ao HTLV-I: Leucoencefalopatia e atrofia medular Magnetic resonance in HTLV-I associated myelopathy: leukoencephalopathy and spinal cord atrophy

    OpenAIRE

    Ana Claudia Ferraz; Alberto Alain Gabbai; Nitamar Abdala; Roberto Gomes Nogueira

    1997-01-01

    Lesões na substância branca cerebral e atrofia medular têm sido descritas em pacientes com mielopatia associada ao HTLV-I (MAH). A freqüência e a importância clínica destes achados ainda não são totalmente conhecidas. Vinte e nove pacientes foram estudados por ressonância magnética (RM) do crânio e da coluna. Imagens com hipersinal em T2 na substância branca, de diâmetro igual ou superior a 3 mm foram consideradas anormais. O tamanho da medula foi avaliado usando índice por nós denominado "ín...

  9. A musculatura epaxial e a fibrose epidural na compressão medular em cães submetidos à laminectomia dorsal modificada

    Directory of Open Access Journals (Sweden)

    Diego V. Beckmann

    2010-02-01

    Full Text Available O objetivo deste experimento foi isolar a musculatura epaxial da medula espinhal de cães submetidos à laminectomia dorsal modificada (LDM e averiguar se os músculos influenciaram na formação da fibrose epidural, na compressão medular e no aparecimento dos sinais neurológicos. Para isso, dez cães hígidos foram submetidos à LDM entre as vértebras T13 e L1 e distribuídos aleatoriamente em dois grupos denominados controle (I onde a medula espinhal permaneceu exposta sem a presença de implante, e tratado (IIonde foi colocado um im-plante a base de alumínio entre a musculatura epaxial adjacente e a medula espinhal exposta pela LDM. As avaliações constaram de exames neurológicos diários até 180 dias de pós-operatório (PO; mielografia, decorridos 15, 30 e 60 dias de PO; e avaliação macroscópica mediante a reintervenção cirúrgica. Não houve diferença durante as avaliações neurológicas. Aos 15 dias de PO, foi verificado na mielografia, que o grau de compressão da linha de contraste foi maior no grupo tratado (PThe purpose of this study was to isolate the adjacent epaxial musculature from exposed spinal cord by modified dorsal laminectomy in dogs with aluminum implant and to verify whether the muscles contribute to form epidural fibrosis, spinal cord compression, and development of neurological signs. Ten dogs were submitted to modified dorsal laminectomy between T13 and L1 and then distributed along two groups. Dogs in the group 1 remained with the spinal cord exposed without the implant; dogs in the group 2 had an aluminum implant inserted between the epaxial muscles and the exposed spinal cord. Neurological examination was daily performed until 180 days post surgery. Additionally, myelography at 15, 30, and 60 days post surgery and macroscopic evaluation of the implant at six months post surgery were done. There was no difference between groups in the neurological examination. A statistical difference in the degree of

  10. Carcinoma Celular Escamoso (CCE felino

    Directory of Open Access Journals (Sweden)

    Roque Lagarde

    2008-12-01

    Full Text Available INTRODUCCIÓNEl plano nasal blanco del felino es asiento frecuente del Carcinoma Celular Escamoso (CCE. Generalmente se produce a continuación de una dermatitis actínica recidivante estacional.Su incidencia es mayor en las regiones de clima templado y en felinos que tienen por costumbre “asolearse”crónicamente y durante períodos prolongados durante los meses del verano.Las radiaciones solares no ionizantes ultravioletas (UVB son más intensas y penetrantes a través de las capas superficiales de la piel durante los meses del verano y entre las 10 hs. y las 16 hs. (incidencia perpendicular de los rayos por lo que deberán ser evitadas.Siendo la nariz del gato una zona tan visible, llama la atención, que ciertas lesiones iniciales, algunas de regular tamaño (2mm, no sean advertidas por sus dueños y ocasionalmente, tenidas poco en cuenta por algunos profesionales.Posiblemente, el desconocimiento de la gravedad potencial de esta afección sea la causa de este proceder

  11. Thyroid carcinoma

    International Nuclear Information System (INIS)

    Differentiated thyroid carcinoma was studied with regard to mode of presentation, initial findings, treatment and survival. The classic signs, symptoms, physical and scan findings were found to be present in approximately 70% of the patients. Prognosis was found to be dependent on age of presentation more than any other factor. Patients with prior exposure to radiation were found to have more extensive disease and require more extensive surgery but ultimately had the same prognosis for 15-year cure. Treatment for distant metastatic disease by surgery, radioactive iodine and external radiation all resulted in long-term survival in certain cases

  12. Carcinoma verrugoso en paciente joven Verrucous carcinoma in young patient

    Directory of Open Access Journals (Sweden)

    LN Rosa

    2003-06-01

    Full Text Available El carcinoma verrucoso es una variación de bajo grado de malignidad del carcinoma de células escamosas oral, y la mayoría surge en la mucosa oral de individuos que mascan tabaco de forma crónica (6, 8, 10. Estas lesiones encontradas predominantemente en hombres, con más de 55 años de edad (edad promedio de 65 a 70 anos y las regiones de mayor frecuencia en mucosa bucal incluyen vestíbulo mandibular, mucosa yugal y palato duro (6, 8. La lesión aparece como una placa espesa, difusa, bien demarcada e indolora, con proyecciones superficiales papilares o verruciformes. Microscópicamente, se observa la presencia de crestas interpapilares anchas y alargadas y producción abundante de ceratina (2. La metástasis es un evento raro en los carcinomas verrucosos (6, 8, 9. El tratamiento de elección es la excisión quirúrgica, asociada o no a la radioterapia. Los autores relatan un caso clínico de una paciente de 13 años de edad con lesión comprometiendo todo lo vermellion del labio inferior. El tratamiento inicial propuesto fue la radioterapia asociado a la quimioterapia, decido a la edad de la paciente, localización y extensión de la lesión. Después de una dosis total de 70Gy, hubo la regresión total de la lesión. Siendo así, el tratamiento del carcinoma verrucoso asociando a la radioterapia y quimioterapia se mostró adecuado en este caso.The verrucous carcinoma is a low grade variant of oral squamous cell carcinoma, and it mostly appears in the oral mucosa of individuals who chew tobacco chronically 6, 8, 10. The lesions are mainly found in men over 55 years old (average age 65 to 70 years and the most common regions in the oral mucosa include the mandibular vestibule, jugal mucosa and hard palate 6, 8. The lesion appears as a well-defined painless diffuse thick plaque with superficial papillary or verruciform projections. Under the microscope the presence of wide elongated interpapilIary ridges and copious keratin production are

  13. Chromophobe Renal Cell Carcinoma

    OpenAIRE

    Jyotsna Vijaykumar Wader; Sujata S Kumbhar; Huddedar AD; Wasim GM Khatib

    2013-01-01

    Renal cell carcinoma is the most common neoplasm of the kidney comprised of different histological variants. Chromophobe renal cell carcinoma (ChRCC) is a rare subtype of renal cell carcinoma (RCC) mainly diagnosed in the sixth decade of life. It is important to identify this entity because it has significantly better prognosis than the clear cell (conventional) and papillary renal cell carcinomas. The chromophobe renal cell carcinoma should be differentiated from oncocytoma and clear cell ca...

  14. Alteraciones de la función renal en la cirrosis hepática experimental: papel del óxido nítrico

    OpenAIRE

    Ortiz Ruiz, María Clara

    1998-01-01

    En esta tesis hemos evaluado la participación del óxido nítrico (NO), inducible (iNOS) y constitutivo (cNOS), en las alteraciones vasculares y renales de la cirrosis hepática experimental. Los principales resultados son: 1) Las ratas cirróticas presentan una hiporrespuesta vascular aórtica a fenilefrina debida a una mayor producción de cNOS endotelial. 2) El riñón cirrótico muestra una redistribución del flujo sanguíneo hacia la región medular (medido mediante micro-tomografía com...

  15. Responsabilidad social en las universidades del municipio Maracaibo del estado Zulia

    Directory of Open Access Journals (Sweden)

    Mary Urdaneta

    2016-01-01

    Full Text Available La responsabilidad social es una temática que en los últimos años ha alcanzado notoriedad en las Instituciones de Educación Superior. El propósito de esta investigación es analizar la responsabilidad social en las universidades del municipio Maracaibo, estado Zulia (Venezuela. Se trató de una investigación analítica, con diseño no experimental de fuente mixta. La población estuvo conformada por siete (7 universidades públicas y privadas ubicadas en el municipio Maracaibo. Se diseñaron cinco instrumentos para medir responsabilidad social, considerando el enfoque teórico propuesto por Vallaeys (2007, 2008 y 2011, que incluye las políticas de responsabilidad social, docencia, gestión interna, investigación y extensión. Los resultados arrojaron que las universidades tienen diseñadas políticas de responsabilidad social, las cuales deben ser reforzadas y difundidas entre la comunidad universitaria. Mantienen un enfoque parcial de aplicación de esas políticas, al realizar su acción social a través de la extensión. La responsabilidad social en las Instituciones de Educación Superior debe ser implementada en sus cuatro procesos medulares: docencia, investigación, extensión y gestión interna.

  16. Gasimetría arterial y espirometría en individuos con lesión medular crónica residentes en Bogotá, D.C / Blood gas and spyrometry in Bogotá inhabitants with chronic spinal cord injury

    OpenAIRE

    Rodríguez Vera, Johanna Milena

    2010-01-01

    Describir los valores de gasimetría arterial y espirometría en individuos que presentan lesión medular crónica que residen en la ciudad de Bogotá, D.C. Sujetos y métodos. En 12 sujetos que presentan Lesión Medular Crónica (más de 1 año de evolución) y en 17 controles sanos que residen en la ciudad de Bogotá, se tomó con un equipo I-Stat una gasimetría arterial convencional (pH, PaO2, PaCO2, HCO3, SaO2), Hb, Hcto, Exceso de Base y se calcularon los Hidrógenos metabólicos (H-met). De igual mane...

  17. Diagnóstico diferencial das lesões inflamatórias e infecciosas do cone medular utilizando a ressonância magnética Magnetic resonance imaging in the differential diagnosis of infectious and inflammatory conus medullaris lesions

    OpenAIRE

    Gustavo Balthazar da Silveira Carvalho; Gabriel Barbosa Sandim; Luis Antônio Tobaru Tibana; Franklin Freitas Tertulino; Marcos Hideki Idagawa; Nitamar Abdala

    2013-01-01

    O cone medular é frequentemente acometido por lesões de etiologia inflamatória e infecciosa, muitas vezes de difícil diferenciação devido a história clínica e exame físico semelhantes entre as diversas entidades. A ressonância magnética apresenta alta sensibilidade na detecção de lesões no cone medular e tem importante papel no diagnóstico e controle evolutivo. Este ensaio iconográfico com casos selecionados dos arquivos do nosso serviço tem como objetivo demonstrar achados de imagem que poss...

  18. Vulvar carcinoma

    International Nuclear Information System (INIS)

    Purpose: Controversies exist regarding the use of radiation therapy in the treatment of vulvar carcinoma. A retrospective review was performed to evaluate our institution's experience with surgery and radiation for this disease. Methods and Materials: The medical records of 47 patients treated for squamous cell carcinoma of the vulva at our institution (1974-1992) were reviewed for TNM stage (AJCC criteria), treatment modality, and associated 5-year local control and survival based on Kaplan-Meier analysis. Results: Twenty-eight patients (60%) presented with Stage I and II disease and their 5-year survival was 69%. Stage III patients accounted for 12 (25%) of the patients and their 5-year survival was 73%. Seven patients presented with Stage IV disease and five died within 13 months of diagnosis after predominantly palliative therapy. The 40 patients with Stages I, II, and III disease were treated aggressively and were further evaluated for treatment-modality-associated survival and local control. Radiation therapy was used as primary treatment in nine patients, of whom seven were treated with radiation alone and two were treated postoperatively after wide excision. Surgery alone was performed in 31 patients consisting of either radical vulvectomy (20 patients) or wide excision (11 patients). When comparing outcomes of radical vulvectomy vs. radiation therapy, we noted that the 5-year actuarial survivals were comparable (74% for either modality), despite the presence of more favorable prognostic factors in the group treated with radical vulvectomy. Patients treated with wide excision alone had a trend for a poorer 5-year actuarial survival (51%) and local control (50%). Conclusions: Radical vulvectomy offers good locoregional control and survival. This retrospective review further supports the use of radiation therapy with conservative surgery as an alternative treatment option for patients with vulvar carcinoma treated with curative intent. In contrast, the use of

  19. Giant basal cell carcinoma Carcinoma basocelular gigante

    Directory of Open Access Journals (Sweden)

    Nilton Nasser

    2012-06-01

    Full Text Available The basal cell carcinoma is the most common skin cancer but the giant vegetating basal cell carcinoma reaches less than 0.5 % of all basal cell carcinoma types. The Giant BCC, defined as a lesion with more than 5 cm at its largest diameter, is a rare form of BCC and commonly occurs on the trunk. This patient, male, 42 years old presents a Giant Basal Cell Carcinoma which reaches 180 cm2 on the right shoulder and was negligent in looking for treatment. Surgical treatment was performed and no signs of dissemination or local recurrence have been detected after follow up of five years.O carcinoma basocelular é o tipo mais comum de câncer de pele, mas o carcinoma basocelular gigante vegetante não atinge 0,5% de todos os tipos de carcinomas basocelulares. O Carcinoma Basocelular Gigante, definido como lesão maior que 5 cm no maior diâmetro, é uma forma rara de carcinoma basocelular e comumente ocorre no tronco. Este paciente apresenta um Carcinoma Basocelular Gigante com 180cm² no ombro direito e foi negligente em procurar tratamento. Foi realizado tratamento cirúrgico e nenhum sinal de disseminação ou recorrência local foi detectada após 5 anos.

  20. Prostata carcinomas

    International Nuclear Information System (INIS)

    Pre-operative staging, using transrectal prostatic sonography and CT, was carried out in 30 patients with cytologically confirmed carcinomas of the prostate and the results compared with the clinical findings. All patients underwent radical prostatectomy and the pre-operative findings could be verified histologically. Transrectal prostatic sonography is better than CT or clinical examination for determining local tumour spread or penetration of the capsule. A high proportion of enlarged pelvic lymphnodes shown by CT had non-specific changes; failure to demonstrate enlarged nodes excludes lymph node metastases with considerable certainty. Transrectal prostatic sonography provides a higher degree of information regarding local tumour spread, whereas CT indicates the presence or absence of lymph node metastases. (orig.)

  1. Nevoid Basal Cell Carcinoma Syndrome

    Science.gov (United States)

    ... Nevoid Basal Cell Carcinoma Syndrome Request Permissions Nevoid Basal Cell Carcinoma Syndrome Approved by the Cancer.Net Editorial Board , 04/2016 What is Nevoid Basal Cell Carcinoma Syndrome? Nevoid Basal Cell Carcinoma Syndrome (NBCCS) is ...

  2. Estrategias de reorganización empresarial: algunas reflexiones de empresas del sector agroalimentario

    Directory of Open Access Journals (Sweden)

    Meleán, Rosana

    2010-05-01

    Full Text Available En este trabajo, se plantea analizar las estrategias que están adoptando las empresas del sector agroalimentario para hacer frente a los problemas económicos, políticos y sociales del contexto en el que se encuentran inmersas. La investigación es de tipo analítica, bajo un diseño no experimental, de campo; basada en autores como Gamboa et al. (2003a y 2003b, Puente (2007, Biasca (1991, entre otros; y en fuentes primarias de recolección de información necesarias para laaplicación de cuestionarios a personas clave pertenecientes a empresas del sector agroalimentario del estado Zulia. Se concluye que las estrategias de reorganización de procesos se limitan a mejoras graduales en los procesos de producción medulares, incorporando tecnología o simplemente etapas en las que adicionan valor a los productos finales; mientras que las dirigidas a los productos se emprenden con el fin de: 1 que los consumidores de más escasos recursos puedan accesar a los productos por el menor precio de los mismos dado su menor tamaño, manteniendo lealtad de marca y, 2 agregar valor a los productos finales, con la consecuencia implícita de costos adicionales.

  3. O uso do plasma rico em plaquetas associado ao aspirado de medular óssea na osteotomia tibial tipo puddu The use of platelet rich plasma enriched with bone marrow aspirate in puddu tibial osteotomy

    Directory of Open Access Journals (Sweden)

    Caio Oliveira D'Elia

    2009-01-01

    Full Text Available OBJETIVO: O presente estudo procurou avaliar a aplicação do plasma rico em plaquetas associado ao aspirado de medular óssea como substituto ósseo ao enxerto autólogo do ilíaco nas osteotomias tibiais proximais de cunha de adição medial (OTCAM. MÉTODOS: Foram estudados 25 pacientes submetidos a OTCAM divididos de forma randomizada em dois grupos, grupo ilíaco, 14 pacientes submetidos a OTCAM nos quais se utilizou o enxerto autólogo do ilíaco para preencher o sitio da osteotomia, grupo PRP, 11 pacientes submetidos a OTCAM nos quais se utilizou um composto formado por plasma rico em plaquetas associado ao aspirado de medular ósseo para preencher o sitio da osteotomia. Foram avaliados o sangramento (variação dos níveis de hemoglobina e hematócrito e a dor (escala visual analógica -EVA, comparando os grupos em relação a essas variáveis. RESULTADOS: Não foram observadas diferenças entre os grupos no que se refere à variação dos níveis de hemoglobina (p = 0,820 e hematócrito (p = 0,323. Os grupos não foram diferentes em relação à intensidade da dor segundo a EVA (p = 0,538. CONCLUSÃO: O uso do PRP associado ao aspirado de medular óssea nas OTCAM não demonstrou vantagem sobre a utilização do enxerto autólogo do ilíaco no que se refere a dor e sangramento.OBJECTIVE: The present study was performed in order to evaluate the use of platelet rich plasma associated to bone marrow aspirate, substituting autologous iliac bone graft in medial opening wedge osteotomy (OWHTO. METHODS: Twenty-five patients were submitted to tibial opening wedge osteotomy, being divided into two groups. Iliac group: 14 patients submitted to OWHTO, using autologous iliac bone graft to fill the gap. PRP group: 11 patients using platelet rich plasma associated to bone marrow aspirate to fill the gap. We evaluated bleeding (hemoglobin and hematocrit levels and pain (visual analogic scale-VAS, then we compared the groups regarding these variables

  4. Giant basal cell carcinoma Carcinoma basocelular gigante

    OpenAIRE

    Nilton Nasser; Nilton Nasser Filho; Bruno Trauczynski Neto; Lissandra Melati da Silva

    2012-01-01

    The basal cell carcinoma is the most common skin cancer but the giant vegetating basal cell carcinoma reaches less than 0.5 % of all basal cell carcinoma types. The Giant BCC, defined as a lesion with more than 5 cm at its largest diameter, is a rare form of BCC and commonly occurs on the trunk. This patient, male, 42 years old presents a Giant Basal Cell Carcinoma which reaches 180 cm2 on the right shoulder and was negligent in looking for treatment. Surgical treatment was performed and no s...

  5. Liver cancer - hepatocellular carcinoma

    Science.gov (United States)

    Primary liver cell carcinoma; Tumor - liver; Cancer - liver; Hepatoma ... Hepatocellular carcinoma accounts for most liver cancers. This type of cancer occurs more often in men than women. It is usually diagnosed in people age 50 or ...

  6. Liver cancer - hepatocellular carcinoma

    Science.gov (United States)

    Primary liver cell carcinoma; Tumor - liver; Cancer - liver; Hepatoma ... Hepatocellular carcinoma accounts for most liver cancers. This type of cancer occurs more often in men than women. It is usually diagnosed in people age 50 or older. ...

  7. Undifferentiated salivary gland carcinomas

    DEFF Research Database (Denmark)

    Herbst, H.; Hamilton-Dutoit, S.; Jakel, K.T.;

    2004-01-01

    Undifferentiated salivary gland carcinomas may be divided into small cell and large cell types. Among large cell undifferentiated carcinomas, lymphoepithelial carcinomas have to be distinguished, the latter of which are endemic in the Arctic regions and southern China where virtually all cases of...... these tumors are associated with the Epstein-Barr virus (EBV). Association with EBV may also be observed in sporadic cases, and detection of EBV gene products may aid their diagnosis. Immunohistology may be employed to resolve the differential diagnosis of undifferentiated salivary gland carcinomas......, comprising malignant lymphomas, amelanotic melanomas, Merkel cell carcinomas, and adenoid cystic carcinomas, in particular in small biopsy materials. Because of the rarity of undifferentiated salivary gland carcinomas, the differential diagnosis should always include metastases of undifferentiated carcinomas...

  8. Utilidad del estudio de pérdidas de heterocigosidad en los genes p53, p16 y APC en muestras de cavidad oral como marcadores de riesgo para carcinoma broncogenético

    OpenAIRE

    Roig Vázquez, Francisco

    2011-01-01

    El objetivo principal de la tesis es estudiar la utilidad de la deteccion de perdidas de heterocigosidad (PDH) en los locus cromosómicos 17p13, 9p21 y 5q21, sobre muestras de material citológico exfoliado de cavidad oral, como factor pronóstico de carcinoma broncogénico.

  9. Hepatocellular carcinoma.

    Science.gov (United States)

    Llovet, Josep M; Zucman-Rossi, Jessica; Pikarsky, Eli; Sangro, Bruno; Schwartz, Myron; Sherman, Morris; Gores, Gregory

    2016-01-01

    Liver cancer is the second leading cause of cancer-related deaths globally and has an incidence of approximately 850,000 new cases per year. Hepatocellular carcinoma (HCC) represents approximately 90% of all cases of primary liver cancer. The main risk factors for developing HCC are well known and include hepatitis B and C virus infection, alcohol intake and ingestion of the fungal metabolite aflatoxin B1. Additional risk factors such as non-alcoholic steatohepatitis are also emerging. Advances in the understanding of the molecular pathogenesis of HCC have led to identification of critical driver mutations; however, the most prevalent of these are not yet druggable targets. The molecular classification of HCC is not established, and the Barcelona Clinic Liver Cancer staging classification is the main clinical algorithm for the stratification of patients according to prognosis and treatment allocation. Surveillance programmes enable the detection of early-stage tumours that are amenable to curative therapies - resection, liver transplantation or local ablation. At more developed stages, only chemoembolization (for intermediate HCC) and sorafenib (for advanced HCC) have shown survival benefits. There are major unmet needs in HCC management that might be addressed through the discovery of new therapies and their combinations for use in the adjuvant setting and for intermediate- and advanced-stage disease. Moreover, biomarkers for therapy stratification, patient-tailored strategies targeting driver mutations and/or activating signalling cascades, and validated measurements of quality of life are needed. Recent failures in the testing of systemic drugs for intermediate and advanced stages have indicated a need to refine trial designs and to define novel approaches. PMID:27158749

  10. Hepatocellular carcinoma.

    Science.gov (United States)

    Edwards, J T; Macdonald, G A

    2000-05-01

    The incidence of hepatocellular carcinoma (HCC) appears to be declining in Taiwan and potentially in other high-prevalence areas as a consequence of vaccination for hepatitis B virus (HBV). However, there is evidence that the incidence of HCC is increasing in North America and Europe. This appears to be related to the increasing prevalence and duration of hepatitis C virus (HCV) infection in these countries. There is also growing evidence to support an increase in the risk of HCC in patients with HCV who are coinfected with occult HBV (patients who have lost HBV surface antigen but still have detectable HBV DNA either in blood or liver). Occult HBV infection in patients with HCV may be more common than previously thought, and HCC that occurs in this setting appears to have a worse prognosis. There is continuing interest in the effect of interferon therapy on the incidence of HCC in patients with HCV. Several studies from Japan have shown a benefit in patients without cirrhosis, although there are a number of potentially confounding variables that may partly explain these results. Prospective randomized studies are needed to investigate this important question. The molecular biology of HCC and the events of malignant transformation in the liver continue to be areas of intense study. Recently, there has been considerable interest in telomeres, the repeat units on the ends of chromosomes, and the enzyme that maintains these, telomerase. Telomeres shorten with each cell division and can be used to determine the number of divisions a cell has undergone. Eventually they reach a critical length, with further loss resulting in cellular senescence. Telomerase restores telomere length and may help malignant cells escape senescence. Nearly all HCCs have telomerase activity and assessments of telomeres and telomerase may be clinically useful. PMID:17023886

  11. Cryotherapy for hepatocellular carcinoma

    DEFF Research Database (Denmark)

    Awad, Tahany; Thorlund, Kristian; Gluud, Christian

    2009-01-01

    BACKGROUND: Hepatocellular carcinoma is the most common primary malignant cancer of the liver. Evidence for the role of cryotherapy in the treatment of hepatocellular carcinoma is controversial. OBJECTIVES: The aim of this review is to evaluate the potential benefits and harms of cryotherapy for...... the treatment of hepatocellular carcinoma. SEARCH STRATEGY: We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, and LILACS until June 2009. We identified further studies by...... hepatocellular carcinoma. Randomised clinical trials with low-risk of bias may help in defining the role of cryotherapy in the treatment of hepatocellular carcinoma....

  12. Basal cell carcinoma of the skin with areas of squamous cell carcinoma: a basosquamous cell carcinoma?

    OpenAIRE

    Faria, J.

    1985-01-01

    The diagnosis of basosquamous cell carcinoma is controversial. A review of cases of basal cell carcinoma showed 23 cases that had conspicuous areas of squamous cell carcinoma. This was distinguished from squamous differentiation and keratotic basal cell carcinoma by a comparative study of 40 cases of compact lobular and 40 cases of keratotic basal cell carcinoma. Areas of intermediate tumour differentiation between basal cell and squamous cell carcinoma were found. Basal cell carcinomas with ...

  13. Carcinoma hepatocelular metastático em Jaguatirica (Leopardus pardalis

    Directory of Open Access Journals (Sweden)

    Dayane F.H. Miranda

    2015-11-01

    Full Text Available RESUMO: O carcinoma hepatocelular (CHC é uma neoplasia rara nos animais domésticos e em espécies selvagens foi relatado somente em antílopes, veado, cães da pradaria e furões, mas não existem relatos em Leopardus pardalis (jaguatirica. Este trabalho descreve um caso de carcinoma hepatocelular metastático em uma fêmea felina de aproximadamente 18 anos de idade, da espécie Leopardus pardalis, proveniente do Parque Zoobotânico de Teresina-PI, com histórico de anorexia, apatia e evolução ao óbito que foi encaminhada ao Setor de Patologia Animal da Universidade Federal do Piauí para exame anatomopatológico. À necropsia foram observadas duas nodulações de aproximadamente 8,0cm de diâmetro no fígado, de coloração variando da brancacenta ao vermelhado claro, amarelada a vermelho escuro, subdivididas em lóbulos por tecido conjuntivo. No pâncreas foram observadas múltiplas nodulações de aproximadamente 1,0 cm de diâmetro, com superfície lisa, consistência firme, coloração vermelho-amarelada. A superfície de corte dos rins também apresentava várias nodulações milimétricas de distribuição multifocal, na região córtico-medular, consistência firme, coloração branco-acinzentada ou amarelada, sugerindo metástase. Os fragmentos das lesões de fígado foram coletados e no exame microscópico observaram-se proliferação de hepatócitos em cordões bem diferenciados, formando trabéculas com espessura de três ou mais células. Os hepatócitos apresentavam-se volumosos, pleomórficos, com citoplasma eosinofílico. Na coloração com PAS constataram-se, regularmente, acúmulo de glicogênio nos hepatócitos neoplásicos. A confirmação foi feita pela técnica de imunoistoquímica, utilizando-se anticorpo monoclonal (Hepatocyte Specific Antigen. Os achados anatomohistopatológicos, e o auxilio da imunoistoquímica permitiram concluir pelo diagnóstico de hepatocarcinoma trabecular metastático em Leopardus pardalis

  14. Synchronous gastric neuroendocrine carcinoma and hepatocellular carcinoma

    DEFF Research Database (Denmark)

    Ewertsen, Caroline; Henriksen, Birthe Merete; Hansen, Carsten Palnæs;

    2009-01-01

    UNLABELLED: Gastric neuroendocrine carcinomas (NECs) are rare tumours that are divided into four subtypes depending on tumour characteristics. Patients with NECs are known to have an increased risk of synchronous and metachronous cancers mainly located in the gastrointestinal tract. A case of...... synchronous gastric NEC and hepatocellular carcinoma in a patient with several other precancerous lesions is presented. The patient had anaemia, and a gastric tumour and two duodenal polyps were identified on upper endoscopy. A CT scan of the abdomen revealed several lesions in the liver. The lesions were...... invisible on B-mode sonography and real-time sonography fused with CT was used to identify and biopsy one of the lesions. Histology showed hepatocellular carcinoma. A literature search showed that only one case of a hepatocellular carcinoma synchronous with a gastric NEC has been reported previously. TRIAL...

  15. Carcinoma tricofolicular con capacidad metastásica

    Directory of Open Access Journals (Sweden)

    C.B. Pinilla-Martínez

    2015-03-01

    Full Text Available El carcinoma folicular es un tumor maligno derivado del folículo piloso. La mayor parte de los tumores foliculares son benignos, pero en los últimos años se han publicado casos aislados de tumores anexiales con características de malignidad y con una gran agresividad local siendo en principio tumores que se consideraban benignos. Creemos que este tumor está siendo infradiagnosticado, y como consecuencia, infratratado al ser confundido con otros tumores malignos originados en la piel, como el carcinoma basocelular y sobre todo con el carcinoma epidermoide, en parte por poca documentación y por la dificultad para su diagnóstico anatomopatológico. Presentamos un caso de carcinoma tricofolicular en cuero cabelludo en una mujer de 51 años de edad que rápidamente invade sistema nervioso central y que en solo 3 meses metastatiza a pulmón.

  16. Estimulación eléctrica medular en pacientes con dolor crónico: evaluación de la discapacidad y la calidad de vida Spinal cord stimulation in patients with chronic pain: disability and quality of life evaluation

    Directory of Open Access Journals (Sweden)

    A. Jiménez-Ramos

    2010-04-01

    Full Text Available Introducción: La estimulación eléctrica medular (EEM definitiva es un procedimiento para pacientes con dolor crónico de predominio neuropático. El objetivo fue analizar la respuesta a la EEM en el dolor y los índices de calidad de vida. Material y métodos: Se trata de un estudio de serie de pacientes retrospectiva, longitudinal y descriptiva, en el que se incluyó a 40 pacientes de ambos sexos, con edades entre los 18 y los 85 años, a los que se implantó un sistema de EEM. Se evaluó la intensidad del dolor mediante la escala visual analógica (EVA previamente, al mes y a los 6 meses de implantado. Se aplicó el índice de discapacidad de Oswestry y el Fast-Espiditest previo a la implantación y a los 6 meses. Se utilizó estadística descriptiva, con prueba de ANOVA, para lo que se consideró como significativo un valor de p Introduction: Spinal Cord Stimulation (SCS is a procedure for patients with chronic intractable pain of neuropathic predominance. The objective was to evaluate the disability and quality of life in patients with SCS. Material and methods: A retrospective, descriptive and longitudinal research study with 40 male and female patients from 30 to 70 years of age with a SCS system. The intensity of pain was assessed by means of Visual Analogue Scale (VAS, 1 month before and at 6 months after the implant. The Oswestry and the Fast-Espiditest disability indexes were used before and 6 months after the implantation. The statistical analysis of the results was performed using the ANOVA test using a p < 0.05 as significant. Results: A total of 88% of patients had neuropathic pain with an aetiological diagnosis of failed back surgery syndrome (67.5%. The baseline VAS score was 8.8 ± 1.1, at 1 month 3.5 ± 2.3 and 3.9 ± 2.0 at the 6th month (p < 0.001. The initial Oswestry Index was 65.5 ± 8.5 and the final one 43.8 ± 11.4 (p < 0.001. Using the Fast-Espiditest 10% of patients had moderate pain and 90% had intense pain at

  17. Metachronous colorectal carcinoma

    DEFF Research Database (Denmark)

    Bülow, Steffen; Svendsen, L B; Mellemgaard, A

    1990-01-01

    During the period 1943-67, 903 Danish patients aged less than 40 years had colorectal carcinoma. The patients were followed up for up to 41 years and during this period 44 of 501 (9 per cent) operated on for cure developed a metachronous colorectal carcinoma. The cumulative risk of a metachronous...... colorectal carcinoma was 30 per cent after up to 41 years of observation. The occurrence of a metachronous colorectal carcinoma was evenly distributed in the observation period. The cumulative survival rate after operation for a metachronous colorectal carcinoma was 41 per cent after 20 years of observation....... We propose a lifelong follow-up programme after resection of colorectal carcinoma for cure in this age group, including annual Hemoccult test and colonoscopy at 3-year intervals....

  18. URACHAL CARCINOMA IN BLADDER

    Institute of Scientific and Technical Information of China (English)

    薛丽燕; 吕宁; 何祖根; 林冬梅; 刘秀云

    2004-01-01

    Objective: To investigate the clinicopathologic features and diagnostic criteria of urachal carcinoma in the bladder.Methods: Seven cases of urachal carcinoma in the bladder were analyzed retrospectively. Results: All the tumors were found locating in the dome of bladder. Of them, 4 were mucinous adenocarcinoma, one was well differentiated papillary enteric adenocarcinoma, one was well differentiated squamous carcinoma, and one was neuroendocrine carcinoma. Cystomorphous urachal remnants were found in 4 cases. The main complaint was hematuria and all patients underwent partial excision of bladder and urachus. Conclusion: Mucinous adenocarcinoma is the main histo-pathological type, and cystomorphous urachal remnants are often accompanied with urachal carcinoma in the bladder. The key diagnostic criteria of urachal carcinoma in bladder are site and histopathology. And to examine the specimens carefully to find the urachal remnants is important.

  19. Noninvasive determination of inspiratory pressure in patients with spinal cord injury: what is the best method? Determinação não-invasiva da pressão inspiratória em pacientes com lesão medular traumática: qual é o melhor método?

    Directory of Open Access Journals (Sweden)

    Andrea Ponte Rocha

    2009-03-01

    Full Text Available The aim of the study was to evaluate the performance of sniff nasal inspiratory pressure (SNIP and MIP in individuals with spinal cord injury. We evaluated 26 patients with spinal cord injury. Mean FVC in those with tetraplegia was 52 ± 19% of predicted, compared with 78 ± 23% of predicted in those with paraplegia (p O objetivo deste estudo foi verificar o desempenho da pressão inspiratória nasal durante o fungar (PInas e da PImáx em indivíduos com lesão medular traumática. Foram avaliados 26 pacientes com lesão medular traumática. Os pacientes tetraplégicos e paraplégicos exibiram diferentes médias do percentual do previsto da CVF, respectivamente, 52 ± 19% e 78 ± 23% (p < 0,05. Ao contrário da PImáx, o percentual do previsto médio da PInas foi inferior nos tetraplégicos (p < 0,05 e, em todos os participantes, a correlação com o nível da lesão foi significativa (r = 0,489; IC95%: 0,125-0,737. O impacto do melhor discernimento da PInas no diagnóstico das alterações da função inspiratória de pacientes com lesão medular traumática merece ser aprofundado.

  20. Enfermedad navicular con desviación axial del hueso navicular en una yegua de 33 meses de edad

    Directory of Open Access Journals (Sweden)

    Jaime Alvarez P

    2010-04-01

    Full Text Available Se describe un caso de enfermedad navicular con desviación vertical del eje longitudinal del hueso navicular en una yegua de trocha pura, de 33 meses de edad, procedente del municipio de Montería (Córdoba, Colombia, a la cual se le detectó signos de cojera intermitente en el miembro posterior derecho con apoyo en lumbres, punteo constante y en abducción, aumento de volumen en el bulbo lateral de dicho miembro, marcado dolor al paso. A la palpación se determino sensibilidad en la parte posterior (bulbos y talones del casco derecho, prueba de flexión de nudo positiva en los miembros posteriores, más marcado en el derecho, por lo que se le realizó radiología del pie y del sistema podotroclear, detectando lisis de la corteza flexora y pérdida de la diferenciación cortico-medular con desviación axial del hueso navicular. Estos hallazgos clínicos y radiológicos obedecen principalmente a enfermedad navicular. Esta patología es también conocida en equinos como síndrome navicular, la cual es una enfermedad crónica, degenerativa y progresiva, caracterizada por afectar al hueso navicular, bursa navicular o superficies adyacentes al tendón flexor digital profundo. Se realizo tratamiento farmacológico que permitió la recuperación total del paciente.

  1. Del Piero

    OpenAIRE

    Umbaca, Enzo

    2015-01-01

    Rifacendosi al “Pinturicchio”, epiteto con cui Gianni Agnelli consacrava il calciatore Alessandro Del Piero un “artista del calcio”, Enzo Umbaca scrisse al popolare personaggio invitandolo a collaborare ad una performance durante la quale Pinturicchio-Del Piero avrebbe affrescato il muro di una galleria torinese calciando un pallone macchiato di grafite contro un muro sul quale è appesa la copia di un opera del Pinturicchio.

  2. Carcinoma primario intraóseo

    Directory of Open Access Journals (Sweden)

    Susana Szlabi

    2013-12-01

    Full Text Available El carcinoma primario intraóseo (PIOC es un tumor poco frecuente, definido como carcinoma escamoso que se desarrolla en huesos maxilares, no teniendo conexión inicial con mucosa ni piel adyacente. Es localmente agresivo, con una incidencia de metástasis en ganglios regionales del 28% y en pulmón del 5%, en el momento del diagnóstico. Su origen puede ser de novo o a partir de otros tumores odontogénicos. Los huesos maxilares son los únicos que tienen en su interior tejidos epiteliales, por lo cual esta neoplasia se localiza exclusivamente en este sitio, predominantemente en la mandíbula. Los criterios diagnósticos del PIOC incluyen: histopatología de carcinoma escamocelular, ausencia de compromiso de mucosa oral y senos paranasales, descartando metástasis de un sitio distante en base a estudios clínicos y métodos complementarios. El tratamiento de elección consiste, siempre que sea posible, en la exéresis con criterios oncológicos, y radio y/o quimioterapia adicional. Se requiere además, cirugía reconstructiva con injerto y/o prótesis con fines estéticos y funcionales. Presentamos el caso de un varón de 72 años, que consultó por molestias en maxilar inferior tres meses después de la extracción de un molar. Se efectuó biopsia por curetaje y luego se resecó el maxilar inferior con vaciamiento ganglionar. El estudio histopatológico mostró un carcinoma escamoso pobremente diferenciado, infiltrante en hueso maxilar, con hallazgos morfológicos que lo vinculaban a quiste odontogénico residual, y metástasis en 15 de 48 ganglios aislados. Se realizó radioterapia postquirúrgica, falleciendo a los 30 meses del diagnóstico por deterioro progresivo.

  3. CARCINOMA HEPATOCELULAR CANINO: REPORTE DE UN CASO

    Directory of Open Access Journals (Sweden)

    Edwin Buriticá G

    2009-08-01

    Full Text Available Objetivo Presentar el caso de un paciente canino, con enfermedad hepática, asociada a carcinoma hepatocelular. Materiales y métodos Fue estudiado el caso de un paciente canino de raza Pitt bull de 10 años de edad, al que se le encontraron múltiples nódulos distribuidos en todo el parénquima hepático, con diagnostico histopatológico de carcinoma hepatocelular. Resultados Se expone el caso clínico de un paciente canino de raza Pitt bull, que es presentado a consulta externa por presentar decaimiento y distensión abdominal, una vez realizado el examen físico sistemático se evidenció hepatomegalia y un crecimiento anormal hacia la región del mesogastrio derecho. Los exámenes paraclinicos e histopatológicos demostraron la presencia de enfermedad hepática asociada a carcinoma hepatocelular. Conclusiones El carcinoma hepatocelular es una entidad de rara presentación, clínicamente cursa con signos muy similares a otras alteraciones tumorales de compromiso hepático, su diagnostico suele ser histopatológico.

  4. Avaliação clínica e por ressonância magnética do ombro de pacientes lesados medulares Clinical assessment and magnetic resonance imaging of the shoulder of patients with spinal cord injury

    Directory of Open Access Journals (Sweden)

    Alex Pereira Alves

    2012-01-01

    Full Text Available OBJETIVO: Estudar o ombro destes indivíduos através de ressonância magnética para detectar lesões clínicas ou subclínicas para instituir programas específicos de reabilitação. MÉTODOS: Foram avaliados nove pacientes lesados medulares, com seguimento no Laboratório de Biomecânica e Reabilitação do Aparelho Locomotor HC/UNICAMP. Foram divididos em dois grupos de acordo com a presença de paraplegia ou tetraplegia e avaliados através de anamnese e exame físico para correlação com o exame de imagem. RESULTADOS: 41% dos ombros avaliados com imagens de ressonância apresentaram resultado normal. Dentre os resultados alterados, a tendinopatia do supra-espinhal e a degeneração acrômio-clavicular foram às alterações mais encontradas e 80% dos ombros com exame alterado possuiam mais de uma lesão associada. CONCLUSÃO: Pela amostra do estudo é possível identificar uma etiologia multivariada da omalgia, com particularidades para indivíduos paraplégicos e tetraplégicos. A inclusão rotineira da avaliação clínica e radiológica do ombro nos indivíduos lesados medulares pode contribuir para a evolução das técnicas de reabilitação e redução tanto das lesões músculo-articulares quanto dos sintomas álgicos. Nível de Evidência II, Desenvolvimento de critérios diagnósticos em pacientes consecutivos com padrão de referência "ouro" aplicado.OBJECTIVE: To study the shoulder of this group of patients using magnetic resonance imaging to detect clinical and subclinical disorders and establish a rehabilitation program. METHODS: Nine patients with spinal cord injury followed in the Laboratory of Biomechanics and Rehabilitation of the Locomotive System at HC/UNICAMP were divided into two groups according to the presence of paraplegia and tetraplegia and were clinically assessed for correlation with the imaging exams. RESULTS: Normal results were found in 41% of the shoulders. Most common injuries were tendinopathy of the

  5. Avaliação funcional e histológica da oxigenoterapia hiperbárica em ratos com lesão medular Functional and histologic evaluation of hyperbaric oxygen therapy in rats with spinal cord injury

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo de Carvalho Galvão

    2011-01-01

    Full Text Available OBJETIVOS: Avaliar a eficácia da aplicação da oxigenoterapia hiperbárica em ratos Wistar, com lesão medular contusa produzida por equipamento computadorizado para impacto por queda de peso, NYU Impactor. MÉTODOS: Avaliaram-se 17 ratos machos com peso variando de 265 a 426 g; realizaram-se impactos com peso de 10 g de uma altura pré-determinada de 12,5 mm ao nível da décima vértebra torácica, após realização de laminectomia prévia. Os ratos foram divididos aleatoriamente em grupo controle e grupo oxigênio hiperbárico. Este último, submetido à tratamento com oxigenoterapia em câmara hiperbárica, durante uma hora diária por um período de 30 dias. A avaliação da recuperação locomotora foi realizada no 2º, 9º, 16º, 23º e 30º dia pós-operatório, avaliados através de escala funcional e o sítio de lesão submetido à exame anatomopatológico. RESULTADOS: Demonstrou-se melhora da recuperação locomotora nos ratos tratados com oxigênio hiperbárico nas fases iniciais de avaliação mas no final da avaliação não havia diferença estatisticamente significante entre ambos grupos. O exame anatomopatológico comprovou as alterações estruturais da medula espinal nos dois grupos. CONCLUSÃO: A lesão medular leve provocada nos ratos evoluiu de maneira diferente no grupo da oxigenoterapia hiperbárica comparativamente ao grupo controle, na fase inicial.OBJECTIVE: To evaluate the effectiveness of the application of hyperbaric oxygen therapy in Wistar rats with spinal cord contusion produced using computerized equipment to create impact by a falling weight, NYU Impactor. METHODS: We evaluated 17 male rats with weights ranging from 265 to 426 g; impacts were performed with a weight of 10 g from a pre-determined height of 12.5 mm, at the tenth thoracic vertebra, after completion of prior laminectomy. The rats were randomly divided into a control group and a group treated with hyperbaric oxygen. The latter, was treated with

  6. A ação do decanoato de nandrolona (Deca-durabolin®) sobre parâmetros hematológicos e proteína total plasmática de ratos (Rattus rattus) com depressão medular induzida após administração de sulfato de vincristina (Oncovin®)

    OpenAIRE

    Perez Regina Raquel; Silva Maria Adriana Machado Lobo e; Varzim Fernanda Leme Silva Bastos; Oliveira Sylvia Bonci de; Hucke Érica Teixeira

    2005-01-01

    É comum o clínico veterinário submeter animais à quimioterapia para controle de neoplasias e observar depressão medular, com presença de anemia, leucopenia e trombocitopenia como efeitos colaterais. Nesses casos, podem-se adotar duas condutas: supressão da quimioterapia e/ou utilização de estimulantes de medula óssea. Dentre os medicamentos estimulantes mais utilizados, podemos citar o decanoato de nandrolona (Deca-durabolin®), cuja eficácia para os animais domésticos é pouco estudada, com po...

  7. Análise clínica e ultrassonográfica dos ombros de pacientes lesados medulares em programa de reabilitação Shoulders of patients with spinal cord injuriessubmited to rehabilitation program - a clinical and ultrasound-based assessment

    OpenAIRE

    André Felipe Ninomyia; Carolina Luísa Martins de Jesus; Leandro Luis Auletta; Carolina de Medeiros Rimkus; Daniel Miranda Ferreira; Américo Zoppi Filho; Alberto Cliquet Junior

    2007-01-01

    O aumento da incidência de traumas de alta energia esta relacionado com o crescimento da prevalência de lesões raquimedulares ocasionando seqüelas motoras nos membros. O programa de reabilitação proporciona perspectiva de melhora da qualidade de vida, colaborando para a reintegração social desses indivíduos. As síndromes dolorosas dos ombros são freqüentes nos pacientes lesados medulares, independentemente do programa de reabilitação adotado. No presente estudo, avaliou-se por meio da ultrass...

  8. Carcinoma en quiste tirogloso Carcinoma in thyroglosal duct cyst

    Directory of Open Access Journals (Sweden)

    M.E. Storani

    2010-09-01

    Full Text Available El carcinoma diferenciado de tiroides en quiste tirogloso (CaQT es una rara entidad. En diferentes series de pacientes operados por quistes tiroglosos su incidencia fue del 0.7 al 1.07%. Luego de la extirpación del quiste por el procedimiento de Sistrunk, no hay consenso sobre la indicación de tiroidectomía total, radioablación y/o terapéutica supresiva con levotiroxina. El objetivo del Departamento de tiroides de SAEM, fue evaluar: formas de presentación, evolución clínica, métodos diagnósticos de utilidad y tratamiento para consensuar futuras conductas. Material y Métodos: Estudio multicéntrico, retrospectivo en 22 pacientes entre 10 a 69 años, 15 mujeres y 7 varones. Resultados: El tamaño de los quistes osciló entre 1 y 8 cm (Mediana= 3.0 cm, Χ ± DS= 3.7 ± 2.2 cm. La mitad de los pacientes presentó crecimiento del quiste en los 6 meses previos a la cirugía. La punción resultó sospechosa en 2/5 quistes y positiva en uno. La ecografía tiroidea evidenció nódulos en 4/13 casos (30%. Se realizó tiroidectomía en 17/22 pacientes (total: 15 y subtotal: 2. La histología del CaQT demostró carcinoma papilar en 21 y carcinoma folicular en uno. Hubo coexistencia de cáncer intratiroideo en el 23.5% de los casos, ninguno multicéntrico. Dos pacientes presentaron metástasis ganglionares y otro tuvo compromiso muscular (ninguno de ellos coexistió con cáncer intratiroideo. Se radioablacionó a 13 pacientes. En 9/11 pacientes la tiroglobulina permaneció indetectable durante el seguimiento (1 a 14 años. Conclusiones: 1 Realizar ecografía de cuello y punción ecoguiada a todo paciente con quiste tirogloso. 2 En caso de CaQT combinar simultáneamente tiroidectomía total y procedimiento de Sistrunk. 3 Evaluar radioablación complementaria y tratamiento supresivo con levotiroxina en cada caso. 4 Efectuar el seguimiento tal como en los carcinomas ortotópicos.Differentiated thyroid carcinoma (DTC in thyroglosal duct cyst (TGDC is

  9. Recursos fisioterapêuticos na prevenção da perda da densidade mineral óssea com lesão medular Physiotherapy resources on bone mineral density loss prevention in patients with spinal cord injuries

    Directory of Open Access Journals (Sweden)

    Daniele Rodrigues

    2004-09-01

    Full Text Available Este trabalho é uma revisão bibliográfica sobre os tratamentos fisioterápicos destinados a prevenção, estabilização ou lentificação da perda da densidade mineral óssea em pacientes portadores de lesão medular. Foram encontrados poucos trabalhos que se destinaram aos tratamentos fisioterápicos para desmineralização óssea. Em relação aos tipos de tratamentos encontrados foram: estimulação elétrica funcional, estimulação elétrica funcional com bicicleta ergométrica, ortostatismo e deambulação. Estes tratamentos são bastante questionáveis não tendo um consenso na metodologia, apresentando muitas controvérsias em relação à eficácia dos tratamentos, que serão discutidos no decorrer deste trabalho.This work is bibliographic review about the physiotherapy treatments for the attenuation, prevention and stabilization or slowing down of the bone mineral density loss in spinal cord injured patients. There are few studies focusing the efficiency the physiotherapy treatment for bone demineralization. The kinds of treatments found were: functional electrical stimulation, functional electrical stimulation with an bycicle ergometry, orthostatic and deambulation. These treatments are much questionable, and with no consensus on the methodology, with the lot of controversies in relation to the efficacy of the treatments, which are going to be discussed in the development of this study.

  10. CARACTERIZACIÓN ANATÓMICA DEL DESARROLLO DE LA RAÍZ RESERVANTE DE CAMOTES PERUANOS (IPOMOEA BATATAS (L. LAM., CONVOLVULACEAE

    Directory of Open Access Journals (Sweden)

    M. Marín

    2014-06-01

    Full Text Available La caracterización anatómica del desarrollo de la raíz reservante fue llevada a cabo en tres genotipos de camotes. En los estadios iniciales se encontraron diferencias en el desarrollo del xilema primario, incluyendo la formación de un parénquima medular. La actividad cambial secundaria contribuyó en gran medida al desarrollo del parénquima reservante, determinando un arreglo diferencial de los haces vasculares. Así mismo, fueron hallados granos simples y compuestos de almidón, siendo las dimensiones de los primeros asociadas a las mayores dimensiones celulares del parénquima. Uno de los genotipos evaluados presentó altos valores en el espesor del súber y granos de almidón (123,9 µm y 29,5 µm respectivamente. Se sugiere usar estas características como parámetros en la selección de genotipos de camote.

  11. Epidermoid carcinoma of the conjunctiva. Case report

    Directory of Open Access Journals (Sweden)

    María Adela LLull Tombo

    2011-12-01

    Full Text Available Se presenta el caso de un paciente de 76 años de edad con un carcinoma epidermoide de conjuntiva.  La manifestación clínica principal fue la molestia, el dolor y el ojo rojo. Al examen físico ocular se encontró lesión blanquecina, con vasos sanguíneos en el ángulo interno, por encima del pterigion en ojo derecho. Se diagnosticó como carcinoma epidermoide de la conjuntiva, el cual evolucionó de forma rápida e invasiva. Se intervino quirúrgicamente en tres ocasiones debido a las recurrencias.

  12. Avaliação funcional de pessoas com lesão medular: utilização da escala de independência funcional - MIF

    Directory of Open Access Journals (Sweden)

    Gelson Aguiar da Silva

    2012-01-01

    Full Text Available La lesión de la médula espinal generalmente tiene el traumatismo como causa, originando serias molestias en el individuo, su familia, y sociedad. Es grave problema de salud pública. El objetivo de este trabajo fue investigar la ganancia funcional para personas con paraplejia traumática, participantes de un programa de rehabilitación, a través de la aplicación de la Escala de Medida de Independencia Funcional. Se trata de un estudio transversal retrospectivo, cuantitativo y descriptivo, con análisis de 228 registros. Se utilizó el programa Statistical Package for Social Science, versión 13 para Windows, con determinadas pruebas estadísticas. Los resultados muestran que la ganancia funcional promedio se produjo en todas las categorías de cuidado del cuerpo, control de esfínteres, traslado, caminar y escaleras. De este estudio se concluye que la rehabilitación promueve mejoras en la independencia funcional es fundamental para la recuperación y la independencia para las personas con lesión de la médula espinal.

  13. Multiple primary bronchogenic carcinomas.

    Science.gov (United States)

    Yang, X; Ji, H; Paljarvi, L; Soimakallio, S

    1996-07-01

    Multiple primary bronchogenic carcinomas (MPBCa) are extremely rare. The differentiation of a MPBCa from a pulmonary metastasis due to an extrathoracic neoplasm is sometimes difficult. We reviewed 324 pathologically proved primary pulmonary carcinomas and found six cases of MPBCa (1.9%). We herewith present the series and discuss the diagnosis of MPBCa. PMID:21594435

  14. Primary cutaneous myoepithelial carcinoma

    DEFF Research Database (Denmark)

    Frost, Markus Winther; Steiniche, Torben; Damsgaard, Tine Engberg;

    2013-01-01

    This study describes a case of primary myoepithelial carcinoma of the skin and reviews the available literature on this topic. Myoepitheliomas and carcinomas arise most frequently from myoepithelial cells within the salivary glands but are found in many anatomical locations. We documented a case of...... an 80-year-old man with a 2 × 2 × 1 cm tumour located on the scalp. This tumour emerged over a period of 2 months. The tumour was radically excised, and histological examination revealed a cutaneous myoepithelial carcinoma. At an 18-month follow-up, no recurrence of the tumour was found. A systematic...... literature search identified 23 papers that reported 58 cases of cutaneous myoepitheliomas and myoepithelial carcinomas. All cases are reviewed in the presented paper. This case report and literature review serves to increase awareness regarding myoepithelial carcinomas. These tumours exhibit high metastatic...

  15. Síndrome de carcinoma basocelular nevoide con agenesia de cuerpo calloso, mutación en PTCH1 y ausencia de carcinoma basocelular

    OpenAIRE

    Luis D Mazzuoccolo; María Florencia Martínez; Carolina Muchnik; Pablo J. Azurmendi; Fernando Stengel

    2014-01-01

    El síndrome del carcinoma basocelular nevoide (SCBCN) o de Gorlin-Goltz es un raro desorden autosómico dominante con un amplio espectro de manifestaciones clínicas. El signo cardinal es la presencia de múltiples carcinomas basocelulares (CBCs) y su ausencia demora el diagnóstico. Presentamos un adolescente de 14 años con diagnóstico de SCBCN por la presencia de queratoquistes odontogénicos, hiper­telorismo, macrocefalia y agenesia del cuerpo calloso pero sin lesiones cutáneas. La madre, de 43...

  16. Pré-condicionamento isquêmico e monitorização da função medular na abordagem da aorta torácica descendente Ischemic preconditioning and spinal cord function monitoring in the descending thoracic aorta approach

    Directory of Open Access Journals (Sweden)

    Bernardo Assumpção de Mônaco

    2007-03-01

    Full Text Available OBJETIVOS: Avaliar a eficácia do pré-condicionamento isquêmico (PI agudo, guiado por potenciais evocados somatossensoriais (PESS, como método de proteção medular em cães e analisar o valor dos PESS na monitorização da função medular. MÉTODOS: Foram utilizados 28 cães submetidos à isquemia medular obtida pelo pinçamento da aorta torácica descendente. No grupo C45, o tempo de oclusão aórtica foi de 45 min (n = 7; no grupo PI45, os cães foram submetidos ao PI antes do pinçamento aórtico por 45 min (n = 7. No grupo C60, os cães foram submetidos a 60 min de oclusão aórtica (n = 7 e no grupo PI60, os cães foram submetidos ao PI, seguido pelo pinçamento aórtico por 60 min. Os ciclos de PI foram determinados pelas alterações dos PESS. RESULTADOS: Os índices de Tarlov dos grupos pré-condicionados foram significativamente melhores que os dos grupos de controle (p = 0,005. Observou-se paraplegia em três cães do C45 e em seis do C60, enquanto todos os cães do PI45 permaneceram neurologicamente normais, assim como quatro do grupo PI60. Houve correlação entre o tempo de recuperação dos PESS após a reperfusão aórtica e o estado neurológico pós-operatório (p = 0,011, com sensibilidade e especificidade de 0,75 e 0,83, respectivamente. CONCLUSÃO: O PI agudo repetitivo, baseado na monitorização do PESS, induziu proteção à isquemia medular causada pelo pinçamento aórtico prolongado. A monitorização do PESS parece ser um bom método de detecção precoce do comprometimento isquêmico medular.OBJECTIVES: To evaluate the effectiveness of acute ischemic preconditioning (IP, based on somatosensory evoked potentials (SSEP monitoring, as a method of spinal cord protection and to asses SSEP importance in spinal cord neuromonitoring. METHODS: Twenty-eight dogs were submitted to spinal cord ischemic injury attained by descending thoracic aorta cross-clamping. In the C45 group, the aortic cross-clamping time was 45 min (n

  17. Primary subglottic carcinoma

    International Nuclear Information System (INIS)

    Primary subglottic carcinoma is rare with a uniformly poor prognosis. We present our experience of eight such cases treated over a period of ten years. One patient had a mucoepidermoid carcinoma while the rest has a squamous cell carcinoma. A combination of surgery and radiotherapy was employed in five cases, while one case underwent radiotherapy only, surgery only and salvage surgery following radical irradiation. Three cases died of locoregional failure within a year. The remaining five patients have been disease-free for six months to 3.5 years. (author). 15 refs., 1 tab

  18. Sarcomatoid renal cell carcinoma

    OpenAIRE

    Kafil Akhtar; Ahmad Shamshad; Zaheer Sufian; Mansoor Tariq

    2011-01-01

    Sarcomatoid renal cell carcinoma (SRCC) is an aggressive tumor variant thought to arise predominantly from differentiation of clear cell carcinoma. A few reports of SRCC asso-ciated with non-clear cell tumors led to the presumption that SRCC may arise from any renal cell carcinoma, although direct evidence of this is lacking. We report a case of a 70-year-old male patient, who presented with acute left upper quadrant abdominal pain and was diagnosed to have SRCC after pathological examination...

  19. Salivary gland carcinomas

    DEFF Research Database (Denmark)

    Therkildsen, M H; Andersen, L J; Christensen, M;

    1998-01-01

    The prognosis of salivary gland carcinomas is difficult to assess. Simple mucin-type carbohydrates (T and sialosyl-T antigens, Tn and sialosyl-Tn antigens) have been shown to be of value in predicting prognosis for carcinomas in other locations. We studied the prognostic significance of the...... expression of these structures in a retrospective study of 133 patients with salivary gland carcinomas, using immunohistochemistry and a panel of well-defined monoclonal antibodies (MAbs) on formalin-fixed paraffin-embedded tissues. Sialosyl-Tn, T and sialosyl-T antigens were not correlated with prognosis...

  20. El aprendizaje cooperativo, una aproximación a la tutoría entre iguales en la formación de los estudiantes de la Licenciatura en Educación Preescolar y Física del BINE

    Directory of Open Access Journals (Sweden)

    César Simoni Rosas

    2011-02-01

    Full Text Available En la actualidad, un sin fin de evaluaciones arrojan resultados poco satisfactorios en la educación básica, lo que nos mira a centrar nuestra mirada en los docentes; es así como la educación normal juega un papel esencial en la formación de una sociedad que responda a las necesidades de un mundo en constante cambio. La educación normal ha sufrido una evolución para ser considerada parte del nivel superior, sin embargo, al analizar su esencia y relevancia es imperativo reconocer que deben existir cambios medulares en las prácticas educativas de los docentes de las normales que doten a los docentes en formación de saberes basados en nuevas tendencias que no se limiten a un discurso vanguardista sino que reflexionen a partir de su trabajo cotidiano para educar a las generaciones futuras en ambientes cooperativos competentes

  1. Antitumorigenicità del D-Ribosio e KHCO3 sulla linea di carcinoma mammario umano Hs 578T ed effetti sulla linea d'epitelio mammario umano non tumorale Hs 578BST

    OpenAIRE

    Bruni, Luca

    2014-01-01

    Lo scopo del presente lavoro è quello di studiare come la proliferazione cellulare ed il potenziale migratorio-invasivo, considerati due “hallmarks” della linea cellulare tumorale Hs578T, possano venir modificati dal K:D-Rib, soluzione acquosa di KHCO3 e D-ribosio. Il K:D-Rib può essere concepito come un integratore alimentare e data la sua natura è stato da subito chiaro che lo scopo di questo studio dovesse essere una valutazione comparata degli effetti su un modello tumorale ed un non tumo...

  2. Una revisión a la teoría general del costo

    Directory of Open Access Journals (Sweden)

    Amaro Yardin

    2002-12-01

    Full Text Available El trabajo tiene como objetivo definir qué debe entenderse por una Teoría General del Costo y, en consecuencia, cuál debe ser su contenido. Se comienza por emitir algunas consideraciones sobre el concepto de "Teoría" y, complementariamente, el de "Teoría General del Costo". Se exponen consideraciones sobre la naturaleza y los objetivos de las distintas manifestaciones de la técnica contable, concretadas en la Contabilidad Patrimonial y la Contabilidad de Gestión. La parte medular del trabajo alude al modelo del costeo completo y sus características, examinando si éstas permiten que este criterio pueda ser incluido en una Teoría General del Costo. Se sostiene que el modelo del costeo completo es válido exclusivamente como apoyo a la Contabilidad de Costos, en su carácter de apéndice de la Contabilidad Patrimonial. El aporte concluye con una propuesta de revisión del estado actual de la Teoría General del Costo, sosteniendo que el modelo del costeo completo debe estar fuera del ámbito de la misma, por ser incompatible con sus objetivos.This paper aims to define what should be understood as a General Cost Theory and, consequently, what its contents should be. First, some considerations are made on the concept of "Theory" and, complementarily, the concept of "General Cost Theory". Next, the nature and objectives of the different manifestations of accounting are considered, which are concretized in Financial and Management Accounting. The central part of the article deals with the full cost method and its characteristics, examining if these allow for the inclusion of this criterion in a General Cost Theory. It is asserted that the full cost model is only valid when functioning in support to Cost Accounting, as an appendix of Financial Accounting. Finally, a review of the current state of General Cost Theory is proposed, asserting that the full cost method should not be included in its field, since it is not compatible with the

  3. Chronic inflammatory demyelinating polyradiculoneuropathy: two cases with cervical spinal cord compression Polirradiculoneuropatia desmielinizante inflamatória crônica: dois casos com síndrome de compressão medular

    Directory of Open Access Journals (Sweden)

    Marcos R.G. de Freitas

    2005-09-01

    Full Text Available Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP is a peripheral nerve disorder probably due to an immunological disturb. It evolves either in a steadily progressive or in a relapsing and fluctuating course. Weakness is mainly in the lower limbs proximally and distally. The electromyography is demyelinating. The cerebral spinal fluid protein is most of times elevated. Sometimes enlarged nerves are found. There are few cases described with spinal cord compression due to hypertrophic spinal nerve roots. Two patients (females, 66 and 67 years old with diagnosis of a long standing CIDP are described. In the first one, the evolution was characterized by remission and relapsing course. The second patient had a chronic and progressive course. These patients presented after a long evolution a cervical spinal cord compression syndrome due to hypertrophic cervical roots. Neurologists must be aware of the possibility of development of spinal cord compression by enlarged spinal roots in patients with a long standing CIDP.A polirradiculoneuropatia desmielinizante inflamatória crônica (PDIC é uma afecção dos nervos periféricos de natureza autoimune, com evolução por surtos de exacerbação e remissão ou de evolver progressivo. O acometimento motor é predominante, com fraqueza proximal e distal nos membros inferiores. A eletroneuromiografia é do tipo desmielinizante com bloqueio de condução nervosa em dois ou mais nervos. Há aumento de proteínas do líquor. Com a evolução da doença pode haver espessamento dos nervos distal e/ou proximalmente. Excepcionalmente ocorre compressão da medula espinhal em qualquer segmento por raízes próximas hipertrofiadas. Foram estudadas duas mulheres de 66 e 67 anos respectivamente com quadro de PDIC de longa evolução. A primeira tinha evolução por surtos e na segunda o evolver era progressivo. Nos dois casos o espessamento proximal dos nervos provocou síndrome de compressão medular alta

  4. ANÁLISIS RETROSPECTIVO DEL CARCINOMA CUTÁNEO TIPO BASOCELULAR Y ESCAMOCELULAR EN BOGOTÁ-COLOMBIA: EPIDEMIOLOGÍA, PREVENCIÓN Y TRATAMIENTO A retrospective analysis of basall cell and squamous cell skin carcer in Bogota, Colombia: its epidemiology, prevention and treatment

    Directory of Open Access Journals (Sweden)

    óscar Iván Barón Estrada

    2009-01-01

    Full Text Available Antecedentes. El carcinoma cutáneo no melanoma del tipo basocelular (CBC y escamocelular (CEC, tiene tasas de incidencia cercanas al 13 por ciento y es el más prevalente en la población blanca. Trae elevada morbilidad para el paciente y altos costos para el sistema de salud, y aunque es la neoplasia maligna mas frecuentemente diagnosticada, en Colombia sólo se tienen estadísticas en instituciones oncológicas, haciendo énfasis principalmente en melanomas. Entre los principales factores de riesgo se encuentra la exposición a los RUVB, tipo de piel, la radiación, el virus del papiloma humano (HPV y su tratamiento incluye medicación tópica, crioterapia, electrofulguración y cirugía. Objetivo. Analizar algunas características epidemiológicas del cáncer cutáneo (CBC - CEC en nuestro medio, estableciendo similitudes y diferencias respecto a la literatura actual. Material y métodos. En la clínica San Pedro Claver se revisaron 202 historias clínicas de pacientes con diagnóstico confirmado de CBC O CEC de 2004 a 2006 en un estudio retrospectivo de serie de casos y se analizaron las variables más comunes como el tipo de lesión, su ubicación, tamaño, patrón histológico y tratamiento. Resultados. Ingresaron en el estudio 112 pacientes, de los cuales cerca del 60 por ciento eran hombres, con una edad media de 69.5 años. El 90 por ciento de las lesiones se localizaban en cara (mejillas, párpados, nariz. Del 70 por ciento de las lesiones que correspondían a CBC el tipo histológico más frecuente fue sólido nodular y del 22 por ciento de lesiones que correspondían a CEC, el moderadamente diferenciado de célula grande fue el más común. Las lesiones tuvieron un tamaño promedio de 2 cm y los procedimientos quirúrgicos más usados fueron resección más injerto (44.1%, seguido de resección más colgajo local (23.5%. El 5 por ciento de los pacientes tenían lesiones previas y uno de cada cuatro tuvo algún tipo de reca

  5. Carcinoma of the thyroid

    International Nuclear Information System (INIS)

    The natural history and the clinical findings in 227 patients with thyroid carcinoma are described and the etiology discussed. The need for uniform pathologic classification and staging is emphasized. (Auth.)

  6. Merkel Cell Carcinoma

    Science.gov (United States)

    ... of the Year Award Arnold P. Gold Foundation Humanism in Medicine Award Diversity Mentorship Program Eugene Van ... 300 PUVA treatments. What causes Merkel cell carcinoma? Scientists are still studying what causes this skin cancer. ...

  7. MEDULLARY THYROID CARCINOMA

    OpenAIRE

    V S Medvedev; P. A. Isayev; Ilyin, A. A.; D. Yu. Semin; V. V. Polkin; D. N. Derbugov; S. V. Vasilkov

    2013-01-01

    Medullary thyroid carcinoma belongs to orphan diseases affecting a small part of the population. Multicenter trials are required to elaborate a diagnostic algorithm, to define treatment policy, and to predict an outcome.

  8. MEDULLARY THYROID CARCINOMA

    Directory of Open Access Journals (Sweden)

    V. S. Medvedev

    2013-01-01

    Full Text Available Medullary thyroid carcinoma belongs to orphan diseases affecting a small part of the population. Multicenter trials are required to elaborate a diagnostic algorithm, to define treatment policy, and to predict an outcome.

  9. Renal cell carcinoma

    Science.gov (United States)

    Renal cell carcinoma is a type of kidney cancer that starts in the lining of very small tubes (tubules) in the kidney. ... cancer; Kidney cancer; Hypernephroma; Adenocarcinoma of renal cells; Cancer - kidney

  10. Estudio de la frecuencia, distribución y rendimiento diagnóstico en las lesiones neoplásicas sincrónicas del carcinoma colo-rectal Study of frequency, distribution and diagnostic performance in synchronic neoplastic lesions of colorectal carcinoma

    OpenAIRE

    A. Borda; J.M. Martínez-Peñuela; Prieto, C.; Muñoz, M; Carretero, C.; F. Borda

    2008-01-01

    Objetivo. Analizar la frecuencia, características y el diagnóstico de las lesiones neoplásicas sincrónicas en el cáncer colo-rectal. Material y métodos. Se han revisado 384 cánceres colo-rectales, diagnosticados mediante colonoscopia completa y resecados. Se ha determinado los cánceres sincrónicos y las características de los adenomas: número, tamaño, tipo histológico, displasia, así como su localización en el colon y respecto al carcinoma. Resultados. Se han encontrado 28 cánceres sincrónico...

  11. Radiotherapy of anal carcinomas

    International Nuclear Information System (INIS)

    Report is given on radiotherapy of anal carcinomas. Own experiences and a review of the recent literature are presented. Prior to surgery radiotherapy with high energy electrons in combination with chemotherapy is in the foreground. Especially in cloacogenous carcinoma no residual tumor was found after preliminary irradiation. Our recommended conception of post-operative radiotherapy of the regional lymphatic draining vessels is outlined. (orig./MG)

  12. Papillary thyroid carcinoma

    DEFF Research Database (Denmark)

    Godballe, C; Asschenfeldt, P; Sørensen, J A;

    1994-01-01

    The age influence on the prognosis of papillary thyroid carcinoma was analyzed in a group of 67 patients. A marked decline in cause-specific survival was found for patients older than 60 years of age at the time of diagnosis. In order to find a tumor-biological explanation of the prognostic...... invasion and distant metastases. The results indicate that 60 years of age the time of diagnosis may be the "prognostic break-point" for papillary thyroid carcinoma....

  13. [Pulmonary sarcomatoid carcinoma].

    Science.gov (United States)

    Antoine, Martine; Vieira, Thibault; Fallet, Vincent; Hamard, Cécile; Duruisseaux, Michael; Cadranel, Jacques; Wislez, Marie

    2016-01-01

    Pulmonary sarcomatoid carcinomas are a rare group of tumors accounting for about one percent of non-small cell lung carcinoma (NSCLC). In 2015, the World Health Organization classification united under this name all the carcinomas with sarcomatous-like component with spindle cell or giant cell appearance, or associated with a sarcomatous component sometimes heterologous. There are five subtypes: pleomorphic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma and pulmonary blastoma. Clinical characteristics are not specific from the other subtypes of NSCLC. Epithelial to mesenchymal transition pathway may play a key role. Patients, usually tobacco smokers, are frequently symptomatic. Tumors are voluminous more often peripherical than central, with strong fixation on FDG TEP CT. Distant metastases are frequent with atypical visceral locations. These tumors have poorer prognosis than the other NSCLC subtypes because of great aggressivity, and frequent chemoresistance. Here we present pathological description and a review of literature with molecular features in order to better describe these tumors and perhaps introduce new therapeutics. PMID:26778815

  14. Rescate de colgajo muscular de trapecio con isla cutánea en paciente lesionado medular que precisa rehabilitación inmediata Rescue of a pedicled trapezious muscle flap with skin paddle in a patient with spinal cord injury who needded inmediate rehabilitation

    Directory of Open Access Journals (Sweden)

    J.M. Arévalo Velasco

    2011-12-01

    Full Text Available La terapia por presión negativa (subatmosférica es una modalidad no invasiva de tratamiento que hoy en día está incluida en el arsenal terapéutico de cualquier Servicio no sólo de Cirugía Plástica, sino también de Cirugía General, Cirugía Vascular y Traumatología. Se puede aplicar en el tratamiento de heridas tanto crónicas como agudas más o menos complejas, con el fin de evitar aumentar el tiempo y el número de curas necesarias y además el realizar cirugías que conlleven una elevada morbilidad para el paciente. Presentamos el caso de un paciente con cuadro depresivo secundario a la mala evolución clínica sufrida tras el desarrollo de una lesión medular transversa D4 ASIA C (incompleta de causa iatrogénica postquirúrgica (vertebroplastia-fusión vertebral por aplastamiento vertebral D3-D4, en el que tras más de 6 meses de evolución tórpida de una úlcera dorsal alta, se realizó un colgajo de músculo trapecio pediculado con paleta cutánea para cobertura del defecto, en cuyo postoperatorio inmediato sufrió, de nuevo iatrogénicamente, una pérdida parcial de dicha paleta y un seroma importante en la zona dadora. Consideramos de interés este caso porque la aplicación de terapia de presión negativa empleando el sistema VAC® nos permitió: 1 Minimizar la pérdida de tejido del colgajo. 2 Disminuir el número de curas semanales hasta 1 ó 2. 3 Disminuir también el tiempo empleado en cada cura. 4 Que el paciente pudiera desplazarse en su silla de ruedas con dos sistemas VAC® portátiles hasta el gimnasio para no abandonar su programa de rehabilitación. 5 Que ante una evolución rápida e inesperada, el paciente experimentara una notable mejoría clínica de su estado depresivo-ansioso y 6 La colocación final de un sistema VAC-VIA® de última generación sobre los autoinjertos, para que el paciente pudiera continuar su tratamiento de terapia ocupacional y fisioterápico de extremidades superiores. Consideramos las

  15. del Nim

    Directory of Open Access Journals (Sweden)

    Arturo Martínez Rodríguez

    2007-01-01

    Full Text Available Dado su uso específico como fuente de insecticidas naturales de fácil biodegradación, entre otras ventajas, el cultivo del árbol Nim ha sido mundialmente extendido en muchas regiones de Asia, África, Australia y América Latina, incluyendo Cuba. La cosecha del fruto del Nim se hace engorrosa debido a la altura que adquieren estos árboles a los pocos años de sembrados, siendo la cosecha mecánica mediante sacudidores de ramas o del tronco, una posible vía de solución práctica de esta problemática. En el presente trabajo se efectúa, mediante la simulación con el empleo de herramientas CAD-3D y programas de análisis por elementos finitos, un análisis modal abarcador de un número importante de modos de vibración del sistema fruto-pedúnculo del Nim. Como resultado del estudio se pudieron recomendar entornos de frecuencias de las vibraciones a aplicar con mejores expectativas durante la cosecha mecanizada de este producto.

  16. Simultaneous Development of Renal Cell Carcinoma and Multifocal Urothelial Carcinoma

    OpenAIRE

    Cheng-Keng Chuang; Heng-Chang Chuang; Kwai-Fong Ng

    2008-01-01

    Simultaneous occurrence of multifocal urothelial carcinoma (UC) and ipsilateral renalcell carcinoma (RCC) is rare. We report a 67-year-old woman with multifocal, infiltratingurothelial carcinoma and unilateral renal cell carcinoma. She was referred to our departmentbecause of painless gross hematuria. Cystoscopy, computed tomography and retrogradepyelography studies revealed bladder, bilateral renal and ureter UC. She was treated withtransurethral resection of the bladder tumor followed by bi...

  17. Early onset sebaceous carcinoma

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    Kaltreider Sara A

    2011-09-01

    Full Text Available Abstract Background Ocular sebaceous carcinoma can masquerade as benign lesions resulting in delay of diagnosis. Early recognition is even more difficult in young patients where the disease rarely occurs. Here, we provide a clinicopathological correlation of ocular sebaceous carcinoma in a young individual lacking history of hereditary cancer or immunosuppression. Findings A detailed histopathological study including p53 DNA sequencing was performed on an aggressive sebaceous carcinoma presenting in a healthy 32 year-old Caucasian woman. She had no history of retinoblastoma, evidence for a hereditary cancer syndrome, or radiation therapy. However, she potentially was at risk for excessive UV light exposure. A detailed review of the literature is also provided. A moderately well differentiated sebaceous carcinoma was established histopathologically arising from the meibomian gland of the upper eyelid. In most areas, the cytoplasm contained small but distinct Oil-red-O positive vacuoles. Direct sequencing of p53 identified a G:C→A:T mutation at a dipyrimidine site. The mutation results in substitution of arginine for the highly conserved glycine at residue 199 located at the p53 dimer-dimer interface. Energy minimization structural modeling predicts that G199R will neutralize negative charges contributed by nearby inter- and intramonomeric glutamate residues. Discussion This study points to the importance of recognizing that sebaceous carcinoma can occur in young patients with no evidence for hereditary cancer risk or radiation therapy. The G199R substitution is anticipated to alter the stability of the p53 tetrameric complex. The role of UV light in the etiology of sebaceous carcinoma deserves further study. Our findings, taken together with those of others, suggest that different environmental factors could lead to the development of sebaceous carcinoma in different patients.

  18. Changes in morphology of long bone marrow tissue of rats submitted to cryotherapy with liquid nitrogen Alterações na morfologia do tecido medular de ossos longos de ratos submetido à crioterapia com nitrogênio líquido

    Directory of Open Access Journals (Sweden)

    Fábio Wildson Gurgel Costa

    2012-02-01

    Full Text Available PURPOSE: To study the main effects of local use of liquid nitrogen on bone marrow tissue in rats. METHODS: The femoral diaphyses of 42 Wistar rats were exposed to three local and sequential applications of liquid nitrogen for one or two minutes, intercalated with periods of five minutes of passive thawing. The animals were sacrificed after one, two, four and 12 weeks and the specimens obtained were analyzed histomorphologically. RESULTS: In the second experimental week of one-minute protocol, histological degree of inflammation obtained a mean score of one (mild, ranging from 0 (absent or scarce and two (moderate (Kruskal-Wallis test p=0.01. In the second experimental week of two-minute protocol, degree of inflammation to the medullar tissue obtained an average score of two (Kruskal-Wallis test p=0.01. CONCLUSION: The degree of inflammation of the bone marrow tissue was higher in protocol of three applications of two minutes compared to protocol of three applications of one minute.OBJETIVO: Investigar os principais efeitos do uso local de nitrogênio líquido sobre o tecido medular ósseo em ratos. MÉTODOS: As diáfises femorais de 42 ratos Wistar foram expostas a três aplicações sequenciais locais de nitrogênio líquido por um ou dois minutos, intercaladas por períodos de cinco minutos de degelo espontâneo. Os animais foram sacrificados após uma, duas, quatro e 12 semanas e os espécimes obtidos foram analisados histomorfologicamente. RESULTADOS: Na segunda semana experimental do protocolo de um minuto, o grau histológico de inflamação obteve um escore médio de um (leve variando entre 0 (ausente ou escarço a dois (moderado (Teste de Kruskal-Wallis p=0.01. Na segunda semana experimental do protocolo de dois minutos, o grau histológico de inflamação do tecido medular obteve um escore máximo de dois (moderado (Teste de Kruskal-Wallis p=0.01. CONCLUSÃO: O grau de inflamação do tecido medular ósseo foi maior no protocolo de tr

  19. Nuevos tratamientos para el carcinoma renal New treatments for renal carcinoma

    OpenAIRE

    J. L. Pérez-Gracia; López-Picazo, J M; Olier, C. (Clara); ALFARO, C.; García-Foncillas, J; I. Melero; A. Gúrpide

    2007-01-01

    El cáncer renal presenta varias características que lo diferencian de otros tumores. El aumento de supervivencia observado en pacientes con carcinoma renal metastásico tras la realización de nefrectomía, rompe un concepto clásico de la oncología según el cual la extirpación del tumor primario en tumores avanzados carece de sentido. Junto con el melanoma, es el único tumor en el que tratamientos inmunomoduladores, como interleukina-2 producen un beneficio clínico al paciente. El tratamiento de...

  20. Análisis microbiológico de úlceras de presión en pacientes del Centro Nacional de Rehabilitación (CENARE

    Directory of Open Access Journals (Sweden)

    Karla Villalobos-Camacho

    2001-06-01

    Full Text Available Justificación y objetivo: Las úlceras de presión son áreas localizadas de tejido necrótico que tienden a desarro-llarse cuando los tejidos blandos son comprimidos entre una prominencia ósea y una superficie externa. La principal complicación de estas lesiones es que pueden constituirse en focos primarios de infecciones bacterianas. El objetivo del presente estudio fue realizar un análisis microbiológico de las úlceras de presión en pacientes de las unidades de Lesionados Medulares, Neurotrauma y Fisiatría General del Centro Nacional de Rehabilitación para determinar cuáles bacterias aerobias predominan en dichas lesiones y determinar el perfil de susceptibilidad a los antibióticos de los aislamientos bacterianos. Métodos: En este estudio se incluyeron 50 muestras recolectadas de 35 úlceras de presión en un total de 22 pacientes con daños en la médula espinal atendidos durante el período de agosto de 1998 a marzo de 1999. Las muestras fueron cultivadas en medios convencionales para el aislamiento de bacterias aerobias. La identificación de los aislamientos se realizó mediante pruebas bioquímicas y el sistema Vitek®. El perfil de susceptibilidad a antibióticos se realizó mediante la técnica Kirby-Bauer con respaldo por el sistema Vitek®. Resultados: Los microorganismos más frecuentemente aislados fueron P. aeruginosa, Staphylococcus coagulasa-negativa, S. intermedius y A. baumannii, los cuales presentaron resistencia contra diversos antibióticos. No se encontró ningún aislamiento de Staphylococcus aureus meticilina-resistente en las lesiones estudiadas. A lo largo del estudio se observó variabilidad en los perfiles de resistencia en aislamientos de P. aeruginosa de un paciente durante su internamiento, lo cual sugiere adquisición de genes de resistencia y sustitución de cepas. Los perfiles de resistencia sugieren una posible transmisión intrahospitalaria de cepas de P. aeruginosa, Staphylococcus coagulasa

  1. Potencial del agua del suelo

    OpenAIRE

    Bustamante Heliodoro

    2012-01-01

    La energía potencial del agua presenta diferencias de un punto del suelo a otro; esas diferencias son las que originan el movimiento del agua de acuerdo a la tendencia universal de la materia en el sentido de moverse de donde la energía potencial es mayor a donde dicha energía es menor. En el suelo el agua en consecuencia se mueve hacia donde su energía decrece hasta lograr su estado de equilibrio. Se desprende entonces que la cantidad de energía potencial absoluta contenida en el agua, no es...

  2. PREGNANCY WITH CARCINOMA CERVIX

    Directory of Open Access Journals (Sweden)

    Sunita

    2014-05-01

    Full Text Available : Invasive cervical cancer during pregnancy is rare, but is a dilemma for women and their physicians. Pregnancy provides a good opportunity to the obstetrician to screen the patient for cervical neoplasia. We report a case of pregnancy with carcinoma cervix. A 40 years old lady G5P3+1 presented in casualty at 38 weeks 2 days with bleeding per vaginum. On examination she was stage III b Carcinoma Cervix with term pregnancy. She underwent classical cesarean section followed by EBRT and brachytherapy. The main objective of this case report is to highlight the need of doing cervical screening routinely in pregnancy in a low resource setting also to decrease the burden of carcinoma cervix in society

  3. Simultaneous Laryngeal Squamous Cell Carcinoma and Papillary Thyroid Carcinoma

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    Bighan Khademi

    2011-04-01

    Full Text Available The association of squamous cell carcinoma of the larynx with thyroid papillary carcinoma is an unusual finding. From 2004 to 2011, approximately 250 patients underwent laryngectomies due to squamous cell carcinoma of the larynx at the Otolaryngology Department of Khalili Hospital, affiliated with Shiraz University of Medical Sciences, Shiraz, Iran. In three patients, synchronous occurrence of squamous cell carcinoma and thyroid papillary carcinoma was found. Histopathologic study of the lymph nodes revealed metastatic papillary thyroid carcinoma in one case. We report three cases of thyroid papillary carcinoma incidentally found on histological examinations of resected thyroid lobes, as a procedure required for treatment of head and neck squamous cell carcinoma. In comparison, laryngeal squamous cell carcinoma needs more aggressive treatment than well-differentiated thyroid carcinoma. The prevalence of thyroid papillary carcinoma, as an incidental finding in our study was 0.01%. Therefore, preoperative evaluation of the thyroid gland by ultrasonography and fine needle aspiration biopsy of suspicious lesions is recommended in patients who are candidates for open laryngectomy.

  4. Primary fallopian tube carcinoma

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    Mladenović-Segedi Ljiljana

    2009-01-01

    Full Text Available Introduction. Primary fallopian tube carcinoma is extremely rare, making 0.3-1.6% of all female genital tract malignancies. Although the etymology of this tumor is unknown, it is suggested to be associated with chronic tubal inflammation, infertility, tuberculous salpingitis and tubal endometriosis. High parity is considered to be protective. Cytogenetic studies show the disease to be associated with over expression of p53, HER2/neu and c-myb. There is also some evidence that BRCA1 and BRCA2 mutations have a role in umorogeneis. Clinical features. The most prevailing symptoms with fallopian tube carcinoma are abdominal pain, abnormal vaginal discharge/bleeding and the most common finding is an adnexal mass. In many patients, fallopian tube carcinoma is asymptomatic. Diagnosis. Due to its rarity, preoperative diagnosis of primary fallopian tube carcinoma is rarely made. It is usually misdiagnosed as ovarian carcinoma, tuboovarian abscess or ectopic pregnancy. Sonographic features of the tumor are non-specific and include the presence of a fluid-filled adnexal structure with a significant solid component, a sausage-shaped mass, a cystic mass with papillary projections within, a cystic mass with cog wheel appearance and an ovoid-shaped structure containing an incomplete separation and a highly vascular solid nodule. More than 80% of patients have elevated pretreatment serum CA-125 levels, which is useful in follow-up after the definite treatment. Treatment. The treatment approach is similar to that of ovarian carcinoma, and includes total abdominal hysterectomy and bilateral salpingo-oophorectomy. Staging is followed with chemotherapy.

  5. Como Lo Hago Yo: Lipomas Medulares

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    Santiago Portillo

    2014-01-01

    Full Text Available Based on 82 cases reviewed, in 5% we observed pelvic associated anomalies. In children less than 3 years of age the consult was triggered by the lumbar-sacral mass. In older than 3 years (42% neurological problems triggered the consult. Only 24% at that age were concerned by the mass. The objective of the surgery is to untether the cord, and not to remove the entirety of the lipoma. Filum lipoma is the simplest to treat. Event though the French School is popular in Argentina I favor preventive surgery for lipoma even in asymptomatic patients. We had only 2.5% of added motor impairment and 6% in long term urological deficit.

  6. Carcinoma papilar tiroideo variante esclerosante difuso Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma

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    JL D'Addino

    2012-06-01

    Full Text Available Objetivo: Presentar un carcinoma inusual de tiroides y de difícil diagnóstico, su manejo y evolución. Caso clínico: Paciente de raza blanca de 37 años, desde hace 6 meses presentaba formación laterocervical derecha asintomática y ecografía con nódulo tiroideo sobre tiroides heterogénea. Sin antecedentes personales ni familiares de importancia. La punción de una adenopatía regional resultó adenocarcinoma y la del nódulo tiroideo: quiste coloide. Se intervino quirúrgicamente efectuándose un vaciamiento radical derecho y la biopsia por congelación informó carcinoma tiroideo por lo que se completó con vaciamiento cervical izquierdo y tiroidectomía total. La biopsia diferida fue: "carcinoma papilar difuso esclerosante con metástasis ganglionares en 5 de 6 ganglios peritiroideos derechos y en 7 de 9 ganglios cervicales, correspondiendo a 4 derechos y 3 izquierdos. Estadio: I, T3-N1b-M0. Se trató posteriormente con 3 dosis de yodo 131 y radioterapia externa por compromiso ganglionar mediastinal. A 6 meses de seguimiento hasta el presente, continúa libre de enfermedad. Los individuos con insulinorresistencia y síndrome metabólico presentan aumento del tamaño de la glándula tiroides y mayor prevalencia de nódulos. Tanto la insulina como la TSH se constituyen en factores de crecimiento para las células tiroideas, y los niveles de TSH son mayores en individuos con síndrome metabólico, presente en este caso. Conclusión: El carcinoma papilar, variante difusa esclerosante es un tumor inusual, de evolución más agresiva y con rápido compromiso extratiroideo y metástasis a distancia. Los autores declaran no poseer conflictos de interés.Objective: To report a case of a diffuse sclerosing papillary carcinoma, a rare type of thyroid carcinoma, of difficult diagnosis, its management and further follow-up. Case: 37-year-old white male who presented with a 6-month history of sudden onset of an asymptomatic right-sided lateral

  7. Maxillary sinus carcinoma

    International Nuclear Information System (INIS)

    Primary site control, anatomical site of failure, survival, and complications of treatment were determined in a retrospective review of primary maxillary sinus carcinoma. Sixty-one patients were treated by radiation followed by surgery and 35 by radiation alone. Primary tumor control was achieved in 69% of patients receiving combined treatment, 14% of patients treated with radiation alone, and 49% of all patients. Local control did not differ with histological type. Virtually all epidermoid and undifferentiated carcinoma recurrences occurred within 2 years, but 27% of adenocarcinomas recurred after 2 years

  8. Primary adrenal sarcomatoid carcinoma

    Directory of Open Access Journals (Sweden)

    Aftab S. Shaikh

    2014-03-01

    Full Text Available Adrenal sarcomatoid carcinomas are extremely rare tumors presenting with extensive locoregional spread at the time of diagnosis. Patients succumb to metastases within a couple of months. As a result, very few cases are reported in the literature until now. We present a case of a 62-year old female with non-functional sarcomatoid carcinoma of the right adrenal gland. There was no radiological evidence of locoregional metastases. Patient underwent right adrenalectomy. Follow up after 3 months showed para-aortic lymphadenopathy and similar left adrenal mass on computed tomography. Patient refused further treatment and succumbed to the disease. A brief case report with review of literature is presented.

  9. Nonfunctioning adrenocortical carcinoma.

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    Lele S

    1992-07-01

    Full Text Available The rarity of adrenocortical carcinoma prompted us to report a case who came with a history of swelling in the left flank associated with pain, weakness and loss of appetite. Ultrasonography revealed a left retroperitoneal mass which was removed by radical surgery along with the left kidney and spleen. On histopathological examination, a diagnosis of adrenocortical carcinoma was made. (Hough criteria score 2.97. The cells of the tumor were arranged in closely packed columns and cords supported by fibrovascular stroma. There was no evidence of metastasis.

  10. Carcinoma verrucoso periimplantario: A propósito de un caso Verrucous carcinoma arund implants: Case report

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    P. García Cañas

    2013-03-01

    Full Text Available Introducción: Las rehabilitaciones orales sobre implantes de titanio endoóseos se han convertido en estas últimas décadas en uno de los tratamientos más frecuentes realizados hoy día en odontología con un elevadísima tasa de éxito. Aunque son muy pocos los casos, están descritos cuadros de carcinomas surgidos en tejidos blandos periimplantarios, la mayor parte de ellos como recidivas de un cáncer oral previo tratado quirúrgicamente y rehabilitado funcionalmente con implantes. Objetivos: Se presenta el caso de un carcinoma verrucoso o tumor se Ackerman, variedad muy infrecuente de carcinoma de células escamosas (1 al 10%, que apareció alrededor de un implante dental sin antecedentes de carcinoma oral previo, lo cual está descrito de forma excepcional en la literatura. Discusión: El carcinoma verrucoso es una variante del carcinoma de células escamosas de bajo grado de malignidad. Es más frecuente en hombres por encima de los 50 años, y muy relacionado con el tabaco y el virus del papiloma humano. Su tratamiento es quirúrgico, obteniéndose pocas recidivas. Conclusiones: La simple posibilidad de aparición de esta grave patología, resalta la importancia de la eliminación de factores de riesgo y la realización de biopsias en cualquier lesión oral sospechosa como claves para evitar las graves consecuencias del cáncer oral.Introduction: Oral rehabilitations with endosseous titanium implants have become in recent decades one of the most common treatments performed today in dentistry with a high rate of success. Although few cases are described, there are some carcinomas arising in peri-implant soft tissues, most of them as a recurrence of a prior oral cancer treated surgically and then functionally rehabilitated with implants. Objectives: We report the case of a verrucous carcinoma, also know as Ackerman tumor, a very rare variety of squamous cell carcinoma (1 to 10%, which appeared around a dental implant with no history of

  11. Aspectos fisiopatológicos e assistenciais de enfermagem na reabilitação da pessoa com lesão medular Aspectos fisiopatológicos y asistenciales de enfermería en la rehabilitación de la persona con lesión medular Physiopathological aspects and nursing care on rehabilitation of patient with spinal cord injury

    Directory of Open Access Journals (Sweden)

    Denise Stela Bruni

    2004-03-01

    Full Text Available O traumatismo raquimedular é uma agressão à medula espinhal que pode ocasionar danos neurológicos, tais como alteração das funções motora, sensitiva e autônoma. Este artigo tem como propósito relatar detalhadamente as principais complicações clínicas resultantes desse tipo de lesão, e apresentar as intervenções assistenciais de enfermagem que possam auxiliar na promoção do bem estar e na melhoria da qualidade de vida dos pacientes, seja em caráter de acometimento já instalado ou profilático.El traumatismo de la médula espinal puede llevar a daños neurológicos, incluso a la alteración de las funciones motora, sensorial y autonómica. En este trabajo nos proponemos descubrir detalladamente las más importantes complicaciones clínicas resultantes de ese tipo de lesión, y enseñar las intervenciones asistenciales de enfermería que puedan ayudar en la promoción del bienestar y en la mejora de la calidad de vida de los pacientes, sea en carácter de lesión ya instalada o en carácter profiláctico.Spinal cord injury can cause neurological damage such as alterations in the motor, sensitive and autonomic function. In this paper, details of clinical complications such as PVT, infection, respiratory insufficiency, pressure ulcers, autossomic disreflection, orthostatic hypotension, sphincteral-vesical and intestinal disfunctions, are related. And will also present prophylactic and therapeutic nursing care interventions designed for the well-being and improvement in life quality for patients.

  12. Miasis en paciente con Carcinoma Basocelular

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    Dr. Hugo Pérez Vedia

    2012-12-01

    Full Text Available Paciente de sexo masculino, de 71 años de edad, proveniente de la provincia Chapare, Cochabamba, es remitido por sus familiares al servicio de Infectologíadel Hospital Obrero Nº2 Caja Nacional de Salud, tras presentar cuadro clínico de varios días de evolución, caracterizado por lesión ulcerada de bordes irregulares, con secreciónserosanguinolenta localizada en hemicara derecha, con extensión a tejidos profundos y destrucción ósea con pérdida del pabellón auricular derecho,destrucción de la fosa nasal derecha, exposición de globo ocular por destrucción de tejido,destrucción del paladar duro y blando del lado derecho, lengua saburral, faringe hiperémica,acompañado de dolor intenso y signos de un procesoinfeccioso-inflamatorio en la zona, además de presentar larvas en dicha lesión, y antecedentes de carcinoma basocelular de 20 añosde evolución.

  13. Basal Cell Carcinoma

    Science.gov (United States)

    ... resources Meet our partners Español Donate Diseases and treatments Acne and rosacea Bumps and growths Color problems Contagious skin diseases ... cell carcinoma public SPOT Skin Cancer™ Diseases and treatments Acne and rosacea Bumps and growths Color problems Contagious skin diseases ...

  14. Squamous Cell Carcinoma

    Science.gov (United States)

    ... resources Meet our partners Español Donate Diseases and treatments Acne and rosacea Bumps and growths Color problems Contagious skin diseases ... cell carcinoma public SPOT Skin Cancer™ Diseases and treatments Acne and rosacea Bumps and growths Color problems Contagious skin diseases ...

  15. Bronchogenic Carcinoma in Khartoum

    International Nuclear Information System (INIS)

    The prospective study was conducted in the period between April 1996 and April 1997, and included 26 with bronchogenic carcinoma. The diagnosis was proved histologically in 24 patients, and it was based on the clinico-radiological picture in the remainder two patients. The mean age was 49 years,SD ±16.5. The male:female ratio was 2.2:1.0. All five patients under thirty years were females. 13 patients(50%) were smokers. The mean duration of smoking was 28 years, SD±8. The mean number of cigarettes per day was 24, SD±11.8. Chest symptoms and signs were observed in 92% and 48% of patients respectively, and 10 patients(38%) showed evidence of metastases at diagnosis. Bronchioscopic was done in 11 patients and transthorasic needle biopsy in 6. The diagnosis in the remainder of patients was confirmed by operative biopsy, or pleural cytology, or pleural biopsy or by biopsy from secondaries. The histology revealed squamous cell carcinoma in 14 patients, small cell carcinoma in 5, adenocarcinoma in 3, large cell carcinoma in 2, and the histology was not obtained in two patients. Radiotherapy alone was given to 9 patients. Ten patients underwent surgery followed by radiotherapy in 5 patients and chemotherapy in 4. Only 10 patients survived for more than 3 months. One patient survived for more than one year after diagnosis.(Author)

  16. Culturas del Mundo

    DEFF Research Database (Denmark)

    Benwell, Ann Fenger; Costa, Alberto; Waehle, Espen

    2006-01-01

    ’Culturas del mundo. Colecciones del Museo Nacional de Dinamarca’ with Ann Fenger Benwell in Culturas del Mundo. Colecciones del Museo Nacional de Dinamarca, ed. Silvia Sauquet, Fundación "la Caixa", Barcelona 2006, pp. 31-39......’Culturas del mundo. Colecciones del Museo Nacional de Dinamarca’ with Ann Fenger Benwell in Culturas del Mundo. Colecciones del Museo Nacional de Dinamarca, ed. Silvia Sauquet, Fundación "la Caixa", Barcelona 2006, pp. 31-39...

  17. Nuevos tratamientos para el carcinoma renal New treatments for renal carcinoma

    Directory of Open Access Journals (Sweden)

    J. L. Pérez-Gracia

    2007-12-01

    Full Text Available El cáncer renal presenta varias características que lo diferencian de otros tumores. El aumento de supervivencia observado en pacientes con carcinoma renal metastásico tras la realización de nefrectomía, rompe un concepto clásico de la oncología según el cual la extirpación del tumor primario en tumores avanzados carece de sentido. Junto con el melanoma, es el único tumor en el que tratamientos inmunomoduladores, como interleukina-2 producen un beneficio clínico al paciente. El tratamiento del cáncer renal metastásico con interleukina-2 intravenosa a dosis altas ha confirmado en estudios aleatorios que puede producir respuestas completas de muy larga duración, en la práctica equivalentes a la curación. Por último, el cáncer renal está siendo empleado como modelo clínico para demostrar la eficacia de múltiples tratamientos dirigidos frente a nuevas dianas. En la actualidad se están estudiando más de 30 nuevos fármacos como tratamiento del cáncer renal, habiendo sido el primer tumor en el que se ha demostrado el beneficio clínico del tratamiento con inhibidores de la angiogénesis. En este artículo se revisan los aspectos más relevantes sobre el cáncer renal, incluyendo epidemiología, factores pronósticos, presentación clínica; bases moleculares y el estado actual de desarrollo de varios de los múltiples fármacos que se están estudiando en esta enfermedad.Renal cell carcinoma presents several unique features, which distinguish it from other tumours. The increase in survival that has been described in patients with renal cell carcinoma following nephrectomy breaks a classical rule of oncology, which states that surgery of the primary tumour has no role in the treatment of patients with advanced disease. Together with melanoma, it is the only tumour in which immunomodulatory treatments with drugs such as interleukin-2 produces a clinical benefit to patients. In randomized trials treatment of metastatic renal cell

  18. Valoración de la expresión de Bcl2 y ki-67 en el carcinoma epidermoide de pulmón. Alteraciones génicas asociadas. Correlación con variables anatomoclínicas

    OpenAIRE

    Montejo Maillo, Beatriz

    2010-01-01

    [ES]Aparte del estudio clinico del tumor, escasos factores parecen influir en el pornóstico del carcinoma epidermoide de pulmón y en los úlitmos 20 años, apenas se ha modificado la supervivencia [EN]Apart from the clinical study of tumor, few factors appear to influence the porn squamous cell carcinoma of lung and in 20 years last article, has remained largely unchanged survival

  19. Ipsilateral synchronous renal cell carcinoma and transitional cell carcinoma.

    OpenAIRE

    Lee, J. W.; Kim, M. J.; Song, J H; Kim, J H; Kim, J. M.

    1994-01-01

    The simultaneous occurrence of renal cell carcinoma(RCC) and transitional cell carcinoma(TCC) in the same kidney is unusual. We report a 53-year-old man with ipsilateral synchronous renal adenocarcinoma and renal pelvic transitional cell carcinoma with severe hypercalcemia and a huge staghorn calculus in the opposite kidney. The patient was admitted to the hospital because of left flank pain and intermittent fever which he had had for 2 months. Computerized tomography revealed a huge stone in...

  20. Carcinoma mucoepidermóide Mucoepidermoid carcinoma

    Directory of Open Access Journals (Sweden)

    CRISTIANO FEIJÓ ANDRADE

    2002-11-01

    Full Text Available O carcinoma mucoepidermóide é uma neoplasia infreqüente da árvore traqueobrônquica e de etiologia ainda indeterminada. Sua localização endobrônquica preferencial freqüentemente causa sintomas respiratórios obstrutivos e pneumopatias de resolução lenta. Normalmente, são tumores de crescimento lento, mas que podem apresentar comportamento agressivo, com invasão local e metástases para linfonodos, dependendo das suas características histopatológicas. O tratamento de eleição é o cirúrgico, com ressecção completa, seja através de lobectomia ou broncotomia e broncoplastia. O prognóstico dependerá do grau de diferenciação celular desses tumores. Relata-se um caso dessa rara neoplasia descrevendo suas características clínicas, radiológicas e o tratamento cirúrgico.Mucoepidermoid carcinoma is an uncommon neoplasm of the tracheobronchial tree, of unknown etiology. Its preferred endobronchial location often results in respiratory symptoms such as obstruction of the airways and lung diseases of slow recovery. They usually are slow growing tumors although they may present an aggressive behavior with local invasion and lymph node metastases depending on their histopathologic characteristics. The mainstay therapy is complete surgical resection either by means of lobectomy or by lung sparing procedures such as bronchotomy and bronchoplasty. Prognosis depends upon the degree of cellular differentiation of the tumors. The authors report a case of this rare neoplasia and describe the clinical and radiographic characteristics, and the surgical treatment.

  1. Team practice for laryngeal carcinoma. Glottic carcinoma

    International Nuclear Information System (INIS)

    To compare the results of treatment performed with and without team practice in glottic laryngeal cancer patients, including local control rate and preservation of voice. Since April 1991, radiation oncologists, radiologists and otolaryngologists have worked in close collaboration to treat head and neck cancer patients in the Kurume University Hospital. Treatment results of a total of 419 patients with glottic cancer were compared with or without team practice. In group A (period, Jan 1978 to Mar 1991), 237 glottic laryngeal cancer patients were treated before team practice. In group B (period, Apr 1991 to Mar 1997), 182 patients were treated with team practice. All patients had histologically proven invasive squamous cell carcinoma. Follow-up period was at least 2 years. In group A, a laser was preferentially used for T1 lesions (T1a: 41 lesions, 52.6%, T1b: 7 lesions, 15.6%), and partial laryngectomy or total laryngectomy was preferentially used for T2 lesions (partial laryngectomy: 21 lesions, 30.9% and total laryngectomy: 10 lesions, 14.7%). On the other hand, in group B, 126 (81.8%) T1 and T2 lesions were treated with radical radiation with or without laser. Local control rate of T1 and T2 cancer improved significantly from 78.3% for group A patients to 91.2% for group B patients (p<0.01). Larynx preservation rate improved slightly from 88.6% to 95.0%. Five year cause-specific survival rate for all stage I to IV patients improved from 94.8% to 96.5%, but was not significant. Relapse-free survival rate improved significantly from group A to group B: from 75.1% to 87.4% (p<0.01). Team practice has effective results in improved local control and preservation of natural voice for patients with glottic carcinoma. (author)

  2. Carcinoma triquilemal: relato de caso Trichilemmal carcinoma: case report

    OpenAIRE

    Miguel Roismann; Rosyane Rena de Freitas; Leandro Carvalho Ribeiro; Marcos Flávio Montenegro; Luciano José Biasi; Juliana Elizabeth Jung

    2011-01-01

    O carcinoma triquilemal é um tumor raro, que ocorre, geralmente, na pele exposta ao sol, principalmente face, couro cabeludo, pescoço e dorso das mãos, em indivíduos idosos, entre a 4ª e 9ª décadas de vida, sem predilação por sexo. O presente estudo mostra um caso de carcinoma triquilemal, recidivado, de difícil tratamento, em mesma topografia de um carcinoma basocelular tratado previamente com cirurgia e radioterapia.The trichilemmal carcinoma is a rare tumor that usually occurs on sun-expos...

  3. Profundidad tumoral y variables histopatológicas en el carcinoma epidermoide lingual: Estudio retrospectivo sobre 60 pacientes Tumoral thickness and histopathological parameters in the squamous cell carcinoma of tongue: A retrospective evaluation over 60 patients

    OpenAIRE

    JD Sánchez López; MA Sicilia Gutiérrez; LM Capitán Cañadas; I. Labrot Moleón; S. Martínez-Villalobos Castillo; E. Valencia Laseca

    2005-01-01

    I.- Introducción: La profundidad tumoral representa uno de los principales factores pronósticos del carcinoma epidermoide lingual. II.-Objetivos: Verificar si el espesor máximo tumoral se correlaciona con parámetros histopatológicos agresivos. III.-Material y Métodos: -Diseño: Estudio retrospectivo de base hospitalaria (Enero-1990 a Julio-1997) constituido por 60 pacientes afectos de carcinoma escamoso lingual. -Variables: Filiación del paciente, parámetros histopatológicos y profundidad tumo...

  4. El origen y diversificación del crecimiento cambial atípico en plantas fósiles: procesos del desarrollo involucrado

    Directory of Open Access Journals (Sweden)

    Josefina Bodnar

    2012-06-01

    Full Text Available En el registro fósil encontramos una serie de morfologías, cuyo origen sólo puede ser inferido a partir de los estudios ontogenéticos. De este modo, la comprensión de los procesos del desarrollo en plantas y el patrón resultante es de suma importancia en Paleobotánica. En este trabajo, se presenta la relación que existe entre los procesos del desarrollo y los diversos patrones observados en el crecimiento secundario de las plantas fósiles. Se estudiaron superficies pulidas, peels y cortes petrográficos de troncos silicificados correspondientes a Lycopsida, Sphenopsida, Medullosales, Corystospermales y Cycadales. Se identificaron una variedad de patrones cambiales, que pueden ser reunidos en dos grupos principales: patrón en espiral y variantes cambiales (e.g. unifacialidad, fragmentación radial y tangencial de elementos vasculares, polixilia, orientación inversa y sistema vascular medular. La aparición del patrón en espiral estuvo relacionada con el origen del clado de las Lygnophyta. Las variantes cambiales caracterizan grupos particulares, y han experimentado una diversificación evolutiva muy importante, vinculada con eventos del desarrollo.Origin and diversification of atypical cambial growth in fossil plants: developmental processes involved. We found a series of morphologies in the fossil record whose origin can only be inferred by means of ontogenetic studies. Therefore, comprehension of plant developmental processes and their resultant patterns are extremely important in Paleobotany. In this contribution, we exposed the relation between developmental processes and the different patterns observed in fossil plant secondary growth. Polished surfaces, peels and thin slides of silicified trunks belonging to Lycopsida, Sphenopsida, Medullosales, Corystospermales and Cycadales, were studied. We identified a diversity of cambial patterns which can be clustered in two main groups: whirling pattern and cambial variants (e

  5. Tumor suppressor and hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Juliette Martin; Jean-Frangois Dufour

    2008-01-01

    A few signaling pathways are driving the growth of hepatocellular carcinoma. Each of these pathways possesses negative regulators. These enzymes, which normally suppress unchecked cell proliferation, are circumvented in the oncogenic process, either the over-activity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective. The loss of several key tumor suppressors has been described in hepatocellular carcinoma. Here, we systematically review the evidence implicating tumor suppressors in the development of hepatocellular carcinoma.

  6. Papillary renal cell carcinoma

    International Nuclear Information System (INIS)

    Between 1976 and 1987, 395 patients with kidney tumors were studied with radiological techniques and sonography. In 37 cases (9.4%) histopathology diagnosed pure papillary renal cell carcinoma. Analyzing the radiographic patterns of these neoplasms, the authors observed constantly diminished vascularity (100%) frequent calcifications (35.1%) and necrotic areas (51.3%). Such X-ray features are not specific: nevertheless, their coexistence is strongly suggestive of papillary renal cell cancer. No consistent US pattern was found; however, necrotic areas were easily demonstrated in most cases. It must be stressed how patients with papillary carcinoma experienced a longer post-operative survival; it has not yet been established whether such favorable behavior is due to low biological aggressiveness or to earlier diagnosis

  7. Biomarkers for hepatocellular carcinoma.

    Science.gov (United States)

    Behne, Tara; Copur, M Sitki

    2012-01-01

    The hepatocellular carcinoma (HCC) is one of the most common malignant tumors and carries a poor survival rate. The management of patients at risk for developing HCC remains challenging. Increased understanding of cancer biology and technological advances have enabled identification of a multitude of pathological, genetic, and molecular events that drive hepatocarcinogenesis leading to discovery of numerous potential biomarkers in this disease. They are currently being aggressively evaluated to establish their value in early diagnosis, optimization of therapy, reducing the emergence of new tumors, and preventing the recurrence after surgical resection or liver transplantation. These markers not only help in prediction of prognosis or recurrence but may also assist in deciding appropriate modality of therapy and may represent novel potential targets for therapeutic interventions. In this paper, a summary of most relevant available data from published papers reporting various tissue and serum biomarkers involved in hepatocellular carcinoma was presented. PMID:22655201

  8. Soft tissue myoepithelial carcinoma

    OpenAIRE

    Stojšić Zorica; Brašanac Dimitrije; Bacetić Dragoljub; Janković Radmila; Drndarević Neda

    2006-01-01

    Background. Myoepitheliomas are tumors composed predominantly or exclusively of myoepithelial cells, usually arising in salivary glands. Cutaneous/soft tissue localization is very rare, especially for the malignant myoepitheliomas. Case report. We presented a case of myoepithelial carcinoma involving subcutaneous adipose tissue of the left forearm in a woman aged 62 years. The tumor was composed of epithelioid and hyaline cell types, arranged in diffuse sheets, nests and loose clusters within...

  9. Immunology of hepatocellular carcinoma

    OpenAIRE

    Sachdeva, Meenakshi; Chawla, Yogesh K.; Arora, Sunil K

    2015-01-01

    Hepatocellular carcinoma (HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. Globally, HCC is the sixth most prevalent cancer and the third-most prevalent reason for neoplastic disease-related deaths. A diverse array of infiltrating immunocytes regulates the development and progression of HCC, as is the case in many other cancers. An understanding of the various immune components during HCC becomes necessary so that novel therapeutic strategies can ...

  10. Uterine papillary serous carcinoma.

    Science.gov (United States)

    Moore, Kathleen N; Fader, Amanda Nickles

    2011-06-01

    Uterine papillary serous carcinoma (UPSC) is a histologic variant of endometrial cancer that accounts for only 10% of new cases of uterine cancer but is responsible for 40% of deaths from the disease. UPSC is an aggressive tumor with a predilection for early spread beyond the uterus. Treatment for UPSC typically entails surgery and in most women is followed by multimodality adjuvant therapy. In this review, we describe the epidemiology, natural history, treatment, and outcome of UPSC. PMID:21508697

  11. Penis squamous cell carcinoma

    OpenAIRE

    Leonor Hernández Piñero; José Luis Rodríguez López; María de Lourdes Menéndez Villa

    2015-01-01

    Cancer has become a first order health problem worldwide, despite the great diagnostic and therapeutic programs achieved during the last years. This is a clinical case of an 81- year-old patient with personal and social history of promiscuous and unprotected sexual behavior that shows a vegetative lesion in his gland and numerous inguinal adenopathies. Biopsy confirms the diagnosis of squamous cell carcinoma infiltrating the penis, which is a relatively rare pathology which is generally diagn...

  12. Carcinoma-associated antigens

    International Nuclear Information System (INIS)

    This invention relates to novel antigens associated with breast carcinoma, anti-sera specific to said antigens, 125I-labeled forms of said antigens and methods of detecting said antigens in serum or plasma. The invention also relates to a diagnostic kit containing standardised antigens or antisera or marked forms thereof for the detection of said antigens in human blood, serum or plasma. (author)

  13. Primary urethral carcinoma

    International Nuclear Information System (INIS)

    The casuistry of the Urologic Service of A.C. Camargo Hospital - Antonio Prudente Foundation - Sao Paulo (Brazil) is presented. Fourteen patients with primary urethral carcinoma are studied from 1954 to 1980. The treatment used is reported: surgery,radiotherapy and/or chemotherapy. The modalities of radiation therapy included brachitherapy alone and combination with external radiation with total doses of 60 to 80 Gy. (M.A.C)

  14. Thermoradiotherapy for colorectal carcinoma

    International Nuclear Information System (INIS)

    The Japanese Society for Therapeutic Radiology and Oncology conducted a survey of the present state of thermoradiotherapy for colorectal carcinomas in Japan. In this survey, 105 cases at the 9 institutions were registered which had been treated from January 1981 to December 1992. From this data, we analyzed the trend of hyperthermia for the colorectal carcinoma and the treatment parameters which might have an influence on the treatment results. Ninety-four of 105 cases were recurrent or metastatic lesions. Mainly, the RF capacitive heating equipment was applied for the colorectal carcinoma. The number of cases in which hyperthermia were given once or twice a week were almost equal, and there was no significant difference in the treatment response rate. The mean duration of hyperthermia at therapeutic temperature was 42 min. Measurements of temperature in lesions were performed in 86% of sessions, and the mean tumor temperature was 43.1degC. Higher maximum tumor temperature and longer treatment time have brought significantly better response. Responder groups have shown better survival than non-responder groups. Acute reactions associated with hyperthermia were as follows: pain in 35 cases, burn and/or skin erosion in 12 cases, abscess formation in 3 cases and others in 3 cases. Late effects of treatment were ileus in 9 cases, ulcer of intestinal tract in 5 cases, subcutaneous fibrosis in 3 and others in 6. In conclusion, the application of thermoradiotherapy for reflactory colorectal carcinoma may contribute to the improvement of prognosis and quality of life of patients. (author)

  15. Carcinoma in a fibroadenoma.

    Directory of Open Access Journals (Sweden)

    Sarela A

    1995-01-01

    Full Text Available A carcinoma arising within a fibroadenoma is an unusual occurrence, with only a little over 100 reported cases. The purpose of this report is to increase the awareness of this entity and to discourage the practice of rendering a diagnosis on gross examination of the tumor. We are reporting a case with two distinct primary tumors within the same breast, one of which was arising within the fibroadenoma. Only two such cases have been previously reported.

  16. Differentiated nasosinusal epidermoid carcinoma

    International Nuclear Information System (INIS)

    Two case reports of young patients, who were treated in the Otolaryngology Department from 'Dr. Joaquin Castillo Duany' Teaching Clinical Surgical Hospital in Santiago de Cuba are presented. One of the cases presented nasal obstruction, rhinorrhoea and facial pain, for 7 months; the other one presented an increase of volume in the right ocular globe. In both, the results of the biopsy confirmed the diagnosis of differentiated nasosinusal epidermoid carcinoma

  17. Prevention of hepatocellular carcinoma.

    Science.gov (United States)

    Kew, Michael C

    2010-01-01

    Because of its frequency and grave prognosis, preventing hepatocellular carcinoma is an urgent priority. Prevention should be possible because environmental carcinogens-chronic hepatitis B and C virus infections, dietary exposure to aflatoxins, and iron overload-cause the great majority of these tumors. Chronic hepatitis B virus infection accounts for 55% of global hepatocellular carcinomas and 80% of those in the high-incidence Asia Pacific and sub-Saharan African regions. In these regions the infection that becomes chronic is predominantly acquired very early in life. A safe and effective vaccine against this virus is available and its universal inclusion in the immunization of infants has already resulted in a marked reduction of chronic infection and a 70% decrease in the occurrence of hepatocellular carcinoma in those immunized. Chronic hepatitis C virus infection is the major cause of hepatocellular carcinoma in industrialized countries. The infection is mainly acquired in adulthood and, until a vaccine becomes available, prevention will consist mainly of identifying, counselling, and treating chronically infected individuals, preventing spread of the virus by the use of safe injection practices (particularly in intravenous drug abusers), and screening all donated blood for the presence of the virus. 4.5 billion of the world.s population are exposed to dietary aflatoxins. Prevention involves treating susceptible crops to prevent fungal contamination, and handling the foodstuffs in such a way as to prevent contamination during storage. Iron overload in hereditary hemochromatosis can be prevented by repeated venesection and in African dietary iron overload by fermenting the home-brewed beer in iron-free containers. PMID:20526004

  18. Pathobiology of ovarian carcinomas

    OpenAIRE

    Mojgan Devouassoux-Shisheboran; Catherine Genestie

    2015-01-01

    Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular bas...

  19. Emerging therapies for thyroid carcinoma.

    LENUS (Irish Health Repository)

    Walsh, S

    2012-02-01

    Thyroid carcinoma is the most commonly diagnosed endocrine malignancy. Its incidence is currently rising worldwide. The discovery of genetic mutations associated with the development of thyroid cancer, such as BRAF and RET, has lead to the development of new drugs which target the pathways which they influence. Despite recent advances, the prognosis of anaplastic thyroid carcinoma is still unfavourable. In this review we look at emerging novel therapies for the treatment of well-differentiated and medullary thyroid carcinoma, and advances and future directions in the management of anaplastic thyroid carcinoma.

  20. Mammary carcinoma diagnostics and therapy

    International Nuclear Information System (INIS)

    The book on mammary carcinoma diagnostics and therapy covers the following issues: development, anatomy and physiology of the mammary glands, pathology of benign and malign mammary gland changes, non-imaging diagnostics; mammography; ultrasonic mammography; magnetic resonance tomography of the mammary glands; imaging diagnostics findings; mammary interventions; examination concepts; operative therapy of the mammary carcinoma; chemotherapy of the mammary carcinoma; radio-oncological therapy of the mammary carcinoma; logistics in a medical center for mammary gland diseases; logistics in an interdisciplinary center for mammary diseases; dialogue conduction and psycho-social attendance.

  1. Perfil del visitante del parque nacional Desierto del Carmen

    OpenAIRE

    Elizabeth López Carré

    2007-01-01

    El artículo presenta los resultados obtenidos del proyecto de investigación titulado "Evaluación del potencial de comercialización y caracterización del visitante del Santo Desierto de Tenancingo", específicamente los correspondientes al perfil del visitante a dicho Parque Nacional. La metodología utilizada se sustenta en la investigación de mercados propuesta por Kinnear y Taylor. El resultado de dicha investigación permitió integrar el perfil del segmento de mercado religioso...

  2. Clinical parotid carcinoma analysis

    International Nuclear Information System (INIS)

    We clinically analyzed 48 consecutive retrospective cases of parotid carcinoma initially treated between 1988 and 2007. Subjects were 30 males and 18 females ranging from 5 to 85 years old (average: 57.9 years). Of the 12 histological types seen, the most common was mucoepidermoid carcinoma, seen in 12 subjects (25.0%). We studied their survival based on 5 potential prognostic factors-stage, T stage, neck metastasis, facial nerve palsy, and malignancy grade-together with features of mortality and recurrence. Overall 5-year disease-specific survival was 71.2% and 10-year survival 54.9%. Survival rates were significantly lower in stage IV and high-grade malignancy groups than in stage I-III and low-grade malignancy groups. T stage, neck metastasis, and facial nerve palsy tended to compromise survival. Recurrence developed in 2 subjects, in whom significant recurrence risk factors were stage III-IV (particularly, stage IV), T3-4, and high-grade malignancy. Of 18 deaths, causes were distant failure in 11 and local failure in 5. None died of nodal failure. Analysis of these prognostic factors is important in selecting appropriate surgery and in determining indications for postoperative radiotherapy and chemotherapy, leading to better treatment outcome in those with parotid carcinoma. (author)

  3. Glottic ansd supraglottic carcinoma

    International Nuclear Information System (INIS)

    From 1971 through 1982, 442 patients with laryngeal carcinoma were seen at the Leiden University Hospital. They were treated either with radiotherapy alone, sandwich therapy (pre- and postoperative radiotherapy) or by surgery followed by postoperative irradiation. Three hundred and sixty-six patients with glottic or supraglottic tumours could be analysed with respect to two different treatments, complications of treatment and some prognostic factors. Two endpoints of analysis were used: disease-free interval and survival to cfancer death. In patients with glottic or supraglottic carcinoma, the survival of patients with advanced disease, treated with radiotherapy only, was worse as compared to the survival of the same category of patients who were treated with sandwich therapy (p<0.005). In small supraglottic tumours, the survival with both therapy policies was equal. There was no influence on prognosis of histological differentiation of the tumour. It appeared that interruption of radiotherapy for more tah two days had an adverse effect on survival in patients with glottic carcinoma (p=0.0001). (author). 16 refs.; 4 figs.;

  4. Epidermoid carcinoma of the conjunctiva. Case report Carcinoma epidermoide de conjuntiva. Presentación de un caso

    Directory of Open Access Journals (Sweden)

    María Adela LLull Tombo

    2011-12-01

    Full Text Available

    The case of a 76 years old male patient with a conjunctival squamous cell carcinoma is presented. The main clinical manifestation was discomfort, pain and redness in the eye. Physical ocular examination revealed a whitish eye injury, with blood vessels in the inner corner, above the right eye pterygium. It was diagnosed as squamous cell carcinoma, which evolved rapidly and invasively. Due to recurrences, three surgeries were performed.

    Se presenta el caso de un paciente de 76 años de edad con un carcinoma epidermoide de conjuntiva.  La manifestación clínica principal fue la molestia, el dolor y el ojo rojo. Al examen físico ocular se encontró lesión blanquecina, con vasos sanguíneos en el ángulo interno, por encima del pterigion en ojo derecho. Se diagnosticó como carcinoma epidermoide de la conjuntiva, el cual evolucionó de forma rápida e invasiva. Se intervino quirúrgicamente en tres ocasiones debido a las recurrencias.

  5. Estudio de Rodilla Flotante en pacientes del Hospital Clinico Viedma

    Directory of Open Access Journals (Sweden)

    Omar Marcelo Vargas Fuentes

    2011-06-01

    Full Text Available Se denomina “Rodilla Flotante” a la combinación de fractura de fémur y tibia ipsilaterales. La incidencia exacta se desconoce, pero tiene un abordaje terapéutico complejo, una alta tasa de complicaciones y una elevada mortalidad.El presente estudio busca determinar los aspectos relacionados con esta patología en nuestro medio y analizarlos de una manera integral, realizándose para esto un estudio descriptivo y longitudinal retrospectivo abarcando 18 meses (de julio 2008 a diciembre 2009 que incluye a 17 pacientes con diagnóstico de “Rodilla Flotante” ingresados en el Servicio de Ortopedia y Traumatología del Hospital Clínico Viedma. Los resultados mostraronque esta lesión equivale al 1,9 % de los casos atendidos por este servicio. Siendo el 82,35% hombres. La edad promedio fue de 34 años. El mecanismo de producción más frecuente: accidentes en motocicleta (41,2%, seguido de atropellados (29,4%. En cuanto a la clasificación la mayor parte fue tipo I de Fraser (68,8%. El tratamiento quirúrgico definitivo se aplicó entre el 5° y 14° día en el 73.3%, mayormente usando clavos centro medulares en fémur y tibia. Los resultados del tratamiento fueron: excelentes 40%, buenos 33.3%, regulares 20% y pobres en el 6,6% según la escala de Karlstrom y Olerud. Las lesiones asociadas: TEC (80%, fracturas de pelvis (60%, trauma abdominal cerrado (60% y trauma de tórax (33,3%. Dentro de las complicaciones, un paciente falleció por fallamultiorgánica, otro concluyó en amputación, y cinco presentaron infección.Por lo que se concluye que en general los aspectos relacionados con esta patología, su presentación y tratamiento en nuestro medio, son similares a los que se encuentran descritos en la literatura médica.

  6. Carcinoma de células escamosas de cavidad bucal en un centro de tercer nivel de atención social en la ciudad de México: Experiencia de cinco años Oral cavity squamous cells carcinoma, 5 years experience in a third level social assistence center, in Mexico city

    OpenAIRE

    G. Meza García; J.J. Muñoz Ibarra; C. Páez Valencia; B. Cruz Legorreta; Aldape Barrios, B.

    2009-01-01

    El carcinoma epidermoide o de células escamosas, es una neoplasia maligna que se origina de las células escamosas del epitelio que recubre la mucosa, es la más frecuente de la cavidad bucal. Objetivo: determinar si la supervivencia y muerte de los pacientes con carcinoma epidermoide de cavidad bucal, asociada a la edad, género, factores de riesgo, grado histológico y tratamiento recibido. Método: Se revisaron los archivos del servicio de Anatomía Patológica del Centro Médico Nacional "20 de N...

  7. Viral hepatitis and hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Two papers in this volume are in INIS scope, respectively dealing with MRI in the study of viral hepatitis and hepatocellular carcinoma, and The use of 131I-labeled Lipidol in the diagnosis of hepato-cellular carcinoma. (H.W.). refs.; figs.; tabs

  8. Tubulocystic carcinoma of the kidney

    OpenAIRE

    Podduturi, Varsha; Adair, Carol F.; Zhang, Haiying

    2015-01-01

    Tubulocystic carcinoma (TCC) of the kidney is a unique, rare, and recently recognized neoplasm. Although originally considered a low-grade collecting duct carcinoma, TCC is now considered to be a distinct entity. TCC should be considered in the differential diagnosis of cystic renal neoplasms. We report a case of TCC arising in the left kidney.

  9. Caracterización biológica del adenocarcinoma lobulillar infiltrante de mama

    OpenAIRE

    Abellán Rosique, Beatriz

    2016-01-01

    El cáncer de mama constituye actualmente, la causa más frecuente de muerte por cáncer de los países desarrollados, en las mujeres entre 40 y 45 años. Actualmente presenta un aumento de la incidencia anual del 2%. El carcinoma lobulillar de mama (CL) es la segunda neoplasia más frecuente entre los carcinomas mamarios. Tradicionalmente se ha asociado a los mismos factores de riesgo que el carcinoma ductal y la misma etiopatogenia. Sin embargo se conocen la existencia de diferenci...

  10. PROGNOSTIC FACTORS IN CERVICAL CARCINOMA

    Institute of Scientific and Technical Information of China (English)

    路平; 梁秋冬; 魏磊; 郑全庆

    2002-01-01

    Objective: To evaluate factors for prognosis of cervical carcinoma. Methods: Expressions of mn23- HI, erbB3 and erbB4 were examined by immunohistochemical staining. The apoptosis was detected in situ by the TdT mediated duip-biotin nick end-labeling (TUNEL) technique. Mitotic cell were counted by HE dyeing. Results: FIGO stage and lymph node metastasis were the most important factors for evaluating prognosis in adenocarcinoma or squamous cell carcinoma. AI/MI was positively correlated with 5-year survival of cervical carcinoma. Positive expression of nm23-H1 combed with negative expression of erbB4 [nm23-H1(+)/erbB4(-)] predicted good prognosis for adeno-carcinoma. In multivariable Cox regression analysis, only FIGO stage and AI/MI were into equation. Conclusion: FIGO stage and AI/MI were independent evaluating parameter for adenocarcinoma or squamous cell carcinoma.

  11. Vitronectin in human breast carcinomas

    DEFF Research Database (Denmark)

    Aaboe, Mads; Offersen, Birgitte Vrou; Christensen, Anni;

    2003-01-01

    We have analysed the occurrence of the extracellular glycoprotein vitronectin in carcinomas and normal tissue of human breast. Immunohistochemical analysis of carcinomas revealed a strong vitronectin accumulation in extracellular matrix (ECM) around some cancer cell clusters and in the...... subendothelial area of some blood vessels. In normal tissue, vitronectin had a homogeneous periductal occurrence, with local accumulation much lower than that in the carcinomas. Using a new solid phase radioligand assay, the vitronectin concentrations of extracts of carcinomas and normal breast tissue were...... determined and found to be indistinguishable. Comparison of the vitronectin and the hemoglobin concentrations of the extracts showed that their vitronectin content was not derived from blood contamination. Vitronectin mRNA was undetectable in both carcinomas and normal tissue. We conclude that vitronectin is...

  12. Carcinoma de Células Escamosas de Tiroides: A Propósito de un Caso Primary squamous cell thyroid carcinoma

    Directory of Open Access Journals (Sweden)

    J. Rodríguez

    2010-12-01

    Full Text Available El carcinoma de células escamosas de tiroides (CCET es un tumor infrecuente y agresivo. Su etiología es incierta. Ante la presencia de carcinoma escamoso en la glándula tiroides debe excluirse la posibilidad de infiltración de un tumor originado en una estructura adyacente o de metástasis de otros carcinomas. El tratamiento de elección es la cirugía radical. La mayoría de los pacientes fallecen antes del año debido a progresión local de la enfermedad. Presentamos el caso de un paciente con una masa tiroidea, con diagnóstico histológico de carcinoma escamoso (con inmunohistoquímca negativa para tiroglobulina, TTF1 y calcitonina y positiva para p63 y citok5. Los estudios clínicos, endoscópicos y radiológicos excluyeron otros sitios de origen de carcinoma escamoso. Fue tratado con quimio y radioterapia, falleciendo por progresión local luego de 9 meses.Primary squamous cell thyroid carcinoma (PSCTC is a rare and aggressive tumor of uncertain origin. When squamous carcinoma is diagnosed, it is mandatory to exclude the possibility of primary tumor arising from an adjacent structure or representing metastases from a primary growth elsewhere. Aggressive surgical resection is the treatment of choice. However, the prognosis is poor, with a median survival of less than a year. Death is usually secondary to progression of local disease. We report a case of a patient presenting with a thyroid mass; biopsy was consistent with squamous cell carcinoma. On immunohistochemistry tumor cells were negative for TTF1, thyroglobulin and calcitonin. Cancer cells were positive for p63 and citok5. Extensive workup excluded the possibility of extrathyroid origin. The patient was treated with chemoradiotherapy; he died 9 months later due to local progression.

  13. Análise clínica e ultrassonográfica dos ombros de pacientes lesados medulares em programa de reabilitação Shoulders of patients with spinal cord injuriessubmited to rehabilitation program - a clinical and ultrasound-based assessment

    Directory of Open Access Journals (Sweden)

    André Felipe Ninomyia

    2007-01-01

    Full Text Available O aumento da incidência de traumas de alta energia esta relacionado com o crescimento da prevalência de lesões raquimedulares ocasionando seqüelas motoras nos membros. O programa de reabilitação proporciona perspectiva de melhora da qualidade de vida, colaborando para a reintegração social desses indivíduos. As síndromes dolorosas dos ombros são freqüentes nos pacientes lesados medulares, independentemente do programa de reabilitação adotado. No presente estudo, avaliou-se por meio da ultrassonografia, 32 ombros de 16 pacientes com lesão medular com localização anatômica entre C4 e T12, em reabilitação no DOT/HC-UNICAMP, constatando-se alterações nos tendões dos músculos do manguito rotador em 46,88% e nas tuberosidades umerais em 12,50% dos pacientes estudados. As alterações foram mais prevalentes entre os tetraplégicos. A execução de medidas analgésicas, fortalecimento dos músculos do manguito rotador quando possível e alterações posturais podem significar diminuição na ocorrência das síndromes dolorosas dos ombros, melhorando o aproveitamento do programa de reabilitação e com ganhos na qualidade de vida.The increasing incidence of high energy traumas is associated to a growing prevalence of spinal cord injuries causing motor sequels on limbs. Rehabilitation programs provide an opportunity for improvement of quality of life, helping on integrating those individuals back into social activities. Shoulder pain is more frequent in individuals with spinal cord injury, regardless of the rehabilitation program adopted. In the current study, 32 shoulders of 16 patients with spinal cord injury levels between C4 and T12 submitted to a rehabilitation program at DOT/UNICAMP were evaluated by using ultrasound. Changes on rotator cuff tendons were detected in 56.25%, and 12.50% of the patients presented changes in humeral tuberosities. These changes were more prevalent in quadriplegic patients. Analgesic therapies

  14. Diagnóstico diferencial das lesões inflamatórias e infecciosas do cone medular utilizando a ressonância magnética Magnetic resonance imaging in the differential diagnosis of infectious and inflammatory conus medullaris lesions

    Directory of Open Access Journals (Sweden)

    Gustavo Balthazar da Silveira Carvalho

    2013-02-01

    Full Text Available O cone medular é frequentemente acometido por lesões de etiologia inflamatória e infecciosa, muitas vezes de difícil diferenciação devido a história clínica e exame físico semelhantes entre as diversas entidades. A ressonância magnética apresenta alta sensibilidade na detecção de lesões no cone medular e tem importante papel no diagnóstico e controle evolutivo. Este ensaio iconográfico com casos selecionados dos arquivos do nosso serviço tem como objetivo demonstrar achados de imagem que possam auxiliar no diagnóstico de uma etiologia específica entre as doenças inflamatórias e infecciosas e na diferenciação com doenças de outras etiologias como neoplasias e causas vasculares. Características como padrão de realce, presença de cistos, edema, além do acometimento de outras regiões do sistema nervoso central são importantes para esta diferenciação, podendo definir uma etiologia específica quando associadas ao quadro clínico e laboratorial.The conus medullaris is frequently affected by inflammatory and infectious lesions which many times are hardly differentiated because of the similarity of their clinical history and physical examination among the different etiologies. Magnetic resonance imaging presents high sensitivity in the detection of these lesions and plays a relevant role in the diagnosis as well as in the evolutive control of the condition. The present pictorial essay with selected cases from the archives of the authors' institution is aimed at demonstrating imaging findings which might help in the diagnosis of a specific etiology amongst inflammatory an infectious conditions and in the differentiation with diseases of neoplastic and vascular etiologies, for example. Findings such as enhancement pattern, presence of cysts, edema and involvement of other regions of the central nervous system are important for this differentiation, and may define a specific etiology as associated with clinical and

  15. Metastatic paediatric colorectal carcinoma.

    LENUS (Irish Health Repository)

    Woods, R

    2012-03-01

    A 16-year-old girl presented to our unit with crampy abdominal pain, change in bowel habit, a subjective impression of weight loss and a single episode of haematochezia. She was found to have a rectosigmoid adenocarcinoma and proceeded to laparoscopic anterior resection, whereupon peritoneal metastases were discovered. She received chemotherapy and is alive and well ten month later with no radiological evidence of disease. Colorectal carcinoma is rare in the paediatric population but is increasing in incidence. Early diagnosis is critical to enable optimal outcomes.

  16. Carcinoma of the thyroid

    International Nuclear Information System (INIS)

    Reference is made to the diagnostic evaluation of thyroid nodule, reaffirming the concepts of algorithm study, sensitivity and specificity of diagnostic procedures and cost-effectiveness. Stressing once again the place of cytology and the concept of selecting patients for surgery, surgical tactics in front of the thyroid nodule and the need for probate multidisciplinary study and treatment of this pathology. Briefly discusses the most controversial treatment of differentiated thyroid carcinomas, the sine qua non of the pathologist in the operating room in thyroid surgery and the value of the quantification of nuclear DNA in the diagnosis and prognosis of these tumors (Author)

  17. Penis squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Leonor Hernández Piñero

    2015-09-01

    Full Text Available Cancer has become a first order health problem worldwide, despite the great diagnostic and therapeutic programs achieved during the last years. This is a clinical case of an 81- year-old patient with personal and social history of promiscuous and unprotected sexual behavior that shows a vegetative lesion in his gland and numerous inguinal adenopathies. Biopsy confirms the diagnosis of squamous cell carcinoma infiltrating the penis, which is a relatively rare pathology which is generally diagnosed belatedly. Partial amputation of the penis was considered to be performed, but there was no consent on behalf of his family. The patient’s general condition was getting worse until he died.

  18. Radiotherapy of corpus carcinoma

    International Nuclear Information System (INIS)

    96 women with primary carcinoma corporis uteri and 79 women after surgery were treated between 1965 - 1970 with different radiotherapeutic methods, in some cases in combination with cytostatics and gestagens. In the group of primary radiation best results were obtained with combination of intracavitary brachytherapy and external radiation (55% 5-years-survival), and in the postoperative group with external radiation alone (67% 5-years-survival). Late complications with 17% fibrosis in the parametrial tissue and 12% persistant diarrhea in the postoperative group needs strict individualization in therapy and requires exact knowledge on extention and biological behavior of the tumor. (author)

  19. Carcinoma of the penis

    International Nuclear Information System (INIS)

    Forty-four patients with squamous cell carcinoma of the penis stage T1-T2, N0 were either treated surgically (n=19) or with a combination of irradiation and bleomycin (n=25). The overall actuarial survival rate was 80% at 3 years, 77% at 5 years and 60% at 10 years. The result of irradiation treatment combined with bleomycin was in stage N0 equivalent to that of surgical therapy. The non-surgical treatment had the advantage of preserved sexual ability. (orig.)

  20. Laryngeal carcinoma. I

    International Nuclear Information System (INIS)

    A series of 359 patients with carcinoma of the larynx was found to be very close to being representative of the northern part of Jutland, Denmark (north of Kongeaen). No unequivocal change in the disease as regards sex, age, histology, symptoms and signs, and stage of disease could be observed during the period 1963 to 1972. A not statistically significant improvement in the corrected mortality appeared. The level of complications after irradiation and secondary surgery was found to be low. A statistically significant, better prognosis was found for females than for males in the glottic group. (Auth.)

  1. Chemoradiotherapy in pancreatic carcinoma

    Directory of Open Access Journals (Sweden)

    Pathy Sushmita

    2009-01-01

    Full Text Available Pancreatic cancer patients present late in their course and surgical resection as a modality of treatment is of limited value. Majority develop loco-regional failure and distant metastasis, therefore, adjuvant therapy comprising of radiotherapy and chemotherapy are useful treatment options to achieve higher loco-regional control. Specialized irradiation techniques like intra-operative radiotherapy that help to increase the total tumor dose have been used, however, controvertible survival benefit was observed. Various studies have shown improved median and overall survival with chemoradiotherapy for advanced unresectable pancreatic carcinoma. The role of new agents such as topoisomerase I inhibitors also needs further clinical investigations.

  2. Surveillance for Hepatocellular Carcinoma

    OpenAIRE

    Ramachandran, Jeyamani

    2014-01-01

    Hepatocellular carcinoma (HCC) is a dreaded complication of cirrhosis as it is the commonest cause of mortality in these patients. The last few years have seen a dramatic improvement in the management of this tumor as nearly 50–70% of selected patients with early HCC survive for a median period of up to 5 years after liver transplantation, resection or local ablation. Surveillance has been found to be an effective tool to detect early tumors and expand the applicability of these curative trea...

  3. Verrucous carcinoma of the maxillary antrum

    OpenAIRE

    Vaid, Neelam; Nagare, Sachin

    2003-01-01

    Verrucous carcinoma is a well-differentiated variant of squumous cell carcinoma. In this article, we present a patient of verrucous carcinoma of the maxillary annum. There are only 6 reported cases of verrucous carcinoma of the maxillary antrum. Ours is the 7th case. We, here, would like to highlight that our case had a different clinical presentation from the previously reported cases.

  4. Composite encapsulated papillary carcinoma and solid papillary carcinoma.

    Science.gov (United States)

    Cui, Xiaoyan; Wei, Shi

    2015-03-01

    Encapsulated papillary carcinoma (EPC) and solid papillary carcinoma (SPC) are distinctive variants of intraductal papillary carcinomas, each accounting for breast carcinomas. Here we report a composite carcinoma consisting of EPC and SPC. A 73-year-old woman was found to have a high density mass in the left breast on mammogram. A biopsy showed intermediate to high grade ductal carcinoma in situ (DCIS). Gross examination of the lumpectomy specimen revealed a solid, multinodular mass. Microscopic examination demonstrated two morphologically distinct intraductal carcinomas intermingled with each other. One had delicate papillae in multi-cystic spaces surrounded by thick fibrous capsule, consistent with EPC. The other had solid tumor nests with delicate fibrovascular cores. The cells were monotonous with round nuclei and salt and pepper-like chromatin, characteristic of SPC. The lack of myoepithelial cells within the papillae and at the periphery of the lesion was confirmed by immunostaining for p63 and CK5/6. Neuroendocrine differentiation of SPC was demonstrated by neuron specific enolase staining. To our knowledge, this is the first reported case of composite EPC and SPC. It raises an interesting question as to a possible common pathway of carcinogenesis of these two rare variants. PMID:25545718

  5. Carcinoma adenoide quístico de seno esfenoidal

    OpenAIRE

    Fuente Cañibano, Rebeca de la; Muñoz Herrera, Ángel María

    2012-01-01

    [ES] El carcinoma adenoideo quístico (CAQ) es un tumor epitelial maligno de glándulas salivales, que por lo general da metástasis tardíamente, pero es persistente y muy agresivo debido a su gran capacidad de infiltrar tejido adyacente y fibras nerviosas. El CAQ de senos paranasales puede diseminarse siguiendo el trayecto de los nervios craneales; su relación cercana con estructuras vitales, impide la resección completa del tumor quedando márgenes positivos hasta en un 80% de los pacientes, pr...

  6. Carcinoma tricofolicular con capacidad metastásica

    OpenAIRE

    C.B. Pinilla-Martínez; J.M. Lasso-Vázquez; R. García-Leal; Salinero-Paniagua, E; Pérez-Cano, R.

    2015-01-01

    El carcinoma folicular es un tumor maligno derivado del folículo piloso. La mayor parte de los tumores foliculares son benignos, pero en los últimos años se han publicado casos aislados de tumores anexiales con características de malignidad y con una gran agresividad local siendo en principio tumores que se consideraban benignos. Creemos que este tumor está siendo infradiagnosticado, y como consecuencia, infratratado al ser confundido con otros tumores malignos originados en la piel, como el ...

  7. La tomografía axial computarizada como herramienta para el diagnóstico y la planificación quirúrgica de la compresión medular

    OpenAIRE

    Delgado Stagnares, Juan Jose; Portiansky, Enrique Leo; Sánchez, Hilda Liliana

    2015-01-01

    La hernia discal es la causa más frecuente de lesión de la médula espinal en caninos. El 85 % de los casos se produce en la región toracolumbar. El Dachshund es una de las razas más susceptibles, debido a factores hereditarios. Desde el punto de vista anatómico, la lesión se localiza, principalmente, entre los espacios intervertebrales T11-T12 hasta L1-L2 y se asocia con la degeneración del núcleo pulposo del disco intervertebral, lo cual produce una extrusión o una protrusión. Las alterac...

  8. Carcinoma of the cervix

    International Nuclear Information System (INIS)

    Purpose: To discuss a variety of technical and clinical issues concerning the management of carcinoma of the uterine cervix. Radiation therapy plays a central role in the management of patients with invasive carcinoma of the uterine cervix. Although survival rates are high for patients with small volume disease, clinicians continue to search for approaches that might improve treatment results for patients who have bulky central disease, evidence of regional dissemination or other factors associated with a high rate of disease recurrence. New technical approaches have contributed to controversy about the best means of optimizing therapeutic ratio. This course will review current approaches to the management of cervical cancer. Technical aspects of intracavitary and external beam treatment will be emphasized. Problems with brachytherapy dose specification will be discussed as will technical factors that may influence the incidence of treatment-related complications. Current understanding of the natural history of disease and of clinical factors that influence the rate of disease recurrence will be reviewed, including the importance of tumor volume, lymph node involvement, and histologic type on natural history and prognosis. The possible role of controversial methods of clinical evaluation such as lymphangiography and surgical staging will be discussed. Some of the more controversial aspects of treatment including the indications of radiation therapy vs. surgical therapy for stage IB disease, the role of extended field therapy, postoperative therapy, adjuvant hysterectomy, and neoadjuvant or concurrent chemotherapy will be discussed. Conclusions from the recent NCI consensus conference on cervical cancer will be reviewed

  9. Carcinoma of the cervix

    International Nuclear Information System (INIS)

    Purpose: To discuss a variety of technical and clinical issues concerning the management of carcinoma of the uterine cervix. Radiation therapy plays a central role in the management of patients with invasive carcinoma of the uterine cervix. Although survival rates are high for patients with small volume disease, clinicians continue to search for approaches that might improve treatment results for patients who have bulky central disease, evidence of regional dissemination or other factors associated with a high rate of disease recurrence. New technical approaches have contributed to controversy about the best means of optimizing therapeutic ratio. This course will review current approaches to the management of cervical cancer. Technical aspects of intracavitary and external beam treatment will be emphasized. Problems with brachytherapy dose specification will be discussed as will technical factors that may influence the incidence of treatment-related complications. Current understanding of the natural history of disease and of clinical factors that influence the rate of disease recurrence will be reviewed, including the importance of tumor volume, lymph node involvement, and histologic type on natural history and prognosis. The possible role of controversial methods of clinical evaluation such as lymphangiography and surgical staging will be discussed. Some of the more controversial aspects of treatment such as the indications for radiation therapy vs. surgical therapy for stage IB disease, the role of extended field therapy, postoperative therapy, adjuvant hysterectomy and neoadjuvant or concurrent chemotherapy will be reviewed

  10. EVALUACIÓN HISTOLÓGICA DE BIOCOMPATIBILIDAD Y BIOCONDUCCIÓN DEL COMPUESTO HIDROXIAPATITA - LIGNINA IMPLANTADO EN TIBIA DE CONEJOS

    Directory of Open Access Journals (Sweden)

    Marlene Vargas V

    2009-04-01

    Full Text Available Objetivo. Evaluar histologicamente la biocompatibilidad y propiedad óseoconductora del compuesto de hidroxiapatita - lignina implantado en tibias de conejos. Material y métodos. Se utilizaron 20 conejos de raza nueva Zelanda, en cada uno, la tibia izquierda fue tratada con el compuesto y la tibia derecha no fue tratada y sirvió como control. Con la ayuda de taladro manual y una broca se realizó un defecto óseo de aproximadamente 4 mm de diámetro en la superficie lateral proximal tibial, hasta alcanzar el canal medular. Dos comprimidos del compuesto (400 mg, se utilizaron para rellenar el defecto. El mismo procedimiento quirúrgico se realizó en el grupo control, sin la utilización del compuesto. Las evaluaciones histológicas se realizaron a los 8, 30, 60, 90 y 120 días postcirugía, para lo que fue necesaria la eutanasia de 4 animales por fecha de evaluación. Resultados. En las evaluaciones de 30, 60, 90 y 120 días se observó una formación ósea más acelerada y extensa en el grupo tratado al compararse las lecturas histológicas con el grupo control. Conclusiones. El compuesto hidroxiapatita-lignina permitió el crecimiento de tejido óseo desde los bordes hasta el centro del defecto a un ritmo de crecimiento mayor, con formación de hueso mas organizado que en el grupo control. Además se observó su integración al tejido óseo; lo que sugiere su biocompatibilidad y propiedad óseoconductora, hecho que permite recomendarlo como substituto.

  11. Pulmonary Metastasis of Basal Cell Carcinoma

    OpenAIRE

    Seo, Sang-Hee; Shim, Woo-Haing; SHIN, DONG-HOON; Kim, Yun-Seong; Sung, Hyun-Woo

    2011-01-01

    Although basal cell carcinoma is the most common skin cancer, it rarely metastasizes. Metastatic basal cell carcinoma may, therefore, initially elude diagnosis and management. We describe the case of a patient with a metastatic basal cell carcinoma present in the lungs. The differential diagnosis of suspected metastatic lesions should include metastases from a cutaneous basal cell carcinoma, in addition to those from more commonly metastasizing carcinomas, especially in patients with a histor...

  12. Imaging of cholangio-carcinoma

    International Nuclear Information System (INIS)

    Cholangio-carcinoma is an uncommon biliary duct tumor. Two types of cholangio-carcinomas exist: peripheral intrahepatic cholangio-carcinoma (IHC) or cholangio-cellular carcinoma, which originates from small biliary ducts and extrahepatic cholangio-carcinoma (EHC) which originates from a main hepatic duct, from the bifurcation of the common hepatic duct or from the main bile duct. Clinically and radiologically, these two types of cholangio-carcinomas differ. IHC is an intrahepatic focal mass. Features suggestive of the diagnosis can be shown by sonography, CT and MR imaging but only the biopsy affirms the kind of the tumor. Cholangiography and arteriography have also a role in the preoperative staging. The EHC, more common, often appears as a dilatation of intrahepatic bile ducts without any mass. Features suggestive of the diagnosis can be shown by sonography, Ct and MR imaging but only the biopsy affirms the kind of the tumor. Cholangiography and arteriography have also a role in the preoperative staging. The EHC, more common, often appears as a dilatation of intrahepatic bile ducts without any mass. If sonography, CT, MR imaging, Cholangio MR imaging and/or direct cholangiography suggest the diagnosis, the major issue of imaging is to determine whether the tumor is resectable. Hilar cholangio-carcinoma rapidly involves local vessels. Venous or arterial involvement must be depicted by arteriography before surgery. (authors)

  13. Metastatic basal cell carcinoma caused by carcinoma misdiagnosed as acne - case report and literature review.

    Science.gov (United States)

    Aydin, Dogu; Hölmich, Lisbet Rosenkrantz; Jakobsen, Linda P

    2016-06-01

    Basal cell carcinoma can be misdiagnosed as acne; thus, carcinoma should be considered in treatment-resistant acne. Although rare, neglected basal cell carcinoma increases the risk of metastasis. PMID:27398205

  14. Metastatic basal cell carcinoma caused by carcinoma misdiagnosed as acne – case report and literature review

    OpenAIRE

    Aydin, Dogu; Hölmich, Lisbet Rosenkrantz; Jakobsen, Linda P.

    2016-01-01

    Key Clinical Message Basal cell carcinoma can be misdiagnosed as acne; thus, carcinoma should be considered in treatment‐resistant acne. Although rare, neglected basal cell carcinoma increases the risk of metastasis.

  15. Carcinoma basocelular metastásico en la región parotídea: un nuevo caso Basal cell carcinoma metastatic to the parotid area: case report

    OpenAIRE

    T. Pérez de la Fuente; I. González González

    2006-01-01

    El carcinoma basocelular es la tumoración cutánea maligna más frecuente. Junto con el carcinoma espinocelular su localización habitual es a nivel de cabeza y cuello y a diferencia de éste la tasa de metástasis regionales es mucho más baja. Presentamos el caso de una mujer de 85 años con un carcinoma basocelular a nivel del pabellón auricular derecho, que inicialmente se trató mediante extirpación y cierre. A los 2 años presentó recidiva local en la zona inferior del pabellón auricular y en la...

  16. Bronchial mucoepidermoid carcinoma: CT findings

    International Nuclear Information System (INIS)

    Mucoepidermoid carcinoma of the bronchus is an extremely rare tracheobronchial neoplasm arising in the bronchial submucosal glands that shows an intimate admixture of glandular elements and sheets of cells with little or no definite squamous differentiation. We report 2 cases of mucoepidermoid carcinoma of the bronchus found in a 15-year-old boy and a 59-year-old woman. CT scans revealed a well-marginated, exophytic, endobronchial, polypoid soft tissue mass. Bronchial mucoepidermoid carcinoma should be included in the differential diagnosis of endobronchial tumors in young patients and non-smokers

  17. Bronchial mucoepidermoid carcinoma: CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun; Kang, Si Won; Ahn, Kuk Jin; Bahk, Yong Whee [Daejeon St. Mary' s Hospital, Catholic University Medical Colleg, Daejeon (Korea, Republic of)

    1991-03-15

    Mucoepidermoid carcinoma of the bronchus is an extremely rare tracheobronchial neoplasm arising in the bronchial submucosal glands that shows an intimate admixture of glandular elements and sheets of cells with little or no definite squamous differentiation. We report 2 cases of mucoepidermoid carcinoma of the bronchus found in a 15-year-old boy and a 59-year-old woman. CT scans revealed a well-marginated, exophytic, endobronchial, polypoid soft tissue mass. Bronchial mucoepidermoid carcinoma should be included in the differential diagnosis of endobronchial tumors in young patients and non-smokers.

  18. El dibujo como primera escritura del niño

    Directory of Open Access Journals (Sweden)

    María del Rosario Vargas León

    2004-08-01

    Full Text Available Resumen. En el siguiente trabajo, se aborda un aspecto muy poco tomado en cuenta en el proceso de enseñanza y aprendizaje de la lectura y la escritura, como lo es la simbolización gráfica o dibujo del niño. Diversas investigaciones a nivel internacional y nacional demuestran que el dibujo por ser un componente de la génesis del niño, se constituye en un aspecto medular en la construcción que él realiza de su lectura y escritura inicial. El niño puede convertir el dibujo en un sistema de comunicación muy efectivo. El proceso creativo que lo lleva a enfrentar constantemente conflictos cognitivos para inventar y reinventar formas de expresión cada vez más comunicativas lo irá preparando para entender y comprender mejor el sistema alfabético convencional que su medio cultural y social le impone. La experiencia realizada en dos escuelas costarricenses, desde el Proyecto de Extensión Implementación de una didáctica constructivista en los procesos iniciales de la lectura y escritura, de la División de educación Básica del CIDE, de la Universidad Nacional, ha demostrado que al tomar en cuenta la génesis de la construcción del conocimiento del niño, respeta y promueve sus formas de expresión simbólica hace el aprendizaje de la lectura y escritura sea más significativo para el niño.   Abstract. Article that addresses a little explored aspect in the teaching and learning of reading and writing, that is, graphic symbols or drawings made by children. Several national and international investigations have shown that since drawings are part of a child's genesis, they constitute a crucial aspect in his first construction of reading and writing skills. A child can turn drawings into a very effective system of communication. The creating process that constantly makes him face cognitive conflicts that require him to invent and reinvent progressively more communicative ways of expression will prepare him to better understand the

  19. del cambio

    Directory of Open Access Journals (Sweden)

    Alejandro Canales

    2006-01-01

    Full Text Available El artículo analiza las propuestas y los compromisos en materia de cobertura y de financiamiento en el periodo 2000-2006. En particular, revisa las modificaciones y los ajustes de los tres principales documentos en los que se expresaron las iniciativas: el de la Asociación Nacional de Universidades e Instituciones de Educación Superior, el del equipo de la transición y el programa sectorial. Los resultados muestran que las cifras de atención a la demanda educativa e inversión quedaron lejos de las metas autoimpuestas por el gobierno federal y que será necesario realizar mayores esfuerzos para atender tales desafíos.

  20. Carcinoma triquilemal: relato de caso Trichilemmal carcinoma: case report

    Directory of Open Access Journals (Sweden)

    Miguel Roismann

    2011-10-01

    Full Text Available O carcinoma triquilemal é um tumor raro, que ocorre, geralmente, na pele exposta ao sol, principalmente face, couro cabeludo, pescoço e dorso das mãos, em indivíduos idosos, entre a 4ª e 9ª décadas de vida, sem predilação por sexo. O presente estudo mostra um caso de carcinoma triquilemal, recidivado, de difícil tratamento, em mesma topografia de um carcinoma basocelular tratado previamente com cirurgia e radioterapia.The trichilemmal carcinoma is a rare tumor that usually occurs on sun-exposed skin, especially on the face, scalp, neck and back of hands, mainly in elderly subjects but commonly between the 4th and 9th decades of life. It is not a gender-based illness. This study shows a difficult to treat case of recurrent trichilemmal carcinoma on the same location of a basal-cell carcinoma previously treated with surgery and radiotherapy.

  1. Carcinoma of the vulva

    International Nuclear Information System (INIS)

    The accepted primary treatment modality in carcinoma of the vulva is a surgical resection. The standard approach is a radical vulvectomy with superficial nodal dissections if the superficial ignuinal nodes are involved. Surgical treatment is associated with a substantial incidence of local recurrence and significant morbidity predominantly associated with nodal dissection. Definitive radiation therapy is a viable alternative to surgery; with it, an overall 5-year survival of 40% to 50% can be expected. The incidence of sequelae with definitive radiation therapy appears acceptable, and is conceivable that it might be reduced substantially if modern techniques and time-dose schemes are applied. A promising area for radiation therapy is in combination with surgery

  2. Carcinoma of the penis

    International Nuclear Information System (INIS)

    Seventy-eight patients with carcinoma of the penis treated over a period of twelve years (1972-1983) were retrospectively analyzed. According to Jackson's clinical staging, 18.0% were in stage I, 20.5 in stage II, 26.9 in stage III, and 34.6% in stage IV. Some early-stage patients (12 with stage I and 4 with stage II) were primarily treated by external irradiation to a dose of 55 Gy/5 week/25 fr. Thirteen of these 16 patients had local control with preservation of the organ. The remaining patients with stage II were treated by partial or total penectomy. In stage III penectomy with inguiopelvic lymph node dissection was done. Stage IV patients received palliative irradiation and/or chemotherapy. There years' disease-free survival (including salvage surgery) was 93% in stage I, 62.5% in stage II and 38% in stage III. (orig.)

  3. Radiotherapic procedures in vulvar carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Cintra e Oliveira, V. (Hospital dos Servidores Publicos de Sao Paulo (Brazil); Instituto de Radioterapia de Sao Paulo (Brazil)); Lima, G.R. de (Escola Paulista de Medicina, Sao Paulo (Brazil); Hospital dos Servidores Publicos de Sao Paulo (Brazil)); Peres, O. (Instituto de Radioterapia de Sao Paulo (Brazil))

    The cases of six patients with vulvar squamous carcinoma are discussed. The radiotherapic procedure employed in the treatment is presented and compared to other methods. The small morbidity of the therapeutic procedure followed is commented.

  4. Renal cell carcinoma in childhood

    International Nuclear Information System (INIS)

    The authors present five cases of renal cell carcinoma in children, describing its aspects on excretory urography, ultra-sonography and computerized tomography. The clinical, pathological and radiological features are compared with those of the literature. (author)

  5. Oncofetal fibronectins in oral carcinomas

    DEFF Research Database (Denmark)

    Mandel, U; Gaggero, B; Reibel, J;

    1994-01-01

    -B-containing isoform and the oncofetal FN isoform derived by O-glycosylation, in oral squamous cell carcinomas, premalignant lesions, and normal oral mucosa. A selective expression of the ED-B-containing isoform was demonstrated in close relation to the invading carcinoma (38/38), whereas there was virtually no...... staining in submucosa underlying premalignant lesions (1/11) and normal epithelium (0/5). The ED-B-containing FN showed close co-distribution and staining pattern with the oncofetal isoform derived by O-glycosylation. These results demonstrate that accumulation of FN adjacent to oral carcinomas includes...... both the ED-B-containing isoform and the isoform derived by O-glycosylation. Although both the change in primary structure and glycosylation of FN create conformational and immunologically detectable changes, the functional consequences in association with invasive carcinoma are poorly understood at...

  6. Molecular pathology of breast apocrine carcinomas

    DEFF Research Database (Denmark)

    Celis, J.E.; Gromova, I.; Gromov, P.;

    2006-01-01

    Breast cancer is a heterogeneous disease that encompasses a wide range of histopathological types including: invasive ductal carcinoma, lobular carcinoma, medullary carcinoma, mucinous carcinoma, tubular carcinoma, and apocrine carcinoma among others. Pure apocrine carcinomas represent about 0...... between benign apocrine changes and breast carcinoma is unclear and has been a matter of discussion for many years. Recent proteome expression profiling studies of breast apocrine macrocysts, normal breast tissue, and breast tumours have identified specific apocrine biomarkers [15-hydroxyprostaglandin...... dehydrogenase (15-PGDH) and hydroxymethylglutaryl coenzyme A reductase (HMG-CoA reductase)] present in early and advanced apocrine lesions. These biomarkers in combination with proteins found to be characteristically upregulated in pure apocrine carcinomas (psoriasin, S100A9, and p53) provide a protein...

  7. [Bronchial mucoepidermoid carcinoma].

    Science.gov (United States)

    Bregante, J I; Rituerto, B; Font de Mora, F; Alonso, F; Andreu, M J; Figuerola, J; Mulet, J F

    1998-07-01

    We submit the case of a child afflicted with a mucoepidermoid bronchial tumor. The patient is a boy, aged seven, who after undergoing antibiotic treatment for six weeks because of a fever and atelectasia-condensation in the right lower lobe showed no signs of clinical improvement and was sent to our department to undergo further study and treatment. A bronchoscopy performed shows a polypoid mass that partially blocks the main bronchial tube a few milimiters under the access to the right upper lobe. A biopsy is carried out and the anatomopathological test shows there is a low degree epidermoid carcinoma. We decide to perform a lobectomy which for the tumor location and the lung condition has to be medium and lower right. We proceed to remove the adenopaty of hilium not affected by the tumor. The postoperative period develops without incidents. A check-up bronchoscopy performed three months later shows two polypoid masses in the right bronchial tube which, once a biopsy is performed, proved to be granulation tissue. Twelve months after undergoing surgery, the patient's condition is good, there is no evidence of tumor relapse and the breathing capacity is adequate, though there is an obstructive restrictive pattern in the espirometry. Even taking into consideration that lung tumors are extremely unusual, the epidermoid carcinoma is the one which most frequently occurs. The tumor's low malignancy is a sign that points to a good prognosis. Performing conservative surgery by means of bronchoplasty should be taken into account so as to keep the sequelae on the lung condition to a minimum, even though in this case the tumor location made it impossible. PMID:12602035

  8. New treatments for renal carcinoma

    OpenAIRE

    Perez-Gracia, J L; Lopez-Picazo, J M; Olier, C. (Clara); ALFARO, C.; Garcia-Foncillas, J; Melero, I; Gurpide, A

    2007-01-01

    Renal cell carcinoma presents several unique features, which distinguish it from other tumours. The increase in survival that has been described in patients with renal cell carcinoma following nephrectomy breaks a classical rule of oncology, which states that surgery of the primary tumour has no role in the treatment of patients with advanced disease. Together with melanoma, it is the only tumour in which immunomodulatory treatments with drugs such as interleukin-2 produces a clinical benefit...

  9. Radiosensitivity of carcinoma of esophagus

    International Nuclear Information System (INIS)

    With a detailed graphic reconstruction of radiation effects shown in 11 operation materials of carcinoma of esophagus with preoperative irradiation, histologic analysis of the radiosensitivity was made. Residual cancer lesions in 11 operation specimens contained adenocarcinoma elements. Carcinoma of esophagus belonged to mixed carcinoma (syn. metaplastic cancer). Radioresistant nature resulted from the remnant adenocarcinoma elements. Protruded type (3 cases) showed about 60 % of residual cancer after preoperative irradiation of 40 Gy (Lineac or 60Co.). The residual cancer nests histologically revealed well-differentiated squamous cell carcinoma with a few signet-ring cells, compatible with mucoepidermoid carcinoma. In protruded type, the mixed carcinoma was composed of segmental, disproportioned zonal squamous metaplasia. As its histogenetic origin, a main duct of esophageal gland was suggested. In 9 autopsy cases of esophageal cancer, recurrent lesion within the field of irradiation failed to respond to radiotherapy. In recurrent residual lesions, a higher proportion of adenocarcinoma elements was noticed. Therefore, the cancer part formed by a high rate of metaplasia was markedly responsive to irradiation, whereas increased residue of adenocarcinoma elements was enhanced the radioresistant property. In a middle thoracic esophagus (Im) corresponding to the commonest site of esophageal cancer, the distribution of esohageal glands was in a high density with a constant ratio of density in each age group particularly in male. In age groups with higher incidence of carcinoma of esophagus, esophageal glands markedly increased especially in male, in contrast with the indefinite number and density ratio in female cases. A high density of esophageal glands was noticed in the upper (Iu) and lower (Im) parts of the 2nd physiologic constriction, in proportion to the commonest site of carcinoma of esophagus. (J.P.N.)

  10. Genomic profile of ovarian carcinomas

    OpenAIRE

    Micci, Francesca; Haugom, Lisbeth; Vera M. Abeler; Davidson, Ben; Tropé, Claes G; Heim, Sverre

    2014-01-01

    Background It is known that all tumors studied in sufficient number to draw conclusions show characteristic/specific chromosomal rearrangements, and the identification of these chromosomes and the genes rearranged behind the aberrations may ultimately lead to a tailor-made therapy for each cancer patient. Knowledge about the acquired genomic aberrations of ovarian carcinomas is still unsatisfactory. Methods We cytogenetically analyzed 110 new cases of ovarian carcinoma of different histologic...

  11. Manejo conservador de una fistula de quilo por diseción radical de cuello: reporte de un caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    E Brenes Leñero

    2015-12-01

    Full Text Available Se expone el caso de un paciente masculino de 59 años con diagnóstico de carcinoma medular de tiroides con metástasis ganglionares, al cual se le realiza una tiroidectomía total bilateral con disección radical de cuello modificada tipo III. En el postoperatorio se documenta fístula del conducto torácico. Se dio un manejo conservador con dieta hiperprotéica sin carbohidratos y rica en triglicéridos de cadena media el cual fue satisfactorio.

  12. Manejo conservador de una fistula de quilo por diseción radical de cuello: reporte de un caso y revisión de la literatura

    OpenAIRE

    E Brenes Leñero; M Murillo Ceciliano; E Mora Segura

    2015-01-01

    Se expone el caso de un paciente masculino de 59 años con diagnóstico de carcinoma medular de tiroides con metástasis ganglionares, al cual se le realiza una tiroidectomía total bilateral con disección radical de cuello modificada tipo III. En el postoperatorio se documenta fístula del conducto torácico. Se dio un manejo conservador con dieta hiperprotéica sin carbohidratos y rica en triglicéridos de cadena media el cual fue satisfactorio.

  13. Ultrasonographic Findings of Gallbladder Carcinoma

    International Nuclear Information System (INIS)

    The gallbladder carcinoma accounts for 1.9% of all cancer and occurs predominantly in women over 50 years of age. As a rule, it may not be detected until the lesion has become quite large and has extended to adjacent structures. Ultrasonography is a direct imaging procedure which is widely used for the diagnosis of gallbladder carcinoma. Authors analyzed sonographic findings of 24 patients with gallbladder carcinoma diagnosed at the Department of Radiology, Kangnam St. Mary's Hospital, Catholic University Medical College during the past 5 years. 1. The gallbladder carcinoma was most prevalent in the sixth decade of life with equal ration of male to female patients. 2. The ultrasonographic findings of gallbladder carcinoma were classified into four types. The mass filling or replacing the gallbladder type was seen in 11 cases(46%), the thickened gallbladder-wall type in 6 cases (25%), fungation mass type in 4 cases(17%), and mixed type with thickened gallbladder-wall and fungating mass in 3 cases(13%). 3. Gallbladder carcinoma was associated with gallstones in 50%, with dilated bile ducts in 54%, with direct invasion of adjacent liver parenchyma in 50%, and with distant metastasis to the liver in 13%

  14. BASAL CELL CARCINOMA WITH ECCRINE DIFFERENTIATION: A RARE ENTITY

    Directory of Open Access Journals (Sweden)

    Divvya

    2014-05-01

    Full Text Available Basal cell carcinoma preferentially occurs in the face where the surgical excision with adequate margin is curative. Sometimes basal cell carcinoma is also reported rarely in other sites especially associated with basal cell carcinoma syndrome. The histological variants are Nodular basal cell carcinoma, Keratotic basal cell carcinoma, Adenoid basal cell carcinoma, Basal cell carcinoma with sebaceous differentiation. Of these variants, Basal cell carcinoma with eccrine differentiation is practically very rare.

  15. BASAL CELL CARCINOMA WITH ECCRINE DIFFERENTIATION: A RARE ENTITY

    OpenAIRE

    Divvya; Rehana; Viswanathan; Krishnaswamy; Anvar Ali

    2014-01-01

    Basal cell carcinoma preferentially occurs in the face where the surgical excision with adequate margin is curative. Sometimes basal cell carcinoma is also reported rarely in other sites especially associated with basal cell carcinoma syndrome. The histological variants are Nodular basal cell carcinoma, Keratotic basal cell carcinoma, Adenoid basal cell carcinoma, Basal cell carcinoma with sebaceous differentiation. Of these variants, Basal cell carcinoma with eccrine differen...

  16. del discurso

    Directory of Open Access Journals (Sweden)

    Alexander Mosquera

    2006-01-01

    Full Text Available En varios comunicados quedó reflejada la tensión de la reciente crisis entre Colombia y Venezuela, suscitada a raíz de la captura en diciembre de 2004 de un guerrillero de la FARC en Caracas (Rodrigo Granda. El presente trabajo es un avance de un proyecto de investigación, que persigue como objetivos: 1 describir el discurso implícito en dichos comunicados; 2 identificar los aspectos semánticos y pragmáticos presentes en la confrontación discursiva; y 3 delinear el componente ideológico reflejado en los comunicados. Para el respectivo análisis se siguieron algunos aspectos teóricos y metodológicos de Colle (2000, Bolívar (1998 yMolero de Cabeza (1985. Entre las conclusiones preliminares de este avance se tiene que, con el caso Granda, Colombia recurrió a la vieja política del "fin justifica los medios", a la vez que puso en entredicho el papel de Venezuela en la lucha contra el terrorismo, quizás como respuesta a su política exterior de estrechos vínculos con el gobierno estadounidense

  17. Diagnóstico por fluorescencia en el carcinoma basocelular previo a la cirugía micrográfica de Mohs

    OpenAIRE

    Beà Ardébol, Sònia

    2011-01-01

    El objetivo de este estudio es evaluar la utilidad del diagnóstico por fluorescencia del carcinoma basocelular previo a la cirugía micrográfica de Mohs. Por ellos hemos comparado el área que delimita la fluorescencia con el defecto quirúrgico final obtenido tras finalizar la cirugía. Se han seleccionado 22 pacientes con carcinoma basocelulares candidatos a ser tratados mediante cirugía de Mohs, debido a su histología y/o localización anatómica. El diagnóstico por fluorescencia se realizó el d...

  18. Inflammatory Breast Carcinoma Presenting with Two Different Patterns of Cutaneous Metastases: Carcinoma Telangiectaticum and Carcinoma Erysipeloides

    OpenAIRE

    Yaghoobi, Reza; Talaizade, Abdolhasan; Lal, Karan; Ranjbari, Nastaran; Sohrabiaan, Nasibe; Feily, Amir

    2015-01-01

    Cutaneous metastases can have many different clinical presentations. They are seen in patients with advanced malignant disease; however, they can be the initial manifestation of undetected malignancies. Inflammatory breast carcinoma is a rare and aggressive form of breast cancer that has a nonspecific appearance mimicking many benign conditions including mastitis, breast abscesses, and/or dermatitis. The authors report the case of a 40-year-old woman with inflammatory breast carcinoma present...

  19. Duplicidad tiroidea y carcinoma papilar en un tiroides ectópico. Presentación de caso

    Directory of Open Access Journals (Sweden)

    José Alberto Puerto Lorenzo

    2012-05-01

    Full Text Available Se presenta una paciente con tumor palpable ubicado en línea media de la región anterior del cuello, encima del hueso hioides, diagnosticado inicialmente como quiste del conducto tirogloso. Se realizó estudio preliminar, tanto clínico, como radiológico y citológico de la lesión. Mediante cirugía por técnica convencional, se extrajo el tumor. La biopsia por parafina definió la existencia de tiroides con carcinoma papilar. Añadido a dicha condición, la paciente presentaba glándula tiroidea en ubicación normal. Se considera un caso curioso, donde se mezclan los conceptos de duplicidad tiroidea y tiroides ectópico, con la presencia en este último de un carcinoma papilar.

  20. Carcinomas of the nasal cavity

    International Nuclear Information System (INIS)

    Between 1969-1985, 45 patients with carcinomas of the nasal cavity proper received curative treatment. Of these, 30 had squamous cell carcinoma, 1 un-differentiated carcinoma, 9 adenocarcinoma and 5 adenoid cystic carcinoma. 18 Patients were treated with definitive radiotherapy (interstitial brachy-therapy in 5 patients and external beam therapy in 13 patients), 27 received surgery and radiotherapy. Median length of follow-up was 11 years (range 2.8-16.8 years). 36 Patients had no evidence of disease at the last follow-up visit. All 14 patients with carcinoma of nasal septum had the disease controlled. 9/31 Patients with lesions of lateral wall and floor died of the disease, 5 of uncontrolled local disease, 2 of distant metastases, 2 of both. Disease specific survival rates at 5 and 10 years were 83 and 80%, the corresponding overall survival rates were 75 and 60%. Blindness occurred in 4 patients, 2 due to orbital exenteration and 2 to radiation injury to the cornea and optic pathway. Other infrequent side effects were bone necrosis, dental decay, nasal stenosis and septal perforation. This study indicated that prognosis of patients with nasal cavity carcinoma was better than that of patients with maxillary sinus cancer treated during the same era. In addition, the study showed that carcinoma of the nasal septum were smaller than those of lateral wall and floor at diagnosis, so that excellent control could be achieved by definitive radiotherapy; when accessible, interstitial brachytherapy might be the treatment of choice in such patients. (author). 18 refs.; 4 figs.; 2 tabs

  1. Tecnolog??as del cuidado del mundo

    OpenAIRE

    Higuera Esp??n, Javier de la

    2011-01-01

    Desde la ??ptica de la ontolog??a de la actualidad, este texto pretende pensar en la posibilidad de unas ???tecnolog??as del mundo??? que, en correlaci??n con las ???tecnolog??as del yo???, sean responsables del cuidado del acontecer singular que define nuestro presente, amenazado por fuertes tendencias homogeneizadoras capaces de cerrar o compactar el mundo. Por el contrario, el mundo s??lo es mundo si ???en ??l puede abrirse un afuera??? (J.-L. Nancy). Para ello analiza la naturaleza de es...

  2. El Banco del Sur

    OpenAIRE

    Espejo, Silvana

    2012-01-01

    En este trabajo abordaremos las características principales del Banco del Sur como una institución financiera sudamericana. Primero presentaremos sus principales características y explicaremos las características de un banco de desarrollo regional. Luego, expondremos el proceso de conformación del mismo haciendo un recorrido por sus principales antecedentes. Por último, cerraremos con una evaluación sobre el estado actual del Banco del Sur. (Párrafo extraído del texto a modo de resumen)...

  3. Hepatocellular carcinoma (Letter to the editor)

    DEFF Research Database (Denmark)

    Békássy, Albert N.; Garwicz, Stanislaw; Jensen, O.A.

    1994-01-01

    Øjenpatologi, Alagill's syndrome, hepatic carcinoma, biliary atresia, histopathology, liver, child, liver cirrhosis, autopsy, eyes, AFP......Øjenpatologi, Alagill's syndrome, hepatic carcinoma, biliary atresia, histopathology, liver, child, liver cirrhosis, autopsy, eyes, AFP...

  4. Duodenal Mucinous Carcinoma: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Jee, Keum Nahn [Dept. of Radiology, Dankook University Hospital, Dankook University College of Medicine, Cheonan (Korea, Republic of)

    2015-03-15

    Duodenal mucinous carcinoma is exceedingly rare and a case report about duodenal mucinous carcinoma in a 61-year-old man mimicking pancreatic cystic neoplasm by radiological evaluation, endoscopy, and even surgical findings is presented.

  5. The many faces of basal cell carcinoma

    OpenAIRE

    Jackson, Robert

    1982-01-01

    Basal cell carcinoma is the most easily cured carcinoma, but because of the many forms it can take, and because it grows so slowly, it can be misdiagnosed or neglected. The author discusses its more common forms and etiologic considerations.

  6. Basal cell carcinoma of penis: case report.

    OpenAIRE

    Sulaiman, M Z; Polacarz, S V; Partington, P E

    1988-01-01

    Basal cell carcinoma of the penis is rare. A patient who presented with a penile and scrotal ulcer due to basal cell carcinoma is reported. Wide local excision and split skin grafting were performed to excise the lesion completely.

  7. Las declaraciones publicitarias y la integración de las obligaciones que de ellas emanan al contenido del contrato con el consumidor

    Directory of Open Access Journals (Sweden)

    Juan Ignacio Granados Aristizabal

    2013-06-01

    Full Text Available El contrato con el consumidor contrastó con los paradigmas que sostuvieron el esquema del contrato común recogido en Código Civil y en el Código de Comercio colombiano, los cuales se basaron en el principio del individualismo. Este individualismo no resultó acorde a las nuevas dinámicas del mercado que, contrario a la igualdad que se predicó en los códigos decimonónicos, evidenciaron profundos desequilibrios que inobservados podrían en juego el ideal de la justicia contractual que se pretendía con el instrumento propio de la disposición de interese patrimoniales: el contrato. Por ello, el legislador se vio en la necesidad de hacer un nuevo tratamiento de las nuevas realidades del mercado, tratamiento que, desde la perspectiva del contrato con el consumidor, generó un importante número de remedios contractuales propios de este esquema contractual. En este desarrollo los principios medulares de la contratación privada y, especialmente, el de la buena fe, han cumplido un papel trascendental en la protección de los intereses del consumidor, la cual se logra mediante el desarrollo y la aplicación de sus reglas, que se hacen presentes proveyendo tales remedios contractuales, mediante la función integradora del contenido del contrato, en pro del logro de una real y no meramente formal justicia contractual. En el nuevo estatuto del Consumidor se hace expresa la regla de la integración del contrato, específicamente, en cuanto a lo que tiene que ver con la vinculación al contrato de las prestaciones contractuales que se pueden generar alrededor de la publicidad en el mercado, dado que la mismas influyen en la formación del consentimiento y en la integración del contenido del contrato. Este es precisamente el análisis que se pretende realizar en este escrito desde una perspectiva sistemática que pretenda una compresión cabal del fenómeno, a más de entender sus verdaderos suportes dogmáticos. Dicho análisis partirá desde una

  8. Las declaraciones publicitarias y la integración de las obligaciones que de ellas emanan al contenido del contrato con el consumidor

    Directory of Open Access Journals (Sweden)

    Juan Ignacio Granados Aristizabal

    2013-07-01

    Full Text Available El contrato con el consumidor contrastó con los paradigmas que sostuvieron el esquema del contrato común recogido en Código Civil y en el Código de Comercio colombiano, los cuales se basaron en el principio del individualismo. Este individualismo no resultó acorde a las nuevas dinámicas del mercado que, contrario a la igualdad que se predicó en los códigos decimonónicos, evidenciaron profundos desequilibrios que inobservados podrían en juego el ideal de la justicia contractual que se pretendía con el instrumento propio de la disposición de interese patrimoniales: el contrato. Por ello, el legislador se vio en la necesidad de hacer un nuevo tratamiento de las nuevas realidades del mercado, tratamiento que, desde la perspectiva del contrato con el consumidor, generó un importante número de remedios contractuales propios de este esquema contractual. En este desarrollo los principios medulares de la contratación privada y, especialmente, el de la buena fe, han cumplido un papel trascendental en la protección de los intereses del consumidor, la cual se logra mediante el desarrollo y la aplicación de sus reglas, que se hacen presentes proveyendo tales remedios contractuales, mediante la función integradora del contenido del contrato, en pro del logro de una real y no meramente formal justicia contractual. En el nuevo estatuto del Consumidor se hace expresa la regla de la integración del contrato, específicamente, en cuanto a lo que tiene que ver con la vinculación al contrato de las prestaciones contractuales que se pueden generar alrededor de la publicidad en el mercado, dado que la mismas influyen en la formación del consentimiento y en la integración del contenido del contrato. Este es precisamente el análisis que se pretende realizar en este escrito desde una perspectiva sistemática que pretenda una compresión cabal del fenómeno, a más de entender sus verdaderos suportes dogmáticos. Dicho análisis partirá desde una

  9. Endometrial carcinoma stage I.

    Science.gov (United States)

    Baram, A; Ron, I; Kupferminc, M; Inbar, M

    1997-01-01

    Standard staging and therapeutic approach to endometrial cancer involves lymph node sampling (LNS) at the time of total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy (BSO). Lymphadenectomy prolongs time of surgery and increases the risk of morbidity; where other predictors are available, it may not contribute important supplementary information. 185/247 women with stage I endometrial carcinoma underwent the standard surgery while 62 underwent TAH+BSO. Recurrence and survival were monitored for a mean of 6.5 years and retrospectively reviewed: the rates for groups with and without known lymph node status were alike [13.5% (25/185) recurrence for the former and 12.9% (8/62) for the latter, and 5-year survival rates of 75.7% (140/185) for the former and 74.2 (46/62) for the latter]. Myometrial invasion and histological grade appeared to have been highly accurate predictors without lymph node information. Because information on histological grade is available early and is highly predictive, its use could be incorporated into a revised management algorithm for stage I endometrial cancer which would depend upon ensuring lymphadenectomy for women with low grade histopathology and omitting it for those with high grades on the grounds that no further information is necessary to act appropriately. PMID:21590195

  10. Immunology of hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Hepatocellular carcinoma (HCC) is primarily a malignancyof the liver, advancing from a damaged, cirrhoticliver to HCC. Globally, HCC is the sixth most prevalentcancer and the third-most prevalent reason for neoplasticdisease-related deaths. A diverse array ofinfiltrating immunocytes regulates the developmentand progression of HCC, as is the case in many othercancers. An understanding of the various immunecomponents during HCC becomes necessary so thatnovel therapeutic strategies can be designed to combatthe disease. A dysregulated immune system (includingchanges in the number and/or function of immunecells, cytokine levels, and the expression of inhibitoryreceptors or their ligands) plays a key role in thedevelopment of HCC. Alterations in either the innateor adaptive arm of the immune system and cross-talkbetween them make the immune system tolerant totumors, leading to disease progression. In this review,we have discussed the status and roles of variousimmune effector cells (e.g. , dendritic cells, natural killercells, macrophages, and T cells), their cytokine profile,and the chemokine-receptor axis in promoting orimpeding HCC.

  11. Eyelid Carcinoma in Patients with Systemic Lymphoma

    OpenAIRE

    Debraj Shome; Diana Bell; Bita Esmaeli

    2010-01-01

    Purpose: To describe a series of patients with Non-Hodgkin′s lymphoma (NHL) and concomitant eyelid carcinoma. Methods: In this non-comparative interventional case series, we retrospectively reviewed the medical records of 5 patients with NHL who developed eyelid carcinoma. Results: The patients included one female and four male subjects. Systemic lymphoma had been diagnosed 1 to 72 months prior to development of the eyelid carcinoma. The lesions were basal cell carcinoma in three, and...

  12. Vulvar Merkel Carcinoma: A Case Report

    OpenAIRE

    2011-01-01

    This is a new case of Merkel cell carcinoma of the vulva. It is a rare neuroendocrine carcinoma with an aggressive behavior. Because of its rarity in this location, it is not clear whether it behaves differently from the usual neuroendocrine carcinomas of the skin. A case of a 63-year-old patient with vulvar Merkel carcinoma is presented. The clinical presentation, microscopic and immunohistochemical features, and treatment are discussed.

  13. Spontaneous regression of metastatic Merkel cell carcinoma.

    LENUS (Irish Health Repository)

    Hassan, S J

    2010-01-01

    Merkel cell carcinoma is a rare aggressive neuroendocrine carcinoma of the skin predominantly affecting elderly Caucasians. It has a high rate of local recurrence and regional lymph node metastases. It is associated with a poor prognosis. Complete spontaneous regression of Merkel cell carcinoma has been reported but is a poorly understood phenomenon. Here we present a case of complete spontaneous regression of metastatic Merkel cell carcinoma demonstrating a markedly different pattern of events from those previously published.

  14. Duplicidad tiroidea y carcinoma papilar en un tiroides ectópico. Presentación de caso Thyroid Duplication and Papillary Carcinoma in an Ectopic Thyroid. A Case Presentation

    Directory of Open Access Journals (Sweden)

    José Alberto Puerto Lorenzo

    2012-07-01

    Full Text Available

    Se presenta una paciente con tumor palpable ubicado en línea media de la región anterior del cuello, encima del hueso hioides, diagnosticado inicialmente como quiste del conducto tirogloso. Se realizó estudio preliminar, tanto clínico, como radiológico y citológico de la lesión. Mediante cirugía por técnica convencional, se extrajo el tumor. La biopsia por parafina definió la existencia de tiroides con carcinoma papilar. Añadido a dicha condición, la paciente presentaba glándula tiroidea en ubicación normal. Se considera un caso curioso, donde se mezclan los conceptos de duplicidad tiroidea y tiroides ectópico, con la presencia en este último de un carcinoma papilar.

    We present the case of a patient with a palpable tumor located in midline of the anterior neck above the hyoid bone, initially diagnosed as a thyroglossal duct cyst. Preliminary study of the lesion was conducted, both clinically and radiologically and cytologically. The tumor was removed through surgery by conventional technique. The paraffin biopsy defined the existence of thyroid papillary carcinoma. Despite this condition, the patient had thyroid gland in normal location. It is considered to be a curious case, combining the concepts of thyroid duplication and ectopic thyroid, with the presence, in this last one, of papillary carcinoma.

  15. Radiotherapy of bile duct carcinoma

    International Nuclear Information System (INIS)

    Twenty-six patients with cholangiocarcinoma and nineteen patients with carcinoma of the gallbladder treated with external radiotherapy were analyzed. Of the twenty-six patients, eighteen had cancer of the hepatic hilus (Klatskin), four intrahepatic and the remaining four extrahepatic cholangiocarcinoma. All but two of the patients had advanced disease. Thirty-three patients received primary irradiation for unresectable tumors, ten patients adjuvant irradiation after non-curative gross tumor resection, and two patients preoperative radiotherapy. Patients with cholangiocarcinoma who underwent radiotherapy with relatively small radiation field tolerated the treatment well, but there was no significant difference in survival according to field size or radiation doses (TDF). On the other hand, patients with carcinoma of gallbladder were treated with larger field size and lower dose. In the patients without gross tumor resection, those receiving radiation doses≥90 TDF had significantly longer survival than 2) had longer survival (p=0.07). The patients with gross tumor resection had significantly longer survival than that without resection in both cholangiocarcinoma and carcinoma of gallbladder. Postmortem examination revealed tumor recurrence even in the patients with gross tumor resection, but widespread distant metastases were present simultaneously. Cholangitis and liver abscess were special and lethal conditions related to these carcinomas, and intensive therapy must be developed for these conditions. External radiotherapy may be effective in the treatment of bile duct carcinoma in terms of palliation and survival. (author)

  16. CT diagnosis of thyroid carcinoma

    International Nuclear Information System (INIS)

    Purpose: To study the CT appearances of thyroid carcinoma and its cervical metastatic lymphadenopathy, as well as to evaluate the diagnostic criteria of tumor invasion of adjacent structures. Methods: CT findings of surgery and pathology proved thyroid carcinoma in 52 patients were analyzed. Results: All of the primary tumor were heterogeneous in density, 32 tumors (82.5%) were ill-defined. Fine granular calcifications were revealed in 11 primary tumors and metastatic lymph nodes in 5 cases. Cystic formation with intracystic high density papillary-like nodules were found in 4 primary tumors and metastatic lymphadenopathy in 5 cases. Trachea, esophagus and carotic artery invasion were proved by surgery in 22, 21 and 10 cases respectively. Serrated inner wall and tumor nodule protrusion into tracheal lumen were the definite signs of trachea invasion. Use tumor encasement over 1/2 of the circumference of esophagus and 1/3 of the circumference of carotid artery as the diagnostic criterion of invasion, sensitivity was 71.4%, 100.0% specificity was 96.3%, 95.2% respectively. Conclusion: Fine granular calcification and cystic formation with high attenuation intracystic papillary-like nodules were characteristic manifestations of primary thyroid carcinoma (especially papillary carcinoma) and its metastatic lymphadenopathy as well. Contrast enhanced CT scan is helpful in the diagnosis of thyroid carcinoma and the delineation of tumor extent, which is very important in surgical planning

  17. GENETIC INSTABILITY IN CERVICAL CARCINOMA

    Institute of Scientific and Technical Information of China (English)

    赵旻; 伍欣星; 邱小萍; 李晖; 戴天力; 谭云

    2002-01-01

    Objective: The role of human papillomavirus (HPV) in the development of cervical carcinoma has been clearly established but other factors could be involved in cervical tumorigenesis such as loss of heterozygosity (LOH) and microsatellite instability (MI). The aim of the present study was to investigate the genetic instability in cervical carcinoma tissues and provide evidence for discoveringnew tumor suppressor genes and screening diagnostic molecular marker of cervical carcinoma. Methods: Fifty primary cervical carcinoma samples from high-incidence area were analyzed by PCR for HPV16 infection, LOH and microsatellite instability. Results: HPV16 was detected in 88% of the cases. Sixty-six percent of total cases showed LOH with no more than 3 different loci per case. The highest frequency of the allelic loss was found in D18S474 (18q21, 40.5%). MI was detected in 4 cases (8%) only. Conclusion: Different percentages of LOH on specific chromosomal regions were found and MI was very infrequent in cervical carcinoma. The putative suppressor gene(s) could be located on specific chromosome regions such as 18q, and genetic instability could be involved in cervical tumorigenesis.

  18. Small cell undifferentiated carcinoma in the epididymis

    Institute of Scientific and Technical Information of China (English)

    CHEN Jia-wei; YUAN Lin; Hu Hong-hui

    2005-01-01

    @@ Small cell undifferentiated carcinoma is a special type of tumor which is usually found in the lungs. However, it is very rare in extra pulmonary tissues, especially in epididymis. One case of small cell undifferentiated carcinoma in the right epididymis, with partial differentiation to adenocarcinoma and neuroendocrine carcinoma is reported as follows.

  19. Basal cell carcinoma-treatment with cryosurgery

    Directory of Open Access Journals (Sweden)

    Kaur S

    2003-03-01

    Full Text Available Basal cell carcinoma is a common cutaneous malignancy, frequently occurring over the face in elderly individuals. Various therapeutic modalities are available to treat these tumors. We describe three patients with basal cell carcinoma successfully treated with cryosurgery and discuss the indications and the use of this treatment modality for basal cell carcinomas.

  20. Basal cell carcinoma-treatment with cryosurgery

    OpenAIRE

    Kaur S; Thami G; Kanwar A

    2003-01-01

    Basal cell carcinoma is a common cutaneous malignancy, frequently occurring over the face in elderly individuals. Various therapeutic modalities are available to treat these tumors. We describe three patients with basal cell carcinoma successfully treated with cryosurgery and discuss the indications and the use of this treatment modality for basal cell carcinomas.

  1. A ação do decanoato de nandrolona (Deca-durabolin® sobre parâmetros hematológicos e proteína total plasmática de ratos (Rattus rattus com depressão medular induzida após administração de sulfato de vincristina (Oncovin® Nandrolone decanoate (Deca-durabolin® effect on hematologic parameters and total plasma protein of rats (Rattus rattus with depressed bone marrow induced by vincristine (Oncovin®

    Directory of Open Access Journals (Sweden)

    Regina Raquel Perez

    2005-06-01

    Full Text Available É comum o clínico veterinário submeter animais à quimioterapia para controle de neoplasias e observar depressão medular, com presença de anemia, leucopenia e trombocitopenia como efeitos colaterais. Nesses casos, podem-se adotar duas condutas: supressão da quimioterapia e/ou utilização de estimulantes de medula óssea. Dentre os medicamentos estimulantes mais utilizados, podemos citar o decanoato de nandrolona (Deca-durabolin®, cuja eficácia para os animais domésticos é pouco estudada, com poucos relatos na literatura nacional e internacional. Este trabalho visou estudar a ação do decanoato de nandrolona (DN, na dose de 1,5mg/kg, por via intramuscular, como estimulante de medula óssea em ratos (Rattus rattus com supressão medular induzida pelo sulfato de vincristina (Oncovin® nas doses de 4 e 8mg/m², por via intraperitoneal. Foram realizados hemograma, contagem de plaquetas e determinação da proteína total plasmática. Os resultados obtidos mostram que sua eficácia na estimulação da medula óssea depende do grau de depressão medular e da dose administrada.In veterinary practice it is common to submit animals to chemotherapy for neoplasia control and to observe bone marrow depression, with presence of anemia, leukopenia and thrombocytopenia as collateral effects. In these cases, two therapeutical protocols can be adopted: chemotherapy by suppression and/or use of bone marrow stimulants. Nandrolone decanoate (Deca-durabolin® is a bone marrow stimulant used in veterinary medicine despite few studies were conducted in domestic animals. The objective of this study was to analyse nandrolone decanoate (ND-1,5mg/kg, intramuscular, as a bone marrow stimulant in rats (Rattus rattus with medular suppression induced by 4 and 8 mg/m² (intraperitoneal of vincristine (Oncovin®. Hemogram, platelets counting and total plasma protein determination were evaluated. These results showed that its effectiveness in bone marrow stimulation

  2. Accesibilidad del sitio web del CONAPRED

    OpenAIRE

    Luján Mora, Sergio

    2012-01-01

    Accesibilidad del sitio web del CONAPRED (Consejo Nacional para Prevenir la Discriminación) de México. Más información: - http://accesibilidadweb.dlsi.ua.es - http://desarrolloweb.dlsi.ua.es Autor: Sergio Luján Mora, profesor de la Universidad de Alicante (http://www.ua.es).

  3. Radioimmune localization of occult carcinoma

    International Nuclear Information System (INIS)

    Patients with a rising serum carcinoembryonic antigen level and no clinical or roentgenographic evidence of recurrent or metastatic cancer present a treatment dilemma. Eleven such patients, 10 with a previously treated colorectal carcinoma and 1 with a previously treated breast carcinoma, received an injection of the anticarcinoembryonic antigen monoclonal antibody ZCE-025 labeled with the radioisotope indium 111. Nuclear scintigraphy was performed on days 3 and 5 through 7 to detect potential sites of tumor recurrence. The monoclonal antibody scan accurately predicted the presence or absence of occult malignancy in 7 (64%) patients. Second-look laparotomy confirmed the monoclonal antibody scan results in the patients with colorectal cancer, and magnetic resonance imaging confirmed metastatic breast cancer. This study demonstrates that In-ZCE-025 can localize occult carcinoma and may assist the surgeon in facilitating the operative exploration. In-ZCE-025 assisted in the initiation of adjuvant therapy for the patient with breast cancer

  4. Medullary carcinoma of the colon

    DEFF Research Database (Denmark)

    Fiehn, Anne-Marie Kanstrup; Grauslund, Morten; Glenthøj, Anders;

    2015-01-01

    Medullary carcinoma of the colon is a rare variant of colorectal cancer claimed to have a more favorable prognosis than conventional adenocarcinomas. The histopathologic appearance may be difficult to distinguish from poorly differentiated adenocarcinoma. The study aimed to evaluate the diagnostic...... interobserver agreement and to characterize the immunohistochemical and molecular differences between these two subgroups. Fifteen cases initially classified as medullary carcinoma and 30 cases of poorly differentiated adenocarcinomas were included. Two pathologists reviewed the slides independently without...... differences in CK20 (p = 0.005) expression and in the rate of BRAF mutations (p = 0.0035). In conclusion, medullary carcinomas of the colon are difficult to discriminate from poorly differentiated adenocarcinoma even with the help of immunohistochemical and molecular analyses. This raises the question whether...

  5. Carcinoma of Maxillary Sinus. A case Presentation. Carcinoma de seno maxilar. Presentación de caso.

    Directory of Open Access Journals (Sweden)

    Ángel Luis Cruz Leiva

    2007-01-01

    Full Text Available

    Tumors of the nasosinuous tract developed in the air cavities usually present a considerable growing before the patient feel any symptom or sign. Great part of the symptomatology is given due to the invasion of the tumor to neighbour structures such as oral and nasal cavities and orbits. A case of a 62 year-old male patient is presented after being under a dental extraction. A bucco-sinuous communication was diagnosed. It did not respond to different treatments and after some moths an epidermoid carcinoma of the right maxillary sinus appeared. It is of great interest to let this case been known in order to outstand the importance of an early diagnosis to get a better vital prognosis in this kinds of lesions.

    Los tumores del tracto nasosinusal al desarrollarse en cavidades aéreas, suelen presentar un considerable crecimiento antes de dar lugar a signos y síntomas. Gran parte de la sintomatología se debe a la invasión del tumor a estructuras vecinas, como son la órbita y la cavidad nasal y oral. Se presenta el caso de un paciente masculino, de 62 años de edad, al cual, tras haber sido sometido a una extracción dentaria, se le diagnosticó una comunicación bucosinusal, que no cedió a varias formas de tratamiento, lo que resultó varios meses después en un carcinoma epidermoide del seno maxilar derecho. El interés de dar a conocer este caso, radica en destacar la importancia de un diagnóstico precoz para conseguir mejorar el pronóstico vital en este tipo de afecciones.

  6. Carcinoma fusocelular de cavidad oral: Revisión de 9 casos Spindle cell carcinoma of the oral cavity: A review of 9 cases

    Directory of Open Access Journals (Sweden)

    G. Gómez Oliveira

    2006-02-01

    Full Text Available El carcinoma fusocelular es una variedad maligna y poco frecuente del carcinoma de células escamosas. Es una tumoración constituida por una doble proliferación celular: una sarcomatosa de células fusocelulares y otra carcinomatosa de células epiteliales. Aunque puede afectar a cualquier parte del organismo, es más frecuente encontrarla en vías aerodigestivas superiores. Afecta con mayor frecuencia a varones entre la 6ª y 7ª décadas de la vida. Tiene un comportamiento agresivo con tendencia a la recurrencia. El alcohol y tabaco han sido identificados como los factores de riesgo más importantes. Su diagnóstico histológico es complicado y muchas veces es necesario recurrir a técnicas de inmunohistoquímica y al uso del microscopio electrónico. En la actualidad, se le atribuye un origen epitelial. El objetivo de este trabajo es presentar una revisión de 9 casos de carcinoma fusocelular localizados en cavidad oral recogidos en nuestro servicio entre los años 1985 a 2004, describiendo su comportamiento clínico y tratando de comprender la patogenia de esta controvertida estirpe tumoral.Spindle cell carcinoma is a malignant and rare variant of squamous cell carcinoma. The histological pattern is composed of a double cell proliferation: a sarcomatous component made up of spindle-shaped cells and a carcinomatous component made up of epithelial cells. Nearly all the anatomy of the body can be affected by these tumors although the most common location is the upper aerodigestive tract. With regard to sex distribution, it is more frequent in males than in females in their sixth and seventh decades of life. Its behavior is aggressive and it tends to recur after treatment. The most important risk factors are alcohol and tobacco. The histological diagnosis is complicated, so immunohistochemical techniques and the use of electron microscopy are usually necessary. Nowadays, its epithelial origin is accepted. The aim of this article is to report a

  7. Geologia del Baix Ter

    OpenAIRE

    Mas-Pla, Josep

    1986-01-01

    Article que analitza el valor i la singularitat de les zones humides del Baix Ter, tenint en compte la descripció de les característiques geològiques de la Plana del Ter i dels diferents ambients morfodinàmics que s' hi troben

  8. Il dono del racconto

    DEFF Research Database (Denmark)

    Polito, Paola

    1998-01-01

    L'articolo indaga a vari livelli strutturali del romanzo "Il coraggio del pettirosso" (rete metaforica, dialogismo diegetico, dialogismo come fenomeno di voce, strategie discorsive messe in atto dalla voce narrante, stile colloquiale) la complessa realizzazione testuale del genere narrativo /racc...

  9. Carcinoma of the ovary

    International Nuclear Information System (INIS)

    Ovarian carcinoma presents a difficult management problem. Localized disease is difficult to diagnose and advanced disease is usually present by the time the patient presents with symptoms (pain, discomfort, distention, mass, and so on). Surgery alone is inadequate because even if a complete resection is performed approximately 50% of cases recur. Postoperative adjuvant therapy is given in the form of radiation therapy, radioisotopes, or chemotherapy for stage I, stage II, and optimal stage III disease. No clear benefit can be ascribed to any treatment. It is evident, however, that abdominopelvic irradiation is superior to pelvic irradiation alone; many of patients receiving pelvic irradiation alone fail in the upper abdomen owing to occult disease. Prognosis depends on many variables in addition to stage: grade of tumor, histology, age of patient,and completeness of surgery. Several studies have tried to incorporate these variables into their results. Dembo perhaps has been the most diligent in incorporating them into appropriate low-, intermediate- and high-risk groups. Patients with residual macroscopic or bulk disease have the poorest prognosis; chemotherapy is the usual first-line treatment choice, although no optimal treatment is known. Regimens usually include cisplatin; many single agent and multiagent drugs have been tried. The challenge of the future lies in earlier diagnosis; those diagnosed early can attain long term survival. The problem lies in choosing the appropriate therapy because randomized controlled studies are few and all modalities can be effective. No clear picture emerges about the best treatment, although there is a slight indication that irradiation affords better intra-abdominal control. Continued studies are needed to prove this

  10. Radiation therapy in bronchogenic carcinoma

    International Nuclear Information System (INIS)

    Response of intrathoracic symptoms to thoracic irradiation was evaluated in 330 patients. Superior vena caval syndrome and hemoptysis showed the best response, with rates of 86% and 83%, respectively, compared to 73% for pain in the shoulder and arm and 60% for dyspnea and chest pain. Atelectasis showed re-expansion in only 23% of cases, but this figure increased to 57% for patients with oat-cell carcinoma. Vocal cord paralysis improved in only 6% of cases. Radiation therapy has a definite positive role in providing symptomatic relief for patients with carcinoma of the lung

  11. Radiotherapy and verrucosus carcinoma of the larynx

    International Nuclear Information System (INIS)

    Squamous cell carcinoma is the most common upper aerodigestive tract (UAT) carcinoma (>90%). Precising the prevalence of the so-called varieties of squamous cell carcinoma has proved difficult. Differential diagnosis is necessary, on account of the differences between varieties both in management and prognosis. One of such varieties, verrucosus carcinoma of the larynx, is a well-defined, no-metastatic tumor, characterized as a slow-growth neoplasm, of verrucosus exophyitic pattern. Since laryngeal verrucosus cancer may transform into anaplastic carcinoma, the role of radiotherapy in its treatment has been discussed. The aim of the present literature review was to shed light on this controversy

  12. Epstein-Barr virus and gastric carcinoma

    OpenAIRE

    Takada, K

    2000-01-01

    The Epstein-Barr virus (EBV) is detected in the tissue of about 10% of gastric carcinoma cases throughout the world. In each case, 100% of carcinoma cells are infected with EBV. Analysis of EBV in carcinoma biopsies indicates that carcinoma is formed by the proliferation of a single EBV infected cell. These findings suggest that EBV plays an important role in the development of EBV positive gastric carcinomas. The EBV genes expressed are EBV determined nuclear antigen 1 (EBNA1), two small non...

  13. Thyroid Metastasis from Breast Carcinoma Accompanied by Papillary Thyroid Carcinoma

    Directory of Open Access Journals (Sweden)

    Song-I Yang

    2014-07-01

    Full Text Available Metastasis to the thyroid gland is very rare. Recently, we experienced a case of thyroid metastasis from breast cancer accompanying a papillary thyroid. A 51-year-old female patient presented with a palpated lymph node on her left lateral neck. The patient had undergone a left modified radical mastectomy followed by chemotherapy and hormonal therapy 12 years prior. Ultrasonography of the neck revealed a malignant looking nodule at the left thyroid lobe, measuring 0.9 × 0.9 cm, and several cystic nodules at the right thyroid lobe. Ultrasonography of the neck additionally revealed a malignant looking lymph node at the right level VI. Fine-needle aspiration of the left thyroid lobe resulted in a diagnosis of papillary thyroid carcinoma and that of the right level VI in Hurthle cell lesion. The patient had a total thyroidectomy with selective dissection of the left neck node. Pathologic assessment of the specimen revealed metastatic carcinoma from the breast carcinoma and papillary thyroid carcinoma. Although the thyroid gland is highly vascularized, metastasis of malignant tumors to the thyroid is relatively rare and detection of metastasis shows a low frequency. So a careful evaluation of thyroid tumor should be considered in a patient with a history of other malignancy.

  14. Carcinoma mucoepidermoide central de la mandíbula, en un paciente con displasia fibrosa quística mandibular

    Directory of Open Access Journals (Sweden)

    Ángel Lazo- Valladares

    2006-10-01

    Full Text Available El carcinoma mucoepidermoide de glándula salival es un tumor frecuente; constituye el 15% de los tumores de dicha estructura. Sin embargo, en la mandíbula son mucho menos frecuentes (menos de 200 casos reportados y se le conoce como carcinoma mucoepidermoide central. La patogenia de este tumor intraóseo sigue siendo controversial. Al igual que otros carcinomas intaóseos primarios, puede tener varios orígenes: 1 atropamiento de glándulas mucosas retromolares en la mandíbula, 2 epitelio del seno maxilar, 3 atropamiento iatrogénico de glándula salival menor (ej. en una osteomielitis o sinusitis crónica, 4 remanentes de lámina dental, 5 remanentes de tejido de glándula salival en la mandíbula, 6 transformación neoplásica de células mucosecretoras en el epitelio de revestimiento de quistes odontogénicos. Se presenta el caso de un hombre con un carcinoma mucoepidermoide central de la mandíbula y se hace una revisión del tema.Mucoepidermoid carcinomas of the salivary glands are frequent lesions that account for 15% of all salivary gland tumors, they are very infrequent in the mandible, with less than 200 cases reported and known as central mucoepidermoide carcinoma. The pathogenesis of this intraosseous tumor is still controversial. Several theories of their pathogenesis have been postulated: 1 entrapment of retromolar mucous glands within the mandible, 2 maxilla sinusepithelium, 3 iatrogenic entrapment of minor salivary glands (chronic osteomielitis or sinusitis, 4 dental lamina remnants, 5 developmentally included embryonic remnants of submandibular glands within the mandible, 6 neoplastic transformation of mucus-secreting cells in the epithelial lining of odontogenic cysts. We present the case of man with a central mucoepidermoide carcinoma and review of the literature of this uncommon condition.

  15. MRI analysis of renal cell carcinoma

    International Nuclear Information System (INIS)

    Objective: To analyze MRI manifestation and enhancement of renal cell carcinoma, and to improve the diagnosis of renal cell carcinoma. Methods: 48 cases of renal cell carcinoma proven by surgery and pathology were reviewed. MRI scans including T1WI, T2WI, TRUFI and contrast enhancement were carried out in all cases and dynamic contrast-enhanced MRI was performed in 15. Results: Of the 48 cases, there were clear cell carcinoma in 41, chromophobe cell carcinoma in 4 and papillary cell carcinoma in 3. The tumors were homogeneously T1 iso- or hypointense in 33 and heterogeneous in 15; homogeneously T2 hyperintense in 14, isointense in 6 and heterogeneous in 28 patients. Pseudocapsule was found in 10 cases. Contrast enhancement was homogeneous in 6, heterogeneous in 34, irregularly peripheral within the wall in 5, and homogeneously circular in 3. Conclusion: MRI can accurately diagnose renal cell carcinoma and help to determine the cell subsets. (authors)

  16. Osteopontin expression in salivary gland carcinomas

    DEFF Research Database (Denmark)

    Bjørndal, Kristine; Larsen, Stine R; Godballe, Christian;

    2011-01-01

    J Oral Pathol Med (2010) Background:  In several cancer types, osteopontin (OPN) expression has been correlated with tumor progression and prognosis. Two earlier studies have examined OPN expression in salivary gland carcinomas with contradictory results. Methods:  One hundred and seventy......-five patients with a primary salivary gland carcinoma diagnosed from January 1, 1990 to December 31, 2005 were identified in the local pathology register, Odense University Hospital. Criteria as documented by Allred et al. were used to assess OPN immunostaining that was performed on surgical specimens. Results......:  Osteopontin was expressed in all salivary gland carcinomas. Adenoid cystic carcinomas had the highest mean sum score (7.3) and a significantly higher proportion of carcinomas with high OPN sum score than both mucoepidermoid carcinoma and acinic cell carcinoma. Correlation of OPN expression with known...

  17. DETECTION OF TELOMERASE ACTIVITY IN BREAST CARCINOMA

    Institute of Scientific and Technical Information of China (English)

    Yang Wentao; Xu Liangzhong; Zhang Taiming; Zhu weiping; Li Xiaomei; Jin Aiping

    1998-01-01

    Objective:To investigate the significance of telomerase activity in breast carcinoma with its respect to axillary lymph node status. Methods: Telomerase activity was analyzed in 88 breast carcinomas and 16benign breast lesions, using polymerase chain reaction (PCR)-based telomeric repeat amplification protocol (TRAP) assay. Results: Telomerase activity was detected in 75 (85%) of 88 breast carcinomas (including three breast carcinomas in situ which were all positive for telomerase activity), whereas in benign breast lesions analyzed only 2(12.5%) of 16 cases were positive for telomerase activity. The difference between the two groups was statistically significant (P<0.001). Besides,telomerase activity was expressed significantly higher in node-positive breast carcinoma (93%) than in nodenegative ones (77%) (P<0.05). Conclusion: Our results suggest that telomerase activation plays an important role during breast carcinoma development. It is possible that this enzyme may serve as an early indication of breast carcinoma.

  18. Isolated Uterine Metastasis of Invasive Ductal Carcinoma

    Directory of Open Access Journals (Sweden)

    Deniz Arslan

    2013-01-01

    Full Text Available Introduction. Most common metastasis sites of breast cancer are the lungs, bones, liver, and brain, whereas uterine involvement by metastatic breast disease is rare. Metastatic carcinoma of the uterus usually originates from other genital sites, most commonly being from the ovaries. Invasive lobular carcinoma spreads to gynecologic organs more frequently than invasive ductal carcinoma. Case Report. A 57-year-old postmenopausal woman was diagnosed with breast carcinoma 2 years ago and modified radical mastectomy was performed. Pathological examination of tumor revealed invasive ductal carcinoma, stage IIIc. She presented with abdominal pain and distension. Diagnostic workup and gynecologic examination revealed lesions that caused diffuse thickening of the uterus wall. Endometrial sampling was performed for confirmation of the diagnosis. She underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Breast carcinoma metastases in endometrium and myometrium were confirmed histopathologically and immunohistochemically. Conclusion. We herein report the first case of isolated uterine patient who had invasive ductal carcinoma of breast.

  19. Biodiversidad del margen continental del Caribe colombiano.

    OpenAIRE

    2010-01-01

    Incluye valiosa información producto de varios años de investigación marina de las aguas profundas, la plataforma continental y el talud superior del Caribe colombiano, llevada a cabo por un grupo multidisciplinario de investigadores en áreas de taxonomía, geología, ecología, cartografía y conservación del Invemar. Dentro de los resultados más destacados se encuentra el haber colectado e identificado más de 1600 especies, de las cuales alrededor del 35% se constituyeron en primeros registr...

  20. Radiotherapy T1 glottic carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Zablow, A.I.; Erba, P.S.; Sanfillippo, L.J.

    1989-11-01

    From 1970 to 1985, curative radiotherapy was administered to 63 patients with stage I carcinoma of the true vocal cords. Precision radiotherapeutic technique yields cure rates comparable to surgical results. Good voice quality was preserved in a high percentage of patients.

  1. Tumor Budding in Colorectal Carcinomas

    Directory of Open Access Journals (Sweden)

    Sevda SERT BEKTAŞ

    2012-01-01

    Full Text Available Objective: In colorectal carcinomas, tumor budding has been defined as the presence of isolated single tumor cells or small cell clusters in the stroma at the invasive tumor margin. In this study, the relationship between tumor budding density at the invasive tumor margin and pathological parameters is investigated.Material and Method: Haematoxylin and eosin stained slides of 73 cases with colorectal carcinoma were retrospectively evaluated for the presence and intensity of tumor budding by 2 observers. After the specimens were assessed, the highest density of tumor budding area was counted in a microscopic field of x200. Cases were separated into 2 groups according to tumor budding density as low grade (<10 and high grade (≥10. The relationship of these groups with depth of tumor invasion, histological grade, vascular invasion and lymph node involvement was investigated.Results: Of the 73 colorectal carcinoma cases, 33 (45.2% had low and 40 (54.8% had high grade tumor budding density, respectively. There was a statistically significant relationship between high grade tumor budding density and histological grade (p=0.042, lymph node involvement (p=0.0001 and vascular invasion (p=0.0034.Conclusion: High grade tumor budding density is associated with aggressive phenotypical features in colorectal carcinoma.

  2. Breast metastases from rectal carcinoma

    Institute of Scientific and Technical Information of China (English)

    LI Jia; FANG Yu; LI Ang; LI Fei

    2011-01-01

    Metastases to the breast from extramammary neoplasms are very rare, constituting 2.7% of all malignant breast tumours. The most common primary tumor metastatic to the breast is primary breast cancer. Rectal cancer metastasizing to the breast is extremely rare. We report a case of aggressive rectal carcinoma with metastasis to the breast.

  3. Cryotherapy in basal cell carcinoma

    OpenAIRE

    Sandra A; Balachandran C; Shenoi S; Sabitha L; Pai Satish; Ravikumar B; Roy Alfred

    1999-01-01

    Cryotherapy has proved to be an effective tool in the management of various dermatoses. We report 6 patients with histopathologically proven basal cell carcinoma of variable sizes treated with liquid nitrogen cryotherapy by the open spray technique. Lesions tended to heal with depigmentation and scar formation. However depigmented areas often repigmented over a period of time.

  4. Genomic profile of ovarian carcinomas

    OpenAIRE

    Micci, Francesca; Haugom, Lisbeth; Vera M. Abeler; Davidson, Ben; Tropé, Claes G; Heim, Sverre

    2014-01-01

    Background It is known that all tumors studied in sufficient number to draw conclusions show characteristic/specific chromosomal rearrangements, and the identification of these chromosomes and the genes rearranged behind the aberrations may ultimately lead to a tailor-made therapy for each cancer patient. Knowledge about the acquired genomic aberrations of ovarian carcinomas is still unsatisfactory. Methods ...

  5. Rendimiento diagnóstico de la tomografía de emisión de positrones por coincidencia (PET-c) en la estadificación del carcinoma pulmonar de célula no pequeña (CPCNP).

    OpenAIRE

    Reyes Ojeda, Mª Dolores

    2008-01-01

    RESUMEN Se analiza el rendimiento diagnóstico de la tomografía de emisión de positrones por coincidencia (PET-c) en la estadificación del cáncer de pulmón de célula no pequeña (CPCNP). El proyecto consta de dos partes realizadas de forma sucesiva: En primer lugar, se diseña y elabora una parte experimental mediante un fantoma para establecer la resolución espacial máxima del equipo utilizado (gammacámara de coincidencia de triple cabezal detector), teniendo en cuenta el efecto de la cor...

  6. Taponamiento cardíaco secundario a carcinoma papilar esclerosante difuso de tiroides Metastatic cardiac tamponade as initial manifestation of papillary thyroid carcinoma

    Directory of Open Access Journals (Sweden)

    Verónica Riva

    2011-12-01

    Full Text Available El carcinoma papilar, variante esclerosante difusa, corresponde al 2% de todos los carcinomas papilares de la tiroides. Se caracteriza por comprometer de manera difusa y bilateral a la glándula tiroides. Clínicamente se manifiesta con metástasis ganglionares y pulmonares, afectando predominantemente a mujeres jóvenes. Se describe un caso de taponamiento cardíaco como presentación inicial de un carcinoma papilar de tiroides variante esclerosante difusa. Una mujer de 32 años concurrió al servicio de emergencias médicas refiriendo epigastralgia y tos seca. Durante el examen físico se constató hipotensión arterial, taquicardia y ruidos cardíacos disminuidos. Se realizó un ecocardiograma, observándose derrame pericárdico. Por medio de una pericardiocentesis se obtuvo líquido pericárdico, cuyo análisis mostró células neoplásicas. Durante la evolución la paciente presentó recurrencia del derrame pericárdico por lo que se realizó una ventana pleuropericárdica, detectándose durante la cirugía una lesión nodular subpleural, la cual fue biopsiada e informada posteriormente como una metástasis de carcinoma papilar vinculable a origen tiroideo. Se realizó una tiroidectomía total con linfadenectomía cervical bilateral. El diagnóstico final fue carcinoma papilar, variante esclerosante difusa. Esta variante infiltra el tejido conectivo de los espacios interfoliculares, simulando una tiroiditis y se caracteriza por una permeación vascular temprana. En oposición a la variante clásica, la esclerosante difusa presenta mayor agresividad y mayor tasa de recurrencia. El carcinoma papilar de tiroides debe tenerse presente como diagnóstico diferencial en nuestro medio, en todas aquellas lesiones neoplásicas papilares metastásicas, más aún si se trata de mujeres jóvenes.Papillary carcinoma, diffuse sclerosing variant corresponds to 2% of all papillary thyroid carcinomas. It is usually diffuse and bilateral, affecting the entire

  7. Carcinoma escamoso gingival: caso clínico y diagnóstico diferencial

    OpenAIRE

    Chimenos Küstner, Eduardo; Finestres Zubeldia, Fernando; Huguet Redecilla, Pere

    2001-01-01

    Se presenta el caso clínico de una mujer de 59 años que consulta por presentar una lesión tumoral en la encía del segundo cuadrante, de unas 6 semanas de evolución. Se presentan los resultados del estudio histopatológico y se plantea el diagnóstico diferencial. Se comentan las entidades más probables del diagnóstico diferencial (granuloma piógeno, carcinoma escamoso y metástasis gingivales), discutiéndose asimismo la importancia de los aspectos radiológicos. Se concluye que el diagnóstico def...

  8. Metastatic renal cell carcinoma management

    Directory of Open Access Journals (Sweden)

    Flavio L. Heldwein

    2009-06-01

    Full Text Available PURPOSE: To assess the current treatment of metastatic renal cell carcinoma, focusing on medical treatment options. MATERIAL AND METHODS: The most important recent publications have been selected after a literature search employing PubMed using the search terms: advanced and metastatic renal cell carcinoma, anti-angiogenesis drugs and systemic therapy; also significant meeting abstracts were consulted. RESULTS: Progress in understanding the molecular basis of renal cell carcinoma, especially related to genetics and angiogenesis, has been achieved mainly through of the study of von Hippel-Lindau disease. A great variety of active agents have been developed and tested in metastatic renal cell carcinoma (mRCC patients. New specific molecular therapies in metastatic disease are discussed. Sunitinib, Sorafenib and Bevacizumab increase the progression-free survival when compared to therapy with cytokines. Temsirolimus increases overall survival in high-risk patients. Growth factors and regulatory enzymes, such as carbonic anhydrase IX may be targets for future therapies. CONCLUSIONS: A broader knowledge of clear cell carcinoma molecular biology has permitted the beginning of a new era in mRCC therapy. Benefits of these novel agents in terms of progression-free and overall survival have been observed in patients with mRCC, and, in many cases, have become the standard of care. Sunitinib is now considered the new reference first-line treatment for mRCC. Despite all the progress in recent years, complete responses are still very rare. Currently, many important issues regarding the use of these agents in the management of metastatic renal cancer still need to be properly addressed.

  9. Asociación sincrónica de carcinoma de paratiroides con tumor pardo mandibular y carcinoma papilar de tiroides

    OpenAIRE

    Jaime Alonso Reséndiz-Colosia; Sergio Arturo Rodríguez-Cuevas; Sinuhé Barroso-Bravo; José Francisco Gallegos-Hernández; Martín Hernández-San Juan; Fernando Gómez-Acosta

    2008-01-01

    Introducción: Los nódulos tiroideos en pacientes con hiperparatiroidismo primario son frecuentes, pero la asociación sincrónica de carcinoma de paratiroides y carcinoma papilar de tiroides es un evento poco común. Caso clínico: Paciente de 42 años de edad con tumor en región mandibular derecha y nódulo en la cara anterior de cuello que dependía del lóbulo derecho de tiroides. La biopsia por aspiración de la lesión en cavidad oral indicó lesión de células gigantes. Se identificó hipercalcemia ...

  10. Expression of ATP7B in human gastric cardiac carcinomas in comparison with distal gastric carcinomas

    Institute of Scientific and Technical Information of China (English)

    Da-Long Wu; Hui-Xing Yi; Feng-Ying Sui; Xiao-Hong Jiang; Xiao-Ming Jiang; Ying-Ying Zhao

    2006-01-01

    AIM: To analyze expression of ATP7B in gastric cardiac adenocarcinomas, its clinicopathologic significance, in comparison with distal gastric adenocarcinomas.METHODS: Immunohistochemical avidin-biotin peroxidase complex method was applied to detect the expression of ATP7B in 49 cases of cardiac carcinomas,the corresponding adjacent non-neoplastic epithelium and 55 cases of distal gastric carcinomas.RESULTS: The proportion of ATP7B positive samples in gastric cardiac carcinomas (51.0%, 25 of 49) was significantly higher than that in the corresponding adjacent non-neoplastic epithelium (22.4%, 11 of 49)(P = 0.003). ATP7B expression in poorly differentiated gastric cardiac carcinomas was significantly higher than that in well/moderately differentiated gastric cardiac carcinomas (P = 0.030). ATP7B expression in gastric cardiac carcinomas was independent of age, tumor size, nodal stage and metastasis status. ATP7B protein was detected in 30.9% (17/55 cases) of distal gastric carcinomas, markedly lower than that in gastric cardiac carcinomas (P = 0.037).CONCLUSION: ATP7B protein is frequently overexpressed in gastric cardiac carcinomas, and correlated with the differentiation of cardiac carcinoma. ATP7B expression in gastric cardiac carcinomas is significantly higher than that in distal gastric carcinomas, which might partially explain the difference of chemotherapy response and prognosis between these two gastric carcinomas.

  11. Cambios en el rol social del paciente oncohematológico: un estudio de caso Changes in the oncohematologic patient's social role: a case study

    Directory of Open Access Journals (Sweden)

    David Nondedeu Arráez

    2011-09-01

    Full Text Available El tratamiento habitual de las enfermedades oncohematológicas consta de tratamiento específico de quimioterapia, así como tratamiento de soporte para evitar o paliar los efectos secundarios. Dentro de este tratamiento de soporte se incluyen medidas preventivas derivadas de la inmunodepresión medular como la modificación de la alimentación y el aislamiento. En este estudio de caso describimos cómo afectan todas estas medidas terapéuticas y de soporte en el rol social de un paciente afectado de leucemia mieloide aguda. Los datos cualitativos procedentes del paciente fueron obtenidos mediante una entrevista semiestructurada, transcritos a papel y analizados y agrupados según las dimensiones familiar, laboral, social y emocional. Los resultados indican que existe una ruptura y un cambio en el rol social del paciente, así como un cambio en su estatus emocional.The usual treatment of oncohematological diseases consists of specific treatment chemotherapy and supportive care to prevent or mitigate the secondary effects. Within this supportive treatment includes pre-ventive measures resulting from bone marrow immunosuppression as dietary changes and isolation. In this case study we describe how these therapeutic and support measures affect in the social role of a patient suffering from acute myeloid leukemia. Qualitative data from the patient were obtained through a semistructured interview, transcribed to paper and analyzed and grouped according to family size, employment, social and emotional development. The results indicate a break and a change in the patient's social role and a change in emotional status.

  12. Carcinoma escamoso metastásico primario de origen desconocido. Presentación de un caso Primary Metastatic Squamous Cell Carcinoma of Unknown Origin. A Case Report

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Serra Valdés

    2012-12-01

    Full Text Available El cáncer primario oculto representa según varias series del 0,5 al 7 % de todos los cánceres que se diagnostican y la edad media de presentación es 60 años. Se presenta un caso de metástasis ganglionar de carcinoma primario de células escamosas no identificado, de una paciente de 58 años de edad, de color de piel blanca, con antecedentes de salud, ama de casa, que fumaba desde joven e ingería alcohol frecuentemente. Ingresó con aumento de volumen de los ganglios del cuello. Se diagnosticó por biopsia metástasis de carcinoma escamoso. No pudo identificarse el primario en vida ni en la necropsia. El cáncer metastásico primario de origen desconocido sigue siendo un reto para la práctica clínica.Occult primary cancer represents, according to several series, from 0,5 % to 7 % of all diagnosed cancers, the average onset age being 60 years old. We report the case of nodal metastasis of unidentified primary squamous cell carcinoma in a 58 years old patient with white skin and a history of good health. The patient was a housekeeper who smoked from early age and frequently consumed alcohol. She was admitted with an enlargement of the neck glands. Metastases of squamous cell carcinoma were diagnosed through biopsy. Primary cancer was not identified neither while still alive or at necropsy. Primary metastatic cancers of unknown origin remain a challenge for clinical practice.

  13. Epidemiologia do carcinoma basocelular Epidemiology of basal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Valquiria Pessoa Chinem

    2011-04-01

    Full Text Available O carcinoma basocelular é a neoplasia maligna mais comum em humanos e sua incidência vem aumentando nas últimas décadas. Sua grande frequência gera significativo ônus ao sistema de saúde, configurando problema de saúde pública. Apesar das baixas taxas de mortalidade e de rara ocorrência de metástases, o tumor pode apresentar comportamento invasivo local e recidivas após o tratamento, provocando importante morbidade. Exposição à radiação ultravioleta representa o principal fator de risco ambiental associado a sua gênese. Entretanto, descrevem-se outros elementos de risco: fotótipos claros, idade avançada, história familiar de carcinomas de pele, olhos e cabelos claros, sardas na infância e imunossupressão, além de aspectos comportamentais, como exercício profissional exposto ao sol, atividade rural e queimaduras solares na juventude. Entre 30% e 75% dos casos esporádicos estão associados à mutação do gene patched hedgehog, mas outras alterações genéticas são ainda descritas. A neoplasia é comumente encontrada concomitantemente com lesões cutâneas relacionadas à exposição solar crônica, tais como: queratoses actínicas, lentigos solares e telangiectasias faciais. A prevenção do carcinoma basocelular se baseia no conhecimento de fatores de risco, no diagnóstico e tratamento precoces e na adoção de medidas específicas, principalmente, nas populações susceptíveis. Os autores apresentam uma revisão da epidemiologia do carcinoma basocelular.Basal cell carcinoma is the most common malignant neoplasm in humans and its incidence has increased over the last decades. Its high frequency significantly burdens the health system, making the disease a public health issue. Despite the low mortality rates and the rare occurrence of metastases, the tumor may be locally invasive and relapse after treatment, causing significant morbidity. Exposure to ultraviolet radiation is the main environmental risk factor

  14. Facies del subfondo del canal Beagle, Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Gustavo Bujalesky

    2004-03-01

    Full Text Available El canal Beagle conecta los océanos Pacífico y Atlántico en el extremo meridional de Sudamérica y se ubica en el ambiente subantártico. Conforma una cuenca de unos 300 m de profundidad máxima y está separada del océano Atlántico por un umbral de 30 m de profundidad. El canal es un valle tectónico que fue completamente cubierto por el hielo glacial durante la última glaciación. Posteriormente, el canal fue ocupado por un lago glacial desde los 12.000 a los 8.000 años A.P., cuando fue invadido por el mar que alcanzó un nivel máximo entre los 6.000 y 5.000 años A.P. Con el objetivo de analizar las facies sedimentarias superficiales y del subfondo del canal se realizó un relevamiento geofísico con sonar de barrido lateral y un perfilador de 3,5 kHz. Sobre un basamento constituido por rocas metamórficas del Mesozoico, se identificaron depósitos de till y secuencias granodecrecientes que representan distintos estadios del retroceso glaciar, evidenciando hacia la sección superior facies lacustres y por encima depósitos de la transgresión marina del Holoceno. Además, se han identificado paleocauces y secuencias fluviales cubiertas por sedimentos marinos transgresivos.

  15. Odontogenic Carcinoma with Dentinoid: A New Odontogenic Carcinoma

    OpenAIRE

    Mosqueda-Taylor, Adalberto; Brad W Neville; Tatemoto, Yukihiro; Ogawa, Ikuko; Takata, Takashi

    2014-01-01

    Dentinoid is an integral part of some odontogenic tumors. This article describes the clinico-pathological features of three cases of odontogenic carcinomas with dentinoid (OCD). A comparison of these with previously reported cases of dentinoid-producing epithelial odontogenic tumors allowed us to identify another six cases that may be considered as examples of OCD. Six cases occurred in the mandible and three in the maxilla, all developing behind the canines. There was no sex predilection (fi...

  16. Carcinoma basocelular metastásico en la región parotídea: un nuevo caso Basal cell carcinoma metastatic to the parotid area: case report

    Directory of Open Access Journals (Sweden)

    T. Pérez de la Fuente

    2006-03-01

    Full Text Available El carcinoma basocelular es la tumoración cutánea maligna más frecuente. Junto con el carcinoma espinocelular su localización habitual es a nivel de cabeza y cuello y a diferencia de éste la tasa de metástasis regionales es mucho más baja. Presentamos el caso de una mujer de 85 años con un carcinoma basocelular a nivel del pabellón auricular derecho, que inicialmente se trató mediante extirpación y cierre. A los 2 años presentó recidiva local en la zona inferior del pabellón auricular y en la exploración física se apreció una tumoración dura a nivel submandibular derecho. Se realizó punción aspiración con aguja fina (PAAF que fue positiva para metástasis de carcinoma basocelular. La Tomografía Axial Computerizada (TAC mostraba una masa única en la región submandibular no adherida a la mandíbula. El tratamiento consistió en extirpación de la recidiva local y parotidectomía superficial más vaciamiento cervical funcional del lado derecho. La paciente se negó a realizar tratamiento con radioterapia complementaria. En la actualidad la paciente está viva y realiza revisiones periódicas.Basal cell carcinoma is the most common cutaneous malignancy. As the scamous cell carcinoma its first location is in head and neck, but the rate of regional metastases is much lower. We present the case of an 85-year-old woman with a basal cell carcinoma located on the ear. She was first treated by local excision and direct suture. Two years later presented a local recurrence in the lower part of the ear. At this time a physical neck exam revealed a submandibular node. Fine needle aspiration was positive for basal cell carcinoma metastases, and a Computed Tomography (CT showed a single mass in the submandibular region not in contact with bone. Treatment consisted on a wide local excision, superficial parotidectomy and ipsilateral functional neck dissection. The patient refused postoperative radiotherapy treatment. At this moment the

  17. Estudio del proceso de crecimiento del cultivo del tomate

    OpenAIRE

    Barraza, Fernando V.; Fischer, Gerhard; Cardona, Carlos E.

    2010-01-01

    Para conocer la densidad poblacional óptimay obtener el mayor rendimiento en el cultivo deltomate en el Valle del Sinú medio, se hizo una investigaciónmediante diseño completamente al azar con cuatrotratamientos (densidades poblacionales de 20.000,25.000, 33.333 y 50.000 plantas∙ha -1) y tres repeticiones.Se tomaron las medidas directas: altura de planta, númerode hojas, área foliar, número de frutos y rendimiento.También se calcularon los índices de crecimiento: tasa decrecimiento del cultiv...

  18. La estimulación eléctrica del sistema nervioso central con finalidad analgésica The electrical stimulation of the central nervous system for pain control

    Directory of Open Access Journals (Sweden)

    J. A. López-López

    2006-06-01

    Full Text Available Esta revisión pretende orientar al lector sobre los procedimientos empleados para el control del dolor crónico, preferentemente neuropático, por medio de la electricidad. Historia de la utilización de la electricidad con finalidad analgésica, con descripción de los usos primitivos en el siglo XVIII y su evolución. Estimulación eléctrica medular: Se describen los mecanismos de acción, la selección de los pacientes, las técnicas de implante, la forma de realización de los diferentes procedimientos y sus complicaciones y el manejo de las mismas. Estimulación cerebral: Se sigue el mismo esquema que en el apartado anterior, diferenciándose en dos apartados: la estimulación cerebral profunda y la estimulación de la corteza prefrontal.Different procedures using electricity for pain control (mainly neuropathic are described in this review. History of the so-called utility of electricity for pain control, describing the early attempts at the XVIII century and their evolution. Spinal cord stimulation: How does it works, patient’s selection, implant techniques, how to do the different procedures and complications and their management are described. Brain stimulation: The same scheme as above, concerning both Deep Brain Stimulation and Motor Cortex Stimulation.

  19. Pure compared with mixed serous endometrial carcinoma: two different entities?

    NARCIS (Netherlands)

    Roelofsen, T.; Ham, M.A. van; Wiersma van Tilburg, J.M.; Zomer, S.F.; Bol, M.; Massuger, L.F.A.G.; Bulten, J.

    2012-01-01

    OBJECTIVE: : To analyze whether mixed compared with pure uterine papillary serous carcinoma histology affects clinical outcome, and to assess uterine papillary serous carcinoma for its association with the precursor lesion endometrial intraepithelial carcinoma. METHODS: : A multi-institution observa

  20. Local excision for selected colorectal carcinomas.

    Science.gov (United States)

    Lawrence, M A; Goldberg, S M

    1989-07-01

    In summary, local excision is a useful tool in the management of selected colorectal carcinomas. The advent of the fibreoptic colonoscope has revised the concept of local excision when dealing with carcinoma-containing polyps of the colon. The clinician now has the means of locally excising certain carcinomas which would have required laparotomy in the not so distant past. In dealing with carcinoma of the rectum, local excision is not advocated for all rectal carcinomas. In fact, when the previously discussed tumour related factors are considered, local excision should be the ultimate procedure in less than 5% of operations performed for rectal carcinomas. However, when appropriately used, local excision provides a less morbid alternative to more radical procedures without compromising patient survival rates or local recurrence rates. PMID:2692739

  1. Axillary node metastasis from primary ovarian carcinoma

    Directory of Open Access Journals (Sweden)

    Trupti S Patel

    2014-01-01

    Full Text Available Metastasization and distinction from mammary carcinoma is of great clinical importance because of different treatment modalities. Here, we discuss a case of stage IIIC ovarian serous carcinoma, presenting with bilateral axillary nodes metastasis after 25 months interval of its initial presentation. Increased serum CA-125 level caused clinical suspicion. Computed tomography scan of abdomen and pelvis showed no residual disease or any abdominal lymphadenopathy. Mammography of both breast were normal. Bilateral axillary nodes were noted. Guided fine needle aspiration cytology (FNAC and biopsy of ovarian carcinoma to axillary node is a rare event. Its recogn done. Cytomorphology revealed poorly differentiated carcinoma, compatible to that of primary ovarian tumor. Thus, metastatic carcinoma to axillary node from ovary was confirmed. This case illustrates a rare metastatic presentation of ovarian carcinoma and unequivocal role of FNAC to provide rapid diagnosis and preferred to be first line diagnostic procedure.

  2. Proteomics in Discovery of Hepatocellular Carcinoma Biomarkers

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To discover new proteomic biomarkers of hepatocellular carcinoma. Methods: Surface enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry was used to discover biomarkers for differentiating hepatocellular carcinoma and chronic liver disease. A population of 50 patients with hepatocellular carcinoma and 33 patients with chronic liver disease was studied. Results: Twelve proteomic biomarkers of hepatocellular carcinoma were detected in this study. Three proteomic biomarkers were highly expressed in hepatocellular carcinoma and nine proteomic biomarkers were highly expressed in chronic liver disease. The most valuable proteomic biomarker with m/z=11498 had no similar diagnostic value as α-fetoprotein. Conclusion:Some of the twelve proteomic biomarkers may become new biomarkers of hepatocellular carcinoma.

  3. Renal cell carcinoma: Evolving and emerging subtypes.

    Science.gov (United States)

    Crumley, Suzanne M; Divatia, Mukul; Truong, Luan; Shen, Steven; Ayala, Alberto G; Ro, Jae Y

    2013-12-16

    Our knowledge of renal cell carcinoma (RCC) is rapidly expanding. For those who diagnose and treat RCC, it is important to understand the new developments. In recent years, many new renal tumors have been described and defined, and our understanding of the biology and clinical correlates of these tumors is changing. Evolving concepts in Xp11 translocation carcinoma, mucinous tubular and spindle cell carcinoma, multilocular cystic clear cell RCC, and carcinoma associated with neuroblastoma are addressed within this review. Tubulocystic carcinoma, thyroid-like follicular carcinoma of kidney, acquired cystic disease-associated RCC, and clear cell papillary RCC are also described. Finally, candidate entities, including RCC with t(6;11) translocation, hybrid oncocytoma/chromophobe RCC, hereditary leiomyomatosis and RCC syndrome, and renal angiomyoadenomatous tumor are reviewed. Knowledge of these new entities is important for diagnosis, treatment and subsequent prognosis. This review provides a targeted summary of new developments in RCC. PMID:24364021

  4. Marketing Mix del Software.

    OpenAIRE

    Yudith del Carmen Rodríguez Pérez

    2006-01-01

    La ingeniería del software y los modelos de calidad del software han consolidado sus esfuerzos en el proceso de producción del mismo, sin embargo son pocos sus aportes en el proceso de comercialización. Es esencial en la ciencia de la computación desarrollar un modelo de comercialización para las organizaciones productoras de software con el fin de elevar la productividad de las mismas. Sin embargo, es preciso primero conocer las características del producto software que los diferencian de ot...

  5. Los sentimientos del Cid

    OpenAIRE

    Aurelio González

    2007-01-01

    Un recorrido por los sentimientos que se han plasmado en la caracterización del personaje del Cid conlleva el análisis de las formas expresivas, que se utilizan para que estos sentimientos sean verosímiles, sin entrar en contradicción con la condición heroica y épica del personaje. La consideración de las expresiones de tristeza, alegría, devoción o gratitud de Rodrigo permite identificar estrategias discursivas del poema que intentan acercar al receptor a una valoración positiva de la baja n...

  6. Estudio del léxico del Ecuador

    OpenAIRE

    Estrella Santos, Ana Teresa

    2008-01-01

    El presente trabajo de investigación pretende proporcionar una descripción del léxico del español del Ecuador, a partir de materiales de la lengua hablada. Hemos llevado a cabo un análisis contrastivo del léxico de las provincias de Pichincha y Guayas, una recopilación del léxico general del Ecuador y un análisis de los quichuismos presentes en nuestro corpus.

  7. Riesgos laborales en trabajadores del sector informal del Cauca, Colombia

    OpenAIRE

    Augusto Muñoz-Caicedo; Pilar Mirely Chois-Lenis

    2014-01-01

    Antecedentes. Un estudio a nivel nacional permitió establecer los riesgos a los cuales estaban expuestos los trabajadores del sector informal del comercio. Sin embargo, no fue incluido el Departamento del Cauca. Objetivo. Describirlos riesgos laborales de las personas ocupadas en el sector informal del comercio, en cinco municipios del departamento del Cauca, durante el 2011. Materiales y métodos. Estudio descriptivo, transversal, desarrollado con 223 sujetos a quienes se les aplicó una encue...

  8. Scalp squamous cell carcinoma in xeroderma pigmentosum

    OpenAIRE

    Awan, Basim A; Hanadi Alzanbagi; Osama A Samargandi; Hossam Ammar

    2014-01-01

    Context: Xeroderma pigmentosum is a rare autosomal-recessive disorder that appears in early childhood. Squamous cell carcinoma is not uncommon in patients with xeroderma pigmentosum and mostly involving the face, head, neck, and scalp. However, squamous cell carcinoma of the scalp may exhibit an aggressive course. Case Report: Here, we present a huge squamous cell carcinoma of the scalp in a three-years-old child with xeroderma pigmentosum. In addition, we illustrate the challenges of a child...

  9. Unusual Presentation of Cystic Papillary Thyroid Carcinoma

    OpenAIRE

    Patil, Vijayraj S.; Abhishek Vijayakumar; Neelamma Natikar

    2012-01-01

    Papillary thyroid carcinoma is the most common thyroid malignancy, accounting for 80% of all thyroid cancers. The most common presentation of thyroid cancer is an asymptomatic thyroid mass or a nodule. Usually as thyroid enlarges, it extends in to mediastinum. Papillary thyroid carcinoma presentation as multiple true cystic swelling extending from neck to anterior chest wall in subcutaneous plane is not present in the literature. We present a rare case of cystic papillary thyroid carcinoma wh...

  10. Renal Clear Cell Carcinoma and Tonsil Metastasis

    OpenAIRE

    Dario Marcotullio; Giannicola Iannella; Gian Franco Macri; Caterina Marinelli; Melissa Zelli; Giuseppe Magliulo

    2013-01-01

    Renal cell carcinoma is the most common renal tumor in adults. Clear cell carcinoma represents 85% of all histological subtypes. In February 2012 a 72-year-old woman came to our department due to the appearance of massive hemoptysis and pharyngodinia. Previously, this patient was diagnosed with a renal cell carcinoma treated with left nephrectomy. We observed an exophytic, grayish, and ulcerated mass in the left tonsillar lodge and decided to subject the patient to an immediate tonsillectomy....

  11. Clear cell carcinoma of the lung.

    OpenAIRE

    Edwards, C; Carlile, A

    1985-01-01

    Six tumours of the lung initially classified as clear cell carcinoma, were studied. Examination of further material by light and electron microscopy showed adenocarcinomatous differentiation in three cases and squamous differentiation in two. One case showed the features of a large cell anaplastic carcinoma. The clear appearance of the cytoplasm in paraffin sections was due to accumulations of glycogen that were partially removed during processing. It is concluded that clear cell carcinoma is...

  12. Small Cell Carcinoma of the Bladder

    OpenAIRE

    Çiçek, Tufan; Coşkunoğlu, Esra Zeynep; Duran, Berkan; Çiftci, Egemen

    2015-01-01

    Small Cell Carcinoma of the bladder accounts for less than 1% of all bladder tumors. Small Cell Carcinoma of the bladder has an aggressive behaviour and is usually metastatic at diagnosis. Due to its infrequent occurence, the literature on this entity is limited; which unsurprisingly leads to an uncertanity in defining an ideal therapeutic approach. This report, overviews the literature while describing a 70- year- old female patient who is diagnosed with small cell carcinoma of the bladder a...

  13. Small Cell Carcinoma of the Bladder

    OpenAIRE

    Tufan Cicek; Esra Zeynep Coskunoglu; Berkan Duran; Egemen Ciftci

    2015-01-01

    Small Cell Carcinoma of the bladder accounts for less than 1% of all bladder tumors. Small Cell Carcinoma of the bladder has an aggressive behaviour and is usually metastatic at diagnosis. Due to its infrequent occurence, the literature on this entity is limited; which unsurprisingly leads to an uncertanity in defining an ideal therapeutic approach. This report, overviews the literature while describing a 70- year- old female patient who is diagnosed with small cell carcinoma of the bladder ...

  14. Synchronous Squamous Cell Carcinoma in Multiple Digits

    OpenAIRE

    Abner, Sabra; Redstone, Jeremiah; Chowdhry, Saeed; Kasdan, Morton L.; Wilhelmi, Bradon J.

    2011-01-01

    Cancers of the perionychium are relatively rare occurrences and are often related to chronic inflammation associated with trauma, infection, exposure to ultraviolet radiation, or other carcinogens. Squamous cell carcinoma is the most common tumor reported of the nail bed. Synchronous squamous cell carcinomas of the perionychium have been rarely reported. We present a case of a 46-year-old woman with synchronous squamous cell carcinomas involving both hands and multiple digits. Treatment modal...

  15. Merkel Cell Carcinoma Concurrent with Bowen's Disease

    OpenAIRE

    Park, Hyun Chul; Kang, Ho Song; Park, Kyoung Tae; Oh, Young Ha; Yu, Hee Joon; Kim, Joung Soo

    2012-01-01

    Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy of the elderly and immunocompromised patients. It is occasionally found coexisting with other diseases, such as squamous cell carcinoma, basal cell carcinoma, actinic keratosis, miscellaneous adnexal tumors, and rarely Bowen disease. A 75-year-old woman presented with a 6-month history of an irregularly shaped erythematous patch on the left mandibular angle. Three months later, a 1.5×1.0 cm sized painless and rapidly growi...

  16. Overexpression of vimentin in canine prostatic carcinoma

    DEFF Research Database (Denmark)

    Rodrigues, M M P; Rema, A; Gärtner, F;

    2011-01-01

    associated with the invasive phenotype of human prostate cancer cells. The aim of the present study was to characterize immunohistochemically the expression of vimentin by canine prostatic carcinomas. Primary carcinomas and metastatic tumour foci both showed vimentin expression. This finding suggests that...... the acquisition of the epithelial-mesenchymal transition phenotype in canine prostatic carcinoma may be characterized by the presence of mesenchymal intermediate filament (vimentin) that could lead to a higher likelihood of metastasis....

  17. Breed predisposition to canine gastric carcinoma

    DEFF Research Database (Denmark)

    Seim-Wikse, Tonje; Jörundsson, Einar; Nødtvedt, Ane;

    2013-01-01

    Previous research has indicated a breed predisposition to gastric carcinoma in dogs. However, results to date are inconsistent since several studies have failed to prove such a predisposition. Better knowledge of breeds at risk could facilitate early detection of gastric carcinoma in dogs. The aim...... of the study was to retrospectively investigate the proportion and possible breed predisposition to canine gastric carcinoma using the Norwegian Canine Cancer Register for calculations of proportional morbidity ratios (PMRs) for the period 1998-2009....

  18. Case of hereditary papillary renal cell carcinoma

    OpenAIRE

    Mustafa, Sadaf; Jadidi, Nima; Faraj, Sheila F.; Rodriquez, Ronald

    2012-01-01

    Renal cell carcinoma is the most common type of renal malignancy and it originates from the renal tubular epithelium. Due to the diversity in the histopathological and molecular characteristics, it is typically subclassified into five different categories. Papillary renal cell carcinoma is one subclassification and it includes two variants: sporadic and hereditary. Although the hereditary form comprises a smaller number of cases of papillary renal cell carcinoma, an understanding of the molec...

  19. Neglected Giant Scalp Basal Cell Carcinoma

    OpenAIRE

    Anne Kristine Larsen, MD; Waseem-Asim Ghulam El-Charnoubi, MD; Julie Gehl, MD, PhD; Christen Krag, MD, PhD

    2014-01-01

    Summary: Rarely, basal cell carcinoma grows to a giant size, invading the underlying deep tissue and complicating the treatment and reconstruction modalities. A giant basal cell carcinoma on the scalp is in some cases treated with a combination of surgery and radiation therapy, resulting in local control, a satisfactory long-term cosmetic and functional result. We present a case with a neglected basal cell scalp carcinoma, treated with wide excision and postoperative radiotherapy, reconstruct...

  20. Modelo pronóstico multidimensional en carcinoma broncogénico no microcítico resecado

    OpenAIRE

    Alonso Moralejo, Rodrigo

    2012-01-01

    Introducción: En la célula tumoral existen cambios en la vía del metabolismo energético, participando en la célula eucariota la mitocondria de forma fundamental. En la actualidad se considera que la estimación de la supervivencia en el Carcinoma Broncogénico (CB) está basada fundamentalmente en los descriptores de extensión anatómica (clasificación TNM), aunque existen otras variables que también influyen en la valoración pronóstica. Objetivo: El objetivo del estudio actual es determinar el v...

  1. DNA methylation in hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Iris Tischoff; Andrea Tannapfel

    2008-01-01

    As for many other tumors, development of hepatocellular carcinoma (HCC) must be understood as a multistep process with accumulation of genetic and epigenetic alterations in regulatory genes, leading to activation of oncogenes and inactivation or loss of tumor suppressor genes (TSG). In the last decades, in addition to genetic alterations, epigenetic inactivation of (tumor suppressor) genes by promoter hypermethylation has been recognized as an important and alternative mechanism in tumorigenesis. In HCC, aberrant methylation of promoter sequences occurs not only in advanced tumors, it has been also observed in premalignant conditions just as chronic viral hepatitis B or C and cirrhotic liver. This review discusses the epigenetic alterations in hepatocellular carcinoma focusing DNA methylation.

  2. PANCREATIC CARCINOMA: REVIEW OF LITERATURE

    Directory of Open Access Journals (Sweden)

    Veena Kumari

    2015-05-01

    Full Text Available It is well known that the prognosis of pancreatic cancer is extremely poor, even when treated with radical surgery. The overall 5 year survival rate following surgical intervention is around 10%.With the increasing use of CT scans for other reasons not related to pancreas, a variety of neoplastic and non - neoplastic lesions are increasingly encountered in clinical practice. The distinction of these lesions has significant therapeutic and prognostic implications. Regarding ductal carcinoma, key distinguishing features from chronic pancreatitis and a discussion of the concept of pancreatic intraepithelial neoplasia ( PanIN are included. Precursors, mo lecular carcinogenesis, risk factors and different morphological patterns of tumors arising from exocrine pancreas are discussed. Research on early detection is ongoing. Screening of people with a family history of hereditary pancreatitis plays an importan t role in the early detection of ductal carcinoma of pancreas.

  3. Carcinoma in accessory axillary breast.

    Science.gov (United States)

    Khanna, Seema; Mishra, Shashi Prakash; Kumar, Satendra; Khanna, Ajay Kumar

    2015-01-01

    We present a rare case of carcinoma developing in an accessory breast. The patient presented with a progressive lump in her right axilla for 1 year. On examination, there was a well-developed nipple areola complex in the right axilla overlying a hard, fixed 5 × 3 cm lump. On investigation, core biopsy revealed poorly differentiated carcinoma of the breast. Mammography also revealed features of a malignant lesion with skin and muscle infiltration. Neoadjuvant chemotherapy was administered followed by modified radical mastectomy after three cycles. Immunohistochemistry study showed positive status of oestrogen and progesterone receptors, and negative HER-2 neu. Three more cycles of chemotherapy along with 50 Gy radiotherapy were given in an adjuvant setting followed by hormone therapy. PMID:26260957

  4. Thyroid carcinomas of Belarussian children

    International Nuclear Information System (INIS)

    The incidence of thyroid carcinoma increases significantly following exposure to ionizing irradiation. However, the mechanisms of radiation-induced tumorigenesis at the molecular and chromosomal levels have not been identified. In order to gain some indication of the processes affecting the thyroid epithelium, cytogenetic and molecular genetic investigations were performed on childhood thyroid carcinomas that developed after the Chernobyl nuclear accident in Belarussia, and on secondary thyroid tumours that developed after radiotherapy. At the cytogenetic level, the radiation-induced tumours were shown to have an increased frequency of translocations, multiple and complex chromosome aberrations, and novel breakpoints for structural chromosome aberrations. At the molecular level, different alterations of the RET protooncogene were detected in 65% of the Belarussian tumours. (orig.)

  5. Sebaceous carcinoma. Presenting a case

    International Nuclear Information System (INIS)

    Patient of feminine sex of 65 years of age with tumor of approximately 1.5 cm of diameter, located in the right palpebral region, being put under ample exeresis of a tumor more pastia, whose anatomopathology result revealed sebaceous carcinoma with free edges. This is a rare malignant carcinoma that originates in perioculars sebaceous glands like the glands of Meibomio that affects the superior flicker. Clinically it appears like a small nodule, of small growth and its diagnose is based on a high degree of suspicion in any chronic process of the flicker. The selection processing is the surgery, the x-ray, radiotherapy is useful in the postoperating attention and like palliative therapy. (The author)

  6. [Cytostatic treatment of ovarian carcinoma].

    Science.gov (United States)

    Neijt, J P

    1999-10-30

    Shortly after treatment with the cytostatic combination of cisplatin and paclitaxel was generally accepted as the standard therapy for patients with epithelial ovarian carcinoma, many have come to regard the combination of carboplatin and paclitaxel as a better choice. The latter combination causes fewer side effects and may be used in the outpatient clinic. Conceivably, the carboplatin-paclitaxel scheme will shortly have to be adjusted again owing to results of current research. The intensive basic research of recent years, namely, is beginning to yield benefits for the therapeutic arsenal against ovarian carcinoma. Possibilities are inhibitors of the breakdown of extracellular matrix (such as marimastat) and inhibitors of signal transduction (such as trastuzumab). PMID:10578409

  7. Management of Recurrent Endometrial Carcinoma.

    OpenAIRE

    Ming-Shian Kao

    2004-01-01

    Management of recurrent endometrial carcinoma has traditionally focused on providingtargeted adjuvant therapy in select groups of patients based on their risk factors. Majorprogress has been made over the last two decades in identifying these clinical-pathologicalrisk factors, which has led to the classification of patients into different risk groups. Patientswith high-risk factors are generally treated with adjunctive radiation therapy immediatelyfollowing surgery to minimize the incidence o...

  8. Inflammatory carcinomas of the breast.

    OpenAIRE

    Anderson, J. M.

    1980-01-01

    Only 4.4% of patients with inflammatory carcinomas of the breast survive 5 years. The incidence of the disease is fortunately low at less than 2% of all mammary malignancies, and there is no relationship to pregnancy or lactation. Clinical diagnosis should be supplemented by searches for microscopic metastases in dermal lymphatics and for distant metastases before a therapeutic programme is planned. Combinations of local and systemic treatments best suited to each individual should be devised...

  9. Thyroid carcinoma and hot nodule

    Energy Technology Data Exchange (ETDEWEB)

    Fukata, Shuji; Tamai, Hajime; Matsubayashi, Sunao; Nagai, Keisuke; Hirota, Yoshihiko; Matsuzuka, Fumio; Katayama, Shoichi; Kuma, Kanji; Nagataki, Shigenobu

    1987-09-01

    A 70-year-old woman presented with a nodule in the thyroid gland. /sup 131/I scintigraphy of the gland showed a hot nodule. Histology of the resected thyroid revealed a papillary adenocarcinoma. Although a thyroid carcinoma with a hot nodule seen on the radioiodine isotope scan is a very rare occurrence, it is clinically very important because it may indicate a thyroid malignancy.

  10. Clinical guideline SEOM: hepatocellular carcinoma

    OpenAIRE

    Sastre, J.; Díaz-Beveridge, R.; García-Foncillas, J; Guardeño, R.; C. López; Pazo, R.; Rodriguez-Salas, N.; Salgado, M; Salud, A; Feliu, J

    2015-01-01

    Hepatocellular carcinoma (HCC) represents the second leading cause of cancer-related death worldwide. Surveillance with abdominal ultrasound every 6 months should be offered to patients with a high risk of developing HCC: Child-Pugh A–B cirrhotic patients, all cirrhotic patients on the waiting list for liver transplantation, high-risk HBV chronic hepatitis patients (higher viral load, viral genotype or Asian or African ancestry) and patients with chronic hepatitis C and bridging fibrosis. Acc...

  11. Primary carcinoma of the vagina.

    Science.gov (United States)

    Lilic, V; Lilic, G; Filipovic, S; Visnjic, M; Zivadinovic, R

    2010-01-01

    In this paper we reviewed the risk factors for primary carcinoma of the vagina (PCV), diagnostic and therapeutic modalities, and principles leading to rational decision-making in the individualized management of vaginal carcinoma patients. The review was based on the recent literature and our own years- long experience with the disease. PCV is a rare gynecologic malignancy accounting for about 2% of all neoplasms of the female genitals. Most of the affected women are over 60 years of age, peaking between 70 and 80 years. Only 10-15% of patients are below 50 years. Histopathologically, most common are squamous cell carcinoma (80-90%) and adenocarcinoma (4-10%). The leading risk factor for vaginal intraepithelial neoplasia (VAIN) and subsequent squamous cell vaginal carcinoma is long-lasting infection with human papillomavirus (HPV) type 16. Prognosis of the disease depends on several factors, the most important of which are age, histologic type, and tumor stage. Survival depends on the disease stage. Five -year survival rates are about 95% for stage 0, 75% for stage I, 60% for stage II, 35% for stage III, 20% for stage IVa, and 0% for IVb stage. Due to its being a rare entity, there are still controversies as to the most optimal treatment. Individualized treatment approaches have been increasingly used. In most centres, standard treatment for this cancer is radiotherapy. Some reports have shown that surgery might also be an option, while in some centres radiation is supplemented by cisplatin-based chemotherapy. The supposed advantage of radiotherapy is the preservation of the anatomy and function of the vagina. We believe that there are certain psychologic benefits with the preservation of the vagina, regardless of its function. However, preservation of the vaginal function after treatment of invasive vaginal cancer is a rare phenomenon, both in the literature and from our own experience. PMID:20658716

  12. Children thyroid carcinoma and Chernobyl accident

    International Nuclear Information System (INIS)

    In Nuclear medicine diagnostic department of Kaunas Medical University Clinics 22 children (6-16 years of age), ill with thyroid carcinoma were examined. Bas ing on the data of Kaunas Medical University Clinic the incidence of children thyroid carcinoma did not increase after Chernobyl accident. Ratio of boys and girls was 4.5:1. Differentiated thyroid carcinoma was detected in 15 (68.2%)children, mixed carcinoma - 4 (18.2%), nondiferenciated -3 (13.6%) children. First stage of cancer was detected only in one patient (4.5%), second -16 (72.7%), third - 3 (13.6%), fourth stage - 2 (9.1%) patients. (author)

  13. Non-surgical management of hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Most of patients with hepatocellular carcinoma (HCC) cannot benefit from surgical therapies. Among non-surgical options, only radiofrequency can challenge surgery for small size tumours. Conformal radiotherapy is likely highly efficient on solitary tumours, but controlled studies are warranted to conclude. Other options are purely palliative. Trans-arterial hepatic chemo-embolization is the goal-standard for multifocal hepatocellular carcinoma and Sorafenib for hepatocellular carcinoma with portal vein invasion, leading to modest but significant benefit on survival rates. Yttrium-90 radio-embolization is under evaluation through controlled studies, and could be of major interest for multifocal hepatocellular carcinoma with or without portal venous invasion. (authors)

  14. Intrathyroidal parathyroid carcinoma: A case report

    Energy Technology Data Exchange (ETDEWEB)

    You, Woo Young; Han, You Mie; Choi, Young Hee [Hallym University College of Medicine, Dongtan Sacred Heart Hospital, Hwaseong (Korea, Republic of)

    2015-05-15

    Parathyroid carcinoma is an uncommon malignancy and a rare cause of primary hyperparathyroidism. Intrathyroidal parathyroid carcinoma is even rarer and only few cases have been reported previously. A 33-year-old woman presented with hypercalcemia. CT scan revealed a 5-cm sized intrathyroid nodule with a positive beak sign on the surface in contact with the thyroid gland. The patient underwent total thyroidectomy, and the histopathologic examination confirmed the diagnosis of parathyroid carcinoma. We report a case of intrathyroidal parathyroid carcinoma with brief literature review.

  15. Sclerosing Mucoepidermoid Carcinoma; A unique case

    Directory of Open Access Journals (Sweden)

    Keshava Bhat

    2014-05-01

    Full Text Available Sclerosing mucoepidermoid carcinoma is an unusual type of mucoepidermoid carcinoma with special histological features which differ from those of the classic type of mucoepidermoid carcinoma. We report the case of a 32-year-old male, who reported to the Vydehi Institute of Dental Sciences, Bangalore, India, with an asymptomatic swelling over the right parotid region which had been present for the previous two and a half years. Histopathological sections of the tumour mass showed mucous and epidermoid cell nests in a dense, hyalinised, sclerotic stroma. A diagnosis of sclerosing mucoepidermoid carcinoma was made. A superficial parotidectomy was performed on the patient and he has remained disease free to date.

  16. Verrucous carcinoma - report on two cases

    Directory of Open Access Journals (Sweden)

    Padmavathy L

    2009-01-01

    Full Text Available Squamous cell carcinoma is a common malignant tumor of the keratinizing cells of the epidermis. Verrucous carcinoma or Ackerman′s tumor is a subtype of low grade squamous cell carcinoma that can affect cutaneous and mucous surfaces. Two cases of Verrucous carcinoma affecting the lip and oral mucous membrane (oral florid papillomatosis are being reported. One patient had a co-existent sub mucous fibrosis, a pre-malignant lesion and two auto-immune disorders, i.e., diabetes mellitus and vitiligo.

  17. Squamous Cell Carcinoma of the Pancreas

    Directory of Open Access Journals (Sweden)

    Andre Luiz De Souza

    2014-11-01

    Full Text Available We previously published our and Johns Hopkins data titled: "Platinum-based therapy in adenosquamous pancreatic cancer: experience at two institutions” [1]. We will here like to submit a related case report as a letter to the editor to JOP in reference to the above paper. Squamous cell carcinoma of the pancreas has various reported incidence rates, ranging from 0.5% to as high as 5% of pancreatic ductal carcinomas [2, 3]. Of the 1300 cases of pancreatic cancers observed at autopsy in a survey in Japan in 1992, 0.7% were squamous cell carcinoma [4]. A Mayo clinic review of very rare exocrine tumors showed an even rarer incidence of squamous cell carcinoma when compared to acinar and small cell carcinoma of the pancreas [5]. This discrepancy in the reported incidence rates related to the fact that some of the cases represent adenosquamous carcinoma rather than pure squamous cell carcinoma of pancreas. In an analysis of 25 patients, mean age at diagnosis of pancreatic squamous cell carcinoma was 62 years (range: 33–80 years and there was no gender difference [6]. There is no study about the molecular profile of squamous carcinoma of the pancreas. There are no retrospective or prospective studies about the best therapy for these tumors

  18. Definition of early carcinoma of the stomach

    International Nuclear Information System (INIS)

    At the annual meeting of JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY in 1962 and of JAPANESE RESEARCH SOCIETY for GASTRIC CANCER in 1963, the early gastric carcinoma was defined as carcinoma of the stomach of which invasion was limited to the mucosa and submucosa. In applying this classification, the histogenesis of carcinomas should not be considered. The difference between type IIc and type III is that the depression of the latter is limited beyond the submucosa. When a carcinoma shows diverse morphological patterns, 2 or more types are desribed together, e. g. type III + IIc or IIc + III. The first Roman numeral indicated the predominant pattern

  19. Immunotherapy in renal cell carcinoma.

    Science.gov (United States)

    Bukowski, R M

    1999-06-01

    Patients with metastatic renal cell carcinoma continue to present a therapeutic challenge. Current therapeutic approaches involve surgery and various types of immunotherapy. The rationale for this latter form of therapy include the observations of spontaneous tumor regression, the presence of a T-cell-mediated immune response, and the tumor responses observed in patients receiving cytokine therapy. Analysis of prognostic factors in these patients demonstrates that clinical responses occur most frequently in individuals with good performance status. The cytokines interleukin-2 (IL-2, aldesleukin [Proleukin], interferon-alfa (Intron A, Roferon-A), or the combination produce responses in 15% to 20% of patients. Randomized trials suggest that administration of interferon-alfa may result in a modest improvement in median survival. Investigation of the molecular genetics of renal cell carcinoma and the presence of T-lymphocyte immune dysregulation have suggested new therapeutic strategies. Further preclinical and clinical studies investigating inhibitors of angiogenesis or pharmacologic methods to reverse immune dysregulation are ongoing. Therapeutic results in patients with renal cell carcinoma remain limited, and investigational approaches are warranted. PMID:10378218

  20. Carcinoma mucoepidermoide central de la mandíbula, en un paciente con displasia fibrosa quística mandibular

    Directory of Open Access Journals (Sweden)

    Ángel Lazo- Valladares

    2006-10-01

    Full Text Available El carcinoma mucoepidermoide de glándula salival es un tumor frecuente; constituye el 15% de los tumores de dicha estructura. Sin embargo, en la mandíbula son mucho menos frecuentes (menos de 200 casos reportados y se le conoce como carcinoma mucoepidermoide central. La patogenia de este tumor intraóseo sigue siendo controversial. Al igual que otros carcinomas intaóseos primarios, puede tener varios orígenes: 1 atropamiento de glándulas mucosas retromolares en la mandíbula, 2 epitelio del seno maxilar, 3 atropamiento iatrogénico de glándula salival menor (ej. en una osteomielitis o sinusitis crónica, 4 remanentes de lámina dental, 5 remanentes de tejido de glándula salival en la mandíbula, 6 transformación neoplásica de células mucosecretoras en el epitelio de revestimiento de quistes odontogénicos. Se presenta el caso de un hombre con un carcinoma mucoepidermoide central de la mandíbula y se hace una revisión del tema.

  1. Sarcomatoid carcinoma with small cell carcinoma component of the urinary bladder: a case report with review of the literature

    OpenAIRE

    ISHIDA, MITSUAKI; Iwai, Muneo; Yoshida, Keiko; Kagotani, Akiko; OKABE, HIDETOSHI

    2013-01-01

    Sarcomatoid carcinoma of the urinary bladder is an uncommon neoplasm characterized histopathologically by the presence of malignant spindle cell and epithelial components. Albeit extremely rare, sarcomatoid carcinoma with small cell carcinoma has been reported. Herein, we describe an additional case of sarcomatoid carcinoma with small cell carcinoma and squamous cell carcinoma of the urinary bladder and review the clinicopathological features of this type of tumor. An 82-year-old Japanese mal...

  2. The Expression of p53 and Cox-2 in Basal Cell Carcinoma, Squamous Cell Carcinoma and Actinic Keratosis Cases

    OpenAIRE

    Ülker KARAGECE YALÇIN; Selda SEÇKİN

    2012-01-01

    Objective: The aim of this study was to investigate p53 and COX-2 expressions in basal cell carcinoma, squamous cell carcinoma and actinic keratoses, and to determine a possible relationship.Material and Method: 50 basal cell carcinoma, 45 squamous cell carcinoma and 45 actinic keratosis cases were evaluated. The type of tumor in basal cell carcinoma and tumor differentiation in squamous cell carcinoma were noted and the paraffin block that best represented the tumor was chosen. Immunostainin...

  3. Cartas del Observatorio N° 2

    OpenAIRE

    Castell, Edmon; Torres Carreño, Guillermo Andrés; Diazgranados, Carlos Nicolás; Mora, Yaneth

    2011-01-01

    El boletín del OAN, "Cartas del Observatorio", es una pieza de comunicación desarrollada entre el Observatorio Astronómico Nacional (OAN) y el Área de Comunicación del SPM. El boletín periódico forma parte de los aportes del SPM al Bicentenario de la Independencia (2010) de Colombia. Este segundo número de Cartas del Observatorio, describe la construcción del edificio, el plan museológico por parte del SPM, una de las piezas importante del OAN, la publicación de la infografía y la partici...

  4. La luz del origen del universo

    Directory of Open Access Journals (Sweden)

    Casas, Alberto

    2015-10-01

    Full Text Available Penzias and Wilson discovered the cosmic microwave background, a luminous echo of the Big Bang, in 1965. The amount of information encoded in this relic of the early universe is truly extraordinary. At present, the most precise data about the origin and structure of the universe comes from the study of this primordial light, the full potential of which has yet to be explored.En 1965 se descubrió el fondo de radiación de microondas, un eco luminoso de la Gran Explosión (Big Bang. La cantidad de información contenida en esta reliquia del universo primitivo es verdaderamente extraordinaria. En la actualidad los datos más precisos sobre el origen y estructura del universo provienen del estudio de esta luz primigenia, que aún no ha sido explorada en todo su potencial.

  5. El equilibrio del consumidor

    OpenAIRE

    León Rodríguez, Mª Dolores; Fernández Pérez, Ana Mª

    2008-01-01

    Obtencin de la recta presupuestaria de un consumidor. Definición y características de las Curvas de indiferencia. Concepto de relación marginal de sustitución. Obtención del equilibrio del consumidor

  6. Differential Diagnosis of a Follicular Carcinoma and Papillary Carcinoma of the Thyroid Gland Based on Sonographic Findings

    Energy Technology Data Exchange (ETDEWEB)

    Yi, Kyung Sik; Bae, Il Hun; Lee, Seung Young; Jeon, Min Hee [Chungbuk National University College of Medicine, Cheongju (Korea, Republic of)

    2007-12-15

    The purpose of this study was to evaluate and compare the sonographic findings of a conventional papillary carcinoma, follicular carcinoma and a follicular variant of a papillary carcinoma. A total of 308 nodules from 231 patients that were diagnosed with a papillary carcinoma and a follicular carcinoma by surgery after sonography were analyzed. The nodules consisted of a conventional papillary carcinoma (255, 83%), a follicular variant of a papillary carcinoma (25, 8%), and a follicualar carcinoma (28, 9%). We compared and analyzed the sonographic findings of each nodule for content, margin, echotexture, shape, calcification and halo sign. A conventional papillary carcinoma showed significant different sonographic findings than a follicular carcinoma and a follicular variant of a papillary carcinoma for an ill-defined or well-defined spiculated margin (63.1%), marked hypoechogenicity (85.9%) and microcalcification (49%). A follicular carcinoma showed a significant difference than a conventional papillary carcinoma for a well-defined smooth margin (92.9%), iso, hypo- or hyperechogenicity (89.3%), wider than tall shape (100%) and halo sign (82.1%). The follicular variant of a papillary carcinoma showed similar findings to a follicular carcinoma except for marked hypoechogenicity (44%, p = 0.006) and taller than wide shape (16%, p = 0.027). The follicular carcinoma and follicular variant of a papillary carcinoma showed similar sonographic findings, but findings of a conventional papillary carcinoma were different

  7. MR imaging of mucinous carcinoma of the breast associated with ductal carcinoma in situ: case report

    International Nuclear Information System (INIS)

    A mucinous carcinoma of the breast is an uncommon carcinoma containing mucin that is associated with a mucocele-like tumor or other malignant tumors. We report the MR imaging findings of two cases, a mucinous carcinoma and ductal carcinoma in situ (DCIS), associated with mucocele-like tumor. The mucinous carcinoma showed a gradually enhancing kinetic pattern on the dynamic MR and high signal intensity on the T2-weighted images. The MR findings were indistinguishable from a common benign mass of the breast

  8. EBV-associated gastric carcinoma in high- and low-incidence areas for nasopharyngeal carcinoma

    DEFF Research Database (Denmark)

    Boysen, T.; Mohammadi, M.; Melbye, M.; Hamilton-Dutoit, S.; Vainer, B.; Hansen, A.V.; Wohlfahrt, J.; Friborg, J.

    2009-01-01

    BACKGROUND: Approximately 10% of gastric carcinomas are associated with Epstein-Barr virus (EBV). The Inuit in Greenland have a high incidence of EBV-associated nasopharyngeal carcinoma. METHODS: We conducted a population-based case-control study comparing gastric carcinomas in Greenland and in D...... Denmark. RESULTS: The prevalence rate of EBV-associated gastric carcinomas was 8.5% in both populations. CONCLUSION: The findings of this study argue against a general susceptibility to EBV-associated carcinomas among the Inuit....

  9. Mixed primary squamous cell carcinoma, follicular carcinoma, and micropapillary carcinoma of the thyroid gland: A case report.

    Science.gov (United States)

    Dong, Su; Song, Xue-Song; Chen, Guang; Liu, Jia

    2016-08-01

    Primary squamous cell carcinoma of the thyroid gland is rare, and mixed squamous cell and follicular carcinoma is even rarer still, with only a few cases reported in the literature. The simultaneous presentation of three primary cancers of the thyroid has not been reported previously. Here we report a case of primary squamous cell carcinoma of the thyroid, follicular thyroid carcinoma, and micropapillary thyroid carcinoma. A 62-year-old female patient presented with complaints of pain and a 2-month history of progressively increased swelling in the anterior region of the neck. Fine-needle-aspiration cytology of both lobes indicated the possibility of the presence of a follicular neoplasm. Total thyroidectomy with left-sided modified radical neck dissection was performed. Postoperative pathological examination confirmed the diagnosis of thyroid follicular carcinoma with squamous cell carcinoma and micropapillary carcinoma of the thyroid. Thyroid-stimulating hormone suppressive therapy with l-thyroxine was administered. Radioiodine and radiotherapy also were recommended, but the patient did not complete treatment as scheduled. The patient remained alive more than 9 months after operation. The present case report provides an example of the coexistence of multiple distinct malignancies in the thyroid. PMID:26589365

  10. Los reptiles del Delta del Orinoco, Venezuela

    OpenAIRE

    Molina, César; Señaris, josefa; Rivas, Gilson

    2004-01-01

    Como resultado de cinco años (1992-1997) de exploraciones herpetológicas, revisiones bibliográficas y examen de museos nacionales, se presenta un análisis taxonómico, ecológico y biogeográfico preliminar de los reptiles del delta del río Orinoco, Estado Delta Amacuro. Se reconocen 70 especies de reptiles agrupados en tres órdenes, 22 familias y 53 géneros. El orden Squamata es el más diverso, con dominancia de las serpientes de la familias Colubridae y Boidae, y los lagartos de las familias G...

  11. Las cosas del quehacer

    OpenAIRE

    Sergio C. Staude

    2010-01-01

    El psicoanálisis es una praxis y no una práctica especulativa que solo busca afianzar un saber. Esta praxis encuentra su eje central en la noción de acto que es la invitación —y el sostén— a una experiencia y no a la acumulación de información. Ese acto da cuenta del tiempo de un pasaje, y el artículo destaca dos: el del momento inaugural del psicoanálisis y el de la función del psicoanalista en el devenir del análisis. A ambas las une la responsabilidad ...

  12. Síndrome de carcinoma basocelular nevoide con agenesia de cuerpo calloso, mutación en PTCH1 y ausencia de carcinoma basocelular

    Directory of Open Access Journals (Sweden)

    Luis D Mazzuoccolo

    2014-08-01

    Full Text Available El síndrome del carcinoma basocelular nevoide (SCBCN o de Gorlin-Goltz es un raro desorden autosómico dominante con un amplio espectro de manifestaciones clínicas. El signo cardinal es la presencia de múltiples carcinomas basocelulares (CBCs y su ausencia demora el diagnóstico. Presentamos un adolescente de 14 años con diagnóstico de SCBCN por la presencia de queratoquistes odontogénicos, hiper­telorismo, macrocefalia y agenesia del cuerpo calloso pero sin lesiones cutáneas. La madre, de 43 años, tiene diagnóstico de SCBCN y no presenta CBCs. Para completar el estudio se realizó secuenciación bidireccional y Multiplex Ligation dependent Probe Amplification (MLPA en sangre periférica para buscar mutaciones en PTCH1, principal gen responsable del síndrome. Se encontró una mutación germinal novel en el paciente y la madre: una duplicación de 25 pb en el exón 10 (c.1375dupl25bp. El análisis bioinformático predijo un corrimiento del marco de lectura y un codón stop prematuro, que produciría una proteína trunca más corta que lo normal. Nuestros resultados sugieren que el estudio clínico y genealógico completo con análisis genético es fundamental para la detección temprana de casos como el presente.

  13. Profundidad tumoral en el carcinoma epidermoide lingual: Repercusiones diagnósticas Tumor depth in squamous cell carcinoma of the tongue: Diagnostic repercussions

    Directory of Open Access Journals (Sweden)

    J.D. Sánchez López

    2007-02-01

    Full Text Available Objetivo. Determinar el grado de concordancia entre la valoración clínica (cT e histopatológica (pT del tamaño del carcinoma epidermoide lingual en relación a la introducción del parámetro de profundidad tumoral (ppT. Material y métodos. 1 Diseño: Estudio retrospectivo de base hospitalaria constituido por 60 pacientes evaluados desde Enero de 1990 a Julio de 1997 (Seguimiento mínimo de 8 años. 2 Variables: Filiación del paciente, parámetros clínicos y parámetros histopatológicos. 3 Método estadístico: Correlación mediante el Indice Kappa (pObjective. To determine the degree of concordance between clinical (cT and histopathological (pT values for tumor size in squamous cell carcinoma when introducing "tumor thickness" as a diagnostic marker. Materials and methods. 1 Design: A retrospective hospital study of 60 patients evaluated between January 1990 and July 1997 was carried out. 2 Variables: Patient dates, clinical and histopathological parameters. 3 Statistics: Correlation assessment by Kappa Index (p<0.05. Results. After the use of "tumor thickness" as a diagnostic indicator the following can be appreciated: • Correlation between cT and ppT: Reduction in the degree of concordance between cT and pT in relation to ppT (23.3 /12.5%. • Correlation between pT and ppT: 100% concordance between pT4 and ppT4. All tumors diagnosed as pT3 were changed to ppT4. Conclusion. When the parameter "tumor thickness" is used, a change can be appreciated in the early stage clinical and histopathological diagnosis, as tumor size (T becomes advanced.

  14. Carcinoma hepatocelular: parte 2. Tratamento Hepatocelular carcinoma: part 2. Therapy

    Directory of Open Access Journals (Sweden)

    Vinício Paride CONTE

    2000-04-01

    Full Text Available São revisadas as formas de tratamento, particularmente as ressecções cirúrgicas, a quimioembolização arterial e as injeções percutâneas de etanol e de ácido acético. Alguns aspectos relativos à dieta, com particular atenção à aflatoxina B1 e aos retinóides, são abordados quanto ao seu desempenho na etiopatogenia e no tratamento da afecção mais comumente encontrada nos países em desenvolvimento. Em relação ao tratamento, fazem-se considerações também referentes ao uso de octreotide, nitrosaminas e outras drogas. A coagulação intersticial a laser e as drogas de ação antivascular também mereceram abordagem sucinta. O problema do carcinoma hepatocelular precoce e a sua destruição é sinalizado de modo sumário. A quimioprevenção com o uso do interferon alfa recombinante considerado e o transplante de fígado encerram a revisão, antes dos comentários finais.Recent improvements on the therapeutical management of hepatocellular carcinoma are revised with special attention to evaluate the role of surgery for the disease. Considering that definitive surgical intervention is not feasible in most cases because of extreme tumor extension, multiplicity of tumor foci, and associated advanced liver cirrhosis at the time of diagnosis, others forms of treatment are listed, such as transcatheterarterial chemoembolization, percutaneous ethanol and acetic acid injections, and chemotherapy only to a small portion of patients with no indication for standard treatments The emerging role of retinoic acid metabolism blocking agents, was examined and may offer a significant new potential treatment for cancer, inclusive the possibility of combining other anticancer drugs with exogenous retinoids or modulation of endogenous retinoids as a real opportunity to advance our ability to treat or prevent human cancer effectively. Octreotide, nitrosamine and other drugs are analyzed and is concluded that improves survival and is a valuable

  15. Focus of tricholemmal differentiation (tricholemmal carcinoma) within Bowen's disease/carcinoma.

    Science.gov (United States)

    Misago, Noriyuki; Toda, Shuji; Nakao, Tomokazu

    2016-04-01

    Bowen's disease (BD)/carcinoma is a type of squamous cell carcinoma of the skin, however, the possibility of adnexal differentiation (the development of sebaceous carcinoma or porocarcinoma) occurring in BD/carcinoma has been suggested. We herein describe a case of BD with superficial invasive carcinoma, which showed a clear cell focus, demonstrating tricholemmal differentiation. This clear cell focus showed the following findings: primarily composed of clear cells, somewhat columnar clear cells aligned in a palisade along a discernible basement membrane, tricholemmal keratinization and glycogen contained within the cells. In addition, the immunohistochemical profile in this clear cell focus, namely, negative staining for cytokeratin (CK)1 and positive staining for CK17 and calretinin in the inner cells of the neoplastic lobule, corresponded to that of the outer root sheath cells. This case suggested that adnexal differentiation can rarely occur within true BD/carcinoma, although adnexal carcinomas are commonly associated with a simple bowenoid change. PMID:26365015

  16. Epidemiologia do carcinoma basocelular Epidemiology of basal cell carcinoma

    OpenAIRE

    Valquiria Pessoa Chinem; Hélio Amante Miot

    2011-01-01

    O carcinoma basocelular é a neoplasia maligna mais comum em humanos e sua incidência vem aumentando nas últimas décadas. Sua grande frequência gera significativo ônus ao sistema de saúde, configurando problema de saúde pública. Apesar das baixas taxas de mortalidade e de rara ocorrência de metástases, o tumor pode apresentar comportamento invasivo local e recidivas após o tratamento, provocando importante morbidade. Exposição à radiação ultravioleta representa o principal fator de risco ambie...

  17. Carcinoma de pulmón de origen laboral Occupational lung cancer

    Directory of Open Access Journals (Sweden)

    M. Pérez de las Casas

    2005-01-01

    Full Text Available El carcinoma broncopulmonar es la primera causa de muerte por cáncer en varones, siendo su principal causa el consumo de tabaco; no obstante, diversos estudios han atribuido un tanto por ciento no despreciable de su etiología a la exposición laboral a agentes considerados cancerígenos como el asbesto, con el que tiene relación la mitad de los casos de cáncer pulmonar de origen laboral. Dada la baja supervivencia de esta patología, son de suma importancia las medidas de prevención encaminadas a identificar los agentes cancerígenos y a la disminución de su exposición. Puesto que la presentación clínica no difiere del carcinoma relacionado con el tabaco, un alto grado de sospecha, basado en una cuidadosa historia laboral, es fundamental para su diagnóstico. Debido el efecto sinérgico del tabaco, medidas destinadas a disminuir su consumo, continúan siendo de suma importancia en la población expuesta.Bronchopulmonary carcinoma is the first cause of death by cancer in males, its principal cause being tobacco consumption. Nonetheless, different studies have attributed a certain, by no means negligible percent of its aetiology to the occupational exposure to agents considered carcinogenic such as asbestos, with which half of the cases of occupational lung cancer are related. Given the low survival rate of this pathology, preventive measures directed at identifying carcinogenic agents and reducing exposure to them are extremely important. Given that the clinical presentation does not differ from tobacco-related carcinoma, a high level of suspicion, based on a meticulous occupational history, is fundamental to its diagnosis. Due to the synergic effect of tobacco, measures aimed at reducing its consumption continue to be extremely important in the exposed population.

  18. Current Aspects on Oral Squamous Cell Carcinoma

    OpenAIRE

    Markopoulos, Anastasios K

    2012-01-01

    Oral squamous cell carcinoma is the most common malignant epithelial neoplasm affecting the oral cavity. This article overviews the essential points of oral squamous cell carcinoma, highlighting its risk and genomic factors, the potential malignant disorders and the therapeutic approaches. It also emphasizes the importance of the early diagnosis.

  19. Radiation induced carcinoma of the middle ear

    International Nuclear Information System (INIS)

    Radiation induced carcinoma of the middle ear is rare. Only four cases have been reported; an additional case is now described. The treatment approach for radiation induced carcinoma of the middle ear has not yet been established. Radiation therapy for advanced cases is discussed as an alternative to surgical treatment. Previous reported cases are reviewed

  20. Chronic inflammatory demyelinating polyneuropathy associated with carcinoma.

    OpenAIRE

    Antoine, J C; Mosnier, J. F.; Lapras, J; Convers, P.; Absi, L; Laurent, B.; Michel, D

    1996-01-01

    The association of chronic inflammatory demyelinating polyneuropathy (CIDP) and carcinoma has rarely been reported and its relevance is debated. Thirty three consecutive patients with probable or definite CIDP (idiopathic or associated with M protein) were investigated. Three patients with definite CIDP had a concomitant carcinoma. One had an IgM paraprotein. Steroids and intravenous immunoglobulins were effective.

  1. Eyelid Carcinoma in Patients with Systemic Lymphoma

    Directory of Open Access Journals (Sweden)

    Debraj Shome

    2010-01-01

    Full Text Available Purpose: To describe a series of patients with Non-Hodgkin′s lymphoma (NHL and concomitant eyelid carcinoma. Methods: In this non-comparative interventional case series, we retrospectively reviewed the medical records of 5 patients with NHL who developed eyelid carcinoma. Results: The patients included one female and four male subjects. Systemic lymphoma had been diagnosed 1 to 72 months prior to development of the eyelid carcinoma. The lesions were basal cell carcinoma in three, and squamous cell carcinoma in two cases. The lymphoma was advanced (stage III or IV in all patients. Four patients underwent surgical excision of the carcinoma and one patient was awaiting surgical treatment after completing systemic chemotherapy. Three subjects had high-grade carcinomas. Two patients had perineural invasion; one received adjuvant radiotherapy postoperatively but the other did not due to receiving systemic chemotherapy for recurrent NHL. Conclusions: Systemic lymphoma may be associated with aggressive eyelid carcinomas. Perineural invasion is frequently encountered in this situation and should be treated with adjuvant radiation therapy to decrease the likelihood of local recurrence.

  2. Renal Cell Carcinoma Presenting as Dysphagia

    OpenAIRE

    Chauhan, Sharad; Yadav, Sher Singh; Tomar, Vinay

    2015-01-01

    Renal cell carcinoma presenting with dysphagia is rare. We report a case who presented with dysphagia as the only manifestations of renal malignancy. Biopsy from the pyriform fossa nodules revealed a clear cell neoplasm. Immuno-histochemical analysis of tissue confirmed metastasis of renal cell carcinoma.

  3. Primary papillary serous carcinoma of the peritoneum

    OpenAIRE

    Madan Mohan Gupta; Bahri, Nandini U.

    2014-01-01

    Primary papillary serous carcinoma of the peritoneum (PSCP) is a rare malignant neoplasm of epithelial origin seen only in women, and closely mimics serous ovarian papillary carcinoma except for the absence of ovarian involvement in PSCP on imaging. It is primarily a peritoneal disease with imaging findings simulated by other conditions that have a predominant peritoneal involvement.

  4. Acinar Cell Carcinoma of the Pancreas

    Institute of Scientific and Technical Information of China (English)

    Hua Li; Qiang Li

    2008-01-01

    Acinar cell carcinoma of the pancreas is a rare tumor which is defined as a carcinoma that exhibits pancreatic enzyme production by neoplastic cells. This review includes re-cent developments in our understanding of the epidemiology and pathogenesis of ACC, imaging and pathological diagnosis and ap-proaches to treatment with reference to the literature.

  5. Examestane in advanced or recurrent endometrial carcinoma

    DEFF Research Database (Denmark)

    Lindemann, Kristina; Malander, Susanne; Christensen, René dePont;

    2014-01-01

    We evaluated the efficacy and safety of the aromatase inhibitor exemestane in patients with advanced, persistent or recurrent endometrial carcinoma.......We evaluated the efficacy and safety of the aromatase inhibitor exemestane in patients with advanced, persistent or recurrent endometrial carcinoma....

  6. Transarterial embolization of metastatic mediastinal hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Chia-Chang Chen

    2013-01-01

    Full Text Available This paper introduces an innovative treatment for extra-hepatic metastasis of hepatocellular carcinoma. A 71-year-old patient had a stable liver condition following treatment for hepatocellular carcinoma, but later developed symptomatic mediastinal metastasis. This rapidly growing mediastinal mass induced symptoms including cough and hoarseness. Serial sessions of transarterial embolization (TAE successfully controlled this mediastinal mass with limited side effects. The patient’s survival time since the initial diagnosis of the mediastinal hepatocellular carcinoma was 32 mo, significantly longer than the 12 mo mean survival period of patients with similar diagnoses: metastatic hepatocellular carcinoma and a liver condition with a Child-Pugh class A score. Currently, oral sorafenib is the treatment of choice for metastatic hepatocellular carcinoma. Recent studies indicate that locoregional treatment of extra-hepatic metastasis of hepatocellular carcinomas might also significantly improve the prognosis in patients with their primary hepatic lesions under control. Many effective locoregional therapies for extrahepatic metastasis, including radiation and surgical resection, may provide palliative effects for hepatocellular carcinoma-associated mediastinal metastasis. This case report demonstrates that TAE of metastatic mediastinal hepatocellular carcinoma provided this patient with tumor control and increased survival time. This finding is important as it can potentially provide an alternative treatment option for patients with similar symptoms and diagnoses.

  7. Current treatments for renal cell carcinoma

    OpenAIRE

    Noble, Helen; Walsh, Ian

    2015-01-01

    Renal cell carcinoma (RCC), also known as kidney cancer, renal adenocarcinoma or hypernephroma, and metastatic renal cell carcinoma is a global burden. This article aims to provide a brief overview of RCC. It outlines epidemiology and presentation; invesitgation and staging; treatments and prognosis. The article also includes a focus on currently available drug treatments, and serves as an introduction to the topic.

  8. Renal cell carcinoma presenting with malignant ascites

    OpenAIRE

    Jennison, Erica; Wathuge, Gayathri W; Gorard, David A

    2015-01-01

    Lesson It is rare for renal cell carcinoma to involve the peritoneum and cause malignant ascites. Furthermore, it is uncommon for malignant ascites to be a presenting feature of this cancer. An unusual case of renal cell carcinoma presenting with malignant ascites is reported, and its response to sunitinib described.

  9. Renal Cell Carcinoma in Transplanted Kidney

    OpenAIRE

    M. Naroienejad; Salouti, R

    2005-01-01

    Immunosuppressive drugs are prescribed routinely to kidney transplant recipients to prevent rejection. These medications are associated wi th an increased risk of secondary malignancies,including renal cell carcinoma in the transplanted kidney itself. We present a case of renal cell carcinoma in a transplanted kidney.

  10. Basal Cell Carcinoma in The Netherlands

    NARCIS (Netherlands)

    S.C. Flohil (Sophie)

    2012-01-01

    textabstractThere are many different cutaneous malignancies, but malignant melanoma, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) represent approximately 98% of all skin cancers.In literature, these three skin cancers are often divided into melanoma and nonmelanoma skin cancers (NMSC

  11. Elementos del sistema electoral del Congreso Mexicano

    Directory of Open Access Journals (Sweden)

    Aldo Medina García

    2013-08-01

    Full Text Available El presente artículo es un estudio de los componentes del sistema electoral, diseñado por el legislador mexicano para integrar al parlamento federal. Estudio desarrollado a sabiendas de la importancia que reviste el sistema electoral como un medio que permite a los ciudadanos convertir su voto expresado en las urnas en escaños a favor de determinado candidato o partido. En dicho análisis tomamos en cuenta la evolución constitucional del sistema electoral mexicano, la participación de las fuerzas minoritarias en la integración del Senado y de la Cámara de Diputados, la división que se hace del territorio en circunscripciones electorales, la barrera electoral que se fija a los partidos políticos para acceder a la representación en el Parlamento, la fórmula de asignación que se aplica a la votación obtenida, para finalmente concluir que el sistema electoral mexicano es esencialmente mayoritario aun cuando se vista de proporcional.

  12. OBJETIVO DEL DESARROLLO DEL MILENIO 7

    Directory of Open Access Journals (Sweden)

    Margarita M. Pérez O.

    2013-10-01

    Full Text Available Los Objetivos de Desarrollo del Milenio, también conocidos como los Objetivos del Milenio, constituyeron las metas finales que aprobaron los dirigentes mundiales, 189 jefes de estado y de gobierno en la Cumbre del Milenio de las Naciones Unidas celebrada en Nueva York en el año 2000, en la cual los Estados miembros de la organización reafirmaron su compromiso de luchar por un mundo en el que el desarrollo sostenible y la eliminación de la pobreza tuvieran máxima prioridad1 . En la cumbre se definió la Declaración del Milenio, la cual detalla los objetivos, principios, valores, metas y acciones para erradicar la pobreza Mundial hacia el año 2015, todos ellos ratificados con alto interés y acción estratégica de carácter global, como marco para la medición de los progresos en materia de desarrollo.

  13. La crisi del diritto del lavoro

    Directory of Open Access Journals (Sweden)

    Alessandro Garilli

    2012-01-01

    Full Text Available Riassunto - L’Autore ripercorre in chiave critica l’evoluzione delle politiche legislative in materia di lavoro, alla luce dell’attuale fase di crisi economico finanziaria. Nell’esaminare i principali interventi normativi attuati da inizio secolo, l’Autore mette in evidenza le scelte di metodo e gli elementi di continuità che accomunano i vari provvedimenti, individuandoli nell’affannosa ricerca del punto di equilibrio tra flessibilità e garantismo. La riflessione si chiude con alcuni interrogativi sulle ultime linee di riforma del mercato del lavoro e con l’auspicio che, anche al cospetto delle imprescindibili ragioni dell’economia, il diritto del lavoro possa continuare a svolgere il proprio tradizionale ruolo di disciplina di tutela della persona.   Abstract - The author analyzes, with a critically oriented approach, the development of the employment law, in the light of the current economic and financial crisis. In examining the main regulatory measures implemented since the beginning of the century, the author highlights the methodological choices and the elements of continuity that unite the various measures, focusing them in a hard research of a point of balance between flexibility and security. The discussion concludes with some questions about the last lines of the reform of the labor market and with the hope that, even in the face of compelling reasons of economy, labor law can continue to play its traditional role of governing the protection of person.

  14. Unusual manifestations of secondary urothelial carcinoma

    Directory of Open Access Journals (Sweden)

    Chaohui Lisa Zhao

    2016-03-01

    Full Text Available High-grade papillary urothelial carcinoma regularly invades the bladder wall, adjacent prostate, seminal vesicles, ureters, vagina, rectum, retroperitoneum, and regional lymph nodes. In advanced stages, it may disseminate to the liver, lungs, and bone marrow. On rare occasions, unusual metastatic foci like skin have been reported. The incidence of urothelial carcinoma has increased with associated rise in variants of urothelial carcinoma and unusual metastatic foci. It is imperative that urologists and pathologists are aware of the unusual variants and unusual metastatic locations to expedite the diagnostic process. Hereby we report an unusual case of secondary involvement of spinal nerve by conventional urothelial carcinoma. Also a second case of rhabdoid variant of urothelial carcinoma showing synchronous involvement of bladder and subcutaneous tissue of upper extremity is presented.

  15. Salivary gland carcinomas of the larynx

    DEFF Research Database (Denmark)

    Nielsen, Troels Krogh; Bjørndal, Kristine; Krogdahl, Annelise;

    2012-01-01

    OBJECTIVE: Salivary gland carcinomas of the larynx are rare. The purpose of this study is to present a national series of laryngeal salivary gland carcinoma patients and to bring a review of recent literature. METHODS: By merging The Danish Cancer Registry, The National Pathology Registry and The...... National Patient Registry all registered patients with laryngeal salivary carcinomas diagnosed from 1990 to 2007 were identified. The histological slides were reviewed and data concerning age, sex, symptoms, topography, histology, treatment and outcome were registered. Based on a supplemented PubMed search...... a review of literature from 1991 to 2010 was performed. RESULTS: Six Danish patients with a malignant salivary gland tumor in the larynx were identified resulting in an incidence of 0.001/100,000 inhabitants/year. Four had adenoid cystic carcinoma and two a mucoepidermoid carcinoma. All patients...

  16. OVARIAN METASTASIS IN PATIENT WITH ENDOMETRIAL CARCINOMA

    Institute of Scientific and Technical Information of China (English)

    ZHOU Feng-zhi; CHEN Yi-nan; ZHANG Guo-nan

    2005-01-01

    Objective: To study the clinical pathological characteristics of ovarian metastasis of endometrial carcinoma and the factors affecting prognosis. Methods: Retrospective analysis was made to the clinical pathological outcome of endometrial carcinoma patients receiving surgical treatment in our hospital from January 1990 to December 2002. Results:Among the 191 cases of endometrial carcinoma patients, 17 cases (8.9%) had ovarian metastasis and young patients were more likely to have ovarian metastasis. The multiple factor analysis showed that the independent risk factors of ovarian metastasis in endometrial carcinoma included the depth of myometrial invasion, lymph node metastasis and pathological types. Conclusion: Ovarian metastasis in patients with endometrial carcinoma is associated with poor prognosis, the depth of myometrial invasion, lymph node metastasis and histologic types are independent risk factors affecting the prognosis. For young patients at early stage of the disease, it should be prudent as to whether to retain the ovary.

  17. Choroid plexus carcinoma in an adult

    Directory of Open Access Journals (Sweden)

    Sanjeev Kishore

    2012-01-01

    Full Text Available Choroid plexus carcinoma is a very rare tumor in adults. Here we report a rare case of choroid plexus carcinoma in an adult patient. A 24-year-old male presented with a right temporal intraventricular tumor with a cystic component also extending up to the cortex. Histological examination revealed complex papillary structures and glandular spaces showing stratification and multilayering of cells with nuclear crowding and numerous mitotic figures and large areas of necrosis. The patient went through a complete search for a possible primary keeping in mind the differential diagnosis of metastatic carcinoma that is more common in adults but there was no evidence of any other tumor. Finally a diagnosis of choroid plexus carcinoma was rendered. Immunohistochemical analysis for p53 protein showed positivity. Choroid plexus carcinoma is exceptionally rare in adults but cases do occur.

  18. [Heterotopic cloacogenic carcinoma of the lower lip].

    Science.gov (United States)

    Vulcan, P; Dumitriu, E; Grigore, M

    1994-01-01

    Cloacogenic carcinoma is a tumour which develops from cylindric epithelial cells at the anorectal junction. Besides this usual localization, other sites have been described including the vagina, urethra, sigmoid colon, vulva and perianal skin. We observed a labial localization in a 50-year-old woman. A 15 mm tumorous formation developed rapidly after initial excision without skin or mucosal changes. The clinical diagnosis was epidermoid carcinoma but histological examination revealed an aspect comparable to cloacogenic carcinoma with nodules of basaloid tumour cells showing atypical mitosis within the nodules and the uniformly eosinophilic masses. We considered that this particular histological aspect eliminated the diagnosis of basocellular or epidermoid carcinoma and suggest that the carcinoma developed from embryon reliquats of cloacoanal transition cells in a heterotopic localization. PMID:7979028

  19. Adrenocortical carcinoma in preoperative diagnostic

    International Nuclear Information System (INIS)

    Decisions concerning surgical treatment of patients with adrenocortical tumor without hormonal hyperactivity are based on tumor size exceeding 3-6 cm and morphological features of malignancy. The aim of the study was to analyze results of diagnostic imaging in patients with adrenocortical carcinoma (ACC). Results of diagnostic imaging of 8 patients in whom postoperative pathological examination revealed ACC were analyzed. There were 3 women and 5 men in the analyzed group, with an age range of 32 to 75 years. Imaging was based on US and CT examination supported by MRI in 2 patients. The obtained results were compared with a group of 10 patients with adrenocortical adenoma (ACA). Results are presented as median values and 95% CI. CT results of patients with ACC showed local spread into surrounding fat tissue in 87.5%, adjacent organ invasion in 75%, local lymph node enlargement in 75%, irregular tumor margins in 88%, and heterogeneous structure of all tumors. In patients with ACA, tumor heterogeneity was observed in 40% and local lymph node enlargement in 10%. ACC tumors were significantly larger than ACA ones [77 (66-97) vs. 31 (24-48) mm, respectively, p=0.0002] and more dense [60 (34-85) vs. 16 (10-26) HU, respectively, p=0.0007]. In arterial phase, enhancement of ACC tumors tended to be stronger compared with ACA [81 (29-162) vs. 55 (33-76), p=0.09]. On the basis of CT results, 1 patient was classified as stage II according to Mac Farlane, 6 as stage III, and 1 as stage IV. Intraoperative examination down-staged 2 patients from stage III to stage II. Computed tomography is a method that allows distinguishing adrenocortical adenoma from carcinoma as well as to determine the stage of adrenocortical carcinoma. (author)

  20. Clinical review of mucoepidermoid carcinomas

    International Nuclear Information System (INIS)

    Mucoepidermoid carcinoma is a rare head and neck cancer tumor, composed of both mucous and epidermoid cells. We retrospectively reviewed the case of 36 such patients hospitalized in the last 24 years (between 1978 and 2002) at Kurume University Hospital, focusing on origin, treatment, and treatment outcome. In this study, 33 patients undergoing currative treatment were studied in detail. Tumors originated in major salivary glands in 24 and in the oral cavity, paranasal cavity, and oropharynx in 3 each. Salivary gland carcinomas were graded, clinically and histopathologically based on the criteria of Goode et al. as follows: low (n=3), intermediate (n=3), and high (n=18). All patients underwent radical surgery. Lymph node metastasis was detected in 9, distant metastasis in 6 (lung: 4; liver: 1; bone: 1), and local recurrence in 5 patients. Lymph node recurrence was detected in 3. Survival was calculated with Kaplan-Meier's methods. Five-year overall survival was 64%, i.e., 56% in salivary gland malignancy, 67% in oral cavity malignancy, 100% in paranasal cavity malignancy and 100% in oropharyax malignancy. Five-year survival was 76% in T2, 75% in T3, 51% in T4. Five-year survival in N0 was 80% and 22% in N+ cases, with a statistically significant difference (p<0.05). Five-year survival was 71% in stage I, 83% in stage II, and 54% in stage IV. Five-year survival in low and intermediate grade was 100%, whereas that in high grade was 43%. The 21 patients undergoing modified neck dissection has a 5-year survival of 52%. In 20 patients undergoing postoperative radiotherapy, 4 died of local recurrence. In 31 patients not undergoing chemotherapy, 6 died of distant metastasis. These results emphasize the necessity of radiotherapy and chemotherapy after surgical treatment for head and neck mucoepidermoid carcinoma. (author)

  1. Endometrial carcinoma in elderly women.

    Science.gov (United States)

    Hoffman, K; Nekhlyudov, L; Deligdisch, L

    1995-08-01

    Endometrial carcinoma remains the most common invasive gynecologic malignancy. Increased longevity is associated with an increased incidence of endometrial carcinoma (EC) in elderly women. While recent studies have looked at aging and its relation to ovarian, breast, and cervical cancer, few have focused on EC in the growing elderly population. This study analyzed 35 histologic specimens of EC in women 75-92 years of age. Findings revealed that only 23% of the tumors were Stage I, G1. The majority (77%) were deeply invasive or of advanced stage (IC-IV). These were G2, G3, or "virulent" types of nonendometrioid EC (undifferentiated, clear cell, uterine serous papillary, and squamous cell carcinoma). Fifty-seven percent of tumors were endometrioid, of which 9% were mixed, including a rare case of nongestational choriocarcinoma. The nonendometrioid tumors, compared to the endometrioid types, were more often high-stage tumors with vascular invasion. They were also more often associated with atrophic (vs hyperplastic) uninvolved endometrium. Clinical risk factors (nulliparity, obesity, estrogen replacement therapy) were assessed and correlated with the histologic findings. It was shown that tumors in the elderly were less likely to be estrogen-related. It was concluded that EC in this age group is more aggressive, histologically less differentiated, and often nonendometrioid compared with EC in the general population. The increased virulence of EC in the elderly may be related to the tumor's independence from hormonal factors, to the poorly understood but well-known diminished immunologic defense against cancer in general in elderly patients, and/or to the belated diagnosis of the disease in this population. PMID:7622105

  2. Ruptura del projecte parental i disposici?? dels preembrions

    OpenAIRE

    Farn??s Amor??s, Esther

    2010-01-01

    La tesi doctoral "Ruptura del projecte parental i disposici?? dels preembrions" analitza els efectes del consentiment a les t??cniques de reproducci?? assistida prestat en el marc d'un projecte parental. La tesi ofereix una resposta als conflictes que enfronten exesposos o exconvivents en relaci?? al dest?? dels preembrions sobrants d'un cicle de fecundaci?? "in vitro" iniciat durant la relaci??. Aquests conflictes constitueixen un grup de casos al voltant del qual no hi ha solucions legislat...

  3. Clinical Aspects of Hepatocellular Carcinoma

    OpenAIRE

    Verhoef, Cornelis

    2008-01-01

    textabstractHepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third most common cause of cancer mortality1. Despite the high numbers of patients diagnosed worldwide (the estimated number of people is 0.5 million cases per year), HCC continue to pose challenging clinical problems. The assessment of the tumor and treatment options needs a multi-disciplinary approach in which the surgeon plays a central role. The aim of this thesis is to update on the incidence,...

  4. Transhemangioma Ablation of Hepatocellular Carcinoma

    International Nuclear Information System (INIS)

    Radiofrequency ablation (RFA) is a well-established treatment modality in the treatment of early hepatocellular carcinoma (HCC) [1]. Safe trajectory of the RFA probe is crucial in decreasing collateral tissue damage and unwarranted probe transgression. As a percutaneous technique, however, the trajectory of the needle is sometimes constrained by the available imaging plane. The presence of a hemangioma beside an HCC is uncommon but poses the question of safety related to probe transgression. We hereby describe a case of transhemangioma ablation of a dome HCC.

  5. Clear Cell Basal Cell Carcinoma

    OpenAIRE

    Bo Wang; Tracey Harbert; Jennifer Olivella; Daniel Olson; Sarma, Deba P; Stephanie Ortman

    2011-01-01

    Introduction. Clear cell basal cell carcinoma (BCC) is an uncommon and unusual variant of BCC, which is characterized by a variable component of clear cells. The pathogenesis of this histological variant and its clinical significance has not been clarified. Differentiation of this uncommon variant of BCC from other clear cell tumors is important for the treatment. Case Presentation. A 65-year-old male presented with a 0.9 cm dome-shaped lesion on his upper chest. A shave biopsy revealed a der...

  6. Preoperative hypoxyradiotherapy of colorectal carcinoma

    International Nuclear Information System (INIS)

    Aim: The article focuses on the radioprotective effect of acute hypoxia on healthy tissues during preoperative accelerated hypoxyradiotherapy of colorectal carcinoma performed as locoregional irradiation including the common iliac lymph nodes. Analysis of early and late side effects and complications. Patients and Methods: In this prospective study, early and late complications were assessed in 50 patients as a function of hypoxyradiotherapeutic dose increase. The preliminary treatment results of this radiotherapeutic modification were evaluated after a median follow-up of 48 months using Kaplan-Meier analysis. Between April 1991 and February 1997, 50 patients (36 men and 14 women) with colorectal carcinoma were treated preoperatively with locoregional accelerated hypofractionated hypoxyradiotherapy. The extent of disease was classified according to Dukes' criteria (A: four patients, B: 28 patients, C: 18 patients). We used a 20-MeV linear accelerator with two parallel opposed fields. Hypoxyradiotherapy was performed extending from the perineum to the L4 region. Acute hypoxia was induced during irradiation by ventilation of a hypoxic gas mixture containing 7.8-8.0% oxygen. Total doses of 24 Gy/8 days, 28 Gy/9 days, and 32 Gy/10 days were applied in five, 20, and 25 patients, respectively. Low anterior resection or abdominoperineal amputation of the rectum was performed the day after completion of preoperative hypoxyradiotherapy. The early reactions after irradiation were evaluated according to the Common Toxicity Criteria of the National Cancer Institute (CTC-NCI). Results: Early postirradiation proctitis was documented in three and early radiation-induced cystitis in two patients only. Neither early nor late radiation-associated complications were observed in any of the three hypoxyradiotherapy schedules during the follow-uper period of 6-105 months. Based on Kaplan-Meier analysis (median 48 months), a 5-year overall survival rate of 61.5% and a local relapse

  7. Prostatic carcinoma in two cats

    International Nuclear Information System (INIS)

    Clinical, radiological and pathological features of two cats with prostatic carcinoma are reported. In both cats the presenting history included signs of lower urinary tract disease with haematuria and dysuria. Prostatomegaly was visible radiographically in one cat; an irregular intraprostatic urethra was seen on retrograde contrast urethrography in both cats. In one of the cats, neoplasia was suspected on the basis of a transurethral catheter biopsy. Following a poor response to palliative treatment in both cases, euthanasia was performed with histological confirmation of the diagnosis

  8. Transhemangioma Ablation of Hepatocellular Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Pua, Uei, E-mail: druei@yahoo.com [Tan Tock Seng Hospital, Department of Diagnostic Radiology (Singapore)

    2012-12-15

    Radiofrequency ablation (RFA) is a well-established treatment modality in the treatment of early hepatocellular carcinoma (HCC) [1]. Safe trajectory of the RFA probe is crucial in decreasing collateral tissue damage and unwarranted probe transgression. As a percutaneous technique, however, the trajectory of the needle is sometimes constrained by the available imaging plane. The presence of a hemangioma beside an HCC is uncommon but poses the question of safety related to probe transgression. We hereby describe a case of transhemangioma ablation of a dome HCC.

  9. Carcinoma of the Ectopic Breast

    Directory of Open Access Journals (Sweden)

    AMM Shariful Alam

    2013-01-01

    Full Text Available A 43-year-old woman presented with bilateral ectopic breasts in both the axillae in Chittagong Medical College Hospital in July 1996. She was diagnosed having carcinoma in the left ectopic breast. She was successfully treated with local surgical excision and regional lymph node dissection, adjuvant chemotherapy, loco-regional radiotherapy and hormone therapy. The patient continued tamoxifen for 5 years. Till last follow-up in December 2011, the patient was asymptomatic without any evidence of residual disease or local recurrence and evidence of metastases.

  10. Sociedad abierta del conocimiento

    OpenAIRE

    Echeverría, Javier

    2007-01-01

    En las sociedades del conocimiento hay dos modelos opuestos de gestión: conocimiento libre y conocimiento propietario. Ambos generan desarrollos tecnológicos e innovaciones, pero el primero favorece la emergencia de sociedades abiertas del conocimiento. Aplicando las propuestas de von Hippel, este artículo muestra que la contraposición entre ambos modelos no sólo afecta a la producción y distribución del conocimiento, también a su almacenamiento y uso. Los usuarios son la principal fuente de ...

  11. Secretos del test extraterrestre

    OpenAIRE

    Hybris, Profesor

    2016-01-01

    Por el parasicólogo y astrólogo Profesor Hybris La prensa mundial ha revelado recientemente los detalles del extraño caso de Asdrúbal Carrasquilla, el camionero chileno que desapareciera misteriosamente en su país, ante el asombro de varios automovilistas que lo vieron desvanecerse en el aire, junto con su camión, en la muy transitada vía entre Las Fraguas y San Venancio, en la provincia chilena de Valverde. El hecho ocurrió a las 16.55 del 15 de diciembre de 1981. A las 16.58 del mismo día, ...

  12. La muerte del mito

    OpenAIRE

    Sánchez-Biosca, Vicente

    1990-01-01

    Habría de ser de nuevo John Ford quien sentenciará la defunción del western en cuanto mito, su imposibilidad de construirse en el vacío de la historia. Y habría de ser en uno de los más lúcidos films de la historia del cine: The Man who shot Liberty Valance (El hombre que mató a Liberty Valance, 1962). Todo en este film posee un reverso: un viaje en ferrocarril abre paso al pueblecito de Shinbone. Pero, en el interior del relato, otro emprendido por el antes pionero y ho...

  13. La escritura del mundo

    OpenAIRE

    Martínez García-Posada, Ángel

    2010-01-01

    El mapa de un arquitecto es un paisaje alternativo, una representación intencionada del medio que se aleja del documento impuesto y apunta la posibilidad de transformarlo, así comienza el proyecto; el sentido inverso, llevar al territorio los signos del plano, remite a la esencia de la arquitectura y su capacidad de alterar el mundo. Nuestras representaciones describen una realidad y a su vez son otra distinta, entre ambos campos se produce un flujo que los liga y los condiciona. La cartograf...

  14. LA ESCRITURA DEL MUNDO

    OpenAIRE

    Ángel Martínez García-Posada

    2010-01-01

    RESUMEN El mapa de un arquitecto es un paisaje alternativo, una representación intencionada del medio que se aleja del documento impuesto y apunta la posibilidad de transformarlo, así comienza el proyecto; el sentido inverso, llevar al territorio los signos del plano, remite a la esencia de la arquitectura y su capacidad de alterar el mundo. Nuestras representaciones describen una realidad y a su vez son otra distinta, entre ambos campos se produce un flujo que los liga y los condiciona. La c...

  15. Squamous cell carcinoma arising in an odontogenic cyst

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jae Jung; Hwang, Eui Hwan; Lee, Sang Rae [Kyunghee University College of Medicine, Seoul (Korea, Republic of); Choi, Jeong Hee [Chonnam National University College of Medicine, Kwangju (Korea, Republic of)

    2003-12-15

    Squamous cell carcinoma arising in an odontogenic cyst is uncommon. The diagnosis of carcinoma arising in a cyst requires that there must be an area of microscopic transition from the benign epithelial cyst lining to the invasive squamous cell carcinoma. We report a histopathologically proven case of squamous cell carcinoma arising in a residual mandibular cyst in a 54-year-old woman.

  16. Carcinoma de células de Merkel: A propósito de un caso Merkel cell carcinoma: On one case

    Directory of Open Access Journals (Sweden)

    M. Cires

    2008-08-01

    Full Text Available Presentamos el caso de una mujer de 86 años que fue remitida a consulta de Cirugía General por presentar tumoración asintomática en la cara posterior del muslo izquierdo cuyo tamaño había aumentado durante los 2 últimos meses. Se apreciaba en la exploración física una tumoración indolora, excrecente, indurada, móvil y bien delimitada, de 5 cm de diámetro, de coloración rojiza y superficie rugosa. Se realizó la extirpación tumoral con márgenes amplios, con resultado histopatológico de carcinoma neuroendocrino primario cutáneo o carcinoma de células de Merkel. Se realizó tomografía computarizada, observando adenopatías tumorales en los espacios paraaórtico, cadenas ilíacas y femorales izquierdas, así como edema en la extremidad inferior izquierda. Se remitió a la paciente al servicio de Oncología para continuar tratamiento pertinente, sin presentar evolución satisfactoria y con progresivo deterioro del estado general, falleciendo dentro del primer año tras el diagnóstico.We present the case of an 86 year old woman who was sent for consultation at General Surgery due to asymptomatic tumouration on the back face of the left thigh whose size had increased during the 2 previous months. Physical exploration revealed tumouration that was painless, excrescent, indurated, mobile and well delimited, with a diameter of 5 cm, a reddish colour and a rough surface. Tumoural extirpation was carried out with broad margins, with a hystopathological result of primary cutaneous neuro-endocrynal carcinoma or Merkel cell carcinoma. Computerised tomography was carried out, observing tumoural adenopathies in the para-aortic spaces, iliac chains and left femorals, as well as edema in the lower left extremity. The patient was sent to the Oncology service for treatment, without presenting a satisfactory evolution and with a progressive deterioration of her general state, dying within the first year after diagnosis.

  17. Estudio clínico y genético en carcinoma basocelular esporádico y asociado a Síndrome de Gorlin

    OpenAIRE

    Palacios Álvarez, Irene

    2016-01-01

    [ES] El carcinoma basocelular (CBC) es el tumor más común en la población caucásica y constituye aproximadamente el 80% de los cánceres cutáneos no melanoma. Existen dos formas fundamentales de presentación: esporádica y asociada a genodermatosis, destacando el siíndrome de gorlin en este último grupo. En la patogenia molecular del carcinoma basocelular destacan las mutaciones en el gen PTCH1, que se encuentra involucrado en la vía de señalización sonic hedhehog. El objetivo de esta ...

  18. Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma.

    Science.gov (United States)

    Zhu, Jian; Qin, Chao; Wang, Meilin; Yan, Fu; Ju, Xiaobing; Meng, Xiaoxin; Ding, Qi; Li, Pu; Yang, Jian; Cao, Qiang; Zhang, Zhengdong; Yin, Changjun

    2010-09-01

    The FAS/FAS ligand (FASL) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis. However, the effects of functional promoter polymorphisms of the CASP8, FAS, and FASL genes on risk of renal cell carcinoma (RCC) are unknown. In this study, we genotyped CASP8 -652 6N ins/del, FAS -1377 G > A, FAS -670 A > G, and FASL -844 C > T polymorphisms in a hospital-based case-control study of 353 patients diagnosed with RCC and 365 cancer-free controls in a Chinese population. Compared with CASP8 -652 ins/ins genotype, the del/del genotype had a significantly decreased RCC risk [adjusted odds ratio (OR) = 0.36, 95% confidence interval (CI) = 0.16-0.84]. For FAS -1377 G > A polymorphism, a significantly increased risk of RCC was found for AA (adjusted OR = 1.65, 95% CI = 1.03-2.64) and GA (adjusted OR = 1.41, 95% CI = 1.02-1.94) genotypes compared with GG genotype. When we combined these two polymorphisms together, we found that individuals carrying CASP8 -652 6N ins/del and FAS -1377 GG genotypes or CASP8 -652 6N del/del and FAS -1377 GG genotypes were associated with a statistically significantly decreased risk of RCC (adjusted OR = 0.46, 95% CI = 0.24-0.88 and OR = 0.12, 95% CI = 0.02-0.58, respectively) compared with individuals carrying CASP8 -652 6N ins/ins and FAS -1377 AA genotypes. These results suggest that the CASP8 -652 6N ins/del and FAS -1377 G > A polymorphisms are involved in the susceptibility to developing RCC in Chinese populations. PMID:20572163

  19. Actividad del virus del oeste del Nilo y otros flavivirus en cinco departamentos del Caribe colombiano

    Directory of Open Access Journals (Sweden)

    Jaime Álvarez

    2010-04-01

    Full Text Available El virus del oeste del Nilo (VON y el virus de la encefalitis de San Luis (VESL pertenece a la familia Flaviviridae, género Flavivirus y hacen parte del serocomplejo de la encefalitis japonesa (1. Estos virus se encuentran distribuidos en Estados Unidos, centro América y suramerica (2. Son mantenidos en la naturaleza en un ciclo enzoótico ave-mosquito-ave. Humanos, équidos y otros vertebrados se infectan por la picadura de mosquitos del genero Culex principalmente (1,2. En humanos se han identificado y descrito nuevos modos de transmisión de VON incluyendo infección a través de productos sanguíneos contaminados (3, transplante de órganos (4, transmisión a través de la leche materna (5, transmisión intrauterina (6, y exposición ocupacional (7.

  20. External auditory canal carcinoma treatment

    International Nuclear Information System (INIS)

    External auditory canal (EAC) carcinomas are relatively rare conditions lack on established treatment strategy. We analyzed a treatment modalities and outcome in 32 cases of EAC squamous cell carcinoma treated between 1980 and 2008. Subjects-17 men and 15 women ranging from 33 to 92 years old (average: 66) were divided by Arriaga's tumor staging into 12 T1, 5 T2, 6 T3, and 9 T4. Survival was calculated by the Kaplan-Meier method. Disease-specific 5-year survival was 100% for T1, T2, 44% for T3, and 33% for T4. In contrast to 100% 5-year survival for T1+T2 cancer, the 5-year survival for T3+T4 cancer was 37% with high recurrence due to positive surgical margins. The first 22 years of the 29 years surveyed, we performed surgery mainly, and irradiation or chemotherapy was selected for early disease or cases with positive surgical margins as postoperative therapy. During the 22-years, 5-year survival with T3+T4 cancer was 20%. After we started superselective intra-arterial (IA) rapid infusion chemotherapy combined with radiotherapy in 2003, we achieved negative surgical margins for advanced disease, and 5-year survival for T3+T4 cancer rise to 80%. (author)

  1. HPV Carcinomas in Immunocompromised Patients

    Directory of Open Access Journals (Sweden)

    Nicole M. Reusser

    2015-01-01

    Full Text Available Human papillomavirus (HPV infection is the most common sexually transmitted disease worldwide and can result in pre-malignancies or overt malignancies of the skin and mucosal surfaces. HPV-related illnesses are an important personal and public health problem causing physical, mental, sexual and financial detriments. Moreover, this set of malignancies severely affects the immunosuppressed population, particularly HIV-positive patients and organ-transplant recipients. There is growing incidence of HPV-associated anogenital malignancies as well as a decrease in the average age of affected patients, likely related to the rising number of high-risk individuals. Squamous cell carcinoma is the most common type of HPV-related malignancy. Current treatment options for HPV infection and subsequent disease manifestations include imiquimod, retinoids, intralesional bleomycin, and cidofovir; however, primary prevention with HPV vaccination remains the most effective strategy. This review will discuss anogenital lesions in immunocompromised patients, cutaneous warts at nongenital sites, the association of HPV with skin cancer in immunocompromised patients, warts and carcinomas in organ-transplant patients, HIV-positive patients with HPV infections, and the management of cutaneous disease in the immunocompromised patient.

  2. Surgical Treatment for Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Ahmad A Madkhali

    2015-01-01

    Full Text Available Hepatocellular carcinoma (HCC is an epithelial tumor derived from hepatocytes; it accounts for 80% of all primary liver cancers and ranks globally as the fourth leading cause of cancer-related deaths. HCC treatment is a multidisciplinary and a multimodal task, with surgery in the form of liver resection and liver transplantation (LT representing the only potentially curative modality. However, there are variable opinions and discussions about applying these surgical options and using other supporting treatments. This article is a narrative review that includes articles published from 1984 to 2013 located by searching scientific databases such as PubMed, SCOPUS, and Elsevier, with the main keyword of hepatocellular carcinoma in addition to other keywords such as liver transplantation, liver resection, transarterial chemoembolization, portal vein embolization, bridging therapy, and downstaging. In this review, we focus mainly on the surgical treatment options offered for HCC, in order to illustrate the current relevant data available in the literature to help in applying these surgical options and to use other supporting treatment modalities when appropriate.

  3. Epigenetic mechanisms in penile carcinoma

    DEFF Research Database (Denmark)

    Kuasne, Hellen; Marchi, Fabio Albuquerque; Rogatto, Silvia Regina;

    2013-01-01

    Penile carcinoma (PeCa) represents an important public health problem in poor and developing countries. Despite its unpredictable behavior and aggressive treatment, there have only been a few reports regarding its molecular data, especially epigenetic mechanisms. The functional diversity in diffe......Penile carcinoma (PeCa) represents an important public health problem in poor and developing countries. Despite its unpredictable behavior and aggressive treatment, there have only been a few reports regarding its molecular data, especially epigenetic mechanisms. The functional diversity...... in different cell types is acquired by chromatin modifications, which are established by epigenetic regulatory mechanisms involving DNA methylation, histone acetylation, and miRNAs. Recent evidence indicates that the dysregulation in these processes can result in the development of several diseases, including...... cancer. Epigenetic alterations, such as the methylation of CpGs islands, may reveal candidates for the development of specific markers for cancer detection, diagnosis and prognosis. There are a few reports on the epigenetic alterations in PeCa, and most of these studies have only focused on alterations...

  4. Carcinoma breast: a histopathological audit

    International Nuclear Information System (INIS)

    Objective: To compare audited results with original reports in cases of breast carcinoma, as a part of quality assurance programme. Design: A descriptive study. Place and Duration of Study: January 2001 to December 2001 at the Armed Forces Institute of Pathology (AGIP), Rawalpindi, Pakistan. Materials and Methods: Slides and original reports of 191 cases of breast carcinoma diagnosed by different consultants in the department were retrieved from the case files. The cases were re-examined for histological type, nuclear grade, tumor grade, Iymphovascular invasion and tumor necrosis without knowledge of the previous report. The new independent observations were recorded and differences from original reports were analysed. Chi-square test was used for statistical analysis. Results: There was no discrepancy about malignant nature of all the 191 lesions. However, 39 cases (20.4%) showed some differences of grade, Iymphovascular invasion and necrosis, from their original reports. Omission of most of the parameters (n=45) was due to lack of tabulated reporting. The differences of results of Iymphovascular invasion and necrosis were not statistically significant (p-values = 0.90 each), but differences of nuclear and tumor grade were statistically significant (p-value <0.001 and <0.01). Conclusion: There was no discrepancy in the reports such as histological types or the presence of tumors. Tabulated form of reporting has less chance of omission of important parameters. (author)

  5. Pulmonary mass with renal carcinoma

    International Nuclear Information System (INIS)

    The paper analyzes the case of a 73 year-old patient, masculine sex, obese, with syndrome of obstructive apnoea of the dream, reason why he uses nasal CPAP for 2 at 3 hours in the night for 2 years. It was intervened by renal carcinoma of clear cells at the end of the year 2002. The Rx of thorax preoperative had been informed as normal, but in an abdominal preoperative tomography, the presence of a mass was suggested in the base right lung thorax, reason why Tac is practiced, which demonstrates an irregular nodular image clearly, stuck to the pleura that that suggests unique metastasis of the renal carcinoma. Masses neither mediastinal adenopaties were not evidenced. In the post-operative of their nefrectomy the patient presented dehiscence of the sutures and evisceration, reason why he was re-intervened with primary closing and managed with antibiotics, achieving appropriate scaring. It was programmed for resection of the pulmonary mass. Their evolution and discusses of the case are studied

  6. MR staging of endometrial carcinoma

    International Nuclear Information System (INIS)

    Biopsy is the technique of choice for the definitive diagnosis of endometrial carcinoma. Since lymphatic tumor spread has been demonstrated to depend on the degree of myometrial involvement, the definition of the latter with imaging techniques may significantly affect both pfognosis and therapy. We investigated, by means of MR imaging at 0.5 T, 14 patients with endometrial carcinoma, to assess both tumor stage and myometrial involvement. FIGO staging system was employed, and M parameter evaluated (M0= no myometrial involvement; M1involvement confined to the inner third; M2= Involvement confined to the middle third; M3= involvement of the whole myometrium). Another parameter was the characteristic high signal of the tumor on PD and T2W images. The patients were then operated and MR information was correlated with surgical findings. Overall diagnostic accuracy of MR imaging was 85.7% in tumor staging, and 92.2% in defining M parameter. Tumor spread into adnexa and into cervical canal was poorly demonstrated by MR imaging

  7. Carcinoma of the anal canal

    International Nuclear Information System (INIS)

    There are many unresolved issues in the management of epidermoid anal canal cancer, although substantial progress has been made in gaining acceptance of techniques that preserve anal function. Resolution of the most basic questions would require formal comparisons of radical surgery, radiation therapy alone, and combined modality therapy. However, patients are unlikely to participate in studies in which one or more options would offer a chance to avoid a colostomy. Informal comparisons of published series suggest that modern radiation therapy and combined modality therapy give survival rates similar to those reported following radical surgery. Other questions being addressed include identification of optimal radiation techniques, detailed exploration of the mechanisms, efficacy, and toxicity of drug and radiation combinations, and identification of effective systemic chemotherapy. All studies are made difficult by the relative rarity of this tumor. Even without formal clinical trials, however, the series reported the use of either radiation therapy alone or combined modality therapy as the initial treatment for epidermoid anal canal carcinoma, thereby preserving anal function whenever possible and reserving radical surgery for the patient with residual carcinoma

  8. Evaluación del efecto de células madre mesenquimales derivadas de tejido adiposo y de medios condicionados en la recuperación motora de ratas con lesión medular / Effect of mesenchymals stem cells derived from human adipose tissue and conditioned medium in motor recovery of rats with spinal cord injury

    OpenAIRE

    Núñez Ríos, Diana Leandra

    2010-01-01

    La médula espinal al permitir la transmisión de impulsos nerviosos, favorece el movimiento en organismos cordados, por lo que un evento traumático se traduce en una disfunción neuronal con pérdida de las facultades motrices. Infortunadamente el porcentaje de regeneración espontánea es de tan solo un 1%, causando una discapacidad severa en las personas afectadas y aumentando los costos en el sistema de salud por el pago de incapacidades y manejo de la enfermedad. Las células madre mesenquimale...

  9. Profundidad tumoral y variables histopatológicas en el carcinoma epidermoide lingual: Estudio retrospectivo sobre 60 pacientes Tumoral thickness and histopathological parameters in the squamous cell carcinoma of tongue: A retrospective evaluation over 60 patients

    Directory of Open Access Journals (Sweden)

    JD Sánchez López

    2005-10-01

    Full Text Available I.- Introducción: La profundidad tumoral representa uno de los principales factores pronósticos del carcinoma epidermoide lingual. II.-Objetivos: Verificar si el espesor máximo tumoral se correlaciona con parámetros histopatológicos agresivos. III.-Material y Métodos: -Diseño: Estudio retrospectivo de base hospitalaria (Enero-1990 a Julio-1997 constituido por 60 pacientes afectos de carcinoma escamoso lingual. -Variables: Filiación del paciente, parámetros histopatológicos y profundidad tumoral. -Procedimientos de laboratorio. -Métodos estadísticos: Estadística descriptiva e inferencial (Método Bonferroni, C- Dunnet, Chi-cuadrado y test de Anova. IV.-Resultados: Asociación estadísticamente significativa entre Indice mitótico y profundidad tumoral (14,84;pI.-Introduction: The tumoral thickness represents one of the most ominous prognostic factors of the squamous cell carcinoma of tongue. II.-Objectives: To verify if the tumoral thickness is relationated with others aggressive histopathologic parameters. III.-Material and Methods: -Design: A hospital population retrospective study (January-1990 to July-1997 of 60 patients affected of carcinoma of tongue. -Variables: Data patients, histopathological parameters and tumoral thickness. -Laboratory procedures. -Stadistic methods: Descriptive and Inferential stadistical: Bonferroni method, C-Dunnet, Chi-square, Anova test… IV.-Results: There is a statistic association between mitotic Index and tumoral thickness (14,84; p<0,001. V.-Conclusions: Depth of invasion and mitotic Index are actually associated prognostic factors in the carcinoma epidermoid of tongue.

  10. El vicio del amor

    OpenAIRE

    Zaietz, Patricia

    2007-01-01

    “Si alguien entre nosotros no conoce el arte de amar, que lea este poema y, adoctrinado por su lectura, ame”. Con generoso didactismo, comienza Ovidio, poeta romano (43 a.C.-17 d.C), su libro Arte de Amar, texto clásico bien conocido por el clérigo Guillaume de Lorris al momento de escribir la primera parte del Roman de la Rose. (Párrafo extraído del texto a modo de resumen)

  11. Il problema del litio.

    Science.gov (United States)

    D'Antona, F.

    1995-03-01

    Contents: 1. Introduzione. 2. La nucleosintesi del Big Bang. 3. Il litio nelle stelle di popolazione II. 4. I modelli stellari standard. 5. Il litio negli ammassi aperti. 6. Meccanismi di distruzione "non standard". 7. I modelli non-standard applicati alla popolazione II. 8. L'evoluzione Galattica del litio. 9. Quali stelle producono litio? 10. Il litio come elemento chiave per dare un nome agli oggetti stellari più minuscoli. 11. Conclusioni.

  12. ERG gene rearrangements are common in prostatic small cell carcinomas

    OpenAIRE

    Lotan, Tamara L.; Gupta, Nilesh S; Wang, Wenle; Toubaji, Antoun; Haffner, Michael C; Chaux, Alcides; Hicks, Jessica L.; Meeker, Alan K.; Bieberich, Charles J.; De Marzo, Angelo M.; Epstein, Jonathan I; Netto, George J.

    2011-01-01

    Small cell carcinoma of the prostate is a rare subtype with an aggressive clinical course. Despite the frequent occurrence of ERG gene rearrangements in acinar carcinoma, the incidence of these rearrangements in prostatic small cell carcinoma is unclear. In addition, molecular markers to distinguish prostatic small cell carcinomas from lung and bladder small cell carcinomas may be clinically useful. We examined the occurrence of ERG gene rearrangements by fluorescence in situ hybridization in...

  13. Flowcharts for the management of biliary tract and ampullary carcinomas

    OpenAIRE

    Miyakawa, Shuichi; Ishihara, Shin; Takada, Tadahiro; Miyazaki, Masaru; TSUKADA, KAZUHIRO; Nagino, Masato; Kondo, Satoshi; Furuse, Junji; Saito, Hiroya; Tsuyuguchi, Toshio; Kimura, Fumio; Yoshitomi, Hideyuki; Nozawa, Satoshi; Yoshida, Masahiro; Wada, Keita

    2008-01-01

    No strategies for the diagnosis and treatment of biliary tract carcinoma have been clearly described. We developed flowcharts for the diagnosis and treatment of biliary tract carcinoma on the basis of the best clinical evidence. Risk factors for bile duct carcinoma are a dilated type of pancreaticobiliary maljunction (PBM) and primary sclerosing cholangitis. A nondilated type of PBM is a risk factor for gallbladder carcinoma. Symptoms that may indicate biliary tract carcinoma are jaundice and...

  14. Basal cell carcinoma in oculo-cutaneous albinism

    OpenAIRE

    Ajay Kumar; Ashish Chauhan; Subhash Kashyap

    2016-01-01

    The basal cell carcinoma is the most common skin tumour especially affecting the white individuals worldwide. The exact incidence of basal cell carcinoma is not known from India but non melanoma skin cancers comprises about 1-2% of cutaneous tumour in India. The most common skin tumour is squamous cell carcinoma in albinism and the incidence of basal cell carcinoma is less. Hereby, we report a peculiar case of basal cell carcinoma in albinism to highlights the importance of early recognition ...

  15. Radiation therapy for advanced laryngeal carcinoma

    International Nuclear Information System (INIS)

    From 1967 through 1985, 92 patients with T3 and T4 laryngeal carcinoma were treated with radiation at Osaka University Hospital. Of 92 patients, patients with 14 T3 and 29 T4 carcinoma were treated with a total dose of 60 Gy or more, and those with 14 T3 and 21 T4 carcinoma were treated with a total dose of 40 to 58 Gy and followed by total laryngectomy. Other 14 patients were palliatively treated with a total dose less than 60 Gy without surgery. The 5-year local control rates for T3 and T4 carcinoma treated with radical radiation were 48% and 24%, respectively. The 5-year cause-specific survival rates for T3 carcinoma treated with radical and preoperative radiotherapy were 48% and 71%, and corresponding figures for T4 carcinoma were 52% and 43%. There were no statistically significant differences between cause-specific survival rates of radical and preoperative groups. The 5-year cause-specific survival rates for T3N0 and T4N0 cases treated with radical radiation were 83% and 56%, and corresponding figures for T3N+ and T4N+ cases were 13% and 45%. Voice preservation rates of T3 and T4 patients treated with radical radiation were about 1/2 and 1/4, respectively. Considering the QOL of patients, radiotherapy for advanced carcinoma of larynx should be considered as a primary treatment especially for N0 cases. (author)

  16. BRAIN METASTASES FROM CARCINOMA OF UTERINE CERVIX

    Institute of Scientific and Technical Information of China (English)

    张国楠; 徐世强; 石宇; 樊英; 吴艳丽; 殷红; 余健; 陈毅男

    2002-01-01

    Objective: To study the mechanism, clinical characteristics, therapy regimens, and survival of cervical carcinoma metastases to the brain. Methods: We retrospectively analyzed 11 patients with brain metastases from cervical carcinoma. Results: Two cases were at stage lb, two at IIa, and seven at IIIb, respectively. Histologically, they were squamous cell carcinoma (6 cases), adeno-squamous carcinoma (2 cases), small cell carcinoma (2 cases), or adenocarcinoma (1 cases), poorly differentiated. Eight were accompanied with lung, liver, and bone metastases disease and three had no any other systemic metastases at the time of the brain metastases diagnosis. Two had controlled, and other nine were uncontrolled or progressive primary disease. The median interval from the diagnosis of the primary carcinoma to the detection of brain lesion was 14.6 months. Headache was the most common symptom of brain metastases. Eight of 11 patients developed multiple lesions and other 3 cases had a solitary lesion in brain. The patients were treated by combination of surgery and whole brain radiation therapy (WBRT) (3 cases), stereotactic radiosurgery (SRS) (3 cases), or WBRT (5 cases). The patients had a median survival of 6.6 months. Conclusion: Brain metastases are not always a late complication of cervical carcinoma. The development of the metastases is related to pathological type, poorly differentiation, and advanced stage. Surgery and SRS arc the appropriate therapy regimen for these patients.

  17. el Valle del Cauca

    Directory of Open Access Journals (Sweden)

    Carlos Humberto Ortiz

    2007-01-01

    Full Text Available Este artículo se enfoca en la identi- ficación de aquellos factores estructurales que explican la pérdida de dinamismo económico de largo plazo en Colombia y, en particular, en el Valle del Cauca. Se examina la competitividad del Valle en relación con Colombia y con el resto del mundo. Se cuestiona la insistencia en una estrategia exportadora como dinamizadora del desarrollo económico. Se identifica que una gran parte de la población está excluida de los beneficios del desarrollo económico. Para construir un modelo de desarrollo que incluya a esta población se recomienda recuperar la senda de la industrialización, invertir en el capital humano (educación de alta calidad, salud, salubridad y nutrición, e invertir en infraestructura. La participación del Estado en estas inversiones sociales es necesaria para disminuir la desigualdad y aumentar el crecimiento económico.

  18. pensiones del ISSSTE

    Directory of Open Access Journals (Sweden)

    Alejandro Villagómez Amezcua

    2005-01-01

    Full Text Available El análisis en este estudio ofrece una valoración sobre el problema de viabilidad financiera del programa de pensiones del ISSSTE y la urgente necesidad de modificarlo, no sólo por el costo fiscal que implica, sino porque este costo será creciente. Actualmente las aportaciones no son suficientes para cubrir las pensiones vigentes por lo que se recibe una transferencia de recursos del ramo XIX que en 2001 superó 0.20% del PIB. Utilizando supuestos moderados para el comportamiento futuro de la economía y de este programa, estimamos que de no reformarse el costo fiscal oscilará entre 22 y 39% del PIB. Si se realiza una reforma menor que sólo afecte algunos de los parámetros del esquema actual como contribuciones y edad de retiro, este costo puede reducirse en casi 50%. Sin embargo, no deben descartarse alternativas mixtas que permitan mitigar este costo aún más al tiempo que el programa cumpla con su objetivo final que es el de garantizar pensiones a los trabajadores.

  19. Espectroscopia del Cometa Halley

    Science.gov (United States)

    Naranjo, O.; Fuenmayor, F.; Ferrin, L.; Bulka, P.; Mendoza, C.

    1987-05-01

    Se reportan observaciones espectroscópicas del cometa Halley. Los espectros fueron tomados usando el espectrógrafo del telescopio reflector de 1 metro del Observatorio Nacional de Venezuela. Se utilizó óptica azul, con una red de difracción de 600 lineas/min, obteniéndose una dispersión de 74.2 A/mm y una resolución de 2.5 A, en el rango espectral de 3500 a 6500 A. Seis placas fueron tomadas con emulsión IIa-O y dos con IIa-D. Los tiempos de exposición fueron entre 10 y 150 minutos. El cometa se encontraba entre 0.70 y 1.04 UA del Sol, y entre 1.28 y 0.73 UA de la Tierra. Las emisiones más prominentes en el espectro, son las del CN, C2, y C3. Otras emisiones detectadas corresponden a CH, NH2 y Na. Los espectros muestran un fuerte continuo, indicando un contenido significativo de polvo. Se detectó mayor intensidad del contínuo, en la dirección anti solar, lo cual es evidencia de la cola de polvo.

  20. Carcinoma de células renales: descripción de casos

    Directory of Open Access Journals (Sweden)

    Lindsay Chacón-Garita

    2015-09-01

    Full Text Available Justificación: los carcinomas de células renales son un grupo de neoplasias malignas originadas del epitelio de los túbulos renales. Estas neoplasias representan en promedio un 90% de todas las neoplasias malignas renales en adultos de ambos sexos. El tabaco ha sido descrito en la bibliografía como el principal factor de riesgo; otras variables como el sobrepeso y la obesidad se han ligado a los mecanismos que participan en la inducción de estos tumores malignos. Se ha descrito además, una mayor incidencia en pacientes con hipertensión arterial. El objetivo fue determinar la incidencia, los factores de riesgos asociados y las características clínico-patológicas de los carcinomas de células renales, con base en los resultados de las biopsias del Servicio de Patología del Hospital San Rafael de Alajuela. Métodos: se revisó los expedientes clínicos y las láminas histológicas de cada una de las biopsias diagnosticadas como carcinomas de células renales, en el periodo comprendido entre enero de 2009 y diciembre de 2013, para determinar la incidencia, los factores de riesgo asociados y las características clínico- patológicas. Resultados: en este periodo se diagnosticó un total de 36 carcinomas de células renales, 27 de los cuales se presentaron en pacientes de sexo masculino. La edad promedio de presentación fue de 60,1 años (43 a 79 años. Del total de los casos, 21 presentaron índices de masa corporal por encima de rangos normales, 26 pacientes eran hipertensos y 15 eran tabaquistas. El diagnóstico clínico de estos tumores fue incidental en la mayoría de los casos. El tamaño del tumor fue en promedio de 5,7cm; en el 86,1% de los casos se trató de CCR de tipo células claras; un 58,3% tuvo un grado histológico de Fuhrman II y un 47,2% corresponde a tumores con un estadio temprano (T1. Conclusiones: los carcinomas de células renales afectan predominantemente a los pacientes de sexo masculino, en la sexta década de la