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Sample records for carboxykinase links anaplerosis

  1. The regulation of phosphoenolpyruvate carboxykinase and the NADP-linked malic enzyme in Aspergillus nidulans.

    Science.gov (United States)

    Kelly, J M; Hynes, M J

    1981-04-01

    It has previously been suggested that the synthesis of phosphoenolpyruvate carboxykinase (EC 4.1.1.32) in Aspergillus nidulans is regulated by a repression-derepression mechanism involving a glycolytic intermediate, and not by induction. Results obtained using compounds that enter the tricarboxylic acid cycle via 2-oxoglutarate, and that can supply both a carbon and a nitrogen source for A. nidulans, suggest it is more likely that the synthesis of phosphoenolpyruvate carboxykinase is inducible, and only weakly regulated by carbon catabolite repression. a similar study of the regulation of the NADP-linked malic enzyme (EC 1.1.1.40) indicates that it too may be inducible.

  2. Cardiac anaplerosis in health and disease: food for thought.

    Science.gov (United States)

    Des Rosiers, Christine; Labarthe, François; Lloyd, Steven G; Chatham, John C

    2011-05-01

    There has been a resurgence of interest for the field of cardiac metabolism catalysed by the increased need for new therapeutic targets for patients with heart failure. The primary focus of research in this area to date has been on the impact of substrate selection for oxidative energy metabolism; however, anaplerotic metabolism also has significant interest for its potential cardioprotective role. Anaplerosis refers to metabolic pathways that replenish the citric acid cycle intermediates, which are essential to energy metabolism; however, our understanding of the role and regulation of this process in the heart, particularly under pathophysiological conditions, is very limited. Therefore, the goal of this article is to provide a foundation for future directions of research on cardiac anaplerosis and heart disease. We include an overview of anaplerotic metabolism, a critical evaluation of current methods available for its quantitation in the intact heart, and a discussion of its role and regulation both in health and disease as it is currently understood based mostly on animal studies. We also consider genetic diseases affecting anaplerotic pathways in humans and acute intervention studies with anaplerotic substrates in the clinics. Finally, as future perspectives, we will share our thoughts about potential benefits and practical considerations on modalities of interventions targeting anaplerosis in heart disease, including heart failure.

  3. Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition

    Science.gov (United States)

    Jeong, Seung Min; Hwang, Sunsook; Park, Kyungsoo; Yang, Seungyeon; Seong, Rho Hyun

    2016-01-01

    Cancer cells use precursors derived from tricarboxylic acid (TCA) cycle to support their unlimited growth. However, continuous export of TCA cycle intermediates results in the defect of mitochondrial integrity. Mitochondria glutamine metabolism plays an essential role for the maintenance of mitochondrial functions and its biosynthetic roles by refilling the mitochondrial carbon pool. Here we report that human pancreatic ductal adenocarcinoma (PDAC) cells have a distinct dependence on mitochondrial glutamine metabolism. Whereas glutamine flux into mitochondria contributes to proliferation of most cancer cells, enhanced glutamine anaplerosis results in a pronounced suppression of PDAC growth. A cell membrane permeable α-ketoglutarate analog or overexpression of glutamate dehydrogenase lead to decreased proliferation and increased apoptotic cell death in PDAC cells but not other cancer cells. We found that enhanced glutamine anaplerosis inhibits autophagy, required for tumorigenic growth of PDAC, by activating mammalian TORC1. Together, our results reveal that glutamine anaplerosis is a crucial regulator of growth and survival of PDAC cells, which may provide novel therapeutic approaches to treat these cancers. PMID:27477484

  4. Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition.

    Science.gov (United States)

    Jeong, Seung Min; Hwang, Sunsook; Park, Kyungsoo; Yang, Seungyeon; Seong, Rho Hyun

    2016-01-01

    Cancer cells use precursors derived from tricarboxylic acid (TCA) cycle to support their unlimited growth. However, continuous export of TCA cycle intermediates results in the defect of mitochondrial integrity. Mitochondria glutamine metabolism plays an essential role for the maintenance of mitochondrial functions and its biosynthetic roles by refilling the mitochondrial carbon pool. Here we report that human pancreatic ductal adenocarcinoma (PDAC) cells have a distinct dependence on mitochondrial glutamine metabolism. Whereas glutamine flux into mitochondria contributes to proliferation of most cancer cells, enhanced glutamine anaplerosis results in a pronounced suppression of PDAC growth. A cell membrane permeable α-ketoglutarate analog or overexpression of glutamate dehydrogenase lead to decreased proliferation and increased apoptotic cell death in PDAC cells but not other cancer cells. We found that enhanced glutamine anaplerosis inhibits autophagy, required for tumorigenic growth of PDAC, by activating mammalian TORC1. Together, our results reveal that glutamine anaplerosis is a crucial regulator of growth and survival of PDAC cells, which may provide novel therapeutic approaches to treat these cancers. PMID:27477484

  5. Propionate induces the bovine cytosolic phosphoenolpyruvate carboxykinase promoter activity.

    Science.gov (United States)

    Zhang, Qian; Koser, Stephanie L; Donkin, Shawn S

    2016-08-01

    Cytosolic phosphoenolpyruvate carboxykinase (PCK1) is a critical enzyme within the metabolic networks for gluconeogenesis, hepatic energy metabolism, and tricarboxylic acid cycle function, and is controlled by several transcription factors including hepatic nuclear factor 4α (HNF4α). The primary objective of the present study was to determine whether propionate regulates bovine PCK1 transcription. The second objective was to determine the action of cyclic AMP (cAMP), glucocorticoids, and insulin, hormonal cues known to modulate glucose metabolism, on bovine PCK1 transcriptional activity. The proximal promoter of the bovine PCK1 gene was ligated to a Firefly luciferase reporter and transfected into H4IIE hepatoma cells. Cells were exposed to treatments for 23 h and luciferase activity was determined in cell lysates. Activity of the PCK1 promoter was linearly induced by propionate, and maximally increased 7-fold with 2.5 mM propionate, which was not muted by 100 nM insulin. Activity of the PCK1 promoter was increased 1-fold by either 1.0 mM cAMP or 5.0µM dexamethasone, and 2.2-fold by their combination. Induction by cAMP and dexamethasone was repressed 50% by 100 nM insulin. Propionate, cAMP, and dexamethasone acted synergistically to induce the PCK1 promoter activity. Propionate-responsive regions, identified by 5' deletion analysis, were located between -1,238 and -409 bp and between -85 and +221 bp. Deletions of the core sequences of the 2 putative HNF4α sites decreased the responsiveness to propionate by approximately 40%. These data indicate that propionate regulates its own metabolism through transcriptional stimulation of the bovine PCK1 gene. This induction is mediated, in part, by the 2 putative HNF4α binding sites in the bovine PCK1 promoter. PMID:27289145

  6. Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene.

    OpenAIRE

    Imai, E; Stromstedt, P E; Quinn, P G; Carlstedt-Duke, J; Gustafsson, J.A.; Granner, D K

    1990-01-01

    The minimal DNA sequence required for glucocorticoid induction of the phosphoenolpyruvate carboxykinase (PEPCK) gene in H4IIE rat hepatoma cells was defined. This novel glucocorticoid response unit (GRU) spans about 110 base pairs (bp) and includes two receptor-binding elements plus two accessory factor-binding elements. Purified glucocorticoid receptor bound to two regions (GR1 and GR2) between -395 and -349 bp relative to the transcription start site. Factors in crude rat liver nuclear extr...

  7. Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine

    Science.gov (United States)

    Cetinbas, Naniye Mallı; Sudderth, Jessica; Harris, Robert C.; Cebeci, Aysun; Negri, Gian L.; Yılmaz, Ömer H.; Deberardinis, Ralph J.; Sorensen, Poul H.

    2016-09-01

    Cancer cells have altered metabolism compared to normal cells, including dependence on glutamine (GLN) for survival, known as GLN addiction. However, some cancer cell lines do not require GLN for survival and the basis for this discrepancy is not well understood. GLN is a precursor for antioxidants such as glutathione (GSH) and NADPH, and GLN deprivation is therefore predicted to deplete antioxidants and increase reactive oxygen species (ROS). Using diverse human cancer cell lines we show that this occurs only in cells that rely on GLN for survival. Thus, the preference for GLN as a dominant antioxidant source defines GLN addiction. We show that despite increased glucose uptake, GLN addicted cells do not metabolize glucose via the TCA cycle when GLN is depleted, as revealed by 13C-glucose labeling. In contrast, GLN independent cells can compensate by diverting glucose-derived pyruvate into the TCA cycle. GLN addicted cells exhibit reduced PDH activity, increased PDK1 expression, and PDK inhibition partially rescues GLN starvation-induced ROS and cell death. Finally, we show that combining GLN starvation with pro-oxidants selectively kills GLN addicted cells. These data highlight a major role for GLN in maintaining redox balance in cancer cells that lack glucose-dependent anaplerosis.

  8. Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors

    Science.gov (United States)

    Hidalgo, Jorge; Latorre, Pedro; Carrodeguas, José Alberto; Velázquez-Campoy, Adrián; Sancho, Javier; López-Buesa, Pascual

    2016-01-01

    There exist two isoforms of cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in pig populations that differ in a single amino acid (Met139Leu). The isoenzymes have different kinetic properties, affecting more strongly the Km and Vmax of nucleotides. They are associated to different phenotypes modifying traits of considerable economic interest. In this work we use inhibitors of phosphoenolpyruvate carboxykinase activity to search for further differences between these isoenzymes. On the one hand we have used the well-known inhibitor 3-mercaptopicolinic acid. Its inhibition patterns were the same for both isoenzymes: a three-fold decrease of the Ki values for GTP in 139Met and 139Leu (273 and 873 μM, respectively). On the other hand, through screening of a chemical library we have found two novel compounds with inhibitory effects of a similar magnitude to that of 3-mercaptopicolinic acid but with less solubility and specificity. One of these novel compounds, (N'1-({5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-thienyl}methylidene)-2,4-dichlorobenzene-1-carbohydrazide), exhibited significantly different inhibitory effects on either isoenzyme: it enhanced threefold the apparent Km value for GTP in 139Met, whereas in 139Leu, it reduced it from 99 to 69 μM. The finding of those significant differences in the binding of GTP reinforces the hypothesis that the Met139Leu substitution affects strongly the nucleotide binding site of PEPCK-C. PMID:27391465

  9. Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus

    Energy Technology Data Exchange (ETDEWEB)

    Ludwig, D.S. [Beth Israel Hospital, Boston, MA (United States)]|[Children`s Hospital, Boston, MA (United States); Vidal-Puig, A.; Moller, D.E. [Beth Israel Hospital, Boston, MA (United States)] [and others

    1996-02-01

    Expression of phosphoenolpyruvate carboxykinase (PEPCK), a rate-limiting enzyme in gluconeogenesis, is under dominant negative regulation by insulin. In this study, we sought to test the hypothesis that mutations in the PEPCK gene promoter may impair the ability of insulin to suppress hepatic glucose production, thereby contributing to both the insulin resistance and increased rate of gluconeogenesis characteristic of NIDDM. The proximal PEPCK promoter region in 117 patients with noninsulin-dependent diabetes mellitus and 20 obese Pima Indians was amplified by PCR and analyzed with single strand conformation of polymorphism techniques. In addition, limited direct DNA sequencing was performed on the insulin response sequence and flanking regions. No DNA sequence polymorphisms were found in any patient. This result suggests that mutations in cis-acting PEPCK gene regulatory elements do not constitute a common cause of noninsulin-dependent diabetes mellitus. The significance of genetic variation in promoter regions to human disease is discussed. 40 refs., 1 figs., 1 tab.

  10. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Cline, Gary W., E-mail: gary.cline@yale.edu [The Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 (United States); Department of Surgery, University of Minnesota-Twin Cities, Minneapolis, MN 55455 (United States); Pongratz, Rebecca L.; Zhao, Xiaojian [The Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 (United States); Papas, Klearchos K. [Department of Surgery, University of Minnesota-Twin Cities, Minneapolis, MN 55455 (United States)

    2011-11-11

    Highlights: Black-Right-Pointing-Pointer We studied media effects on mechanisms of insulin secretion of INS-1 cells. Black-Right-Pointing-Pointer Insulin secretion was higher in DMEM than KRB despite identical ATP synthesis rates. Black-Right-Pointing-Pointer Insulin secretion rates correlated with rates of anaplerosis and TCA cycle. Black-Right-Pointing-Pointer Mitochondria metabolism and substrate cycles augment secretion signal of ATP. -- Abstract: Mechanistic models of glucose stimulated insulin secretion (GSIS) established in minimal media in vitro, may not accurately describe the complexity of coupling metabolism with insulin secretion that occurs in vivo. As a first approximation, we have evaluated metabolic pathways in a typical growth media, DMEM as a surrogate in vivo medium, for comparison to metabolic fluxes observed under the typical experimental conditions using the simple salt-buffer of KRB. Changes in metabolism in response to glucose and amino acids and coupling to insulin secretion were measured in INS-1 832/13 cells. Media effects on mitochondrial function and the coupling efficiency of oxidative phosphorylation were determined by fluorometrically measured oxygen consumption rates (OCRs) combined with {sup 31}P NMR measured rates of ATP synthesis. Substrate preferences and pathways into the TCA cycle, and the synthesis of mitochondrial 2nd messengers by anaplerosis were determined by {sup 13}C NMR isotopomer analysis of the fate of [U-{sup 13}C] glucose metabolism. Despite similar incremental increases in insulin secretion, the changes of OCR in response to increasing glucose from 2.5 to 15 mM were blunted in DMEM relative to KRB. Basal and stimulated rates of insulin secretion rates were consistently higher in DMEM, while ATP synthesis rates were identical in both DMEM and KRB, suggesting greater mitochondrial uncoupling in DMEM. The relative rates of anaplerosis, and hence synthesis and export of 2nd messengers from the mitochondria were found

  11. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb’s cycle flux independent of ATP synthesis

    International Nuclear Information System (INIS)

    Highlights: ► We studied media effects on mechanisms of insulin secretion of INS-1 cells. ► Insulin secretion was higher in DMEM than KRB despite identical ATP synthesis rates. ► Insulin secretion rates correlated with rates of anaplerosis and TCA cycle. ► Mitochondria metabolism and substrate cycles augment secretion signal of ATP. -- Abstract: Mechanistic models of glucose stimulated insulin secretion (GSIS) established in minimal media in vitro, may not accurately describe the complexity of coupling metabolism with insulin secretion that occurs in vivo. As a first approximation, we have evaluated metabolic pathways in a typical growth media, DMEM as a surrogate in vivo medium, for comparison to metabolic fluxes observed under the typical experimental conditions using the simple salt-buffer of KRB. Changes in metabolism in response to glucose and amino acids and coupling to insulin secretion were measured in INS-1 832/13 cells. Media effects on mitochondrial function and the coupling efficiency of oxidative phosphorylation were determined by fluorometrically measured oxygen consumption rates (OCRs) combined with 31P NMR measured rates of ATP synthesis. Substrate preferences and pathways into the TCA cycle, and the synthesis of mitochondrial 2nd messengers by anaplerosis were determined by 13C NMR isotopomer analysis of the fate of [U-13C] glucose metabolism. Despite similar incremental increases in insulin secretion, the changes of OCR in response to increasing glucose from 2.5 to 15 mM were blunted in DMEM relative to KRB. Basal and stimulated rates of insulin secretion rates were consistently higher in DMEM, while ATP synthesis rates were identical in both DMEM and KRB, suggesting greater mitochondrial uncoupling in DMEM. The relative rates of anaplerosis, and hence synthesis and export of 2nd messengers from the mitochondria were found to be similar in DMEM to those in KRB. And, the correlation of total PC flux with insulin secretion rates in DMEM was

  12. Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.

    Science.gov (United States)

    Santra, Saikat; Cameron, Jessie M; Shyr, Casper; Zhang, Linhua; Drögemöller, Britt; Ross, Colin J; Wasserman, Wyeth W; Wevers, Ron A; Rodenburg, Richard J; Gupte, Girish; Preece, Mary Anne; van Karnebeek, Clara D

    2016-05-01

    We report a patient from a consanguineous family who presented with transient acute liver failure and biochemical patterns suggestive of disturbed urea cycle and mitochondrial function, for whom conventional genetic and metabolic investigations for acute liver failure failed to yield a diagnosis. Whole exome sequencing revealed a homozygous 12-bp deletion in PCK1 (MIM 614168) encoding cytosolic phosphoenolpyruvate carboxykinase (PEPCK); enzymatic studies subsequently confirmed its pathogenic nature. We propose that PEPCK deficiency should be considered in the young child with unexplained liver failure, especially where there are marked, accumulations of TCA cycle metabolites on urine organic acid analysis and/or an amino acid profile with hyperammonaemia suggestive of a proximal urea cycle defect during the acute episode. If suspected, intravenous administration of dextrose should be initiated. Long-term management comprising avoidance of fasting with the provision of a glucose polymer emergency regimen for illness management may be sufficient to prevent future episodes of liver failure. This case report provides further insights into the (patho-)physiology of energy metabolism, confirming the power of genomic analysis of unexplained biochemical phenotypes. PMID:26971250

  13. Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus.

    Science.gov (United States)

    Wu, J; Hou, S S; Wang, W; Yin, M; Cheng, N; Ge, L L; Yin, J J; Xu, J

    2015-01-01

    The objective of this study was to investigate the mRNA expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM). Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into the GBS, sham operation with diet restriction (SO), and sham operation alone (control) groups (N = 12 per group). Liver specimens from all rats were obtained during the operation and 8 weeks after operation. Blood lipid levels were measured before and 8 weeks after operation. Fasting blood glucose (FBG), food intake, and body weight were recorded at weekly time points after operation. The blood glucose area under the curve (AUC) was calculated, and insulin sensitivity indices (ISI) were assessed. The expression PEPCK mRNA and protein were measured by real-time polymerase chain reaction and western blot. Compared with those of the SO and control groups, the blood lipid levels and the FBG in the GBS group was significantly decreased (P rats while improving glucose tolerance and hyperglycemia, and the mechanism appears to be associated with a decrease of hepatic PEPCK mRNA and protein expression. PMID:26681041

  14. An assessment of the capacity for phosphoenolpyruvate carboxykinase to contribute to C4 photosynthesis.

    Science.gov (United States)

    Koteyeva, Nuria K; Voznesenskaya, Elena V; Edwards, Gerald E

    2015-06-01

    Three C4 acid decarboxylases, phosphoenolpyruvate carboxykinase (PEPCK), NADP-malic enzyme (NADP-ME), and NAD-malic enzyme (NAD-ME) were recruited from C3 plants to support C4 photosynthesis. In Poaceae, there are established lineages having PEPCK type species, and some NADP-ME lineages in which PEPCK contributes to C4. Besides family Poaceae, recently PEPCK has been reported to function in C4 photosynthesis in eudicot species including Cleome gynandra (Cleomaceae), Trianthema portulacastrum and Zaleya pentandra (Aizoaceae). We evaluated PEPCK by enzyme assay and western blots in representatives of Poaceae, Aizoaceae, Cleomaceae, and Chenopodiaceae compared to that in the PEPCK type C4 grass Spartina anglica. Eragrostis nutans was identified as the first NAD-ME type C4 grass having substantial amounts of PEPCK. In the eudicots, including C. gynandra, Cleome angustifolia, T. portulacastrum, Z. pentandra, and nine C4 members of family Chenopodiaceae (which has the most C4 species and diversity in forms among eudicot families), amounts of PEPCK were generally very low (barely detectable up to 4% of that in S. anglica). Based on these results, C4 species can be classified biochemically according to the dominant decarboxylase recruited for C4 function; and, Poaceae remains the only family in which PEPCK is known to have a significant role in C4 photosynthesis.

  15. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis.

    Science.gov (United States)

    Cline, Gary W; Pongratz, Rebecca L; Zhao, Xiaojian; Papas, Klearchos K

    2011-11-11

    Mechanistic models of glucose stimulated insulin secretion (GSIS) established in minimal media in vitro, may not accurately describe the complexity of coupling metabolism with insulin secretion that occurs in vivo. As a first approximation, we have evaluated metabolic pathways in a typical growth media, DMEM as a surrogate in vivo medium, for comparison to metabolic fluxes observed under the typical experimental conditions using the simple salt-buffer of KRB. Changes in metabolism in response to glucose and amino acids and coupling to insulin secretion were measured in INS-1 832/13 cells. Media effects on mitochondrial function and the coupling efficiency of oxidative phosphorylation were determined by fluorometrically measured oxygen consumption rates (OCRs) combined with (31)P NMR measured rates of ATP synthesis. Substrate preferences and pathways into the TCA cycle, and the synthesis of mitochondrial 2nd messengers by anaplerosis were determined by (13)C NMR isotopomer analysis of the fate of [U-(13)C] glucose metabolism. Despite similar incremental increases in insulin secretion, the changes of OCR in response to increasing glucose from 2.5 to 15mM were blunted in DMEM relative to KRB. Basal and stimulated rates of insulin secretion rates were consistently higher in DMEM, while ATP synthesis rates were identical in both DMEM and KRB, suggesting greater mitochondrial uncoupling in DMEM. The relative rates of anaplerosis, and hence synthesis and export of 2nd messengers from the mitochondria were found to be similar in DMEM to those in KRB. And, the correlation of total PC flux with insulin secretion rates in DMEM was found to be congruous with the correlation in KRB. Together, these results suggest that signaling mechanisms associated with both TCA cycle flux and with anaplerotic flux, but not ATP production, may be responsible for the enhanced rates of insulin secretion in more complex, and physiologically-relevant media. PMID:22008547

  16. Phosphoenolpyruvate carboxykinase in bovine tick Rhipicephalus (Boophilus) micro plus embryogenesis and starvation larvae

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, J.G. de; Mentizingen, L.G.; Logullo, C. [Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, RJ (Brazil). Centro de Biociencias e Biotecnologia. Lab.de Quimica e Funcao de Proteinas e Peptideos (LQFPP); Andrade, C.P. de; Vaz Junior, Itabajara [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Centro de Biotecnologia; Daffre, S.; Esteves, E. [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Ciencias Biomedicas

    2008-07-01

    Full text: Phosphoenolpyruvate carboxykinase (PEPCK) is considered a key rate controlling enzyme in gluconeogenesis pathway. Gluconeogenesis is a highly regulated process, catalyzed by several enzymes subject to regulation by insulin. Normally, insulin rapidly and substantially inhibits PEPCK gene transcription and the PEPCK activity is proportional to the rate of gene transcription. The transcriptional regulation of the PEPCK gene has been extensively studied. CREM is the transcription factor that bind efficiently to the putative cyclic AMP response element (CRE) in PEPCK gene. Several other transcription factors can bind to this element and activate transcription. In oviparous animals, such as bovine tick R. microplus, the embryonic development occurs outside the maternal organism, implying that all the nutrients necessary for embryogenesis must be present in the oocytes. We observed the relationship between the main energy sources and the morphogenetic changes that occur during R. microplus tick embryogenesis. Energy homeostasis is maintained by glycogen mobilization in the beginning of embryogenesis, as its content is drastically decreased during the first five days of development. Afterwards, the activity of the gluconeogenesis enzyme PEPCK increases enormously, as indicated by a concomitant increase in glucose content (Moraes et al., 2007). Here, we analyzed PEPCK gene transcription by qPCR during the embryogenesis and starvation larvae. The PEPCK transcription was higher at first and 15th day eggs of the development. In larvae the levels of PEPCK transcripts is increased at fifth day after hatch. However, the activity is continuous increased in larvae the form first up to 15th day. Now we are investigating the involvement of CREM in the PEPCK gene transcription in these cells. In this sense, we obtained CREM sequence from TIGR ESTs R. microplus bank and designed the specific primers to qPCR. Taken together our results suggest the involvement of PEPCK to the

  17. Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism

    Directory of Open Access Journals (Sweden)

    Kalhan Satish C

    2005-11-01

    Full Text Available Abstract Background The metabolic function of PEPCK-C is not fully understood; deletion of the gene for the enzyme in mice provides an opportunity to fully assess its function. Methods The gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP (EC 4.1.1.32 (PEPCK-C was deleted in mice by homologous recombination (PEPCK-C-/- mice and the metabolic consequences assessed. Results PEPCK-C-/- mice became severely hypoglycemic by day two after birth and then died with profound hypoglycemia (12 mg/dl. The mice had milk in their stomachs at day two after birth and the administration of glucose raised the concentration of blood glucose in the mice but did not result in an increased survival. PEPCK-C-/- mice have two to three times the hepatic triglyceride content as control littermates on the second day after birth. These mice also had an elevation of lactate (2.5 times, β-hydroxybutyrate (3 times and triglyceride (50% in their blood, as compared to control animals. On day two after birth, alanine, glycine, glutamine, glutamate, aspartate and asparagine were elevated in the blood of the PEPCK-C-/- mice and the blood urea nitrogen concentration was increased by 2-fold. The rate of oxidation of [2-14C]-acetate, and [5-14C]-glutamate to 14CO2 by liver slices from PEPCK-C-/- mice at two days of age was greatly reduced, as was the rate of fatty acid synthesis from acetate and glucose. As predicted by the lack of PEPCK-C, the concentration of malate in the livers of the PEPCK-C-/- mice was 10 times that of controls. Conclusion We conclude that PEPCK-C is required not only for gluconeogenesis and glyceroneogenesis but also for cataplerosis (i.e. the removal of citric acid cycle anions and that the failure of this process in the livers of PEPCK-C-/- mice results in a marked reduction in citric acid cycle flux and the shunting of hepatic lipid into triglyceride, resulting in a fatty liver.

  18. Hepatic Subcellular Compartmentation of Cytoplasmic Phosphoenolpyruvate Carboxykinase Determined by Immunogold Electron Microscopy

    Science.gov (United States)

    Gao, Kuixiong; Cardell, Emma Lou; Morris, Randal E.; Giffin, Bruce F.; Cardell, Robert R.

    1995-08-01

    Phosphoenolpyruvate carboxykinase (PEPCK) is the rate-limiting gluconeogenic enzyme and in liver occurs in a lobular gradient from periportal to pericentral regions. The subcellular distribution of cytoplasmic PEPCK molecules within hepatocytes and its relationship to organelles have not been determined previously. In this study, we have used immunogold electron microscopy to evaluate the subcellar distribution of the enzyme, in addition to brightfield and epipolarized light microscopy. Cryosections (10 [mu]m) of perfusion-fixed rat liver were collected on silanated slides and immunostained using goat anti-rat PEPCK followed by 5-nm gold-labeled secondary and tertiary antibodies. Additionally, free-floating vibratome sections (25, 50, and 100 [mu]m) of perfusion-immersion-fixed rat liver were immunogold stained using goat anti-rat PEPCK and 5-nm gold-labeled secondary antibody, with and without silver enhancement. The immunogold labeled sections from both procedures were embedded in epoxy resin for the preparation of thin sections for electron microscopy. The results showed that the gold-labeled antibodies penetrated the entire thickness of cryosections, resulting in a high signal for PEPCK, but membranes in general, the smooth endoplasmic reticulum in particular, were not identifiable as electron dense unit membranes. On the other hand, the vibratome sections of well-fixed tissue allowed good visualization of the ultrastructure of cellular organelles, with the smooth endoplasmic reticulum appearing as vesicles and tubules with electron dense unit membranes; however, the penetration of the gold-labeled antibody was limited to cells at the surface of the vibratome sections. In both procedures, PEPCK, as indicated by gold particles, is predominantly in the glycogen areas of the cytosome and not in mitochondria, nuclei, Golgi apparatus, or other cell organelles. Hepatocytes in periportal regions have a compact subcellular distribution of PEPCK shown by gold particles

  19. Compartmentation of Metabolism of the C12-, C9-, and C5-n-dicarboxylates in Rat Liver, Investigated by Mass Isotopomer Analysis: ANAPLEROSIS FROM DODECANEDIOATE.

    Science.gov (United States)

    Jin, Zhicheng; Bian, Fang; Tomcik, Kristyen; Kelleher, Joanne K; Zhang, Guo-Fang; Brunengraber, Henri

    2015-07-24

    We investigated the compartmentation of the catabolism of dodecanedioate (DODA), azelate, and glutarate in perfused rat livers, using a combination of metabolomics and mass isotopomer analyses. Livers were perfused with recirculating or nonrecirculating buffer containing one fully (13)C-labeled dicarboxylate. Information on the peroxisomal versus mitochondrial catabolism was gathered from the labeling patterns of acetyl-CoA proxies, i.e. total acetyl-CoA, the acetyl moiety of citrate, C-1 + 2 of β-hydroxybutyrate, malonyl-CoA, and acetylcarnitine. Additional information was obtained from the labeling patterns of citric acid cycle intermediates and related compounds. The data characterize the partial oxidation of DODA and azelate in peroxisomes, with terminal oxidation in mitochondria. We did not find evidence of peroxisomal oxidation of glutarate. Unexpectedly, DODA contributes a substantial fraction to anaplerosis of the citric acid cycle. This opens the possibility to use water-soluble DODA in nutritional or pharmacological anaplerotic therapy when other anaplerotic substrates are impractical or contraindicated, e.g. in propionic acidemia and methylmalonic acidemia.

  20. The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids.

    OpenAIRE

    Hall, R K; Sladek, F M; Granner, D K

    1995-01-01

    Glucocorticoids stimulate hepatic phosphoenolpyruvate carboxykinase (PEPCK; EC 4.1.1.32) gene expression, thereby increasing the rate of gluconeogenesis. The effect of glucocorticoids on PEPCK gene expression is mediated by a set of promoter elements collectively referred to as the glucocorticoid response unit. The response unit spans a 100-bp segment and includes two glucocorticoid receptor binding sites (GR1 and GR2) and two accessory factor binding sites (AF1 and AF2), all of which are req...

  1. Phosphoenolpyruvate carboxykinase (PEPCK) deficiency affects the germination, growth and fruit sugar content in tomato (Solanum lycopersicum L.).

    Science.gov (United States)

    Huang, Yong-Xing; Yin, Yong-Gen; Sanuki, Atsuko; Fukuda, Naoya; Ezura, Hiroshi; Matsukura, Chiaki

    2015-11-01

    Phosphoenolpyruvate carboxykinase (PEPCK) is a key regulatory enzyme and is utilized in the gluconeogenesis pathway in plants. Although, its catalytic and regulatory properties are quite well understood, there are uncertainties regarding its physiological role in many plants tissues such as the flesh of developing fruits. To further understand the function of PEPCK in fruits and other tissues, RNAi transgenic tomato plants in which SlPEPCK transcription was down-regulated by either CaMV 35S constitutive promoter or the fruit-specific E8 promoter were generated and characterized on the basis of their phenotypic and metabolic aspects. In the PEPCK-deficient lines, prominent growth suppression of germinated seedlings was observed and other vegetative suppression appeared during the early stage of plant growth in the 35S promoter-driven lines. In particular, root elongation was most obviously suppressed in the germinated seedlings, indicating that the gluconeogenesis pathway is involved in the root growth of seedlings. Regarding the primary metabolism in fruit, the soluble sugar content tended to decrease, whereas the malate content tended to increase in ripening fruits of the RNAi lines compared with the wild type. These results indicate that activation of the gluconeogenesis pathway from organic acids to sugars occurs during ripening but is suppressed by the knocking down of the PEPCK gene, suggesting that PEPCK participates in determining the sugar/acid ratio in ripening fruit.

  2. Phosphoenolpyruvate carboxykinase (PEPCK) deficiency affects the germination, growth and fruit sugar content in tomato (Solanum lycopersicum L.).

    Science.gov (United States)

    Huang, Yong-Xing; Yin, Yong-Gen; Sanuki, Atsuko; Fukuda, Naoya; Ezura, Hiroshi; Matsukura, Chiaki

    2015-11-01

    Phosphoenolpyruvate carboxykinase (PEPCK) is a key regulatory enzyme and is utilized in the gluconeogenesis pathway in plants. Although, its catalytic and regulatory properties are quite well understood, there are uncertainties regarding its physiological role in many plants tissues such as the flesh of developing fruits. To further understand the function of PEPCK in fruits and other tissues, RNAi transgenic tomato plants in which SlPEPCK transcription was down-regulated by either CaMV 35S constitutive promoter or the fruit-specific E8 promoter were generated and characterized on the basis of their phenotypic and metabolic aspects. In the PEPCK-deficient lines, prominent growth suppression of germinated seedlings was observed and other vegetative suppression appeared during the early stage of plant growth in the 35S promoter-driven lines. In particular, root elongation was most obviously suppressed in the germinated seedlings, indicating that the gluconeogenesis pathway is involved in the root growth of seedlings. Regarding the primary metabolism in fruit, the soluble sugar content tended to decrease, whereas the malate content tended to increase in ripening fruits of the RNAi lines compared with the wild type. These results indicate that activation of the gluconeogenesis pathway from organic acids to sugars occurs during ripening but is suppressed by the knocking down of the PEPCK gene, suggesting that PEPCK participates in determining the sugar/acid ratio in ripening fruit. PMID:26381194

  3. Cloning and expression of phosphoenolpyruvate carboxykinase from a cestode parasite and its solubilization from inclusion bodies using l-arginine.

    Science.gov (United States)

    Dutta, Asim K; Ramnath; Dkhar, Barilin; Tandon, Veena; Das, Bidyadhar

    2016-09-01

    Phosphoenolpyruvate carboxykinase is an essential regulatory enzyme of glycolysis in the cestode parasite, Raillietina echinobothrida, and is considered a potential target for anthelmintic action because of its differential activity from that of its avian host. However, due to the unavailability of its structure, the mechanism of regulation of PEPCK from R. echinobothrida (rePEPCK) and its interaction with possible modulators remain unclear. Hence, in this study, the rePEPCK gene was cloned into pGEX-4T-3 and overexpressed for its characterization. On being induced by IPTG, the recombinant rePEPCK was expressed as inclusion bodies (IBs); hence, various agents, like different inducer concentrations, temperature, time, host cell types, culture media, pH, and additives, were used to bring the protein to soluble form. Finally, a significant amount (∼46%) of rePEPCK was solubilized from IBs by adding 2M l-arginine. Near-UV circular dichroism spectra analysis indicated that l-arginine (2M) had no effect on the conformation of the protein. In this study, we have reported a yield of ∼73mg of purified rePEPCK per 1L of culture. The purified rePEPCK retained its biological activity, and Km of the enzyme for its substrate was determined and discussed. The availability of recombinant rePEPCK may help in biochemical- and biophysical-studies to explore its molecular mechanisms and regulations.

  4. Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans.

    Science.gov (United States)

    Yuan, Yiyuan; Hakimi, Parvin; Kao, Clara; Kao, Allison; Liu, Ruifu; Janocha, Allison; Boyd-Tressler, Andrea; Hang, Xi; Alhoraibi, Hanna; Slater, Erin; Xia, Kevin; Cao, Pengxiu; Shue, Quinn; Ching, Tsui-Ting; Hsu, Ao-Lin; Erzurum, Serpil C; Dubyak, George R; Berger, Nathan A; Hanson, Richard W; Feng, Zhaoyang

    2016-01-15

    Aging involves progressive loss of cellular function and integrity, presumably caused by accumulated stochastic damage to cells. Alterations in energy metabolism contribute to aging, but how energy metabolism changes with age, how these changes affect aging, and whether they can be modified to modulate aging remain unclear. In locomotory muscle of post-fertile Caenorhabditis elegans, we identified a progressive decrease in cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), a longevity-associated metabolic enzyme, and a reciprocal increase in glycolytic pyruvate kinase (PK) that were necessary and sufficient to limit lifespan. Decline in PEPCK-C with age also led to loss of cellular function and integrity including muscle activity, and cellular senescence. Genetic and pharmacologic interventions of PEPCK-C, muscle activity, and AMPK signaling demonstrate that declines in PEPCK-C and muscle function with age interacted to limit reproductive life and lifespan via disrupted energy homeostasis. Quantifications of metabolic flux show that reciprocal changes in PEPCK-C and PK with age shunted energy metabolism toward glycolysis, reducing mitochondrial bioenergetics. Last, calorie restriction countered changes in PEPCK-C and PK with age to elicit anti-aging effects via TOR inhibition. Thus, a programmed metabolic event involving PEPCK-C and PK is a determinant of aging that can be modified to modulate aging.

  5. Cloning and expression of phosphoenolpyruvate carboxykinase from a cestode parasite and its solubilization from inclusion bodies using l-arginine.

    Science.gov (United States)

    Dutta, Asim K; Ramnath; Dkhar, Barilin; Tandon, Veena; Das, Bidyadhar

    2016-09-01

    Phosphoenolpyruvate carboxykinase is an essential regulatory enzyme of glycolysis in the cestode parasite, Raillietina echinobothrida, and is considered a potential target for anthelmintic action because of its differential activity from that of its avian host. However, due to the unavailability of its structure, the mechanism of regulation of PEPCK from R. echinobothrida (rePEPCK) and its interaction with possible modulators remain unclear. Hence, in this study, the rePEPCK gene was cloned into pGEX-4T-3 and overexpressed for its characterization. On being induced by IPTG, the recombinant rePEPCK was expressed as inclusion bodies (IBs); hence, various agents, like different inducer concentrations, temperature, time, host cell types, culture media, pH, and additives, were used to bring the protein to soluble form. Finally, a significant amount (∼46%) of rePEPCK was solubilized from IBs by adding 2M l-arginine. Near-UV circular dichroism spectra analysis indicated that l-arginine (2M) had no effect on the conformation of the protein. In this study, we have reported a yield of ∼73mg of purified rePEPCK per 1L of culture. The purified rePEPCK retained its biological activity, and Km of the enzyme for its substrate was determined and discussed. The availability of recombinant rePEPCK may help in biochemical- and biophysical-studies to explore its molecular mechanisms and regulations. PMID:26363119

  6. Phosphoenolpyruvate Carboxykinase, a Key Enzyme That Controls Blood Glucose, Is a Target of Retinoic Acid Receptor-Related Orphan Receptor α.

    Directory of Open Access Journals (Sweden)

    Hiroshi Matsuoka

    Full Text Available Phosphoenolpyruvate carboxykinase (PEPCK catalyzes a committed and rate-limiting step in hepatic gluconeogenesis, and its activity is tightly regulated to maintain blood glucose levels within normal limits. PEPCK activity is primarily regulated through hormonal control of gene transcription. Transcription is additionally regulated via a cAMP response unit, which includes a cAMP response element and four binding sites for CCAAT/enhancer-binding protein (C/EBP. Notably, the cAMP response unit also contains a putative response element for retinoic acid receptor-related orphan receptor α (RORα. In this paper, we characterize the effect of the RORα response element on cAMP-induced transcription. Electrophoresis mobility shift assay indicates that RORα binds this response element in a sequence-specific manner. Furthermore, luciferase reporter assays indicate that RORα interacts with C/EBP at the PEPCK promoter to synergistically enhance transcription. We also found that cAMP-induced transcription depends in part on RORα and its response element. In addition, we show that suppression of RORα by siRNA significantly decreased PEPCK transcription. Finally, we found that a RORα antagonist inhibits hepatic gluconeogenesis in an in vitro glucose production assay. Taken together, the data strongly suggest that PEPCK is a direct RORα target. These results define possible new roles for RORα in hepatic gluconeogenesis.

  7. Effect of 7-Hydroxy-2-(4-Hydroxy-3-Methoxy-Phenyl-Chroman-4-One (Swietenia Macrophylla King Seed on Retinol Binding Protein-4 and Phosphoenolpyruvate Carboxykinase Gene Expression in Type 2 Diabetic Rats

    Directory of Open Access Journals (Sweden)

    Prasetyastuti

    2016-09-01

    Full Text Available Background and Aims: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to a defect of insulin secretion, insulin action, or both. There are increasing evidence that active compounds of medicinal plants may be used to treat diabetes. The aim of this study is to investigate the effect of a 7-hydroxy-2-(4-hydroxy-3-methoxy-phenyl-chroman-4-one flavonoid compound of the Swietenia macrophylla King seed on homeostatic model assessment of insulin resistance (HOMA-IR, phosphoenolpyruvate carboxykinase (PEPCK and retinol binding protein-4 (RBP4 gene expression in diabetic rats.

  8. Phosphoenolpyruvate carboxykinase, pyruvate orthophosphate dikinase and isocitrate lyase in both tomato fruits and leaves, and in the flesh of peach and some other fruits.

    Science.gov (United States)

    Famiani, Franco; Paoletti, Andrea; Battistelli, Alberto; Moscatello, Stefano; Chen, Zhi-Hui; Leegood, Richard C; Walker, Robert P

    2016-09-01

    In this study the occurrence of a number of enzymes involved in gluconeogenesis was investigated in both tomato fruits and leaves during their development and senescence and in some other fruits. The enzymes studied were phosphoenolpyruvate carboxykinase (PEPCK), pyruvate orthophosphate dikinase (PPDK) and glyoxysomal isocitrate lyase (ICL). PPDK was detected in the ripe flesh of tomato, and much smaller amounts were detected in the flesh of both peach and pepper, whereas it was not detected (not present or at very low abundance) in the other fruits which were investigated (apricot, aubergine, blackberry, blueberry, cherry, grape, plum, raspberry and red current). By contrast PEPCK was present in the flesh of all the fruits investigated. Very small amounts of ICL were detected in ripe tomato flesh. PEPCK was present in the skin, flesh, locular gel and columella of tomato fruit, and in these its abundance increased greatly during ripening. PPDK showed a similar distribution, however, its abundance did not increase during ripening. PEPCK was not detected in tomato leaves at any stage of their development or senescence. The content of PPDK g(-1) fresh weight (FW) increased in tomato leaves as they matured, however, it declined during their senescence. In tomato leaves the content of ICL g(-1) FW increased until the mid-stage of development, then decreased as the leaf matured, and then increased during the latter stages of senescence. In the flesh of tomato fruits the contents of PPDK and PEPCK g(-1) FW decreased during senescence. The results suggest that in fruits other than tomato the bulk of any gluconeogenic flux proceeds via PEPCK, whereas in tomato both PEPCK and PPDK could potentially be utilised. Further, the results indicate that the conversion of pyruvate/acetyl-CoA to malate by the glyoxylate cycle, for which ICL is necessary, is not a major pathway utilised by gluconeogenesis in fruits under normal conditions of growth. Finally, the results contribute to

  9. The link in Linking

    Science.gov (United States)

    Caldwell, Jane C; Chiale, Pablo A; Gonzalez, Mario D; Baranchuk, Adrian

    2013-01-01

    We present 2 cases of the slow-fast form of AVNRT with initially narrow QRS complexes followed by sudden unexpected transition to persistently wide QRS complexes due to aberrant intraventricular conduction. Introduction of a properly timed extrastimulus in one case and critical oscillations in cycle length due to short-long coupling in the second case set the stage for the initial bundle branch block. However, persistence of the aberrancy pattern once the initial event abated was maintained by the "linking" phenomenon. Delayed, retrograde concealed activation from the contralateral bundle branch perpetuated the initial bundle branch block. PMID:23840106

  10. Linked Lives

    NARCIS (Netherlands)

    Djundeva, Maja; Wright, James D.

    2015-01-01

    This article refers to the Linked Lives, following the development of the life course theory during the 1980s and the 1990s and the seminal works of Elder and colleagues. In the first part the concepts linked to Linked Lives: timing, living in time and place, human agency are described in detail wit

  11. Role of the tumor suppressor IQGAP2 in metabolic homeostasis: Possible link between diabetes and cancer.

    Science.gov (United States)

    Vaitheesvaran, B; Hartil, K; Navare, A; Zheng; OBroin, P; Golden, A; Guha; Lee, Wn; Kurland, I J; Bruce, J E

    2014-10-01

    Deficiency of IQGAP2, a scaffolding protein expressed primarily in liver leads to rearrangements of hepatic protein compartmentalization and altered regulation of enzyme functions predisposing development of hepatocellular carcinoma and diabetes. Employing a systems approach with proteomics, metabolomics and fluxes characterizations, we examined the effects of IQGAP2 deficient proteomic changes on cellular metabolism and the overall metabolic phenotype. Iqgap2(-/-) mice demonstrated metabolic inflexibility, fasting hyperglycemia and obesity. Such phenotypic characteristics were associated with aberrant hepatic regulations of glycolysis/gluconeogenesis, glycogenolysis, lipid homeostasis and futile cycling corroborated with corresponding proteomic changes in cytosolic and mitochondrial compartments. IQGAP2 deficiency also led to truncated TCA-cycle, increased anaplerosis, increased supply of acetyl-CoA for de novo lipogenesis, and increased mitochondrial methyl-donor metabolism necessary for nucleotides synthesis. Our results suggest that changes in metabolic networks in IQGAP2 deficiency create a hepatic environment of a 'pre-diabetic' phenotype and a predisposition to non-alcoholic fatty liver disease (NAFLD) which has been linked to the development of hepatocellular carcinoma. PMID:25254002

  12. Link Analysis

    Science.gov (United States)

    Donoho, Steve

    Link analysis is a collection of techniques that operate on data that can be represented as nodes and links. This chapter surveys a variety of techniques including subgraph matching, finding cliques and K-plexes, maximizing spread of influence, visualization, finding hubs and authorities, and combining with traditional techniques (classification, clustering, etc). It also surveys applications including social network analysis, viral marketing, Internet search, fraud detection, and crime prevention.

  13. Operative Links

    DEFF Research Database (Denmark)

    Wistoft, Karen; Højlund, Holger

    2012-01-01

    educational approaches. Methods: Mixed qualitative design: survey based on telephone interviews with health managers (n=72), personal and focus group interviews with health professionals (n=84) and pupils (n=108) from 18 school classes, and comparative case studies in five selected municipalities of various......, health professionalism, and management strategies pose the foremost challenge. Operational links indicates cooperative levels that facilitate a creative and innovative effort across traditional professional boundaries. It is proposed that such links are supported by network structures, shared semantics...

  14. Dancing links

    CERN Document Server

    Knuth, Donald E

    2009-01-01

    The author presents two tricks to accelerate depth-first search algorithms for a class of combinatorial puzzle problems, such as tiling a tray by a fixed set of polyominoes. The first trick is to implement each assumption of the search with reversible local operations on doubly linked lists. By this trick, every step of the search affects the data incrementally. The second trick is to add a ghost square that represents the identity of each polyomino. Thus puts the rule that each polyomino be used once on the same footing as the rule that each square be covered once. The coding simplifies to a more abstract form which is equivalent to 0-1 integer programming. More significantly for the total computation time, the search can naturally switch between placing a fixed polyomino or covering a fixed square at different stages, according to a combined heuristic. Finally the author reports excellent performance for his algorithm for some familiar puzzles. These include tiling a hexagon by 19 hexiamonds and the N queen...

  15. Sex-linked dominant

    Science.gov (United States)

    Inheritance - sex-linked dominant; Genetics - sex-linked dominant; X-linked dominant; Y-linked dominant ... can be either an autosomal chromosome or a sex chromosome. It also depends on whether the trait ...

  16. Sex-linked dominant

    Science.gov (United States)

    Inheritance - sex-linked dominant; Genetics - sex-linked dominant; X-linked dominant; Y-linked dominant ... type of chromosome that is affected (autosomal or sex chromosome). It also depends on whether the trait ...

  17. Linked data management

    CERN Document Server

    Hose, Katja; Schenkel, Ralf

    2014-01-01

    Linked Data Management presents techniques for querying and managing Linked Data that is available on today’s Web. The book shows how the abundance of Linked Data can serve as fertile ground for research and commercial applications. The text focuses on aspects of managing large-scale collections of Linked Data. It offers a detailed introduction to Linked Data and related standards, including the main principles distinguishing Linked Data from standard database technology. Chapters also describe how to generate links between datasets and explain the overall architecture of data integration systems based on Linked Data. A large part of the text is devoted to query processing in different setups. After presenting methods to publish relational data as Linked Data and efficient centralized processing, the book explores lookup-based, distributed, and parallel solutions. It then addresses advanced topics, such as reasoning, and discusses work related to read-write Linked Data for system interoperation. Desp...

  18. Linking numbers for handlebody-links

    OpenAIRE

    Mizusawa, Atsuhiko

    2013-01-01

    As a generalization of the linking number, we construct a set of invariant numbers for two-component handlebody-links. These numbers are elementary divisors associated with the natural homomorphism from the first homology group of a component to that of the complement of another component.

  19. Links and Quantum Entanglement

    CERN Document Server

    Solomon, A I

    2011-01-01

    We discuss the analogy between topological entanglement and quantum entanglement, particularly for tripartite quantum systems. We illustrate our approach by first discussing two clearly (topologically) inequivalent systems of three-ring links: The Borromean rings, in which the removal of any one link leaves the remaining two non-linked (or, by analogy, non-entangled); and an inequivalent system (which we call the NUS link) for which the removal of any one link leaves the remaining two linked (or, entangled in our analogy). We introduce unitary representations for the appropriate Braid Group ($B_3$) which produce the related quantum entangled systems. We finally remark that these two quantum systems, which clearly possess inequivalent entanglement properties, are locally unitarily equivalent.

  20. Linking open vocabularies

    CERN Document Server

    Greifender, Elke; Seadle, Michael

    2013-01-01

    Linked Data (LD), Linked Open Data (LOD) and generating a web of data, present the new knowledge sharing frontier. In a philosophical context, LD is an evolving environment that reflects humankinds' desire to understand the world by drawing on the latest technologies and capabilities of the time. LD, while seemingly a new phenomenon did not emerge overnight; rather it represents the natural progression by which knowledge structures are developed, used, and shared. Linked Open Vocabularies is a significant trajectory of LD. Linked Open Vocabularies targets vocabularies that have traditionally b

  1. Refined Hopf Link Revisited

    CERN Document Server

    Iqbal, Amer

    2012-01-01

    We establish a relation between the refined Hopf link invariant and the S-matrix of the refined Chern-Simons theory. We show that the refined open string partition function corresponding to the Hopf link, calculated using the refined topological vertex, when expressed in the basis of Macdonald polynomials gives the S-matrix of the refined Chern-Simons theory.

  2. Dynamical fat link fermions

    CERN Document Server

    Kamleh, W; Williams, A G; Kamleh, Waseem; Leinweber, Derek B.; Williams, Anthony G.; 10.1016/j.nuclphysbps.2003.12.058

    2004-01-01

    The use of APE smearing or other blocking techniques in fermion actions can provide many advantages. There are many variants of these fat link actions in lattice QCD currently, such as FLIC fermions. Frequently, fat link actions make use of the APE blocking technique in combination with a projection of the blocked links back into the special unitary group. This reunitarisation is often performed using an iterative maximisation of a gauge invariant measure. This technique is not differentiable with respect to the gauge field and thus prevents the use of standard Hybrid Monte Carlo simulation algorithms. The use of an alternative projection technique circumvents this difficulty and allows the simulation of dynamical fat link fermions with standard HMC and its variants.

  3. Linked Ocean Data

    Science.gov (United States)

    Leadbetter, Adam; Arko, Robert; Chandler, Cynthia; Shepherd, Adam

    2014-05-01

    "Linked Data" is a term used in Computer Science to encapsulate a methodology for publishing data and metadata in a structured format so that links may be created and exploited between objects. Berners-Lee (2006) outlines the following four design principles of a Linked Data system: Use Uniform Resource Identifiers (URIs) as names for things. Use HyperText Transfer Protocol (HTTP) URIs so that people can look up those names. When someone looks up a URI, provide useful information, using the standards (Resource Description Framework [RDF] and the RDF query language [SPARQL]). Include links to other URIs so that they can discover more things. In 2010, Berners-Lee revisited his original design plan for Linked Data to encourage data owners along a path to "good Linked Data". This revision involved the creation of a five star rating system for Linked Data outlined below. One star: Available on the web (in any format). Two stars: Available as machine-readable structured data (e.g. An Excel spreadsheet instead of an image scan of a table). Three stars: As two stars plus the use of a non-proprietary format (e.g. Comma Separated Values instead of Excel). Four stars: As three stars plus the use of open standards from the World Wide Web Commission (W3C) (i.e. RDF and SPARQL) to identify things, so that people can point to your data and metadata. Five stars: All the above plus link your data to other people's data to provide context Here we present work building on the SeaDataNet common vocabularies served by the NERC Vocabulary Server, connecting projects such as the Rolling Deck to Repository (R2R) and the Biological and Chemical Oceanography Data Management Office (BCO-DMO) and other vocabularies such as the Marine Metadata Interoperability Ontology Register and Repository and the NASA Global Change Master Directory to create a Linked Ocean Data cloud. Publishing the vocabularies and metadata in standard RDF XML and exposing SPARQL endpoints renders them five-star Linked

  4. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Education Projects » Learn the Link - Drugs and HIV Learn the Link - Drugs and HIV Email Facebook Twitter ... research findings and news updates. Read on to Learn the Link between drug abuse and HIV and ...

  5. Link Monotonic Allocation Schemes

    NARCIS (Netherlands)

    Slikker, M.

    1999-01-01

    A network is a graph where the nodes represent players and the links represent bilateral interaction between the players. A reward game assigns a value to every network on a fixed set of players. An allocation scheme specifies how to distribute the worth of every network among the players. This allo

  6. Linking consumer experiences

    DEFF Research Database (Denmark)

    Smed, Karina Madsen

    become part of the individual self, worldview, and behaviour. This paper seeks to explore links between consumer experiences through the exploration of narrative sequences in travel blogs. Findings indicate that non-consumption is a central element to the bloggers and also indicative of a community...

  7. Helically linked mirror arrangement

    International Nuclear Information System (INIS)

    A scheme is described for helical linking of mirror sections, which endeavors to combine the better features of toroidal and mirror devices by eliminating the longitudinal loss of mirror machines, having moderately high average β and steady state operation. This scheme is aimed at a device, with closed magnetic surfaces having rotational transform for equilibrium, one or more axisymmetric straight sections for reduced radial loss, a simple geometrical axis for the links and an overall positive magnetic well depth for stability. We start by describing several other attempts at linking of mirror sections, made both in the past and the present. Then a description of our helically linked mirror scheme is given. This example has three identical straight sections connected by three sections having helical geometric axes. A theoretical analysis of the magnetic field and single-particle orbits in them leads to the conclusion that most of the passing particles would be confined in the device and they would have orbits independent of pitch angle under certain conditions. Numerical results are presented, which agree well with the theoretical results as far as passing particle orbits are concerned

  8. Volumes of chain links

    CERN Document Server

    Kaiser, James; Rollins, Clint

    2011-01-01

    Agol has conjectured that minimally twisted n-chain links are the smallest volume hyperbolic manifolds with n cusps, for n at most 10. In his thesis, Venzke mentions that these cannot be smallest volume for n at least 11, but does not provide a proof. In this paper, we give a proof of Venzke's statement. The proof for n at least 60 is completely rigorous. The proof for n between 11 and 59 uses a computer calculation, and can be made rigorous for manifolds of small enough complexity, using methods of Moser and Milley. Finally, we prove that the n-chain link with 2m or 2m+1 half-twists cannot be the minimal volume hyperbolic manifold with n cusps, provided n is at least 60 or |m| is at least 8, and we give computational data indicating this remains true for smaller n and |m|.

  9. WEAK LINKS AND DIVERSIFICATION

    OpenAIRE

    Cristian Ugarte

    2014-01-01

    An important literature has shown that the relationship between economic diversification and income per capita is non-monotonic (Imbs and Wacziarg, 2003 and Koren and Tenreyro, 2007). At early stages of development countries diversify as income increases and new economic opportunities emerge, but at later stages of development the production bundle becomes more concentrated as income rises. The aim of this paper is to explore the role played by Weak Links effects à la Jones (2011) in explaini...

  10. Collaboratively Patching Linked Data

    CERN Document Server

    Knuth, Magnus; Sack, Harald

    2012-01-01

    Today's Web of Data is noisy. Linked Data often needs extensive preprocessing to enable efficient use of heterogeneous resources. While consistent and valid data provides the key to efficient data processing and aggregation we are facing two main challenges: (1st) Identification of erroneous facts and tracking their origins in dynamically connected datasets is a difficult task, and (2nd) efforts in the curation of deficient facts in Linked Data are exchanged rather rarely. Since erroneous data often is duplicated and (re-)distributed by mashup applications it is not only the responsibility of a few original publishers to keep their data tidy, but progresses to be a mission for all distributers and consumers of Linked Data too. We present a new approach to expose and to reuse patches on erroneous data to enhance and to add quality information to the Web of Data. The feasibility of our approach is demonstrated by example of a collaborative game that patches statements in DBpedia data and provides notifications ...

  11. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... send the message to young people and to parents, teachers, and the media about the link between ... Send the message to young people and to parents, teachers, and the media about the link between ...

  12. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the Link - Drugs and HIV Learn the Link - Drugs and HIV Email Facebook Twitter 2005 –Ongoing Behaviors ... GA: CDC, DHHS. Retrieved June 2012 How are Drug Abuse and HIV Related? Drug abuse and addiction ...

  13. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the link between drug abuse and HIV infection. It contains information for young people, parents and teachers, ... present time. The virus (HIV) and the disease it causes (AIDS) are often linked and referred to ...

  14. The Connectivity Order of Links

    CERN Document Server

    Dugowson, Stéphane

    2008-01-01

    We associate at each link a connectivity space which describes its splittability properties. Then, the notion of order for finite connectivity spaces results in the definition of a new numerical invariant for links, their connectivity order. A section of this short paper presents a theorem which asserts that every finite connectivity structure can be realized by a link : the Brunn-Debrunner-Kanenobu Theorem.

  15. Link Analysis for Space Communication Links Using ARQ Protocol

    Science.gov (United States)

    Cheung, Kar-Ming; Lau, Chi-Wung; Lee, Charles

    2014-01-01

    In space communications, standard link analysis assumes that messages are sent once. For a communication link that uses an error-correction coding scheme, bit-error-rate (BER) or frame-error-rate (FER), and link margins are common metrics that characterize the quality of a link, and they are used to determine the supportable data rate. With the advent of Automatic Repeat-reQuest (ARQ) protocols, when messages are corrupted during transmission, they can be resent multiple times automatically until they are correctly received and acknowledged. The concept of BER, FER, and link margin cannot be directly applied, and the link analysis approach for ARQ links needs to be re-examined.

  16. Predicting missing links and identifying spurious links via likelihood analysis

    Science.gov (United States)

    Pan, Liming; Zhou, Tao; Lü, Linyuan; Hu, Chin-Kun

    2016-03-01

    Real network data is often incomplete and noisy, where link prediction algorithms and spurious link identification algorithms can be applied. Thus far, it lacks a general method to transform network organizing mechanisms to link prediction algorithms. Here we use an algorithmic framework where a network’s probability is calculated according to a predefined structural Hamiltonian that takes into account the network organizing principles, and a non-observed link is scored by the conditional probability of adding the link to the observed network. Extensive numerical simulations show that the proposed algorithm has remarkably higher accuracy than the state-of-the-art methods in uncovering missing links and identifying spurious links in many complex biological and social networks. Such method also finds applications in exploring the underlying network evolutionary mechanisms.

  17. Linking Wayfinding and Wayfaring

    DEFF Research Database (Denmark)

    Lanng, Ditte Bendix; Jensen, Ole B.

    2016-01-01

    In this chapter we propose to expand and enhance the understanding of wayfi nding beyond the strictly “instrumental” (i.e., getting from point A to point B), to include the qualities and multi-sensorial inputs that inform and shape people’s movement through space. We take as a point of departure...... of environmental information , which includes the embodied, multi-sensorial experience of moving through physical space. We base our examination in part on the classic positions of the wayfi nding literature—for example, Lynch’s seminal study, The Image of the City ( 1960 ). However, we also examine the so......-called mobilities turn in which mobility is viewed as a complex, multilayered process that entails much more than simply getting from point A to point B (see Cresswell 2006 ; Jensen 2013 ; Urry 2007 ).The structure of the chapter is simple: We fi rst introduce the concepts that are key to linking wayfi nding...

  18. Linking to the Future

    Science.gov (United States)

    Moore, John W.

    1999-09-01

    of JCE in the mail each month, and I expect you do too. I can glance at the cover to get an overview of an issue's content, and I usually am enticed inside by intriguing cover art. I can scan the table of contents to find articles I want to read, or I can just browse through the issue to see what looks interesting. Usually the editors have juxtaposed related articles so that I often find a small treasure trove. The printed Journal is quite portable and can be read in a car or airplane. It will last a long time, and until the paper deteriorates, I will never have a problem reading back issues. I have almost every issue from the first day I subscribed and have even added some older ones from collections of retired colleagues who no longer had shelf space for them. I certainly would not want to give up my printed copies, and I want to keep getting them. I find that JCE Online provides a different kind of resource that is equally valuable. It contains more information, and information that is more appropriate in electronic form. It links related ideas into a much more complex web of information than is possible in print. And it opens pathways to lots of information that is not part of JCE but resides elsewhere. Using this issue as an example, let's take a tour of what JCE Online can do. Point your Web browser to http://jchemed.chem.wisc.edu Click on Journal and then on Current Issue (unless September 1999 is no longer the current issue, in which case you will find it in Past Issues). In the table of contents, find the article "UV Catalysis, Cyanotype Photography, and Sunscreens". Click on the title. When the abstract appears, click on Full Text (PDF) to see the article, just as it appears on page 1199 in this issue. When you are prompted, enter the name and subscriber number from your address label. At the end of the article you will find that supplementary materials are available (including a procedure for testing sunscreens) and you can click on the link to view them

  19. Discovering link communities in complex networks by exploiting link dynamics

    International Nuclear Information System (INIS)

    Discovery of communities in complex networks is a fundamental data analysis problem with applications in various domains. Most of the existing approaches have focused on discovering communities of nodes, while recent studies have shown great advantages and utilities of the knowledge of communities of links in networks. From this new perspective, we propose a link dynamics based algorithm, called UELC, for identifying link communities of networks. In UELC, the stochastic process of a link–node–link random walk is employed to unfold an embedded bipartition structure of links in a network. The local mixing properties of the Markov chain underlying the random walk are then utilized to extract two emerging link communities. Further, the random walk and the bipartitioning processes are wrapped in an iterative subdivision strategy to recursively identify link partitions that segregate the network links into multiple subdivisions. We evaluate the performance of the new method on synthetic benchmarks and demonstrate its utility on real-world networks. Our experimental results show that our method is highly effective for discovering link communities in complex networks. As a comparison, we also extend UELC to extracting communities of nodes, and show that it is effective for node community identification. (paper)

  20. Protective link for superconducting coil

    Science.gov (United States)

    Umans, Stephen D.

    2009-12-08

    A superconducting coil system includes a superconducting coil and a protective link of superconducting material coupled to the superconducting coil. A rotating machine includes first and second coils and a protective link of superconducting material. The second coil is operable to rotate with respect to the first coil. One of the first and second coils is a superconducting coil. The protective link is coupled to the superconducting coil.

  1. Relational link-based ranking

    OpenAIRE

    Geerts, Floris; Mannila, Heikki; Terzi, Evimaria

    2004-01-01

    Link analysis methods show that the interconnections between web pages have lots of valuable information. The link analysis methods are, however, inherently oriented towards analyzing binary relations. We consider the question of generalizing link analysis methods for analyzing relational databases. To this aim, we provide a generalized ranking framework and address its practical implications. More specifically, we associate with each relational database and set of queries a unique weig...

  2. "Conjectural" links in complex networks

    OpenAIRE

    Snarskii, A. A.; Zorinets, D. I.; Lande, D. V.

    2016-01-01

    This paper introduces the concept of Conjectural Link for Complex Networks, in particular, social networks. Conjectural Link we understand as an implicit link, not available in the network, but supposed to be present, based on the characteristics of its topology. It is possible, for example, when in the formal description of the network some connections are skipped due to errors, deliberately hidden or withdrawn (e.g. in the case of partial destruction of the network). Introduced a parameter ...

  3. "Conjectural" links in complex networks

    Science.gov (United States)

    Snarskii, A. A.; Zorinets, D. I.; Lande, D. V.

    2016-11-01

    This paper introduces the concept of Conjectural Link for Complex Networks, in particular, social networks. Conjectural Link we understand as an implicit link, not available in the network, but supposed to be present, based on the characteristics of its topology. It is possible, for example, when in the formal description of the network some connections are skipped due to errors, deliberately hidden or withdrawn (e.g. in the case of partial destruction of the network). Introduced a parameter that allows ranking the Conjectural Link. The more this parameter - the more likely that this connection should be present in the network. This paper presents a method of recovery of partially destroyed Complex Networks using Conjectural Links finding. Presented two methods of finding the node pairs that are not linked directly to one another, but have a great possibility of Conjectural Link communication among themselves: a method based on the determination of the resistance between two nodes, and method based on the computation of the lengths of routes between two nodes. Several examples of real networks are reviewed and performed a comparison to know network links prediction methods, not intended to find the missing links in already formed networks.

  4. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available Researchers Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr ...

  5. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs ... HIV Learn the Link - Drugs and HIV Email Facebook Twitter 2005 –Ongoing Behaviors associated with drug abuse ...

  6. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... transmitting HIV/AIDS or other infectious diseases. Research Reports: HIV/AIDS : Explores the link between drug abuse ... at: https://www.drugabuse.gov/news-events/public-education-projects/learn-link-drugs-hiv . 120x90 460x80 486x60 ...

  7. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Learn the Link campaign uses TV, print, and Web public service announcements (PSAs), as well as posters, e-cards, ... to use drugs. The Learn the Link public service campaign is just one ... this Web site. Sincerely, Nora D. Volkow, M.D. Director ...

  8. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs of Abuse Commonly Abused Drugs Charts Emerging ... Badges Other Resources Strategic Plan Search Share Print Home » News & Events » Public Education Projects » Learn the Link - ...

  9. Decouplink: Dynamic Links for Java

    DEFF Research Database (Denmark)

    Jensen, Martin Lykke Rytter; Jørgensen, Bo Nørregaard

    2011-01-01

    of dimensions of extension that can be exploited without performing modification of existing types. Thus, dynamic links make it possible to enforce the open/closed principle in situations where it would otherwise not be possible. We present Decouplink – a library-based implementation of dynamic links for Java...

  10. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the link between drug abuse and HIV/AIDS, populations most at risk, trends in HIV/AIDS, and ... increasingly at risk for HIV infection through risky sexual behaviors. NIDA researchers have studied and continue to study the links between drug abuse and HIV/AIDS. In the early years of ...

  11. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the message to young people and to parents, teachers, and the media about the link between drug abuse and HIV. We have produced a set of ... the message to young people and to parents, teachers, and the media about the link between drug abuse and HIV. Post on Facebook or Twitter ; add ...

  12. Amsterdam Museum Linked Open Data

    NARCIS (Netherlands)

    Boer, V. de; Wielemaker, J.; Gent, J. van; O'Connell, J.; Oosterbroek, M; Hildebrand, M.; Isaac, A.; Ossenbruggen, J.R. van; Schreiber, G.

    2013-01-01

    In this document we describe the Amsterdam Museum Linked Open Data set. The dataset is a five-star Linked Data representation and comprises the entire collection of the Amsterdam Museum consisting of more than 70,000 object descriptions. Furthermore, the institution's thesaurus and person authority

  13. Effect of gastric bypass surgery on mRNA expression level of hepatic phosphoenolpyruvate carboxykinase in type 2 diabetic Goto-Kakizaki rats%胃旁路术对2型糖尿病大鼠肝脏磷酸烯醇式丙酮酸羧激酶mRNA表达的影响

    Institute of Scientific and Technical Information of China (English)

    谢杰斌; 蔡景理; 李立军; 张林君; 姜明哲; 陈登刚; 陈荣

    2012-01-01

    Objective To investigate the effects of gastric bypass surgery(GBP)on hepatic phosphoenolpyruvate carboxykinase(PEPCK)mRNA expression in type 2 diabetic Goto-Kakizaki rats.Methods Male GK rats were randomized into three groups:gastric bypass surgery(n=10),sham operation with diet restriction(n=10),and sham operation alone(n=10).Liver specimens of GK rats were collected during the intraoperative period for self-control study and 8 weeks after surgery.Fasting blood glucose,food intake,and body weight were recorded before surgery and 1,2,4,8 weeks after surgery.The expression of PEPCK mRNA was measured by real-time PCR.Results The fasting plasma glucose level decreased from(17.6±2.1)mmol/L before surgery to(7.5±0.9)mmol/L 8 weeks after surgery in GBP group.The level of PEPCK mRNA decreased from 1.08±0.38 before surgery to 0.41±0.10 8 weeks after surgery,significantly lower than that in sham operation alone group(1.04±0.12)(P<0.01).The level of PEPCK mRNA in diet restriction group increased from 1.15±0.16 before surgery to 2.54±0.82 8 weeks after surgery(P<0.01).The expression of PEPCK mRNA in diet restriction was significantly higher than that in CBP group(P<0.01).Conclusions GBP can significantly improve hyperglycemia in type 2 diabetic GK rat models,which may be associated with the decrease of hepatic PEPCK mRNA level.%目的 研究胃旁路术对2型糖尿病Goto-Kakizaki(GK)大鼠降糖作用及肝脏磷酸烯醇式丙酮酸羧激酶(PEPCK)mRNA表达的影响.方法 将30只12周龄的雄性GK大鼠分为手术组(胃旁路术,10只)、假手术饮食控制组(10只)及假手术空白对照组(10只),术中取各组肝脏标本用于术后对照研究.观察手术前后空腹血糖、进食量及体质量变化情况.术后8周取各组肝脏标本,用实时荧光定量PCR(real-time PCR)检测各组肝脏手术前后PEPCK mRNA的表达变化.结果 术后8周,手术组空腹血糖由术前(17.6±2.1)mmol/L下降至(7.5±0.9)mmol

  14. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available Researchers Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs of Abuse Commonly Abused ...

  15. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... on our website that are available for your use to share on your social media accounts. About the Campaign Overview The Learn the Link campaign uses TV, print, and Web public service announcements (PSAs), ...

  16. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... educational institutions, magazines, newspapers, companies, events, and radio stations for helping to raise awareness of the link ... Poets Sistahs Getting Real About HIV Conference Radio Stations: WTOP Radio WPFW Radio WOL Radio News & Events ...

  17. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available Researchers Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs of Abuse ...

  18. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... abuse and HIV infection. It contains information for young people, parents and teachers, and the media with links ... 177(1):355-361. How are Teens Affected? Young people are at risk for contracting HIV. In general, ...

  19. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... teens and young adults have never known a world without it. NIDA’s "Learn the Link" campaign continues ... the treatment regimen and realizing beneficial outcomes. NIDA research has shown this to be true for people ...

  20. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Addiction Science Adolescent Brain Comorbidity College-Age & Young Adults Criminal Justice Drugged Driving Drug Testing Drugs and ... Link campaign. This campaign shows teens and young adults that non-injection drug use and alcohol use ...

  1. Protein Linked to Atopic Dermatitis

    Science.gov (United States)

    ... Research Matters NIH Research Matters January 14, 2013 Protein Linked to Atopic Dermatitis Normal skin from a ... in mice suggests that lack of a certain protein may trigger atopic dermatitis, the most common type ...

  2. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Abuse, Dr. Nora D. Volkow. Message from the Director The Link Between HIV/AIDS and Drug Abuse ... Web site. Sincerely, Nora D. Volkow, M.D. Director National Institute on Drug Abuse Collaborators Thanks to ...

  3. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... about the link between drug abuse and HIV. We have produced a set of multicultural public service ... many of us think about HIV/AIDS when we’re at parties or hanging out with friends? ...

  4. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... affect anyone. Watch the “d’cisions” Videos Campaign Materials After the Party Posters: We have developed posters ... the Learn the Link message. Campaign messages and materials were tested among various groups of young people, ...

  5. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... patients who do not abuse drugs. In animal studies, methamphetamine has been shown to increase the amount ... behaviors. NIDA researchers have studied and continue to study the links between drug abuse and HIV/AIDS. ...

  6. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs ...

  7. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Web banner ads that you can download and add to your Web site. Please link these banners ... abuse and HIV. Post on Facebook or Twitter ; add photos to your Flickr , Pinterest , and Instagram pages; ...

  8. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... teens and young adults have never known a world without it. NIDA’s "Learn the Link" campaign continues to raise awareness among this generation of the real risks of drug use for transmitting HIV, and ...

  9. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Drugs and HIV Learn the Link - Drugs and HIV Email Facebook Twitter 2005 –Ongoing Behaviors associated with ... Send the Message . Get the Facts What are HIV and AIDS? HIV (human immunodeficiency virus) is the ...

  10. Medicare and Medicaid Linked Files

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Medicare-Medicaid Linked Enrollee Analytic Data Source (MMLEADS) has been developed to allow for the examination of all Medicare and Medicaid enrollment and...

  11. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... transmitting HIV/AIDS or other infectious diseases. Research Reports: HIV/AIDS : Explores the link between drug abuse ... access to the latest, federally approved HIV/AIDS medical practice guidelines, HIV treatment and prevention clinical trials, ...

  12. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... NIDA’s "Learn the Link" campaign continues to raise awareness among this generation of the real risks of ... Collaborators Thanks to Those Who Have Helped Raise Awareness of Our Campaign! NIDA acknowledges the following television ...

  13. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... causes AIDS (acquired immune deficiency syndrome). AIDS is a disease of the immune system for which there ... causes (AIDS) are often linked and referred to as "HIV/AIDS." HIV can be transferred between people ...

  14. Linking Ethics and Economic Growth

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul

    2012-01-01

    Hunt (2012) builds on his work concerning ethics and resource-advantage theory to link personal ethical standards, societal norms, and economic growth but offers few details concerning the precise mechanisms that link ethics and growth. This comment suggests a number of such mechanisms...... – for example, the influence of prevailing ethical norms on the aggregate elasticity of substitution and, therefore, total factor productivity and growth....

  15. Linking water and permafrost dynamics

    OpenAIRE

    Sjöberg, Ylva

    2015-01-01

    The extent and dynamics of permafrost are tightly linked to the distribution and movement of water in arctic landscapes. As the Arctic warms more rapidly than the global average, profound changes are expected in both permafrost and hydrology; however, much is still not known about the interactions between these two systems. The aim of this thesis is to provide new knowledge on the links between permafrost and hydrology under varying environmental conditions and across different scales. The ob...

  16. Linked data and user interaction

    CERN Document Server

    Cervone, H Frank

    2015-01-01

    This collection of research papers provides extensive information on deploying services, concepts, and approaches for using open linked data from libraries and other cultural heritage institutions. With a special emphasis on how libraries and other cultural heritage institutions can create effective end user interfaces using open, linked data or other datasets. These papers are essential reading for any one interesting in user interface design or the semantic web.

  17. Manual de LinkedIn

    OpenAIRE

    Blazquez, Alegría; Oriol BORRÁS GENÉ

    2016-01-01

    Manual básico sobre la red profesional LinkedIn, donde se analiza la red y se explica a fondo cómo crear un perfil y gestionarlo. Incluye información sobre las diferentes secciones características de la red LinkedIn y ofrece consejos para la correcta gestión de un perfil, buscando su mejor rendimiento.

  18. Substrate overload: Glucose oxidation in human myotubes conquers palmitate oxidation through anaplerosis

    DEFF Research Database (Denmark)

    Gaster, Michael

    2009-01-01

    by increasing concentrations of the other in human myotubes established from healthy, lean subjects exposed to acute stepwise increases in glucose and PA levels. At high substrate levels; PA oxidation was reduced while release of acid soluble metabolites was increased and, both glucose oxidation and release...... of citrate was increased which could be abolished by phenylacetic acid (inhibitor of pyruvate carboxylase (PC)). The present data challenges above preconceptions. Although they operate at low-moderate substrate levels additional two principles determine substrate oxidation at higher substrate concentrations......To date, two cardinal principles govern oxidation of glucose and fatty acids in skeletal muscle; exogenous fatty acid reduces glucose oxidation and glucose reduces fatty acid oxidation. Both glucose and palmitate (PA) oxidation was increased by increasing their concentration and inhibited...

  19. The Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows

    Directory of Open Access Journals (Sweden)

    Heather M. White

    2015-08-01

    Full Text Available The transition to lactation period in dairy cattle is characterized by metabolic challenges, negative energy balance, and adipose tissue mobilization. Metabolism of mobilized adipose tissue is part of the adaptive response to negative energy balance in dairy cattle; however, the capacity of the liver to completely oxidize nonesterified fatty acids may be limited and is reflective of oxaloacetate pool, the carbon carrier of the tricarboxylic acid cycle. Alternative metabolic fates of acetyl-CoA from nonesterified fatty acids include esterification to triacylglycerides and ketogenesis, and when excessive, these pathways lead to fatty liver and ketosis. Examination of the anaplerotic and cataplerotic pull of oxaloacetate by the tricarboxylic acid cycle and gluconeogenesis may provide insight into the balance of oxidation and esterification of acetyl-CoA within the liver of periparturient dairy cows.

  20. The Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows.

    Science.gov (United States)

    White, Heather M

    2015-01-01

    The transition to lactation period in dairy cattle is characterized by metabolic challenges, negative energy balance, and adipose tissue mobilization. Metabolism of mobilized adipose tissue is part of the adaptive response to negative energy balance in dairy cattle; however, the capacity of the liver to completely oxidize nonesterified fatty acids may be limited and is reflective of oxaloacetate pool, the carbon carrier of the tricarboxylic acid cycle. Alternative metabolic fates of acetyl-CoA from nonesterified fatty acids include esterification to triacylglycerides and ketogenesis, and when excessive, these pathways lead to fatty liver and ketosis. Examination of the anaplerotic and cataplerotic pull of oxaloacetate by the tricarboxylic acid cycle and gluconeogenesis may provide insight into the balance of oxidation and esterification of acetyl-CoA within the liver of periparturient dairy cows. PMID:26479386

  1. LinkMind: Link Optimization in Swarming Mobile Sensor Networks

    Directory of Open Access Journals (Sweden)

    Trung Dung Ngo

    2011-08-01

    Full Text Available A swarming mobile sensor network is comprised of a swarm of wirelessly connected mobile robots equipped with various sensors. Such a network can be applied in an uncertain environment for services such as cooperative navigation and exploration, object identification and information gathering. One of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximize the transmission of gathered data from a source to a target. This paper describes a new method of link optimization of swarming mobile sensor networks. The new method is based on combination of the artificial potential force guaranteeing connectivities of the mobile sensor nodes and the max-flow min-cut theorem of graph theory ensuring optimization of the network link capacity. The developed algorithm is demonstrated and evaluated in simulation.

  2. LinkMind: Link Optimization in Swarming Mobile Sensor Networks

    DEFF Research Database (Denmark)

    Ngo, Trung Dung

    2012-01-01

    optimization of swarming mobile sensor networks. The new method is based on combination of the artificial potential force guaranteeing connectivities of the mobile sensor nodes and the max-flow min-cut theorem of graph theory ensuring optimization of the network link capacity. The developed algorithm......A swarming mobile sensor network is comprised of a swarm of wirelessly connected mobile robots equipped with various sensors. Such a network can be applied in an uncertain environment for services such as cooperative navigation and exploration, object identification and information gathering. One...... of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximize the transmission of gathered data from a source to a target. This paper describes a new method of link...

  3. LinkMind: link optimization in swarming mobile sensor networks.

    Science.gov (United States)

    Ngo, Trung Dung

    2011-01-01

    A swarming mobile sensor network is comprised of a swarm of wirelessly connected mobile robots equipped with various sensors. Such a network can be applied in an uncertain environment for services such as cooperative navigation and exploration, object identification and information gathering. One of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximize the transmission of gathered data from a source to a target. This paper describes a new method of link optimization of swarming mobile sensor networks. The new method is based on combination of the artificial potential force guaranteeing connectivities of the mobile sensor nodes and the max-flow min-cut theorem of graph theory ensuring optimization of the network link capacity. The developed algorithm is demonstrated and evaluated in simulation.

  4. SetLink the CERN Document Server Link Manager

    CERN Document Server

    Le Meur, Jean-Yves

    2000-01-01

    This paper analyses the problems encountered by electronic libraries to cope with long term keeping of on-line documents. What is thebest solution not to fill in a library system with non persistent addresses ? Different possible solutions are studied, based on theexperience of the CERN Document Server and its library. This paper will stress the importance of using a Link Manager for any long term Web server. It will explain how the CERN SetLink Link Manager is designed to handle a wide range of document types and formats, from photos in JPEG to eprints in PDF. It will also focus onother possibilities offered by using such an application, like automatic figures extraction or concatenation, full text searching andon-the-fly format conversions.

  5. LinkMind: link optimization in swarming mobile sensor networks.

    Science.gov (United States)

    Ngo, Trung Dung

    2011-01-01

    A swarming mobile sensor network is comprised of a swarm of wirelessly connected mobile robots equipped with various sensors. Such a network can be applied in an uncertain environment for services such as cooperative navigation and exploration, object identification and information gathering. One of the most advantageous properties of the swarming wireless sensor network is that mobile nodes can work cooperatively to organize an ad-hoc network and optimize the network link capacity to maximize the transmission of gathered data from a source to a target. This paper describes a new method of link optimization of swarming mobile sensor networks. The new method is based on combination of the artificial potential force guaranteeing connectivities of the mobile sensor nodes and the max-flow min-cut theorem of graph theory ensuring optimization of the network link capacity. The developed algorithm is demonstrated and evaluated in simulation. PMID:22164070

  6. Seismic link at plate boundary

    Indian Academy of Sciences (India)

    Faical Ramdani; Omar Kettani; Benaissa Tadili

    2015-06-01

    Seismic triggering at plate boundaries has a very complex nature that includes seismic events at varying distances. The spatial orientation of triggering cannot be reduced to sequences from the main shocks. Seismic waves propagate at all times in all directions, particularly in highly active zones. No direct evidence can be obtained regarding which earthquakes trigger the shocks. The first approach is to determine the potential linked zones where triggering may occur. The second step is to determine the causality between the events and their triggered shocks. The spatial orientation of the links between events is established from pre-ordered networks and the adapted dependence of the spatio-temporal occurrence of earthquakes. Based on a coefficient of synchronous seismic activity to grid couples, we derive a network link by each threshold. The links of high thresholds are tested using the coherence of time series to determine the causality and related orientation. The resulting link orientations at the plate boundary conditions indicate that causal triggering seems to be localized along a major fault, as a stress transfer between two major faults, and parallel to the geothermal area extension.

  7. Deformation of Linked Polymer Coils

    Institute of Scientific and Technical Information of China (English)

    董朝霞; 李明远; 吴肇亮; 林梅钦

    2003-01-01

    Linked polymer solution (LPS) is defined as the solution of linked polymer coils (LPCs) dispersed in water, composed of low concentration partially hydrolyzed polyacrylamide (HPAM) and aluminum citrate (crosslinker). In the work, the conformational changes of LPCs under different conditions were investigated by the methods of membrane filtering under low pressure, dynamic light scattering and core flooding experiments. The results showed that in some conditions the LPCs could be compressed mechanically to 1/158.5 of their original volume because of relatively lower HPAM cross-linking. The hydration property of LPCs was similar to that of normal polymer coils. The deformation of LPCs was more restricted than that of ordinary polymer coils under the flow shear stress or the shift of hydration equilibrium caused in the variation of the electrolyte concentration which is responsible for the effective plugging in the throats of porous media when LPCs are used for deep diverting.

  8. On ω-Linked Overrings

    Institute of Scientific and Technical Information of China (English)

    Lin XIE; Fang Gui WANG; Yan TIAN

    2011-01-01

    Let R (C) T be an extension of commutative rings. T is called ω-linked over R if T as an R-module is a ω-module. In the case of R (C) T (C) Q0(R), T is called a ω-linked overring of R. As a generalization of Wang-McCsland-Park-Chang Theorem, we show that if R is a reduced ring, then R is a ω-Noetherian ring with ω-dim(R) ≤1 if and only if each ω-linked overring T of R is a ω-Noetherian ring with ω-dim(T) ≤ 1. In particular, R is a ω-Noetherian ring with ω-dim(R) = 0 if and only if R is an Artinian ring.

  9. Link Prediction via Matrix Completion

    CERN Document Server

    Pech, Ratha; Pan, Liming; Cheng, Hong; Zhou, Tao

    2016-01-01

    Inspired by practical importance of social networks, economic networks, biological networks and so on, studies on large and complex networks have attracted a surge of attentions in the recent years. Link prediction is a fundamental issue to understand the mechanisms by which new links are added to the networks. We introduce the method of robust principal component analysis (robust PCA) into link prediction, and estimate the missing entries of the adjacency matrix. On one hand, our algorithm is based on the sparsity and low rank property of the matrix, on the other hand, it also performs very well when the network is dense. This is because a relatively dense real network is also sparse in comparison to the complete graph. According to extensive experiments on real networks from disparate fields, when the target network is connected and sufficiently dense, whatever it is weighted or unweighted, our method is demonstrated to be very effective and with prediction accuracy being considerably improved comparing wit...

  10. When He Said Linking, He Really Meant Linking

    Science.gov (United States)

    Chudnov, Daniel

    2009-01-01

    There are many reasons to improve web links, starting with their design. The author tends to think about "design" on the web in terms of two things: (1) graphic/industrial design; and (2) human usability. A nice, clean URI (uniform resource identifier) that does not change, is readable to humans, is amenable to common web behaviors such as…

  11. Crosscap Numbers of Two-component Links

    OpenAIRE

    Zhang, Gengyu

    2006-01-01

    We define the crosscap number of a 2-component link as the minimum of the first Betti numbers of connected, non-orientable surfaces bounding the link. We discuss some properties of the crosscap numbers of 2-component links.

  12. X-linked Alport syndrome

    DEFF Research Database (Denmark)

    Jais, J P; Knebelmann, B; Giatras, I;

    2000-01-01

    -linked transmission, were collected. Characteristics of the 401 male patients belonging to the 195 families with COL4A5 mutation are presented. All male patients were hematuric, and the rate of progression to end-stage renal failure and deafness was mutation-dependent. Large deletions, non-sense mutations, or small...

  13. Linking Education to the Economy.

    Science.gov (United States)

    Neuschel, Robert P.; And Others

    The papers in this section of the proceedings of the 1981 World Assembly of the International Council on Education for Teaching concern educational reforms and how they can address national economic needs. An introductory article by Robert P. Neuschel, "Linking Education to the Economy: An Introductory Statement," discusses the relationship that…

  14. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available Researchers Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu Home Drugs of Abuse Commonly Abused Drugs Charts Emerging Trends and Alerts Alcohol Club ...

  15. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... About NIDA Director's Page Organization Legislative Activities Advisory Boards & Groups Working at NIDA Donating to NIDA Contact Us Sharing Tools and Badges Other Resources Strategic Plan Search Share Print Home » News & Events » Public Education Projects » Learn the Link - Drugs and HIV Learn ...

  16. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... projects/learn-link-drugs-hiv . 120x90 460x80 486x60 Social Media Send the message to young people and ... available for your use to share on your social media accounts. About the Campaign Overview The Learn ...

  17. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... projects/learn-link-drugs-hiv . 120x90 460x80 486x60 Social Media Send the message to young people and to ... available for your use to share on your social media accounts. About the Campaign Overview The Learn the ...

  18. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... the News NIDA Notes Podcasts E-Newsletters Public Education Projects Contact the Press Office Meetings & Events Media ... Plan Search Share Print Home » News & Events » Public Education Projects » Learn the Link - Drugs and HIV Learn ...

  19. Is Wikipedia link structure different?

    NARCIS (Netherlands)

    J. Kamps; M. Koolen

    2009-01-01

    In this paper, we investigate the difference between Wikipedia and Web link structure with respect to their value as indicators of the relevance of a page for a given topic of request. Our experimental evidence is from two IR test-collections: the .GOV collection used at the TREC Web tracks and the

  20. What Is Linked Historical Data?

    NARCIS (Netherlands)

    Meroño-Peñuela, Albert; Hoekstra, Rinke; Janowicz, Krzysztof; Schlobach, Stefan; Lambrix, Patrick; Hyvönen, Eero

    2014-01-01

    Datasets that represent historical sources are relative new- comers in the Linked Open Data (LOD) cloud. Following the standard LOD practices for publishing historical sources raises several questions: how can we distinguish between RDF graphs of primary and secondary sources? Should we treat archiv

  1. What is Linked Historical Data?

    NARCIS (Netherlands)

    A. Meroño-Peñuela; R. Hoekstra

    2014-01-01

    Datasets that represent historical sources are relative newcomers in the Linked Open Data (LOD) cloud. Following the standard LOD practices for publishing historical sources raises several questions: how can we distinguish between RDF graphs of primary and secondary sources? Should we treat archived

  2. Links between metabolism and cancer

    OpenAIRE

    Dang, Chi V.

    2012-01-01

    Excessive caloric intake is associated with increased risk for cancer, while the nonobese state may be protective through mechanisms that reduce oxidative stress. In this review, Dang discusses the links between metabolism and cancer, which range from the low incidence of cancer in large mammals with low specific metabolic rates to altered cancer cell metabolism resulting from mutated enzymes or cancer genes.

  3. Linking integration and residential segregation

    NARCIS (Netherlands)

    Bolt, G.S.; Özüekren, A.S.; Phillips, Deborah

    2010-01-01

    In the introduction to this special issue of JEMS, we question the strong link which is often made between the integration of minority ethnic groups and their residential segregation. In the literature on neighbourhood effects, the residential concentration of minorities is seen as a major obstacle

  4. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... with HIV is a key predictor of the development of AIDS. Because of their compromised immune system, ... at: https://www.drugabuse.gov/news-events/public-education-projects/learn-link-drugs-hiv . 120x90 460x80 486x60 ...

  5. Tweaking Synchronisation by Link Addition

    CERN Document Server

    Schultz, Paul; Eroglu, Deniz; Stemler, Thomas; Ávila, G Marcelo Ramírez; Rodrigues, Francisco A; Kurths, Jürgen

    2016-01-01

    Natural and man-made networks often possess locally tree-like sub-structures. Taking such tree networks as our starting point, we show how the addition of links changes the synchronization properties of the network. We focus on two different methods of link addition. The first method adds single links that create cycles of a well-defined length. Following a topological approach we introduce cycles of varying length and analyze how this feature, as well as the position in the network, alters the synchronous behaviour. We show that in particular short cycles can lead to a maximum change of the Laplacian's eigenvalue spectrum, dictating the synchronization properties of such networks. The second method connects a certain proportion of the initially unconnected nodes. We simulate dynamical systems on these network topologies, with the nodes' local dynamics being either a discrete or continuous. Here our main result is that a certain amount of additional links, with the relative position in the network being cruci...

  6. Linking aboveground and belowground diversity

    NARCIS (Netherlands)

    Deyn, de G.B.; Putten, van der W.H.

    2005-01-01

    Aboveground and belowground species interactions drive ecosystem properties at the local scale, but it is unclear how these relationships scale-up to regional and global scales. Here, we discuss our current knowledge of aboveground and belowground diversity links from a global to a local scale. Glob

  7. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available Researchers Medical & Health Professionals Patients & Families Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter ... Brain Genetics Global Health Hepatitis (Viral) HIV/AIDS Medical Consequences Mental Health Military Pain Prevention Treatment Trends & ...

  8. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... CDC, DHHS. Retrieved June 2012 How are Drug Abuse and HIV Related? Drug abuse and addiction have been linked with HIV/AIDS ... this regard, the role that non-injection drug abuse plays in the spread of HIV is less ...

  9. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... Send the Message . Get the Facts What are HIV and AIDS? HIV (human immunodeficiency virus) is the virus that ... AIDS) are often linked and referred to as "HIV/AIDS." HIV can be transferred between people if an ...

  10. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... News NIDA Notes Podcasts E-Newsletters Public Education Projects Contact the Press Office Meetings & Events Media Guide ... Search Share Print Home » News & Events » Public Education Projects » Learn the Link - Drugs and HIV Learn the ...

  11. Drugs + HIV, Learn the Link

    Medline Plus

    Full Text Available ... send the message to young people and to parents, teachers, and the media about the link between drug abuse and HIV. We have produced a set of multicultural public service announcements (PSAs) that use text messaging as a means of communication. The "Text Message" PSA features two young girls ...

  12. Linking Customer Interaction and Innovation

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Laursen, Keld; Pedersen, Torben

    2011-01-01

    employees for sharing and acquiring knowledge, and high levels of delegation of decision rights. In this paper, six hypotheses were developed and tested on a data set of 169 Danish firms drawn from a 2001 survey of the 1,000 largest firms in Denmark. A key result is that the link from customer knowledge...

  13. New links in the family

    NARCIS (Netherlands)

    Marion Duimel; Jos de Haan

    2007-01-01

    Original title: Nieuwe links in het gezin. Virtually all families with teenagers have at least one computer with an Internet connection, often more. Teenagers spend much of their daily lives on the Internet. They use it to communicate with each other, to do their schoolwork, to meet new friends and

  14. LCSH, SKOS and Linked Data

    CERN Document Server

    Summers, Ed; Redding, Clay; Krech, Dan

    2008-01-01

    A technique for converting Library of Congress Subject Headings MARCXML to Simple Knowledge Organization System (SKOS) RDF is described. Strengths of the SKOS vocabulary are highlighted, as well as possible points for extension, and the integration of other semantic web vocabularies such as Dublin Core. An application for making the vocabulary available as linked-data on the Web is also described.

  15. Architecture of Platonic and Archimedean polyhedral links

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A new methodology for understanding the construction of polyhedral links has been developed on the basis of the Platonic and Archimedean solids by using our method of the 'three-cross-curve and doubletwist-line covering'. There are five classes of polyhedral links that can be explored: the tetrahedral and truncated tetrahedral links; the hexahedral and truncated hexahedral links; the dodecahedral and truncated dodecahedral links; the truncated octahedral and icosahedral links. Our results show that the tetrahedral and truncated tetrahedral links have T symmetry; the hexahedral and truncated hexahedral links, as well as the truncated octahedral links, O symmetry; the dodecahedral and truncated dodecahedral links, as well as the truncated icosahedral links, I symmetry, respectively. This study provides further insight into the molecular design, as well as theoretical characterization, of the DNA and protein catenanes.

  16. Architecture of Platonic and Archimedean polyhedral links

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A new methodology for understanding the construction of polyhedral links has been developed on the basis of the Platonic and Archimedean solids by using our method of the ‘three-cross-curve and dou- ble-twist-line covering’. There are five classes of polyhedral links that can be explored: the tetrahedral and truncated tetrahedral links; the hexahedral and truncated hexahedral links; the dodecahedral and truncated dodecahedral links; the truncated octahedral and icosahedral links. Our results show that the tetrahedral and truncated tetrahedral links have T symmetry; the hexahedral and truncated hexahedral links, as well as the truncated octahedral links, O symmetry; the dodecahedral and truncated dodeca- hedral links, as well as the truncated icosahedral links, I symmetry, respectively. This study provides further insight into the molecular design, as well as theoretical characterization, of the DNA and protein catenanes.

  17. X-linked Alport syndrome

    DEFF Research Database (Denmark)

    Jais, Jean Philippe; Knebelmann, Bertrand; Giatras, Iannis;

    2003-01-01

    Alport syndrome (AS) is a type IV collagen hereditary disease characterized by progressive hematuric nephritis, hearing loss, and ocular changes. Mutations in the COL4A5 collagen gene are responsible for the more common X-linked dominant form of the disease characterized by much less severe disease...... in girls and women. A "European Community Alport Syndrome Concerted Action" (ECASCA) group was established to delineate the Alport syndrome phenotype in each gender and to determine genotype-phenotype correlations in a large number of families. Data concerning 329 families, 250 of them with an X...... to increase after the age of 60 yr in women. Because of the absence of genotype-phenotype correlation and the large intrafamilial phenotypic heterogeneity, early prognosis of the disease in X-linked Alport syndrome carriers remains moot. Risk factors for developing renal failure have been identified...

  18. Using turbocodes on optical links

    Directory of Open Access Journals (Sweden)

    Glenn Claes

    2006-04-01

    Full Text Available The fast evolving telecommunication world is permanently in search for faster and better communication links. On one hand, turbo codes are like a dream come true. Due to their amazing performance, they have become the reference in the word of error detecting and correcting codes. On the other hand, broadband transmission channels like optical fibres can meet the need for higher transmission velocity. In this paper therefore we will bring these two elements together and thus the performance of turbocodes on optical links will be studied. First the turbocode will be optimised throughout an individual analysis of each of its design parameters. Moreover it wil be shown that turbocodes have much better performance than the well known Reed-Solomon codes. Finally we will show that the 8Bit/10Bit code, which is required to comply with the Gigabit Ethernet standard, becomes superfluous when working with turbocodes. All tests were carried out on multimode graded-index glass fibres.

  19. Collagen cross linking: Current perspectives

    Directory of Open Access Journals (Sweden)

    Srinivas K Rao

    2013-01-01

    Full Text Available Keratoconus is a common ectatic disorder occurring in more than 1 in 1,000 individuals. The condition typically starts in adolescence and early adulthood. It is a disease with an uncertain cause and its progression is unpredictable, but in extreme cases, vision deteriorates and can require corneal transplant surgery. Corneal collagen cross-linking (CCL with riboflavin (C3R is a recent treatment option that can enhance the rigidity of the cornea and prevent disease progression. Since its inception, the procedure has evolved with newer instrumentation, surgical techniques, and is also now performed for expanded indications other than keratoconus. With increasing experience, newer guidelines regarding optimization of patient selection, the spectrum of complications and their management, and combination procedures are being described. This article in conjunction with the others in this issue, will try and explore the uses of collagen cross-linking (CXL in its current form.

  20. The Øresund Link

    DEFF Research Database (Denmark)

    Møller, Jacob Steen

    conducted by the owner of the link constituted the basis for an innovative environmental management plan that resulted in zero impact on the water exchange and full compliance with authorities regulations regarding the local environment. The environmental management was based on integrated use......-km link across the Sound could potentially impact the water exchange between the Baltic Sea and the North Sea, and the dredging activities during construction were a threat to the local marine environment. The public interest in the environmental issues together with a pro-active environmental policy...... of hydrodynamic modelling, on line monitoring and access to all environmental information through a GIS based information system. The public attitude towards the project in general and the environmental impact in particular shifted from a very sceptical one at the beginning of the project to a very positive one...

  1. Terrestrial teleconnections link global rivers

    Science.gov (United States)

    O'Loughlin, F.; Howden, N. J.; Woods, R. A.; Bates, P. D.

    2013-12-01

    We present analyses of river discharge data from across the world, which we used to identify links between annual river flow regimes across different continents. Our hypothesis was that, as atmospheric processes are subject to large-scale teleconnection patterns, and because these atmospheric processes are inherently linked to precipitation regimes across the world, there should be identifiable links between river flow regimes driven by these atmospheric processes. We used discharge data from the Global Runoff Data Centre (GRDC) to identify cross-correlations (and accounted for serial dependence) between 23 of the world's largest river basins where overlapping data were available over a period of 12 years or more: two in South America; five in Africa; one in Australasia; five in North America and ten in Eurasia. The selected river basins drain approximately a third of the Earth's landmass at their furthest downstream gauging station. Where significant cross-correlations were found, we compared these to known patterns associated with the ENSO and NAO teleconnections. In total, 85 of the 253 possible correlations were deemed significant at p0). We compared these significant cross-correlations with known atmospheric teleconnection patterns, and while these were consistent for the majority of cases, we found a number of significant correlations that are inconsistent with the anticipated effects of known atmospheric teleconnections. Our results provide new insight into the inter-continental links between global river systems and the way in which these are controlled by large-scale atmospheric processes. We suggest this may be useful for global industries, such as insurers or aid agencies, who seek to understand correlations between the magnitudes of extreme events across different regions of the world. For the former, this may enable more efficient management of global liabilities, for the latter it may enable better logistical planning of disaster relief requirements

  2. The Nature and Health Link

    OpenAIRE

    Ichoku, Chioma

    2015-01-01

    Undergraduate Independent Study Nature is often overlooked in the health field, and more specifically the physical therapy field. There is evidence that contact with nature has healing effects both psychologically and physically. When it comes to physical therapy, incorporating nature into the regime may provide added benefits. Perhaps it is time that physical therapy consider a research agenda to explore the link. Once benefits are clearly established and outcomes assessed, the field shou...

  3. What Is Linked Historical Data?

    OpenAIRE

    Meroño-Peñuela, Albert; Hoekstra, Rinke; Janowicz, Krzysztof; Schlobach, Stefan; Lambrix, Patrick; Hyvönen, Eero

    2014-01-01

    Datasets that represent historical sources are relative new- comers in the Linked Open Data (LOD) cloud. Following the standard LOD practices for publishing historical sources raises several questions: how can we distinguish between RDF graphs of primary and secondary sources? Should we treat archived and online RDF graphs differently in historical research? How do we deal with change and immutability of a triplified History? To answer these fundamental questions, we model historical primary ...

  4. Transactional capability: Innovation's missing link

    Directory of Open Access Journals (Sweden)

    Jorge Tello-Gamarra

    2013-06-01

    Full Text Available The topic of innovation as a source of competitive advantage for firms is consolidated in the literature. An innovation-based advantage is generally achieved by following a structured process, in which technological capability plays a key role. However, a question remains in studies into innovation, which is concerned with the reasons why not all firms that develop a technological capability are innovative. Where is the missing link? Great efforts have been made in attempts to answer to this question. However, the study of this link as a source of advantage for firms deserves further attention. This article aims to present a framework with two essential dimensions: (1 the technological capability and (2 the transactional capability. Technological capability is the ability of firms to make effective use of technical knowledge in order to improve production processes and develop new products and services. Transactional capability is defined as a repertoire of abilities, processes, experiences, skills, knowledge and routines that the firm uses to minimize its transaction costs (ex¿ante and ex¿post. Given that the present study is a theoretical paper, methodologically it is based on a literature review. The main finding of this study is the identification of transactional capability as the missing link in innovation. Accordingly, to be innovative, in addition to having a technological capability, a firm needs to develop its transactional capability.

  5. Managing Your Team's Weakest Link.

    Science.gov (United States)

    Hills, Laura

    2015-01-01

    Do you have a poor-performing employee on your medical practice team? If so, you're not alone. Unfortunately, this is a problem that many medical practice managers face. This article describes the best strategies for managing your team's weakest link. It explores common yet very difficult circumstances that cause low employee performance and that test the patience, heart, and skills of a practice manager. It guides readers through a process of self-discovery to determine whether their negative biases or grudges may be causing employees to perform poorly. It suggests several possible other reasons for weak employee performance, including problems with the job, practice, leadership, communication, and fit between the employee and the job. This article also suggests the best strategy for communicating concerns about performance to the weakest-link employee. It offers guidance to practice managers about protecting their time and energy when handling a poor performer. It provides a simple formula for calculating the cost of a low-performing employee, 10 possible personal reasons for the employee's poor work performance, specific questions to ask to uncover the reasons for poor performance, and an eight-rule strategy for confronting poor performance effectively. Finally, this article offers practice managers a practical strategy for handling resistance from their weakest link, illustrated with a sample dialogue.

  6. Managing Your Team's Weakest Link.

    Science.gov (United States)

    Hills, Laura

    2015-01-01

    Do you have a poor-performing employee on your medical practice team? If so, you're not alone. Unfortunately, this is a problem that many medical practice managers face. This article describes the best strategies for managing your team's weakest link. It explores common yet very difficult circumstances that cause low employee performance and that test the patience, heart, and skills of a practice manager. It guides readers through a process of self-discovery to determine whether their negative biases or grudges may be causing employees to perform poorly. It suggests several possible other reasons for weak employee performance, including problems with the job, practice, leadership, communication, and fit between the employee and the job. This article also suggests the best strategy for communicating concerns about performance to the weakest-link employee. It offers guidance to practice managers about protecting their time and energy when handling a poor performer. It provides a simple formula for calculating the cost of a low-performing employee, 10 possible personal reasons for the employee's poor work performance, specific questions to ask to uncover the reasons for poor performance, and an eight-rule strategy for confronting poor performance effectively. Finally, this article offers practice managers a practical strategy for handling resistance from their weakest link, illustrated with a sample dialogue. PMID:26223114

  7. Linking GHG Emission Trading Systems and Markets

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    Several different types of links are possible between different GHG-mitigation systems. These include: Linking two or more emission trading schemes so that emissions trading can occur both within and between different schemes ('direct links'); and Linking emission trading systems to registries/mechanisms and systems that generate offsets from project based mechanisms or from direct purchases/transfers of AAUs ('indirect links').

  8. Provenance in Linked Data Integration

    OpenAIRE

    Omitola, Temitope; Gibbins, Nicholas; Shadbolt, Nigel

    2010-01-01

    The open world of the (Semantic) Web is a global information space offering diverse materials of disparate qualities, and the opportunity to re-use, aggregate, and integrate these materials in novel ways. The advent of Linked Data brings the potential to expose data on the Web, creating new challenges for data consumers who want to integrate these data. One challenge is the ability, for users, to elicit the reliability and/or the accuracy of the data they come across. In this paper, we descri...

  9. Brazil-Africa geological links

    Science.gov (United States)

    Torquato, Joaquim Raul; Cordani, Umberto G.

    1981-04-01

    In this work, the main evidence and conclusions regarding geological links between Brazil and Africa are summarized, with emphasis on the geochronological aspects. Taking into account the geographical position, as well as the similarities in the geochronological pattern, the following main provinces of the two continents are correlated: The Imataca and Falawatra complexes in the Guayana Shield and the Liberian Province of West Africa. The Paraguay-Araguaia and the Rockelide Fold Belts. The Sa˜o Luiz and the West African cratonic areas. The Caririan Fold Belt of northeastern Brazil and the Pan-Africa Belt of Nigeria and Cameroon. The JequiéComplex of Bahia, the Ntem Complex of Cameroon and similar rocks of Gabon and Angola. The Ribeira Fold Belt in Brazil and the West Congo and Damara Belts in West and South Africa. In addition, other geological links are considered, such as some of the major linear fault zones which can be traced across the margins of South America and Africa, in the pre-drift reconstructions. Correlations are also made of the tectonic and stratigraphic evolution of the Paranáand Karroo syneclises, and the Brazilian and African marginal basins around the South Atlantic, during their initial stages. Finally, several similarities in the tectonic evolution of South America and Africa, during and after the onset of drifting, are shown to be compatible with a recent origin for the South Atlantic floor, as required by sea-floor spreading and continental drift between South America and Africa.

  10. Researchers Pinpoint More Genes Linked to Vitiligo

    Science.gov (United States)

    ... 161452.html Researchers Pinpoint More Genes Linked to Vitiligo Genetic clues to this autoimmune disease could lead ... identified more genes linked to the autoimmune disease vitiligo, which causes patches of white skin and hair. ...

  11. Zika Linked to Deformed Limbs in Newborns

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_160324.html Zika Linked to Deformed Limbs in Newborns Cause isn' ... 2016 TUESDAY, Aug. 9, 2016 (HealthDay News) -- The Zika virus has already been linked to serious birth ...

  12. Network error correction with unequal link capacities

    OpenAIRE

    Kim, Sukwon; Ho, Tracey; Effros, Michelle; Avestimehr, Amir Salman

    2010-01-01

    We study network error correction with unequal link capacities. Previous results on network error correction assume unit link capacities. We consider network error correction codes that can correct arbitrary errors occurring on up to z links. We find the capacity of a network consisting of parallel links, and a generalized Singleton outer bound for any arbitrary network. We show by example that linear coding is insufficient for achieving capacity in general. In our exampl...

  13. Track with overlapping links for dry coal extrusion pumps

    Science.gov (United States)

    Saunders, Timothy; Brady, John D

    2014-01-21

    A chain for a particulate material extrusion pump includes a plurality of links, each of the plurality of links having a link body and a link ledge, wherein each link ledge of the plurality of links at least partially overlaps the link body of an adjacent one of the plurality of links.

  14. Education and Liberalism: Pursuing the Link

    Science.gov (United States)

    Surridge, Paula

    2016-01-01

    This paper uses data from the 1970 Birth Cohort Study in the UK to explore the well-established link between "liberal" social values and education. Whilst the link itself is well-established, the underlying mechanism is not; the paper explores empirically mechanisms that have been proposed for this link. In particular it considers the…

  15. Electrospinning formaldehyde cross-linked zein solutions

    Science.gov (United States)

    In order to develop zein fibers with improved physical properties and solvent resistance, formaldehyde was used as the cross-linking reagent before spinning. The cross-linking reaction was carried out in either acetic acid or ethanolic-HCl where the amount of cross-linking reagent was between 1 and...

  16. Link Anchors in Images: Is there Truth?

    NARCIS (Netherlands)

    Aly, Robin; McGuinness, Kevin; Kleppe, Martijn; Ordelman, Roeland; O'Connor, Noel; Jong, de Franciska

    2012-01-01

    While automatic linking in text collections is well understood, little is known about links in images. In this work, we investigate two aspects of anchors, the origin of a link, in images: 1) the requirements of users for such anchors, e.g. the things users would like more information on, and 2) pos

  17. MidLink Magazine: The Quintessential Collaborative!

    Science.gov (United States)

    McCullen, Caroline

    1999-01-01

    Discusses MidLink Magazine, "the Digital Magazine for Kids, by Kids," that is supported by SAS in School, North Carolina State University, and the University of Central Florida. Describes what a typical MidLink Magazine article looks like, the MidLink Menu that features real working models of technology integration in every discipline, and teacher…

  18. Data links for the EOS TPC

    International Nuclear Information System (INIS)

    We report on the design and performance of high speed data links and slower configuration control links used between the EOS TPC detector and the data processing electronics. Data rates of 5MBytes/s/link are maintained over 30m with optical isolation. Pedestal subtraction, hit detection, and data reordering are performed online. 3 refs., 1 fig

  19. Broken links and black boxes

    DEFF Research Database (Denmark)

    Sindbæk, Søren Michael

    2013-01-01

    Long-distance communication has emerged as a particular focus for archaeological exploration using network theory, analysis, and modelling. Initial attempts to adapt methods from social network analysis to archaeological data have, however, struggled to produce decisive results. This paper argues...... that the archaeological study of communication networks in the past calls for radically different analytical methods from those employed by most other forms of social network analysis. The fragmentary archaeological evidence presents researchers with the task of reconstructing the broken links of a ruined network from...... observable distributions and patterns of association in the archaeological record. In formal terms this is not a problem of network analysis, but network synthesis: the classic problem of cracking codes or reconstructing black-box circuits....

  20. Property Testing on Linked Lists

    DEFF Research Database (Denmark)

    Afshani, Peyman; Matulef, Kevin; Wilkinson, Bryan Thomas

    2013-01-01

    a list is sorted (monotone increasing) versus a constant distance from sorted. Our bound is strictly greater than the (logn) queries required in the standard testing model, that allows element access indexed by rank, and strictly less than the (n12) queries required by a weak model that only allows......We define a new property testing model for algorithms that do not have arbitrary query access to the input, but must instead traverse it in a manner that respects the underlying data structure in which it is stored. In particular, we consider the case when the underlying data structure is a linked...... list, and the testing algorithm is allowed to either sample randomly from the list, or walk to nodes that are adjacent to those already visited. We study the well-known monotonicity testing problem in this model, and show that (n13) queries are both necessary and sufficient to distinguish whether...

  1. Characterising Web Site Link Structure

    CERN Document Server

    Zhou, Shi; Petricek, Vaclav

    2007-01-01

    The topological structures of the Internet and the Web have received considerable attention. However, there has been little research on the topological properties of individual web sites. In this paper, we consider whether web sites (as opposed to the entire Web) exhibit structural similarities. To do so, we exhaustively crawled 18 web sites as diverse as governmental departments, commercial companies and university departments in different countries. These web sites consisted of as little as a few thousand pages to millions of pages. Statistical analysis of these 18 sites revealed that the internal link structure of the web sites are significantly different when measured with first and second-order topological properties, i.e. properties based on the connectivity of an individual or a pairs of nodes. However, examination of a third-order topological property that consider the connectivity between three nodes that form a triangle, revealed a strong correspondence across web sites, suggestive of an invariant. ...

  2. PIPELINES AS COMMUNICATION NETWORK LINKS

    Energy Technology Data Exchange (ETDEWEB)

    Kelvin T. Erickson; Ann Miller; E. Keith Stanek; C.H. Wu; Shari Dunn-Norman

    2005-03-14

    This report presents the results of an investigation into two methods of using the natural gas pipeline as a communication medium. The work addressed the need to develop secure system monitoring and control techniques between the field and control centers and to robotic devices in the pipeline. In the first method, the pipeline was treated as a microwave waveguide. In the second method, the pipe was treated as a leaky feeder or a multi-ground neutral and the signal was directly injected onto the metal pipe. These methods were tested on existing pipeline loops at UMR and Batelle. The results reported in this report indicate the feasibility of both methods. In addition, a few suitable communication link protocols for this network were analyzed.

  3. X-linked congenital retinoschisis.

    Science.gov (United States)

    Kellner, U; Brümmer, S; Foerster, M H; Wessing, A

    1990-01-01

    The natural history and electrophysiological findings of 52 patients with X-linked congenital retinoschisis with a follow-up of up to 26 years are described. The mean visual acuity was reduced to 0.24 +/- 0.2 and remained unchanged in most patients during this time. If visual loss occurred, it usually happened in the first decennium. The complications were retinal detachments in 11% and vitreous hemorrhages in 4% of the eyes. In general, the vitreous hemorrhages resolved spontaneously. Retinal detachments were treated successfully with conventional buckling procedures. Redetachments occurred in about 40%. Prophylactic laser coagulation was of no use because it was complicated by detachment in 43% of our series. The electro-oculogram was usually normal. In addition to the known electrorentinographic findings of normal a-wave and reduced b-wave amplitudes, we found prolonged b-wave latencies and implicit times, as well as a reduced 30 Hz flicker response.

  4. Linking DC together with TRSL

    DEFF Research Database (Denmark)

    Haxthausen, Anne; Yong, Xia

    1999-01-01

    In this talk we present a method for linking the Duration Calculus together with the Timed RAISE Specification Language. Duration Calculus (DC) [ZHR91] is an interval-based real time logic, which can be used naturally in capturing and eliciting users' real time requirements in the form.......TRSL is a real-time extension of the RAISE Specification Language (RSL) [Rlg92] which together with its associated method [Rmg95]and tools has shown to be very useful in the industrial development of software systems. Therefore, a promising approach for the development of real-time systemscould be to use DC...... of constraints on the durations of states of the system, i.e. at a high level of abstraction.However, as a state-based logic, it lacks the ability to specifysequential programs and communicating concurrent processes at a concrete level. The Timed RAISE Specification Language (TRSL) [XG99] has this ability...

  5. Library links on medical school home pages.

    Science.gov (United States)

    Thomas, Sheila L

    2011-01-01

    The purpose of this study was to assess the websites of American Association of Medical Colleges (AAMC)-member medical schools for the presence of library links. Sixty-one percent (n = 92) of home pages of the 150 member schools of the AAMC contain library links. For the 58 home pages not offering such links, 50 provided a pathway of two or three clicks to a library link. The absence of library links on 39% of AAMC medical school home pages indicates that the designers of those pages did not consider the library to be a primary destination for their visitors.

  6. Adaptive link selection algorithms for distributed estimation

    Science.gov (United States)

    Xu, Songcen; de Lamare, Rodrigo C.; Poor, H. Vincent

    2015-12-01

    This paper presents adaptive link selection algorithms for distributed estimation and considers their application to wireless sensor networks and smart grids. In particular, exhaustive search-based least mean squares (LMS) / recursive least squares (RLS) link selection algorithms and sparsity-inspired LMS / RLS link selection algorithms that can exploit the topology of networks with poor-quality links are considered. The proposed link selection algorithms are then analyzed in terms of their stability, steady-state, and tracking performance and computational complexity. In comparison with the existing centralized or distributed estimation strategies, the key features of the proposed algorithms are as follows: (1) more accurate estimates and faster convergence speed can be obtained and (2) the network is equipped with the ability of link selection that can circumvent link failures and improve the estimation performance. The performance of the proposed algorithms for distributed estimation is illustrated via simulations in applications of wireless sensor networks and smart grids.

  7. Hacking 360 Link: A hybrid approach

    Directory of Open Access Journals (Sweden)

    John Durno

    2012-10-01

    Full Text Available When the University of Victoria Libraries switched from a locally-hosted link resolver (SFX to a vendor-hosted link resolver (360Link, new strategies were required to effectively integrate the vendor-hosted link resolver with the Libraries' other systems and services. Custom javascript is used to add links to the 360Link page; these links then point at local PHP code running on UVic servers, which can then redirect to appropriate local service or display a form directly. An open source PHP OpenURL parser class is announced. Consideration is given to the importance of maintaining open protocols and standards in the transition to vendor-hosted services.

  8. Materializing the web of linked data

    CERN Document Server

    Konstantinou, Nikolaos

    2015-01-01

    This book explains the Linked Data domain by adopting a bottom-up approach: it introduces the fundamental Semantic Web technologies and building blocks, which are then combined into methodologies and end-to-end examples for publishing datasets as Linked Data, and use cases that harness scholarly information and sensor data. It presents how Linked Data is used for web-scale data integration, information management and search. Special emphasis is given to the publication of Linked Data from relational databases as well as from real-time sensor data streams. The authors also trace the transformation from the document-based World Wide Web into a Web of Data. Materializing the Web of Linked Data is addressed to researchers and professionals studying software technologies, tools and approaches that drive the Linked Data ecosystem, and the Web in general.

  9. Community Detection Based on Link Prediction Methods

    CERN Document Server

    Cheng, Hui-Min

    2016-01-01

    Community detection and link prediction are both of great significance in network analysis, which provide very valuable insights into topological structures of the network from diffrent perspectives. In this paper, we propose a novel community detection algorithm with inclusion of link prediction, motivated by the question whether link prediction can be devoted to improve the accuracy of community partition. For link prediction, we propose two novel indices to compute the similarity between each pair of nodes, one of which aims to add missing links, and the other tries to remove spurious edges. Extensive experiments are conducted on benchmark data sets, and the results of our proposed algorithm are compared with two classes of baselines. In conclusion, our proposed algorithm is competitive, revealing that link prediction does improve the precision of community detection.

  10. Remarks on Legendrian Self-Linking

    CERN Document Server

    Beasley, Chris; Zhang, Ruoran

    2015-01-01

    The Thurston-Bennequin invariant provides one notion of self-linking for any homologically-trivial Legendrian curve in a contact three-manifold. Here we discuss related analytic notions of self-linking for Legendrian knots in Euclidean space. Our definition is based upon a reformulation of the elementary Gauss linking integral and is motivated by ideas from supersymmetric gauge theory. We recover the Thurston-Bennequin invariant as a special case.

  11. micromap: A Package for Linked Micromaps

    OpenAIRE

    Quinn C. Payton; Michael G. McManus; Weber, Marc H.; Anthony R. Olsen; Thomas M. Kincaid

    2015-01-01

    The R package micromap is used to create linked micromaps, which display statistical summaries associated with areal units, or polygons. Linked micromaps provide a means to simultaneously summarize and display both statistical and geographic distributions by linking statistical summaries to a series of small maps. The package contains functions dependent on the ggplot2 package to produce a row-oriented graph composed of different panels, or columns, of information. These panels at a minimum t...

  12. Fast Link Adaptation for MIMO-OFDM

    DEFF Research Database (Denmark)

    Jensen, Tobias Lindstrøm; Kant, Shashi; Wehinger, Joachim;

    2010-01-01

    We investigate link-quality metrics (LQMs) based on raw bit-error-rate, effective signal-to-interference-plus-noise ratio, and mutual information (MI) for the purpose of fast link adaptation (LA) in communication systems employing orthogonal frequency-division multiplexing and multiple-input–mult......We investigate link-quality metrics (LQMs) based on raw bit-error-rate, effective signal-to-interference-plus-noise ratio, and mutual information (MI) for the purpose of fast link adaptation (LA) in communication systems employing orthogonal frequency-division multiplexing and multiple...

  13. micromap: A Package for Linked Micromaps

    Directory of Open Access Journals (Sweden)

    Quinn C. Payton

    2015-02-01

    Full Text Available The R package micromap is used to create linked micromaps, which display statistical summaries associated with areal units, or polygons. Linked micromaps provide a means to simultaneously summarize and display both statistical and geographic distributions by linking statistical summaries to a series of small maps. The package contains functions dependent on the ggplot2 package to produce a row-oriented graph composed of different panels, or columns, of information. These panels at a minimum typically contain maps, a legend, and statistical summaries, with the color-coded legend linking the maps and statistical summaries. We first describe the layout of linked micromaps and then the structure required for both the spatial and statistical datasets. The function create_map_table in the micromap package converts the input of an sp SpatialPolygonsDataFrame into a data frame that can be linked with the statistical dataset. Highly detailed polygons are not appropriate for display in linked micromaps so we describe how polygon boundaries can be simplified, decreasing the time required to draw the graphs, while retaining adequate detail for detection of spatial patterns. Our worked examples of linked micromaps use public health data as well as environmental data collected from spatially balanced probabilistic surveys.

  14. Chemical cross-linking of Chlamydia trachomatis

    DEFF Research Database (Denmark)

    Birkelund, Svend; Lundemose, AG; Christiansen, Gunna

    1988-01-01

    Purified elementary bodies (EBs) of Chlamydia trachomatis serovar L2 were analyzed by chemical cross-linking with disuccinimidyl selenodipropionate. The effect of the cross-linking was analyzed by immunoblotting sodium dodecyl sulfate-polyacrylamide gel electrophoresis-separated components which...

  15. Link-Net : improving railcar fleet management

    Energy Technology Data Exchange (ETDEWEB)

    Mancini, G.; Partington, M. [Procor Limited, Oakville, ON (Canada)

    1997-12-31

    Information about Link-Net, a new rail car information facility available on Netscape, was presented. Link-Net was developed by Ontario`s Procor Limited. It can be used to find a comprehensive list of data on rail fleet management, down to details about the status of single cars. 6 figs.

  16. Glue: Linked data visualizations across multiple files

    Science.gov (United States)

    Beaumont, Chris; Robitaille, Thomas; Borkin, Michelle

    2014-02-01

    Glue, written in Python, links visualizations of scientific datasets across many files, allowing for interactive, linked statistical graphics of multiple files. It supports many file formats including common image formats (jpg, tiff, png), ASCII tables, astronomical image and table formats (FITS, VOT, IPAC), and HDF5. Custom data loaders can also be easily added. Glue is highly scriptable and extendable.

  17. Exploring the obesity-asthma link

    DEFF Research Database (Denmark)

    Fenger, R V; Gonzalez-Quintela, A; Vidal, C;

    2012-01-01

    Obesity and risk of asthma are linked. Different distributions of adiposity, such as visceral, subcutaneous or ectopic adiposity, may affect asthma risk differently.......Obesity and risk of asthma are linked. Different distributions of adiposity, such as visceral, subcutaneous or ectopic adiposity, may affect asthma risk differently....

  18. Link prediction via generalized coupled tensor factorisation

    DEFF Research Database (Denmark)

    Ermiş, Beyza; Evrim, Acar Ataman; Taylan Cemgil, A.

    2012-01-01

    This study deals with the missing link prediction problem: the problem of predicting the existence of missing connections between entities of interest. We address link prediction using coupled analysis of relational datasets represented as heterogeneous data, i.e., datasets in the form of matrice...

  19. Wireless link design using a patch antenna

    Energy Technology Data Exchange (ETDEWEB)

    Hall, E

    2000-08-11

    A wireless link was designed using a patch antenna. In the process, several different models were tested. Testing proved a patch antenna was a viable solution for building a wireless link within the design specifications. Also, this experimentation provided a basis for future patch antenna design.

  20. Propagation engineering in radio links design

    CERN Document Server

    Ghasemi, Abdollah; Ghasemi, Farshid

    2013-01-01

    Propagation Engineering in Radio Link Design covers the basic principles of radiowaves propagation in a practical manner.  This fundamental understanding enables the readers to design radio links efficiently. This book elaborates on new achievements as well as recently developed propagation models.  This is in addition to a comprehensive overview of fundamentals of propagation in various scenarios. It examines theoretical calculations, approaches and applied procedures needed for radio links design. The authors study and analysis of the main propagation phenomena and its mechanisms based on the recommendations of International Telecommunications Union, (ITU). The book has been organized in 9 chapters and examines the role of antennas and passive reflectors in radio services, propagation mechanisms related to radar, satellite, short distance, broadcasting and trans-horizon radio links, with two chapters devoted to radio noise and main  parameters of radio link design. The book presents some 278 illustration...

  1. A generalized theory of preferential linking

    CERN Document Server

    Hu, Haibo; Liu, Xuan

    2013-01-01

    There are diverse mechanisms driving the evolution of social networks. A key open question dealing with understanding their evolution is: How various preferential linking mechanisms produce networks with different features? In this paper we first empirically study preferential linking phenomena in an evolving online social network, find and validate the linear preference. We propose an analyzable model which captures the real growth process of the network and reveals the underlying mechanism dominating its evolution. Furthermore based on preferential linking we propose a generalized model reproducing the evolution of online social networks, present unified analytical results describing network characteristics for 27 preference scenarios, and explore the relation between preferential linking mechanism and network features. We find that within the framework of preferential linking analytical degree distributions can only be the combinations of finite kinds of functions which are related to rational, logarithmic...

  2. Ubiquitousness of link-density and link-pattern communities in real-world networks

    CERN Document Server

    Šubelj, Lovro

    2011-01-01

    Community structure appears to be an intrinsic property of many complex real-world networks. However, recent work shows that real-world networks reveal even more sophisticated modules than classical cohesive (link-density) communities. In particular, networks can also be naturally partitioned according to similar patterns of connectedness between the nodes, revealing link-pattern communities. We here propose a balanced propagation based algorithm that can extract both link-density and link-pattern communities, without any prior knowledge of the true structure. The algorithm was first validated on different classes of synthetic benchmark networks with community structure, and also on random networks. We have then further applied the algorithm to different social, information, technological and biological networks, where it indeed reveals meaningful (composites of) link-density and link-pattern communities. The results thus seem to imply that, similarly as link-density counterparts, link-pattern communities app...

  3. Web Applications of Bibliometrics and Link Analysis

    Directory of Open Access Journals (Sweden)

    Faribourz Droudi

    2010-04-01

    Full Text Available The present study aims to introduce and analyze bibliometric application within Web and also to expounds on the status of link analysis in order to point out its application with respect to the existing web-based information sources. Findings indicate that bibliometrics could have required application in the area of digital resources available through Net. Link analysis is a process by which one could make statistical analysis of correlation between hyperlinks and therefore understand the accuracy, veracity and efficacy of citations within a digital document. Link analysis, in effect, is counted as a part of information ranking algorithm within the web environment. The number, linkage and quality of given links to a website are of utmost importance for ranking/status in the Web. The tools applied in this topic include, page ranking strategy, link analysis algorithm, latent semantic indexing and the classical input-output model. The present study analyzes Big Web and Small Web link analysis and explains the means for utilizing web charts in order to better understand the link analysis process.

  4. Predicting Anchor Links between Heterogeneous Social Networks

    CERN Document Server

    Sajadmanesh, Sina; Khodadadi, Ali

    2016-01-01

    People usually get involved in multiple social networks to enjoy new services or to fulfill their needs. Many new social networks try to attract users of other existing networks to increase the number of their users. Once a user (called source user) of a social network (called source network) joins a new social network (called target network), a new inter-network link (called anchor link) is formed between the source and target networks. In this paper, we concentrated on predicting the formation of such anchor links between heterogeneous social networks. Unlike conventional link prediction problems in which the formation of a link between two existing users within a single network is predicted, in anchor link prediction, the target user is missing and will be added to the target network once the anchor link is created. To solve this problem, we use meta-paths as a powerful tool for utilizing heterogeneous information in both the source and target networks. To this end, we propose an effective general meta-pat...

  5. Link Characteristics and Forecast for Internet Users

    Institute of Scientific and Technical Information of China (English)

    JINZhigang; LUOYongmei

    2004-01-01

    For a user sharing Internet resources the “Weather Forecast” of the Internet is important. As a user, he has no right to access the status of routers/switches and has not enough information about the overall network. In order to give users useful information and the forecast, this paper proposes a new approach to measure and forecast Internet link status and Local area network (LAN) traffic. In this paper, the design and implementation of a user-oriented, generalized system are proposed for characterizing the links and producing short-term performance forecasts based on historical link characteristics. Pathchar, packet pair are used to measure the latency of hops along a link, and TCPdump is used to collect the traffic of the local LAN. When using these measurement tools in appropriate time scales, we can set up a set of indicators for link status and do prediction for the link characteristics in the future. To improve the accuracy of the estimate of bandwidth, the Extreme value theory (EVT) is deployed. The experimental data show the feasibility of EVT filters. The data show that the EVT resuits are more close to nominal bandwidth. The FARIMA (p,d,q) (fractional autoregressive integrated moving average) based prediction is also presented to forecast the furure status of links and the local traffic.

  6. Linked-OWL : A new approach for dynamic linked data service workflow composition

    OpenAIRE

    Hussien Ahmad; Salah Dowaji

    2013-01-01

    The shift from Web of Document into Web of Data based on Linked Data principles defined by Tim Berners-Lee posed a big challenge to build and develop applications to work in Web of Data environment. There are several attempts to build service and application models for Linked Data Cloud. In this paper, we propose a new service model for linked data "Linked-OWL" which is based on RESTful services and OWL-S and copes with linked data principles. This new model shifts the service concept from fu...

  7. Markkinointiviestintä Linked By Music Oy

    OpenAIRE

    Makkonen, Joonas; Kairamo, Teemu

    2014-01-01

    Tämän opinnäytetyön aiheena oli Markkinointiviestintäsuunnitelma aloittelevalle Linked by Music Oy:lle. Opinnäytetyön tavoite oli luoda toimiva ja pienenbudjetin markkinointiviestintäsuunnitelma Linked by Musicin lanseerauksen ympärille. Erityisenä haasteena olikin rakentaa markkinointiviestintäsuunnitelmasta tehokas ilman, että siihen käytetään paljon rahaa. Linked by Musicia ei ole vielä lanseerattu, joten markkinointiviestintäsuunnitelma keskittyi lanseerauksen ympärille ja ensimmäisille ...

  8. Novel fat-link fermion actions

    CERN Document Server

    Zanotti, J M; Bonnet, F D R; Coddington, P D; Leinweber, D B; Williams, A G; Zhang, J B; Melnitchouk, W; Lee, F X

    2002-01-01

    The hadron mass spectrum is calculated in lattice QCD using a novel fat-link clover fermion action in which only the irrelevant operators of the fermion action are constructed using smeared links. The simulations are performed on a 16^3 X 32 lattice with a lattice spacing of a=0.125 fm. We compare actions with n=4 and 12 smearing sweeps with a smearing fraction of 0.7. The n=4 Fat Link Irrelevant Clover (FLIC) action provides scaling which is superior to mean-field improvement, and offers advantages over nonperturbative O(a) improvement.

  9. External Link Policy | Division of Cancer Prevention

    Science.gov (United States)

    The following graphic notice means that you are leaving the DCP Web site: (link is external)This external link provides additional information that is consistent with the intended purpose of DCP.The National Cancer Institute (NCI) cannot attest to the accuracy of a non-federal site.Linking to a non-federal site does not constitute an endorsement by HHS or any of its employees of the sponsors or the information and products presented on the site.You will be subject to the destination site |

  10. Mobile Recommendation Based on Link Community Detection

    Directory of Open Access Journals (Sweden)

    Kun Deng

    2014-01-01

    Full Text Available Since traditional mobile recommendation systems have difficulty in acquiring complete and accurate user information in mobile networks, the accuracy of recommendation is not high. In order to solve this problem, this paper proposes a novel mobile recommendation algorithm based on link community detection (MRLD. MRLD executes link label diffusion algorithm and maximal extended modularity (EQ of greedy search to obtain the link community structure, and overlapping nodes belonging analysis (ONBA is adopted to adjust the overlapping nodes in order to get the more accurate community structure. MRLD is tested on both synthetic and real-world networks, and the experimental results show that our approach is valid and feasible.

  11. Link prediction in complex networks: A survey

    Science.gov (United States)

    Lü, Linyuan; Zhou, Tao

    2011-03-01

    Link prediction in complex networks has attracted increasing attention from both physical and computer science communities. The algorithms can be used to extract missing information, identify spurious interactions, evaluate network evolving mechanisms, and so on. This article summaries recent progress about link prediction algorithms, emphasizing on the contributions from physical perspectives and approaches, such as the random-walk-based methods and the maximum likelihood methods. We also introduce three typical applications: reconstruction of networks, evaluation of network evolving mechanism and classification of partially labeled networks. Finally, we introduce some applications and outline future challenges of link prediction algorithms.

  12. The Gigabit Link Interface Board (GLIB) ecosystem

    CERN Document Server

    Vichoudis, P; Baron, S; Barros Marin, M; Bobillier, V; Chramowitz, J; Haas, S; Hansen, M; Joos, M; Lobato Pardavila, L; Petit, P; Prosser, A; Vasey, F

    2013-01-01

    The Gigabit Link Interface Board (GLIB) project is an FPGA-based platform for users of high-speed optical links in high energy physics experiments. The major hardware component of the platform is the GLIB Advanced Mezzanine Card (AMC). Additionally to the AMC, auxiliary components are developed that enhance GLIB platform's I/O bandwidth and compatibility with legacy and future triggering and/or data acquisition interfaces. This article focuses on the development of the auxiliary components that together with the GLIB AMC offer a complete solution for beam/irradiation tests of detector modules and evaluation of optical links.

  13. Link mining models, algorithms, and applications

    CERN Document Server

    Yu, Philip S; Faloutsos, Christos

    2010-01-01

    This book presents in-depth surveys and systematic discussions on models, algorithms and applications for link mining. Link mining is an important field of data mining. Traditional data mining focuses on 'flat' data in which each data object is represented as a fixed-length attribute vector. However, many real-world data sets are much richer in structure, involving objects of multiple types that are related to each other. Hence, recently link mining has become an emerging field of data mining, which has a high impact in various important applications such as text mining, social network analysi

  14. Field experience with optical data links

    International Nuclear Information System (INIS)

    A previous report on a high performance dc to 1 MHz analog fiber-optic telemetry link was developed especially for the neutral beam power supplies on the Tokamak Fusion Test Reactor (TFTR). This paper describes the field experience with that link. The field operation of the optical data links began in late 1983. The performance of this system as found to be exemplary. The testing of the overall neutral beam system was accelerated by the introduction of this specially developed electronics. The accuracy and stability of the telemetry, coupled with the remote calibration feature enabled the neutral beam system operators to concentrate on the development of the neutral beam system

  15. Linked-OWL: A new approach for dynamic linked data service workflow composition

    Directory of Open Access Journals (Sweden)

    Hussien Ahmad

    2013-06-01

    Full Text Available The shift from Web of Document into Web of Data based on Linked Data principles defined by Tim Berners-Lee posed a big challenge to build and develop applications to work in Web of Data environment. There are several attempts to build service and application models for Linked Data Cloud. In this paper, we propose a new service model for linked data "Linked-OWL" which is based on RESTful services and OWL-S and copes with linked data principles. This new model shifts the service concept from functions into linked data things and opens the road for Linked Oriented Architecture (LOA and Web of Services as part and on top of Web of Data. This model also provides high level of dynamic service composition capabilities for more accurate dynamic composition and execution of complex business processes in Web of Data environment.

  16. Using Linked Data in Learning Analytics

    NARCIS (Netherlands)

    d'Aquin, Mathieu; Dietze, Stefan; Drachsler, Hendrik; Herder, Eelco

    2013-01-01

    d'Aquin, M., Dietze, S., Drachsler, H., & Herder, E. (2013, April). Using Linked Data in Learning Analytics. Tutorial given at LAK 2013, the Third Conference on Learning Analytics and Knowledge, Leuven, Belgium.

  17. Predicting missing links via correlation between nodes

    CERN Document Server

    Liao, Hao; Zhang, Yi-Cheng

    2014-01-01

    As a fundamental problem in many different fields, link prediction aims to estimate the likelihood of an existing link between two nodes based on the observed information. Since this problem is related to many applications ranging from uncovering missing data to predicting the evolution of networks, link prediction has been intensively investigated recently and many methods have been proposed so far. The essential challenge of link prediction is to estimate the similarity between nodes. Most of the existing methods are based on the common neighbor index and its variants. In this paper, we propose to calculate the similarity between nodes by the correlation coefficient. This method is found to be very effective when applied to calculate similarity based on high order paths. We finally fuse the correlation-based method with the resource allocation method, and find that the combined method can substantially outperform the existing methods, especially in sparse networks.

  18. Pesticides Linked to Raised Risk of ALS

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_158737.html Pesticides Linked to Raised Risk of ALS One toxin ... MONDAY, May 9, 2016 (HealthDay News) -- Exposure to pesticides and other chemicals may increase the risk for ...

  19. Mercury Poisoning Linked to Skin Products

    Science.gov (United States)

    ... Products For Consumers Home For Consumers Consumer Updates Mercury Poisoning Linked to Skin Products Share Tweet Linkedin ... situations, criminal prosecution. back to top Dangers of Mercury Exposure to mercury can have serious health consequences. ...

  20. Linking Medicare, Medicaid, and Cancer Registry Data...

    Data.gov (United States)

    U.S. Department of Health & Human Services — Linking Medicare, Medicaid, and Cancer Registry Data to Study the Burden of Cancers in West Virginia In the United States, the elderly carry an unequal burden of...

  1. The links between science and industrialization

    OpenAIRE

    Dugan, David

    2004-01-01

    Simon Schaffer explains the links between science and industrialization. He explains the history of the Royal Institution where he is standing and the research into agriculture and chemistry which was so important.

  2. Gallstones Linked to Higher Heart Disease Risk

    Science.gov (United States)

    ... news/fullstory_160497.html Gallstones Linked to Higher Heart Disease Risk Researcher says study highlights a connection between ... may have a slightly increased risk of developing heart disease down the road, a large new study suggests. ...

  3. More Evidence Linking Obesity to Liver Cancer

    Science.gov (United States)

    ... fullstory_161494.html More Evidence Linking Obesity to Liver Cancer And type 2 diabetes more than doubles the ... type 2 diabetes, may raise your risk for liver cancer, a new study suggests. "We found that each ...

  4. Broadcasting satellite feeder links - Characteristics and planning

    Science.gov (United States)

    Kiebler, J. W.

    1982-01-01

    The paper presents the results of recent studies by the Feeder Link Sub-Working Group of the FCC Advisory Committee for the 1983 Regional Administrative Radio Conference (RARC). These studies conclude that specification of a few key parameters will make feeder link planning relatively straightforward. Feeder links can be located anywhere within a country if satellite orbit locations are separated by 10 deg for adjacent service areas and key parameter values presented in the paper are adopted. Colocated satellites serving a common service area need special attention to attain sufficient isolation between a desired channel and its adjacent cross-polarized channels and alternate co-polarized channels. In addition to presenting planning conclusions by the Advisory Committee, the paper presents and analyzes actions of the International Radio Consultative Committee's Conference Planning Meeting (CPM) concerning feeder links. The CPM reached conclusions similar to, and compatible with, those of the Advisory Committee.

  5. Cellular Defect May Be Linked to Parkinson's

    Science.gov (United States)

    ... 160862.html Cellular Defect May Be Linked to Parkinson's: Study Abnormality might apply to all forms of ... that may be common to all forms of Parkinson's disease. The defect plays a major role in ...

  6. Pesticides Linked to Raised Risk of ALS

    Science.gov (United States)

    ... nlm.nih.gov/medlineplus/news/fullstory_158737.html Pesticides Linked to Raised Risk of ALS One toxin ... MONDAY, May 9, 2016 (HealthDay News) -- Exposure to pesticides and other chemicals may increase the risk for ...

  7. Five New Genes Linked to Colon Cancer

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_159556.html Five New Genes Linked to Colon Cancer But researchers say it's ... 2016 (HealthDay News) -- Scientists have identified five new gene mutations that may be tied to colon cancer. ...

  8. Gut Microbes Linked to Rheumatoid Arthritis

    Science.gov (United States)

    ... ask if this is indeed the case.” — by Carol Torgan, Ph.D. Related Links Feeling Out of ... Assistant Editors: Vicki Contie, Tianna Hicklin, Ph.D., Carol Torgan, Ph.D. NIH Research Matters is a ...

  9. Hormone May Be Linked to Teenage Obesity

    Science.gov (United States)

    ... 159014.html Hormone May Be Linked to Teenage Obesity Researchers suspect low levels of spexin might play ... reduced levels of this hormone in adults with obesity. Overall, our findings suggest spexin may play a ...

  10. A Robust Parsing Algorithm For Link Grammars

    CERN Document Server

    Grinberg, D; Sleator, D; Grinberg, Dennis; Lafferty, John; Sleator, Daniel

    1995-01-01

    In this paper we present a robust parsing algorithm based on the link grammar formalism for parsing natural languages. Our algorithm is a natural extension of the original dynamic programming recognition algorithm which recursively counts the number of linkages between two words in the input sentence. The modified algorithm uses the notion of a null link in order to allow a connection between any pair of adjacent words, regardless of their dictionary definitions. The algorithm proceeds by making three dynamic programming passes. In the first pass, the input is parsed using the original algorithm which enforces the constraints on links to ensure grammaticality. In the second pass, the total cost of each substring of words is computed, where cost is determined by the number of null links necessary to parse the substring. The final pass counts the total number of parses with minimal cost. All of the original pruning techniques have natural counterparts in the robust algorithm. When used together with memoization...

  11. Bounded link prediction for very large networks

    CERN Document Server

    Cui, Wei; Xu, Zhongqi

    2015-01-01

    Evaluation of link prediction methods is a hard task in very large complex networks because of the inhibitive computational cost. By setting a lower bound of the number of common neighbors (CN), we propose a new framework to efficiently and precisely evaluate the performances of CN-based similarity indices in link prediction for very large heterogeneous networks. Specifically, we propose a fast algorithm based on the parallel computing scheme to obtain all the node pairs with CN values larger than the lower bound. Furthermore, we propose a new measurement, called self-predictability, to quantify the performance of the CN-based similarity indices in link prediction, which on the other side can indicate the link predictability of a network.

  12. Predicting missing links via correlation between nodes

    Science.gov (United States)

    Liao, Hao; Zeng, An; Zhang, Yi-Cheng

    2015-10-01

    As a fundamental problem in many different fields, link prediction aims to estimate the likelihood of an existing link between two nodes based on the observed information. Since this problem is related to many applications ranging from uncovering missing data to predicting the evolution of networks, link prediction has been intensively investigated recently and many methods have been proposed so far. The essential challenge of link prediction is to estimate the similarity between nodes. Most of the existing methods are based on the common neighbor index and its variants. In this paper, we propose to calculate the similarity between nodes by the Pearson correlation coefficient. This method is found to be very effective when applied to calculate similarity based on high order paths. We finally fuse the correlation-based method with the resource allocation method, and find that the combined method can substantially outperform the existing methods, especially in sparse networks.

  13. Bounded link prediction in very large networks

    Science.gov (United States)

    Cui, Wei; Pu, Cunlai; Xu, Zhongqi; Cai, Shimin; Yang, Jian; Michaelson, Andrew

    2016-09-01

    Evaluating link prediction methods is a hard task in very large complex networks due to the prohibitive computational cost. However, if we consider the lower bound of node pairs' similarity scores, this task can be greatly optimized. In this paper, we study CN index in the bounded link prediction framework, which is applicable to enormous heterogeneous networks. Specifically, we propose a fast algorithm based on the parallel computing scheme to obtain all node pairs with CN values larger than the lower bound. Furthermore, we propose a general measurement, called self-predictability, to quantify the performance of similarity indices in link prediction, which can also indicate the link predictability of networks with respect to given similarity indices.

  14. Network error correction with unequal link capacities

    CERN Document Server

    Kim, Sukwon; Effros, Michelle; Avestimehr, Amir Salman

    2010-01-01

    This paper studies the capacity of single-source single-sink noiseless networks under adversarial or arbitrary errors on no more than z edges. Unlike prior papers, which assume equal capacities on all links, arbitrary link capacities are considered. Results include new upper bounds, network error correction coding strategies, and examples of network families where our bounds are tight. An example is provided of a network where the capacity is 50% greater than the best rate that can be achieved with linear coding. While coding at the source and sink suffices in networks with equal link capacities, in networks with unequal link capacities, it is shown that intermediate nodes may have to do coding, nonlinear error detection, or error correction in order to achieve the network error correction capacity.

  15. Hormone May Be Linked to Teenage Obesity

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_159014.html Hormone May Be Linked to Teenage Obesity Researchers suspect ... may have lower levels of a weight-regulating hormone than normal-weight teens, a new study says. " ...

  16. Prenatal Inflammation Linked to Autism Risk

    Science.gov (United States)

    ... Thursday, January 24, 2013 Prenatal inflammation linked to autism risk Maternal inflammation during early pregnancy may be related to an increased risk of autism in children, according to new findings supported by ...

  17. Development Issues on Linked Data Weblog Enrichment

    Science.gov (United States)

    Ruiz-Rube, Iván; Cornejo, Carlos M.; Dodero, Juan Manuel; García, Vicente M.

    In this paper, we describe the issues found during the development of LinkedBlog, a Linked Data extension for WordPress blogs. This extension enables to enrich text-based and video information contained in blog entries with RDF triples that are suitable to be stored, managed and exploited by other web-based applications. The issues have to do with the generality, usability, tracking, depth, security, trustiness and performance of the linked data enrichment process. The presented annotation approach aims at maintaining web-based contents independent from the underlying ontological model, by providing a loosely coupled RDFa-based approach in the linked data application. Finally, we detail how the performance of annotations can be improved through a semantic reasoner.

  18. Early Alzheimer's Linked to Brain 'Leakage'

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_159116.html Early Alzheimer's Linked to Brain 'Leakage' Normally, blood-brain barrier ... HealthDay News) -- People in the early stages of Alzheimer's disease may have more "leaks" in the barrier ...

  19. Energy: The Link between GDP and Emissions

    OpenAIRE

    Jan-Erik Lane

    2013-01-01

    The global energy-environment conundrum unfolds now with more and more evidence confirming the climate change hypothesis. The accumulation of greenhouses gases in the atmosphere is strongly linked with economic production, the GDP indicator. Here we give the exact relationships between GDP, energy consumption and greenhouse gases emissions, over time and cross-sectionally for the entire globe. The intermediating link between total GDP and total emissions is, it must be emphasized, the energy ...

  20. GDP-linked bonds and sovereign default

    OpenAIRE

    Barr, David; Bush, Oliver; Pienkowski, Alex

    2014-01-01

    Using a calibrated model of endogenous sovereign default, we explore how GDP-linked bonds can raise the maximum sustainable debt level of a government, and substantially reduce the incidence of default. The model explores both the costs (in particular the GDP risk premium) and the benefits of issuing GDP-linked bonds. It concludes that significant welfare gains can be achieved by indexing debt to GDP.

  1. Microwaves photonic links components and circuits

    CERN Document Server

    Rumelhard, Christian; Billabert, Anne-Laure

    2013-01-01

    This book presents the electrical models for the different elements of a photonic microwave link like lasers, external modulators, optical fibers, photodiodes and phototransistors. The future trends of these components are also introduced: lasers to VCSEL, external modulators to electro-absorption modulators, glass optical fibers to plastic optical fibers, photodiodes to UTC photodiodes or phototransistors. It also describes an original methodology to evaluate the performance of a microwave photonic link, based on the developed elcetrical models, that can be easily incorporated in

  2. Cross-modal links in spatial attention.

    OpenAIRE

    Driver, J; Spence, C.

    1998-01-01

    A great deal is now known about the effects of spatial attention within individual sensory modalities, especially for vision and audition. However, there has been little previous study of possible cross-modal links in attention. Here, we review recent findings from our own experiments on this topic, which reveal extensive spatial links between the modalities. An irrelevant but salient event presented within touch, audition, or vision, can attract covert spatial attention in the other modaliti...

  3. Legendrian framings for two-bridge links

    CERN Document Server

    Baader, Sebastian

    2009-01-01

    We define the Thurston-Bennequin polytope of a two-component link as the convex hull of all pairs of integers that arise as framings of a Legendrian representative. The main result of this paper is a description of the Thurston-Bennequin polytope for two-bridge links. As an application, we construct non-quasipositive surfaces in $\\R^3$ all whose sub-annuli are quasipositive.

  4. Star repeaters for fiber optic links.

    Science.gov (United States)

    McMahon, D H; Gravel, R L

    1977-02-01

    A star repeater combines the functions of a passive star coupler and a signal regenerating amplifier. By more effectively utilizing the light power radiated by a light emitting diode, the star repeater can, when used with small diameter channels, couple as much power to all receivers of a multiterminal link as would be coupled to the single receiver of a simple point-to-point link.

  5. Negative Link Prediction in Social Media

    OpenAIRE

    Tang, Jiliang; Chang, Shiyu; Aggarwal, Charu; Liu, Huan

    2014-01-01

    Signed network analysis has attracted increasing attention in recent years. This is in part because research on signed network analysis suggests that negative links have added value in the analytical process. A major impediment in their effective use is that most social media sites do not enable users to specify them explicitly. In other words, a gap exists between the importance of negative links and their availability in real data sets. Therefore, it is natural to explore whether one can pr...

  6. A Robust Parsing Algorithm For Link Grammars

    OpenAIRE

    Grinberg, Dennis; Lafferty, John; Sleator, Daniel

    1995-01-01

    In this paper we present a robust parsing algorithm based on the link grammar formalism for parsing natural languages. Our algorithm is a natural extension of the original dynamic programming recognition algorithm which recursively counts the number of linkages between two words in the input sentence. The modified algorithm uses the notion of a null link in order to allow a connection between any pair of adjacent words, regardless of their dictionary definitions. The algorithm proceeds by mak...

  7. Quantum group invariants and link polynomials

    International Nuclear Information System (INIS)

    A general method is developed for constructing quantum group invariants and determining their eigenvalues. Applied to the universal R-matrix this method leads to the construction of a closed formula for link polynomials. To illustrate the application of this formula, the quantum groups Uq(E8), Uq(so(2m+1)) and Uq(gl(m)) are considered as examples, and corresponding link polynomials are obtained. (orig.)

  8. Catenanes: Fifty Years of Molecular Links

    OpenAIRE

    Gil-Ramírez, Guzmán; Leigh, David A.; Stephens, Alexander J.

    2015-01-01

    Half a century after Schill and Lüttringhaus carried out the first directed synthesis of a [2]catenane, a plethora of strategies now exist for the construction of molecular Hopf links (singly interlocked rings), the simplest type of catenane. The precision and effectiveness with which suitable templates and/or noncovalent interactions can arrange building blocks has also enabled the synthesis of intricate and often beautiful higher order interlocked systems, including Solomon links, Borromean...

  9. Augmenting SCORM Manifests with Adaptive Links

    OpenAIRE

    Abdullah, NA; Bailey, CP; Davis, HC

    2004-01-01

    This paper describes an experiment to augment SCORM manifests with adaptive links using AuldLinky in order to promote content reusability, interoperability and personalized e-learning. Our technique involves the automatic deduction of a concept map from a manifest and the transformation of its pertinent elements into FOHM (Fundamental Object Hypermedia Model) objects before augmenting the information with complimentary and adaptive links using AuldLinky.

  10. Disease : the link between geochemistry and health

    OpenAIRE

    Fordyce, Fiona; Smith, Barry

    1997-01-01

    Many minerals that are essential to human health in small doses can be toxic if ingested in excess. These minerals enter the human population via the plants, animals and water that make up our food supply and through the ingestion and inhalation of dusts derived from our living environment. Animals and plants depend ultimately on soil, water and rock for the provision of minerals hence the link between geochemistry and health. This link is particularly important in developing countries where ...

  11. Hodge-type structures as link invariants

    OpenAIRE

    Borodzik, Maciej; Nemethi, Andras

    2010-01-01

    Based on some analogies with the Hodge theory of isolated hypersurface singularities, we define Hodge-type numerical invariants (called H-numbers) of any, not necessarily algebraic, link in $S^3$. They contain the same information as the (normalized) real Seifert matrix. We study their basic properties, we express the Tristram-Levine signatures and the higher order Alexander polynomial in terms of them. Motivated by singularity theory, we also introduce the spectrum of the link (determined fr...

  12. Link Graph Analysis for Adult Images Classification

    OpenAIRE

    Kharitonov, E.; Slesarev, A.; Muchnik, I.; Romanenko, F.; Belyaev, D.; Kotlyarov, D.

    2010-01-01

    In order to protect an image search engine’s users from undesirable results adult images’ classifier should be built. The information about links from websites to images is employed to create such a classifier. These links are represented as a bipartite website-image graph. Each vertex is equipped with scores of adultness and decentness. The scores for image vertexes are initialized with zero, those for website vertexes are initialized according to a text-based website classifier. An iterativ...

  13. Linking Ergonomics with the Human Resources Management

    OpenAIRE

    Aurel MANOLESCU; Ion VERBONCU; Victor LEFTER; Cristian MARINAS

    2010-01-01

    During the last years, ergonomics became one of the reference domains in the managerial theory and practice. Ergonomics is a major component of the human resources management and also, it is an important factor of performances. Ergonomics is the link between efficiency, effectiveness, security and heath and in this context it is necessary to approach the ergonomics and its impact on the process of the organizational development and on the employees. The links between ergonomics and Human Reso...

  14. RF Photonic Technology in Optical Fiber Links

    Science.gov (United States)

    Chang, William S. C.

    2007-06-01

    List of contributors; Introduction and preface; 1. Figures of merit and performance analysis of photonic microwave links Charles Cox and William S. C. Chang; 2. RF subcarrier links in local access networks Xiaolin Lu; 3. Analog modulation of semiconductor lasers Joachim Piprek and John E. Bowers; 4. LiNbO3 external modulators and their use in high performance analog links Gary E. Betts; 5. Broadband traveling wave modulators in LiNbO3 Marta M. Howerton and William K. Burns; 6. Multiple quantum well electroabsorption modulators for RF photonic links William S. C. Chang; 7. Polymer modulators for RF photonics Timothy Van Eck; 8. Photodiodes for high performance analog links P. K. L. Yu and Ming C. Wu; 9. Opto-electronic oscillators X. Steve Yao; 10. Photonic link techniques for microwave frequency conversion Stephen A. Pappert, Roger Helkey and Ronald T. Logan Jr; 11. Antenna-coupled millimeter-wave electro-optical modulators William B. Bridges; 12. System design and performance of wideband photonic phased array antennas Greg L. Tangonan, Willie Ng, Daniel Yap and Ron Stephens; Acknowledgements; References; Index.

  15. Effect of burn injury on relative anaplerosis and gluconeogenesis in rats by 13C magnetic resonance spectrum

    Institute of Scientific and Technical Information of China (English)

    夏照帆; 田建广; 王光毅; 葛绳德; 唐洪泰

    2002-01-01

    Objective: To introduce a safe and specific approachof 13C magnetic resonance spectrum (13C MRS )spectroscopy and investigate the alterations in hepaticanabolism.Methods: Relative anaplerotic, pyruvate recyclingand gluconeogenic fluxes were measured by 13C MRSisotopomer analysis of blood glucose from rats with 40%body surface area burn injury, and from rats exposed tosham injury. A short chain fatty acid, [U-13C] propionatewhich was avidly extracted by the liver, was infusedintravenously to deliver 13C into the citric acid cycle.Proton-decoupled 13C MRS of deproteinized plasma orextracts of the freeze-clamped liver were used to determinethe distribution of 13C in blood or hepatic glucose.Results: There was no difference in the multipletsdetected in the glucose carbon-2 anomer from blood or liverafter 45 or 60 minutes of the infusion of the propionate,indicating that steady-state isotopic conditions wereachieved. Gluconeogenesis relative to citric acid cycle fluxwas not altered by burn injury; in both sham and burngroups the rate of glucose production was about equal toflux through citrate synthase. In the sham group ofanimals, the rate of entry of carbon skeletons into the citricacid cycle was about 4 times than that in the burn group.Similarly, flux through pyruvate kinase (again relative tocitrate synthase) was significantly increased after the burninjury.Conclusions: Since results from analysis of the bloodglucose are the same as that of the hepatic glucose, 13Cdistribution in the glucose and hepatic metabolism can beassessed based on the 13C MRS analysis of the bloodglucose.

  16. Effect of Link Flexibility on tip position of a single link robotic arm

    Science.gov (United States)

    Madhusudan Raju, E.; Siva Rama Krishna, L.; Mouli, Y. Sharath Chandra; Nageswara Rao, V.

    2015-12-01

    The flexible robots are widely used in space applications due to their quick response, lower energy consumption, lower overall mass and operation at high speed compared to conventional industrial rigid link robots. These robots are inherently flexible, so that the kinematics of flexible robots can't be solved with rigid body assumptions. The flexibility in links and joints affects end-point positioning accuracy of the robot. It is important to model the link kinematics with precision which in turn simplifies modelling of dynamics of flexible robots. The main objective of this paper is to evaluate the effect of link flexibility on a tip position of a single link robotic arm for a given motion. The joint is assumed to be rigid and only link flexibility is considered. The kinematics of flexible link problem is evaluated by Assumed Modes Method (AMM) using MAT LAB Programming. To evaluate the effect of link flexibility (with and without payload) of robotic arm, the normalized tip deviation is found for flexible link with respect to a rigid link. Finally, the limiting inertia for payload mass is found if the allowable tip deviation is 5%.

  17. Semantic analysis of links in the musical Wikipedia

    DEFF Research Database (Denmark)

    Mølgaard, Lasse Lohilahti; Hansen, Lars Kai; Larsen, Jan

    2008-01-01

    Wikipedia has significant potential in music information retrieval research. In this work we analyze the of the link structure in the musical Wikipedia. Wikipedia links differ in certain ways from links on the Web at large. There are an over-abundance of internal links in Wikipedia, links...

  18. Publishing Data on Physical Samples Using the GeoLink Ontology and Linked Data Platforms

    Science.gov (United States)

    Ji, P.; Arko, R. A.; Lehnert, K. A.; Song, L.; Carter, M. R.; Hsu, L.

    2015-12-01

    Interdisciplinary Earth Data Alliance (IEDA), one of partners in EarthCube GeoLink project, seeks to explore the extent to which the use of GeoLink reusable Ontology Design Patterns (ODPs) and linked data platforms in IEDA data infrastructure can make research data more easily accessible and valuable. Linked data for the System for Earth Sample Registration (SESAR) is the first effort of IEDA to show how linked data enhance the presentation of IEDA data system architecture. SESAR Linked Data maps each table and column in SESAR database to RDF class and property based on GeoLink view, which build on the top of GeoLink ODPs. Then, uses D2RQ dumping the contents of SESAR database into RDF triples on the basis of mapping results. And, the dumped RDF triples is loaded into GRAPHDB, an RDF graph database, as permanent data in the form of atomic facts expressed as subjects, predicates and objects which provide support for semantic interoperability between IEDA and other GeoLink partners. Finally, an integrated browsing and searching interface build on Callimachus, a highly scalable platform for publishing linked data, is introduced to make sense of data stored in triplestore. Drill down and through features are built in the interface to help users locating content efficiently. The drill down feature enables users to explore beyond the summary information in the instance list of a specific class and into the detail from the specific instance page. The drill through feature enables users to jump from one instance to another one by simply clicking the link of the latter nested in the former region. Additionally, OpenLayers map is embedded into the interface to enhance the attractiveness of the presentation of instance which has geospatial information. Furthermore, by linking instances in the SESAR datasets to matching or corresponding instances in external sets, the presentation has been enriched with additional information about related classes like person, cruise, etc.

  19. Cross-linking chemistry of squid beak.

    Science.gov (United States)

    Miserez, Ali; Rubin, Daniel; Waite, J Herbert

    2010-12-01

    In stark contrast to most aggressive predators, Dosidicus gigas (jumbo squids) do not use minerals in their powerful mouthparts known as beaks. Their beaks instead consist of a highly sclerotized chitinous composite with incremental hydration from the tip to the base. We previously reported l-3,4-dihydroxyphenylalanine (dopa)-histidine (dopa-His) as an important covalent cross-link providing mechanical strengthening to the beak material. Here, we present a more complete characterization of the sclerotization chemistry and describe additional cross-links from D. gigas beak. All cross-links presented in this report share common building blocks, a family of di-, tri-, and tetra-histidine-catecholic adducts, that were separated by affinity chromatography and high performance liquid chromatography (HPLC) and identified by tandem mass spectroscopy and proton nuclear magnetic resonance ((1)H NMR). The data provide additional insights into the unusually high cross-link density found in mature beaks. Furthermore, we propose both a low molecular weight catechol, and peptidyl-dopa, to be sclerotization agents of squid beak. This appears to represent a new strategy for forming hard tissue in animals. The interplay between covalent cross-linking and dehydration on the graded properties of the beaks is discussed. PMID:20870720

  20. Cross-linking Chemistry of Squid Beak*

    Science.gov (United States)

    Miserez, Ali; Rubin, Daniel; Waite, J. Herbert

    2010-01-01

    In stark contrast to most aggressive predators, Dosidicus gigas (jumbo squids) do not use minerals in their powerful mouthparts known as beaks. Their beaks instead consist of a highly sclerotized chitinous composite with incremental hydration from the tip to the base. We previously reported l-3,4-dihydroxyphenylalanine (dopa)-histidine (dopa-His) as an important covalent cross-link providing mechanical strengthening to the beak material. Here, we present a more complete characterization of the sclerotization chemistry and describe additional cross-links from D. gigas beak. All cross-links presented in this report share common building blocks, a family of di-, tri-, and tetra-histidine-catecholic adducts, that were separated by affinity chromatography and high performance liquid chromatography (HPLC) and identified by tandem mass spectroscopy and proton nuclear magnetic resonance (1H NMR). The data provide additional insights into the unusually high cross-link density found in mature beaks. Furthermore, we propose both a low molecular weight catechol, and peptidyl-dopa, to be sclerotization agents of squid beak. This appears to represent a new strategy for forming hard tissue in animals. The interplay between covalent cross-linking and dehydration on the graded properties of the beaks is discussed. PMID:20870720

  1. Local Type Checking for Linked Data Consumers

    Directory of Open Access Journals (Sweden)

    Gabriel Ciobanu

    2013-07-01

    Full Text Available The Web of Linked Data is the cumulation of over a decade of work by the Web standards community in their effort to make data more Web-like. We provide an introduction to the Web of Linked Data from the perspective of a Web developer that would like to build an application using Linked Data. We identify a weakness in the development stack as being a lack of domain specific scripting languages for designing background processes that consume Linked Data. To address this weakness, we design a scripting language with a simple but appropriate type system. In our proposed architecture some data is consumed from sources outside of the control of the system and some data is held locally. Stronger type assumptions can be made about the local data than external data, hence our type system mixes static and dynamic typing. Throughout, we relate our work to the W3C recommendations that drive Linked Data, so our syntax is accessible to Web developers.

  2. Novel Link Adaptation Schemes for OFDM System

    Institute of Scientific and Technical Information of China (English)

    LEI Ming; CAI Peng; XU Yue-shan; ZHANG Ping

    2003-01-01

    Orthogonal Frequency Division Multiplexing (OFDM) is the most promising technique supporting the high data rate transmission. The combination of the link adaptation and OFDM can further increase the spectral efficiency. In this paper, we put forward two link adaptation schemes for OFDM system which have the advantages of both flexibility and practicability. Both of the two novel link adaptation schemes are based on the iterative mechanism to allocate the bit and power to subcarriers according to their channel gains and noisy levels which are assumed to be already known at the transmitter. The candidate modulation modes are determined freely before the link adaptation schemes are performed. The distinction between the two novel link adaptation schemes is that in the novel scheme A, the modulation mode is upgraded to the neighboring higher-order mode, while in the novel scheme B the modulation is upgraded to the genuine optimal mode. Therefore, the novel scheme A has the advantage of lower complexity and the novel scheme B has the advantage of higher spectral efficiency.

  3. A generalized theory of preferential linking

    Science.gov (United States)

    Hu, Haibo; Guo, Jinli; Liu, Xuan; Wang, Xiaofan

    2014-12-01

    There are diverse mechanisms driving the evolution of social networks. A key open question dealing with understanding their evolution is: How do various preferential linking mechanisms produce networks with different features? In this paper we first empirically study preferential linking phenomena in an evolving online social network, find and validate the linear preference. We propose an analyzable model which captures the real growth process of the network and reveals the underlying mechanism dominating its evolution. Furthermore based on preferential linking we propose a generalized model reproducing the evolution of online social networks, and present unified analytical results describing network characteristics for 27 preference scenarios. We study the mathematical structure of degree distributions and find that within the framework of preferential linking analytical degree distributions can only be the combinations of finite kinds of functions which are related to rational, logarithmic and inverse tangent functions, and extremely complex network structure will emerge even for very simple sublinear preferential linking. This work not only provides a verifiable origin for the emergence of various network characteristics in social networks, but bridges the micro individuals' behaviors and the global organization of social networks.

  4. Percolation of networks with directed dependency links

    CERN Document Server

    Niu, Dunbiao; Du, Minhui; Stanley, H Eugene; Hu, Yanqing

    2016-01-01

    The self-consistent probabilistic approach has proven itself powerful in studying the percolation behavior of interdependent or multiplex networks without tracking the percolation process through each cascading step. In order to understand how directed dependency links impact criticality, we employ this approach to study the percolation properties of networks with both undirected connectivity links and directed dependency links. We find that when a random network with a given degree distribution undergoes a second-order phase transition, the critical point and the unstable regime surrounding the second-order phase transition regime are determined by the proportion of nodes that do not depend on any other nodes. Moreover, we also find that the triple point and the boundary between first- and second-order transitions are determined by the proportion of nodes that depend on no more than one node. This implies that it is maybe general for multiplex network systems, some important properties of phase transitions c...

  5. [Suicidality and musical preferences: a possible link?].

    Science.gov (United States)

    Mikolajczak, Gladys; Desseilles, Martin

    2012-01-01

    Music is an important part of young people's lives. In this article, we attempt to answer two questions on the links between music et suicide. First, we examine if certain types of music favor suicidal process (ideation and acting out); and, secondly, we examine if music can constitute a tool to reduce the risk of suicide. Several factors possibly involved in links between musical preferences and the suicidal process are developed: the Velten effect and the musical mood induction procedure, the identification and the learning by imitation, the media influence as well as the individual characteristics. A multifactor approach is necessary to understand the complex and birectional links that unite musical preferences and suicide risk. PMID:23666285

  6. Mining Electronic Health Records using Linked Data.

    Science.gov (United States)

    Odgers, David J; Dumontier, Michel

    2015-01-01

    Meaningful Use guidelines have pushed the United States Healthcare System to adopt electronic health record systems (EHRs) at an unprecedented rate. Hospitals and medical centers are providing access to clinical data via clinical data warehouses such as i2b2, or Stanford's STRIDE database. In order to realize the potential of using these data for translational research, clinical data warehouses must be interoperable with standardized health terminologies, biomedical ontologies, and growing networks of Linked Open Data such as Bio2RDF. Applying the principles of Linked Data, we transformed a de-identified version of the STRIDE into a semantic clinical data warehouse containing visits, labs, diagnoses, prescriptions, and annotated clinical notes. We demonstrate the utility of this system though basic cohort selection, phenotypic profiling, and identification of disease genes. This work is significant in that it demonstrates the feasibility of using semantic web technologies to directly exploit existing biomedical ontologies and Linked Open Data.

  7. Improving personalized link prediction by hybrid diffusion

    CERN Document Server

    Liu, Jin-Hu; Zhou, Tao

    2016-01-01

    Inspired by traditional link prediction and to solve the problem of recommending friends in social networks, we introduce the personalized link prediction in this paper, in which each individual will get equal number of diversiform predictions. While the performances of many classical algorithms are not satisfactory under this framework, thus new algorithms are in urgent need. Motivated by previous researches in other fields, we generalize heat conduction process to the framework of personalized link prediction and find that this method outperforms many classical similarity-based algorithms, especially in the performance of diversity. In addition, we demonstrate that adding one ground node who is supposed to connect all the nodes in the system will greatly benefit the performance of heat conduction. Finally, better hybrid algorithms composed of local random walk and heat conduction have been proposed. Numerical results show that the hybrid algorithms can outperform other algorithms simultaneously in all four ...

  8. On Wireless Link Scheduling and Flow Control

    CERN Document Server

    Gore, Ashutosh Deepak

    2008-01-01

    This thesis focuses on link scheduling in wireless mesh networks by taking into account physical layer characteristics. The assumption made throughout is that a packet is received successfully only if the Signal to Interference and Noise Ratio (SINR) at the receiver exceeds the communication threshold. The thesis also discusses the complementary problem of flow control. (1) We consider various problems on centralized link scheduling in Spatial Time Division Multiple Access (STDMA) wireless mesh networks. We motivate the use of spatial reuse as performance metric and provide an explicit characterization of spatial reuse. We propose link scheduling algorithms based on certain graph models (communication graph, SINR graph) of the network. Our algorithms achieve higher spatial reuse than that of existing algorithms, with only a slight increase in computational complexity. (2) We investigate random access algorithms in wireless networks. We assume that the receiver is capable of power-based capture and propose a s...

  9. Quantitative linking hypotheses for infant eye movements.

    Directory of Open Access Journals (Sweden)

    Daniel Yurovsky

    Full Text Available The study of cognitive development hinges, largely, on the analysis of infant looking. But analyses of eye gaze data require the adoption of linking hypotheses: assumptions about the relationship between observed eye movements and underlying cognitive processes. We develop a general framework for constructing, testing, and comparing these hypotheses, and thus for producing new insights into early cognitive development. We first introduce the general framework--applicable to any infant gaze experiment--and then demonstrate its utility by analyzing data from a set of experiments investigating the role of attentional cues in infant learning. The new analysis uncovers significantly more structure in these data, finding evidence of learning that was not found in standard analyses and showing an unexpected relationship between cue use and learning rate. Finally, we discuss general implications for the construction and testing of quantitative linking hypotheses. MATLAB code for sample linking hypotheses can be found on the first author's website.

  10. Editorial: Link Spam and Search Engines

    Directory of Open Access Journals (Sweden)

    Alireza Noruzi

    2006-03-01

    Full Text Available The growing number of blogs has caused problems for search engines, problems such as the highly frequent blog spam. Spammers use blogs to promote their websites. Spammers are trying to win the attention of search engines, not of bloggers or their readers. Link spam dishonestly and deliberately manipulates link-based ranking algorithms of search engines like Google's PageRank to increase the rank of a web site or page so that it is placed as close to the top of search results as possible. A link-based ranking algorithm gives a higher ranking to a site that has many backlinks, especially from highly-ranked sites/pages.

  11. Discovering and Mining Links for Protein Databases

    Directory of Open Access Journals (Sweden)

    A.Immaculate Mercy

    2014-01-01

    Full Text Available This work introduces a link analysis procedure for discovering relationships in a protein database or a relational database generalizing simple correspondence analysis. It is based on extracting the links to the rela ted protein database and malfunctioned protein database. The datasets are trained in order to find out missing interactions and the sequences related to them. Further the analysis of links proceeds by performing a random walk defining a Markov chain. The e lements of interest are analysed through stochastic complementation which gives a reduced Markov chain. This reduced map is then analysed by projecting the elements of interest through Principal component analysis. Several Protein datasets are analysed using the proposed methodology, showing the usefulness of the technique for extracting relationships in relational databases or graphs.

  12. Discovering and Mining Links for Protein Databases

    Directory of Open Access Journals (Sweden)

    A. Immaculate Mercy

    2015-10-01

    Full Text Available link analysis procedure for discovering relationships in a protein database or a relational database generalizing simple correspondence analysis. It is based on extracting the links to the related protein database and malfunctioned protein database. The datasets are trained in order to find out missing interactions and the sequences related to them. Further the analysis of links proceeds by performing a random walk defining a Markov chain. The elements of interest are analysed through stochastic complementation which gives a reduced Markov chain. This reduced map is then analysed by projecting the elements of interest through Principal component analysis. Several Protein datasets are analysed using the proposed methodology, showing the usefulness of the technique for extracting relationships in relational databases or graphs.

  13. Why should we publish Linked Data?

    Science.gov (United States)

    Blower, Jon; Riechert, Maik; Koubarakis, Manolis; Pace, Nino

    2016-04-01

    We use the Web every day to access information from all kinds of different sources. But the complexity and diversity of scientific data mean that discovering accessing and interpreting data remains a large challenge to researchers, decision-makers and other users. Different sources of useful information on data, algorithms, instruments and publications are scattered around the Web. How can we link all these things together to help users to better understand and exploit earth science data? How can we combine scientific data with other relevant data sources, when standards for describing and sharing data vary so widely between communities? "Linked Data" is a term that describes a set of standards and "best practices" for sharing data on the Web (http://www.w3.org/standards/semanticweb/data). These principles can be summarised as follows: 1. Create unique and persistent identifiers for the important "things" in a community (e.g. datasets, publications, algorithms, instruments). 2. Allow users to "look up" these identifiers on the web to find out more information about them. 3. Make this information machine-readable in a community-neutral format (such as RDF, Resource Description Framework). 4. Within this information, embed links to other things and concepts and say how these are related. 5. Optionally, provide web service interfaces to allow the user to perform sophisticated queries over this information (using a language such as SPARQL). The promise of Linked Data is that, through these techniques, data will be more discoverable, more comprehensible and more usable by different communities, not just the community that produced the data. As a result, many data providers (particularly public-sector institutions) are now publishing data in this way. However, this area is still in its infancy in terms of real-world applications. Data users need guidance and tools to help them use Linked Data. Data providers need reassurance that the investments they are making in

  14. Influence of Reciprocal links in Social Networks

    CERN Document Server

    Zhu, Yu-Xiao; Sun, Gui-Quan; Tang, Ming; Zhou, Tao; Zhang, Zi-Ke

    2013-01-01

    In this Letter, we empirically study the influence of reciprocal links, in order to understand its role in affecting the structure and function of directed social networks. Experimental results on two representative datesets, Sina Weibo and Douban, demonstrate that the reciprocal links indeed play a more important role than non-reciprocal ones in both spreading information and maintaining the network robustness. In particular, the information spreading process can be significantly enhanced by considering the reciprocal effect. In addition, reciprocal links are largely responsible for the connectivity and efficiency of directed networks. This work may shed some light on the in-depth understanding and application of the reciprocal effect in directed online social networks.

  15. Urban rainfall estimation employing commercial microwave links

    Science.gov (United States)

    Overeem, Aart; Leijnse, Hidde; Uijlenhoet, Remko; ten Veldhuis, Marie-claire

    2015-04-01

    Urban areas often lack rainfall information. To increase the number of rainfall observations in cities, microwave links from operational cellular telecommunication networks may be employed. Although this new potential source of rainfall information has been shown to be promising, its quality needs to be demonstrated more extensively. In the Rain Sense kickstart project of the Amsterdam Institute for Advanced Metropolitan Solutions (AMS), sensors and citizens are preparing Amsterdam for future weather. Part of this project is rainfall estimation using new measurement techniques. Innovative sensing techniques will be utilized such as rainfall estimation from microwave links, umbrellas for weather sensing, low-cost sensors at lamp posts and in drainage pipes for water level observation. These will be combined with information provided by citizens in an active way through smartphone apps and in a passive way through social media posts (Twitter, Flickr etc.). Sensor information will be integrated, visualized and made accessible to citizens to help raise citizen awareness of urban water management challenges and promote resilience by providing information on how citizens can contribute in addressing these. Moreover, citizens and businesses can benefit from reliable weather information in planning their social and commercial activities. In the end city-wide high-resolution rainfall maps will be derived, blending rainfall information from microwave links and weather radars. This information will be used for urban water management. This presentation focuses on rainfall estimation from commercial microwave links. Received signal levels from tens of microwave links within the Amsterdam region (roughly 1 million inhabitants) in the Netherlands are utilized to estimate rainfall with high spatial and temporal resolution. Rainfall maps will be presented and compared to a gauge-adjusted radar rainfall data set. Rainfall time series from gauge(s), radars and links will be compared.

  16. Genetics Home Reference: X-linked sideroblastic anemia

    Science.gov (United States)

    ... Conditions X-linked sideroblastic anemia X-linked sideroblastic anemia Enable Javascript to view the expand/collapse boxes. ... Open All Close All Description X-linked sideroblastic anemia is an inherited disorder that prevents developing red ...

  17. Genetics Home Reference: X-linked severe combined immunodeficiency

    Science.gov (United States)

    ... Health Conditions X-linked SCID X-linked severe combined immunodeficiency Enable Javascript to view the expand/collapse ... Open All Close All Description X-linked severe combined immunodeficiency (SCID) is an inherited disorder of the ...

  18. SPARQL Query Result Explanation for Linked Data

    OpenAIRE

    Hasan, Rakebul; Endris, Kemele M.; Gandon, Fabien

    2014-01-01

    In this paper, we present an approach to explain SPARQL query results for Linked Data using why-provenance. We present a non-annotation-based algorithm to generate why-provenance and show its feasibility for Linked Data. We present an explanation-aware federated query processor prototype and show the presentation of our explanations. We present a user study to evaluate the impacts of our explanations. Our study shows that our query result explanations are helpful for end users to understand t...

  19. Link prediction based on path entropy

    CERN Document Server

    Xu, Zhongqi; Yang, Jian

    2015-01-01

    Information theory has been taken as a prospective tool for quantifying the complexity of complex networks. In this paper, we first study the information entropy or uncertainty of a path using the information theory. Then we apply the path entropy to the link prediction problem in real-world networks. Specifically, we propose a new similarity index, namely Path Entropy (PE) index, which considers the information entropies of shortest paths between node pairs with penalization to long paths. Empirical experiments demonstrate that PE index outperforms the mainstream link predictors.

  20. Microwave line of sight link engineering

    CERN Document Server

    Angueira, Pablo

    2012-01-01

    A comprehensive guide to the design, implementation, and operation of line of sight microwave link systems The microwave Line of Sight (LOS) transport network of any cellular operator requires at least as much planning effort as the cellular infrastructure itself. The knowledge behind this design has been kept private by most companies and has not been easy to find. Microwave Line of Sight Link Engineering solves this dilemma. It provides the latest revisions to ITU reports and recommendations, which are not only key to successful design but have changed dramatically in

  1. Approximate Semantic Matching Over Linked Data Streams

    OpenAIRE

    Qin, Yongrui; Yao, Lina; Sheng, Quan Z.

    2016-01-01

    In the Internet of Things (IoT),data can be generated by all kinds of smart things. In such context, enabling machines to process and understand such data is critical. Semantic Web technologies, such as Linked Data, provide an effective and machine-understandable way to represent IoT data for further processing. It is a challenging issue to match Linked Data streams semantically based on text similarity as text similarity computation is time consuming. In this paper, we present a hashing-base...

  2. A link between inflammation and metastasis

    DEFF Research Database (Denmark)

    Hansen, M. T.; Forst, B.; Cremers, N.;

    2015-01-01

    S100A4 is implicated in metastasis and chronic inflammation, but its function remains uncertain. Here we establish an S100A4-dependent link between inflammation and metastatic tumor progression. We found that the acute-phase response proteins serum amyloid A (SAA) 1 and SAA3 are transcriptional....... Furthermore, coordinate expression of S100A4 and SAA in tumor samples from colorectal carcinoma patients significantly correlated with reduced overall survival. These data show that SAA proteins are effectors for the metastasis-promoting functions of S100A4, and serve as a link between inflammation and tumor...

  3. Macromolecular Flexibility and Aggregation Tendency of Non-Cross-Linked and Cross-Linked Cationic Polysoaps

    NARCIS (Netherlands)

    Wang, Guang-Jia; Engberts, Jan B.F.N.

    1998-01-01

    The aggregation tendency of non-cross-linked and cross-linked poly(alkylmethyl-diallylammonium halides) bearing n-dodecyl and n-decyl side chains ((CL)-CopolC1-12-Cl, (CL)-CopolC1-12-Br and (CL)-CopolC1-10-Br, respectively) in aqueous solution has been evaluated by measuring their critical aggregate

  4. Inheritance of most X-linked traits is not dominant or recessive, just X-linked

    NARCIS (Netherlands)

    Dobyns, WB; Filauro, A; Tomson, BN; Chan, AS; Ho, AW; Ting, NT; Oosterwijk, JC; Ober, C

    2004-01-01

    The existence of X-linked disorders in humans has been recognized for many centuries, based on lessons in religious texts and observations of specific human families (e.g., color blindness or Daltonism). Our modern concepts of Mendelian (including X-linked) inheritance originated just after the turn

  5. FormLink/FeynCalcFormLink : Embedding FORM in Mathematica and FeynCalc

    CERN Document Server

    Feng, Feng

    2012-01-01

    FORM, a symbolic manipulation system, has been widely used in a lot of calculations for High Energy Physics due to its high performance and fficient design. Mathematica, another computational software program, has also widely been used, but more for reasons of generality and user-friendliness than for speed. Especially calculations involving tensors and noncommutative operations like calculating Dirac traces can be rather slow in Mathematica, compared to FORM. In this article we describe FormLink and FeynCalcFormLink, two Mathematica packages to link Mathematica and FeynCalc with FORM. FormLink can be used without FeynCalc and FeynCalcFormLink, which is an extension loading FormLink and FeynCalc automatically. With these two packages the impressive speed and other special features of FORM get embedded into the generality of Mathematica and FeynCalc in a simple manner. FeynCalcFormLink provides a FORM-based turbo for FeynCalc, making it much more efficient. FormLink turns Mathematica into an editor and code or...

  6. Link Margin Optimization of Free Space Optical Link under the Impact of Varying Meteorological Conditions

    Directory of Open Access Journals (Sweden)

    Amandeep Kaur Virk

    2012-03-01

    Full Text Available FSO is a free space optical technology synonymous to optical wireless communication and often called as openair photonics or infrared broadband. In free space optical communication, data is transmitted from point-to-point and multipoint using low-powered infrared lasers. FSO allows transmitting and receiving of voice, video, and data information. High speed and license free installation are the key features of this technology. The performance of FSO link is significantly affected by meteorological conditions viz. rain, scintillation, geometric attenuation and snow etc. In this paper we have formulated the link margin equation for the performanceevaluation of FSO link under varying meteorological conditions. Performance of the considered FSO link has been optimized on the basis of signal wavelength, link length and launched power level.

  7. Linked data for libraries, archives and museums how to clean, link and publish your metadata

    CERN Document Server

    Hooland, Seth van

    2014-01-01

    This highly practical handbook teaches you how to unlock the value of your existing metadata through cleaning, reconciliation, enrichment and linking and how to streamline the process of new metadata creation. Libraries, archives and museums are facing up to the challenge of providing access to fast growing collections whilst managing cuts to budgets. Key to this is the creation, linking and publishing of good quality metadata as Linked Data that will allow their collections to be discovered, accessed and disseminated in a sustainable manner. This highly practical handbook teaches you how to unlock the value of your existing metadata through cleaning, reconciliation, enrichment and linking and how to streamline the process of new metadata creation. Metadata experts Seth van Hooland and Ruben Verborgh introduce the key concepts of metadata standards and Linked Data and how they can be practically applied to existing metadata, giving readers the tools and understanding to achieve maximum results with limited re...

  8. Analysis Links Zoning Policies and Disparities

    Science.gov (United States)

    Shah, Nirvi

    2012-01-01

    Location, location, location. This mantra of real estate agents and their clients alike is now the target of a new report from the Brookings Institution linking housing prices and zoning practices to effectively depriving low-income students of high-quality schools. Using test scores from schools in the 100 largest metropolitan areas in the…

  9. Linking Individual Creativity to Organizational Innovation

    Science.gov (United States)

    Litchfield, Robert C.; Ford, Cameron M.; Gentry, Richard J.

    2015-01-01

    We draw on 146 employee-co-worker-supervisor triads from 146 organizations to examine the role of individual perspective-taking and team creative environment in the association between individual creativity and organizational innovation. Adopting an interactionist perspective, we find that the link between individual creativity and organizational…

  10. Polybinary modulation for bandwidth limited optical links

    DEFF Research Database (Denmark)

    Vegas Olmos, Juan José; Jurado-Navas, Antonio

    2015-01-01

    Optical links using traditional modulation formats are reaching a plateau in terms of capacity, mainly due to bandwidth limitations in the devices employed at the transmitter and receivers. Advanced modulation formats, which boost the spectral efficiency, provide a smooth migration path towards e...

  11. Inter-satellite links for cubesats

    NARCIS (Netherlands)

    Budianu, A.; Castro, T.J.W.; Meijerink, A.; Bentum, M.J.

    2013-01-01

    Realizing inter-satellite links is a must for ensuring the success of cubesat swarm missions. Nevertheless, it has hardly been considered until now. The communication systems for cubesats have to deal with a few peculiar demands regarding consumed power, geometry and throughput. Depending on the typ

  12. Linking brain imaging signals to visual perception.

    Science.gov (United States)

    Welchman, Andrew E; Kourtzi, Zoe

    2013-11-01

    The rapid advances in brain imaging technology over the past 20 years are affording new insights into cortical processing hierarchies in the human brain. These new data provide a complementary front in seeking to understand the links between perceptual and physiological states. Here we review some of the challenges associated with incorporating brain imaging data into such "linking hypotheses," highlighting some of the considerations needed in brain imaging data acquisition and analysis. We discuss work that has sought to link human brain imaging signals to existing electrophysiological data and opened up new opportunities in studying the neural basis of complex perceptual judgments. We consider a range of approaches when using human functional magnetic resonance imaging to identify brain circuits whose activity changes in a similar manner to perceptual judgments and illustrate these approaches by discussing work that has studied the neural basis of 3D perception and perceptual learning. Finally, we describe approaches that have sought to understand the information content of brain imaging data using machine learning and work that has integrated multimodal data to overcome the limitations associated with individual brain imaging approaches. Together these approaches provide an important route in seeking to understand the links between physiological and psychological states.

  13. Visualizing Transmedia Networks: Links, Paths and Peripheries

    Science.gov (United States)

    Ruppel, Marc Nathaniel

    2012-01-01

    'Visualizing Transmedia Networks: Links, Paths and Peripheries' examines the increasingly complex rhetorical intersections between narrative and media ("old" and "new") in the creation of transmedia fictions, loosely defined as multisensory and multimodal stories told extensively across a diverse media set. In order…

  14. A gigabit ethernet link source card.

    Energy Technology Data Exchange (ETDEWEB)

    Blair, R. E.; Dawson, J. W.; Drake, G.; Haberichter, W. N.; Schlereth, J. L.

    2002-09-18

    A Link Source Card (LSC) has been developed which employs Gigabit Ethernet as the physical medium. The LSC is implemented as a mezzanine card compliant with the S-Link specifications, and is intended for use in development of the Region of Interest Building (ROIB) in the Level 2 Trigger of ATLAS. The LSC will be used to bring Region of Internet Fragments from Level 1 Trigger elements to the ROIB, and to transfer compiled Region of Interest Records to Supervisor Processors. The card uses the LSI 8101/8104 Media Access Controller (MAC) [1] and the Agilent HDMP-1636 Transceiver. An Altera 10K50A FPGA [2] is configured to provide several state machines which perform all the tasks on the card, such as formulating the Ethernet header, read/write registers in the MAC, etc. An on-card static RAM provides storage for 512K S-Link words, and a FIFO provides 4K buffering of input S-Link words. The LSC has been tested in a setup where it transfers data to a NIC in the PCI bus of a PC.

  15. Cross-linked structure of network evolution

    Energy Technology Data Exchange (ETDEWEB)

    Bassett, Danielle S., E-mail: dsb@seas.upenn.edu [Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Department of Physics, University of California, Santa Barbara, California 93106 (United States); Sage Center for the Study of the Mind, University of California, Santa Barbara, California 93106 (United States); Wymbs, Nicholas F.; Grafton, Scott T. [Department of Psychology and UCSB Brain Imaging Center, University of California, Santa Barbara, California 93106 (United States); Porter, Mason A. [Oxford Centre for Industrial and Applied Mathematics, Mathematical Institute, University of Oxford, Oxford OX2 6GG (United Kingdom); CABDyN Complexity Centre, University of Oxford, Oxford, OX1 1HP (United Kingdom); Mucha, Peter J. [Carolina Center for Interdisciplinary Applied Mathematics, Department of Mathematics, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Department of Applied Physical Sciences, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)

    2014-03-15

    We study the temporal co-variation of network co-evolution via the cross-link structure of networks, for which we take advantage of the formalism of hypergraphs to map cross-link structures back to network nodes. We investigate two sets of temporal network data in detail. In a network of coupled nonlinear oscillators, hyperedges that consist of network edges with temporally co-varying weights uncover the driving co-evolution patterns of edge weight dynamics both within and between oscillator communities. In the human brain, networks that represent temporal changes in brain activity during learning exhibit early co-evolution that then settles down with practice. Subsequent decreases in hyperedge size are consistent with emergence of an autonomous subgraph whose dynamics no longer depends on other parts of the network. Our results on real and synthetic networks give a poignant demonstration of the ability of cross-link structure to uncover unexpected co-evolution attributes in both real and synthetic dynamical systems. This, in turn, illustrates the utility of analyzing cross-links for investigating the structure of temporal networks.

  16. Extracting Macroscopic Information from Web Links.

    Science.gov (United States)

    Thelwall, Mike

    2001-01-01

    Discussion of Web-based link analysis focuses on an evaluation of Ingversen's proposed external Web Impact Factor for the original use of the Web, namely the interlinking of academic research. Studies relationships between academic hyperlinks and research activities for British universities and discusses the use of search engines for Web link…

  17. Facilitating Collaboration Through Linked Open Data

    Science.gov (United States)

    Narock, T. W.; Rozell, E. A.; Robinson, E. M.

    2012-12-01

    The increasing volumes, complexity, and heterogeneity of scientific data are requiring members of formally disparate disciplines to come together to address today's scientific challenges. Data science is formed at the intersection of domain scientists, information specialists, librarians, computer scientists and data managers. With such a distributed and diverse community, it can be difficult to identify collaborators, keep track of current research, and assess the underlying social network. We introduce the notion of data science within the Earth and space sciences and present a novel tool for understanding the evolving research network. Linked Data, a modern paradigm for data publishing, leverages the inherent linking capabilities of the Web. Additionally, Linked Data is a machine understandable data format that enables computational reasoning and inferencing. Using this concept, we have linked data from a number of disparate sources such as, hundreds of thousands of AGU abstracts, National Science Foundation project information, people, and organizations. We highlight new collaborations and insights enabled by visualizing the relationships between publications, science data, people, organizations, and events and discuss how such an approach can benefit with extensions from the community at large.

  18. Sharp Connection: Linking Competitive Intelligence and Intranets

    NARCIS (Netherlands)

    Hendriks, P.H.J.; Jacobs, W.H.

    2003-01-01

    Assessing the value of ICT to support Competitive Intelligence presumes an understanding of the relationship between the two. The chapter argues that starting from either the ICT or CI side to this relationship and linking to the other, as most studies do, cannot secure a fully adequate conception o

  19. Cross-linked structure of network evolution

    International Nuclear Information System (INIS)

    We study the temporal co-variation of network co-evolution via the cross-link structure of networks, for which we take advantage of the formalism of hypergraphs to map cross-link structures back to network nodes. We investigate two sets of temporal network data in detail. In a network of coupled nonlinear oscillators, hyperedges that consist of network edges with temporally co-varying weights uncover the driving co-evolution patterns of edge weight dynamics both within and between oscillator communities. In the human brain, networks that represent temporal changes in brain activity during learning exhibit early co-evolution that then settles down with practice. Subsequent decreases in hyperedge size are consistent with emergence of an autonomous subgraph whose dynamics no longer depends on other parts of the network. Our results on real and synthetic networks give a poignant demonstration of the ability of cross-link structure to uncover unexpected co-evolution attributes in both real and synthetic dynamical systems. This, in turn, illustrates the utility of analyzing cross-links for investigating the structure of temporal networks

  20. Using and detecting links in Wikipedia

    NARCIS (Netherlands)

    K.N. Fachry; J. Kamps; M. Koolen; J. Zhang

    2007-01-01

    In this paper, we document our efforts at INEX 2007 where we participated in the Ad Hoc Track, the Link the Wiki Track, and the Interactive Track that continued from INEX 2006. Our main aims at INEX 2007 were the following. For the Ad Hoc Track, we investigated the effectiveness of incorporating lin

  1. The Contingencies of the Hypertext Link.

    Science.gov (United States)

    Harpold, Terence

    1991-01-01

    Argues that the accidents of reading a hypertext (changing your destination, forgetting your point of departure, or getting lost along the way) are not the effects of inappropriate cues, misinterpreted reference or poor design, but the general condition of the hypertext as text, amplified by the narrative turns of the link. (SR)

  2. Using Linked Data in Learning Analytics

    NARCIS (Netherlands)

    d'Aquin, Mathieu; Dietze, Stefan; Herder, Eelco; Drachsler, Hendrik; Taibi, David

    2014-01-01

    Learning Analytics has a lot to do with data, and the way to make sense of raw data in terms of the learner’s experience, behaviour and knowledge. In this article, we argue about the need for a closer relationship between the field of Learning Analytics and the one of Linked Data, which in our view

  3. The Missing Link: Research on Teacher Education

    Science.gov (United States)

    Wiens, Peter D.

    2012-01-01

    Teacher education has recently come under attack for its perceived lack of efficacy in preparing teachers for classroom duty. A lack of comprehensive research in teacher education makes it difficult to understand the effects of teacher education programs on student learning. There is a missing link between what happens in teacher education…

  4. A gigabit ethernet link source card

    International Nuclear Information System (INIS)

    A Link Source Card (LSC) has been developed which employs Gigabit Ethernet as the physical medium. The LSC is implemented as a mezzanine card compliant with the S-Link specifications, and is intended for use in development of the Region of Interest Building (ROIB) in the Level 2 Trigger of ATLAS. The LSC will be used to bring Region of Internet Fragments from Level 1 Trigger elements to the ROIB, and to transfer compiled Region of Interest Records to Supervisor Processors. The card uses the LSI 8101/8104 Media Access Controller (MAC) [1] and the Agilent HDMP-1636 Transceiver. An Altera 10K50A FPGA [2] is configured to provide several state machines which perform all the tasks on the card, such as formulating the Ethernet header, read/write registers in the MAC, etc. An on-card static RAM provides storage for 512K S-Link words, and a FIFO provides 4K buffering of input S-Link words. The LSC has been tested in a setup where it transfers data to a NIC in the PCI bus of a PC

  5. Met1-linked Ubiquitination in Immune Signalling

    DEFF Research Database (Denmark)

    Fiil, Berthe Katrine; Gyrd-Hansen, Mads

    2014-01-01

    Methionine 1-linked ubiquitin chains (Met1-Ub), or linear ubiquitin, has emerged as a central post-translational modification in innate immune signalling. Molecular machinery that assembles, senses and, more recently, disassembles Met1-Ub has been identified, and technical advances have enabled...

  6. Linking Large-Scale Reading Assessments: Comment

    Science.gov (United States)

    Hanushek, Eric A.

    2016-01-01

    E. A. Hanushek points out in this commentary that applied researchers in education have only recently begun to appreciate the value of international assessments, even though there are now 50 years of experience with these. Until recently, these assessments have been stand-alone surveys that have not been linked, and analysis has largely focused on…

  7. Improving personalized link prediction by hybrid diffusion

    Science.gov (United States)

    Liu, Jin-Hu; Zhu, Yu-Xiao; Zhou, Tao

    2016-04-01

    Inspired by traditional link prediction and to solve the problem of recommending friends in social networks, we introduce the personalized link prediction in this paper, in which each individual will get equal number of diversiform predictions. While the performances of many classical algorithms are not satisfactory under this framework, thus new algorithms are in urgent need. Motivated by previous researches in other fields, we generalize heat conduction process to the framework of personalized link prediction and find that this method outperforms many classical similarity-based algorithms, especially in the performance of diversity. In addition, we demonstrate that adding one ground node that is supposed to connect all the nodes in the system will greatly benefit the performance of heat conduction. Finally, better hybrid algorithms composed of local random walk and heat conduction have been proposed. Numerical results show that the hybrid algorithms can outperform other algorithms simultaneously in all four adopted metrics: AUC, precision, recall and hamming distance. In a word, this work may shed some light on the in-depth understanding of the effect of physical processes in personalized link prediction.

  8. Experimental and preoperational optical intersatellite links

    Science.gov (United States)

    Wittig, M.; Oppenhaeuser, G.; Hahne, A.

    1988-01-01

    ESA's Semiconductor Intersatellite Laser Experiment, 'SILEX', is a baseline in-orbit demonstration mission for optical communications payloads and encompasses the GEO-1 and GEO-2 geostationary satellites; a third system spacecraft may be any LEO, perhaps earth remote-sensing, satellite. Attention is presently given to problems of optical intersatellite communications links, and the design of prospective in-orbit experiments.

  9. LODE: Linking Open Descriptions of Events

    NARCIS (Netherlands)

    Shaw, R.; Troncy, R.; Hardman, L.

    2009-01-01

    People conventionally refer to an action or occurrence taking place at a certain time at a specific location as an event. This notion is potentially useful for connecting individual facts recorded in the rapidly growing collection of linked data sets and for discovering more complex relationships be

  10. Benchmarking Linked Open Data Management Systems

    NARCIS (Netherlands)

    Angles Rojas, R.; Pham, M.D.; Boncz, P.A.

    2014-01-01

    With inherent support for storing and analysing highly interconnected data, graph and RDF databases appear as natural solutions for developing Linked Open Data applications. However, current benchmarks for these database technologies do not fully attain the desirable characteristics in industrial-st

  11. Linking earthquakes and hydraulic fracturing operations

    Science.gov (United States)

    Balcerak, Ernie

    2013-01-01

    Hydraulic fracturing, also known as fracking, to extract oil and gas from rock, has been a controversial but increasingly common practice; some studies have linked it to groundwater contamination and induced earthquakes. Scientists discussed several studies on the connection between fracking and earthquakes at the AGU Fall Meeting in San Francisco in December.

  12. A Verified Algebra for Linked Data

    Directory of Open Access Journals (Sweden)

    Ross Horne

    2011-07-01

    Full Text Available A foundation is investigated for the application of loosely structured data on the Web. This area is often referred to as Linked Data, due to the use of URIs in data to establish links. This work focuses on emerging W3C standards which specify query languages for Linked Data. The approach is to provide an abstract syntax to capture Linked Data structures and queries, which are then internalised in a process calculus. An operational semantics for the calculus specifies how queries, data and processes interact. A labelled transition system is shown to be sound with respect to the operational semantics. Bisimulation over the labelled transition system is used to verify an algebra over queries. The derived algebra is a contribution to the application domain. For instance, the algebra may be used to rewrite a query to optimise its distribution across a cluster of servers. The framework used to provide the operational semantics is powerful enough to model related calculi for the Web.

  13. Quilts and Tangrams: Linking Literature and Geometry.

    Science.gov (United States)

    Bohning, Gerry; Williams, Rebecca

    1997-01-01

    Suggests that by making quilt squares with tangrams, children link geometry and children's literature. Provides background on quilts and tangrams, and provides guidelines for teachers. Points out that children gain communication and mathematical thinking skills as they manipulate and explore relationships among pieces. Contains an annotated…

  14. Auditing Dynamic Links to Online Information Resources

    Science.gov (United States)

    Li, Jianhua; Cimino, James J.

    2007-01-01

    The Columbia University Infobutton Manager (IM) is a system that provides dynamically generated, context-specific links between clinical information systems and online information resources. The resources range from local documents, to commercially available document sets and search engines. The links provided by the IM can be reliably created, but there is no guarantee that they will function reliably, since the resources to which they point are subject to unannounced changes and failures. We have developed a set of tools to audit the links periodically to determine if the resources are available and if the IM has sufficient information to generate all the links needed by its users. These tools have been in use since February, 2006 and have provided timely warnings on many occasions. These warnings have allowed us to correct problems with resource access before they became apparent to our users and often before the resource maintainers were aware of the problems. The tools have thus helped us provide clinicians with a dependable level of service. PMID:18693876

  15. Mechanically linked polyrotaxanes : A stepwise approach

    NARCIS (Netherlands)

    Werts, MPL; van den Boogaard, M; Tsivgoulis, GM; Hadziioannou, G

    2003-01-01

    A new synthetic approach for the preparation of mechanically linked polyrotaxanes was developed. Two variations of rotaxane monomers were synthesized, based on diphenylmethane and tetraphenylmethane blocking groups. Both rotaxanes bear a protected phenol functionality in the dumbbell-shaped part and

  16. Linking Locations: Storytelling with Pervasive Technology

    OpenAIRE

    Jewell, Michael O.; Hooper, Clare J.

    2011-01-01

    With online location-aware smart phones in more and more pockets, storytelling is moving to the streets. Simultane- ously, an increasing abundance of Linked Data is being made available, complete with geographical information. In this paper, we review the state of the art and suggest approaches to, and issues with, a storytelling system that combines these two technologies.

  17. A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis.

    Science.gov (United States)

    Stark, Romana; Guebre-Egziabher, Fitsum; Zhao, Xiaojian; Feriod, Colleen; Dong, Jianying; Alves, Tiago C; Ioja, Simona; Pongratz, Rebecca L; Bhanot, Sanjay; Roden, Michael; Cline, Gary W; Shulman, Gerald I; Kibbey, Richard G

    2014-03-14

    Synthesis of phosphoenolpyruvate (PEP) from oxaloacetate is an absolute requirement for gluconeogenesis from mitochondrial substrates. Generally, this reaction has solely been attributed to the cytosolic isoform of PEPCK (PEPCK-C), although loss of the mitochondrial isoform (PEPCK-M) has never been assessed. Despite catalyzing the same reaction, to date the only significant role reported in mammals for the mitochondrial isoform is as a glucose sensor necessary for insulin secretion. We hypothesized that this nutrient-sensing mitochondrial GTP-dependent pathway contributes importantly to gluconeogenesis. PEPCK-M was acutely silenced in gluconeogenic tissues of rats using antisense oligonucleotides both in vivo and in isolated hepatocytes. Silencing PEPCK-M lowers plasma glucose, insulin, and triglycerides, reduces white adipose, and depletes hepatic glycogen, but raises lactate. There is a switch of gluconeogenic substrate preference to glycerol that quantitatively accounts for a third of glucose production. In contrast to the severe mitochondrial deficiency characteristic of PEPCK-C knock-out livers, hepatocytes from PEPCK-M-deficient livers maintained normal oxidative function. Consistent with its predicted role, gluconeogenesis rates from hepatocytes lacking PEPCK-M are severely reduced for lactate, alanine, and glutamine, but not for pyruvate and glycerol. Thus, PEPCK-M has a direct role in fasted and fed glucose homeostasis, and this mitochondrial GTP-dependent pathway should be reconsidered for its involvement in both normal and diabetic metabolism. PMID:24497630

  18. High speed radiation tolerant data links

    Energy Technology Data Exchange (ETDEWEB)

    Brewer, Forrest [Univ. of California, Santa Barbara, CA (United States); Incandela, Joseph [Univ. of California, Santa Barbara, CA (United States)

    2016-04-01

    This project was slated to design and develop Rad-Hard IP components for 1Gb/s links and supporting hardware designs such as PLL, SER/DES, pad drivers and receivers and custom protocol hardware for the 1Gb/s channel. Also included in the proposal was a study of a hardened memory to be used as a packet buffer for channel and data concentrator components to meet the 1 Gb/s specification. Over the course of the proposal, technology change and innovation of hardware designs lead us away from the 1 Gb/s goal to contemplate much higher performance link IP which, we believed better met the goals of physics experiments. Note that CERN microelectronics had managed to create a 4.7 Gb/s link designed to drive optical fibers and containing infrastructure for connecting much lower bandwidth front-end devices. Our own work to that point had shown the possibility of constructing a link with much lower power, lower physical overhead but of equivalent performance that could be designed to integrate directly onto the front-end ASIC (ADC and data encoding) designs. Substantial overall power savings and experimental simplicity could be achieved by eliminating data transmission to data concentrators and data concentrators and related hardened buffering themselves, with conversion to optical media at a removed distance from the experiment core. We had already developed and tested Rad-Hard SER/DES components (1Gb in 130nm standard cells) and redundant Pad Drivers/Receivers (3+ Gb/s designed and measured performance), and had a viable 1Gb/s link design based on redundant a stuttered clock receiver and classical PLL, so the basic goals of the proposal had been achieved. Below, in chronological order, are the products and tools we constructed, as well as our tests and publications.

  19. DC-Link Compensation Method for Slim DC Link Drives Fed by Soft Grid

    DEFF Research Database (Denmark)

    Mathe, Laszlo; Rosendahl Andersen, Henrik; Lazar, Radu;

    2010-01-01

    harmonic distortion (PWHD) of the line current are degraded, if resonance between the line impedance and the DC-link capacitance occurs. Likewise, the motor performance is affected negatively giving extra torque ripple, vibration and acoustic-noise emission. This paper proposes a novel DC-link compensation...... method, which ensures the stability of the slim DC-link on a soft grid. The proposed compensation method may be used for open- and closedloop control schemes, requiring a small overhead in the digital implementation....

  20. Weighting links based on edge centrality for community detection

    Science.gov (United States)

    Sun, Peng Gang

    2014-01-01

    Link weights have the equally important position as links in complex networks, and they are closely associated with each other for the emergence of communities. How to assign link weights to make a clear distinction between internal links of communities and external links connecting communities is of vital importance for community detection. Edge centralities provide a powerful approach for distinguishing internal links from external ones. Here, we first use edge centralities such as betweenness, information centrality and edge clustering coefficient to weight links of networks respectively to transform unweighted networks into weighted ones, and then a weighted function that both considers links and link weights is adopted on the weighted networks for community detection. We evaluate the performance of our approach on random networks as well as real-world networks. Better results are achieved on weighted networks with stronger weights of internal links of communities, and the results on unweighted networks outperform that of weighted networks with weaker weights of internal links of communities. The availability of our findings is also well-supported by the study of Granovetter that the weak links maintain the global integrity of the network while the strong links maintain the communities. Especially in the Karate club network, all the nodes are correctly classified when we weight links by edge betweenness. The results also give us a more comprehensive understanding on the correlation between links and link weights for community detection.

  1. On the classification of links up to finite type

    DEFF Research Database (Denmark)

    Habegger, Nathan; Meilhan, Jean-Baptiste

    We use an action, of 2l-component string links on l-component string links, defined by the first author and Xiao-Song Lin, to lift the indeterminacy of finite type link invariants. The set of links up to this new indeterminacy is in bijection with the orbit space of the restriction of this action...

  2. Method of preparing cross-linked enzyme particles

    NARCIS (Netherlands)

    Mateo, C.; Van Langen, L.M.; Van Rantwijk, F.

    2004-01-01

    The invention relates to a method of preparing cross-linked enzyme particles using a cross-linking agent. According to the invention, the enzyme particles are formed and subsequently cross-linked using a cross-linking agent having at least n reactive groups where N>=3 and a molecular weight of >2,00

  3. The cross linking of EPDM and NBR rubber

    Directory of Open Access Journals (Sweden)

    Samardžija-Jovanović Suzana

    2005-01-01

    Full Text Available In the process of macromolecule cross linking, the choice of type and quantity of the components and the experimental conditions are important to obtain the new cross linked materials with better mechanical and chemical characteristics. The cross linking method depends on the rubber type and structure. Intermolecular cross linking results in the formation elastomer network. The basis of the cross linking process, between ethylene propylene diene rubber (EPDM and acrylonitrile butadiene rubber (NBR, is a chemical reaction. Fillers and other additives are present in different mass ratios in the material. The exploitation properties of the cross linked materials depend on the quantity of additive in the cross linked systems.

  4. Classification of Framed Links in 3-Manifolds

    Indian Academy of Sciences (India)

    Matija Cencelj; Dušan Repovš; Mikhail B Skopenkov

    2007-08-01

    We present a short and complete proof of the following Pontryagin theorem, whose original proof was complicated and has never been published in detail. Let be a connected oriented closed smooth 3-manifold, $L_1(M)$ be the set of framed links in up to a framed cobordism, and $\\deg: L_1(M)→ H_1(M;\\mathbb{Z})$ be the map taking a framed link to its homology class. Then for each $\\in H_1(M;\\mathbb{Z})$ there is a one-to-one correspondence between the set $\\deg^{-1}$ and the group $\\mathbb{Z}_{2d()}$, where () is the divisibility of the projection of to the free part of $H_1(M;\\mathbb{Z})$.

  5. Computational intelligence, medicine and biology selected links

    CERN Document Server

    Zaitseva, Elena

    2015-01-01

    This book contains an interesting and state-of the art collection of chapters presenting several examples of attempts to developing modern tools utilizing computational intelligence in different real life problems encountered by humans. Reasoning, prediction, modeling, optimization, decision making, etc. need modern, soft and intelligent algorithms, methods and methodologies to solve, in the efficient ways, problems appearing in human activity. The contents of the book is divided into two parts. Part I, consisting of four chapters, is devoted to selected links of computational intelligence, medicine, health care and biomechanics. Several problems are considered: estimation of healthcare system reliability, classification of ultrasound thyroid images, application of fuzzy logic to measure weight status and central fatness, and deriving kinematics directly from video records. Part II, also consisting of four chapters, is devoted to selected links of computational intelligence and biology. The common denominato...

  6. Homogeneous links and the Seifert matrix

    CERN Document Server

    Manchón, P M G

    2011-01-01

    Homogeneous links were introduced by Peter Cromwell, who proved that the projection surface of these links, that given by the Seifert algorithm, has minimal genus. Here we provide a different proof, with a geometric rather than combinatorial flavor. To do this, we first show a direct relation between the Seifert matrix and the decomposition into blocks of the Seifert graph. Precisely, we prove that the Seifert matrix can be arranged in a block triangular form, with small boxes in the diagonal corresponding to the blocks of the Seifert graph. Then we prove that the boxes in the diagonal has non-zero determinant, by looking at an explicit matrix of degrees given by the planar structure of the Seifert graph. The paper contains also a complete classification of the homogeneous knots of genus one.

  7. The missing link between values and behaviour

    DEFF Research Database (Denmark)

    Brunsø, Karen

    For a long time human values have been perceived as abstrat cognitions representing desired goals or end-states which motivate humnan behaviour. A number of studies have tried to explore the link between values and behaviour, but often different constructs are included as intermediate links between...... values and specific behaviour, since values may be too abstract to influence behaviour directly. We propose the concept of lifestyle as a mediator between values and behaviour, and present our approach to lifestyle based on principles from cognitive psychology, where we distinguish between values...... and lifestyle and behaviour. Based on this appraoch we collected data covering values, lifestyle and behaviour, and estimated the cogntiive hierarchy from values to lifestyle to behaviour by structural equation models....

  8. Teleoperation over low bandwidth communication links

    International Nuclear Information System (INIS)

    Teleoperation is well established for many areas of hazardous environment working. Where such environments are well structured and contained, such as within a working plant, communications bandwidths need not be a constraining factor. However where the worksite is remote, large, poorly structured or damaged communications rapidly become a critical factor in the efficient deployment and use of teleoperation equipment. The paper justifies and describes means which we are exploring to reduce the required communications bandwidth for teleoperation whist retaining full functionality. Techniques involved include incorporation of local intelligence at the worksite, with bandwidth devoted to high-level up-link control signals and down-link feedback, and the use of highly compressed video feeding 'virtual reality type' HMDs to provide maximum system transparency for the operator. The work is drawing on previous experience with an 'anthropomorphic robot heat' for telepresence work, and proprietary algorithms capable of compressing full colour video to standard telephone modem data rates. (Author)

  9. LinkedIn的生财模式

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Facebook总是不断折腾,而LinkedIn却一直在闷头发财,最好的理解二者区别的方法就是考察这两家网站的财务效率。根据ComScore的数据以及公开披露的财务资料,我们可以大概估算每个用户浏览一小时后,两家网站各自能获取的收入。LinkedIn为1.3美元,而Facebook只有可怜的6.2美分。

  10. Discovering Resume Information using linked data

    Directory of Open Access Journals (Sweden)

    Ujjal Marjit

    2012-05-01

    Full Text Available In spite of having different web applications to create and collect resumes, these web applications suffer mainly from a common standard data model, data sharing, and data reusing. Though, different web applications provide same quality of resume information, but internally there are many differences in terms of data structure and storage which makes computer difficult to process and analyse the information from different sources. The concept of Linked Data has enabled the web to share data among different data sources and to discover any kind of information while resolving the issues like heterogeneity, interoperability, and data reusing between different data sources and allowing machine process-able data on the web. In this paper we present Linked Data approach to discover resume information enabling the task aggregation, sharing and reusing the information among different resume information providers and organizations. We also demonstrate experimental results on semantically rich resume information.

  11. Link Graph Analysis for Adult Images Classification

    CERN Document Server

    Kharitonov, Evgeny; Muchnik, Ilya; Romanenko, Fedor; Belyaev, Dmitry; Kotlyarov, Dmitry

    2010-01-01

    In order to protect an image search engine's users from undesirable results adult images' classifier should be built. The information about links from websites to images is employed to create such a classifier. These links are represented as a bipartite website-image graph. Each vertex is equipped with scores of adultness and decentness. The scores for image vertexes are initialized with zero, those for website vertexes are initialized according to a text-based website classifier. An iterative algorithm that propagates scores within a website-image graph is described. The scores obtained are used to classify images by choosing an appropriate threshold. The experiments on Internet-scale data have shown that the algorithm under consideration increases classification recall by 17% in comparison with a simple algorithm which classifies an image as adult if it is connected with at least one adult site (at the same precision level).

  12. Depression And The Link With Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Arup Kumar Dhar

    2016-03-01

    Full Text Available This review provides an outline of the association between major depressive disorder (MDD and coronary heart disease (CHD. Much is known about the two individual clinical conditions; however it is not until recently, that biological mechanisms have been uncovered that link both MDD and CHD. The activation of stress pathways have been implicated as a neurochemical mechanism that links MDD and CHD. Depression is known to be associated with poorer outcomes of CHD. Psychological factors such as major depression and stress are now known as risk factors for developing CHD which is as important and is independent of classic risk factors such as hypertension, diabetes mellitus and cigarette smoking. Both conditions have great socioeconomic importance given that depression and CHD are likely to be two of the three leading causes of global burden of disease. Better understanding of the common causal pathways will help us delineate more appropriate treatments.

  13. [Riboflavin UVA cross-linking for keratoconus].

    Science.gov (United States)

    Maier, P; Reinhard, T

    2013-09-01

    Keratoconus is a progressive, ectatic disease of the cornea leading to thinning and highly irregular astigmatism. Until recently all treatment options, such as prescription of glasses or contact lenses were symptomatic and neither keratoplasty nor the implantation of intracorneal rings can heal the disease. Riboflavin ultraviolet A (UVA) collagen cross-linking (CXL) cannot heal keratoconus either but promises to halt the progression. The therapeutic principle is a photochemical reaction of riboflavin and UVA light leading to free oxygen radicals in the corneal stroma that induce covalent linking of the collagen fibrils. This stiffening effect should stop the progression. After the first reports at the end of the 1990s the treatment was widely used and many case series show that CXL can be effective in stopping disease progression in some patients. However, randomized, controlled multicenter trials showing high evidence of the treatment effectiveness are rare. This report includes a review of the literature regarding treatment effectiveness, indications and new developments. PMID:23760423

  14. kpath: integration of metabolic pathway linked data.

    Science.gov (United States)

    Navas-Delgado, Ismael; García-Godoy, María Jesús; López-Camacho, Esteban; Rybinski, Maciej; Reyes-Palomares, Armando; Medina, Miguel Ángel; Aldana-Montes, José F

    2015-01-01

    In the last few years, the Life Sciences domain has experienced a rapid growth in the amount of available biological databases. The heterogeneity of these databases makes data integration a challenging issue. Some integration challenges are locating resources, relationships, data formats, synonyms or ambiguity. The Linked Data approach partially solves the heterogeneity problems by introducing a uniform data representation model. Linked Data refers to a set of best practices for publishing and connecting structured data on the Web. This article introduces kpath, a database that integrates information related to metabolic pathways. kpath also provides a navigational interface that enables not only the browsing, but also the deep use of the integrated data to build metabolic networks based on existing disperse knowledge. This user interface has been used to showcase relationships that can be inferred from the information available in several public databases. PMID:26055101

  15. An Accurate Link Correlation Estimator for Improving Wireless Protocol Performance

    Directory of Open Access Journals (Sweden)

    Zhiwei Zhao

    2015-02-01

    Full Text Available Wireless link correlation has shown significant impact on the performance of various sensor network protocols. Many works have been devoted to exploiting link correlation for protocol improvements. However, the effectiveness of these designs heavily relies on the accuracy of link correlation measurement. In this paper, we investigate state-of-the-art link correlation measurement and analyze the limitations of existing works. We then propose a novel lightweight and accurate link correlation estimation (LACE approach based on the reasoning of link correlation formation. LACE combines both long-term and short-term link behaviors for link correlation estimation. We implement LACE as a stand-alone interface in TinyOS and incorporate it into both routing and flooding protocols. Simulation and testbed results show that LACE: (1 achieves more accurate and lightweight link correlation measurements than the state-of-the-art work; and (2 greatly improves the performance of protocols exploiting link correlation.

  16. Multiple Pathways Linking Racism to Health Outcomes

    OpenAIRE

    Harrell, Camara Jules P.; Burford, Tanisha I.; Cage, Brandi N.; Nelson, Travette McNair; Shearon, Sheronda; Thompson, Adrian; Green, Steven

    2011-01-01

    This commentary discusses advances in the conceptual understanding of racism and selected research findings in the social neurosciences. The traditional stress and coping model holds that racism constitutes a source of aversive experiences that, when perceived by the individual, eventually lead to poor health outcomes. Current evidence points to additional psychophysiological pathways linking facets of racist environments with physiological reactions that contribute to disease. The alternativ...

  17. Alpha thalassaemia-mental retardation, X linked

    OpenAIRE

    Gibbons Richard

    2006-01-01

    Abstract X-linked alpha thalassaemia mental retardation (ATR-X) syndrome in males is associated with profound developmental delay, facial dysmorphism, genital abnormalities and alpha thalassaemia. Female carriers are usually physically and intellectually normal. So far, 168 patients have been reported. Language is usually very limited. Seizures occur in about one third of the cases. While many patients are affectionate with their caregivers, some exhibit autistic-like behaviour. Patients pres...

  18. Tracking Federated Queries in the Linked Data

    OpenAIRE

    Nassopoulos, Georges; Serrano-Alvarado, Patricia; Molli, Pascal; Desmontils, Emmanuel

    2015-01-01

    Federated query engines allow data consumers to execute queries over the federation of Linked Data (LD). However, as feder-ated queries are decomposed into potentially thousands of subqueries distributed among SPARQL endpoints, data providers do not know fed-erated queries, they only know subqueries they process. Consequently, unlike warehousing approaches, LD data providers have no access to secondary data. In this paper, we propose FETA (FEderated query TrAcking), a query tracking algorithm...

  19. Link homology and equivariant gauge theory

    OpenAIRE

    Poudel, Prayat; Saveliev, Nikolai

    2015-01-01

    The singular instanton Floer homology was defined by Kronheimer and Mrowka in connection with their proof that the Khovanov homology is an unknot detector. We study this theory for knots and two-component links using equivariant gauge theory on their double branched covers. We show that the special generator in the singular instanton Floer homology of a knot is graded by the knot signature mod 4, thereby providing a purely topological way of fixing the absolute grading in the theory. Our appr...

  20. Hypercubic smeared links for dynamical fermions

    Energy Technology Data Exchange (ETDEWEB)

    Hasenfratz, A.; Hoffmann, R. [Colorado Univ., Boulder, CO (United States). Dept. of Physics; Schaefer, S. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC

    2007-02-15

    We investigate a variant of hypercubic gauge link smearing where the SU(3) projection is replaced with a normalization to the corresponding unitary group. This smearing is differentiable and thus suitable for use in dynamical fermion simulations using molecular dynamics type algorithms. We show that this smearing is as efficient as projected hypercubic smearing in removing ultraviolet noise from the gauge fields. We test the normalized hypercubic smearing in dynamical improved (clover) Wilson and valence overlap simulations. (orig.)

  1. Optical Link of the Atlas Pixel Detector

    OpenAIRE

    Gan, K. K.

    2007-01-01

    The on-detector optical link of the ATLAS pixel detector contains radiation-hard receiver chips to decode bi-phase marked signals received on PIN arrays and data transmitter chips to drive VCSEL arrays. The components are mounted on hybrid boards (opto-boards). We present results from the irradiation studies with 24 GeV protons up to 32 Mrad (1.2 x 10^15 p/cm^2) and the experience from the production.

  2. Compressive Link Acquisition in Multiuser Communications

    OpenAIRE

    Li, Xiao; Rueetschi, Andrea; Scaglione, Anna; Eldar, Yonina C.

    2012-01-01

    An important receiver operation is to detect the presence specific preamble signals with unknown delays in the presence of scattering, Doppler effects and carrier offsets. This task, referred to as "link acquisition", is typically a sequential search over the transmitted signal space. Recently, many authors have suggested applying sparse recovery algorithms in the context of similar estimation or detection problems. These works typically focus on the benefits of sparse recovery, but not gener...

  3. Personalized Federated Search at LinkedIn

    OpenAIRE

    Arya, Dhruv; Ha-Thuc, Viet; Sinha, Shakti

    2016-01-01

    LinkedIn has grown to become a platform hosting diverse sources of information ranging from member profiles, jobs, professional groups, slideshows etc. Given the existence of multiple sources, when a member issues a query like "software engineer", the member could look for software engineer profiles, jobs or professional groups. To tackle this problem, we exploit a data-driven approach that extracts searcher intents from their profile data and recent activities at a large scale. The intents s...

  4. Long haul underwater fiber optic link

    OpenAIRE

    Frank A. Denap

    1988-01-01

    Approved for public release; distribution is unlimited This thesis presents the design test and evaluation of a fiber optic remote monitoring system. Practical aspects of loss measurement, link analysis, receiver design, and controller implementation are examined. The fundamental operation of the system relies on conversion of the voltage data to be a variable frequency TTL pulse train. The pulse train modulates a 1300 nm laser, which transmits the telemetry data via single mode fiber to t...

  5. Linking Notch signaling to ischemic stroke

    OpenAIRE

    Arboleda-Velasquez, Joseph F.; Zhou, Zhipeng; Shin, Hwa Kyoung; Louvi, Angeliki; Kim, Hyung-Hwan; Savitz, Sean I.; Liao, James K.; Salomone, Salvatore; Ayata, Cenk; Moskowitz, Michael A.; Artavanis-Tsakonas, Spyros

    2008-01-01

    Vascular smooth muscle cells (SMCs) have been implicated in the pathophysiology of stroke, the third most common cause of death and the leading cause of long-term neurological disability in the world. However, there is little insight into the underlying cellular pathways that link SMC function to brain ischemia susceptibility. Using a hitherto uncharacterized knockout mouse model of Notch 3, a Notch signaling receptor paralogue highly expressed in vascular SMCs, we uncover a striking suscepti...

  6. Evaluation Of Radio Links And Networks

    OpenAIRE

    Jean-Paul M. G. Linnartz; Diesta, Rolando F.

    1996-01-01

    This study evaluates the performance of radio links and networks to support communication with Automatic Vehicle Control Systems (AVCS). It addresses both vehicle-to-vehicle communication and roadside-to-vehicle communication. The report contributes to the modelling of short range vehicle-to-vehicle channels, not only in terms of documenting measured results and channel parameters, but also in extending existing models to cover antenna mobility at both receiver and transmitter simultaneously....

  7. Sexuality and occupational therapy: Exploring the link

    OpenAIRE

    Simó i Algado, Salvador; Sakellariou, Dikaios

    2006-01-01

    Holism is perceived to be one of the major tenets of occupational therapy. This article discusses the relevance of sexuality to holistic health care and contributes to the continuing discussion regarding the legitimacy of sexuality as an area of concern for occupational therapists. Sexuality is an important part of the human experience and is linked closely with spirituality. However, it is often neglected by occupational therapists. The article explores the occupational nat...

  8. Link between vitamin D and airway remodeling

    OpenAIRE

    Berraies A; Hamzaoui K; Hamzaoui A

    2014-01-01

    Anissa Berraies, Kamel Hamzaoui, Agnes HamzaouiPediatric Respiratory Diseases Department, Abderrahmen Mami Hospital, Ariana, and Research Unit 12SP15 Tunis El Manar University, Tunis, TunisiaAbstract: In the last decade, many epidemiologic studies have investigated the link between vitamin D deficiency and asthma. Most studies have shown that vitamin D deficiency increases the risk of asthma and allergies. Low levels of vitamin D have been associated with asthma severity and loss of control, ...

  9. Linking Virus Genomes with Host Taxonomy.

    Science.gov (United States)

    Mihara, Tomoko; Nishimura, Yosuke; Shimizu, Yugo; Nishiyama, Hiroki; Yoshikawa, Genki; Uehara, Hideya; Hingamp, Pascal; Goto, Susumu; Ogata, Hiroyuki

    2016-03-01

    Environmental genomics can describe all forms of organisms--cellular and viral--present in a community. The analysis of such eco-systems biology data relies heavily on reference databases, e.g., taxonomy or gene function databases. Reference databases of symbiosis sensu lato, although essential for the analysis of organism interaction networks, are lacking. By mining existing databases and literature, we here provide a comprehensive and manually curated database of taxonomic links between viruses and their cellular hosts.

  10. Cross-linking Chemistry of Squid Beak*

    OpenAIRE

    Miserez, Ali; Rubin, Daniel; Waite, J. Herbert

    2010-01-01

    In stark contrast to most aggressive predators, Dosidicus gigas (jumbo squids) do not use minerals in their powerful mouthparts known as beaks. Their beaks instead consist of a highly sclerotized chitinous composite with incremental hydration from the tip to the base. We previously reported l-3,4-dihydroxyphenylalanine (dopa)-histidine (dopa-His) as an important covalent cross-link providing mechanical strengthening to the beak material. Here, we present a more complete characterization of th...

  11. Linking global turnover of species and environments

    OpenAIRE

    Buckley, Lauren B.; Jetz, Walter

    2008-01-01

    Patterns of species turnover are central to the geography of biodiversity and resulting challenges for conservation, but at broad scales remain relatively little understood. Here, we take a first spatially-explicitly and global perspective to link the spatial turnover of species and environments. We compare how major groups of vertebrate ectotherms (amphibians) and endotherms (birds) respond to spatial environmental gradients. We find that high levels of species turnover occur regardless of e...

  12. Savings and prize-linked savings accounts

    OpenAIRE

    Atalay, Kadir; Bakhtiar, Fayzan; Cheung, Stephen L.; Slonim, Robert

    2012-01-01

    Many households have insufficient savings to handle moderate and routine consumption shocks. Many of these financially fragile households also have the highest lottery expenditures as a proportion of income. This combination suggests that Prize-Linked Savings (PLS) accounts, that combine principal-security with lottery-type jackpots, can increase savings among these at-risk households. Results from an online experiment show that the introduction of PLS accounts increase total savings and redu...

  13. Detection Implicit Links and G-betweenness

    OpenAIRE

    Zhenirovskyy, M. I.; Lande, D. V.; Snarskii, A. A.

    2010-01-01

    A concept of implicit links for Complex Networks has been defined and a new value - cohesion factor, which allows to evaluate numerically the presence of such connection between any two nodes, has been introduced. We introduce a generalization of such characteristics as the betweenness, which allows to rank network nodes in more details. The effectiveness of the proposed concepts is shown by the numerical examples.

  14. Towards Performing Arts Information As Linked Data?

    OpenAIRE

    Le Boeuf, Patrick

    2012-01-01

    International audience Semantic Web technologies and Linked Data are of crucial importance for cultural heritage institutions, as they will allow them to share data, both among them and with any kind of other agents who will be thus enabled to reuse that valuable knowledge in a variety of ways. They rely, among other things, on ontologies that provide unified representations of the (often heterogeneous) information produced by such institutions. The FRBROO model (Functional Requirements fo...

  15. Link between chips and cutting moments evolution

    CERN Document Server

    Cahuc, Olivier; Gérard, Alain; 10.4028/WWW.scientific.net/AMR.423.89

    2012-01-01

    The better understanding of the material cutting process has been shown with the benefit of the forces and moments measurement since some years ago. In paper, simultaneous six mechanical components and chip orientation measurements were realized during turning tests. During these tests, the influence of the depth of cut or feed rate has been observed and a link between the chip orientation and the moment vector orientation or the central axis characteristics has been shown.

  16. Linking numbers, spin, and statistics of solitons

    Science.gov (United States)

    Wilczek, F.; Zee, A.

    1983-01-01

    The spin and statistics of solitons in the (2 + 1)- and (3 + 1)-dimensional nonlinear sigma models is considered. For the (2 + 1)-dimensional case, there is the possibility of fractional spin and exotic statistics; for 3 + 1 dimensions, the usual spin-statistics relation is demonstrated. The linking-number interpretation of the Hopf invariant and the use of suspension considerably simplify the analysis.

  17. Linking corporate strategy and supply chain management

    OpenAIRE

    Hofmann, Erik

    2009-01-01

    Purpose of this paper: The paper researches the linkages between corporate and supply chain strategy. It represents a stage of an on-going research initiative aimed at providing a framework for understanding systematically the integration of corporate strategy making and supply chain management. Design/methodology/approach: The paper engaged itself in the theory/literature related to strategic and supply chain management. Four generic levels of strategy are linked to supply chain ma...

  18. Linking snowpack microphysics and albedo evolution

    OpenAIRE

    Mark G. Flanner; Zender, Charles S

    2006-01-01

     Snow aging causes reflectance to vary significantly on timescales of days. This variability influences the strength of snow albedo feedback and can affect the timing of snowmelt. However, climate models have yet to incorporate important controls on snow aging and albedo evolution. We develop a physically based model that predicts evolution of dry, pure snow specific surface area, and apply aspherical ice particle theory to link these results with albedo evolution. This is the first theoretic...

  19. Language-integrated provenance in Links

    OpenAIRE

    Cheney, James; Fehrenbach, Stefan

    2015-01-01

    Today’s programming languages provide no support for data provenance. In a world that increasingly relies on data, we need provenance to judge the reliability of data and therefore should aim for making it easily accessible to programmers. We report our work in progress on an extension to the Links programming language that builds on its support for language-integrated query to support where-provenance queries through query rewriting and a type system extension that distinguishes provenance m...

  20. Thermal Analyse sof Cross-Linked Polyethylene

    Directory of Open Access Journals (Sweden)

    Radek Polansky

    2007-01-01

    Full Text Available The paper summarizes results obtained during the structural analyses measurements (Differential Scanning Calorimetry DSC, Thermogravimetry TG, Thermomechanical analysis TMA and Fourier transform infrared spectroscopy FT-IR. The samples of cross-linked polyethylene cable insulation were tested via these analyses. The DSC and TG were carried out using simultaneous thermal analyzer TA Instruments SDT Q600 with connection of Fourier transform infrared spectrometer Nicolet 380. Thermomechanical analysis was carried out by TMA Q400EM TA Instruments apparatus.

  1. Improving TCP Performance over Wireless Links Using Link-Layer Retransmission and Explicit Loss Notification

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In order to support the mobility of computers during communication, the transport control protocol (TCP) con-nections between fixed host and mobile host often traverse wired and wireless networks, and the recovery of the losses dueto wireless transmission error is much different from congestion control. This paper analyzes the interaction between TCPand link layer retransmission scheme when the correlated packet are losses handled, indicates that a higher value of themaximum number of successive link layer timeout retransmissions has an adverse effect on TCP ability to perform conges-tion control rapidly. To achieve a better TCP performance, the paper proposes a strategy combining link-layer selective-re-ject automatic repeat request (ARQ) with explicit loss notification mechanism, which can respond to congestion quicklywhile keeping wireless link more reliable, and make TCP react to the different packet losses more suitably.

  2. Chloroacetamide-Linked Nucleotides and DNA for Cross-Linking with Peptides and Proteins.

    Science.gov (United States)

    Olszewska, Agata; Pohl, Radek; Brázdová, Marie; Fojta, Miroslav; Hocek, Michal

    2016-09-21

    Nucleotides, 2'-deoxyribonucleoside triphosphates (dNTPs), and DNA probes bearing reactive chloroacetamido group linked to nucleobase (cytosine or 7-deazadaenine) through a propargyl tether were prepared and tested in cross-linking with cysteine- or histidine-containing peptides and proteins. The chloroacetamide-modifed dNTPs proved to be good substrates for DNA polymerases in the enzymatic synthesis of modified DNA probes. Modified nucleotides and DNA reacted efficiently with cysteine and cysteine-containing peptides, whereas the reaction with histidine was sluggish and low yielding. The modified DNA efficiently cross-linked with p53 protein through alkylation of cysteine and showed potential for cross-linking with histidine (in C277H mutant of p53).

  3. Empathy and autobiographical memory: are they linked?

    Science.gov (United States)

    Tani, Franca; Peterson, Carole; Smorti, Andrea

    2014-01-01

    Autobiographical memory and empathy have been linked with social interaction variables as well as gender in independent bodies of literature. However a scarcity of research exists on the direct link between autobiographical memory and empathy. Exploring this link, in particular for memory of friendships and empathy, was the authors' main aim. A total of 107 Italian undergraduates participated. A memory fluency task was used to assess accessibility of memories spanning their entire life (preschool through university) and an empathy scale (Italian version of the Interpersonal Reactivity Index) was employed to measure the participants' level and dimensions of empathy. For men, empathy scores were related to how many memories they could recall. Specifically, men with higher scores on the fantasy and empathic concern scales and those with lower scores on the personal distress scales recalled more memories of friends. However, affective quality of their memories was unrelated to empathy. In contrast, for women there was no relationship between number of memories and empathy, but the emotional tone of their memories was related to empathy: those with higher scores on the personal distress scale had proportionately fewer affectively positive memories. Results are discussed in terms of gender differences in both empathy and parental socialization patterns. PMID:25175530

  4. Collagen cross-linking in thin corneas

    Directory of Open Access Journals (Sweden)

    Prema Padmanabhan

    2013-01-01

    Full Text Available Collagen cross-linking (CXL has become the standard of care for progressive keratoconus, after numerous clinical studies have established its efficacy and safety in suitably selected eyes. The standard protocol is applicable in eyes which have a minimum corneal thickness of 400 μm after epithelial debridement. This prerequisite was stipulated to protect the corneal endothelium and intraocular tissues from the deleterious effect of ultraviolet-A (UVA radiation. However, patients with keratoconus often present with corneal thickness of less than 400 μm and could have otherwise benefited from this procedure. A few modifications of the standard procedure have been suggested to benefit these patients without a compromise in safety. Transepithelial cross-linking, pachymetry-guided epithelial debridement before cross-linking, and the use of hypoosmolar riboflavin are some of the techniques that have been attempted. Although clinical data is limited at the present time, these techniques are worth considering in patients with thin corneas. Further studies are needed to scientifically establish their efficacy and safety.

  5. Link lengths and their growth powers

    International Nuclear Information System (INIS)

    For a certain infinite family F of knots or links, we study the growth power ratios of their stick number, lattice stick number, minimum lattice length and minimum ropelength compared with their minimum crossing number c(K) for every K∈F. It is known that the stick number and lattice stick number grow between the (1/2) and linear power of the crossing number, and minimum lattice length and minimum ropelength grow with at least the (3/4) power of crossing number (which is called the four-thirds power law). Furthermore, the minimal lattice length and minimum ropelength grow at most as O (c(K)[ln(c(K))]5), but it is unknown whether any family exhibits superlinear growth. For any real number r between (1/2) and 1, we give an infinite family of non-splittable prime links in which the stick number and lattice stick number grow exactly as the rth power of crossing number. Furthermore for any real number r between (3/4) and 1, we give another infinite family of non-splittable prime links in which the minimum lattice length and minimum ropelength grow exactly as the rth power of crossing number. (paper)

  6. Local Community Detection Using Link Similarity

    Institute of Scientific and Technical Information of China (English)

    Ying-Jun Wu; Han Huang; Zhi-Feng Hao; Feng Chen

    2012-01-01

    Exploring local community structure is an appealing problem that has drawn much recent attention in the area of social network analysis.As the complete information of network is often difficult to obtain,such as networks of web pages,research papers and Facebook users,people can only detect community structure from a certain source vertex with limited knowledge of the entire graph.The existing approaches do well in measuring the community quality,but they are largely dependent on source vertex and putting too strict policy in agglomerating new vertices.Moreover,they have predefined parameters which are difficult to obtain.This paper proposes a method to find local community structure by analyzing link similarity between the community and the vertex.Inspired by the fact that elements in the same community are more likely to share common links,we explore community structure heuristically by giving priority to vertices which have a high link similarity with the community.A three-phase process is also used for the sake of improving quality of community structure.Experimental results prove that our method performs effectively not only in computer-generated graphs but also in real-world graphs.

  7. Conditioned reinforcement dynamics in three-link chained schedules.

    OpenAIRE

    Williams, B.A.

    1997-01-01

    In two experiments rats were trained on three-link concurrent-chains schedules of reinforcement. In Experiment 1, additional entries to one terminal link were added during one of the middle links to a baseline schedule that was otherwise equal for the two chains, and, depending on the condition, these additional terminal-link presentations ended either in food or in no food. When food occurred, preference was always in favor of the chain with the additional terminal-link presentations (which ...

  8. Active semi-supervised community detection based on must-link and cannot-link constraints.

    Directory of Open Access Journals (Sweden)

    Jianjun Cheng

    Full Text Available Community structure detection is of great importance because it can help in discovering the relationship between the function and the topology structure of a network. Many community detection algorithms have been proposed, but how to incorporate the prior knowledge in the detection process remains a challenging problem. In this paper, we propose a semi-supervised community detection algorithm, which makes full utilization of the must-link and cannot-link constraints to guide the process of community detection and thereby extracts high-quality community structures from networks. To acquire the high-quality must-link and cannot-link constraints, we also propose a semi-supervised component generation algorithm based on active learning, which actively selects nodes with maximum utility for the proposed semi-supervised community detection algorithm step by step, and then generates the must-link and cannot-link constraints by accessing a noiseless oracle. Extensive experiments were carried out, and the experimental results show that the introduction of active learning into the problem of community detection makes a success. Our proposed method can extract high-quality community structures from networks, and significantly outperforms other comparison methods.

  9. Use of link to mammography screening information and link sharing strategies

    DEFF Research Database (Denmark)

    Mukai, Thomas; Bro, Flemming; Olesen, Frede;

    2011-01-01

    Introduction: The Internet is increasingly being used for disseminating knowledge in health care. Often this is done through a ‘Uniform Resource Locator’ (URL), better known as a link. There are three ways of sharing a link: verbally, in print or electronically. Furthermore, timing and exposure....... In addition to this, GPs in group 2 received an e-mail with the link at the midpoint of the programme. In addition to what the other two groups received, group 3 received an e-mail with the link two days after the letter. A paper-based survey of the use of the link was conducted among the 330 involved GPs....... Results: In total, 242 (73%) GPs returned the questionnaire. The mean age of the respondents was 54 years (36-70 years), and 63% were men. The proportion of GPs who used the link from the paper letter was 22% (95% CI: 17-27%). When inserted into the electronic test result sent to the GP, 37% (95% CI: 31...

  10. Challenges and Usage of Link Mining to Semantic Web

    Directory of Open Access Journals (Sweden)

    Zaved Akhtar

    2012-03-01

    Full Text Available - It is an emerging challenge for data mining is the problem of mining richly structures datasets, where the objects are linked in some way. Links among the objects may demonstrate certain patterns, which can be helpful for many data mining tasks and are usually hard to capture with traditional statistical models. Many datasets of interest today are best described as a linked collection of interrelated objects. These may represent homogeneous networks, in which there is a single-object type and link type (eg. people connected by friendship links, or the WWW, a collection of linked web pages or richer, heterogeneous networks, in which there may be multiple object and link types (and possibly other semantic information. Examples of heterogeneous networks include those in medical domains describing patients, diseases, treatments and contacts, or in bibliographic domains describing publications, authors, and venues. Link mining refers to data mining techniques that explicitly consider these links when building predictive or descriptive models of the linked data. Commonly addressed link mining tasks include object ranking, group detection, collective classification, link prediction and subgraph discovery. This is an exciting and rapidly expanding area. In this article we review some of the common emerging themes and discuss ongoing link mining challenges; open issues and suggest ideas that could be opportunities for solutions. The most conclusion of this article is that providing an idea to usage link mining techniques from link mining to help to construct the Semantic Web.

  11. Optimisation of the link volume for weakest link failure prediction in NBG-18 nuclear graphite

    Energy Technology Data Exchange (ETDEWEB)

    Hindley, Michael P., E-mail: makke@mweb.co.za [Pebble Bed Modular Reactor (Pty) Ltd., PO Box 12271, Centurion 0046 (South Africa); Groenwold, Albert A.; Blaine, Deborah C.; Becker, Thorsten H. [Department of Mechanical and Mechatronic Engineering, Stellenbosch University, Private Bag X1, Matieland 7602 (South Africa)

    2014-07-01

    This paper describes the process for approximating the optimal size of a link volume required for weakest link failure calculation in nuclear graphite, with NBG-18 used as an example. As part of the failure methodology, the link volume is defined in terms of two grouping criteria. The first criterion is a factor of the maximum grain size and the second criterion is a function of an equivalent stress limit. A methodology for approximating these grouping criteria is presented. The failure methodology employs finite element analysis (FEA) in order to predict the failure load, at 50% probability of failure. The average experimental failure load, as determined for 26 test geometries, is used to evaluate the accuracy of the weakest link failure calculations. The influence of the two grouping criteria on the failure load prediction is evaluated by defining an error in prediction across all test cases. Mathematical optimisation is used to find the minimum error across a range of test case failure predictions. This minimum error is shown to deliver the most accurate failure prediction across a whole range of components, although some test cases in the range predict conservative failure load. The mathematical optimisation objective function is penalised to account for non-conservative prediction of the failure load for any test case. The optimisation is repeated and a link volume found for conservative failure prediction. The failure prediction for each test case is evaluated, in detail, for the proposed link volumes. Based on the analysis, link design volumes for NBG-18 are recommended for either accurate or conservative failure prediction.

  12. Optical links in handheld multimedia devices

    Science.gov (United States)

    van Geffen, S.; Duis, J.; Miller, R.

    2008-04-01

    Ever emerging applications in handheld multimedia devices such as mobile phones, laptop computers, portable video games and digital cameras requiring increased screen resolutions are driving higher aggregate bitrates between host processor and display(s) enabling services such as mobile video conferencing, video on demand and TV broadcasting. Larger displays and smaller phones require complex mechanical 3D hinge configurations striving to combine maximum functionality with compact building volumes. Conventional galvanic interconnections such as Micro-Coax and FPC carrying parallel digital data between host processor and display module may produce Electromagnetic Interference (EMI) and bandwidth limitations caused by small cable size and tight cable bends. To reduce the number of signals through a hinge, the mobile phone industry, organized in the MIPI (Mobile Industry Processor Interface) alliance, is currently defining an electrical interface transmitting serialized digital data at speeds >1Gbps. This interface allows for electrical or optical interconnects. Above 1Gbps optical links may offer a cost effective alternative because of their flexibility, increased bandwidth and immunity to EMI. This paper describes the development of optical links for handheld communication devices. A cable assembly based on a special Plastic Optical Fiber (POF) selected for its mechanical durability is terminated with a small form factor molded lens assembly which interfaces between an 850nm VCSEL transmitter and a receiving device on the printed circuit board of the display module. A statistical approach based on a Lean Design For Six Sigma (LDFSS) roadmap for new product development tries to find an optimum link definition which will be robust and low cost meeting the power consumption requirements appropriate for battery operated systems.

  13. Musical Preferences are Linked to Cognitive Styles.

    Science.gov (United States)

    Greenberg, David M; Baron-Cohen, Simon; Stillwell, David J; Kosinski, Michal; Rentfrow, Peter J

    2015-01-01

    Why do we like the music we do? Research has shown that musical preferences and personality are linked, yet little is known about other influences on preferences such as cognitive styles. To address this gap, we investigated how individual differences in musical preferences are explained by the empathizing-systemizing (E-S) theory. Study 1 examined the links between empathy and musical preferences across four samples. By reporting their preferential reactions to musical stimuli, samples 1 and 2 (Ns = 2,178 and 891) indicated their preferences for music from 26 different genres, and samples 3 and 4 (Ns = 747 and 320) indicated their preferences for music from only a single genre (rock or jazz). Results across samples showed that empathy levels are linked to preferences even within genres and account for significant proportions of variance in preferences over and above personality traits for various music-preference dimensions. Study 2 (N = 353) replicated and extended these findings by investigating how musical preferences are differentiated by E-S cognitive styles (i.e., 'brain types'). Those who are type E (bias towards empathizing) preferred music on the Mellow dimension (R&B/soul, adult contemporary, soft rock genres) compared to type S (bias towards systemizing) who preferred music on the Intense dimension (punk, heavy metal, and hard rock). Analyses of fine-grained psychological and sonic attributes in the music revealed that type E individuals preferred music that featured low arousal (gentle, warm, and sensual attributes), negative valence (depressing and sad), and emotional depth (poetic, relaxing, and thoughtful), while type S preferred music that featured high arousal (strong, tense, and thrilling), and aspects of positive valence (animated) and cerebral depth (complexity). The application of these findings for clinicians, interventions, and those on the autism spectrum (largely type S or extreme type S) are discussed. PMID:26200656

  14. Musical Preferences are Linked to Cognitive Styles.

    Science.gov (United States)

    Greenberg, David M; Baron-Cohen, Simon; Stillwell, David J; Kosinski, Michal; Rentfrow, Peter J

    2015-01-01

    Why do we like the music we do? Research has shown that musical preferences and personality are linked, yet little is known about other influences on preferences such as cognitive styles. To address this gap, we investigated how individual differences in musical preferences are explained by the empathizing-systemizing (E-S) theory. Study 1 examined the links between empathy and musical preferences across four samples. By reporting their preferential reactions to musical stimuli, samples 1 and 2 (Ns = 2,178 and 891) indicated their preferences for music from 26 different genres, and samples 3 and 4 (Ns = 747 and 320) indicated their preferences for music from only a single genre (rock or jazz). Results across samples showed that empathy levels are linked to preferences even within genres and account for significant proportions of variance in preferences over and above personality traits for various music-preference dimensions. Study 2 (N = 353) replicated and extended these findings by investigating how musical preferences are differentiated by E-S cognitive styles (i.e., 'brain types'). Those who are type E (bias towards empathizing) preferred music on the Mellow dimension (R&B/soul, adult contemporary, soft rock genres) compared to type S (bias towards systemizing) who preferred music on the Intense dimension (punk, heavy metal, and hard rock). Analyses of fine-grained psychological and sonic attributes in the music revealed that type E individuals preferred music that featured low arousal (gentle, warm, and sensual attributes), negative valence (depressing and sad), and emotional depth (poetic, relaxing, and thoughtful), while type S preferred music that featured high arousal (strong, tense, and thrilling), and aspects of positive valence (animated) and cerebral depth (complexity). The application of these findings for clinicians, interventions, and those on the autism spectrum (largely type S or extreme type S) are discussed.

  15. Musical Preferences are Linked to Cognitive Styles.

    Directory of Open Access Journals (Sweden)

    David M Greenberg

    Full Text Available Why do we like the music we do? Research has shown that musical preferences and personality are linked, yet little is known about other influences on preferences such as cognitive styles. To address this gap, we investigated how individual differences in musical preferences are explained by the empathizing-systemizing (E-S theory. Study 1 examined the links between empathy and musical preferences across four samples. By reporting their preferential reactions to musical stimuli, samples 1 and 2 (Ns = 2,178 and 891 indicated their preferences for music from 26 different genres, and samples 3 and 4 (Ns = 747 and 320 indicated their preferences for music from only a single genre (rock or jazz. Results across samples showed that empathy levels are linked to preferences even within genres and account for significant proportions of variance in preferences over and above personality traits for various music-preference dimensions. Study 2 (N = 353 replicated and extended these findings by investigating how musical preferences are differentiated by E-S cognitive styles (i.e., 'brain types'. Those who are type E (bias towards empathizing preferred music on the Mellow dimension (R&B/soul, adult contemporary, soft rock genres compared to type S (bias towards systemizing who preferred music on the Intense dimension (punk, heavy metal, and hard rock. Analyses of fine-grained psychological and sonic attributes in the music revealed that type E individuals preferred music that featured low arousal (gentle, warm, and sensual attributes, negative valence (depressing and sad, and emotional depth (poetic, relaxing, and thoughtful, while type S preferred music that featured high arousal (strong, tense, and thrilling, and aspects of positive valence (animated and cerebral depth (complexity. The application of these findings for clinicians, interventions, and those on the autism spectrum (largely type S or extreme type S are discussed.

  16. Linking microarray reporters with protein functions

    Directory of Open Access Journals (Sweden)

    Gaj Stan

    2007-09-01

    Full Text Available Abstract Background The analysis of microarray experiments requires accurate and up-to-date functional annotation of the microarray reporters to optimize the interpretation of the biological processes involved. Pathway visualization tools are used to connect gene expression data with existing biological pathways by using specific database identifiers that link reporters with elements in the pathways. Results This paper proposes a novel method that aims to improve microarray reporter annotation by BLASTing the original reporter sequences against a species-specific EMBL subset, that was derived from and crosslinked back to the highly curated UniProt database. The resulting alignments were filtered using high quality alignment criteria and further compared with the outcome of a more traditional approach, where reporter sequences were BLASTed against EnsEMBL followed by locating the corresponding protein (UniProt entry for the high quality hits. Combining the results of both methods resulted in successful annotation of > 58% of all reporter sequences with UniProt IDs on two commercial array platforms, increasing the amount of Incyte reporters that could be coupled to Gene Ontology terms from 32.7% to 58.3% and to a local GenMAPP pathway from 9.6% to 16.7%. For Agilent, 35.3% of the total reporters are now linked towards GO nodes and 7.1% on local pathways. Conclusion Our methods increased the annotation quality of microarray reporter sequences and allowed us to visualize more reporters using pathway visualization tools. Even in cases where the original reporter annotation showed the correct description the new identifiers often allowed improved pathway and Gene Ontology linking. These methods are freely available at http://www.bigcat.unimaas.nl/public/publications/Gaj_Annotation/.

  17. Key agreement over a radio link

    OpenAIRE

    Cagalj, Mario; Hubaux, Jean-Pierre

    2004-01-01

    We present a simple, and yet powerful, technique for key establishment over a radio link in peer-to-peer networks. Our approach is based on the Diffie-Hellman key agreement protocol. This protocol is known to be vulnerable to the ``man-in-the-middle" attack if two users involved in the protocol share no authenticated information about each other (e.g., public keys) prior to the protocol execution. In this work, we show how the natural ability of users to authenticate each other by visual and ...

  18. Linked Ocean Data 2.0

    Science.gov (United States)

    Shepherd, Adam; Leadbetter, Adam; Cheatham, Michelle; Thomas, Rob

    2016-04-01

    When considering sustainable development of the oceans, it is not desirable to either have data siloed in one location where it cannot be reused for purposes beyond which it was originally collected, or in a state where it cannot be integrated into an holistic view of the marine environment. As such, the links between datasets should be formally documented and exploited as best as possible. Given this, the use of Semantic Web technology and information modelling patterns are explored with reference to the marine domain. Further, new strategies for adding semantic annotation to data in real-time are discussed and prototyped.

  19. Sharp Connection: Linking Competitive Intelligence and Intranets

    OpenAIRE

    Hendriks, P.H.J.; Jacobs, W.H.

    2003-01-01

    Assessing the value of ICT to support Competitive Intelligence presumes an understanding of the relationship between the two. The chapter argues that starting from either the ICT or CI side to this relationship and linking to the other, as most studies do, cannot secure a fully adequate conception of ICT’s value to CI. Instead, the challenge is to find an appropriate foundation in the relationship itself and use it as a stepping stone for developing an understanding of both ICT and CI. The ch...

  20. Cross-linking for microbial keratitis

    Directory of Open Access Journals (Sweden)

    Jayesh Vazirani

    2013-01-01

    Full Text Available The success of collagen cross-linking as a clinical modality to modify the clinical course in keratoconus seems to have fueled the search for alternative applications for this treatment. Current clinical data on its efficacy is limited and laboratory data seems to indicate that it performs poorly against resistant strains of bacteria and against slow growing organisms. However, the biological plausibility of crosslinking and the lack of effective strategies in managing infections with these organisms continue to focus attention on this potential treatment. Well-conducted experimental and clinical studies with controls are required to answer the questions of its efficacy in future.

  1. Singularity links with exotic Stein fillings

    OpenAIRE

    Özbağcı, Burak; Akhmedov, Anar

    2012-01-01

    arXiv:1206.2468v3 [math.GT] 14 May 2014 SINGULARITY LINKS WITH EXOTIC STEIN FILLINGS ANAR AKHMEDOV AND BURAK OZBAGCI ABSTRACT. In [4], it was shown that there exist infinitely many contact Seifert fibered 3-manifolds each of which admits infinitely many exotic (homeomorphic but pairwise non-diffeomorphic) simply-connected Stein fillings. Here we extend this result to a larger set of contact Seifert fibered 3-manifolds with many singular fibers and observe that these 3- ma...

  2. Links between nutrition and reproduction in cattle

    International Nuclear Information System (INIS)

    Situations in which nutrition modulates reproductive function, and targets involved, are identified, particularly in relation to initiation of cyclicity (at puberty, during the post-partum period or after induction of ovulation), fertility and induction of ovulation. The usefulness and pertinence of measurements of body weight variations, body condition score, nutritional balance or blood metabolites (glucose, ketone bodies, free fatty acids, cholesterol, urea and amino acids) to evaluate nutritional status in this context is considered. Leptin could play a central role in causal mechanisms linking nutrition and reproduction, in conjunction with somatotropic axis, insulin, opioids, and neuropeptide Y. (author)

  3. Tantalizing Thanatos: unexpected links in death pathways.

    Science.gov (United States)

    Cohen, Isabelle; Castedo, Maria; Kroemer, Guido

    2002-07-01

    Cell death is most frequently the result of apoptosis, an event that is often controlled by mitochondrial membrane permeabilization (MMP). Recent data reveal unexpected functional links between apoptosis and autophagic cell death, in the sense that MMP can trigger autophagy of damaged mitochondria. Conversely, one of the major signal-transducing molecules involved in the activation of autophagy during apoptosis--the so-called DAP kinase--can induce cell death through MMP. Connections are also emerging between apoptosis, autophagy, replicative senescence and cancer-specific metabolic changes. PMID:12185842

  4. An optical communication link on the Shuttle

    Science.gov (United States)

    Grady, Jane L.

    A communication link for the transfer of data between the crew cabin and payload bay of the Shuttle is proposed. The configuration of the system, which is to transmit data optically through the Shuttle cabin window, is described. The effects of temperature cycling and cosmic radiation on optical fibers, the cable, connectors, and lenses, and of vibrations during a mission on the alignment of collimating lenses at the window are investigated. Consideration is given to determining the optimum design for the optical fiber and the optimum system operation wavelength for transmission through the aft Orbiter window and the payload environment.

  5. Bidirectional ROF Links with Dynamic Capacity Allocation

    Directory of Open Access Journals (Sweden)

    Rakesh Kumar Chandan , Dharmendra Singh

    2013-10-01

    Full Text Available : Radio over fiber (ROF technology is an integration of wireless and fiber optic network. It plays vital role for broad band wireless communication. The well known advantages of optical as a transmission medium such as low loss, light weight, large bandwidth characteristics, small size and low cable cost make it the ideal and most flexible solution for efficiently transporting radio signals to remotely located antenna site in a wireless network. The joint venture of radio signal and optical fiber technology provides dynamic capacity allocation in radio over fiber links.

  6. Term Bases and Linguistic Linked Open Data

    DEFF Research Database (Denmark)

    for pursuing their work. The theme of this year’s TKE is ‘Term Bases and Linguistic Linked Open Data’. Mono- and multi-lingual term bases, which contain information about concepts (terms, definitions, examples of use, references, comments on equivalence etc.), have always made up valuable linguistic resources....... Today, some terminology and knowledge bases combine traditional term bases and terminological ontologies, where concepts are related by means of various types of concept relations, and are further described by means of characteristics....

  7. Link Label Prediction in Signed Citation Network

    KAUST Repository

    Akujuobi, Uchenna

    2016-04-12

    Link label prediction is the problem of predicting the missing labels or signs of all the unlabeled edges in a network. For signed networks, these labels can either be positive or negative. In recent years, different algorithms have been proposed such as using regression, trust propagation and matrix factorization. These approaches have tried to solve the problem of link label prediction by using ideas from social theories, where most of them predict a single missing label given that labels of other edges are known. However, in most real-world social graphs, the number of labeled edges is usually less than that of unlabeled edges. Therefore, predicting a single edge label at a time would require multiple runs and is more computationally demanding. In this thesis, we look at link label prediction problem on a signed citation network with missing edge labels. Our citation network consists of papers from three major machine learning and data mining conferences together with their references, and edges showing the relationship between them. An edge in our network is labeled either positive (dataset relevant) if the reference is based on the dataset used in the paper or negative otherwise. We present three approaches to predict the missing labels. The first approach converts the label prediction problem into a standard classification problem. We then, generate a set of features for each edge and then adopt Support Vector Machines in solving the classification problem. For the second approach, we formalize the graph such that the edges are represented as nodes with links showing similarities between them. We then adopt a label propagation method to propagate the labels on known nodes to those with unknown labels. In the third approach, we adopt a PageRank approach where we rank the nodes according to the number of incoming positive and negative edges, after which we set a threshold. Based on the ranks, we can infer an edge would be positive if it goes a node above the

  8. Characterization of Cross-Linked Lipase Aggregates

    DEFF Research Database (Denmark)

    Prabhavathi Devi, Bethala Lakshmi Anu; Guo, Zheng; Xu, Xuebing

    2009-01-01

    Commercially available microbial lipases from different sources were immobilized as cross-linked enzyme aggregates (CLEAs) using different precipitants and glutaraldehyde as cross-linkers. These CLEAs were assayed based on esterification between lauric acid and n-propanol in solvent-free systems....... Precipitants were found to have a profound influence on both specific activities and total activity recovery of CLEAs, as exemplified by Candida antarctica lipase B (CALB). Among the CLEAs of CALB studied, those obtained using PEG600, ammonium sulfate, PEG200 and acetone as precipitants were observed to attain...

  9. Crafting Linked Open Data for Cultural Heritage: Mapping and Curation Tools for the Linked Jazz Project

    Directory of Open Access Journals (Sweden)

    M. Cristina Pattuelli

    2013-07-01

    Full Text Available This paper describes tools and methods developed as part of Linked Jazz, a project that uses Linked Open Data (LOD to reveal personal and professional relationships among jazz musicians based on interviews from jazz archives. The overarching aim of Linked Jazz is to explore the possibilities offered by LOD to enhance the visibility of cultural heritage materials and enrich the semantics that describe them. While the full Linked Jazz dataset is still under development, this paper presents two applications that have laid the foundation for the creation of this dataset: the Mapping and Curator Tool, and the Transcript Analyzer. These applications have served primarily for data preparation, analysis, and curation and are representative of the types of tools and methods needed to craft linked data from digital content available on the web. This paper discusses these two domain-agnostic tools developed to create LOD from digital textual documents and offers insight into the process behind the creation of LOD in general.

  10. Research on common issues for relationship between mechanism degree of freedom, driving link and executive link

    Institute of Scientific and Technical Information of China (English)

    WANG AiLun

    2009-01-01

    During engineering practice and theoretical research, the mechanism degree of freedom is sometimes unequal to the number of the driving link, which is unable to be explained according to the classic theory of the mechanism degree of freedom. To solve this problem, the duality description for operating laws of mechanism is introduced based on the concepts of duality. The Junction-Structure Equation is established for the port descriptions of general ideal mechanism and the functional description for the mechanism degree of freedom is described by utilization of bond graph theory. The force-transfer degree of freedom, i.e. the antithesis concept of movement-transfer degree of freedom, is introduced and defined based on the analysis of energy transfer as well as the analysis of signal causality. By utilization of structural description, functional description and duality description for the equation of degree of freedom, the relationship between the movement-transfer degree of freedom and force-transfer degree of freedom is further explored and analyzed. Thus, the relationship between the mechanism degree of freedom upon the driving link and the executive link is described generally. Finally, some typical relationships between the mechanism degree of freedom, the driving link and the executive link are analyzed.

  11. Spatial-Operator Algebra For Flexible-Link Manipulators

    Science.gov (United States)

    Jain, Abhinandan; Rodriguez, Guillermo

    1994-01-01

    Method of computing dynamics of multiple-flexible-link robotic manipulators based on spatial-operator algebra, which originally applied to rigid-link manipulators. Aspects of spatial-operator-algebra approach described in several previous articles in NASA Tech Briefs-most recently "Robot Control Based on Spatial-Operator Algebra" (NPO-17918). In extension of spatial-operator algebra to manipulators with flexible links, each link represented by finite-element model: mass of flexible link apportioned among smaller, lumped-mass rigid bodies, coupling of motions expressed in terms of vibrational modes. This leads to operator expression for modal-mass matrix of link.

  12. Improving interdependent networks robustness by adding connectivity links

    Science.gov (United States)

    Ji, Xingpei; Wang, Bo; Liu, Dichen; Chen, Guo; Tang, Fei; Wei, Daqian; Tu, Lian

    2016-02-01

    Compared with a single and isolated network, interdependent networks have two types of links: connectivity link and dependency link. This paper aims to improve the robustness of interdependent networks by adding connectivity links. Firstly, interdependent networks failure model and four frequently used link addition strategies are briefly reviewed. Furthermore, by defining inter degree-degree difference, two novel link addition strategies are proposed. Finally, we verify the effectiveness of our proposed link addition strategies by comparing with the current link addition strategies in three different network models. The simulation results show that, given the number of added links, link allocation strategies have great effects on the robustness of interdependent networks, i.e., the double-network link allocation strategy is superior to single-network link allocation strategy. Link addition strategies proposed in this paper excel the current strategies, especially for BA interdependent networks. Moreover, our work can provide guidance on how to allocate limited resources to an existing interdependent networks system and optimize its topology to avoid the potential cascade failures.

  13. Alpha thalassaemia-mental retardation, X linked

    Directory of Open Access Journals (Sweden)

    Gibbons Richard

    2006-05-01

    Full Text Available Abstract X-linked alpha thalassaemia mental retardation (ATR-X syndrome in males is associated with profound developmental delay, facial dysmorphism, genital abnormalities and alpha thalassaemia. Female carriers are usually physically and intellectually normal. So far, 168 patients have been reported. Language is usually very limited. Seizures occur in about one third of the cases. While many patients are affectionate with their caregivers, some exhibit autistic-like behaviour. Patients present with facial hypotonia and a characteristic mouth. Genital abnormalities are observed in 80% of children and range from undescended testes to ambiguous genitalia. Alpha-thalassaemia is not always present. This syndrome is X-linked recessive and results from mutations in the ATRX gene. This gene encodes the widely expressed ATRX protein. ATRX mutations cause diverse changes in the pattern of DNA methylation at heterochromatic loci but it is not yet known whether this is responsible for the clinical phenotype. The diagnosis can be established by detection of alpha thalassaemia, identification of ATRX gene mutations, ATRX protein studies and X-inactivation studies. Genetic counselling can be offered to families. Management is multidisciplinary: young children must be carefully monitored for gastro-oesophageal reflux as it may cause death. A number of individuals with ATR-X are fit and well in their 30s and 40s.

  14. Links between circadian rhythms and psychiatric disease

    Directory of Open Access Journals (Sweden)

    Ilia N Karatsoreos

    2014-05-01

    Full Text Available Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will hopefully lead to the discovery of treatments to either prevent or alleviate the suffering caused by these diseases. One roadblock to attaining this goal is the realization that neuropsychiatric diseases are rarely due to a single gene polymorphism, environmental exposure, or developmental insult. Rather, it is a complex interaction between these various influences that likely leads to the development of clinically relevant syndromes. Our lab is exploring the links between environmental exposures and neurobehavioral function by investigating how disruption of the circadian (daily clock alters the structure and function of neural circuits, with the hypothesis that disrupting this crucial homeostatic system can directly contribute to altered vulnerability of the organism to other factors that interact to produce psychiatric illness. This review explores some historical and more recent findings that link disrupted circadian clocks to neuropsychiatric disorders, particularly depression, mania, and schizophrenia. We take a comparative approach by exploring the effects observed in human populations, as well as some experimental models used in the laboratory to unravel mechanistic and causal relationships between disruption of the circadian clock and behavioral abnormalities. This is a rich area of research that we predict will contribute greatly to our understanding of how genes, environment, and development interact to modulate an individual’s vulnerability to psychiatric disorders.

  15. [The link between obesity and cancer].

    Science.gov (United States)

    Sánchez R, César; Ibáñez, Carolina; Klaassen, Julieta

    2014-02-01

    While some genetic factors may explain the development of cancer, its main causes are related to environmental exposure to carcinogenic agents as well as to the effect of determined lifestyles and habits. Several epidemiological studies have shown a consistent relation between obesity and cancer. In non smokers, obesity is the most relevant risk factor in the development of malignant tumors. There is a clear association between obesity and endometrial cancer, breast cancer in postmenopausal women, pancreatic, esophageal and colon cancer. Sexual steroids, insulin like growth factor axis and adipokines are the three main models to explain the biological basis for the obesity-cancer relationship. However, these models do not explain all the biological mechanisms that link obesity to cancer. There are other factors in play such as chronic inflammation, hypoxia and oxidative stress. Obesity may hamper the screening, diagnosis and treatment of some tumors, increasing mortality rates. Obesity prevention and management, therefore, may be the most important modifiable factor in reducing both incidence and mortality in cancer. New studies are required to quantify the effect of intentional weight reduction on the incidence and relapse of cancer. Considering the efficacy of bariatric surgery for weight reduction, it is an attractive model to study this link.

  16. Harm mediates the disgust-immorality link.

    Science.gov (United States)

    Schein, Chelsea; Ritter, Ryan S; Gray, Kurt

    2016-09-01

    Many acts are disgusting, but only some of these acts are immoral. Dyadic morality predicts that disgusting acts should be judged as immoral to the extent that they seem harmful. Consistent with this prediction, 3 studies reveal that perceived harm mediates the link between feelings of disgust and moral condemnation-even for ostensibly harmless "purity" violations. In many cases, accounting for perceived harm completely eliminates the link between disgust and moral condemnation. Analyses also reveal the predictive power of anger and typicality/weirdness in moral judgments of disgusting acts. The mediation of disgust by harm holds across diverse acts including gay marriage, sex acts, and religious blasphemy. Revealing the endogenous presence and moral relevance of harm within disgusting-but-ostensibly harmless acts argues against modular accounts of moral cognition such as moral foundations theory. Instead, these data support pluralistic conceptions of harm and constructionist accounts of morality and emotion. Implications for moral cognition and the concept of "purity" are discussed. (PsycINFO Database Record PMID:27100369

  17. Linking ecosystem processes to sustainable wetland management

    Science.gov (United States)

    Euliss, Ned H.; Smith, Loren M.; Wilcox, Douglas A.; Browne, Bryant A.

    2009-01-01

    As a result of concern over problems associated with the future of managed wetlands in North America, nearly two dozen wetland scientists and managers met in February 2006 at Bosque del Apache National Wildlife Refuge in New Mexico and discussed a sustainable approach to wetland management. This approach links science with management by focusing on underlying wetland processes. From that meeting, several papers were developed and published in Wetlands to address these concerns (Euliss et al. 2008, Smith et al. 2008, Wilcox 2008). This article summarizes our first paper, Euliss et al. (2008), and a future Newsletter article will summarize Smith et al. (2008). Realization of the role that complex interactions play in maintaining ecosystems, coupled with increasing demands of humans for ecosystem services, has prompted much interest in ecosystem management. Not surprisingly, sustainability of ecosystems has become an explicitly stated goal of many natural resource agencies and, in some cases, has been legislatively mandated to ensure provision of resources for future generations. However, examples of sustainable ecosystem management are uncommon because management goals often focus on specific deliverables rather than processes that sustain ecosystems. This paper has three sections: (1) perspectives in which we provide a bit of history, (2), ecological consequences of a static view, and (3) suggestions to aid wetland managers link management goals with critical ecosystem processes responsible for provision of wetland services.

  18. Nutrition education: linking research, theory, and practice.

    Science.gov (United States)

    Contento, Isobel R

    2008-01-01

    The increase in obesity and chronic diseases such as diabetes and heart disease worldwide reflects the complex interactions of biology, personal behaviour and environment. Consequently there has been a greater recognition of the importance of nutrition education. An analysis of the evidence from 300+ studies shows that nutrition education is more likely to be effective when it focuses on behaviour/ action (rather than knowledge only) and systematically links theory, research and practice. There are three essential components to nutrition education: 1. A motivational component, where the goal is to increase awareness and enhance motivation by addressing beliefs, attitudes through effective communication strategies. 2. An action component, where the goal is to facilitate people's ability to take action through goal setting and cognitive self-regulation skills. 3. An environmental component, where nutrition educators work with policymakers and others to promote environmental supports for action. Each component needs to be based on appropriate theory and research. The procedure for program design can use the logic model: Inputs are the resources needed as well as the needs analysis process. The outputs are the activities within the three components of nutrition education described above. Here the behavioural focus is selected and theory and research are used to design appropriate educational strategies to achieve the targeted behaviours. The outcomes are the short, medium or long-term impacts of the nutrition program. These are evaluated through the use of appropriate designs and instruments. Nutrition education programs that link research, theory, and practice are more likely to be effective.

  19. Porting Inition and Failure to Linked Cheetah

    Energy Technology Data Exchange (ETDEWEB)

    Vitello, P; Souers, P C

    2007-07-18

    Linked CHEETAH is a thermo-chemical code coupled to a 2-D hydrocode. Initially, a quadratic-pressure dependent kinetic rate was used, which worked well in modeling prompt detonation of explosives of large size, but does not work on other aspects of explosive behavior. The variable-pressure Tarantula reactive flow rate model was developed with JWL++ in order to also describe failure and initiation, and we have moved this model into Linked CHEETAH. The model works by turning on only above a pressure threshold, where a slow turn-on creates initiation. At a higher pressure, the rate suddenly leaps to a large value over a small pressure range. A slowly failing cylinder will see a rapidly declining rate, which pushes it quickly into failure. At a high pressure, the detonation rate is constant. A sequential validation procedure is used, which includes metal-confined cylinders, rate-sticks, corner-turning, initiation and threshold, gap tests and air gaps. The size (diameter) effect is central to the calibration.

  20. Parkinson's Disease: The Mitochondria-Iron Link.

    Science.gov (United States)

    Muñoz, Yorka; Carrasco, Carlos M; Campos, Joaquín D; Aguirre, Pabla; Núñez, Marco T

    2016-01-01

    Mitochondrial dysfunction, iron accumulation, and oxidative damage are conditions often found in damaged brain areas of Parkinson's disease. We propose that a causal link exists between these three events. Mitochondrial dysfunction results not only in increased reactive oxygen species production but also in decreased iron-sulfur cluster synthesis and unorthodox activation of Iron Regulatory Protein 1 (IRP1), a key regulator of cell iron homeostasis. In turn, IRP1 activation results in iron accumulation and hydroxyl radical-mediated damage. These three occurrences-mitochondrial dysfunction, iron accumulation, and oxidative damage-generate a positive feedback loop of increased iron accumulation and oxidative stress. Here, we review the evidence that points to a link between mitochondrial dysfunction and iron accumulation as early events in the development of sporadic and genetic cases of Parkinson's disease. Finally, an attempt is done to contextualize the possible relationship between mitochondria dysfunction and iron dyshomeostasis. Based on published evidence, we propose that iron chelation-by decreasing iron-associated oxidative damage and by inducing cell survival and cell-rescue pathways-is a viable therapy for retarding this cycle.

  1. Parkinson's Disease: The Mitochondria-Iron Link.

    Science.gov (United States)

    Muñoz, Yorka; Carrasco, Carlos M; Campos, Joaquín D; Aguirre, Pabla; Núñez, Marco T

    2016-01-01

    Mitochondrial dysfunction, iron accumulation, and oxidative damage are conditions often found in damaged brain areas of Parkinson's disease. We propose that a causal link exists between these three events. Mitochondrial dysfunction results not only in increased reactive oxygen species production but also in decreased iron-sulfur cluster synthesis and unorthodox activation of Iron Regulatory Protein 1 (IRP1), a key regulator of cell iron homeostasis. In turn, IRP1 activation results in iron accumulation and hydroxyl radical-mediated damage. These three occurrences-mitochondrial dysfunction, iron accumulation, and oxidative damage-generate a positive feedback loop of increased iron accumulation and oxidative stress. Here, we review the evidence that points to a link between mitochondrial dysfunction and iron accumulation as early events in the development of sporadic and genetic cases of Parkinson's disease. Finally, an attempt is done to contextualize the possible relationship between mitochondria dysfunction and iron dyshomeostasis. Based on published evidence, we propose that iron chelation-by decreasing iron-associated oxidative damage and by inducing cell survival and cell-rescue pathways-is a viable therapy for retarding this cycle. PMID:27293957

  2. Perceptual asymmetries and handedness: A neglected link?

    Directory of Open Access Journals (Sweden)

    Daniele eMarzoli

    2014-02-01

    Full Text Available Healthy individuals tend to weigh in more the left than the right side of visual space in a variety of contexts, ranging from pseudoneglect to perceptual asymmetries for faces. Among the common explanations proposed for the attentional and perceptual advantages of the left visual field, a link with the prevalence of right-handedness in humans has never been suggested, although some evidence seems to converge in favor of a bias of spatial attention towards the region most likely coincident with another person’s right hand during a face-to-face interaction. Such a bias might imply an increased efficiency in monitoring both communicative and aggressive acts, the right limb being more used than the left in both types of behaviour. Although attentional and perceptual asymmetries could be linked to right-handedness at the level of phylogeny because of the evolutionarily advantage of directing attention towards the region where others’ dominant hand usually operates, it is also legitimate to question whether, at the ontogenetic level, frequent exposure to right-handed individuals may foster leftward biases. These views are discussed in the light of extant literature, and a number of tests are proposed in order to assess our hypotheses.

  3. Improving Link Prediction in Intermittently Connected Wireless Networks by Considering Link and Proximity Stabilities

    CERN Document Server

    Zayani, Mohamed-Haykel; Zeghlache, Djamal

    2012-01-01

    Several works have outlined the fact that the mobility in intermittently connected wireless networks is strongly governed by human behaviors as they are basically human-centered. It has been shown that the users' moves can be correlated and that the social ties shared by the users highly impact their mobility patterns and hence the network structure. Tracking these correlations and measuring the strength of social ties have led us to propose an efficient distributed tensor-based link prediction technique. In fact, we are convinced that the feedback provided by such a prediction mechanism can enhance communication protocols such as opportunistic routing protocols. In this paper, we aim to bring out that measuring the stabilities of the link and the proximity at two hops can improve the efficiency of the proposed link prediction technique. To quantify these two parameters, we propose an entropy estimator in order to measure the two stability aspects over successive time periods. Then, we join these entropy esti...

  4. Cooperative Communications. Link Reliability and Power Efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Ahsin, Tafzeel ur Rehman

    2012-07-01

    Demand for high data rates is increasing rapidly for the future wireless generations, due to the requirement of ubiquitous coverage for wireless broadband services. More base stations are needed to deliver these services, in order to cope with the increased capacity demand and inherent unreliable nature of wireless medium. However, this would directly correspond to high infrastructure cost and energy consumption in cellular networks. Nowadays, high power consumption in the network is becoming a matter of concern for the operators,both from environmental and economic point of view. Cooperative communications, which is regarded as a virtual multi-input-multi-output (MIMO) channel, can be very efficient in combating fading multi-path channels and improve coverage with low complexity and cost. With its distributed structure, cooperative communications can also contribute to the energy efficiency of wireless systems and green radio communications of the future. Using network coding at the top of cooperative communication, utilizes the network resources more efficiently. Here we look at the case of large scale use of low cost relays as a way of making the links reliable, that directly corresponds to reduction in transmission power at the nodes. A lot of research work has focused on highlighting the gains achieved by using network coding in cooperative transmissions. However, there are certain areas that are not fully explored yet. For instance, the kind of detection scheme used at the receiver and its impact on the link performance has not been addressed.The thesis looks at the performance comparison of different detection schemes and also proposes how to group users at the relay to ensure mutual benefit for the cooperating users.Using constellation selection at the nodes, the augmented space formed at the receiver is exploited for making the links more reliable. The network and the channel coding schemes are represented as a single product code, that allows us to

  5. EarthCube GeoLink: Semantics and Linked Data for the Geosciences

    Science.gov (United States)

    Arko, R. A.; Carbotte, S. M.; Chandler, C. L.; Cheatham, M.; Fils, D.; Hitzler, P.; Janowicz, K.; Ji, P.; Jones, M. B.; Krisnadhi, A.; Lehnert, K. A.; Mickle, A.; Narock, T.; O'Brien, M.; Raymond, L. M.; Schildhauer, M.; Shepherd, A.; Wiebe, P. H.

    2015-12-01

    The NSF EarthCube initiative is building next-generation cyberinfrastructure to aid geoscientists in collecting, accessing, analyzing, sharing, and visualizing their data and knowledge. The EarthCube GeoLink Building Block project focuses on a specific set of software protocols and vocabularies, often characterized as the Semantic Web and "Linked Data", to publish data online in a way that is easily discoverable, accessible, and interoperable. GeoLink brings together specialists from the computer science, geoscience, and library science domains, and includes data from a network of NSF-funded repositories that support scientific studies in marine geology, marine ecosystems, biogeochemistry, and paleoclimatology. We are working collaboratively with closely-related Building Block projects including EarthCollab and CINERGI, and solicit feedback from RCN projects including Cyberinfrastructure for Paleogeosciences (C4P) and iSamples. GeoLink has developed a modular ontology that describes essential geoscience research concepts; published data from seven collections (to date) on the Web as geospatially-enabled Linked Data using this ontology; matched and mapped data between collections using shared identifiers for investigators, repositories, datasets, funding awards, platforms, research cruises, physical specimens, and gazetteer features; and aggregated the results in a shared knowledgebase that can be queried via a standard SPARQL endpoint. Client applications have been built around the knowledgebase, including a Web/map-based data browser using the Leaflet JavaScript library and a simple query service using the OpenSearch format. Future development will include extending and refining the GeoLink ontology, adding content from additional repositories, developing semi-automated algorithms to enhance metadata, and further work on client applications.

  6. DroidLink: Automated Generation of Deep Links for Android Apps

    OpenAIRE

    Ma, Yun; Liu, Xuanzhe; Du, Ruogu; Hu, Ziniu; Liu, Yi; Yu, Meihua; Huang, Gang

    2016-01-01

    The mobile application (app) has become the main entrance to access the Internet on handheld devices. Unlike the Web where each webpage has a global URL to reach directly, a specific "content page" of an app can be opened only by exploring the app with several operations from the landing page. The interoperability between apps is quite fixed and thus limits the value-added "linked data" between apps. Recently, deep link has been proposed to enable targeting and opening a specific page of an a...

  7. Study IDs 2 Zika Virus Proteins Linked to Microcephaly

    Science.gov (United States)

    ... gov/news/fullstory_160386.html Study IDs 2 Zika Virus Proteins Linked to Microcephaly Discovery might one day ... say they've identified two proteins in the Zika virus linked to the severe birth defect microcephaly. Babies ...

  8. Link Between Money Woes, Domestic Abuse Tough to Untangle

    Science.gov (United States)

    ... news/fullstory_158582.html Link Between Money Woes, Domestic Abuse Tough to Untangle Researchers trying to determine if ... April 29, 2016 (HealthDay News) -- Money problems and domestic violence appear to be linked, but it's not clear ...

  9. Genetics Home Reference: X-linked congenital stationary night blindness

    Science.gov (United States)

    ... stationary night blindness X-linked congenital stationary night blindness Enable Javascript to view the expand/collapse boxes. ... Close All Description X-linked congenital stationary night blindness is a disorder of the retina , which is ...

  10. Capacity and Shaping in Coherent Fiber-Optic Links

    DEFF Research Database (Denmark)

    Estaran Tolosa, Jose Manuel; Zibar, Darko; Tafur Monroy, Idelfonso

    2014-01-01

    Over view of the concepts and latest progress of capacity and constellation shaping incoherent optical links.......Over view of the concepts and latest progress of capacity and constellation shaping incoherent optical links....

  11. Immune System and Its Link to Rheumatic Diseases

    Science.gov (United States)

    ... Disease The Immune System & Its Link to Rheumatic Disease The Immune System and Its Link to Rheumatic Disease Fast ... cells. This leads to illnesses called autoimmune (self-immune) diseases such as rheumatoid arthritis (inflammation of the joints), ...

  12. Genetics Home Reference: X-linked lymphoproliferative disease

    Science.gov (United States)

    ... 2 links) National Institute of Allergy and Infectious Diseases: Primary Immune Deficiency Diseases National Institute of Allergy and Infectious Diseases: Primary Immune Deficiency Diseases Educational Resources (4 links) Children's Hospital ...

  13. Genetics Home Reference: X-linked dystonia-parkinsonism

    Science.gov (United States)

    Skip to main content Your Guide to Understanding Genetic Conditions Enable Javascript for addthis links to activate. ... Conditions Genes Chromosomes & mtDNA Resources Help Me Understand Genetics Home Health Conditions X-linked dystonia-parkinsonism X- ...

  14. Genetics Home Reference: X-linked sideroblastic anemia and ataxia

    Science.gov (United States)

    ... anemia and ataxia X-linked sideroblastic anemia and ataxia Enable Javascript to view the expand/collapse boxes. ... Close All Description X-linked sideroblastic anemia and ataxia is a rare condition characterized by a blood ...

  15. How different are Wikipedia and web link structure?

    OpenAIRE

    Kamps, J.; Koolen, M

    2010-01-01

    In this paper, we investigate the difference between Wikipedia and Web link structure with respect to their value as indicators of the relevance of a page for a given topic of request. Our main findings are: First, Wikipedia link structure is similar to the Web, but more densely linked. Second, Wikipedia’s outlinks behave similar to inlinks and both are good indicators of relevance, whereas on the Web the inlinks are more important. Third, when incorporating link evidence in the retrieval mod...

  16. Quantum Link Models: A Discrete Approach to Gauge Theories

    OpenAIRE

    Chandrasekharan, S; Wiese, U.-J.

    1996-01-01

    We construct lattice gauge theories in which the elements of the link matrices are represented by non-commuting operators acting in a Hilbert space. These quantum link models are related to ordinary lattice gauge theories in the same way as quantum spin models are related to ordinary classical spin systems. Here U(1) and SU(2) quantum link models are constructed explicitly. As Hamiltonian theories quantum link models are nonrelativistic gauge theories with potential applications in condensed ...

  17. LINK OF FISCAL DECENTRALIZATION TO POVERTY REDUCTION: INDONESIAN CONTEXT

    OpenAIRE

    Rr. Sita Dewi Kusumaningrum

    2013-01-01

    Abstract: Link of Fiscal Decentralization to Poverty Reduction: Indonesian Context. It is identified from the literature studies that there are links between fiscal decentralization and poverty reduction. However, the links occurs in different ways among countries and local governments. This is a preliminary study which aims at observing the potential link pattern of fiscal decentralization to poverty reduction in Indonesian provinces before and in the period of fiscal decentralization implem...

  18. In-room Reverberant Multi-link Channels: Preliminary Investigations

    DEFF Research Database (Denmark)

    Steinböck, Gerhard; Pedersen, Troels; Fleury, Bernard Henri;

    We model the delay power spectrum of inroom reverberant multi-link radio channels. The model relies on the empirical observation that the delay power spectrum of each link measured in a closed room, consists of an early peak and a late exponential reverberation tail. The peak vanishes...... spread versus distance for multiple links. These predictions are in good agreement with the estimates obtained from the multi-link measurements....

  19. Linking Gestures: Cross-Cultural Variation during Instructional Analogies

    Science.gov (United States)

    Richland, Lindsey Engle

    2015-01-01

    Deictic linking gestures, hand and arm motions that physically embody links being communicated between two or more objects in the shared communicative environment, are explored in a cross-cultural sample of mathematics instruction. Linking gestures are specifically examined here when they occur in the context of communicative analogies designed to…

  20. Detecting and Reporting Extensional Concept Drift in Statistical Linked Data

    NARCIS (Netherlands)

    A. Meroño-Peñuela; C. Guéret; R. Hoekstra; S. Schlobach

    2013-01-01

    The RDF Data Cube vocabulary is a catalyst for the availability of statistical Linked Data: raw statistical Linked Data are easy to model in, publish to, and retrieve from the Linked Data cloud. In statistical datasets, concepts are central entities represented by variables and their values. The mea

  1. 21 CFR 177.1211 - Cross-linked polyacrylate copolymers.

    Science.gov (United States)

    2010-04-01

    ... polyacrylate copolymers consist of: (1) The grafted copolymer of cross-linked sodium polyacrylate identified as... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Cross-linked polyacrylate copolymers. 177.1211... Basic Components of Single and Repeated Use Food Contact Surfaces § 177.1211 Cross-linked...

  2. How different are Wikipedia and web link structure?

    NARCIS (Netherlands)

    J. Kamps; M. Koolen

    2010-01-01

    In this paper, we investigate the difference between Wikipedia and Web link structure with respect to their value as indicators of the relevance of a page for a given topic of request. Our main findings are: First, Wikipedia link structure is similar to the Web, but more densely linked. Second, Wiki

  3. "LinkedIn" for Accounting and Business Students

    Science.gov (United States)

    Albrecht, W. David

    2011-01-01

    LinkedIn is a social media application that every accounting and business student should join and use. LinkedIn is a database of 90,000,000 business professionals that enables each to connect and interact with their business associates. Five reasons are offered for why accounting students should join LinkedIn followed by 11 hints for use.

  4. Synchronization of Nonlinear Oscillators Over Networks with Dynamic Links

    NARCIS (Netherlands)

    De Persis, Claudio

    2015-01-01

    In this paper we investigate the problem of synchronization of homogeneous nonlinear oscillators coupled by dynamic links. The output of the nonlinear oscillators is the input to the dynamic links, while the output of these dynamics links is the quantity available to the distributed controllers at t

  5. Deciding to Change OpenURL Link Resolvers

    Science.gov (United States)

    Johnson, Megan; Leonard, Andrea; Wiswell, John

    2015-01-01

    This article will be of interest to librarians, particularly those in consortia that are evaluating OpenURL link resolvers. This case study contrasts WebBridge (an Innovative Interface product) and LinkSource (EBSCO's product). This study assisted us in the decision-making process of choosing an OpenURL link resolver that was sustainable to…

  6. THE LINK BETWEEN ACCOUNTING AND FISCAL EVASION

    Directory of Open Access Journals (Sweden)

    Silvia Lăzărescu (Marinescu

    2008-12-01

    Full Text Available In the literature, controversies have arisen concerning the link between accounting and fiscal evasion, which are the object of debates among specialists from different specialized organizations from many countries. Under the term of “creative accounting”, the American and European tax systems have made up an ensemble of accounting mechanisms and also of fiscal manipulation which increased the interest and involvement of the states in the mitigation of such fraud risks and fiscal subterfuges whose percentage in the countries’ GDP varies from 8 to 80%. Starting from the SWOT analysis of tax evasion in the real and underground economy, the specialists of the liberal trades are called to join the fight against fiscal fraud and share their professionalism in creating a real competitive environment characterized by fair play.

  7. Problem Based Learning - Linking Students and Industry

    DEFF Research Database (Denmark)

    Fink, Flemming K.

    2006-01-01

    -oriented project work: students work in teams to solve externally defined problem areas in co-operation with businesses, organisations and public institutions. Project Organised Problem Based Learning (POPBL) has generated a high degree of cooperation with the society and private companies. There are all the time...... is essentially problem solving. The presentation looks into on campus POPBL and the Facilitated Work Based Learning (FBL) for continuing education. It also presents case examples of POPBL work.......WG2_G4 Problem based learning – linking students and industry: a case study from Aalborg, Denmark Flemming K. Flink ELITE Aalborg University In Aalborg University, Denmark, all study programmes are organised around inter-disciplinary project work in groups. Up to 50% of the study work is problem...

  8. Renal cell carcinoma: links and risks

    Science.gov (United States)

    Kabaria, Reena; Klaassen, Zachary; Terris, Martha K

    2016-01-01

    This review provides an overview of the incidence of renal cell carcinoma (RCC) and a summary of the most commonly associated risk factors. A literature review was performed with a focus on recent studies with a high level of evidence (large prospective cohort studies and meta-analyses). The incidence rate of RCC varies globally, with the rate rising rapidly in more developed regions, demonstrating the effects of increased use of diagnostic imaging and prevalence of modifiable risk factors. Based on the current evidence, cigarette smoking, obesity, and hypertension are the most well-established risk factors for sporadic RCC worldwide. Acquired cystic kidney disease is also a significant risk factor, specifically in dialysis patients. There is increasing evidence for an inverse association between RCC risk and moderate alcohol consumption. Certain analgesics and occupational exposure have been linked to an increased risk of RCC, although data are limited. Diets rich in fruits and vegetables may provide a protective effect. PMID:27022296

  9. DataCite and linked data

    Directory of Open Access Journals (Sweden)

    Jan Brase

    2013-01-01

    Full Text Available Science is global, it needs global standards, global workflows and is a cooperation of global players. But science is carried out locally by local scientists that are part of local infrastructures with local funders. DataCite is an international consortium, founded in 2009 of currently 17 institutions from 12 countries worldwide. Its mission is to allow a better re-use and citation of data sets. Over 1 million datasets have been registered with a DOI name as a persistent identifier, so they can be published as independent scientific objects to allow stabile citation of data. Citable data sets can be crosslinked from journal articles, their usage and citations can be measured therefore helping scientists gain credit for making their data available. DataCite offers a central metadata repository with additional linked data service for persistent access to RDF metadata.

  10. Riboflavin for corneal cross-linking.

    Science.gov (United States)

    O'Brart, D P S

    2016-06-01

    Corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A (UVA) radiation is the first therapeutic modality that appears to arrest the progression of keratoconus and other corneal ectasias. Riboflavin is central to the process, acting as a photosensitizer for the production of oxygen singlets and riboflavin triplets. These free radicals drive the CXL process within the proteins of the corneal stroma, altering its biomechanical properties. Riboflavin also absorbs the majority of the UVA radiation, which is potentially cytotoxic and mutagenic, within the anterior stroma, preventing damage to internal ocular structures, such as the corneal endothelium, lens and retina. Clinical studies report cessation of ectatic progression in over 90% of cases and the majority document significant improvements in visual, keratometric and topographic parameters. Clinical follow-up is limited to 5-10 years, but suggests sustained stability and enhancement in corneal shape. Sight-threatening complications are rare. The optimal stromal riboflavin dosage for CXL is as yet undetermined. PMID:27458610

  11. Applying Linked Data Technologies for Online Newspapers

    Directory of Open Access Journals (Sweden)

    Tsvetanka Georgieva-Trifonova

    2015-05-01

    Full Text Available The constantly growing data volume at the companies along with the necessity for finding information for the shortest possible time span involves methods of information search different from the ones conventionally used. The semantic technologies, developed in the late 90s and the beginning of the new century, are viewed as a new generation of databases and as text analyzing technologies. The present paper deals with researching the opportunities and examining the advantages of applying the semantic web technologies and the linked data for online newspapers. Besides, a RDF-based ontology for the purposes of a system for study and evaluation of online editions of regional daily newspapers is proposed. SPARQL endpoint is implemented to access the RDF data.

  12. Hypothyroidism and obesity: An intriguing link.

    Science.gov (United States)

    Sanyal, Debmalya; Raychaudhuri, Moutusi

    2016-01-01

    According to common perception, hypothyroidism is held responsible for obesity. However, linking them causally is controversial. Overt hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism. Novel view indicates that changes in thyroid-stimulating hormone (TSH) could well be secondary to obesity. The increasing prevalence of obesity further confounds definition of normal TSH range in population studies. Thyroid autoantibody status may help in establishing the diagnosis of subclinical hypothyroidism in obesity. High leptin levels may play a role in the hyperthyrotropinemia of obesity and also increase susceptibility to thyroid autoimmunity and subsequent hypothyroidism. There is at most a modest effect of L-T4 treatment in overt hypothyroidism in inducing weight loss; benefit in subclinical hypothyroidism is not established with no data supporting thyroid hormone use in euthyroid obese patients. PMID:27366725

  13. The Cross - linking reaction of HEC

    Institute of Scientific and Technical Information of China (English)

    XIONG; Jian

    2001-01-01

    Cellulose ethers are important components for light industries such as food and papermaking industries. Its modification research is a frontline science to widen their uses and realize their industrialization. The target of modification is to make high production value, low input and meet the needs better in industries.  O-(2-hydroxyethl) cellulose (HEC) is one of the best-known cellulose ether derivatives. It is mainly used as thickeners, dispersants, adhesives, extenders, and films because of its water solubility and gel-forming properties. The present research,by means of cross-linking, we study the influence on HEC about rheological behavior.This will provide a feasible scheme for cellulose ethers modification.……

  14. High Capacity Radio over Fiber Transmission Links

    DEFF Research Database (Denmark)

    Caballero Jambrina, Antonio

    confirmed that this configuration provides high linear end-to-end transmission links and is capable of transparent transport of high spectral efficient modulation formats. Furthermore, this thesis introduces a novel approach for the generation and detection of high speed wireless signals in mm......This thesis expands the state-of-the-art on the detection of high speed wireless signals using optics. Signal detection at speeds over 1 Gbps at carrier Radio Frequency (RF) ranging from 5 GHz to 100 GHz have been achieved by applying novel concepts on optical digital coherent receivers....... This achievement has satisfied the requirements on transmission robustness and high capacity of next generation hybrid optical fibre-wireless networks. One important contribution of this thesis is the novel concept of photonic downconversion with free-running pulsed laser source for phase modulated Radio...

  15. Sharing Epigraphic Information as Linked Data

    Science.gov (United States)

    Álvarez, Fernando-Luis; García-Barriocanal, Elena; Gómez-Pantoja, Joaquín-L.

    The diffusion of epigraphic data has evolved in the last years from printed catalogues to indexed digital databases shared through the Web. Recently, the open EpiDoc specifications have resulted in an XML-based schema for the interchange of ancient texts that uses XSLT to render typographic representations. However, these schemas and representation systems are still not providing a way to encode computational semantics and semantic relations between pieces of epigraphic data. This paper sketches an approach to bring these semantics into an EpiDoc based schema using the Ontology Web Language (OWL) and following the principles and methods of information sharing known as "linked data". The paper describes the general principles of the OWL mapping of the EpiDoc schema and how epigraphic data can be shared in RDF format via dereferenceable URIs that can be used to build advanced search, visualization and analysis systems.

  16. Treating dyslipidemias: is inflammation the missing link?

    Science.gov (United States)

    Papoutsidakis, Nikolaos; Deftereos, Spyridon; Giannopoulos, Georgios; Panagopoulou, Vasiliki; Manolis, Antonis S; Bouras, Georgios

    2014-01-01

    Low-grade chronic inflammation is now being held as an important process in the development of atherosclerosis, with new links between dyslipidemia and inflammation being constantly found. While most studies aim to discover inflammatory pathways leading from dyslipidemia to atherogenesis, there is evidence that inflammation can also act in reverse, altering lipid metabolism in unfavorable ways, possibly creating a vicious cycle of inflammationdyslipidemia- inflammation. This is highly relevant for the search of novel therapeutic targets. In this review, after a brief account of the inflammatory mechanisms leading from dyslipidemia to atherogenesis, we focus on what is currently known about the ways inflammation can impair lipid metabolism and whether anti-inflammatory therapies could have a role in dyslipidemia management.

  17. Hypothyroidism and obesity: An intriguing link

    Science.gov (United States)

    Sanyal, Debmalya; Raychaudhuri, Moutusi

    2016-01-01

    According to common perception, hypothyroidism is held responsible for obesity. However, linking them causally is controversial. Overt hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism. Novel view indicates that changes in thyroid-stimulating hormone (TSH) could well be secondary to obesity. The increasing prevalence of obesity further confounds definition of normal TSH range in population studies. Thyroid autoantibody status may help in establishing the diagnosis of subclinical hypothyroidism in obesity. High leptin levels may play a role in the hyperthyrotropinemia of obesity and also increase susceptibility to thyroid autoimmunity and subsequent hypothyroidism. There is at most a modest effect of L-T4 treatment in overt hypothyroidism in inducing weight loss; benefit in subclinical hypothyroidism is not established with no data supporting thyroid hormone use in euthyroid obese patients. PMID:27366725

  18. Robust bidirectional links for photonic quantum networks.

    Science.gov (United States)

    Xu, Jin-Shi; Yung, Man-Hong; Xu, Xiao-Ye; Tang, Jian-Shun; Li, Chuan-Feng; Guo, Guang-Can

    2016-01-01

    Optical fibers are widely used as one of the main tools for transmitting not only classical but also quantum information. We propose and report an experimental realization of a promising method for creating robust bidirectional quantum communication links through paired optical polarization-maintaining fibers. Many limitations of existing protocols can be avoided with the proposed method. In particular, the path and polarization degrees of freedom are combined to deterministically create a photonic decoherence-free subspace without the need for any ancillary photon. This method is input state-independent, robust against dephasing noise, postselection-free, and applicable bidirectionally. To rigorously quantify the amount of quantum information transferred, the optical fibers are analyzed with the tools developed in quantum communication theory. These results not only suggest a practical means for protecting quantum information sent through optical quantum networks but also potentially provide a new physical platform for enriching the structure of the quantum communication theory.

  19. Improving Schema Matching with Linked Data

    CERN Document Server

    Assaf, Ahmad; Senart, Aline; Follenfant, Corentin; Troncy, Raphaël; Trastour, David

    2012-01-01

    With today's public data sets containing billions of data items, more and more companies are looking to integrate external data with their traditional enterprise data to improve business intelligence analysis. These distributed data sources however exhibit heterogeneous data formats and terminologies and may contain noisy data. In this paper, we present a novel framework that enables business users to semi-automatically perform data integration on potentially noisy tabular data. This framework offers an extension to Google Refine with novel schema matching algorithms leveraging Freebase rich types. First experiments show that using Linked Data to map cell values with instances and column headers with types improves significantly the quality of the matching results and therefore should lead to more informed decisions.

  20. Linking advanced fracture models to structural analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chiesa, Matteo

    2001-07-01

    Shell structures with defects occur in many situations. The defects are usually introduced during the welding process necessary for joining different parts of the structure. Higher utilization of structural materials leads to a need for accurate numerical tools for reliable prediction of structural response. The direct discretization of the cracked shell structure with solid finite elements in order to perform an integrity assessment of the structure in question leads to large size problems, and makes such analysis infeasible in structural application. In this study a link between local material models and structural analysis is outlined. An ''ad hoc'' element formulation is used in order to connect complex material models to the finite element framework used for structural analysis. An improved elasto-plastic line spring finite element formulation, used in order to take cracks into account, is linked to shell elements which are further linked to beam elements. In this way one obtain a global model of the shell structure that also accounts for local flexibilities and fractures due to defects. An important advantage with such an approach is a direct fracture mechanics assessment e.g. via computed J-integral or CTOD. A recent development in this approach is the notion of two-parameter fracture assessment. This means that the crack tip stress tri-axiality (constraint) is employed in determining the corresponding fracture toughness, giving a much more realistic capacity of cracked structures. The present thesis is organized in six research articles and an introductory chapter that reviews important background literature related to this work. Paper I and II address the performance of shell and line spring finite elements as a cost effective tool for performing the numerical calculation needed to perform a fracture assessment. In Paper II a failure assessment, based on the testing of a constraint-corrected fracture mechanics specimen under tension, is

  1. Renal cell carcinoma: links and risks.

    Science.gov (United States)

    Kabaria, Reena; Klaassen, Zachary; Terris, Martha K

    2016-01-01

    This review provides an overview of the incidence of renal cell carcinoma (RCC) and a summary of the most commonly associated risk factors. A literature review was performed with a focus on recent studies with a high level of evidence (large prospective cohort studies and meta-analyses). The incidence rate of RCC varies globally, with the rate rising rapidly in more developed regions, demonstrating the effects of increased use of diagnostic imaging and prevalence of modifiable risk factors. Based on the current evidence, cigarette smoking, obesity, and hypertension are the most well-established risk factors for sporadic RCC worldwide. Acquired cystic kidney disease is also a significant risk factor, specifically in dialysis patients. There is increasing evidence for an inverse association between RCC risk and moderate alcohol consumption. Certain analgesics and occupational exposure have been linked to an increased risk of RCC, although data are limited. Diets rich in fruits and vegetables may provide a protective effect. PMID:27022296

  2. New links between Ecuador and CERN

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    A new protocol recently signed in Quito opens the way to stronger links between the Ecuadorian scientific community and CERN. The operational framework provided by the protocol will enable scientists from Ecuador to take part in CERN’s projects, supported by the Ecuadorian authorities.   Picture taken during the signing ceremony at SENESCYT (Quito, Ecuador) on 12 July 2011. From left to right: Guillermo Solórzano, Minister for Coordination of Knowledge and Human Talent, Rene Ramirez Gallegos, National Secretary for Higher Education, Science and Technology - SENECYT, Felicitas Pauss and Jose Salicio from CERN. Ecuador’s involvement with CERN dates back to 1999 when a first International Co-operation Agreement was signed. However, despite these early beginnings,   only a few scientists from Ecuador, affiliated to non-Ecuadorian institutes, have since been directly involved in CERN’s projects, in particular the CMS experiment a...

  3. The link between copper and Wilson's disease.

    Science.gov (United States)

    Purchase, Rupert

    2013-01-01

    Wilson's disease (hepatolenticular degeneration) is a rare inherited autosomal recessive disorder of copper metabolism leading to copper accumulation in the liver and extrahepatic organs such as the brain and cornea. Patients may present with combinations of hepatic, neurological and psychiatric symptoms. Copper is the therapeutic target for the treatment of Wilson's disease. But how did copper come to be linked with Wilson's disease? The answer encompasses a study of enzootic neonatal ataxia in lambs in the 1930s, the copper-chelating properties of British Anti-Lewisite, and the chemical analysis for copper of the organs of deceased Wilson's disease patients in the mid-to-late 1940s. Wilson's disease is one of a number of copper-related disorders where loss of copper homeostasis as a result of genetic, nutritional or environmental factors affects human health.

  4. A Review of Algebraic Link Analysis Algorithms

    Directory of Open Access Journals (Sweden)

    Mini Singh Ahuja

    2012-08-01

    Full Text Available The World Wide Web is a system of interlinked hypertext documents accessed via the Internet. With a web browser, one can view web pages that may contain text, images, videos, and other multimedia and navigate between them by using hyperlinks. Navigation is the process through which the users can achieve their purposes in using Web site, such as to find the information that they need or to complete the transactions that they want to do. Web mining is the application of data mining techniques to extract knowledge from Web data, where at least one of structure (hyperlink or usage (Web log data is used in the mining process (with or without other types of Web data. In this paper we have briefly discussed the web mining technique with major stress to the link analysis algorithms.

  5. Novel hydroxyapatite biomaterial covalently linked to raloxifene.

    Science.gov (United States)

    Meme, L; Santarelli, A; Marzo, G; Emanuelli, M; Nocini, P F; Bertossi, D; Putignano, A; Dioguardi, M; Lo Muzio, L; Bambini, F

    2014-01-01

    Since raloxifene, a drug used in osteoporosis therapy, inhibits osteoclast, but not osteoblast functions, it has been suggested to improve recovery during implant surgery. The present paper describes an effective method to link raloxifene, through a covalent bond, to a nano-Hydroxyapatite-based biomaterial by interfacing with (3-aminopropyl)-Triethoxysilane as assessed by Infra Red-Fourier Transformed (IR-FT) spectroscopy and Scanning Electron Microscope (SEM). To evaluate the safety of this modified new material, the vitality of osteoblast-like cells cultured with the new biomaterial was then investigated. Raloxifene-conjugated HAbiomaterial has been shown to be a safe material easy to obtain which could be an interesting starting point for the use of a new functional biomaterial suitable in bone regeneration procedures. PMID:25280036

  6. Hypothyroidism and obesity: An intriguing link

    Directory of Open Access Journals (Sweden)

    Debmalya Sanyal

    2016-01-01

    Full Text Available According to common perception, hypothyroidism is held responsible for obesity. However, linking them causally is controversial. Overt hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism. Novel view indicates that changes in thyroid-stimulating hormone (TSH could well be secondary to obesity. The increasing prevalence of obesity further confounds definition of normal TSH range in population studies. Thyroid autoantibody status may help in establishing the diagnosis of subclinical hypothyroidism in obesity. High leptin levels may play a role in the hyperthyrotropinemia of obesity and also increase susceptibility to thyroid autoimmunity and subsequent hypothyroidism. There is at most a modest effect of L-T4 treatment in overt hypothyroidism in inducing weight loss; benefit in subclinical hypothyroidism is not established with no data supporting thyroid hormone use in euthyroid obese patients.

  7. REDEN: Named Entity Linking in Digital Literary Editions Using Linked Data Sets

    Directory of Open Access Journals (Sweden)

    Carmen Brando

    2016-07-01

    Full Text Available This paper proposes a graph-based Named Entity Linking (NEL algorithm named REDEN for the disambiguation of authors’ names in French literary criticism texts and scientific essays from the 19th and early 20th centuries. The algorithm is described and evaluated according to the two phases of NEL as reported in current state of the art, namely, candidate retrieval and candidate selection. REDEN leverages knowledge from different Linked Data sources in order to select candidates for each author mention, subsequently crawls data from other Linked Data sets using equivalence links (e.g., owl:sameAs, and, finally, fuses graphs of homologous individuals into a non-redundant graph well-suited for graph centrality calculation; the resulting graph is used for choosing the best referent. The REDEN algorithm is distributed in open-source and follows current standards in digital editions (TEI and semantic Web (RDF. Its integration into an editorial workflow of digital editions in Digital humanities and cultural heritage projects is entirely plausible. Experiments are conducted along with the corresponding error analysis in order to test our approach and to help us to study the weaknesses and strengths of our algorithm, thereby to further improvements of REDEN.

  8. Linking the Fits, Fitting the Links: Connecting Different Types of PO Fit to Attitudinal Outcomes

    Science.gov (United States)

    Leung, Aegean; Chaturvedi, Sankalp

    2011-01-01

    In this paper we explore the linkages among various types of person-organization (PO) fit and their effects on employee attitudinal outcomes. We propose and test a conceptual model which links various types of fits--objective fit, perceived fit and subjective fit--in a hierarchical order of cognitive information processing and relate them to…

  9. X-linked cardiomyopathy is heterogeneous

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, M.J.; Sillence, D.O.; Mulley, J.C. [and others

    1994-09-01

    Two major loci of X-linked cardiomyopathy have been mapped by linkage analysis. The gene for X-linked dilated cardiomyopathy (XLCM) is mapped to the dystrophin locus at Xp21, while Barth syndrome has been localised to distal Xq28. XLCM usually presents in juvenile males with no skeletal disease but decreased dystrophin in cardiac muscle. Barth syndrome most often presents in infants and is characterized by skeletal myopathy, short stature and neutropenia in association with cardiomyopathy of variable severity. Prior to carrier or prenatal diagnosis in a family, delineation of the cardiomyopathy locus involved is essential. We report the linkage mapping of a large kindred in which several male infants have died with hypertrophic cardiomyopathy. There is a family history of unexplained death of infant males less than 6 months old over 4 generations. Features of Barth syndrome such as short stature, skeletal myopathy and neutropenia have not been observed. Genotyping at 10 marker loci in Xq28 has revealed significant pairwise lod scores with the cardiomyopathy phenotype at DXS52 (Z=2.21 at {theta}=0.0), at markers p26 and p39 near DXS15 (Z=2.30 at {theta}=0.0) and at F8C (Z=2.24 at {theta}=0.0). A recombinant detected with DXS296 defines the proximal limit to the localization. No recombinants were detected at any of the loci distal to DXS296. The most distal marker in Xq28, DXS1108, is within 500 kb of the telomere. As the gene in this family is localized to Xq28, it is possible that this disorder is an allelic variant at the Barth syndrome locus.

  10. Smart POI: Open and linked spatial data

    Science.gov (United States)

    Cerba, Otakar; Berzins, Raitis; Charvat, Karel; Mildorf, Tomas

    2016-04-01

    The Smart Point of Interest (SPOI) represents an unique seamless spatial data set based on standards recommended for Linked and open data, which are supported by scientist and researchers as well as by several government authorities and European Union. This data set developed in cooperation of partners of SDI4Apps project contains almost 24 millions points of interest focused mainly on tourism, natural features, transport or citizen services. The SPOI data covers almost all countries and territories over the world. It is created as a harmonized combination of global data resources (selected points from OpenStreetMap, Natural Earth and GeoNames.org) and several local data sets (for example data published by the Citadel on the Move project, data from Posumavi region in the Czech Republic or experimental ontologies developed in the University of West Bohemia including ski regions in Europe or historical sights in Rome). The added value of the SDI4Apps approach in comparison to other similar solutions consists in implementation of linked data approach (several objects are connected to DBpedia or GeoNames.org), using of universal RDF format, using of standardized and respected properties or vocabularies (for example FOAF or GeoSPARQL) and development of the completely harmonized data set with uniform data model and common classification (not only a copy of original resources). The SPOI data is published as SPARQL endpoint as well as in the map client. The SPOI dataset is a specific set of POIs which could be "a data fuel" for applications and services related to tourism, local business, statistics or landscape monitoring. It can be used also as a background data layer for thematic maps.

  11. Links between energy and food markets. A preliminary assessment

    Energy Technology Data Exchange (ETDEWEB)

    Silvis, H.J.; Woltjer, G.B.

    2010-04-15

    This report addresses the links between energy and food markets, and the long-term trends and large short-term fluctuations they have undergone. The ways in which these markets are related and which feedback mechanisms must be taken into account in scenario analyses were investigated. On the basis of international studies and prognoses, three links connecting energy and food markets were identified. The first link is formed by the common drivers on the demand side, namely demographic and economic developments, the second link is related to the energy costs of agricultural and food production and distribution, and the third link comprises the role of agriculture as a producer of energy.

  12. Multi-Functional Fibre-Optic Microwave Links

    DEFF Research Database (Denmark)

    Gliese, Ulrik Bo

    1998-01-01

    The multi-functionality of microwave links based on remote heterodyne detection of signals from a dual-frequency laser transmitter is discussed and experimentally demonstrated in this paper. Typically, direct detection in conjunction with optical intensity modulation is used to implement fibre......-optic microwave links. The resulting links are inherently transparent and mainly used for signal transmission. As opposed to direct detection links, remote heterodyne detection links can directly perform functionalities such as modulation, frequency conversion, and transparent signal recovery in addition...

  13. Critical Links and Nonlocal Rerouting in Complex Supply Networks

    Science.gov (United States)

    Witthaut, Dirk; Rohden, Martin; Zhang, Xiaozhu; Hallerberg, Sarah; Timme, Marc

    2016-04-01

    Link failures repeatedly induce large-scale outages in power grids and other supply networks. Yet, it is still not well understood which links are particularly prone to inducing such outages. Here we analyze how the nature and location of each link impact the network's capability to maintain a stable supply. We propose two criteria to identify critical links on the basis of the topology and the load distribution of the network prior to link failure. They are determined via a link's redundant capacity and a renormalized linear response theory we derive. These criteria outperform the critical link prediction based on local measures such as loads. The results not only further our understanding of the physics of supply networks in general. As both criteria are available before any outage from the state of normal operation, they may also help real-time monitoring of grid operation, employing countermeasures and support network planning and design.

  14. Critical links and nonlocal rerouting in complex supply networks

    CERN Document Server

    Witthaut, Dirk; Zhang, Xiaozhu; Hallerberg, Sarah; Timme, Marc

    2015-01-01

    Link failures repeatedly induce large-scale outages in power grids and other supply networks. Yet, it is still not well understood, which links are particularly prone to inducing such outages. Here we analyze how the nature and location of each link impact the network's capability to maintain stable supply. We propose two criteria to identify critical links on the basis of the topology and the load distribution of the network prior to link failure. They are determined via a link's redundant capacity and a renormalized linear response theory we derive. These criteria outperform critical link prediction based on local measures such as loads. The results not only further our understanding of the physics of supply networks in general. As both criteria are available before any outage from the state of normal operation, they may also help real-time monitoring of grid operation, employing counter-measures and support network planning and design.

  15. Critical Links and Nonlocal Rerouting in Complex Supply Networks.

    Science.gov (United States)

    Witthaut, Dirk; Rohden, Martin; Zhang, Xiaozhu; Hallerberg, Sarah; Timme, Marc

    2016-04-01

    Link failures repeatedly induce large-scale outages in power grids and other supply networks. Yet, it is still not well understood which links are particularly prone to inducing such outages. Here we analyze how the nature and location of each link impact the network's capability to maintain a stable supply. We propose two criteria to identify critical links on the basis of the topology and the load distribution of the network prior to link failure. They are determined via a link's redundant capacity and a renormalized linear response theory we derive. These criteria outperform the critical link prediction based on local measures such as loads. The results not only further our understanding of the physics of supply networks in general. As both criteria are available before any outage from the state of normal operation, they may also help real-time monitoring of grid operation, employing countermeasures and support network planning and design. PMID:27082006

  16. Conditioned reinforcement dynamics in three-link chained schedules.

    Science.gov (United States)

    Williams, B A

    1997-01-01

    In two experiments rats were trained on three-link concurrent-chains schedules of reinforcement. In Experiment 1, additional entries to one terminal link were added during one of the middle links to a baseline schedule that was otherwise equal for the two chains, and, depending on the condition, these additional terminal-link presentations ended either in food or in no food. When food occurred, preference was always in favor of the chain with the additional terminal-link presentations (which also entailed a higher rate of reinforcement). When no food occurred at the end of the additional terminal links, the outcome depended on the nature of the stimuli associated with these additional terminal links. When stimuli different from the reinforced baseline terminal links were used for the no-food terminal links, preference was against the choice alternative that led to the extra periods of extinction. When the same stimulus was used for the two kinds of terminal links, preference was near indifference, that is, significantly greater than when different stimuli were used. In Experiment 2, rats learned repeated reversals of a simultaneous discrimination under a three-link concurrent-chains schedule, in which the food or no-food choice outcomes were delayed until the end of the chain. Different conditions were defined by the point in the chain at which differential stimuli occurred. When the middle and terminal links provided no differential stimuli, discrimination was acquired more slowly than when differential stimuli occurred in both links. When differential stimuli occurred in the middle but not the terminal links, acquisition rates were intermediate. Both experiments together show that the effects of stimuli in a chain schedule are due partly to the time to food correlated with the stimuli and partly to the time to the next conditioned reinforcer in the sequence.

  17. The linking number in systems with Periodic Boundary Conditions

    Science.gov (United States)

    Panagiotou, E.

    2015-11-01

    Periodic Boundary Conditions (PBC) are often used for the simulation of complex physical systems. Using the Gauss linking number, we define the periodic linking number as a measure of entanglement for two oriented curves in a system employing PBC. In the case of closed chains in PBC, the periodic linking number is an integer topological invariant that depends on a finite number of components in the periodic system. For open chains, the periodic linking number is an infinite series that accounts for all the topological interactions in the periodic system. In this paper we give a rigorous proof that the periodic linking number is defined for the infinite system, i.e., that it converges for one, two, and three PBC models. It gives a real number that varies continuously with the configuration and gives a global measure of the geometric complexity of the system of chains. Similarly, for a single oriented chain, we define the periodic self-linking number and prove that it also is defined for open chains. In addition, we define the cell periodic linking and self-linking numbers giving localizations of the periodic linking numbers. These can be used to give good estimates of the periodic linking numbers in infinite systems. We also define the local periodic linking number associated to chains in the immediate cell neighborhood of a chain in order to study local linking measures in contrast to the global linking measured by the periodic linking numbers. Finally, we study and compare these measures when applied to a PBC model of polyethylene melts.

  18. Browsing and Visualization of Linked Environmental Data

    Science.gov (United States)

    Nikolaou, Charalampos; Kyzirakos, Kostis; Bereta, Konstantina; Dogani, Kallirroi; Koubarakis, Manolis

    2014-05-01

    Linked environmental data has started to appear on the Web as environmental researchers make use of technologies such as ontologies, RDF, and SPARQL. Many of these datasets have an important geospatial and temporal dimension. The same is true also for the Web of data that is being rapidly populated not only with geospatial information, but also with temporal information. As the real-world entities represented in linked geospatial datasets evolve over time, the datasets themselves get updated and both the spatial and the temporal dimension of data become significant for users. For example, in the Earth Observation and Environment domains, data is constantly produced by satellite sensors and is associated with metadata containing, among others, temporal attributes, such as the time that an image was acquired. In addition, the acquisitions are considered to be valid for specific periods of time, for example until they get updated by new acquisitions. Satellite acquisitions might be utilized in applications such as the CORINE Land Cover programme operated by the European Environment Agency that makes available as a cartographic product the land cover of European areas. Periodically CORINE publishes the changes in the land cover of these areas in the form of changesets. Tools for exploiting the abundance of geospatial information have also started to emerge. However, these tools are designed for browsing a single data source, while in addition they cannot represent the temporal dimension. This is for two reasons: a) the lack of an implementation of a data model and a query language with temporal features covering the various semantics associated with the representation of time (e.g., valid and user-defined), and b) the lack of a standard temporal extension of RDF that would allow practitioners to utilize when publishing RDF data. Recently, we presented the temporal features of the data model stRDF, the query language stSPARQL, and their implementation in the geospatial

  19. Renal cell carcinoma: links and risks

    Directory of Open Access Journals (Sweden)

    Kabaria R

    2016-03-01

    Full Text Available Reena Kabaria, Zachary Klaassen, Martha K Terris Department of Surgery, Section of Urology, Augusta University, Augusta, GA, USA Abstract: This review provides an overview of the incidence of renal cell carcinoma (RCC and a summary of the most commonly associated risk factors. A literature review was performed with a focus on recent studies with a high level of evidence (large prospective cohort studies and meta-analyses. The incidence rate of RCC varies globally, with the rate rising rapidly in more developed regions, demonstrating the effects of increased use of diagnostic imaging and prevalence of modifiable risk factors. Based on the current evidence, cigarette smoking, obesity, and hypertension are the most well-established risk factors for sporadic RCC worldwide. Acquired cystic kidney disease is also a significant risk factor, specifically in dialysis patients. There is increasing evidence for an inverse association between RCC risk and moderate alcohol consumption. Certain analgesics and occupational exposure have been linked to an increased risk of RCC, although data are limited. Diets rich in fruits and vegetables may provide a protective effect. Keywords: renal cell carcinoma, risk factors, incidence, smoking, obesity, hypertension

  20. Stronger links between CERN and South Africa

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    iThemba LABS in South Africa is a research facility that, about twenty years ago, started to treat oncological patients with particle beams. Its collaboration with CERN has steadily grown over the years. After becoming a member of the ALICE and ATLAS Collaborations, today iThemba LABS is planning to buy a new medical-use cyclotron proton facility, and is seeking to strengthen its links with CERN and Europe also in this field by collaborating with ENLIGHT. The cyclotron will be dedicated to proton therapy – the only one of its kind in the southern hemisphere.   iThemba LABS (Laboratory for Accelerator Based Sciences) was established near Cape Town, South Africa almost 50 years ago as the continent's base for the Southern Universities Nuclear Institute that is now used mainly for material science research. In the 1980s, iThemba built a 200MeV cyclotron and, following its construction, in the early 1990s branched into a new scientific field: radiation and nuclear medicine. ...

  1. MAPCERN links to Google Street View

    CERN Multimedia

    Matilda Heron

    2015-01-01

    CERN’s online maps, MAPCERN, now have the added bonus of Google Street View, thanks to the new release of images of many CERN sites captured by Google.   New Street View images of CERN sites have been added to MAPCERN, see bottom-right-hand image in the screenshot above.   Google Street View, an integrated service of Google Maps introduced in 2007, links 360-degree panoramic photos into a virtual tour. CERN and Google began collaborating on this Street View project in 2010 and now these Street View images have been embedded into MAPCERN, accessible by clicking the “Street View” tab in MAPCERN’s bottom-right-hand window. If you need to locate a building at CERN, or plan an operation on some equipment, you can save time by using the Street View images to check out the area in advance. The CERN Meyrin site has been fully mapped, as well as the surfaces of the eight LHC points, BA2 and BA3. New Street View images of CERN, including the Pr...

  2. optical links for the atlas pixel detector

    CERN Document Server

    Stucci, Stefania Antonia; The ATLAS collaboration

    2015-01-01

    Optical links are necessary to satisfy the high speed readout over long distances for advanced silicon detector systems. We report on the optical readout used in the newly installed central pixel layer (IBL) in the ATLAS experiment. The off detector readout employs commercial optical to analog converters, which were extensively tested for this application. Performance measurements during installation and commissioning will be shown. With the increasing instantaneous luminosity in the next years, the next layers outwards of IBL of the ATLAS Pixel detector (Layer 1 and Layer 2) will reach their bandwidth limits. A plan to increase the bandwidth by upgrading the off detector readout chain is put in place. The plan also involves new optical readout components, in particular the optical receivers, for which commercial units cannot be used and a new design has been made. The latter allows for a wider operational range in term of data frequency and light input power to match the on-detector sending units on the pres...

  3. Optical links for the ATLAS Pixel detector

    CERN Document Server

    Stucci, Stefania Antonia; The ATLAS collaboration

    2015-01-01

    Optical links are necessary to satisfy the high speed readout over long distances for advanced silicon detector systems. We report on the optical readout used in the newly installed central pixel layer (IBL) in the ATLAS experiment. The off detector readout employs commercial optical to analog converters, which were extensively tested for this application. Performance measurements during installation and commissioning will be shown. With the increasing instantaneous luminosity in the next years, the next layers outwards of IBL of the ATLAS Pixel detector (Layer 1 and Layer 2) will reach their bandwidth limits. A plan to increase the bandwidth by upgrading the off detector readout chain is put in place. The plan also involves new optical readout components, in particular the optical receivers, for which commercial units cannot be used and a new design has been made. The latter allows for a wider operational range in term of data frequency and light input power to match the on-detector sending units on the pres...

  4. Nonlinear elasticity of cross-linked networks

    Science.gov (United States)

    John, Karin; Caillerie, Denis; Peyla, Philippe; Raoult, Annie; Misbah, Chaouqi

    2013-04-01

    Cross-linked semiflexible polymer networks are omnipresent in living cells. Typical examples are actin networks in the cytoplasm of eukaryotic cells, which play an essential role in cell motility, and the spectrin network, a key element in maintaining the integrity of erythrocytes in the blood circulatory system. We introduce a simple mechanical network model at the length scale of the typical mesh size and derive a continuous constitutive law relating the stress to deformation. The continuous constitutive law is found to be generically nonlinear even if the microscopic law at the scale of the mesh size is linear. The nonlinear bulk mechanical properties are in good agreement with the experimental data for semiflexible polymer networks, i.e., the network stiffens and exhibits a negative normal stress in response to a volume-conserving shear deformation, whereby the normal stress is of the same order as the shear stress. Furthermore, it shows a strain localization behavior in response to an uniaxial compression. Within the same model we find a hierarchy of constitutive laws depending on the degree of nonlinearities retained in the final equation. The presented theory provides a basis for the continuum description of polymer networks such as actin or spectrin in complex geometries and it can be easily coupled to growth problems, as they occur, for example, in modeling actin-driven motility.

  5. Linking basic variables to binary data world

    International Nuclear Information System (INIS)

    Personal microcomputers have gained unprecedented popularity thanks to the BASIC language handiness. Its use in small data acquisition system encounters, however, two main drawbacks. The first concerns the slow response of the BASIC interpreter implemented in these small systems; the second is due to a very poor communication between the BASIC world and the machine-coded world. All BASIC symbols for variables, arrays or strings which are so easy to handle, remain unknown to the acquisition machine-language program. Moreover, complex mathematical expressions needed for, say, some non linear correction or control, could be managed in BASIC but would be painful to program even in Assembler's language. This paper shows that, using the dynamical variable pointer, one can implement a natural link between the two worlds, allowing powerful features to BASIC's interpreter in data acquisition systems. In particular, A) A machine coded program written for data logging can get access to BASIC variables and directly transfers data to them without suffering interpreters slow speed. BASIC programs just use them as any other variables. B) A manifold user's call, giving control to different machine coded programs without having to change the user's address as usual. (orig.)

  6. Linking energetics and overwintering in temperate insects.

    Science.gov (United States)

    Sinclair, Brent J

    2015-12-01

    Overwintering insects cannot feed, and energy they take into winter must therefore fuel energy demands during autumn, overwintering, warm periods prior to resumption of development in spring, and subsequent activity. Insects primarily consume lipids during winter, but may also use carbohydrate and proteins as fuel. Because they are ectotherms, the metabolic rate of insects is temperature-dependent, and the curvilinear nature of the metabolic rate-temperature relationship means that warm temperatures are disproportionately important to overwinter energy use. This energy use may be reduced physiologically, by reducing the slope or elevation of the metabolic rate-temperature relationship, or because of threshold changes, such as metabolic suppression upon freezing. Insects may also choose microhabitats or life history stages that reduce the impact of overwinter energy drain. There is considerable capacity for overwinter energy drain to affect insect survival and performance both directly (via starvation) or indirectly (for example, through a trade-off with cryoprotection), but this has not been well-explored. Likewise, the impact of overwinter energy drain on growing-season performance is not well understood. I conclude that overwinter energetics provides a useful lens through which to link physiology and ecology and winter and summer in studies of insect responses to their environment.

  7. Chemokine Systems Link Obesity to Insulin Resistance

    Directory of Open Access Journals (Sweden)

    Tsuguhito Ota

    2013-06-01

    Full Text Available Obesity is a state of chronic low-grade systemic inflammation. This chronic inflammation is deeply involved in insulin resistance, which is the underlying condition of type 2 diabetes and metabolic syndrome. A significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs. Chemokines are small proteins that direct the trafficking of immune cells to sites of inflammation. In addition, chemokines activate the production and secretion of inflammatory cytokines through specific G protein-coupled receptors. ATM accumulation through C-C motif chemokine receptor 2 and its ligand monocyte chemoattractant protein-1 is considered pivotal in the development of insulin resistance. However, chemokine systems appear to exhibit a high degree of functional redundancy. Currently, more than 50 chemokines and 18 chemokine receptors exhibiting various physiological and pathological properties have been discovered. Therefore, additional, unidentified chemokine/chemokine receptor pathways that may play significant roles in ATM recruitment and insulin sensitivity remain to be fully identified. This review focuses on some of the latest findings on chemokine systems linking obesity to inflammation and subsequent development of insulin resistance.

  8. Yankee links computing needs, increases productivity

    International Nuclear Information System (INIS)

    Yankee Atomic Electric Company provides design and consultation services to electric utility companies that operate nuclear power plants. This means bringing together the skills and talents of more than 500 people in many disciplines, including computer-aided design, human resources, financial services, and nuclear engineering. The company was facing a problem familiar to many companies in the nuclear industry.Key corporate data and applications resided on UNIX or other types of computer systems, but most users at Yankee had personal computers on their desks. How could Yankee enable the PC users to share the data, applications, and resources of the larger computing environment such as UNIX, while ensuring they could still use their favorite PC applications? The solution was PC-NFS from Sunsoft, of Chelmsford, Mass., which links PCs to UNIX and other systems. The Yankee computing story is an example of computer downsizing-the trend of moving away from mainframe computers in favor of lower-cost, more flexible client/server computing. Today, Yankee Atomic has more than 350 PCs on desktops throughout the company, using PC-NFS, which enables them t;o use the data, applications, disks, and printers of the FUNIX server systems. This new client/server environment has reduced Yankee's computing costs while increasing its computing power and its ability to respond to customers

  9. Link between vitamin D and airway remodeling

    Directory of Open Access Journals (Sweden)

    Berraies A

    2014-04-01

    Full Text Available Anissa Berraies, Kamel Hamzaoui, Agnes HamzaouiPediatric Respiratory Diseases Department, Abderrahmen Mami Hospital, Ariana, and Research Unit 12SP15 Tunis El Manar University, Tunis, TunisiaAbstract: In the last decade, many epidemiologic studies have investigated the link between vitamin D deficiency and asthma. Most studies have shown that vitamin D deficiency increases the risk of asthma and allergies. Low levels of vitamin D have been associated with asthma severity and loss of control, together with recurrent exacerbations. Remodeling is an early event in asthma described as a consequence of production of mediators and growth factors by inflammatory and resident bronchial cells. Consequently, lung function is altered, with a decrease in forced expiratory volume in one second and exacerbated airway hyperresponsiveness. Subepithelial fibrosis and airway smooth muscle cell hypertrophy are typical features of structural changes in the airways. In animal models, vitamin D deficiency enhances inflammation and bronchial anomalies. In severe asthma of childhood, major remodeling is observed in patients with low vitamin D levels. Conversely, the antifibrotic and antiproliferative effects of vitamin D in smooth muscle cells have been described in several experiments. In this review, we briefly summarize the current knowledge regarding the relationship between vitamin D and asthma, and focus on its effect on airway remodeling and its potential therapeutic impact for asthma.Keywords: vitamin D, asthma, airway remodeling, airway smooth muscle, supplementation

  10. Missing Links in Antibody Assembly Control

    Directory of Open Access Journals (Sweden)

    Tiziana Anelli

    2013-01-01

    Full Text Available Fidelity of the humoral immune response requires that quiescent B lymphocytes display membrane bound immunoglobulin M (IgM on B lymphocytes surface as part of the B cell receptor, whose function is to recognize an antigen. At the same time B lymphocytes should not secrete IgM until recognition of the antigen has occurred. The heavy chains of the secretory IgM have a C-terminal tail with a cysteine instead of a membrane anchor, which serves to covalently link the IgM subunits by disulfide bonds to form “pentamers” or “hexamers.” By virtue of the same cysteine, unassembled secretory IgM subunits are recognized and retained (via mixed disulfide bonds by members of the protein disulfide isomerase family, in particular ERp44. This so-called “thiol-mediated retention” bars assembly intermediates from prematurely leaving the cell and thereby exerts quality control on the humoral immune response. In this essay we discuss recent findings on how ERp44 governs such assembly control in a pH-dependent manner, shuttling between the cisGolgi and endoplasmic reticulum, and finally on how pERp1/MZB1, possibly as a co-chaperone of GRP94, may help to overrule the thiol-mediated retention in the activated B cell to give way to antibody secretion.

  11. Optical Link ASICs for the LHC Upgrade

    CERN Document Server

    Gan, K K; Kass, R D; Moore, J R; Smith, D S

    2009-01-01

    We have designed three ASICs for possible applications in the optical links of a new layer of pixel detector in the ATLAS experiment for the first phase of the LHC luminosity upgrade. The ASICs include a high-speed driver for the VCSEL, a receiver/decoder to decode the signal received at the PIN diode to extract the data and clock, and a clock multiplier to produce a higher frequency clock to serialize the data for transmission. These ASICs were designed using a 130 nm CMOS process to enhance the radiation-hardness. We have characterized the fabricated ASICs and the submission has been mostly successful. We irradiated the ASICs with 24 GeV/c protons at CERN to a dosage of 70 Mrad. We observed no significant degradation except the driver circuit in the VCSEL driver fabricated using the thick oxide process in order to provide sufficient voltage to drive a VCSEL. The degradation is due to a large threshold shifts in the PMOS transistors used.

  12. AGN Absorption Linked to Host Galaxies

    CERN Document Server

    Juneau, Stéphanie

    2013-01-01

    Multiwavelength identification of AGN is crucial not only to obtain a more complete census, but also to learn about the physical state of the nuclear activity (obscuration, efficiency, etc.). A panchromatic strategy plays an especially important role when the host galaxies are star-forming. Selecting far-Infrared galaxies at 0.3link between X-ray absorption and either the gas fraction or the gas geometry in the hosts. These findings have implications for our current understanding of both the AGN unification model and the nature of the black hole-galaxy connection. These proceedi...

  13. Linking energetics and overwintering in temperate insects.

    Science.gov (United States)

    Sinclair, Brent J

    2015-12-01

    Overwintering insects cannot feed, and energy they take into winter must therefore fuel energy demands during autumn, overwintering, warm periods prior to resumption of development in spring, and subsequent activity. Insects primarily consume lipids during winter, but may also use carbohydrate and proteins as fuel. Because they are ectotherms, the metabolic rate of insects is temperature-dependent, and the curvilinear nature of the metabolic rate-temperature relationship means that warm temperatures are disproportionately important to overwinter energy use. This energy use may be reduced physiologically, by reducing the slope or elevation of the metabolic rate-temperature relationship, or because of threshold changes, such as metabolic suppression upon freezing. Insects may also choose microhabitats or life history stages that reduce the impact of overwinter energy drain. There is considerable capacity for overwinter energy drain to affect insect survival and performance both directly (via starvation) or indirectly (for example, through a trade-off with cryoprotection), but this has not been well-explored. Likewise, the impact of overwinter energy drain on growing-season performance is not well understood. I conclude that overwinter energetics provides a useful lens through which to link physiology and ecology and winter and summer in studies of insect responses to their environment. PMID:26615721

  14. On the dynamics of swimming linked bodies

    CERN Document Server

    Kajtar, J B

    2009-01-01

    In this paper we study the motion of three linked ellipses moving through a viscous fluid in two dimensions. The angles between the ellipses change with time in a specified manner (the gait) and the resulting time varying configuration is similar to the appearance of a swimming leech. We simulate the motion using the particle method Smoothed Particle Hydrodynamics (SPH) which we test by convergence studies and by comparison with the inviscid results of Kanso et al. (2005) and the viscous results of Eldredge (2006, 2007, 2008). We determine how the average speed and power output depends on the amplitude and oscillation frequency of the gait. We find that the results fit simple scaling rules which can related to the analytical results of G. I. Taylor for the swimming of long narrow animals (1952). We apply our results to estimate the speed of a swimming leech with reasonable accuracy, and we determine the minimum power required to propel the bodies at a specified average speed.

  15. Strengthening the link between science and society

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    On Friday 8 July, the lifts in the Main Building filled with directors-general, assistant directors-general, chiefs of staff, and secretaries-general from a veritable alphabet soup of international organisations. They were heading to a round-table discussion about science and society, chaired by CERN Director-General, Rolf Heuer. “We need to get away from talking like the dense books we read, and start speaking in ‘normal’ language,” said one of the delegates during the round table. The 19 high-ranking delegates from UNESCO, DOE, WHO, WMO, and OECD – to name but a few – sat over coffee and a working lunch, sharing ideas and opinions in a deliberately informal setting. Are the benefits of science being appropriately communicated to decision makers? How will basic research cope during these tough economic times? How can the applications of scientific research be more firmly linked to basic scientific research? Delegates jumped from topic to topic: fr...

  16. A new nonsyndromic X-linked sensorineural hearing impairment linked to Xp21.2

    Energy Technology Data Exchange (ETDEWEB)

    Lalwani, A.K.; Brister, J.R.; Fex, J.; Grundfast, K.M.; Pikus, A.T.; Ploplis, B.; San Agustin, T.; Skarka, H.; Wilcox, E.R. [National Institutes of Health, Bethesda, MD (United States)

    1994-10-01

    X-linked deafness is a rare cause of hereditary hearing impairment. We have identified a family with X-linked dominant sensorineural hearing impairment, characterized by incomplete penetrance and variable expressivity in carrier females, that is linked to the Xp21.2, which contains the Duchenne muscular dystrophy (DMD) locus. The auditory impairment in affected males was congenital, bilateral, profound, sensorineural, affecting all frequencies, and without evidence of radiographic abnormality of the temporal bone. Adult carrier females manifested bilateral, mild-to-moderate high-frequency sensorineural hearing impairment of delayed onset during adulthood. Eighteen commercially available polymorphic markers from the X chromosome, generating a 10-15-cM map, were initially used for identification of a candidate region. DXS997, located within the DMD gene, generated a two-point LOD score of 2.91 at {theta} = 0, with every carrier mother heterozygous at this locus. Recombination events at DXS992 (located within the DMD locus, 3{prime} to exon 50 of the dystrophin gene) and at DXS1068 (5{prime} to the brain promoter of the dystrophin gene) were observed. No recombination events were noted with the following markers within the DMD locus: 5{prime}DYS II, intron 44, DXS997, and intron 50. There was no clinical evidence of Duchenne or Becker muscular dystrophy in any family member. It is likely that this family represents a new locus on the X chromosome, which when mutated results in nonsyndromic sensorineural hearing loss and is distinct from the heterogeneous group of X-linked hearing losses that have been previously described. 57 refs., 6 figs., 1 tab.

  17. Synthesis of dye linked conducting block copolymers, dye linked conducting homopolymers and preliminary application to photovoltaics

    DEFF Research Database (Denmark)

    Krebs, Frederik C; Hagemann, O.; Jørgensen, M.

    2004-01-01

    A synthetic approach to the synthesis of a large super molecule composed of two chemically different conducting polymer blocks with, respectively, high and low lying electronic energy levels linked through a porphyrin dye molecule is presented. The synthetic strategies to these molecular architec...... architectures are discussed. Finally the molecular systems are applied to make photovoltaic devices and the rather low efficiency is discussed in terms of the synthetic approach. (C) 2004 Elsevier B.V. All rights reserved....

  18. Simulation of Controller Pilot Data Link Communications over VHF Digital Link Mode 3

    Science.gov (United States)

    Bretmersky, Steven C.; Murawski, Robert; Nguyen, Thanh C.; Raghavan, Rajesh S.

    2004-01-01

    The Federal Aviation Administration (FAA) has established an operational plan for the future Air Traffic Management (ATM) system, in which the Controller Pilot Data Link Communications (CPDLC) is envisioned to evolve into digital messaging that will take on an ever increasing role in controller to pilot communications, significantly changing the way the National Airspace System (NAS) is operating. According to FAA, CPDLC represents the first phase of the transition from the current analog voice system to an International Civil Aviation Organization (ICAO) compliant system in which digital communication becomes the alternate and perhaps primary method of routine communication. The CPDLC application is an Air Traffic Service (ATS) application in which pilots and controllers exchange messages via an addressed data link. CPDLC includes a set of clearance, information, and request message elements that correspond to existing phraseology employed by current Air Traffic Control (ATC) procedures. These message elements encompass altitude assignments, crossing constraints, lateral deviations, route changes and clearances, speed assignments, radio frequency assignments, and various requests for information. The pilot is provided with the capability to respond to messages, to request clearances and information, to report information, and to declare/rescind an emergency. A 'free text' capability is also provided to exchange information not conforming to defined formats. This paper presents simulated results of the aeronautical telecommunication application Controller Pilot Data Link Communications over VHF Digital Link Mode 3 (VDL Mode 3). The objective of this simulation study was to determine the impact of CPDLC traffic loads, in terms of timely message delivery and capacity of the VDL Mode 3 subnetwork. The traffic model is based on and is used for generating air/ground messages with different priorities. Communication is modeled for the en route domain of the Cleveland

  19. Cross-link guided molecular modeling with ROSETTA.

    Directory of Open Access Journals (Sweden)

    Abdullah Kahraman

    Full Text Available Chemical cross-links identified by mass spectrometry generate distance restraints that reveal low-resolution structural information on proteins and protein complexes. The technology to reliably generate such data has become mature and robust enough to shift the focus to the question of how these distance restraints can be best integrated into molecular modeling calculations. Here, we introduce three workflows for incorporating distance restraints generated by chemical cross-linking and mass spectrometry into ROSETTA protocols for comparative and de novo modeling and protein-protein docking. We demonstrate that the cross-link validation and visualization software Xwalk facilitates successful cross-link data integration. Besides the protocols we introduce XLdb, a database of chemical cross-links from 14 different publications with 506 intra-protein and 62 inter-protein cross-links, where each cross-link can be mapped on an experimental structure from the Protein Data Bank. Finally, we demonstrate on a protein-protein docking reference data set the impact of virtual cross-links on protein docking calculations and show that an inter-protein cross-link can reduce on average the RMSD of a docking prediction by 5.0 Å. The methods and results presented here provide guidelines for the effective integration of chemical cross-link data in molecular modeling calculations and should advance the structural analysis of particularly large and transient protein complexes via hybrid structural biology methods.

  20. Link prediction in the network of global virtual water trade

    Science.gov (United States)

    Tuninetti, Marta; Tamea, Stefania; Laio, Francesco; Ridolfi, Luca

    2016-04-01

    Through the international food-trade, water resources are 'virtually' transferred from the country of production to the country of consumption. The international food-trade, thus, implies a network of virtual water flows from exporting to importing countries (i.e., nodes). Given the dynamical behavior of the network, where food-trade relations (i.e., links) are created and dismissed every year, link prediction becomes a challenge. In this study, we propose a novel methodology for link prediction in the virtual water network. The model aims at identifying the main factors (among 17 different variables) driving the creation of a food-trade relation between any two countries, along the period between 1986 and 2011. Furthermore, the model can be exploited to investigate the network configuration in the future, under different possible (climatic and demographic) scenarios. The model grounds the existence of a link between any two nodes on the link weight (i.e., the virtual water flow): a link exists when the nodes exchange a minimum (fixed) volume of virtual water. Starting from a set of potential links between any two nodes, we fit the associated virtual water flows (both the real and the null ones) by means of multivariate linear regressions. Then, links with estimated flows higher than a minimum value (i.e., threshold) are considered active-links, while the others are non-active ones. The discrimination between active and non-active links through the threshold introduces an error (called link-prediction error) because some real links are lost (i.e., missed links) and some non-existing links (i.e., spurious links) are inevitably introduced in the network. The major drivers are those significantly minimizing the link-prediction error. Once the structure of the unweighted virtual water network is known, we apply, again, linear regressions to assess the major factors driving the fluxes traded along (modelled) active-links. Results indicate that, on the one hand

  1. Bezafibrate for X-linked adrenoleukodystrophy.

    Directory of Open Access Journals (Sweden)

    Marc Engelen

    Full Text Available X-linked adrenoleukodystrophy (X-ALD is caused by mutations in the ABCD1 gene and is characterized by impaired beta-oxidation of very-long-chain fatty acids (VLCFA and subsequent VLCFA accumulation in tissues. In adulthood X-ALD most commonly manifests as a gradually progressive myelopathy, (adrenomyeloneuropathy; AMN without any curative or disease modifying treatments. We recently showed that bezafibrate (BF, a drug used for the treatment of hyperlipidaemia, reduces VLCFA accumulation in X-ALD fibroblasts by inhibiting ELOVL1, an enzyme involved in the VLCFA synthesis. We therefore designed a proof-of-principal clinical trial to determine whether BF reduces VLCFA levels in plasma and lymphocytes of X-ALD patients. Ten males with AMN were treated with BF for 12 weeks at a dose of 400 mg daily, followed by 12 weeks of 800 mg daily. Every 4 weeks patients were evaluated for side effects and blood samples were taken for analysis. Adherence was good as indicated by a clear reduction in triglycerides. There was no reduction in VLCFA in either plasma or lymphocytes. Plasma levels of BF did not exceed 25 µmol/L. We concluded that BF, at least in the dose given, is unable to lower VLCFA levels in plasma or lymphocytes in X-ALD patients. It is unclear whether this is due to the low levels of BF reached in plasma. Our future work is aimed at the identification of highly-specific inhibitors of ELOVL1 that act at much lower concentrations than BF and are well tolerated. BF appears to have no therapeutic utility in X-ALD.ClinicalTrials.gov NCT01165060.

  2. Oral microbiome link to neurodegeneration in glaucoma.

    Directory of Open Access Journals (Sweden)

    Konstantin Astafurov

    Full Text Available BACKGROUND: Glaucoma is a progressive optic nerve degenerative disease that often leads to blindness. Local inflammatory responses are implicated in the pathology of glaucoma. Although inflammatory episodes outside the CNS, such as those due to acute systemic infections, have been linked to central neurodegeneration, they do not appear to be relevant to glaucoma. Based on clinical observations, we hypothesized that chronic subclinical peripheral inflammation contributes to neurodegeneration in glaucoma. METHODS: Mouthwash specimens from patients with glaucoma and control subjects were analyzed for the amount of bacteria. To determine a possible pathogenic mechanism, low-dose subcutaneous lipopolysaccharide (LPS was administered in two separate animal models of glaucoma. Glaucomatous neurodegeneration was assessed in the retina and optic nerve two months later. Changes in gene expression of toll-like receptor 4 (TLR4 signaling pathway and complement as well as changes in microglial numbers and morphology were analyzed in the retina and optic nerve. The effect of pharmacologic blockade of TLR4 with naloxone was determined. FINDINGS: Patients with glaucoma had higher bacterial oral counts compared to control subjects (p<0.017. Low-dose LPS administration in glaucoma animal models resulted in enhancement of axonal degeneration and neuronal loss. Microglial activation in the optic nerve and retina as well as upregulation of TLR4 signaling and complement system were observed. Pharmacologic blockade of TLR4 partially ameliorated the enhanced damage. CONCLUSIONS: The above findings suggest that the oral microbiome contributes to glaucoma pathophysiology. A plausible mechanism by which increased bacterial loads can lead to neurodegeneration is provided by experiments in animal models of the disease and involves activation of microglia in the retina and optic nerve, mediated through TLR4 signaling and complement upregulation. The finding that commensal

  3. Methane oxidation linked to chlorite dismutation

    Science.gov (United States)

    Miller, Laurence G.; Baesman, Shaun M.; Carlström, Charlotte I.; Coates, John D.; Oremland, Ronald S.

    2014-01-01

    We examined the potential for CH4 oxidation to be coupled with oxygen derived from the dissimilatory reduction of perchlorate, chlorate, or via chlorite (ClO−2) dismutation. Although dissimilatory reduction of ClO−4 and ClO−3 could be inferred from the accumulation of chloride ions either in spent media or in soil slurries prepared from exposed freshwater lake sediment, neither of these oxyanions evoked methane oxidation when added to either anaerobic mixed cultures or soil enriched in methanotrophs. In contrast, ClO−2 amendment elicited such activity. Methane (0.2 kPa) was completely removed within several days from the headspace of cell suspensions of Dechloromonas agitata CKB incubated with either Methylococcus capsulatus Bath or Methylomicrobium album BG8 in the presence of 5 mM ClO−2. We also observed complete removal of 0.2 kPa CH4 in bottles containing soil enriched in methanotrophs when co-incubated with D. agitata CKB and 10 mM ClO−2. However, to be effective these experiments required physical separation of soil from D. agitata CKB to allow for the partitioning of O2 liberated from chlorite dismutation into the shared headspace. Although a link between ClO−2 and CH4 consumption was established in soils and cultures, no upstream connection with either ClO−4 or ClO−3 was discerned. This result suggests that the release of O2 during enzymatic perchlorate reduction was negligible, and that the oxygen produced was unavailable to the aerobic methanotrophs.

  4. Alexander quandle lower bounds for link genera

    CERN Document Server

    Benedetti, Riccardo

    2011-01-01

    We denote by Q_F the family of the Alexander quandle structures supported by finite fields. For every k-component oriented link L, every partition P of L into h:=|P| sublinks, and every labelling z of such a partition by the natural numbers z_1,...,z_n, the number of X-colorings of any diagram of (L,z) is a well-defined invariant of (L,P), of the form q^(a_X(L,P,z)+1) for some natural number a_X(L,P,z). Letting X and z vary in Q_F and among the labellings of P, we define a derived invariant A_Q(L,P)=sup a_X(L,P,z). If P_M is such that |P_M|=k, we show that A_Q(L,P_M) is a lower bound for t(L), where t(L) is the tunnel number of L. If P is a "boundary partition" of L and g(L,P) denotes the infimum among the sums of the genera of a system of disjoint Seifert surfaces for the L_j's, then we show that A_Q(L,P) is at most 2g(L,P)+2k-|P|-1. We set A_Q(L):=A_Q(L,P_m), where |P_m|=1. By elaborating on a suitable version of a result by Inoue, we show that when L=K is a knot then A_Q(K) is bounded above by A(K), where ...

  5. Acute pancreatitis and fibromyalgia: Cytokine link

    Directory of Open Access Journals (Sweden)

    Sadat Muzammil

    2011-01-01

    Full Text Available Context: Fibromyalgia is a widespread musculoskeletal pain disorder found in 2% of the general population and with a preponderance of 85% in females, and has both genetic and environmental contribution. Acute pancreatitis is a severe condition and in most cases gallstones disease represents approximately half of the cases of acute pancreatitis, and 20-25% are related to alcohol abuse. Small numbers of cases are caused by a variety of other reasons but a few cases have no obvious cause, referred to as ′idiopathic′. Here we present a case where fibromyalgia might be linked to acute pancreatitis. We believe this has not been reported in this context in literature. Case Report: Fibromyalgia is a widespread musculoskeletal pain disorder found in 2% of the general population and with a preponderance of 85% in females, and has both genetic and environmental contribution. Patient had a cholecystectomy eight years previously. Patient feels tired almost all the time due to her fibromyalgia and requires family support for daily routine. Patient′s blood results showed alanine transaminase 527 IU/L, alkaline phosphatase 604 IU/L, bilirubin 34 μmol/L, amylase 2257 IU/L, C-reactive protein 19 mg/L, Gamma-Glutamyl transpeptidase 851 IU/L, renal function and electrolytes were within normal limits. The patient was admitted to the high dependency unit with a diagnosis of acute pancreatitis. Conclusion: There is a known increase in levels of cytokines in patients with fibromyalgia. Part of the pathophysiology of acute pancreatitis is related to raised cytokines and immune deregulations. We hypothesize that elevated levels of cytokines in fibromyalgia has led to acute pancreatitis in our patient. Further epidemiological research on the incidence of pancreatitis in cytokine mediated conditions such as fibromyalgia is required.

  6. Methane oxidation linked to chlorite dismutation.

    Directory of Open Access Journals (Sweden)

    Laurence G. Miller

    2014-06-01

    Full Text Available We examined the potential for CH4 oxidation to be coupled with oxygen derived from the dissimilatory reduction of perchlorate, chlorate or via chlorite (ClO2- dismutation. Although dissimilatory reduction of ClO4- and ClO3- could be inferred from the accumulation of chloride ions either in spent media or in soil slurries prepared from exposed freshwater lake sediment, neither of these oxyanions evoked methane oxidation when added to either anaerobic mixed cultures or soil enriched in methanotrophs. In contrast, ClO2- amendment elicited such activity. Methane (0.2 kPa was completely removed within several days from the headspace of cell suspensions of Dechloromonas agitata CKB incubated with either Methylococcus capsulatus Bath or Methylomicrobium album BG8 in the presence of 5 mM ClO2-. We also observed complete removal of 0.2 kPa CH4 in bottles containing soil enriched in methanotrophs when co-incubated with D. agitata CKB and 10 mM ClO2-. However, to be effective these experiments required physical separation of soil from D. agitata CKB to allow for the partitioning of O2 liberated from chlorite dismutation into the shared headspace. Although a link between ClO2- and CH4 consumption was established in soils and cultures, no upstream connection with either ClO4- or ClO3- was discerned. This result suggests that the release of O2 during enzymatic perchlorate reduction was negligible, and that the oxygen produced was unavailable to the aerobic methanotrophs.

  7. Accelerating coordination in temporal networks by engineering the link order

    Science.gov (United States)

    Masuda, Naoki

    2016-02-01

    Social dynamics on a network may be accelerated or decelerated depending on which pairs of individuals in the network communicate early and which pairs do later. The order with which the links in a given network are sequentially used, which we call the link order, may be a strong determinant of dynamical behaviour on networks, potentially adding a new dimension to effects of temporal networks relative to static networks. Here we study the effect of the link order on linear coordination (i.e., synchronisation) dynamics. We show that the coordination speed considerably depends on specific orders of links. In addition, applying each single link for a long time to ensure strong pairwise coordination before moving to a next pair of individuals does not often enhance coordination of the entire network. We also implement a simple greedy algorithm to optimise the link order in favour of fast coordination.

  8. CSIR at INEX 2008 Link-the-Wiki Track

    Science.gov (United States)

    Lu, Wei; Liu, Dan; Fu, Zhenzhen

    In this paper, we describe methods taken by CSIR in the INEX 2008 Link-the-Wiki track. For the incoming link detection, we use p(d|t), the probability to generate a document, when given the topic file, to judge which documents are proper link sources for the given topic. For the file-to-file task of outgoing link detection, we take a two-step approach: first, we identify a group of candidate target documents by literally matching the topic file title and document content; then, candidate documents are ranked by the number of incoming links. For the anchor-to-BEP task, we use p(d|a,t), the probability to generate a document, when given the topic file and an anchor name, to select anchors and link targets for a given topic.

  9. Enhancing complex network controllability by minimum link direction reversal

    Science.gov (United States)

    Hou, Lvlin; Lao, Songyang; Small, Michael; Xiao, Yandong

    2015-07-01

    Controllability of complex networks has recently become one of the most popular research fields, but the importance of link direction for controllability has not been systematically considered. We propose a method to enhance controllability of a directed network by changing the direction of a small fraction of links while keeping the total number of links unchanged. The main idea of the method is to find candidate links based on the matching path. Extensive numerical simulation on many modeled networks demonstrates that this method is effective. Furthermore, we find that the nodes linked to candidate links have a distinct character, which provide us with a strategy to improve the controllability based on the local structure. Since the whole topology of many real networks is not visible and we only get some local structure information, this strategy is potentially more practical compared to those that demand complete topology information.

  10. Shuttle/TDRSS modelling and link simulation study

    Science.gov (United States)

    Braun, W. R.; Mckenzie, T. M.; Biederman, L.; Lindsey, W. C.

    1979-01-01

    A Shuttle/TDRSS S-band and Ku-band link simulation package called LinCsim was developed for the evaluation of link performance for specific Shuttle signal designs. The link models were described in detail and the transmitter distortion parameters or user constraints were carefully defined. The overall link degradation (excluding hardware degradations) relative to an ideal BPSK channel were given for various sets of user constraint values. The performance sensitivity to each individual user constraint was then illustrated. The effect of excessive Spacelab clock jitter on the return link BER performance was also investigated as was the problem of subcarrier recovery for the K-band Shuttle return link signal.

  11. Dispersion penalty analysis for VSR-1 optical links

    Institute of Scientific and Technical Information of China (English)

    JIA Jiu-chun; CHEN Hong-da; CHEN Xiong-bin; ZHOU Yi

    2006-01-01

    This paper presents an approach to calculate dispersion penalty for VSR-1 optical links.Based on parameters of a specific VSR-1 link,dispersion penalties are computed for various modal dispersion bandwidths respectively.The worst-case eye closure is expressed numerically by using the signal waveform at time 0,and the signal waveform is obtained in frequency domain through FFT algorithm.By this approach,the dispersion penalty is determined by the shape of transfer functions of the various components in the links.To simplify the derivation of multimode fiber link transfer function,a Gaussian form of normalized impulse response is used.This calculation approach can be used to estimate the worst-case dispersion penalty of VSR-1 links in the link budget analysis.

  12. Accelerating coordination in temporal networks by engineering the link order

    CERN Document Server

    Masuda, Naoki

    2015-01-01

    Social dynamics on a network may be accelerated or decelerated depending on which pairs of individuals in the network communicate early and which pairs do later. The order with which the links in a given network are sequentially used, which we call the link order, may be a strong determinant of dynamical behaviour on networks, potentially adding a new dimension to effects of temporal networks relative to static networks. Here we study the effect of the link order on linear synchronisation dynamics. We show that the synchronisation speed considerably depends on specific orders of links. In addition, applying each single link for a long time to ensure strong pairwise synchronisation before moving to a next pair of individuals does not often enhance synchronisation of the entire network. We also implement a simple greedy algorithm to optimise the link order in favour of fast synchronisation.

  13. Identification of hybrid node and link communities in complex networks

    Science.gov (United States)

    He, Dongxiao; Jin, Di; Chen, Zheng; Zhang, Weixiong

    2015-03-01

    Identifying communities in complex networks is an effective means for analyzing complex systems, with applications in diverse areas such as social science, engineering, biology and medicine. Finding communities of nodes and finding communities of links are two popular schemes for network analysis. These schemes, however, have inherent drawbacks and are inadequate to capture complex organizational structures in real networks. We introduce a new scheme and an effective approach for identifying complex mixture structures of node and link communities, called hybrid node-link communities. A central piece of our approach is a probabilistic model that accommodates node, link and hybrid node-link communities. Our extensive experiments on various real-world networks, including a large protein-protein interaction network and a large network of semantically associated words, illustrated that the scheme for hybrid communities is superior in revealing network characteristics. Moreover, the new approach outperformed the existing methods for finding node or link communities separately.

  14. Predicting top-L missing links with node and link clustering information in large-scale networks

    Science.gov (United States)

    Wu, Zhihao; Lin, Youfang; Wan, Huaiyu; Jamil, Waleed

    2016-08-01

    Networks are mathematical structures that are universally used to describe a large variety of complex systems, such as social, biological, and technological systems. The prediction of missing links in incomplete complex networks aims to estimate the likelihood of the existence of a link between a pair of nodes. Various topological features of networks have been applied to develop link prediction methods. However, the exploration of features of links is still limited. In this paper, we demonstrate the power of node and link clustering information in predicting top -L missing links. In the existing literature, link prediction algorithms have only been tested on small-scale and middle-scale networks. The network scale factor has not attracted the same level of attention. In our experiments, we test the proposed method on three groups of networks. For small-scale networks, since the structures are not very complex, advanced methods cannot perform significantly better than classical methods. For middle-scale networks, the proposed index, combining both node and link clustering information, starts to demonstrate its advantages. In many networks, combining both node and link clustering information can improve the link prediction accuracy a great deal. Large-scale networks with more than 100 000 links have rarely been tested previously. Our experiments on three large-scale networks show that local clustering information based methods outperform other methods, and link clustering information can further improve the accuracy of node clustering information based methods, in particular for networks with a broad distribution of the link clustering coefficient.

  15. Scaling of fat-link irrelevant-clover fermions

    CERN Document Server

    Zanotti, J M; Leinweber, D B; Williams, A G; 10.1103/PhysRevD.71.034510

    2005-01-01

    Hadron masses are calculated in quenched lattice QCD on a variety of lattices in order to probe the scaling behavior of the Fat-Link Irrelevant Clover (FLIC) fermion action, a fat-link clover fermion action in which the purely irrelevant operators of the fermion action are constructed using APE-smeared links. The scaling analysis indicates FLIC fermions provide a new form of nonperturbative O(a) improvement where near-continuum results are obtained at finite lattice spacing.

  16. MODELLING THE GUARANTEE LIABILITY UNDER UNIT-LINKED CONTRACTS

    OpenAIRE

    Cristina CIUMAȘ; Diana-Maria CHIȘ

    2015-01-01

    Unit-linked contracts are wrapped with some death, maturity and accumulation guarantees such as the guaranteed minimum maturity benefit, the guaranteed minimum death benefit, the guaranteed minimum accumulation benefit, the guaranteed minimum income benefit, and/or the guaranteed minimum surrender benefit. According to Romanian legislation which regulates the unit-linked life insurance market, unit-linked life insurance contracts pass most of the investment risk to the policyholder and involv...

  17. Mechanisms Underlying the Link between Cannabis Use and Prospective Memory

    OpenAIRE

    Carrie Cuttler; McLaughlin, Ryan J.; Peter Graf

    2012-01-01

    While the effects of cannabis use on retrospective memory have been extensively examined, only a limited number of studies have focused on the links between cannabis use and prospective memory. We conducted two studies to examine the links between cannabis use and both time-based and event-based prospective memory as well as potential mechanisms underlying these links. For the first study, 805 students completed an online survey designed to assess cannabis consumption, problems with cannabis ...

  18. Milnor open books of links of some rational surface singularities

    OpenAIRE

    Özbağcı, Burak; Bhupal, Mohan

    2011-01-01

    Pacific Journal of Mathematics MILNOR OPEN BOOKS OF LINKS OF SOME RATIONAL SURFACE SINGULARITIES MOHAN BHUPAL AND BURAK OZBAGCI Volume 254 No. 1 November 2011 PACIFIC JOURNAL OF MATHEMATICS Vol. 254, No. 1, 2011 MILNOR OPEN BOOKS OF LINKS OF SOME RATIONAL SURFACE SINGULARITIES MOHAN BHUPAL AND BURAK OZBAGCI We determine Legendrian surgery diagrams for the canonical contact struc-tures of links of rational surface singularities that are also small Seifert...

  19. Industrial applications of different methods of cross-linking polyethylene

    International Nuclear Information System (INIS)

    The temperature limits for the continuous and temporary overload operation of cables insulated with low density polyethylene are increased very significantly if the polymer is cross-linked. Two free-radical cross-linking processes, one based on high temperature peroxide vulcanisation and the other on the low temperature cure of an alkoxy silane condensation, are described and compared with radiation induced cross-linking in cable manufacture. (author)

  20. Deterministic linear optics quantum computation utilizing linked photon circuits

    CERN Document Server

    Yoran, N; Yoran, Nadav; Reznik, Benni

    2003-01-01

    We suggest an efficient scheme for quantum computation with linear optical elements utilizing "linked" photon states. The linked states are designed according to the particular quantum circuit one wishes to process. Once a linked-state has been successfully prepared, the computation is pursued deterministically by a sequence of teleportation steps. The present scheme enables a significant reduction of the average number of elementary gates per logical gate to about 20-30 CZ_{9/16} gates.

  1. BlueFinder: Recommending Wikipedia Links Using DBpedia Properties

    OpenAIRE

    Torres, Diego; Skaf-Molli, Hala; Molli, Pascal; Diaz, Alicia

    2013-01-01

    DBpedia knowledge base has been built from data extracted from Wikipedia. However, many existing relations among resources in DBpedia are missing links among articles from Wikipedia. In some cases, adding these links into Wikipedia will enrich Wikipedia content and therefore will enable bet- ter navigation. In previous work, we proposed PIA algorithm that predicts the best link to connect two articles in Wikipedia corresponding to those related by a semantic property in DB- pedia and respecti...

  2. Incites into Citation Linking using the OAI-PMH

    CERN Document Server

    CERN. Geneva

    2005-01-01

    deposit process. This highly-distributed approach to citation linking utilises the OAI-PMH to transfer structured citation data between IRs and citation indexing services. OpenURL - a standard for contextual linking using bibliographic data - is now a NISO standard. As well as it's linking role, OpenURL is a useful standard for the transfer of bibliographic data for the purposes of...

  3. Link Perdurability Based Routing for Mobile Ad Hoc Networks

    Institute of Scientific and Technical Information of China (English)

    Sun Xuebin; Zhou Zheng

    2003-01-01

    Ad Hoc networks are prone to link failures due to mobility. In this letter, a link perdurability based routing scheme is proposed to try dealing with this problem. This scheme uses signal strength measurements to estimate the route life time and hence chooses a stable route, and is implemented in two typical ad hoc routing protocols to evaluate its performance. The simulation results have shown that this scheme can improve these protocols' packet delivery ratio in cases where there are frequent link failures.

  4. Deliverable 3.2. EU Project Open Science Link

    OpenAIRE

    Hugelier, Sara; Janssens, Marie-Christine; Van den Boom, Freya; Verhenneman, Griet

    2015-01-01

    The objective of this deliverable is to clarify the legal state of the art and rules applicable to the OpenScienceLink project and to ensure that the development and workings of the OpenScienceLink platform are compatible with the different regulatory frameworks This deliverable should provide a clear description and explanation of the applicable legal framework to the OpenScienceLink platform, and more in general, the legal aspects of open access to research data.

  5. Tracing where and who provenance in Linked Data: a calculus

    OpenAIRE

    Dezani, Mariangiola; Horne, Ross; Sassone, Vladimiro

    2012-01-01

    Linked Data provides some sensible guidelines for publishing and consuming data on the Web. Data published on the Web has no inherent truth, yet its quality can often be assessed based on its provenance. This work introduces a new approach to provenance for Linked Data. The simplest notion of provenance-viz., a named graph indicating where the data is now-is extended with a richer provenance format. The format reflects the behaviour of processes interacting with Linked Data, tracing where the...

  6. Link Expiration Time-Aware Routing Protocol for UWSNs

    OpenAIRE

    Md. Ashraf Uddin; Mamun-or-Rashid

    2013-01-01

    We propose a link expiration time-aware routing protocol for UWSNs. In this protocol, a sending node forwards a data packet after being sure that the packet reaches the forwarding node, and acknowledgment is returned to the sending node after receiving the data packet. Node mobility is handled in the protocol through the calculation of the link expiration time and sending the packet based on the link expiration time. Although the protocol employs two types of control packet, it provides less ...

  7. FSO and radio link attenuation: meteorological models verified by experiment

    Science.gov (United States)

    Brazda, Vladimir; Fiser, Ondrej; Svoboda, Jaroslav

    2011-09-01

    Institute of Atmospheric Physics of Czech Academy measures atmospheric attenuation on 60 m experimental FSO link on 830 and 1550 nm for more than three years. Visibility sensors and two 3D sonic anemometers on both transmitting and receiving site, rain gauge and many sensors enabling the refractivity index computation are spaced along the optical link. Meteorological visibility, wind turbulent energy, sonic temperature, structure index and rain rate are correlated with measured attenuation. FSO link attenuation dependence on the above mentioned parameters is analyzed. The paper shows also basic statistical behavior of the long-term FSO signal level and also the simulation of hybrid link techniques.

  8. Influence of propagation in digital wireless beam, microwave links

    Science.gov (United States)

    Bursztejn, J.

    1984-10-01

    Methods are presented for determining the parameters which permit the prediction of the quality of tropospheric scattering and line of sight microwave links. Wireless beam, microwave links with tropospheric scattering are considered based on experiments for determining the coherence band which is the essential parameter for digital transmission by tropospheric scattering. The effects of propagation difficulties in line of sight links are discussed with focus on depolarization and selective fading. Experimental results are given which permit calculating the sensitivity of equipment and predicting the quality of the links.

  9. Link prediction on evolving graphs using matrix and tensor factorizations.

    Energy Technology Data Exchange (ETDEWEB)

    Dunlavy, Daniel M.; Acar, Evrim (Turkish National Research Institute of Electronics and Cryptology); Kolda, Tamara Gibson

    2010-06-01

    The data in many disciplines such as social networks, web analysis, etc. is link-based, and the link structure can be exploited for many different data mining tasks. In this paper, we consider the problem of temporal link prediction: Given link data for time periods 1 through T, can we predict the links in time period T + 1? Specifically, we look at bipartite graphs changing over time and consider matrix- and tensor-based methods for predicting links. We present a weight-based method for collapsing multi-year data into a single matrix. We show how the well-known Katz method for link prediction can be extended to bipartite graphs and, moreover, approximated in a scalable way using a truncated singular value decomposition. Using a CANDECOMP/PARAFAC tensor decomposition of the data, we illustrate the usefulness of exploiting the natural three-dimensional structure of temporal link data. Through several numerical experiments, we demonstrate that both matrix- and tensor-based techniques are effective for temporal link prediction despite the inherent difficulty of the problem.

  10. An Obstruction to Embedding 4-Tangles in Links

    OpenAIRE

    Krebes, David A.

    1999-01-01

    We consider the ways in which a 4-tangle T inside a unit cube can be extended outside the cube into a knot or link L. We present two links n(T) and d(T) such that the greatest common divisor of the determinants of these two links always divides the determinant of the link L. In order to prove this result we give a two-integer invariant of 4-tangles. Calculations are facilitated by viewing the determinant as the Kauffman bracket at a fourth root of -1, which sets the loop factor to zero. For r...

  11. LinkedIn Marketing An Hour a Day

    CERN Document Server

    von Rosen, Viveka

    2012-01-01

    A step-by-step guide for succeeding on the for ''business'' social media network LinkedIn Marketing: An Hour a Day helps you create, customize, and optimize a presence on LinkedIn, the world's largest social network for professionals. In this detailed, step-by-step book, LinkedIn expert Viveka von Rosen reveals how to use this powerful platform to ensure that you or your company get noticed by the right audience. Discover previously undocumented tips and tricks for community growth and management, including how to best use Groups, events, and other LinkedIn features and applications. Offers a

  12. The braid index of complicated DNA polyhedral links.

    Directory of Open Access Journals (Sweden)

    Xiao-Sheng Cheng

    Full Text Available The goal of this paper is to determine the braid index of two types of complicated DNA polyhedral links introduced by chemists and biologists in recent years. We shall study it in a more broad context and actually consider so-called Jaeger's links (more general Traldi's links which contain, as special cases, both four types of simple polyhedral links whose braid indexes have been determined and the above two types of complicated DNA polyhedral links. Denote by b(L and c(L the braid index and crossing number of an oriented link L, respectively. Roughly speaking, in this paper, we prove that b(L = c(L/2 + 1 for any link L in a family including Jaeger's links and contained in Traldi's links, which is obtained by combining the MFW inequality and an Ohyama's result on upper bound of the braid index. Our result may be used to to characterize and analyze the structure and complexity of DNA polyhedra and entanglement in biopolymers.

  13. Temporal Link Prediction using Matrix and Tensor Factorizations

    CERN Document Server

    Dunlavy, Daniel M; Acar, Evrim

    2010-01-01

    The data in many disciplines such as social networks, web analysis, etc. is link-based, and the link structure can be exploited for many different data mining tasks. In this paper, we consider the problem of temporal link prediction: Given link data for times 1 through T, can we predict the links at time T+1? If our data has underlying periodic structure, can we predict out even further in time, i.e., links at time T+2, T+3, etc.? In this paper, we consider bipartite graphs that evolve over time and consider matrix- and tensor-based methods for predicting future links. We present a weight-based method for collapsing multi-year data into a single matrix. We show how the well-known Katz method for link prediction can be extended to bipartite graphs and, moreover, approximated in a scalable way using a truncated singular value decomposition. Using a CANDECOMP/PARAFAC tensor decomposition of the data, we illustrate the usefulness of exploiting the natural three-dimensional structure of temporal link data. Through...

  14. Continuum model for linked fibers with alignment interactions

    OpenAIRE

    Degond, Pierre; Delebecque, Fanny; Peurichard, Diane

    2015-01-01

    We introduce an individual-based model for fiber elements having the ability to cross-link or unlink each other and to align with each other at the cross links. We first formally derive a kinetic model for the fiber and cross-links distribution functions. We then consider the fast linking/unlinking regime in which the model can be reduced to the fiber distribution function only and investigate its diffusion limit. The resulting macroscopic model consists of a system of nonlinear diffusion equ...

  15. The science teacher as the organic link

    Science.gov (United States)

    Alexakos, Konstantinos

    2007-10-01

    This study began as an exploration of the following questions: What do individual science teachers bring into their teaching that frames and mediates their teaching philosophy and of what, if any, value is it in science education? Drawing from a life history case study of Anna, an in-service science teacher, I show that her moral beliefs, perceptions, experiences, and interests dialectically frame and mediate her views of science teaching. Anna brings into her classroom her personal philosophy of teaching and learning. This is in contrast to studies concluding that different aspects of teachers' personal philosophies, such as their understanding of the nature of science and their behavior and pedagogical decisions are not connected and may be neatly segregated from one another. In the "transmission" [Transmission is presented in quotes because in this manuscript it is used dialectically, as opposed to a one-directional and "objective" process. The science teacher is not just a "lens" for the transmission of cultural capital; the cultural capital "transmitted" though Anna is seen as existing in a state of creation/recreation.] of cultural capital, Anna embodies dialectical relationships and processes, not just as a mediator of culture, but also as an organic entity that contributes to how culture is created, recreated and exchanged in a science classroom, and as such, is referred to here as an organic link. Science teacher identity and science teaching philosophy are thus seen as much closer to the human experience—merging the intellectual, the personal, the cultural, the political, and the environmental with the relationships and the processes that connect each to the others and to the whole. They are viewed as, at once, being mediated by as well as mediating one another. I argue that the total of what science teaching is exceeds the sum of its commonly "measurable" parts, like content and pedagogical knowledge. Although the designing and framing of this study

  16. LINK PREDICTION MODEL FOR PAGE RANKING OF BLOGS

    Directory of Open Access Journals (Sweden)

    S.Geetha

    2012-11-01

    Full Text Available Social Network Analysis is mapping and measuring of relationships and flows of information between people, organizations, computers, or other information or knowledge processing entities. Social media systems such as blogs, LinkedIn, you tube are allows users to share content media, etc. Blog is a social network notepad service with consider on user interactions. In this paper study the link predictionand page ranking using MozRank algorithm using blog websites. It finds out how all the websites on the internet link to each other with the largest Link Intelligence database. As link data is also a component of search engine ranking, understanding the link profile of Search Engine positioning. Here the MozRank algorithm is using backlinks from blog websites and linking websites quality. Good websites with many backlinks which linking the corresponding WebPage give highly value of MozRank. MozRank can be improved a web page's by getting lots of links from semi-popular pages or a few links from very popular pages. The algorithm for page ranking must work differently and MozRank is more comprehensive and accurate than Goggle’s page rank. Another tool is Open Site Explorer that is ability to compare five URL's against each other. Open Site Explorer’s Compare Link Metrics option is how one measures pagelevel metrics, the other domain. This result can help to generate a chart form for the comparative URLs. A comparison chart of the important metrics for these pages is shown which makes it very clear and easy to compare the data between the five URL's.

  17. First two ALMA antennas successfully linked

    Science.gov (United States)

    2009-05-01

    Scientists and engineers working on the world's largest ground-based astronomical project, the Atacama Large Millimeter/submillimeter Array (ALMA), have achieved another milestone -- the successful linking of two ALMA astronomical antennas, synchronised with a precision of one millionth of a millionth of a second -- to observe the planet Mars. ALMA is under construction by an international partnership in the Chilean Andes. ESO PR Photo 18a/09 The two ALMA antennas On 30 April, the team observed the first "interferometric fringes" of an astronomical source by linking two 12-metre diameter ALMA antennas, together with the other critical parts of the system. Mars was chosen as a suitable target for the observations, which demonstrate ALMA's full hardware functionality and connectivity. This important milestone was achieved at the ALMA Operations Support Facility, high in Chile's Atacama region, at an altitude of 2900 metres. "We're very proud and excited to have made this crucial observation, as it proves that the various hardware components work smoothly together. This brings us another step closer to full operations for ALMA as an astronomical observatory," says Wolfgang Wild, the European ALMA Project Manager. The two antennas used in this test will be part of ALMA's array of 66 giant 12-metre and 7-metre diameter antennas that will observe in unison as a single giant telescope, under construction on the Chajnantor plateau above the Operations Support Facility, at an altitude of 5000 metres. ALMA will operate as an interferometer, capturing millimetre and submillimetre wavelength signals from the sky with multiple antennas, and combining them to create extremely high resolution images, similar to those that would be obtained by a single, giant antenna with a diameter equal to the distance between the antennas used. "This can only be achieved with the perfect synchronisation of the antennas and the electronic equipment: a precision much better than one millionth of

  18. 3H-collagen turnover in non-cross-linked and aldehyde-cross-linked dermal collagen grafts.

    OpenAIRE

    Oliver, R. F.; Barker, H; Cooke, A.; L. Stephen

    1982-01-01

    Using trypsin-purified rat dermal collagen labelled with tritiated hydroxyproline and proline, a study has been made of hydroxyproline turnover in non-cross-linked and glutaraldehyde- and formaldehyde-cross-linked collagen when implanted s.c. in unlabelled isogenic rats. Grafts cross-linked with 0.01% glutaraldehyde maintained their collagen mass over a 22-week period, loss of original collagen being balanced by the gain in new collagen (22% at 22 weeks). Cross-linking with 5% formaldehyde te...

  19. X-Ray Diffraction Studies of Cross Linked Chitosan With Different Cross Linking Agents For Waste Water Treatment Application

    Science.gov (United States)

    Julkapli, Nurhidayatullaili Muhd; Ahmad, Zulkifli; Akil, Hazizan Md

    2010-01-01

    Chitosan is a polysaccharide derived from N-deacetylation of chitin and receiving increased attention as metal ion absorbent in wastewater treatment application. To improve the performance of chitosan as an absorbent, the cross linking approach was applied. Introduction of cross-linking agent would break the crystal zone in chitosan system, making it less crystal and consequently enhanced the absorption area. Therefore, in this study, cross-linked chitosan were prepared using different of cross-linking agents. The chitosan powder was weighed, dissolved in acetic acid (0.1 M), and dropped slowly into absolute N-methyl pyyrolidone solvent containing cross-linking agent. The cross linking reaction was carried out in N2 environment at 150° C for 6 hours. X-ray diffraction (XRD) analysis was applied to characterize the crystallinity of native and cross linked chitosan. Generally, the XRD patterns of all types of chitosan show two crystalline peaks approximately at 10° and 20° (2θ). However, the cross linked chitosan with longer length of cross linking agents show lower and broader crystalline peaks as compare to those with shorter length. Similarly, the calculated crystalline index (Cr I) also showed this decreasing tendency.

  20. The missing links to link ubiquitin: Methods for the enzymatic production of polyubiquitin chains.

    Science.gov (United States)

    Faggiano, Serena; Alfano, Caterina; Pastore, Annalisa

    2016-01-01

    Attachment of ubiquitin (Ub) as monoUb and polyUb chains of different lengths and linkages to proteins plays a dominant role in very different regulatory mechanisms. Therefore, the study of polyUb chains has assumed a central interest in biochemistry and structural biology. An essential step necessary to allow in vitro biochemical and structural studies of polyUbs is the production of their chains in high quantities and purity. This is not always an easy task and can be achieved both enzymatically and chemically. Previous reviews have covered chemical cross-linking exhaustively. In this review, we concentrate on the different approaches developed so far for the enzymatic production of different Ub chains. These strategies permit a certain flexibility in the production of chains with various linkages and lengths. We critically describe the available methods and comment on advantages and limitations. It is clear that the field is mature to study most of the possible links, but some more work needs to be done to complete the picture and to exploit the current methodologies for understanding in full the Ub code.