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Sample records for carboxykinase links anaplerosis

  1. Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells

    International Nuclear Information System (INIS)

    Resistance to 5-fluorouracil (5-FU) in patients with colorectal cancer prevents effective treatment and leads to unnecessary and burdensome chemotherapy. Therefore, prediction of 5-FU resistance is imperative. To identify the proteins linked to 5-FU resistance, two-dimensional gel electrophoresis-based proteomics was performed using the human colon cancer cell line SNU-C4R with induced 5-FU resistance. Proteins showing altered expression in SNU-C4R were identified by matrix-associated laser desorption/ionization–time-of-flight analysis, and their roles in susceptibility to 5-FU or radiation were evaluated in various cell lines by transfection of specific siRNA or creation of overexpression constructs. Changes in cellular signaling and expression of mitochondrial apoptotic factors were investigated by Western Blot analysis. A mitochondrial membrane potential probe (JC-1 dye) and a flow cytometry system were employed to determine the mitochondrial membrane potential. Finally, protein levels were determined by Western Blot analysis in tissues from 122 patients with rectal cancer to clarify whether each identified protein is a useful predictor of a chemoradiation response. We identified mitochondrial phosphoenolpyruvate carboxykinase (mPEPCK) as a candidate predictor of 5-FU resistance. PEPCK was downregulated in SNU-C4R compared with its parent cell line SNU-C4. Overexpression of mPEPCK did not significantly alter the susceptibility to either 5-FU or radiation. Suppression of mPEPCK led to a decrease in both the cellular level of phosphoenolpyruvate and the susceptibility to 5-FU and radiation. Furthermore, the cellular levels of phosphoenolpyruvate (an end product of PEPCK and a substrate of pyruvate kinase), phosphorylated AKT, and phosphorylated 4EBP1 were decreased significantly secondary to the mPEPCK suppression in SNU-C4. However, mPEPCK siRNA transfection induced changes in neither the mitochondrial membrane potential nor the expression levels of

  2. Carboxylation and anaplerosis in neurons and glia.

    Science.gov (United States)

    Hassel, B

    2000-01-01

    Anaplerosis, or de novo formation of intermediates of the tricarboxylic acid (TCA) cycle, compensates for losses of TCA cycle intermediates, especially alpha-ketoglutarate, from brain cells. Loss of alpha-ketoglutarate occurs through release of glutamate and GABA from neurons and through export of glutamine from glia, because these amino acids are alpha-ketoglutarate derivatives. Anaplerosis in the brain may involve four different carboxylating enzymes: malic enzyme, phosphoenopyruvate carboxykinase (PEPCK), propionyl-CoA carboxylase, and pyruvate carboxylase. Anaplerotic carboxylation was for many years thought to occur only in glia through pyruvate carboxylase; therefore, loss of transmitter glutamate and GABA from neurons was thought to be compensated by uptake of glutamine from glia. Recently, however, anaplerotic pyruvate carboxylation was demonstrated in glutamatergic neurons, meaning that these neurons to some extent can maintain transmitter synthesis independently of glutamine. Malic enzyme, which may carboxylate pyruvate, was recently detected in neurons. The available data suggest that neuronal and glial pyruvate carboxylation could operate at as much as 30% and 40-60% of the TCA cycle rate, respectively. Cerebral carboxylation reactions are probably balanced by decarboxylation reactions,, because cerebral CO2 formation equals O2 consumption. The finding of pyruvate carboxylation in neurons entails a major revision of the concept of the glutamine cycle. PMID:11414279

  3. Cardiac anaplerosis in health and disease: food for thought

    OpenAIRE

    Des Rosiers, Christine; Labarthe, François; Lloyd, Steven G.; Chatham, John C.

    2011-01-01

    There has been a resurgence of interest for the field of cardiac metabolism catalysed by the increased need for new therapeutic targets for patients with heart failure. The primary focus of research in this area to date has been on the impact of substrate selection for oxidative energy metabolism; however, anaplerotic metabolism also has significant interest for its potential cardioprotective role. Anaplerosis refers to metabolic pathways that replenish the citric acid cycle intermediates, wh...

  4. Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition.

    Science.gov (United States)

    Jeong, Seung Min; Hwang, Sunsook; Park, Kyungsoo; Yang, Seungyeon; Seong, Rho Hyun

    2016-01-01

    Cancer cells use precursors derived from tricarboxylic acid (TCA) cycle to support their unlimited growth. However, continuous export of TCA cycle intermediates results in the defect of mitochondrial integrity. Mitochondria glutamine metabolism plays an essential role for the maintenance of mitochondrial functions and its biosynthetic roles by refilling the mitochondrial carbon pool. Here we report that human pancreatic ductal adenocarcinoma (PDAC) cells have a distinct dependence on mitochondrial glutamine metabolism. Whereas glutamine flux into mitochondria contributes to proliferation of most cancer cells, enhanced glutamine anaplerosis results in a pronounced suppression of PDAC growth. A cell membrane permeable α-ketoglutarate analog or overexpression of glutamate dehydrogenase lead to decreased proliferation and increased apoptotic cell death in PDAC cells but not other cancer cells. We found that enhanced glutamine anaplerosis inhibits autophagy, required for tumorigenic growth of PDAC, by activating mammalian TORC1. Together, our results reveal that glutamine anaplerosis is a crucial regulator of growth and survival of PDAC cells, which may provide novel therapeutic approaches to treat these cancers. PMID:27477484

  5. Spectroscopic studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis

    Czech Academy of Sciences Publication Activity Database

    Bednárová, Lucie; Machová, Iva; Kopecký, Jr., V.; Pazderková, Markéta; Snášel, Jan; Dostál, Jiří; Hubálek, Martin; Pichová, Iva

    Bochum: Ruhr-University Bochum, 2015. s. 221. [European Conference on the Spectroscopy of Biological Molecules /16./. 06.09.2015-10.09.2015, Bochum] R&D Projects: GA MŠk LO1302 Institutional support: RVO:61388963 Keywords : phosphoenolpyruvate carboxykinase * tuberculosis * molecular spectroscopy * circular dichroism * Raman spectroscopy Subject RIV: CE - Biochemistry

  6. Spectroscopic studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis

    Czech Academy of Sciences Publication Activity Database

    Bednárová, Lucie; Machová, Iva; Snášel, Jan; Dostál, Jiří; Hubálek, Martin; Pichová, Iva

    2015-01-01

    Roč. 22, č. 1 (2015), s. 16. ISSN 1211-5894. [Discussions in Structural Molecular Biology . Annual Meeting of the Czech Society for Structural Biology /13./. 19.03.2015-21.03.2015, Nové Hrady] R&D Projects: GA MŠk LO1302 Institutional support: RVO:61388963 Keywords : phosphoenolpyruvate carboxykinase * structure * thiol * Raman spectroscopy * circular dichroism Subject RIV: CE - Biochemistry

  7. Propionate induces the bovine cytosolic phosphoenolpyruvate carboxykinase promoter activity.

    Science.gov (United States)

    Zhang, Qian; Koser, Stephanie L; Donkin, Shawn S

    2016-08-01

    Cytosolic phosphoenolpyruvate carboxykinase (PCK1) is a critical enzyme within the metabolic networks for gluconeogenesis, hepatic energy metabolism, and tricarboxylic acid cycle function, and is controlled by several transcription factors including hepatic nuclear factor 4α (HNF4α). The primary objective of the present study was to determine whether propionate regulates bovine PCK1 transcription. The second objective was to determine the action of cyclic AMP (cAMP), glucocorticoids, and insulin, hormonal cues known to modulate glucose metabolism, on bovine PCK1 transcriptional activity. The proximal promoter of the bovine PCK1 gene was ligated to a Firefly luciferase reporter and transfected into H4IIE hepatoma cells. Cells were exposed to treatments for 23 h and luciferase activity was determined in cell lysates. Activity of the PCK1 promoter was linearly induced by propionate, and maximally increased 7-fold with 2.5 mM propionate, which was not muted by 100 nM insulin. Activity of the PCK1 promoter was increased 1-fold by either 1.0 mM cAMP or 5.0µM dexamethasone, and 2.2-fold by their combination. Induction by cAMP and dexamethasone was repressed 50% by 100 nM insulin. Propionate, cAMP, and dexamethasone acted synergistically to induce the PCK1 promoter activity. Propionate-responsive regions, identified by 5' deletion analysis, were located between -1,238 and -409 bp and between -85 and +221 bp. Deletions of the core sequences of the 2 putative HNF4α sites decreased the responsiveness to propionate by approximately 40%. These data indicate that propionate regulates its own metabolism through transcriptional stimulation of the bovine PCK1 gene. This induction is mediated, in part, by the 2 putative HNF4α binding sites in the bovine PCK1 promoter. PMID:27289145

  8. Developmentally regulated interactions of liver nuclear factors with the rat phosphoenolpyruvate carboxykinase promoter.

    OpenAIRE

    Trus, M; Benvenisty, N; Cohen, H.; Reshef, L.

    1990-01-01

    A sequential pattern of interactions of trans-acting factors in rat liver with the phosphoenolpyruvate carboxykinase promoter during late development was observed. A liver-enriched factor, possibly AF1, interacted with the promoter in fetal liver, whereas a factor with the characteristics of C/EBP bound the promoter after birth with the onset of the gene expression.

  9. Mycobacterium tuberculosis Phosphoenolpyruvate Carboxykinase Is Regulated by Redox Mechanisms and Interaction with Thioredoxin

    Czech Academy of Sciences Publication Activity Database

    Machová, Iva; Snášel, Jan; Zimmermann, M.; Laubitz, D.; Plocinski, P.; Oehlmann, W.; Singh, M.; Dostál, Jiří; Sauer, U.; Pichová, Iva

    2014-01-01

    Roč. 289, č. 19 (2014), s. 13066-13078. ISSN 0021-9258 EU Projects: European Commission(XE) 241587 - SYSTEMTB Grant ostatní: OPPK(CZ) CZ.2.16/3.1.00/24016 Institutional support: RVO:61388963 Keywords : enzyme kinetics * hypoxia * metabolism * Mycobacterium tuberculosis * oxidation-reduction * thioredoxin * Phosphoenolpyruvate carboxykinase Subject RIV: CE - Biochemistry Impact factor: 4.573, year: 2014

  10. Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene.

    OpenAIRE

    Imai, E; Stromstedt, P E; Quinn, P G; Carlstedt-Duke, J; Gustafsson, J.A.; Granner, D K

    1990-01-01

    The minimal DNA sequence required for glucocorticoid induction of the phosphoenolpyruvate carboxykinase (PEPCK) gene in H4IIE rat hepatoma cells was defined. This novel glucocorticoid response unit (GRU) spans about 110 base pairs (bp) and includes two receptor-binding elements plus two accessory factor-binding elements. Purified glucocorticoid receptor bound to two regions (GR1 and GR2) between -395 and -349 bp relative to the transcription start site. Factors in crude rat liver nuclear extr...

  11. The role of phosphoenolpyruvate carboxykinase in a marine macroalga with C4-like photosynthetic characteristics.

    OpenAIRE

    Reiskind, J B; Bowes, G.

    1991-01-01

    Udotea flabellum is a marine, macroscopic green alga with C4-like photosynthetic characteristics, including little O2 inhibition of photosynthesis, a low CO2 compensation point, and minimal photorespiration; but it lacks anatomical features analogous to the Kranz compartmentation of C4 plants, and phosphoenolpyruvate carboxylase [PEPC; orthophosphate:oxaloacetate carboxy-lyase (phosphorylating), EC 4.1.1.31] activity is negligible. Phosphoenolpyruvate carboxykinase (PEPCK) activity (carboxyla...

  12. Structure of a GTP-dependent Bacterial PEP-carboxykinase from Corynebacterium glutamicum

    Energy Technology Data Exchange (ETDEWEB)

    Aich, Sanjukta; Prasad, Lata; Delbaere, Louis T.J. (Saskatchewan)

    2008-06-23

    GTP-dependent phosphoenolpyruvate carboxykinase (PCK) is the key enzyme that controls the blood glucose level during fasting in higher animals. Here we report the first substrate-free structure of a GTP-dependent phosphoenolpyruvate (PEP) carboxykinase from a bacterium, Corynebacterium glutamicum (CgPCK). The protein crystallizes in space group P2{sub 1} with four molecules per asymmetric unit. The 2.3 {angstrom} resolution structure was solved by molecular replacement using the human cytosolic PCK (hcPCK) structure (PDB ID: 1KHF) as the starting model. The four molecules in the asymmetric unit pack as two dimers, and is an artifact of crystal packing. However, the P-loop and the guanine binding loop of the substrate-free CgPCK structure have different conformations from the other published GTP-specific PCK structures, which all have bound substrates and/or metal ions. It appears that a change in the P-loop and guanine binding loop conformation is necessary for substrate binding in GTP-specific PCKs, as opposed to overall domain movement in ATP-specific PCKs.

  13. Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus

    Energy Technology Data Exchange (ETDEWEB)

    Ludwig, D.S. [Beth Israel Hospital, Boston, MA (United States)]|[Children`s Hospital, Boston, MA (United States); Vidal-Puig, A.; Moller, D.E. [Beth Israel Hospital, Boston, MA (United States)] [and others

    1996-02-01

    Expression of phosphoenolpyruvate carboxykinase (PEPCK), a rate-limiting enzyme in gluconeogenesis, is under dominant negative regulation by insulin. In this study, we sought to test the hypothesis that mutations in the PEPCK gene promoter may impair the ability of insulin to suppress hepatic glucose production, thereby contributing to both the insulin resistance and increased rate of gluconeogenesis characteristic of NIDDM. The proximal PEPCK promoter region in 117 patients with noninsulin-dependent diabetes mellitus and 20 obese Pima Indians was amplified by PCR and analyzed with single strand conformation of polymorphism techniques. In addition, limited direct DNA sequencing was performed on the insulin response sequence and flanking regions. No DNA sequence polymorphisms were found in any patient. This result suggests that mutations in cis-acting PEPCK gene regulatory elements do not constitute a common cause of noninsulin-dependent diabetes mellitus. The significance of genetic variation in promoter regions to human disease is discussed. 40 refs., 1 figs., 1 tab.

  14. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb’s cycle flux independent of ATP synthesis

    International Nuclear Information System (INIS)

    Highlights: ► We studied media effects on mechanisms of insulin secretion of INS-1 cells. ► Insulin secretion was higher in DMEM than KRB despite identical ATP synthesis rates. ► Insulin secretion rates correlated with rates of anaplerosis and TCA cycle. ► Mitochondria metabolism and substrate cycles augment secretion signal of ATP. -- Abstract: Mechanistic models of glucose stimulated insulin secretion (GSIS) established in minimal media in vitro, may not accurately describe the complexity of coupling metabolism with insulin secretion that occurs in vivo. As a first approximation, we have evaluated metabolic pathways in a typical growth media, DMEM as a surrogate in vivo medium, for comparison to metabolic fluxes observed under the typical experimental conditions using the simple salt-buffer of KRB. Changes in metabolism in response to glucose and amino acids and coupling to insulin secretion were measured in INS-1 832/13 cells. Media effects on mitochondrial function and the coupling efficiency of oxidative phosphorylation were determined by fluorometrically measured oxygen consumption rates (OCRs) combined with 31P NMR measured rates of ATP synthesis. Substrate preferences and pathways into the TCA cycle, and the synthesis of mitochondrial 2nd messengers by anaplerosis were determined by 13C NMR isotopomer analysis of the fate of [U-13C] glucose metabolism. Despite similar incremental increases in insulin secretion, the changes of OCR in response to increasing glucose from 2.5 to 15 mM were blunted in DMEM relative to KRB. Basal and stimulated rates of insulin secretion rates were consistently higher in DMEM, while ATP synthesis rates were identical in both DMEM and KRB, suggesting greater mitochondrial uncoupling in DMEM. The relative rates of anaplerosis, and hence synthesis and export of 2nd messengers from the mitochondria were found to be similar in DMEM to those in KRB. And, the correlation of total PC flux with insulin secretion rates in DMEM was

  15. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Cline, Gary W., E-mail: gary.cline@yale.edu [The Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 (United States); Department of Surgery, University of Minnesota-Twin Cities, Minneapolis, MN 55455 (United States); Pongratz, Rebecca L.; Zhao, Xiaojian [The Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 (United States); Papas, Klearchos K. [Department of Surgery, University of Minnesota-Twin Cities, Minneapolis, MN 55455 (United States)

    2011-11-11

    Highlights: Black-Right-Pointing-Pointer We studied media effects on mechanisms of insulin secretion of INS-1 cells. Black-Right-Pointing-Pointer Insulin secretion was higher in DMEM than KRB despite identical ATP synthesis rates. Black-Right-Pointing-Pointer Insulin secretion rates correlated with rates of anaplerosis and TCA cycle. Black-Right-Pointing-Pointer Mitochondria metabolism and substrate cycles augment secretion signal of ATP. -- Abstract: Mechanistic models of glucose stimulated insulin secretion (GSIS) established in minimal media in vitro, may not accurately describe the complexity of coupling metabolism with insulin secretion that occurs in vivo. As a first approximation, we have evaluated metabolic pathways in a typical growth media, DMEM as a surrogate in vivo medium, for comparison to metabolic fluxes observed under the typical experimental conditions using the simple salt-buffer of KRB. Changes in metabolism in response to glucose and amino acids and coupling to insulin secretion were measured in INS-1 832/13 cells. Media effects on mitochondrial function and the coupling efficiency of oxidative phosphorylation were determined by fluorometrically measured oxygen consumption rates (OCRs) combined with {sup 31}P NMR measured rates of ATP synthesis. Substrate preferences and pathways into the TCA cycle, and the synthesis of mitochondrial 2nd messengers by anaplerosis were determined by {sup 13}C NMR isotopomer analysis of the fate of [U-{sup 13}C] glucose metabolism. Despite similar incremental increases in insulin secretion, the changes of OCR in response to increasing glucose from 2.5 to 15 mM were blunted in DMEM relative to KRB. Basal and stimulated rates of insulin secretion rates were consistently higher in DMEM, while ATP synthesis rates were identical in both DMEM and KRB, suggesting greater mitochondrial uncoupling in DMEM. The relative rates of anaplerosis, and hence synthesis and export of 2nd messengers from the mitochondria were found

  16. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis.

    Science.gov (United States)

    Cline, Gary W; Pongratz, Rebecca L; Zhao, Xiaojian; Papas, Klearchos K

    2011-11-11

    Mechanistic models of glucose stimulated insulin secretion (GSIS) established in minimal media in vitro, may not accurately describe the complexity of coupling metabolism with insulin secretion that occurs in vivo. As a first approximation, we have evaluated metabolic pathways in a typical growth media, DMEM as a surrogate in vivo medium, for comparison to metabolic fluxes observed under the typical experimental conditions using the simple salt-buffer of KRB. Changes in metabolism in response to glucose and amino acids and coupling to insulin secretion were measured in INS-1 832/13 cells. Media effects on mitochondrial function and the coupling efficiency of oxidative phosphorylation were determined by fluorometrically measured oxygen consumption rates (OCRs) combined with (31)P NMR measured rates of ATP synthesis. Substrate preferences and pathways into the TCA cycle, and the synthesis of mitochondrial 2nd messengers by anaplerosis were determined by (13)C NMR isotopomer analysis of the fate of [U-(13)C] glucose metabolism. Despite similar incremental increases in insulin secretion, the changes of OCR in response to increasing glucose from 2.5 to 15mM were blunted in DMEM relative to KRB. Basal and stimulated rates of insulin secretion rates were consistently higher in DMEM, while ATP synthesis rates were identical in both DMEM and KRB, suggesting greater mitochondrial uncoupling in DMEM. The relative rates of anaplerosis, and hence synthesis and export of 2nd messengers from the mitochondria were found to be similar in DMEM to those in KRB. And, the correlation of total PC flux with insulin secretion rates in DMEM was found to be congruous with the correlation in KRB. Together, these results suggest that signaling mechanisms associated with both TCA cycle flux and with anaplerotic flux, but not ATP production, may be responsible for the enhanced rates of insulin secretion in more complex, and physiologically-relevant media. PMID:22008547

  17. Phosphoenolpyruvate Carboxykinase 1 Gene (Pck1) Displays Parallel Evolution between Old World and New World Fruit Bats

    OpenAIRE

    Zhu, Lei; Yin, Qiuyuan; Irwin, David M.; Zhang, Shuyi

    2015-01-01

    Bats are an ideal mammalian group for exploring adaptations to fasting due to their large variety of diets and because fasting is a regular part of their life cycle. Mammals fed on a carbohydrate-rich diet experience a rapid decrease in blood glucose levels during a fast, thus, the development of mechanisms to resist the consequences of regular fasts, experienced on a daily basis, must have been crucial in the evolution of frugivorous bats. Phosphoenolpyruvate carboxykinase 1 (PEPCK1, encoded...

  18. Interaction of a liver-specific factor with an enhancer 4.8 kilobases upstream of the phosphoenolpyruvate carboxykinase gene.

    OpenAIRE

    Ip, Y T; Poon, D; Stone, D.; Granner, D K; Chalkley, R

    1990-01-01

    We have previously identified a series of five DNase-I hypersensitive (HS) sites within and around the rat phosphoenolpyruvate carboxykinase (PEPCK) gene. The far upstream region has now been sequenced, and the tissue-specific HS site has been mapped more precisely at 4,800 base pairs upstream of the transcription start site of the PEPCK gene. DNA fragments that include the HS site were cloned upstream of various promoters to test whether these regions modulate transcription of the chloramphe...

  19. Substrate trapping experiments with P-enolpyruvate carboxykinase from rat and chickel liver

    International Nuclear Information System (INIS)

    Equilibrium mixtures of P-enolpyruvate carboxykinase (PEPCK) and Mg[α-32P]GTP were mixed with excess oxalacetate and unlabeled MgGTP to establish the fraction of bound GTP which is commited to product formation. At saturating oxalacetate all enzyme-bound [α-32P]GTP was converted to [α-32P]GDP, thus the rate of catalysis is much greater than the dissociation of the PEPCK x MgGTP complex. The concentration of oxalacetate which caused half of the bound GTP to be trapped was 10-20 μM. Control experiments established that no significant conversion of GTP → GDP occurred in the absence of oxalacetate and no evidence was found for a covalent enzyme-phosphoryl complex. Similar results were obtained with both rat and chicken liver PEPCK's. The presence of Mn2+ (in addition to Mg2+) or the presence of KHCO3 had no effect on the GTP trapping efficiency. These experiments confirm kinetic studies which indicated that catalysis is not the slow step for the reaction catalyzed by PEPCK and establish that MgGTP binds in the proper catalytic orientation in the absence of oxalacetate, Mn2+ or HCO3-

  20. Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.

    Science.gov (United States)

    Santra, Saikat; Cameron, Jessie M; Shyr, Casper; Zhang, Linhua; Drögemöller, Britt; Ross, Colin J; Wasserman, Wyeth W; Wevers, Ron A; Rodenburg, Richard J; Gupte, Girish; Preece, Mary Anne; van Karnebeek, Clara D

    2016-05-01

    We report a patient from a consanguineous family who presented with transient acute liver failure and biochemical patterns suggestive of disturbed urea cycle and mitochondrial function, for whom conventional genetic and metabolic investigations for acute liver failure failed to yield a diagnosis. Whole exome sequencing revealed a homozygous 12-bp deletion in PCK1 (MIM 614168) encoding cytosolic phosphoenolpyruvate carboxykinase (PEPCK); enzymatic studies subsequently confirmed its pathogenic nature. We propose that PEPCK deficiency should be considered in the young child with unexplained liver failure, especially where there are marked, accumulations of TCA cycle metabolites on urine organic acid analysis and/or an amino acid profile with hyperammonaemia suggestive of a proximal urea cycle defect during the acute episode. If suspected, intravenous administration of dextrose should be initiated. Long-term management comprising avoidance of fasting with the provision of a glucose polymer emergency regimen for illness management may be sufficient to prevent future episodes of liver failure. This case report provides further insights into the (patho-)physiology of energy metabolism, confirming the power of genomic analysis of unexplained biochemical phenotypes. PMID:26971250

  1. An assessment of the capacity for phosphoenolpyruvate carboxykinase to contribute to C4 photosynthesis.

    Science.gov (United States)

    Koteyeva, Nuria K; Voznesenskaya, Elena V; Edwards, Gerald E

    2015-06-01

    Three C4 acid decarboxylases, phosphoenolpyruvate carboxykinase (PEPCK), NADP-malic enzyme (NADP-ME), and NAD-malic enzyme (NAD-ME) were recruited from C3 plants to support C4 photosynthesis. In Poaceae, there are established lineages having PEPCK type species, and some NADP-ME lineages in which PEPCK contributes to C4. Besides family Poaceae, recently PEPCK has been reported to function in C4 photosynthesis in eudicot species including Cleome gynandra (Cleomaceae), Trianthema portulacastrum and Zaleya pentandra (Aizoaceae). We evaluated PEPCK by enzyme assay and western blots in representatives of Poaceae, Aizoaceae, Cleomaceae, and Chenopodiaceae compared to that in the PEPCK type C4 grass Spartina anglica. Eragrostis nutans was identified as the first NAD-ME type C4 grass having substantial amounts of PEPCK. In the eudicots, including C. gynandra, Cleome angustifolia, T. portulacastrum, Z. pentandra, and nine C4 members of family Chenopodiaceae (which has the most C4 species and diversity in forms among eudicot families), amounts of PEPCK were generally very low (barely detectable up to 4% of that in S. anglica). Based on these results, C4 species can be classified biochemically according to the dominant decarboxylase recruited for C4 function; and, Poaceae remains the only family in which PEPCK is known to have a significant role in C4 photosynthesis. PMID:25900567

  2. Gluconeogenesis in Leishmania mexicana: contribution of glycerol kinase, phosphoenolpyruvate carboxykinase, and pyruvate phosphate dikinase.

    Science.gov (United States)

    Rodriguez-Contreras, Dayana; Hamilton, Nicklas

    2014-11-21

    Gluconeogenesis is an active pathway in Leishmania amastigotes and is essential for their survival within the mammalian cells. However, our knowledge about this pathway in trypanosomatids is very limited. We investigated the role of glycerol kinase (GK), phosphoenolpyruvate carboxykinase (PEPCK), and pyruvate phosphate dikinase (PPDK) in gluconeogenesis by generating the respective Leishmania mexicana Δgk, Δpepck, and Δppdk null mutants. Our results demonstrated that indeed GK, PEPCK, and PPDK are key players in the gluconeogenesis pathway in Leishmania, although stage-specific differences in their contribution to this pathway were found. GK participates in the entry of glycerol in promastigotes and amastigotes; PEPCK participates in the entry of aspartate in promastigotes, and PPDK is involved in the entry of alanine in amastigotes. Furthermore, the majority of alanine enters into the pathway via decarboxylation of pyruvate in promastigotes, whereas pathway redundancy is suggested for the entry of aspartate in amastigotes. Interestingly, we also found that l-lactate, an abundant glucogenic precursor in mammals, was used by Leishmania amastigotes to synthesize mannogen, entering the pathway through PPDK. On the basis of these new results, we propose a revision in the current model of gluconeogenesis in Leishmania, emphasizing the differences between amastigotes and promastigotes. This work underlines the importance of studying the trypanosomatid intracellular life cycle stages to gain a better understanding of the pathologies caused in humans. PMID:25288791

  3. Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus.

    Science.gov (United States)

    Wu, J; Hou, S S; Wang, W; Yin, M; Cheng, N; Ge, L L; Yin, J J; Xu, J

    2015-01-01

    The objective of this study was to investigate the mRNA expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM). Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into the GBS, sham operation with diet restriction (SO), and sham operation alone (control) groups (N = 12 per group). Liver specimens from all rats were obtained during the operation and 8 weeks after operation. Blood lipid levels were measured before and 8 weeks after operation. Fasting blood glucose (FBG), food intake, and body weight were recorded at weekly time points after operation. The blood glucose area under the curve (AUC) was calculated, and insulin sensitivity indices (ISI) were assessed. The expression PEPCK mRNA and protein were measured by real-time polymerase chain reaction and western blot. Compared with those of the SO and control groups, the blood lipid levels and the FBG in the GBS group was significantly decreased (P rats while improving glucose tolerance and hyperglycemia, and the mechanism appears to be associated with a decrease of hepatic PEPCK mRNA and protein expression. PMID:26681041

  4. Phosphoenolpyruvate carboxykinase in bovine tick Rhipicephalus (Boophilus) micro plus embryogenesis and starvation larvae

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, J.G. de; Mentizingen, L.G.; Logullo, C. [Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, RJ (Brazil). Centro de Biociencias e Biotecnologia. Lab.de Quimica e Funcao de Proteinas e Peptideos (LQFPP); Andrade, C.P. de; Vaz Junior, Itabajara [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Centro de Biotecnologia; Daffre, S.; Esteves, E. [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Ciencias Biomedicas

    2008-07-01

    Full text: Phosphoenolpyruvate carboxykinase (PEPCK) is considered a key rate controlling enzyme in gluconeogenesis pathway. Gluconeogenesis is a highly regulated process, catalyzed by several enzymes subject to regulation by insulin. Normally, insulin rapidly and substantially inhibits PEPCK gene transcription and the PEPCK activity is proportional to the rate of gene transcription. The transcriptional regulation of the PEPCK gene has been extensively studied. CREM is the transcription factor that bind efficiently to the putative cyclic AMP response element (CRE) in PEPCK gene. Several other transcription factors can bind to this element and activate transcription. In oviparous animals, such as bovine tick R. microplus, the embryonic development occurs outside the maternal organism, implying that all the nutrients necessary for embryogenesis must be present in the oocytes. We observed the relationship between the main energy sources and the morphogenetic changes that occur during R. microplus tick embryogenesis. Energy homeostasis is maintained by glycogen mobilization in the beginning of embryogenesis, as its content is drastically decreased during the first five days of development. Afterwards, the activity of the gluconeogenesis enzyme PEPCK increases enormously, as indicated by a concomitant increase in glucose content (Moraes et al., 2007). Here, we analyzed PEPCK gene transcription by qPCR during the embryogenesis and starvation larvae. The PEPCK transcription was higher at first and 15th day eggs of the development. In larvae the levels of PEPCK transcripts is increased at fifth day after hatch. However, the activity is continuous increased in larvae the form first up to 15th day. Now we are investigating the involvement of CREM in the PEPCK gene transcription in these cells. In this sense, we obtained CREM sequence from TIGR ESTs R. microplus bank and designed the specific primers to qPCR. Taken together our results suggest the involvement of PEPCK to the

  5. Hepatic Subcellular Compartmentation of Cytoplasmic Phosphoenolpyruvate Carboxykinase Determined by Immunogold Electron Microscopy

    Science.gov (United States)

    Gao, Kuixiong; Cardell, Emma Lou; Morris, Randal E.; Giffin, Bruce F.; Cardell, Robert R.

    1995-08-01

    Phosphoenolpyruvate carboxykinase (PEPCK) is the rate-limiting gluconeogenic enzyme and in liver occurs in a lobular gradient from periportal to pericentral regions. The subcellular distribution of cytoplasmic PEPCK molecules within hepatocytes and its relationship to organelles have not been determined previously. In this study, we have used immunogold electron microscopy to evaluate the subcellar distribution of the enzyme, in addition to brightfield and epipolarized light microscopy. Cryosections (10 [mu]m) of perfusion-fixed rat liver were collected on silanated slides and immunostained using goat anti-rat PEPCK followed by 5-nm gold-labeled secondary and tertiary antibodies. Additionally, free-floating vibratome sections (25, 50, and 100 [mu]m) of perfusion-immersion-fixed rat liver were immunogold stained using goat anti-rat PEPCK and 5-nm gold-labeled secondary antibody, with and without silver enhancement. The immunogold labeled sections from both procedures were embedded in epoxy resin for the preparation of thin sections for electron microscopy. The results showed that the gold-labeled antibodies penetrated the entire thickness of cryosections, resulting in a high signal for PEPCK, but membranes in general, the smooth endoplasmic reticulum in particular, were not identifiable as electron dense unit membranes. On the other hand, the vibratome sections of well-fixed tissue allowed good visualization of the ultrastructure of cellular organelles, with the smooth endoplasmic reticulum appearing as vesicles and tubules with electron dense unit membranes; however, the penetration of the gold-labeled antibody was limited to cells at the surface of the vibratome sections. In both procedures, PEPCK, as indicated by gold particles, is predominantly in the glycogen areas of the cytosome and not in mitochondria, nuclei, Golgi apparatus, or other cell organelles. Hepatocytes in periportal regions have a compact subcellular distribution of PEPCK shown by gold particles

  6. The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids.

    OpenAIRE

    Hall, R K; Sladek, F M; Granner, D K

    1995-01-01

    Glucocorticoids stimulate hepatic phosphoenolpyruvate carboxykinase (PEPCK; EC 4.1.1.32) gene expression, thereby increasing the rate of gluconeogenesis. The effect of glucocorticoids on PEPCK gene expression is mediated by a set of promoter elements collectively referred to as the glucocorticoid response unit. The response unit spans a 100-bp segment and includes two glucocorticoid receptor binding sites (GR1 and GR2) and two accessory factor binding sites (AF1 and AF2), all of which are req...

  7. Phosphoenolpyruvate carboxykinase (PEPCK) deficiency affects the germination, growth and fruit sugar content in tomato (Solanum lycopersicum L.).

    Science.gov (United States)

    Huang, Yong-Xing; Yin, Yong-Gen; Sanuki, Atsuko; Fukuda, Naoya; Ezura, Hiroshi; Matsukura, Chiaki

    2015-11-01

    Phosphoenolpyruvate carboxykinase (PEPCK) is a key regulatory enzyme and is utilized in the gluconeogenesis pathway in plants. Although, its catalytic and regulatory properties are quite well understood, there are uncertainties regarding its physiological role in many plants tissues such as the flesh of developing fruits. To further understand the function of PEPCK in fruits and other tissues, RNAi transgenic tomato plants in which SlPEPCK transcription was down-regulated by either CaMV 35S constitutive promoter or the fruit-specific E8 promoter were generated and characterized on the basis of their phenotypic and metabolic aspects. In the PEPCK-deficient lines, prominent growth suppression of germinated seedlings was observed and other vegetative suppression appeared during the early stage of plant growth in the 35S promoter-driven lines. In particular, root elongation was most obviously suppressed in the germinated seedlings, indicating that the gluconeogenesis pathway is involved in the root growth of seedlings. Regarding the primary metabolism in fruit, the soluble sugar content tended to decrease, whereas the malate content tended to increase in ripening fruits of the RNAi lines compared with the wild type. These results indicate that activation of the gluconeogenesis pathway from organic acids to sugars occurs during ripening but is suppressed by the knocking down of the PEPCK gene, suggesting that PEPCK participates in determining the sugar/acid ratio in ripening fruit. PMID:26381194

  8. Cloning and expression of phosphoenolpyruvate carboxykinase from a cestode parasite and its solubilization from inclusion bodies using l-arginine.

    Science.gov (United States)

    Dutta, Asim K; Ramnath; Dkhar, Barilin; Tandon, Veena; Das, Bidyadhar

    2016-09-01

    Phosphoenolpyruvate carboxykinase is an essential regulatory enzyme of glycolysis in the cestode parasite, Raillietina echinobothrida, and is considered a potential target for anthelmintic action because of its differential activity from that of its avian host. However, due to the unavailability of its structure, the mechanism of regulation of PEPCK from R. echinobothrida (rePEPCK) and its interaction with possible modulators remain unclear. Hence, in this study, the rePEPCK gene was cloned into pGEX-4T-3 and overexpressed for its characterization. On being induced by IPTG, the recombinant rePEPCK was expressed as inclusion bodies (IBs); hence, various agents, like different inducer concentrations, temperature, time, host cell types, culture media, pH, and additives, were used to bring the protein to soluble form. Finally, a significant amount (∼46%) of rePEPCK was solubilized from IBs by adding 2M l-arginine. Near-UV circular dichroism spectra analysis indicated that l-arginine (2M) had no effect on the conformation of the protein. In this study, we have reported a yield of ∼73mg of purified rePEPCK per 1L of culture. The purified rePEPCK retained its biological activity, and Km of the enzyme for its substrate was determined and discussed. The availability of recombinant rePEPCK may help in biochemical- and biophysical-studies to explore its molecular mechanisms and regulations. PMID:26363119

  9. Phosphoenolpyruvate carboxykinase 1 gene (Pck1) displays parallel evolution between Old World and New World fruit bats.

    Science.gov (United States)

    Zhu, Lei; Yin, Qiuyuan; Irwin, David M; Zhang, Shuyi

    2015-01-01

    Bats are an ideal mammalian group for exploring adaptations to fasting due to their large variety of diets and because fasting is a regular part of their life cycle. Mammals fed on a carbohydrate-rich diet experience a rapid decrease in blood glucose levels during a fast, thus, the development of mechanisms to resist the consequences of regular fasts, experienced on a daily basis, must have been crucial in the evolution of frugivorous bats. Phosphoenolpyruvate carboxykinase 1 (PEPCK1, encoded by the Pck1 gene) is the rate-limiting enzyme in gluconeogenesis and is largely responsible for the maintenance of glucose homeostasis during fasting in fruit-eating bats. To test whether Pck1 has experienced adaptive evolution in frugivorous bats, we obtained Pck1 coding sequence from 20 species of bats, including five Old World fruit bats (OWFBs) (Pteropodidae) and two New World fruit bats (NWFBs) (Phyllostomidae). Our molecular evolutionary analyses of these sequences revealed that Pck1 was under purifying selection in both Old World and New World fruit bats with no evidence of positive selection detected in either ancestral branch leading to fruit bats. Interestingly, however, six specific amino acid substitutions were detected on the ancestral lineage of OWFBs. In addition, we found considerable evidence for parallel evolution, at the amino acid level, between the PEPCK1 sequences of Old World fruit bats and New World fruit bats. Test for parallel evolution showed that four parallel substitutions (Q276R, R503H, I558V and Q593R) were driven by natural selection. Our study provides evidence that Pck1 underwent parallel evolution between Old World and New World fruit bats, two lineages of mammals that feed on a carbohydrate-rich diet and experience regular periods of fasting as part of their life cycle. PMID:25807515

  10. Phosphoenolpyruvate Carboxykinase, a Key Enzyme That Controls Blood Glucose, Is a Target of Retinoic Acid Receptor-Related Orphan Receptor α.

    Directory of Open Access Journals (Sweden)

    Hiroshi Matsuoka

    Full Text Available Phosphoenolpyruvate carboxykinase (PEPCK catalyzes a committed and rate-limiting step in hepatic gluconeogenesis, and its activity is tightly regulated to maintain blood glucose levels within normal limits. PEPCK activity is primarily regulated through hormonal control of gene transcription. Transcription is additionally regulated via a cAMP response unit, which includes a cAMP response element and four binding sites for CCAAT/enhancer-binding protein (C/EBP. Notably, the cAMP response unit also contains a putative response element for retinoic acid receptor-related orphan receptor α (RORα. In this paper, we characterize the effect of the RORα response element on cAMP-induced transcription. Electrophoresis mobility shift assay indicates that RORα binds this response element in a sequence-specific manner. Furthermore, luciferase reporter assays indicate that RORα interacts with C/EBP at the PEPCK promoter to synergistically enhance transcription. We also found that cAMP-induced transcription depends in part on RORα and its response element. In addition, we show that suppression of RORα by siRNA significantly decreased PEPCK transcription. Finally, we found that a RORα antagonist inhibits hepatic gluconeogenesis in an in vitro glucose production assay. Taken together, the data strongly suggest that PEPCK is a direct RORα target. These results define possible new roles for RORα in hepatic gluconeogenesis.

  11. Formation of an intramolecular cystine disulfide during the reaction of 8-azidoguanosine 5'-triphosphate with cytosolic phosphoenolpyruvate carboxykinase (GTP) causes inactivation without photolabeling

    International Nuclear Information System (INIS)

    Phosphoenolpyruvate carboxykinase (GTP) (PEPCK) specifically utilizes a guanosine or inosine nucleotide as a substrate, yet it does not share extended sequence homology with other GTP-binding proteins, and the molecular basis for its nucleotide specificity is not understood. In an effort to locate the enzyme's nucleotide-binding site, the authors have studied the interaction of cytosolic PEPCK from rat liver with the photoprobe 8-azidoGTP, which fulfills the criteria of a specific photoaffinity label for PEPCK. The photoprobe binds reversibly to the enzyme prior to modification and at low concentrations causes greater than 60% inactivation-GTP provides nearly complete protection against inactivation by 8-azidoGTP, whereas phosphoenolpyruvate and metal ions provide partial protection. In addition, the photoprobe is a substrate for the enzyme and has a Km similar to that for GTP. However, the extent of covalent modification by [32P]8-azido-GTP as measured by three independent techniques is significantly lower than the extent of enzyme inactivation. Further investigation of this anomaly has revealed that the loss in enzymatic activity is caused by modification of a critical cysteine residue in a reaction that does not terminate with covalent attachment of the photolabel. Quantitation of the total free thiols of modified PEPCK shows that 2 mol of cysteine is lost per mole of inactivated enzyme. These results indicate that the photoinactivation of PEPCK by 8-azidoGTP is caused by the formation of an intramolecular cystine disulfide bridge, thus providing evidence for the existence of a pair of proximal cysteine residues within the GTP-binding site. The interaction of cysteine residues with the reactive photogenerated derivatives of 8-azidopurines is discussed

  12. Phosphoenolpyruvate carboxykinase, pyruvate orthophosphate dikinase and isocitrate lyase in both tomato fruits and leaves, and in the flesh of peach and some other fruits.

    Science.gov (United States)

    Famiani, Franco; Paoletti, Andrea; Battistelli, Alberto; Moscatello, Stefano; Chen, Zhi-Hui; Leegood, Richard C; Walker, Robert P

    2016-09-01

    In this study the occurrence of a number of enzymes involved in gluconeogenesis was investigated in both tomato fruits and leaves during their development and senescence and in some other fruits. The enzymes studied were phosphoenolpyruvate carboxykinase (PEPCK), pyruvate orthophosphate dikinase (PPDK) and glyoxysomal isocitrate lyase (ICL). PPDK was detected in the ripe flesh of tomato, and much smaller amounts were detected in the flesh of both peach and pepper, whereas it was not detected (not present or at very low abundance) in the other fruits which were investigated (apricot, aubergine, blackberry, blueberry, cherry, grape, plum, raspberry and red current). By contrast PEPCK was present in the flesh of all the fruits investigated. Very small amounts of ICL were detected in ripe tomato flesh. PEPCK was present in the skin, flesh, locular gel and columella of tomato fruit, and in these its abundance increased greatly during ripening. PPDK showed a similar distribution, however, its abundance did not increase during ripening. PEPCK was not detected in tomato leaves at any stage of their development or senescence. The content of PPDK g(-1) fresh weight (FW) increased in tomato leaves as they matured, however, it declined during their senescence. In tomato leaves the content of ICL g(-1) FW increased until the mid-stage of development, then decreased as the leaf matured, and then increased during the latter stages of senescence. In the flesh of tomato fruits the contents of PPDK and PEPCK g(-1) FW decreased during senescence. The results suggest that in fruits other than tomato the bulk of any gluconeogenic flux proceeds via PEPCK, whereas in tomato both PEPCK and PPDK could potentially be utilised. Further, the results indicate that the conversion of pyruvate/acetyl-CoA to malate by the glyoxylate cycle, for which ICL is necessary, is not a major pathway utilised by gluconeogenesis in fruits under normal conditions of growth. Finally, the results contribute to

  13. Scandinavian links

    DEFF Research Database (Denmark)

    Matthiessen, Christian Wichmann; Knowles, Richard D.

    The European Round Table of Industrialists identified in the 1980ies 14 missing links in the transportation network of the continent. Three of them were found around the Danish island of Zealand. One link is within the nation, the other two are between nations. One link connects heavy economic ce...

  14. Link Analysis

    Science.gov (United States)

    Donoho, Steve

    Link analysis is a collection of techniques that operate on data that can be represented as nodes and links. This chapter surveys a variety of techniques including subgraph matching, finding cliques and K-plexes, maximizing spread of influence, visualization, finding hubs and authorities, and combining with traditional techniques (classification, clustering, etc). It also surveys applications including social network analysis, viral marketing, Internet search, fraud detection, and crime prevention.

  15. The contribution of stored malate and citrate to the substrate requirements of metabolism of ripening peach (Prunus persica L. Batsch) flesh is negligible. Implications for the occurrence of phosphoenolpyruvate carboxykinase and gluconeogenesis.

    Science.gov (United States)

    Famiani, Franco; Farinelli, Daniela; Moscatello, Stefano; Battistelli, Alberto; Leegood, Richard C; Walker, Robert P

    2016-04-01

    The first aim of this study was to determine the contribution of stored malate and citrate to the substrate requirements of metabolism in the ripening flesh of the peach (Prunus persica L. Batsch) cultivar Adriatica. In the flesh, stored malate accumulated before ripening could contribute little or nothing to the net substrate requirements of metabolism. This was because there was synthesis and not dissimilation of malate throughout ripening. Stored citrate could potentially contribute a very small amount (about 5.8%) of the substrate required by metabolism when the whole ripening period was considered, and a maximum of about 7.5% over the latter part of ripening. The second aim of this study was to investigate why phosphoenolpyruvate carboxykinase (PEPCK) an enzyme utilised in gluconeogenesis from malate and citrate is present in peach flesh. The occurrence and localisation of enzymes utilised in the metabolism of malate, citrate and amino acids were determined in peach flesh throughout its development. Phosphoenolpyruvate carboxylase (essential for the synthesis of malate and citrate) was present in the same cells and at the same time as PEPCK and NADP-malic enzyme (both utilised in the dissimilation of malate and citrate). A hypothesis is presented to explain the presence of these enzymes and to account for the likely occurrence of gluconeogenesis. PMID:26852108

  16. Operative links

    DEFF Research Database (Denmark)

    Wistoft, Karen

    2010-01-01

    as networks: second, a semantic perspective on discourses and concepts of health, and, third, a health pedagogical perspective on participation, intervention, and roles. This paper argues for the importance of 'operative links' between different levels in health strategies. It is proposed that such......The article combines a public management perspective with a pedagogical perspective on health promotion. Our aim is to look into recent reforms in Denmark on health promotion in order to see how managerial ideas have been combined with welfare professional ideals concerning broad, positive and...... links are supported by network structures, shared semantics and situated pedagogical means of intervention....

  17. Operative Links

    DEFF Research Database (Denmark)

    Wistoft, Karen; Højlund, Holger

    2012-01-01

    The article combines a public management perspective with a pedagogical perspective on health promotion. Our aim is to look into recent reforms in Denmark on health promotion in order to see how managerial ideas have been combined with welfare professional ideals concerning broad, positive and...... framework has three positions: first, a policy perspective on public organisations as networks, second, a semantic perspective on discourses and concepts of health and, third, a health pedagogical perspective on participation, intervention, and roles. Conclusion: it is necessary to establish ‘operative...... links' that indicate cooperative levels which facilitate a creative and innovative effort in disease prevention and health promotion targeted at children and adolescents - across traditional professional boundaries. It is proposed that such links are supported by network structures, shared semantics and...

  18. Operative Links

    DEFF Research Database (Denmark)

    Wistoft, Karen; Højlund, Holger

    2012-01-01

    educational approaches. Methods: Mixed qualitative design: survey based on telephone interviews with health managers (n=72), personal and focus group interviews with health professionals (n=84) and pupils (n=108) from 18 school classes, and comparative case studies in five selected municipalities of various...... educational goals, learning content, or value clarification. Health pedagogy is often a matter of retrospective rationalization rather than the starting point of planning. Health and risk behaviour approaches override health educational approaches. Conclusions: Operational links between health education...

  19. Dancing links

    CERN Document Server

    Knuth, Donald E

    2009-01-01

    The author presents two tricks to accelerate depth-first search algorithms for a class of combinatorial puzzle problems, such as tiling a tray by a fixed set of polyominoes. The first trick is to implement each assumption of the search with reversible local operations on doubly linked lists. By this trick, every step of the search affects the data incrementally. The second trick is to add a ghost square that represents the identity of each polyomino. Thus puts the rule that each polyomino be used once on the same footing as the rule that each square be covered once. The coding simplifies to a more abstract form which is equivalent to 0-1 integer programming. More significantly for the total computation time, the search can naturally switch between placing a fixed polyomino or covering a fixed square at different stages, according to a combined heuristic. Finally the author reports excellent performance for his algorithm for some familiar puzzles. These include tiling a hexagon by 19 hexiamonds and the N queen...

  20. Sex-linked dominant

    Science.gov (United States)

    Inheritance - sex-linked dominant; Genetics - sex-linked dominant; X-linked dominant; Y-linked dominant ... type of chromosome that is affected (autosomal or sex chromosome). It also depends on whether the trait ...

  1. Sex-linked dominant

    Science.gov (United States)

    Inheritance - sex-linked dominant; Genetics - sex-linked dominant; X-linked dominant; Y-linked dominant ... can be either an autosomal chromosome or a sex chromosome. It also depends on whether the trait ...

  2. Linked data management

    CERN Document Server

    Hose, Katja; Schenkel, Ralf

    2014-01-01

    Linked Data Management presents techniques for querying and managing Linked Data that is available on today’s Web. The book shows how the abundance of Linked Data can serve as fertile ground for research and commercial applications. The text focuses on aspects of managing large-scale collections of Linked Data. It offers a detailed introduction to Linked Data and related standards, including the main principles distinguishing Linked Data from standard database technology. Chapters also describe how to generate links between datasets and explain the overall architecture of data integration systems based on Linked Data. A large part of the text is devoted to query processing in different setups. After presenting methods to publish relational data as Linked Data and efficient centralized processing, the book explores lookup-based, distributed, and parallel solutions. It then addresses advanced topics, such as reasoning, and discusses work related to read-write Linked Data for system interoperation. Desp...

  3. Spamming in Linked Data

    OpenAIRE

    Hasnain, Ali; Al-Bakri, Mustafa; Costabello, Luca; Cong, Zijie; Davis, Ian; Heath, Tom

    2012-01-01

    The rapidly growing commercial interest in Linked Data raises the prospect of "Linked Data spam", which we define as "deliberately misleading information (data and links) published as Linked Data, with the goal of creating financial gain for the publisher". Compared to conventional technologies affected by spamming, e.g. email and blogs, spammers targeting Linked Data may not be able to push information directly towards consumers, but rather may seek to exploit a lack of human involvement in ...

  4. Linking numbers for handlebody-links

    OpenAIRE

    Mizusawa, Atsuhiko

    2013-01-01

    As a generalization of the linking number, we construct a set of invariant numbers for two-component handlebody-links. These numbers are elementary divisors associated with the natural homomorphism from the first homology group of a component to that of the complement of another component.

  5. Weierstrass polynomials for links

    DEFF Research Database (Denmark)

    Hansen, Vagn Lundsgaard

    1997-01-01

    There is a natural way of identifying links in3-space with polynomial covering spaces over thecircle. Thereby any link in 3-space can be definedby a Weierstrass polynomial over the circle. Theequivalence relation for covering spaces over thecircle is, however, completely different from that for...... links in 3-space. This paper initiates a study of the connections between polynomial covering spaces over the circle and links in 3-space....

  6. Dynamic link: user's manual

    International Nuclear Information System (INIS)

    The purpose of dynamic link facility is to link a load module dynamically only when it is used in execution time. The facility is very useful for development, execution and maintenance of a large scale computer program which is too big to be saved as one load module in main memory, or it is poor economy to save it due to many unused subroutines depending on an input. It is also useful for standardization and common utilization of programs. Standard usage of dynamic link facility of FACOM M-200 computer system, a software tool which analyzes the effect of dynamic link facility and application of dynamic link to nuclear codes are described. (author)

  7. Links and Quantum Entanglement

    CERN Document Server

    Solomon, A I

    2011-01-01

    We discuss the analogy between topological entanglement and quantum entanglement, particularly for tripartite quantum systems. We illustrate our approach by first discussing two clearly (topologically) inequivalent systems of three-ring links: The Borromean rings, in which the removal of any one link leaves the remaining two non-linked (or, by analogy, non-entangled); and an inequivalent system (which we call the NUS link) for which the removal of any one link leaves the remaining two linked (or, entangled in our analogy). We introduce unitary representations for the appropriate Braid Group ($B_3$) which produce the related quantum entangled systems. We finally remark that these two quantum systems, which clearly possess inequivalent entanglement properties, are locally unitarily equivalent.

  8. Linking open vocabularies

    CERN Document Server

    Greifender, Elke; Seadle, Michael

    2013-01-01

    Linked Data (LD), Linked Open Data (LOD) and generating a web of data, present the new knowledge sharing frontier. In a philosophical context, LD is an evolving environment that reflects humankinds' desire to understand the world by drawing on the latest technologies and capabilities of the time. LD, while seemingly a new phenomenon did not emerge overnight; rather it represents the natural progression by which knowledge structures are developed, used, and shared. Linked Open Vocabularies is a significant trajectory of LD. Linked Open Vocabularies targets vocabularies that have traditionally b

  9. Refined Hopf Link Revisited

    CERN Document Server

    Iqbal, Amer

    2012-01-01

    We establish a relation between the refined Hopf link invariant and the S-matrix of the refined Chern-Simons theory. We show that the refined open string partition function corresponding to the Hopf link, calculated using the refined topological vertex, when expressed in the basis of Macdonald polynomials gives the S-matrix of the refined Chern-Simons theory.

  10. Linked Ocean Data

    Science.gov (United States)

    Leadbetter, Adam; Arko, Robert; Chandler, Cynthia; Shepherd, Adam

    2014-05-01

    "Linked Data" is a term used in Computer Science to encapsulate a methodology for publishing data and metadata in a structured format so that links may be created and exploited between objects. Berners-Lee (2006) outlines the following four design principles of a Linked Data system: Use Uniform Resource Identifiers (URIs) as names for things. Use HyperText Transfer Protocol (HTTP) URIs so that people can look up those names. When someone looks up a URI, provide useful information, using the standards (Resource Description Framework [RDF] and the RDF query language [SPARQL]). Include links to other URIs so that they can discover more things. In 2010, Berners-Lee revisited his original design plan for Linked Data to encourage data owners along a path to "good Linked Data". This revision involved the creation of a five star rating system for Linked Data outlined below. One star: Available on the web (in any format). Two stars: Available as machine-readable structured data (e.g. An Excel spreadsheet instead of an image scan of a table). Three stars: As two stars plus the use of a non-proprietary format (e.g. Comma Separated Values instead of Excel). Four stars: As three stars plus the use of open standards from the World Wide Web Commission (W3C) (i.e. RDF and SPARQL) to identify things, so that people can point to your data and metadata. Five stars: All the above plus link your data to other people's data to provide context Here we present work building on the SeaDataNet common vocabularies served by the NERC Vocabulary Server, connecting projects such as the Rolling Deck to Repository (R2R) and the Biological and Chemical Oceanography Data Management Office (BCO-DMO) and other vocabularies such as the Marine Metadata Interoperability Ontology Register and Repository and the NASA Global Change Master Directory to create a Linked Ocean Data cloud. Publishing the vocabularies and metadata in standard RDF XML and exposing SPARQL endpoints renders them five-star Linked

  11. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Education Projects » Learn the Link - Drugs and HIV Learn the Link - Drugs and HIV Email Facebook Twitter ... research findings and news updates. Read on to Learn the Link between drug abuse and HIV and ...

  12. Link Monotonic Allocation Schemes

    NARCIS (Netherlands)

    Slikker, M.

    1999-01-01

    A network is a graph where the nodes represent players and the links represent bilateral interaction between the players. A reward game assigns a value to every network on a fixed set of players. An allocation scheme specifies how to distribute the worth of every network among the players. This allo

  13. Helically linked mirror arrangement

    International Nuclear Information System (INIS)

    A scheme is described for helical linking of mirror sections, which endeavors to combine the better features of toroidal and mirror devices by eliminating the longitudinal loss of mirror machines, having moderately high average β and steady state operation. This scheme is aimed at a device, with closed magnetic surfaces having rotational transform for equilibrium, one or more axisymmetric straight sections for reduced radial loss, a simple geometrical axis for the links and an overall positive magnetic well depth for stability. We start by describing several other attempts at linking of mirror sections, made both in the past and the present. Then a description of our helically linked mirror scheme is given. This example has three identical straight sections connected by three sections having helical geometric axes. A theoretical analysis of the magnetic field and single-particle orbits in them leads to the conclusion that most of the passing particles would be confined in the device and they would have orbits independent of pitch angle under certain conditions. Numerical results are presented, which agree well with the theoretical results as far as passing particle orbits are concerned

  14. Volumes of chain links

    CERN Document Server

    Kaiser, James; Rollins, Clint

    2011-01-01

    Agol has conjectured that minimally twisted n-chain links are the smallest volume hyperbolic manifolds with n cusps, for n at most 10. In his thesis, Venzke mentions that these cannot be smallest volume for n at least 11, but does not provide a proof. In this paper, we give a proof of Venzke's statement. The proof for n at least 60 is completely rigorous. The proof for n between 11 and 59 uses a computer calculation, and can be made rigorous for manifolds of small enough complexity, using methods of Moser and Milley. Finally, we prove that the n-chain link with 2m or 2m+1 half-twists cannot be the minimal volume hyperbolic manifold with n cusps, provided n is at least 60 or |m| is at least 8, and we give computational data indicating this remains true for smaller n and |m|.

  15. The Missing Link

    OpenAIRE

    Acs, Zoltan J.; Audretsch, David B.; Braunerhjelm, Pontus; Carlsson, Bo

    2005-01-01

    The intellectual breakthrough contributed by the new growth theory was the recognition that investments in knowledge and human capital endogenously generate economic growth through the spillover of knowledge. Endogenous growth theory does not explain how or why spillovers occur. The missing link is the mechanism converting knowledge into economically relevant knowledge. This paper develops a model that introduces a filter between knowledge and economic knowledge and identifies entrepreneurshi...

  16. WEAK LINKS AND DIVERSIFICATION

    OpenAIRE

    Cristian Ugarte

    2014-01-01

    An important literature has shown that the relationship between economic diversification and income per capita is non-monotonic (Imbs and Wacziarg, 2003 and Koren and Tenreyro, 2007). At early stages of development countries diversify as income increases and new economic opportunities emerge, but at later stages of development the production bundle becomes more concentrated as income rises. The aim of this paper is to explore the role played by Weak Links effects à la Jones (2011) in explaini...

  17. Meaning and Links

    OpenAIRE

    Woods, William A

    2007-01-01

    This article presents some fundamental ideas about representing knowledge and dealing with meaning in computer representations. I will describe the issues as I currently understand them and describe how they came about, how they fit together, what problems they solve, and some of the things that the resulting framework can do. The ideas apply not just to graph-structured "node-and-link" representations, sometimes called semantic networks, but also to representations referred to variously as f...

  18. Linking consumer experiences

    DEFF Research Database (Denmark)

    Smed, Karina Madsen

    become part of the individual self, worldview, and behaviour. This paper seeks to explore links between consumer experiences through the exploration of narrative sequences in travel blogs. Findings indicate that non-consumption is a central element to the bloggers and also indicative of a community......Consumers consume products in various ways serving a number of purposes. Much attention has been paid to experiences attached to consumption, sometimes very explicitly, e.g. in tourism, the essence of which is experiences of various sorts, but often also implicitly as internalised experiences...

  19. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... send the message to young people and to parents, teachers, and the media about the link between ... Send the message to young people and to parents, teachers, and the media about the link between ...

  20. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the Link - Drugs and HIV Learn the Link - Drugs and HIV Email Facebook Twitter 2005 –Ongoing Behaviors ... GA: CDC, DHHS. Retrieved June 2012 How are Drug Abuse and HIV Related? Drug abuse and addiction ...

  1. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... learn-link-drugs-hiv . 120x90 460x80 486x60 Social Media Send the message to young people and to parents, teachers, and the media about the link between drug abuse and HIV. ...

  2. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... NIDA Contact Us Sharing Tools and Badges Other Resources Strategic Plan Search Share Print Home » News & Events » Public Education Projects » Learn the Link - Drugs and HIV Learn the Link - ...

  3. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the link between drug abuse and HIV infection. It contains information for young people, parents and teachers, ... present time. The virus (HIV) and the disease it causes (AIDS) are often linked and referred to ...

  4. Link Analysis for Space Communication Links Using ARQ Protocol

    Science.gov (United States)

    Cheung, Kar-Ming; Lau, Chi-Wung; Lee, Charles

    2014-01-01

    In space communications, standard link analysis assumes that messages are sent once. For a communication link that uses an error-correction coding scheme, bit-error-rate (BER) or frame-error-rate (FER), and link margins are common metrics that characterize the quality of a link, and they are used to determine the supportable data rate. With the advent of Automatic Repeat-reQuest (ARQ) protocols, when messages are corrupted during transmission, they can be resent multiple times automatically until they are correctly received and acknowledged. The concept of BER, FER, and link margin cannot be directly applied, and the link analysis approach for ARQ links needs to be re-examined.

  5. Predicting missing links and identifying spurious links via likelihood analysis.

    Science.gov (United States)

    Pan, Liming; Zhou, Tao; Lü, Linyuan; Hu, Chin-Kun

    2016-01-01

    Real network data is often incomplete and noisy, where link prediction algorithms and spurious link identification algorithms can be applied. Thus far, it lacks a general method to transform network organizing mechanisms to link prediction algorithms. Here we use an algorithmic framework where a network's probability is calculated according to a predefined structural Hamiltonian that takes into account the network organizing principles, and a non-observed link is scored by the conditional probability of adding the link to the observed network. Extensive numerical simulations show that the proposed algorithm has remarkably higher accuracy than the state-of-the-art methods in uncovering missing links and identifying spurious links in many complex biological and social networks. Such method also finds applications in exploring the underlying network evolutionary mechanisms. PMID:26961965

  6. Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis

    Czech Academy of Sciences Publication Activity Database

    Machová, Iva; Snášel, Jan; Dostál, Jiří; Brynda, Jiří; Fanfrlík, Jindřich; Singh, M.; Tarábek, Ján; Vaněk, O.; Bednárová, Lucie; Pichová, Iva

    2015-01-01

    Roč. 10, č. 3 (2015), e0120682/1-e0120682/21. E-ISSN 1932-6203 R&D Projects: GA MŠk LO1302 EU Projects: European Commission(XE) 241587 - SYSTEMTB Institutional support: RVO:61388963 Keywords : crystal structure * noncovalent complexes * Mycobacterium tuberculosis * mechanism Subject RIV: CE - Biochemistry Impact factor: 3.234, year: 2014 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120682

  7. Linked Data: an Evolution

    Directory of Open Access Journals (Sweden)

    Karen Coyle

    2013-01-01

    Full Text Available Actually the world is full of hi-tech devices that allow in different ways to stay always connected and up-to-date. The high level of interactivity and interoperability is now a fundamental prerogative in the new millennium communication which no one can be exempted. In particular, librarian universe must reconfigure this new way to exchange and provide information otherwise it will cause the steady decline, and this will cause a huge loss of users who will find different ways to information: such as tablet or smartphone. The linked data can provide significant support for libraries to ensure that they can still be leaders in the future. A brief mention to the studies conducted in this domain.

  8. Using pLink to Analyze Cross-Linked Peptides.

    Science.gov (United States)

    Fan, Sheng-Bo; Meng, Jia-Ming; Lu, Shan; Zhang, Kun; Yang, Hao; Chi, Hao; Sun, Rui-Xiang; Dong, Meng-Qiu; He, Si-Min

    2015-01-01

    pLink is a search engine for high-throughput identification of cross-linked peptides from their tandem mass spectra, which is the data-analysis step in chemical cross-linking of proteins coupled with mass spectrometry analysis. pLink has accumulated more than 200 registered users from all over the world since its first release in 2012. After 2 years of continual development, a new version of pLink has been released, which is at least 40 times faster, more versatile, and more user-friendly. Also, the function of the new pLink has been expanded to identifying endogenous protein cross-linking sites such as disulfide bonds and SUMO (Small Ubiquitin-like MOdifier) modification sites. Integrated into the new version are two accessory tools: pLabel, to annotate spectra of cross-linked peptides for visual inspection and publication, and pConfig, to assist users in setting up search parameters. Here, we provide detailed guidance on running a database search for identification of protein cross-links using the 2014 version of pLink. PMID:25754995

  9. Linking to the Future

    Science.gov (United States)

    Moore, John W.

    1999-09-01

    of JCE in the mail each month, and I expect you do too. I can glance at the cover to get an overview of an issue's content, and I usually am enticed inside by intriguing cover art. I can scan the table of contents to find articles I want to read, or I can just browse through the issue to see what looks interesting. Usually the editors have juxtaposed related articles so that I often find a small treasure trove. The printed Journal is quite portable and can be read in a car or airplane. It will last a long time, and until the paper deteriorates, I will never have a problem reading back issues. I have almost every issue from the first day I subscribed and have even added some older ones from collections of retired colleagues who no longer had shelf space for them. I certainly would not want to give up my printed copies, and I want to keep getting them. I find that JCE Online provides a different kind of resource that is equally valuable. It contains more information, and information that is more appropriate in electronic form. It links related ideas into a much more complex web of information than is possible in print. And it opens pathways to lots of information that is not part of JCE but resides elsewhere. Using this issue as an example, let's take a tour of what JCE Online can do. Point your Web browser to http://jchemed.chem.wisc.edu Click on Journal and then on Current Issue (unless September 1999 is no longer the current issue, in which case you will find it in Past Issues). In the table of contents, find the article "UV Catalysis, Cyanotype Photography, and Sunscreens". Click on the title. When the abstract appears, click on Full Text (PDF) to see the article, just as it appears on page 1199 in this issue. When you are prompted, enter the name and subscriber number from your address label. At the end of the article you will find that supplementary materials are available (including a procedure for testing sunscreens) and you can click on the link to view them

  10. The CMS link system

    International Nuclear Information System (INIS)

    The Compact Muon Solenoid (CMS) is a multi-purpose detector that is going to be installed in the future Large Hadron Collider (LHC) at CERN. Muons are one of the main physical signatures of the expected new physics. The muons are going to be detected by the Central Tracker (CT) and the Muon Spectrometer (MS). Both, the CT and MS can provide an independent muon momentum measurement, but for all η and momentum values the highest precision for muon momentum measurement is achieved when the muon tracks are reconstructed using both tracking detectors. The calorimeters and the solenoid volumes separate about three meters the CT and the MS. It has been shown that the alignment of the CT with respect to the MS can not be guaranteed by a software alignment in a reasonable time scale. Therefore, an opto-mechanical system (the multipoint link system) have been designed to monitor, on-line, the relative position of both sub-detectors providing a common reference frame for both of them. The local alignment of the muon barrel spectrometer determines the relative position of the muon chambers with respect to themselves and also with respect to a carbon fiber rigid structure called MAB (Module for the Alignment of the Barrel). There are a total of 36 MABs distributed in the boundary planes of each muon spectrometer sector. This paper describes all the equipment and presents the principle of measurement. (author)

  11. Discovering link communities in complex networks by exploiting link dynamics

    International Nuclear Information System (INIS)

    Discovery of communities in complex networks is a fundamental data analysis problem with applications in various domains. Most of the existing approaches have focused on discovering communities of nodes, while recent studies have shown great advantages and utilities of the knowledge of communities of links in networks. From this new perspective, we propose a link dynamics based algorithm, called UELC, for identifying link communities of networks. In UELC, the stochastic process of a link–node–link random walk is employed to unfold an embedded bipartition structure of links in a network. The local mixing properties of the Markov chain underlying the random walk are then utilized to extract two emerging link communities. Further, the random walk and the bipartitioning processes are wrapped in an iterative subdivision strategy to recursively identify link partitions that segregate the network links into multiple subdivisions. We evaluate the performance of the new method on synthetic benchmarks and demonstrate its utility on real-world networks. Our experimental results show that our method is highly effective for discovering link communities in complex networks. As a comparison, we also extend UELC to extracting communities of nodes, and show that it is effective for node community identification. (paper)

  12. "Conjectural" links in complex networks

    OpenAIRE

    Snarskii, A. A.; Zorinets, D. I.; Lande, D. V.

    2016-01-01

    This paper introduces the concept of Conjectural Link for Complex Networks, in particular, social networks. Conjectural Link we understand as an implicit link, not available in the network, but supposed to be present, based on the characteristics of its topology. It is possible, for example, when in the formal description of the network some connections are skipped due to errors, deliberately hidden or withdrawn (e.g. in the case of partial destruction of the network). Introduced a parameter ...

  13. Relational link-based ranking

    OpenAIRE

    Geerts, Floris; Mannila, Heikki; Terzi, Evimaria

    2004-01-01

    Link analysis methods show that the interconnections between web pages have lots of valuable information. The link analysis methods are, however, inherently oriented towards analyzing binary relations. We consider the question of generalizing link analysis methods for analyzing relational databases. To this aim, we provide a generalized ranking framework and address its practical implications. More specifically, we associate with each relational database and set of queries a unique weig...

  14. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available Researchers Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr ...

  15. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs ... HIV Learn the Link - Drugs and HIV Email Facebook Twitter 2005 –Ongoing Behaviors associated with drug abuse ...

  16. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Strategic Plan Search Share Print Home » News & Events » Public Education Projects » Learn the Link - Drugs and HIV Learn the Link - Drugs and HIV Email Facebook Twitter 2005 –Ongoing Behaviors associated with drug abuse are among the main ...

  17. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs of Abuse Commonly Abused Drugs Charts Emerging ... Badges Other Resources Strategic Plan Search Share Print Home » News & Events » Public Education Projects » Learn the Link - ...

  18. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the link between drug abuse and HIV/AIDS, populations most at risk, trends in HIV/AIDS, and ... increasingly at risk for HIV infection through risky sexual behaviors. NIDA researchers have studied and continue to study the links between drug abuse and HIV/AIDS. In the early years of ...

  19. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... transmitting HIV/AIDS or other infectious diseases. Research Reports: HIV/AIDS : Explores the link between drug abuse ... at: https://www.drugabuse.gov/news-events/public-education-projects/learn-link-drugs-hiv . 120x90 460x80 486x60 ...

  20. Decouplink: Dynamic Links for Java

    DEFF Research Database (Denmark)

    Jensen, Martin Lykke Rytter; Jørgensen, Bo Nørregaard

    2011-01-01

    of dimensions of extension that can be exploited without performing modification of existing types. Thus, dynamic links make it possible to enforce the open/closed principle in situations where it would otherwise not be possible. We present Decouplink – a library-based implementation of dynamic links for Java...

  1. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the Link campaign. This campaign shows teens and young adults that non-injection drug use and alcohol use can lead to poor decision making, which ... send the message to America's youth that using drugs and alcohol even once ... in the lives of young people-with the Learn the Link message. Campaign ...

  2. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the message to young people and to parents, teachers, and the media about the link between drug abuse and HIV. We have produced a set of ... the message to young people and to parents, teachers, and the media about the link between drug abuse and HIV. Post on Facebook or Twitter ; add ...

  3. Drugs + HIV, Learn the Link

    Science.gov (United States)

    ... the message to young people and to parents, teachers, and the media about the link between drug abuse and HIV. We have produced a set of ... the message to young people and to parents, teachers, and the media about the link between drug abuse and HIV. Post on Facebook or Twitter ; add ...

  4. [Sex-linked juvenile retinoschisis].

    Science.gov (United States)

    François, P; Turut, P; Soltysik, C; Hache, J C

    1976-02-01

    About 13 observations of sexe linked juvenile retinoschisis, the authors describe the ophthalmoscopic, fluorographic and functional aspects of the disease whose caracteristics are:--its sexe linked recessive heredity; --its clinical characterestics associating: a microcystic macular degeneration, peripheral retinal lesions, vitreous body alterations, --an electroretinogram of the negative type. PMID:132916

  5. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Plan Search Share Print Home » News & Events » Public Education Projects » Learn the Link - Drugs and HIV Learn the Link - Drugs and HIV Email Facebook Twitter 2005 –Ongoing Behaviors associated with drug abuse are among the main factors in the spread of HIV infection in the ...

  6. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Learn the Link campaign uses TV, print, and Web public service announcements (PSAs), as well as posters, e-cards, ... to use drugs. The Learn the Link public service campaign is just one ... this Web site. Sincerely, Nora D. Volkow, M.D. Director ...

  7. Interpreting Linked Psychomotor Performance Scores

    Science.gov (United States)

    Looney, Marilyn A.

    2013-01-01

    Given that equating/linking applications are now appearing in kinesiology literature, this article provides an overview of the different types of linked test scores: equated, concordant, and predicted. It also addresses the different types of evidence required to determine whether the scores from two different field tests (measuring the same…

  8. The Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows.

    Science.gov (United States)

    White, Heather M

    2015-01-01

    The transition to lactation period in dairy cattle is characterized by metabolic challenges, negative energy balance, and adipose tissue mobilization. Metabolism of mobilized adipose tissue is part of the adaptive response to negative energy balance in dairy cattle; however, the capacity of the liver to completely oxidize nonesterified fatty acids may be limited and is reflective of oxaloacetate pool, the carbon carrier of the tricarboxylic acid cycle. Alternative metabolic fates of acetyl-CoA from nonesterified fatty acids include esterification to triacylglycerides and ketogenesis, and when excessive, these pathways lead to fatty liver and ketosis. Examination of the anaplerotic and cataplerotic pull of oxaloacetate by the tricarboxylic acid cycle and gluconeogenesis may provide insight into the balance of oxidation and esterification of acetyl-CoA within the liver of periparturient dairy cows. PMID:26479386

  9. The Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows

    Directory of Open Access Journals (Sweden)

    Heather M. White

    2015-08-01

    Full Text Available The transition to lactation period in dairy cattle is characterized by metabolic challenges, negative energy balance, and adipose tissue mobilization. Metabolism of mobilized adipose tissue is part of the adaptive response to negative energy balance in dairy cattle; however, the capacity of the liver to completely oxidize nonesterified fatty acids may be limited and is reflective of oxaloacetate pool, the carbon carrier of the tricarboxylic acid cycle. Alternative metabolic fates of acetyl-CoA from nonesterified fatty acids include esterification to triacylglycerides and ketogenesis, and when excessive, these pathways lead to fatty liver and ketosis. Examination of the anaplerotic and cataplerotic pull of oxaloacetate by the tricarboxylic acid cycle and gluconeogenesis may provide insight into the balance of oxidation and esterification of acetyl-CoA within the liver of periparturient dairy cows.

  10. Sex linked deafness: Wilde revisited.

    OpenAIRE

    Reardon, W

    1990-01-01

    Sex linked recessive deafness is a rare cause of male genetic deafness, estimated to account for 6.2% of male genetic deafness in 1966. A male excess was found in the deaf population of Ireland in 1851. Reevaluation of this survey of 1851 confirms sex linked deafness as a factor in the disproportionate number of deaf males and suggests that 5% of congenital male deafness was the result of sex linked recessive deafness. This study confirms that a small but constant proportion of male deafness ...

  11. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Abuse, Dr. Nora D. Volkow. Message from the Director The Link Between HIV/AIDS and Drug Abuse ... Web site. Sincerely, Nora D. Volkow, M.D. Director National Institute on Drug Abuse Collaborators Thanks to ...

  12. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... about the link between drug abuse and HIV. We have produced a set of multicultural public service ... many of us think about HIV/AIDS when we’re at parties or hanging out with friends? ...

  13. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available Researchers Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs of Abuse Commonly Abused ...

  14. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... patients who do not abuse drugs. In animal studies, methamphetamine has been shown to increase the amount ... behaviors. NIDA researchers have studied and continue to study the links between drug abuse and HIV/AIDS. ...

  15. Drugs + HIV, Learn the Link

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    Full Text Available ... affect anyone. Watch the “d’cisions” Videos Campaign Materials After the Party Posters: We have developed posters ... the Learn the Link message. Campaign messages and materials were tested among various groups of young people, ...

  16. Drugs + HIV, Learn the Link

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    Full Text Available ... Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs ...

  17. Drugs + HIV, Learn the Link

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    Full Text Available ... on our website that are available for your use to share on your social media accounts. About the Campaign Overview The Learn the Link campaign uses TV, print, and Web public service announcements (PSAs), ...

  18. Drugs + HIV, Learn the Link

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    Full Text Available ... Drugs and HIV Learn the Link - Drugs and HIV Email Facebook Twitter 2005 –Ongoing Behaviors associated with ... Send the Message . Get the Facts What are HIV and AIDS? HIV (human immunodeficiency virus) is the ...

  19. Drugs + HIV, Learn the Link

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    Full Text Available ... HIV (human immunodeficiency virus) is the virus that causes AIDS (acquired immune deficiency syndrome). AIDS is a ... time. The virus (HIV) and the disease it causes (AIDS) are often linked and referred to as " ...

  20. Drugs + HIV, Learn the Link

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    Full Text Available ... Addiction Science Adolescent Brain Comorbidity College-Age & Young Adults Criminal Justice Drugged Driving Drug Testing Drugs and ... Link campaign. This campaign shows teens and young adults that non-injection drug use and alcohol use ...

  1. Drugs + HIV, Learn the Link

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    Full Text Available ... young people engage in risk-taking and sensation-seeking behaviors. Unsafe sexual practices increase a person's risk ... easily copy and paste to help show your support for Learn the Link . Be sure to check ...

  2. Drugs + HIV, Learn the Link

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    Full Text Available ... posters with ad copy. You can print and display the posters. Tagline Only (PDF, 1.2MB) Ad ... ads that you can download and add to your Web site. Please link these banners back to ...

  3. Drugs + HIV, Learn the Link

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    Full Text Available ... other organizations in your tweets to spread the word even further. Tweet About Learn the Link To ... other organizations in your tweets to spread the word even further. Share with Flickr, Pinterest or Instagram ...

  4. Drugs + HIV, Learn the Link

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    Full Text Available ... through 15 (as well as their parents and teachers). It provides them with useful information on the ... the message to young people and to parents, teachers, and the media about the link between drug ...

  5. Drugs + HIV, Learn the Link

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    Full Text Available ... for your use to share on your social media accounts. About the Campaign Overview The Learn the Link campaign uses TV, print, and Web public service announcements (PSAs), as ...

  6. Drugs + HIV, Learn the Link

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    Full Text Available ... abuse and HIV infection. It contains information for young people, parents and teachers, and the media with links ... 177(1):355-361. How are Teens Affected? Young people are at risk for contracting HIV. In general, ...

  7. Drugs + HIV, Learn the Link

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    Full Text Available ... teens and young adults have never known a world without it. NIDA’s "Learn the Link" campaign continues ... the treatment regimen and realizing beneficial outcomes. NIDA research has shown this to be true for people ...

  8. Drugs + HIV, Learn the Link

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    Full Text Available ... transmitting HIV/AIDS or other infectious diseases. Research Reports: HIV/AIDS : Explores the link between drug abuse ... access to the latest, federally approved HIV/AIDS medical practice guidelines, HIV treatment and prevention clinical trials, ...

  9. Drugs + HIV, Learn the Link

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    Full Text Available ... NIDA’s "Learn the Link" campaign continues to raise awareness among this generation of the real risks of ... Collaborators Thanks to Those Who Have Helped Raise Awareness of Our Campaign! NIDA acknowledges the following television ...

  10. Drugs + HIV, Learn the Link

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    Full Text Available ... causes AIDS (acquired immune deficiency syndrome). AIDS is a disease of the immune system for which there ... causes (AIDS) are often linked and referred to as "HIV/AIDS." HIV can be transferred between people ...

  11. Drugs + HIV, Learn the Link

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    Full Text Available ... AIDS (acquired immune deficiency syndrome). AIDS is a disease of the immune system for which there is ... the present time. The virus (HIV) and the disease it causes (AIDS) are often linked and referred ...

  12. Drugs + HIV, Learn the Link

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    Full Text Available ... consequences. We also work to reach parents and teachers-influential figures in the lives of young people-with the Learn the Link message. Campaign messages and materials were ...

  13. Drugs + HIV, Learn the Link

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    Full Text Available ... Link between drug abuse and HIV and to help us Send the Message . Get the Facts What ... still be aired. Send the Message Overview Please help us send the message to young people and ...

  14. Drugs + HIV, Learn the Link

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    Full Text Available ... Web banner ads that you can download and add to your Web site. Please link these banners ... abuse and HIV. Post on Facebook or Twitter ; add photos to your Flickr , Pinterest , and Instagram pages; ...

  15. Drugs + HIV, Learn the Link

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    Full Text Available ... teens and young adults have never known a world without it. NIDA’s "Learn the Link" campaign continues to raise awareness among this generation of the real risks of drug use for transmitting HIV, and ...

  16. Drugs + HIV, Learn the Link

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    Full Text Available ... June 2012 How are Drug Abuse and HIV Related? Drug abuse and addiction have been linked with ... treatment stop or reduce their drug use and related risk behaviors, including drug injection and unsafe sexual ...

  17. Drugs + HIV, Learn the Link

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    Full Text Available ... educational institutions, magazines, newspapers, companies, events, and radio stations for helping to raise awareness of the link ... Poets Sistahs Getting Real About HIV Conference Radio Stations: WTOP Radio WPFW Radio WOL Radio News & Events ...

  18. Protein Linked to Atopic Dermatitis

    Science.gov (United States)

    ... Research Matters NIH Research Matters January 14, 2013 Protein Linked to Atopic Dermatitis Normal skin from a ... in mice suggests that lack of a certain protein may trigger atopic dermatitis, the most common type ...

  19. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available Researchers Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs of Abuse ...

  20. Medicare and Medicaid Linked Files

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Medicare-Medicaid Linked Enrollee Analytic Data Source (MMLEADS) has been developed to allow for the examination of all Medicare and Medicaid enrollment and...

  1. Drugs + HIV, Learn the Link

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    Full Text Available ... pictures from NIDA images. Visit the NIDA Flickr account for images Share your favorite image! Check out ... your use to share on your social media accounts. About the Campaign Overview The Learn the Link ...

  2. Effect of gastric bypass surgery on mRNA expression level of hepatic phosphoenolpyruvate carboxykinase in type 2 diabetic Goto-Kakizaki rats%胃旁路术对2型糖尿病大鼠肝脏磷酸烯醇式丙酮酸羧激酶mRNA表达的影响

    Institute of Scientific and Technical Information of China (English)

    谢杰斌; 蔡景理; 李立军; 张林君; 姜明哲; 陈登刚; 陈荣

    2012-01-01

    Objective To investigate the effects of gastric bypass surgery(GBP)on hepatic phosphoenolpyruvate carboxykinase(PEPCK)mRNA expression in type 2 diabetic Goto-Kakizaki rats.Methods Male GK rats were randomized into three groups:gastric bypass surgery(n=10),sham operation with diet restriction(n=10),and sham operation alone(n=10).Liver specimens of GK rats were collected during the intraoperative period for self-control study and 8 weeks after surgery.Fasting blood glucose,food intake,and body weight were recorded before surgery and 1,2,4,8 weeks after surgery.The expression of PEPCK mRNA was measured by real-time PCR.Results The fasting plasma glucose level decreased from(17.6±2.1)mmol/L before surgery to(7.5±0.9)mmol/L 8 weeks after surgery in GBP group.The level of PEPCK mRNA decreased from 1.08±0.38 before surgery to 0.41±0.10 8 weeks after surgery,significantly lower than that in sham operation alone group(1.04±0.12)(P<0.01).The level of PEPCK mRNA in diet restriction group increased from 1.15±0.16 before surgery to 2.54±0.82 8 weeks after surgery(P<0.01).The expression of PEPCK mRNA in diet restriction was significantly higher than that in CBP group(P<0.01).Conclusions GBP can significantly improve hyperglycemia in type 2 diabetic GK rat models,which may be associated with the decrease of hepatic PEPCK mRNA level.%目的 研究胃旁路术对2型糖尿病Goto-Kakizaki(GK)大鼠降糖作用及肝脏磷酸烯醇式丙酮酸羧激酶(PEPCK)mRNA表达的影响.方法 将30只12周龄的雄性GK大鼠分为手术组(胃旁路术,10只)、假手术饮食控制组(10只)及假手术空白对照组(10只),术中取各组肝脏标本用于术后对照研究.观察手术前后空腹血糖、进食量及体质量变化情况.术后8周取各组肝脏标本,用实时荧光定量PCR(real-time PCR)检测各组肝脏手术前后PEPCK mRNA的表达变化.结果 术后8周,手术组空腹血糖由术前(17.6±2.1)mmol/L下降至(7.5±0.9)mmol

  3. Linking Ethics and Economic Growth

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul

    2012-01-01

    Hunt (2012) builds on his work concerning ethics and resource-advantage theory to link personal ethical standards, societal norms, and economic growth but offers few details concerning the precise mechanisms that link ethics and growth. This comment suggests a number of such mechanisms – for...... example, the influence of prevailing ethical norms on the aggregate elasticity of substitution and, therefore, total factor productivity and growth....

  4. Linking water and permafrost dynamics

    OpenAIRE

    Sjöberg, Ylva

    2015-01-01

    The extent and dynamics of permafrost are tightly linked to the distribution and movement of water in arctic landscapes. As the Arctic warms more rapidly than the global average, profound changes are expected in both permafrost and hydrology; however, much is still not known about the interactions between these two systems. The aim of this thesis is to provide new knowledge on the links between permafrost and hydrology under varying environmental conditions and across different scales. The ob...

  5. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Be sure to check out the NIDA Facebook page and tag us in your posts! Learn the link between drug abuse and HIV. http://1.usa.gov/1z20ww6 How many of us think about HIV/AIDS when we’re at parties or hanging out with friends? It’s a topic you can’t ignore. Learn the Link: http:// ...

  6. Manual de LinkedIn

    OpenAIRE

    Blazquez, Alegría; Oriol BORRÁS GENÉ

    2016-01-01

    Manual básico sobre la red profesional LinkedIn, donde se analiza la red y se explica a fondo cómo crear un perfil y gestionarlo. Incluye información sobre las diferentes secciones características de la red LinkedIn y ofrece consejos para la correcta gestión de un perfil, buscando su mejor rendimiento.

  7. Communication through a quantum link

    OpenAIRE

    Giovannetti V.; Burgarth D.; Mancini S.

    2009-01-01

    A chain of interacting spin behaves like a quantum mediator (quantum link) which allows two distant parties that control the ends of the chain to exchange quantum messages. We show that over repeated uses without resetting the study of a quantum link can be connected to correlated quantum channels with finite dimensional environment (finite memory quantum channel). Then, using coding arguments for such kind of channels and results on mixing channels we present a protocol that allows us to ach...

  8. Linked data and user interaction

    CERN Document Server

    Cervone, H Frank

    2015-01-01

    This collection of research papers provides extensive information on deploying services, concepts, and approaches for using open linked data from libraries and other cultural heritage institutions. With a special emphasis on how libraries and other cultural heritage institutions can create effective end user interfaces using open, linked data or other datasets. These papers are essential reading for any one interesting in user interface design or the semantic web.

  9. LinkMind: Link Optimization in Swarming Mobile Sensor Networks

    Directory of Open Access Journals (Sweden)

    Trung Dung Ngo

    2011-08-01

    Full Text Available A swarming mobile sensor network is comprised of a swarm of wirelessly connected mobile robots equipped with various sensors. Such a network can be applied in an uncertain environment for services such as cooperative navigation and exploration, object identification and information gathering. One of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximize the transmission of gathered data from a source to a target. This paper describes a new method of link optimization of swarming mobile sensor networks. The new method is based on combination of the artificial potential force guaranteeing connectivities of the mobile sensor nodes and the max-flow min-cut theorem of graph theory ensuring optimization of the network link capacity. The developed algorithm is demonstrated and evaluated in simulation.

  10. LinkMind: Link Optimization in Swarming Mobile Sensor Networks

    DEFF Research Database (Denmark)

    Ngo, Trung Dung

    2012-01-01

    A swarming mobile sensor network is comprised of a swarm of wirelessly connected mobile robots equipped with various sensors. Such a network can be applied in an uncertain environment for services such as cooperative navigation and exploration, object identification and information gathering. One...... of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximize the transmission of gathered data from a source to a target. This paper describes a new method of link...... optimization of swarming mobile sensor networks. The new method is based on combination of the artificial potential force guaranteeing connectivities of the mobile sensor nodes and the max-flow min-cut theorem of graph theory ensuring optimization of the network link capacity. The developed algorithm...

  11. LinkMind: link optimization in swarming mobile sensor networks.

    Science.gov (United States)

    Ngo, Trung Dung

    2011-01-01

    A swarming mobile sensor network is comprised of a swarm of wirelessly connected mobile robots equipped with various sensors. Such a network can be applied in an uncertain environment for services such as cooperative navigation and exploration, object identification and information gathering. One of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximize the transmission of gathered data from a source to a target. This paper describes a new method of link optimization of swarming mobile sensor networks. The new method is based on combination of the artificial potential force guaranteeing connectivities of the mobile sensor nodes and the max-flow min-cut theorem of graph theory ensuring optimization of the network link capacity. The developed algorithm is demonstrated and evaluated in simulation. PMID:22164070

  12. SetLink the CERN Document Server Link Manager

    CERN Document Server

    Le Meur, Jean-Yves

    2000-01-01

    This paper analyses the problems encountered by electronic libraries to cope with long term keeping of on-line documents. What is thebest solution not to fill in a library system with non persistent addresses ? Different possible solutions are studied, based on theexperience of the CERN Document Server and its library. This paper will stress the importance of using a Link Manager for any long term Web server. It will explain how the CERN SetLink Link Manager is designed to handle a wide range of document types and formats, from photos in JPEG to eprints in PDF. It will also focus onother possibilities offered by using such an application, like automatic figures extraction or concatenation, full text searching andon-the-fly format conversions.

  13. Seismic link at plate boundary

    Indian Academy of Sciences (India)

    Faical Ramdani; Omar Kettani; Benaissa Tadili

    2015-06-01

    Seismic triggering at plate boundaries has a very complex nature that includes seismic events at varying distances. The spatial orientation of triggering cannot be reduced to sequences from the main shocks. Seismic waves propagate at all times in all directions, particularly in highly active zones. No direct evidence can be obtained regarding which earthquakes trigger the shocks. The first approach is to determine the potential linked zones where triggering may occur. The second step is to determine the causality between the events and their triggered shocks. The spatial orientation of the links between events is established from pre-ordered networks and the adapted dependence of the spatio-temporal occurrence of earthquakes. Based on a coefficient of synchronous seismic activity to grid couples, we derive a network link by each threshold. The links of high thresholds are tested using the coherence of time series to determine the causality and related orientation. The resulting link orientations at the plate boundary conditions indicate that causal triggering seems to be localized along a major fault, as a stress transfer between two major faults, and parallel to the geothermal area extension.

  14. Deformation of Linked Polymer Coils

    Institute of Scientific and Technical Information of China (English)

    董朝霞; 李明远; 吴肇亮; 林梅钦

    2003-01-01

    Linked polymer solution (LPS) is defined as the solution of linked polymer coils (LPCs) dispersed in water, composed of low concentration partially hydrolyzed polyacrylamide (HPAM) and aluminum citrate (crosslinker). In the work, the conformational changes of LPCs under different conditions were investigated by the methods of membrane filtering under low pressure, dynamic light scattering and core flooding experiments. The results showed that in some conditions the LPCs could be compressed mechanically to 1/158.5 of their original volume because of relatively lower HPAM cross-linking. The hydration property of LPCs was similar to that of normal polymer coils. The deformation of LPCs was more restricted than that of ordinary polymer coils under the flow shear stress or the shift of hydration equilibrium caused in the variation of the electrolyte concentration which is responsible for the effective plugging in the throats of porous media when LPCs are used for deep diverting.

  15. On ω-Linked Overrings

    Institute of Scientific and Technical Information of China (English)

    Lin XIE; Fang Gui WANG; Yan TIAN

    2011-01-01

    Let R (C) T be an extension of commutative rings. T is called ω-linked over R if T as an R-module is a ω-module. In the case of R (C) T (C) Q0(R), T is called a ω-linked overring of R. As a generalization of Wang-McCsland-Park-Chang Theorem, we show that if R is a reduced ring, then R is a ω-Noetherian ring with ω-dim(R) ≤1 if and only if each ω-linked overring T of R is a ω-Noetherian ring with ω-dim(T) ≤ 1. In particular, R is a ω-Noetherian ring with ω-dim(R) = 0 if and only if R is an Artinian ring.

  16. Link Prediction via Matrix Completion

    CERN Document Server

    Pech, Ratha; Pan, Liming; Cheng, Hong; Zhou, Tao

    2016-01-01

    Inspired by practical importance of social networks, economic networks, biological networks and so on, studies on large and complex networks have attracted a surge of attentions in the recent years. Link prediction is a fundamental issue to understand the mechanisms by which new links are added to the networks. We introduce the method of robust principal component analysis (robust PCA) into link prediction, and estimate the missing entries of the adjacency matrix. On one hand, our algorithm is based on the sparsity and low rank property of the matrix, on the other hand, it also performs very well when the network is dense. This is because a relatively dense real network is also sparse in comparison to the complete graph. According to extensive experiments on real networks from disparate fields, when the target network is connected and sufficiently dense, whatever it is weighted or unweighted, our method is demonstrated to be very effective and with prediction accuracy being considerably improved comparing wit...

  17. The ALICE detector data link

    CERN Document Server

    Rubin, G; Csató, P; Dénes, E; Kiss, T; Meggyesi, Z; Sulyán, J; Vesztergombi, G; Eged, B; Gerencsér, I; Novák, I; Soós, C; Tarján, D; Telegdy, A; Tóth, N

    1999-01-01

    The ALICE detector data link has been designed to cover all the needs for data transfer between the detector and the data-acquisition system. It is a 1 Gbit/s, full-duplex, multi-purpose fibre optic link that can be used as a medium for the bi-directional transmission of data blocks between the front-end electronics and the data- acquisition system and also for the remote control and test of the front-end electronics, In this paper the concept, the protocol, the specific test tools, the prototypes of the detector data link and the read-out receiver card, their application in the ALICE-TPC test system and the integration with the DATE software are presented. The test results on the performance are also shown. (14 refs).

  18. Crosscap Numbers of Two-component Links

    OpenAIRE

    Zhang, Gengyu

    2006-01-01

    We define the crosscap number of a 2-component link as the minimum of the first Betti numbers of connected, non-orientable surfaces bounding the link. We discuss some properties of the crosscap numbers of 2-component links.

  19. When He Said Linking, He Really Meant Linking

    Science.gov (United States)

    Chudnov, Daniel

    2009-01-01

    There are many reasons to improve web links, starting with their design. The author tends to think about "design" on the web in terms of two things: (1) graphic/industrial design; and (2) human usability. A nice, clean URI (uniform resource identifier) that does not change, is readable to humans, is amenable to common web behaviors such as…

  20. Interfacial Bioorthogonal Cross-Linking

    OpenAIRE

    Zhang, Han; Dicker, Kevin T.; Xu, Xian; Jia, Xinqiao; Fox, Joseph M.

    2014-01-01

    Described herein is interfacial bioorthogonal cross-linking, the use of bioorthogonal chemistry to create and pattern biomaterials through diffusion-controlled gelation at the liquid-gel interface. The basis is a rapid (k 2 284000 M–1 s–1) reaction between strained trans-cyclooctene (TCO) and tetrazine (Tz) derivatives. Syringe delivery of Tz-functionalized hyaluronic acid (HA-Tz) to a bath of bis-TCO cross-linker instantly creates microspheres with a cross-linked shell through which bis-TCO ...

  1. Linking Education to the Economy.

    Science.gov (United States)

    Neuschel, Robert P.; And Others

    The papers in this section of the proceedings of the 1981 World Assembly of the International Council on Education for Teaching concern educational reforms and how they can address national economic needs. An introductory article by Robert P. Neuschel, "Linking Education to the Economy: An Introductory Statement," discusses the relationship that…

  2. Tweaking Synchronisation by Link Addition

    CERN Document Server

    Schultz, Paul; Eroglu, Deniz; Stemler, Thomas; Ávila, G Marcelo Ramírez; Rodrigues, Francisco A; Kurths, Jürgen

    2016-01-01

    Natural and man-made networks often possess locally tree-like sub-structures. Taking such tree networks as our starting point, we show how the addition of links changes the synchronization properties of the network. We focus on two different methods of link addition. The first method adds single links that create cycles of a well-defined length. Following a topological approach we introduce cycles of varying length and analyze how this feature, as well as the position in the network, alters the synchronous behaviour. We show that in particular short cycles can lead to a maximum change of the Laplacian's eigenvalue spectrum, dictating the synchronization properties of such networks. The second method connects a certain proportion of the initially unconnected nodes. We simulate dynamical systems on these network topologies, with the nodes' local dynamics being either a discrete or continuous. Here our main result is that a certain amount of additional links, with the relative position in the network being cruci...

  3. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available Researchers Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs of Abuse Commonly Abused Drugs Charts Emerging Trends and Alerts Alcohol Club ...

  4. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... About NIDA Director's Page Organization Legislative Activities Advisory Boards & Groups Working at NIDA Donating to NIDA Contact Us Sharing Tools and Badges Other Resources Strategic Plan Search Share Print Home » News & Events » Public Education Projects » Learn the Link - Drugs and HIV Learn ...

  5. X-linked Alport syndrome

    DEFF Research Database (Denmark)

    Jais, J P; Knebelmann, B; Giatras, I;

    2000-01-01

    Alport syndrome (AS) is a type IV collagen hereditary disease characterized by the association of progressive hematuric nephritis, hearing loss, and, frequently, ocular changes. Mutations in the COL4A5 collagen gene are responsible for the more common X-linked dominant form of the disease. Consid...

  6. X-linked Alport syndrome

    DEFF Research Database (Denmark)

    Jais, Jean Philippe; Knebelmann, Bertrand; Giatras, Iannis;

    2003-01-01

    Alport syndrome (AS) is a type IV collagen hereditary disease characterized by progressive hematuric nephritis, hearing loss, and ocular changes. Mutations in the COL4A5 collagen gene are responsible for the more common X-linked dominant form of the disease characterized by much less severe disea...

  7. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Send the Message . Get the Facts What are HIV and AIDS? HIV (human immunodeficiency virus) is the virus that ... AIDS) are often linked and referred to as "HIV/AIDS." HIV can be transferred between people if an ...

  8. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... News NIDA Notes Podcasts E-Newsletters Public Education Projects Contact the Press Office Meetings & Events Media Guide ... Search Share Print Home » News & Events » Public Education Projects » Learn the Link - Drugs and HIV Learn the ...

  9. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter ... Sharing Tools and Badges Other Resources Strategic Plan Search Share Print Home » News & Events » Public Education Projects » ...

  10. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... projects/learn-link-drugs-hiv . 120x90 460x80 486x60 Social Media Send the message to young people and ... the discussion between friends, and the importance of family. For more information, read a message from the ...

  11. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... CDC, DHHS. Retrieved June 2012 How are Drug Abuse and HIV Related? Drug abuse and addiction have been linked with HIV/AIDS ... this regard, the role that non-injection drug abuse plays in the spread of HIV is less ...

  12. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... projects/learn-link-drugs-hiv . 120x90 460x80 486x60 Social Media Send the message to young people and to ... available for your use to share on your social media accounts. About the Campaign Overview The Learn the ...

  13. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the News NIDA Notes Podcasts E-Newsletters Public Education Projects Contact the Press Office Meetings & Events Media ... Plan Search Share Print Home » News & Events » Public Education Projects » Learn the Link - Drugs and HIV Learn ...

  14. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... projects/learn-link-drugs-hiv . 120x90 460x80 486x60 Social Media Send the message to young people and ... Center (NWHRC) Mujeres Unidas Contra el SIDA New Mexico AIDS Services African Advocates Against AIDS The Women’s ...

  15. The Øresund Link

    DEFF Research Database (Denmark)

    Møller, Jacob Steen

    "Øresundsbron" is the combined bridge and tunnel connecting Denmark and Sweden adjacent to Copenhagen. Øresundsbron was built and is operated by a consortium owned jointly by the Danish and Swedish states. The Link was inaugurated 1 July 2000 by the Queen of Denmark and the King of Sweden. The 16...

  16. Time transfer using fiber links

    Czech Academy of Sciences Publication Activity Database

    Smotlacha, V.; Kuna, Alexander; Mache, W.

    New York: IEE, 2010, s. 6533650. ISBN 978-1-4673-5970-2. [24th European Frequency and Time Forum, EFTF 2010. Noordwijk (NL), 13.04.2010-16.10.2010] Institutional research plan: CEZ:AV0Z20670512 Keywords : calibration * fiber link * optical network Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  17. What Is Linked Historical Data?

    NARCIS (Netherlands)

    Meroño-Peñuela, Albert; Hoekstra, Rinke; Janowicz, Krzysztof; Schlobach, Stefan; Lambrix, Patrick; Hyvönen, Eero

    2014-01-01

    Datasets that represent historical sources are relative new- comers in the Linked Open Data (LOD) cloud. Following the standard LOD practices for publishing historical sources raises several questions: how can we distinguish between RDF graphs of primary and secondary sources? Should we treat archiv

  18. What is Linked Historical Data?

    NARCIS (Netherlands)

    A. Meroño-Peñuela; R. Hoekstra

    2014-01-01

    Datasets that represent historical sources are relative newcomers in the Linked Open Data (LOD) cloud. Following the standard LOD practices for publishing historical sources raises several questions: how can we distinguish between RDF graphs of primary and secondary sources? Should we treat archived

  19. LCSH, SKOS and Linked Data

    CERN Document Server

    Summers, Ed; Redding, Clay; Krech, Dan

    2008-01-01

    A technique for converting Library of Congress Subject Headings MARCXML to Simple Knowledge Organization System (SKOS) RDF is described. Strengths of the SKOS vocabulary are highlighted, as well as possible points for extension, and the integration of other semantic web vocabularies such as Dublin Core. An application for making the vocabulary available as linked-data on the Web is also described.

  20. Links between metabolism and cancer

    OpenAIRE

    Dang, Chi V.

    2012-01-01

    Excessive caloric intake is associated with increased risk for cancer, while the nonobese state may be protective through mechanisms that reduce oxidative stress. In this review, Dang discusses the links between metabolism and cancer, which range from the low incidence of cancer in large mammals with low specific metabolic rates to altered cancer cell metabolism resulting from mutated enzymes or cancer genes.

  1. Linking integration and residential segregation

    NARCIS (Netherlands)

    Bolt, G.S.; Özüekren, A.S.; Phillips, Deborah

    2010-01-01

    In the introduction to this special issue of JEMS, we question the strong link which is often made between the integration of minority ethnic groups and their residential segregation. In the literature on neighbourhood effects, the residential concentration of minorities is seen as a major obstacle

  2. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... with HIV is a key predictor of the development of AIDS. Because of their compromised immune system, ... at: https://www.drugabuse.gov/news-events/public-education-projects/learn-link-drugs-hiv . 120x90 460x80 486x60 ...

  3. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... send the message to young people and to parents, teachers, and the media about the link between drug abuse and HIV. We have produced a set of multicultural public service announcements (PSAs) that use text messaging as a means of communication. The "Text Message" PSA features two young girls ...

  4. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available Researchers Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter ... Brain Genetics Global Health Hepatitis (Viral) HIV/AIDS Medical Consequences Mental Health Military Pain Prevention Treatment Trends & ...

  5. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Adolescent Brain Comorbidity College-Age & Young Adults Criminal Justice Drugged Driving Drug Testing Drugs and the Brain ... projects/learn-link-drugs-hiv . 120x90 460x80 486x60 Social Media Send the message to young people and ...

  6. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... projects/learn-link-drugs-hiv . 120x90 460x80 486x60 Social Media Send the message to young people and ... available for your use to share on your social media accounts. About the Campaign Overview The Learn ...

  7. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... young people and to parents, teachers, and the media about the link between drug abuse and HIV. We have produced a set of multicultural public service announcements (PSAs) that use text messaging as a means of communication. The "Text Message" PSA features two young girls ...

  8. LinkMind: Link Optimization in Swarming Mobile Sensor Networks

    OpenAIRE

    Trung Dung Ngo

    2011-01-01

    A swarming mobile sensor network is comprised of a swarm of wirelessly connected mobile robots equipped with various sensors. Such a network can be applied in an uncertain environment for services such as cooperative navigation and exploration, object identification and information gathering. One of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximiz...

  9. On the computation of torus link homology

    OpenAIRE

    Elias, Ben; Hogancamp, Matthew

    2016-01-01

    We introduce a new method for computing triply graded link homology, which is particularly well-adapted to torus links. Our main application is to the (n,n)-torus links, for which we give an exact answer for all n. In several cases, our computations verify conjectures of Gorsky et al relating homology of torus links with Hilbert schemes.

  10. Using turbocodes on optical links

    Directory of Open Access Journals (Sweden)

    Glenn Claes

    2006-04-01

    Full Text Available The fast evolving telecommunication world is permanently in search for faster and better communication links. On one hand, turbo codes are like a dream come true. Due to their amazing performance, they have become the reference in the word of error detecting and correcting codes. On the other hand, broadband transmission channels like optical fibres can meet the need for higher transmission velocity. In this paper therefore we will bring these two elements together and thus the performance of turbocodes on optical links will be studied. First the turbocode will be optimised throughout an individual analysis of each of its design parameters. Moreover it wil be shown that turbocodes have much better performance than the well known Reed-Solomon codes. Finally we will show that the 8Bit/10Bit code, which is required to comply with the Gigabit Ethernet standard, becomes superfluous when working with turbocodes. All tests were carried out on multimode graded-index glass fibres.

  11. Collagen cross linking: Current perspectives

    Directory of Open Access Journals (Sweden)

    Srinivas K Rao

    2013-01-01

    Full Text Available Keratoconus is a common ectatic disorder occurring in more than 1 in 1,000 individuals. The condition typically starts in adolescence and early adulthood. It is a disease with an uncertain cause and its progression is unpredictable, but in extreme cases, vision deteriorates and can require corneal transplant surgery. Corneal collagen cross-linking (CCL with riboflavin (C3R is a recent treatment option that can enhance the rigidity of the cornea and prevent disease progression. Since its inception, the procedure has evolved with newer instrumentation, surgical techniques, and is also now performed for expanded indications other than keratoconus. With increasing experience, newer guidelines regarding optimization of patient selection, the spectrum of complications and their management, and combination procedures are being described. This article in conjunction with the others in this issue, will try and explore the uses of collagen cross-linking (CXL in its current form.

  12. The Øresund Link

    DEFF Research Database (Denmark)

    Møller, Jacob Steen

    conducted by the owner of the link constituted the basis for an innovative environmental management plan that resulted in zero impact on the water exchange and full compliance with authorities regulations regarding the local environment. The environmental management was based on integrated use......-km link across the Sound could potentially impact the water exchange between the Baltic Sea and the North Sea, and the dredging activities during construction were a threat to the local marine environment. The public interest in the environmental issues together with a pro-active environmental policy...... of hydrodynamic modelling, on line monitoring and access to all environmental information through a GIS based information system. The public attitude towards the project in general and the environmental impact in particular shifted from a very sceptical one at the beginning of the project to a very positive one...

  13. Linking DC together with TRSL

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Yong, X.

    2000-01-01

    Duration Calculus (DC) is an interval-based real-time logic, which can be used in capturing and eliciting users' real-time requirements. The Timed RAISE Specification Language (TRSL) is an extension of the RAISE Specification Language with real-time features. This paper links DC and TRSL together...... in a method for real-time developments. An operational semantics with behavior is specified for TRSL. It is defined what its means for a TRSL process to satisfy a DC requirement, and a method for verifying whether the satisfaction relation holds or not is provided. Our contribution also demonstrates...... a general approach for linking state-based real-time logics together with event-based, timed process algebra languages....

  14. The Nature and Health Link

    OpenAIRE

    Ichoku, Chioma

    2015-01-01

    Undergraduate Independent Study Nature is often overlooked in the health field, and more specifically the physical therapy field. There is evidence that contact with nature has healing effects both psychologically and physically. When it comes to physical therapy, incorporating nature into the regime may provide added benefits. Perhaps it is time that physical therapy consider a research agenda to explore the link. Once benefits are clearly established and outcomes assessed, the field shou...

  15. What Is Linked Historical Data?

    OpenAIRE

    Meroño-Peñuela, Albert; Hoekstra, Rinke; Janowicz, Krzysztof; Schlobach, Stefan; Lambrix, Patrick; Hyvönen, Eero

    2014-01-01

    Datasets that represent historical sources are relative new- comers in the Linked Open Data (LOD) cloud. Following the standard LOD practices for publishing historical sources raises several questions: how can we distinguish between RDF graphs of primary and secondary sources? Should we treat archived and online RDF graphs differently in historical research? How do we deal with change and immutability of a triplified History? To answer these fundamental questions, we model historical primary ...

  16. Linking nutrition-health-agriculture

    OpenAIRE

    Ghosh, S; Griffiths, J. K.; Webb, P.

    2013-01-01

    Agricultural production is intimately linked with health and nutrition as a form of income, a source of food, and a cause of disease. Citing a variety of previous studies, this presentation demonstrates the complexity of the relationships among agriculture and food consumption, food safety, infection, and stunting. The authors demonstrate that increasing agricultural production does not necessarily result in improved nutrition: Although more food may be available, this greater yield may suppl...

  17. Terrestrial teleconnections link global rivers

    Science.gov (United States)

    O'Loughlin, F.; Howden, N. J.; Woods, R. A.; Bates, P. D.

    2013-12-01

    We present analyses of river discharge data from across the world, which we used to identify links between annual river flow regimes across different continents. Our hypothesis was that, as atmospheric processes are subject to large-scale teleconnection patterns, and because these atmospheric processes are inherently linked to precipitation regimes across the world, there should be identifiable links between river flow regimes driven by these atmospheric processes. We used discharge data from the Global Runoff Data Centre (GRDC) to identify cross-correlations (and accounted for serial dependence) between 23 of the world's largest river basins where overlapping data were available over a period of 12 years or more: two in South America; five in Africa; one in Australasia; five in North America and ten in Eurasia. The selected river basins drain approximately a third of the Earth's landmass at their furthest downstream gauging station. Where significant cross-correlations were found, we compared these to known patterns associated with the ENSO and NAO teleconnections. In total, 85 of the 253 possible correlations were deemed significant at p0). We compared these significant cross-correlations with known atmospheric teleconnection patterns, and while these were consistent for the majority of cases, we found a number of significant correlations that are inconsistent with the anticipated effects of known atmospheric teleconnections. Our results provide new insight into the inter-continental links between global river systems and the way in which these are controlled by large-scale atmospheric processes. We suggest this may be useful for global industries, such as insurers or aid agencies, who seek to understand correlations between the magnitudes of extreme events across different regions of the world. For the former, this may enable more efficient management of global liabilities, for the latter it may enable better logistical planning of disaster relief requirements

  18. Linking GHG Emission Trading Systems and Markets

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    Several different types of links are possible between different GHG-mitigation systems. These include: Linking two or more emission trading schemes so that emissions trading can occur both within and between different schemes ('direct links'); and Linking emission trading systems to registries/mechanisms and systems that generate offsets from project based mechanisms or from direct purchases/transfers of AAUs ('indirect links').

  19. Linking world scan and image

    International Nuclear Information System (INIS)

    In march 1994 the Central Planning Bureau (CPB) in the Hague, the National Institute of Public Health and Environmental Protection (RIVM) in Bilthoven and the Institute of Environmental Studies (IES) in Amsterdam started the first phase of a joint research program aimed at creating integrated scenarios of the global economy, GHG emissions, and climate impacts. The goal of the first phase of this project was to design and test a linked version of the economic model WORLD SCAN of the former, and the climate model IMAGE 2 of the latter institute. This first phase has resulted in the planned test runs with an operational version of the linked models by May 1995. The experiences in the first year were encouraging, both in the scientific and the organizational sense. In a sense, a link was made between scientific disciplines: a coupling of disciplines concerning with global economic development and the global physical climate system is difficult and novel. The goal of the project was to integrate long-term economic developments and effects of climate change. Both the WORLD SCAN model and IMAGE 2 provide a consistent analysis of the global system, but from different perspectives. IMAGE 2 simulates climate change and its effects in a global context but treats the economic system as exogenous. WORLD SCAN covers the world economic system in a consistent manner but does not take into account the global environment. The links are constructed in the area of agriculture and energy. The basic idea is that WORLD SCAN determines demand and supply on economic principles, while IMAGE 2 provides information on changes of land area and average quality of productive land, and other damage costs based on its three sub-systems. The demand for energy is fed into IMAGE 2's Energy Industry subsystem (EIS), which in turn determines emissions of greenhouse gases. Furthermore, some additional output from WORLD SCAN on activity levels, prices and capital structure can be used to determine

  20. Dual optical wireless test link

    Czech Academy of Sciences Publication Activity Database

    Wilfert, O.; Kolka, Z.; Biolková, V.; Krivak, P.; Dordová, L.; Fišer, Ondřej; Němeček, J.

    BELLINGHAM: SPIE-INT SOC OPTICAL ENGINEERING, 2008 - (Majumdar, A.; Davis, C.), 70910W/1-70910W/8 ISBN 978-0-8194-7311-0. ISSN 0277-786X. [Free-Space Laser Communications /8./. San Diego (US), 19.08.2008] Institutional research plan: CEZ:AV0Z30420517 Keywords : Free-space optics * atmospheric attenuation * atmospheric visibility * link reliability Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering http://144.206.159.178/ft/CONF/16420595/16420622.pdf

  1. Link prediction in Foursquare network

    OpenAIRE

    Fortuna, Rok; Marovt, Urban

    2016-01-01

    Foursquare is an online social network and can be represented with a bipartite network of users and venues. A user-venue pair is connected if a user has checked-in at that venue. In the case of Foursquare, network analysis techniques can be used to enhance the user experience. One such technique is link prediction, which can be used to build a personalized recommendation system of venues. Recommendation systems in bipartite networks are very often designed using the global ranking method and ...

  2. Provenance in Linked Data Integration

    OpenAIRE

    Omitola, Temitope; Gibbins, Nicholas; Shadbolt, Nigel

    2010-01-01

    The open world of the (Semantic) Web is a global information space offering diverse materials of disparate qualities, and the opportunity to re-use, aggregate, and integrate these materials in novel ways. The advent of Linked Data brings the potential to expose data on the Web, creating new challenges for data consumers who want to integrate these data. One challenge is the ability, for users, to elicit the reliability and/or the accuracy of the data they come across. In this paper, we descri...

  3. Brazil-Africa geological links

    Science.gov (United States)

    Torquato, Joaquim Raul; Cordani, Umberto G.

    1981-04-01

    In this work, the main evidence and conclusions regarding geological links between Brazil and Africa are summarized, with emphasis on the geochronological aspects. Taking into account the geographical position, as well as the similarities in the geochronological pattern, the following main provinces of the two continents are correlated: The Imataca and Falawatra complexes in the Guayana Shield and the Liberian Province of West Africa. The Paraguay-Araguaia and the Rockelide Fold Belts. The Sa˜o Luiz and the West African cratonic areas. The Caririan Fold Belt of northeastern Brazil and the Pan-Africa Belt of Nigeria and Cameroon. The JequiéComplex of Bahia, the Ntem Complex of Cameroon and similar rocks of Gabon and Angola. The Ribeira Fold Belt in Brazil and the West Congo and Damara Belts in West and South Africa. In addition, other geological links are considered, such as some of the major linear fault zones which can be traced across the margins of South America and Africa, in the pre-drift reconstructions. Correlations are also made of the tectonic and stratigraphic evolution of the Paranáand Karroo syneclises, and the Brazilian and African marginal basins around the South Atlantic, during their initial stages. Finally, several similarities in the tectonic evolution of South America and Africa, during and after the onset of drifting, are shown to be compatible with a recent origin for the South Atlantic floor, as required by sea-floor spreading and continental drift between South America and Africa.

  4. Characterization of laser blown molydisilicide links

    International Nuclear Information System (INIS)

    The laser blowing of MoSi2/Poly-n+ fuse links is reported. The polycide links were successfully blown under 10KA of PSG (phospho silicate glass used for isolation between the link and the aluminum) at laser power levels comparable to those used for standard poly link vaporization. Also, the size of the crater in the PSG, produced by the expanding gases associated with link vaporization, was found to be less than that for standard poly links. Laser power levels were found which gave both a near unity blowing probability and produced no substrate damage when the link was located on top of 7-10KA of field oxide. The successful blowing of silicide links is very important with respect to the use of both laser redundancy and silicides in VLSI technology

  5. On the slice genus of links

    OpenAIRE

    Florens, Vincent; Gilmer, Patrick M.

    2003-01-01

    We define Casson-Gordon sigma-invariants for links and give a lower bound of the slice genus of a link in terms of these invariants. We study as an example a family of two component links of genus h and show that their slice genus is h, whereas the Murasugi-Tristram inequality does not obstruct this link from bounding an annulus in the 4-ball.

  6. Network error correction with unequal link capacities

    OpenAIRE

    Kim, Sukwon; Ho, Tracey; Effros, Michelle; Avestimehr, Amir Salman

    2010-01-01

    We study network error correction with unequal link capacities. Previous results on network error correction assume unit link capacities. We consider network error correction codes that can correct arbitrary errors occurring on up to z links. We find the capacity of a network consisting of parallel links, and a generalized Singleton outer bound for any arbitrary network. We show by example that linear coding is insufficient for achieving capacity in general. In our exampl...

  7. Seizures and X-linked intellectual disability

    OpenAIRE

    Stevenson, Roger E.; Holden, Kenton R; Rogers, R. Curtis; Schwartz, Charles E

    2012-01-01

    Intellectual disability occurs as an isolated X-linked trait and as a component of recognizable X-linked syndromes in the company of somatic, metabolic, neuromuscular, or behavioral abnormalities. Seizures accompany intellectual disability in almost half of these X-linked disorders. The spectrum of seizures found in the X-linked intellectual disability syndromes is broad, varying in time of onset, type of seizure, and response to anticonvulsant therapy. The majority of the genes associated wi...

  8. Microprocessor-controlled CAMAC data link module

    International Nuclear Information System (INIS)

    Communication between the central control computer and remote, satellite data-acquisition/control stations at the Clinton P. Anderson Meson Physics Facility (LAMPF) is presently accomplished through the use of CAMAC-based Data Link modules. With the advent of the microprocessor, a new philosophy for digital data communications has evolved. Data Link modules containing microprocessor controllers provide link management and communication network protocol through algorithms executed in the Data Link microprocessor. 13 figures

  9. Track with overlapping links for dry coal extrusion pumps

    Science.gov (United States)

    Saunders, Timothy; Brady, John D

    2014-01-21

    A chain for a particulate material extrusion pump includes a plurality of links, each of the plurality of links having a link body and a link ledge, wherein each link ledge of the plurality of links at least partially overlaps the link body of an adjacent one of the plurality of links.

  10. Electrospinning formaldehyde cross-linked zein solutions

    Science.gov (United States)

    In order to develop zein fibers with improved physical properties and solvent resistance, formaldehyde was used as the cross-linking reagent before spinning. The cross-linking reaction was carried out in either acetic acid or ethanolic-HCl where the amount of cross-linking reagent was between 1 and...

  11. Education and Liberalism: Pursuing the Link

    Science.gov (United States)

    Surridge, Paula

    2016-01-01

    This paper uses data from the 1970 Birth Cohort Study in the UK to explore the well-established link between "liberal" social values and education. Whilst the link itself is well-established, the underlying mechanism is not; the paper explores empirically mechanisms that have been proposed for this link. In particular it considers the…

  12. Verso i Linked Open Data Geografici

    OpenAIRE

    Alfredo Abrescia

    2013-01-01

    Una soluzione riusabile per pubblicare i dati cartografici ed i loro metadati neiportali dei dati liberi sotto forma di Linked Open Data.Towards the Linked Open Data GeographicA reusable solution to publish map data and their metadatainto the free data portals as Linked Open Data.

  13. MidLink Magazine: The Quintessential Collaborative!

    Science.gov (United States)

    McCullen, Caroline

    1999-01-01

    Discusses MidLink Magazine, "the Digital Magazine for Kids, by Kids," that is supported by SAS in School, North Carolina State University, and the University of Central Florida. Describes what a typical MidLink Magazine article looks like, the MidLink Menu that features real working models of technology integration in every discipline, and teacher…

  14. Data links for the EOS TPC

    International Nuclear Information System (INIS)

    We report on the design and performance of high speed data links and slower configuration control links used between the EOS TPC detector and the data processing electronics. Data rates of 5MBytes/s/link are maintained over 30m with optical isolation. Pedestal subtraction, hit detection, and data reordering are performed online. 3 refs., 1 fig

  15. Linking DC together with TRSL

    DEFF Research Database (Denmark)

    Haxthausen, Anne; Yong, Xia

    describing (parts of) the history of the observables of the system,and then define a satisfaction relation in terms of behaviours. DC has previously been linked together with subsets of other event-based process algebra languages, but using another approach:the event-based languages were given a denotational...... constraints on the durations of states of the system, i.e. at a high level of abstraction.However, as a state-based logic, it lacks the ability to specifysequential programs and communicating concurrent processes at a concrete level. The Timed RAISE Specification Language (TRSL) [XG99] has this ability.......TRSL is a real-time extension of the RAISE Specification Language (RSL) [Rlg92] which together with its associated method [Rmg95]and tools has shown to be very useful in the industrial development of software systems. Therefore, a promising approach for the development of real-time systemscould be to use...

  16. Property Testing on Linked Lists

    DEFF Research Database (Denmark)

    Afshani, Peyman; Matulef, Kevin; Wilkinson, Bryan Thomas

    2013-01-01

    a list is sorted (monotone increasing) versus a constant distance from sorted. Our bound is strictly greater than the (logn) queries required in the standard testing model, that allows element access indexed by rank, and strictly less than the (n12) queries required by a weak model that only allows......We define a new property testing model for algorithms that do not have arbitrary query access to the input, but must instead traverse it in a manner that respects the underlying data structure in which it is stored. In particular, we consider the case when the underlying data structure is a linked...... list, and the testing algorithm is allowed to either sample randomly from the list, or walk to nodes that are adjacent to those already visited. We study the well-known monotonicity testing problem in this model, and show that (n13) queries are both necessary and sufficient to distinguish whether...

  17. Characterising Web Site Link Structure

    CERN Document Server

    Zhou, Shi; Petricek, Vaclav

    2007-01-01

    The topological structures of the Internet and the Web have received considerable attention. However, there has been little research on the topological properties of individual web sites. In this paper, we consider whether web sites (as opposed to the entire Web) exhibit structural similarities. To do so, we exhaustively crawled 18 web sites as diverse as governmental departments, commercial companies and university departments in different countries. These web sites consisted of as little as a few thousand pages to millions of pages. Statistical analysis of these 18 sites revealed that the internal link structure of the web sites are significantly different when measured with first and second-order topological properties, i.e. properties based on the connectivity of an individual or a pairs of nodes. However, examination of a third-order topological property that consider the connectivity between three nodes that form a triangle, revealed a strong correspondence across web sites, suggestive of an invariant. ...

  18. PIPELINES AS COMMUNICATION NETWORK LINKS

    Energy Technology Data Exchange (ETDEWEB)

    Kelvin T. Erickson; Ann Miller; E. Keith Stanek; C.H. Wu; Shari Dunn-Norman

    2005-03-14

    This report presents the results of an investigation into two methods of using the natural gas pipeline as a communication medium. The work addressed the need to develop secure system monitoring and control techniques between the field and control centers and to robotic devices in the pipeline. In the first method, the pipeline was treated as a microwave waveguide. In the second method, the pipe was treated as a leaky feeder or a multi-ground neutral and the signal was directly injected onto the metal pipe. These methods were tested on existing pipeline loops at UMR and Batelle. The results reported in this report indicate the feasibility of both methods. In addition, a few suitable communication link protocols for this network were analyzed.

  19. Linking Customer Interaction and Innovation

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Laursen, Keld; Pedersen, Torben

    2011-01-01

    The notion that firms can improve their innovativeness by tapping users and customers for knowledge has become prominent in innovation studies. Similar arguments have been made in the marketing literature. We argue that neither literatures take sufficient account of firm organization. Specifically......, firms that attempt to leverage user and customer knowledge in the context of innovation must design an internal organization appropriate to support it. This can be achieved in particular through the use of new organizational practices, notably, intensive vertical and lateral communication, rewarding...... employees for sharing and acquiring knowledge, and high levels of delegation of decision rights. In this paper, six hypotheses were developed and tested on a data set of 169 Danish firms drawn from a 2001 survey of the 1,000 largest firms in Denmark. A key result is that the link from customer knowledge to...

  20. Link prediction with node clustering coefficient

    Science.gov (United States)

    Wu, Zhihao; Lin, Youfang; Wang, Jing; Gregory, Steve

    2016-06-01

    Predicting missing links in incomplete complex networks efficiently and accurately is still a challenging problem. The recently proposed Cannistrai-Alanis-Ravai (CAR) index shows the power of local link/triangle information in improving link-prediction accuracy. Inspired by the idea of employing local link/triangle information, we propose a new similarity index with more local structure information. In our method, local link/triangle structure information can be conveyed by clustering coefficient of common-neighbors directly. The reason why clustering coefficient has good effectiveness in estimating the contribution of a common-neighbor is that it employs links existing between neighbors of a common-neighbor and these links have the same structural position with the candidate link to this common-neighbor. In our experiments, three estimators: precision, AUP and AUC are used to evaluate the accuracy of link prediction algorithms. Experimental results on ten tested networks drawn from various fields show that our new index is more effective in predicting missing links than CAR index, especially for networks with low correlation between number of common-neighbors and number of links between common-neighbors.

  1. Hacking 360 Link: A hybrid approach

    Directory of Open Access Journals (Sweden)

    John Durno

    2012-10-01

    Full Text Available When the University of Victoria Libraries switched from a locally-hosted link resolver (SFX to a vendor-hosted link resolver (360Link, new strategies were required to effectively integrate the vendor-hosted link resolver with the Libraries' other systems and services. Custom javascript is used to add links to the 360Link page; these links then point at local PHP code running on UVic servers, which can then redirect to appropriate local service or display a form directly. An open source PHP OpenURL parser class is announced. Consideration is given to the importance of maintaining open protocols and standards in the transition to vendor-hosted services.

  2. Adaptive link selection algorithms for distributed estimation

    Science.gov (United States)

    Xu, Songcen; de Lamare, Rodrigo C.; Poor, H. Vincent

    2015-12-01

    This paper presents adaptive link selection algorithms for distributed estimation and considers their application to wireless sensor networks and smart grids. In particular, exhaustive search-based least mean squares (LMS) / recursive least squares (RLS) link selection algorithms and sparsity-inspired LMS / RLS link selection algorithms that can exploit the topology of networks with poor-quality links are considered. The proposed link selection algorithms are then analyzed in terms of their stability, steady-state, and tracking performance and computational complexity. In comparison with the existing centralized or distributed estimation strategies, the key features of the proposed algorithms are as follows: (1) more accurate estimates and faster convergence speed can be obtained and (2) the network is equipped with the ability of link selection that can circumvent link failures and improve the estimation performance. The performance of the proposed algorithms for distributed estimation is illustrated via simulations in applications of wireless sensor networks and smart grids.

  3. Linking Diversity and Disparity Measures

    Directory of Open Access Journals (Sweden)

    Sahadeb Sarkar

    2012-07-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} The purpose of this paper is to examine links between the diversity measures (Patil and Taillie 1982 and the disparity measures (Lindsay 1994, quantities apparently developed for somewhat different purposes. We demonstrate that numerous diversity measures satisfying all the desirable criteria mentioned by Patil and Taillie can be defined by the generating functions of certain disparities and the associated residual adjustment functions. This provides the statistician and the ecologist a wide class of flexible indices for the statistical measurement of diversity.

  4. Links demystified: Periodontitis and cancer

    Directory of Open Access Journals (Sweden)

    Gowri Pendyala

    2013-01-01

    Full Text Available Cancer is marked by the uncontrolled growth of cells, tissue invasion and metastasis to various organs via the circulatory and lymphatic systems. Recent data have expanded the concept that inflammation is a critical component of tumor progression. Many cancers arise from sites of infection, chronic irritation, and inflammation. The tumor microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival, and migration. Periodontal disease, a chronic inflammatory condition is characterized by an oral bacterial infection leading to inflammation within the supporting tissues of the teeth, which often leads to the destruction of the periodontal tissues and alveolar bone that support the teeth. This oral inflammation often has systemic effects leading to an increased concentration of circulating inflammatory markers with the severity of disease being correlated directly with levels of serum inflammatory markers. Periodontal infection has been linked to organ and systemic diseases. There is documented evidence of significant associations between cancer of the lung, kidney, pancreas, hematological and oral cancers, and periodontal disease. This articles reviews and summarizes the possible biological mechanisms involved between periodontal infection and cancer.

  5. IMPACT OF ENERGY AND LINK QUALITY INDICATOR WITH LINK QUALITY ESTIMATORS IN WIRELESS SENSOR NETWORKS

    OpenAIRE

    Bouyahi Mohamed; Zrelli Amira; Rezig Houria; Ezzedine Tahar

    2014-01-01

    The Link Quality Indicator (LQI) and Residual Energy have a fundamental impact on the network performance in Wireless Sensor Networks (WSNs) and affects as well in the life time of nodes. This paper will provide a comparative of Link Quality Estimator, the Link Quality Estimator with Link Quality Indicator and Link Quality Estimator with Residual Energy. In this paper we develop a Collect Tree Protocol (CTP) and compare the performance of LQI and Residual Energy, and show their ef...

  6. Materializing the web of linked data

    CERN Document Server

    Konstantinou, Nikolaos

    2015-01-01

    This book explains the Linked Data domain by adopting a bottom-up approach: it introduces the fundamental Semantic Web technologies and building blocks, which are then combined into methodologies and end-to-end examples for publishing datasets as Linked Data, and use cases that harness scholarly information and sensor data. It presents how Linked Data is used for web-scale data integration, information management and search. Special emphasis is given to the publication of Linked Data from relational databases as well as from real-time sensor data streams. The authors also trace the transformation from the document-based World Wide Web into a Web of Data. Materializing the Web of Linked Data is addressed to researchers and professionals studying software technologies, tools and approaches that drive the Linked Data ecosystem, and the Web in general.

  7. Remarks on Legendrian Self-Linking

    CERN Document Server

    Beasley, Chris; Zhang, Ruoran

    2015-01-01

    The Thurston-Bennequin invariant provides one notion of self-linking for any homologically-trivial Legendrian curve in a contact three-manifold. Here we discuss related analytic notions of self-linking for Legendrian knots in Euclidean space. Our definition is based upon a reformulation of the elementary Gauss linking integral and is motivated by ideas from supersymmetric gauge theory. We recover the Thurston-Bennequin invariant as a special case.

  8. Coherent band pathways between knots and links

    CERN Document Server

    Buck, Dorothy

    2014-01-01

    We categorise coherent band (aka nullification) pathways between knots and 2-component links. Additionally, we characterise the minimal coherent band pathways (with intermediates) between any two knots or 2-component links with small crossing number. We demonstrate these band surgeries for knots and links with small crossing number. We apply these results to place lower bounds on the minimum number of recombinant events separating DNA configurations, restrict the recombination pathways and determine chirality and/or orientation of the resulting recombinant DNA molecules.

  9. Discovering and Mining Links for Protein Databases

    OpenAIRE

    A.Immaculate Mercy; Padmavathi, S.

    2014-01-01

    link analysis procedure for discovering relationships in a protein database or a relational database generalizing simple correspondence analysis. It is based on extracting the links to the related protein database and malfunctioned protein database. The datasets are trained in order to find out missing interactions and the sequences related to them. Further the analysis of links proceeds by performing a random walk defining a Markov chain. The elements of interest a...

  10. Linked open data literacy for librarians

    OpenAIRE

    Hügi, Jasmin; Schneider, René

    2014-01-01

    Linked Data has become an important issue, not only for the process of building the web of data, but also for the mutual knowledge transfer between libraries and the web of data. Based on a study concerning Linked Open Data applications in libraries and the qualifications of future librarians involved in the development of such applications, we built a one day training program for academic librarians. The overall goal was to make librarians literate and heighten awareness concerning the Linke...

  11. UpLink - A Linked Data Editor for RDB-to-RDF Data

    OpenAIRE

    Hert, Matthias; Marsella, Sergio; Reif, Gerald; Gall, Harald

    2011-01-01

    Linked Data builds a machine-processable Web of Data based on a large and growing number of RDF datasets and typed links among them. For the human user, Web-based interfaces were developed to enable browsing and editing Linked Data that is stored as native RDF. However, the majority of data on the current Web is stored in Relational Databases (RDB). This is a challenge for Linked Data browsers and especially for Linked Data editors. In this paper, we present UpLink which is to the best of our...

  12. BER and Availability Measured on FSO Link

    Czech Academy of Sciences Publication Activity Database

    Kvíčala, R.; Kvičera, V.; Grábner, M.; Fišer, Ondřej

    2007-01-01

    Roč. 16, č. 3 (2007), s. 7-12. ISSN 1210-2512 Grant ostatní: Ministry of research and technology(DE) 17050531 Institutional research plan: CEZ:AV0Z30420517 Keywords : free space optical links * quality of service * meteorological optical range * link unavailability * bit error rate Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  13. Exploring the obesity-asthma link

    DEFF Research Database (Denmark)

    Fenger, R V; Gonzalez-Quintela, A; Vidal, C;

    2012-01-01

    Obesity and risk of asthma are linked. Different distributions of adiposity, such as visceral, subcutaneous or ectopic adiposity, may affect asthma risk differently.......Obesity and risk of asthma are linked. Different distributions of adiposity, such as visceral, subcutaneous or ectopic adiposity, may affect asthma risk differently....

  14. The Link Prediction Problem in Bipartite Networks

    CERN Document Server

    Kunegis, Jérôme; Albayrak, Sahin

    2010-01-01

    We define and study the link prediction problem in bipartite networks, specializing general link prediction algorithms to the bipartite case. In a graph, a link prediction function of two vertices denotes the similarity or proximity of the vertices. Common link prediction functions for general graphs are defined using paths of length two between two nodes. Since in a bipartite graph adjacency vertices can only be connected by paths of odd lengths, these functions do not apply to bipartite graphs. Instead, a certain class of graph kernels (spectral transformation kernels) can be generalized to bipartite graphs when the positive-semidefinite kernel constraint is relaxed. This generalization is realized by the odd component of the underlying spectral transformation. This construction leads to several new link prediction pseudokernels such as the matrix hyperbolic sine, which we examine for rating graphs, authorship graphs, folksonomies, document--feature networks and other types of bipartite networks.

  15. Mapping the x-linked lymphoproliferative syndrome

    International Nuclear Information System (INIS)

    The X-linked lymphoproliferative syndrome is triggered by Epstein-Barr virus infection and results in fatal mononucleosis, immunodeficiency, and lymphoproliferative disorders. This study shows that the mutation responsible for X-linked lymphoproliferative syndrome is genetically linked to a restriction fragment length polymorphism detected with the DXS42 probe (from Xq24-q27). The most likely recombination frequency between the loci is 4%, and the associated logarithm of the odds is 5.26. Haplotype analysis using flanking restriction fragment length polymorphism markers indicates that the locus for X-linked lymphoproliferative syndrome is distal to probe DXS42 but proximal to probe DXS99 (from Xq26-q27). It is now possible to predict which members of a family with X-linked lymphoproliferative syndrome are carrier females and to diagnose the syndrome prenatally

  16. Mapping the x-linked lymphoproliferative syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Skare, J.C.; Milunsky, A.; Byron, K.S.; Sullivan, J.L.

    1987-04-01

    The X-linked lymphoproliferative syndrome is triggered by Epstein-Barr virus infection and results in fatal mononucleosis, immunodeficiency, and lymphoproliferative disorders. This study shows that the mutation responsible for X-linked lymphoproliferative syndrome is genetically linked to a restriction fragment length polymorphism detected with the DXS42 probe (from Xq24-q27). The most likely recombination frequency between the loci is 4%, and the associated logarithm of the odds is 5.26. Haplotype analysis using flanking restriction fragment length polymorphism markers indicates that the locus for X-linked lymphoproliferative syndrome is distal to probe DXS42 but proximal to probe DXS99 (from Xq26-q27). It is now possible to predict which members of a family with X-linked lymphoproliferative syndrome are carrier females and to diagnose the syndrome prenatally.

  17. Propagation engineering in radio links design

    CERN Document Server

    Ghasemi, Abdollah; Ghasemi, Farshid

    2013-01-01

    Propagation Engineering in Radio Link Design covers the basic principles of radiowaves propagation in a practical manner.  This fundamental understanding enables the readers to design radio links efficiently. This book elaborates on new achievements as well as recently developed propagation models.  This is in addition to a comprehensive overview of fundamentals of propagation in various scenarios. It examines theoretical calculations, approaches and applied procedures needed for radio links design. The authors study and analysis of the main propagation phenomena and its mechanisms based on the recommendations of International Telecommunications Union, (ITU). The book has been organized in 9 chapters and examines the role of antennas and passive reflectors in radio services, propagation mechanisms related to radar, satellite, short distance, broadcasting and trans-horizon radio links, with two chapters devoted to radio noise and main  parameters of radio link design. The book presents some 278 illustration...

  18. A generalized theory of preferential linking

    CERN Document Server

    Hu, Haibo; Liu, Xuan

    2013-01-01

    There are diverse mechanisms driving the evolution of social networks. A key open question dealing with understanding their evolution is: How various preferential linking mechanisms produce networks with different features? In this paper we first empirically study preferential linking phenomena in an evolving online social network, find and validate the linear preference. We propose an analyzable model which captures the real growth process of the network and reveals the underlying mechanism dominating its evolution. Furthermore based on preferential linking we propose a generalized model reproducing the evolution of online social networks, present unified analytical results describing network characteristics for 27 preference scenarios, and explore the relation between preferential linking mechanism and network features. We find that within the framework of preferential linking analytical degree distributions can only be the combinations of finite kinds of functions which are related to rational, logarithmic...

  19. Ubiquitousness of link-density and link-pattern communities in real-world networks

    CERN Document Server

    Šubelj, Lovro

    2011-01-01

    Community structure appears to be an intrinsic property of many complex real-world networks. However, recent work shows that real-world networks reveal even more sophisticated modules than classical cohesive (link-density) communities. In particular, networks can also be naturally partitioned according to similar patterns of connectedness between the nodes, revealing link-pattern communities. We here propose a balanced propagation based algorithm that can extract both link-density and link-pattern communities, without any prior knowledge of the true structure. The algorithm was first validated on different classes of synthetic benchmark networks with community structure, and also on random networks. We have then further applied the algorithm to different social, information, technological and biological networks, where it indeed reveals meaningful (composites of) link-density and link-pattern communities. The results thus seem to imply that, similarly as link-density counterparts, link-pattern communities app...

  20. Link Characteristics and Forecast for Internet Users

    Institute of Scientific and Technical Information of China (English)

    JINZhigang; LUOYongmei

    2004-01-01

    For a user sharing Internet resources the “Weather Forecast” of the Internet is important. As a user, he has no right to access the status of routers/switches and has not enough information about the overall network. In order to give users useful information and the forecast, this paper proposes a new approach to measure and forecast Internet link status and Local area network (LAN) traffic. In this paper, the design and implementation of a user-oriented, generalized system are proposed for characterizing the links and producing short-term performance forecasts based on historical link characteristics. Pathchar, packet pair are used to measure the latency of hops along a link, and TCPdump is used to collect the traffic of the local LAN. When using these measurement tools in appropriate time scales, we can set up a set of indicators for link status and do prediction for the link characteristics in the future. To improve the accuracy of the estimate of bandwidth, the Extreme value theory (EVT) is deployed. The experimental data show the feasibility of EVT filters. The data show that the EVT resuits are more close to nominal bandwidth. The FARIMA (p,d,q) (fractional autoregressive integrated moving average) based prediction is also presented to forecast the furure status of links and the local traffic.

  1. Web Applications of Bibliometrics and Link Analysis

    Directory of Open Access Journals (Sweden)

    Faribourz Droudi

    2010-04-01

    Full Text Available The present study aims to introduce and analyze bibliometric application within Web and also to expounds on the status of link analysis in order to point out its application with respect to the existing web-based information sources. Findings indicate that bibliometrics could have required application in the area of digital resources available through Net. Link analysis is a process by which one could make statistical analysis of correlation between hyperlinks and therefore understand the accuracy, veracity and efficacy of citations within a digital document. Link analysis, in effect, is counted as a part of information ranking algorithm within the web environment. The number, linkage and quality of given links to a website are of utmost importance for ranking/status in the Web. The tools applied in this topic include, page ranking strategy, link analysis algorithm, latent semantic indexing and the classical input-output model. The present study analyzes Big Web and Small Web link analysis and explains the means for utilizing web charts in order to better understand the link analysis process.

  2. Histone cross-linking by transglutaminase.

    Science.gov (United States)

    Kim, Jae-Hong; Nam, Kang Hoon; Kwon, Oh-Seok; Kim, In Gyu; Bustin, Michael; Choy, Hyon E; Park, Sang Chul

    2002-05-24

    Transglutaminases irreversibly catalyze covalent cross-linking of proteins by forming isopeptide bonds between peptide-bound glutamine and lysine residues. Among several transglutaminases, tissue-type transglutaminase (tTGase) is most ubiquitously found in every type of cells and tissues in animals, but its natural substrate has yet to be identified. In an attempt to identify the natural substrate for tTGase, we examined in vitro if core histones were subject to cross-linking by tTGase. We found core histone subunits, H2A and H2B, were specifically cross-linked by tTGase. The cross-linking was between either one or both glutamines at C-terminal end of H2A (-VTIAQ104 GGVLPNTQ112 SVLLPKKTESSKSK-C' end) and the first and/or third lysine from C-terminal end of H2B (-AVESEGK116 AVTKYTSSK125-C' end). The cross-linking occurred only when these subunits were released from nucleosome but not when these were organized in nucleosome. Most interestingly, in chicken erythrocyte the cross-linked H2A-H2B was present in a significant amount. From these results, it can be proposed that tTGase-mediated cross-linking is an another form of core histone modification and it may play a role of chromatin condensation during erythrocyte differentiation. PMID:12054678

  3. Predicting Anchor Links between Heterogeneous Social Networks

    CERN Document Server

    Sajadmanesh, Sina; Khodadadi, Ali

    2016-01-01

    People usually get involved in multiple social networks to enjoy new services or to fulfill their needs. Many new social networks try to attract users of other existing networks to increase the number of their users. Once a user (called source user) of a social network (called source network) joins a new social network (called target network), a new inter-network link (called anchor link) is formed between the source and target networks. In this paper, we concentrated on predicting the formation of such anchor links between heterogeneous social networks. Unlike conventional link prediction problems in which the formation of a link between two existing users within a single network is predicted, in anchor link prediction, the target user is missing and will be added to the target network once the anchor link is created. To solve this problem, we use meta-paths as a powerful tool for utilizing heterogeneous information in both the source and target networks. To this end, we propose an effective general meta-pat...

  4. Linked-OWL : A new approach for dynamic linked data service workflow composition

    OpenAIRE

    Hussien Ahmad; Salah Dowaji

    2013-01-01

    The shift from Web of Document into Web of Data based on Linked Data principles defined by Tim Berners-Lee posed a big challenge to build and develop applications to work in Web of Data environment. There are several attempts to build service and application models for Linked Data Cloud. In this paper, we propose a new service model for linked data "Linked-OWL" which is based on RESTful services and OWL-S and copes with linked data principles. This new model shifts the service concept from fu...

  5. Markkinointiviestintä Linked By Music Oy

    OpenAIRE

    Makkonen, Joonas; Kairamo, Teemu

    2014-01-01

    Tämän opinnäytetyön aiheena oli Markkinointiviestintäsuunnitelma aloittelevalle Linked by Music Oy:lle. Opinnäytetyön tavoite oli luoda toimiva ja pienenbudjetin markkinointiviestintäsuunnitelma Linked by Musicin lanseerauksen ympärille. Erityisenä haasteena olikin rakentaa markkinointiviestintäsuunnitelmasta tehokas ilman, että siihen käytetään paljon rahaa. Linked by Musicia ei ole vielä lanseerattu, joten markkinointiviestintäsuunnitelma keskittyi lanseerauksen ympärille ja ensimmäisille ...

  6. Field experience with optical data links

    International Nuclear Information System (INIS)

    A previous report on a high performance dc to 1 MHz analog fiber-optic telemetry link was developed especially for the neutral beam power supplies on the Tokamak Fusion Test Reactor (TFTR). This paper describes the field experience with that link. The field operation of the optical data links began in late 1983. The performance of this system as found to be exemplary. The testing of the overall neutral beam system was accelerated by the introduction of this specially developed electronics. The accuracy and stability of the telemetry, coupled with the remote calibration feature enabled the neutral beam system operators to concentrate on the development of the neutral beam system

  7. Link mining models, algorithms, and applications

    CERN Document Server

    Yu, Philip S; Faloutsos, Christos

    2010-01-01

    This book presents in-depth surveys and systematic discussions on models, algorithms and applications for link mining. Link mining is an important field of data mining. Traditional data mining focuses on 'flat' data in which each data object is represented as a fixed-length attribute vector. However, many real-world data sets are much richer in structure, involving objects of multiple types that are related to each other. Hence, recently link mining has become an emerging field of data mining, which has a high impact in various important applications such as text mining, social network analysi

  8. Link prediction in complex networks: A survey

    Science.gov (United States)

    Lü, Linyuan; Zhou, Tao

    2011-03-01

    Link prediction in complex networks has attracted increasing attention from both physical and computer science communities. The algorithms can be used to extract missing information, identify spurious interactions, evaluate network evolving mechanisms, and so on. This article summaries recent progress about link prediction algorithms, emphasizing on the contributions from physical perspectives and approaches, such as the random-walk-based methods and the maximum likelihood methods. We also introduce three typical applications: reconstruction of networks, evaluation of network evolving mechanism and classification of partially labeled networks. Finally, we introduce some applications and outline future challenges of link prediction algorithms.

  9. Chemical cross-linking of Chlamydia trachomatis

    DEFF Research Database (Denmark)

    Birkelund, Svend; Lundemose, AG; Christiansen, Gunna

    1988-01-01

    Purified elementary bodies (EBs) of Chlamydia trachomatis serovar L2 were analyzed by chemical cross-linking with disuccinimidyl selenodipropionate. The effect of the cross-linking was analyzed by immunoblotting sodium dodecyl sulfate-polyacrylamide gel electrophoresis-separated components which...... forms of MOMP without LPS, was observed. A totally different membrane structure must be present in reticulate bodies, since there, MOMP was so heavily cross-linked that it did not enter the polyacrylamide gel and thus became impossible to analyze. Furthermore, the monoclonal antibody, which reacted with...

  10. External Link Policy | Division of Cancer Prevention

    Science.gov (United States)

    The following graphic notice means that you are leaving the DCP Web site: (link is external)This external link provides additional information that is consistent with the intended purpose of DCP.The National Cancer Institute (NCI) cannot attest to the accuracy of a non-federal site.Linking to a non-federal site does not constitute an endorsement by HHS or any of its employees of the sponsors or the information and products presented on the site.You will be subject to the destination site |

  11. Framework for Matching and Linking Large Ontologies

    OpenAIRE

    Onn , Weng Kow; Niu, Michelle Lim Sien; Johannsen, Gudrun; Keizer, Johannes; Lukose, Dickson

    2012-01-01

    The Linked Open Data (LOD) initiative is the first large-scale attempt at realizing the Semantic Web vision of Tim Berners-Lee. As of September 2011, there are almost 300 knowledge bases linked together and available for public access through both web browsers as well as semantic applications. However, the task of building the links between knowledge basesis still a laborious manual task and as the LOD cloud continues to grow rapidly,the task becomes more daunting. This paper looks at the AGR...

  12. The Gigabit Link Interface Board (GLIB) ecosystem

    CERN Document Server

    Vichoudis, P; Baron, S; Barros Marin, M; Bobillier, V; Chramowitz, J; Haas, S; Hansen, M; Joos, M; Lobato Pardavila, L; Petit, P; Prosser, A; Vasey, F

    2013-01-01

    The Gigabit Link Interface Board (GLIB) project is an FPGA-based platform for users of high-speed optical links in high energy physics experiments. The major hardware component of the platform is the GLIB Advanced Mezzanine Card (AMC). Additionally to the AMC, auxiliary components are developed that enhance GLIB platform's I/O bandwidth and compatibility with legacy and future triggering and/or data acquisition interfaces. This article focuses on the development of the auxiliary components that together with the GLIB AMC offer a complete solution for beam/irradiation tests of detector modules and evaluation of optical links.

  13. Link community detection based on line graphs with a novel link similarity measure

    Science.gov (United States)

    Wang, Guishen; Huang, Lan; Wang, Yan; Pang, Wei; Ma, Qin

    2016-02-01

    Link community gradually unfolds its capacity in complex network research. In this paper, a novel link similarity measure on line graphs is proposed. This measure can be adapted to different types of networks with an adjustable parameter. We prove its value converges to a limit on line graphs with the relationship of the nonneighbor links taken into account. Based on this similarity measure, we propose a novel link community detection algorithm for link clustering on line graphs. The detection algorithm combines the novel link similarity measure with the classic Markov Cluster (MCL) Algorithm and determines the link community partitions by calculating an extended modularity measure. Extensive experiments on two types of complex networks demonstrate the effectiveness, reliability and rationality of our solution in contrast to the other two classical algorithms.

  14. Linked-OWL: A new approach for dynamic linked data service workflow composition

    Directory of Open Access Journals (Sweden)

    Hussien Ahmad

    2013-06-01

    Full Text Available The shift from Web of Document into Web of Data based on Linked Data principles defined by Tim Berners-Lee posed a big challenge to build and develop applications to work in Web of Data environment. There are several attempts to build service and application models for Linked Data Cloud. In this paper, we propose a new service model for linked data "Linked-OWL" which is based on RESTful services and OWL-S and copes with linked data principles. This new model shifts the service concept from functions into linked data things and opens the road for Linked Oriented Architecture (LOA and Web of Services as part and on top of Web of Data. This model also provides high level of dynamic service composition capabilities for more accurate dynamic composition and execution of complex business processes in Web of Data environment.

  15. Overactive Thyroid Linked to Breast Cancer Risk

    Science.gov (United States)

    ... nih.gov/medlineplus/news/fullstory_157203.html Overactive Thyroid Linked to Breast Cancer Risk But researchers added ... 2016 (HealthDay News) -- Women who have an overactive thyroid gland might be at greater risk for breast ...

  16. Mercury Poisoning Linked to Skin Products

    Science.gov (United States)

    ... Products For Consumers Home For Consumers Consumer Updates Mercury Poisoning Linked to Skin Products Share Tweet Linkedin ... situations, criminal prosecution. back to top Dangers of Mercury Exposure to mercury can have serious health consequences. ...

  17. Predicting missing links via correlation between nodes

    Science.gov (United States)

    Liao, Hao; Zeng, An; Zhang, Yi-Cheng

    2015-10-01

    As a fundamental problem in many different fields, link prediction aims to estimate the likelihood of an existing link between two nodes based on the observed information. Since this problem is related to many applications ranging from uncovering missing data to predicting the evolution of networks, link prediction has been intensively investigated recently and many methods have been proposed so far. The essential challenge of link prediction is to estimate the similarity between nodes. Most of the existing methods are based on the common neighbor index and its variants. In this paper, we propose to calculate the similarity between nodes by the Pearson correlation coefficient. This method is found to be very effective when applied to calculate similarity based on high order paths. We finally fuse the correlation-based method with the resource allocation method, and find that the combined method can substantially outperform the existing methods, especially in sparse networks.

  18. Early Alzheimer's Linked to Brain 'Leakage'

    Science.gov (United States)

    ... nih.gov/medlineplus/news/fullstory_159116.html Early Alzheimer's Linked to Brain 'Leakage' Normally, blood-brain barrier ... HealthDay News) -- People in the early stages of Alzheimer's disease may have more "leaks" in the barrier ...

  19. The links between science and industrialization

    OpenAIRE

    Dugan, David

    2004-01-01

    Simon Schaffer explains the links between science and industrialization. He explains the history of the Royal Institution where he is standing and the research into agriculture and chemistry which was so important.

  20. Network error correction with unequal link capacities

    CERN Document Server

    Kim, Sukwon; Effros, Michelle; Avestimehr, Amir Salman

    2010-01-01

    This paper studies the capacity of single-source single-sink noiseless networks under adversarial or arbitrary errors on no more than z edges. Unlike prior papers, which assume equal capacities on all links, arbitrary link capacities are considered. Results include new upper bounds, network error correction coding strategies, and examples of network families where our bounds are tight. An example is provided of a network where the capacity is 50% greater than the best rate that can be achieved with linear coding. While coding at the source and sink suffices in networks with equal link capacities, in networks with unequal link capacities, it is shown that intermediate nodes may have to do coding, nonlinear error detection, or error correction in order to achieve the network error correction capacity.

  1. X-linked hypophosphatemic rickets without 'rickets'

    International Nuclear Information System (INIS)

    Wrist and knee radiographs from children with X-linked hypophosphatemic rickets were analyzed and compared with those from normal children and children with established rickets to assess whether radiographically apparent rickets is a consistent abnormality in X-linked hypophosphatemia. The absence or presence of rickets was correctly identified in 94.8% of wrist and knee films from normal and positive controls. In contrast, patients with X-linked hypophosphatemia exhibited rachitic abnormalities in only 5 of 11 wrist and 13 of 15 knee radiographs. Our data indicate that radiographically detectable rickets is a variable abnormality of X-linked hypophosphatemia and does not provide an unambiguous index for the diagnosis of this disease. (orig./GDG)

  2. Hormone May Be Linked to Teenage Obesity

    Science.gov (United States)

    ... 159014.html Hormone May Be Linked to Teenage Obesity Researchers suspect low levels of spexin might play ... reduced levels of this hormone in adults with obesity. Overall, our findings suggest spexin may play a ...

  3. Bounded link prediction for very large networks

    CERN Document Server

    Cui, Wei; Xu, Zhongqi

    2015-01-01

    Evaluation of link prediction methods is a hard task in very large complex networks because of the inhibitive computational cost. By setting a lower bound of the number of common neighbors (CN), we propose a new framework to efficiently and precisely evaluate the performances of CN-based similarity indices in link prediction for very large heterogeneous networks. Specifically, we propose a fast algorithm based on the parallel computing scheme to obtain all the node pairs with CN values larger than the lower bound. Furthermore, we propose a new measurement, called self-predictability, to quantify the performance of the CN-based similarity indices in link prediction, which on the other side can indicate the link predictability of a network.

  4. Broadcasting satellite feeder links - Characteristics and planning

    Science.gov (United States)

    Kiebler, J. W.

    1982-01-01

    The paper presents the results of recent studies by the Feeder Link Sub-Working Group of the FCC Advisory Committee for the 1983 Regional Administrative Radio Conference (RARC). These studies conclude that specification of a few key parameters will make feeder link planning relatively straightforward. Feeder links can be located anywhere within a country if satellite orbit locations are separated by 10 deg for adjacent service areas and key parameter values presented in the paper are adopted. Colocated satellites serving a common service area need special attention to attain sufficient isolation between a desired channel and its adjacent cross-polarized channels and alternate co-polarized channels. In addition to presenting planning conclusions by the Advisory Committee, the paper presents and analyzes actions of the International Radio Consultative Committee's Conference Planning Meeting (CPM) concerning feeder links. The CPM reached conclusions similar to, and compatible with, those of the Advisory Committee.

  5. Pesticides Linked to Raised Risk of ALS

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_158737.html Pesticides Linked to Raised Risk of ALS One toxin ... MONDAY, May 9, 2016 (HealthDay News) -- Exposure to pesticides and other chemicals may increase the risk for ...

  6. A Robust Parsing Algorithm For Link Grammars

    CERN Document Server

    Grinberg, D; Sleator, D; Grinberg, Dennis; Lafferty, John; Sleator, Daniel

    1995-01-01

    In this paper we present a robust parsing algorithm based on the link grammar formalism for parsing natural languages. Our algorithm is a natural extension of the original dynamic programming recognition algorithm which recursively counts the number of linkages between two words in the input sentence. The modified algorithm uses the notion of a null link in order to allow a connection between any pair of adjacent words, regardless of their dictionary definitions. The algorithm proceeds by making three dynamic programming passes. In the first pass, the input is parsed using the original algorithm which enforces the constraints on links to ensure grammaticality. In the second pass, the total cost of each substring of words is computed, where cost is determined by the number of null links necessary to parse the substring. The final pass counts the total number of parses with minimal cost. All of the original pruning techniques have natural counterparts in the robust algorithm. When used together with memoization...

  7. Pesticides Linked to Raised Risk of ALS

    Science.gov (United States)

    ... nlm.nih.gov/medlineplus/news/fullstory_158737.html Pesticides Linked to Raised Risk of ALS One toxin ... MONDAY, May 9, 2016 (HealthDay News) -- Exposure to pesticides and other chemicals may increase the risk for ...

  8. Poverty Linked to Asthma, Allergy Treatment Failure

    Science.gov (United States)

    ... nlm.nih.gov/medlineplus/news/fullstory_157642.html Poverty Linked to Asthma, Allergy Treatment Failure Patients from ... said. But the study did not show a cause-and-effect relationship between income and asthma and ...

  9. Hormone May Be Linked to Teenage Obesity

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_159014.html Hormone May Be Linked to Teenage Obesity Researchers suspect ... may have lower levels of a weight-regulating hormone than normal-weight teens, a new study says. " ...

  10. Prenatal Inflammation Linked to Autism Risk

    Science.gov (United States)

    ... Thursday, January 24, 2013 Prenatal inflammation linked to autism risk Maternal inflammation during early pregnancy may be related to an increased risk of autism in children, according to new findings supported by ...

  11. Gut Microbes Linked to Rheumatoid Arthritis

    Science.gov (United States)

    ... ask if this is indeed the case.” — by Carol Torgan, Ph.D. Related Links Feeling Out of ... Assistant Editors: Vicki Contie, Tianna Hicklin, Ph.D., Carol Torgan, Ph.D. NIH Research Matters is a ...

  12. Language for International Communication: Linking Interdisciplinary Perspectives

    OpenAIRE

    University of Latvia. Faculty of Humanities, Department of English Studies and Centre for Applied Linguistics

    2014-01-01

    This collection contains papers delivered at the 2nd international symposium "Language for International Communication: Linking Interdisciplinary Perspectives" held at the University of Latvia, Latvia, on 23-24 May 2013.

  13. Linking Medicare, Medicaid, and Cancer Registry Data...

    Data.gov (United States)

    U.S. Department of Health & Human Services — Linking Medicare, Medicaid, and Cancer Registry Data to Study the Burden of Cancers in West Virginia In the United States, the elderly carry an unequal burden of...

  14. Bounded link prediction in very large networks

    Science.gov (United States)

    Cui, Wei; Pu, Cunlai; Xu, Zhongqi; Cai, Shimin; Yang, Jian; Michaelson, Andrew

    2016-09-01

    Evaluating link prediction methods is a hard task in very large complex networks due to the prohibitive computational cost. However, if we consider the lower bound of node pairs' similarity scores, this task can be greatly optimized. In this paper, we study CN index in the bounded link prediction framework, which is applicable to enormous heterogeneous networks. Specifically, we propose a fast algorithm based on the parallel computing scheme to obtain all node pairs with CN values larger than the lower bound. Furthermore, we propose a general measurement, called self-predictability, to quantify the performance of similarity indices in link prediction, which can also indicate the link predictability of networks with respect to given similarity indices.

  15. Using Linked Data in Learning Analytics

    NARCIS (Netherlands)

    d'Aquin, Mathieu; Dietze, Stefan; Drachsler, Hendrik; Herder, Eelco

    2013-01-01

    d'Aquin, M., Dietze, S., Drachsler, H., & Herder, E. (2013, April). Using Linked Data in Learning Analytics. Tutorial given at LAK 2013, the Third Conference on Learning Analytics and Knowledge, Leuven, Belgium.

  16. Five New Genes Linked to Colon Cancer

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_159556.html Five New Genes Linked to Colon Cancer But researchers say it's ... 2016 (HealthDay News) -- Scientists have identified five new gene mutations that may be tied to colon cancer. ...

  17. Early Alzheimer's Linked to Brain 'Leakage'

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_159116.html Early Alzheimer's Linked to Brain 'Leakage' Normally, blood-brain barrier ... HealthDay News) -- People in the early stages of Alzheimer's disease may have more "leaks" in the barrier ...

  18. Linking IMAGE 2 and WORLD SCAN

    International Nuclear Information System (INIS)

    The links between the climate model IMAGE 2 and the economic model WORLD SCAN, which are set up to obtain an integrated scenario instrument for comprehensive and consistent climate-economy scenarios, are presented and discussed. The links are made with respect to energy (in WORLD SCAN) and agriculture (in IMAGE 2), thus providing a consistent linkage with feedbacks running both ways. 2 figs., 1 tab

  19. Catenanes: Fifty Years of Molecular Links

    OpenAIRE

    Gil-Ramírez, Guzmán; Leigh, David A.; Stephens, Alexander J.

    2015-01-01

    Half a century after Schill and Lüttringhaus carried out the first directed synthesis of a [2]catenane, a plethora of strategies now exist for the construction of molecular Hopf links (singly interlocked rings), the simplest type of catenane. The precision and effectiveness with which suitable templates and/or noncovalent interactions can arrange building blocks has also enabled the synthesis of intricate and often beautiful higher order interlocked systems, including Solomon links, Borromean...

  20. Microwaves photonic links components and circuits

    CERN Document Server

    Rumelhard, Christian; Billabert, Anne-Laure

    2013-01-01

    This book presents the electrical models for the different elements of a photonic microwave link like lasers, external modulators, optical fibers, photodiodes and phototransistors. The future trends of these components are also introduced: lasers to VCSEL, external modulators to electro-absorption modulators, glass optical fibers to plastic optical fibers, photodiodes to UTC photodiodes or phototransistors. It also describes an original methodology to evaluate the performance of a microwave photonic link, based on the developed elcetrical models, that can be easily incorporated in

  1. Augmenting SCORM Manifests with Adaptive Links

    OpenAIRE

    Abdullah, NA; Bailey, CP; Davis, HC

    2004-01-01

    This paper describes an experiment to augment SCORM manifests with adaptive links using AuldLinky in order to promote content reusability, interoperability and personalized e-learning. Our technique involves the automatic deduction of a concept map from a manifest and the transformation of its pertinent elements into FOHM (Fundamental Object Hypermedia Model) objects before augmenting the information with complimentary and adaptive links using AuldLinky.

  2. Intrinsically n-linked Complete Bipartite Graphs

    OpenAIRE

    O'Donnol, Danielle

    2005-01-01

    We prove that every embedding of $K_{2n+1,2n+1}$ into $\\R^3$ contains a non-split link of $n$-components. Further, given an embedding of $K_{2n+1,2n+1}$ in $\\R^3$, every edge of $K_{2n+1,2n+1}$ is contained in a non-split $n$-component link in $K_{2n+1,2n+1}$.

  3. Quantum group invariants and link polynomials

    International Nuclear Information System (INIS)

    A general method is developed for constructing quantum group invariants and determining their eigenvalues. Applied to the universal R-matrix this method leads to the construction of a closed formula for link polynomials. To illustrate the application of this formula, the quantum groups Uq(E8), Uq(so(2m+1)) and Uq(gl(m)) are considered as examples, and corresponding link polynomials are obtained. (orig.)

  4. A Robust Parsing Algorithm For Link Grammars

    OpenAIRE

    Grinberg, Dennis; Lafferty, John; Sleator, Daniel

    1995-01-01

    In this paper we present a robust parsing algorithm based on the link grammar formalism for parsing natural languages. Our algorithm is a natural extension of the original dynamic programming recognition algorithm which recursively counts the number of linkages between two words in the input sentence. The modified algorithm uses the notion of a null link in order to allow a connection between any pair of adjacent words, regardless of their dictionary definitions. The algorithm proceeds by mak...

  5. Cross-modal links in spatial attention.

    OpenAIRE

    Driver, J; Spence, C.

    1998-01-01

    A great deal is now known about the effects of spatial attention within individual sensory modalities, especially for vision and audition. However, there has been little previous study of possible cross-modal links in attention. Here, we review recent findings from our own experiments on this topic, which reveal extensive spatial links between the modalities. An irrelevant but salient event presented within touch, audition, or vision, can attract covert spatial attention in the other modaliti...

  6. Legendrian framings for two-bridge links

    CERN Document Server

    Baader, Sebastian

    2009-01-01

    We define the Thurston-Bennequin polytope of a two-component link as the convex hull of all pairs of integers that arise as framings of a Legendrian representative. The main result of this paper is a description of the Thurston-Bennequin polytope for two-bridge links. As an application, we construct non-quasipositive surfaces in $\\R^3$ all whose sub-annuli are quasipositive.

  7. Hodge-type structures as link invariants

    OpenAIRE

    Borodzik, Maciej; Nemethi, Andras

    2010-01-01

    Based on some analogies with the Hodge theory of isolated hypersurface singularities, we define Hodge-type numerical invariants (called H-numbers) of any, not necessarily algebraic, link in $S^3$. They contain the same information as the (normalized) real Seifert matrix. We study their basic properties, we express the Tristram-Levine signatures and the higher order Alexander polynomial in terms of them. Motivated by singularity theory, we also introduce the spectrum of the link (determined fr...

  8. Linking Ergonomics with the Human Resources Management

    OpenAIRE

    Aurel MANOLESCU; Ion VERBONCU; Victor LEFTER; Cristian MARINAS

    2010-01-01

    During the last years, ergonomics became one of the reference domains in the managerial theory and practice. Ergonomics is a major component of the human resources management and also, it is an important factor of performances. Ergonomics is the link between efficiency, effectiveness, security and heath and in this context it is necessary to approach the ergonomics and its impact on the process of the organizational development and on the employees. The links between ergonomics and Human Reso...

  9. Virgil database for rich links (1999 update).

    OpenAIRE

    Achard, F; Vaysseix, G; Dessen, P; Barillot, E

    1999-01-01

    With so many databases available for research in the Human Genome Project, it is crucial to efficiently relate information from different resources. For that purpose, we maintain Virgil, a database of rich links for data browsing, data analysis and database interconnection. Virgil current version contains more than 40 000 rich links from five major databases: SWISS-PROT, GenBank, PDB, GDB and OMIM. Materials described in this paper are available from http://www.infobiogen.fr/services/virgil/

  10. Disease : the link between geochemistry and health

    OpenAIRE

    Fordyce, Fiona; Smith, Barry

    1997-01-01

    Many minerals that are essential to human health in small doses can be toxic if ingested in excess. These minerals enter the human population via the plants, animals and water that make up our food supply and through the ingestion and inhalation of dusts derived from our living environment. Animals and plants depend ultimately on soil, water and rock for the provision of minerals hence the link between geochemistry and health. This link is particularly important in developing countries where ...

  11. Diabetes and gastric cancer: The potential links

    OpenAIRE

    Tseng, Chin-Hsiao; Tseng, Farn-Hsuan

    2014-01-01

    This article reviews the epidemiological evidence linking diabetes and gastric cancer and discusses some of the potential mechanisms, confounders and biases in the evaluation of such an association. Findings from four meta-analyses published from 2011 to 2013 suggest a positive link, which may be more remarkable in females and in the Asian populations. Putative mechanisms may involve shared risk factors, hyperglycemia, Helicobacter pylori (H. pylori) infection, high salt intake, medications a...

  12. Energy: The Link between GDP and Emissions

    OpenAIRE

    Jan-Erik Lane

    2013-01-01

    The global energy-environment conundrum unfolds now with more and more evidence confirming the climate change hypothesis. The accumulation of greenhouses gases in the atmosphere is strongly linked with economic production, the GDP indicator. Here we give the exact relationships between GDP, energy consumption and greenhouse gases emissions, over time and cross-sectionally for the entire globe. The intermediating link between total GDP and total emissions is, it must be emphasized, the energy ...

  13. GDP-linked bonds and sovereign default

    OpenAIRE

    Barr, David; Bush, Oliver; Pienkowski, Alex

    2014-01-01

    Using a calibrated model of endogenous sovereign default, we explore how GDP-linked bonds can raise the maximum sustainable debt level of a government, and substantially reduce the incidence of default. The model explores both the costs (in particular the GDP risk premium) and the benefits of issuing GDP-linked bonds. It concludes that significant welfare gains can be achieved by indexing debt to GDP.

  14. Effect of Link Flexibility on tip position of a single link robotic arm

    Science.gov (United States)

    Madhusudan Raju, E.; Siva Rama Krishna, L.; Mouli, Y. Sharath Chandra; Nageswara Rao, V.

    2015-12-01

    The flexible robots are widely used in space applications due to their quick response, lower energy consumption, lower overall mass and operation at high speed compared to conventional industrial rigid link robots. These robots are inherently flexible, so that the kinematics of flexible robots can't be solved with rigid body assumptions. The flexibility in links and joints affects end-point positioning accuracy of the robot. It is important to model the link kinematics with precision which in turn simplifies modelling of dynamics of flexible robots. The main objective of this paper is to evaluate the effect of link flexibility on a tip position of a single link robotic arm for a given motion. The joint is assumed to be rigid and only link flexibility is considered. The kinematics of flexible link problem is evaluated by Assumed Modes Method (AMM) using MAT LAB Programming. To evaluate the effect of link flexibility (with and without payload) of robotic arm, the normalized tip deviation is found for flexible link with respect to a rigid link. Finally, the limiting inertia for payload mass is found if the allowable tip deviation is 5%.

  15. Use of link to mammography screening information and link sharing strategies

    DEFF Research Database (Denmark)

    Mukai, Thomas; Bro, Flemming; Olesen, Frede;

    2011-01-01

    screening. In addition to this, GPs in group 2 received an e-mail with the link at the midpoint of the programme. In addition to what the other two groups received, group 3 received an e-mail with the link two days after the letter. A paper-based survey of the use of the link was conducted among the 330...... play a role. Although Danish general practitioners (GPs) use PCs with an internet connection in their clinics, the best link-sharing strategies remain unknown. Aim: To evaluate link-sharing strategies in relation to mammography screening. Methods: In connection with the mammography screening programme...... in Central Denmark Region, we constructed a website containing screening programme information for GPs. We inserted the link to this website in different media and divided the GPs into three groups: Group 1 received a letter prior to the screening event and an electronic test result after the...

  16. Link Analysis in the Mission Planning Lab

    Science.gov (United States)

    McCarthy, Jessica A.; Cervantes, Benjamin W.; Daugherty, Sarah C.; Arroyo, Felipe; Mago, Divyang

    2011-01-01

    The legacy communications link analysis software currently used at Wallops Flight Facility involves processes that are different for command destruct, radar, and telemetry. There is a clear advantage to developing an easy-to-use tool that combines all the processes in one application. Link Analysis in the Mission Planning Lab (MPL) uses custom software and algorithms integrated with Analytical Graphics Inc. Satellite Toolkit (AGI STK). The MPL link analysis tool uses pre/post-mission data to conduct a dynamic link analysis between ground assets and the launch vehicle. Just as the legacy methods do, the MPL link analysis tool calculates signal strength and signal- to-noise according to the accepted processes for command destruct, radar, and telemetry assets. Graphs and other custom data are generated rapidly in formats for reports and presentations. STK is used for analysis as well as to depict plume angles and antenna gain patterns in 3D. The MPL has developed two interfaces with the STK software (see figure). The first interface is an HTML utility, which was developed in Visual Basic to enhance analysis for plume modeling and to offer a more user friendly, flexible tool. A graphical user interface (GUI) written in MATLAB (see figure upper right-hand corner) is also used to quickly depict link budget information for multiple ground assets. This new method yields a dramatic decrease in the time it takes to provide launch managers with the required link budgets to make critical pre-mission decisions. The software code used for these two custom utilities is a product of NASA's MPL.

  17. Publishing Data on Physical Samples Using the GeoLink Ontology and Linked Data Platforms

    Science.gov (United States)

    Ji, P.; Arko, R. A.; Lehnert, K. A.; Song, L.; Carter, M. R.; Hsu, L.

    2015-12-01

    Interdisciplinary Earth Data Alliance (IEDA), one of partners in EarthCube GeoLink project, seeks to explore the extent to which the use of GeoLink reusable Ontology Design Patterns (ODPs) and linked data platforms in IEDA data infrastructure can make research data more easily accessible and valuable. Linked data for the System for Earth Sample Registration (SESAR) is the first effort of IEDA to show how linked data enhance the presentation of IEDA data system architecture. SESAR Linked Data maps each table and column in SESAR database to RDF class and property based on GeoLink view, which build on the top of GeoLink ODPs. Then, uses D2RQ dumping the contents of SESAR database into RDF triples on the basis of mapping results. And, the dumped RDF triples is loaded into GRAPHDB, an RDF graph database, as permanent data in the form of atomic facts expressed as subjects, predicates and objects which provide support for semantic interoperability between IEDA and other GeoLink partners. Finally, an integrated browsing and searching interface build on Callimachus, a highly scalable platform for publishing linked data, is introduced to make sense of data stored in triplestore. Drill down and through features are built in the interface to help users locating content efficiently. The drill down feature enables users to explore beyond the summary information in the instance list of a specific class and into the detail from the specific instance page. The drill through feature enables users to jump from one instance to another one by simply clicking the link of the latter nested in the former region. Additionally, OpenLayers map is embedded into the interface to enhance the attractiveness of the presentation of instance which has geospatial information. Furthermore, by linking instances in the SESAR datasets to matching or corresponding instances in external sets, the presentation has been enriched with additional information about related classes like person, cruise, etc.

  18. Japan Link Center (JaLC): link management and DOI assignment for Japanese electronic scholarly contents

    Science.gov (United States)

    Kato, Takafumi; Tsuchiya, Eri; Kubota, Soichi; Miyagawa, Yoshiyuki

    JST, cooperated with several national institutes, is currently developing “Japan Link Center”, which manages Japanese electronic scholarly contents (journal articles, books, dissertations etc.) in an integrated fashion using Digital Object Identifier (DOI). Japan Link Center will manage metadata and whereabouts information of the contents in the digital environment and provide domestic and international linking information, cite/cited information to activate dissemination of S&T information, furthermore, to strengthen transmission of S&T information from Japan. Japan Link Center is expected to be appointed as the 9th DOI registration agency (RA) in the world by the International DOI Foundation (IDF) this spring.

  19. Cross-linking chemistry of squid beak.

    Science.gov (United States)

    Miserez, Ali; Rubin, Daniel; Waite, J Herbert

    2010-12-01

    In stark contrast to most aggressive predators, Dosidicus gigas (jumbo squids) do not use minerals in their powerful mouthparts known as beaks. Their beaks instead consist of a highly sclerotized chitinous composite with incremental hydration from the tip to the base. We previously reported l-3,4-dihydroxyphenylalanine (dopa)-histidine (dopa-His) as an important covalent cross-link providing mechanical strengthening to the beak material. Here, we present a more complete characterization of the sclerotization chemistry and describe additional cross-links from D. gigas beak. All cross-links presented in this report share common building blocks, a family of di-, tri-, and tetra-histidine-catecholic adducts, that were separated by affinity chromatography and high performance liquid chromatography (HPLC) and identified by tandem mass spectroscopy and proton nuclear magnetic resonance ((1)H NMR). The data provide additional insights into the unusually high cross-link density found in mature beaks. Furthermore, we propose both a low molecular weight catechol, and peptidyl-dopa, to be sclerotization agents of squid beak. This appears to represent a new strategy for forming hard tissue in animals. The interplay between covalent cross-linking and dehydration on the graded properties of the beaks is discussed. PMID:20870720

  20. Cross-linking Chemistry of Squid Beak*

    Science.gov (United States)

    Miserez, Ali; Rubin, Daniel; Waite, J. Herbert

    2010-01-01

    In stark contrast to most aggressive predators, Dosidicus gigas (jumbo squids) do not use minerals in their powerful mouthparts known as beaks. Their beaks instead consist of a highly sclerotized chitinous composite with incremental hydration from the tip to the base. We previously reported l-3,4-dihydroxyphenylalanine (dopa)-histidine (dopa-His) as an important covalent cross-link providing mechanical strengthening to the beak material. Here, we present a more complete characterization of the sclerotization chemistry and describe additional cross-links from D. gigas beak. All cross-links presented in this report share common building blocks, a family of di-, tri-, and tetra-histidine-catecholic adducts, that were separated by affinity chromatography and high performance liquid chromatography (HPLC) and identified by tandem mass spectroscopy and proton nuclear magnetic resonance (1H NMR). The data provide additional insights into the unusually high cross-link density found in mature beaks. Furthermore, we propose both a low molecular weight catechol, and peptidyl-dopa, to be sclerotization agents of squid beak. This appears to represent a new strategy for forming hard tissue in animals. The interplay between covalent cross-linking and dehydration on the graded properties of the beaks is discussed. PMID:20870720

  1. Novel Link Adaptation Schemes for OFDM System

    Institute of Scientific and Technical Information of China (English)

    LEI Ming; CAI Peng; XU Yue-shan; ZHANG Ping

    2003-01-01

    Orthogonal Frequency Division Multiplexing (OFDM) is the most promising technique supporting the high data rate transmission. The combination of the link adaptation and OFDM can further increase the spectral efficiency. In this paper, we put forward two link adaptation schemes for OFDM system which have the advantages of both flexibility and practicability. Both of the two novel link adaptation schemes are based on the iterative mechanism to allocate the bit and power to subcarriers according to their channel gains and noisy levels which are assumed to be already known at the transmitter. The candidate modulation modes are determined freely before the link adaptation schemes are performed. The distinction between the two novel link adaptation schemes is that in the novel scheme A, the modulation mode is upgraded to the neighboring higher-order mode, while in the novel scheme B the modulation is upgraded to the genuine optimal mode. Therefore, the novel scheme A has the advantage of lower complexity and the novel scheme B has the advantage of higher spectral efficiency.

  2. Local Type Checking for Linked Data Consumers

    Directory of Open Access Journals (Sweden)

    Gabriel Ciobanu

    2013-07-01

    Full Text Available The Web of Linked Data is the cumulation of over a decade of work by the Web standards community in their effort to make data more Web-like. We provide an introduction to the Web of Linked Data from the perspective of a Web developer that would like to build an application using Linked Data. We identify a weakness in the development stack as being a lack of domain specific scripting languages for designing background processes that consume Linked Data. To address this weakness, we design a scripting language with a simple but appropriate type system. In our proposed architecture some data is consumed from sources outside of the control of the system and some data is held locally. Stronger type assumptions can be made about the local data than external data, hence our type system mixes static and dynamic typing. Throughout, we relate our work to the W3C recommendations that drive Linked Data, so our syntax is accessible to Web developers.

  3. A generalized theory of preferential linking

    Science.gov (United States)

    Hu, Haibo; Guo, Jinli; Liu, Xuan; Wang, Xiaofan

    2014-12-01

    There are diverse mechanisms driving the evolution of social networks. A key open question dealing with understanding their evolution is: How do various preferential linking mechanisms produce networks with different features? In this paper we first empirically study preferential linking phenomena in an evolving online social network, find and validate the linear preference. We propose an analyzable model which captures the real growth process of the network and reveals the underlying mechanism dominating its evolution. Furthermore based on preferential linking we propose a generalized model reproducing the evolution of online social networks, and present unified analytical results describing network characteristics for 27 preference scenarios. We study the mathematical structure of degree distributions and find that within the framework of preferential linking analytical degree distributions can only be the combinations of finite kinds of functions which are related to rational, logarithmic and inverse tangent functions, and extremely complex network structure will emerge even for very simple sublinear preferential linking. This work not only provides a verifiable origin for the emergence of various network characteristics in social networks, but bridges the micro individuals' behaviors and the global organization of social networks.

  4. Improving Frequent Link Failure Detection in VANET

    Directory of Open Access Journals (Sweden)

    M.Sakthi ganesh

    2013-04-01

    Full Text Available VANET technology integrates wireless cellular and ad hoc for seamless connectivity between vehicles. Vehicle ad-hoc networks (VANETs are systems that allow vehicles to communicate with each other. Wireless-vice can send information to nearby vehicles, and messages can be sent from one vehicle to another, so that the informationcan be spread throughout the city. In the network, there is a link failure very common due to the high mobility of nodes in the network region available. So what makes frequent link failure that packets do not reach the respective destinations. The mechanism proposed here establishes a kind of route discovery packet parallel to the real time application to be delivered to the destination, while minimizing losses. The main objective is to establish parallel paths during link failures scenarios for real-time applications to provide data to their destination safely. Recovery road parallel fixed temporary parallel path between nodes when link failure. The node beforethe link failure packet buffers, after setting the new parallel paths before the packets stored in the buffer via the destination newly created path.

  5. Flexible Linked Axes for multivariate data visualization.

    Science.gov (United States)

    Claessen, Jarry H T; van Wijk, Jarke J

    2011-12-01

    Multivariate data visualization is a classic topic, for which many solutions have been proposed, each with its own strengths and weaknesses. In standard solutions the structure of the visualization is fixed, we explore how to give the user more freedom to define visualizations. Our new approach is based on the usage of Flexible Linked Axes: The user is enabled to define a visualization by drawing and linking axes on a canvas. Each axis has an associated attribute and range, which can be adapted. Links between pairs of axes are used to show data in either scatter plot- or Parallel Coordinates Plot-style. Flexible Linked Axes enable users to define a wide variety of different visualizations. These include standard methods, such as scatter plot matrices, radar charts, and PCPs [11]; less well known approaches, such as Hyperboxes [1], TimeWheels [17], and many-to-many relational parallel coordinate displays [14]; and also custom visualizations, consisting of combinations of scatter plots and PCPs. Furthermore, our method allows users to define composite visualizations that automatically support brushing and linking. We have discussed our approach with ten prospective users, who found the concept easy to understand and highly promising. PMID:22034351

  6. On Wireless Link Scheduling and Flow Control

    CERN Document Server

    Gore, Ashutosh Deepak

    2008-01-01

    This thesis focuses on link scheduling in wireless mesh networks by taking into account physical layer characteristics. The assumption made throughout is that a packet is received successfully only if the Signal to Interference and Noise Ratio (SINR) at the receiver exceeds the communication threshold. The thesis also discusses the complementary problem of flow control. (1) We consider various problems on centralized link scheduling in Spatial Time Division Multiple Access (STDMA) wireless mesh networks. We motivate the use of spatial reuse as performance metric and provide an explicit characterization of spatial reuse. We propose link scheduling algorithms based on certain graph models (communication graph, SINR graph) of the network. Our algorithms achieve higher spatial reuse than that of existing algorithms, with only a slight increase in computational complexity. (2) We investigate random access algorithms in wireless networks. We assume that the receiver is capable of power-based capture and propose a s...

  7. Percolation of networks with directed dependency links

    CERN Document Server

    Niu, Dunbiao; Du, Minhui; Stanley, H Eugene; Hu, Yanqing

    2016-01-01

    The self-consistent probabilistic approach has proven itself powerful in studying the percolation behavior of interdependent or multiplex networks without tracking the percolation process through each cascading step. In order to understand how directed dependency links impact criticality, we employ this approach to study the percolation properties of networks with both undirected connectivity links and directed dependency links. We find that when a random network with a given degree distribution undergoes a second-order phase transition, the critical point and the unstable regime surrounding the second-order phase transition regime are determined by the proportion of nodes that do not depend on any other nodes. Moreover, we also find that the triple point and the boundary between first- and second-order transitions are determined by the proportion of nodes that depend on no more than one node. This implies that it is maybe general for multiplex network systems, some important properties of phase transitions c...

  8. Improving personalized link prediction by hybrid diffusion

    CERN Document Server

    Liu, Jin-Hu; Zhou, Tao

    2016-01-01

    Inspired by traditional link prediction and to solve the problem of recommending friends in social networks, we introduce the personalized link prediction in this paper, in which each individual will get equal number of diversiform predictions. While the performances of many classical algorithms are not satisfactory under this framework, thus new algorithms are in urgent need. Motivated by previous researches in other fields, we generalize heat conduction process to the framework of personalized link prediction and find that this method outperforms many classical similarity-based algorithms, especially in the performance of diversity. In addition, we demonstrate that adding one ground node who is supposed to connect all the nodes in the system will greatly benefit the performance of heat conduction. Finally, better hybrid algorithms composed of local random walk and heat conduction have been proposed. Numerical results show that the hybrid algorithms can outperform other algorithms simultaneously in all four ...

  9. Quantitative linking hypotheses for infant eye movements.

    Directory of Open Access Journals (Sweden)

    Daniel Yurovsky

    Full Text Available The study of cognitive development hinges, largely, on the analysis of infant looking. But analyses of eye gaze data require the adoption of linking hypotheses: assumptions about the relationship between observed eye movements and underlying cognitive processes. We develop a general framework for constructing, testing, and comparing these hypotheses, and thus for producing new insights into early cognitive development. We first introduce the general framework--applicable to any infant gaze experiment--and then demonstrate its utility by analyzing data from a set of experiments investigating the role of attentional cues in infant learning. The new analysis uncovers significantly more structure in these data, finding evidence of learning that was not found in standard analyses and showing an unexpected relationship between cue use and learning rate. Finally, we discuss general implications for the construction and testing of quantitative linking hypotheses. MATLAB code for sample linking hypotheses can be found on the first author's website.

  10. Editorial: Link Spam and Search Engines

    Directory of Open Access Journals (Sweden)

    Alireza Noruzi

    2006-03-01

    Full Text Available The growing number of blogs has caused problems for search engines, problems such as the highly frequent blog spam. Spammers use blogs to promote their websites. Spammers are trying to win the attention of search engines, not of bloggers or their readers. Link spam dishonestly and deliberately manipulates link-based ranking algorithms of search engines like Google's PageRank to increase the rank of a web site or page so that it is placed as close to the top of search results as possible. A link-based ranking algorithm gives a higher ranking to a site that has many backlinks, especially from highly-ranked sites/pages.

  11. Why should we publish Linked Data?

    Science.gov (United States)

    Blower, Jon; Riechert, Maik; Koubarakis, Manolis; Pace, Nino

    2016-04-01

    We use the Web every day to access information from all kinds of different sources. But the complexity and diversity of scientific data mean that discovering accessing and interpreting data remains a large challenge to researchers, decision-makers and other users. Different sources of useful information on data, algorithms, instruments and publications are scattered around the Web. How can we link all these things together to help users to better understand and exploit earth science data? How can we combine scientific data with other relevant data sources, when standards for describing and sharing data vary so widely between communities? "Linked Data" is a term that describes a set of standards and "best practices" for sharing data on the Web (http://www.w3.org/standards/semanticweb/data). These principles can be summarised as follows: 1. Create unique and persistent identifiers for the important "things" in a community (e.g. datasets, publications, algorithms, instruments). 2. Allow users to "look up" these identifiers on the web to find out more information about them. 3. Make this information machine-readable in a community-neutral format (such as RDF, Resource Description Framework). 4. Within this information, embed links to other things and concepts and say how these are related. 5. Optionally, provide web service interfaces to allow the user to perform sophisticated queries over this information (using a language such as SPARQL). The promise of Linked Data is that, through these techniques, data will be more discoverable, more comprehensible and more usable by different communities, not just the community that produced the data. As a result, many data providers (particularly public-sector institutions) are now publishing data in this way. However, this area is still in its infancy in terms of real-world applications. Data users need guidance and tools to help them use Linked Data. Data providers need reassurance that the investments they are making in

  12. Discovering and Mining Links for Protein Databases

    Directory of Open Access Journals (Sweden)

    A.Immaculate Mercy

    2014-01-01

    Full Text Available This work introduces a link analysis procedure for discovering relationships in a protein database or a relational database generalizing simple correspondence analysis. It is based on extracting the links to the rela ted protein database and malfunctioned protein database. The datasets are trained in order to find out missing interactions and the sequences related to them. Further the analysis of links proceeds by performing a random walk defining a Markov chain. The e lements of interest are analysed through stochastic complementation which gives a reduced Markov chain. This reduced map is then analysed by projecting the elements of interest through Principal component analysis. Several Protein datasets are analysed using the proposed methodology, showing the usefulness of the technique for extracting relationships in relational databases or graphs.

  13. Influence of Reciprocal links in Social Networks

    CERN Document Server

    Zhu, Yu-Xiao; Sun, Gui-Quan; Tang, Ming; Zhou, Tao; Zhang, Zi-Ke

    2013-01-01

    In this Letter, we empirically study the influence of reciprocal links, in order to understand its role in affecting the structure and function of directed social networks. Experimental results on two representative datesets, Sina Weibo and Douban, demonstrate that the reciprocal links indeed play a more important role than non-reciprocal ones in both spreading information and maintaining the network robustness. In particular, the information spreading process can be significantly enhanced by considering the reciprocal effect. In addition, reciprocal links are largely responsible for the connectivity and efficiency of directed networks. This work may shed some light on the in-depth understanding and application of the reciprocal effect in directed online social networks.

  14. Discovering and Mining Links for Protein Databases

    Directory of Open Access Journals (Sweden)

    A. Immaculate Mercy

    2015-10-01

    Full Text Available link analysis procedure for discovering relationships in a protein database or a relational database generalizing simple correspondence analysis. It is based on extracting the links to the related protein database and malfunctioned protein database. The datasets are trained in order to find out missing interactions and the sequences related to them. Further the analysis of links proceeds by performing a random walk defining a Markov chain. The elements of interest are analysed through stochastic complementation which gives a reduced Markov chain. This reduced map is then analysed by projecting the elements of interest through Principal component analysis. Several Protein datasets are analysed using the proposed methodology, showing the usefulness of the technique for extracting relationships in relational databases or graphs.

  15. Genetics Home Reference: X-linked sideroblastic anemia

    Science.gov (United States)

    ... Conditions X-linked sideroblastic anemia X-linked sideroblastic anemia Enable Javascript to view the expand/collapse boxes. ... Open All Close All Description X-linked sideroblastic anemia is an inherited disorder that prevents developing red ...

  16. Genetics Home Reference: X-linked severe combined immunodeficiency

    Science.gov (United States)

    ... Health Conditions X-linked SCID X-linked severe combined immunodeficiency Enable Javascript to view the expand/collapse ... Open All Close All Description X-linked severe combined immunodeficiency (SCID) is an inherited disorder of the ...

  17. Urban rainfall estimation employing commercial microwave links

    Science.gov (United States)

    Overeem, Aart; Leijnse, Hidde; Uijlenhoet, Remko; ten Veldhuis, Marie-claire

    2015-04-01

    Urban areas often lack rainfall information. To increase the number of rainfall observations in cities, microwave links from operational cellular telecommunication networks may be employed. Although this new potential source of rainfall information has been shown to be promising, its quality needs to be demonstrated more extensively. In the Rain Sense kickstart project of the Amsterdam Institute for Advanced Metropolitan Solutions (AMS), sensors and citizens are preparing Amsterdam for future weather. Part of this project is rainfall estimation using new measurement techniques. Innovative sensing techniques will be utilized such as rainfall estimation from microwave links, umbrellas for weather sensing, low-cost sensors at lamp posts and in drainage pipes for water level observation. These will be combined with information provided by citizens in an active way through smartphone apps and in a passive way through social media posts (Twitter, Flickr etc.). Sensor information will be integrated, visualized and made accessible to citizens to help raise citizen awareness of urban water management challenges and promote resilience by providing information on how citizens can contribute in addressing these. Moreover, citizens and businesses can benefit from reliable weather information in planning their social and commercial activities. In the end city-wide high-resolution rainfall maps will be derived, blending rainfall information from microwave links and weather radars. This information will be used for urban water management. This presentation focuses on rainfall estimation from commercial microwave links. Received signal levels from tens of microwave links within the Amsterdam region (roughly 1 million inhabitants) in the Netherlands are utilized to estimate rainfall with high spatial and temporal resolution. Rainfall maps will be presented and compared to a gauge-adjusted radar rainfall data set. Rainfall time series from gauge(s), radars and links will be compared.

  18. Link prediction via generalized coupled tensor factorisation

    DEFF Research Database (Denmark)

    Ermiş, Beyza; Evrim, Acar Ataman; Taylan Cemgil, A.

    2012-01-01

    and higher-order tensors. We propose to use an approach based on probabilistic interpretation of tensor factorisation models, i.e., Generalised Coupled Tensor Factorisation, which can simultaneously fit a large class of tensor models to higher-order tensors/matrices with com- mon latent factors using...... different loss functions. Numerical experiments demonstrate that joint analysis of data from multiple sources via coupled factorisation improves the link prediction performance and the selection of right loss function and tensor model is crucial for accurately predicting missing links....

  19. Microwave line of sight link engineering

    CERN Document Server

    Angueira, Pablo

    2012-01-01

    A comprehensive guide to the design, implementation, and operation of line of sight microwave link systems The microwave Line of Sight (LOS) transport network of any cellular operator requires at least as much planning effort as the cellular infrastructure itself. The knowledge behind this design has been kept private by most companies and has not been easy to find. Microwave Line of Sight Link Engineering solves this dilemma. It provides the latest revisions to ITU reports and recommendations, which are not only key to successful design but have changed dramatically in

  20. SPARQL Query Result Explanation for Linked Data

    OpenAIRE

    Hasan, Rakebul; Endris, Kemele M.; Gandon, Fabien

    2014-01-01

    In this paper, we present an approach to explain SPARQL query results for Linked Data using why-provenance. We present a non-annotation-based algorithm to generate why-provenance and show its feasibility for Linked Data. We present an explanation-aware federated query processor prototype and show the presentation of our explanations. We present a user study to evaluate the impacts of our explanations. Our study shows that our query result explanations are helpful for end users to understand t...

  1. Service Migration Protocol for NFC Links

    DEFF Research Database (Denmark)

    Nickelsen, Anders; Schwefel, Hans-Peter; Martin, Miquel

    2010-01-01

    In future ubiquitous communication environments, users expect to move freely while continuously interacting with the available applications through a variety of devices. Interactive applications will therefore need to support migration, which means to follow users and adapt to the changing context...... of use while preserving state. This paper focuses on the scenario of migration between two devices in which the actual migration procedure is executed over near-field communication (NFC) ad-hoc links. The NFC link is interesting as it gives the user the perception of trust and enables service...... on the sizes of application state that can be expected to be feasible for such ad-hoc NFC migration....

  2. Editorial: Link Spam and Search Engines

    OpenAIRE

    Alireza Noruzi

    2006-01-01

    The growing number of blogs has caused problems for search engines, problems such as the highly frequent blog spam. Spammers use blogs to promote their websites. Spammers are trying to win the attention of search engines, not of bloggers or their readers. Link spam dishonestly and deliberately manipulates link-based ranking algorithms of search engines like Google's PageRank to increase the rank of a web site or page so that it is placed as close to the top of search results as possible. A li...

  3. Approximate Semantic Matching Over Linked Data Streams

    OpenAIRE

    Qin, Yongrui; Yao, Lina; Sheng, Quan Z.

    2016-01-01

    In the Internet of Things (IoT),data can be generated by all kinds of smart things. In such context, enabling machines to process and understand such data is critical. Semantic Web technologies, such as Linked Data, provide an effective and machine-understandable way to represent IoT data for further processing. It is a challenging issue to match Linked Data streams semantically based on text similarity as text similarity computation is time consuming. In this paper, we present a hashing-base...

  4. Macromolecular Flexibility and Aggregation Tendency of Non-Cross-Linked and Cross-Linked Cationic Polysoaps

    NARCIS (Netherlands)

    Wang, Guang-Jia; Engberts, Jan B.F.N.

    1998-01-01

    The aggregation tendency of non-cross-linked and cross-linked poly(alkylmethyl-diallylammonium halides) bearing n-dodecyl and n-decyl side chains ((CL)-CopolC1-12-Cl, (CL)-CopolC1-12-Br and (CL)-CopolC1-10-Br, respectively) in aqueous solution has been evaluated by measuring their critical aggregate

  5. FormLink/FeynCalcFormLink : Embedding FORM in Mathematica and FeynCalc

    CERN Document Server

    Feng, Feng

    2012-01-01

    FORM, a symbolic manipulation system, has been widely used in a lot of calculations for High Energy Physics due to its high performance and fficient design. Mathematica, another computational software program, has also widely been used, but more for reasons of generality and user-friendliness than for speed. Especially calculations involving tensors and noncommutative operations like calculating Dirac traces can be rather slow in Mathematica, compared to FORM. In this article we describe FormLink and FeynCalcFormLink, two Mathematica packages to link Mathematica and FeynCalc with FORM. FormLink can be used without FeynCalc and FeynCalcFormLink, which is an extension loading FormLink and FeynCalc automatically. With these two packages the impressive speed and other special features of FORM get embedded into the generality of Mathematica and FeynCalc in a simple manner. FeynCalcFormLink provides a FORM-based turbo for FeynCalc, making it much more efficient. FormLink turns Mathematica into an editor and code or...

  6. DC-Link Compensation Method for Slim DC Link Drives Fed by Soft Grid

    DEFF Research Database (Denmark)

    Mathe, Laszlo; Rosendahl Andersen, Henrik; Lazar, Radu;

    2010-01-01

    Slim DC-link PWM (AC) drives for lowperformance applications are emerging on the market. Such drives equipped with a small DC-link capacitance exhibit instability tendencies, if installed on a soft line, giving a degraded performance. The total harmonic distortion (THD) and the partially weighted...... harmonic distortion (PWHD) of the line current are degraded, if resonance between the line impedance and the DC-link capacitance occurs. Likewise, the motor performance is affected negatively giving extra torque ripple, vibration and acoustic-noise emission. This paper proposes a novel DC-link compensation...... method, which ensures the stability of the slim DC-link on a soft grid. The proposed compensation method may be used for open- and closedloop control schemes, requiring a small overhead in the digital implementation....

  7. Linked data for libraries, archives and museums how to clean, link and publish your metadata

    CERN Document Server

    Hooland, Seth van

    2014-01-01

    This highly practical handbook teaches you how to unlock the value of your existing metadata through cleaning, reconciliation, enrichment and linking and how to streamline the process of new metadata creation. Libraries, archives and museums are facing up to the challenge of providing access to fast growing collections whilst managing cuts to budgets. Key to this is the creation, linking and publishing of good quality metadata as Linked Data that will allow their collections to be discovered, accessed and disseminated in a sustainable manner. This highly practical handbook teaches you how to unlock the value of your existing metadata through cleaning, reconciliation, enrichment and linking and how to streamline the process of new metadata creation. Metadata experts Seth van Hooland and Ruben Verborgh introduce the key concepts of metadata standards and Linked Data and how they can be practically applied to existing metadata, giving readers the tools and understanding to achieve maximum results with limited re...

  8. Auditing Dynamic Links to Online Information Resources

    Science.gov (United States)

    Li, Jianhua; Cimino, James J.

    2007-01-01

    The Columbia University Infobutton Manager (IM) is a system that provides dynamically generated, context-specific links between clinical information systems and online information resources. The resources range from local documents, to commercially available document sets and search engines. The links provided by the IM can be reliably created, but there is no guarantee that they will function reliably, since the resources to which they point are subject to unannounced changes and failures. We have developed a set of tools to audit the links periodically to determine if the resources are available and if the IM has sufficient information to generate all the links needed by its users. These tools have been in use since February, 2006 and have provided timely warnings on many occasions. These warnings have allowed us to correct problems with resource access before they became apparent to our users and often before the resource maintainers were aware of the problems. The tools have thus helped us provide clinicians with a dependable level of service. PMID:18693876

  9. Linking Individual Creativity to Organizational Innovation

    Science.gov (United States)

    Litchfield, Robert C.; Ford, Cameron M.; Gentry, Richard J.

    2015-01-01

    We draw on 146 employee-co-worker-supervisor triads from 146 organizations to examine the role of individual perspective-taking and team creative environment in the association between individual creativity and organizational innovation. Adopting an interactionist perspective, we find that the link between individual creativity and organizational…

  10. Link Enhancer for Vehicular Wireless ATM Communications

    CERN Document Server

    Arun Kumar, S P; Kumar, Amrendra

    2008-01-01

    Majority of the applications used in defense are voice, video and data oriented and has strict QoS requirements. One of the technologies that enabled this is Asynchronous Transfer Mode (ATM) networking. Traditional ATM networks are wired networks. But Tactical networks are meant to be mobile and this necessitates the use of radio relays for Vehicle-to-Infrastructure (V2I) and Vehicle-to-Vehicle (V2V) communications. ATM networks assume a physical link layer BER of 10^-9 or better because of the availability of reliable media like optical fiber links. But this assumption is no longer valid when ATM switches are connected through radio relay where error rates are in the rage of 10^-3. This paper presents the architecture of a Link Enhancer meant to improve the Bit Error Rate of the Wireless links used for V2I and V2V communications from 1 in 10^4 to 1 in 10^8

  11. Highly-Concurrent Doubly-Linked Lists

    CERN Document Server

    Garg, Nitin; Botelho, Fabiano C

    2011-01-01

    As file systems are increasingly being deployed on ever larger systems with many cores and multi-gigabytes of memory, scaling the internal data structures of file systems has taken greater importance and urgency. A doubly-linked list is a simple and very commonly used data structure in file systems but it is not very friendly to multi-threaded use. While special cases of lists, such as queues and stacks, have lock-free versions that scale reasonably well, the general form of a doubly-linked list offers no such solution. Using a mutex to serialize all operations remains the de-facto method of maintaining a doubly linked list. This severely limits the scalability of the list and developers must resort to ad-hoc workarounds that involve using multiple smaller lists (with individual locks) and deal with the resulting complexity of the system. In this paper, we present an approach to building highly concurrent data structures, with special focus on the implementation of highly concurrent doubly-linked lists. Dubbe...

  12. LODE: Linking Open Descriptions of Events

    NARCIS (Netherlands)

    Shaw, R.; Troncy, R.; Hardman, L.

    2009-01-01

    People conventionally refer to an action or occurrence taking place at a certain time at a specific location as an event. This notion is potentially useful for connecting individual facts recorded in the rapidly growing collection of linked data sets and for discovering more complex relationships be

  13. A gigabit ethernet link source card.

    Energy Technology Data Exchange (ETDEWEB)

    Blair, R. E.; Dawson, J. W.; Drake, G.; Haberichter, W. N.; Schlereth, J. L.

    2002-09-18

    A Link Source Card (LSC) has been developed which employs Gigabit Ethernet as the physical medium. The LSC is implemented as a mezzanine card compliant with the S-Link specifications, and is intended for use in development of the Region of Interest Building (ROIB) in the Level 2 Trigger of ATLAS. The LSC will be used to bring Region of Internet Fragments from Level 1 Trigger elements to the ROIB, and to transfer compiled Region of Interest Records to Supervisor Processors. The card uses the LSI 8101/8104 Media Access Controller (MAC) [1] and the Agilent HDMP-1636 Transceiver. An Altera 10K50A FPGA [2] is configured to provide several state machines which perform all the tasks on the card, such as formulating the Ethernet header, read/write registers in the MAC, etc. An on-card static RAM provides storage for 512K S-Link words, and a FIFO provides 4K buffering of input S-Link words. The LSC has been tested in a setup where it transfers data to a NIC in the PCI bus of a PC.

  14. Analysis Links Zoning Policies and Disparities

    Science.gov (United States)

    Shah, Nirvi

    2012-01-01

    Location, location, location. This mantra of real estate agents and their clients alike is now the target of a new report from the Brookings Institution linking housing prices and zoning practices to effectively depriving low-income students of high-quality schools. Using test scores from schools in the 100 largest metropolitan areas in the…

  15. A gigabit ethernet link source card

    International Nuclear Information System (INIS)

    A Link Source Card (LSC) has been developed which employs Gigabit Ethernet as the physical medium. The LSC is implemented as a mezzanine card compliant with the S-Link specifications, and is intended for use in development of the Region of Interest Building (ROIB) in the Level 2 Trigger of ATLAS. The LSC will be used to bring Region of Internet Fragments from Level 1 Trigger elements to the ROIB, and to transfer compiled Region of Interest Records to Supervisor Processors. The card uses the LSI 8101/8104 Media Access Controller (MAC) [1] and the Agilent HDMP-1636 Transceiver. An Altera 10K50A FPGA [2] is configured to provide several state machines which perform all the tasks on the card, such as formulating the Ethernet header, read/write registers in the MAC, etc. An on-card static RAM provides storage for 512K S-Link words, and a FIFO provides 4K buffering of input S-Link words. The LSC has been tested in a setup where it transfers data to a NIC in the PCI bus of a PC

  16. Cross-linked structure of network evolution

    Energy Technology Data Exchange (ETDEWEB)

    Bassett, Danielle S., E-mail: dsb@seas.upenn.edu [Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Department of Physics, University of California, Santa Barbara, California 93106 (United States); Sage Center for the Study of the Mind, University of California, Santa Barbara, California 93106 (United States); Wymbs, Nicholas F.; Grafton, Scott T. [Department of Psychology and UCSB Brain Imaging Center, University of California, Santa Barbara, California 93106 (United States); Porter, Mason A. [Oxford Centre for Industrial and Applied Mathematics, Mathematical Institute, University of Oxford, Oxford OX2 6GG (United Kingdom); CABDyN Complexity Centre, University of Oxford, Oxford, OX1 1HP (United Kingdom); Mucha, Peter J. [Carolina Center for Interdisciplinary Applied Mathematics, Department of Mathematics, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Department of Applied Physical Sciences, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)

    2014-03-15

    We study the temporal co-variation of network co-evolution via the cross-link structure of networks, for which we take advantage of the formalism of hypergraphs to map cross-link structures back to network nodes. We investigate two sets of temporal network data in detail. In a network of coupled nonlinear oscillators, hyperedges that consist of network edges with temporally co-varying weights uncover the driving co-evolution patterns of edge weight dynamics both within and between oscillator communities. In the human brain, networks that represent temporal changes in brain activity during learning exhibit early co-evolution that then settles down with practice. Subsequent decreases in hyperedge size are consistent with emergence of an autonomous subgraph whose dynamics no longer depends on other parts of the network. Our results on real and synthetic networks give a poignant demonstration of the ability of cross-link structure to uncover unexpected co-evolution attributes in both real and synthetic dynamical systems. This, in turn, illustrates the utility of analyzing cross-links for investigating the structure of temporal networks.

  17. Extracting Macroscopic Information from Web Links.

    Science.gov (United States)

    Thelwall, Mike

    2001-01-01

    Discussion of Web-based link analysis focuses on an evaluation of Ingversen's proposed external Web Impact Factor for the original use of the Web, namely the interlinking of academic research. Studies relationships between academic hyperlinks and research activities for British universities and discusses the use of search engines for Web link…

  18. A link between inflammation and metastasis

    DEFF Research Database (Denmark)

    Hansen, M. T.; Forst, B.; Cremers, N.;

    2015-01-01

    S100A4 is implicated in metastasis and chronic inflammation, but its function remains uncertain. Here we establish an S100A4-dependent link between inflammation and metastatic tumor progression. We found that the acute-phase response proteins serum amyloid A (SAA) 1 and SAA3 are transcriptional t...

  19. Linking Large-Scale Reading Assessments: Comment

    Science.gov (United States)

    Hanushek, Eric A.

    2016-01-01

    E. A. Hanushek points out in this commentary that applied researchers in education have only recently begun to appreciate the value of international assessments, even though there are now 50 years of experience with these. Until recently, these assessments have been stand-alone surveys that have not been linked, and analysis has largely focused on…

  20. Testing transitivity of preferences using linked designs

    Directory of Open Access Journals (Sweden)

    Michael H. Birnbaum

    2012-09-01

    Full Text Available Three experiments tested if individuals show violations of transitivity in choices between risky gambles in linked designs. The binary gambles varied in the probability to win the higher (better prize, the value of the higher prize, and the value of the lower prize. Each design varied two factors, with the third fixed. Designs are linked by using the same values in different designs. Linked designs allow one to determine if a lexicographic semiorder model can describe violations of transitivity in more than one design using the same parameters. In addition, two experiments tested interactive independence, a critical property implied by all lexicographic semiorder models. Very few people showed systematic violations of transitivity; only one person out of 136 showed violations of transitivity in two designs that could be linked by a lexicographic semiorder. However, that person violated interactive independence, as did the majority of other participants. Most individuals showed systematic violations of the assumptions of stochastic independence and stationarity of choice responses. That means that investigators should evaluate models with respect to response patterns (response combinations rather than focusing entirely on choice proportions.

  1. Linking algal growth inhibition to chemical activity

    DEFF Research Database (Denmark)

    Schmidt, Stine N.; Mayer, Philipp

    chemical activity, as opposed to e.g. the total concentration. Baseline toxicity (narcosis) for neutral hydrophobic organic compounds has been shown to initiate in the narrow chemical activity range of 0.01 to 0.1. This presentation focuses on linking algal growth inhibition to chemical activity with the...

  2. Multi-level slip-link modeling

    Science.gov (United States)

    Schieber, Jay

    2014-03-01

    That the dynamics of concentrated, high-molecular-weight polymers are largely governed by entanglements is now widely accepted, and typically understood by the tube model. Although the original idea for slip-links was proposed at the same time as tubes, only recently have detailed, quantitative mathematical models arisen based on this picture. We argue here for the use of a slip-link model that has strong connections to atomistic, multichain levels of description, agrees with non-equilibrium thermodynamics, applies to any chain architecture and can be used in linear or non-linear rheology. We present a hierarchy of slip-link models that are connected to each other through successive coarse graining. One might choose a particular member of the hierarchy depending on the problem at hand, in order to minimize computational effort. In particular, the most detailed level of description has four parameters, three of which can be determined directly from atomistic simulations. The least-detailed member is suitable for predicting non-linear, non-uniform flow fields. We will show how using this hierarchy of slip-link models we can make predictions about the nonlinear rheology of monodisperse homopolymer melts, polydisperse melts, or blends of different architectures.

  3. Sharp Connection: Linking Competitive Intelligence and Intranets

    NARCIS (Netherlands)

    Hendriks, P.H.J.; Jacobs, W.H.

    2003-01-01

    Assessing the value of ICT to support Competitive Intelligence presumes an understanding of the relationship between the two. The chapter argues that starting from either the ICT or CI side to this relationship and linking to the other, as most studies do, cannot secure a fully adequate conception o

  4. Using and detecting links in Wikipedia

    NARCIS (Netherlands)

    K.N. Fachry; J. Kamps; M. Koolen; J. Zhang

    2007-01-01

    In this paper, we document our efforts at INEX 2007 where we participated in the Ad Hoc Track, the Link the Wiki Track, and the Interactive Track that continued from INEX 2006. Our main aims at INEX 2007 were the following. For the Ad Hoc Track, we investigated the effectiveness of incorporating lin

  5. Cross-linked structure of network evolution

    International Nuclear Information System (INIS)

    We study the temporal co-variation of network co-evolution via the cross-link structure of networks, for which we take advantage of the formalism of hypergraphs to map cross-link structures back to network nodes. We investigate two sets of temporal network data in detail. In a network of coupled nonlinear oscillators, hyperedges that consist of network edges with temporally co-varying weights uncover the driving co-evolution patterns of edge weight dynamics both within and between oscillator communities. In the human brain, networks that represent temporal changes in brain activity during learning exhibit early co-evolution that then settles down with practice. Subsequent decreases in hyperedge size are consistent with emergence of an autonomous subgraph whose dynamics no longer depends on other parts of the network. Our results on real and synthetic networks give a poignant demonstration of the ability of cross-link structure to uncover unexpected co-evolution attributes in both real and synthetic dynamical systems. This, in turn, illustrates the utility of analyzing cross-links for investigating the structure of temporal networks

  6. Improving personalized link prediction by hybrid diffusion

    Science.gov (United States)

    Liu, Jin-Hu; Zhu, Yu-Xiao; Zhou, Tao

    2016-04-01

    Inspired by traditional link prediction and to solve the problem of recommending friends in social networks, we introduce the personalized link prediction in this paper, in which each individual will get equal number of diversiform predictions. While the performances of many classical algorithms are not satisfactory under this framework, thus new algorithms are in urgent need. Motivated by previous researches in other fields, we generalize heat conduction process to the framework of personalized link prediction and find that this method outperforms many classical similarity-based algorithms, especially in the performance of diversity. In addition, we demonstrate that adding one ground node that is supposed to connect all the nodes in the system will greatly benefit the performance of heat conduction. Finally, better hybrid algorithms composed of local random walk and heat conduction have been proposed. Numerical results show that the hybrid algorithms can outperform other algorithms simultaneously in all four adopted metrics: AUC, precision, recall and hamming distance. In a word, this work may shed some light on the in-depth understanding of the effect of physical processes in personalized link prediction.

  7. Spherical structures on torus knots and links

    OpenAIRE

    Kolpakov, Alexander; Mednykh, Alexander

    2010-01-01

    The present paper considers two infinite families of cone-manifolds endowed with spherical metric. The singular strata is either the torus knot ${\\rm t}(2n+1, 2)$ or the torus link ${\\rm t}(2n, 2)$. Domains of existence for a spherical metric are found in terms of cone angles and volume formul{\\ae} are presented.

  8. Quilts and Tangrams: Linking Literature and Geometry.

    Science.gov (United States)

    Bohning, Gerry; Williams, Rebecca

    1997-01-01

    Suggests that by making quilt squares with tangrams, children link geometry and children's literature. Provides background on quilts and tangrams, and provides guidelines for teachers. Points out that children gain communication and mathematical thinking skills as they manipulate and explore relationships among pieces. Contains an annotated…

  9. La LC classification come linked data

    Directory of Open Access Journals (Sweden)

    Kevin Ford

    2013-01-01

    Full Text Available In 2009 and in 2011, the Library of Congress made two of its largest authority files – Subject Headings and Names – available as linked data via LC’s Linked Data Service, ID.LOC.GOV. Both are offered in MADS/RDF and SKOS. It is LC’s objective, in 2012, to publish another of its largest authority files as linked data: LC Classification. Whereas the source records for Subject Headings and Names are encoded in the MARC Authority format, from which there is a relatively straightforward mapping to MADS/RDF and SKOS, LC Classification records rely on the MARC Classification format. Mapping from LC Classification to MADS/RDF or SKOS has been a little more challenging. For example, records that represent classification ranges, which are not Concepts intended to be assigned, are not easily accommodated in SKOS. This presents additional problems when needing to accurately represent the relationships in RDF for LC Classification. With comparison to the publication of LCSH and Names at ID.LOC.GOV, this paper will examine issues encountered – and how those challenges were addressed – during the conversion of LC Classification to MADS/RDF and SKOS for release as linked data at ID.LOC.GOV.

  10. Pseudo-Equivalent Groups and Linking

    Science.gov (United States)

    Haberman, Shelby J.

    2015-01-01

    Adjustment by minimum discriminant information provides an approach to linking test forms in the case of a nonequivalent groups design with no satisfactory common items. This approach employs background information on individual examinees in each administration so that weighted samples of examinees form pseudo-equivalent groups in the sense that…

  11. Using Linked Data in Learning Analytics

    NARCIS (Netherlands)

    d'Aquin, Mathieu; Dietze, Stefan; Herder, Eelco; Drachsler, Hendrik; Taibi, David

    2014-01-01

    Learning Analytics has a lot to do with data, and the way to make sense of raw data in terms of the learner’s experience, behaviour and knowledge. In this article, we argue about the need for a closer relationship between the field of Learning Analytics and the one of Linked Data, which in our view

  12. Inter-satellite links for cubesats

    NARCIS (Netherlands)

    Budianu, A.; Castro, T.J.W.; Meijerink, A.; Bentum, M.J.

    2013-01-01

    Realizing inter-satellite links is a must for ensuring the success of cubesat swarm missions. Nevertheless, it has hardly been considered until now. The communication systems for cubesats have to deal with a few peculiar demands regarding consumed power, geometry and throughput. Depending on the typ

  13. The Missing Link: Research on Teacher Education

    Science.gov (United States)

    Wiens, Peter D.

    2012-01-01

    Teacher education has recently come under attack for its perceived lack of efficacy in preparing teachers for classroom duty. A lack of comprehensive research in teacher education makes it difficult to understand the effects of teacher education programs on student learning. There is a missing link between what happens in teacher education…

  14. Benchmarking Linked Open Data Management Systems

    NARCIS (Netherlands)

    Angles Rojas, R.; Pham, M.D.; Boncz, P.A.

    2014-01-01

    With inherent support for storing and analysing highly interconnected data, graph and RDF databases appear as natural solutions for developing Linked Open Data applications. However, current benchmarks for these database technologies do not fully attain the desirable characteristics in industrial-st

  15. A Verified Algebra for Linked Data

    Directory of Open Access Journals (Sweden)

    Ross Horne

    2011-07-01

    Full Text Available A foundation is investigated for the application of loosely structured data on the Web. This area is often referred to as Linked Data, due to the use of URIs in data to establish links. This work focuses on emerging W3C standards which specify query languages for Linked Data. The approach is to provide an abstract syntax to capture Linked Data structures and queries, which are then internalised in a process calculus. An operational semantics for the calculus specifies how queries, data and processes interact. A labelled transition system is shown to be sound with respect to the operational semantics. Bisimulation over the labelled transition system is used to verify an algebra over queries. The derived algebra is a contribution to the application domain. For instance, the algebra may be used to rewrite a query to optimise its distribution across a cluster of servers. The framework used to provide the operational semantics is powerful enough to model related calculi for the Web.

  16. Facilitating Collaboration Through Linked Open Data

    Science.gov (United States)

    Narock, T. W.; Rozell, E. A.; Robinson, E. M.

    2012-12-01

    The increasing volumes, complexity, and heterogeneity of scientific data are requiring members of formally disparate disciplines to come together to address today's scientific challenges. Data science is formed at the intersection of domain scientists, information specialists, librarians, computer scientists and data managers. With such a distributed and diverse community, it can be difficult to identify collaborators, keep track of current research, and assess the underlying social network. We introduce the notion of data science within the Earth and space sciences and present a novel tool for understanding the evolving research network. Linked Data, a modern paradigm for data publishing, leverages the inherent linking capabilities of the Web. Additionally, Linked Data is a machine understandable data format that enables computational reasoning and inferencing. Using this concept, we have linked data from a number of disparate sources such as, hundreds of thousands of AGU abstracts, National Science Foundation project information, people, and organizations. We highlight new collaborations and insights enabled by visualizing the relationships between publications, science data, people, organizations, and events and discuss how such an approach can benefit with extensions from the community at large.

  17. Data Link Layer Protocol Simulator User Guide

    OpenAIRE

    Nataf, Emmanuel

    2008-01-01

    The data link layer protocol simulator allows to write protocol and to see them in execution. This guide describes a step by step approach from simple information communication without any control to windows protocols. A protocol oriented java API is defined to write protocol algorithms.

  18. INTERNATIONAL MIGRATION LINKS OF SVERDLOVSK REGION

    OpenAIRE

    Nosov, A.

    2011-01-01

    The complex of migration links of Sverdlovsk region is considered in the article. The analysis of position of the region in the migration structure of Russian Federation and the Ural Federal district is presented based on the available literature data. An estimate of dynamics of migration processes in Sverdlovsk region is given.

  19. Linking quality goals and product development competences

    DEFF Research Database (Denmark)

    Olsen, Johanne Rønnow; Harmsen, Hanne; Friis, Alan

    2008-01-01

    orientation influence the way product development is performed. The aim of this paper is to investigate managerial quality goals and how these may be linked to product development competences, which has not previously been studied. The study draws on an empirical, qualitative study in the Danish food industry...

  20. Visualizing Transmedia Networks: Links, Paths and Peripheries

    Science.gov (United States)

    Ruppel, Marc Nathaniel

    2012-01-01

    'Visualizing Transmedia Networks: Links, Paths and Peripheries' examines the increasingly complex rhetorical intersections between narrative and media ("old" and "new") in the creation of transmedia fictions, loosely defined as multisensory and multimodal stories told extensively across a diverse media set. In order…

  1. On Link Invariants and Topological String Amplitudes

    CERN Document Server

    Ramadevi, P; Sarkar, Tapobrata

    2001-01-01

    We explicitly show that the new polynomial invariants for knots, upto nine crossings, agree with the Ooguri-Vafa conjecture relating Chern-Simons gauge theory to topological string theory on the resolution of the conifold. From the multi-component link invariants in SU(N) Chern-Simons theory, we suggest a form for the new polynomial invariants.

  2. Linking Locations: Storytelling with Pervasive Technology

    OpenAIRE

    Jewell, Michael O.; Hooper, Clare J.

    2011-01-01

    With online location-aware smart phones in more and more pockets, storytelling is moving to the streets. Simultane- ously, an increasing abundance of Linked Data is being made available, complete with geographical information. In this paper, we review the state of the art and suggest approaches to, and issues with, a storytelling system that combines these two technologies.

  3. A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis.

    Science.gov (United States)

    Stark, Romana; Guebre-Egziabher, Fitsum; Zhao, Xiaojian; Feriod, Colleen; Dong, Jianying; Alves, Tiago C; Ioja, Simona; Pongratz, Rebecca L; Bhanot, Sanjay; Roden, Michael; Cline, Gary W; Shulman, Gerald I; Kibbey, Richard G

    2014-03-14

    Synthesis of phosphoenolpyruvate (PEP) from oxaloacetate is an absolute requirement for gluconeogenesis from mitochondrial substrates. Generally, this reaction has solely been attributed to the cytosolic isoform of PEPCK (PEPCK-C), although loss of the mitochondrial isoform (PEPCK-M) has never been assessed. Despite catalyzing the same reaction, to date the only significant role reported in mammals for the mitochondrial isoform is as a glucose sensor necessary for insulin secretion. We hypothesized that this nutrient-sensing mitochondrial GTP-dependent pathway contributes importantly to gluconeogenesis. PEPCK-M was acutely silenced in gluconeogenic tissues of rats using antisense oligonucleotides both in vivo and in isolated hepatocytes. Silencing PEPCK-M lowers plasma glucose, insulin, and triglycerides, reduces white adipose, and depletes hepatic glycogen, but raises lactate. There is a switch of gluconeogenic substrate preference to glycerol that quantitatively accounts for a third of glucose production. In contrast to the severe mitochondrial deficiency characteristic of PEPCK-C knock-out livers, hepatocytes from PEPCK-M-deficient livers maintained normal oxidative function. Consistent with its predicted role, gluconeogenesis rates from hepatocytes lacking PEPCK-M are severely reduced for lactate, alanine, and glutamine, but not for pyruvate and glycerol. Thus, PEPCK-M has a direct role in fasted and fed glucose homeostasis, and this mitochondrial GTP-dependent pathway should be reconsidered for its involvement in both normal and diabetic metabolism. PMID:24497630

  4. On the classification of links up to finite type

    DEFF Research Database (Denmark)

    Habegger, Nathan; Meilhan, Jean-Baptiste

    We use an action, of 2l-component string links on l-component string links, defined by the first author and Xiao-Song Lin, to lift the indeterminacy of finite type link invariants. The set of links up to this new indeterminacy is in bijection with the orbit space of the restriction of this action...

  5. The cross linking of EPDM and NBR rubber

    Directory of Open Access Journals (Sweden)

    Samardžija-Jovanović Suzana

    2005-01-01

    Full Text Available In the process of macromolecule cross linking, the choice of type and quantity of the components and the experimental conditions are important to obtain the new cross linked materials with better mechanical and chemical characteristics. The cross linking method depends on the rubber type and structure. Intermolecular cross linking results in the formation elastomer network. The basis of the cross linking process, between ethylene propylene diene rubber (EPDM and acrylonitrile butadiene rubber (NBR, is a chemical reaction. Fillers and other additives are present in different mass ratios in the material. The exploitation properties of the cross linked materials depend on the quantity of additive in the cross linked systems.

  6. Link failure detection in a parallel computer

    Science.gov (United States)

    Archer, Charles J.; Blocksome, Michael A.; Megerian, Mark G.; Smith, Brian E.

    2010-11-09

    Methods, apparatus, and products are disclosed for link failure detection in a parallel computer including compute nodes connected in a rectangular mesh network, each pair of adjacent compute nodes in the rectangular mesh network connected together using a pair of links, that includes: assigning each compute node to either a first group or a second group such that adjacent compute nodes in the rectangular mesh network are assigned to different groups; sending, by each of the compute nodes assigned to the first group, a first test message to each adjacent compute node assigned to the second group; determining, by each of the compute nodes assigned to the second group, whether the first test message was received from each adjacent compute node assigned to the first group; and notifying a user, by each of the compute nodes assigned to the second group, whether the first test message was received.

  7. Classification of Framed Links in 3-Manifolds

    Indian Academy of Sciences (India)

    Matija Cencelj; Dušan Repovš; Mikhail B Skopenkov

    2007-08-01

    We present a short and complete proof of the following Pontryagin theorem, whose original proof was complicated and has never been published in detail. Let be a connected oriented closed smooth 3-manifold, $L_1(M)$ be the set of framed links in up to a framed cobordism, and $\\deg: L_1(M)→ H_1(M;\\mathbb{Z})$ be the map taking a framed link to its homology class. Then for each $\\in H_1(M;\\mathbb{Z})$ there is a one-to-one correspondence between the set $\\deg^{-1}$ and the group $\\mathbb{Z}_{2d()}$, where () is the divisibility of the projection of to the free part of $H_1(M;\\mathbb{Z})$.

  8. Computational intelligence, medicine and biology selected links

    CERN Document Server

    Zaitseva, Elena

    2015-01-01

    This book contains an interesting and state-of the art collection of chapters presenting several examples of attempts to developing modern tools utilizing computational intelligence in different real life problems encountered by humans. Reasoning, prediction, modeling, optimization, decision making, etc. need modern, soft and intelligent algorithms, methods and methodologies to solve, in the efficient ways, problems appearing in human activity. The contents of the book is divided into two parts. Part I, consisting of four chapters, is devoted to selected links of computational intelligence, medicine, health care and biomechanics. Several problems are considered: estimation of healthcare system reliability, classification of ultrasound thyroid images, application of fuzzy logic to measure weight status and central fatness, and deriving kinematics directly from video records. Part II, also consisting of four chapters, is devoted to selected links of computational intelligence and biology. The common denominato...

  9. Regulatory mechanisms link phenotypic plasticity to evolvability.

    Science.gov (United States)

    van Gestel, Jordi; Weissing, Franz J

    2016-01-01

    Organisms have a remarkable capacity to respond to environmental change. They can either respond directly, by means of phenotypic plasticity, or they can slowly adapt through evolution. Yet, how phenotypic plasticity links to evolutionary adaptability is largely unknown. Current studies of plasticity tend to adopt a phenomenological reaction norm (RN) approach, which neglects the mechanisms underlying plasticity. Focusing on a concrete question - the optimal timing of bacterial sporulation - we here also consider a mechanistic approach, the evolution of a gene regulatory network (GRN) underlying plasticity. Using individual-based simulations, we compare the RN and GRN approach and find a number of striking differences. Most importantly, the GRN model results in a much higher diversity of responsive strategies than the RN model. We show that each of the evolved strategies is pre-adapted to a unique set of unseen environmental conditions. The regulatory mechanisms that control plasticity therefore critically link phenotypic plasticity to the adaptive potential of biological populations. PMID:27087393

  10. Teleoperation over low bandwidth communication links

    International Nuclear Information System (INIS)

    Teleoperation is well established for many areas of hazardous environment working. Where such environments are well structured and contained, such as within a working plant, communications bandwidths need not be a constraining factor. However where the worksite is remote, large, poorly structured or damaged communications rapidly become a critical factor in the efficient deployment and use of teleoperation equipment. The paper justifies and describes means which we are exploring to reduce the required communications bandwidth for teleoperation whist retaining full functionality. Techniques involved include incorporation of local intelligence at the worksite, with bandwidth devoted to high-level up-link control signals and down-link feedback, and the use of highly compressed video feeding 'virtual reality type' HMDs to provide maximum system transparency for the operator. The work is drawing on previous experience with an 'anthropomorphic robot heat' for telepresence work, and proprietary algorithms capable of compressing full colour video to standard telephone modem data rates. (Author)

  11. Quantum and classical optics–emerging links

    Science.gov (United States)

    Eberly, J. H.; Qian, Xiao-Feng; Qasimi, Asma Al; Ali, Hazrat; Alonso, M. A.; Gutiérrez-Cuevas, R.; Little, Bethany J.; Howell, John C.; Malhotra, Tanya; Vamivakas, A. N.

    2016-06-01

    Quantum optics and classical optics are linked in ways that are becoming apparent as a result of numerous recent detailed examinations of the relationships that elementary notions of optics have with each other. These elementary notions include interference, polarization, coherence, complementarity and entanglement. All of them are present in both quantum and classical optics. They have historic origins, and at least partly for this reason not all of them have quantitative definitions that are universally accepted. This makes further investigation into their engagement in optics very desirable. We pay particular attention to effects that arise from the mere co-existence of separately identifiable and readily available vector spaces. Exploitation of these vector-space relationships are shown to have unfamiliar theoretical implications and new options for observation. It is our goal to bring emerging quantum–classical links into wider view and to indicate directions in which forthcoming and future work will promote discussion and lead to unified understanding.

  12. Gulf producers and Asian markets: the links

    International Nuclear Information System (INIS)

    The paper discusses the growing links between Asia and the Middle East and focuses particularly on Japan's role. The recent problems in the Asian economy has not been helpful, but with recovery on the way it is expected that the link will resume steady growth. The paper leans heavily on the APEC (Asia Pacific Economic Cooperation) meeting hosted by the Japanese government in Okinawa in October 1998. The subjects discussed at the meeting were economic slowdown in Asia, energy infrastructure, energy security and environment. Some individual topics focused on are (i) energy supply and demand, (ii) oil imports (who buys from whom), (iii) the Japanese oil industry, (iv) increasing competition in the crude oil market, (v) natural gas and (vi) coal

  13. The RHIC real time data link system

    International Nuclear Information System (INIS)

    The RHIC Real Time Data Link (RTDL) System distributes to all locations around the RHIC ring machine parameters of general interest to accelerator systems and users. The system, along with supporting host interface, is centrally located. The RTDL System is comprised of two module types: the Encoder Module (V105) and the Input Module (V106). There is only one V105 module, but many (up to 128) Input Modules. Multiple buffered outputs are provided for use locally or for retransmission to other RHIC equipment locations. Machine parameters are generated from the V115 Waveform Generator Module (WFG) or from machine hardware and coupled directly through a fiber optic serial link to one of the V106 input channels

  14. Discovering Resume Information using linked data

    Directory of Open Access Journals (Sweden)

    Ujjal Marjit

    2012-05-01

    Full Text Available In spite of having different web applications to create and collect resumes, these web applications suffer mainly from a common standard data model, data sharing, and data reusing. Though, different web applications provide same quality of resume information, but internally there are many differences in terms of data structure and storage which makes computer difficult to process and analyse the information from different sources. The concept of Linked Data has enabled the web to share data among different data sources and to discover any kind of information while resolving the issues like heterogeneity, interoperability, and data reusing between different data sources and allowing machine process-able data on the web. In this paper we present Linked Data approach to discover resume information enabling the task aggregation, sharing and reusing the information among different resume information providers and organizations. We also demonstrate experimental results on semantically rich resume information.

  15. Link Graph Analysis for Adult Images Classification

    CERN Document Server

    Kharitonov, Evgeny; Muchnik, Ilya; Romanenko, Fedor; Belyaev, Dmitry; Kotlyarov, Dmitry

    2010-01-01

    In order to protect an image search engine's users from undesirable results adult images' classifier should be built. The information about links from websites to images is employed to create such a classifier. These links are represented as a bipartite website-image graph. Each vertex is equipped with scores of adultness and decentness. The scores for image vertexes are initialized with zero, those for website vertexes are initialized according to a text-based website classifier. An iterative algorithm that propagates scores within a website-image graph is described. The scores obtained are used to classify images by choosing an appropriate threshold. The experiments on Internet-scale data have shown that the algorithm under consideration increases classification recall by 17% in comparison with a simple algorithm which classifies an image as adult if it is connected with at least one adult site (at the same precision level).

  16. Depression And The Link With Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Arup Kumar Dhar

    2016-03-01

    Full Text Available This review provides an outline of the association between major depressive disorder (MDD and coronary heart disease (CHD. Much is known about the two individual clinical conditions; however it is not until recently, that biological mechanisms have been uncovered that link both MDD and CHD. The activation of stress pathways have been implicated as a neurochemical mechanism that links MDD and CHD. Depression is known to be associated with poorer outcomes of CHD. Psychological factors such as major depression and stress are now known as risk factors for developing CHD which is as important and is independent of classic risk factors such as hypertension, diabetes mellitus and cigarette smoking. Both conditions have great socioeconomic importance given that depression and CHD are likely to be two of the three leading causes of global burden of disease. Better understanding of the common causal pathways will help us delineate more appropriate treatments.

  17. Percolation on networks with dependence links

    International Nuclear Information System (INIS)

    As a classical model of statistical physics, the percolation theory provides a powerful approach to analyze the network structure and dynamics. Recently, to model the relations among interacting agents beyond the connection of the networked system, the concept of dependence link is proposed to represent the dependence relationship of agents. These studies suggest that the percolation properties of these networks differ greatly from those of the ordinary networks. In particular, unlike the well known continuous transition on the ordinary networks, the percolation transitions on these networks are discontinuous. Moreover, these networks are more fragile for a broader degree distribution, which is opposite to the famous results for the ordinary networks. In this article, we give a summary of the theoretical approaches to study the percolation process on networks with inter- and inner-dependence links, and review the recent advances in this field, focusing on the topology and robustness of such networks. (topical review - statistical physics and complex systems)

  18. Improving TCP Performance over Wireless Links Using Link-Layer Retransmission and Explicit Loss Notification

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In order to support the mobility of computers during communication, the transport control protocol (TCP) con-nections between fixed host and mobile host often traverse wired and wireless networks, and the recovery of the losses dueto wireless transmission error is much different from congestion control. This paper analyzes the interaction between TCPand link layer retransmission scheme when the correlated packet are losses handled, indicates that a higher value of themaximum number of successive link layer timeout retransmissions has an adverse effect on TCP ability to perform conges-tion control rapidly. To achieve a better TCP performance, the paper proposes a strategy combining link-layer selective-re-ject automatic repeat request (ARQ) with explicit loss notification mechanism, which can respond to congestion quicklywhile keeping wireless link more reliable, and make TCP react to the different packet losses more suitably.

  19. Blind links, a big challenge in the linked data idea: Analysis of Persian Subject Headings

    Directory of Open Access Journals (Sweden)

    Atefeh Sharif

    2014-12-01

    Full Text Available In this survey, Linked data concept as exposing, sharing, and connecting pieces of data, information, and knowledge on the Semantic Web and some potential problems in converting Persian subject headings (PSHs Records into linked data were discussed. A data set (11233 records of PSHs was searched in three information retrieval systems including National Library of Iran (NLI online catalog, Library of Congress (LC online catalog and NOSA books. Correct links between Persian and English subject headings in the 9519 common records of two catalogs were recorded. The results indicate that the links between Persian and English subjects in 20% of records were failed. The maximum error was associated with the anonymous databases (6/7 % in NLI online catalog. It is recommended to preprocess the PSHs records before any conversion projects. It seems that, during the preprocessing, the potential errors could be identified and corrected.

  20. A New Approach to the Link Budget Concept for an OAM Communication Link

    CERN Document Server

    Cagliero, Andrea; Gaffoglio, Rossella; Sacco, Bruno

    2015-01-01

    Following on from the increasing interest for electromagnetic waves carrying Orbital Angular Momentum (OAM), different configurations of antenna systems able to generate such beams have been proposed. However, in our opinion, a traditional radiation pattern approach does not provide the right picture of an OAM-based communication link. For this reason we propose a new general concept, the "OAM-link pattern", which takes into account the peculiar phase structure characterizing these waves. Focusing on OAM transmissions between antenna arrays, we introduce a formula for the link budget evaluation which describes the whole communication link and directly leads to a "classically shaped" main lobe pattern for a proper rephased reception in the case of uniform circular arrays.

  1. Alpha thalassaemia-mental retardation, X linked

    OpenAIRE

    Gibbons Richard

    2006-01-01

    Abstract X-linked alpha thalassaemia mental retardation (ATR-X) syndrome in males is associated with profound developmental delay, facial dysmorphism, genital abnormalities and alpha thalassaemia. Female carriers are usually physically and intellectually normal. So far, 168 patients have been reported. Language is usually very limited. Seizures occur in about one third of the cases. While many patients are affectionate with their caregivers, some exhibit autistic-like behaviour. Patients pres...

  2. Link between chips and cutting moments evolution

    CERN Document Server

    Cahuc, Olivier; Gérard, Alain; 10.4028/WWW.scientific.net/AMR.423.89

    2012-01-01

    The better understanding of the material cutting process has been shown with the benefit of the forces and moments measurement since some years ago. In paper, simultaneous six mechanical components and chip orientation measurements were realized during turning tests. During these tests, the influence of the depth of cut or feed rate has been observed and a link between the chip orientation and the moment vector orientation or the central axis characteristics has been shown.

  3. Equity-Linked Pension Schemes with Guarantees

    OpenAIRE

    J. Aase Nielsen; Klaus Sandmann; Erik Schlogl

    2010-01-01

    This paper analyses the relationship between the level of a return guarantee in an equity-linked pension scheme and the proportion of an investor's contribution needed to finance this guarantee. Three types of schemes are considered: investment guarantee, contribution guarantee and participation surplus. The evaluation of each scheme involves pricing an Asian option, for which relatively tight upper and lower bounds can be calculated in a numerically efficient manner. We find a negative (and ...

  4. Global sea level linked to global temperature

    OpenAIRE

    Vermeer, M.; Rahmstorf, S.

    2009-01-01

    We propose a simple relationship linking global sea-level variations on time scales of decades to centuries to global mean temperature. This relationship is tested on synthetic data from a global climate model for the past millennium and the next century. When applied to observed data of sea level and temperature for 1880–2000, and taking into account known anthropogenic hydrologic contributions to sea level, the correlation is >0.99, explaining 98% of the variance. For future global temperat...

  5. Hypercubic smeared links for dynamical fermions

    Energy Technology Data Exchange (ETDEWEB)

    Hasenfratz, A.; Hoffmann, R. [Colorado Univ., Boulder, CO (United States). Dept. of Physics; Schaefer, S. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC

    2007-02-15

    We investigate a variant of hypercubic gauge link smearing where the SU(3) projection is replaced with a normalization to the corresponding unitary group. This smearing is differentiable and thus suitable for use in dynamical fermion simulations using molecular dynamics type algorithms. We show that this smearing is as efficient as projected hypercubic smearing in removing ultraviolet noise from the gauge fields. We test the normalized hypercubic smearing in dynamical improved (clover) Wilson and valence overlap simulations. (orig.)

  6. Optical Link of the Atlas Pixel Detector

    OpenAIRE

    Gan, K. K.

    2007-01-01

    The on-detector optical link of the ATLAS pixel detector contains radiation-hard receiver chips to decode bi-phase marked signals received on PIN arrays and data transmitter chips to drive VCSEL arrays. The components are mounted on hybrid boards (opto-boards). We present results from the irradiation studies with 24 GeV protons up to 32 Mrad (1.2 x 10^15 p/cm^2) and the experience from the production.

  7. Linking numbers, spin, and statistics of solitons

    Science.gov (United States)

    Wilczek, F.; Zee, A.

    1983-01-01

    The spin and statistics of solitons in the (2 + 1)- and (3 + 1)-dimensional nonlinear sigma models is considered. For the (2 + 1)-dimensional case, there is the possibility of fractional spin and exotic statistics; for 3 + 1 dimensions, the usual spin-statistics relation is demonstrated. The linking-number interpretation of the Hopf invariant and the use of suspension considerably simplify the analysis.

  8. Improved estimation in cumulative link models

    OpenAIRE

    Kosmidis, I.

    2014-01-01

    For the estimation of cumulative link models for ordinal data, the bias-reducing adjusted score equations in \\citet{firth:93} are obtained, whose solution ensures an estimator with smaller asymptotic bias than the maximum likelihood estimator. Their form suggests a parameter-dependent adjustment of the multinomial counts, which, in turn suggests the solution of the adjusted score equations through iterated maximum likelihood fits on adjusted counts, greatly facilitating implementation. Like t...

  9. Sexuality and occupational therapy: Exploring the link

    OpenAIRE

    Simó i Algado, Salvador; Sakellariou, Dikaios

    2006-01-01

    Holism is perceived to be one of the major tenets of occupational therapy. This article discusses the relevance of sexuality to holistic health care and contributes to the continuing discussion regarding the legitimacy of sexuality as an area of concern for occupational therapists. Sexuality is an important part of the human experience and is linked closely with spirituality. However, it is often neglected by occupational therapists. The article explores the occupational nat...

  10. Savings and prize-linked savings accounts

    OpenAIRE

    Atalay, Kadir; Bakhtiar, Fayzan; Cheung, Stephen L.; Slonim, Robert

    2012-01-01

    Many households have insufficient savings to handle moderate and routine consumption shocks. Many of these financially fragile households also have the highest lottery expenditures as a proportion of income. This combination suggests that Prize-Linked Savings (PLS) accounts, that combine principal-security with lottery-type jackpots, can increase savings among these at-risk households. Results from an online experiment show that the introduction of PLS accounts increase total savings and redu...

  11. Link between vitamin D and airway remodeling

    OpenAIRE

    Berraies A; Hamzaoui K; Hamzaoui A

    2014-01-01

    Anissa Berraies, Kamel Hamzaoui, Agnes HamzaouiPediatric Respiratory Diseases Department, Abderrahmen Mami Hospital, Ariana, and Research Unit 12SP15 Tunis El Manar University, Tunis, TunisiaAbstract: In the last decade, many epidemiologic studies have investigated the link between vitamin D deficiency and asthma. Most studies have shown that vitamin D deficiency increases the risk of asthma and allergies. Low levels of vitamin D have been associated with asthma severity and loss of control, ...

  12. Cross-linking Chemistry of Squid Beak*

    OpenAIRE

    Miserez, Ali; Rubin, Daniel; Waite, J. Herbert

    2010-01-01

    In stark contrast to most aggressive predators, Dosidicus gigas (jumbo squids) do not use minerals in their powerful mouthparts known as beaks. Their beaks instead consist of a highly sclerotized chitinous composite with incremental hydration from the tip to the base. We previously reported l-3,4-dihydroxyphenylalanine (dopa)-histidine (dopa-His) as an important covalent cross-link providing mechanical strengthening to the beak material. Here, we present a more complete characterization of th...

  13. Achievable qualitative parameters of optical wireless links

    Czech Academy of Sciences Publication Activity Database

    Kolka, Z.; Wilfert, O.; Fišer, Ondřej

    2007-01-01

    Roč. 9, č. 8 (2007), s. 2419-2423. ISSN 1454-4164 R&D Projects: GA ČR(CZ) GA102/05/0571 Institutional research plan: CEZ:AV0Z30420517 Keywords : Free-space optical link * Transmission of atmosphere * Optical communication Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 0.827, year: 2007 http://inoe.inoe.ro/joam/index.php?option=magazine&op=view&idu=838&catid=16

  14. Compressive Link Acquisition in Multiuser Communications

    OpenAIRE

    Li, Xiao; Rueetschi, Andrea; Scaglione, Anna; Eldar, Yonina C.

    2012-01-01

    An important receiver operation is to detect the presence specific preamble signals with unknown delays in the presence of scattering, Doppler effects and carrier offsets. This task, referred to as "link acquisition", is typically a sequential search over the transmitted signal space. Recently, many authors have suggested applying sparse recovery algorithms in the context of similar estimation or detection problems. These works typically focus on the benefits of sparse recovery, but not gener...

  15. Tracking Federated Queries in the Linked Data

    OpenAIRE

    Nassopoulos, Georges; Serrano-Alvarado, Patricia; Molli, Pascal; Desmontils, Emmanuel

    2015-01-01

    Federated query engines allow data consumers to execute queries over the federation of Linked Data (LD). However, as feder-ated queries are decomposed into potentially thousands of subqueries distributed among SPARQL endpoints, data providers do not know fed-erated queries, they only know subqueries they process. Consequently, unlike warehousing approaches, LD data providers have no access to secondary data. In this paper, we propose FETA (FEderated query TrAcking), a query tracking algorithm...

  16. Link homology and equivariant gauge theory

    OpenAIRE

    Poudel, Prayat; Saveliev, Nikolai

    2015-01-01

    The singular instanton Floer homology was defined by Kronheimer and Mrowka in connection with their proof that the Khovanov homology is an unknot detector. We study this theory for knots and two-component links using equivariant gauge theory on their double branched covers. We show that the special generator in the singular instanton Floer homology of a knot is graded by the knot signature mod 4, thereby providing a purely topological way of fixing the absolute grading in the theory. Our appr...

  17. Personalized Federated Search at LinkedIn

    OpenAIRE

    Arya, Dhruv; Ha-Thuc, Viet; Sinha, Shakti

    2016-01-01

    LinkedIn has grown to become a platform hosting diverse sources of information ranging from member profiles, jobs, professional groups, slideshows etc. Given the existence of multiple sources, when a member issues a query like "software engineer", the member could look for software engineer profiles, jobs or professional groups. To tackle this problem, we exploit a data-driven approach that extracts searcher intents from their profile data and recent activities at a large scale. The intents s...

  18. Long haul underwater fiber optic link

    OpenAIRE

    Frank A. Denap

    1988-01-01

    Approved for public release; distribution is unlimited This thesis presents the design test and evaluation of a fiber optic remote monitoring system. Practical aspects of loss measurement, link analysis, receiver design, and controller implementation are examined. The fundamental operation of the system relies on conversion of the voltage data to be a variable frequency TTL pulse train. The pulse train modulates a 1300 nm laser, which transmits the telemetry data via single mode fiber to t...

  19. Linking Notch signaling to ischemic stroke

    OpenAIRE

    Arboleda-Velasquez, Joseph F.; Zhou, Zhipeng; Shin, Hwa Kyoung; Louvi, Angeliki; Kim, Hyung-Hwan; Savitz, Sean I.; Liao, James K.; Salomone, Salvatore; Ayata, Cenk; Moskowitz, Michael A.; Artavanis-Tsakonas, Spyros

    2008-01-01

    Vascular smooth muscle cells (SMCs) have been implicated in the pathophysiology of stroke, the third most common cause of death and the leading cause of long-term neurological disability in the world. However, there is little insight into the underlying cellular pathways that link SMC function to brain ischemia susceptibility. Using a hitherto uncharacterized knockout mouse model of Notch 3, a Notch signaling receptor paralogue highly expressed in vascular SMCs, we uncover a striking suscepti...

  20. Linking tourism, retirement migration and social capital

    OpenAIRE

    Casado Díaz, María Ángeles; Casado Díaz, Ana Belén; Casado Díaz, José Manuel

    2014-01-01

    A general trend in the study of international retirement migration has been the increased attention paid to the social contacts and network connections of the migrants in both the destination and the origin areas. These studies have examined the extent to which migrants build social relationships with their neighbours and the host society while also maintaining social links with their countries of origin, addressing the central role that leisure travel plays in sustaining increasingly dispers...

  1. On identification problems requiring linked autosomal markers.

    Science.gov (United States)

    Egeland, Thore; Sheehan, Nuala

    2008-06-01

    This paper considers identification problems based on DNA marker data. The topics we discuss are general, but we will exemplify them in a simple context. There is DNA available from two persons. There is uncertainty about the relationship between the two individuals and a number of hypotheses describing the possible relationship is available. The task is to determine the most likely pedigree. This problem is fairly standard. However, there are some problems that cannot be solved using DNA from independently segregating loci. For example, the likelihoods for (i) grandparent-grandchild, (ii) uncle-niece and (iii) half-sibs coincide for such DNA data and so these relations cannot be distinguished on the basis of markers normally used for forensic identification problems: the likelihood ratio comparing any pair of hypotheses will be unity. Sometimes, but not in the examples we consider, other sources of DNA like mtDNA or sex chromosomes can help to distinguish between such equally likely possibilities. Prior information can likewise be of use. For instance, age information can exclude alternative (i) above and also indicate that alternative (iii) is apriori more likely than alternative (ii). More generally, the above problems can be solved using linked autosomal markers. To study the problem in detail and understand how linkage works in this regard, we derive an explicit formula for a pair of linked markers. The formula extends to independent pairs of linked markers. While this approach adds to the understanding of the problem, more markers are required to obtain satisfactory results and then the Lander-Green algorithm is needed. Simulation experiments are presented based on a range of scenarios and we conclude that useful results can be obtained using available freeware (MERLIN and R). The main message of this paper is that linked autosomal markers deserve greater attention in forensic genetics and that the required laboratory and statistical analyses can be performed

  2. Linking global turnover of species and environments

    OpenAIRE

    Buckley, Lauren B.; Jetz, Walter

    2008-01-01

    Patterns of species turnover are central to the geography of biodiversity and resulting challenges for conservation, but at broad scales remain relatively little understood. Here, we take a first spatially-explicitly and global perspective to link the spatial turnover of species and environments. We compare how major groups of vertebrate ectotherms (amphibians) and endotherms (birds) respond to spatial environmental gradients. We find that high levels of species turnover occur regardless of e...

  3. Evaluation Of Radio Links And Networks

    OpenAIRE

    Jean-Paul M. G. Linnartz; Diesta, Rolando F.

    1996-01-01

    This study evaluates the performance of radio links and networks to support communication with Automatic Vehicle Control Systems (AVCS). It addresses both vehicle-to-vehicle communication and roadside-to-vehicle communication. The report contributes to the modelling of short range vehicle-to-vehicle channels, not only in terms of documenting measured results and channel parameters, but also in extending existing models to cover antenna mobility at both receiver and transmitter simultaneously....

  4. Detection Implicit Links and G-betweenness

    OpenAIRE

    Zhenirovskyy, M. I.; Lande, D. V.; Snarskii, A. A.

    2010-01-01

    A concept of implicit links for Complex Networks has been defined and a new value - cohesion factor, which allows to evaluate numerically the presence of such connection between any two nodes, has been introduced. We introduce a generalization of such characteristics as the betweenness, which allows to rank network nodes in more details. The effectiveness of the proposed concepts is shown by the numerical examples.

  5. Towards Performing Arts Information As Linked Data?

    OpenAIRE

    Le Boeuf, Patrick

    2012-01-01

    International audience Semantic Web technologies and Linked Data are of crucial importance for cultural heritage institutions, as they will allow them to share data, both among them and with any kind of other agents who will be thus enabled to reuse that valuable knowledge in a variety of ways. They rely, among other things, on ontologies that provide unified representations of the (often heterogeneous) information produced by such institutions. The FRBROO model (Functional Requirements fo...

  6. Linking snowpack microphysics and albedo evolution

    OpenAIRE

    Mark G. Flanner; Zender, Charles S

    2006-01-01

     Snow aging causes reflectance to vary significantly on timescales of days. This variability influences the strength of snow albedo feedback and can affect the timing of snowmelt. However, climate models have yet to incorporate important controls on snow aging and albedo evolution. We develop a physically based model that predicts evolution of dry, pure snow specific surface area, and apply aspherical ice particle theory to link these results with albedo evolution. This is the first theoretic...

  7. Language-integrated provenance in Links

    OpenAIRE

    Cheney, James; Fehrenbach, Stefan

    2015-01-01

    Today’s programming languages provide no support for data provenance. In a world that increasingly relies on data, we need provenance to judge the reliability of data and therefore should aim for making it easily accessible to programmers. We report our work in progress on an extension to the Links programming language that builds on its support for language-integrated query to support where-provenance queries through query rewriting and a type system extension that distinguishes provenance m...

  8. Weak thermal links for thermal cycling experiments

    International Nuclear Information System (INIS)

    Two types of thermal links - wire coupling and Kapitza coupling - for thermal cycling (TC) experiments are studied. Quantitative models describing static and dynamic behaviour of the sample temperature are developed and experimentally tested. There is a wide range of applications for both couplings, the most severe limitations are imposed by nuclear heat capacities. Kapitza coupling is restricted to thin foil samples, but potentially offers the fastest response. (orig.)

  9. Improving Frequent Link Failure Detection in VANET

    OpenAIRE

    M.Sakthi ganesh; Dr. P. Venkata Krishna

    2013-01-01

    VANET technology integrates wireless cellular and ad hoc for seamless connectivity between vehicles. Vehicle ad-hoc networks (VANETs) are systems that allow vehicles to communicate with each other. Wireless-vice can send information to nearby vehicles, and messages can be sent from one vehicle to another, so that the informationcan be spread throughout the city. In the network, there is a link failure very common due to the high mobility of nodes in the network region available. So what makes...

  10. Multiple Pathways Linking Racism to Health Outcomes

    OpenAIRE

    Harrell, Camara Jules P.; Burford, Tanisha I.; Cage, Brandi N.; Nelson, Travette McNair; Shearon, Sheronda; Thompson, Adrian; Green, Steven

    2011-01-01

    This commentary discusses advances in the conceptual understanding of racism and selected research findings in the social neurosciences. The traditional stress and coping model holds that racism constitutes a source of aversive experiences that, when perceived by the individual, eventually lead to poor health outcomes. Current evidence points to additional psychophysiological pathways linking facets of racist environments with physiological reactions that contribute to disease. The alternativ...

  11. Thermal Analyse sof Cross-Linked Polyethylene

    Directory of Open Access Journals (Sweden)

    Radek Polansky

    2007-01-01

    Full Text Available The paper summarizes results obtained during the structural analyses measurements (Differential Scanning Calorimetry DSC, Thermogravimetry TG, Thermomechanical analysis TMA and Fourier transform infrared spectroscopy FT-IR. The samples of cross-linked polyethylene cable insulation were tested via these analyses. The DSC and TG were carried out using simultaneous thermal analyzer TA Instruments SDT Q600 with connection of Fourier transform infrared spectrometer Nicolet 380. Thermomechanical analysis was carried out by TMA Q400EM TA Instruments apparatus.

  12. Leaf morphology shift linked to climate change

    OpenAIRE

    Guerin, Greg R.; Wen, Haixia; Lowe, Andrew J

    2012-01-01

    Climate change is driving adaptive shifts within species, but research on plants has been focused on phenology. Leaf morphology has demonstrated links with climate and varies within species along climate gradients. We predicted that, given within-species variation along a climate gradient, a morphological shift should have occurred over time due to climate change. We tested this prediction, taking advantage of latitudinal and altitudinal variations within the Adelaide Geosyncline region, Sout...

  13. Evidence on the complex link between

    OpenAIRE

    Moreno Serrano, Rosina; Artís Ortuño, Manuel; López-Bazo, Enrique; Suriñach Caralt, Jordi

    1997-01-01

    Most studies analysing the infrastructure impact on regional growth show a positive relationship between both variables. However, the public capital elasticity estimated in a Cobb-Douglas function, which is the most common specification in these works, is sometimes too big to be credible, so that the results have been partially desestimated. In the present paper, we give some new advances on the real link between public capital and productivity for the Spanish regions in the period 1964-1991....

  14. Characterization of Cross-Linked Lipase Aggregates

    DEFF Research Database (Denmark)

    Prabhavathi Devi, Bethala Lakshmi Anu; Guo, Zheng; Xu, Xuebing

    2009-01-01

    Commercially available microbial lipases from different sources were immobilized as cross-linked enzyme aggregates (CLEAs) using different precipitants and glutaraldehyde as cross-linkers. These CLEAs were assayed based on esterification between lauric acid and n-propanol in solvent-free systems....... change upon CLEA formation. This work presents a characterization of CLEAs based on an esterification activity assay, which is useful for exploring the synthetic application potential of CLEA technology with favorable perspectives....

  15. Empathy and autobiographical memory: are they linked?

    Science.gov (United States)

    Tani, Franca; Peterson, Carole; Smorti, Andrea

    2014-01-01

    Autobiographical memory and empathy have been linked with social interaction variables as well as gender in independent bodies of literature. However a scarcity of research exists on the direct link between autobiographical memory and empathy. Exploring this link, in particular for memory of friendships and empathy, was the authors' main aim. A total of 107 Italian undergraduates participated. A memory fluency task was used to assess accessibility of memories spanning their entire life (preschool through university) and an empathy scale (Italian version of the Interpersonal Reactivity Index) was employed to measure the participants' level and dimensions of empathy. For men, empathy scores were related to how many memories they could recall. Specifically, men with higher scores on the fantasy and empathic concern scales and those with lower scores on the personal distress scales recalled more memories of friends. However, affective quality of their memories was unrelated to empathy. In contrast, for women there was no relationship between number of memories and empathy, but the emotional tone of their memories was related to empathy: those with higher scores on the personal distress scale had proportionately fewer affectively positive memories. Results are discussed in terms of gender differences in both empathy and parental socialization patterns. PMID:25175530

  16. Collagen cross-linking in thin corneas

    Directory of Open Access Journals (Sweden)

    Prema Padmanabhan

    2013-01-01

    Full Text Available Collagen cross-linking (CXL has become the standard of care for progressive keratoconus, after numerous clinical studies have established its efficacy and safety in suitably selected eyes. The standard protocol is applicable in eyes which have a minimum corneal thickness of 400 μm after epithelial debridement. This prerequisite was stipulated to protect the corneal endothelium and intraocular tissues from the deleterious effect of ultraviolet-A (UVA radiation. However, patients with keratoconus often present with corneal thickness of less than 400 μm and could have otherwise benefited from this procedure. A few modifications of the standard procedure have been suggested to benefit these patients without a compromise in safety. Transepithelial cross-linking, pachymetry-guided epithelial debridement before cross-linking, and the use of hypoosmolar riboflavin are some of the techniques that have been attempted. Although clinical data is limited at the present time, these techniques are worth considering in patients with thin corneas. Further studies are needed to scientifically establish their efficacy and safety.

  17. Percolation of networks with directed dependency links

    Science.gov (United States)

    Niu, Dunbiao; Yuan, Xin; Du, Minhui; Stanley, H. Eugene; Hu, Yanqing

    2016-04-01

    The self-consistent probabilistic approach has proven itself powerful in studying the percolation behavior of interdependent or multiplex networks without tracking the percolation process through each cascading step. In order to understand how directed dependency links impact criticality, we employ this approach to study the percolation properties of networks with both undirected connectivity links and directed dependency links. We find that when a random network with a given degree distribution undergoes a second-order phase transition, the critical point and the unstable regime surrounding the second-order phase transition regime are determined by the proportion of nodes that do not depend on any other nodes. Moreover, we also find that the triple point and the boundary between first- and second-order transitions are determined by the proportion of nodes that depend on no more than one node. This implies that it is maybe general for multiplex network systems, some important properties of phase transitions can be determined only by a few parameters. We illustrate our findings using Erdős-Rényi networks.

  18. Local Community Detection Using Link Similarity

    Institute of Scientific and Technical Information of China (English)

    Ying-Jun Wu; Han Huang; Zhi-Feng Hao; Feng Chen

    2012-01-01

    Exploring local community structure is an appealing problem that has drawn much recent attention in the area of social network analysis.As the complete information of network is often difficult to obtain,such as networks of web pages,research papers and Facebook users,people can only detect community structure from a certain source vertex with limited knowledge of the entire graph.The existing approaches do well in measuring the community quality,but they are largely dependent on source vertex and putting too strict policy in agglomerating new vertices.Moreover,they have predefined parameters which are difficult to obtain.This paper proposes a method to find local community structure by analyzing link similarity between the community and the vertex.Inspired by the fact that elements in the same community are more likely to share common links,we explore community structure heuristically by giving priority to vertices which have a high link similarity with the community.A three-phase process is also used for the sake of improving quality of community structure.Experimental results prove that our method performs effectively not only in computer-generated graphs but also in real-world graphs.

  19. DOIs Should Not Link to Data

    Science.gov (United States)

    Hourcle, J. A.

    2013-12-01

    In August of 2011, the National Academy of Science's Board of Research Data and Information (BRDI) had a meeting on the topic of "Developing Data Attribution and Citation Practices and Standards". As part of that meeting were various breakout groups to discuss issues that still remained regarding technical, scientific, and socio-cultural issues, the roles and actors that needed to be involved, and how to get additional feedback from the community. The technical breakout group decided that the majority of the technical problems with citing data revolved around establishing the identity of what it was that we were attempting to cite. As such, our recommendations were to push some of the work back onto the data publishers to tell us how scientists should cite their data (to avoid different disciplines applying different rules), establish 'data landing pages' to describe, document and link to the data, and to provide those pages with persistent identifiers such as a DOI. We present here some of the reasons that were discussed about why not to link directly to data, including: * recalibration, reaccessioning and other data impermanence, * setting context and providing for links to documentation, and * allowing selection of different packaging formats

  20. Link lengths and their growth powers

    International Nuclear Information System (INIS)

    For a certain infinite family F of knots or links, we study the growth power ratios of their stick number, lattice stick number, minimum lattice length and minimum ropelength compared with their minimum crossing number c(K) for every K∈F. It is known that the stick number and lattice stick number grow between the (1/2) and linear power of the crossing number, and minimum lattice length and minimum ropelength grow with at least the (3/4) power of crossing number (which is called the four-thirds power law). Furthermore, the minimal lattice length and minimum ropelength grow at most as O (c(K)[ln(c(K))]5), but it is unknown whether any family exhibits superlinear growth. For any real number r between (1/2) and 1, we give an infinite family of non-splittable prime links in which the stick number and lattice stick number grow exactly as the rth power of crossing number. Furthermore for any real number r between (3/4) and 1, we give another infinite family of non-splittable prime links in which the minimum lattice length and minimum ropelength grow exactly as the rth power of crossing number. (paper)

  1. Positive tone cross-linked resists based on photoacid inhibition of cross linking

    Science.gov (United States)

    Lawson, Richard A.; Chun, Jun Sung; Neisser, Mark; Tolbert, Laren M.; Henderson, Clifford L.

    2014-03-01

    A resist imaging design that utilizes photoacid inhibition of cationic polymerization and cross-linking during a postexposure bake step has been studied. The key to the design approach is the use of two different polymerization catalysts/initiators: (1) a photoacid produced from a photoacid generator (PAG) upon exposure of the resist that can result in polymerization and cross-linking of the resist matrix and (2) a thermal cross-linking catalyst (TCC) designed to thermally catalyze epoxide-phenol cross-linking. The TCC can be chosen from a variety of compounds such as triphenylphosphine (TPP) or imidazole. When only one of these catalysts (e.g TPP or photoacid) is present in an epoxide and phenol containing resist matrix, it will individually catalyze cross-linking. When they are present together, they effectively quench one another and little to no cross-linking occurs. This approach can be used to switch the tone of a resist from negative (photoacid catalyzed) to positive (TCC catalyzed and photoacid inhibited). The effect of the ratio of TCC:PAG was examined and the optimal ratio for positive tone behavior was determined. Resist contrast can be modified by optimization of epoxide:phenol ratio in the formulation. Dual tone behavior with positive tone at low dose and negative tone at higher doses can be observed in certain formulation conditions. Initial EUV patterning shows poor results, but the source of the poor imaging is not yet understood.

  2. Challenges and Usage of Link Mining to Semantic Web

    Directory of Open Access Journals (Sweden)

    Zaved Akhtar

    2012-03-01

    Full Text Available - It is an emerging challenge for data mining is the problem of mining richly structures datasets, where the objects are linked in some way. Links among the objects may demonstrate certain patterns, which can be helpful for many data mining tasks and are usually hard to capture with traditional statistical models. Many datasets of interest today are best described as a linked collection of interrelated objects. These may represent homogeneous networks, in which there is a single-object type and link type (eg. people connected by friendship links, or the WWW, a collection of linked web pages or richer, heterogeneous networks, in which there may be multiple object and link types (and possibly other semantic information. Examples of heterogeneous networks include those in medical domains describing patients, diseases, treatments and contacts, or in bibliographic domains describing publications, authors, and venues. Link mining refers to data mining techniques that explicitly consider these links when building predictive or descriptive models of the linked data. Commonly addressed link mining tasks include object ranking, group detection, collective classification, link prediction and subgraph discovery. This is an exciting and rapidly expanding area. In this article we review some of the common emerging themes and discuss ongoing link mining challenges; open issues and suggest ideas that could be opportunities for solutions. The most conclusion of this article is that providing an idea to usage link mining techniques from link mining to help to construct the Semantic Web.

  3. Optimisation of the link volume for weakest link failure prediction in NBG-18 nuclear graphite

    International Nuclear Information System (INIS)

    This paper describes the process for approximating the optimal size of a link volume required for weakest link failure calculation in nuclear graphite, with NBG-18 used as an example. As part of the failure methodology, the link volume is defined in terms of two grouping criteria. The first criterion is a factor of the maximum grain size and the second criterion is a function of an equivalent stress limit. A methodology for approximating these grouping criteria is presented. The failure methodology employs finite element analysis (FEA) in order to predict the failure load, at 50% probability of failure. The average experimental failure load, as determined for 26 test geometries, is used to evaluate the accuracy of the weakest link failure calculations. The influence of the two grouping criteria on the failure load prediction is evaluated by defining an error in prediction across all test cases. Mathematical optimisation is used to find the minimum error across a range of test case failure predictions. This minimum error is shown to deliver the most accurate failure prediction across a whole range of components, although some test cases in the range predict conservative failure load. The mathematical optimisation objective function is penalised to account for non-conservative prediction of the failure load for any test case. The optimisation is repeated and a link volume found for conservative failure prediction. The failure prediction for each test case is evaluated, in detail, for the proposed link volumes. Based on the analysis, link design volumes for NBG-18 are recommended for either accurate or conservative failure prediction

  4. Optimisation of the link volume for weakest link failure prediction in NBG-18 nuclear graphite

    Energy Technology Data Exchange (ETDEWEB)

    Hindley, Michael P., E-mail: makke@mweb.co.za [Pebble Bed Modular Reactor (Pty) Ltd., PO Box 12271, Centurion 0046 (South Africa); Groenwold, Albert A.; Blaine, Deborah C.; Becker, Thorsten H. [Department of Mechanical and Mechatronic Engineering, Stellenbosch University, Private Bag X1, Matieland 7602 (South Africa)

    2014-07-01

    This paper describes the process for approximating the optimal size of a link volume required for weakest link failure calculation in nuclear graphite, with NBG-18 used as an example. As part of the failure methodology, the link volume is defined in terms of two grouping criteria. The first criterion is a factor of the maximum grain size and the second criterion is a function of an equivalent stress limit. A methodology for approximating these grouping criteria is presented. The failure methodology employs finite element analysis (FEA) in order to predict the failure load, at 50% probability of failure. The average experimental failure load, as determined for 26 test geometries, is used to evaluate the accuracy of the weakest link failure calculations. The influence of the two grouping criteria on the failure load prediction is evaluated by defining an error in prediction across all test cases. Mathematical optimisation is used to find the minimum error across a range of test case failure predictions. This minimum error is shown to deliver the most accurate failure prediction across a whole range of components, although some test cases in the range predict conservative failure load. The mathematical optimisation objective function is penalised to account for non-conservative prediction of the failure load for any test case. The optimisation is repeated and a link volume found for conservative failure prediction. The failure prediction for each test case is evaluated, in detail, for the proposed link volumes. Based on the analysis, link design volumes for NBG-18 are recommended for either accurate or conservative failure prediction.

  5. Musical Preferences are Linked to Cognitive Styles.

    Directory of Open Access Journals (Sweden)

    David M Greenberg

    Full Text Available Why do we like the music we do? Research has shown that musical preferences and personality are linked, yet little is known about other influences on preferences such as cognitive styles. To address this gap, we investigated how individual differences in musical preferences are explained by the empathizing-systemizing (E-S theory. Study 1 examined the links between empathy and musical preferences across four samples. By reporting their preferential reactions to musical stimuli, samples 1 and 2 (Ns = 2,178 and 891 indicated their preferences for music from 26 different genres, and samples 3 and 4 (Ns = 747 and 320 indicated their preferences for music from only a single genre (rock or jazz. Results across samples showed that empathy levels are linked to preferences even within genres and account for significant proportions of variance in preferences over and above personality traits for various music-preference dimensions. Study 2 (N = 353 replicated and extended these findings by investigating how musical preferences are differentiated by E-S cognitive styles (i.e., 'brain types'. Those who are type E (bias towards empathizing preferred music on the Mellow dimension (R&B/soul, adult contemporary, soft rock genres compared to type S (bias towards systemizing who preferred music on the Intense dimension (punk, heavy metal, and hard rock. Analyses of fine-grained psychological and sonic attributes in the music revealed that type E individuals preferred music that featured low arousal (gentle, warm, and sensual attributes, negative valence (depressing and sad, and emotional depth (poetic, relaxing, and thoughtful, while type S preferred music that featured high arousal (strong, tense, and thrilling, and aspects of positive valence (animated and cerebral depth (complexity. The application of these findings for clinicians, interventions, and those on the autism spectrum (largely type S or extreme type S are discussed.

  6. Linking microarray reporters with protein functions

    Directory of Open Access Journals (Sweden)

    Gaj Stan

    2007-09-01

    Full Text Available Abstract Background The analysis of microarray experiments requires accurate and up-to-date functional annotation of the microarray reporters to optimize the interpretation of the biological processes involved. Pathway visualization tools are used to connect gene expression data with existing biological pathways by using specific database identifiers that link reporters with elements in the pathways. Results This paper proposes a novel method that aims to improve microarray reporter annotation by BLASTing the original reporter sequences against a species-specific EMBL subset, that was derived from and crosslinked back to the highly curated UniProt database. The resulting alignments were filtered using high quality alignment criteria and further compared with the outcome of a more traditional approach, where reporter sequences were BLASTed against EnsEMBL followed by locating the corresponding protein (UniProt entry for the high quality hits. Combining the results of both methods resulted in successful annotation of > 58% of all reporter sequences with UniProt IDs on two commercial array platforms, increasing the amount of Incyte reporters that could be coupled to Gene Ontology terms from 32.7% to 58.3% and to a local GenMAPP pathway from 9.6% to 16.7%. For Agilent, 35.3% of the total reporters are now linked towards GO nodes and 7.1% on local pathways. Conclusion Our methods increased the annotation quality of microarray reporter sequences and allowed us to visualize more reporters using pathway visualization tools. Even in cases where the original reporter annotation showed the correct description the new identifiers often allowed improved pathway and Gene Ontology linking. These methods are freely available at http://www.bigcat.unimaas.nl/public/publications/Gaj_Annotation/.

  7. Optical links in handheld multimedia devices

    Science.gov (United States)

    van Geffen, S.; Duis, J.; Miller, R.

    2008-04-01

    Ever emerging applications in handheld multimedia devices such as mobile phones, laptop computers, portable video games and digital cameras requiring increased screen resolutions are driving higher aggregate bitrates between host processor and display(s) enabling services such as mobile video conferencing, video on demand and TV broadcasting. Larger displays and smaller phones require complex mechanical 3D hinge configurations striving to combine maximum functionality with compact building volumes. Conventional galvanic interconnections such as Micro-Coax and FPC carrying parallel digital data between host processor and display module may produce Electromagnetic Interference (EMI) and bandwidth limitations caused by small cable size and tight cable bends. To reduce the number of signals through a hinge, the mobile phone industry, organized in the MIPI (Mobile Industry Processor Interface) alliance, is currently defining an electrical interface transmitting serialized digital data at speeds >1Gbps. This interface allows for electrical or optical interconnects. Above 1Gbps optical links may offer a cost effective alternative because of their flexibility, increased bandwidth and immunity to EMI. This paper describes the development of optical links for handheld communication devices. A cable assembly based on a special Plastic Optical Fiber (POF) selected for its mechanical durability is terminated with a small form factor molded lens assembly which interfaces between an 850nm VCSEL transmitter and a receiving device on the printed circuit board of the display module. A statistical approach based on a Lean Design For Six Sigma (LDFSS) roadmap for new product development tries to find an optimum link definition which will be robust and low cost meeting the power consumption requirements appropriate for battery operated systems.

  8. Key agreement over a radio link

    OpenAIRE

    Cagalj, Mario; Hubaux, Jean-Pierre

    2004-01-01

    We present a simple, and yet powerful, technique for key establishment over a radio link in peer-to-peer networks. Our approach is based on the Diffie-Hellman key agreement protocol. This protocol is known to be vulnerable to the ``man-in-the-middle" attack if two users involved in the protocol share no authenticated information about each other (e.g., public keys) prior to the protocol execution. In this work, we show how the natural ability of users to authenticate each other by visual and ...

  9. Bidirectional ROF Links with Dynamic Capacity Allocation

    Directory of Open Access Journals (Sweden)

    Rakesh Kumar Chandan , Dharmendra Singh

    2013-10-01

    Full Text Available : Radio over fiber (ROF technology is an integration of wireless and fiber optic network. It plays vital role for broad band wireless communication. The well known advantages of optical as a transmission medium such as low loss, light weight, large bandwidth characteristics, small size and low cable cost make it the ideal and most flexible solution for efficiently transporting radio signals to remotely located antenna site in a wireless network. The joint venture of radio signal and optical fiber technology provides dynamic capacity allocation in radio over fiber links.

  10. Polybinary modulation for bandwidth limited optical links

    DEFF Research Database (Denmark)

    Vegas Olmos, Juan José; Jurado-Navas, Antonio

    2015-01-01

    Optical links using traditional modulation formats are reaching a plateau in terms of capacity, mainly due to bandwidth limitations in the devices employed at the transmitter and receivers. Advanced modulation formats, which boost the spectral efficiency, provide a smooth migration path towards...... form of partial response modulation, employs simple codification and filtering at the transmitter to drastically increase the spectral efficiency. At the receiver side, poly binary modulation requires low complexity direct detection and very little digital signal processing. This talk will review the...

  11. Design And Analysis Of Optical Communication Links

    Science.gov (United States)

    Lesh, J. R.; Marshall, W. K.; Katz, J.

    1989-01-01

    To convey to prospective designers intuitive understanding based on unique characteristics of optical communication systems, report presents method of design and analysis of outer-space optical communication link using pulse-position modulation (PPM) and in which received signal sufficiently weak to require detection by photomultiplier operating in photon-counting mode. Step 1 requires some knowledge or assumptions about parameters of transmitter and receiver. Step 2 determination of average number of background-noise photons detected during PPM timeslot. Step 3 average number, Ps of signal photons detected per signal pulse compared with average number, Pn of noise pulses detected per PPM timeslot.

  12. Link Label Prediction in Signed Citation Network

    KAUST Repository

    Akujuobi, Uchenna

    2016-04-12

    Link label prediction is the problem of predicting the missing labels or signs of all the unlabeled edges in a network. For signed networks, these labels can either be positive or negative. In recent years, different algorithms have been proposed such as using regression, trust propagation and matrix factorization. These approaches have tried to solve the problem of link label prediction by using ideas from social theories, where most of them predict a single missing label given that labels of other edges are known. However, in most real-world social graphs, the number of labeled edges is usually less than that of unlabeled edges. Therefore, predicting a single edge label at a time would require multiple runs and is more computationally demanding. In this thesis, we look at link label prediction problem on a signed citation network with missing edge labels. Our citation network consists of papers from three major machine learning and data mining conferences together with their references, and edges showing the relationship between them. An edge in our network is labeled either positive (dataset relevant) if the reference is based on the dataset used in the paper or negative otherwise. We present three approaches to predict the missing labels. The first approach converts the label prediction problem into a standard classification problem. We then, generate a set of features for each edge and then adopt Support Vector Machines in solving the classification problem. For the second approach, we formalize the graph such that the edges are represented as nodes with links showing similarities between them. We then adopt a label propagation method to propagate the labels on known nodes to those with unknown labels. In the third approach, we adopt a PageRank approach where we rank the nodes according to the number of incoming positive and negative edges, after which we set a threshold. Based on the ranks, we can infer an edge would be positive if it goes a node above the

  13. Sharp Connection: Linking Competitive Intelligence and Intranets

    OpenAIRE

    Hendriks, P.H.J.; Jacobs, W.H.

    2003-01-01

    Assessing the value of ICT to support Competitive Intelligence presumes an understanding of the relationship between the two. The chapter argues that starting from either the ICT or CI side to this relationship and linking to the other, as most studies do, cannot secure a fully adequate conception of ICT’s value to CI. Instead, the challenge is to find an appropriate foundation in the relationship itself and use it as a stepping stone for developing an understanding of both ICT and CI. The ch...

  14. Term Bases and Linguistic Linked Open Data

    DEFF Research Database (Denmark)

    for pursuing their work. The theme of this year’s TKE is ‘Term Bases and Linguistic Linked Open Data’. Mono- and multi-lingual term bases, which contain information about concepts (terms, definitions, examples of use, references, comments on equivalence etc.), have always made up valuable linguistic resources....... Today, some terminology and knowledge bases combine traditional term bases and terminological ontologies, where concepts are related by means of various types of concept relations, and are further described by means of characteristics....

  15. An optical communication link on the Shuttle

    Science.gov (United States)

    Grady, Jane L.

    A communication link for the transfer of data between the crew cabin and payload bay of the Shuttle is proposed. The configuration of the system, which is to transmit data optically through the Shuttle cabin window, is described. The effects of temperature cycling and cosmic radiation on optical fibers, the cable, connectors, and lenses, and of vibrations during a mission on the alignment of collimating lenses at the window are investigated. Consideration is given to determining the optimum design for the optical fiber and the optimum system operation wavelength for transmission through the aft Orbiter window and the payload environment.

  16. Links between nuclear medicine and radiopharmacy

    International Nuclear Information System (INIS)

    Radiopharmaceuticals are nowadays under the responsibility of the radio-pharmacist because of their medicinal product status. Radiopharmacy belongs to the hospital pharmacy department, nevertheless, interactions with nuclear medicine department are important: rooms are included or located near nuclear medicine departments in order to respect radiation protection rules, more over staff, a part of the material and some activities are shared between the two departments. Consequently, it seems essential to formalize links between the radiopharmacy and the nuclear medicine department, setting the goals to avoid conflicts and to ensure patients' security. Modalities chosen for this formalization will depend on the establishment's organization. (authors)

  17. France-United Kingdom rail link

    Energy Technology Data Exchange (ETDEWEB)

    Machefert-Tassin, Y.; Julien, L.

    1995-07-01

    To accomplish the France-England rail link, it was necessary to resolve power supply problems involving phase imbalance by a ``star`` arrangement with the addition of capacitors, capacitive and inductive loads. Since the tunnel has to accommodate a variety of locomotives with very stringent operating criteria, it was necessary to design train power systems involving a combination of existing systems. The asynchronous traction motor was chosen for its low weight and its potential for energy recovery for braking and for other trains. Each bogie has its own auxiliary converter. The control system uses a common live with an omnibus interface or ``bus line``. Communication is via optical fibres. (author). 6 figs.

  18. High Capacity Radio over Fiber Transmission Links

    DEFF Research Database (Denmark)

    Caballero Jambrina, Antonio

    achievement has satisfied the requirements on transmission robustness and high capacity of next generation hybrid optical fibre-wireless networks. One important contribution of this thesis is the novel concept of photonic downconversion with free-running pulsed laser source for phase modulated Radio-over-Fiber......, it was the highest bitrate reported of a wireless signal, with complex modulation format, detected using photonic means. I have developed an analytical model to support the experimental results and performed a linearity characterization to establish engineering design rules for this type of links...

  19. Cross-linking for microbial keratitis

    Directory of Open Access Journals (Sweden)

    Jayesh Vazirani

    2013-01-01

    Full Text Available The success of collagen cross-linking as a clinical modality to modify the clinical course in keratoconus seems to have fueled the search for alternative applications for this treatment. Current clinical data on its efficacy is limited and laboratory data seems to indicate that it performs poorly against resistant strains of bacteria and against slow growing organisms. However, the biological plausibility of crosslinking and the lack of effective strategies in managing infections with these organisms continue to focus attention on this potential treatment. Well-conducted experimental and clinical studies with controls are required to answer the questions of its efficacy in future.

  20. Links between nutrition and reproduction in cattle

    International Nuclear Information System (INIS)

    Situations in which nutrition modulates reproductive function, and targets involved, are identified, particularly in relation to initiation of cyclicity (at puberty, during the post-partum period or after induction of ovulation), fertility and induction of ovulation. The usefulness and pertinence of measurements of body weight variations, body condition score, nutritional balance or blood metabolites (glucose, ketone bodies, free fatty acids, cholesterol, urea and amino acids) to evaluate nutritional status in this context is considered. Leptin could play a central role in causal mechanisms linking nutrition and reproduction, in conjunction with somatotropic axis, insulin, opioids, and neuropeptide Y. (author)

  1. Tantalizing Thanatos: unexpected links in death pathways.

    Science.gov (United States)

    Cohen, Isabelle; Castedo, Maria; Kroemer, Guido

    2002-07-01

    Cell death is most frequently the result of apoptosis, an event that is often controlled by mitochondrial membrane permeabilization (MMP). Recent data reveal unexpected functional links between apoptosis and autophagic cell death, in the sense that MMP can trigger autophagy of damaged mitochondria. Conversely, one of the major signal-transducing molecules involved in the activation of autophagy during apoptosis--the so-called DAP kinase--can induce cell death through MMP. Connections are also emerging between apoptosis, autophagy, replicative senescence and cancer-specific metabolic changes. PMID:12185842

  2. The Weak Link Theory of Economic Development

    OpenAIRE

    Jones, Charles I

    2007-01-01

    Per capita income in the richest countries of the world exceeds that in the poorest countries by more than a factor of 50. What explains these enormous differences? This paper returns to an old idea in development economics and proposes that complementarity and linkages are at the heart of the explanation. Just as a chain is only as strong as its weakest link, problems at any point in a production chain can reduce output substantially if inputs enter production in a complementary fashion. Thi...

  3. Academic Information Management: an Open Linking Approach

    OpenAIRE

    Hughes, Gareth; Hall, Wendy; Hey, Tony; Carr, Les

    1999-01-01

    This paper describes a Web based document management system developed as a Lotus Domino application and the continuing research work of providing users with a variety of link services and agents that enhance the basic content of the system. The system is designed for use by administration personnel in an academic environment taking into account the wide variety of systems and methods already in use. Users do not need to know how to author Web pages as the source material for the system are fi...

  4. Radiation cross-linking of montmorillonite/polypropylene composite

    International Nuclear Information System (INIS)

    Polypropylene/montmorillonite composite was prepared via melt compounding process. The dispersion of montmorillonite in the composite was analyzed by XRD (X Ray Diffraction) and TEM (Transmission Electron Microscope). Electronic radiation was applied to the composite in air. The effects of cross-linking agent and montmorillonite on polypropylene cross-linking was studied. The results indicated that cross-linking did not take place in absence of cross-linking agent, while in presence of both cross-linking agent and montmorillonite polypropylene cross-lining occurred in certain radiation dose range. The cross-linked polypropylene/montmorillonite composite exhibited improved mechanical properties. (authors)

  5. Spatial-Operator Algebra For Flexible-Link Manipulators

    Science.gov (United States)

    Jain, Abhinandan; Rodriguez, Guillermo

    1994-01-01

    Method of computing dynamics of multiple-flexible-link robotic manipulators based on spatial-operator algebra, which originally applied to rigid-link manipulators. Aspects of spatial-operator-algebra approach described in several previous articles in NASA Tech Briefs-most recently "Robot Control Based on Spatial-Operator Algebra" (NPO-17918). In extension of spatial-operator algebra to manipulators with flexible links, each link represented by finite-element model: mass of flexible link apportioned among smaller, lumped-mass rigid bodies, coupling of motions expressed in terms of vibrational modes. This leads to operator expression for modal-mass matrix of link.

  6. Research on common issues for relationship between mechanism degree of freedom, driving link and executive link

    Institute of Scientific and Technical Information of China (English)

    WANG AiLun

    2009-01-01

    During engineering practice and theoretical research, the mechanism degree of freedom is sometimes unequal to the number of the driving link, which is unable to be explained according to the classic theory of the mechanism degree of freedom. To solve this problem, the duality description for operating laws of mechanism is introduced based on the concepts of duality. The Junction-Structure Equation is established for the port descriptions of general ideal mechanism and the functional description for the mechanism degree of freedom is described by utilization of bond graph theory. The force-transfer degree of freedom, i.e. the antithesis concept of movement-transfer degree of freedom, is introduced and defined based on the analysis of energy transfer as well as the analysis of signal causality. By utilization of structural description, functional description and duality description for the equation of degree of freedom, the relationship between the movement-transfer degree of freedom and force-transfer degree of freedom is further explored and analyzed. Thus, the relationship between the mechanism degree of freedom upon the driving link and the executive link is described generally. Finally, some typical relationships between the mechanism degree of freedom, the driving link and the executive link are analyzed.

  7. Improving Link Prediction in Intermittently Connected Wireless Networks by Considering Link and Proximity Stabilities

    CERN Document Server

    Zayani, Mohamed-Haykel; Zeghlache, Djamal

    2012-01-01

    Several works have outlined the fact that the mobility in intermittently connected wireless networks is strongly governed by human behaviors as they are basically human-centered. It has been shown that the users' moves can be correlated and that the social ties shared by the users highly impact their mobility patterns and hence the network structure. Tracking these correlations and measuring the strength of social ties have led us to propose an efficient distributed tensor-based link prediction technique. In fact, we are convinced that the feedback provided by such a prediction mechanism can enhance communication protocols such as opportunistic routing protocols. In this paper, we aim to bring out that measuring the stabilities of the link and the proximity at two hops can improve the efficiency of the proposed link prediction technique. To quantify these two parameters, we propose an entropy estimator in order to measure the two stability aspects over successive time periods. Then, we join these entropy esti...

  8. Alpha thalassaemia-mental retardation, X linked

    Directory of Open Access Journals (Sweden)

    Gibbons Richard

    2006-05-01

    Full Text Available Abstract X-linked alpha thalassaemia mental retardation (ATR-X syndrome in males is associated with profound developmental delay, facial dysmorphism, genital abnormalities and alpha thalassaemia. Female carriers are usually physically and intellectually normal. So far, 168 patients have been reported. Language is usually very limited. Seizures occur in about one third of the cases. While many patients are affectionate with their caregivers, some exhibit autistic-like behaviour. Patients present with facial hypotonia and a characteristic mouth. Genital abnormalities are observed in 80% of children and range from undescended testes to ambiguous genitalia. Alpha-thalassaemia is not always present. This syndrome is X-linked recessive and results from mutations in the ATRX gene. This gene encodes the widely expressed ATRX protein. ATRX mutations cause diverse changes in the pattern of DNA methylation at heterochromatic loci but it is not yet known whether this is responsible for the clinical phenotype. The diagnosis can be established by detection of alpha thalassaemia, identification of ATRX gene mutations, ATRX protein studies and X-inactivation studies. Genetic counselling can be offered to families. Management is multidisciplinary: young children must be carefully monitored for gastro-oesophageal reflux as it may cause death. A number of individuals with ATR-X are fit and well in their 30s and 40s.

  9. Linking ecosystem processes to sustainable wetland management

    Science.gov (United States)

    Euliss, Ned H.; Smith, Loren M.; Wilcox, Douglas A.; Browne, Bryant A.

    2009-01-01

    As a result of concern over problems associated with the future of managed wetlands in North America, nearly two dozen wetland scientists and managers met in February 2006 at Bosque del Apache National Wildlife Refuge in New Mexico and discussed a sustainable approach to wetland management. This approach links science with management by focusing on underlying wetland processes. From that meeting, several papers were developed and published in Wetlands to address these concerns (Euliss et al. 2008, Smith et al. 2008, Wilcox 2008). This article summarizes our first paper, Euliss et al. (2008), and a future Newsletter article will summarize Smith et al. (2008). Realization of the role that complex interactions play in maintaining ecosystems, coupled with increasing demands of humans for ecosystem services, has prompted much interest in ecosystem management. Not surprisingly, sustainability of ecosystems has become an explicitly stated goal of many natural resource agencies and, in some cases, has been legislatively mandated to ensure provision of resources for future generations. However, examples of sustainable ecosystem management are uncommon because management goals often focus on specific deliverables rather than processes that sustain ecosystems. This paper has three sections: (1) perspectives in which we provide a bit of history, (2), ecological consequences of a static view, and (3) suggestions to aid wetland managers link management goals with critical ecosystem processes responsible for provision of wetland services.

  10. Links between circadian rhythms and psychiatric disease

    Directory of Open Access Journals (Sweden)

    Ilia N Karatsoreos

    2014-05-01

    Full Text Available Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will hopefully lead to the discovery of treatments to either prevent or alleviate the suffering caused by these diseases. One roadblock to attaining this goal is the realization that neuropsychiatric diseases are rarely due to a single gene polymorphism, environmental exposure, or developmental insult. Rather, it is a complex interaction between these various influences that likely leads to the development of clinically relevant syndromes. Our lab is exploring the links between environmental exposures and neurobehavioral function by investigating how disruption of the circadian (daily clock alters the structure and function of neural circuits, with the hypothesis that disrupting this crucial homeostatic system can directly contribute to altered vulnerability of the organism to other factors that interact to produce psychiatric illness. This review explores some historical and more recent findings that link disrupted circadian clocks to neuropsychiatric disorders, particularly depression, mania, and schizophrenia. We take a comparative approach by exploring the effects observed in human populations, as well as some experimental models used in the laboratory to unravel mechanistic and causal relationships between disruption of the circadian clock and behavioral abnormalities. This is a rich area of research that we predict will contribute greatly to our understanding of how genes, environment, and development interact to modulate an individual’s vulnerability to psychiatric disorders.

  11. Expert communication link management: overview and progress

    Science.gov (United States)

    Dunkelberger, Kirk A.

    1998-08-01

    Consider the downsizing of our forces, the increasing complexity of our tactical platforms, and the ever widening array of communication options and the conclusion is inevitable. The need for automated support to reduce communication-related workload is critical to continued task force effectiveness. In a previous era, communication management expertise resided solely in the form of human experts. These experts flew with the pilots, providing the most effective means of communication in real time; they have since been removed from a great number of platforms due to force downsizing and real estate value in the cockpit. This burden has typically been shifted to the pilot, providing another set of tasks in an environment which is already far too taxing. An Expert Communication Link Manger (ECLM) is required -- a trusted, reliable assistant which can determine optimal link, channel, and waveform data for the communication requirements at hand and translate those requirements transparently into communication device control. Technologies are at hand which make ECLM possible; the mixture of these elements in the correct proportions can provide a capable, deployable, and cost effective ECLM in the near term. This paper describes specific applied ECLM research work in progress funded by the USAF under a four year effort. Operational objectives, technical objectives, a reference design, and technical excursions within the broad ECLM scope will be discussed in detail. Results of prototypes built to date in the area of communication inference from speech understanding, dynamic adaptive routing, and packet switching networks in the tactical environment will be presented.

  12. Perceptual asymmetries and handedness: A neglected link?

    Directory of Open Access Journals (Sweden)

    DanieleMarzoli

    2014-02-01

    Full Text Available Healthy individuals tend to weigh in more the left than the right side of visual space in a variety of contexts, ranging from pseudoneglect to perceptual asymmetries for faces. Among the common explanations proposed for the attentional and perceptual advantages of the left visual field, a link with the prevalence of right-handedness in humans has never been suggested, although some evidence seems to converge in favor of a bias of spatial attention towards the region most likely coincident with another person’s right hand during a face-to-face interaction. Such a bias might imply an increased efficiency in monitoring both communicative and aggressive acts, the right limb being more used than the left in both types of behaviour. Although attentional and perceptual asymmetries could be linked to right-handedness at the level of phylogeny because of the evolutionarily advantage of directing attention towards the region where others’ dominant hand usually operates, it is also legitimate to question whether, at the ontogenetic level, frequent exposure to right-handed individuals may foster leftward biases. These views are discussed in the light of extant literature, and a number of tests are proposed in order to assess our hypotheses.

  13. Communication links for fusion reactor maintenance operations

    International Nuclear Information System (INIS)

    Different architectures are envisaged for data transmission with fibre optic links in a radiation environment, as proposed in literature for both space and high energy physics applications. Their needs and constraints differ from those encountered for maintenance tasks in the future ITER environment, not only in terms of temperature and radiation levels, but also with respect to transmission speed requirements. Our approach attempts to limit the use of radiation-sensitive electronics for transmission of both digital and/or analogue data to the control room, using glass fibres as transport medium. We therefore assessed the radiation behaviour of a cost-effective fibre optic transmitter at 850 nm, consisting of a PWM (pulse width modulator), a radiation tolerant current driver (previously developed at SCK-CEN) and a VCSEL (Vertical-Cavity Surface Emitting Laser assembly, up to 10 MGy at 60 degrees Celsius. The PWM enables to transform an analogue sensor signal into a pseudo numerical signal, with a pulse width proportional to the incoming signal. The main objective of this task is to contribute to the major design of the maintenance equipment and strategy needed for the remote replacement of the divertor system in the future ITER fusion reactor, with particular attention to the implications of radiation hardening rules and recommendations. Next to the radiation assessment studies of remote handling tools, including actuators and sensors, we also develop radiation tolerant communication links with multiplexing capabilities

  14. Harm mediates the disgust-immorality link.

    Science.gov (United States)

    Schein, Chelsea; Ritter, Ryan S; Gray, Kurt

    2016-09-01

    Many acts are disgusting, but only some of these acts are immoral. Dyadic morality predicts that disgusting acts should be judged as immoral to the extent that they seem harmful. Consistent with this prediction, 3 studies reveal that perceived harm mediates the link between feelings of disgust and moral condemnation-even for ostensibly harmless "purity" violations. In many cases, accounting for perceived harm completely eliminates the link between disgust and moral condemnation. Analyses also reveal the predictive power of anger and typicality/weirdness in moral judgments of disgusting acts. The mediation of disgust by harm holds across diverse acts including gay marriage, sex acts, and religious blasphemy. Revealing the endogenous presence and moral relevance of harm within disgusting-but-ostensibly harmless acts argues against modular accounts of moral cognition such as moral foundations theory. Instead, these data support pluralistic conceptions of harm and constructionist accounts of morality and emotion. Implications for moral cognition and the concept of "purity" are discussed. (PsycINFO Database Record PMID:27100369

  15. Porting Inition and Failure to Linked Cheetah

    Energy Technology Data Exchange (ETDEWEB)

    Vitello, P; Souers, P C

    2007-07-18

    Linked CHEETAH is a thermo-chemical code coupled to a 2-D hydrocode. Initially, a quadratic-pressure dependent kinetic rate was used, which worked well in modeling prompt detonation of explosives of large size, but does not work on other aspects of explosive behavior. The variable-pressure Tarantula reactive flow rate model was developed with JWL++ in order to also describe failure and initiation, and we have moved this model into Linked CHEETAH. The model works by turning on only above a pressure threshold, where a slow turn-on creates initiation. At a higher pressure, the rate suddenly leaps to a large value over a small pressure range. A slowly failing cylinder will see a rapidly declining rate, which pushes it quickly into failure. At a high pressure, the detonation rate is constant. A sequential validation procedure is used, which includes metal-confined cylinders, rate-sticks, corner-turning, initiation and threshold, gap tests and air gaps. The size (diameter) effect is central to the calibration.

  16. EarthCube GeoLink: Semantics and Linked Data for the Geosciences

    Science.gov (United States)

    Arko, R. A.; Carbotte, S. M.; Chandler, C. L.; Cheatham, M.; Fils, D.; Hitzler, P.; Janowicz, K.; Ji, P.; Jones, M. B.; Krisnadhi, A.; Lehnert, K. A.; Mickle, A.; Narock, T.; O'Brien, M.; Raymond, L. M.; Schildhauer, M.; Shepherd, A.; Wiebe, P. H.

    2015-12-01

    The NSF EarthCube initiative is building next-generation cyberinfrastructure to aid geoscientists in collecting, accessing, analyzing, sharing, and visualizing their data and knowledge. The EarthCube GeoLink Building Block project focuses on a specific set of software protocols and vocabularies, often characterized as the Semantic Web and "Linked Data", to publish data online in a way that is easily discoverable, accessible, and interoperable. GeoLink brings together specialists from the computer science, geoscience, and library science domains, and includes data from a network of NSF-funded repositories that support scientific studies in marine geology, marine ecosystems, biogeochemistry, and paleoclimatology. We are working collaboratively with closely-related Building Block projects including EarthCollab and CINERGI, and solicit feedback from RCN projects including Cyberinfrastructure for Paleogeosciences (C4P) and iSamples. GeoLink has developed a modular ontology that describes essential geoscience research concepts; published data from seven collections (to date) on the Web as geospatially-enabled Linked Data using this ontology; matched and mapped data between collections using shared identifiers for investigators, repositories, datasets, funding awards, platforms, research cruises, physical specimens, and gazetteer features; and aggregated the results in a shared knowledgebase that can be queried via a standard SPARQL endpoint. Client applications have been built around the knowledgebase, including a Web/map-based data browser using the Leaflet JavaScript library and a simple query service using the OpenSearch format. Future development will include extending and refining the GeoLink ontology, adding content from additional repositories, developing semi-automated algorithms to enhance metadata, and further work on client applications.

  17. DroidLink: Automated Generation of Deep Links for Android Apps

    OpenAIRE

    Ma, Yun; Liu, Xuanzhe; Du, Ruogu; Hu, Ziniu; Liu, Yi; Yu, Meihua; Huang, Gang

    2016-01-01

    The mobile application (app) has become the main entrance to access the Internet on handheld devices. Unlike the Web where each webpage has a global URL to reach directly, a specific "content page" of an app can be opened only by exploring the app with several operations from the landing page. The interoperability between apps is quite fixed and thus limits the value-added "linked data" between apps. Recently, deep link has been proposed to enable targeting and opening a specific page of an a...

  18. Macromolecular Flexibility and Aggregation Tendency of Non-Cross-Linked and Cross-Linked Cationic Polysoaps

    OpenAIRE

    Wang, Guang-Jia; Jan B.F.N. Engberts

    1998-01-01

    The aggregation tendency of non-cross-linked and cross-linked poly(alkylmethyl-diallylammonium halides) bearing n-dodecyl and n-decyl side chains ((CL)-CopolC1-12-Cl, (CL)-CopolC1-12-Br and (CL)-CopolC1-10-Br, respectively) in aqueous solution has been evaluated by measuring their critical aggregate concentration (CAC). Polysoaps (CL)-CopolC1-12-Cl, (CL)-CopolC1-12-Br and (CL)-CopolC1-10-Br all show the same change of their aggregation tendency accompanying an increase in the content of the c...

  19. Genetics Home Reference: X-linked congenital stationary night blindness

    Science.gov (United States)

    ... stationary night blindness X-linked congenital stationary night blindness Enable Javascript to view the expand/collapse boxes. ... Close All Description X-linked congenital stationary night blindness is a disorder of the retina , which is ...

  20. Radiation cross-linking of montmorillonite/polypropylene composite

    International Nuclear Information System (INIS)

    Polypropylene/montmorillonite composite was prepared via melt compounding process. The dispersion of montmorillonite in the composite was analyzed by XRD (X-ray diffraction) and TEM (Transmission electron microscope). Electronic radiation was applied to make the composite radiation cross-linked in air. The effect of cross-linking agent and montmorillonite on the properties of polypropylene cross-linking was studied. The results indicated that cross-linking did not take place in absence of cross-linking agent, while in presence of both cross-linking agent and montmorillonite polypropylene cross-linking occurred in certain absorbed dose range. The cross-linked polypropylene/montmorillonite composite exhibited improved mechanical properties. (authors)

  1. Immune System and Its Link to Rheumatic Diseases

    Science.gov (United States)

    ... Disease The Immune System & Its Link to Rheumatic Disease The Immune System and Its Link to Rheumatic Disease Fast ... cells. This leads to illnesses called autoimmune (self-immune) diseases such as rheumatoid arthritis (inflammation of the joints), ...

  2. Genetics Home Reference: X-linked lymphoproliferative disease

    Science.gov (United States)

    ... 2 links) National Institute of Allergy and Infectious Diseases: Primary Immune Deficiency Diseases National Institute of Allergy and Infectious Diseases: Primary Immune Deficiency Diseases Educational Resources (4 links) Children's Hospital ...

  3. Link Between Money Woes, Domestic Abuse Tough to Untangle

    Science.gov (United States)

    ... gov/medlineplus/news/fullstory_158582.html Link Between Money Woes, Domestic Abuse Tough to Untangle Researchers trying ... 29, 2016 FRIDAY, April 29, 2016 (HealthDay News) -- Money problems and domestic violence appear to be linked, ...

  4. Capacity and Shaping in Coherent Fiber-Optic Links

    DEFF Research Database (Denmark)

    Estaran Tolosa, Jose Manuel; Zibar, Darko; Tafur Monroy, Idelfonso

    2014-01-01

    Over view of the concepts and latest progress of capacity and constellation shaping incoherent optical links.......Over view of the concepts and latest progress of capacity and constellation shaping incoherent optical links....

  5. Genetics Home Reference: X-linked dystonia-parkinsonism

    Science.gov (United States)

    Skip to main content Your Guide to Understanding Genetic Conditions Enable Javascript for addthis links to activate. ... Conditions Genes Chromosomes & mtDNA Resources Help Me Understand Genetics Home Health Conditions X-linked dystonia-parkinsonism X- ...

  6. Great Recession Linked to Weight Gain in Kids

    Science.gov (United States)

    ... nih.gov/medlineplus/news/fullstory_159317.html Great Recession Linked to Weight Gain in Kids Unemployment has ... new study links unemployment during the recent Great Recession with weight gain in children. "This study tells ...

  7. Genetics Home Reference: X-linked sideroblastic anemia and ataxia

    Science.gov (United States)

    ... anemia and ataxia X-linked sideroblastic anemia and ataxia Enable Javascript to view the expand/collapse boxes. ... Close All Description X-linked sideroblastic anemia and ataxia is a rare condition characterized by a blood ...

  8. Analogue photonic link design charts for microwave engineering applications

    OpenAIRE

    Vincent J. Urick

    2015-01-01

    A set of unique design charts for intensity-modulation direct-detection microwave photonics links is presented. The charts facilitate link design and analysis, clearly demonstrating performance trade-offs in terms of standard microwave performance metrics.

  9. HPV-Linked Cancers Still Climbing in U.S.

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_159758.html HPV-Linked Cancers Still Climbing in U.S. Majority of ... Cancers linked to the sexually transmitted human papillomavirus (HPV) keep rising in the United States, even though ...

  10. Genetics Home Reference: X-linked chondrodysplasia punctata 1

    Science.gov (United States)

    Skip to main content Your Guide to Understanding Genetic Conditions Enable Javascript for addthis links to activate. ... Conditions Genes Chromosomes & mtDNA Resources Help Me Understand Genetics Home Health Conditions X-linked chondrodysplasia punctata 1 ...

  11. Link Between Money Woes, Domestic Abuse Tough to Untangle

    Science.gov (United States)

    ... news/fullstory_158582.html Link Between Money Woes, Domestic Abuse Tough to Untangle Researchers trying to determine if ... April 29, 2016 (HealthDay News) -- Money problems and domestic violence appear to be linked, but it's not clear ...

  12. Study IDs 2 Zika Virus Proteins Linked to Microcephaly

    Science.gov (United States)

    ... Study IDs 2 Zika Virus Proteins Linked to Microcephaly Discovery might one day lead to a way ... Zika virus linked to the severe birth defect microcephaly. Babies with microcephaly have abnormally small heads and ...

  13. How different are Wikipedia and web link structure?

    OpenAIRE

    Kamps, J.; Koolen, M

    2010-01-01

    In this paper, we investigate the difference between Wikipedia and Web link structure with respect to their value as indicators of the relevance of a page for a given topic of request. Our main findings are: First, Wikipedia link structure is similar to the Web, but more densely linked. Second, Wikipedia’s outlinks behave similar to inlinks and both are good indicators of relevance, whereas on the Web the inlinks are more important. Third, when incorporating link evidence in the retrieval mod...

  14. Quantum Link Models: A Discrete Approach to Gauge Theories

    OpenAIRE

    Chandrasekharan, S; Wiese, U.-J.

    1996-01-01

    We construct lattice gauge theories in which the elements of the link matrices are represented by non-commuting operators acting in a Hilbert space. These quantum link models are related to ordinary lattice gauge theories in the same way as quantum spin models are related to ordinary classical spin systems. Here U(1) and SU(2) quantum link models are constructed explicitly. As Hamiltonian theories quantum link models are nonrelativistic gauge theories with potential applications in condensed ...

  15. Reconfigurable knots and links in chiral nematic colloids

    OpenAIRE

    Tkalec, Uroš; Ravnik, Miha; Čopar, Simon; Žumer, Slobodan; Muševič, Igor

    2011-01-01

    Tying knots and linking microscopic loops of polymers, macromolecules, or defect lines in complex materials is a challenging task for material scientists. We demonstrate the knotting of microscopic topological defect lines in chiral nematic liquid crystal colloids into knots and links of arbitrary complexity by using laser tweezers as a micromanipulation tool. All knots and links with up to six crossings, including the Hopf link, the Star of David and the Borromean rings are demonstrated, sta...

  16. A Linked Data Platform adapter for the Bugzilla issue tracker

    OpenAIRE

    Mihindukulasooriya, Nandana Sampath; Esteban Gutiérrez, Miguel; García Castro, Raul

    2014-01-01

    The W3C Linked Data Platform (LDP) specification defines a standard HTTP-based protocol for read/write Linked Data and pro- vides the basis for application integration using Linked Data. This paper presents an LDP adapter for the Bugzilla issue tracker and demonstrates how to use the LDP protocol to expose a traditional application as a read/write Linked Data application. This approach provides a exible LDP adoption strategy with minimal changes to existing applications.

  17. LINK OF FISCAL DECENTRALIZATION TO POVERTY REDUCTION: INDONESIAN CONTEXT

    OpenAIRE

    Rr. Sita Dewi Kusumaningrum

    2013-01-01

    Abstract: Link of Fiscal Decentralization to Poverty Reduction: Indonesian Context. It is identified from the literature studies that there are links between fiscal decentralization and poverty reduction. However, the links occurs in different ways among countries and local governments. This is a preliminary study which aims at observing the potential link pattern of fiscal decentralization to poverty reduction in Indonesian provinces before and in the period of fiscal decentralization implem...

  18. Linking Gestures: Cross-Cultural Variation during Instructional Analogies

    Science.gov (United States)

    Richland, Lindsey Engle

    2015-01-01

    Deictic linking gestures, hand and arm motions that physically embody links being communicated between two or more objects in the shared communicative environment, are explored in a cross-cultural sample of mathematics instruction. Linking gestures are specifically examined here when they occur in the context of communicative analogies designed to…

  19. Adaptive control of a manipulator with a flexible link

    Science.gov (United States)

    Yang, Y. P.; Gibson, J. S.

    1988-01-01

    An adaptive controller for a manipulator with one rigid link and one flexible link is presented. The performance and robustness of the controller are demonstrated by numerical simulation results. In the simulations, the manipulator moves in a gravitational field and a finite element model represents the flexible link.

  20. "LinkedIn" for Accounting and Business Students

    Science.gov (United States)

    Albrecht, W. David

    2011-01-01

    LinkedIn is a social media application that every accounting and business student should join and use. LinkedIn is a database of 90,000,000 business professionals that enables each to connect and interact with their business associates. Five reasons are offered for why accounting students should join LinkedIn followed by 11 hints for use.

  1. 47 CFR 54.415 - Consumer qualification for Link Up.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Consumer qualification for Link Up. 54.415... qualification for Link Up. (a) In a state that mandates state Lifeline support, the consumer qualification criteria for Link Up shall be the same as the criteria that the state established for...

  2. Deciding to Change OpenURL Link Resolvers

    Science.gov (United States)

    Johnson, Megan; Leonard, Andrea; Wiswell, John

    2015-01-01

    This article will be of interest to librarians, particularly those in consortia that are evaluating OpenURL link resolvers. This case study contrasts WebBridge (an Innovative Interface product) and LinkSource (EBSCO's product). This study assisted us in the decision-making process of choosing an OpenURL link resolver that was sustainable to…

  3. Turbulent single-photon propagation in the Canary optical link

    Energy Technology Data Exchange (ETDEWEB)

    Capraro, Ivan; Tomaello, Andrea; Dall' Arche, Alberto; Gerlin, Francesca; Vallone, Giuseppe; Villoresi, Paolo [Department of Information Engineering, University of Padova, Padova (Italy); Herbst, Thomas [Vienna Center for Quantum Science and Technology (VCQ), Faculty of Physics, University of Vienna, Vienna (Austria); Ursin, Rupert [IQOQI - Institute for Quantum Optics and Quantum Information, Austrian Academy of Sciences, Vienna (Austria)

    2014-12-04

    The role of turbulence for Quantum Communications (QC) has been investigated in a 143 km-long link. The analysis of the received signal temporal domain indicate how to exploit constructively its effects in the case of QC along very long free-space links as well satellite links. Novel applications with relevant background noise may be envisaged.

  4. 21 CFR 177.2420 - Polyester resins, cross-linked.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Polyester resins, cross-linked. 177.2420 Section... as Components of Articles Intended for Repeated Use § 177.2420 Polyester resins, cross-linked. Cross-linked polyester resins may be safely used as articles or components of articles intended for...

  5. The Self-Linking Number in Planar Open Book Decompositions

    CERN Document Server

    Kawamuro, Keiko

    2011-01-01

    We find a self-linking number formula for a given null-homologous transverse link in a contact manifold that is compatible with a planar open book decomposition. It extends Bennequin's self-linking formula for a braid in the standard contact 3-sphere.

  6. Detecting and Reporting Extensional Concept Drift in Statistical Linked Data

    NARCIS (Netherlands)

    A. Meroño-Peñuela; C. Guéret; R. Hoekstra; S. Schlobach

    2013-01-01

    The RDF Data Cube vocabulary is a catalyst for the availability of statistical Linked Data: raw statistical Linked Data are easy to model in, publish to, and retrieve from the Linked Data cloud. In statistical datasets, concepts are central entities represented by variables and their values. The mea

  7. 21 CFR 177.1211 - Cross-linked polyacrylate copolymers.

    Science.gov (United States)

    2010-04-01

    ... polyacrylate copolymers consist of: (1) The grafted copolymer of cross-linked sodium polyacrylate identified as... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Cross-linked polyacrylate copolymers. 177.1211... Basic Components of Single and Repeated Use Food Contact Surfaces § 177.1211 Cross-linked...

  8. REDEN: Named Entity Linking in Digital Literary Editions Using Linked Data Sets

    Directory of Open Access Journals (Sweden)

    Carmen Brando

    2016-07-01

    Full Text Available This paper proposes a graph-based Named Entity Linking (NEL algorithm named REDEN for the disambiguation of authors’ names in French literary criticism texts and scientific essays from the 19th and early 20th centuries. The algorithm is described and evaluated according to the two phases of NEL as reported in current state of the art, namely, candidate retrieval and candidate selection. REDEN leverages knowledge from different Linked Data sources in order to select candidates for each author mention, subsequently crawls data from other Linked Data sets using equivalence links (e.g., owl:sameAs, and, finally, fuses graphs of homologous individuals into a non-redundant graph well-suited for graph centrality calculation; the resulting graph is used for choosing the best referent. The REDEN algorithm is distributed in open-source and follows current standards in digital editions (TEI and semantic Web (RDF. Its integration into an editorial workflow of digital editions in Digital humanities and cultural heritage projects is entirely plausible. Experiments are conducted along with the corresponding error analysis in order to test our approach and to help us to study the weaknesses and strengths of our algorithm, thereby to further improvements of REDEN.

  9. Optimal spatial transportation networks where link costs are sublinear in link capacity

    International Nuclear Information System (INIS)

    Consider designing a transportation network on n vertices in the plane, with traffic demand uniform over all source–destination pairs. Suppose the cost of a link of length l and capacity c scales as lcβ for fixed 0α(β), where α(β) = 1−(β/2) on 0βsγ

  10. Synthesis of dye linked conducting block copolymers, dye linked conducting homopolymers and preliminary application to photovoltaics

    DEFF Research Database (Denmark)

    Krebs, Frederik C; Hagemann, O.; Jørgensen, M.

    2004-01-01

    A synthetic approach to the synthesis of a large super molecule composed of two chemically different conducting polymer blocks with, respectively, high and low lying electronic energy levels linked through a porphyrin dye molecule is presented. The synthetic strategies to these molecular...

  11. Linking advanced fracture models to structural analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chiesa, Matteo

    2001-07-01

    Shell structures with defects occur in many situations. The defects are usually introduced during the welding process necessary for joining different parts of the structure. Higher utilization of structural materials leads to a need for accurate numerical tools for reliable prediction of structural response. The direct discretization of the cracked shell structure with solid finite elements in order to perform an integrity assessment of the structure in question leads to large size problems, and makes such analysis infeasible in structural application. In this study a link between local material models and structural analysis is outlined. An ''ad hoc'' element formulation is used in order to connect complex material models to the finite element framework used for structural analysis. An improved elasto-plastic line spring finite element formulation, used in order to take cracks into account, is linked to shell elements which are further linked to beam elements. In this way one obtain a global model of the shell structure that also accounts for local flexibilities and fractures due to defects. An important advantage with such an approach is a direct fracture mechanics assessment e.g. via computed J-integral or CTOD. A recent development in this approach is the notion of two-parameter fracture assessment. This means that the crack tip stress tri-axiality (constraint) is employed in determining the corresponding fracture toughness, giving a much more realistic capacity of cracked structures. The present thesis is organized in six research articles and an introductory chapter that reviews important background literature related to this work. Paper I and II address the performance of shell and line spring finite elements as a cost effective tool for performing the numerical calculation needed to perform a fracture assessment. In Paper II a failure assessment, based on the testing of a constraint-corrected fracture mechanics specimen under tension, is

  12. New links between Ecuador and CERN

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    A new protocol recently signed in Quito opens the way to stronger links between the Ecuadorian scientific community and CERN. The operational framework provided by the protocol will enable scientists from Ecuador to take part in CERN’s projects, supported by the Ecuadorian authorities.   Picture taken during the signing ceremony at SENESCYT (Quito, Ecuador) on 12 July 2011. From left to right: Guillermo Solórzano, Minister for Coordination of Knowledge and Human Talent, Rene Ramirez Gallegos, National Secretary for Higher Education, Science and Technology - SENECYT, Felicitas Pauss and Jose Salicio from CERN. Ecuador’s involvement with CERN dates back to 1999 when a first International Co-operation Agreement was signed. However, despite these early beginnings,   only a few scientists from Ecuador, affiliated to non-Ecuadorian institutes, have since been directly involved in CERN’s projects, in particular the CMS experiment a...

  13. Sharing Epigraphic Information as Linked Data

    Science.gov (United States)

    Álvarez, Fernando-Luis; García-Barriocanal, Elena; Gómez-Pantoja, Joaquín-L.

    The diffusion of epigraphic data has evolved in the last years from printed catalogues to indexed digital databases shared through the Web. Recently, the open EpiDoc specifications have resulted in an XML-based schema for the interchange of ancient texts that uses XSLT to render typographic representations. However, these schemas and representation systems are still not providing a way to encode computational semantics and semantic relations between pieces of epigraphic data. This paper sketches an approach to bring these semantics into an EpiDoc based schema using the Ontology Web Language (OWL) and following the principles and methods of information sharing known as "linked data". The paper describes the general principles of the OWL mapping of the EpiDoc schema and how epigraphic data can be shared in RDF format via dereferenceable URIs that can be used to build advanced search, visualization and analysis systems.

  14. Hypothyroidism and obesity: An intriguing link

    Directory of Open Access Journals (Sweden)

    Debmalya Sanyal

    2016-01-01

    Full Text Available According to common perception, hypothyroidism is held responsible for obesity. However, linking them causally is controversial. Overt hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism. Novel view indicates that changes in thyroid-stimulating hormone (TSH could well be secondary to obesity. The increasing prevalence of obesity further confounds definition of normal TSH range in population studies. Thyroid autoantibody status may help in establishing the diagnosis of subclinical hypothyroidism in obesity. High leptin levels may play a role in the hyperthyrotropinemia of obesity and also increase susceptibility to thyroid autoimmunity and subsequent hypothyroidism. There is at most a modest effect of L-T4 treatment in overt hypothyroidism in inducing weight loss; benefit in subclinical hypothyroidism is not established with no data supporting thyroid hormone use in euthyroid obese patients.

  15. A Review of Algebraic Link Analysis Algorithms

    Directory of Open Access Journals (Sweden)

    Mini Singh Ahuja

    2012-08-01

    Full Text Available The World Wide Web is a system of interlinked hypertext documents accessed via the Internet. With a web browser, one can view web pages that may contain text, images, videos, and other multimedia and navigate between them by using hyperlinks. Navigation is the process through which the users can achieve their purposes in using Web site, such as to find the information that they need or to complete the transactions that they want to do. Web mining is the application of data mining techniques to extract knowledge from Web data, where at least one of structure (hyperlink or usage (Web log data is used in the mining process (with or without other types of Web data. In this paper we have briefly discussed the web mining technique with major stress to the link analysis algorithms.

  16. Riboflavin for corneal cross-linking.

    Science.gov (United States)

    O'Brart, D P S

    2016-06-01

    Corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A (UVA) radiation is the first therapeutic modality that appears to arrest the progression of keratoconus and other corneal ectasias. Riboflavin is central to the process, acting as a photosensitizer for the production of oxygen singlets and riboflavin triplets. These free radicals drive the CXL process within the proteins of the corneal stroma, altering its biomechanical properties. Riboflavin also absorbs the majority of the UVA radiation, which is potentially cytotoxic and mutagenic, within the anterior stroma, preventing damage to internal ocular structures, such as the corneal endothelium, lens and retina. Clinical studies report cessation of ectatic progression in over 90% of cases and the majority document significant improvements in visual, keratometric and topographic parameters. Clinical follow-up is limited to 5-10 years, but suggests sustained stability and enhancement in corneal shape. Sight-threatening complications are rare. The optimal stromal riboflavin dosage for CXL is as yet undetermined. PMID:27458610

  17. Applying Linked Data Technologies for Online Newspapers

    Directory of Open Access Journals (Sweden)

    Tsvetanka Georgieva-Trifonova

    2015-05-01

    Full Text Available The constantly growing data volume at the companies along with the necessity for finding information for the shortest possible time span involves methods of information search different from the ones conventionally used. The semantic technologies, developed in the late 90s and the beginning of the new century, are viewed as a new generation of databases and as text analyzing technologies. The present paper deals with researching the opportunities and examining the advantages of applying the semantic web technologies and the linked data for online newspapers. Besides, a RDF-based ontology for the purposes of a system for study and evaluation of online editions of regional daily newspapers is proposed. SPARQL endpoint is implemented to access the RDF data.

  18. Alexander quandle lower bounds for link genera

    OpenAIRE

    Benedetti, Riccardo; Frigerio, Roberto

    2011-01-01

    We denote by Q_F the family of the Alexander quandle structures supported by finite fields. For every k-component oriented link L, every partition P of L into h:=|P| sublinks, and every labelling z of such a partition by the natural numbers z_1,...,z_n, the number of X-colorings of any diagram of (L,z) is a well-defined invariant of (L,P), of the form q^(a_X(L,P,z)+1) for some natural number a_X(L,P,z). Letting X and z vary in Q_F and among the labellings of P, we define a derived invariant A...

  19. Hypothyroidism and obesity: An intriguing link

    Science.gov (United States)

    Sanyal, Debmalya; Raychaudhuri, Moutusi

    2016-01-01

    According to common perception, hypothyroidism is held responsible for obesity. However, linking them causally is controversial. Overt hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism. Novel view indicates that changes in thyroid-stimulating hormone (TSH) could well be secondary to obesity. The increasing prevalence of obesity further confounds definition of normal TSH range in population studies. Thyroid autoantibody status may help in establishing the diagnosis of subclinical hypothyroidism in obesity. High leptin levels may play a role in the hyperthyrotropinemia of obesity and also increase susceptibility to thyroid autoimmunity and subsequent hypothyroidism. There is at most a modest effect of L-T4 treatment in overt hypothyroidism in inducing weight loss; benefit in subclinical hypothyroidism is not established with no data supporting thyroid hormone use in euthyroid obese patients. PMID:27366725

  20. Improving Schema Matching with Linked Data

    CERN Document Server

    Assaf, Ahmad; Senart, Aline; Follenfant, Corentin; Troncy, Raphaël; Trastour, David

    2012-01-01

    With today's public data sets containing billions of data items, more and more companies are looking to integrate external data with their traditional enterprise data to improve business intelligence analysis. These distributed data sources however exhibit heterogeneous data formats and terminologies and may contain noisy data. In this paper, we present a novel framework that enables business users to semi-automatically perform data integration on potentially noisy tabular data. This framework offers an extension to Google Refine with novel schema matching algorithms leveraging Freebase rich types. First experiments show that using Linked Data to map cell values with instances and column headers with types improves significantly the quality of the matching results and therefore should lead to more informed decisions.

  1. Problem Based Learning - Linking Students and Industry

    DEFF Research Database (Denmark)

    Fink, Flemming K.

    2006-01-01

    -oriented project work: students work in teams to solve externally defined problem areas in co-operation with businesses, organisations and public institutions. Project Organised Problem Based Learning (POPBL) has generated a high degree of cooperation with the society and private companies. There are all the time......WG2_G4 Problem based learning – linking students and industry: a case study from Aalborg, Denmark Flemming K. Flink ELITE Aalborg University In Aalborg University, Denmark, all study programmes are organised around inter-disciplinary project work in groups. Up to 50% of the study work is problem...... is essentially problem solving. The presentation looks into on campus POPBL and the Facilitated Work Based Learning (FBL) for continuing education. It also presents case examples of POPBL work....

  2. Public Space Design - linking wayfinding and wayfaring

    DEFF Research Database (Denmark)

    Lanng, Ditte Bendix; Jensen, Ole B.

    2016-01-01

    ’ framework the chapter addresses key concepts to approach how wayfinding and wayfaring are linked in ordinary mobile situations in public space. The diverse design considerations that begin to materialize in this conceptual linkage can be integrated within the emerging field of ‘mobilities design’, which......This chapter, written from an urban design perspective, concerns the relation between daily life traveling and public space design. While travelers are sometimes set on traveling as fast as possible between point A and point B in smooth and unambiguous ways, at other times they may be inclined to...... engage in a wide range of social encounters and sensorial experiences while on the way. The concepts of wayfinding and wayfaring, respectively, embrace diverse considerations for public space design to ‘stage’ such diverse mobile situations. Wayfinding, as defined by Lynch in 1960, emphasizes the...

  3. Hypothyroidism and obesity: An intriguing link.

    Science.gov (United States)

    Sanyal, Debmalya; Raychaudhuri, Moutusi

    2016-01-01

    According to common perception, hypothyroidism is held responsible for obesity. However, linking them causally is controversial. Overt hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism. Novel view indicates that changes in thyroid-stimulating hormone (TSH) could well be secondary to obesity. The increasing prevalence of obesity further confounds definition of normal TSH range in population studies. Thyroid autoantibody status may help in establishing the diagnosis of subclinical hypothyroidism in obesity. High leptin levels may play a role in the hyperthyrotropinemia of obesity and also increase susceptibility to thyroid autoimmunity and subsequent hypothyroidism. There is at most a modest effect of L-T4 treatment in overt hypothyroidism in inducing weight loss; benefit in subclinical hypothyroidism is not established with no data supporting thyroid hormone use in euthyroid obese patients. PMID:27366725

  4. THE LINK BETWEEN ACCOUNTING AND FISCAL EVASION

    Directory of Open Access Journals (Sweden)

    Silvia Lăzărescu (Marinescu

    2008-12-01

    Full Text Available In the literature, controversies have arisen concerning the link between accounting and fiscal evasion, which are the object of debates among specialists from different specialized organizations from many countries. Under the term of “creative accounting”, the American and European tax systems have made up an ensemble of accounting mechanisms and also of fiscal manipulation which increased the interest and involvement of the states in the mitigation of such fraud risks and fiscal subterfuges whose percentage in the countries’ GDP varies from 8 to 80%. Starting from the SWOT analysis of tax evasion in the real and underground economy, the specialists of the liberal trades are called to join the fight against fiscal fraud and share their professionalism in creating a real competitive environment characterized by fair play.

  5. Linking Science Fiction and Physics Courses

    Science.gov (United States)

    McBride, Krista K.

    2016-05-01

    Generally, cohorts or learning communities enrich higher learning in students. Learning communities consist of conventionally separate groups of students that meet together with common academic purposes and goals. Types of learning communities include paired courses with concurrent student enrollment, living-learning communities, and faculty learning communities. This article discusses a learning community of 21 students that I created with a colleague in the English department. The community encompasses two general education courses: an algebra-based physics course entitled "Intro to Physics" and a literature course entitled "Science Fiction, Science Fact." Students must enroll in both of these courses during the same semester. Additionally, I highlight advantages to linking these courses through surveying the assignments and course materials that we used in our learning community. Figure 1 shows the topics that are covered in both physics and literature courses.

  6. Robust bidirectional links for photonic quantum networks.

    Science.gov (United States)

    Xu, Jin-Shi; Yung, Man-Hong; Xu, Xiao-Ye; Tang, Jian-Shun; Li, Chuan-Feng; Guo, Guang-Can

    2016-01-01

    Optical fibers are widely used as one of the main tools for transmitting not only classical but also quantum information. We propose and report an experimental realization of a promising method for creating robust bidirectional quantum communication links through paired optical polarization-maintaining fibers. Many limitations of existing protocols can be avoided with the proposed method. In particular, the path and polarization degrees of freedom are combined to deterministically create a photonic decoherence-free subspace without the need for any ancillary photon. This method is input state-independent, robust against dephasing noise, postselection-free, and applicable bidirectionally. To rigorously quantify the amount of quantum information transferred, the optical fibers are analyzed with the tools developed in quantum communication theory. These results not only suggest a practical means for protecting quantum information sent through optical quantum networks but also potentially provide a new physical platform for enriching the structure of the quantum communication theory. PMID:26824069

  7. Renal cell carcinoma: links and risks.

    Science.gov (United States)

    Kabaria, Reena; Klaassen, Zachary; Terris, Martha K

    2016-01-01

    This review provides an overview of the incidence of renal cell carcinoma (RCC) and a summary of the most commonly associated risk factors. A literature review was performed with a focus on recent studies with a high level of evidence (large prospective cohort studies and meta-analyses). The incidence rate of RCC varies globally, with the rate rising rapidly in more developed regions, demonstrating the effects of increased use of diagnostic imaging and prevalence of modifiable risk factors. Based on the current evidence, cigarette smoking, obesity, and hypertension are the most well-established risk factors for sporadic RCC worldwide. Acquired cystic kidney disease is also a significant risk factor, specifically in dialysis patients. There is increasing evidence for an inverse association between RCC risk and moderate alcohol consumption. Certain analgesics and occupational exposure have been linked to an increased risk of RCC, although data are limited. Diets rich in fruits and vegetables may provide a protective effect. PMID:27022296

  8. Identifying links between origami and compliant mechanisms

    Directory of Open Access Journals (Sweden)

    H. C. Greenberg

    2011-12-01

    Full Text Available Origami is the art of folding paper. In the context of engineering, orimimetics is the application of folding to solve problems. Kinetic origami behavior can be modeled with the pseudo-rigid-body model since the origami are compliant mechanisms. These compliant mechanisms, when having a flat initial state and motion emerging out of the fabrication plane, are classified as lamina emergent mechanisms (LEMs. To demonstrate the feasibility of identifying links between origami and compliant mechanism analysis and design methods, four flat folding paper mechanisms are presented with their corresponding kinematic and graph models. Principles from graph theory are used to abstract the mechanisms to show them as coupled, or inter-connected, mechanisms. It is anticipated that this work lays a foundation for exploring methods for LEM synthesis based on the analogy between flat-folding origami models and linkage assembly.

  9. Neutropenia Associated with X-Linked Agammaglobulinemia

    Directory of Open Access Journals (Sweden)

    Aghamohammadi Asghar

    2009-03-01

    Full Text Available X-linked Agammaglobulinemia (XLA is a hereditary immunodeficiency, characterized by an early onset of recurrent bacterial infections, hypogammaglobulinemia and markedly reduced B lymphocytes number. In order to determine the association of neutropenia among Iranian patients with XLA, hospital records of 30 patients with confirmed XLA in Children Medical Center Hospital, were reviewed. Eight out of 30 XLA patients (26.7% developed neutropenia during the course of the disease. In two patients, episodes of neutropenia were identified before or at the time of diagnosis of XLA. Other six patients whom were not visited regularly and did not receive periodical immunoglobulin replacement therapy experienced neutropenia after diagnosis of XLA. Neutropenia in XLA is mainly associated with infection and is resolved with intravenous immunoglobulin replacement and antibiotics therapy.

  10. Linking ecosystem services with cultural landscape research

    DEFF Research Database (Denmark)

    Schaich, Harald; Biding, Claudia; Plieninger, Tobias

    2010-01-01

    The concept of ecosystem services facilitates the valuation of the multiple services from ecosystems and landscapes, the identification of trade-offs between different land use scenarios, and also informs decision making in land use planning. Unfortunately, cultural services have been mostly...... cultural services. In this paper, we compare the objectives, approaches, and methodologies adopted by ecosystem services research and cultural landscape research through a bibliographic research. Both research communities investigate the human dimension of ecosystems and landscapes and, hence, study the...... same object. A closer link between the two research communities would enrich and possibly sharpen both approaches. In particular, landscape research on cultural services such as aesthetics or cultural heritage could provide valuable results and methods for a comprehensive assessment of ecosystem...

  11. Npas4: Linking Neuronal Activity to Memory.

    Science.gov (United States)

    Sun, Xiaochen; Lin, Yingxi

    2016-04-01

    Immediate-early genes (IEGs) are rapidly activated after sensory and behavioral experience and are believed to be crucial for converting experience into long-term memory. Neuronal PAS domain protein 4 (Npas4), a recently discovered IEG, has several characteristics that make it likely to be a particularly important molecular link between neuronal activity and memory: it is among the most rapidly induced IEGs, is expressed only in neurons, and is selectively induced by neuronal activity. By orchestrating distinct activity-dependent gene programs in different neuronal populations, Npas4 affects synaptic connections in excitatory and inhibitory neurons, neural circuit plasticity, and memory formation. It may also be involved in circuit homeostasis through negative feedback and psychiatric disorders. We summarize these findings and discuss their implications. PMID:26987258

  12. Smart POI: Open and linked spatial data

    Science.gov (United States)

    Cerba, Otakar; Berzins, Raitis; Charvat, Karel; Mildorf, Tomas

    2016-04-01

    The Smart Point of Interest (SPOI) represents an unique seamless spatial data set based on standards recommended for Linked and open data, which are supported by scientist and researchers as well as by several government authorities and European Union. This data set developed in cooperation of partners of SDI4Apps project contains almost 24 millions points of interest focused mainly on tourism, natural features, transport or citizen services. The SPOI data covers almost all countries and territories over the world. It is created as a harmonized combination of global data resources (selected points from OpenStreetMap, Natural Earth and GeoNames.org) and several local data sets (for example data published by the Citadel on the Move project, data from Posumavi region in the Czech Republic or experimental ontologies developed in the University of West Bohemia including ski regions in Europe or historical sights in Rome). The added value of the SDI4Apps approach in comparison to other similar solutions consists in implementation of linked data approach (several objects are connected to DBpedia or GeoNames.org), using of universal RDF format, using of standardized and respected properties or vocabularies (for example FOAF or GeoSPARQL) and development of the completely harmonized data set with uniform data model and common classification (not only a copy of original resources). The SPOI data is published as SPARQL endpoint as well as in the map client. The SPOI dataset is a specific set of POIs which could be "a data fuel" for applications and services related to tourism, local business, statistics or landscape monitoring. It can be used also as a background data layer for thematic maps.

  13. X-linked cardiomyopathy is heterogeneous

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, M.J.; Sillence, D.O.; Mulley, J.C. [and others

    1994-09-01

    Two major loci of X-linked cardiomyopathy have been mapped by linkage analysis. The gene for X-linked dilated cardiomyopathy (XLCM) is mapped to the dystrophin locus at Xp21, while Barth syndrome has been localised to distal Xq28. XLCM usually presents in juvenile males with no skeletal disease but decreased dystrophin in cardiac muscle. Barth syndrome most often presents in infants and is characterized by skeletal myopathy, short stature and neutropenia in association with cardiomyopathy of variable severity. Prior to carrier or prenatal diagnosis in a family, delineation of the cardiomyopathy locus involved is essential. We report the linkage mapping of a large kindred in which several male infants have died with hypertrophic cardiomyopathy. There is a family history of unexplained death of infant males less than 6 months old over 4 generations. Features of Barth syndrome such as short stature, skeletal myopathy and neutropenia have not been observed. Genotyping at 10 marker loci in Xq28 has revealed significant pairwise lod scores with the cardiomyopathy phenotype at DXS52 (Z=2.21 at {theta}=0.0), at markers p26 and p39 near DXS15 (Z=2.30 at {theta}=0.0) and at F8C (Z=2.24 at {theta}=0.0). A recombinant detected with DXS296 defines the proximal limit to the localization. No recombinants were detected at any of the loci distal to DXS296. The most distal marker in Xq28, DXS1108, is within 500 kb of the telomere. As the gene in this family is localized to Xq28, it is possible that this disorder is an allelic variant at the Barth syndrome locus.

  14. Braiding surface links which are coverings over the standard torus

    OpenAIRE

    NAKAMURA, Inasa

    2009-01-01

    We consider a surface link in the 4-space which can be presented by a simple branched covering over the standard torus, which we call a torus-covering link. Torus-covering links include spun $T^2$-knots and turned spun $T^2$-knots. In this paper we braid a torus-covering link over the standard 2-sphere. This gives an upper estimate of the braid index of a torus-covering link. In particular we show that the turned spun $T^2$-knot of the torus $(2,\\,p)$-knot has the braid index four.

  15. Linked Vocabulary API for the Earth Sciences Community

    Science.gov (United States)

    Zednik, S.; Fox, P. A.; Fu, L.; West, P.; Ma, X.

    2014-12-01

    The Linked Vocabulary API is a specification for publishing RESTful APIs of vocabularies represented in the Simple Knowledge Organization System (SKOS) as Linked Data on the web. This work began as part of the Coastal and Marine Spatial Planning Vocabularies (CMSPV) project in response to the need for a standard manner for agencies to publish and consume hierarchical vocabularies on the web. The RESTful architecture of the API provides a simple mechanism for consumption of full vocabularies, single vocabulary terms, related terms, and searches on terms. The Linked Data nature of the API promotes interoperability by exposing vocabulary resources as resolvable URIs that may be referenced from other vocabularies or sources of Linked Data and by allowing the published vocabulary to contain references as links to terms from other vocabularies. The Linked Vocabulary API is formally defined in a Linked Data API specification and may be deployed using standard implementations of the Linked Data API such as the Epimorphics Linked Data API (ELDA). Recent presentations of work done with the Linked Vocabulary API as part of the CMSPV project have resulted in the API receiving growing interest from the broader scientific community. In this contribution we present the Linked Vocabulary API design and deployment process.

  16. Problem Formulation and Analysis of the 1-Hop ARQ Links

    Science.gov (United States)

    Cheung, K.-M.

    2013-08-01

    In space communications, standard link analysis assumes that messages are sent once. For a communication link that uses an error-correction coding scheme, bit-error rate (BER) or frame-error rate (FER), and link margins are common metrics that characterize the quality of a link, and they are used to determine the supportable data rate. With the advent of Automatic Repeat-reQuest (ARQ) protocols, when messages are corrupted during transmission, they can be resent multiple times automatically until they are correctly received and acknowledged. The concept of BER, FER, and link margin cannot be directly applied, and the link analysis approach for ARQ links needs to be reexamined. In this article, we provide the problem formulation and extend the standard link analysis approach to a 1-hop ARQ link (no routing), under the assumption that code-block errors occur independently as in the case of space communications. We develop analytical models that describe the statistical behavior of standard 1-hop ARQ links. By integrating these analytical ARQ protocol models into the standard link analysis, we bypass the need to simulate or emulate the ARQ protocol operations, and generate relevant statistics on effective data rate, effective throughput, latency, and FER.

  17. Critical links and nonlocal rerouting in complex supply networks

    CERN Document Server

    Witthaut, Dirk; Zhang, Xiaozhu; Hallerberg, Sarah; Timme, Marc

    2015-01-01

    Link failures repeatedly induce large-scale outages in power grids and other supply networks. Yet, it is still not well understood, which links are particularly prone to inducing such outages. Here we analyze how the nature and location of each link impact the network's capability to maintain stable supply. We propose two criteria to identify critical links on the basis of the topology and the load distribution of the network prior to link failure. They are determined via a link's redundant capacity and a renormalized linear response theory we derive. These criteria outperform critical link prediction based on local measures such as loads. The results not only further our understanding of the physics of supply networks in general. As both criteria are available before any outage from the state of normal operation, they may also help real-time monitoring of grid operation, employing counter-measures and support network planning and design.

  18. Critical Links and Nonlocal Rerouting in Complex Supply Networks.

    Science.gov (United States)

    Witthaut, Dirk; Rohden, Martin; Zhang, Xiaozhu; Hallerberg, Sarah; Timme, Marc

    2016-04-01

    Link failures repeatedly induce large-scale outages in power grids and other supply networks. Yet, it is still not well understood which links are particularly prone to inducing such outages. Here we analyze how the nature and location of each link impact the network's capability to maintain a stable supply. We propose two criteria to identify critical links on the basis of the topology and the load distribution of the network prior to link failure. They are determined via a link's redundant capacity and a renormalized linear response theory we derive. These criteria outperform the critical link prediction based on local measures such as loads. The results not only further our understanding of the physics of supply networks in general. As both criteria are available before any outage from the state of normal operation, they may also help real-time monitoring of grid operation, employing countermeasures and support network planning and design. PMID:27082006

  19. The linking number in systems with Periodic Boundary Conditions

    Science.gov (United States)

    Panagiotou, E.

    2015-11-01

    Periodic Boundary Conditions (PBC) are often used for the simulation of complex physical systems. Using the Gauss linking number, we define the periodic linking number as a measure of entanglement for two oriented curves in a system employing PBC. In the case of closed chains in PBC, the periodic linking number is an integer topological invariant that depends on a finite number of components in the periodic system. For open chains, the periodic linking number is an infinite series that accounts for all the topological interactions in the periodic system. In this paper we give a rigorous proof that the periodic linking number is defined for the infinite system, i.e., that it converges for one, two, and three PBC models. It gives a real number that varies continuously with the configuration and gives a global measure of the geometric complexity of the system of chains. Similarly, for a single oriented chain, we define the periodic self-linking number and prove that it also is defined for open chains. In addition, we define the cell periodic linking and self-linking numbers giving localizations of the periodic linking numbers. These can be used to give good estimates of the periodic linking numbers in infinite systems. We also define the local periodic linking number associated to chains in the immediate cell neighborhood of a chain in order to study local linking measures in contrast to the global linking measured by the periodic linking numbers. Finally, we study and compare these measures when applied to a PBC model of polyethylene melts.

  20. Browsing and Visualization of Linked Environmental Data

    Science.gov (United States)

    Nikolaou, Charalampos; Kyzirakos, Kostis; Bereta, Konstantina; Dogani, Kallirroi; Koubarakis, Manolis

    2014-05-01

    Linked environmental data has started to appear on the Web as environmental researchers make use of technologies such as ontologies, RDF, and SPARQL. Many of these datasets have an important geospatial and temporal dimension. The same is true also for the Web of data that is being rapidly populated not only with geospatial information, but also with temporal information. As the real-world entities represented in linked geospatial datasets evolve over time, the datasets themselves get updated and both the spatial and the temporal dimension of data become significant for users. For example, in the Earth Observation and Environment domains, data is constantly produced by satellite sensors and is associated with metadata containing, among others, temporal attributes, such as the time that an image was acquired. In addition, the acquisitions are considered to be valid for specific periods of time, for example until they get updated by new acquisitions. Satellite acquisitions might be utilized in applications such as the CORINE Land Cover programme operated by the European Environment Agency that makes available as a cartographic product the land cover of European areas. Periodically CORINE publishes the changes in the land cover of these areas in the form of changesets. Tools for exploiting the abundance of geospatial information have also started to emerge. However, these tools are designed for browsing a single data source, while in addition they cannot represent the temporal dimension. This is for two reasons: a) the lack of an implementation of a data model and a query language with temporal features covering the various semantics associated with the representation of time (e.g., valid and user-defined), and b) the lack of a standard temporal extension of RDF that would allow practitioners to utilize when publishing RDF data. Recently, we presented the temporal features of the data model stRDF, the query language stSPARQL, and their implementation in the geospatial