WorldWideScience

Sample records for carbohydrates medical aspects

  1. [Medical aspects of fasting].

    Science.gov (United States)

    Gavrankapetanović, F

    1997-01-01

    Fasting (arabic-savm) was proclaimed through islam, and thus it is an obligation for Holly Prophet Muhammad s.a.v.s.-Peace be to Him-in the second year after Hijra (in 624 after Milad-born of Isa a.s.). There is a month of fasting-Ramadan-each lunar (hijra) year. So, it was 1415th fasting this year. Former Prophets have brought obligative messages on fasting to their people; so there are also certain forms of fasting with other religions i.e. with Catholics, Jews, Orthodox. These kinds of fasting above differ from muslim fasting, but they also appear obligative. All revelations have brought fasting as obligative. From medical point of view, fasting has two basical components: psychical and physical. Psychical sphere correlate closely with its fundamental ideological message. Allah dz.s. says in Quran: "... Fasting is obligative for you, as it was obligative to your precedents, as to avoid sins; during very few days (II, II, 183 & 184)." Will strength, control of passions, effort and self-discipline makes a pure faithfull person, who purify its mind and body through fasting. Thinking about The Creator is more intensive, character is more solid; and spirit and will get stronger. We will mention the hadith saying: "Essaihune humus saimun!" That means: "Travellers at the Earth are fasters (of my ummet)." The commentary of this hadith, in the Collection of 1001 hadiths (Bin bir hadis), number 485, says: "There are no travelling dervishs or monks in islam; thus there is no such a kind of relligousity in islam. In stead, it is changed by fasting and constant attending of mosque. That was proclaimed as obligation, although there were few cases of travelling in the name of relligousity, like travelling dervishs and sheichs." In this paper, the author discusses medical aspects of fasting and its positive characteristics in the respect of healthy life style and prevention of many sicks. The author mentions positive influence of fasting to certain system and organs of human

  2. Legal aspects of medical errors

    OpenAIRE

    Vučetić Čedomir S.; Vukašinović Zoran S.; Tulić Goran Dž.; Dulić Borivoje V.; Dimitrijević K.; Kalezić Nevena K.

    2011-01-01

    Healing people and medical care are together highly organized technological system with significant expert, ethical and legal regulative. Taking medical care is very sensitive area and it interfears deep into one’s integrity, so the law is necessary in this area as a regulator. The aim of work is to show medical errors from legal aspects and clinical practice. Errors, negligent conduct during the medical treatment and bad results of medical treatment are categories that can easily be sw...

  3. Medical physics: molecular aspects

    International Nuclear Information System (INIS)

    Actual problems in medical physics have been considered. Features in the cell membrane structure promoting the action of anticancer drugs are studied. The mechanism of an invasive method for measuring the blood pressure is analyzed. The tension distribution in the left ventricle wall was calculated. Conditions that prevent magnetic particles, nanodiamonds, and fullerene molecules, which are used to transport drugs in human body, to aggregate in liquid systems are determined. A molecular mechanism of electric welding of biological tissues has been proposed, as well as a method to study the surface of biological structures, by using ultrasound. The origin of structural changes in human hair under the influence of chemicals is determined

  4. Metabolic aspects of low carbohydrate diets and exercise

    Directory of Open Access Journals (Sweden)

    Peters Sandra

    2004-01-01

    Full Text Available Abstract Following a low carbohydrate diet, there is a shift towards more fat and less carbohydrate oxidation to provide energy to skeletal muscle, both at rest and during exercise. This review summarizes recent work on human skeletal muscle carbohydrate and fat metabolic adaptations to a low carbohydrate diet, focusing mainly on pyruvate dehydrogenase and pyruvate dehydrogenase kinase, and how these changes relate to the capacity for carbohydrate oxidation during exercise.

  5. Medical aspects of nuclear armament

    Energy Technology Data Exchange (ETDEWEB)

    Janse, M.J.; Schene, A.; Koch, K.

    1983-06-18

    The authors highlight a few medical, biological and psycological aspects of the use of nuclear weapons, drawing attention to their viewpoint that doctors should actively participate in the fight against nuclear armament. The short and long-term radiation effects on man and ecology are presented based on the Hiroshima and Nagasaki experiences. The danger of human error within this framework is emphasised and it is suggested that it is the medical profession's duty to point out how the effect of stress and boredom can lead to a nuclear catastrophe. Medical expertise may also help in the identification of unstable personalities among those who have access to nuclear weapons and in the understanding of the psycology of international conflicts and the psychopathology of those leaders who would use nuclear war as an instrument of national policy. Finally the effects of the nuclear war threat on children and teenagers are considered.

  6. Medical aspects of nuclear armament

    International Nuclear Information System (INIS)

    The authors highlight a few medical, biological and psycological aspects of the use of nuclear weapons, drawing attention to their viewpoint that doctors should actively participate in the fight against nuclear armament. The short and long-term radiation effects on man and ecology are presented based on the Hiroshima and Nagasaki experiences. The danger of human error within this framework is emphasised and it is suggested that it is the medical profession's duty to point out how the effect of stress and boredom can lead to a nuclear catastrophe. Medical expertise may also help in the identification of unstable personalities among those who have access to nuclear weapons and in the understanding of the psycology of international conflicts and the psychopathology of those leaders who would use nuclear war as an instrument of national policy. Finally the effects of the nuclear war threat on children and teenagers are considered. (C.F.)

  7. Carbohydrates

    Science.gov (United States)

    ... girls Eating healthy at restaurants Special food issues Vegetarian eating Eating for strong bones Quiz: Food Facts Links to more information girlshealth glossary girlshealth.gov home http://www.girlshealth.gov/ Home Nutrition Nutrition basics Carbohydrates Carbohydrates Carbohydrates (say: kar-boh- ...

  8. Current medical aspects of pantethine.

    Science.gov (United States)

    Horváth, Zoltán; Vécsei, László

    2009-07-30

    Pantethine, the stable disulfide form of pantetheine, is the major precursor of coenzyme A, which plays a central role in the metabolism of lipids and carbohydrates. Coenzyme A is a cofactor in over 70 enzymatic pathways, including fatty acid oxidation, carbohydrate metabolism, pyruvate degradation, amino acid catabolism, haem synthesis, acetylcholine synthesis, phase II detoxification, acetylation, etc. Pantethine has beneficial effects in vascular disease, it able to decrease the hyperlipidaemia, moderate the platelet function and prevent the lipid-peroxidation. Moreover its neuro-endocrinological regulating role, its good influence on cataract and cystinosis are also proved. This molecule is a well-tolerated therapeutic agent; the frequency of its side-effect is very low and mild. Based on these preclinical and clinical data, it could be recommended using this compound as adjuvant therapy. PMID:19685700

  9. Carbohydrates

    Science.gov (United States)

    Abumrad NA, Nassi F, Marcus A. Digestion and absorption of dietary fat, carbohydrate, and protein. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger & Fordtran's Gastrointestinal and Liver Disease. 10th ed. ...

  10. Carbohydrates

    Science.gov (United States)

    ... is fine because they contain important vitamins and minerals. But your body rapidly digests the starch in white potatoes. This can raise your blood glucose level. Healthy carbohydrates include: Natural sugars in fruits, vegetables, milk, and milk products Dietary fiber Starches in whole- ...

  11. Some medical aspects of radionuclide intakes

    International Nuclear Information System (INIS)

    In the field of medicine, particularly industrial medicine, the radiation aspect of the practice probably takes about 1/10 of 1% of our time. All the health physicist's tools of principles of internal dosimetry, lung models, mathematics, chemistry, etc. have little meaning until applied to an individual who has had an intake. This article discusses some of the medical aspects of internal dosimetry

  12. Some medical aspects of radionuclide intakes

    Energy Technology Data Exchange (ETDEWEB)

    Poda, G A

    1983-01-01

    In the field of medicine, particularly industrial medicine, the radiation aspect of the practice probably takes about 1/10 of 1% of our time. All the health physicist's tools of principles of internal dosimetry, lung models, mathematics, chemistry, etc. have little meaning until applied to an individual who has had an intake. This article discusses some of the medical aspects of internal dosimetry.

  13. Medical aspects of the Chernobyl accident

    International Nuclear Information System (INIS)

    From 11 to 13 May 1988, the All-Union Scientific Centre of Radiation Medicine convened a Conference on Medical Aspects of the Chernobyl Accident in Kiev. This was the first conference on this subject with international participation held in the Soviet Union. There were 310 specialists representing Soviet scientific establishments and over 60 experts from 23 other countries and international organizations participated in the Conference. Participants at the Conference discussed medical aspects of accident mitigation, including therapeutic, psychological, demographic, epidemiological and dosimetric problems. These proceedings include 29 reports presented by Soviet scientists during the four sessions as well as summaries of discussions and opening addresses. Refs, figs and tabs

  14. Special radiation protection aspects of medical accelerators

    CERN Document Server

    Silari, Marco

    2001-01-01

    Radiation protection aspects relevant to medical accelerators are discussed. An overview is first given of general safety requirements. Next. shielding and labyrinth design are discussed in some detail for the various types of accelerators, devoting more attention to hadron machines as they are far less conventional than electron linear accelerators. Some specific aspects related to patient protection are also addressed. Finally, induced radioactivity in accelerator components and shielding walls is briefly discussed. Three classes of machines are considered: (1) medical electron linacs for 'conventional' radiation therapy. (2) low energy cyclotrons for production of radionuclides mainly for medical diagnostics and (3) medium energy cyclotrons and synchrotrons for advanced radiation therapy with protons or light ion beams (hadron therapy). (51 refs).

  15. [Three aspects of the medical ethos].

    Science.gov (United States)

    Saraga, Michael; Marion-Veyron, Régis; Stiefel, Friedrich; Bourquin, Céline

    2016-02-10

    For many years, a major focus of interest has been the patient, in the context of a constantly changing society and increasingly complex medical practices. We propose to shift this focus on the physician, who is entangled in a similar, but less evident way. In these three articles, we explore, in succession, the lived experience of the contemporary physician, the ethos which brings together the medical community, and the education of the future physician, using research projects currently under way within the Service of Liaison Psychiatry at Lausanne University Hospital. Here, we describe three aspects of the medical ethos shaping medicine and the physicians: pragmatism, scientific rationality, and the individualistic embodiment of clinical practice. PMID:27039440

  16. [Legal aspects of networking of medical activities].

    Science.gov (United States)

    Preissler, Reinhold

    2005-04-01

    Medical networks lack a legal definition. From the viewpoint of social law, this term means a form of organization of joint-service providers in a non-specified composition for the undertaking of medical care activities; from the point of view of occupational law, this consists of a loose form of joint practice. Such medical network can conclude treatment contracts with the patients and exchange patients' medical records. A practice network can take over services as contract partner of hospitals or other institutions, in the interest of improved competition chances within the integrated care system. The joining of a third partner is basically left open by the MBO, however according to SGB V this is possible only after approval by all contract partners. In advance of a planned medical care center, is it recommended to found a physician network as starting model. Before single practices fuse into a single enterprise, management-, tax-, legal-, as well as psychological aspects must be considered. PMID:15957655

  17. SAFETY ASPECTS OF THE WATER TREATMENT SYSTEMS FOR MEDICAL UTILIZATION

    OpenAIRE

    Endre Ianosi

    2012-01-01

    To make sustainable the human life, in normal or specific medical situations, it is necessary to have adequate water resources. In medical utilization's of the water (dialysis, perfusable or liquid medication) some special water treatment systems and methods are necessary. These water treatment systems must accomplish some safety requirements. The safety of the patients relied to water treatment systems in medical utilization and the risk's identification are important aspects in this type of...

  18. [Medical professionalism: historical and religious aspects].

    Science.gov (United States)

    Rodríguez P, José Adolfo

    2006-03-01

    The essence of the medical profession resides in the medical act, whereupon a sick human being meets another with the power to heal him or her. The source of this power has evolved from the divinity itself through magic to science or acquired knowledge. This power implies acknowledgement of values that are inherent to the profession as well as responsibility toward one's own conscience and toward society, elements considered constitutive of what we now call professionalism. From antiquity these principles have evolved into behavioral codes containing variable components according to the different ages and cultures, but also permenent core values such as respect for life, altruism, and honesty, among others. Scientific and technological advances have magnified medical power but at the same time they have required that the philosophical and ethical principles that ought to inform professional practice be made explicit. This happens at a time when certitudes are questioned or abandoned, relativism and secularism pervade culture, and traditional medical values are challenged. Therefore, consensus attainment appears for some as the only legitimation of the ethics of professional medical acts, while for others the ancestral principles and values of medicine have permanent validity as objective goods based on the dignity of the human person. PMID:16676114

  19. Ethical aspect in medical radiation use

    International Nuclear Information System (INIS)

    Medical radiation uses hold a specific position in radiation protection. Patients are purposely exposed to radiation while usually radiation exposure should be avoided. The radiation doses are (at least in principle) planned the risks may be estimated (again in principle). The hazards are justified by the medical benefit. Otherwise irradiation is a violation of physical integrity (article 2 Grundgesetz) that can be prosecuted. For patients no dose limits exist, the responsible physician decides on the real exposures. Justification and optimization are of predominant importance. The decision on the radiological measure, the applied technology is an ethically motivated decision besides the everyday routine.

  20. [Aspects of communication regarding medical malpractice suits].

    Science.gov (United States)

    Pilling, János; Erdélyi, Kamilla

    2016-04-24

    Due to problems experienced in health care, there is an increased amount of malpractice suits nowadays. Nevertheless, some physicians are more likely to be sued, or more frequently sued, than others. Numerous studies indicate that this phenomenon fundamentally results from a lack of interpersonal and communication skills on the part of the sued doctor, namely, deficiencies in questioning the patient, listening, conveying information, etc. Communication is of pivotal importance in patient care vis-à-vis medical errors as well. The majority of physicians aim to conceal the error, albeit this may lead to further deterioration of the patient's condition. In institutions where open communication regarding errors was introduced within the medical team and toward the patient and their family alike, the number of malpractice suits decreased. It is crucial to establish a means of support for doctors, and to promote communication trainings, as well as a supportive legal environment. PMID:27084438

  1. Worker radiological protection: occupational medical aspects

    International Nuclear Information System (INIS)

    Radiation exposures experienced by workers are widely explained. The first evidences of biological effects, the implications for human health and the radiological protection have been covered. The conceptual structure that covers the radiological protection and adequate protection without limiting benefits, the scientific basis of radiology, the benefits and risks of the radiological protection are specified. The effective per capita doses are exposed in medical uses both for Latin America and for other regions in the average radiology, dental radiology, nuclear medicine and radiotherapy. The manners of occupational exposures in the medicine are presented. Industrial uses have also its average effective dose in the industrial irradiation, industrial radiography and radioisotopes production. Within the natural radiation the natural sources can significantly contribute to occupational exposure and have their average effective dose. Occupational medical surveillance to be taken into industrial sites is detailed. In addition, the plan of international action for the solution of dilemmas of occupational exposures is mentioned and the different dilemmas of radioactive exposure are showed. The external irradiation, the acute diseases by radiations, the cutaneous syndrome of the chronic radiation, the radioactive contamination, the internal radioactive contamination, the combined lesion and accidental exposures are also treated

  2. Radiological accident 'The Citadel' medical aspects

    International Nuclear Information System (INIS)

    The work exposes the medical actions carried out in the mitigation of the consequences of the accident and its main results. In a facility of storage of radioactive waste in Caracas, Venezuela, it was happened a radiological accident. This event caused radioactive contamination of the environment, as well as the irradiation and radioactive contamination of at least 10 people involved in the fact, in its majority children. Cuban institutions participated in response to the accident. Among the decisions adopted by the team of combined work Cuban-Venezuelan, we find the one of transferring affected people to Cuba, for their dosimetric and medical evaluation. Being designed a work strategy to develop the investigations to people affected by the radiological accident, in correspondence with the circumstances, magnitude and consequences of the accident. The obtained main results are: 100% presented affectations in its health, not associate directly to the accident, although the accident influenced in its psychological state. In 3 of studied people they were detected radioactive contamination with Cesium -137 with dose among 2.01 X 10-4 Sv up to 2.78 X 10-4 Sv. This accident demonstrated the necessity to have technical capacities to face these events and the importance of the international solidarity. (author)

  3. Medical physics aspects of ophthalmic brachytherapy

    International Nuclear Information System (INIS)

    Intraocular melanoma is the most common primary malignancy of the eye. Radiation therapy using ophthalmic plaque has proved successful in the management of various ocular lesions. Although a few centres were using 90Sr/90Y plaques for shallow turtlours some years ago, eye plaque therapy was not a common practice in India. A revived interest in the use of eye plaque therapy and very high cost of imported sources has led to the development and production of 125I seed sources by the Radiopharmaceuticals Division, BARC. This report presents a brief description on the clinical, dosimetry and radiation safety aspects of 90Sr/90Y and 106Ru/106Rh beta ray and 125I gamma ray eye plaque applicators. This report has been divided in five Sections. Section I presents general introduction of ophthalmic brachytherapy including the structure of a human eye, types of ophthalmic plaques and characteristics of radioisotopes commonly used in such applications. A brief review of sources, applicators and dosimetry of 90Sr/90Y and 106Ru/106Rh beta and 125I gamma ophthalmic plaques are given in Section II and Section III, respectively. Section IV contains the single seed dosimetry data of BARC OcuProsta 125I seed as well as dosimetry data of typical eye plaques loaded with BARC OcuProsta 125I seed. Quality assurance and radiation safety aspects of these eye applicators are described in Section V. A proforma of the application required to be filled in by the user institution for obtaining regulatory consent to start eye plaque therapy has also been appended to this report. (author)

  4. Epilepsy in young adulthood : medical, psychosocial and functional aspects

    OpenAIRE

    Gauffin, Helena

    2012-01-01

    The aim of this thesis was to describe the medical, cognitive and psychosocial consequences of epilepsy in young adulthood. Four studies were carried out with this patient group. The first two papers were based on a follow-up study regarding young adults with epilepsy that investigated medical and psychosocial aspects and compared the present results with those five years earlier. We then conducted focus group interviews with young adults with epilepsy and subjective cognitive decline to asse...

  5. Chemical radiation protection of certain aspects of carbohydrate metabolism in irradiated rats

    International Nuclear Information System (INIS)

    Because of the practical importance of certain compounds that exhibit protective character against lethal effects of ionizing radiation, repeated investigations have been carried out to evaluate the radioprotective efficiency of such compounds and to study the mechanism through which they manifest their radioprotective effects. The present study is an attempt to investigate the possible role which the heterocyclic nitrogenous compounds (glyoxaline and benzoglyoxaline) can play as radioprotectors against radiation-induced changes in carbohydrate metabolism. The parameters studied were, survival rate, bloodglucose level, gamma insulin level and liver glycogen concentration

  6. Social accountability of medical education: aspects on global accreditation.

    Science.gov (United States)

    Lindgren, Stefan; Karle, Hans

    2011-01-01

    Medical doctors constitute a profession which embraces trust from and accountability to society. This responsibility extends to all medical educational institutions. Social accountability of medical education means a willingness and ability to adjust to the needs of patients and health care systems both nationally and globally. But it also implies a responsibility to contribute to the development of medicine and society through fostering competence for research and improvement. Accreditation is a process by which a statutory body evaluates and recognises an educational institution and/or its programme with respect to meeting approved criteria. It is a means for quality assurance, but also a strong power to reinforce the need for improvement and reforms. It must be performed through internationally recognised and transparent standards and should foremost promote quality development. The social accountability of medical education must be included in all accreditation processes at all levels. The global standards programme by World Federation for Medical Education (WFME) provides tools for national or regional accreditation but also guidance for reforms and quality improvement. The standards are used worldwide and have been adopted to local needs in most parts of the world. They are framed to specify attainment at two levels: basic standards or minimum requirements and standards for quality development. The concept of social accountability is embedded in all parts of the WFME standards documents. In 2011, a revision of the standards for undergraduate education has been instituted. Strengthening of aspects on social accountability of medical education will be a particular concern. PMID:21774655

  7. MONITORING THE SAFETY ASPECTS OF OVER THE COUNTER MEDICATIONS

    Directory of Open Access Journals (Sweden)

    M.Z. Subin

    2012-03-01

    Full Text Available OTC medication is short for over the counter drugs. These medicines have become popular as they are available without a prescription from the doctor. These are medicaments that are usually used to relieve pain and to treat various symptoms of cold. Most of the over-the-counter users believe that these medications are safer and are devoid of unwanted side effects. But their use may become fatal sometimes when they are administered without knowing the prescription pattern, that is, when they are used without properly reading the directions on the label. More over, the consumers are not aware of the safety of these drugs and its frequent use may result in various adverse effects. It is the part of the patient to read out the label packaging instructions for OTC medications to know how much one should take, the possible side effects that may encounter and the various conditions that can result in poor choice of the drug. Various other aspects such as the recommended dose, contraindications and drug interactions should be considered before taking OTC drugs. Pharmacists and drug companies will have an increasingly important role in giving information and advice to the patients. This review highlights the safety aspects of OTC drugs. It summarizes the safety measures that should be taken into consideration when used among different age groups.

  8. Kinesitherapy: One of the most important aspects of medical rehabilitation

    Directory of Open Access Journals (Sweden)

    Savić Kosta

    2005-01-01

    Full Text Available Introduction Kinesitherapy, as a part of physical therapy, represents one of the most important aspects of medical rehabilitation. It involves movement of various parts of the body, or of the whole body, using exercises in order to maintain, establish, develop and change functions of the locomotor apparatus and organs of locomotion. Aim The aim of kinesitherapy is to use all potentials of the treated patients, to achieve optimal recovery of the damaged function of locomotion. Classification Kinesitherapy includes active and passive exercises. Active exercises are divided into: active exercises with assistance, without assistance and active exercises with resistance. Indications and contraindications Kinesitherapy is applied in almost all medical branches in numerous pathological conditions, as well as a method of prevention. Practically, there are no absolute contraindications, and relative are extremely rare.

  9. Medical and organizational aspects related to the Goiania accident

    International Nuclear Information System (INIS)

    On 13 September 1978, a severe radiation accident occurred in the city of Goiana in central Brazil. Approximately 250 people were directly affected by the radiation, receiving slight to very several external, partial or whole body irradiation, and presenting internal and external contamination. Fourteen patients developed some degree of marrow failure, eight developed the clinical signs and symptoms of acute radiation syndrome (ARS), and four eventually died of ARS complications. Twenty-eight people showed acute localized radiation injuries ranging from first to third degree. The circumstances of the event are described, the first-aid measures taken on the site, and the medical structure organized to triage and treat the casualties. Aspects relating to hospital contamination control, radiation protection and decontamination procedures are also discussed. (author) 10 refs.; 5 tabs

  10. Skylab mission report, second visit. [postflight analysis of engineering, experimentation, and medical aspects

    Science.gov (United States)

    1974-01-01

    An evaluation is presented of the operational and engineering aspects of the second Skylab flight. Other areas described include: the performance of experimental hardware; the crew's evaluation of the flight; medical aspects; and hardware anomalies.

  11. On the evaluation of the safety aspects of nanomaterials in medical devices – a regulatory perspective

    OpenAIRE

    Wu, Eva; Chan, Christopher; Li, Albert

    2013-01-01

    Nanotechnology is widely used in many aspects of the design and manufacture of medical devices. To date, many of these new medical devices, referred to as nano medical devices, have been submitted to health authorities for premarket regulatory review. There are ongoing discussions between medical device manufacturers and regulatory authorities regarding the standards and methods required for the evaluation process. Taking into consideration aspects including nano-toxicology and biocompatibili...

  12. Medical aspects of quality assurance in the United States

    International Nuclear Information System (INIS)

    Three powerful national programs have been developed, and their acceptance and utilization in the United States have been accelerated by the recent development of managed competition. The first program was a model quality assurance program for day to day use in an individual radiation oncology facility. In addition to maintaining the physical aspects of the department, the medical side includes indicator items in patient evaluation and treatment and other measures that are periodically monitored. The entire process is comprehensive and is accepted by the Joint Commission on Hospital Accreditation as being satisfactory evidence of ongoing quality assurance and quality improvement. The second program was the development of a set of standards for radiation oncology in the United States. These standards were developed in the past and have recently been expanded into a more comprehensive document that describes the appropriate performance by this specialty. The third program was a Practice Accreditation program. The Practice Accreditation program is an on-site review of structure and processes of patient care by a radiation oncologist and data manager. This intense on-site review generated data that is then compared to similar facilities and to national averages to judge the adequacy of patient management in the facility. We have observed recently that various managed care programs require this practice accreditation before their patients can be treated in contracting facilities. Lastly, the Council of the American College of Radiology has made some extremely positive statements in support of improving radiation oncology practice, and the positive effects of these council resolutions can be clearly shown on the practice

  13. Social accountability of medical education: Aspects on global accreditation.

    OpenAIRE

    Lindgren, Stefan; Karle, Hans

    2011-01-01

    Medical doctors constitute a profession which embraces trust from and accountability to society. This responsibility extends to all medical educational institutions. Social accountability of medical education means a willingness and ability to adjust to the needs of patients and health care systems both nationally and globally. But it also implies a responsibility to contribute to the development of medicine and society through fostering competence for research and improvement. Accreditation ...

  14. Regulations and legal aspects in management of medical waste

    OpenAIRE

    Sikovska, Biljana; Dimova, Cena; Sumanov, Gorgi; Apostoloski, Pavle

    2015-01-01

    Medical waste, according to the law of waste management is waste generated in medical and health institutions (dispensaries, hospitals, polyclinics and outpatient clinics, dental clinics, veterinary stations etc.), originated as a product of used items and materials during diagnosis, convalescence, treatment and prevention in humans and animals. Medical waste is a risk to those who produce, package, store, transport, treat and perform disposition. The possibility of infection of some disea...

  15. Counting carbohydrates

    Science.gov (United States)

    Carb counting; Carbohydrate-controlled diet; Diabetic diet; Diabetes-counting carbohydrates ... goal is not to limit carbohydrates in the diet completely, but to make ... with diabetes can better control their blood sugar if they ...

  16. [Forensic-medical aspects of injuries inflicted by nonlethal arms].

    Science.gov (United States)

    Babakhanian, A R; Babakhanian, R B; Isakov, V D

    2005-01-01

    Special literature (surgical, forensic-medical and criminalistic) is reviewed on classification, mechanisms of a harmful action and characteristics of injuries inflicted by non-lethal arms. Some details of such arms construction and damaging action are given. PMID:16130323

  17. MONITORING THE SAFETY ASPECTS OF OVER THE COUNTER MEDICATIONS

    OpenAIRE

    M.Z. Subin; V.Vidya; O.A. Halima; G. Geethu; N. Devika

    2012-01-01

    OTC medication is short for over the counter drugs. These medicines have become popular as they are available without a prescription from the doctor. These are medicaments that are usually used to relieve pain and to treat various symptoms of cold. Most of the over-the-counter users believe that these medications are safer and are devoid of unwanted side effects. But their use may become fatal sometimes when they are administered without knowing the prescription pattern, that is, when they ar...

  18. Physiological and medical aspects of strenuous mass sport events.

    Science.gov (United States)

    Vuori, I

    1982-01-01

    This review summarizes the main features to be considered previous to and during the performance of strenuous, prolonged mass sport events. At the present time the best predictors of one's ability to endure the effort are probably not physiological tests but detailed information of one's health status and exercise habits in relation to the type, duration, and intensity of the event. The preparation for high-intensity events lasting 1 1/2 hours or more should include filling of the glycogen stores of the most taxed muscles by proper supercompensation techniques. During and even immediately prior to prolonged activities, largely irrespectively of their intensity, it is advisable to ingest small amounts of easily absorbable carbohydrate, best as fluid, latest after 1 1/2 hours of exercise, and every 20-30 min thereafter. Fluid loss should be kept in minimum by drinking 150-200 ml at a time 3 to 4 times per hour. This is of ultimate importance in warm and hot weather. In cold especially middle-aged and older persons should pay special attention to avoid excessive intensity of effort during the first 15 min of exercise, and to protect the most cold sensitive parts of the body, like head and neck, in order to avoid reflex increase of circulatory stress. Serious health risks of mass sport events have been shown to be small, when factors causing excessive acute, circulatory load are avoided. Therefore, exercise during or shortly after acute or febrile illness, start of exercise without sufficient warm-up especially in cold, sudden or maximal bursts of activity, exercise loaded with strong emotions, exercise after heavy meal or alcohol intake, and smoking during exercise should be avoided. PMID:7149623

  19. [Intercultural aspects of medical care for undocumented migrants].

    Science.gov (United States)

    Cerda-Hegerl, Patricia

    2008-01-01

    In view of the cultural diversity in German society today, the time has long since come when medical care must adjust to its new clientele. This article provides an overview for doctors, medical personnel and psychologists of approaches, backgrounds and networks of migration to Germany, in particular over the little known undocumented migration. This migration has steadily increased in recent years. The author deals with the circumstances which create psychological problems for migrants and what happens when migrants living in this shadow world fall ill. In addition, the article offers an agenda for interculturally competent action in caring for documented and undocumented migrants. Dimensions of cultural differences such as collectivism versus individualism (most of the countries of origin of these migrants in Germany with or without documents are collectivistic) are explained along with differences in styles of communication. The following styles with their impact in actual practice are analyzed: indirect versus direct communication; emotional control versus expressiveness; functionalism versus relationship orientation. PMID:18421653

  20. [Psychological aspects of public activity of a forensic medical examiner].

    Science.gov (United States)

    Bashkireva, E A; Buromskiĭ, I V

    2009-01-01

    In the recent years, professional activity of forensic medical examiners has been gaining publicity which necessitates knowledge of individual psychologic personality traits, the ability to effectively communicate, and high vocational culture on the part of each specialist. The specific character of professional contacts of a forensic medical expert is self-evident taking into consideration that he (she) has to deal with a great variety of persons including law enforcement officials, law breakers and criminal offence victims, men and women, young and aged people, representatives of different social groups, subjects in a specific emotional state, etc. In order to organize efficacious cooperation with all these individuals, the expert must develop high communicative competence, possess knowledge of psychology of communication, abilities and skills necessary for the establishment and maintenance of professional and business contacts. PMID:19371013

  1. Legal aspects of medical confidentiality in the occupational setting.

    Science.gov (United States)

    Annas, G J

    1976-08-01

    The law of confidentiality of medical information in the occupational setting is undeveloped and subject to change. Nevertheless, when a physician-patient relationship is established, all of the traditional trappings, including the duty to maintain confidences, go along with it. In other settings, such as preemployment physicals, examinees implicitly consent for their "fitness' for the job to be disclosed, but do not assume that specific findings will be disclosed without their informed and written consent. To promote physician automony and worker confidence in the occupational physician, an explicit policy of confidentiality should be developed and agreed to by both management and workers. This policy should spell out the conditions under which specific information will be made available to the employer and should guarantee the confidentiality of all other medical information. Workers should also be given routine access to their medical files, and offered the chance to refute and have amended information in them that they can demonstrate is inaccurate. In short, workers in the occupational setting should, in general, be treated like private patients. Such a policy will satisfy both the law and the ethical standards of physicians, and will promote worker trust in the occupational physician. PMID:956937

  2. Medical and legal aspects of teleradiology in Germany

    International Nuclear Information System (INIS)

    In teleradiology, imaging data are transferred over a distance. This service is provided for the purpose of consulting or teleradiological reading in the narrower sense. Once a justification has been proposed in the latter, the examination is performed under the responsibility of a radiologist who is not present on site. The need for teleradiology services often derives from sparsely populated areas, a shortage of doctors, or the need for cost-efficient provision of radiological examinations. The providers and recipients of teleradiology services enter into an agreement specifying conditions for data transfer. The German ionizing radiation (medical exposure) regulations demand that the teleradiologist holds radiation protection qualifications and is able to reach the examination site within 45 - 60 minutes. In Germany, teleradiology services are still limited to nights, weekends, and vacations, although the German regulations allow an expansion under certain circumstances. Efforts to fundamentally change radiology in favor of teleradiology are putting the status of a radiological medical act as well as current teaching models at risk, thereby indirectly sustaining physician shortage. Transnational teleradiology services offer the possibility of cost reduction, taking advantage of out-of-hour reading and wage fluctuation. At the same time, such services are associated with deficits in quality and availability of personnel as well as the quality of medical services. In the long-term teleradiology concepts will fundamentally change radiology. Smaller radiology units will concentrate on daily business and fast reporting. Larger units also providing academic teaching can use teleradiology networks to offer specialized readings. (orig.)

  3. 76 FR 37154 - Covidien, Formerly Aspect Medical, R & MS Division, Including On-Site Leased Workers From Kelly...

    Science.gov (United States)

    2011-06-24

    ... Employment and Training Administration Covidien, Formerly Aspect Medical, R & MS Division, Including On- Site..., 2011, applicable to workers of Covidien, formerly Aspect Medical, R & MS Division, including on-site...-site at the Norwood, Massachusetts location of Covidien, formerly Aspect Medical, R & MS Division....

  4. Medical aspects of the Battle of Waterloo: the battle.

    Science.gov (United States)

    Crumplin, Mick

    2015-06-01

    The Duke of Wellington's polyglot army assembled for the Waterloo campaign was hastily aggregated and the Army Medical Department was somewhat short of staff and not entirely of the calibre of the department serving latterly in the Peninsular campaigns. The casualty rates during the battles of this campaign were high and the regimental and hospital staff struggled with the large number of casualties. Lack of stretcher bearers and transport were significant problems, which were compounded by the high density of the casualties. Three quarters of the surviving wounded rejoined their units. PMID:25525203

  5. [In vitro fertilization and intracytoplasmic sperm injection: current medical aspects].

    Science.gov (United States)

    Kentenich, H; Sibold, C; Tandler-Schneider, A

    2013-12-01

    Since the delivery of the first baby conceived via in vitro fertilization (IVF) in 1978, IVF has become a standard procedure in sterility treatment. In Germany, 78,000 IVF/intracytoplasmic sperm injection (ICSI) cycles are performed annually with a delivery rate per embryo transfer of about 20 %. The cumulative delivery rate after three trials is more than 50 %. The main medical problems are the high rates of multiple pregnancies of more than 20 %, which carry an increased risk for mothers (preeclampsia) and children (preterm delivery, lung immaturity, brain problems). Also singleton babies after IVF are more often too small (small for gestational age, SGA) and delivered preterm. As a result, proper counselling is necessary. New laboratory methods have increased the success rate. Cryopreservation techniques such as vitrification are standard for freezing oocytes, pronuclear-stage oocytes and embryos if they are not needed during the current treatment cycle. Continuous observation of embryos by time-lapse imaging helps to identify the best embryos for transfer. The current legislation in the German embryo protection act (Embryonenschutzgesetz) is the main problem. It is unclear how many fertilized oocytes can be cultured to achieve a transfer of one to three embryos. The prohibition of oocyte donation and surrogacy are not comprehensible from a medical, psychological, and ethical point of view. Reimbursement of publicly insured patients is restricted in comparison with other European countries. Married couples receive half of the payment for three IVF/ICSI cycles; non-married couples receive no payment at all. PMID:24337127

  6. Ethical aspects of using medical social media in healthcare applications.

    Science.gov (United States)

    Denecke, Kerstin

    2014-01-01

    The advances in internet and mobile technologies and their increased use in healthcare led to the development of a new research field: health web science. Many research questions are addressed in that field, starting from analysing social-media data, to recruiting participants for clinical studies and monitoring the public health status. The information provided through this channel is unique in a sense that there is no other written source of experiences from patients and health carers. The increased usage and analysis of health web data poses questions on privacy, and ethics. Through a literature review, the current awareness on ethical issues in the context of public health monitoring and research using medical social media data is determined. Further, considerations on the topic were collected from members of the IMIA Social Media Working group. PMID:24825685

  7. Regulatory aspects of the radiation safety in the medical practice

    International Nuclear Information System (INIS)

    The biological effects of the ionizing radiations can be stochastic and non-stochastic. These latter show a dose-effect relation with defined level of threshold dose. The stochastic effects lack of the threshold dose and the possibility of their occurrence is proportional to the received dose. The radiation protection objetive is to avoid the occurrence of the non-stochastic effects and to limit the probability of the stochastic effects, based on three principles: justification, dose limitation and optimization. All use of radiation source must be justified by real benefits; nevertheless, the risks are not limited, so dose limits to reduce them must be adopted. In the medical practice, both worker and patient expositions are considered. In case of patients, the concept of dose limits is not applied, but justification and optimization, are used. The Authorities of Radiological Inspection are: the National Atomic Energy Comission for the use of radioactive sources, and the Secretary of Health for X-ray equipments. Both organisms work in coordination since 1967 (M.E.L.)

  8. Animal poisoning - veterinary-medical and criminal-legal aspects

    Directory of Open Access Journals (Sweden)

    Aleksić Jelena

    2014-01-01

    Full Text Available Apart from approved or planned poisoning with agricultural purpose, an increase in the number of cases of intentional animal poisoning (primarily referring to cats and dogs has been detected in Serbia, and it is suspected that their number is significantly larger than the one shown by the official statistics data. Under the conditions prescribed by the Criminal Code of the Republic of Serbia, such activities may represent the crime of killing and torture of animals, but also the crime of causing a general danger. It would be impossible to conduct the procedure of discovering and proving these criminal offences and the responsibility of their perpetrators without findings and opinion of forensic veterinary-medicine experts. They play an important role when it comes to site inspection, crime scene processing, collecting the samples from the crime scene, processing of samples and autopsy and exhumation of a potentially poisoned animal body. Just like other evidence in criminal procedure, findings and opinion of experts of veterinary medicine are estimated in accordance with the principle of free assessment of evidence. However, due to the specificity of such cases of killing and torture of animals, their impact on court’s decision on the existence of criminal offence and perpetrator’s liability is crucial. In this paper, the authors discuss the scope of animal poisoning in Serbia, particularly in Belgrade, analyze possible criminal - legal consequences of these illegal activities and point out to a significant role that experts of veterinary medical profession have in discovering and proving such cases and the liability of their perpetrators.

  9. Course on medical aspects of nuclear and radiation accidents. Proceedings

    International Nuclear Information System (INIS)

    The Tchernobyl event deflected the attention from other potential hazards related to ionizing radiation as can result from misfunction or misuse of radioactive sources widely applied in human medicine or in industry. It was only after the Goiania accident in Brazil that these radiation sources retrieved the attention they deserve. Around the world, great efforts have been undertaken by the producers and users of these sources, supported by scientific investigations and by legislative backing, to minimize to the greatest extent possible any risk to public health. Nevertheless, accidents involving serious overexposures of individuals cannot be excluded entirely for the future. It is therefore a matter of professional responsibility to carefully evaluate the experiences gathered in the wake of radiation accidents and proliferate this knowledge to those professionals-health physicists, decontamination specialists, medical and paramedical staff - that might be confronted with the consequences of an accident and from whose expertise and proper handling human lifes might depend. It was with this aim that the Atomic Energy Authority and the International Bureau of the Forschungszentrum Juelich undertook to organize a joint training course within the German-Egyptian governmental agreement on bilateral cooperation in scientific research and technological development signed on 11.4.1979. Selected experts from both sides convened and presented both compended text book knowledge as well as own recent scientific data reflecting the state of the art. This material was selected and prepared in order to fit the needs of the invited 25 Egyptian physicians and paramedical course participants who where to be given guidelines on how to react to radiation overexposure incidents. (orig.)

  10. Carbohydrate Analysis

    Science.gov (United States)

    Bemiller, James N.

    Carbohydrates are important in foods as a major source of energy, to impart crucial textural properties, and as dietary fiber which influences physiological processes. Digestible carbohydrates, which are converted into monosaccharides, which are absorbed, provide metabolic energy. Worldwide, carbohydrates account for more than 70% of the caloric value of the human diet. It is recommended that all persons should limit calories from fat (the other significant source) to not more than 30% and that most of the carbohydrate calories should come from starch. Nondigestible polysaccharides (all those other than starch) comprise the major portion of dietary fiber (Sect. 10.5). Carbohydrates also contribute other attributes, including bulk, body, viscosity, stability to emulsions and foams, water-holding capacity, freeze-thaw stability, browning, flavors, aromas, and a range of desirable textures (from crispness to smooth, soft gels). They also provide satiety. Basic carbohydrate structures, chemistry, and terminology can be found in references (1, 2).

  11. Bioorganic chemistry research in the Institute of Organic Chemistry and Biochemistry - medical aspects

    Czech Academy of Sciences Publication Activity Database

    Holý, Antonín

    2004-01-01

    Roč. 10, Supplement (2004), s. 107. ISSN 1075-2617. [ International /3./ and European Peptide Symposium /28./. 05.09.2004-10.09.2004, Praha] Institutional research plan: CEZ:AV0Z4055905 Keywords : bioorganic chemistry research * medical aspects Subject RIV: CE - Biochemistry

  12. [Current aspects of war surgery. From the trauma center to precarious medical care].

    Science.gov (United States)

    Houdelette, P

    1997-01-01

    War, said Carl von Clausewitz, is a cameleon. In this century, each armed conflict has proved to be unique, particularly in its medical aspects, with its own features and teaching its won lessons. As recent events show, no conflict is a fact of the past. Medical care delivered to war casualties depend on the circumstances of the war, on the medical resources available, but also on the price that cultures or circumstances place on it. Everything separates these two paradigms; on the one hand the "precious" casualty of western armies whose medical support is organized in a concept (forward medical and surgical care, ultra-rapid medical evacuation) tailored to each case, and as close as possible to the medical care of a civilian trauma patient whose models remains the North-American ballistic wound managed in trauma centers; on the other hand, civilian victims, in large numbers, in poor and disorganized countries, often abandoned to their own fate or sorted by "epidemiological" triage, which guarantees a distribution, as efficient as possible, of limited medical care. In war, advanced medical care and precarious medicine may work side by side according to two logics which do not exclude one another and constantly improve. PMID:9297902

  13. Integration of gender-specific aspects into medical curricula - status quo und future perspectives

    Science.gov (United States)

    Pfleiderer, Bettina; Burghaus, Désirée; Bayer, Gudrun; Kindler-Röhrborn, Andrea; Heue, Matthias; Becker, Jan Carl

    2012-01-01

    The consideration of gender aspects in clinical routine is of high importance towards an individualized patient care and a starting point of diversity medicine. Gender-specific awareness is an indispensable basis for an optimized medical treatment. A current study at the medical faculties of Muenster and Duisburg-Essen University (Germany) revealed an insufficient knowledge among students and lecturers in this area. An interdisciplinary, international workshop took place in Muenster (Germany) in May 2012 on the topic how to integrate gender aspects into medical curricula in the future aiming at a better health care for both sexes in long term. This position paper summarizes the conclusions. It was suggested to teach gender-specific contents from the first semester comprehensively – using standardized definitions and a gender-neutral language, since it is crucial not to increase the students’ workload any further. The key to success is to implement gender aspects by using meaningful examples on a regular basis – ideally in a longitudinal manner. The content of teaching should be selected by the lecturers and full professors and be considered within students´ exams. To reach these goals, an absolute support of the respective medical faculties as well as the integration of these gender-specific learning objectives into the national competence-based learning catalogue for medical education (NKLM) is obligatory. PMID:23255960

  14. Organizing multivalency in carbohydrate recognition.

    Science.gov (United States)

    Müller, Christian; Despras, Guillaume; Lindhorst, Thisbe K

    2016-06-01

    The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates. We are discussing primary, secondary and tertiary structural aspects including approaches to organize multivalency. PMID:27146554

  15. Patients' attitudes to medical and psychosocial aspects of care in fertility clinics

    DEFF Research Database (Denmark)

    Schmidt, L; Holstein, B E; Boivin, J;

    2003-01-01

    among infertile people. METHODS: We conducted an epidemiological study based on questionnaires among all new couples attending five fertility clinics with a response rate of 80.0% and a total of 2250 patients. RESULTS: The vast majority of both men and women considered a high level of medical...... services for both men and women was high infertility-related stress in the marital, personal and social domain. CONCLUSIONS: A supportive attitude from medical staff and the provision of both medical and psychosocial information and support should be integral aspects of medical care in fertility clinics....... Although only a minority of the participants perceived professional psychosocial services as important, they should be available for patients whose infertility causes them much strain, especially for patients whose marital relationship suffered much because of infertility....

  16. Development of an informative system on aspects of radiological protection in the medical practices

    International Nuclear Information System (INIS)

    Today in day is difficult to imagine the development of the medical practices in the diagnosis and treatment of diverse illnesses without the use of the ionizing radiations. In spite of the diffusion and application of these practices, the patients and the public in general don't have full conscience of like the procedures are carried out and the risks that these involve. For it diverse international and national organizations in the last years recommend to include in the programs of radiological protection, all the information that should be given to the patients and the one public that attend as users to the medical institutions to undergo to procedures that imply the use of the ionizing radiations. In Cuba a growing and quick tendency exists to the introduction of nuclear techniques for medical ends, however paradoxically the relative aspects to the communication to the patients and the public in general about the risks of the procedures to that they will be subjected and in consequence on the measures to minimize them is not adequate. Keeping in mind the above-mentioned, specialists of national centers linked to the control and consultant ship in the topics of radiological protection in the medical practices that use ionizing radiations, they worked in the country in the design of an information system that should contribute to elevate the population's culture before the mentioned aspects. The present work describes the structure of this system in function of the different medical attention levels of our national health system. Additionally it exposes the development of a package of varied informative and training tools among those that are folding, posters, guides, instructions, CD Show that its approach general and specific aspects of the uses and risks of medical practices in nuclear medicine, radiodiagnostic and radiotherapy directed so much to health professionals, patients as public in general. (Author)

  17. Perioperative stress in dogs : Different aspects of manifestation and characteristics with medetomidine and acepromazine preanaesthetic medication

    OpenAIRE

    VÀisÀnen, Misse

    2006-01-01

    The series of investigations presented in this thesis examined different aspects of the manifestation of perioperative stress in client-owned dogs and compared the influences of two preanaesthetic medications. Data were obtained from 43 overtly healthy dogs that underwent ovariohysterectomy following preanaesthetic administration of medetomidine and butorphanol (MED) or acepromazine and butorphanol (ACE) (Study 1) and from 96 dogs that were recovering from day-case soft-tissue operations at h...

  18. Aspects Regarding the Medical Data Processing - The Statistical Study of Malocclusions

    OpenAIRE

    Georgeta ZEGAN; Cristina Gena DASCALU

    2012-01-01

    An important aspect in the analysis of medical data is represented by their statistical processing, which gives useful directions in finding the diagnosis and the most adequate treatment, especially when the amount of statistical data is very large and extended in time. We give an example in this paper, by presenting a statistical evaluation on a consignment of patients who have addressed the Dental Ambulatory for Children (Iaşi) for orthodontic consulting over a period of 10 years (2000 – 20...

  19. Carbohydrate microarrays

    DEFF Research Database (Denmark)

    Park, Sungjin; Gildersleeve, Jeffrey C; Blixt, Klas Ola; Shin, Injae

    2012-01-01

    In the last decade, carbohydrate microarrays have been core technologies for analyzing carbohydrate-mediated recognition events in a high-throughput fashion. A number of methods have been exploited for immobilizing glycans on the solid surface in a microarray format. This microarray-based technol......In the last decade, carbohydrate microarrays have been core technologies for analyzing carbohydrate-mediated recognition events in a high-throughput fashion. A number of methods have been exploited for immobilizing glycans on the solid surface in a microarray format. This microarray......-based technology has been widely employed for rapid analysis of the glycan binding properties of lectins and antibodies, the quantitative measurements of glycan-protein interactions, detection of cells and pathogens, identification of disease-related anti-glycan antibodies for diagnosis, and fast assessment of...

  20. Consanguinity and endogamy in the Netherlands: demographic and medical genetic aspects.

    Science.gov (United States)

    Ten Kate, Leo P; Teeuw, Marieke E; Henneman, Lidewij; Cornel, Martina C

    2014-01-01

    This paper reviews what is currently known about the presence of consanguinity and endogamy in the Netherlands, in the past and today, and concludes with a discussion of medical genetic aspects. First geographic characteristics, the demographic history, the genetic make-up of the native population, legal aspects and the public opinion are reviewed. Then data on the prevalence of consanguinity in the native population are presented for marriages since 1840, followed by data on consanguineous marriages among immigrants from countries with a tradition of close-kin marriages. It is estimated that approximately 1% of at-risk consanguineous couples are referred to clinical genetic centres for prospective genetic counselling in the Netherlands. This picture will change dramatically if and when next-generation sequencing is introduced to identify couples at ≥ 25% risk prospectively. PMID:25060279

  1. Design and implementation of a radiotherapy programme: Clinical, medical physics, radiation protection and safety aspects

    International Nuclear Information System (INIS)

    It is widely acknowledged that the clinical aspects (diagnosis, decision, indication for treatment, follow-up) as well as the procedures related to the physical and technical aspects of patient treatment must be subjected to careful control and planning in order to ensure safe, high quality radiotherapy. Whilst it has long been recognized that the physical aspects of quality assurance in radiotherapy are vital to achieve and effective and safe treatment, it has been increasingly acknowledged only recently that a systematic approach is absolutely necessary to all steps within clinical and technical aspects of a radiotherapy programme as well. The need to establish general guidelines at the IAEA, taking into account clinical medical physics, radiation protection and safety considerations, for designing and implementing radiotherapy programmes in Member States has been identified through the Member States' increased interest in the efficient and safe application of radiation in health care. Several consultants and advisory group meetings were convened to prepare a report providing a basis for establishing a programme in radiotherapy. The present TECDOC is addressed to all professionals and administrators involved in the development, implementation and management of a radiotherapy programme in order to establish a common and consistent framework where all steps and procedures in radiotherapy are taken into account

  2. Medical aspects of human population and personnel protection in case of accident response

    International Nuclear Information System (INIS)

    Paper deals with the chronological description of the taken measures linked with medical aspects of safety assurance of the population and of the personnel at the elimination of the accident consequences. Attention is focused on the arrangement of the curative-and-prophylactic aid, on treatment of injured people. Irradiation levels for the population immediately after the accident. Time dose limits of the external and internal irradiation of the population of the contaminated territory, and of the personnel involved in the elimination activities are substantiated. Health of the population of the accident zone is estimated. 4 figs.; 2 tabs

  3. Understanding Carbohydrates

    Science.gov (United States)

    ... Low-calorie sweeteners are also called artificial sweeteners, sugar substitutes or non-nutritive sweeteners. They can be used to sweeten food and drinks for less calories and carbohydrate when they replace sugar. Sugar and Desserts With diabetes, it's important to ...

  4. Healthy carbohydrates

    Science.gov (United States)

    Functional foods include dietary fiber consisting of health-promoting carbohydrates. We have produced novel prebiotics from orange peel and observed that they extend the shelf life of probiotic bacteria in synbiotics. Some pectic-oligosaccharides and xyloglucan-oligosaccharides also have anti-adhesi...

  5. Health Care Professionals’ Knowledge and Attitudes About Sexually Transmitted Diseases and Legal Aspects of Medical Services

    Directory of Open Access Journals (Sweden)

    Akpak Yaşam Kemal

    2016-01-01

    Full Text Available Objective: This study aims to investigate healthcare professionals’ (HCPs general level of knowledge about sexually transmitted diseases, their attitudes towards these patients and legal aspects of medical services. Materials and Methods: This was a multi-centered study. The participants were given 28 questions that mainly asked their level of knowledge on sexually transmitted diseases (STDs patients, their attitudes towards such patients, and their legal as well as ethical views on them. Results: A total of 234 HCPs, 124 (53% female and 110 (47% male, participated in the study. The majority of married HCPs have reported monogamy as the most reliable protection method, whereas single participants have marked "condoms." The most commonly known STD has been reported as AIDS in all groups. Even though HCPs find it medically unethical not to offer a medical intervention to patients with STDs, more than one-third of the participants believe that HCPs should have the right not to do so. Conclusion: It has been concluded that HCPs need further education on STDs. Nevertheless, such high level of care and attention on HCPs’ part does not necessarily decrease their need for proper medico legal regulations on such issues.

  6. Setting up a radiotherapy programme: Clinical, medical physics, radiation protection and safety aspects

    International Nuclear Information System (INIS)

    The incidence of cancer is increasing, particularly because of the increase in life expectancy arising from worldwide improvements in standards of living. According to recent estimates of the International Agency for Research on Cancer (IARC) and the World Health Organization (WHO), approximately ten million new cases of cancer are being detected per year worldwide, with slightly more than half of the cases occurring in developing countries. By the year 2015 this number is expected to increase to about 15 million cases, of which two thirds will occur in developing countries. About half of all cancer patients receive radiotherapy, either as part of their primary treatment or in connection with recurrences or palliative treatment. Radiotherapy is a multidisciplinary specialty which uses complex equipment and radiation sources for the delivery of treatment. It is estimated that approximately 3300 teletherapy machines are currently installed in developing countries. This figure is significantly below the estimated needs, of almost 5000 machines at present and about 10 000 machines by the year 2015. Taking this into account, in addition to the great need for qualified professionals (radiation oncologists, medical radiotherapy physicists, radiotherapy technicians, radiation protection officers, maintenance engineers, etc.), the future development of the medical infrastructure for cancer treatment appears to be a substantial undertaking. While the present publication discusses radiation treatment programmes alone, it is recognized that other components of comprehensive cancer management programmes, such as cancer prevention and diagnosis, also need to be addressed. It is widely acknowledged that the clinical aspects (diagnosis, treatment decision making, indication for treatment and follow-up), as well as the procedures related to the physical and technical aspects of patient treatment, must be subjected to careful control and planning in order to ensure safe, high

  7. Dosimetric and medical aspects of the radiological accident in Goiania in 1987

    International Nuclear Information System (INIS)

    In September 1987, in Goiania, a city of one million inhabitants and capital of the Brazilian State of Goias, a rotating assembly of the shielding head of a teletherapy unit was removed and the capsule containing 50.9 TBq (1375 Ci) of 137Cs was dismantled. This serious radiological accident resulted in four fatalities, injuries to many people, and the widespread contamination of the central part of Goiania. This TECDOC describes the dosimetric and medical aspects of the Goiania accident, including the experience of some of the scientists and physicians who were involved in the management, monitoring and treatment of the victims. Many scientific papers have been published on the subject in different journals. This publication compiles up to data conclusions on the 10 year follow-up of the Goiania accident victims, and summarizes the experience that was acquired

  8. Biology and Mechanics of Blood Flows Part II: Mechanics and Medical Aspects

    CERN Document Server

    Thiriet, Marc

    2008-01-01

    Biology and Mechanics of Blood Flows presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. Part II of this two-volume sequence, Mechanics and Medical Aspects, refers to the extraction of input data at the macroscopic scale for modeling the cardiovascular system, and complements Part I, which focuses on nanoscopic and microscopic components and processes. This volume contains chapters on anatomy, physiology, continuum mechanics, as well as pathological changes in the vasculature walls including the heart and their treatments. Methods of numerical simulations are given and illustrated in particular by application to wall diseases. This authoritative book will appeal to any biologist, chemist, physicist, or applied mathematician interested in the functioning of the cardiovascular system.

  9. Practical aspects during sterilization validation for medical devices at IRASM Microbiological Laboratory

    International Nuclear Information System (INIS)

    Complete text of publication follows. The state of being free of living microorganisms is called sterility. The sterility state can be achieved by different means of sterilization. In practice the results of the process cannot be fully verified by tests, so the efficacy of the sterilization process must be validated. ISO 11137 established regulations for setting or substantiating the dose for achieving the desired sterility assurance level. The validation studies can be designed in particular for different types of product. Each product needs distinct protocol for bioburden determination and sterility testing. During time, the Microbiological Laboratories from Multipurpose Irradiation Center deals with different types of products, mainly for VDmax25 method. When it comes to microbiological evaluation the most challenging was cotton gauze. Special situation for establishing the sterilization validation method appears in cases of cotton, packed in large quantities. VDmax25 method can not be applied for items with average bioburden more than 1000 CFU / pack, no matter which is the weight of the package. This is a method limitation and implies increased costs for manufacturer, when choosing other method. For microbiological tests, culture condition should be selected in both cases the bioburden and sterility testing. These are time and money consuming. The costs can be reduced if taking into account some aspects. Reason for performing the bacteriostasis-fungistasis just for sterility testing will be given. The present study puts forward aspects during the validation studies for medical devices (cotton wool, cotton gauze, surgical sutures, dental screws), at IRASM Microbiological Laboratory.

  10. An Overview of Multiple Sclerosis: Medical, Psychosocial, and Vocational Aspects of a Chronic and Unpredictable Neurological Disorder

    Science.gov (United States)

    Rumrill, Phillip D., Jr.; Roessler, Richard T.

    2015-01-01

    This article presents an overview of multiple sclerosis (MS), one of the most common neurological disorders in the western hemisphere. Medical and psychosocial aspects of the disease such as causes and risk factors, diagnosis, incidence and prevalence, symptoms, courses, and treatment are described. Existing research regarding the employment…

  11. Safety aspects and patterns of medication use in pregnancy. With special focus on psychotropic medication and mental health

    OpenAIRE

    2015-01-01

    Use of medications, including psychotropics, is common during pregnancy. Indeed, many women might be in need of pharmacotherapy during pregnancy in order to ensure maternalfetal health. However, discordant findings or lack of information about neonatal and maternal safety after use of psychotropics, in particular antidepressants, have so far posed significant challenges on practicing clinicians when assessing the risk of pharmacotherapy versus the risk of not medicated maternal illness. In ad...

  12. Legal and medical aspects of the ethics committee’s work relating to abortion

    Directory of Open Access Journals (Sweden)

    Ponjavić Zoran

    2011-01-01

    Full Text Available This paper analyses the legal and medical aspects of the work of ethics committees on abortion. According to the legislation of the Republic of Serbia, these committees are competent to determine justifiable terms for abortion after the twentieth week of the fetus. It is well known that abortion is not only a medical but a legal, ethic, social and demographic problem as well. A liberal solution in view of abortion in the first trimester has been accepted in most European countries, as by the legislature of the Republic of Serbia. Since prenatal diagnosis cannot always determine the fetus state with certainty but at times may do so at a later stage, abortion is then required when the child is already capable of extrauterine life. The necessity for performing abortion in the third trimester is thus a result of good knowledge of techno-medicine but also from the limited information it provides. In such situations, the physician needs confirmation and justification of his standpoint with respect to abortion through a legal formulation which should contain "minimum moral". Society has found a way to protect and help him through moral and ethic forms of prevention without anybody’s emotions being affected. Ethics committees should thus help the physician in view of determining the terms for performing late abortion, since the rules of doctor’s ethics are not sufficient in this case. The article especially analyses the work of the Ethics Committee of the Clinical Center in Kragujevac in the period 2000-2010. It is stated that the largest number of cases referred to determined diseases or fetus anomalies while only a negligible number (11.29% to the illness of the mother. There were no requests for abortions due to legal reasons (pregnancies from criminal offences. A significant number (40.28% of requests submitted to the Ethics Committee related to pregnancies under the 24th week of pregnancy. Since a pregnancy of 24 weeks represents a boundary

  13. Ethical and hygiene aspects of the reprocessing of medical devices in Germany

    Directory of Open Access Journals (Sweden)

    Assadian, Ojan

    2008-09-01

    Full Text Available Based on safety and quality principles, for each medical device (MD, regardless of its declared status as single- or multi-use device, careful considerations must be made. This includes assessment whether reprocessing is economical and ecological meaningful, and technical feasible. So far, however, in Germany reprocessing of declared single use MD is legally allowed, provided that the above aspects are well covered. The purpose of this paper is to elucidate, when circumstances allow reprocessing of declared single-use MD. For reprocessing of single use MD the following preconditions must be fulfilled: * The security level of the reprocessed MD must be equivalent to the status of the newly delivered item; this means that a patient is not exposed to a higher risk through a reprocessed disposable MD than through the new, i.e. un-processed product. * The reprocessing must be based on a detailed risk assessment and risk analysis, and must be described in detail regarding selection of the reprocessing method. Additionally, all necessary safety- and quality assurance measures must be stated. * The reprocessing measure needs to be accompanied with a quality management system which determines and documents the responsibility of all stages of reprocessing; where the corresponding reprocessing procedures are well defined; and the efficacy of the procedure is proven by product-specific or product-group-specific tests and reports. The process must be validated according to recognised methods of science and technology, taking into account potential negative influences of the reprocessing on the properties of the material and the technical and functional safety. For reprocessing of MDs of the category Critical C the quality assurance must be certified by an accredited certifying body.

  14. Medical physics aspects of cancer care in the Asia Pacific region

    OpenAIRE

    2008-01-01

    Medical physics plays an essential role in modern medicine. This is particularly evident in cancer care where medical physicists are involved in radiotherapy treatment planning and quality assurance as well as in imaging and radiation protection. Due to the large variety of tasks and interests, medical physics is often subdivided into specialties such as radiology, nuclear medicine and radiation oncology medical physics. However, even within their specialty, the role of radiation oncology med...

  15. Organisational aspects of the qualification and involvement of Medical Physicists in Radiology

    International Nuclear Information System (INIS)

    The specialist in Medical Physics has a key position in Quality Assurance process at diagnostic and therapeutic process and in Radiation Protection at medical use of ionizing radiation. The International Basic Safety Standards for protection against ionizing radiation of IAEA recommend and the EURATOM Directives 96/23 and 97/43 require qualified expert in medical physics to be involved in all the activities with ionizing radiation. In radiotherapeutic process this expert shall be closely involved and in nuclear medicine and diagnostic radiology this specialist shall be available. The International Organization for Medical Physics (IOMP), the European Federation of Organizations for Medical Physics (EFOMP) as well as a number of national organizations for Medical Physics in different countries have a clear concept for the qualification levels of the medical physics specialists, for the recognition scheme of their qualification and for the organization of the medical physics activities in a clinical environment. The legal requirements for medical physics expert's involvement in medicine is introducing in Bulgaria with the new Ordinance for Radiation Protection of Individuals at Medical Exposure that is expected to come into force in the beginning of next year. Some problems for discussion are submitted here finding necessary changes in the existing system for education and training of Medical physicists as well as in the organization of their involvement in health centers in the country. (author)

  16. RESEARCH OF RUSSIAN HIGH TECHNOLOGY MEDICAL EQUIPMENT MARKET: THE SOCIO-ECONOMIC ASPECTS

    OpenAIRE

    Otstavnov Stanislav Sergeevich

    2013-01-01

    The article presents the data obtained from comprehensive study of russian hi-tech medical equipment market. The size and the structure of Russian medical equipment market in 2005-2011 were investigated and market size forecast for 2012-2015 was given. Priority segments of Russian high-tech medical equipment market were identified (products with a high degree of visualization, anesthetic and ventilation equipment, patient monitors)  based on the analysis of literature sources and morbidity st...

  17. Medical physics aspects of cancer care in the Asia Pacific region: 2011 survey results

    OpenAIRE

    2012-01-01

    Background: Medical physicists are essential members of the radiation oncology team. Given the increasing complexity of radiotherapy delivery, it is important to ensure adequate training and staffing. The aim of the present study was to update a similar survey from 2008 and assess the situation of medical physicists in the large and diverse Asia Pacific region. Methods: Between March and July 2011, a survey on profession and practice of radiation oncology medical physicists (ROMPs) in the Asi...

  18. Medical and Social Aspects of Syphilis in the Balkans from the mid-19th Century to the Interwar

    Directory of Open Access Journals (Sweden)

    Tsiamis Costas

    2016-03-01

    Full Text Available The current study presents some aspects of syphilis in the Balkan Peninsula from the 19th century until the Interwar. Ever since the birth of modern Balkan States (Greece, Bulgaria, Turkey and Serbia, urbanization, poverty and the frequent wars have been considered the major factors conducive to the spread of syphilis. The measures against sex work and sexually transmitted diseases (STDs were taken in two aspects, one medical and the other legislative. In this period, numerous hospitals for venereal diseases were established in the Balkan countries. In line with the international diagnostic approach and therapeutic standards, laboratory examinations in these Balkan hospitals included spirochete examination, Wassermann reaction, precipitation reaction and cerebrospinal fluid examination. Despite the strict legislation and the adoption of relevant laws against illegal sex work, public health services were unable to curb the spread of syphilis. Medical and social factors such as poverty, citizen’s ignorance of STDs, misguided medical perceptions, lack of sanitary control of prostitution and epidemiological studies, are highlighted in this study. These factors were the major causes that helped syphilis spread in the Balkan countries during the 19th and early 20th century. The value of these aspects as a historic paradigm is diachronic. Failure to comply with the laws and the dysfunction of public services during periods of war or socioeconomic crises are both factors facilitating the spread of STDs.

  19. Medical and Social Aspects of Syphilis in the Balkans from the mid-19th Century to the Interwar.

    Science.gov (United States)

    Tsiamis, Costas; Vrioni, Georgia; Poulakou-Rebelakou, Effie; Gennimata, Vasiliki; Murdjeva, Mariana А; Tsakris, Athanasios

    2016-03-01

    The current study presents some aspects of syphilis in the Balkan Peninsula from the 19th century until the Interwar. Ever since the birth of modern Balkan States (Greece, Bulgaria, Turkey and Serbia), urbanization, poverty and the frequent wars have been considered the major factors conducive to the spread of syphilis. The measures against sex work and sexually transmitted diseases (STDs) were taken in two aspects, one medical and the other legislative. In this period, numerous hospitals for venereal diseases were established in the Balkan countries. In line with the international diagnostic approach and therapeutic standards, laboratory examinations in these Balkan hospitals included spirochete examination, Wassermann reaction, precipitation reaction and cerebrospinal fluid examination. Despite the strict legislation and the adoption of relevant laws against illegal sex work, public health services were unable to curb the spread of syphilis. Medical and social factors such as poverty, citizen's ignorance of STDs, misguided medical perceptions, lack of sanitary control of prostitution and epidemiological studies, are highlighted in this study. These factors were the major causes that helped syphilis spread in the Balkan countries during the 19th and early 20th century. The value of these aspects as a historic paradigm is diachronic. Failure to comply with the laws and the dysfunction of public services during periods of war or socioeconomic crises are both factors facilitating the spread of STDs. PMID:27383872

  20. Antecedents of the People and Organizational Aspects of Medical Informatics: Review of the Literature

    OpenAIRE

    Lorenzi, Nancy M.; Riley, Robert T.; Blyth, Andrew J. C.; Southon, Gray; Dixon, Bradley J.

    1997-01-01

    People and organizational issues are critical in both implementing medical informatics systems and in dealing with the altered organizations that new systems often create. The people and organizational issues area—like medical informatics itself—is a blend of many disciplines. The academic disciplines of psychology, sociology, social psychology, social anthropology, organizational behavior and organizational development, management, and cognitive sciences are rich with...

  1. Groundwater Chemistry and Assessment of Its Effect on Health from the Aspect of Medical Geology

    Directory of Open Access Journals (Sweden)

    Simge Varol

    2008-08-01

    Full Text Available Geology and medicine are the oldest two sciences. Nowadays, medical geology is appeared to associate the researches related to environmental problems studied by geology and medical sciences. In the medical geology, researches related to effect of groundwater on human health is the most important subject. In this paper, elements which are the constituent of groundwater and health problems originated from those elements were explained. In addition, components polluting the groundwater widely were presented in detail. [TAF Prev Med Bull 2008; 7(4.000: 351-356

  2. Legislative and ethical aspects of introducing new technologies in medical care for senior citizens in developed countries

    Directory of Open Access Journals (Sweden)

    Kacetl J

    2016-07-01

    Full Text Available Jaroslav Kacetl,1 Petra Maresova2 1Department of Applied Linguistics, 2Department of Economics, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic Introduction: The majority of developed countries are currently experiencing demographic aging. The most frequently expressed concerns related to the changing age structure are the increased costs of social and medical care, a lack of labor force in the job market, and financial sustainability of the pension system. These concerns are often based on the pessimistic view of population aging. This view understands aging as a prolonged period of illness and suffering. On the other hand, optimists believe that a longer life span is a result of increased quality of life and better health care. The quality of life may be improved not only by medicaments, but also by rapidly developing area of medical devices, which allow better care for seniors in many areas.Aim: This contribution aims to assess the legislative environment and ethical questions related to the use of medical devices, especially medical devices, in medical care for senior citizens.Methods: The methods used in this study are literature reviews of legislative and ethical environment in the European Union (EU and the US.Results: Main findings of this study result from assessing the state of medical device regulations in Europe and the US. Namely, the US regulation seems to be better arranged, which is probably due to the fact that there is only one responsible body – the US Food and Drug Administration, which is responsible for all medical device regulations. On the other hand, in the EU, talks about new legislation are led by ministers from all the EU member states and it may take a long time before all the EU countries come to an agreement. Keywords: senior citizen, medical devices, legislation, ethical aspects

  3. RESEARCH OF RUSSIAN HIGH TECHNOLOGY MEDICAL EQUIPMENT MARKET: THE SOCIO-ECONOMIC ASPECTS

    Directory of Open Access Journals (Sweden)

    Станислав Сергеевич Отставнов

    2013-04-01

    Full Text Available The article presents the data obtained from comprehensive study of russian hi-tech medical equipment market. The size and the structure of Russian medical equipment market in 2005-2011 were investigated and market size forecast for 2012-2015 was given. Priority segments of Russian high-tech medical equipment market were identified (products with a high degree of visualization, anesthetic and ventilation equipment, patient monitors  based on the analysis of literature sources and morbidity structure. Key players in key segments of the market were identified and their financial performance such as number of employees, revenue, net profit, researches and development expenses were compared (according to actual annual reports.Research allowed to draw the following conclusion: today in the key segments of Russian high-tech medical equipment market the leadership of foreign companies  (Hitachi, Philips, Siemens, Toshiba, General Electric, Dräger is indisputable, objective preconditions for the fundamental change of the situation are absent. Import substitution requires the consolidation of domestic producers, adequate funding and human resource.The results can be used in practice by medical industry companies and State authorities on purpose to upgrade the medical industry.DOI: http://dx.doi.org/10.12731/2218-7405-2013-1-31

  4. RESEARCH OF RUSSIAN HIGH TECHNOLOGY MEDICAL EQUIPMENT MARKET: THE SOCIO-ECONOMIC ASPECTS

    Directory of Open Access Journals (Sweden)

    Otstavnov Stanislav Sergeevich

    2013-01-01

    Full Text Available The article presents the data obtained from comprehensive study of russian hi-tech medical equipment market. The size and the structure of Russian medical equipment market in 2005-2011 were investigated and market size forecast for 2012-2015 was given. Priority segments of Russian high-tech medical equipment market were identified (products with a high degree of visualization, anesthetic and ventilation equipment, patient monitors based on the analysis of literature sources and morbidity structure. Key players in key segments of the market were identified and their financial performance such as number of employees, revenue, net profit, researches and development expenses were compared (according to actual annual reports. Research allowed to draw the following conclusion: today in the key segments of Russian high-tech medical equipment market the leadership of foreign companies (Hitachi, Philips, Siemens, Toshiba, General Electric, Dräger is indisputable, objective preconditions for the fundamental change of the situation are absent. Import substitution requires the consolidation of domestic producers, adequate funding and human resource. The results can be used in practice by medical industry companies and State authorities on purpose to upgrade the medical industry.

  5. Carbohydrate Metabolism Disorders

    Science.gov (United States)

    ... in your body tissues. If you have a metabolic disorder, something goes wrong with this process. Carbohydrate metabolism disorders are a group of metabolic disorders. Normally your enzymes break carbohydrates down into glucose ( ...

  6. Medical and radiological aspects of emergency preparedness and response at SevRAO facilities

    International Nuclear Information System (INIS)

    Regulatory cooperation between the Norwegian Radiation Protection Authority and the Federal Medical Biological Agency (FMBA) of the Russian Federation has the overall goal of promoting improvements in radiation protection in Northwest Russia. One of the projects in this programme has the objectives to review and improve the existing medical emergency preparedness capabilities at the sites for temporary storage of spent nuclear fuel and radioactive waste. These are operated by SevRAO at Andreeva Bay and in Gremikha village on the Kola Peninsula. The work is also intended to provide a better basis for regulation of emergency response and medical emergency preparedness at similar facilities elsewhere in Russia. The purpose of this paper is to present the main results of that project, implemented by the Burnasyan Federal Medical Biophysical Centre. The first task was an analysis of the regulatory requirements and the current state of preparedness for medical emergency response at the SevRAO facilities. Although Russian regulatory documents are mostly consistent with international recommendations, some distinctions lead to numerical differences in operational intervention criteria under otherwise similar conditions. Radiological threats relating to possible accidents, and related gaps in the regulation of SevRAO facilities, were also identified. As part of the project, a special exercise on emergency medical response on-site at Andreeva Bay was prepared and carried out, and recommendations were proposed after the exercise. Following fruitful dialogue among regulators, designers and operators, special regulatory guidance has been issued by FMBA to account for the specific and unusual features of the SevRAO facilities. Detailed sections relate to the prevention of accidents, and emergency preparedness and response, supplementing the basic Russian regulatory requirements. Overall it is concluded that (a) the provision of medical and sanitary components of emergency

  7. Myelodysplastic syndromes: aspects of current medical care and economic considerations in Germany.

    Science.gov (United States)

    Gattermann, Norbert; Hofmann, Wolf-Karsten; Meessen, Axel; Schmitz, Stephan; Tsamaloukas, Anton; Vollmer, Tanja; Wedding, Ulrich; Plesnila-Frank, Carlotta; Schramm, Wolfgang; Berger, Karin

    2008-09-01

    Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases mainly affecting older people. The use of an increasing number of therapeutic options depends on a systematic risk stratification of the patients. A high percentage of MDS patients need blood transfusions as supportive care, which influence quality of life and cause a great part of the costs generated by MDS therapy. In this article which is based on a workshop about the burden of MDS held in October 2006 in Munich, MDS is discussed with regard to different aspects: current therapies, transfusion medicine, geriatrics, quality of life, and health economic aspects. PMID:18787357

  8. ADVANTAGES OF PLASTINATED HUMAN BODY IN MEDICAL EDUCATION AND ITS LEGAL & ETHICAL ASPECTS

    Directory of Open Access Journals (Sweden)

    Chaturvedi

    2014-03-01

    Full Text Available Plastination is a scientific procedure or technique of preservation of body or body parts useful in anatomy and forensic medicine department for medical education. Exhibition of preserved human body and body parts, that are prepared using a plastination technique revealing inner anatomical structures, is called Body Worlds (German title: “Körperwelten”. The use of plastinated specimens has greatly assisted students in their understanding of anatomy and gross pathology and their being able to correlate these specimens with radio graphical images of the human body. Several ethical and legal questions may arise while considering adoption of a plastinated human body as teaching tools in medical education. Here, we have focused our attention over basic scientific concepts with legal and ethical issues in relation to use of plastinated human bodies in medical education.

  9. Antecedents of the people and organizational aspects of medical informatics: review of the literature.

    Science.gov (United States)

    Lorenzi, N M; Riley, R T; Blyth, A J; Southon, G; Dixon, B J

    1997-01-01

    People and organizational issues are critical in both implementing medical informatics systems and in dealing with the altered organizations that new systems often create. The people and organizational issues area--like medical informatics itself--is a blend of many disciplines. The academic disciplines of psychology, sociology, social psychology, social anthropology, organizational behavior and organizational development, management, and cognitive sciences are rich with research with significant potential to ease the introduction and on-going use of information technology in today's complex health systems. These academic areas contribute research data and core information for better understanding of such issues as the importance of and processes for creating future direction; managing a complex change process; effective strategies for involving individuals and groups in the informatics effort; and effectively managing the altered organization. This article reviews the behavioral and business referent disciplines that can potentially contribute to improved implementations and on-going management of change in the medical informatics arena. PMID:9067874

  10. Molecular simulations of carbohydrate-protein complexes

    OpenAIRE

    Eid, Sameh Mansour Abbas

    2013-01-01

    I. Generation and validation of a free-energy model for carbohydrate binding. Carbohy-drates play a key role in a variety of physiological and pathological processes and, hence, represent a rich source for the development of novel therapeutic agents. Being able to predict binding mode and binding affinity is an essential, yet lacking, aspect of the stru-cture-based design of carbohydrate-based ligands. To this end, we assembled a diverse data set of 316 carbohydrate–protein crystal structu...

  11. Ethical aspect in medical radiation use; Ethische Aspekte der medizinischen Strahlenanwendung

    Energy Technology Data Exchange (ETDEWEB)

    Kiefer, Juergen

    2014-07-01

    Medical radiation uses hold a specific position in radiation protection. Patients are purposely exposed to radiation while usually radiation exposure should be avoided. The radiation doses are (at least in principle) planned the risks may be estimated (again in principle). The hazards are justified by the medical benefit. Otherwise irradiation is a violation of physical integrity (article 2 Grundgesetz) that can be prosecuted. For patients no dose limits exist, the responsible physician decides on the real exposures. Justification and optimization are of predominant importance. The decision on the radiological measure, the applied technology is an ethically motivated decision besides the everyday routine.

  12. Utilization of carbohydrates by radiation processing

    Science.gov (United States)

    Kume, T.; Nagasawa, N.; Yoshii, F.

    2002-03-01

    Upgrading and utilization of carbohydrates such as chitosan, sodium alginate, carrageenan, cellulose, pectin have been investigated for recycling these bio-resources and reducing the environmental pollution. These carbohydrates were easily degraded by irradiation and various kinds of biological activities such as anti-microbial activity, promotion of plant growth, suppression of heavy metal stress, phytoalexins induction, etc. were induced. On the other hand, some carbohydrate derivatives, carboxymethylcellulose and carboxymethylstarch, could be crosslinked under certain radiation condition and produce the biodegradable hydrogel for medical and agricultural use.

  13. Medication for older people - aspects of rational therapy from the general practitioner's point of view

    DEFF Research Database (Denmark)

    Vass, M; Hendriksen, C

    2005-01-01

    prescribing practices.The authors recommend and present tools enabling the GP to focus on 'the core prescribing situation'. The logistics to optimise medication including compliance, the use of modern IT and better collaboration and communication between primary and secondary care are discussed. The authors...... social activity (including basal aids for hearing and sight)....

  14. [Medical aspects and driving history of drivers with higher class automobile driver's licenses].

    Science.gov (United States)

    Maag, F

    1982-02-01

    In the medical part of our paper we have shown the chauffeurs are a high-risk group with respect to hypertension, lumbar pain, and overweight. The analysis of drivers' offenses, yearly kilometers driven and years of driving in the three groups of taxi, lorry and coach drivers shows that coach chauffeurs have significantly better driving records. PMID:6461985

  15. Medical physics aspects of cancer care in the Asia Pacific region: 2014 survey results.

    Science.gov (United States)

    Kron, Tomas; Azhari, H A; Voon, E O; Cheung, K Y; Ravindran, P; Soejoko, D; Inamura, K; Han, Y; Ung, N M; TsedenIsh, Bolortuya; Win, U M; Srivastava, R; Marsh, S; Farrukh, S; Rodriguez, L; Kuo, Men; Baggarley, S; DilipKumara, A H; Lee, C C; Krisanachinda, A; Nguyen, X C; Ng, K H

    2015-09-01

    It was the aim of this work to assess and track the workload, working conditions and professional recognition of radiation oncology medical physicists (ROMPs) in the Asia Pacific region over time. In this third survey since 2008, a structured questionnaire was mailed in 2014 to 22 senior medical physicists representing 23 countries. As in previous surveys the questionnaire covered seven themes: 1 education, training and professional certification, 2 staffing, 3 typical tasks, 4 professional organisations, 5 resources, 6 research and teaching, and 7 job satisfaction. The response rate of 100% is a result of performing a survey through a network, which allows easy follow-up. The replies cover 4841 ROMPs in 23 countries. Compared to 2008, the number of medical physicists in many countries has doubled. However, the number of experienced ROMPs compared to the overall workforce is still small, especially in low and middle income countries. The increase in staff is matched by a similar increase in the number of treatment units over the years. Furthermore, the number of countries using complex techniques (IMRT, IGRT) or installing high end equipment (tomotherapy, robotic linear accelerators) is increasing. Overall, ROMPs still feel generally overworked and the professional recognition, while varying widely, appears to be improving only slightly. Radiation oncology medical physics practice has not changed significantly over the last 6 years in the Asia Pacific Region even if the number of physicists and the number and complexity of treatment techniques and technologies have increased dramatically. PMID:26346030

  16. Health aspects of Arctic exploration – Alaska's medical history based on the research files of Dr. Robert Fortuine

    Directory of Open Access Journals (Sweden)

    Kathleen Murray

    2013-08-01

    Full Text Available Background . Robert Fortuine provided basic medical care to Alaska Native people, chronicled the Health Aspects of Arctic Exploration and through a number of influential publications, was the first to thoroughly document and analyse Alaska's Medical History. This overview of his published work will provide the reader with a detailed overview, so that they can begin to explore Dr. Fortuine's many published works in more detail. Objective . This review will explore Alaska's Medical History and the Health Aspects of Arctic Exploration through the research files and the 10 most significant publications of Dr. Robert Fortuine. Design . Review of Dr. Fortuine's major works and the master bibliography has over 3,000 references and 81 subjects. The master bibliography is a merger of 55 separate bibliographies, which provides a wealth of bibliographic information. This paper will describe his 10 most significant publications, 2 of which began as a journal issue. Results . Dr. Fortuine was a prolific writer throughout his career, publishing 134 articles and books. He wrote papers and books on Alaska's medical history, tuberculosis and health care delivery from Russian–America through the Public Health Service efforts in the territory and then the State of Alaska. The master bibliography has over 3,000 references and 81 subjects. This list has a significant number of entries for tuberculosis with almost one-third of the entries including this heading. Others dwell on the history of “pre-contact” health, the history of Alaska Native health care, the history of the Alaska Department of Health, especially the tuberculosis programme, the role of the US Public Health Service and traditional medicine. He completely reviewed every Governors’ and the US Surgeon General's reports in regard to Alaska content. This paper describes his 10 most significant publications. Conclusions . Robert Fortuine's published works offer a wealth of information and insight

  17. Can eosinophilic bronchitis be considered as an occupational disease? Medical certification aspects

    Directory of Open Access Journals (Sweden)

    Aneta Kleniewska

    2013-08-01

    Full Text Available Eosinophilic bronchitis (EB is a condition which can be associated with occupational exposure to low, as well as to high molecular weight allergens. The prevalence of occupational eosinophilic bronchitis is unknown and the data concerning its work-related etiology are available only from the case reports. However, there is a need to establish the principles, especially in the context of medical certification among workers occupationally exposed to allergens. This paper reviews current knowledge on the etiology, clinical features, and diagnostic procedures in the eosinophilic bronchitis. The importance of EB, especially in view of the problems emerging in the prophylactic care taken by occupational health services and the principles of medical certification when occupational etiology is suspected are also presented. Med Pr 2013;64(4:569–578

  18. Medical and Social Aspects of High Amputations in Patients with Obliterating Atherosclerosis of Lower Extremities

    OpenAIRE

    Gudz, I. M.; Hnatyshchak, A. I.

    2014-01-01

    Obliterating atherosclerosis of the lower extremities is one of the main causes of limb ischemia, that can result in high amputation of the lower limb (HALL). Despite the large number of publications on this subject, medical and social effects of HALL on the patients’ life are studied insufficiently. In some studies a significant impact of financial situation, the level of education, and accessibility of qualified vascular surgery care on the HALL index was stated. As this intervention is con...

  19. Overview of legal aspects of Continuing Medical Education/ Continuing Professional Development in Georgia

    OpenAIRE

    Chakhava, George; Kandelaki, Nino

    2013-01-01

    Improved patient safety and quality of health care are of great importance to the Continuing Medical Education/Continuing Professional Development (CME/CPD) system in Georgia. In particular, those involved in the delivery of frontline care have an inherent duty to ensure that they are competent and skilful in providing good care for patients. An effective system should support physicians across a number of key areas including: • Providing patient care; • Promoting health improvement, wellness...

  20. Epidemiologic Aspects of Medical Retirement from the Republic of Korea Army due to Visual Impairment.

    Science.gov (United States)

    Jeong, Jae Hoon; Chun, Yeoun Sook; Park, Ki Ho

    2016-04-01

    This study was done to report the epidemiologic characteristics of medical retirement from the Republic of Korea (ROK) Army due to visual impairment and to suggest a practical screening system for the draft. The medical records of 423 eyes of 301 patients who retired from the ROK Army due to visual impairment were reviewed retrospectively between January 2010 and December 2014. The patients were grouped by the presence of trauma, and each group was subdivided by military rank. We analyzed demographic and ophthalmic data, including the etiology of ophthalmologic disease. The etiology was classified into 5 anatomical categories (ocular surface, lens, retina, optic nerve and extraocular visual pathway, and extraocular muscle and orbit), which were then subdivided into the type of disease. The mean age was 24.5 years, and non-traumatic mechanisms accounted for 81.1% (343/423 eyes) of medical retirements. Visual acuity was better in patients without trauma. In enlisted soldiers, disease in the optic nerve and extraocular visual pathway was the most common anatomical category (40.5%), and primary open angle glaucoma (30.8%), retinal dystrophy (18.3%), congenital cataract (14.5%), and retinal detachment (9.7%) were the four most common diseases. Most medical retirements due to visual impairment resulted from non-traumatic mechanisms, even though patients were young. The fundus examination and visual field test would be more useful tools than a conventional vision test for large-scale draft screening for the most common two disease types: primary open angle glaucoma and retinal dystrophy. PMID:27051249

  1. ADVANTAGES OF PLASTINATED HUMAN BODY IN MEDICAL EDUCATION AND ITS LEGAL & ETHICAL ASPECTS

    OpenAIRE

    Chaturvedi; Anurag; Praveen; Abha; Mishra,, A.N.

    2014-01-01

    Plastination is a scientific procedure or technique of preservation of body or body parts useful in anatomy and forensic medicine department for medical education. Exhibition of preserved human body and body parts, that are prepared using a plastination technique revealing inner anatomical structures, is called Body Worlds (German title: “Körperwelten”). The use of plastinated specimens has greatly assisted students in their understanding of anatomy and gross pathology and their being able to...

  2. Aspects of Medical and Psychological Rehabilitation of Patients after Aesthetic Breast Surgery

    OpenAIRE

    Kirill V. Gordon; Eduard S. Khudoev

    2013-01-01

    Breast prosthesis with aesthetic purposes is widespread throughout the world and has been rapidly spreading within Russia in recent years. Since the frequency of breast postoperative complications and repeated surgery does not tend to decrease, it is advisable to examine patients more thoroughly to choose the appropriate surgery. Postoperative medical rehabilitation is also required to improve the psycho-emotional state, prevent early and delayed postoperative complications and increase the q...

  3. ATTITUDE AND KNOWLEDGE OF MEDICAL STUDENTS ON PRACTICAL ASPECTS OF FORENSIC MEDICINE

    Directory of Open Access Journals (Sweden)

    Nihal

    2015-07-01

    Full Text Available This study explored medical students’ knowledge and attitude on the medico - legal autopsy demonstrations which formed part of their training in Forensic Medicine. 300 students of 2010, 2011 and 2012 batch of college were obtained by asking them to answer a questionnaire on the subject. The students were asked to respond anonymously to a questionnaire which dealt with their views on the autopsy practice, the knowledge of the procedure, attitude and perception towards medico legal autopsy. In present study majority of the students were aware of the situations where medico legal postmortem examination is mandatory as per Indian law and taking out of viscera for chemical analysis and histo - pathological examination for the purpose of medico - legal autopsy. 96% of the students agreed that autopsy is necessary in medical education. 37.95% of the students were very uncomfortable on the first exposure to postmortem examination. This study showed that medical students appreciate the medico - legal autopsy demonstration as a learning experience.

  4. Radionuclides for therapeutic applications: Biological and medical aspects (present status, development and expectations)

    International Nuclear Information System (INIS)

    Different multidisciplinary therapeutic strategies and technical approaches are used today in cancer therapy. Among the techniques involving ionizing radiation, therapeutic applications of radioactive nuclides deserve a particular interest ; some clinical indications are well established, while several others are now being investigated, and some of them are promising. The efficacy of radionuclides in therapy often depends on technical factors such as specific activity, purity, chemical presentation, availability, etc. These factors are closely related, at least partly, to the production methods. This justifies the organization of the present Consultant's meeting by the IAEA. Brief information on cancer, its socio-economic aspects, and some data concerning cure rate are presented first

  5. Stem cells: An insight into the therapeutic aspects from medical and dental perspectives.

    Science.gov (United States)

    Sivakumar, Muniapillai; Dineshshankar, Janardhanam; Sunil, P M; Nirmal, R Madhavan; Sathiyajeeva, J; Saravanan, Balasubramanian; Senthileagappan, A R

    2015-08-01

    The recent advancements in the field of stem cell (SC) biology have increased the hope of achieving the definitive treatments for the diseases which are now considered incurable such as diabetes, Parkinson's disease and other chronic long standing conditions. To achieve this possibility, it is necessary to understand the basic concepts of SC biology to utilize in various advanced techniques of regenerative medicine including tissue engineering and gene therapy. This article highlights the types of SCs available and their therapeutic capacity in regenerative medical and dental fields. PMID:26538878

  6. Database for a systems analytical approach to studying the medical aspects of the Chernobyl accident

    International Nuclear Information System (INIS)

    The main elements of the program data base were the all-Union distribution register and the SDACHA computer system (Chernobyl accident data system) which ensured reliable functioning of the PRIORRA expert system (acronym stands for ''taking of optimum decisions in the event of a radiation accident''). The development of criteria for the optimum selection of countermeasures follows three paths - medical, economic and social - and is based on a regulatory document entitled ''criteria for taking decisions or measures to protect the population in the event of a reactor accident''. (author). 1 ref., 3 figs

  7. The use of stimulant medications for non-core aspects of ADHD and in other disorders.

    Science.gov (United States)

    Sinita, Eugenia; Coghill, David

    2014-12-01

    Psychostimulants play a central role in the management of ADHD. Here we review the evidence pertaining to the use of methylphenidate, dexamphetamine and related amphetamine salts, the prodrug lisdexamfetamine and modafinil for the management of comorbid ADHD and non-ADHD indications. There is a growing consensus that stimulant medications are helpful at improving the emotional dysregulation and lability, and oppositional and conduct symptoms that are often associated with ADHD. There is some evidence that psychostimulants may improve outcomes in those with treatment resistant depression, reduce negative symptoms and improve cognitive performance in schizophrenia, and that methylphenidate may reduce binge eating in those with bulimia nervosa. In general medicine, whilst the evidence is at times contradictory, psychostimulants have been shown in some studies to be effective treatments for chronic fatigue and narcolepsy, and to improve outcomes post stroke, post head injury, in dementia and various cancers. It seems likely that these effects often result from a combination of, reduction in fatigue, improvements in concentration and cognitive functioning and a lifting of mood which may be a direct or indirect consequence of the medication. Further studies seem warranted and these should focus on efficacy, effectiveness and long term safety. This article is part of the Special Issue entitled 'CNS Stimulants'. PMID:24951855

  8. Longitudinal PBL in Undergraduate Medical Education Develops Lifelong-Learning Habits and Clinical Competencies in Social Aspects.

    Science.gov (United States)

    Okubo, Yumiko; Matsushita, Susumu; Takakuwa, Yuichi; Yoshioka, Toshimasa; Nitta, Kosaku

    2016-01-01

    Problem-based learning (PBL) is popular in medical education in Japan. We wished to understand the influence of PBL on the clinical competence of medical residents, using self-assessment and observer assessment. Tokyo Women's Medical University (TWMU) implemented PBL longitudinally (long-time) for four years, and on this basis we analyzed whether long-time PBL education is useful for clinical work. A self-assessment questionnaire was sent to junior and senior residents who were alumni of several schools, and an observation-based assessment questionnaire to senior doctors instructing them. Respondents were asked if they had used the PBL process in daily clinical tasks, and if so in what processes. Senior doctors were asked whether TWMU graduates perform differently from graduates of other schools. TWMU graduates answered "used a lot" and "used a little" with regard to PBL at significantly higher rates than other graduates. As useful points of PBL, they mentioned extracting clinical problems, solving clinical problems, self-directed leaning, positive attitude, collaboration with others, presentation, doctor-patient relations, self-assessment, and share the knowledge with doctors at lower levels and students. Observer assessments of TWMU graduates by senior doctors represented them as adaptive, good at presenting, good at listening to others' opinions, practical, selfish, and eager in their instructional practice. Longitudinal PBL can be a good educational method to develop lifelong-learning habits and clinical competencies especially in terms of the social aspect. PMID:26725844

  9. Carbohydrates in Supramolecular Chemistry.

    Science.gov (United States)

    Delbianco, Martina; Bharate, Priya; Varela-Aramburu, Silvia; Seeberger, Peter H

    2016-02-24

    Carbohydrates are involved in a variety of biological processes. The ability of sugars to form a large number of hydrogen bonds has made them important components for supramolecular chemistry. We discuss recent advances in the use of carbohydrates in supramolecular chemistry and reveal that carbohydrates are useful building blocks for the stabilization of complex architectures. Systems are presented according to the scaffold that supports the glyco-conjugate: organic macrocycles, dendrimers, nanomaterials, and polymers are considered. Glyco-conjugates can form host-guest complexes, and can self-assemble by using carbohydrate-carbohydrate interactions and other weak interactions such as π-π interactions. Finally, complex supramolecular architectures based on carbohydrate-protein interactions are discussed. PMID:26702928

  10. [Medical and legal aspects of genital mutilation and circumcision part I: female genital mutilation (FGM)].

    Science.gov (United States)

    Dettmeyer, Reinhard; Laux, Johannes; Friedl, Hannah; Zedler, Barbara; Bratzke, Hansjürgen; Parzeller, Markus

    2011-01-01

    Female genital mutilation (FGM) is considered to be against the law and against morality not only in Western countries, although a woman of age and able to consent may sometimes think differently. The procedure may have serious physical and emotional consequences for the girl or woman. Nevertheless there are attempts to justify the procedure with medical and hygienic pseudoarguments, ideology, freedom of religion, cultural identity and social adequacy. Outside the Western world, some people claim that religion and culture alone justify the practice. In Germany, parents can lose the right to determine the residence of their daughter, if she is faced with the risk of genital mutilation in order to prevent that the child or girl is taken to her home country. Genital mutilation as a gender-specific threat is recognized as a reason to grant asylum or prevent deportation. Proposals to make genital mutilation a separate punishable offence are presently discussed by the legislator. PMID:21404547

  11. [Aspects of the mind-body relationship in the perspective of medical history].

    Science.gov (United States)

    Andersen, Lars Ole

    2009-01-01

    In the article three kinds of history writing about the mind-body relationship are presented: History as a puzzle, history as a connection of important pieces into meaningful narrative traditions and history as an investigation into the changing importance and meaning of concepts and discussions in medical history. In particular, ideas behind "Begriffsgeschichte" are presented in detail. The history of imagination is given as an example of the usefulness of tracing concepts and discussions back in time and looking for modern representations. Discussions on the power of imagination initiated the first clinical trials in the 18th century. Emphasis on the power of the mind, self-efficacy and self-care has today substituted earlier discussions on the power of imagination. PMID:20509455

  12. [Medical, psychological, social and gender aspects of aging in modern Russia].

    Science.gov (United States)

    Miakotnykh, V S; Sidenkova, A P; Borovkova, T A; Berezina, D A

    2014-01-01

    In this article, the authors considered controversial issues ambiguous attitude to the aging process of the population of the Russian Federation on the basis of a number of individual differences--psychological, social, sexual, and medical. The thesis is that, unfortunately, the fight against aging appears rather to be more a struggle with an already existing old age, and you need to develop preventive measures against aging much earlier than is currently done. Submissions own research confirm this position. The system of training, adjustment to a new level of life, to the new conditions associated with aging process, in the form of a special kind of multidisciplinary centers that carry out the tasks of improving health and young is proposed. PMID:25306663

  13. The Case of Pharmacological Neuroenhancement: Medical, Judicial and Ethical Aspects from a German Perspective.

    Science.gov (United States)

    Franke, A G; Northoff, R; Hildt, E

    2015-11-01

    Pharmacological neuroenhancement (PN) describes the use of psychoactive drugs for the purpose of enhancing cognition (e. g., fatigue, concentration, memory etc.) by healthy subjects without medical need. Drugs used for this purpose can be divided into freely available, over-the-counter drugs (e. g., methylxanthines such as caffeine), prescription drugs (e. g., antidementia drugs, methylphenidate) and illicit drugs (e. g., illicit amphetamines). Clinical studies have shown that the aforementioned substances only have limited pro-cognitive effects and have considerable safety risks and side effects.The German judicial perspective shows legal differences between substances (drugs, food, food supplements, fortified food) that can be bought in a supermarket, drugs that can be bought in a pharmacy as over-the-counter- (OTC-) drugs, drugs with or without the need for a prescription and illicit drugs. Supermarket drugs and fortified food can be sold freely and follow the general rules of civil and penal law; regarding acquisition, parents are responsible for their children. OTC drugs require special information about therapy. Regarding prescription drugs, there are legal problems caused by an off-label use and the non-medical purposes of PN drugs. Furthermore, prescription stimulants for PN are governed by the specialized law for narcotics, and their use might be punished. Beyond the general lack of rules for regulation for PN drug use there are specific needs for prevention (e. g., control of the black market, etc.).Possible future policy will depend, among others, on the probability with which effective PN drugs with an acceptable risk-benefit ratio will be available, on individual and societal implications, and on public opinion towards PN. While 4 different general policy scenarios can be identified, it is important to advance a broad societal debate on PN to collect relevant empirical data and to address enhancement-related conceptual issues. PMID:26252723

  14. Perfil da automedicação no Brasil Aspects of self-medication in Brazil

    Directory of Open Access Journals (Sweden)

    Paulo Sérgio D. Arrais

    1997-02-01

    Full Text Available INTRODUÇÃO: Os dados apresentados fazem parte de um estudo multicêntrico sobre automedicação na América Latina realizado pela Organização Mundial de Saúde (OMS. Objetivou-se traçar um perfil da automedicação através da análise da procura de medicamentos em farmácias sem prescrição médica ou aconselhamento do farmacêutico/balconista. MATERIAL E MÉTODO: As especialidades farmacêuticas foram classificadas pelo código "Anatomical Therapeutical Classification" e analisadas sob quatro aspectos qualitativos: valor intrínseco, essencialidade (lista da OMS e Relação Nacional de Medicamentos Essenciais (RENAME, combinação em dose fixa e necessidade de prescrição médica. RESULTADOS: Foram solicitadas 5.332 especialidades farmacêuticas (785 diferentes princípios ativos, sendo 49,5% combinações em dose fixas, 53,0% de valor intrínseco não elevado, 44,1% sujeitos a prescrição médica, 71,0% não essenciais e 40,0% baseados em prescrições médicas anteriores. Os medicamentos mais solicitados foram analgésicos (17,3%, descongestionantes nasais (7,0%, antiinflamatório/antireumático e antiinfecciosos de uso sistêmico, ambos com 5,6%. CONCLUSÕES: Os dados sugerem que a automedicação no Brasil reflete as carências e hábitos da população, é consideravelmente influenciada pela prescrição médica e tem a sua qualidade prejudicada pela baixa seletividade do mercado farmacêutico.INTRODUCTION: The data presented are part of a World Health Organization (WHO multicenter study of self-medication in Latin America. Brazilian sites included: Belo Horizonte, Fortaleza, the city of S. Paulo and outlying locations. The objective was to characterize self-medication practices by analyzing drugs sought by consumers in pharmacies without a physician's prescription. MATERIAL AND METHOD: Drugs were classified according to the Anatomic Therapeutic Classification codes, and analyzed with respect to 1 intrinsic value; 2 recognition as

  15. Bioethical aspects of basic research and medical applications of human stem cells

    Directory of Open Access Journals (Sweden)

    Manuel J Santos

    2012-01-01

    Full Text Available The new discoveries, the extraordinary dynamism in human stem cell (SC research, and the great expectations of the benefits in clinical treatment of many diseases are on the edge of unparalleled advances in both: 1 the understanding of basic mechanisms of cell differentiation and development and 2 the translation from basic research to new clinical therapies. Human stem cells are obtained from different sources, such as embryo, fetal, and adult tissues, in vitro induction (iPS cells or transdifferentiation. The evidence that these cells are pluripotent (or multipotent, meaning they have the ability to differentiate into all body tissues or tissues of the same lineage, raises the possibility that they could regenerate diseased or damaged tissue in diseases that until now have had no effective treatments. Human stem cell research and therapy raise important bioethical considerations because of the human nature of these cells and their peculiar characteristics. Here we discuss the bioethical aspects of basic human SC research and the conditions necessary for the translation of basic preclinical research into clinical use of SC.

  16. Physiological and Medical Aspects That Put Women Soldiers at Increased Risk for Overuse Injuries.

    Science.gov (United States)

    Epstein, Yoram; Fleischmann, Chen; Yanovich, Ran; Heled, Yuval

    2015-11-01

    Anthropometric and physiological factors place female soldiers at a disadvantage relative to male soldiers in most aspects of physical performance. Average aerobic and anaerobic fitness levels are lower in women than in men. Thus, women have a lower overall work capacity and must exert themselves more than men to achieve the same output. The lower weight and fat-free mass and the higher body fat of women are associated with lower muscle strength and endurance, placing them at a disadvantage compared with men in performing military tasks such as lifting and carrying weights, or marching with a load. Working at a higher percentage of their maximal capacity to achieve the same performance levels as men, women tire earlier. Their smaller size, skeletal anatomy, and different bone geometry also predispose women to a higher incidence of exercise-related injuries. Consequently, the attrition rate of female soldiers in combat units is higher than that of their male counterparts. This review summarizes the literature on gender-related physiological and anatomical differences that put female soldiers at an increased risk of exercise-related injuries. PMID:26506172

  17. The physical and physiological aspects of xenon isotopes in nuclear medical applicants

    International Nuclear Information System (INIS)

    A method for trapping radioactive xenon waste from nuclear medical departments has been investigated. Adsorption of xenon acivitaded charcoal was found to be an efficient trapping method. A large gain in capacity was found when the trap was refrigerated, and permitted a large number of patient investigations before break-through of xenon occurred. By heating charcoal traps to 250-350 degrees C, adsorbed xenon gas is freed and is thus made available for re-use. A technique for room-air monitoring of xenon-leakage from patient investigations is described, where the room-air is continously pumped through a small charcoal filter, mounted close to a detector. The low gammaenergy of Xe-133, 81 keV, introduces problems for in vivo measurements due to the small differences in the energies of the primary and Compton-scattered photons. Influence of scatter and of hemispheric cross-talk was studied for cerebral blood-flow measurements. It was shown that substantial artefacts are introduced in the calculation of regional gray matter flow. The applicability of the xenon-washout technique for liver blood-flow measurements in rat was investigated. (author)

  18. Medical aspects of the development of an environmental data base taking into account experience in keeping population related cancer records

    International Nuclear Information System (INIS)

    The paper relates to the medical aspects of the development of an environmental data base taking into account experience in keeping population related cancer records. Information on the data and associated problems for maintaining such data bases of the National Cancer Registry (NRC) of the former GDR are presented. NRC data on cancer occurrence in individuals or groups covers the entire territory of the former GDR; they can be combined with data on occupational or environmental exposure available from other institutions. Information on radiation related health risks in the southern districts (e.g. Saxony) are also available. Data were used for health planning, epidemiological research etc. It is concluded that in collecting data the different items should be classified as core items and optional items with appropriate priority. (author). 9 refs

  19. Regulatory aspects of the medical and occupational exposures in the application of the radiosynoviortesis technique

    International Nuclear Information System (INIS)

    The Radiosynoviortesis is a to therapeutic proceed that consists in the injection of a radiopharmaceutical beta transmitter in the synovial cavity of the articulations affected by arthropaties. With it is achieved to cause the fibrosis and remodeling of the synovial membrane obtaining a remarkable improvement in the patients that it includes the disappearance of the pain and the increase of the flexibility of the treated articulation. The technique began to be carried out from 1952 in Europe when it was injected Au196 in patients affected by rheumatoid arthropaties and starting from then it has gone winning followers in Canada, United States, Australia and some countries of Latin America. Their results are satisfactory and they have been endorsed by the practice. In Cuba it was carried out at November 16, 2002 a clinical essay with the use of this technique, the same one was Graduate by the National Center of Nuclear Safety, in their condition of Regulatory Authority, for it the National Institute of Hematology and Immunology presented the technical documentation that bases its safety. However for the generalization of this technique and their inclusion in the Nuclear Medicine services already existent, the Regulatory Authority has indicated a group of requirements that should be kept in mind in a such way that the application of the Radiosynoviortesis fulfills the Regulation of those 'Basic Norms of Radiological Safety' effective in our country. The present work exposes the particularities and challenges that the Radiosynoviortesis outlines from the point of view of the Radiological Protection, as well as the technical aspects that should be kept in mind for its Licensing, in such way that the is guaranteed safety of the same one in the relative thing to the radiological protection of the patients, those workers and the one publishes. The work reaffirms the feasibility of this to therapeutic proceed from the point of view of the radiological protection, proposing

  20. Important radiation protection aspects of the operation of a commercial medical cyclotron

    International Nuclear Information System (INIS)

    Since July 1991 the Radiopharmaceutical Division of the Australian Nuclear Science and Technology Organisation (ANSTO) operates a 30 MeV H'- ion Medical Cyclotron (Model; CYCLONE 30, Manufacturer: Ion Beam Applications, Louvain La Neuve, Belgium). During routine isotope production operations at the cyclotron a thick copper substrate plate electroplated with thin layer of selected enriched target material are bombarded with 30 MeV proton beam current up to 450 μA. The nuclear reaction of protons with the copper atoms result in the reduction of prompt evaporation neutrons with a peak energy of ∼ 1.8 MeV. These evaporation neutrons slow down via multiple collisions with the concrete shielding walls of the target cave, bounce back to the,interior space of the cave activating the cyclotron parts, beam tube components and other utilities installed in the irradiation cave. After the completion of 60 hour isotope production run, gamma dose equivalent rates of ∼105 μSvh-1 were measured at contact with the target irradiation stations and beam collimators. Evidently, these gamma rays emitted from the activated cyclotron components impose crucial radiation exposure hazard problems for the cyclotron maintenance technicians. Experiments had been carried out in order to identify the specific pathways of cyclotron component activation and to assess the probable personnel radiation exposure during handling of the activated cyclotron parts. The cool-down (radioactive decay) of the activated cyclotron components was estimated experimentally at different target bombardment conditions using the wall mounted gamma area monitors interfaced to the Health Physics Data Acquisition System. The gamma dose equivalent rates at contact with various locations of interest at the target irradiation station and at the typical work areas of the maintenance personnel were carefully recorded with a radiation (gamma) survey instrument during the three years operation period of the cyclotron. A

  1. Research trends in biomimetic medical materials for tissue engineering: 3D bioprinting, surface modification, nano/micro-technology and clinical aspects in tissue engineering of cartilage and bone.

    Science.gov (United States)

    Chen, Cen; Bang, Sumi; Cho, Younghak; Lee, Sahnghoon; Lee, Inseop; Zhang, ShengMin; Noh, Insup

    2016-01-01

    This review discusses about biomimetic medical materials for tissue engineering of bone and cartilage, after previous scientific commentary of the invitation-based, Korea-China joint symposium on biomimetic medical materials, which was held in Seoul, Korea, from October 22 to 26, 2015. The contents of this review were evolved from the presentations of that symposium. Four topics of biomimetic medical materials were discussed from different research groups here: 1) 3D bioprinting medical materials, 2) nano/micro-technology, 3) surface modification of biomaterials for their interactions with cells and 4) clinical aspects of biomaterials for cartilage focusing on cells, scaffolds and cytokines. PMID:27148455

  2. Technical aspects of boron neutron capture therapy at the BNL Medical Research Reactor

    International Nuclear Information System (INIS)

    The Brookhaven Medical Research Reactor, BMRR, is a 3 MW heterogeneous, tank-type, light water cooled and moderated, graphite reflected reactor, which was designed for biomedical studies. Early BNL work in Boron Neutron Capture Therapy (BNCT) used a beam of thermal neutrons for experimental treatment of brain tumors. Research elsewhere and at BNL indicated that higher energy neutrons would be required to treat deep seated brain tumors. Epithermal neutrons would be thermalized as they penetrated the brain and peak thermal neutron flux densities would occur at the depth of brain tumors. One of the two BMRR thermal port shutters was modified in 1988 to include plates of aluminum and aluminum oxide to provide an epithermal port. Lithium carbonate in polyethylene was added in 1991 around the bismuth port to reduce the neutron flux density coming from outside the port. To enhance the epithermal neutron flux density, the two vertical thimbles A-3 (core edge) and E-3 (in core) were replaced with fuel elements. There are now four fuel elements of 190 grams each and 28 fuel elements of 140 grams each for a total of 4.68 kg of 235U in the core. The authors have proposed replacing the epithermal shutter with a fission converter plate shutter. It is estimated that the new shutter would increase the epithermal neutron flux density by a factor of seven and the epithermal/fast neutron ratio by a factor of two. The modifications made to the BMRR in the past few years permit BNCT for brain tumors without the need to reflect scalp and bone flaps. Radiation workers are monitored via a TLD badge and a self-reading dosimeter during each experiment. An early concern was raised about whether workers would be subject to a significant dose rate from working with patients who have been irradiated. The gamma ray doses for the representative key personnel involved in the care of the first 12 patients receiving BNCT are listed. These workers did not receive unusually high exposures

  3. A Ferromagnetic Foreign Body at the Lateral Aspect of the Mandibular Ramus in a Medically Compromised Patient

    Science.gov (United States)

    Yamamoto, K; Nakayama, Y; Yamamoto, I; Matsusue, Y; Shimotsuji, H; Kirita, T

    2016-01-01

    A case of a ferromagnetic foreign body in a medically compromised patient was reported. The patient was a 45-year-old male who consulted our department complaining of a foreign body accidentally impacted in the right cheek. X-ray examination revealed a foreign body at the lateral aspect of the right mandibular ramus. The removal of the foreign body was scheduled, but the patient did not return for the procedure. After 8 years he revisited our department for the removal of the foreign body, because it had been found to be ferromagnetic and a barrier to MRI examination. X-ray examination confirmed the foreign body was located at the same site as 8 years prior. Although the patient was suffering from liver cirrhosis with thrombocytopenia and leukopenia, the foreign body was successfully removed under general anesthesia. The foreign body was 12 × 5 × 1 mm, weighed 0.48 g, and was ferromagnetic. The patient’s postoperative course was uneventful. X-ray examination confirmed the removal of the foreign body. Since the surgery, the patient has been in generally stable condition with no complications. This case was a rare example of a foreign body that needed to be removed for medical examination.

  4. A Review of Supplementary Medical Aspects of Post-Cold War UN Peacekeeping Operations: Trends, Lessons Learned, Courses of Action, and Recommendations.

    Science.gov (United States)

    Johnson, Ralph J

    2015-01-01

    Post-Cold War United Nations Peace Keeping Operations (UN PKOs) have been increasingly involved in dangerous areas with ill-defined boundaries, harsh and remote geographies, simmering internecine armed conflict, and disregard on the part of some local parties for peacekeepers' security and role. In the interest of force protection and optimizing operations, a key component of UN PKOs is healthcare and medical treatment. The expectation is that UN PKO medical support will adjust to the general intent and structure of UN PKOs. To do so requires effective policies and planning informed by a review of all medical aspects of UN PKO operations, including those considered supplementary, that is, less crucial but contributing nonetheless. Medical aspects considered paramount and key to UN PKOs have received relatively thorough treatment elsewhere. The intent of this article is to report on ancillary and supplemental medical aspects practical to post-Cold War UN PKO operations assembled through an iterative inquiry of open-source articles. Recommendations are made about possible courses of action in terms of addressing trends found in such medical aspects of PKOs and relevance of US/NATO/European Union models and research. PMID:26606413

  5. Attitude of Iranian Medical Oncologists Toward Economic Aspects, and Policy-making in Relation to New Cancer Drugs

    Directory of Open Access Journals (Sweden)

    Rajabali Daroudi

    2016-02-01

    Full Text Available Background Although medical oncologists can have an important role in controlling the cost of cancer treatment, there is little information about their attitudes toward the cost of cancer treatment and the impact of cost on their treatment recommendations, especially in low- and middle-income countries (LMICs. In this study, we assessed the attitude of Iranian medical oncologists toward some economic aspects of new cancer drugs. Methods We translated a questionnaire that was used in similar studies in the United States and Canada into Persian and modified it according to the local setting in Iran. The face and content validity of the questionnaire were assessed by oncologists before being used in the survey. We distributed the questionnaire and collected the data from 80 oncologists who participated in the 13th Annual Congress of the Iranian Society of Medical Oncology and Hematology (ISMOH. Results Fifty-two oncologists participated in our study (a response rate of 65%. The majority of oncologists stated that drug costs and patient out-of-pocket (OOP costs influence their treatment recommendations (92% and 94%, respectively. Most oncologists (70% felt that they are ready enough to use cost-effectiveness information in their treatment decisions, and 74% believed that patients should only have access to cancer treatments that are cost-effective. Most oncologists agree that the government should have control over drug prices, and more use of cost‐effectiveness data is required for decision-making about cancer drug coverage. Ninety-one percent of oncologists said that they always or frequently discuss cancer treatment costs with their patients. Oncologists believed that academic groups (research centers and scientific societies (81% and the Ministry of Health (MoH (43% are the most eligible groups for determining whether a drug provides good value. Conclusion Iranian medical oncologists are ready to participate in the health technology assessment

  6. Insulin and carbohydrate dysregulation.

    Science.gov (United States)

    Gelato, Marie C

    2003-04-01

    Patients with human immunodeficiency virus receiving highly active antiretroviral therapy (HAART) may experience abnormal body composition changes as well as metabolic abnormalities, including dyslipidemia, increases in triglycerides, low high-density lipoprotein cholesterol levels, and abnormal carbohydrate metabolism, ranging from insulin resistance with and without glucose intolerance to frank diabetes. Whether the body composition changes (i.e., increased visceral adiposity and fat wasting in the peripheral tissues) are linked to abnormalities in carbohydrate metabolism is unclear. The use of HAART with and without therapy with protease inhibitors (PIs) is related to carbohydrate abnormalities and changes in body composition. Regimens that include PIs appear to have a higher incidence of insulin resistance (up to 90%) and diabetes mellitus (up to 40%). The etiology of these abnormalities is not well understood; what is known about insulin and carbohydrate dysregulation with HAART is discussed. PMID:12652377

  7. Medical Aspects of Lightning

    Science.gov (United States)

    ... useful to have neuropsychological testing for brain injuries. Neuropsychological testing is expensive but may be useful for those who need to document learning or processing disabilities for school or work. Where Can Survivors Get Help? The ...

  8. Demographic, medical and visual aspects of Dia- betic Retinopathy (DR and Diabetic Macular Edema (DME in South African diabetic patients*

    Directory of Open Access Journals (Sweden)

    Anusha Y. Sukha

    2009-12-01

    Full Text Available Objective: To investigate some of the demographic, medical, and visual aspects of diabetic retinopathy (DR and diabetic macula edema (DME in diabetics attending an urban clinic in Johannesburg, Gauteng.Design: In this cross-sectional study, 202 diabetic patients were recruited. Demographic variables included age, gender, race, age of diagnosis, duration of diabetes mellitus (DM, and social habits. Medical variables included systemic conditions present, blood pressures, body mass indices (BMI, lipid profiles, glycerated haemoglobin (HbA1c, and other biochemical data. Visual variables included distance, pinhole and near visual acuities, contrast visual acuities (CVA, refractive status, colour vision, central visual field evaluation with the Amsler grid, intraocular pressures (IOP, fundus photography and administration of the Impact of Visual Impairment (IVI questionnaire. All variables were compared between diabetic subjects with and with-out DR and DME in both right and left eyes.Results: Overall prevalence of DR was 22.8% and DME 12.5%. In DR subjects, significant results indicated that Whites were more likely to present with DR (p = 0.002. Subjects with DR had a higher mean duration of DM (p = 0.002 and a higher mean diastolic blood pressure (p = 0.035. Autorefraction suggested that more myopia and less astigmatism might be associated with DR. A higher mean CVA at the 2.5% level in DR was significant in both the right eyes (p = 0.042 and left eyes (p = 0.035. These subjects also reported a higher mean IVI score in the consumer and social interaction domain (p = 0.032. Similarly, DME subjects displayed a higher mean duration of DM (p = 0.042 and a higher mean diastolic blood pressure (p = 0.048. A higher mean CVA was associated at both the 10% level: right eyes (p = 0.021; and left eyes (p = 0.046, and at the 2.5% level: right eyes (p = 0.033 and left eyes (p = 0.045. A higher mean IVI score in leisure and work (p = 0.026, consumer and social

  9. Patients' attitudes to medical and psychosocial aspects of care in fertility clinics: Findings from the Copenhagen Multi-centre Psychosocial Infertility (COMPI) Research Programme

    DEFF Research Database (Denmark)

    Schmidt, L; Holstein, B E; Boivin, J; Sångren, H; Tjørnhøj-Thomsen, T; Blaabjerg, J; Hald, F; Andersen, A Nyboe; Rasmussen, P E

    2003-01-01

    services for both men and women was high infertility-related stress in the marital, personal and social domain. CONCLUSIONS: A supportive attitude from medical staff and the provision of both medical and psychosocial information and support should be integral aspects of medical care in fertility clinics......BACKGROUND: The aims were (i) to identify gender differences in motivations to seek assisted reproduction and gender differences in expectations about medical and psychosocial services and (ii) to examine factors that predict the perceived importance of, and intention to use, psychosocial services...... among infertile people. METHODS: We conducted an epidemiological study based on questionnaires among all new couples attending five fertility clinics with a response rate of 80.0% and a total of 2250 patients. RESULTS: The vast majority of both men and women considered a high level of medical...

  10. Total body irradiation for bone marrow graft. Results of a national survey on protocols and conditions of their application. Part I: medical and logistic aspects

    International Nuclear Information System (INIS)

    A survey conducted during 1986 evaluated medical and logistic aspects of total body irradiation for bone marrow graft, with particular analysis of type of protocol and functional consequences. Current tendencies were determined by comparison of findings with those of a survey conducted within the framework of the GEGMO in 1984

  11. Diarrhea caused by carbohydrate malabsorption.

    Science.gov (United States)

    Hammer, Heinz F; Hammer, Johann

    2012-09-01

    This article will focus on the role of the colon in the pathogenesis of diarrhea in carbohydrate malabsorption or physiologically incomplete absorption of carbohydrates, and on the most common manifestation of carbohydrate malabsorption, lactose malabsorption. In addition, incomplete fructose absorption, the role of carbohydrate malabsorption in other malabsorptive diseases, and congenital defects that lead to malabsorption will be covered. The article concludes with a section on diagnostic tools to evaluate carbohydrate malabsorption. PMID:22917167

  12. Post-graduated course 'Basic aspects of medical physics in nuclear medicine': theoretical/practical intensive version: preliminary results

    International Nuclear Information System (INIS)

    Full text: Using national and international recommendation about human resource in nuclear medicine, a group of experts organized a national course for the education and training of physicist who works in Cuban hospital, adapted to national condition and practice of nuclear medicine. The program was approved for National Authorities in Nuclear Security and University School in Medicine and content three intensive theoretic and practical courses (15 days of full time duration each), complemented with 4 months full time in Nuclear Medicine Service monitored by accredited expert and 2 months at distance with practical task. The theoretical/practical intensive courses have final evaluation: combining practical exercise and write final test. When all docent activities finish the students should pass a final evaluation by a testing board composed for (at least) three accredited experts. The first theoretical/practical course included 19 physicists who work in hospital, the second 17 and the third 16 students. With 100 point of maximum score and 60 point minimum to pass, the partial final tests included: true or false choice (with 10 aspects to verify, 1 point/correct answer) and questions to write developed answer. The average result was 83.02 points/ students (range 65-100 points). The students evaluated satisfactory the quality of different courses (in anonymous poll), reporting like very good; the quality of conferences, excellent; the usefulness of different charters, very good; the support bibliography, and recommended the repetition of this kind of education and training in order to warranty the human resource, in the same way and content, and included others item in the future. Conclusion: the theoretical/practice intensive courses of this post-graduated course were successful and satisfied the objective of education and training of medical physicist in nuclear medicine. (author)

  13. Development of an informative system on aspects of radiological protection in the medical practices; Desarrollo de un sistema informativo sobre aspectos de proteccion radiologica en las practicas medicas

    Energy Technology Data Exchange (ETDEWEB)

    Lopez B, G.M.; Martinez G, A.; Gonzalez R, N.; Hernandez A, R.; Valdes R, M.; Cardenas H, J.; Zaldivar H, W. [CPHR, Calle 20 No. 4113 e/41 y 47, Playa C.P. 11300 La Habana (Cuba); Diaz B, M.; Machado T, A. [Centro Nacional de Seguridad Nuclear, Ciudad de la Habana (Cuba)]. e-mail: gladys@cphr.edu.cu

    2006-07-01

    Today in day is difficult to imagine the development of the medical practices in the diagnosis and treatment of diverse illnesses without the use of the ionizing radiations. In spite of the diffusion and application of these practices, the patients and the public in general don't have full conscience of like the procedures are carried out and the risks that these involve. For it diverse international and national organizations in the last years recommend to include in the programs of radiological protection, all the information that should be given to the patients and the one public that attend as users to the medical institutions to undergo to procedures that imply the use of the ionizing radiations. In Cuba a growing and quick tendency exists to the introduction of nuclear techniques for medical ends, however paradoxically the relative aspects to the communication to the patients and the public in general about the risks of the procedures to that they will be subjected and in consequence on the measures to minimize them is not adequate. Keeping in mind the above-mentioned, specialists of national centers linked to the control and consultant ship in the topics of radiological protection in the medical practices that use ionizing radiations, they worked in the country in the design of an information system that should contribute to elevate the population's culture before the mentioned aspects. The present work describes the structure of this system in function of the different medical attention levels of our national health system. Additionally it exposes the development of a package of varied informative and training tools among those that are folding, posters, guides, instructions, CD Show that its approach general and specific aspects of the uses and risks of medical practices in nuclear medicine, radiodiagnostic and radiotherapy directed so much to health professionals, patients as public in general. (Author)

  14. Preliminary results and prospects for research performed by the scientists of Ministry of Health of Ukraine on Chernobyl accident medical aspects

    International Nuclear Information System (INIS)

    Results of scientific management of Ministry of Health of Ukraine, as well as scientific researches of 23 scientific research institutes, 11 medical institutes, 6 scientific practical establishment were analyzed to cover Complex ecological research programme on Chernobyl accident outcomes for 1986-1990 (medical aspects). The data about the health of communities, epidemiology, peculiarities of the course, clinical features, diagnosis, treatment and prevention of inner organs and systems disorders and diseases in the exposed persons, which were obtained on the basis of environment radiologic are reported

  15. Carbohydrates and dietary fiber.

    Science.gov (United States)

    Suter, P M

    2005-01-01

    The most widely spread eating habit is characterized by a reduced intake of dietary fiber, an increased intake of simple sugars, a high intake of refined grain products, an altered fat composition of the diet, and a dietary pattern characterized by a high glycemic load, an increased body weight and reduced physical activity. In this chapter the effects of this eating pattern on disease risk will be outlined. There are no epidemiological studies showing that the increase of glucose, fructose or sucrose intake is directly and independently associated with an increased risk of atherosclerosis or coronary heart disease (CHD). On the other hand a large number of studies has reported a reduction of fatal and non-fatal CHD events as a function of the intake of complex carbohydrates--respectively 'dietary fiber' or selected fiber-rich food (e.g., whole grain cereals). It seems that eating too much 'fast' carbohydrate [i.e., carbohydrates with a high glycemic index (GI)] may have deleterious long-term consequences. Indeed the last decades have shown that a low fat (and consecutively high carbohydrate) diet alone is not the best strategy to combat modern diseases including atherosclerosis. Quantity and quality issues in carbohydrate nutrient content are as important as they are for fat. Multiple lines of evidence suggest that for cardiovascular disease prevention a high sugar intake should be avoided. There is growing evidence of the high impact of dietary fiber and foods with a low GI on single risk factors (e.g., lipid pattern, diabetes, inflammation, endothelial function etc.) as well as also the development of the endpoints of atherosclerosis especially CHD. PMID:16596802

  16. MEDICAL AND LITERARY ASPECTS OF THE HISTORY OF THE FILARIASIS BY Wuchereria Bancrofti IN CARTAGENA AND COLOMBIA

    OpenAIRE

    Sotomayor-Tribin Hugo Armando

    2014-01-01

    Description exists in the Colombian medical words of a disease that had high prevalence in Cartagena de Indias, Colombia, since the 16th century until half of the 20th century. The filariasis by Wuchereria bancrofti due to the impacting clinical symptoms that it caused, it was thoroughly described and considered. Medical documents and travel chronicles describe to the patients and the personal and social impacts of the disease, just like the measures that were applied. They wer...

  17. [Carbohydrates and fiber].

    Science.gov (United States)

    Lajolo, F M; de Menezes, E W; Filisetti-Cozzi, T M

    1988-09-01

    Dietary carbohydrates comprise two fractions that may be classified as digestible, and which are useful as energy sources (simple and complex carbohydrates) and fiber, which is presumed to be of no use to the human body. There are insufficient epidemiologic data on the metabolic effects of simple carbohydrates and it is not advisable to make quantitative recommendations of intake. It is questionable to recommend in developing countries that a fixed proportion of dietary energy be derived from simple sugars, due to the high prevalence of deficient energy intake, cultural habits, and regional differences in food intake and physical activity. In relation to recommendations of complex carbohydrates, it should be considered that their absorption is influenced by many factors inherent to the individual and to the foods. Fiber is defined as a series of different substances derived from tissue structures, cellular residues and undigested chemical substances that may be partially utilized after intestinal bacteria have acted on them. There is not a clear definition of the chemical composition of fiber, but it consists mainly of polysaccharides (such as cellulose, hemicellulose and pectins), lignin and end products of the interactions of various food components. The effects of fiber, such as control of food intake, regulation of gastrointestinal transit, post-prandial blood concentrations of cholesterol, glucose and insulin, flatulence and alterations in nutrient bioavailability are due to various physical properties inherent to its chemical components. Impairment of nutrient absorption may be harmful, mainly among populations whose food intake is lower than their energy needs, and with a high fiber content. This may be particularly important in pregnant women, growing children and the elderly, and should be considered when making nutrient recommendations. A precise knowledge of fiber is also important to calculate the real energy value of foods, mainly for two reasons: 1

  18. An Internet-based exercise as a component of an overall training program addressing medical aspects of radiation emergency management.

    Science.gov (United States)

    Levy, K; Aghababian, R V; Hirsch, E F; Screnci, D; Boshyan, A; Ricks, R C; Samiei, M

    2000-01-01

    The use of ionizing radiation and radioactive materials continues to increase worldwide in industry, medicine, agriculture, research, electrical power generation, and nuclear weaponry. The risk of terrorism using weapons of mass destruction or simple radiological devices also has increased, leading to heightened concerns. Radiation accidents occur as a consequence of errors in transportation of radionuclides, use of radiation in medical diagnosis and therapy, industrial monitoring and sterilization procedures, and rarely, nuclear power generation. Compared to other industries, a small number of serious radiation accidents have occurred over the last six decades with recent cases in the Republic of Georgia, Peru, Japan, and Thailand. The medical, psychological, and political consequences of such accidents can be considerable. A number of programs designed to train medical responders in the techniques of radiation accident management have been developed and delivered in many countries. The low frequency of serious radiation accidents requires constant re-training, as skills are lost and medical staff turnover occurs. Not all of the training involves drills or exercises in which responders demonstrate learning or communication over the broad spectrum of medical response capabilities. Medical preparedness within the context of a total emergency response program is lacking in many parts of the world, particularly in Central and Eastern Europe and the Newly Independent States. This paper describes an effort to enhance medical preparedness in the context of a total program of international cooperation and conventions facilitated by the International Atomic Energy Agency. The paper concludes that novel application of telecommunications technology as part of a training activity in radiation accident preparedness can help address gaps in training in this field in which preparedness is essential but experience and practical field exercises are lacking. PMID:11183457

  19. Aspects of Spirituality in Medical Doctors and Their Relation to Specific Views of Illness and Dealing with Their Patients' Individual Situation

    Directory of Open Access Journals (Sweden)

    Arndt Büssing

    2013-01-01

    Full Text Available We intended to analyse which aspects of spirituality are of relevance for medical doctors in a mostly secular society and how their spiritual/religious attitudes are related to specific views of illness, their dealing with patients' individual situation, and finally physicians' life satisfaction. Data from an anonymous survey enrolling 237 medical doctors from Germany (mean age 45.7 ± 9.6, 58% male, 42% female indicated that secular forms of spirituality scored highest, while specific religious orientation had the lowest scores. Physicians with a specific specialization in complementary/alternative medicine (CAM or anthroposophic medicine differed from their conventional counterparts with respect to specific aspects of spirituality; however, the specific views associated with these specialisations were only weakly to moderately correlated with physicians' view on the meaning of illness and how they assume that they would deal with their patients' individual situation. Of interest, the specific aspects of spirituality were negatively correlated with the view of “illness as a meaningless interruption” of life, indicating that physicians with a spiritual attitude would see illness also as a chance for an “individual development” and associated with a “biographical meaning” rather than just a “useless interruption” of life.

  20. Effects of Carbohydrate Consumption Case Study: carbohydrates in Bread

    Directory of Open Access Journals (Sweden)

    Neacsu N.A.

    2014-12-01

    Full Text Available Carbohydrates perform numerous roles in living organisms; they are an important source of energy. The body uses carbohydrates to make glucose which is the fuel that gives it energy and helps keep everything going. However, excess carbohydrate consumption has negative health effects. Bread is a basic product in our nutrition and it also is a product with a high content of carbohydrates. So, it is important to find out more information on bread and on the recommended bread type best for consumption.

  1. Integration geschlechtersensibler Aspekte in die medizinische Lehre - Status Quo und Zukunftsperspektiven [Integration of gender-specific aspects into medical curricula - status quo und future perspectives

    Directory of Open Access Journals (Sweden)

    Pfleiderer, Bettina

    2012-11-01

    Full Text Available [english] The consideration of gender aspects in clinical routine is of high importance towards an individualized patient care and a starting point of diversity medicine. Gender-specific awareness is an indispensable basis for an optimized medical treatment. A current study at the medical faculties of Muenster and Duisburg-Essen University (Germany revealed an insufficient knowledge among students and lecturers in this area. An interdisciplinary, international workshop took place in Muenster (Germany in May 2012 on the topic how to integrate gender aspects into medical curricula in the future aiming at a better health care for both sexes in long term. This position paper summarizes the conclusions. It was suggested to teach gender-specific contents from the first semester comprehensively – using standardized definitions and a gender-neutral language, since it is crucial not to increase the students’ workload any further. The key to success is to implement gender aspects by using meaningful examples on a regular basis – ideally in a longitudinal manner. The content of teaching should be selected by the lecturers and full professors and be considered within students´ exams. To reach these goals, an absolute support of the respective medical faculties as well as the integration of these gender-specific learning objectives into the national competence-based learning catalogue for medical education (NKLM is obligatory.[german] Die Berücksichtigung von Geschlechteraspekten im klinischen Alltag ist ein wichtiger Schritt auf dem Weg zu passgenauer Medizin und der Beginn einer.Kenntnisse über geschlechtersensible Aspekte in der Medizin sind eine essentielle Grundlage für eine optimale PatientInnenversorgung. Diese Kompetenz ist sowohl unter Studierenden als auch Lehrenden unzureichend vorhanden - wie eine aktuelle Studie der Universitäten Münster und Duisburg-Essen belegt. Am 30./31. Mai 2012 fand in Münster ein internationaler

  2. Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects

    Directory of Open Access Journals (Sweden)

    Bocci Velio

    2011-04-01

    Full Text Available Abstract Besides oxygen, several other gases such as NO, CO, H2, H2S, Xe and O3 have come to age over the past few years. With regards to O3, its mechanisms of action in medicine have been clarified during the last two decades so that now a comprehensive framework for understanding and recommending ozone therapy in various pathologies is available. O3 used within the determined therapeutic window is absolutely safe and more effective than golden standard medications in numerous pathologies, like vascular diseases. However, ozone therapy is mostly in practitioners' hands and some recent developments for increasing cost effectiveness and speed of treatment are neither standardized, nor evaluated toxicologically. Hence, the aim of this article is to emphasize the need to objectively assess the pros and cons of oxygen/ozone as a medical gas mixture in the hope that ozone therapy will be accepted by orthodox medicine in the near future.

  3. Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects

    Science.gov (United States)

    2011-01-01

    Besides oxygen, several other gases such as NO, CO, H2, H2S, Xe and O3 have come to age over the past few years. With regards to O3, its mechanisms of action in medicine have been clarified during the last two decades so that now a comprehensive framework for understanding and recommending ozone therapy in various pathologies is available. O3 used within the determined therapeutic window is absolutely safe and more effective than golden standard medications in numerous pathologies, like vascular diseases. However, ozone therapy is mostly in practitioners' hands and some recent developments for increasing cost effectiveness and speed of treatment are neither standardized, nor evaluated toxicologically. Hence, the aim of this article is to emphasize the need to objectively assess the pros and cons of oxygen/ozone as a medical gas mixture in the hope that ozone therapy will be accepted by orthodox medicine in the near future. PMID:22146387

  4. Ethico-legal aspects of hospital-based blood transfusion practice; implications of professional negligence to medical practitioners: a review

    Directory of Open Access Journals (Sweden)

    Orkuma J.A

    2014-12-01

    Full Text Available Background: Blood transfusion is predominantly a hospital-based practice in many resourceconstrained economies like Nigeria, wherein the sourcing, storage, processing and clinical use of blood and blood products resides in the often financial and manpower constrained hospitals. Aim: To identify the ethical and legal issues related to hospital-based blood transfusion practice for medical practitioner. Methods: Relevant articles retrieved via PubMed/MEDLINE and Google scholar search engines were used. Results: This review found that, medical practitioners are directly or vicariously liable in professional negligence in hospital-based transfusion injuries. The potential weaknesses in hospital-based blood transfusion practice as ethically identified include; transfusion transmissible infections, blood group incompatibility, haemolytic transfusion reaction, failure to obtain informed consent and challenges of haemovigillance. However from the cases considered, medical practitioners are more professionally liable where they withhold a transfusion or transfuse blood group incompatible transfusion or fail to obtain an informed consent for blood transfusion especially amongst Jehovah’s Witness adherents. Conclusion: Medical practitioners at hospital-based transfusion centres are professionally liable for negligence due to blood transfusion injuries by their clinical, laboratory or general administrative oversight at different levels of hospital management. It is recommended that, they carry out this duty cautiously. While error reporting should be encouraged, litigations against them should be pursued cautiously in order not to encourage defensive blood transfusion practices in fear of claims or litigations to the disadvantage of the patients. Mediation or arbitration systems which are faster, less expensive and often less punitive but help strengthen the blood transfusion services should be encouraged.

  5. SCIENTIFIC AND HISTORICAL ASPECTS OF RADIATION HYGIENE TRAINING IN THE MILITARY MEDICAL ACADEMY AFTER S.M. KIROV

    Directory of Open Access Journals (Sweden)

    V. V. Omelchuk

    2013-01-01

    Full Text Available An article presents materials describing the historical stages of the development of radiation hygiene training in the Military Medical Academy after S.M. Kirov. Particular attention is paid to the development of scientific, methodological and pedagogical potential of the staff of naval and radiation hygiene department. The main achievements of doctoral and teaching staff in the radiation hygiene training are presented.

  6. MEDICAL AND LITERARY ASPECTS OF THE HISTORY OF THE FILARIASIS BY Wuchereria Bancrofti IN CARTAGENA AND COLOMBIA

    Directory of Open Access Journals (Sweden)

    Sotomayor-Tribin Hugo Armando

    2014-06-01

    Full Text Available Description exists in the Colombian medical words of a disease that had high prevalence in Cartagena de Indias, Colombia, since the 16th century until half of the 20th century. The filariasis by Wuchereria bancrofti due to the impacting clinical symptoms that it caused, it was thoroughly described and considered. Medical documents and travel chronicles describe to the patients and the personal and social impacts of the disease, just like the measures that were applied. They were extrapolated to the literature, especially for Gabriel García Márquez, who recreates the disease in three of his works. With own strategies of the medicine and European surgery of the epoch, as well as the contributions and indigenous traditions, it was approached for many years in Cartagena de Indias. In the Colombian medical words of the 19th and 20th century, the approach and the clinical and therapeutic considerations that were realized for then could be observed just like the increasing borders between the empiricism and the nascent etiological scientific treatment. Rev.cienc.biomed. 2014;5(2: 374-381. KEYWORDS History of medicine, Filarial elephantiasis, Wuchereria bancrofti.

  7. Impact of Dietary Carbohydrate and Protein Levels on Carbohydrate Metabolism

    Science.gov (United States)

    Lasker, Denise Ann

    2009-01-01

    The goal of this dissertation was to investigate the impact of changing dietary carbohydrate (CARB) intakes within recommended dietary guidelines on metabolic outcomes specifically associated with glycemic regulations and carbohydrate metabolism. This research utilized both human and animal studies to examine changes in metabolism across a wide…

  8. Dietary carbohydrates and endurance exercise.

    Science.gov (United States)

    Evans, W J; Hughes, V A

    1985-05-01

    Antecedent diet can greatly influence both substrate utilization during exercise and exercise performance itself. A number of studies have convincingly demonstrated that short-term (three to seven days) adaptation to a low carbohydrate diet results in greatly reduced liver and muscle glycogen stores. While carbohydrate utilization after such a diet is reduced, the limited glycogen stores can severely limit endurance exercise performance. High carbohydrate diets on the other hand expand carbohydrate stores which can limit performance. However, long-term adaptation to a low carbohydrate diet can greatly alter muscle and whole body energy metabolism to drastically limit the oxidation of limited carbohydrate stores with no adverse effect on performance. Glycogen loading techniques can result in supercompensation of muscle stores. Exercise induced depletion of muscle glycogen is the most important single factor in this phenomenon. Following the exercise a low carbohydrate diet for two to three days after which a high carbohydrate diet is eaten seemingly has the same effect on increasing muscle glycogen stores as simply eating a high carbohydrate diet. The form of the dietary carbohydrate during glycogen loading should be high in complex carbohydrates; however, the type of dietary starch that effects the greatest rate of resynthesis has not been investigated. Rapid resynthesis of glycogen following exercise is at least in part due to increased insulin sensitivity. The enhanced glucose transport caused by the increased sensitivity provides substrate for glycogen synthase. How rapidly this enhanced sensitivity returns to pre-exercise levels in humans is uncertain.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3993621

  9. [Modern aspects of combat maxillofacial trauma (review of foreign scientific-medical publications during 2012-2013)].

    Science.gov (United States)

    Grebnev, G A; Bolekhan, V N; Golota, A S; Ivchenko, E V; Krassiĭ, A B; Nagibovich, O A; Parfenov, V D; Rezvantsev, M V

    2013-04-01

    The current article is dedicated to the modern aspects of combat maxillofacial trauma as they have been presented in 2012-2013 scientific publications. It has been shown that due to employment of more and more powerful explosive devices the facial trauma over the last decade has occurred more frequently and become more severe. Some new methods of facial injuries treatment are being tested now, among them KSL-W antimicrobial decapeptide, new bone regenerative biocompatible materials, scar-healing mesenchymal and adipose-derived stem cells, and a custom automated face dressing platform. PMID:24000612

  10. Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects

    OpenAIRE

    Bocci Velio; Zanardi Iacopo; Travagli Valter

    2011-01-01

    Abstract Besides oxygen, several other gases such as NO, CO, H2, H2S, Xe and O3 have come to age over the past few years. With regards to O3, its mechanisms of action in medicine have been clarified during the last two decades so that now a comprehensive framework for understanding and recommending ozone therapy in various pathologies is available. O3 used within the determined therapeutic window is absolutely safe and more effective than golden standard medications in numerous pathologies, l...

  11. Ethical and legal aspects of medical exposure to ionizing radiation in the Netherlands in the year 2000

    International Nuclear Information System (INIS)

    In ancient times in Greece lived a very wise man. He told physicians; when you treat patients be aware you will 'do good and no harm'. From this specific point of view I kindly ask attention for legal and ethical dimensions of medical exposures of ionizing radiation. This paper gives first a resume of the basic safety standards for radiation protection. Second it gives the legal instruments a patient in the Netherlands has to exercise his right of self-determination. Third, it pays attention to a basic ethical norm for professional attitude. And finally, it brings forward a guideline for self regulation by professionals. (author)

  12. Carbohydrates and Diabetes (For Parents)

    Science.gov (United States)

    ... of diet foods. These foods may contain extra sugar as a substitute for fat calories. Try to include your child or teen as you evaluate and select healthy carbohydrate-containing foods. With ... blood sugar. By taking a smart approach to balancing carbohydrates, ...

  13. Catalytic Conversion of Carbohydrates

    DEFF Research Database (Denmark)

    Osmundsen, Christian Mårup

    a renewable route to aromatics. The conversion of biomass by high temperature processes is a desirable prospect due to the high volumetric production rates which can be achieved, and the ability of these types of processes to convert a wide range of substrates. Current processes however typically...... process could prove to be an efficient initial conversion step in the utilization of biomass for chemicals production. The shift from an oil based chemical industry to one based on renewable resources is bound to happen sooner or later, however the environmental problems associated with the burning of...... production of commodity chemicals from the most abundantly available renewable source of carbon, carbohydrates. The production of alkyl lactates by the Lewis acid catalyzed conversion of hexoses is an interesting alternative to current fermentation based processes. A range of stannosilicates were...

  14. General aspects of meteorology and wind flow patterns at the National Medical Cyclotron site, Camperdown, NSW, Australia

    International Nuclear Information System (INIS)

    As part of an assessment into the consequences of a potential accident at the National Medical Cyclotron, Camperdown, NSW., Australia, two meteorological stations were installed to monitor the winds, temperatures and atmospheric dispersion conditions. The data will be used to assess environmental impacts of the Cyclotron's operation. In spite of the relatively poor performance of the stations, the wind data indicated significant effects of local buildings and the general urban surface roughness features. The prevailing winds during the study were from the north-north-west at night and south-south-west or north-east sea breezes during the day. Atmospheric stability/dispersion categories were typical of an urban heat island location. 11 refs., 10 tabs, 6 figs

  15. Medical and Dental Guidance Notes. A Good Practice Guide on all Aspects of Ionising Radiation Protection in the Clinical Environment

    International Nuclear Information System (INIS)

    Institute of Physics and Engineering in Medicine York: IPEM 225 pp, ISBN: 1-903613-09-4. This book is the much awaited replacement for the old yellow 'Guidance Notes' published in 1988 by the National Radiological Protection Board (NRPB). Since then nearly all Regulations covering the use of ionising radiation have been updated. The Institute of Physics and Engineering in Medicine (IPEM) established a working group in 1999 to produce a first draft for consultation (produced in April 2000) and to consider subsequent comments to this draft. The final document, published by IPEM, is therefore the end product of numerous contributions from professionals working in healthcare and wide consultation with professional bodies, the NRPB, UK Health Departments, Environment Agencies and the HSE. The notes provide general guidance on good practice - not just legal requirements. Radiation Protection Advisers and Medical Physics Experts may well have instigated slightly different arrangements locally. The publication has been available in electronic form on the IPEM website ( www.ipem.org.uk/publications/IRR99.html) for a few months. This has been useful for quick access to advice and for searching for particular topics but is difficult to read in large sections. Although it can be downloaded, the main documented is protected so that it can not be printed and specific text can not be 'cut and pasted'. The appendices are in a separate file that can be printed. Although the chapter paragraph numbers are consistent between the electronic and papers versions, the page numbers are different. The new guidance is ring bound, so, apart from at the beginning and end of the book, it is generally easy to open it out and lay it flat. The book consists of 19 chapters and 21 appendices and, with 225 pages, is considerably more extensive than the old notes. It begins with the general measures for radiation protection followed by radiation protection of persons undergoing medical exposures

  16. Indoor air pollution. Chemical, physiological, hygienic, medical and toxicological aspects; Innenraum-Luftverunreinigungen. Chemie, Physiologie, Hygiene, Medizin und Toxikologie

    Energy Technology Data Exchange (ETDEWEB)

    Botzenhart, K.; Mueller, H.E.; Strubelt, O.

    2001-07-01

    The book starts by presenting the fundamentals of indoor air hygiene with all relevant chemical, physical and physiological data, standards, criteria of comfort and tolerance levels. Indoor air pollutants are combustion products, volatile organic substances, dust, fibres, radon and bio-aerosols. They are analyzed toxicologically in consideration of the dose/time effect principle and of NOEL, ADI, immission MIC and MPC levels. The somatic and psychosomatic reactions that can be defined in medical terms are described, and the complex symptoms of SBS are derived from them. SBS is a phenomenon with serious consequences: Either the building must be modified to ensure more wholesome living and working conditions, or else the inhabitants need psychological consulting. [German] Das Buch behandelt zunaechst die Grundlagen der Luft- und Wohnungshygiene mit ihren relevanten chemischen, physikalischen und physiologischen Kenndaten, Normwerten, Behaglichkeitskriterien und Toleranzschwellen. Schadstoffe in Innenraeumen sind Verbrennungsprodukte, fluechtige organische Verbindungen sowie Staeube, Fasern, Radon und Bioaerosole. Sie werden toxikologisch unter Beruecksichtigung des Dosis-Zeit-Wirkungsprinzips sowie von NOEL, ADI-, Immissions-, MIK- und MAK-Werten beurteilt. Die medizinisch fassbaren somatischen und psychosomatischen Reaktionen werden beschrieben und daraus die komplexe Symptomatik des SBS abgeleitet. Es macht entweder eine Gebaeudesanierung notwendig oder die psychologische Betreuung der Betroffenen. (orig.)

  17. Improving mining technology and organization of labor in the light of medical-biological aspects of physical health of miners

    Energy Technology Data Exchange (ETDEWEB)

    Egorov, P.V.; Nirenburg, K.G.; Davydova, N.N.; Dyatlova, L.A. (Kuzbasskii Politekhnicheskii Institut (USSR))

    1991-12-01

    Transfer to a contract-bonus system in mines of the Severokuzbassugol' and Leninskugol' associations (USSR) increased coal mining productivity by 42.2-54.4%, but, at the same time, problems concerning miners' health were noted. Presents data on the productivity and labor conditions of contract teams working at coal mining and in development faces. The influence of noise and vibration induced stresses on organisms of underground workers is analyzed. Investigations showed that 3 stages of exhaustion are likely to develop and that the most vulnerable are the cardiovascular system and the respiratory tract. The 3 stages of exhaustion and ability to recover were studied on mining machine operators and drivers of heading machines. Data showed that during the 1985-89 period, 972 miners received disability certificates; the rate of disability was 2.6 miners per 1 Mt of coal; 40.5% of miners over 40 years working on labor-intensive jobs had three or more chronic diseases which could cause permanent disability. In the structure of disability, cardio-vascular system cases accounted for 25%, osseous-muscular system cases for 20% and pulmonary diseases for 13%. Stresses the need for every mine to maintain its own medical center equipped with inhalation therapy, psychological relief, acupuncture and physiotherapy facilities.

  18. Very low-carbohydrate diets in the management of diabetes revisited.

    Science.gov (United States)

    Schofield, Grant Martin; Henderson, George; Thornley, Simon

    2016-01-01

    Humans can derive energy from carbohydrate, fat, or protein. The metabolism of carbohydrate requires by far the highest secretion of insulin. The central pathology of diabetes is the inability to maintain euglycaemia because of a deficiency in either the action or secretion of insulin. That is, because of either insulin resistance often accompanied by hyperinsulinaemia, or insulin deficiency caused by pancreatic beta cell failure. In individuals dependent on insulin and other hypoglycaemic medication, the difficulty of matching higher intakes of carbohydrates with the higher doses of medication required to maintain euglycaemia increases the risk of adverse events, including potentially fatal hypoglycaemic episodes. Thus, mechanistically it has always made sense to restrict carbohydrate (defined as sugar and starch, but not soluble and insoluble fibre) in the diets of people with diabetes. Randomised clinical trials have confirmed that this action based on first principles is effective. The continued recommendation of higher-carbohydrate, fat-restricted diets has been criticised by some scientists, practitioners and patients. Such protocols when compared with very low-carbohydrate diets provide inferior glycaemic control, and their introduction and subsequent increase in carbohydrate allowances has never been based on strong evidence. The trend towards highercarbohydrate diets for people with diabetes may have played a part in the modern characterisation of type 2 diabetes as a chronic condition with a progressive requirement for multiple medications. Here we will introduce some of the evidence for very low-carbohydrate diets in diabetes management and discuss some of the common objections to their use. PMID:27356254

  19. Transition metals in carbohydrate chemistry

    DEFF Research Database (Denmark)

    Madsen, Robert

    1997-01-01

    This review describes the application of transition metal mediated reactions in carbohydrate synthesis. The different metal mediated transformations are divided into reaction types and illustrated by various examples on monosaccharide derivatives. Carbon-carbon bond forming reactions are further ...

  20. Carbohydrates, Sugar, and Your Child

    Science.gov (United States)

    ... are: simple carbohydrates (or simple sugars): these include fructose, glucose, and lactose, which also are found in nutritious ... look at the ingredient list for sugar, corn syrup or sweetener, dextrose, fructose, honey, or molasses, to name just a few. ...

  1. Medical and biological aspects of the Chernobyl nuclear accident influence on the population of the Republic of Moldova

    International Nuclear Information System (INIS)

    Complete text of publication follows. Stress factors action on the population health evaluation, especially on the emergency workers remains one of the most important problems of the contemporary medicine. In this line the Chernobyl nuclear accident (CNA) that took place on the 26th April 1986 at the Chernobyl nuclear power station (NPS) is an eloquent example. Radioactive substances produced in the result of CNA fell out in a significant part of the Europe, including the Republic of Moldova territory, affecting more than 5,000,000 persons. In CNA consequences liquidation participated a lot of military staff including a great number of reservists. Lack of previous experience in the field (it was the first large-scale nuclear accident) made it impossible to prepare specially trained personnel for CNA limitation and liquidation. Consequently a lot of military staff even from the first days presented to medical authorities with a gamma of symptoms, which were henceforth characterized as somatic diseases after detailed investigations. Ionizing radiation influence on the health status of the participants in diminishing of consequences of the Chernobyl nuclear accident (PDCCNA) evaluation is difficult enough and so calls for an ample multilateral study applying modern diagnostic techniques. Large studies were yet conducted in the Russian Federation, the Ukraine and the Republic of Belarus. Acquired data suggests the existence of noticeable deteriorating effect of ionizing radiation produced secondary to CNA with the increased incidence of health status disturbances in affected population. Approximately 3500 inhabitants from the Republic of Moldova took part in the Chernobyl nuclear accident consequences liquidation. Study objective comprises the determination of clinical, immunological and cytogenetic features in PDCCNA from the Republic of Moldova and their descendants. Between 1996 and 2005 period 850 patients - participants in removal of consequences of Chernobyl

  2. Medical and biological aspects of the Chernobyl nuclear accident influence on the population of the Republic of Moldova

    International Nuclear Information System (INIS)

    Complete test of publication follows. Stress factors action on the population health evaluation, especially on the emergency workers remains on e of the most important problems of the contemporary medicine. In this line the Chernobyl nuclear accident (CNA) that look place on the 26th April 1986 at the Chernobyl Nuclear Power Station (CNPS) is an eloquent example. Radioactive substances produced in the result of CNA fell out in a significant part of the Europe, including the Republic of Moldova territory, affecting more than 5,000,000 persons. In CNA consequences liquidation participated a lot of military staff including a great number of reservists. Lack of previous experience in the field (it was the first large-scale nuclear accident) made it impossible to prepare specially trained personnel for CNA limitation and liquidation. Consequently a lot of military staff even from the first days presented to medical authorities with a gamma of symptoms, which were henceforth characterized as somatic diseases after detailed investigations. Ionizing radiation influence on the health status of the participants in diminishing of consequences of the Chernobyl nuclear accident (PDCCNA) evaluation is difficult enough and so calls for an ample multilateral study applying modern diagnostic techniques. Large studies were yet conducted in the Russian Federation, the Ukraine and the Republic of Belarus. Acquired data suggests the existence of noticeable deteriorating effect of ionizing radiation produced secondary to CNA with the increased incidence of health status disturbances in affected population. Approximately 3500 inhabitants from the Republic of Moldova took part in the Chernobyl nuclear accident consequences liquidation. Study objective comprises the determination of clinical, immunological and cytogenetic features in PDCCNA from the Republic of Moldova and their descendants. Between 1996 and 2005 period 850 patients - participants in removal of consequences of Chernobyl

  3. Carbohydrates Through Animation: Preliminary Step

    Directory of Open Access Journals (Sweden)

    J.K. Sugai

    2004-05-01

    Full Text Available Methods of education are changing, so the educational tools must change too. The developmentof the systems of information and communication gave the opportunity to bring new technology tothe learning process. Modern education needs interactive programs that may be available to theacademic community, in order to ease the learning process and sharing of the knowledge. Then,an educational software on Carbohydrates is being developed using concept maps and FLASH-MXanimations program, and approached through six modules. The introduction of Carbohydrates wasmade by the module Carbohydrates on Nature, which shows the animations gures of a teacher andstudents, visiting a farm, identifying the carbohydrates found in vegetables, animals, and microor-ganisms, integrated by links containing short texts to help understanding the structure and functionof carbohydrates. This module was presented, as pilot experiment, to teachers and students, whichdemonstrated satisfaction, and high receptivity, by using animation and interactivitys program asstrategy to biochemistrys education. The present work is part of the project Biochemistry throughanimation, which is having continuity.

  4. Medical aspects of sports injuries.

    OpenAIRE

    Adams, I D

    1981-01-01

    The aims of medicine in sport--treatment and prevention of injury of high-performance athletes, rehabilitation--and its beneficial effects are considered. The types of sporting injuries are described. Collision and contact sports tend to be characterised by injuries caused by direct or indirect trauma, while athletic injuries tend to result from a variety of factors that, instead of producing excellence as intended, produce injury. The physiological changes in a top-class sportsman may also b...

  5. Medical Aspects of Liver Transplantation

    OpenAIRE

    Van Thiel, David H.; Schade, Robert R.; GAVALER, JUDITH S.; Shaw, Byers W.; Iwatsuki, Shunzaburo; Starzl, Thomas E.

    1984-01-01

    The methods used to screen prospective candidates for orthotopic liver transplantation are described. Both the indication and the contraindications for the procedure are discussed. The timing of the procedure during the course of an individual candidate’s liver disease is also discussed. Additionally, the institutional requirements of a liver transplant center are identified. Finally, the problems experienced by a liver transplant patient and his physician during the postoperative period are ...

  6. Carbohydrates of human immunodeficiency virus

    DEFF Research Database (Denmark)

    Hansen, J E

    1992-01-01

    Elucidation of the mechanism by which viral infection induces the appearance of carbohydrate neoantigens is highly important. Results from such studies could be expected to be significant for a general understanding of the regulation of glycosylation, and perhaps especially important for the unde...

  7. Carbohydrates - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Carbohydrates URL of this page: https://medlineplus.gov/languages/carbohydrates.html Other topics A-Z A B ...

  8. Importance of low carbohydrate diets in diabetes management

    OpenAIRE

    RM Hall; Parry Strong A; Krebs JD

    2016-01-01

    Rosemary M Hall, Amber Parry Strong, Jeremy D KrebsCentre for Endocrine, Diabetes and Obesity Research, Capital and Coast District Health Board, Wellington, New Zealand Abstract: Dietary strategies are fundamental in the management of diabetes. Historically, strict dietary control with a low carbohydrate diet was the only treatment option. With increasingly effective medications, the importance of dietary change decreased. Recommendations focused on reducing dietary fat to prevent atheroscle...

  9. Fluorous-based carbohydrate quartz crystal microbalance.

    Science.gov (United States)

    Chen, Lei; Sun, Pengfei; Chen, Guosong

    2015-03-20

    Fluorous chemistry has brought many applications from catalysis to separation science, from supramolecular materials to analytical chemistry. However, fluorous-based quartz crystal microbalance (QCM) has not been reported so far. In the current paper, fluorous interaction has been firstly utilized in QCM, and carbohydrate-protein interaction and carbohydrate-carbohydrate interaction have been detected afterward. PMID:25541017

  10. Interactions of carbohydrates and proteins by fluorophore-assisted carbohydrate electrophoresis

    Indian Academy of Sciences (India)

    Gang-Liang Huang; Xin-Ya Mei; Peng-George Wang

    2006-06-01

    A sensitive, specific, and rapid method for the detection of carbohydrate-protein interactions is demonstrated by fluorophore-assisted carbohydrate electrophoresis (FACE). The procedure is simple and the cost is low. The advantage of this method is that carbohydrate-protein interactions can be easily displayed by FACE, and the carbohydrates do not need to be purified.

  11. Importance of low carbohydrate diets in diabetes management

    Directory of Open Access Journals (Sweden)

    Hall RM

    2016-03-01

    Full Text Available Rosemary M Hall, Amber Parry Strong, Jeremy D KrebsCentre for Endocrine, Diabetes and Obesity Research, Capital and Coast District Health Board, Wellington, New Zealand Abstract: Dietary strategies are fundamental in the management of diabetes. Historically, strict dietary control with a low carbohydrate diet was the only treatment option. With increasingly effective medications, the importance of dietary change decreased. Recommendations focused on reducing dietary fat to prevent atherosclerotic disease, with decreasing emphasis on the amount and quality of carbohydrate. As the prevalence of obesity and diabetes escalates, attention has returned to the macronutrient composition of the diet. Very low carbohydrate diets (VLCD's have demonstrated effective initial weight loss and improvement in glycemic control, but difficult long-term acceptability and worsening lipid profile. Modifications to the very low carbohydrate (VLC have included limiting saturated fat and increasing carbohydrate (CHO and protein. Reducing saturated fat appears pivotal in reducing low-density lipoprotein (LDL cholesterol and may mitigate adverse effects of traditional VLCD's. Increased dietary protein enhances satiety, reduces energy intake, and improves glycemic homeostasis, but without sustained improvements in glycemic control or cardiovascular risk over and above the effect of weight loss. Additionally, recent studies in type 1 diabetes mellitus suggest promising benefits to diabetes control with low carbohydrate diets, without concerning effects on ketosis or hypoglycemia. Dietary patterns may highlight pertinent associations. For example, Mediterranean-style and paleolithic-type diets, low in fat and carbohydrate, are associated with reduced body weight and improved glycemic and cardiovascular outcomes in type 2 diabetes mellitus (T2DM. A feature of these dietary patterns is low refined CHO and sugar and higher fiber, and it is possible that increasing sugar

  12. Carbohydrate Microarrays in Plant Science

    DEFF Research Database (Denmark)

    Fangel, Jonatan Ulrik; Pedersen, H.L.; Vidal-Melgosa, S.;

    2012-01-01

    Almost all plant cells are surrounded by glycan-rich cell walls, which form much of the plant body and collectively are the largest source of biomass on earth. Plants use polysaccharides for support, defense, signaling, cell adhesion, and as energy storage, and many plant glycans are also important...... industrially and nutritionally. Understanding the biological roles of plant glycans and the effective exploitation of their useful properties requires a detailed understanding of their structures, occurrence, and molecular interactions. Microarray technology has revolutionized the massively high...... plant research and can be used to map glycan populations across large numbers of samples to screen antibodies, carbohydrate binding proteins, and carbohydrate binding modules and to investigate enzyme activities....

  13. Co-occurrence of carbohydrate malabsorption and primary epiploic appendagitis.

    Science.gov (United States)

    Schnedl, Wolfgang J; Kalmar, Peter; Mangge, Harald; Krause, Robert; Wallner-Liebmann, Sandra J

    2015-09-21

    Unspecific abdominal complaints including bloating and irregular bowel movements may be caused by carbohydrate malabsorption syndromes, e.g., lactose and fructose malabsorption. These symptoms were investigated with hydrogen (H2) breath tests and correlated to carbohydrate malabsorption. During performing these H2-breath tests the patient presented with an acute, localized, non-migratory pain in the left lower abdominal quadrant. Primary epiploic appendagitis is a rare cause of abdominal acute or subacute complaints and diagnosis of primary epiploic appendagitis (PEA) is made when computed tomography reveals a characteristic lesion. We report on a patient with co-occurrence of lactose and fructose malabsorption, which was treated successfully with a diet free of culprit carbohydrates, with PEA recovering without medication or surgical treatment within few days. Since the abdominal unspecific symptoms had been present for months, they appeared not to be correlated to the acute localized abdominal pain, therefore we speculate on a random co-occurrence of combined carbohydrate malabsorption and PEA. PMID:26401090

  14. Carbohydrates Through Animation: Preliminary Step

    OpenAIRE

    J.K. Sugai; M.S.R. Figueiredo; R.V. Antônio; P.M Oliveira; V.A Cardoso; Ricardo, J.; Merino, E; Figueiredo, L. F.; D.N. Heidrich

    2004-01-01

    Methods of education are changing, so the educational tools must change too. The developmentof the systems of information and communication gave the opportunity to bring new technology tothe learning process. Modern education needs interactive programs that may be available to theacademic community, in order to ease the learning process and sharing of the knowledge. Then,an educational software on Carbohydrates is being developed using concept maps and FLASH-MXanimations program, and approach...

  15. Biochemical Aspects of Acclimatization of Man to High Altitude Stress

    Directory of Open Access Journals (Sweden)

    K. K. Srivastava

    1975-07-01

    Full Text Available The paper reviews the biochemical aspects of acclimatization of human body to high altitude with particular reference to the adaptive changes in Skeletal muscles, hepatic function, adrenal function and carbohydrate metabolism.

  16. NMR-based, molecular dynamics- and random walk molecular mechanics-supported study of conformational aspects of a carbohydrate ligand (Galβ1-2Galβ1-R) for an animal galectin in the free and in the bound state

    NARCIS (Netherlands)

    Vliegenthart, J.F.G.; Siebert, H.-C; Gilleron, M.; Kaltner, H.; Lieth, C.-W. von der; Kozár, T.; Bovin, N.; Korchagina, E.Y.

    1996-01-01

    The binding of a carbohydrate to a lectin may affect the conformation of the ligand. To address this question for the galectin from chicken liver, the conformation of Gal@b1-R was analyzed in the free and in the galectin-bound state with 2D-ROESY- and 1D- as well as 2D-transferred NOE-experiments. A

  17. Nominal aspect

    DEFF Research Database (Denmark)

    Rijkhoff, Jan

    1991-01-01

    In a general way the notion 'aspect' can be defined as the way in which a property or relation is represented in some dimension. Two kinds of aspect can be distinguished: verbal and nominal aspect. The study of verbal aspect has a long tradition, but nominal aspect has only been introduced recent......' (which will be analysed as nominal aspect markers below), (ii) noun-incorporation, and (iii) predicate nouns....

  18. Carbohydrate Microarrays in Plant Science

    DEFF Research Database (Denmark)

    Fangel, Jonatan Ulrik; Pedersen, H.L.; Vidal-Melgosa, S.; Ahl, Louise Isager; Salmean, A.A.; Egelund, Jack; Rydahl, Maja Gro; Clausen, M.H.; Willats, William George Tycho

    2012-01-01

    Almost all plant cells are surrounded by glycan-rich cell walls, which form much of the plant body and collectively are the largest source of biomass on earth. Plants use polysaccharides for support, defense, signaling, cell adhesion, and as energy storage, and many plant glycans are also importa...... plant research and can be used to map glycan populations across large numbers of samples to screen antibodies, carbohydrate binding proteins, and carbohydrate binding modules and to investigate enzyme activities.......Almost all plant cells are surrounded by glycan-rich cell walls, which form much of the plant body and collectively are the largest source of biomass on earth. Plants use polysaccharides for support, defense, signaling, cell adhesion, and as energy storage, and many plant glycans are also important...... industrially and nutritionally. Understanding the biological roles of plant glycans and the effective exploitation of their useful properties requires a detailed understanding of their structures, occurrence, and molecular interactions. Microarray technology has revolutionized the massively high...

  19. Carbohydrate metabolism in Spirochaeta stenostrepta.

    Science.gov (United States)

    Hespell, R B; Canale-Parola, E

    1970-07-01

    The pathways of carbohydrate metabolism in Spirochaeta stenostrepta, a free-living, strictly anaerobic spirochete, were studied. The organism fermented glucose to ethyl alcohol, acetate, lactate, CO(2), and H(2). Assays of enzymatic activities in cell extracts, and determinations of radioactivity distribution in products formed from (14)C-labeled glucose indicated that S. stenostrepta degraded glucose via the Embden-Meyerhof pathway. The spirochete utilized a clostridial-type clastic reaction to metabolize pyruvate to acetyl-coenzyme A, CO(2), and H(2), without production of formate. Acetyl-coenzyme A was converted to ethyl alcohol by nicotinamide adenine dinucleotide-dependent acetaldehyde and alcohol dehydrogenase activities. Phosphotransacetylase and acetate kinase catalyzed the formation of acetate from acetyl-coenzyme A. Hydrogenase and lactate dehydrogenase activities were detected in cell extracts. A rubredoxin was isolated from cell extracts of S. stenostrepta. Preparations of this rubredoxin stimulated acetyl phosphate formation from pyruvate by diethylaminoethyl cellulose-treated extracts of S. stenostrepta, an indication that rubredoxin may participate in pyruvate cleavage by this spirochete. Nutritional studies showed that S. stenostrepta fermented a variety of carbohydrates, but did not ferment amino acids or other organic acids. An unidentified growth factor present in yeast extract was required by the organism. Exogenous supplements of biotin, riboflavin, and vitamin B(12) were either stimulatory or required for growth. PMID:5423371

  20. Glycosyltransferase engineering for carbohydrate synthesis.

    Science.gov (United States)

    McArthur, John B; Chen, Xi

    2016-02-01

    Glycosyltransferases (GTs) are powerful tools for the synthesis of complex and biologically-important carbohydrates. Wild-type GTs may not have all the properties and functions that are desired for large-scale production of carbohydrates that exist in nature and those with non-natural modifications. With the increasing availability of crystal structures of GTs, especially those in the presence of donor and acceptor analogues, crystal structure-guided rational design has been quite successful in obtaining mutants with desired functionalities. With current limited understanding of the structure-activity relationship of GTs, directed evolution continues to be a useful approach for generating additional mutants with functionality that can be screened for in a high-throughput format. Mutating the amino acid residues constituting or close to the substrate-binding sites of GTs by structure-guided directed evolution (SGDE) further explores the biotechnological potential of GTs that can only be realized through enzyme engineering. This mini-review discusses the progress made towards GT engineering and the lessons learned for future engineering efforts and assay development. PMID:26862198

  1. Application of radiation degraded carbohydrates for plants

    International Nuclear Information System (INIS)

    Radiation degraded carbohydrates such as chitosan, sodium alginate, carageenan, cellulose, pectin, etc. were applied for plant cultivation. Chitosan (poly-β -D-glucosamine) was easily degraded by irradiation and induced various kinds of biological activities such as anti-microbacterial activity, promotion of plant growth, suppression of heavy metal stress on plants, phytoalexins induction, etc. Pectic fragments obtained from degraded pectin also induced the phytoalexins such as glyceollins in soybean and pisafin in pea. The irradiated chitosan shows the higher elicitor activity for pisafin than that of pectin. For the plant growth promotion, alginate derived from brown marine algae, chitosan and ligno-cellulosic extracts show a strong activity. The hot water and ethanol extracts from EFB and sugar cane bagasse were increased by irradiation. These extracts promoted the growth of plants and suppressed the damage on barley with salt and Zn stress. The results show that the degraded polysaccharides by radiation have the potential to induce various biological activities and the products can be use for agricultural and medical fields

  2. Biochemical software: Carbohydrates on Laboratory

    Directory of Open Access Journals (Sweden)

    D.N. Heidrich

    2005-07-01

    Full Text Available Educators around  the  world  are  being  challenged  to  develop  and  design  better and  more  effective strategies for student learning  using a variety  of modern  resources.  In this  present  work, an educa- tional  hypermedia  software  was constructed as a support tool to biochemistry teaching.  Occurrence, structure, main  characteristics and  biological  function  of the  biomolecule  Carbohydrates were pre- sented  through  modules.  The  software was developed  using concept  maps,  ISIS-Draw,  and  FLASH- MX animation program.  The chapter  Carbohydrates on Laboratory illustrates experimental methods of carbohydrates characterization, through  animation of a laboratory scenery.   The  subject was de- veloped showing reactions  as Bial, Benedict, Selliwanoff, Barfoed, Phenol  Sulphuric,  and Iodines, and also enzymatic  reactions  as glucose oxidase and amylase.  There are also links with short texts  in order to help the understanding of the contents  and principles of laboratory practice  as well as background reactions. Application of the software to undergraduate students and high school teachers  showed an excellent  acceptance.   All of them  considered  the  software  a very good learning  tool.  Both  teachers and students welcomed this program  as it is more flexible, and allows the learning in a more individual rhythm. In addition, application of the software would be suitable  to a more effective learning  and it is less expensive than conventional experimental teaching.

  3. Mastering ectomycorrhizal symbiosis: the impact of carbohydrates.

    Science.gov (United States)

    Nehls, Uwe

    2008-01-01

    Mycorrhiza formation is the consequence of a mutualistic interaction between certain soil fungi and plant roots that helps to overcome nutritional limitations faced by the respective partners. In symbiosis, fungi contribute to tree nutrition by means of mineral weathering and mobilization of nutrients from organic matter, and obtain plant-derived carbohydrates as a response. Support with easily degradable carbohydrates seems to be the driving force for fungi to undergo this type of interaction. As a consequence, the fungal hexose uptake capacity is strongly increased in Hartig net hyphae of the model fungi Amanita muscaria and Laccaria bicolor. Next to fast carbohydrate uptake and metabolism, storage carbohydrates are of special interest. In functional A. muscaria ectomycorrhizas, expression and activity of proteins involved in trehalose biosynthesis is mainly localized in hyphae of the Hartig net, indicating an important function of trehalose in generation of a strong carbon sink by fungal hyphae. In symbiosis, fungal partners receive up to approximately 19 times more carbohydrates from their hosts than normal leakage of the root system would cause, resulting in a strong carbohydrate demand of infected roots and, as a consequence, a more efficient plant photosynthesis. To avoid fungal parasitism, the plant seems to have developed mechanisms to control carbohydrate drain towards the fungal partner and link it to the fungus-derived mineral nutrition. In this contribution, current knowledge on fungal strategies to obtain carbohydrates from its host and plant strategies to enable, but also to control and restrict (under certain conditions), carbon transfer are summarized. PMID:18272925

  4. Carbohydrate clearance receptors in transfusion medicine

    DEFF Research Database (Denmark)

    Sørensen, Anne Louise Tølbøll; Clausen, Henrik; Wandall, Hans H

    2012-01-01

    Complex carbohydrates play important functions for circulation of proteins and cells. They provide protective shields and refraction from non-specific interactions with negative charges from sialic acids to enhance circulatory half-life. For recombinant protein therapeutics carbohydrates are espe...

  5. Biochemical software: Carbohydrates on Laboratory

    OpenAIRE

    D.N. Heidrich; M.S.R.B. Figueiredo; R.V. Antonio,; da Costa, J. G.; P.B. Arantes; Figueiredo, L. F.; J.K. Sugai

    2005-01-01

    Educators around  the  world  are  being  challenged  to  develop  and  design  better and  more  effective strategies for student learning  using a variety  of modern  resources.  In this  present  work, an educa- tional  hypermedia  software  was constructed as a support tool to biochemistry teaching.  Occurrence, structure, main  characteristics and  biological  function  of the  biomolecule  Carbohydrates were pre- sented  through  modules.  The  software was developed  using concept  map...

  6. Facultative thermogenesis induced by carbohydrate

    DEFF Research Database (Denmark)

    Astrup, A; Bülow, J; Christensen, N J;

    1986-01-01

    In addition to the obligatory thermogenesis due to processing and storage, carbohydrate ingestion is accompanied by a facultative thermogenesis mediated by catecholamines via beta-adrenoceptors. The anatomical origin of facultative thermogenesis has hitherto not been determined. The possible...... involvement of skeletal muscle was examined in lean, healthy subjects by measuring the response in forearm oxygen consumption to an oral glucose load. The study demonstrates an early component of skeletal muscle thermogenesis coinciding with the local glucose uptake, followed by a late facultative...... thermogenesis. The arterial epinephrine concentration increased to a maximum of 200% above base-line values 4 h after glucose. This value greatly exceeds the physiological threshold for the thermogenic action of epinephrine. In forearm venous blood the corresponding increase in epinephrine was only...

  7. Carbohydrates - Guidelines on Parenteral Nutrition, Chapter 5

    OpenAIRE

    Bolder, U; Ebener, C.; Hauner, H.; Jauch, KW; Kreymann, G.; Ockenga, J.; Traeger, K.; Working group for developing the guidelines for parenteral nutrition of The German Association for Nutritional Medicine

    2009-01-01

    The main role of carbohydrates in the human body is to provide energy. Carbohydrates should always be infused with PN (parenteral nutrition) in combination with amino acids and lipid emulsions to improve nitrogen balance. Glucose should be provided as a standard carbohydrate for PN, whereas the use of xylite is not generally recommended. Fructose solutions should not be used for PN. Approximately 60% of non-protein energy should be supplied as glucose with an intake of 3.0-3.5 g/kg body weigh...

  8. Workshop to establish databases of carbohydrate spectra

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The workshop was organized to formulate guidelines for establishing spectral databases of complex carbohydrates. The databases will enable the scientific community to avoid the great waste of research effort and funds that frequently occurs when carbohydrate chemists are forced to duplicate the structural characterization of previously characterized complex carbohydrates. Chemists waste their effort on repetitive characterizations because in the absence of spectral databases they are unaware they are analyzing a known molecule until they have completely determined its structure. Chemists will be able to avoid much of this wasted effort when the collections of mass and of nuclear magnetic resonance (NMR) spectra initiated at the workshop are subsequently developed into searchable databases. Then scientists only need query the databases with the spectrum or with information defining the spectrum of an unidentified carbohydrate to find out if it has been previously characterized.

  9. Carbohydrate Nutrition and Team Sport Performance.

    Science.gov (United States)

    Williams, Clyde; Rollo, Ian

    2015-11-01

    The common pattern of play in 'team sports' is 'stop and go', i.e. where players perform repeated bouts of brief high-intensity exercise punctuated by lower intensity activity. Sprints are generally 2-4 s long and recovery between sprints is of variable length. Energy production during brief sprints is derived from the degradation of intra-muscular phosphocreatine and glycogen (anaerobic metabolism). Prolonged periods of multiple sprints drain muscle glycogen stores, leading to a decrease in power output and a reduction in general work rate during training and competition. The impact of dietary carbohydrate interventions on team sport performance have been typically assessed using intermittent variable-speed shuttle running over a distance of 20 m. This method has evolved to include specific work to rest ratios and skills specific to team sports such as soccer, rugby and basketball. Increasing liver and muscle carbohydrate stores before sports helps delay the onset of fatigue during prolonged intermittent variable-speed running. Carbohydrate intake during exercise, typically ingested as carbohydrate-electrolyte solutions, is also associated with improved performance. The mechanisms responsible are likely to be the availability of carbohydrate as a substrate for central and peripheral functions. Variable-speed running in hot environments is limited by the degree of hyperthermia before muscle glycogen availability becomes a significant contributor to the onset of fatigue. Finally, ingesting carbohydrate immediately after training and competition will rapidly recover liver and muscle glycogen stores. PMID:26553494

  10. Dietary Carbohydrates and Childhood Functional Abdominal Pain.

    Science.gov (United States)

    Chumpitazi, Bruno P; Shulman, Robert J

    2016-01-01

    Childhood functional gastrointestinal disorders (FGIDs) affect a large number of children throughout the world. Carbohydrates (which provide the majority of calories consumed in the Western diet) have been implicated both as culprits for the etiology of symptoms and as potential therapeutic agents (e.g., fiber) in childhood FGIDs. In this review, we detail how carbohydrate malabsorption may cause gastrointestinal symptoms (e.g., bloating) via the physiologic effects of both increased osmotic activity and increased gas production from bacterial fermentation. Several factors may play a role, including: (1) the amount of carbohydrate ingested; (2) whether ingestion is accompanied by a meal or other food; (3) the rate of gastric emptying (how quickly the meal enters the small intestine); (4) small intestinal transit time (the time it takes for a meal to enter the large intestine after first entering the small intestine); (5) whether the meal contains bacteria with enzymes capable of breaking down the carbohydrate; (6) colonic bacterial adaptation to one's diet, and (7) host factors such as the presence or absence of visceral hypersensitivity. By detailing controlled and uncontrolled trials, we describe how there is a general lack of strong evidence supporting restriction of individual carbohydrates (e.g., lactose, fructose) for childhood FGIDs. We review emerging evidence suggesting that a more comprehensive restriction of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) may be effective. Finally, we review how soluble fiber (a complex carbohydrate) supplementation via randomized controlled intervention trials in childhood functional gastrointestinal disorders has demonstrated efficacy. PMID:27355647

  11. Medical aspects of renewable energy shown by the example of German hospitals; Umweltmedizinische Gesichtspunkte der regenerativen Energieerzeugung am Beispiel deutscher Krankenhaeuser

    Energy Technology Data Exchange (ETDEWEB)

    Waschnewski, R.

    2007-07-01

    To what extend are renewable energy sources used in German hospitals? This is the main objective, this is paper is dealing with. The energy consumption profile is very specific in hospitals. In a questionnaire based study, 79 hospitals have been questioned to elucidate the current situation in German hospitals with respect to energy consumption, and to get an idea of the proportion of alternative energy sources already in use. Our analysis reveals that 14% of the hospitals analysed are already using renewable energy sources. Main sources already utilized are photovoltaic, solar thermal devices, and to a lower extend geothermic energy as well comes into operation. Almost three quarters of the questioned institutions claim, they are aware of funding possibilities and the option of contracting with respect to providing financial support in relation to aquisition of new establishments of alternative energy systems within their institution. Roughly half of the hospital's technical supervisors are aware of the precise energy potential of their institution. The situation about information and awareness with respect to possibilities related to the usage of green energy is deficient and should be improved, but the openness with respect to the topic in general seems to be very positive and advantage of that climate should be taken. Our survey allowed to get an initial estimate on the green energy situation in German hospitals. The focus of the discussion is channeled towards the environmental aspects of the energy production. The survey data allow to conclude that the current information situation is deficient. The data further provide insight into what are the main barriers with respect to the use of renewable energy. Based on our results future analyses can not focus on specific aspects and further evaluate approaches allowing to extend the usage of alternative energy sources in hospitals. (orig.)

  12. Fat and carbohydrates in the diet: Its metabolic contribution to obesity in Chilean women

    International Nuclear Information System (INIS)

    It has been found that children and adults in the Chilean population are getting obese in a rapidly raising proportion. There is a cohort of children less than six years old, which are regularly controlled by the Ministry of Health. From this information and studies carried out at INTA, it is known that the prevalence is raising continuously. Unfortunately, this can not be ascertained in adults where the nutritional situation is assessed only in small groups, which are not representative of the general population. The problem with adults is that the healthy population does not attend to the medical clinics unless they are already ill. The studies conducted in Chilean adults have found that >40% of low socio-economic status (SES) women are suffering from obesity. A intriguing aspect in our situation is that although sedentarism is frequent in adult women (as a possible cause of positive energy balance), their intake is based on a high proportion of carbohydrates (CHO) but not much fat (50-70 g on average). It may be suggested that the excess CHO can be converted into fat through denovo lipogenesis but this process is less important as cause of obesity in humans. A more plausible cause of this problem is likely to be related to the diet. The oxidation hierarchy of macronutrients shows that whenever CHO and fat are available, the former will be firstly oxidised. This way, fat can be spared even when eaten in small amounts, accumulating in the mid-long term. Another important dietary aspect is provided by its fatty acids composition that according to animal studies, seems to modulate fat oxidation. In addition to these, glycemic effects of CHO eaten in combination with the same meal can further potentiate fat storage. This proposal aims to test the dietary effects mentioned above by using indirect calorimetry in tandem with stable isotopes methodologies in a group of normal weight and obese women. (author)

  13. Sanidad Militar y aspectos sanitarios en Fernando Poo durante el gobierno de los brigadieres (1859-1869 The Medical Service and medical aspects in Fernando Poo during the government of the brigadiers (1859-1869

    Directory of Open Access Journals (Sweden)

    J. De Granda Orive

    2011-03-01

    Full Text Available La aprobación en 1858 del primer estatuto orgánico de la colonia estableció una nueva organización administrativa y militar para las islas con la que se buscaba dar un impulso a la colonización de Guinea. Durante los diez años de vigencia de este decreto hubo al frente de la gobernación de estas posesiones cuatro Brigadieres de Ejército y fue una sección del Cuerpo de Sanidad Militar la encargada de la asistencia sanitaria de la población. Se estudia en este trabajo su creación y actividad así como las condiciones ambientales y sanitarias que influyeron en su trabajo.The first organic statutes of the colony passed in 1858, established a new administrative and military organization for the islands which tried to push forward the colonization of Guinea. During the ten years of applicability of this decree the governors of these possessions were four Army brigadiers, while a Medical Service platoon was responsible for the medical care of the population. In this article its creation and activities are studied as well as the environmental and sanitary conditions that had an impact on its work.

  14. Codex dietary fibre definition - Justification for inclusion of carbohydrates from 3 to 9 degrees of polymerisation.

    Science.gov (United States)

    de Menezes, Elizabete Wenzel; Giuntini, Eliana Bistriche; Dan, Milana Cara Tanasov; Sardá, Fabiana Andréa Hoffmann; Lajolo, Franco Maria

    2013-10-01

    The main controversy about the DF definition, adopted by the commission of Codex Alimentarius, refers to the inclusion of carbohydrates of 3-9 degrees of polymerisation (DP), decision which may be made individually by the authorities of each country. Due to the possibility of having two definitions and the negative impact it would cause over the harmonisation of nutritional information, a bibliographic review was carried, from 2009 to 2011, aiming to gather justifications for the inclusion of carbohydrates of 3-9 DP in the definition. The current review presents scientific bases that are directed to three topics: physiological aspects; repercussion over the analytical method; and impact on consumers and other users. The decision of including unavailable carbohydrates of 3-9 DP in the definition of DF may cause effective global harmonisation in the nutritional labelling, considering that the main goal is to help consumers choose healthy foods. PMID:23601410

  15. Investigating the condition of medical counseling and some of clinical aspects for fasting in holy month of Ramadan from the perspective of diabetic and hypertensive patients

    Directory of Open Access Journals (Sweden)

    Ahmad Mahmoudian

    2015-06-01

    Full Text Available Introduction: Although fasting has many benefits for health, it can be dangerous for patients. So it is necessary that physicians have adequate information about clinical aspects of fasting and they should advice patients. Therefore in this study we analyses the condition of physicians counseling about fasting from the perspective of patients. Methods:In this descriptive analytical cross-sectional study, patients with diabetes and hypertension who were going to doctors in Isfahan in holy month of Ramadan of 2012 and 2013 completed the questionnaires. A valid self-regulation questionnaire including patient`s satisfaction from the quality of physicians counseling about fasting (In the area of education, evaluation of the patient condition, communication /relationship with patients, caring for diseases in holy Ramadan and the incidence of symptoms in fasting had been used with  = 0.76. The patients completed the questionnaire after visit. The data was analyzed by Independent t-test, chi-square, Regression, one-way ANOVA in the19 spss software. Results: 285 patients, 199(69.8% female and 86(30.2% male, were selected. The mean satisfaction score of counseling was 70.50 ±13.23. The highest score (75.36±14.16 was referred to counseling of physician, and the least score (66.09±18.84 to patient assessment by physician. Mean score of Patients' satisfaction of specialists was higher than of general practitioner (p-value

  16. Effect of carbohydrate ingestion subsequent to carbohydrate supercompensation on endurance performance.

    Science.gov (United States)

    Kang, J; Robertson, R J; Denys, B G; DaSilva, S G; Visich, P; Suminski, R R; Utter, A C; Goss, F L; Metz, K F

    1995-12-01

    This investigation determined whether carbohydrate ingestion during prolonged moderate-intensity exercise enhanced endurance performance when the exercise was preceded by carbohydrate supercompensation. Seven male trained cyclists performed two trials at an initial power output corresponding to 71 +/- 1% of their peak oxygen consumption. During the trials, subjects ingested either a 6% glucose/sucrose (C) solution or an equal volume of artificially flavored and sweetened placebo (P) every 20 min throughout exercise. Both C and P were preceded by a 6-day carbohydrate supercompensation procedure in which subjects undertook a depletion-taper exercise sequence in conjunction with a moderate- and high-carbohydrate diet regimen. Statistical analysis of time to exhaustion, plasma glucose concentration, carbohydrate oxidation rate, fat oxidation rate, and plasma glycerol concentration indicated that in spite of a carbohydrate supercompensation procedure administered prior to exercise, carbohydrate ingestion during exercise can exert an additional ergogenic effect by preventing a decline in blood glucose levels and maintaining carbohydrate oxidation during the later stages of moderate-intensity exercise. PMID:8605519

  17. Carbohydrate mouth rinse and caffeine improves high-intensity interval running capacity when carbohydrate restricted.

    Science.gov (United States)

    Kasper, Andreas M; Cocking, Scott; Cockayne, Molly; Barnard, Marcus; Tench, Jake; Parker, Liam; McAndrew, John; Langan-Evans, Carl; Close, Graeme L; Morton, James P

    2016-08-01

    We tested the hypothesis that carbohydrate mouth rinsing, alone or in combination with caffeine, augments high-intensity interval (HIT) running capacity undertaken in a carbohydrate-restricted state. Carbohydrate restriction was achieved by performing high-intensity running to volitional exhaustion in the evening prior to the main experimental trials and further refraining from carbohydrate intake in the post-exercise and overnight period. On the subsequent morning, eight males performed 45-min steady-state (SS) exercise (65% [Formula: see text]) followed by HIT running to exhaustion (1-min at 80% [Formula: see text]interspersed with 1-min walking at 6 km/h). Subjects completed 3 trials consisting of placebo capsules (administered immediately prior to SS and immediately before HIT) and placebo mouth rinse at 4-min intervals during HIT (PLACEBO), placebo capsules but 10% carbohydrate mouth rinse (CMR) at corresponding time-points or finally, caffeine capsules (200 mg per dose) plus 10% carbohydrate mouth rinse (CAFF + CMR) at corresponding time-points. Heart rate, capillary glucose, lactate, glycerol and NEFA were not different at exhaustion during HIT (P > 0.05). However, HIT capacity was different (P mouth rinsing and caffeine ingestion improves exercise capacity undertaken in carbohydrate-restricted states. Such nutritional strategies may be advantageous for those athletes who deliberately incorporate elements of training in carbohydrate-restricted states (i.e. the train-low paradigm) into their overall training programme in an attempt to strategically enhance mitochondrial adaptations of skeletal muscle. PMID:26035740

  18. Carbohydrate recognition by the antiviral lectin cyanovirin-N.

    Science.gov (United States)

    Fujimoto, Yukiji K; Green, David F

    2012-12-01

    Cyanovirin-N (CVN) is a cyanobacterial lectin with potent antiviral activity and has been the focus of extensive preclinical investigation as a potential prophylactic for the prevention of the sexual transmission of the human immunodeficiency virus (HIV). Here we present a detailed analysis of carbohydrate recognition by this important protein, using a combination of computational methods, including extensive molecular dynamics simulations and molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) energetic analysis. The simulation results strongly suggest that the observed tendency of wild-type CVN to form domain-swapped dimers is the result of a previously unidentified cis-peptide bond present in the monomeric state. The energetic analysis additionally indicates that the highest-affinity ligand for CVN characterized to date (α-Man-(1,2)-α-Man-(1,2)-α-Man) is recognized asymmetrically by the two binding sites. Finally, we are able to provide a detailed map of the role of all binding site functional groups (both backbone and side chain) to various aspects of molecular recognition: general affinity for cognate ligands, specificity for distinct oligosaccharide targets, and the asymmetric recognition of α-Man-(1,2)-α-Man-(1,2)-α-Man. Taken as a whole, these results complement past experimental characterization (both structural and thermodynamic) to provide the most complete understanding of carbohydrate recognition by CVN to date. The results also provide strong support for the application of similar approaches to the understanding of other protein-carbohydrate complexes. PMID:23057413

  19. Investigation on Carbohydrate Counting Method in Type 1 Diabetic Patients

    Directory of Open Access Journals (Sweden)

    Osman Son

    2014-01-01

    Full Text Available Objective. The results from Diabetes Control and Complications Trial (DCCT have propounded the importance of the approach of treatment by medical nutrition when treating diabetes mellitus (DM. During this study, we tried to inquire carbohydrate (Kh count method’s positive effects on the type 1 DM treatment’s success as well as on the life quality of the patients. Methods. 22 of 37 type 1 DM patients who applied to Eskişehir Osmangazi University, Faculty of Medicine Hospital, Department of Endocrinology and Metabolism, had been treated by Kh count method and 15 of them are treated by multiple dosage intensive insulin treatment with applying standard diabetic diet as a control group and both of groups were under close follow-up for 6 months. Required approval was taken from the Ethical Committee of Eskişehir Osmangazi University, Medical Faculty, as well as informed consent from the patients. The body weight of patients who are treated by carbohydrate count method and multiple dosage intensive insulin treatment during the study beginning and after 6-month term, body mass index, and body compositions are analyzed. A short life quality and medical research survey applied. At statistical analysis, t-test, chi-squared test, and Mann-Whitney U test were used. Results. There had been no significant change determined at glycemic control indicators between the Kh counting group and the standard diabetic diet and multiple dosage insulin treatment group in our study. Conclusion. As a result, Kh counting method which offers a flexible nutrition plan to diabetic individuals is a functional method.

  20. Conducting the Medical History

    Science.gov (United States)

    Finkel, Martin A.; Alexander, Randell A.

    2011-01-01

    A key portion of the medical evaluation of child sexual abuse is the medical history. This differs from interviews or histories obtained by other professionals in that it is focuses more on the health and well-being of the child. Careful questions should be asked about all aspects of the child's medical history by a skilled, compassionate,…

  1. Practical aspects of change management at the Obstetrics and Gynecology Clinic at the University Hospital of Medical Sciences in Poznań, Poland

    Directory of Open Access Journals (Sweden)

    Maciej Sobkowski

    2014-06-01

    Full Text Available introduction and objectives. Recent changes to the Polish healthcare system have forced healthcare managers and administrators to implement modern instruments for strategic and operations management. The main aim of the study was to analyze the effect of managerial decisions in the area of human resources, resulting from the adopted restructuring program, on the economic situation of the OGCH, PUMS. material and methods. The research material comprised of secondary sources on finance, accounting and human resources data: financial statements, analysis of costs incurred by individual hospital departments, reports on the implementation of NHF contracts for providing health services and on hospital workforce at the time of the study, as well as the results of patient satisfaction survey at the OGCH, PUMS. results. After implementation of the restructuring program all clinics apart from one – Surgical Gynecology Clinic – reached better beds occupancy rates in 2012 as compared to 2009, as well as significantly improved profit/per hospital bed. Over the course of three years, since the launch of the hospital restructuring program, a significant (20% increase in the revenues from selling healthcare services and a simultaneous decrease (2% of the operating cost was observed. conclusions. Inclusion of department heads into the decision making processes of managerial accounting seems to be necessary to improve the overall financial condition of a hospital. However, it requires a more flexible hospital structure, what can be achieved by implementing a divisional organizational structure, which grants individual organizational units a certain autonomy in the process of making medical-financial decisions.

  2. Potential effect of ultrasound on carbohydrates.

    Science.gov (United States)

    Bera, Smritilekha; Mondal, Dhananjoy; Martin, Jacob T; Singh, Man

    2015-06-17

    The use of ultrasound has emerged as one of the most useful alternative energy sources for the synthesis of carbohydrate-derived biologically and pharmaceutically potential compounds. Spectacular advances have been made in the field of sonication-assisted organic reactions, which are known for producing superior yields, enhanced reactivity of the reactant, improved stereoselectivity, and shortened reaction times. Orthogonal protection-deprotection reactions and/or modification and manipulation of functional groups in carbohydrates are common synthetic steps in carbohydrate chemistry. These reaction steps can be driven by the ultrasonic energy generated by acoustic cavitation via the formation and subsequent collapse of ultrasound-induced bubbles. The ultrasound-assisted synthesis of differently functionalised monosaccharides is useful in a wide variety of applications of carbohydrate chemistry such as the glycosylation of oligosaccharides, one pot domino reactions, thioglycoside syntheses, azidoglycoside syntheses, 1,3-dipolar cycloaddition reactions, and syntheses of natural products. This review article covers ultrasound-mediated reactions on carbohydrates that have been described in the literature since 2000. PMID:25954862

  3. Carbohydrate Detection and Lectin Isolation from Tegumental Tissue of Fasciola hepatica

    Directory of Open Access Journals (Sweden)

    MB Molaei Rad

    2010-02-01

    Full Text Available "nBackground: Fascioliasis is a chronic hepatic disease and may be resulted from mechani­cal/molecular parasite adhesion to host liver tissue. The aim of this study was to detect surface car­bohydrate and lectin, carbohydrate-binding protein isolation that might be responsible of this molecular binding."nMethods: The present experimental work was conducted in the Department of Medical Parasitol­ogy and Mycology, School of Public Health, Tehran University of Medical Sciences, Te­hran, Iran.  Fasciola hepatica parasites were collected from abattoir (Saman, Tehran, Iran and surface mannose-carbohydrate was detected by fluorescein isothiocyanate (FITC conju­gated lectin (Lentil. Lectin of tegumental tissue from F. hepatica was isolated by affinity chroma­tography and detected by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE."nResults: Mannose carbohydrate was observed on the surface of tegumental tissue from para­site under fluorescence microscope. Carbohydrate-binding protein or lectin with MW of 50 kDa also was isolated from homogenized tegument of helminth."nConclusion: These results are important for understanding of molecular pathogenesis of F. hepat­ica at the chronic phase of fascioliasis

  4. A randomized pilot trial of a moderate carbohydrate diet compared to a very low carbohydrate diet in overweight or obese individuals with type 2 diabetes mellitus or prediabetes.

    Directory of Open Access Journals (Sweden)

    Laura R Saslow

    Full Text Available We compared the effects of two diets on glycated hemoglobin (HbA1c and other health-related outcomes in overweight or obese adults with type 2 diabetes or prediabetes (HbA1c>6%. We randomized participants to either a medium carbohydrate, low fat, calorie-restricted, carbohydrate counting diet (MCCR consistent with guidelines from the American Diabetes Association (n = 18 or a very low carbohydrate, high fat, non calorie-restricted diet whose goal was to induce nutritional ketosis (LCK, n = 16. We excluded participants receiving insulin; 74% were taking oral diabetes medications. Groups met for 13 sessions over 3 months and were taught diet information and psychological skills to promote behavior change and maintenance. At 3 months, mean HbA1c level was unchanged from baseline in the MCCR diet group, while it decreased 0.6% in the LCK group; there was a significant between group difference in HbA1c change favoring the LCK group (-0.6%, 95% CI, -1.1% to -0.03%, p = 0.04. Forty-four percent of the LCK group discontinued one or more diabetes medications, compared to 11% of the MCCR group (p = 0.03; 31% discontinued sulfonylureas in the LCK group, compared to 5% in the MCCR group (p = 0.05. The LCK group lost 5.5 kg vs. 2.6 kg lost in MCCR group (p = 0.09. Our results suggest that a very low carbohydrate diet coupled with skills to promote behavior change may improve glycemic control in type 2 diabetes while allowing decreases in diabetes medications. This clinical trial was registered with ClinicalTrials.gov, number NCT01713764.

  5. Minimally refined biomass fuel. [carbohydrate-water-alcohol mixture

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, R.K.; Hirschfeld, T.B.

    1981-03-26

    A minimally refined fluid composition, suitable as a fuel mixture and derived from biomass material, is comprised of one or more water-soluble carbohydrates such as sucrose, one or more alcohols having less than four carbons, and water. The carbohydrate provides the fuel source; water-solubilizes the carbohydrate; and the alcohol aids in the combustion of the carbohydrate and reduces the viscosity of the carbohydrate/water solution. Because less energy is required to obtain the carbohydrate from the raw biomass than alcohol, an overall energy savings is realized compared to fuels employing alcohol as the primary fuel.

  6. Impact of medical informatics on medical education.

    Science.gov (United States)

    Hou, S M

    1999-11-01

    In recent years, medical informatics has become a well-recognized branch of medicine. It is a multidisciplinary science that combines information technology and various specialties of medicine. The impact of medical informatics on medical education is advancing along with the rapid developments in computer science. Departments of medical informatics or similar divisions have appeared in schools of medicine in Taiwan in the past 5 years. At National Taiwan University College of Medicine, we offer curricula in basic computer concepts, network concepts, operating systems, word processing, database and data processing, computer media resources, multimedia computer statistics, intelligent health information systems, medical diagnostic support systems, and electronic medical record systems. Distance learning has also been favorably accepted on this campus. Recently, we proposed the concept of a virtual medical campus, which will break the physical barriers of time and space. We expect this revolution to influence every aspect of medicine, especially medical education. PMID:10705693

  7. Crystallization of carbohydrate oxidase from Microdochium nivale

    Czech Academy of Sciences Publication Activity Database

    Dušková, Jarmila; Dohnálek, Jan; Skálová, Tereza; Ostergaard, L. H.; Fuglsang, C. C.; Kolenko, Petr; Štěpánková, Andrea; Hašek, Jindřich

    2009-01-01

    Roč. 65, č. 6 (2009), s. 638-640. ISSN 1744-3091 R&D Projects: GA AV ČR IAA500500701; GA ČR GA305/07/1073 Institutional research plan: CEZ:AV0Z40500505 Keywords : carbohydrate oxidase * crystallization * data processing Subject RIV: CD - Macromolecular Chemistry Impact factor: 0.551, year: 2009

  8. The diagenesis of carbohydrates by hydrogen sulfide

    Science.gov (United States)

    Mango, Frank D.

    1983-08-01

    Carbohydrates react with hydrogen sulfide under low temperature (100° to 200°C) yielding a variety of organosulfur compounds including thiophenes, thiols, sulfides and sulfones. A polymer is also produced, whose elemental composition is within the range of natural coals. When reductive dehydration is carried out in the presence of hydrocarbon, organosulfur compounds are formed in the carbon number range of the hydrocarbon used. In these processes, an active hydrogen transfer catalyst is produced which facilitates the passage of hydrogen between normal paraffins and saccharide units, distributing sulfur between these two families primarily in the form of thiophene rings. The simplicity of these systems - H 2S, carbohydrates, H 2O, hydrocarbon - and the facility of the chemistry would suggest that the carbohydrates and hydrogen sulfide may be important agents in the diagenetic processes leading to petroleum and coal. Carbohydrate reduction by hydrogen sulfide may constitute an important route through which certain organosulfur compounds found in petroleum and coal entered these materials in early diagenesis.

  9. The clinical impact of carbohydrate malabsorption.

    Science.gov (United States)

    Born, Peter

    2011-03-01

    Malabsorption of carbohydrates such as fructose, lactose or sorbitol can often be detected among patients suffering from so-called non specific abdominal complaints. Sometimes the differential diagnosis may be difficult. So far successful treatment consists of dietary interventions only. Nevertheless, many questions are remaining still unanswered. PMID:21429446

  10. Separation and quantification of microalgal carbohydrates.

    Science.gov (United States)

    Templeton, David W; Quinn, Matthew; Van Wychen, Stefanie; Hyman, Deborah; Laurens, Lieve M L

    2012-12-28

    Structural carbohydrates can constitute a large fraction of the dry weight of algal biomass and thus accurate identification and quantification is important for summative mass closure. Two limitations to the accurate characterization of microalgal carbohydrates are the lack of a robust analytical procedure to hydrolyze polymeric carbohydrates to their respective monomers and the subsequent identification and quantification of those monosaccharides. We address the second limitation, chromatographic separation of monosaccharides, here by identifying optimum conditions for the resolution of a synthetic mixture of 13 microalgae-specific monosaccharides, comprised of 8 neutral, 2 amino sugars, 2 uronic acids and 1 alditol (myo-inositol as an internal standard). The synthetic 13-carbohydrate mix showed incomplete resolution across 11 traditional high performance liquid chromatography (HPLC) methods, but showed improved resolution and accurate quantification using anion exchange chromatography (HPAEC) as well as alditol acetate derivatization followed by gas chromatography (for the neutral- and amino-sugars only). We demonstrate the application of monosaccharide quantification using optimized chromatography conditions after sulfuric acid analytical hydrolysis for three model algae strains and compare the quantification and complexity of monosaccharides in analytical hydrolysates relative to a typical terrestrial feedstock, sugarcane bagasse. PMID:23177152

  11. Nutrient and carbohydrate partitioning in sorghum stover

    International Nuclear Information System (INIS)

    Sorghum [Sorghum bicolor (L.) Moench] stover has been demonstrated to be a potential biomass energy source. Complete aboveground crop removal, however, can result in soil degradation. Differential dry matter, nutrient, and carbohydrate partitioning by sorghum cultivars may allow management strategies that return certain parts to the field while removing other portions for alternative uses, such as energy production. A field study was conducted to determine N,P,K, nonstructural carbohydrate, cellulose hemicellulose, and lignin distributions in stover of three diverse sorghum cultivars of differing harvest indices. Determinations were based on total vegetative biomass; total blades; total stalks; and upper middle, and lower blades and stalks. Concentrations of N and P were higher in blades than stalks and generally declines from upper to lower stover parts. Large carbohydrate and lignin concentration differences were observed on the basis of cultivar and stover part. Greater nutrient partitioning to the upper third of the intermediate and forage-type sorghum stovers was observed as compared to the conventional grain cultivar. Stover carbohydrates for all cultivars were mainly contained in the lower two-thirds of the stalk fraction. A system was proposed for returning upper stover portion to soil, while removing remaining portions for alternative uses

  12. General Properties, Occurrence, and Preparation of Carbohydrates

    Science.gov (United States)

    Robyt, John F.

    D-Glucose and its derivatives and analogues, N-acetyl-D-glucosamine, N-acetyl-D-muramic acid, D-glucopyranosyl uronic acid, and D-glucitol represent 99.9% of the carbohydrates on the earth. D-Glucose is found in the free state in human blood and in the combined state in disaccharides, sucrose, lactose, and α,α-trehalose, in cyclic dextrins, and in polysaccharides, starch, glycogen, cellulose, dextrans; N-acetyl-D-glucosamine and an analogue N-acetyl-D-muramic acid are found in bacterial cell wall polysaccharide, murein, along with teichoic acids made up of poly-glycerol or -ribitol phosphodiesters. Other carbohydrates, D-mannose, D-mannuronic acid, D-galactose, N-acetyl-D-galactosamine, D-galacturonic acid, D-iduronic acid, L-guluronic acid, L-rhamnose, L-fucose, D-xylose, and N-acetyl-D-neuraminic acid are found in glycoproteins, hemicelluloses, glycosaminoglycans, and polysaccharides of plant exudates, bacterial capsules, alginates, and heparin. D-Ribofuranose-5-phosphate is found in many coenzymes and is the backbone of RNAs (ribonucleic acid), and 2-deoxy-D-ribofuranose-5-phosphate is the backbone of DNA (deoxyribonucleic acid). D-Fructofuranose is found in sucrose, inulin, and levan. The general properties and occurrence of these carbohydrates and general methods of isolation and preparation of carbohydrates are presented.

  13. MEDICAL ETHICS COURSE IMPROVES MEDICAL PROFESSIONALISM: MEDICAL STUDENTS´ OPINIONS

    Directory of Open Access Journals (Sweden)

    Abdolreza Sotoodeh Jahromi

    2014-01-01

    Full Text Available Training physicians who are expert in many medical aspects is the most improtant mission of medical universities. One of these aspects, is professional behavior achievement. One of the important goals in training of ethics, is recognition of conflicts in different parts of ethics and having logical viewpoint for resolving and analyzing these conflicts. This descriptive and analytical study was done to evaluate the efficacy of medical ethics education in medical students´ professional attitudes improvement. One hundred and two medical students were selected randomly in different steps of education and were questioned and their opinions correlation with stage of education and gender were evaluated. There was a significant difference between female viewpoint (in roles of ethic course which is presented in preclinical step in professional attitude improvement (P = 0.009 and also a significant difference was seen in the viewpoint score between student stage with intern stage (P = 0.031. Medical students in educational student stage believe ethic course improve medical professionalism. Since there is no special course to train medical students in professionalism, some interventions are required in this field to improve this aspect of physicians' professional life.

  14. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets

    OpenAIRE

    De Paoli, A; Rubini, A.; Volek, J S; Grimaldi, K A

    2013-01-01

    Very-low-carbohydrate diets or ketogenic diets have been in use since the 1920s as a therapy for epilepsy and can, in some cases, completely remove the need for medication. From the 1960s onwards they have become widely known as one of the most common methods for obesity treatment. Recent work over the last decade or so has provided evidence of the therapeutic potential of ketogenic diets in many pathological conditions, such as diabetes, polycystic ovary syndrome, acne, neurological diseases...

  15. Cardiovascular Risks Factors and their Relationship with Disorders of Carbohydrate and Lipid Metabolism

    OpenAIRE

    Lilian Leguen Gulgar; Maricel Castellanos; María de Jesús Sánchez Bouza; Mikhail Benet Rodríguez

    2014-01-01

    Background: cardiovascular disease has been the leading cause of death in Cuba, where studies on emerging cardiovascular risk factors as predictors of cardiovascular risk are scarce. Objective: to determine the association between cardiovascular risk factors and disorders of carbohydrate and lipid metabolism. Methods: a correlational study was conducted with a sample of 105 men and women selected from a total of 346 workers of the University of Medical Sciences of Cienfuegos from June 2011 th...

  16. Carbohydrate deficient transferrin (CDT) in alcoholic cirrhosis: a kinetic study

    DEFF Research Database (Denmark)

    Henriksen, Jens Henrik Sahl; Grønbaek, M; Møller, Søren;

    1997-01-01

    controls (n = 8), which indicates a slow turnover rate of carbohydrate deficient transferrin. Food ingestion did not affect the circulating level of carbohydrate deficient transferrin, and the analysis of carbohydrate deficient transferrin was almost unaffected by the presence of ethanol in plasma within...... alcohol intake, but the overlap is substantial in patients with cirrhosis. Carbohydrate deficient transferrin has a low turnover rate in both patients with cirrhosis and normals....

  17. Sociological and medical aspects of Chernobyl accident

    International Nuclear Information System (INIS)

    The sociological survey data, the results of the state of health service in some districts of Gomel and Mogilev regions as well as of the completeness of the fulfillment of state resolutions concerning the liquidation of the Chernobyl accident after effects are given

  18. Sports medical aspects of fitness and wellness

    OpenAIRE

    Hoffmann, G.; Siegfried, I

    2010-01-01

    Kongreßbericht: Seminar des Arbeitskreises Sportmedizin der Akademie für ärztliche Fortbildung und Weiterbildung der Landesärztekammer Hessen. Bad Nauheim, 18.03.2006. Ziel des Seminars war, sportmedizinische und präventivmedizinische Aspekte zu Fitness und Wellness zu präsentieren und hierbei insbesondere auf die historische Entwicklung der Sportmedizin einzugehen sowie Techniken und Wirkungen verschiedener Massageformen und ganzheitliche asiatische Gesundheitsansätze und Bewegungskünste zu ...

  19. Evaluation of natural phenolic antioxidants in traditional Chinese medicines as carbohydrate absorption modulators for potential development of anti-hyperglycemic functional foods

    OpenAIRE

    Wong, Wing-chiu; 王咏釗

    2013-01-01

    The purpose of this study was to design and develop anti-hyperglycemic functional foods containing phenolic carbohydrate absorption modulator. Physical, chemical, structural and digestive aspects of the reactions of carbohydrates in the presence of phenolic extracts of traditional Chinese medicines were investigated. Water extracts of 14 traditional Chinese medicinal (TCM) plants with reputation of usefulness in treating diabetes were examined for total phenolic contents, antioxidant acti...

  20. interdisciplinary aspects

    OpenAIRE

    Kempf, Davorin

    2010-01-01

    Summary: Symmetry is a universal principle in nature, sciences and arts. Generally speaking symmetry means that something looks the same when observed from certain different aspects. Symmetry is almost always broken – more or less, directly (in praxis) or spontaneously (in quantum field theory). There are discrete and continuous symmetries. Various forms of discrete symmetries – like bilateral, translative or rotative – associated with the field of arts, can also be recognized in our natu...

  1. A role for carbohydrate recognition in mammalian sperm-egg binding

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Gary F., E-mail: clarkgf@health.missouri.edu

    2014-08-01

    Highlights: • Mammalian sperm-egg binding as a carbohydrate dependent species recognition event. • The role of carbohydrate recognition in human, mouse and pig sperm-egg binding. • Historical perspective and future directions for research focused on gamete binding. - Abstract: Mammalian fertilization usually requires three sequential cell–cell interactions: (i) initial binding of sperm to the specialized extracellular matrix coating the egg known as the zona pellucida (ZP); (ii) binding of sperm to the ZP via the inner acrosomal membrane that is exposed following the induction of acrosomal exocytosis; and (iii) adhesion of acrosome-reacted sperm to the plasma membrane of the egg cell, enabling subsequent fusion of these gametes. The focus of this review is on the initial binding of intact sperm to the mammalian ZP. Evidence collected over the past fifty years has confirmed that this interaction relies primarily on the recognition of carbohydrate sequences presented on the ZP by lectin-like egg binding proteins located on the plasma membrane of sperm. There is also evidence that the same carbohydrate sequences that mediate binding also function as ligands for lectins on lymphocytes that can inactivate immune responses, likely protecting the egg and the developing embryo up to the stage of blastocyst hatching. The literature related to initial sperm-ZP binding in the three major mammalian models (human, mouse and pig) is discussed. Historical perspectives and future directions for research related to this aspect of gamete adhesion are also presented.

  2. Does Preoperative Carbohydrate Intake Reduces Postoperative Stress Response in Patients Undergoing Valve Replacement Surgeries

    Directory of Open Access Journals (Sweden)

    Hoda Shokri

    2015-01-01

    Full Text Available Background Cardiac surgery is a stress that causes insulin resistance leading to increased insulin requirements. The aim of our study was to evaluate whether preoperative oral intake of carbohydrate rich drinks could improve outcomes and reduce stress response post valve replacement cardiac surgeries. Methods Our prospective study included 20 ASA 1-3 patients undergoing valve replacement cardiac surgeries.10 patients were fasted after midnight while the other 10 patients received 600 ml of carbohydrate bevering in the evening before the procedure and 150 ml of the drink 2 hours before operation. The following was monitored in all patients: hemodynamics after induction of anesthesia till 24 hours postoperative, insulin resistance (exogenous insulin requirement to keep blood sugar below or equal to 10 mmol/l was used as marker, postoperative discomfort using visual analogue scales, and length of ICU stay. Results Preoperative intake of carbohydrate rich drinks significantly reduced the length of ICU stay (p=0.019 due to reduced postoperative inotropic support requirements and time of mechanical ventilation. Significant reduction in postoperative discomfort and reduced stress response .No significant difference in postoperative level of insulin sensitivity between the two groups. Conclusion Our study showed that although preoperative carbohydrate intake does not reduce insulin resistance postoperatively, it significantly improved other aspects of clinical outcome, in terms of reduced ICU stay, reduced postoperative stress and patient discomfort.

  3. Carbohydrate plasma expanders for passive tumor targeting

    DEFF Research Database (Denmark)

    Hoffmann, Stefan; Caysa, Henrike; Kuntsche, Judith;

    2013-01-01

    The objective of this study was to investigate the suitability of carbohydrate plasma volume expanders as a novel polymer platform for tumor targeting. Many synthetic polymers have already been synthesized for targeted tumor therapy, but potential advantages of these carbohydrates include...... inexpensive synthesis, constant availability, a good safety profile, biodegradability and the long clinical use as plasma expanders. Three polymers have been tested for cytotoxicity and cytokine activation in cell cultures and conjugated with a near-infrared fluorescent dye: hydroxyethyl starches (HES 200 k......Da and HES 450 kDa) and dextran (DEX 500 kDa). Particle size and molecular weight distribution were determined by asymmetric flow field-flow fractionation (AF4). The biodistribution was investigated non-invasively in nude mice using multispectral optical imaging. The most promising polymer conjugate was...

  4. Fine carbohydrate recognition of Euphorbia milii lectin.

    Science.gov (United States)

    Irazoqui, Fernando J; Vozari-Hampe, Magdolna M; Lardone, Ricardo D; Villarreal, Marcos A; Sendra, Victor G; Montich, Guillermo G; Trindade, Vera M; Clausen, Henrik; Nores, Gustavo A

    2005-10-14

    Glycans are key structures involved in biological processes such as cell attachment, migration, and invasion. Information coded on cell-surface glycans is frequently deciphered by proteins, as lectins, that recognize specific carbohydrate topology. Here, we describe the fine carbohydrate specificity of Euphorbia milii lectin (EML). Competitive assays using various sugars showed that GalNAc was the strongest inhibitor, and that the hydroxyl axial position of C4 and acetamido on C2 of GalNAc are critical points of EML recognition. A hydrophobic locus adjacent to GalNAc is also an important region for EML binding. Direct binding assays of EML revealed a stereochemical requirement for a structure adjacent to terminal GalNAc, showing that GalNAc residue is a necessary but not sufficient condition for EML interaction. The capacity of EML to bind epithelial tumor cells makes it a potentially useful tool for study of some over-expressed GalNAc glycoconjugates. PMID:16122701

  5. Role of carbohydrate metabolism in grass tetany

    Energy Technology Data Exchange (ETDEWEB)

    Miller, J.K.; Madsen, F.C.; Lentz, D.E.; Hansard, S.L.

    1977-01-01

    Clinical hypomagnesemia is confined primarily to beef cattle in the United States but also occurs in dairy cattle in other countries, probably due to different management practices. During periods when grass tetany is likely, early vegetative temperate zone grasses are usually low in total readily available carbohydrates and magnesium but high in potassium and nitrogen. The tetany syndrome may include hypoglycemia and ketosis, suggesting an imbalance in intermediary energy metabolism. Many enzyme systems critical to cellular metabolism, including those which hydrolyze and transfer phosphate groups, are activated by Mg. Thus, by inference, Mg is required for normal glucose utilization, fat, protein, nucleic acid and coenzyme synthesis, muscle contraction, methyl group transfer, and sulfate, acetate, and formate activation. Numerous clinical and experimental studies suggest an intimate relationship between metabolism of Mg and that of carbohydrate, glucagon, and insulin. The objective is to review this literature and suggest ways in which these relationships might contribute to a chain of events leading to grass tetany.

  6. A rapid stereoselective synthesis of fluorinated carbohydrates

    International Nuclear Information System (INIS)

    Acetyl hypofluorite has been added to six unsaturated carbohydrates which contain the vinyl ether moiety. All reactions were rapid (less than 5 min.) at -78 degrees C and gave, with one exception, high yields of isomerically pure products. The hypofluorite was shown to add exclusively in a cis mode and with a strong preference for a particular 'face' of the double bond. As well as the syntheses, NMR data and preferred conformations for the fluorinated products are also discussed

  7. Cell surface carbohydrates as prognostic markers in human carcinomas

    DEFF Research Database (Denmark)

    Dabelsteen, Erik

    1996-01-01

    cell types; within a given tissue, variation in expression may be related to cell maturation. Tumour-associated carbohydrate structures often reflect a certain stage of cellular development; most of these moieties are structures normally found in other adult or embryonic tissues. There is no unique......Tumour development is usually associated with changes in cell surface carbohydrates. These are often divided into changes related to terminal carbohydrate structures, which include incomplete synthesis and modification of normally existing carbohydrates, and changes in the carbohydrate core...... tumour carbohydrate structure, since certain structures which are tumour-related in one organ may be normal constituents of other tissues. Tumour-associated carbohydrate changes have been used in the diagnosis of human cancers. Recently, however, it has been demonstrated that the expression of some...

  8. Analysis and validation of carbohydrate three-dimensional structures

    International Nuclear Information System (INIS)

    The article summarizes the information that is gained from and the errors that are found in carbohydrate structures in the Protein Data Bank. Validation tools that can locate these errors are described. Knowledge of the three-dimensional structures of the carbohydrate molecules is indispensable for a full understanding of the molecular processes in which carbohydrates are involved, such as protein glycosylation or protein–carbohydrate interactions. The Protein Data Bank (PDB) is a valuable resource for three-dimensional structural information on glycoproteins and protein–carbohydrate complexes. Unfortunately, many carbohydrate moieties in the PDB contain inconsistencies or errors. This article gives an overview of the information that can be obtained from individual PDB entries and from statistical analyses of sets of three-dimensional structures, of typical problems that arise during the analysis of carbohydrate three-dimensional structures and of the validation tools that are currently available to scientists to evaluate the quality of these structures

  9. Medical tourism.

    Science.gov (United States)

    Reed, Christie M

    2008-11-01

    Searches of the literature or Internet using the term "medical tourism" produce two sets of articles: travel for the purpose of delivering health care or travel for the purpose of seeking health care. The first usage primarily appears in the medical literature and is beyond the scope of this article, which focuses on travel to seek health care. Still, there are some aspects these two topics have in common: both are affected by ease and speed of international travel and communication associated with globalization, and both raise questions about continuity of care as well as issues related to cultural, language, and legal differences; both also raise questions about ethics. This article describes some of the motivating factors, contributing elements, and challenges in elucidating trends, as well as implications for clinicians who provide pretravel advice and those who care for ill returning travelers. PMID:19061760

  10. Abortion - medical

    Science.gov (United States)

    ... womb (uterus). There are different types of medical abortions: Therapeutic medical abortion is done because the woman has ... Therapeutic medical abortion; Elective medical abortion; Induced abortion; Nonsurgical abortion

  11. Fundamentals of Medical Ultrasonics

    CERN Document Server

    Postema, Michiel

    2011-01-01

    This book sets out the physical and engineering principles of acoustics and ultrasound as used for medical applications. It covers the basics of linear acoustics, wave propagation, non-linear acoustics, acoustic properties of tissue, transducer components, and ultrasonic imaging modes, as well as the most common diagnostic and therapeutic applications. It offers students and professionals in medical physics and engineering a detailed overview of the technical aspects of medical ultrasonic imaging, whilst serving as a reference for clinical and research staff.

  12. Carbohydrates/nucleosides/RNA-DNA-ligand interactions

    Energy Technology Data Exchange (ETDEWEB)

    Kaptein, R.; McConnell, B.; Serianni, A.S.; Silks, L.A. III

    1994-12-01

    Carbohydrate and nucleotide structural determination using modern spectroscopic techniques is dependent on our ability to label oligonucleotides and oligosaccharides with stable isotopes. Uniform Carbon 13 and Nitrogen 15 labeling of oligonucleotides is important to present-day efforts, which are focused on determining the structure of relatively small oligosaccharides and oligonucleotides, which form the elements of larger structures. Because of the relatively recent interest in three-dimensional structure, the development of techniques used to label them has lagged behind parallel techniques used to label peptides and proteins. Therefore, this group`s discussion focused primarily on problems faced today in obtaining oligonucleotides labeled uniformly with carbon 13 and nitrogen 15.

  13. Chapter 22 (Part 3): Carbohydrate Chemistry

    OpenAIRE

    Christiansen, Mike A

    2012-01-01

    In this video I'll continue teaching you about carbohydrate chemistry. I'll teach you how to inter-covert between open- and close-chained forms of monosaccharides, illustrating their pyranose and furanose forms. I also teach you about alpha vs. beta sugars, which are called anomers, and I compare chair conformations with Haworth projections. I'll also teach you how to form glycosides from simple monosaccharides, with the mechanism. I'll introduce you to a few polysaccharides, which include st...

  14. In defence of medical ethics.

    OpenAIRE

    Kottow, M H

    1999-01-01

    A number of recent publications by the philosopher David Seedhouse are discussed. Although medicine is an eminently ethical enterprise, the technical and ethical aspects of health care practices can be distinguished, therefore justifying the existence of medical ethics and its teaching as a specific part of every medical curriculum. The goal of teaching medical ethics is to make health care practitioners aware of the essential ethical aspects of their work. Furthermore, the contention that ra...

  15. General Aspects

    Science.gov (United States)

    Höfle, Gerhard

    Epothilone is a microbial product, and thus its history may be traced back to the discovery of the respective microbe, Sorangium cellulosum, a bacterium belonging to the taxonomic group of myxobacteria, which originally has been described by Roland Thaxter in 1892 (1). Today this group of organisms comprises around 40 species, one of which is Sorangium cellulosum. For a long time, myxobacteria were only known for their gliding motility and sophisticated life cycle, although it had been occasionally speculated that they might produce secondary metabolites like actinomycetes or bacilli (2). In 1975 Hans Reichenbach and his group at the German Centre for Biotechnology (GBF; now called the Helmholtz Centre for Infection Research) set out to isolate strains of myxobacteria from soil samples collected all over the world, and to examine their secondary metabolism. In 1978, while work was already ongoing, I joined them and took over the chemistry part. In the same year the first structure of a myxobacterial metabolite, ambruticin, was published by a group from Warner-Lambert (3) making us very confident of being on the right track. Ambruticin had been isolated from a Sorangium cellulosum strain, and was identified as a unique cyclopropane polyketide structure exhibiting potentially useful antifungal properties. Ambruticin and its derivatives had been developed for medical application for some time, and recently gained new interest (4).

  16. Carbohydrate-active enzymes from pigmented Bacilli: a genomic approach to assess carbohydrate utilization and degradation

    Directory of Open Access Journals (Sweden)

    Henrissat Bernard

    2011-09-01

    Full Text Available Abstract Background Spore-forming Bacilli are Gram-positive bacteria commonly found in a variety of natural habitats, including soil, water and the gastro-intestinal (GI-tract of animals. Isolates of various Bacillus species produce pigments, mostly carotenoids, with a putative protective role against UV irradiation and oxygen-reactive forms. Results We report the annotation of carbohydrate active enzymes (CAZymes of two pigmented Bacilli isolated from the human GI-tract and belonging to the Bacillus indicus and B. firmus species. A high number of glycoside hydrolases (GHs and carbohydrate binding modules (CBMs were found in both isolates. A detailed analysis of CAZyme families, was performed and supported by growth data. Carbohydrates able to support growth as the sole carbon source negatively effected carotenoid formation in rich medium, suggesting that a catabolite repression-like mechanism controls carotenoid biosynthesis in both Bacilli. Experimental results on biofilm formation confirmed genomic data on the potentials of B. indicus HU36 to produce a levan-based biofilm, while mucin-binding and -degradation experiments supported genomic data suggesting the ability of both Bacilli to degrade mammalian glycans. Conclusions CAZy analyses of the genomes of the two pigmented Bacilli, compared to other Bacillus species and validated by experimental data on carbohydrate utilization, biofilm formation and mucin degradation, suggests that the two pigmented Bacilli are adapted to the intestinal environment and are suited to grow in and colonize the human gut.

  17. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Mavropoulos John C

    2008-12-01

    Full Text Available Abstract Objective Dietary carbohydrate is the major determinant of postprandial glucose levels, and several clinical studies have shown that low-carbohydrate diets improve glycemic control. In this study, we tested the hypothesis that a diet lower in carbohydrate would lead to greater improvement in glycemic control over a 24-week period in patients with obesity and type 2 diabetes mellitus. Research design and methods Eighty-four community volunteers with obesity and type 2 diabetes were randomized to either a low-carbohydrate, ketogenic diet (1c. Results Forty-nine (58.3% participants completed the study. Both interventions led to improvements in hemoglobin A1c, fasting glucose, fasting insulin, and weight loss. The LCKD group had greater improvements in hemoglobin A1c (-1.5% vs. -0.5%, p = 0.03, body weight (-11.1 kg vs. -6.9 kg, p = 0.008, and high density lipoprotein cholesterol (+5.6 mg/dL vs. 0 mg/dL, p Conclusion Dietary modification led to improvements in glycemic control and medication reduction/elimination in motivated volunteers with type 2 diabetes. The diet lower in carbohydrate led to greater improvements in glycemic control, and more frequent medication reduction/elimination than the low glycemic index diet. Lifestyle modification using low carbohydrate interventions is effective for improving and reversing type 2 diabetes.

  18. Tools for glycomics: mapping interactions of carbohydrates in biological systems.

    Science.gov (United States)

    Ratner, Daniel M; Adams, Eddie W; Disney, Matthew D; Seeberger, Peter H

    2004-10-01

    The emerging field of glycomics has been challenged by difficulties associated with studying complex carbohydrates and glycoconjugates. Advances in the development of synthetic tools for glycobiology are poised to overcome some of these challenges and accelerate progress towards our understanding of the roles of carbohydrates in biology. Carbohydrate microarrays, fluorescent neoglycoconjugate probes, and aminoglycoside antibiotic microarrays are among the many new tools becoming available to glycobiologists. PMID:15457538

  19. Synthesis and evaluation of novel carbocyclic carbohydrate analogues

    OpenAIRE

    Adamson, Christopher William

    2016-01-01

    Carbohydrate analogues play an indispensible role in the study of glycan processing enzymes. These compounds have attracted attention as probes of enzyme mechanisms, as chemical tools for the elucidation of enzyme function and as potential pharmaceuticals. The development of organocatalytic aldol chemistry has fundamentally altered the way chemists approach the synthesis of carbohydrate analogues. In this thesis I highlight a novel strategy toward the synthesis of carbocyclic carbohydrate ana...

  20. CARBOHYDRATE INGESTION AND EXERCISE: EFFECTS ON METABOLISM AND PERFORMANCE

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@KEY POINTS ■ Carbohydrate is the preferred fuel for most competitive sports;an inadequate supply of carbohydrate in the body often leads to poor performance. ■ Carbohydrate ingestion during exercise increases blood glucose availability and maintains the ability of the body to use carbohydrate as fuel during exercise.When carbohydrate is consumed during exercise,glucose uptake by muscles is increased,and the breakdown of glycogen in the liver into blood glucose is reduced,thus saving liver glycogen until late in exercise.The use of muscle glycogen for energy is generally unaffected by carbohydrate feeding.However,during prolonged running,the breakdown of muscle glycogen may be slowed because the supply of blood glucose is improved when carbohydrate is consumed.These metabolic responses underlie the performance benefit that accompanies carbohydrate ingestion during exercise. ■ There are some minor differences among glucose,sucrose,and maltodextrins in their effects on metabolism,but each of them can enhance performance when ingested in the appropriate quantity during exercise.Fructose alone is not an effective carbohydrate supplement because of its slow absorption and slow conversion by the body to glucose,but when small amounts of fructose are combined with other carbohydrates,fructose can be beneficial. ■ Ingesting carbohydrate at a rate of 30-60 grams per hour can improve exercise erformance.A good way to achieve this carbohydrate intake is to consume 600-to-1200 ml(20-to-40 oz)of a sports drink during each hour of exercise.Consuming carbohydrate in a beverage provides an added benefit of preventing potentially harmful effects of dehydration on performance.

  1. Renewable Hydrogen Carrier — Carbohydrate: Constructing the Carbon-Neutral Carbohydrate Economy

    Directory of Open Access Journals (Sweden)

    Y.-H. Percival Zhang

    2011-01-01

    Full Text Available The hydrogen economy presents an appealing energy future but its implementation must solve numerous problems ranging from low-cost sustainable production, high-density storage, costly infrastructure, to eliminating safety concern. The use of renewable carbohydrate as a high-density hydrogen carrier and energy source for hydrogen production is possible due to emerging cell-free synthetic biology technology—cell-free synthetic pathway biotransformation (SyPaB. Assembly of numerous enzymes and co-enzymes in vitro can create complicated set of biological reactions or pathways that microorganisms or catalysts cannot complete, for example, C6H10O5 (aq + 7 H2O (l à 12 H2 (g + 6 CO2 (g (PLoS One 2007, 2:e456. Thanks to 100% selectivity of enzymes, modest reaction conditions, and high-purity of generated hydrogen, carbohydrate is a promising hydrogen carrier for end users. Gravimetric density of carbohydrate is 14.8 H2 mass% if water can be recycled from proton exchange membrane fuel cells or 8.33% H2 mass% without water recycling. Renewable carbohydrate can be isolated from plant biomass or would be produced from a combination of solar electricity/hydrogen and carbon dioxide fixation mediated by high-efficiency artificial photosynthesis mediated by SyPaB. The construction of this carbon-neutral carbohydrate economy would address numerous sustainability challenges, such as electricity and hydrogen storage, CO2 fixation and long-term storage, water conservation, transportation fuel production, plus feed and food production.

  2. CARBOHYDRATE INTAKE CONSIDERATIONS FOR YOUNG ATHLETES

    Directory of Open Access Journals (Sweden)

    Veronica Montfort-Steiger

    2007-09-01

    Full Text Available Good nutritional practices are important for exercise performance and health during all ages. Athletes and especially growing children engaged in heavy training have higher energy and nutrient requirements compared to their non-active counterparts. Scientific understanding of sports nutrition for the young athlete is lacking behind the growing number of young athletes engaged in sports. Most of the sports nutrition recommendations given to athletic children and adolescents are based on adult findings due to the deficiency in age specific information in young athletes. Therefore, this review reflects on child specific sports nutrition, particularly on carbohydrate intake and metabolism that distinguishes the child athlete from the adult athlete. Children are characterised to be in an insulin resistance stage during certain periods of maturation, have different glycolytic/metabolic responses during exercise, have a tendency for higher fat oxidation during exercise and show different heat dissipation mechanisms compared to adults. These features point out that young athletes may need different nutritional advice on carbohydrate for exercise to those from adult athletes. Sport drinks for example may need to be adapted to children specific needs. However, more research in this area is warranted to clarify sports nutrition needs of the young athlete to provide better and healthy nutritional guidance to young athletes

  3. Crystallization of carbohydrate oxidase from Microdochium nivale

    International Nuclear Information System (INIS)

    Industrially used carbohydrate oxidase was successfully crystallized in several forms, diffraction data suitable for structural analysis were collected. Microdochium nivale carbohydrate oxidase was produced by heterologous recombinant expression in Aspergillus oryzae, purified and crystallized. The enzyme crystallizes with varying crystal morphologies depending on the crystallization conditions. Several different crystal forms were obtained using the hanging-drop vapour-diffusion method, two of which were used for diffraction measurements. Hexagon-shaped crystals (form I) diffracted to 2.66 Å resolution, with unit-cell parameters a = b = 55.7, c = 610.4 Å and apparent space group P6222. Analysis of the data quality showed almost perfect twinning of the crystals. Attempts to solve the structure by molecular replacement did not give satisfactory results. Recently, clusters of rod-shaped crystals (form II) were grown in a solution containing PEG MME 550. These crystals belonged to the monoclinic system C2, with unit-cell parameters a = 132.9, b = 56.6, c = 86.5 Å, β = 95.7°. Data sets were collected to a resolution of 2.4 Å. The structure was solved by the molecular-replacement method. Model refinement is currently in progress

  4. Postexercise recovery period: carbohydrate and protein metabolism.

    Science.gov (United States)

    Viru, A

    1996-02-01

    The essence of the postexercise recovery period is normalization of function and homeostatic equilibrium, and replenishment of energy resources and accomplishment of the reconstructive function. The repletion of energy stores is actualized in a certain sequence and followed by a transitory supercompensation. The main substrate for repletion of the muscle glycogen store is blood glucose derived from hepatic glucose output as well as from consumption of carbohydrates during the postexercise period. The repletion of liver glycogen is realized less rapidly. It depends to a certain extent on hepatic gluconeogenesis but mainly on supply with exogenous carbohydrates. The constructive function is founded on elevated protein turnover and adaptive protein synthesis. Whereas during and shortly after endurance exercise intensive protein breakdown was found in less active fast-twitch glycolytic fibers, during the later course of the recovery period the protein degradation rate increased together with intensification of protein synthesis rate in more active fast-twitch glycolytic oxidative and slow-twitch oxidative fibers. PMID:8680938

  5. Application of Ozone Concentration Detection in the Medical Aspects and Its Development%臭氧浓度检测在医疗方面的应用及发展

    Institute of Scientific and Technical Information of China (English)

    金海龙; 成少彦; 宋俊杰

    2011-01-01

    This article introduces some commonly used methods of ozone concentration detection,including chemical method, UV absorption method, and electrochemical method etc, introduces the latest four ozone concentration sensors, and summarizes the advantages and disadvantages of each method. In addition, the article emphatically introduces the ozone's applications and development in the medical aspects. Prospects for the use of ozone concentration detection, ozone treatment and ozone therapy instrument are also demonstrated in it. The literature collected and reviewed on ozone concentration detection and ozone therapy includes 37 papers in English, and 50 papers in Chinese.but only 30 articles among them are included in this review (19 in Chinese and 11 in English) , according to the principle of eliminating the old information and repetitive contents. The present paper selects only those on ozone, ozone concentration, ozone therapy and ozone therapy instrument.%本文评述了几种常用的臭氧浓度检测方法,包括化学法、紫外线吸收法和电化学法等,介绍了四种最新的臭氧浓度传感器,总结了各种方法的利弊;另外还着重介绍了臭氧在医疗卫生方面的应用及发展,并对臭氧浓度检测、臭氧治疗和臭氧治疗仪的应用前景进行了展望.共收集到关于臭氧浓度检测以及臭氧治疗的英文文献37篇,中文文献50篇.按照排除资料年久和内容重复的原则,选取包括臭氧、臭氧浓度、臭氧治疗和臭氧治疗仪的文献.总共纳入30篇(中文文献19篇、英文文献11篇)符合要求的文献.

  6. Acute Effects of Carbohydrate Supplementation on Intermittent Sports Performance

    Directory of Open Access Journals (Sweden)

    Lindsay B. Baker

    2015-07-01

    Full Text Available Intermittent sports (e.g., team sports are diverse in their rules and regulations but similar in the pattern of play; that is, intermittent high-intensity movements and the execution of sport-specific skills over a prolonged period of time (~1–2 h. Performance during intermittent sports is dependent upon a combination of anaerobic and aerobic energy systems, both of which rely on muscle glycogen and/or blood glucose as an important substrate for energy production. The aims of this paper are to review: (1 potential biological mechanisms by which carbohydrate may impact intermittent sport performance; (2 the acute effects of carbohydrate ingestion on intermittent sport performance, including intermittent high-intensity exercise capacity, sprinting, jumping, skill, change of direction speed, and cognition; and (3 what recommendations can be derived for carbohydrate intake before/during exercise in intermittent sports based on the available evidence. The most researched intermittent sport is soccer but some sport-specific studies have also been conducted in other sports (e.g., rugby, field hockey, basketball, American football, and racquet sports. Carbohydrate ingestion before/during exercise has been shown in most studies to enhance intermittent high-intensity exercise capacity. However, studies have shown mixed results with regards to the acute effects of carbohydrate intake on sprinting, jumping, skill, change of direction speed, and cognition. In most of these studies the amount of carbohydrate consumed was ~30–60 g/h in the form of a 6%–7% carbohydrate solution comprised of sucrose, glucose, and/or maltodextrin. The magnitude of the impact that carbohydrate ingestion has on intermittent sport performance is likely dependent on the carbohydrate status of the individual; that is, carbohydrate ingestion has the greatest impact on performance under circumstances eliciting fatigue and/or hypoglycemia. Accordingly, carbohydrate ingestion before

  7. Cognitive awareness of carbohydrate intake does not alter exercise-induced lymphocyte apoptosis

    OpenAIRE

    James Wilfred Navalta; Brian Keith McFarlin; Scott Lyons; Scott Wesley Arnett; Mark Anthony Schafer

    2011-01-01

    OBJECTIVE: The purpose of this investigation was to determine whether cognitive awareness of carbohydrate beverage consumption affects exercise‐induced lymphocyte apoptosis, independent of actual carbohydrate intake. INTRODUCTION: Carbohydrate supplementation during aerobic exercise generally protects against the immunosuppressive effects of exercise. It is not currently known whether carbohydrate consumption or simply the knowledge of carbohydrate consumption also has that effect. METHODS: E...

  8. Rethinking the medical in the medical humanities.

    Science.gov (United States)

    O'Neill, Desmond; Jenkins, Elinor; Mawhinney, Rebecca; Cosgrave, Ellen; O'Mahony, Sarah; Guest, Clare; Moss, Hilary

    2016-06-01

    To clinicians there are a number of striking features of the ever-evolving field of the medical humanities. The first is a perception of a predominantly unidirectional relationship between medicine and the humanities, generally in terms of what the arts and humanities have to offer medicine. The second is the portrayal of medical practice in terms of problems and negativities for which the medical humanities are seen to pose the solution rather than viewing medicine as an active and positive contributor to an interdisciplinary project. Paradigms that fail to recognise the contributions of medicine and its practitioners (including students) to the medical humanities, this paper argues, will continue to struggle with definition and acceptance. This paper explores the possibilities for advancing the medical humanities through recognition of the contribution of medicine to the humanities and the importance of engaging with the arts, culture and leisure pursuits of doctors and medical students. Our research shows the richness of cultural engagement of medical students, their broad range of cultural interests and their ability to contribute to research and scholarship in the medical humanities. Mutual recognition of strengths, weaknesses and differences of scholarly approach is critical to successful development of the enterprise. Recognising and building on the interests, sympathies and contributions of medicine and its practitioners to the medical humanities is a fundamental component of this task. Future directions might include introductory courses for humanities scholars in aspects of healthcare and medicine. PMID:26944516

  9. [Determination of the total quantity of carbohydrates in dried yeast].

    Science.gov (United States)

    Maksimenko, O A; Ziukova, L A; Fedorovich, R M

    1975-01-01

    Different colourimetric methods for measuring carbohydrates in yeast have been compared. A method using 5% phenol aqueous solution in the presence of concentrated sulphuric acid has been developed to quantitate carbohydrates. The method has been described as applied to an analysis of dry yeast. PMID:1129224

  10. The role of carbohydrate in dietary prescription for weight loss

    DEFF Research Database (Denmark)

    Astrup, Arne

    to be shown whether a low-glycemic index diet provides benefits beyond this. Low-carbohydrate diets may be an option for inducing weight loss in obese patients, but a very low intake of carbohydrate-rich foods is not commensurate with a healthy and palatable diet in the long term. However, there is...

  11. Why use DFT methods in the study of carbohydrates?

    Science.gov (United States)

    The recent advances in density functional theory (DFT) and computer technology allow us to study systems with more than 100 atoms routinely. This makes it feasible to study large carbohydrate molecules via quantum mechanical methods, whereas in the past, studies of carbohydrates were restricted to ...

  12. Reinforcement effect of soy protein and carbohydrates in polymer composites

    Science.gov (United States)

    The modulus of soft polymer material can be increased by filler reinforcement. A review of using soy protein and carbohydrates as alternative renewable reinforcement material is presented here. Dry soy protein and carbohydrates are rigid and can form strong filler networks through hydrogen-bonding...

  13. Using structure to inform carbohydrate binding module function

    NARCIS (Netherlands)

    Abbott, D. Wade; Lammerts van Bueren, Alicia

    2014-01-01

    Generally, non-catalytic carbohydrate binding module (CBM) specificity has been shown to parallel the catalytic activity of the carbohydrate active enzyme (CAZyme) module it is appended to. With the rapid expansion in metagenomic sequence space for the potential discovery of new CBMs in addition to

  14. Structural and Functional Studies of Peptide-Carbohydrate Mimicry

    Science.gov (United States)

    Johnson, Margaret A.; Pinto, B. Mario

    Certain peptides act as molecular mimics of carbohydrates in that they are specifically recognized by carbohydrate-binding proteins. Peptides that bind to anti-carbohydrate antibodies, carbohydrate-processing enzymes, and lectins have been identified. These peptides are potentially useful as vaccines and therapeutics; for example, immunologically functional peptide molecular mimics (mimotopes) can strengthen or modify immune responses induced by carbohydrate antigens. However, peptides that bind specifically to carbohydrate-binding proteins may not necessarily show the corresponding biological activity, and further selection based on biochemical studies is always required. The degree of structural mimicry required to generate the desired biological activity is therefore an interesting question. This review will discuss recent structural studies of peptide-carbohydrate mimicry employing NMR spectroscopy, X-ray crystallography, and molecular modeling, as well as relevant biochemical data. These studies provide insights into the basis of mimicry at the molecular level. Comparisons with other carbohydrate-mimetic compounds, namely proteins and glycopeptides, will be drawn. Finally, implications for the design of new therapeutic compounds will also be presented.

  15. Application of carbohydrate polymers as corrosion inhibitors for metal substrates in different media: A review.

    Science.gov (United States)

    Umoren, Saviour A; Eduok, Ubong M

    2016-04-20

    Naturally occurring polysaccharides are biopolymers existing as products of biochemical processes in living systems. A wide variety of them have been employed for various material applications; as binders, coatings, drug delivery, corrosion inhibitors etc. This review describes the application of some green and benign carbohydrate biopolymers and their derivatives for inhibition of metal corrosion. Their modes and mechanisms of protection have also been described as directly related to their macromolecular weights, chemical composition and their unique molecular and electronic structures. For instance, cellulose and chitosan possess free amine and hydroxyl groups capable of metal ion chelation and their lone pairs of electrons are readily utilized for coordinate bonding at the metal/solution interface. Some of the carbohydrate polymers reviewed in this work are either pure or modified forms; their grafted systems and nanoparticle composites with multitude potentials for metal protection applications have also been highlighted. Few inhibitors grafted to introduce more compact structures with polar groups capable of increasing the total energy of the surface have also been mentioned. Exudate gums, carboxymethyl and hydroxyethyl cellulose, starch, pectin and pectates, substituted/modified chitosans, carrageenan, dextrin/cyclodextrins and alginates have been elaborately reviewed, including the effects of halide additives on their anticorrosion performances. Aspects of computational/theoretical approach to corrosion monitoring have been recommended for future studies. This non-experimental approach to corrosion could foster a better understanding of the corrosion inhibition processes by correlating actual inhibition mechanisms with molecular structures of these carbohydrate polymers. PMID:26876859

  16. Carbohydrate loading in the preoperative setting.

    Science.gov (United States)

    Hill, L T; Miller, M G A

    2015-03-01

    Nutrition support is an evolving field, and modern clinical nutrition practice should actively incorporate strategies to enhance various clinical outcomes. In surgical patients, clinical benefits can be maximised by nutritional support protocols that minimise and manage the perioperative fasting period. This approach, which includes the perioperative provision of clear carbohydrate-containing fluids, has been shown to be safe, is evidence based, and is supported by many professional societies. Such a strategy has been shown to aid the anaesthetic process and maintain an optimal metabolic state, including improved insulin sensitivity and blunted muscle catabolic activity. Some important consequences of this improved metabolic control include shorter hospital stay and fewer postoperative complications. A proactive multidisciplinary team approach is essential to use this nutrition support strategy with success across a hospital's surgical service. PMID:26294840

  17. Arabinogalactan proteins: focus on carbohydrate active enzymes

    Directory of Open Access Journals (Sweden)

    Eva eKnoch

    2014-06-01

    Full Text Available Arabinogalactan proteins (AGPs are a highly diverse class of cell surface proteoglycans that are commonly found in most plant species. AGPs play important roles in many cellular processes during plant development, such as reproduction, cell proliferation, pattern formation and growth, and in plant-microbe interaction. However, little is known about the molecular mechanisms of their function. Numerous studies using monoclonal antibodies that recognize different AGP glycan epitopes have shown the appearance of a slightly altered AGP glycan in a specific stage of development in plant cells. Therefore, it is anticipated that the biosynthesis and degradation of AGP glycan is tightly regulated during development. Until recently, however, little was known about the enzymes involved in the metabolism of AGP glycans. In this review, we summarize recent discoveries of carbohydrate active enzymes (CAZy; http://www.cazy.org/ involved in the biosynthesis and degradation of AGP glycans, and we discuss the biological role of these enzymes in plant development.

  18. Structure of a streptococcal adhesion carbohydrate receptor

    International Nuclear Information System (INIS)

    Interactions between complementary protein and carbohydrate structures on different genera of human oral bacteria have been implicated in the formation of dental plaque. The carbohydrate receptor on Streptococcus sanguis H1 that is specific for the adhesion on Capnocytophaga ochracea ATCC 33596 has been isolated from the streptococcal cell wall, purified, and structurally characterized. The hexasaccharide repeating unit of the polysaccharide was purified by reverse-phase, amino-bonded silica, and gel permeation high performance liquid chromatography. Earlier studies established that the repeating unit was a hexasaccharide composed of rhamnose, galactose, and glucose in the ration of 2:3:1, respectively. In the present study, determination of absolute configuration by gas chromatography of the trimethylsilyl (+)-2-butyl glycosides revealed that the rhamnose residues were of the L configuration while the hexoses were all D. 252Californium plasma desorption mass spectrometry of the native, the acetylated and the reduced and acetylated hexasaccharide determined that the molecular mass of the native hexasaccharide was 959, and that the 2 rhamnose residues were linked to each other at the nonreducing terminus of the linear molecule. Methylation analysis revealed the positions of the glycosidic linkages in the hexasaccharide and showed that a galactose residue was present at the reducing end. The structural characterization of the hexasaccharide was completed by one and two dimensional 1H and 13C NMR spectroscopy. Complete 1H and 13C assignments for each glycosyl residue were established by two-dimensional (1H,1H) correlation spectroscopy, homonuclear Hartmann-Hahn, and (13C,1H) correlation experiments. The configurations of the glycosidic linkages were inferred from the chemical shifts and coupling constants of the anomeric 1H and 13C resonances

  19. Sensitive LC MS quantitative analysis of carbohydrates by Cs+ attachment.

    Science.gov (United States)

    Rogatsky, Eduard; Jayatillake, Harsha; Goswami, Gayotri; Tomuta, Vlad; Stein, Daniel

    2005-11-01

    The development of a sensitive assay for the quantitative analysis of carbohydrates from human plasma using LC/MS/MS is described in this paper. After sample preparation, carbohydrates were cationized by Cs(+) after their separation by normal phase liquid chromatography on an amino based column. Cesium is capable of forming a quasi-molecular ion [M + Cs](+) with neutral carbohydrate molecules in the positive ion mode of electrospray ionization mass spectrometry. The mass spectrometer was operated in multiple reaction monitoring mode, and transitions [M + 133] --> 133 were monitored (M, carbohydrate molecular weight). The new method is robust, highly sensitive, rapid, and does not require postcolumn addition or derivatization. It is useful in clinical research for measurement of carbohydrate molecules by isotope dilution assay. PMID:16182559

  20. Mining anaerobic digester consortia metagenomes for secreted carbohydrate active enzymes

    DEFF Research Database (Denmark)

    Wilkens, Casper; Busk, Peter Kamp; Pilgaard, Bo;

    . To gain insight into both the degradation of the carbohydrates and the various roles of the microbes in the ADs we have mined metagenomes from both types of ADs for glycoside hydrolases, carbohydrate esterases, polysaccharide lyases, auxiliary activities, and carbohydrate binding modules. The mining...... thermophilic and mesophilic ADs a wide variety of carbohydrate active enzyme functions were discovered in the metagenomic sequencing of the microbial consortia. The most dominating type of glycoside hydrolases were β-glucosidases (up to 27%), α-amylases (up to 10%), α-glucosidases (up to 8%), α......-galactosidases (up to 9%) and β-galactosidases (up to 7%). For carbohydrate esterases the by far most dominating type was acetylxylan esterases (up to 59%) followed by feruloyl esterases (up to 16%). Less than 15 polysaccharide lyases were identified in the different metagenomes and not surprisingly...

  1. Renewable Hydrogen Carrier — Carbohydrate: Constructing the Carbon-Neutral Carbohydrate Economy

    OpenAIRE

    Y.-H. Percival Zhang; Mielenz, Jonathan R.

    2011-01-01

    The hydrogen economy presents an appealing energy future but its implementation must solve numerous problems ranging from low-cost sustainable production, high-density storage, costly infrastructure, to eliminating safety concern. The use of renewable carbohydrate as a high-density hydrogen carrier and energy source for hydrogen production is possible due to emerging cell-free synthetic biology technology—cell-free synthetic pathway biotransformation (SyPaB). Assembly of numerous enzymes and ...

  2. Renewable Hydrogen Carrier — Carbohydrate: Constructing the Carbon-Neutral Carbohydrate Economy

    OpenAIRE

    Y.-H. Percival Zhang; Mielenz, Jonathan R.

    2011-01-01

    The hydrogen economy presents an appealing energy future but its implementation must solve numerous problems ranging from low-cost sustainable production, high-density storage, costly infrastructure, to eliminating safety concern. The use of renewable carbohydrate as a high-density hydrogen carrier and energy source for hydrogen production is possible due to emerging cell-free synthetic biology technology–cell-free synthetic pathway biotransformation (SyPaB). Assembly of numerous enzymes and ...

  3. Medical marijuana

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000899.htm Medical marijuana To use the sharing features on this ... have legalized marijuana for medical use. How Does Medical Marijuana Work? Medical marijuana may be: Smoked Vaporized ...

  4. The case for low carbohydrate diets in diabetes management

    Directory of Open Access Journals (Sweden)

    McFarlane Samy I

    2005-07-01

    Full Text Available Abstract A low fat, high carbohydrate diet in combination with regular exercise is the traditional recommendation for treating diabetes. Compliance with these lifestyle modifications is less than satisfactory, however, and a high carbohydrate diet raises postprandial plasma glucose and insulin secretion, thereby increasing risk of CVD, hypertension, dyslipidemia, obesity and diabetes. Moreover, the current epidemic of diabetes and obesity has been, over the past three decades, accompanied by a significant decrease in fat consumption and an increase in carbohydrate consumption. This apparent failure of the traditional diet, from a public health point of view, indicates that alternative dietary approaches are needed. Because carbohydrate is the major secretagogue of insulin, some form of carbohydrate restriction is a prima facie candidate for dietary control of diabetes. Evidence from various randomized controlled trials in recent years has convinced us that such diets are safe and effective, at least in short-term. These data show low carbohydrate diets to be comparable or better than traditional low fat high carbohydrate diets for weight reduction, improvement in the dyslipidemia of diabetes and metabolic syndrome as well as control of blood pressure, postprandial glycemia and insulin secretion. Furthermore, the ability of low carbohydrate diets to reduce triglycerides and to increase HDL is of particular importance. Resistance to such strategies has been due, in part, to equating it with the popular Atkins diet. However, there are many variations and room for individual physician planning. Some form of low carbohydrate diet, in combination with exercise, is a viable option for patients with diabetes. However, the extreme reduction of carbohydrate of popular diets (

  5. Comparative analysis of carbohydrate active enzymes in Clostridium termitidis CT1112 reveals complex carbohydrate degradation ability.

    Directory of Open Access Journals (Sweden)

    Riffat I Munir

    Full Text Available Clostridium termitidis strain CT1112 is an anaerobic, gram positive, mesophilic, cellulolytic bacillus isolated from the gut of the wood-feeding termite, Nasutitermes lujae. It produces biofuels such as hydrogen and ethanol from cellulose, cellobiose, xylan, xylose, glucose, and other sugars, and therefore could be used for biofuel production from biomass through consolidated bioprocessing. The first step in the production of biofuel from biomass by microorganisms is the hydrolysis of complex carbohydrates present in biomass. This is achieved through the presence of a repertoire of secreted or complexed carbohydrate active enzymes (CAZymes, sometimes organized in an extracellular organelle called cellulosome. To assess the ability and understand the mechanism of polysaccharide hydrolysis in C. termitidis, the recently sequenced strain CT1112 of C. termitidis was analyzed for both CAZymes and cellulosomal components, and compared to other cellulolytic bacteria. A total of 355 CAZyme sequences were identified in C. termitidis, significantly higher than other Clostridial species. Of these, high numbers of glycoside hydrolases (199 and carbohydrate binding modules (95 were identified. The presence of a variety of CAZymes involved with polysaccharide utilization/degradation ability suggests hydrolysis potential for a wide range of polysaccharides. In addition, dockerin-bearing enzymes, cohesion domains and a cellulosomal gene cluster were identified, indicating the presence of potential cellulosome assembly.

  6. Dietary non-digestible carbohydrates and the resistance to intestinal infections

    NARCIS (Netherlands)

    Bruggencate, ten S.J.M.

    2004-01-01

    Keywords: Non-digestible carbohydrates, prebiotics, inulin, FOS, calcium, microflora, short-chain fatty acids, mucin, intestinal permeability, salmonella, infection, rat, humanDietary non-digestible carbohydrates and the resistance to intestinal infectionsNon-digestible carbohydrates (NDC) stimulate

  7. Carbohydrate Content in the GDM Diet: Two Views: View 1: Nutrition Therapy in Gestational Diabetes: The Case for Complex Carbohydrates.

    Science.gov (United States)

    Hernandez, Teri L

    2016-05-01

    IN BRIEF Restriction of dietary carbohydrate has been the cornerstone for treatment of gestational diabetes mellitus (GDM). However, there is evidence that a balanced liberalization of complex carbohydrate as part of an overall eating plan in GDM meets treatment goals and may mitigate maternal adipose tissue insulin resistance, both of which may promote optimal metabolic outcomes for mother and offspring. PMID:27182176

  8. Catalytic Deoxydehydration of Carbohydrates and Polyols to Chemicals and Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Nicholas, Kenneth M. [Univ. of Oklahoma, Norman, OK (United States)

    2016-01-15

    As the world's fossil fuel resources are being depleted and their costs increase, there is an urgent need to discover and develop new processes for the conversion of renewable, biomass resources into fuels and chemical feedstocks. Research and development in this area have been given high priority by both governmental agencies and industry. To increase the energy content and decrease the boiling points of biomass-derived carbohydrates and polyols to the useful liquid range it is necessary to chemically remove water (dehydrate) and, preferably, oxygen (deoxygenate/reduce). The poly-hydroxylic nature of carbohydrates is attractive for their use as functionalized chemical building blocks, but it presents a daunting challenge for their selective conversion to single product chemicals or fuels. The long term, practical objective of this project is to develop catalytic processes for the deoxydehydration (DODH) of biomass-derived carbohydrates and polyols to produce unsaturated alcohols and hydrocarbons of value as chemical feedstocks and fuels; DODH: polyol + reductant --(LMOx catalyst)--> unsaturate + oxidized reductant + H2O. Limited prior studies have established the viability of the DODH process with expensive phosphine reductants and rhenium-catalysts. Initial studies in the PI's laboratory have now demonstrated: 1) the moderately efficient conversion of glycols to olefins by the economical sulfite salts is catalyzed by MeReO3 and Z+ReO4-; 2) effective phosphine-based catalytic DODH of representative glycols to olefins by cheap LMoO2 complexes; and 3) computational studies (with K. Houk, UCLA) have identified several Mo-, W-, and V-oxo complexes that are likely to catalyze glycol DODH. Seeking practically useful DODH reactions of complex polyols and new understanding of the reactivity of polyoxo-metal species with biomass-oxygenates we will employ a two-pronged approach: 1) investigate experimentally the reactivity, both stoichiometric and catalytic, of

  9. Regulatory aspects on nanomedicines.

    Science.gov (United States)

    Sainz, Vanessa; Conniot, João; Matos, Ana I; Peres, Carina; Zupancic, Eva; Moura, Liane; Silva, Liana C; Florindo, Helena F; Gaspar, Rogério S

    2015-12-18

    Nanomedicines have been in the forefront of pharmaceutical research in the last decades, creating new challenges for research community, industry, and regulators. There is a strong demand for the fast development of scientific and technological tools to address unmet medical needs, thus improving human health care and life quality. Tremendous advances in the biomaterials and nanotechnology fields have prompted their use as promising tools to overcome important drawbacks, mostly associated to the non-specific effects of conventional therapeutic approaches. However, the wide range of application of nanomedicines demands a profound knowledge and characterization of these complex products. Their properties need to be extensively understood to avoid unpredicted effects on patients, such as potential immune reactivity. Research policy and alliances have been bringing together scientists, regulators, industry, and, more frequently in recent years, patient representatives and patient advocacy institutions. In order to successfully enhance the development of new technologies, improved strategies for research-based corporate organizations, more integrated research tools dealing with appropriate translational requirements aiming at clinical development, and proactive regulatory policies are essential in the near future. This review focuses on the most important aspects currently recognized as key factors for the regulation of nanomedicines, discussing the efforts under development by industry and regulatory agencies to promote their translation into the market. Regulatory Science aspects driving a faster and safer development of nanomedicines will be a central issue for the next years. PMID:26260323

  10. Targeting the Cryptococcus neoformans var. grubii Cell Wall Using Lectins: Study of the Carbohydrate-Binding Domain

    OpenAIRE

    Pamella de Brito Ximenes; Eduardo Isidoro Carneiro Beltrão; Danielle Patrícia Cerqueira Macêdo; Maria Daniela Silva Buonafina; Reginaldo Gonçalves de Lima-Neto; Rejane Pereira Neves

    2015-01-01

    Cryptococcus neoformans var. grubii is considered to be the major cause of cryptococcosis in immunosuppressed patients. Understanding cell wall glycoproteins using lectins is of medical interest and can contribute to specific therapy. The aim of this study was to evaluate the carbohydrates on the cell wall of Cryptococcus neoformans var. grubii clinical isolates, using a fluorescein isothiocyanate-lectin binding protocol. Thirty yeast strains stocked in the culture collection were cultivated ...

  11. Medical Art Therapy

    OpenAIRE

    Aydın, Birgül

    2012-01-01

    Art therapy is a form of expressive therapy that uses art materials. Art therapy combines traditional psychotherapeutic theories and techniques with an understanding of the psychological aspects of the creative process, especially the affective properties of the different art materials. Medical art therapy has been defined as the clinical application of art expression and imagery with individuals who are physically ill, experiencing physical trauma or undergoing invasive or aggressive medical...

  12. Psychiatric Aspects of Infertility

    Directory of Open Access Journals (Sweden)

    Hacer Sezgin

    2014-06-01

    Full Text Available Infertility can be defined as a crisis with cultural, religious, and class related aspects, which coexists with medical, psychiatric, psychological, and social problems. Relation between psychiatric and psychological factors stem from a mutual interaction of both. Family is an important institution in maintaining human existence and raising individuals in line with society's expectations. Fertility and reproduction are seen as universal functions unique to women with raising children as the expected result of the family institution. Incidence of infertility has increased recently and can become a life crisis for a couple. Even though not being able to have a child affects both sexes emotionally, women feel greater amounts of stress, pressure, anxiety, and depression.Consequences of infertility arise from short and long-term devastating effects on both individual's physical and mental health, and marital system. Many studies focus on infertility related psychological and psychiatric disorders (depression, anxiety, grief, marital conflict, gender differences, relation between the causes of infertility and psychopathology, the effects of psychiatric evaluation and intervention -when necessaryon the course of infertility treatment, pregnancy rates, and childbirth. The most important underlying causes of high levels of stress and anxiety that infertile women experience are the loss of maternity, reproduction, sense of self, and genetic continuity. In this review article is to investigate the relationship between medically unexplained symptoms and psychiatric symptoms. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(2.000: 165-185

  13. Medical Information Resources Development in China

    Institute of Scientific and Technical Information of China (English)

    Hao Jiying; Zhan Youxiang

    2005-01-01

    This paper expatiates on the recent medical information resource development and utilization in China. A comparison isdrawn between the medical information resource development and utilization in China and developed countries in five aspects: outlay of medical information resources, constructing and sharing of medical information resources, medical information policy and related rules of law, revelation of library collections and quadratic exploiture, etc. Finally some suggestions are put forward for the medical information resource development in China.

  14. Symphonic electronic music: social aspects

    OpenAIRE

    Enfi A.

    2011-01-01

    In the article «Sympho-electronic music as deep-essential psychotherapy's tool of art-humanitarian practice» we provide definitions and characteristics of the new musicological concepts: «sympho-electronic music» (SEM), and show many benefits of using this music in depth-essential psychotherapy of art-humanitarian creativity, based on the implementation of major principles and basic medical-psychological aspects of the Essence Coding Theory (ECT). Demonstrated...

  15. Linking Bacillus cereus Genotypes and Carbohydrate Utilization Capacity

    Science.gov (United States)

    Warda, Alicja K.; Siezen, Roland J.; Boekhorst, Jos; Wells-Bennik, Marjon H. J.; de Jong, Anne; Kuipers, Oscar P.; Nierop Groot, Masja N.; Abee, Tjakko

    2016-01-01

    We characterised carbohydrate utilisation of 20 newly sequenced Bacillus cereus strains isolated from food products and food processing environments and two laboratory strains, B. cereus ATCC 10987 and B. cereus ATCC 14579. Subsequently, genome sequences of these strains were analysed together with 11 additional B. cereus reference genomes to provide an overview of the different types of carbohydrate transporters and utilization systems found in B. cereus strains. The combined application of API tests, defined growth media experiments and comparative genomics enabled us to link the carbohydrate utilisation capacity of 22 B. cereus strains with their genome content and in some cases to the panC phylogenetic grouping. A core set of carbohydrates including glucose, fructose, maltose, trehalose, N-acetyl-glucosamine, and ribose could be used by all strains, whereas utilisation of other carbohydrates like xylose, galactose, and lactose, and typical host-derived carbohydrates such as fucose, mannose, N-acetyl-galactosamine and inositol is limited to a subset of strains. Finally, the roles of selected carbohydrate transporters and utilisation systems in specific niches such as soil, foods and the human host are discussed. PMID:27272929

  16. Contribution of plant carbohydrates to sedimentary carbon mineralization

    Energy Technology Data Exchange (ETDEWEB)

    Vichkovitten, T.; Holmer, M. [University of Southern Denmark, Odense (Denmark). Institute of Biology

    2004-09-01

    The decomposition of different types of organic matter in marine sediments, including eelgrass (Zostera marina) leaves, roots and rhizomes and a macroalga (Polysiphonia spp.), was studied under anoxic conditions using decomposition bags over a period of 24 weeks. The carbohydrate composition of the plant materials and sediment was analyzed using high performance liquid chromatography (HPLC) with pulsed amperometric detection (PAD) and the total sum of individual sugars was taken to represent the total carbohydrate content. The alga was degraded more rapidly than other plant materials, while eelgrass rhizome was recalcitrant to decomposition. The non-structural carbohydrate pool from all plant materials degraded quickly and was gone within the 24-week experiment. A clear reduction in carbohydrate yield for the plant materials provided the most consistent indicator of decomposition status. There was no evident change in carbohydrate amount and composition in the sediment during the decomposition experiments and the non-structural carbohydrates from plant materials were thus more labile and readily available for bacterial decomposition than the bulk of carbohydrates in the sediments. (author)

  17. Linking Bacillus cereus Genotypes and Carbohydrate Utilization Capacity.

    Directory of Open Access Journals (Sweden)

    Alicja K Warda

    Full Text Available We characterised carbohydrate utilisation of 20 newly sequenced Bacillus cereus strains isolated from food products and food processing environments and two laboratory strains, B. cereus ATCC 10987 and B. cereus ATCC 14579. Subsequently, genome sequences of these strains were analysed together with 11 additional B. cereus reference genomes to provide an overview of the different types of carbohydrate transporters and utilization systems found in B. cereus strains. The combined application of API tests, defined growth media experiments and comparative genomics enabled us to link the carbohydrate utilisation capacity of 22 B. cereus strains with their genome content and in some cases to the panC phylogenetic grouping. A core set of carbohydrates including glucose, fructose, maltose, trehalose, N-acetyl-glucosamine, and ribose could be used by all strains, whereas utilisation of other carbohydrates like xylose, galactose, and lactose, and typical host-derived carbohydrates such as fucose, mannose, N-acetyl-galactosamine and inositol is limited to a subset of strains. Finally, the roles of selected carbohydrate transporters and utilisation systems in specific niches such as soil, foods and the human host are discussed.

  18. Linking Bacillus cereus Genotypes and Carbohydrate Utilization Capacity.

    Science.gov (United States)

    Warda, Alicja K; Siezen, Roland J; Boekhorst, Jos; Wells-Bennik, Marjon H J; de Jong, Anne; Kuipers, Oscar P; Nierop Groot, Masja N; Abee, Tjakko

    2016-01-01

    We characterised carbohydrate utilisation of 20 newly sequenced Bacillus cereus strains isolated from food products and food processing environments and two laboratory strains, B. cereus ATCC 10987 and B. cereus ATCC 14579. Subsequently, genome sequences of these strains were analysed together with 11 additional B. cereus reference genomes to provide an overview of the different types of carbohydrate transporters and utilization systems found in B. cereus strains. The combined application of API tests, defined growth media experiments and comparative genomics enabled us to link the carbohydrate utilisation capacity of 22 B. cereus strains with their genome content and in some cases to the panC phylogenetic grouping. A core set of carbohydrates including glucose, fructose, maltose, trehalose, N-acetyl-glucosamine, and ribose could be used by all strains, whereas utilisation of other carbohydrates like xylose, galactose, and lactose, and typical host-derived carbohydrates such as fucose, mannose, N-acetyl-galactosamine and inositol is limited to a subset of strains. Finally, the roles of selected carbohydrate transporters and utilisation systems in specific niches such as soil, foods and the human host are discussed. PMID:27272929

  19. Aspects and Polymorphism in AspectJ

    DEFF Research Database (Denmark)

    Lorenz, David Harel; Ernst, Erik

    -oriented programming (AOP). In AOP, pieces of crosscutting behavior are extracted from the base code and localized in aspects, losing as a result their polymorphic capabilities while introducing new and unexplored issues. In this paper, we explore what kinds of polymorphism AOP languages should support, using Aspect......J as the basis for the presentation. The results are not exclusive to AspectJ---aspectual polymorphism may make aspects in any comparable AOSD language more expressive and reusable across programs, while preserving safety....

  20. Investigations into selective metabolic aspects of bifidobacteria: carbohydrate metabolism, fatty acid biosynthesis and plasmid biology

    OpenAIRE

    O'Connell, Kerry Joan

    2014-01-01

    The gastrointestinal tract (GIT) is a diverse ecosystem, and is colonised by a diverse array of bacteria, of which bifidobacteria are a significant component. Bifidobacteria are Gram-positive, saccharolytic, non-motile, non-sporulating, anaerobic, Y-shaped bacteria, which possess a high GC genome content. Certain bifidobacteria possess the ability to produce conjugated linoleic acid (CLA) from linoleic acid (LA) by a biochemical pathway that is hypothesised to be achieved via a linoleic isome...

  1. Carbohydrates – Guidelines on Parenteral Nutrition, Chapter 5

    OpenAIRE

    Working group for developing the guidelines for parenteral nutrition of The German Association for Nutritional Medicine; Traeger, K.; Ockenga, J.; Kreymann, G.; Jauch, K.W.; Hauner, H.; Ebener, C.; Bolder, U

    2009-01-01

    The main role of carbohydrates in the human body is to provide energy. Carbohydrates should always be infused with PN (parenteral nutrition) in combination with amino acids and lipid emulsions to improve nitrogen balance. Glucose should be provided as a standard carbohydrate for PN, whereas the use of xylite is not generally recommended. Fructose solutions should not be used for PN. Approximately 60% of non-protein energy should be supplied as glucose with an intake of 3.0–3.5 g/kg body weigh...

  2. AspectKE*

    DEFF Research Database (Denmark)

    Yang, Fan; Masuhara, Hidehiko; Aotani, Tomoyuki; Nielson, Flemming; Nielson, Hanne Riis

    Enforcing security policies to distributed systems is difficult, in particular, when a system contains untrusted components. We designed AspectKE*, a distributed AOP language based on a tuple space, to tackle this issue. In AspectKE*, aspects can enforce access control policies that depend on...... demonstrate usefulness of AspectKE* through a security aspect for a distributed chat system....

  3. Crystallization of carbohydrate oxidase from Microdochium nivale.

    Science.gov (United States)

    Dusková, Jarmila; Dohnálek, Jan; Skálová, Tereza; Østergaard, Lars Henrik; Fuglsang, Claus Crone; Kolenko, Petr; Stepánková, Andrea; Hasek, Jindrich

    2009-06-01

    Microdochium nivale carbohydrate oxidase was produced by heterologous recombinant expression in Aspergillus oryzae, purified and crystallized. The enzyme crystallizes with varying crystal morphologies depending on the crystallization conditions. Several different crystal forms were obtained using the hanging-drop vapour-diffusion method, two of which were used for diffraction measurements. Hexagon-shaped crystals (form I) diffracted to 2.66 A resolution, with unit-cell parameters a = b = 55.7, c = 610.4 A and apparent space group P6(2)22. Analysis of the data quality showed almost perfect twinning of the crystals. Attempts to solve the structure by molecular replacement did not give satisfactory results. Recently, clusters of rod-shaped crystals (form II) were grown in a solution containing PEG MME 550. These crystals belonged to the monoclinic system C2, with unit-cell parameters a = 132.9, b = 56.6, c = 86.5 A, beta = 95.7 degrees . Data sets were collected to a resolution of 2.4 A. The structure was solved by the molecular-replacement method. Model refinement is currently in progress. PMID:19478452

  4. Carbohydrate degrading polypeptide and uses thereof

    Energy Technology Data Exchange (ETDEWEB)

    Sagt, Cornelis Maria Jacobus; Schooneveld-Bergmans, Margot Elisabeth Francoise; Roubos, Johannes Andries; Los, Alrik Pieter

    2015-10-20

    The invention relates to a polypeptide having carbohydrate material degrading activity which comprises the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 4, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 96% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 96% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.

  5. 2009 Cellulosomes, Cellulases & Other Carbohydrate Modifying Enzymes GRC

    Energy Technology Data Exchange (ETDEWEB)

    Harry Gilbert

    2009-07-26

    The 2009 Gordon Conference on Cellulosomes, Cellulases & Other Carbohydrate Modifying Enzymes will present cutting-edge research on the enzymatic degradation of cellulose and other plant cell wall polysaccharides. The Conference will feature a wide range of topics that includes the enzymology of plant structural degradation, regulation of the degradative apparatus, the mechanism of protein complex assembly, the genomics of cell wall degrading organisms, the structure of the substrate and the industrial application of the process particularly within the biofuel arena. Indeed the deployment of plant cell wall degrading enzymes in biofuel processes will be an important feature of the meeting. It should be emphasized that the 2009 Conference will be expanded to include, in addition to cellulase research, recent advances in other plant cell wall degrading enzymes, and contributions from people working on hemicellulases and pectinases will be particularly welcome. Invited speakers represent a variety of scientific disciplines, including biochemistry, structural biology, genetics and cell biology. The interplay between fundamental research and its industrial exploitation is a particularly important aspect of the meeting, reflecting the appointment of the chair and vice-chair from academia and industry, respectively. The meeting will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with more established figures in the field. Indeed, some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented. The Conference is likely to be heavily subscribed so we would recommend that you submit

  6. Systemic lupus erythematosus: Clinical and experimental aspects

    International Nuclear Information System (INIS)

    This text covers questions related to the history, etiology, pathogenesis, clinical aspects and therapy of systematic lupus erythematosus (SLE). Both animal models and human SLE are considered. With regard to basic science, concise information on cellular immunology, autoantibodies, viral aspects and molecular biology in SLE is provided. Clinical topics then deal with medical, dermatologic, neurologic, radiologic, pathologic, and therapeutic aspects. The book not only presents the most recent information on clinical and experimental insights, but also looks at future aspects related to the diagnosis and therapy of SLE

  7. Ototoxic Medications (Medication Effects)

    Science.gov (United States)

    ... effects of the medications on your hearing and balance systems. The team will discuss with you how these side effects will affect your quality of life. What are the effects I may notice from ... speech is affected. Balance problems can also occur as a result of ...

  8. Hydrogen and methane breath tests for evaluation of resistant carbohydrates

    DEFF Research Database (Denmark)

    Rumessen, J J

    1992-01-01

    This review considers in detail the background, principles, techniques, limitations and advantages of the hydrogen and methane breath tests. Resistant food carbohydrates, defined as dietary carbohydrates partly or totally escaping small intestinal assimilation, are fermented in the human colon....... Due to the large interindividual variations of hydrogen excretion, unabsorbable standards should be used. The intraindividual variations of H2 production/excretion and differences in fermentability of different carbohydrate substrates only allow for semiquantitative estimates of malabsorbed amounts of...... some carbohydrates. Methane breath tests may supplement the information gained from hydrogen measurements, but further evaluations are needed. The hydrogen breath technique is rapid, simple and non-invasive as well as non-radioactive. It may be carried out in a large number of intact individuals under...

  9. Synthesis of Heterocylic Compounds of Biological Interest from Carbohydrate Derivatives

    OpenAIRE

    M. F. Martinez Esperón; Fascio, M. L.; N. B. D’Accorso

    2000-01-01

    The synthesis of some isoxazolic compounds from carbohydrate derivatives is described. These products are obtained by 1,3-dipolar cycloaddition reaction and their functionalization leads to derivatives with potential biological activities.

  10. What I Need to Know about Carbohydrate Counting and Diabetes

    Science.gov (United States)

    ... zucchini. Foods that do not contain carbohydrates include meat, fish, and poultry; most types of cheese; nuts; ... Training & Career Development Research at NIDDK Research Resources Technology Advancement & Transfer Meetings & Events Health Information Health Topics ...

  11. Carbohydrate and steroid analysis by desorption electrospray ionization mass spectrometry.

    Science.gov (United States)

    Kauppila, Tiina J; Talaty, Nari; Jackson, Ayanna U; Kotiaho, Tapio; Kostiainen, Risto; Cooks, R Graham

    2008-06-21

    Desorption electrospray ionization mass spectrometry (DESI-MS) is applied to the analysis of carbohydrates and steroids; the detection limits are significantly improved by the addition of low concentrations of salts to the spray solvent. PMID:18535704

  12. Simple mucin-type carbohydrate antigens in major salivary glands

    DEFF Research Database (Denmark)

    Therkildsen, M H; Mandel, U; Thorn, J; Christensen, M; Dabelsteen, Erik

    1994-01-01

    Simple mucin-type carbohydrate antigens Tn, sialosyl-Tn and T are often markers of neoplastic transformation and have very limited expression in normal tissues. We performed an immunohistological study of simple mucin-type carbohydrate antigens, including H and A variants, with well-defined monoc......Simple mucin-type carbohydrate antigens Tn, sialosyl-Tn and T are often markers of neoplastic transformation and have very limited expression in normal tissues. We performed an immunohistological study of simple mucin-type carbohydrate antigens, including H and A variants, with well...... were predominantly observed in the cell cytoplasm, most often in the supranuclear area, suggesting localization to the Golgi region, whereas ductal contents were unstained. Mucous acinar cells expressed Tn, sialosyl-Tn, and H and A antigens, regardless of glandular location. Serous acinar cells, on the...

  13. Abstracts of papers of international scientific conference 'Fundamental and applied aspects of radiobiology: Biological effects of low doses and radioactive contamination of environment (Radioecological and medical biological consequences of the Chernobyl NPP accident)'

    International Nuclear Information System (INIS)

    The results of research works executed in Belarus, as well as in Ukraine and Russia, on various aspects of the Chernobyl problematic are given: radiation medicine and risks, radiobiological effects and their forecasting, radioecology and agricultural radiology, decontamination and radioactive wastes management, socio economic and psychological problems caused by the Chernobyl NPP accident

  14. Abortion - medical

    Science.gov (United States)

    Therapeutic medical abortion; Elective medical abortion; Induced abortion; Nonsurgical abortion ... A medical, or nonsurgical, abortion can be done within 7 weeks from the first day of the woman's last ...

  15. Carbohydrate vaccines: developing sweet solutions to sticky situations?

    OpenAIRE

    Astronomo, Rena D.; Burton, Dennis R.

    2010-01-01

    The realm of carbohydrate vaccines has expanded far beyond the capsular polysaccharides of bacterial pathogens to include a diverse collection of targets representing nearly every biological kingdom. Recent technological advances in glycobiology and glycochemistry are paving the way for a new era in carbohydrate vaccine design enabling greater efficiency in the identification, synthesis and evaluation of unique glycan epitopes found on a plethora of pathogens and malignant cells. This article...

  16. Synthesis of carbohydrate-scaffolded thymine glycoconjugates to organize multivalency

    OpenAIRE

    Anna K. Ciuk; Lindhorst, Thisbe K

    2015-01-01

    Multivalency effects are essential in carbohydrate recognition processes as occurring on the cell surface. Thus many synthetic multivalent glycoconjugates have been developed as important tools for glycobiological research. We are expanding this collection of molecules by the introduction of carbohydrate-scaffolded divalent glycothymine derivatives that can be intramolecularily dimerized by [2 + 2] photocycloaddition. Thus, thymine functions as a control element that allows to restrict the co...

  17. Co-occurrence of carbohydrate malabsorption and primary epiploic appendagitis

    OpenAIRE

    Schnedl, Wolfgang J.; Kalmar, Peter; Mangge, Harald; Krause, Robert; Wallner-Liebmann, Sandra J.

    2015-01-01

    Unspecific abdominal complaints including bloating and irregular bowel movements may be caused by carbohydrate malabsorption syndromes, e.g., lactose and fructose malabsorption. These symptoms were investigated with hydrogen (H2) breath tests and correlated to carbohydrate malabsorption. During performing these H2-breath tests the patient presented with an acute, localized, non-migratory pain in the left lower abdominal quadrant. Primary epiploic appendagitis is a rare cause of abdominal acut...

  18. The case for low carbohydrate diets in diabetes management

    OpenAIRE

    McFarlane Samy I; Arora Surender K

    2005-01-01

    Abstract A low fat, high carbohydrate diet in combination with regular exercise is the traditional recommendation for treating diabetes. Compliance with these lifestyle modifications is less than satisfactory, however, and a high carbohydrate diet raises postprandial plasma glucose and insulin secretion, thereby increasing risk of CVD, hypertension, dyslipidemia, obesity and diabetes. Moreover, the current epidemic of diabetes and obesity has been, over the past three decades, accompanied by ...

  19. Carbohydrate catabolic diversity of bifidobacteria and lactobacilli of human origin.

    Science.gov (United States)

    McLaughlin, Heather P; Motherway, Mary O'Connell; Lakshminarayanan, Bhuvaneswari; Stanton, Catherine; Paul Ross, R; Brulc, Jennifer; Menon, Ravi; O'Toole, Paul W; van Sinderen, Douwe

    2015-06-16

    Because increased proportions of particular commensal bacteria such as bifidobacteria and lactobacilli have been linked to human health through a variety of mechanisms, there is corresponding interest in identifying carbohydrates that promote growth and metabolic activity of these bacteria. We evaluated the ability of 20 carbohydrates, including several commercially available carbohydrates that are sold as prebiotic ingredients, to support growth of 32 human-derived isolates belonging to the genera Bifidobacterium and Lactobacillus, including those isolated from healthy elderly subjects. In general, bifidobacterial strains were shown to display more diverse carbohydrate utilization profiles compared to the tested Lactobacillus species, with several bifidobacterial strains capable of metabolizing xylo-oligosaccharide (XOS), arabinoxylan, maltodextrin, galactan and carbohydrates containing fructo-oligosaccharide (FOS) components. In contrast, maltodextrin, galactan, arabinogalactan and galactomannan did not support robust growth (≥0.8 OD600 nm) of any of the Lactobacillus strains assessed. Carbohydrate fermentation was variable among strains tested of the same species for both genera. This study advances our knowledge of polysaccharide utilization by human gut commensals, and provides information for the rational design of selective prebiotic food ingredients. PMID:25817019

  20. Cause of impaired carbohydrate metabolism in hyperthyroidism

    International Nuclear Information System (INIS)

    Hyperthyroidism (HT) affects glucose metabolism in various ways. The role of insulin, glucagon and growth-hormone (GH) was determined. After glucose loading the insulin response is weaker in HT than in euthyroid subjects. Enhanced degradation of insulin has been reported. It is suggested that in HT the serum insulin concentration declines at a slightly accelerated rate. In HT the deranged carbohydrate metabolism might be a consequence of altered tissue sensitivity to insulin. To elucidate this problem insulin receptors on erythrocytes obtained from hyperthyroid women were investigated. The maximal specific binding of 125I-insulin to RBC of hyperthyroid patients was decreased and the analysis refers to a decreased receptor concentration in RBC. The nature of glucagon secretion and its influence on glucose metabolism in HT was investigated. The basal plasma glucagon is elevated in hyperthyroid patients. The suppression of glucagon secretion induced by an oral glucose loading was of significantly lesser degree in hyperthyroid patients than in controls. Applying the erythrocyte receptor assay a decreased specific binding of 125I-glucagon to RBC of hyperthyroid patients has been found and data indicate a significantly less glucagon receptor concentration in thyrotoxicosis. Physiological elevations of serum GH levels led to a significant impairment of glucose metabolism. Beside the GH-RH and somatostatin, the dopaminergic neurotransmitter system participates in the regulation of GH secretion too. It has been demonstrated that after administration of the dopamine agonist l-dopa the GH response was weaker in HT than in controls. This indicates that in thyrotoxicosis the GH secretion can not be stimulated in such a degree as in euthyroidism. (author)

  1. Carbohydrate Mimetic Peptides Augment Carbohydrate-Reactive Immune Responses in the Absence of Immune Pathology

    Energy Technology Data Exchange (ETDEWEB)

    Hennings, Leah; Artaud, Cecile; Jousheghany, Fariba; Monzavi-Karbassi, Behjatolah; Pashov, Anastas; Kieber-Emmons, Thomas, E-mail: tke@uams.edu [Winthrop P. Rockefeller Cancer Institute and Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 (United States)

    2011-11-11

    Among the most challenging of clinical targets for cancer immunotherapy are Tumor Associated Carbohydrate Antigens (TACAs). To augment immune responses to TACA we are developing carbohydrate mimetic peptides (CMPs) that are sufficiently potent to activate broad-spectrum anti-tumor reactivity. However, the activation of immune responses against terminal mono- and disaccharide constituents of TACA raises concerns regarding the balance between “tumor destruction” and “tissue damage”, as mono- and disaccharides are also expressed on normal tissue. To support the development of CMPs for clinical trial testing, we demonstrate in preclinical safety assessment studies in mice that vaccination with CMPs can enhance responses to TACAs without mediating tissue damage to normal cells expressing TACA. BALB/c mice were immunized with CMPs that mimic TACAs reactive with Griffonia simplicifolia lectin 1 (GS-I), and tissue reactivity of serum antibodies were compared with the tissue staining profile of GS-I. Tissues from CMP immunized mice were analyzed using hematoxylin and eosin stain, and Luxol-fast blue staining for myelination. Western blots of membranes from murine mammary 4T1 cells, syngeneic with BALB/c mice, were also compared using GS-I, immunized serum antibodies, and naive serum antibodies. CMP immunization enhanced glycan reactivities with no evidence of pathological autoimmunity in any immunized mice demonstrating that tissue damage is not an inevitable consequence of TACA reactive responses.

  2. Carbohydrate Mimetic Peptides Augment Carbohydrate-Reactive Immune Responses in the Absence of Immune Pathology

    International Nuclear Information System (INIS)

    Among the most challenging of clinical targets for cancer immunotherapy are Tumor Associated Carbohydrate Antigens (TACAs). To augment immune responses to TACA we are developing carbohydrate mimetic peptides (CMPs) that are sufficiently potent to activate broad-spectrum anti-tumor reactivity. However, the activation of immune responses against terminal mono- and disaccharide constituents of TACA raises concerns regarding the balance between “tumor destruction” and “tissue damage”, as mono- and disaccharides are also expressed on normal tissue. To support the development of CMPs for clinical trial testing, we demonstrate in preclinical safety assessment studies in mice that vaccination with CMPs can enhance responses to TACAs without mediating tissue damage to normal cells expressing TACA. BALB/c mice were immunized with CMPs that mimic TACAs reactive with Griffonia simplicifolia lectin 1 (GS-I), and tissue reactivity of serum antibodies were compared with the tissue staining profile of GS-I. Tissues from CMP immunized mice were analyzed using hematoxylin and eosin stain, and Luxol-fast blue staining for myelination. Western blots of membranes from murine mammary 4T1 cells, syngeneic with BALB/c mice, were also compared using GS-I, immunized serum antibodies, and naive serum antibodies. CMP immunization enhanced glycan reactivities with no evidence of pathological autoimmunity in any immunized mice demonstrating that tissue damage is not an inevitable consequence of TACA reactive responses

  3. An introduction to medical statistics

    International Nuclear Information System (INIS)

    This textbook teaches all aspects and methods of biometrics as a field of concentration in medical education. Instrumental interpretations of the theory, concepts and terminology of medical statistics are enhanced by numerous illustrations and examples. With problems, questions and answers. (orig./CB)

  4. Assessing the Impacts of Low Carbohydrate Related Health Information on the Market Demand for US Vegetables

    OpenAIRE

    Paudel, Laxmi; Adhikari, Murali; Houston, Jack E.

    2005-01-01

    An Almost Ideal Demand System was estimated to examine the impacts of low carbohydrate information on the market demand for US vegetables. Analysis was extended to examine the performance of alternative carbohydrate information indexes. Study shows significant robust impacts of low carbohydrate information across all included vegetables. Results favor the general and weighted carbohydrate information index.

  5. Modified carbohydrate-chitosan compounds, methods of making the same and methods of using the same

    Energy Technology Data Exchange (ETDEWEB)

    Venditti, Richard A; Pawlak, Joel J; Salam, Abdus; El-Tahlawy, Khaled Fathy

    2015-03-10

    Compositions of matter are provided that include chitosan and a modified carbohydrate. The modified carbohydrate includes a carbohydrate component and a cross linking agent. The modified carbohydrate has increased carboxyl content as compared to an unmodified counterpart carbohydrate. A carboxyl group of the modified carbohydrate is covalently bonded with an amino group of chitosan. The compositions of matter provided herein may include cross linked starch citrate-chitosan and cross linked hemicellulose citrate-chitosan, including foams thereof. These compositions yield excellent absorbency and metal chelation properties. Methods of making cross linked modified carbohydrate-chitosan compounds are also provided.

  6. Nutritional aspects of irradiated shrimp

    International Nuclear Information System (INIS)

    Data available in the literature on the nutritional aspects of irradiated shrimp are reviewed and the indication is that irradiation of shrimp at doses up to about 3.2 kGy does not significantly affect the levels of its protein, fat, carbohydrate and ash. There are no reports on the effect of irradiation of shrimp above 3.2 kGy on these components. Limited information available indicates that there are some minor changes in the fatty acid composition of shrimp as a result of irradiation. Irradiation also causes some changes in the amino acid composition of shrimp; similar changes occur due to canning and hot-air drying. Some of the vitamins in shrimp, such as thiamine, are lost as a result of irradiation but the loss is less extensive than in thermally processed shrimp. Protein quality of shrimp, based on the growth of rats as well as that of Tetrahymena pyriformis, is not affected by irradiation. No adverse effects attributed to irradiation were found either in short-term or long-term animal feeding tests

  7. The impact of low-carbohydrate diet on glycemic control in Native Americans

    Directory of Open Access Journals (Sweden)

    Khairi S

    2015-08-01

    Full Text Available Shafaq Khairi,1 Babak Torabi Sagvand,2 Syed Kamal Nasser3 1Southeastern Regional Physician Services, Lumberton, NC, 2Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Southeastern Regional Medical Center, Lumberton, NC, USA Abstract: Many studies have shown that a low-carbohydrate diet (LCD is a safe and effective intervention to improve glycemic control. However, published data are limited regarding the use of carbohydrate restriction in the treatment and prevention of type 2 diabetes mellitus (DM in the Native Americans, in a real-world clinical practice setting. We evaluated the efficacy of an LCD on 50 obese Native Americans with either type 2 DM or impaired fasting blood glucose (IFG in a primary care/obesity medicine practice. The primary intervention was an LCD defined as an intake of <20 g of carbohydrates per day. The intervention involved providing an educational handout and behavioral counseling assisted by a dedicated weight loss coordinator. We evaluated the effects of this intervention on hemoglobin A1c, body weight, blood pressure, and lipid parameters. The subjects were evaluated at baseline and 6 months. The subjects underwent additional safety and counseling visits throughout the study. Subjects were considered completers if they had baseline and 6-month measurements. The mean age was 55.0±10.9 years, and 66.7% were female. Subjects had significant improvements in hemoglobin A1c (-1.4%±0.9%, in subjects with DM, P<0.0001, fasting blood glucose (-15±4.9 mg/dL, in subjects with IFG, P<0.0001, and body mass index (-4.0±1.7 kg/m2, P<0.0001. An LCD can lead to clinically and statistically significant improvement in glycemic control and body weight among obese subjects with type 2 DM or IFG over a 6-month period. The results suggest that carbohydrate restriction can be an effective real-world intervention in a primarily Native American clinical practice. However, further studies are needed

  8. TRANSLATION PROBLEMS IN MEDICAL TEXTS

    OpenAIRE

    OĞUZ, Derya

    2014-01-01

    In this study, our aim was to emphasize the fact that the translation of medical texts represents a special area in translation, and that the most important aspect of medical text translation is being aware of the purpose and intent behind these translations. Medical text translation is not an area in which any person engaged in translation can work effectively. The translator first needs to have a considerable scientific background and experience. The translator’s task, in this context, is t...

  9. Carbohydrate supplementation and prolonged intermittent high-intensity exercise in adolescents: research findings, ethical issues and suggestions for the future.

    Science.gov (United States)

    Phillips, Shaun M

    2012-10-01

    In the last decade, research has begun to investigate the efficacy of carbohydrate supplementation for improving aspects of physical capacity and skill performance during sport-specific exercise in adolescent team games players. This research remains in its infancy, and further study would be beneficial considering the large youth population actively involved in team games. Literature on the influence of carbohydrate supplementation on skill performance is scarce, limited to shooting accuracy in adolescent basketball players and conflicting in its findings. Between-study differences in the exercise protocol, volume of fluid and carbohydrate consumed, use of prior fatiguing exercise and timing of skill tests may contribute to the different findings. Conversely, initial data supports carbohydrate supplementation in solution and gel form for improving intermittent endurance running capacity following soccer-specific shuttle running. These studies produced reliable data, but were subject to limitations including lack of quantification of the metabolic response of participants, limited generalization of data due to narrow participant age and maturation ranges, use of males and females within the same sample and non-standardized pre-exercise nutritional status between participants. There is a lack of consensus regarding the influence of frequently consuming carbohydrate-containing products on tooth enamel erosion and the development of obesity or being overweight in adolescent athletes and non-athletes. These discrepancies mean that the initiation or exacerbation of health issues due to frequent consumption of carbohydrate-containing products by adolescents cannot be conclusively refuted. Coupled with the knowledge that consuming a natural, high-carbohydrate diet -3-8 hours before exercise can significantly alter substrate use and improve exercise performance in adults, a moral and ethical concern is raised regarding the direction of future research in order to further

  10. Effect of carbohydrate restriction and high carbohydrates diets on men with chemical diabetes.

    Science.gov (United States)

    Anderson, J W

    1977-03-01

    The influence of low carbohydrate (CHO) diets, starvation, and high CHO diets on glucose tolerance tests (GTT) and plasma insulin response of men with chemical diabetes was studied. The GTT and insulin responses of these seven lean diabetic men were unchanged when the carbohydrate content of the diet was reduced from 44 to 20% of calories. After a 48-hr fast a significant deterioration of the GTT was observed in these diabetic men but the percentage change was identical to that reported previously for normal men. Thus these studies indicate that changes in glucose mtes are quite similar to those reported previously for normal men. The fasting plasma glucose values of seven lean and four obese men with chemical diabetes were significantly lower after one week on a 75% CHO diet than values on a 44% CHO diet. The 75% CHO diet also was accompanied by slight improvements in the oral and intravenous GTT and by slightly lower plasma insulin responses. The improvement in glucose metabolism on high CHO diets appears to results from increased insulin sensitivity. Serum triglyceride values were approximately 55% higher on the 75% CHO diet than values on the 44% CHO diet for the 11 men but these differences were not statistically significant. These studies support previous observations and suggest that high CHO diets may be beneficial in the management of certain diabetic patients. However, further studies are required to determine the long-term effects of high CHO diets containing natural foods on the glucose and lipid metabolism of diabetic patients. PMID:842491

  11. Medicolegal aspects in gastroenterology

    OpenAIRE

    Krstić M.; Savić S.; Kovačević N.; Alempijević T.; Alempijević Đ.

    2007-01-01

    Introduction: Medical practice is under continual public scrutiny. There are increasing concerns on medical malpractice and its consequences - further deterioration of health and death. Public criticism of medical practice very often outrageous, but sometimes medical negligence is obvious. Aim of the study: We are presenting basic medicolegal analysis of causation in cases of medical malpractice with subsequent fatal outcome. Case study: We are reporting on two cases from archives of Institut...

  12. Expression analysis of carbohydrate antigens in ductal carcinoma in situ of the breast by lectin histochemistry

    Directory of Open Access Journals (Sweden)

    Kieber-Emmons Thomas

    2008-05-01

    Full Text Available Abstract Background The number of breast cancer patients diagnosed with ductal carcinoma in situ (DCIS continues to grow. Laboratory and clinical data indicate that DCIS can progress to invasive disease. Carbohydrate-mediated cell-cell adhesion and tumor-stroma interaction play crucial roles in tumorigenesis and tumor aggressive behavior. Breast carcinogenesis may reflect quantitative as well as qualitative changes in oligosaccharide expression, which may provide a useful tool for early detection of breast cancer. Because tumor-associated carbohydrate antigens (TACA are implicated in tumor invasion and metastasis, the purpose of this study was to assess the expression of selected TACA by lectin histochemistry on DCIS specimens from the archival breast cancer tissue array bank of the University of Arkansas for Medical Sciences. Methods For detection of TACA expression, specimens were stained with Griffonia simplicifolia lectin-I (GS-I and Vicia vilosa agglutinin (VVA. We studied associations of lectin reactivity with established prognostic factors, such as tumor size, tumor nuclear grade, and expression of Her-2/neu, p53 mutant and estrogen and progesterone receptors. Results We observed that both lectins showed significant associations with nuclear grade of DCIS. DCIS specimens with nuclear grades II and III showed significantly more intense reactivity than DCIS cases with nuclear grade I to GS-1 (Mean-score chi-square = 17.60, DF = 2; P = 0.0002 and VVA (Mean-score chi-square = 15.72, DF = 2; P = 0.0004. Conclusion The results suggest that the expression of VVA- and GS-I-reactive carbohydrate antigens may contribute to forming higher grade DCIS and increase the recurrence risk.

  13. Expression analysis of carbohydrate antigens in ductal carcinoma in situ of the breast by lectin histochemistry

    International Nuclear Information System (INIS)

    The number of breast cancer patients diagnosed with ductal carcinoma in situ (DCIS) continues to grow. Laboratory and clinical data indicate that DCIS can progress to invasive disease. Carbohydrate-mediated cell-cell adhesion and tumor-stroma interaction play crucial roles in tumorigenesis and tumor aggressive behavior. Breast carcinogenesis may reflect quantitative as well as qualitative changes in oligosaccharide expression, which may provide a useful tool for early detection of breast cancer. Because tumor-associated carbohydrate antigens (TACA) are implicated in tumor invasion and metastasis, the purpose of this study was to assess the expression of selected TACA by lectin histochemistry on DCIS specimens from the archival breast cancer tissue array bank of the University of Arkansas for Medical Sciences. For detection of TACA expression, specimens were stained with Griffonia simplicifolia lectin-I (GS-I) and Vicia vilosa agglutinin (VVA). We studied associations of lectin reactivity with established prognostic factors, such as tumor size, tumor nuclear grade, and expression of Her-2/neu, p53 mutant and estrogen and progesterone receptors. We observed that both lectins showed significant associations with nuclear grade of DCIS. DCIS specimens with nuclear grades II and III showed significantly more intense reactivity than DCIS cases with nuclear grade I to GS-1 (Mean-score chi-square = 17.60, DF = 2; P = 0.0002) and VVA (Mean-score chi-square = 15.72, DF = 2; P = 0.0004). The results suggest that the expression of VVA- and GS-I-reactive carbohydrate antigens may contribute to forming higher grade DCIS and increase the recurrence risk

  14. Phase transformation of goethite into magnetite by reducing with carbohydrates

    Directory of Open Access Journals (Sweden)

    Dudchenko N.O.

    2015-09-01

    Full Text Available Phase transformations of synthetic goethite and goethite ore from Kryvyi Rih region by reducing with different carbohydrates (starch, glucose, fructose, sucrose and ascorbic acid were investigated by thermomagnetic analysis. Thermomagnetic analysis was carried-out using laboratory device that allows automatic registration of sample magnetization with the temperature (the rate of sample heating/cooling was 65-80°/min. The reduction reaction of synthetic goethite for all carbohydrates starts at the temperature of ~250°C while reduction of goethite ore for all carbohydrates starts at the temperature of ~450°C. We could relate this increasing of reduction start temperature with shielding effect of admixtures in the ore. Reduction of synthetic goethite at this temperature range leads to formation of magnetic phase with saturation magnetisation ~70 A*m2/kg. At the same time, reduction of goethite ore leads to formation of magnetic phase with saturation magnetisation ~25 A*m2/kg. One could attribute this decreased value of saturation magnetisation to the presence of other minerals (quartz, etc. in the ore. It was shown by X-Ray Diffraction method that goethite completely transforms into magnetite under heating with different carbohydrates up to 650°C. All carbohydrates reduce goethite to magnetite.

  15. Self medication practices among medical students of a private institute

    Directory of Open Access Journals (Sweden)

    Arti A Kasulkar

    2015-01-01

    Full Text Available The study was undertaken to evaluate various aspects of self-medication in medical students. A prospective, cross-sectional, questionnaire-based study was carried out among 488 medical students selected by simple random sampling from January 2013 to June 2013. Data was collected and analyzed for counts and percentage. Students reported self-medication in the preceding one year was 71.7 % and the prevalence was more in final year students. Fever and headache were the most frequently reported illnesses, commonly used drugs were antipyretics and analgesics, obtained information through reading material, and reasons quoted were minor ailments and quick relief. Majority students agreed that medical knowledge is necessary for administration of medicine by self. Self-medication is highly prevalent in medical students, which is quite alarming.

  16. Osteoporosis, Global and Iranian Aspects

    Directory of Open Access Journals (Sweden)

    B Larijani

    2004-03-01

    Full Text Available Osteoporosis, characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enlarged bone fragility and a consequent increase in fracture risk is a leading cause of morbidity and mortality in elderly people. The mortality rate in elderly persons with hip fracture approaches 20%. Half of them will be disabled in the remained life. Iranian Multicenter Osteoporosis Study (IMOS developed by Endocrinology and Metabolism Research Center of Tehran University of Medical Sciences (EMRC-TUMS and Ministry of Health and Medical Education in 2000. The aim of this study with more than 6000 participitants, was to determine normal range of BMD in Iranian population and assessing the current calcium and vitamin D status in Iran. The results were used for determining the normrmogram of BMD in Iranians and prevalence of Vit-D deficinecy among them. This document outlines all aspects of osteoporosis including risk factors, diagnosis, treatment and prevention of osteoporosis.

  17. Osteoporosis, Global and Iranian Aspects

    Directory of Open Access Journals (Sweden)

    B Larijani

    2004-11-01

    Full Text Available Osteoporosis, characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enlarged bone fragility and a consequent increase in fracture risk is a leading cause of morbidity and mortality in elderly people. The mortality rate in elderly persons with hip fracture approaches 20%. Half of them will be disabled in the remained life. Iranian Multicenter Osteoporosis Study (IMOS developed by Endocrinology and Metabolism Research Center of Tehran University of Medical Sciences (EMRC-TUMS and Ministry of Health and Medical Education in 2000. The aim of this study with more than 6000 participitants, was to determine normal range of BMD in Iranian population and assessing the current calcium and vitamin D status in Iran. The results were used for determining the normrmogram of BMD in Iranians and prevalence of Vit-D deficinecy among them. This document outlines all aspects of osteoporosis including risk factors, diagnosis, treatment and prevention of osteoporosis.

  18. Stable-isotope-labeled carbohydrates and nucleosides: Synthesis and applications in chemistry and biology

    Energy Technology Data Exchange (ETDEWEB)

    Serianni, A.S. [Univ. of Notre Dame, IN (United States)

    1994-12-01

    Carbohydrates play important roles in many key biochemical processes in living cells. For example, they are metabolized to produce energy, mediate cell-cell recognition, and play an indirect role (as constituents of DNA and RNA) in DNA replication, RNA transcription, and protein synthesis. These roles, and others of comparable biochemical significance, have been studied to varying extends with the use of stable isotopically labeled molecules, usually in conjunction with NMR spectroscopy and/or mass spectrometry. For example, carbohydrate metabolism has been monitored in vitro and in vivo with the use of isotopically labeled compounds. Molecular aspects of cell-cell recognition, mediated by cell-surface glycoproteins and glycolipids, have been probed through NMR studies of isotopically labeled oligosaccharides. More recently, the solution behavior of DNA and RNA has been examined through the use of labeled oligonucleotides. In all of these pursuits, the effort and expense to prepare labeled molecules, both of which can be substantial, are more than offset by the wealth of information derived from these studies. This information often cannot be accessed, or can be accessed only with great difficulty, using natural (unlabeled) compounds.

  19. Glycoprotein Biochemistry (Biosynthesis)--A Vehicle for Teaching Many Aspects of Biochemistry and Molecular Biology.

    Science.gov (United States)

    Cole, Clair R.; Smith, Christopher A.

    1990-01-01

    Information about the biosynthesis of the carbohydrate portions or glycans of glycoproteins is presented. The teaching of glycosylation can be used to develop and emphasize many general aspects of biosynthesis, in addition to explaining specific biochemical and molecular biological features associated with producing the oligosaccharide portions of…

  20. Carbohydrate-Related Inhibitors of Dengue Virus Entry

    Directory of Open Access Journals (Sweden)

    Takashi Suzuki

    2013-02-01

    Full Text Available Dengue virus (DENV, which is transmitted by Aedes mosquitoes, causes fever and hemorrhagic disorders in humans. The virus entry process mediated through host receptor molecule(s is crucial for virus propagation and the pathological progression of dengue disease. Therefore, elucidation of the molecular mechanisms underlying virus entry is essential for an understanding of dengue pathology and for the development of effective new anti-dengue agents. DENV binds to its receptor molecules mediated through a viral envelope (E protein, followed by incorporation of the virus-receptor complex inside cells. The fusion between incorporated virus particles and host endosome membrane under acidic conditions is mediated through the function of DENV E protein. Carbohydrate molecules, such as sulfated glycosaminoglycans (GAG and glycosphingolipids, and carbohydrate-recognition proteins, termed lectins, inhibit virus entry. This review focuses on carbohydrate-derived entry inhibitors, and also introduces functionally related compounds with similar inhibitory mechanisms against DENV entry.

  1. Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry.

    Science.gov (United States)

    Cipolla, Laura; La Ferla, Barbara; Airoldi, Cristina; Zona, Cristiano; Orsato, Alexandre; Shaikh, Nasrin; Russo, Laura; Nicotra, Francesco

    2010-04-01

    Several glycoprocessing enzymes and glycoreceptors have been recognized as important targets for therapeutic intervention. This concept has inspired the development of important classes of therapeutics, such as anti-influenza drugs inhibiting influenza virus neuraminidase, anti-inflammatory drugs targeting lectin-sialyl-Lewis X interaction and glycosidase inhibitors against HIV, Gaucher's disease, hepatitis and cancer. These therapeutics are mainly carbohydrate mimics in which proper modifications permit stronger interactions with the target protein, higher stability, better pharmacokinetic properties and easier synthesis. Furthermore, the conformational rigidity and polyfunctionality of carbohydrates stimulate their use as scaffolds for the generation of libraries by combinatorial decoration with different pharmacophores. This mini-review will present examples of how to exploit carbohydrates mimics and scaffolds in drug research. PMID:21426009

  2. [Food intolerances caused by enzyme defects and carbohydrate malassimiliations : Lactose intolerance and Co].

    Science.gov (United States)

    Schäfer, Christiane

    2016-06-01

    Apart from allergic conditions, carbohydrate malassimiliations (sugar metabolism disorders) are classified within the group of food intolerances. These dose-dependent, yet non-immunological reactions require gastroenterological or internal diagnosis following nutritional therapy. Intolerances to carbohydrates such as lactose (milk sugar) and fructose (fruit sugar) in addition to sugar alcohols (sorbitol, mannitol, lactitol etc.) have been gaining increasing attention in recent decades as they are the cause of a wide range of gastrointestinal symptoms. There are currently various options for both diagnosis and therapy that differ notably in terms of effort, costs, and efficiency. Nutritional change and patient education are the bases of therapy. Non-observance of the trigger will result in increasing complaints and possibly even more infections, e.g., diverticula, rectal disorders, bacterial miscolonization, bile acid malabsorption). For an optimal therapy, the following sugar metabolism disorders have to be differentiated: hypolactasia versus lactose maldigestion, fructose malabsorption versus fructose overload, combined lactose and fructose intolerance, and isolated adverse reactions against sorbitol.For the medical conditions listed above, a three- or four-stage treatment regimen is recommended. Extensive dietary restrictions with regard to the relevant sugar, except for lactose, should not be maintained over a longer period of time. PMID:27188621

  3. Microalgal carbohydrates. An overview of the factors influencing carbohydrates production, and of main bioconversion technologies for production of biofuels

    Energy Technology Data Exchange (ETDEWEB)

    Markou, Giorgos; Georgakakis, Dimitris [Agricultural Univ. of Athens (Greece). Dept. of Natural Resources Management and Agricultural Engineering; Angelidaki, Irini [Technical Univ. of Denmark, Lyngby (Denmark). Dept. of Environmental Engineering

    2012-11-15

    Microalgal biomass seems to be a promising feedstock for biofuel generation. Microalgae have relative high photosynthetic efficiencies, high growth rates, and some species can thrive in brackish water or seawater and wastewater from the food- and agro-industrial sector. Today, the main interest in research is the cultivation of microalgae for lipids production to generate biodiesel. However, there are several other biological or thermochemical conversion technologies, in which microalgal biomass could be used as substrate. However, the high protein content or the low carbohydrate content of the majority of the microalgal species might be a constraint for their possible use in these technologies. Moreover, in the majority of biomass conversion technologies, carbohydrates are the main substrate for production of biofuels. Nevertheless, microalgae biomass composition could be manipulated by several cultivation techniques, such as nutrient starvation or other stressed environmental conditions, which cause the microalgae to accumulate carbohydrates. This paper attempts to give a general overview of techniques that can be used for increasing the microalgal biomass carbohydrate content. In addition, biomass conversion technologies, related to the conversion of carbohydrates into biofuels are discussed. (orig.)

  4. Characterization of carbohydrate-protein matrices for nutrient delivery.

    Science.gov (United States)

    Zhou, Yankun; Roos, Yrjö H

    2011-05-01

    Amorphous carbohydrates may show glass transition and crystallization as a result of thermal or water plasticization. Proteins often affect the state transitions of carbohydrates in carbohydrate-protein systems. Water sorption behavior and effects of water on glass transition and crystallization in freeze-dried lactose, trehalose, lactose-casein (3: 1), lactose-soy protein isolate (3:1), trehalose-casein (3:1), and trehalose-soy protein isolate (3:1) systems were studied. Water sorption was determined gravimetrically as a function of time, and Brunauer-Emmett-Teller (BET) and Guggenheim-Anderson-de Boer (GAB) models were fitted to the experimental data. Glass transition temperature (T(g)) and instant crystallization temperature (T(ic)) in anhydrous and water plasticized systems were measured using differential scanning calorimetry (DSC). The Gordon-Taylor equation was used to model water content dependence of the T(g) values. The critical water content and water activity (a(w)) at 24 °C were calculated and crystallization of lactose and trehalose in the systems was followed at and above 0.54 a(w). Carbohydrate-protein systems showed higher amounts of sorbed water and less rapid sugar crystallization than pure sugars. A greater sugar crystallization delay was found in carbohydrate-casein systems than in carbohydrate-soy protein isolate systems. The T(g) and T(ic) values decreased with increasing water content and a(w). However, higher T(ic) values for lactose-protein systems were found than for lactose at the same a(w). Trehalose showed lower T(ic) value than lactose at 0.44 a(w) but no instant crystallization was measured below 0.44 a(w). State diagrams for each system are useful in selecting processing parameters and storage conditions in nutrient delivery applications. PMID:22417357

  5. Vina-Carb: Improving Glycosidic Angles during Carbohydrate Docking.

    Science.gov (United States)

    Nivedha, Anita K; Thieker, David F; Makeneni, Spandana; Hu, Huimin; Woods, Robert J

    2016-02-01

    Molecular docking programs are primarily designed to align rigid, drug-like fragments into the binding sites of macromolecules and frequently display poor performance when applied to flexible carbohydrate molecules. A critical source of flexibility within an oligosaccharide is the glycosidic linkages. Recently, Carbohydrate Intrinsic (CHI) energy functions were reported that attempt to quantify the glycosidic torsion angle preferences. In the present work, the CHI-energy functions have been incorporated into the AutoDock Vina (ADV) scoring function, subsequently termed Vina-Carb (VC). Two user-adjustable parameters have been introduced, namely, a CHI- energy weight term (chi_coeff) that affects the magnitude of the CHI-energy penalty and a CHI-cutoff term (chi_cutoff) that negates CHI-energy penalties below a specified value. A data set consisting of 101 protein-carbohydrate complexes and 29 apoprotein structures was used in the development and testing of VC, including antibodies, lectins, and carbohydrate binding modules. Accounting for the intramolecular energies of the glycosidic linkages in the oligosaccharides during docking led VC to produce acceptable structures within the top five ranked poses in 74% of the systems tested, compared to a success rate of 55% for ADV. An enzyme system was employed in order to illustrate the potential application of VC to proteins that may distort glycosidic linkages of carbohydrate ligands upon binding. VC represents a significant step toward accurately predicting the structures of protein-carbohydrate complexes. Furthermore, the described approach is conceptually applicable to any class of ligands that populate well-defined conformational states. PMID:26744922

  6. Medical Illustration

    Science.gov (United States)

    ... and authentic illustrations used in the publication of medical books, journals, films, videotapes, exhibits, posters, wall charts, and computer programs. A medical illustrator may also work as a member of ...

  7. Medical Identity

    DEFF Research Database (Denmark)

    Musaeus, Peter

    2015-01-01

    Purpose: To examine philosophical stances underpinning medical identity and assess the conceptual relationship between physician, medical practice and culture. Argument: Medical identity is about the ideals and moral positions that physicians take when justifying themselves. Medical identity is the...... hedonistic versus sentimentalist approaches to medical identity. The sociocultural philosophical analysis of medical identity can shed light on what it means conceptually for a physician to harbor beliefs associated with him/her being taken to be an autonomous professional. It is important because it touches...... on the meaning of being a compassionate, good and skilled physician, making its relevance to person-centered medicine self-evident. Conclusion: Medical identity should be analyzed with reference to literature, philosophy and medical practice in order for the physician to exercise a reflective...

  8. Medical Management

    Science.gov (United States)

    ... email share facebook twitter google plus linkedin Medical Management Although there’s no cure for CMT, there are ... individualized physical therapy program. For more on medical management of CMT, see Surgery Sometimes, Bracing Often, Caution ...

  9. Diagnosing and Treating Intolerance to Carbohydrates in Children.

    Science.gov (United States)

    Berni Canani, Roberto; Pezzella, Vincenza; Amoroso, Antonio; Cozzolino, Tommaso; Di Scala, Carmen; Passariello, Annalisa

    2016-03-01

    Intolerance to carbohydrates is relatively common in childhood, but still poorly recognized and managed. Over recent years it has come to the forefront because of progresses in our knowledge on the mechanisms and treatment of these conditions. Children with intolerance to carbohydrates often present with unexplained signs and symptoms. Here, we examine the most up-to-date research on these intolerances, discuss controversies relating to the diagnostic approach, including the role of molecular analysis, and provide new insights into modern management in the pediatric age, including the most recent evidence for correct dietary treatment. PMID:26978392

  10. Synthesis of carbohydrate-scaffolded thymine glycoconjugates to organize multivalency.

    Science.gov (United States)

    Ciuk, Anna K; Lindhorst, Thisbe K

    2015-01-01

    Multivalency effects are essential in carbohydrate recognition processes as occurring on the cell surface. Thus many synthetic multivalent glycoconjugates have been developed as important tools for glycobiological research. We are expanding this collection of molecules by the introduction of carbohydrate-scaffolded divalent glycothymine derivatives that can be intramolecularily dimerized by [2 + 2] photocycloaddition. Thus, thymine functions as a control element that allows to restrict the conformational flexibility of the scaffolded sugar ligands and thus to "organize" multivalency. With this work we add a parameter to multivalency studies additional to valency. PMID:26124869

  11. Diagnosing and Treating Intolerance to Carbohydrates in Children

    Directory of Open Access Journals (Sweden)

    Roberto Berni Canani

    2016-03-01

    Full Text Available Intolerance to carbohydrates is relatively common in childhood, but still poorly recognized and managed. Over recent years it has come to the forefront because of progresses in our knowledge on the mechanisms and treatment of these conditions. Children with intolerance to carbohydrates often present with unexplained signs and symptoms. Here, we examine the most up-to-date research on these intolerances, discuss controversies relating to the diagnostic approach, including the role of molecular analysis, and provide new insights into modern management in the pediatric age, including the most recent evidence for correct dietary treatment.

  12. Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet

    DEFF Research Database (Denmark)

    Helge, Jørn Wulff; Watt, Peter W; Richter, Erik A;

    2002-01-01

    -fat (Fat-CHO; 62% fat, 21% carbohydrate) and 6 a high-carbohydrate diet (CHO; 20% fat, 65% carbohydrate) for 7 wk, and thereafter both groups consumed the carbohydrate diet for an eighth week. Training was performed throughout. After 8 wk, during 60 min of exercise (71 +/- 1% pretraining maximal oxygen...... +/- 59 vs. 688 +/- 43 mmol/kg dry wt) in Fat-CHO than in CHO. In conclusion, shift to carbohydrate diet after prolonged adaptation to fat diet and training causes increased resting muscle glycogen levels but impaired leg glucose uptake and similar muscle glycogen breakdown, despite higher resting levels......, compared with when the carbohydrate diet is consumed throughout training....

  13. Prospects of utilization of sugar beet carbohydrates for biological hydrogen production in the EU

    Energy Technology Data Exchange (ETDEWEB)

    Panagiotopoulos, J.A.; Koukios, E.G. [Bioresource Technology Unit, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, GR-15700 (Greece); Bakker, R.R.; De Vrije, T.; Claassen, P.A.M. [Wageningen UR Agrotechnology and Food Innovations, P.O. Box 17, 6700 AA Wageningen (Netherlands); Urbaniec, K. [CERED Centre of Excellence, Warsaw University of Technology, Jachowicza 2/4, 09-402 Plock (Poland)

    2010-12-15

    Hydrogen can be produced through dark anaerobic fermentation using carbohydrate-rich biomass, and through photofermentation using the organic acids produced from dark fermentation. Sugar beet is an ideal energy crop for fermentative production of hydrogen in the EU due to its environmental profile and its potential availability in the area. In this work, various aspects of cultivating sugar beet in the EU for biohydrogen were highlighted, with special focus on The Netherlands and Greece. Moreover, fermentation of sugar beet juice with Caldicellulosiruptor saccharolyticus at sucrose concentration 10 g/l was performed, and was found comparable to the fermentation on pure sucrose except that the hydrogen production was 10% higher on sugar beet juice. A conservative estimate of the annual hydrogen potential in the EU was made (300x10{sup 6} kg hydrogen), considering the utilization of sugar beet pulp in hydrogen production.

  14. Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox

    OpenAIRE

    Mobbs, Charles V.; Mastaitis, Jason; Yen, Kelvin; Schwartz, Joseph; Mohan, Vinuta; Poplawski, Michal; Isoda, Fumiko

    2006-01-01

    High-fat diets produce obesity in part because, per calorie, glucose produces greater post-prandial thermogenesis than lipids, an effect probably mediated by glucose-sensing neurons. A very low carbohydrate/high-fat/high-protein Atkins-type diet produces obesity but is marginally ketogenic in mice. In contrast, high-sucrose/low-fat diets, and very low carbohydrate/high-fat/low-protein (anti-epileptic) ketogenic diets reverse diet-induced obesity independent of caloric intake. We propose that ...

  15. Aspects of functioning and environmental factors in medical work capacity evaluations of persons with chronic widespread pain and low back pain can be represented by a combination of applicable ICF Core Sets

    Directory of Open Access Journals (Sweden)

    Schwegler Urban

    2012-12-01

    Full Text Available Abstract Background Medical work capacity evaluations play a key role in social security schemes because they usually form the basis for eligibility decisions regarding disability benefits. However, the evaluations are often poorly standardized and lack transparency as decisions on work capacity are based on a claimant’s disease rather than on his or her functional capacity. A comprehensive and consistent illustration of a claimant’s lived experience in relation to functioning, applying the International Classification of Functioning, Disability and Health (ICF and the ICF Core Sets (ICF-CS, potentially enhances transparency and standardization of work capacity evaluations. In our study we wanted to establish whether and how the relevant content of work capacity evaluations can be captured by ICF-CS, using disability claimants with chronic widespread pain (CWP and low back pain (LBP as examples. Methods Mixed methods study, involving a qualitative and quantitative content analysis of medical reports. The ICF was used for data coding. The coded categories were ranked according to the percentage of reports in which they were addressed. Relevance thresholds at 25% and 50% were applied. To determine the extent to which the categories above the thresholds are represented by applicable ICF-CS or combinations thereof, measures of the ICF-CS’ degree of coverage (i.e. content validity and efficiency (i.e. practicability were defined. Results Focusing on the 25% threshold and combining the Brief ICF-CS for CWP, LBP and depression for CWP reports, the coverage ratio reached 49% and the efficiency ratio 70%. Combining the Brief ICF-CS for LBP, CWP and obesity for LBP reports led to a coverage of 47% and an efficiency of 78%. Conclusions The relevant content of work capacity evaluations involving CWP and LBP can be represented by a combination of applicable ICF-CS. A suitable standard for documenting such evaluations could consist of the Brief ICF

  16. True information on the late effect of radiation for medical doctors and general public is indispensable for unimpeded development of atomic industry. Lessons learned from psychological aspects of Chernobyl accident

    International Nuclear Information System (INIS)

    The development of atomic industry in Russia and other countries was practically stopped after the Chernobyl accident. The general public opinion was that the potential hazard from atomic energy stations tremendously outbalanced their benefit. Mass media supplied the public with a lot of negative information on the risk of cancer for the exposed persons, making virtually no reference to the dose-effects of cancer induction, and, more frighteningly, of hereditary consequences of the exposure. Importantly, mass media was only a distributor of negative information, which ion fact was generated in scientific and medical circles. Not so many medical doctors performed real epidemiological studies, comparing the incidence of different sickness in the exposed and control groups and thus receiving true information on the health of their patients. On the other hand, many biologists studied the effects of small doses on the cellular level, and a number of statements about the pronounced biological effects of small radiation doses appeared as a result in the literature. For instance, the effects of genetic instability, bystander effect, and the greater death of radioresistant cancer cells after smaller than larger doses can be mentioned. The discovered effects are real, but their direct extrapolation on the state of human health may lead to wrong conclusions. It is also necessary to be cautious in application of non-human data on the hereditary effect of radiation to humans: Such effects are pronounced in Drosophila, well documented in mice but have not practically been registered among the descendants of thousands of persons exposed to doses of several Gy at the Mayak plutonium production/processing factories, or in the settlements downstream Techa river consuming Mayak's sewage waters. It also obligatory for the scientific community to use proper controls while examining the reported cases of the elevated illness among the descendants of the exposed persons to clarify

  17. The factors affecting on estimation of carbohydrate content of meals in carbohydrate counting.

    Science.gov (United States)

    Kawamura, Tomoyuki; Takamura, Chihiro; Hirose, Masakazu; Hashimoto, Tomomi; Higashide, Takashi; Kashihara, Yoneo; Hashimura, Kayako; Shintaku, Haruo

    2015-10-01

    The objective of this study was to identify factors affecting on errors in carbohydrate (CHO) content estimation during CHO counting. Thirty-seven type 1 diabetes patients and 22 of their parents and 28 physicians/dieticians were enrolled in this study. CHO counting was counted in "Carb", with 1 Carb defined as 10 g of CHO. To evaluate the accuracy of CHO counting, 80 real-size photographs of cooked meals were presented to the subjects for Carb estimation. Carbs tended to be overestimated for foods containing relatively small amounts of Carbs. On the other hands, Carbs tended to be underestimated for foods with higher than 6 Carbs. Accurate estimation of the Carbs in food containing a large amount of rice was particularly difficult even in the subjects having the CHO counting experience. The Carb contents of high-calorie foods such as meats, fried foods, and desserts tended to be overestimated. This error was smaller in subjects having the CHO counting experience. In conclusion, misunderstanding of high-calorie dishes containing high amounts of CHO was observed in inexperienced subjects, indicating the efficacy of the current methodology of CHO counting. On the other hand it was difficult even for experienced subjects to assess the amount of seasoned rice, suggesting the need for a new methodology for accurate estimation. PMID:26568656

  18. Terrestrial carbohydrates support freshwater zooplankton during phytoplankton deficiency.

    Science.gov (United States)

    Taipale, Sami J; Galloway, Aaron W E; Aalto, Sanni L; Kahilainen, Kimmo K; Strandberg, Ursula; Kankaala, Paula

    2016-01-01

    Freshwater food webs can be partly supported by terrestrial primary production, often deriving from plant litter of surrounding catchment vegetation. Although consisting mainly of poorly bioavailable lignin, with low protein and lipid content, the carbohydrates from fallen tree leaves and shoreline vegetation may be utilized by aquatic consumers. Here we show that during phytoplankton deficiency, zooplankton (Daphnia magna) can benefit from terrestrial particulate organic matter by using terrestrial-origin carbohydrates for energy and sparing essential fatty acids and amino acids for somatic growth and reproduction. Assimilated terrestrial-origin fatty acids from shoreline reed particles exceeded available diet, indicating that Daphnia may convert a part of their dietary carbohydrates to saturated fatty acids. This conversion was not observed with birch leaf diets, which had lower carbohydrate content. Subsequent analysis of 21 boreal and subarctic lakes showed that diet of herbivorous zooplankton is mainly based on high-quality phytoplankton rich in essential polyunsaturated fatty acids. The proportion of low-quality diets (bacteria and terrestrial particulate organic matter) was zooplankton was not directly related to the concentration of terrestrial organic matter in experiments or lakes, but rather to the low availability of phytoplankton. PMID:27510848

  19. Carbohydrates – Guidelines on Parenteral Nutrition, Chapter 5

    Directory of Open Access Journals (Sweden)

    Working group for developing the guidelines for parenteral nutrition of The German Association for Nutritional Medicine

    2009-11-01

    Full Text Available The main role of carbohydrates in the human body is to provide energy. Carbohydrates should always be infused with PN (parenteral nutrition in combination with amino acids and lipid emulsions to improve nitrogen balance. Glucose should be provided as a standard carbohydrate for PN, whereas the use of xylite is not generally recommended. Fructose solutions should not be used for PN. Approximately 60% of non-protein energy should be supplied as glucose with an intake of 3.0–3.5 g/kg body weight/day (2.1–2.4 mg/kg body weight/min. In patients with a high risk of hyperglycaemia (critically ill, diabetes, sepsis, or steroid therapy an lower initial carbohydrate infusion rate of 1–2 g/kg body weight/day is recommended to achieve normoglycaemia. One should aim at reaching a blood glucose level of 80–110 mg/dL, and at least a glucose level <145 mg/dL should be achieved to reduce morbidity and mortality. Hyperglycaemia may require addition of an insulin infusion or a reduction (2.0–3.0 g/kg body weight/day or even a temporary interruption of glucose infusion. Close monitoring of blood glucose levels is highly important.

  20. Architectures of Multivalent Glycomimetics for Probing Carbohydrate-Lectin Interactions

    Science.gov (United States)

    Lahmann, Martina

    Well-defined multivalent glycoconjugates are valued tools in glycoscience and they are particularly valuable for the investigation of carbohydrate-lectin interactions. In addition to the relatively globularly shaped glycodendrimers many other designs have been realized. This chapter gives an overview on the common different architectures and their chemical synthesis by focussing on the achievements made since 2001.

  1. Protective group strategies in carbohydrate and peptide chemistry

    NARCIS (Netherlands)

    Ali, Asghar

    2010-01-01

    Protecting groups play a key role in the synthesis of complex natural products.This holds especially true for the synthesis of oligosaccharides, of which the monomeric carbohydrate building blocks usually contain up to five different hydroxyl functions. The discrimination of these hydroxyl functions

  2. Simple mucin-type carbohydrate antigens in pleomorphic adenomas

    DEFF Research Database (Denmark)

    Therkildsen, M H; Mandel, U; Christensen, M;

    1993-01-01

    Simple mucin-type carbohydrate structures, T, Tn and sialosyl-Tn, are regarded as general markers of carcinomas in several epithelial tissues as a result of incomplete synthesis with precursor accumulation. The structures have a very limited distribution in normal tissues and secretions, includin...

  3. Carbohydrate maldigestion induces necrotizing enterocolitis in preterm pigs

    Science.gov (United States)

    Necrotizing enterocolitis (NEC) is a major gastrointestinal disorder in preterm infants. Key risk factors for NEC are enteral feeding and microbial colonization. Maldigestion of carbohydrate secondary to immature digestive function has been suspected to cause bacterial overgrowth and NEC. We investi...

  4. Radiation degradation of carbohydrates and their biological activities for plants

    Energy Technology Data Exchange (ETDEWEB)

    Kume, T.; Nagasawa, N.; Matsuhashi, S. [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment] [and others

    2000-03-01

    Radiation effects on carbohydrates such as chitosan, sodium alginate, carrageenan, cellulose, pectin have been investigated to improve the biological activities. These carbohydrates were easily degraded by irradiation and induced various kinds of biological activities such as anti-bacterial activity, promotion of plant growth, suppression of heavy metal stress, phytoalexins induction. Pectic fragments obtained from degraded pectin induced the phytoalexins such as glyceollins in soybean and pisatin in pea. The irradiated chitosan shows the higher elicitor activity for pisatin than that of pectin. For the plant growth promotion, alginate derived from brown marine algae, chitosan and ligno-cellulosic extracts show a strong activity. Kappa and iota carrageenan derived from red marine algae can promote growth of rice and the highest effect was obtained with kappa irradiated at 100 kGy. Some radiation degraded carbohydrates suppressed the damage of heavy metals on plants. The effects of irradiated carbohydrates on transportation of heavy metals have been investigated by PETIS (Positron Emitting Tracer Imaging System) and autoradiography using {sup 48}V and {sup 62}Zn. (author)

  5. Radiation degradation of carbohydrates and their biological activities for plants

    International Nuclear Information System (INIS)

    Radiation effects on carbohydrates such as chitosan, sodium alginate, carrageenan, cellulose, pectin have been investigated to improve the biological activities. These carbohydrates were easily degraded by irradiation and induced various kinds of biological activities such as anti-bacterial activity, promotion of plant growth, suppression of heavy metal stress, phytoalexins induction. Pectic fragments obtained from degraded pectin induced the phytoalexins such as glyceollins in soybean and pisatin in pea. The irradiated chitosan shows the higher elicitor activity for pisatin than that of pectin. For the plant growth promotion, alginate derived from brown marine algae, chitosan and ligno-cellulosic extracts show a strong activity. Kappa and iota carrageenan derived from red marine algae can promote growth of rice and the highest effect was obtained with kappa irradiated at 100 kGy. Some radiation degraded carbohydrates suppressed the damage of heavy metals on plants. The effects of irradiated carbohydrates on transportation of heavy metals have been investigated by PETIS (Positron Emitting Tracer Imaging System) and autoradiography using 48V and 62Zn. (author)

  6. Advancing Analytical Methods for Characterization of Anionic Carbohydrate Biopolymers

    OpenAIRE

    Langeslay, Derek Joseph

    2013-01-01

    The focus of this dissertation is on the development of improved analytical methods for the characterization of anionic carbohydrate biopolymers. Our goal is to extract important information from complex mixtures of heterogeneous polysaccharides by characterizing their substituent oligosaccharides in terms of monosaccharide composition and primary and secondary structure. This work focuses on the application of two major analytical platforms: spectroscopy and chromatography. The development ...

  7. Terrestrial carbohydrates support freshwater zooplankton during phytoplankton deficiency

    Science.gov (United States)

    Taipale, Sami J.; Galloway, Aaron W. E.; Aalto, Sanni L.; Kahilainen, Kimmo K.; Strandberg, Ursula; Kankaala, Paula

    2016-01-01

    Freshwater food webs can be partly supported by terrestrial primary production, often deriving from plant litter of surrounding catchment vegetation. Although consisting mainly of poorly bioavailable lignin, with low protein and lipid content, the carbohydrates from fallen tree leaves and shoreline vegetation may be utilized by aquatic consumers. Here we show that during phytoplankton deficiency, zooplankton (Daphnia magna) can benefit from terrestrial particulate organic matter by using terrestrial-origin carbohydrates for energy and sparing essential fatty acids and amino acids for somatic growth and reproduction. Assimilated terrestrial-origin fatty acids from shoreline reed particles exceeded available diet, indicating that Daphnia may convert a part of their dietary carbohydrates to saturated fatty acids. This conversion was not observed with birch leaf diets, which had lower carbohydrate content. Subsequent analysis of 21 boreal and subarctic lakes showed that diet of herbivorous zooplankton is mainly based on high-quality phytoplankton rich in essential polyunsaturated fatty acids. The proportion of low-quality diets (bacteria and terrestrial particulate organic matter) was directly related to the concentration of terrestrial organic matter in experiments or lakes, but rather to the low availability of phytoplankton. PMID:27510848

  8. DFT solvation studies of carbohydrates: implicit and explicit solvation

    Science.gov (United States)

    Solvents play a role in carbohydrate structure. Therefore, it is important to include solvation effects in calculations to allow a more realistic comparison with experimental data. A possible way to include solvation effects is to use implicit solvation models such as COSMO and PCM. Another avenu...

  9. Sulfurised carbohydrates: An important sedimentary sink for organic carbon?

    NARCIS (Netherlands)

    Sinninghe Damsté, J.S.; Kok, M.D.; Koster, J.; Schouten, S.

    1998-01-01

    In contrast to the general belief that carbohydrate carbon (CCHO) is preferentially degraded and is not extensively preserved in the sedimentary record, it is shown here that CCHO forms a large fraction of the organic matter (OM) of the total organic carbon (TOC)-rich upper Jurassic Kimmeridge Clay

  10. The solvation of carbohydrates in dimethylsulfoxide and water

    International Nuclear Information System (INIS)

    The solvation of sucrose and other carbohydrates in DMSO and water is probed by intermolecular NOE measurements. The NOE effects are interpreted in terms of specific binding of the solvent to certain sites of the molecules. It is shown that DMSO attaches to specific sites of the sucrose molecule, whereas for water such a clear differentiation cannot be proven. (author)

  11. Plant Cell Wall Carbohydrates as Substrates for Azospirillum brasiliense†

    OpenAIRE

    Myers, Mary L.; Hubbell, David H.

    1987-01-01

    Carbohydrate components (simple sugars and polysaccharides) of cell walls of pearl millet (Pennisetum americanum L., cv. Gahi) were studied as potential substrates for the root-associated diazotroph Azospirillum brasiliense Sp. 7. Simple sugars were utilized, but no evidence was obtained to support the suggestion that the polysaccharide components tested might serve as substrates for growth following hydrolysis by the associated azospirilla.

  12. Medical Art Therapy

    Directory of Open Access Journals (Sweden)

    Birgul Aydin

    2012-03-01

    Full Text Available Art therapy is a form of expressive therapy that uses art materials. Art therapy combines traditional psychotherapeutic theories and techniques with an understanding of the psychological aspects of the creative process, especially the affective properties of the different art materials. Medical art therapy has been defined as the clinical application of art expression and imagery with individuals who are physically ill, experiencing physical trauma or undergoing invasive or aggressive medical procedures such as surgery or chemotherapy and is considered as a form of complementary or integrative medicine. Several studies have shown that patients with physical illness benefit from medical art therapy in different aspects. Unlike other therapies, art therapy can take the patients away from their illness for a while by means of creative activities during sessions, can make them forget the illness or lost abilities. Art therapy leads to re-experiencing normality and personal power even with short creative activity sessions. In this article definition, influence and necessity of medical art therapy are briefly reviewed.

  13. Committee on Medical Aspects of Radiation in the Environment (COMARE) 4. report. The incidence of cancer and leukaemia in young people in the vicinity of the Sellafield site, West Cumbria: Further studies and an update of the situation since the publication of the report of the Black Advisory Group in 1984

    International Nuclear Information System (INIS)

    The Fourth Report of the Committee on Medical Aspects of Radiation in the Environment (COMARE) updates the information on the incidence of cancer and leukaemia in young people in the vicinity of the Sellafield site since the publication of the Black Advisory Group report in 1984. Data are reviewed on radiation exposure and the risk of radiation-induced leukaemia and cancer in young people living in Seascale; possible effects of paternal preconception irradiation in cancer; exposure to chemicals used at and discharged from the Sellafield site and the risk to the general population and offspring of site workers; and the infectious aetiology of childhood cancer. The history of the Royal Ordnance Factories sited at Sellafield and Drigg in the 1940s and a historical review of childhood cancer in Seascale is also given. (UK)

  14. Seasonal variation in the chemical composition and carbohydrate signature compounds of biofilm

    Digital Repository Service at National Institute of Oceanography (India)

    DeSouza, F.P.; Garg, A.; Bhosle, N.B.

    :N and organic carbon:chlorophyll a ratios decreased over the period of immersion. Despite the abundance of microalgal biomass, carbohydrate concentration was lower than that observed for proteins. Carbohydrate composition varied during the period of immersion...

  15. Dietary carbohydrate composition can change waste production and biofilter load in recirculating aquaculture systems

    NARCIS (Netherlands)

    Meriac, A.; Eding, E.H.; Schrama, J.W.; Kamstra, A.; Verreth, J.A.J.

    2014-01-01

    This study investigated the effect of dietary carbohydrate composition on the production, recovery and degradability of fecal waste from rainbow trout (Oncorhynchus mykiss) in recirculating aquaculture systems (RAS). Dietary carbohydrate composition was altered by substituting starch with non-starch

  16. Carbohydrate supplementation attenuates decrement in performance in overtrained rats.

    Science.gov (United States)

    Coutinho de Oliveira, Caio Victor; Barbosa, Carlos Vinícius; Massa, Nayara Moreira; Pereira, Reabias de Andrade; Félix, Gustavo da Silva; Aquino, Jailane de Souza; de Oliveira, Edilamar Menezes; Silva, Alexandre Sérgio

    2016-01-01

    Carbohydrate ingestion at the end of a single exercise is recognized as delaying fatigue and accelerating recovery, but whether chronic ingestion can prevent overtraining during periods of intense training has not yet been elucidated. This study aimed to determine whether carbohydrate supplementation minimizes overtraining in Wistar rats. The animals underwent 11 weeks of training (running) on a treadmill, and the last 3 weeks were designed to induce overtraining. One group was supplemented with carbohydrates (EX-CHO) (n = 13), 1 group had no supplementation (EX) (n = 10), and a third group remained inactive (C) (n = 9). Performance tests were given before training (Pr1) and at the 8th (Pr2) and 11th (Pr3) training week. Food intake, body weight, testosterone, cortisol, malondialdehyde, creatine kinase, and activities of the PI3-K, Akt-1, mTOR, and GSK-3 enzymes were measured. In the EX group, there was a significant 32.6% performance decrease at Pr3 when compared with Pr2. In addition, at protocol completion, the EX-CHO group had a greater gastrocnemius weight than did the C group (p = 0.02), which the EX group did not. Training caused anorexia, decreased testosterone (p = 0.001), and increased malondialdehyde (p = 0.009) in both exercise groups compared with the C group, with no influence of carbohydrate supplementation on these variables (p > 0.05). Compared with in the C group, the activity of Akt-1 was higher in the EX-CHO group but not in the EX group (p = 0.013). Carbohydrate supplementation promoted an attenuation in the performance decrement and maintained gastrocnemius muscle mass in animals that had undergone overtraining protocols, which was accompanied by increased activity of the Akt-1 molecular indicator. PMID:26701118

  17. Quality of Vegetable Waste Silages Treated with Various Carbohydrate Sources

    Directory of Open Access Journals (Sweden)

    R. Ridwan

    2013-08-01

    Full Text Available The aim of this research was to evaluate the quality of vegetable waste silages, using rice bran, onggok (cassava flour waste and pollard as carbohydrate sources. Vegetable waste was collected from local traditional market, consisted of corn husk, chinese cabbage and cabbage. Research was held in randomized block design consisted of six treatments with 3 replications. Treatments were (T1 vegetable waste + rice bran, (T2 vegetable waste + rice bran + rice straw, (T3 vegetable waste + onggok, (T4 vegetable waste + onggok + rice straw, (T5 vegetable waste + pollard, (T6 vegetable waste + pollard + rice straw. Lactobacillus plantarum 1A-2 was used as innoculant. The quality of silages was evaluated by measuring pH, temperature, population of lactic acid bacteria and lactic acid production. Nutrient characteristic was determined by proximate and fiber analysis. Results showed that pH of silages were not affected by treatments, but silage treated with rice bran, with or without rice straw addition, had higher temperature compared with others (29 oC or 28.3 oC. The highest population of lactic acid bacteria (1.65 x 109 cfu/g was found in silage using rice straw and onggok (T4, but the highest lactic acid production (0.41% was measured in silage using rice straw and rice bran (T2. In general, the use of rice bran as carbohydrate sources gave the highest lactic acid production followed by pollard and onggok. Different carbohydrate source gave different nutrients characteristic. Although the result was not significantly different, silage with highest protein content was measured in silage with pollard as carbohydrate source, followed with rice bran and onggok. The result showed that all carbohydrate sources used in this experiment can be used as silage ingredient resulting in good vegetable waste silage.

  18. Transcriptional regulation of the carbohydrate utilization network in Thermotoga maritima

    Directory of Open Access Journals (Sweden)

    Dmitry A Rodionov

    2013-08-01

    Full Text Available Hyperthermophilic bacteria from the Thermotogales lineage can produce hydrogen by fermenting a wide range of carbohydrates. Previous experimental studies identified a large fraction of genes committed to carbohydrate degradation and utilization in the model bacterium Thermotoga maritima. Knowledge of these genes enabled comprehensive reconstruction of biochemical pathways comprising the carbohydrate utilization network. However, transcriptional factors (TFs and regulatory mechanisms driving this network remained largely unknown. Here, we used an integrated approach based on comparative analysis of genomic and transcriptomic data for the reconstruction of the carbohydrate utilization regulatory networks in 11 Thermotogales genomes. We identified DNA-binding motifs and regulons for 19 orthologous TFs in the Thermotogales. The inferred regulatory network in T. maritima contains 181 genes encoding TFs, sugar catabolic enzymes and ABC-family transporters. In contrast to many previously described bacteria, a transcriptional regulation strategy of Thermotoga does not employ global regulatory factors. The reconstructed regulatory network in T. maritima was validated by gene expression profiling on a panel of mono- and disaccharides and by in vitro DNA-binding assays. The observed upregulation of genes involved in catabolism of pectin, trehalose, cellobiose, arabinose, rhamnose, xylose, glucose, galactose, and ribose showed a strong correlation with the UxaR, TreR, BglR, CelR, AraR, RhaR, XylR, GluR, GalR, and RbsR regulons. Ultimately, this study elucidated the transcriptional regulatory network and mechanisms controlling expression of carbohydrate utilization genes in T. maritima. In addition to improving the functional annotations of associated transporters and catabolic enzymes, this research provides novel insights into the evolution of regulatory networks in Thermotogales.

  19. Graded sucrose/carbohydrate diets in overtly hypertriglyceridemic diabetic patients.

    Science.gov (United States)

    Jellish, W S; Emanuele, M A; Abraira, C

    1984-12-01

    Overtly hypertriglyceridemic patients with non-insulin-dependent diabetes mellitus were given a control diet containing 120 g of sucrose and 50 percent carbohydrate, and later randomly assigned to receive isocaloric high- (220 g), intermediate- (120 g), or low- (less than 3 g) sucrose/carbohydrate diets for four weeks. The low-sucrose diet group demonstrated a modest but significant decrease in mean fasting serum glucose level in the first week only, although this change was no different from the other two dietary groups and was not sustained. All groups had little change in late postprandial serum glucose levels from control values, and no significant alterations in 24-hour glycosuria. The high-sucrose diet group demonstrated a significant increase in fasting serum triglyceride levels by the second week of the study, whereas the intermediate- and low-sucrose diet groups showed a decrease in mean fasting triglyceride levels. In contrast, the low-sucrose diet group's late postprandial serum triglyceride levels increased by the fourth week, whereas levels fell in the high-sucrose diet group. Mean fasting serum cholesterol concentrations decreased from control values in the high-sucrose diet group. Thus, although very high sucrose and carbohydrate consumption is clearly deleterious to fasting tryglyceride levels in non-insulin-dependent diabetes mellitus with preexisting hypertriglyceridemia, it appears that low dietary sucrose and carbohydrate proportions do not further improve preprandial glycemia and glycosuria and may adversely affect late postprandial serum triglyceride concentration. This study suggests that isocaloric sucrose and carbohydrate restriction below usual daily levels (120 g per day) offers no consistent benefit in glycemia or lipid control in overt type II diabetes. PMID:6391162

  20. Pharmacotherapeutic Aspects of Space Medicine

    Science.gov (United States)

    Putcha, Lakshmi

    2004-01-01

    produced by any drug depend upon rates of absorption, distribution, metabolism, and elimination of the drug; space flight-induced changes in blood flow and the function of the gastrointestinal (GI) tract, liver, or kidneys may alter these processes. Another important aspect of clinical efficacy of medications in space is the stability of pharmaceuticals. As the U.S. space program is moving toward extended Space Shuttle flights and beyond, to space station missions and planetary explorations, understanding how space flight affects organ systems and clinical pharmacology is necessary to optimize pharmacotherapeutics in space and ensure adequate safety and health of crewmembers.

  1. Radiation physics for medical physicists

    CERN Document Server

    Podgorsak, Ervin B

    2006-01-01

    This book summarizes the radiation physics knowledge that professionals working in medical physics need to master for efficient and safe dealings with ionizing radiation. It contains eight chapters, each chapter covering a specific group of subjects related to radiation physics and is intended as a textbook for a course in radiation physics in medical-physics graduate programs. However, the book may also be of interest to the large number of professionals, not only medical physicists, who in their daily occupations deal with various aspects of medical physics and find a need to improve their understanding of radiation physics. The main target audience for this book is graduate students studying for M.Sc. and Ph.D. degrees in medical physics, who have to possess the necessary physics and mathematics background knowledge to be able to follow and master the complete textbook. Medical residents, technology students and biomedical engineering students may find certain sections too challenging or esoteric, yet they...

  2. Carbohydrate derived energy and gross energy absorption in preterm infants fed human milk or formula.

    OpenAIRE

    De Curtis, M; Senterre, J; Rigo, J; Putet, G.

    1986-01-01

    Significant production of breath hydrogen has been shown in premature infants, suggesting limited intestinal capacity for digestion of carbohydrate. To evaluate net absorption of carbohydrate 24 three day balance studies were carried out in seven preterm infants fed pasteurised banked human milk and in 17 preterm infants fed a formula containing 75% lactose and 25% glucose polymers. Because carbohydrate reaching the colon may be converted to organic acids by bacterial flora, carbohydrate net ...

  3. Tetramethylammonium hydroxide thermochemolysis for the analysis of cellulose and free carbohydrates in a peatbog

    OpenAIRE

    Estournel-Pelardy, Céline; Delarue, Frédéric; Grasset, Laurent; Laggoun-Défarge, Fatima; Amblès, André

    2011-01-01

    We have compared TMAH thermochemolysis with the classical method using acid hydrolysis for carbohydrates analysis in a peat core. Even if TMAH thermochemolysis does not analyse hemicellulosic carbohydrates and discriminate each individual carbohydrate sensu stricto, it allows the analysis of a cellulose pool hidden to acid hydrolysis and the specific analysis of free and terminal carbohydrates. Simple direct comparisons of thermochemolysis data with data generated from acid hydrolysis cannot ...

  4. Aspect model unweaving

    OpenAIRE

    Klein, Jacques; Kienzle, J. (ed.); Morin, B.; Jézéquel, J.-M.

    2009-01-01

    Since software systems need to be continuously available, their ability to evolve at runtime is a key issue. The emergence of models@runtime, combined with Aspect-Oriented Modeling techniques, is a promising approach to tame the complexity of adaptive systems. However, with no support for aspect unweaving, these approaches are not agile enough in an adaptive system context. In case of small modifications, the adapted model has to be generated by again weaving all the aspects, even those uncha...

  5. Regulatory aspects of the medical and occupational exposures in the application of the radiosynoviortesis technique; Aspectos regulatorios de las exposiciones medicas y ocupacionales en la aplicacion de la tecnica de radiosinoviortesis

    Energy Technology Data Exchange (ETDEWEB)

    Dumenigo G, C.; Fuente P, A. de la; Quevedo G, J.R.; Lopez F, Y. [Centro Nacional de Seguridad Nuclear, Calle 28 No. 504 e/5 y 7 Ave. Miramar, Playa, Ciudad de la Habana (Cuba)]. e-mail: cruz@orasen.co.cu

    2006-07-01

    The Radiosynoviortesis is a to therapeutic proceed that consists in the injection of a radiopharmaceutical beta transmitter in the synovial cavity of the articulations affected by arthropaties. With it is achieved to cause the fibrosis and remodeling of the synovial membrane obtaining a remarkable improvement in the patients that it includes the disappearance of the pain and the increase of the flexibility of the treated articulation. The technique began to be carried out from 1952 in Europe when it was injected Au{sup 196} in patients affected by rheumatoid arthropaties and starting from then it has gone winning followers in Canada, United States, Australia and some countries of Latin America. Their results are satisfactory and they have been endorsed by the practice. In Cuba it was carried out at November 16, 2002 a clinical essay with the use of this technique, the same one was Graduate by the National Center of Nuclear Safety, in their condition of Regulatory Authority, for it the National Institute of Hematology and Immunology presented the technical documentation that bases its safety. However for the generalization of this technique and their inclusion in the Nuclear Medicine services already existent, the Regulatory Authority has indicated a group of requirements that should be kept in mind in a such way that the application of the Radiosynoviortesis fulfills the Regulation of those 'Basic Norms of Radiological Safety' effective in our country. The present work exposes the particularities and challenges that the Radiosynoviortesis outlines from the point of view of the Radiological Protection, as well as the technical aspects that should be kept in mind for its Licensing, in such way that the is guaranteed safety of the same one in the relative thing to the radiological protection of the patients, those workers and the one publishes. The work reaffirms the feasibility of this to therapeutic proceed from the point of view of the radiological

  6. Medical marijuana.

    OpenAIRE

    Marmor, J B

    1998-01-01

    Although many clinical studies suggest the medical utility of marijuana for some conditions, the scientific evidence is weak. Many patients in California are self-medicating with marijuana, and physicians need data to assess the risks and benefits. The only reasonable solution to this problem is to encourage research on the medical effects of marijuana. The current regulatory system should be modified to remove barriers to clinical research with marijuana. The NIH panel has identified several...

  7. Structural analysis of the carbohydrate chains of glycoproteins by 500-MHz 1H-NMR spectroscopy

    International Nuclear Information System (INIS)

    This thesis deals with the structural analysis by 500-MHz 1H-NMR spectroscopy of carbohydrate chains obtained from glycoproteins. In the chapters 1 to 6 the structural analysis of N-glycosidically linked carbohydrate chains is described. The chapters 7 to 10 describe the structural analysis of O-glycosidically linked carbohydrate chains. 381 refs.; 44 figs.; 24 tabs.; 7 schemes

  8. DMPD: Sweet preferences of MGL: carbohydrate specificity and function. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18249034 Sweet preferences of MGL: carbohydrate specificity and function. van Vliet....csml) Show Sweet preferences of MGL: carbohydrate specificity and function. PubmedID 18249034 Title Sweet p...references of MGL: carbohydrate specificity and function. Authors van Vliet SJ, S

  9. Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration

    Science.gov (United States)

    Little is known about the association between dietary carbohydrates and cataract in nondiabetic persons. The aim was to test whether recent dietary carbohydrate intakes or glycemic index (GI; a measure of carbohydrate intake quality) was associated with the presence of cortical or nuclear opacities....

  10. Medical Tourism Development in Croatia

    OpenAIRE

    Oliver Kesar Katarina Rimac

    2011-01-01

    This article is primarily focused on medical tourism, one of the most interesting aspects of health tourism development, originally conceived as a marketing tool for attracting international demand for health care services. The purpose of this article is to summarize the rationale of promoting medical tourism development in developing countries like Croatia, and to assess the opportunities and constraints of such product development in present socio-economic conditions. The theoretical backgr...

  11. Comparison of docking methods for carbohydrate binding in calcium-dependent lectins and prediction of the carbohydrate binding mode to sea cucumber lectin CEL-III

    OpenAIRE

    Nurisso, Alessandra; Kozmon, Stanislav; Imberty, Anne

    2008-01-01

    Abstract Lectins display a variety of strategies for specific recognition of carbohydrates. In several lectin families from different origin, one or two calcium ions are involved in the carbohydrate binding site with direct coordination of the sugar hydroxyl groups. Our work implied a molecular docking study involving a set of bacterial and animal calcium-dependant lectins in order to compare the ability of three docking programs to reproduce key carbohydrate-metal interactions. Fl...

  12. Selective preservation of carbohydrates in volcanic ash soils

    Science.gov (United States)

    Kaal, J.; Buurman, P.; Nierop, K. G. J.; Piccolo, A.

    2009-04-01

    Volcanic soils (Andosols) are formed in volcanic ash and depending on environmental and climatic factors they develop to two main forms, either allophanic Andosols (dominated by amorphous minerals) or non-allophanic Andosols (dominated by Al/Fe organic matter complexes). Andosols contain the largest amounts of organic carbon of all mineral soil orders. In recent studies using analytical pyrolysis techniques on the soil organic matter (SOM) of allophanic soils from the Azores Islands (Portugal) there was no indication of preservation of plant-derived organic matter by allophane or Al3+, but the presence of large amounts of (microbial) polysaccharides and chitin suggested that secondary organic matter products were stabilized. In the present study we used 13C NMR to further explore the organic matter of the Andosols of the Azores, and applied a molecular mixing model (MMM; ascribing characteristic resonances to the main biocomponent classes carbohydrate, protein, lipid, lignin and char) to the quantified NMR spectra to allow for a quantitative comparison with pyrolysis-GC/MS. The dominance of O-alkyl and di-O-alkyl C in the NMR spectra and carbohydrate contribution to the predictions made by the MMM (50 ± 8%) confirms that the majority of the SOM can still be recognised as carbohydrate. The accumulation of secondary/microbial carbohydrates (and, to a lesser extent, secondary proteinaceous matter and chitins) is thus a key characteristic of these Andosols. NMR-MMM and pyrolysis-GC/MS were in rough agreement. However, NMR does not recognise chitin (N-containing carbohydrate-like material) and chitin-associated protein, nor can it be used to estimate the degree of degradation of the carbohydrates. Therefore, NMR (as applied here) has a very limited capacity for characterisation of the SOM particularly in the Andosols studied. On the other hand, large peaks from carboxylic and amidic functional groups detected by NMR were not observed by pyrolysis-GC/MS. It is therefore

  13. Medical Complex

    OpenAIRE

    Kumaraswamy, Mohan

    2002-01-01

    One element of the CIVCAL project Web-based resources containing images, tables, texts and associated data on the construction of the Medical Complex. This project covers the construction of a new Hong Kong University Medical Complex on Sassoon Road, Pokfulam. The complex will comprise two buildings, one will house laboratories and a car park, while the other will contain lecture halls

  14. Method for improving separation of carbohydrates from wood pulping and wood or biomass hydrolysis liquors

    Science.gov (United States)

    Griffith, William Louis; Compere, Alicia Lucille; Leitten, Jr., Carl Frederick

    2010-04-20

    A method for separating carbohydrates from pulping liquors includes the steps of providing a wood pulping or wood or biomass hydrolysis pulping liquor having lignin therein, and mixing the liquor with an acid or a gas which forms an acid upon contact with water to initiate precipitation of carbohydrate to begin formation of a precipitate. During precipitation, at least one long chain carboxylated carbohydrate and at least one cationic polymer, such as a polyamine or polyimine are added, wherein the precipitate aggregates into larger precipitate structures. Carbohydrate gel precipitates are then selectively removed from the larger precipitate structures. The method process yields both a carbohydrate precipitate and a high purity lignin.

  15. Natural Cytotoxicity Receptors: Pattern Recognition and Involvement of Carbohydrates

    Directory of Open Access Journals (Sweden)

    Angel Porgador

    2005-01-01

    Full Text Available Natural cytotoxicity receptors (NCRs, expressed by natural killer (NK cells, trigger NK lysis of tumor and virus-infected cells on interaction with cell-surface ligands of these target cells. We have determined that viral hemagglutinins expressed on the surface of virus-infected cells are involved in the recognition by the NCRs, NKp44 and NKp46. Recognition of tumor cells by the NCRs NKp30 and NKp46 involves heparan sulfate epitopes expressed on the tumor cell membrane. Our studies provide new evidence for the identity of the ligands for NCRs and indicate that a broader definition should be applied to pathological patterns recognized by innate immune receptors. Since nonmicrobial endogenous carbohydrate structures contribute significantly to this recognition, there is an imperative need to develop appropriate tools for the facile sequencing of carbohydrate moieties.

  16. Vaccines based on the cell surface carbohydrates of pathogenic bacteria

    Directory of Open Access Journals (Sweden)

    Jones Christopher

    2005-01-01

    Full Text Available Glycoconjugate vaccines, in which a cell surface carbohydrate from a micro-organism is covalently attached to an appropriate carrier protein are proving to be the most effective means to generate protective immune responses to prevent a wide range of diseases. The technology appears to be generic and applicable to a wide range of pathogens, as long as antibodies against surface carbohydrates help protect against infection. Three such vaccines, against Haemophilus influenzae type b, Neisseria meningitidis Group C and seven serotypes of Streptococcus pneumoniae, have already been licensed and many others are in development. This article discusses the rationale for the development and use of glycoconjugate vaccines, the mechanisms by which they elicit T cell-dependent immune responses and the implications of this for vaccine development, the role of physicochemical methods in the characterisation and quality control of these vaccines, and the novel products which are under development.

  17. Identification and estimation ot carbohydrates using radioisotopic methods

    International Nuclear Information System (INIS)

    Isotope-dilution methods have been developed to identify and estimate the small amount of products formed when carbohydrates are irradiated in aqueous solution with Co60 gamma-radiation. Conventional analytical methods proved inadequate. After irradiation of C14-sugar solutions, the autoradiographs prepared after paper chromatography indicated extensive degradation. Using a reverse isotope-dilution procedure involving the addition of known carriers, and conversion of the fragments into crystalline derivatives, various constituents were quantitatively determined. It is possible to distinguish between d- and Z-isomers, and estimate each isomer independently. The method is applicable to other analytical problems in carbohydrate chemistry. A new method for scanning and recording the radioactivity along paper-chromatogram strips, which involves an inexpensive modification to conventional counting equipment, is described. (author)

  18. Carbohydrate maldigestion induces necrotizing enterocolitis in preterm pigs

    DEFF Research Database (Denmark)

    Thymann, Thomas; Møller, Hanne; Stoll, Barbara;

    2009-01-01

    aldohexose absorption (4% vs. 42%) and greater intestinal recovery of undigested carbohydrate (68% vs. 27%) in pigs acutely perfused with the maltodextrin-based formula than those perfused with the lactose-based formula. The higher digestibility of the lactose than the maltodextrin in the formulas can be...... 1, 2009; doi: 10.1152/ajpgi.00261.2009. Necrotizing enterocolitis (NEC) remains the most severe gastrointestinal disorder in preterm infants. It is associated with the initiation of enteral nutrition and may be related to immature carbohydrate digestive capacity. We tested the hypothesis that a...... concentrations of short-chain fatty acids were observed in the maltodextrin group. In a second study, we quantified net portal absorption of aldohexoses (glucose and galactose) during acute jejunal infusion of a maltodextrin-or a lactose-based formula (n = 8) into preterm pigs. We found lower net portal...

  19. Cell surface carbohydrate changes during embryonic and fetal skin development

    DEFF Research Database (Denmark)

    Dabelsteen, Erik; Holbrook, K; Clausen, H;

    1986-01-01

    Monoclonal antibodies to four type 2 chain carbohydrate antigens were used for immunohistochemical studies of embryonic and fetal skin. The antibodies detected N-acetyllactosamine and 3 fucosyl substitutes of this, blood group antigen H, Lex, and Ley. Periderm consistently stained for N-acetyllac......Monoclonal antibodies to four type 2 chain carbohydrate antigens were used for immunohistochemical studies of embryonic and fetal skin. The antibodies detected N-acetyllactosamine and 3 fucosyl substitutes of this, blood group antigen H, Lex, and Ley. Periderm consistently stained for N...... maximally expressed at the early stages of development, but may later be modified either by sialylation or fucosylation into blood group H or Lex, or by Ley substances, respectively. The orderly and well-defined changes observed during skin differentiation are in agreement with other studies, which have...

  20. Normal Roles for Dietary Fructose in Carbohydrate Metabolism

    Directory of Open Access Journals (Sweden)

    Maren R. Laughlin

    2014-08-01

    Full Text Available Although there are many well-documented metabolic effects linked to the fructose component of a very high sugar diet, a healthy diet is also likely to contain appreciable fructose, even if confined to that found in fruits and vegetables. These normal levels of fructose are metabolized in specialized pathways that synergize with glucose at several metabolic steps. Glucose potentiates fructose absorption from the gut, while fructose catalyzes glucose uptake and storage in the liver. Fructose accelerates carbohydrate oxidation after a meal. In addition, emerging evidence suggests that fructose may also play a role in the secretion of insulin and GLP-1, and in the maturation of preadipocytes to increase fat storage capacity. Therefore, fructose undergoing its normal metabolism has the interesting property of potentiating the disposal of a dietary carbohydrate load through several routes.

  1. Impeded Carbohydrate Metabolism in Rice Plants under Submergence Stress

    Institute of Scientific and Technical Information of China (English)

    Malay Kumar ADAK; Nirmalya GHOSH; Dilip Kumar DASGUPTA; Sudha GUPTA

    2011-01-01

    The detrimental effects of submergence on physiological performances of some rice varieties with special references to carbohydrate metabolisms and their allied enzymes during post-flowering stages have been documented and clarified in the present investigation.It was found that photosynthetic rate and concomitant translocation of sugars into the panicles were both related to the yield.The detrimental effects of the complete submergence were recorded in generation of sucrose,starch,sucrose phosphate synthase and phosphorylase activity in the developing panicles of the plants as compared to those under normal or control (i.e.non-submerged) condition.The accumulation of starch was significantly lower in plants under submergence and that was correlated with ADP-glucose pyrophosphorylase activity.Photosynthetic rate was most affected under submergence in varying days of post-flowering and was also related to the down regulation of Ribulose bisphosphate carboxylase activity.However,under normal or control condition,there recorded a steady maintenance of photosynthetic rate at the post-flowering stages and significantly higher values of Ribulose bisphosphate carboxylase activity.Still,photosynthetic rate of the plants under both control and submerged conditions had hardly any significant correlation with sugar accumulation and other enzymes of carbohydrate metabolism like invertase with grain yield.Finally,plants under submergence suffered significant loss of yield by poor grain filling which was related to impeded carbohydrate metabolism in the tissues.It is evident that loss of yield under submergence is attributed both by lower sink size or sink capacity (number of panicles,in this case) as well as subdued carbohydrate metabolism in plants and its subsequent partitioning into the grains.

  2. Carbohydrate availability of arroz caldo with lambda-carrageenan.

    Science.gov (United States)

    Dumelod, B D; Ramirez, R P; Tiangson, C L; Barrios, E B; Panlasigui, L N

    1999-07-01

    Total available carbohydrate (sugars and starches) and total dietary fiber (soluble and insoluble) make up the total carbohydrate content of a food. Soluble fiber decreases the availability of glucose by delaying its absorption in the proximal small intestine, thus reducing the postprandial glucose levels (Jenkins et al., 1978; Schneeman, 1987a). Carrageenan, a seaweed extract, is a good source of soluble fiber (Montaño et al., 1985). This study aimed to determine the effect of carrageenan incorporation into arroz caldo on carbohydrate availability by monitoring the postprandial blood glucose levels of normal subjects. Control and experimental arroz caldo samples were prepared and subjected to proximate analysis and feeding studies. The total dietary fiber (TDF) content of the experimental (2.03%) was about thrice that of the control (0.68%). Using randomized crossover design, preweighed 55 g available carbohydrate serving portions of control and experimental arroz caldo samples, with 3.45 and 14.84 g TDF, respectively, were fed to ten fasting normal subjects then their postprandial blood glucose levels were determined at 15, 30, 45, 60 and 90 min intervals. Results of the short-term in vivo study showed that the mean postprandial glycaemic responses of subjects after consuming the experimental sample were significantly lower than the levels after consuming the control at 15, 45, and 90 min (P arroz caldo than control (147.29 +/- 53.34). The hypoglycaemic effect of carrageenan may prove useful in the prevention and management of metabolic conditions such as diabetes. PMID:10719574

  3. GLYCAM06: A Generalizable Biomolecular Force Field. Carbohydrates

    OpenAIRE

    Kirschner, Karl N.; Yongye, Austin B.; Tschampel, Sarah M.; GONZÁLEZ-OUTEIRIÑO, JORGE; DANIELS, CHARLISA R.; Foley, B. Lachele; Woods, Robert J.

    2008-01-01

    A new derivation of the GLYCAM06 force field, which removes its previous specificity for carbohydrates, and its dependency on the AMBER force field and parameters, is presented. All pertinent force field terms have been explicitly specified and so no default or generic parameters are employed. The new GLYCAM is no longer limited to any particular class of biomolecules, but is extendible to all molecular classes in the spirit of a small-molecule force field. The torsion terms in the present wo...

  4. Protective group strategies in carbohydrate and peptide chemistry

    OpenAIRE

    Ali, Asghar

    2010-01-01

    Protecting groups play a key role in the synthesis of complex natural products.This holds especially true for the synthesis of oligosaccharides, of which the monomeric carbohydrate building blocks usually contain up to five different hydroxyl functions. The discrimination of these hydroxyl functions requires a careful protecting group strategy and typically involves multistep protocols.This thesis describes the prepartion, installation, their use in the synthesis of stereoselective glycosidic...

  5. Structure, dynamics and reactivity of carbohydrates : NMR spectroscopic studies

    OpenAIRE

    Rönnols, Jerk

    2013-01-01

    The main focus of this thesis is on the ring conformations of carbohydrate molecules; how the conformational equilibria and the rates of the associated interconversions are affected by the molecular constitution and their surroundings. The conformational equilibria of a group of amine linked pseudodisaccharides, designed as potential glycosidase inhibitors, comprising α-D-altrosides are described in Chapter 3. The OS2 conformation was largely populated, and the ring conformation was found to ...

  6. Structural Characterization of Carbohydrates by Fourier Transform Tandem Mass Spectrometry

    OpenAIRE

    Zhou, Wen; Håkansson, Kristina

    2011-01-01

    Fourier transform tandem mass spectrometry (MS/MS) provides high mass accuracy, high sensitivity, and analytical versatility and has therefore emerged as an indispensable tool for structural elucidation of biomolecules. Glycosylation is one of the most common posttranslational modifications, occurring in ~50% of proteins. However, due to the structural diversity of carbohydrates, arising from non-template driven biosynthesis, achievement of detailed structural insight is highly challenging. T...

  7. Carbohydrate recognition by the antiviral lectin cyanovirin-N

    OpenAIRE

    Fujimoto, Yukiji K.; Green, David F.

    2012-01-01

    Cyanovirin-N is a cyanobacterial lectin with potent antiviral activity, and has been the focus of extensive pre-clinical investigation as a potential prophylactic for the prevention of the sexual transmission of the human immunodeficiency virus (HIV). Here we present a detailed analysis of carbohydrate recognition by this important protein, using a combination of computational methods, including extensive molecular dynamics simulations and Molecular-Mechanics/ Poisson–Boltzmann/Surface-Area (...

  8. Carbohydrate malabsorption in patients with non-specific abdominal complaints

    OpenAIRE

    Born, Peter

    2007-01-01

    Non-specific abdominal complaints are a considerable problem worldwide. Many patients are affected and many differential diagnoses have to be considered. Among these, carbohydrate malabsorption seems to play an important role. However, so far, only incomplete absorption of lactose is broadly accepted, while the malabsorption of fructose and sorbitol is still underestimated, although in many parts of the world it is much more frequent. Despite the success of dietary interventions in many patie...

  9. Unclear Abdominal Discomfort: Pivotal Role of Carbohydrate Malabsorption

    OpenAIRE

    Goebel-Stengel, Miriam; Stengel, Andreas; Schmidtmann, Marco; van der Voort, Ivo; Kobelt, Peter; Mönnikes, Hubert

    2014-01-01

    Background/Aims Carbohydrate malabsorption is frequent in patients with functional gastrointestinal disorders and in healthy volunteers and can cause gastrointestinal symptoms mimicking irritable bowel syndrome (IBS). The aim of this study was to investigate the prevalence of symptomatic lactose and fructose malabsorption in a large population of patients with IBS-like symptoms based on Rome II criteria. Methods Patients with unclear abdominal discomfort (n = 2,390) underwent lactose (50 g) a...

  10. A randomized trial of preoperative oral carbohydrates in abdominal surgery

    OpenAIRE

    Sada, Fatos; Krasniqi, Avdyl; Hamza, Astrit; Gecaj-Gashi, Agreta; Bicaj, Besnik; Kavaja, Floren

    2014-01-01

    Background Carbohydrate-rich liquid drinks (CRLDs) have been recommended to attenuate insulin resistance by shortening the preoperative fasting interval. The aim of our study the effect of preoperative oral administration of CRLDs on the well-being and clinical status of patients. Methods A randomized, double blind, prospective study of patients undergoing open colorectal operations (CR) and open cholecyctectomy (CH) was conducted. Patients were divided into three groups: study, placebo, and ...

  11. Cloning and expression of carbohydrate binding module in Pichia pastoris

    OpenAIRE

    Moreira, Susana Margarida Gomes; Domingues, Lucília; Gama, F. M.; Casal, Margarida

    2005-01-01

    The main goal of this work is the production of recombinant biologically active peptides fused with a Carbohydrate Binding Module (CBM). Aiming at the optimization of large scale expression, CBM peptide production was done by cloning CBM coding sequence in two different systems of Pichia pastoris: pGAPZαC which has a constitutive promoter and pPICZαC which has an inductive promoter. The integration of the CBM coding sequence in the yeast genome was confirmed by slot-blot for...

  12. Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short

    Czech Academy of Sciences Publication Activity Database

    Bojarová, Pavla; Křen, Vladimír

    2011-01-01

    Roč. 65, 1-2 (2011), 64-70. ISSN 0009-4293 R&D Projects: GA ČR GP203/09/P024; GA MŠk(CZ) LC06010; GA MŠk OC09045 Institutional research plan: CEZ:AV0Z50200510 Keywords : Carbohydrate * Enzymatic synthesis * Glycosidase Subject RIV: CC - Organic Chemistry Impact factor: 1.212, year: 2011

  13. Performance of finishing steers fed different sources of carbohydrates

    Directory of Open Access Journals (Sweden)

    Leandro da Silva Freitas

    2013-05-01

    Full Text Available The objective of this study was to evaluate the effect of carbohydrate sources (corn, soybean hulls or wheat bran in the diet on performance of feedlot steers in the finishing phase. Twenty-four Charolais × Nellore crossbred steers, aged 22 months and initial weight of 335.0±10.9 kg were used in the experiment. Diets contained 40% sorghum silage and 60% concentrate. The intakes of dry matter (DM; 10.68, 10.16 and 10.34 kg/day and crude protein (1.66, 1.70 and 1.72 kg/day were not affected by diets with corn, soybean hulls or wheat bran, respectively. The intakes of neutral and acid detergent fiber were higher for soybean hulls, but the diet containing corn provided higher intake of non-fibrous carbohydrates, total digestible nutrients and digestible energy. Weight gain was higher and better feed conversion for animals fed corn (1.57 kg/day, 6.85 kg DM/kg gain or soybean hulls (1.58 kg/day and 6.61 kg DM/kg gain compared with steers receiving wheat bran (1.29 kg/day and 8.14 kg DM/kg gain in the diet. There was no significant effect of carbohydrate sources on the final body score (3.78 points, energy conversion (28.25 Mcal digestible energy/kg gain, hot carcass yield (57.63 kg/100 kg BW and fat thickness (3.1 mm. From an economic point of view, soybean hulls can be an alternative source of carbohydrate to corn in diets of finishing steers with 60% concentrate.

  14. Effects of disturbance regime on carbohydrate reserves in meadow plants

    Czech Academy of Sciences Publication Activity Database

    Janeček, Štěpán; Bartušková, Alena; Bartoš, Michael; Altman, Jan; de Bello, Francesco; Doležal, Jiří; Latzel, Vít; Lanta, V.; Lepš, J.; Klimešová, Jitka

    2015-01-01

    Roč. 7, plv123 (2015), s. 1-16. ISSN 2041-2851 R&D Projects: GA ČR GA526/09/0963; GA ČR GAP505/12/1296; GA ČR GB14-36079G Institutional support: RVO:67985939 Keywords : Carbohydrates * management * meadow Subject RIV: EH - Ecology, Behaviour Impact factor: 2.273, year: 2014

  15. Quality of Vegetable Waste Silages Treated with Various Carbohydrate Sources

    OpenAIRE

    R. Ridwan; Y. Widyastuti; W.D. Astuti; E. Yetti

    2013-01-01

    The aim of this research was to evaluate the quality of vegetable waste silages, using rice bran, onggok (cassava flour waste) and pollard as carbohydrate sources. Vegetable waste was collected from local traditional market, consisted of corn husk, chinese cabbage and cabbage. Research was held in randomized block design consisted of six treatments with 3 replications. Treatments were (T1) vegetable waste + rice bran, (T2) vegetable waste + rice bran + rice straw, (T3) vegetable waste + onggo...

  16. Compositional Analysis of Carbohydrates of a Family of Legumes

    OpenAIRE

    Raghothama, Arvind; Hamaker, Bruce

    2013-01-01

    Legumes, most commonly identified as beans or lentils, provide a good source of both protein and carbohydrates. Many legumes contain the polysaccharide arabinogalactans, classified as dietary fiber and have unique functional properties in foods. However, these, and other plant polysaccharides have not been well characterized. A preliminary collaborative study between Florida State University and the Whistler Center at Purdue indicated that isolated legume arabinogalactans appear to have high ...

  17. Carbohydrate Provision in the Era of Tight Glucose Control

    OpenAIRE

    Miller, Keith R.; Lawson, Christy M; Smith, Vance L.; HARBRECHT, BRIAN G

    2011-01-01

    Glycemic control in the critically ill patient has remained a controversial issue over the last decade. Several large trials, with widely varying results, have generated significant interest in defining the optimal target for blood-glucose control necessary for improving care while minimizing morbidity. Nutritional support has evolved into an additional area of critical care where appropriate practices have been associated with improved patient outcomes. Carbohydrate provision can impact bloo...

  18. Comparison of Carbohydrate Compositions of Total Apolipoproteins in Lipoproteins

    OpenAIRE

    Güldür, Tayfun; OZAN, Sema; İLERİ, Tülay

    1998-01-01

    Terminal carbohydrate moieties of apolipoproteins of lipoproteins in human and goat serum were ascertained and compared. Apolipoproteins of b+pre-b (apolipoprotein B containing lipoproteins) and a lipoproteins separated by phosphotungstic acid/MgCl2 precipitation method were applied to SDS-PAGE and blotted onto nitrocellulose membrane. Digoxigenin labelled lectins, each of which recognizes a specific sugar sequence, were incubated with apolipoproteins immobilized on a western blot membrane to...

  19. Genetic Aspects of Nephrotic Syndrome

    DEFF Research Database (Denmark)

    Joshi, Shivani

    a modifier. Nonetheless, such a combination might have variable penetrance and hence different age of onset. Thus, genetic testing in SRNS is important as it might give clues to the cause and save exposure of immunosuppressive medications in future patients with same genotype. Families comprising...... steroid dependence or become frequent relapsers. Repeated courses of corticosteroid treatment often cause significant associated morbidity. Familial occurrence of SSNS is rare and suggests a potential genetic origin. However, very little data on molecular genetics of familial SSNS is available in...... literature and no causal genes have yet been identified. Genetic aspects of NS bear important implications in therapeutic decisions and genetic counselling in SRNS patients and family members. During the present Ph.D. project we have studied the influence of genetic factors in patients with SRNS and familial...

  20. A mini review of dolphin carbohydrate metabolism and suggestions for future research using exhaled air

    Directory of Open Access Journals (Sweden)

    Sam eRidgway

    2013-12-01

    Full Text Available In the 1960s, I explored some aspects of carbohydrate metabolism in healthy bottlenose dolphins (Tursiops truncatus. Their physiological picture resembled what had been described for hyperthyroid diabetics. Dolphins have elevated thyroid hormone turnover, and fasting dolphins maintain a relatively high level of plasma glucose. After dolphins ingest glucose, plasma levels remain high for many hours. Interestingly, plasma glucose must exceed 300 mg/dL (about twice as high as the human threshold before glucose appears in urine. Due to their diabetes-like states, trainability, and unique natural respiratory anatomy and physiology, dolphins may offer useful clues to metabolites in the breath that may be used to non-invasively monitor diabetes in humans. Dolphins take very rapid and deep breaths that are four or five times as deep as humans and other terrestrial mammals, making them ideal for physiological assessment using non-invasive exhaled air. Avenues for successfully identifying breath-based markers for metabolic disease and physiology in dolphins can be done with both modern technology and the evolutionarily advantageous canine nose. This review summarizes aspects of dolphin metabolism previously learned and offers new directions for diabetes research that may benefit both dolphin and human health.

  1. Restricting carbohydrates to fight head and neck cancer—is this realistic?

    International Nuclear Information System (INIS)

    Head and neck cancers (HNCs) are aggressive tumors that typically demonstrate a high glycolytic rate, which results in resistance to cytotoxic therapy and poor prognosis. Due to their location these tumors specifically impair food intake and quality of life, so that prevention of weight loss through nutrition support becomes an important treatment goal. Dietary restriction of carbohydrates (CHOs) and their replacement with fat, mostly in form of a ketogenic diet (KD), have been suggested to accommodate for both the altered tumor cell metabolism and cancer-associated weight loss. In this review, I present three specific rationales for CHO restriction and nutritional ketosis as supportive treatment options for the HNC patient. These are (1) targeting the origin and specific aspects of tumor glycolysis; (2) protecting normal tissue from but sensitizing tumor tissue to radiation- and chemotherapy induced cell kill; (3) supporting body and muscle mass maintenance. While most of these benefits of CHO restriction apply to cancer in general, specific aspects of implementation are discussed in relation to HNC patients. While CHO restriction seems feasible in HNC patients the available evidence indicates that its role may extend beyond fighting malnutrition to fighting HNC itself

  2. Restricting carbohydrates to ifght head and neck cancer-is this realistic?

    Institute of Scientific and Technical Information of China (English)

    Rainer JKlement

    2014-01-01

    Head and neck cancers (HNCs) are aggressive tumors that typically demonstrate a high glycolytic rate, which results in resistance to cytotoxic therapy and poor prognosis. Due to their location these tumors speciifcally impair food intake and quality of life, so that prevention of weight loss through nutrition support becomes an important treatment goal. Dietary restriction of carbohydrates (CHOs) and their replacement with fat, mostly in form of a ketogenic diet (KD), have been suggested to accommodate for both the altered tumor cell metabolism and cancer-associated weight loss. In this review, I present three specific rationales for CHO restriction and nutritional ketosis as supportive treatment options for the HNC patient. These are (1) targeting the origin and specific aspects of tumor glycolysis; (2) protecting normal tissue from but sensitizing tumor tissue to radiation- and chemotherapy induced cell kill; (3) supporting body and muscle mass maintenance. While most of these beneifts of CHO restriction apply to cancer in general, speciifc aspects of implementation are discussed in relation to HNC patients. While CHO restriction seems feasible in HNC patients the available evidence indicates that its role may extend beyond ifghting malnutrition to ifghting HNC itself.

  3. Reuteran and levan as carbohydrate sinks in transgenic sugarcane.

    Science.gov (United States)

    Bauer, Rolene; Basson, Carin E; Bekker, Jan; Eduardo, Iban; Rohwer, Johann M; Uys, Lafras; van Wyk, Johannes H; Kossmann, Jens

    2012-12-01

    The present study reports the effect of high molecular weight bacterial fructan (levan) and glucan (reuteran) on growth and carbohydrate partitioning in transgenic sugarcane plants. These biopolymers are products of bacterial glycosyltransferases, enzymes that catalyze the polymerization of glucose or fructose residues from sucrose. Constructs, targeted to different subcellular compartments (cell wall and cytosol) and driven by the Cauliflower mosaic virus-35S: maize-ubiquitin promoter, were introduced into sugarcane by biolistic transformation. Polysaccharide accumulation severely affected growth of callus suspension cultures. Regeneration of embryonic callus tissue into plants proved problematic for cell wall-targeted lines. When targeted to the cytosol, only plants with relative low levels of biopolymer accumulation survived. In internodal stalk tissue that accumulate reuteran (max 0.03 mg/g FW), sucrose content (ca 60 mg/g FW) was not affected, while starch content (<0.4 mg/g FW) was increased up to four times. Total carbohydrate content was not significantly altered. On the other hand, starch and sucrose levels were significantly reduced in plants accumulating levan (max 0.01 mg/g FW). Heterologous expression resulted in a reduction in total carbohydrate assimilation rather than a simple diversion by competition for substrate. PMID:22903192

  4. Lanthanide-IMAC enrichment of carbohydrates and polyols.

    Science.gov (United States)

    Schemeth, Dieter; Rainer, Matthias; Messner, Christoph B; Rode, Bernd M; Bonn, Günther K

    2014-03-01

    In this study a new type of immobilized metal ion affinity chromatography resin for the enrichment of carbohydrates and polyols was synthesized by radical polymerization reaction of vinyl phosphonic acid and 1,4-butandiole dimethacrylate using azo-bis-isobutyronitrile as radical initiator. Interaction between the chelated trivalent lanthanide ions and negatively charged hydroxyl groups of carbohydrates and polyols was observed by applying high pH values. The new method was evaluated by single standard solutions, mixtures of standards, honey and a more complex extract of Cynara scolymus. The washing step was accomplished by acetonitrile in excess volumes. Elution of enriched carbohydrates was successfully performed with deionized water. The subsequent analysis was carried out with matrix-free laser desorption/ionization-time of flight mass spectrometry involving a TiO2 -coated steel target, especially suitable for the measurement of low-molecular-weight substances. Quantitative analysis of the sugar alcohol xylitol as well as the determination of the maximal loading capacity was performed by gas chromatography in conjunction with mass spectrometric detection after chemical derivatization. In a parallel approach quantum mechanical geometry optimizations were performed in order to compare the coordination behavior of various trivalent lanthanide ions. PMID:24097333

  5. INFLUENCE OF CHITOSAN ON CARBOHYDRATE METABOLISM IN EXERCISING MICE

    Institute of Scientific and Technical Information of China (English)

    石磊; 黄伟

    2004-01-01

    Objective To study the mechanism of chitosan on carbohydrate metabolism disorder in exercising mice. Methods The animal model of carbohydrate metabolism disorder was established through swimming trainings and the content of blood glucose, muscle glycogen and liver glycogen in mice were all surveyed. Results When quiet, liver glycogen, muscle glycogen and blood glucose of drug-taking group were much higher than those of control group(P<0.05). Compared with control group, the liver glycogen and muscle glycogen of instant drug-taking group after exercises level to a higher degree (P<0.05). The renewing level of liver glycogen, muscle glycogen and blood glucose in drug-taking group after spending 24 hours on recovery was evidently higher than that of control-group (P<0.05). The exhaustive swimming time of drug-taking group was longer than that of exercise-control group by 33.99%. Conclusion Chitosan takes good effect on improving carbohydrate metabolism disorder resulting from exercises.

  6. Carbohydrate metabolism of cactus in a desert environment.

    Science.gov (United States)

    Sutton, B G

    1981-09-01

    The concentration of glucan, mucilage, soluble carbohydrates, and malic acid were determined in Opuntia bigelovii Engelm. during a 23-week period. The experiment began during the dry summer by irrigation to stimulate Crassulacean acid metabolism and was followed by 13 weeks of drought. After the 13-week drought period, the plants were irrigated throughout a 10-week period until late December. The maximum level of malic acid determined each day at dawn decreased throughout the drought period and increased after irrigation. High levels of malic acid occurring at dawn are indicative of active Crassulacean acid metabolism. Soluble carbohydrates also decreased during drought and increased after irrigation. Both glucan and mucilage increased slightly for about 9 weeks during the drought period and then began to decrease. Irrigation was accompanied by a further decrease in concentration of glucan and mucilage. Since both glucan and mucilage changed in a similar manner and since their concentrations in the tissue are correlated, it is hypothesized that both function as storage carbohydrates. Whereas glucan is the nocturnal substrate for malic acid synthesis, there are no data to support or refute a similar hypothesis for mucilage. PMID:16661999

  7. Improved evaporative light scattering detection for carbohydrate analysis.

    Science.gov (United States)

    Condezo-Hoyos, Luis; Pérez-López, Elena; Rupérez, Pilar

    2015-08-01

    Optimization and validation of evaporative light scattering detector (ELSD), aided by response surface methodology (RSM), has been developed for the liquid chromatography analysis of a wide molecular weight (MW) range of carbohydrates, including polysaccharides and oligosaccharides. Optimal experimental parameters for the ELSD detection were: 88.8°C evaporator temperature, 77.9°C nebulizer temperature and 1.1 standard litres per minute nitrogen flow rate. Optimal ELSD detection, used together with high performance size exclusion chromatography (HPSEC) of carbohydrates, gave a linear range from 250 to 1000 mg L(-1) (R(2)>0.998), with limits of detection and quantitation of 4.83-11.67 and 16.11-38.91 mg L(-1), respectively. Relative standard deviation was lower than 1.8% for intra-day and inter-day repeatability for apple pectin, inulin, verbascose, stachyose and raffinose. Recovery ranged from 103.7% to 118.3% for fructo-oligosaccharides, α-galacto-oligosaccharides and disaccharides. Optimized and validated ELSD detection is proposed for the analysis of high- to low-MW carbohydrates with high sensitivity, precision and accuracy. PMID:25766827

  8. Short-chain carbohydrates and functional gastrointestinal disorders.

    Science.gov (United States)

    Shepherd, Susan J; Lomer, Miranda C E; Gibson, Peter R

    2013-05-01

    Carbohydrates occur across a range of foods regularly consumed including grains such as wheat and rye, vegetables, fruits, and legumes. Short-chain carbohydrates with chains of up to 10 sugars vary in their digestibility and subsequent absorption. Those that are poorly absorbed exert osmotic effects in the intestinal lumen increasing its water volume, and are rapidly fermented by bacteria with consequent gas production. These two effects alone may underlie most of the induction of gastrointestinal symptoms after they are ingested in moderate amounts via luminal distension in patients with visceral hypersensitivity. This has been the basis of the use of lactose-free diets in those with lactose malabsorption and of fructose-reduced diets for fructose malabsorption. However, application of such dietary approaches in patients with functional bowel disorders has been restricted to observational studies with uncertain efficacy. As all dietary poorly absorbed short-chain carbohydrates have similar and additive effects in the intestine, a concept has been developed to regard them collectively as FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) and to evaluate a dietary approach that restricts them all. In patients with irritable bowel syndrome, there is now an accumulating body of evidence, based on observational and comparative studies, and on randomized-controlled trials that supports the notion that FODMAPs trigger gastrointestinal symptoms in patients with functional bowel disorders, and that a diet low in FODMAPs offers considerable symptom relief in the majority of patients who use it. PMID:23588241

  9. Secretion of glucose in human parotid saliva after carbohydrate intake.

    Science.gov (United States)

    Borg, A; Birkhed, D

    1988-12-01

    The aims of the present investigation were, first, to follow the secretion of free glucose in parotid saliva in various subjects after a single oral intake of different carbohydrates, and second, to compare the salivary glucose concentration with the concentration in blood. Twenty healthy subjects, three women and 17 men, 20-35 yr of age, participated. They were asked not to eat or drink anything from 10 p.m. the night before the examination. 75 g of carbohydrate (glucose, fructose, or sucrose) dissolved in 300 ml water was ingested the next morning at 8 a.m. One experimental series with glucose was performed in triplicate in 10 of the subjects. Approximately 1.5 ml of citric acid-stimulated parotid saliva was collected before (0 min) and 15, 30, 45, 60, and 120 min after the intake. Salivary concentration of glucose was analyzed enzymatically. Most of the 0-min samples showed a variation in glucose concentration from 5 to 25 mumol/l. After the glucose, fructose, and sucrose intakes, the salivary glucose level increased about 2-4 times, especially in the 30-min samples. A large inter- as well as intra-individual variation was found both in the 0-min samples and in the samples collected after the different intakes. The correlation between the glucose concentration in saliva and blood was higher after than before the carbohydrate intakes. PMID:3206201

  10. Mutagenicity of quaternary ammonium salts containing carbohydrate moieties

    International Nuclear Information System (INIS)

    Highlights: → A series of quaternary ammonium salts containing carbohydrate moieties, with configuration D-galacto, D-gluco and D-manno, was synthesized and characterized. → The quaternary ammonium salts containing carbohydrate moieties revealed potent mutagenic activities, as assessed by using the Vibrio harveyi bioluminescence mutagenicity test. → The N-[2-(D-glycopyranosyloxy)ethyl]-N,N,N-trimethylaminium salts were of the highest activity in the mutagenicity assay. → We suggest that quaternary ammonium salts may be more hazardous than previously supposed. - Abstract: Quaternary ammonium salts are widely used in industrial, agricultural, healthcare and domestic applications. They are believed to be safe compounds, with little or no health hazard to humans. However, in this report, we demonstrate that a series of newly synthesized quaternary ammonium salts containing carbohydrate moieties reveal potent mutagenic activities, as assessed by using the Vibrio harveyi bioluminescence mutagenicity test. D-Gluco- and D-galacto-derivatives were found to have a higher mutagenic potential than D-manno-derivatives. Among the former groups of compounds, the N-[2-(D-glycopyranosyloxy)ethyl]-N,N,N-trimethylaminium salts were of the highest activity in the mutagenicity assay. These results suggest that the safety of quaternary ammonium salts may be lower than previously supposed, indicating a need for testing such compounds for their mutagenicity.

  11. Mutagenicity of quaternary ammonium salts containing carbohydrate moieties

    Energy Technology Data Exchange (ETDEWEB)

    Dmochowska, Barbara [Department of Carbohydrate Chemistry, University of Gdansk, Sobieskiego 18, 80-952 Gdansk (Poland); Piosik, Jacek; Woziwodzka, Anna [Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Kladki 24, 80-822 Gdansk (Poland); Sikora, Karol; Wisniewski, Andrzej [Department of Carbohydrate Chemistry, University of Gdansk, Sobieskiego 18, 80-952 Gdansk (Poland); Wegrzyn, Grzegorz, E-mail: wegrzyn@biotech.univ.gda.pl [Department of Molecular Biology, University of Gdansk, Kladki 24, 80-822 Gdansk (Poland)

    2011-10-15

    Highlights: {yields} A series of quaternary ammonium salts containing carbohydrate moieties, with configuration D-galacto, D-gluco and D-manno, was synthesized and characterized. {yields} The quaternary ammonium salts containing carbohydrate moieties revealed potent mutagenic activities, as assessed by using the Vibrio harveyi bioluminescence mutagenicity test. {yields} The N-[2-(D-glycopyranosyloxy)ethyl]-N,N,N-trimethylaminium salts were of the highest activity in the mutagenicity assay. {yields} We suggest that quaternary ammonium salts may be more hazardous than previously supposed. - Abstract: Quaternary ammonium salts are widely used in industrial, agricultural, healthcare and domestic applications. They are believed to be safe compounds, with little or no health hazard to humans. However, in this report, we demonstrate that a series of newly synthesized quaternary ammonium salts containing carbohydrate moieties reveal potent mutagenic activities, as assessed by using the Vibrio harveyi bioluminescence mutagenicity test. D-Gluco- and D-galacto-derivatives were found to have a higher mutagenic potential than D-manno-derivatives. Among the former groups of compounds, the N-[2-(D-glycopyranosyloxy)ethyl]-N,N,N-trimethylaminium salts were of the highest activity in the mutagenicity assay. These results suggest that the safety of quaternary ammonium salts may be lower than previously supposed, indicating a need for testing such compounds for their mutagenicity.

  12. Shape: automatic conformation prediction of carbohydrates using a genetic algorithm

    Directory of Open Access Journals (Sweden)

    Rosen Jimmy

    2009-09-01

    Full Text Available Abstract Background Detailed experimental three dimensional structures of carbohydrates are often difficult to acquire. Molecular modelling and computational conformation prediction are therefore commonly used tools for three dimensional structure studies. Modelling procedures generally require significant training and computing resources, which is often impractical for most experimental chemists and biologists. Shape has been developed to improve the availability of modelling in this field. Results The Shape software package has been developed for simplicity of use and conformation prediction performance. A trivial user interface coupled to an efficient genetic algorithm conformation search makes it a powerful tool for automated modelling. Carbohydrates up to a few hundred atoms in size can be investigated on common computer hardware. It has been shown to perform well for the prediction of over four hundred bioactive oligosaccharides, as well as compare favourably with previously published studies on carbohydrate conformation prediction. Conclusion The Shape fully automated conformation prediction can be used by scientists who lack significant modelling training, and performs well on computing hardware such as laptops and desktops. It can also be deployed on computer clusters for increased capacity. The prediction accuracy under the default settings is good, as it agrees well with experimental data and previously published conformation prediction studies. This software is available both as open source and under commercial licenses.

  13. Postmenopausal osteoporosis - clinical, biological and histopathological aspects.

    Science.gov (United States)

    Pavel, Oana Roxana; Popescu, Mihaela; Novac, Liliana; Mogoantă, LaurenŢiu; Pavel, LaurenŢiu Petrişor; Vicaş, Răzvan Marius; Trăistaru, Magdalena Rodica

    2016-01-01

    Osteoporosis is one of the most common disorders in postmenopausal women, affecting the quality of life and increasing the risk for fractures in minor traumas. Changes in the bone microarchitecture causes static changes in the body and affects motility. In this study, we analyzed two groups of women, one with physiological menopause and one with surgically induced menopause. The diagnosis of osteoporosis was suspected based on the clinical symptoms and confirmed by assessing bone mineral density by the dual-energy X-ray absorptiometry (DEXA). Comparing some clinical and biological aspects there was noted that a much higher percentage of women with surgically induced menopause exhibited increases in body mass index, changes in serum lipids, cholesterol, triglycerides, blood glucose, serum calcium, magnesemia and osteocalcin. In contrast, no significant differences were observed in the histopathological aspects of bone tissue examined from these two groups. In all patients, there was identified a significant reduction in the number of osteocytes and osteoblasts, the expansion of haversian channels, reducing the number of trabecular bone in the cancellous bone with wide areola cavities often full of adipose tissue, non-homogenous demineralization of both the compact bone and the cancellous bone, atrophy and even absence of the endosteal, and the presence of multiple microfractures. Our study showed that early surgically induced menopause more intensely alters the lipid, carbohydrate and mineral metabolism, thus favoring the onset of osteoporosis. PMID:27151697

  14. Carbohydrate/glycan-binding specificity of legume lectins in respect to their proposed biological functions

    Directory of Open Access Journals (Sweden)

    Márcio Viana Ramos

    2000-01-01

    Full Text Available The lectins, proteins which specifically recognize carbohydrate moieties, have been extensively studied in many biochemical and structural aspects in order to establish the molecular basis of this non-catalytic event. On the other hand, their clinical and agricultural potentials have been growing fast. Although lectins, mainly those from legume plants, had been investigated for biological properties, studies about the physiological functions of lectins are scarce in literature. Therefore, despite the accumulated data on lectins (as proteins, the role played by these signalizing molecules is poorly discussed. In the light of our accumulated results on legume lectins, specially those obtained from plants belonging to the Diocleinae sub-tribe and available data in literature, we discuss here the main hypothesis of their functions according to their carbohydrate/glycan-binding specificity.As lectinas, proteinas que especificamente reconhecem estruturas que contém carboidratos, têm sido extensivamente estudadas em muitos aspectos bioquímicos e estruturais, objetivando estabelecer as bases moleculares deste evento não-catalítico. Por outro lado, os potenciais clínicos e agriculturais destas proteínas têm crescido rapidamente. Embora as lectinas, principalmente aquelas de legumes tenham sido bastante investigadas em suas propriedades biológicas, estudos sobre as funcões fisiológicas de lectinas são escassos na literatura. Além disto, a despeito da quantidade de dados acumulados sobre lectinas (como proteínas, o papel desempenhado por estas moléculas de sinalização é pobremente discutido. Valendo-se de nossos estudos sobre lectinas de leguminosas, principalmente da sub-tribo Diocleinae, e outros dados presentes na literatura, discutimos aqui, as principais hipóteses de suas funções com base na especificidade por carboidratos e glicanos complexos.

  15. Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis.

    Science.gov (United States)

    Rühmann, Broder; Schmid, Jochen; Sieber, Volker

    2016-01-01

    Many microorganisms are capable of producing and secreting exopolysaccharides (EPS), which have important implications in medical fields, food applications or in the replacement of petro-based chemicals. We describe an analytical platform to be automated on a liquid handling system that allows the fast and reliable analysis of the type and the amount of EPS produced by microorganisms. It enables the user to identify novel natural microbial exopolysaccharide producers and to analyze the carbohydrate fingerprint of the corresponding polymers within one day in high-throughput (HT). Using this platform, strain collections as well as libraries of strain variants that might be obtained in engineering approaches can be screened. The platform has a modular setup, which allows a separation of the protocol into two major parts. First, there is an automated screening system, which combines different polysaccharide detection modules: a semi-quantitative analysis of viscosity formation via a centrifugation step, an analysis of polymer formation via alcohol precipitation and the determination of the total carbohydrate content via a phenol-sulfuric-acid transformation. Here, it is possible to screen up to 384 strains per run. The second part provides a detailed monosaccharide analysis for all the selected EPS producers identified in the first part by combining two essential modules: the analysis of the complete monomer composition via ultra-high performance liquid chromatography coupled with ultra violet and electrospray ionization ion trap detection (UHPLC-UV-ESI-MS) and the determination of pyruvate as a polymer substituent (presence of pyruvate ketal) via enzymatic oxidation that is coupled to a color formation. All the analytical modules of this screening platform can be combined in different ways and adjusted to individual requirements. Additionally, they can all be handled manually or performed with a liquid handling system. Thereby, the screening platform enables a huge

  16. Microalgal carbohydrates: an overview of the factors influencing carbohydrates production, and of main bioconversion technologies for production of biofuels

    DEFF Research Database (Denmark)

    Markou, Giorgos; Angelidaki, Irini; Georgakakis, Dimitris

    2012-01-01

    research is the cultivation of microalgae for lipids production to generate biodiesel. However, there are several other biological or thermochemical conversion technologies, in which microalgal biomass could be used as substrate. However, the high protein content or the low carbohydrate content of the......Microalgal biomass seems to be a promising feedstock for biofuel generation. Microalgae have relative high photosynthetic efficiencies, high growth rates, and some species can thrive in brackish water or seawater and wastewater from the food- and agro-industrial sector. Today, the main interest in...... majority of the microalgal species might be a constraint for their possible use in these technologies. Moreover, in the majority of biomass conversion technologies, carbohydrates are the main substrate for production of biofuels. Nevertheless, microalgae biomass composition could be manipulated by several...

  17. Patient Compliance and Medication Perception.

    Science.gov (United States)

    Buckalew, L. W.; Sallis, R. E.

    1986-01-01

    Addresses problem of patient noncompliance with regimens of prescribed medication, with attention to incidence and illogical nature of this behavior. Psychological theory of cognitive dissonance is suggested as appropriate to understanding some aspects of noncompliance because medicinal preparations represent stimuli that are not necessarily…

  18. General safety aspects

    International Nuclear Information System (INIS)

    In this part next aspects are described: (1) Priority to safety; (2) Financial and human resources;; (3) Human factor; (4) Operator's quality assurance system; (5) Safety assessment and Verification; (6) Radiation protection and (7) Emergency preparedness

  19. Foundational aspects of security

    DEFF Research Database (Denmark)

    Chatzikokolakis, Konstantinos; Mödersheim, Sebastian Alexander; Palamidessi, Catuscia;

    2014-01-01

    This Special Issue of the Journal of Computer Security focuses on foundational aspects of security, which in recent years have helped change much of the way we think about and approach system security.......This Special Issue of the Journal of Computer Security focuses on foundational aspects of security, which in recent years have helped change much of the way we think about and approach system security....

  20. PRACTICAL ASPECTS OF MEDIATION

    OpenAIRE

    IULIA FLOCA

    2011-01-01

    Today the Romanian state gives some advantages to those who use mediation. If the Romanian state would take further steps, mediation would work as in the countries with old tradition. The article refers to success and failure got in the two years of practice. The mediation can be seen in two aspects: The first aspect regarding the mediation itself can lead to a mediation agreement. The mediation agreement gives both winnings to the conflict parts and professional satisfactions to the mediator...

  1. Cardiac Medications

    Science.gov (United States)

    ... for Medication For the treatment of heart failure Beta Blockers (Also known as Beta-Adrenergic Blocking Agents) Commonly ... have had a heart attack. Combined alpha and beta-blockers Combined alpha and beta-blockers are used as ...

  2. Medication Treatment

    Science.gov (United States)

    ... behavior, such as to reduce self-injury or aggression. Once a symptom is no longer a problem, ... of repetitive behaviors; decrease anxiety, irritability, tantrums, and aggressive behavior; and improve eye contact. Tricyclics These medications are ...

  3. Taking Medication

    Medline Plus

    Full Text Available ... Tip Sheets and Handouts AADE7 Self-Care Behaviors Healthy Eating Being Active Monitoring Taking Medication Problem Solving Reducing Risks Healthy Coping Education & Career Webinars Upcoming Webinars Recorded Webinars ...

  4. Medication Guide

    Science.gov (United States)

    ... Size Small Text Medium Text Large Text Contrast Dark on Light Light on Dark Donate Search Menu Donate What is Glaucoma? Care ... Low Vision Resources Medication Guide Resources on the Web » See All Articles Help the Cause Glaucoma affects ...

  5. Taking Medication

    Medline Plus

    Full Text Available ... App Tip Sheets and Handouts AADE7 Self-Care Behaviors Healthy Eating Being Active Monitoring Taking Medication Problem Solving Reducing Risks Healthy Coping Education & Career Webinars ...

  6. Medical imaging

    International Nuclear Information System (INIS)

    This didactical book presents the medical imaging techniques: radiography, scanner, nuclear magnetic resonance (NMR). Examples are given for the most common pathologies in all domains of medicine. (J.S.)

  7. Taking Medication

    Medline Plus

    Full Text Available ... Sheets and Handouts AADE7 Self-Care Behaviors Healthy Eating Being Active Monitoring Taking Medication Problem Solving Reducing ... Media Policy | Contact AADE | Sitemap Copyright 2016 AADE Facebook Twitter LinkedIn Pinterest Google Plus Instagram

  8. Taking Medication

    Medline Plus

    Full Text Available ... Tracker App Tip Sheets and Handouts AADE7 Self-Care Behaviors Healthy Eating Being Active Monitoring Taking Medication ... Legislation State Legislation AADE Policy Positions & Statements Affordable Care Act Information Advocacy Tools and Resources Cart Search ...

  9. Medical radiation

    International Nuclear Information System (INIS)

    This leaflet in the At-a-Glance Series describes the medical use of X-rays, how X-rays help in diagnosis, radiation protection of the patient, staff protection, how radioactive materials in nuclear medicine examinations help in diagnosis and the use of radiation in radiotherapy. Magnetic resonance imaging, a diagnostic technique involving no ionizing radiation, is also briefly examined. The role of the NRPB in the medical use of radiation is outlined. (UK)

  10. Medical tourism

    OpenAIRE

    Abbas Ghanbari; Khadijeh Zirak Moradlu; Morteza Ramazani

    2014-01-01

    Medical tourism is considered as one of the tourism dimensions and it can contribute to the stabilized and dynamic development of a country's economy. Since it is cost-effective industry, most developing countries have focused on this industry and they are planning to develop this industry. Not only does Zanjan province, as the central region in medicine services, enjoy different kinds of variety and acceptable medical specialties but also it has historical, natural, and religious tourism pot...

  11. Medical Tourism in Malaysia: Prospect and Challenges

    Science.gov (United States)

    2013-01-01

    Background: Tourism, combined with the phrase medical, seems to be a new form of tourism which has gained huge popularity in recent decades. Though, a number of literatures available with regard to the tourism industry and the competitiveness of the destination, however, the major aspects which determine the satisfaction of medical tourists are hardly focused specifically on Malaysia. There is a lack of empirical evidence in this area of study which needs to be bridged. Hence, this study aimed at investigating the various factors contributing towards the development of medical tourism in Malaysia. Methods: As the purpose of the research was to find out various factors contributing towards the development of medical tourism in Malaysia, so this study used Structural Equation modeling (SEM) for data analysis. The target population for this study consisted of the medical tourists coming to Malaysia with the primary intension of seeking medical procedures other than sightseeing. A total sample size of 266 was collected through non-probability judgment sampling during the period between December 2012 and February 2013. Results: The result confirms that destination competitiveness and service quality play an important role in the medical tourist’s mind towards medical tourism aspect in Malaysia. Thus, Malaysia need to promote various medical success stories together with the services they offer to attract more foreign patients. Conclusion: This study contributes to the theoretical development in the tourism industry by offering the structured relationship among various aspects contributing towards the development of medical tourism in Malaysia. PMID:26056632

  12. Carbohydrate Content in the GDM Diet: Two Views: View 2: Low-Carbohydrate Diets Should Remain the Initial Therapy for Gestational Diabetes.

    Science.gov (United States)

    Mulla, Wadia R

    2016-05-01

    IN BRIEF The appropriate dietary intervention for gestational diabetes mellitus (GDM) is not clear. Traditionally, a low-carbohydrate diet has been prescribed. Recently, there has been a movement to prescribe a diet higher in nutrient-dense carbohydrate as the initial treatment for GDM. At this time, there is insufficient outcome data to support this type of diet. PMID:27182177

  13. Does Exogenous Application of Kinetin and Spermine Mitigate the Effect of Seawater on Yield Attributes and Biochemical Aspects of Grains?

    OpenAIRE

    Heshmat S. Aldesuquy; Baka, Zakaria A.; Mickky, Bardees M.

    2013-01-01

    A pot experiment was conducted to evaluate the effect of grain presoaking in kinetin (0.1 mM), spermine (0.3 mM) and their interaction on yield components and biochemical aspects of yielded grains of wheat plants irrigated with 25% seawater. Seawater induced marked reduction in biochemical aspects of yielded grains especially carbohydrates content, nitrogenous constituents, total protein and nucleic acids contents as well as proline and organic acids (citric and keto acids) contents. Converse...

  14. Seasonal influences on carbohydrate metabolism in the CAM bromeliad Aechmea ‘Maya’: consequences for carbohydrate partitioning and growth

    Science.gov (United States)

    Ceusters, Johan; Borland, Anne M.; Ceusters, Nathalie; Verdoodt, Veerle; Godts, Christof; De Proft, Maurice P.

    2010-01-01

    Background and Aims Photosynthetic plasticity in response to a range of environmental factors that include [CO2], water availability, light intensity and temperature, is ubiquitous among plants with crassulacean acid metabolism (CAM). The present study examined how seasonal changes in light availability, as experienced by greenhouse CAM crops in northern latitude regions, influence diel carboxylation patterns and impact on carbon gain and seasonal accumulation of biomass. Methods In the CAM bromeliad Aechmea ‘Maya’ integrated measurements of leaf gas exchange, diel metabolite dynamics (e.g. malate, soluble sugars and starch) and biomass accumulation were made four times a year, i.e. in winter, spring, summer and autumn. Key Results During the brighter seasons (spring and summer) daytime Phases II and IV were dominated by C4 carboxylation, whilst the higher diurnal uptake in the autumn and winter was characterized by equal contributions of both Rubisco and PEPC. As a consequence, net CO2 uptake showed a significant depression at the end of the day in the darker months when supplementary illumination was turned off. Remarkable seasonal consistency was found in the amount of storage reserves available for nocturnal carboxylation, a consequence of predominantly daytime export of carbohydrate in spring and summer whilst nocturnal export was the major sink for carbohydrate in autumn and winter. Conclusions Throughout the different seasons Aechmea ‘Maya’ showed considerable plasticity in the timing and magnitude of C3 and C4 carboxylation processes over the diel cycle. Under low PPFD (i.e. winter and autumn) it appears that there was a constraint on the amount of carbohydrate exported during the day in order to maintain a consistent pool of transient carbohydrate reserves. This gave remarkable seasonal consistency in the amount of storage reserves available at night, thereby optimizing biomass gain throughout the year. The data have important practical

  15. Evolving dimensions in medical case reporting

    Directory of Open Access Journals (Sweden)

    Athanasiou Thanos

    2011-04-01

    Full Text Available Abstract Medical case reports (MCRs have been undervalued in the literature to date. It seems that while case series emphasize what is probable, case reports describe what is possible and what can go wrong. MCRs transfer medical knowledge and act as educational tools. We outline evolving aspects of the MCR in current practice.

  16. A computational approach for exploring carbohydrate recognition by lectins in innate immunity

    Directory of Open Access Journals (Sweden)

    Mark eAgostino

    2011-06-01

    Full Text Available Recognition of pathogen-associated carbohydrates by a broad range of carbohydrate binding proteins is central to both adaptive and innate immunity. A large functionally diverse group of mammalian carbohydrate binding proteins are lectins, which often display calcium-dependent carbohydrate interactions mediated by one or more carbohydrate recognition domains. We report here the application of molecular docking and site mapping to study carbohydrate recognition by several lectins involved in innate immunity or in modulating adaptive immune responses. It was found that molecular docking programs can identify the correct carbohydrate binding mode, but often have difficulty in ranking it as the best pose. This is largely attributed to the broad and shallow nature of lectin binding sites, and the high flexibility of carbohydrates. Site mapping is very effective at identifying lectin residues involved in carbohydrate recognition, especially with cases that were found to be particularly difficult to characterize via molecular docking. This study highlights the need for alternative strategies to examine carbohydrate-lectin interactions, and specifically demonstrates the potential for mapping methods to extract additional and relevant information from the ensembles of binding poses generated by molecular docking.

  17. Veterinary and medical aspects of abortion in Danish sheep

    DEFF Research Database (Denmark)

    Agerholm, Jørgen S.; Aalbæk, Bent; Fog-Larsen, Anne Marie;

    2006-01-01

    The Danish sheep population totals around 144,000 animals, but little is known of the causes and prevalance of diseases. This study focuses on the causes of abortion in Danish sheep. During one breeding season, aborted foetuses and stillbirths with signs of intrauterine death or malformation were...

  18. Tryptophan Biochemistry: Structural, Nutritional, Metabolic, and Medical Aspects in Humans

    OpenAIRE

    Lionella Palego; Laura Betti; Alessandra Rossi; Gino Giannaccini

    2016-01-01

    L-Tryptophan is the unique protein amino acid (AA) bearing an indole ring: its biotransformation in living organisms contributes either to keeping this chemical group in cells and tissues or to breaking it, by generating in both cases a variety of bioactive molecules. Investigations on the biology of Trp highlight the pleiotropic effects of its small derivatives on homeostasis processes. In addition to protein turn-over, in humans the pathways of Trp indole derivatives cover the synthesis of ...

  19. Twenty Two Years after Chernobyl Accident Medical Aspect

    International Nuclear Information System (INIS)

    Chernobyl accident is the most serious nuclear catastrophe in the recent era. About 600.000 victims intervene in this disaster. The most fatality was about one month after the accident 31 victims. The main cause was Acute Radiation Syndrome. After few weeks 115.000 persons evacuated from the contaminated areas with exposure dose from 0.07 to 2 Gy. The main Isotope exposure was iodine 131 and Cesium 137 with average exposure dose 7 and 10 mGy respectively

  20. The Loss of HMAS Sydney II: Medical Aspects

    Directory of Open Access Journals (Sweden)

    Neil Westphalen

    2011-07-01

    Full Text Available On 19 November 1941, HMAS Sydney was 100nm off Shark Bay, on her way back to Fremantle after escorting the troopship Zealandia to Sunda Strait, between Java and Sumatra. At 1600 she encountered the German auxiliary cruiser Kormoran. The ensuring battle began at 1730 and ended at 1825. Sydney was last seen on fire at 2300 while Kormoran was scuttled and sank just after midnight. There were 318 survivors from Kormoran’s crew of 399, but no survivors from Sydney’s crew of 645. Both wrecks were found in March 2008 and this led to a Commission of Inquiry to address the various controversies and conspiracy theories related to Sydney’s loss.

  1. Medical and related aspects of the Goiania accident: An overview

    International Nuclear Information System (INIS)

    On 13 September 1987, a radiation accident occurred in the city of Goiania in Central Brazil. Approximately 250 people were exposed to a 137Cs source from an abandoned radiotherapy unit. At least 14 patients showed some degree of bone marrow depression, and eight developed the classical signs and symptoms of acute radiation syndrome (ARS). Twenty-eight people presented local radiation injuries ranging from first to third degree, and 104 individuals showed evidence of internal contamination. This paper describes the circumstances of the event, the first-aid measures taken, the criteria adopted for triage of the exposed population, and the radiation protection procedures used during the clinical management of the irradiated individuals

  2. Topical aspects of nuclear medical diagnostics in dermatology

    International Nuclear Information System (INIS)

    The diagnostic value of soft tissue and bone scintigraphy in various dermatological diseases is discussed. We received new knowledge about frequency, dimension and validity of psoriatic osteoarthropathia by using scintigraphic methods. Bone scintigraphy is more sensitive than clinical and radiological investigation and there is an earlier detection of arthropathy in psoriasis. Whole body scintigraphy using bone seeking radiopharmaceuticals has proven to be a sensitive diagnostic tool in the detection of bone and joint involvement in collagen diseases. These methods can also be of great value in the evaluation and clinical management of diseases with possible generalized or multiple bone lesions (e. g. syphilis; dermatomyositis; sarcoidosis; malignant melanoma). Since the discovery of hybridoma technique for the production of monoclonal antibodies it became apparent that this new class of immunoglobulins may represent a new useful tool in the diagnosis and in the therapy of malignant diseases. In this paper we discuss the application of murine and human monoclonal antibodies in experimental and clinical oncology. (orig.)

  3. Medical aspects of boron-slow neutron capture therapy

    International Nuclear Information System (INIS)

    Earlier radiations of patients with cerebral tumors disclosed the need: (1) to find a carrier of the boron compound which would leave the blood and concentrate in the tumor, (2) to use a more penetrating neutron beam, and (3) to develop a much faster method for assaying boron in blood and tissue. To some extent number1 has been accomplished in the form of Na2 B12 H11 SH, number2 has yet to be achieved, and number3 has been solved by the measurement of the 478-keV gamma ray when the 10B atom disintegrates following its capture of a slow neutron. The hitherto unreported data in this paper describe through the courtesy of Professor Hiroshi Hatanaka his studies on the pharmacokinetics and quality control of Na2 B12 H11SH based on 96 boron infusions in 86 patients. Simultaneous blood and tumor data are plotted here for 30 patients with glioblastomas (Grade III-IV gliomas), illustrating remarkable variability. Detailed autopsy findings on 18 patients with BNCT showed radiation injury in only 1. Clinical results in 12 of the most favorably situated glioblastomas reveal that 5 are still alive with a 5-year survival rate of 58% and the excellent Karnofsky performance rating of 87%. For the first time evidence is presented that slow-growing astrocytomas may benefit from BNCT. 10 references, 8 figures, 5 tables

  4. Selected methodological aspects of routine medical supervision of radiation workers

    International Nuclear Information System (INIS)

    Examinations of the blood, skin, chromosomes, eyes and lungs provide an important means for detecting biological radiation effects in occupationally exposed workers. The diagnostic value of these five methods is discussed. (author)

  5. Rembrandt's Late Self-Portraits: Psychological and Medical Aspects

    Science.gov (United States)

    Marcus, Esther-Lee; Clarfield, A. Mark

    2002-01-01

    The Dutch painter Rembrandt (1606-1669) left behind the largest series of self-portraits in the history of art. These paintings were produced over a period of time from age 22 years until just a few months before Rembrandt's death at age 63. This series gives us a unique opportunity to explore the development, maturity, and aging of the artist.…

  6. Tryptophan Biochemistry: Structural, Nutritional, Metabolic, and Medical Aspects in Humans.

    Science.gov (United States)

    Palego, Lionella; Betti, Laura; Rossi, Alessandra; Giannaccini, Gino

    2016-01-01

    L-Tryptophan is the unique protein amino acid (AA) bearing an indole ring: its biotransformation in living organisms contributes either to keeping this chemical group in cells and tissues or to breaking it, by generating in both cases a variety of bioactive molecules. Investigations on the biology of Trp highlight the pleiotropic effects of its small derivatives on homeostasis processes. In addition to protein turn-over, in humans the pathways of Trp indole derivatives cover the synthesis of the neurotransmitter/hormone serotonin (5-HT), the pineal gland melatonin (MLT), and the trace amine tryptamine. The breakdown of the Trp indole ring defines instead the "kynurenine shunt" which produces cell-response adapters as L-kynurenine, kynurenic and quinolinic acids, or the coenzyme nicotinamide adenine dinucleotide (NAD(+)). This review aims therefore at tracing a "map" of the main molecular effectors in human tryptophan (Trp) research, starting from the chemistry of this AA, dealing then with its biosphere distribution and nutritional value for humans, also focusing on some proteins responsible for its tissue-dependent uptake and biotransformation. We will thus underscore the role of Trp biochemistry in the pathogenesis of human complex diseases/syndromes primarily involving the gut, neuroimmunoendocrine/stress responses, and the CNS, supporting the use of -Omics approaches in this field. PMID:26881063

  7. Common Pediatric Disabilities: Medical Aspects and Educational Implications.

    Science.gov (United States)

    Tyler, Janet Siantz; Colson, Steven

    1994-01-01

    This paper presents definitions of common pediatric disabilities and information about incidence, causes, diagnosis, common characteristics, complications with educational implications, and multidisciplinary intervention approaches. It covers the following conditions: attention deficit hyperactivity disorder, cerebral palsy, Down syndrome, fragile…

  8. General medical and related aspects of the Goiania accident, Brazil

    International Nuclear Information System (INIS)

    In a recent radiation accident occurred in the city of Goiania, central area of Brazil, approximately 250 people were exposed to a 137Cs source from a radiotherapy unit abandoned in a amedical clinic in that city. At least twelve patients showed some degree of bone marrow depression, from which eight developed the classical signs and symptoms of Acute radiation Syndrome (ARS). 28 people presented local radiation burns ranging from first to third degree. Around 100 people showed evidences of internal contamination due to the dissemination of the source powder. The authors describe the circumstances of the event, the first-aid measures taken at place, the criteria adopted during the triage of victims and the radiation protection procedures used during the management and treatment of the irradiated individuals. (author)

  9. The biochemical, pathophysiological, and medical aspects of ubiquinone function.

    Science.gov (United States)

    Nohl, H; Gille, L; Staniek, K

    1998-11-20

    Ubiquinone (Q) shares its biological implication in membrane-associated redox reactions with a variety of other redox carriers, such as dehydrogenases, non-heme-iron proteins, and cytochromes. Peculiarities arise from the lack of transition metals, which in contrast to the other electron carriers do not participate in redox-shuttle activities of Q. Another peculiarity is the lipophilicity of Q, which allows free movement between reductants and oxidants of a membrane. The chemistry of Q reduction and ubiquinol oxidation requires the stepwise acceptance and transfer of two single electrons associated with the addition or release of two single H+. These special qualities are widely used in biological membranes for linear electron transfer and transmembranous H+ translocation. In mitochondria it was long reported that under certain conditions linear e- transfer from the semireduced form (SQ.) to native oxidants of the respiratory chain may run out of control, thereby establishing a permanent source of oxygen radical release. It should be mentioned that in mitochondria e- transfer to dioxygen out of sequence requires a particular treatment with inhibitors and uncouplers of the respiratory chain. Nevertheless, it is generally assumed that Q is mainly involved in mitochondrial O2.- generation and that mitochondria represent the major source of O2.- radicals under physiological and various pathophysiological conditions. The ever-increasing application of coenzyme Q as an antioxidant for the prophylaxis and treatment of a great variety of functional disorders, including senescence, has considerably stimulated our interest in the potential prooxidative potency of this natural electron carrier. Experimental evidence will be presented that under physiological conditions Q implicated in mitochondrial e- transfer of the respiratory chain is not involved in cellular oxygen activation. It will also be shown that alterations of Q from an e- carrier to an active radical promotor is possible under various conditions. In addition, reaction products emerging from the antioxidant activity of ubiquinol were found to stimulate the formation of inorganic as well as organic oxygen radicals. PMID:9928447

  10. [Abortion in Colombia. Medical, legal and socioeconomic aspects].

    Science.gov (United States)

    Umaña, A O

    1973-01-01

    Abortion is a social problem and criminal sanctions are very ineffective in limiting it and are seldom applied (133 legal actions vs. 65,600 cases of induced abortion in 1965). Abortion is a social disease, as are prostitution, juvenile delinquency, drug abuse, and so far has been an insoluble problem. Colombian laws should be modified to reflect reality. Sex education must be emphasized, because ignorance is one of the main causes of abortion. Leniency should be applied toward women who cooperate with the authorities in identifying the person who performed an abortion. Legalization of abortion and enforcement of strict laws against it are considered as possible solutions, but both are rejected. The former is regarded as morally unacceptable and as imposing an excessive burden on scarce health services, the latter as even worse, imposing an equivalent burden on the court system, without s olving either health or social problems. The best and probably only solution is to improve education in family planning, to promote knowledge and motivation to enable the population to make sound and responsible decisions. PMID:4804875

  11. Predicting patient attitudes to asthma medication.

    OpenAIRE

    Osman, L M; Russell, I.T.; Friend, J. A.; Legge, J. S.; Douglas, J G

    1993-01-01

    BACKGROUND--Studies of patient attitudes to asthma and its control have focused on crisis action, and little attention has been paid to attitudes to regular preventive medication. It is not clear whether attitudes to regular medication are related to the degree of distress or interference with life perceived by patients as being caused by their asthma. For this reason this study examined how far dislike of medication related to dislike of other aspects of interference of asthma with daily lif...

  12. Medical migration.

    Science.gov (United States)

    Loefler, I J

    2001-10-01

    The issue of professional migration, however emotional it may have become, ought not to be regarded in moralizing terms. The history of western medicine is the history of migrating physicians. A doctor who moves from a locality to another to take up a new assignment there cannot be said to have "abandoned his patients". This emotional bond has become the victim of specialization and of depersonalization of medical services and not of medical migration, brain drain or otherwise. The primary reason for medical migration is not financial; the desire to migrate usually begins with the desire to learn. Professionals crave in the first line for professional satisfaction. The migration of medical manpower cannot be stopped with administrative measures and will not be stopped by exhortations and appeals, moralization and condemnations. Brain drain is a global phenomenon and has always been so. A country which loses its professionals, its doctors, should examine the social relationships within the profession and should investigate whether the opportunities for deriving professional satisfaction from everyday work exist or whether these have been thwarted by the hierarchy, conservatism, cronyism and the general lack of comprehension of what good medical care is about. PMID:11593497

  13. Non-alcoholic fatty liver disease and the metabolic syndrome: Effects of weight loss and a review of popular diets. Are low carbohydrate diets the answer?

    Institute of Scientific and Technical Information of China (English)

    Harjot K Gill; George Y Wu

    2006-01-01

    Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of fat-induced liver injury, ranging from relatively benign steatosis to cirrhosis and liver failure.The presence of obesity and insulin resistance is strongly associated with non-alcoholic fatty liver and confers on it a greater risk of histologically advanced disease. There is a growing concern in the medical profession as the prevalence of this disease continues to rise in parallel with the rise in obesity and the metabolic syndrome.Treatment options are limited and dietary weight loss is often advised. Low fat diets are difficult to adhere to and recent studies have shown the potential of low carbohydrate diets for weight loss and improving insulin resistance. Thus far, no study has evaluated the effect of low carbohydrate diets on NAFLD. Future studies will be required to address this question and others with regards to the nutritional adequacy and long-term side effects of these diets.

  14. GLYCAM06: a generalizable biomolecular force field. Carbohydrates.

    Science.gov (United States)

    Kirschner, Karl N; Yongye, Austin B; Tschampel, Sarah M; González-Outeiriño, Jorge; Daniels, Charlisa R; Foley, B Lachele; Woods, Robert J

    2008-03-01

    A new derivation of the GLYCAM06 force field, which removes its previous specificity for carbohydrates, and its dependency on the AMBER force field and parameters, is presented. All pertinent force field terms have been explicitly specified and so no default or generic parameters are employed. The new GLYCAM is no longer limited to any particular class of biomolecules, but is extendible to all molecular classes in the spirit of a small-molecule force field. The torsion terms in the present work were all derived from quantum mechanical data from a collection of minimal molecular fragments and related small molecules. For carbohydrates, there is now a single parameter set applicable to both alpha- and beta-anomers and to all monosaccharide ring sizes and conformations. We demonstrate that deriving dihedral parameters by fitting to QM data for internal rotational energy curves for representative small molecules generally leads to correct rotamer populations in molecular dynamics simulations, and that this approach removes the need for phase corrections in the dihedral terms. However, we note that there are cases where this approach is inadequate. Reported here are the basic components of the new force field as well as an illustration of its extension to carbohydrates. In addition to reproducing the gas-phase properties of an array of small test molecules, condensed-phase simulations employing GLYCAM06 are shown to reproduce rotamer populations for key small molecules and representative biopolymer building blocks in explicit water, as well as crystalline lattice properties, such as unit cell dimensions, and vibrational frequencies. PMID:17849372

  15. Complex carbohydrate utilization by the healthy human microbiome.

    Directory of Open Access Journals (Sweden)

    Brandi L Cantarel

    Full Text Available The various ecological habitats in the human body provide microbes a wide array of nutrient sources and survival challenges. Advances in technology such as DNA sequencing have allowed a deeper perspective into the molecular function of the human microbiota than has been achievable in the past. Here we aimed to examine the enzymes that cleave complex carbohydrates (CAZymes in the human microbiome in order to determine (i whether the CAZyme profiles of bacterial genomes are more similar within body sites or bacterial families and (ii the sugar degradation and utilization capabilities of microbial communities inhabiting various human habitats. Upon examination of 493 bacterial references genomes from 12 human habitats, we found that sugar degradation capabilities of taxa are more similar to others in the same bacterial family than to those inhabiting the same habitat. Yet, the analysis of 520 metagenomic samples from five major body sites show that even when the community composition varies the CAZyme profiles are very similar within a body site, suggesting that the observed functional profile and microbial habitation have adapted to the local carbohydrate composition. When broad sugar utilization was compared within the five major body sites, the gastrointestinal track contained the highest potential for total sugar degradation, while dextran and peptidoglycan degradation were highest in oral and vaginal sites respectively. Our analysis suggests that the carbohydrate composition of each body site has a profound influence and probably constitutes one of the major driving forces that shapes the community composition and therefore the CAZyme profile of the local microbial communities, which in turn reflects the microbiome fitness to a body site.

  16. Carbohydrate protease conjugates: Stabilized proteases for peptide synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Wartchow, C.A.; Wang, Peng; Bednarski, M.D.; Callstrom, M.R. [Ohio State Univ., Columbus, OH (United States)]|[Lawrence Berkeley Lab., CA (United States)

    1995-12-31

    The synthesis of oligopeptides using stable carbohydrate protease conjugates (CPCs) was examined in acetonitrile solvent systems. CPC[{alpha}-chymotrypsin] was used for the preparation of peptides containing histidine, phenylalanine, tryptophan in the P{sub 1} position in 60-93% yield. The CPC[{alpha}-chymotrypsin]-catalyzed synthesis of octamer Z-Gly-Gly-Phe-Gly-Gly-Phe-Gly-Gly-OEt from Z-Gly-Gly-Phe-Gly-Gly-Phe-OMe was achieved in 71% yield demonstrating that synthesis peptides containing both hydrophylic and hydrophobic amino acids. The P{sub 2} specificity of papain for aromatic residues was utilized for the 2 + 3 coupling of Z-Tyr-Gly-OMe to H{sub 2}N-Gly-Phe-Leu-OH to generate the leucine enkephalin derivative in 79% yield. Although papain is nonspecific for the hydrolysis of N-benzyloxycarbonyl amino acid methyl esters in aqueous solution, the rates of synthesis for these derivitives with nucleophile leucine tert-butyl ester differed by nearly 2 orders of magnitude. CPC[thermolysin] was used to prepare the aspartame precursor Z-Asp-Phe-OMe in 90% yield. The increased stability of CPCs prepared from periodate-modified poly(2-methacryl- amido-2-deoxy-D-glucose), poly(2-methacrylamido-2-deoxy-D-galactose), and poly(5-methacryl-amido-5-deoxy-D-ribose), carbohydrate materials designed to increase the aldehyde concentration in aqueous solution, suggests that the stability of CPCs is directly related to the aldehyde concentration of the carbohydrate material. Periodate oxidation of poly(2-methacrylamido-2-deoxy-D-glucose) followed by covalent attachment to {alpha}-chymotrypsin gave a CPC with catalytic activity in potassium phosphate buffer at 90{degrees}C for 2 h. 1 fig., 1 tab., 40 refs.

  17. Lack of effect of high-protein vs. high-carbohydrate meal intake on stress-related mood and eating behavior

    Directory of Open Access Journals (Sweden)

    Lemmens Sofie G

    2011-12-01

    Full Text Available Abstract Background Consumption of meals with different macronutrients, especially high in carbohydrates, may influence stress-related eating behavior. We aimed to investigate whether consumption of high-protein vs. high-carbohydrate meals influences stress-related mood, food reward, i.e. 'liking' and 'wanting', and post-meal energy intake. Methods Participants (n = 38, 19m/19f, age = 25 ± 9 y, BMI = 25.0 ± 3.3 kg/m2 came to the university four times, fasted, once for a stress session receiving a high-protein meal, once for a rest session receiving a high-protein meal, once for a stress session receiving a high-carbohydrate meal and once for a rest session receiving a high-carbohydrate meal (randomized cross-over design. The high-protein and high-carbohydrate test meals (energy percentage protein/carbohydrate/fat 65/5/30 vs. 6/64/30 matched for energy density (4 kJ/g and daily energy requirements (30%. Stress was induced using an ego-threatening test. Pre- and post-meal 'liking' and 'wanting' (for bread, filling, drinks, dessert, snacks, stationery (non-food alternative as control was measured by means of a computer test. Following the post-meal 'wanting' measurement, participants received and consumed their wanted food items (post-meal energy intake. Appetite profile (visual analogue scales, mood state (Profile Of Mood State and State Trait Anxiety Inventory questionnaires, and post-meal energy intake were measured. Results Participants showed increased feelings of depression and anxiety during stress (P Conclusions Consumption of a high-protein vs. high-carbohydrate meal appears to have limited impact on stress-related eating behavior. Only participants with high disinhibition showed decreased subsequent 'wanting' and energy intake during rest; this effect disappeared under stress. Acute stress overruled effects of consumption of high-protein foods. Trial registration The study was registered in the Dutch Trial Register (NTR1904. The

  18. Effects of a Low-carbohydrate Diet on Body Composition

    OpenAIRE

    Engler, Laura

    2003-01-01

    The disturbing trends in increasing numbers of overweight and obese Americans tend not to reflect a lack of effort on the part of the American public to control their weight, but rather a failure to make the attempt in a scientifically sound and effective manner. It may be the frustration associated with this trend that accounts for the popularity of high-fat, low-carbohydrate diets, pushed in books and in the popular media. This paper reviews the physiological basis for these diets, as compa...

  19. Carbohydrate malabsorption in patients with non-specific abdominal complaints

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Non-specific abdominal complaints are a considerable problem worldwide. Many patients are affected and many differential diagnoses have to be considered.Among these, carbohydrate malabsorption seems to play an important role. However, so far, only incomplete absorption of lactose is broadly accepted, while the malabsorption of fructose and sorbitol is still underestimated, although in many parts of the world it is much more frequent. Despite the success of dietary interventions in many patients, there are still a lot of unanswered questions that make further investigations necessary.

  20. Diet and acne update: carbohydrates emerge as the main culprit.

    Science.gov (United States)

    Mahmood, Shereen N; Bowe, Whitney P

    2014-04-01

    The prevalence of adult acne in the US appears to be increasing over the last few decades. But what's behind the rise: is it nature or nurture? We are well aware that genetics can strongly influence a patient's risk of developing acne. However, significant changes in germline genetic variants are unlikely to have occurred over the last 20 years. Consequently, we are forced to examine environmental variables, including diet. This review article presents the most updated evidence supporting a link between refined carbohydrates and acne. Based on the data summarized here, dermatologists should encourage their acne patients to minimize their intake of high glycemic index foods. PMID:24719062

  1. Significance of carbohydrate antigen 50 expression in colorectal carcinoma

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Objective To evaluate the significance of carbohydrate antigen 50(CA50)expression in colorectal carcinoma.Methods Immunohistochemical staining was used to detect CA50 expression in 10 cases of normal colorectal mucosa and 40 cases of cancer mucosa.Results The expression of CA50 increased in normal colorectal mucosa,cancer distant mucosa,cancer adjacent mucosa and cancer mucosa,and there were significant differences among them(P<0.05).The expression of CA50 in colorectal carcinoma was correlated with the deg...

  2. Food-derived carbohydrates--structural complexity and functional diversity.

    Science.gov (United States)

    Tharanathan, Rudrapatnam N

    2002-01-01

    Carbohydrates are biomolecules abundantly available in nature. They are found in bewildering types ranging from simple sugars through oligo- and polysaccharides to glycoconjugates and saccharide complexes, each exhibiting characteristic bio-physiological and/or nutritional functions both in in vivo and in vitro systems. For example, their presence or inclusion in food dictates the texture (body) and gives desirable customer appeal (satisfaction), or their inclusion in the diet offers beneficial effects of great therapeutic value. Thus, carbohydrates are integrally involved in a multitude of biological functions such as regulation of the immune system, cellular signaling (communication), cell malignancy, antiinfection responses, host-pathogen interactions, etc. If starch is considered the major energy storage carbohydrate, the gums/mucilages and other non-starch carbohydrates are of structural significance. The most investigated properties of starch are its gelatinization and melting behavior, especially during food processing. This has led to the development of the food polymer science approach, which has enabled a new interpretive and experimental frame work for the study of the plasticizing influence of simple molecules such as water, sugars, etc. on food systems that are kinetically constrained. Starch, although considered fully digestible, has been challenged, and starch is found to be partly indigestible in the GI tract of humans. This fraction of starch-resisting digestion in vivo is known as resistant starch (RS). The latter, due to its excellent fermentative capacity in the gut, especially yielding butyric acid is considered a new tool for the creation of fiber-rich foods, which are of nutraceutical importance. By a careful control of the processing conditions the content of RS, a man-made fiber, can be increased to as high as 30%. Arabinoxylans are the major endospermic cell wall polysaccharides of cereals. In wheat they are found complexed with ferulic

  3. Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

    Directory of Open Access Journals (Sweden)

    Sílvia H. Cardoso

    2009-01-01

    Full Text Available A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90 in μg/mL. Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL when compared with first line drugs such as isoniazid (INH and rifampicin (RIP and could be a good starting point to develop new compounds against tuberculosis.

  4. Synthesis of γ-Valerolactone from Carbohydrates and its Applications.

    Science.gov (United States)

    Zhang, Zehui

    2016-01-01

    γ-Valerolactone (GVL) is a valuable chemical intermediate that can be obtained by catalytic reduction of levulinic acid (LA) or alkyl levulinates (AL). There are many reports on the synthesis of GVL from LA or AL. However, the demand for the large-scale synthesis of GVL requires more environmentally friendly and cost-effective production processes. This article focuses on the recent advance in the synthesis of GVL from carbohydrates or lignocellulosic biomass. In addition, application of GVL as the reaction solvents, fuel additives, and as precursor for the synthesis of jet fuel and polymer monomers is also discussed. PMID:26733161

  5. Investigations of Reactive Carbohydrates in Glycosidic Bond Formation and Degradation

    DEFF Research Database (Denmark)

    Heuckendorff, Mads

    research was to develop new synthetic methods to evolve the field of synthetic carbohydrate chemistry. In addition, easy methods for obtaining complex oligosaccharides are needed to accommodate biochemical research and drug development. Furthermore, the aim was to shed light on the complex mechanisms of...... configuration and the type of functional group installed on the 2-OH. In Chapter 3 the concepts of conformationally and anchimerically arming were combined in order to achieve the synthesis of a novel donor. The new donor’s capabilities in glycosylations are described. In Chapter 4 a new method for making...

  6. Does carbohydrate supplementation enhance tennis match play performance?

    OpenAIRE

    Gomes, Rodrigo Vitasovic; Capitani, Caroline Dario; Ugrinowitsch, Carlos; Zourdos, Michael Christopher; Fernandez-Fernandez, Jaime; Mendez-Villanueva, Alberto; Aoki, Marcelo Saldanha

    2013-01-01

    Background Carbohydrate (CHO) ingestion may be an interesting approach to avoid significant decrement to the tennis match performance. The aim of the present investigation was to assess the effects of CHO supplementation on tennis match play performance. Methods Twelve young tennis players (18.0 ± 1.0 years; 176 ± 3.4 cm; 68.0 ± 2.3 kg; body fat: 13.7 ± 2.4%) with national rankings among the top 50 in Brazil agreed to participate in this study, which utilized a randomized, crossover, double b...

  7. The Multiple Carbohydrate Binding Specificities of Helicobacter pylori

    Science.gov (United States)

    Teneberg, Susann

    Persistent colonization of the human stomach by Helicobacter pylori is a risk factor for the development of peptic ulcer disease and gastric cancer. Adhesion of microbes to the target tissue is an important determinant for successful initiation, establishment and maintenance of infection, and a variety of different candidate carbohydrate receptors for H. pylori have been identified. Here the different the binding specifities, and their potential role in adhesion to human gastric epithelium are described. Finally, recent findings on the roles of sialic acid binding SabA adhesin in interactions with human neutrophils and erythrocytes are discussed.

  8. A theoretical study of carbohydrates as corrosion inhibitors of iron

    Energy Technology Data Exchange (ETDEWEB)

    Khalil, Salim M.; Ali, Nozha M. [Libyan Academy for Graduate Studies, Tripoli (Libyan Arab Jamahiriya). Chemistry Dept.; Ali-Shattle, Elbashir E. [Tripoli Univ. (Libyan Arab Jamahiriya). Chemistry Dept.

    2013-08-15

    The inhibitive effect of fructose, glucose, lactose, maltose, and sucrose against the iron corrosion is investigated using density functional theory at the B3LYP/6-31 G level (d) to search the relation between the molecular structure and corrosion inhibition. The electronic properties such as the energy of the highest occupied molecular orbital (HOMO), the energy of lowest unoccupied orbital (LUMO), the energy gap (LUMO-HOMO), quantum chemical parameters such as hardness, softness, the fraction of the electron transferred, and the electrophilicity index are reported. The inhibition efficiency of the investigated carbohydrates follows the trend: maltose < sucrose < lactose < fructose < glucose. (orig.)

  9. Modeling of Carbohydrate Binding Modules Complexed to Cellulose

    Energy Technology Data Exchange (ETDEWEB)

    Nimlos, M. R.; Beckham, G. T.; Bu, L.; Himmel, M. E.; Crowley, M. F.; Bomble, Y. J.

    2012-01-01

    Modeling results are presented for the interaction of two carbohydrate binding modules (CBMs) with cellulose. The family 1 CBM from Trichoderma reesei's Cel7A cellulase was modeled using molecular dynamics to confirm that this protein selectively binds to the hydrophobic (100) surface of cellulose fibrils and to determine the energetics and mechanisms for locating this surface. Modeling was also conducted of binding of the family 4 CBM from the CbhA complex from Clostridium thermocellum. There is a cleft in this protein, which may accommodate a cellulose chain that is detached from crystalline cellulose. This possibility is explored using molecular dynamics.

  10. International Standards for Radiation Sterilization of Medical Devices

    International Nuclear Information System (INIS)

    For a terminally sterilized medical device to be designated '' STERILE '', probability of finding the viable micro-organisms in the device shall be equal to or less than 1 x 10-6 (EN 556-1:2001: Sterilization of medical devices - Requirements for medical devices to be designated '' STERILE '' - Part 1: Requirements for terminally sterilized medical devices). Author presents the main legal aspects of the international standards for radiation sterilization of medical devices

  11. In-flight Medical Emergencies

    Directory of Open Access Journals (Sweden)

    Amit Chandra

    2013-09-01

    Full Text Available Introduction: Research and data regarding in-flight medical emergencies during commercial air travel are lacking. Although volunteer medical professionals are often called upon to assist, there are no guidelines or best practices to guide their actions. This paper reviews the literature quantifying and categorizing in-flight medical incidents, discusses the unique challenges posed by the in-flight environment, evaluates the legal aspects of volunteering to provide care, and suggests an approach to managing specific conditions at 30,000 feet.Methods: We conducted a MEDLINE search using search terms relevant to aviation medical emergencies and flight physiology. The reference lists of selected articles were reviewed to identify additional studies.Results: While incidence studies were limited by data availability, syncope, gastrointestinal upset, and respiratory complaints were among the most common medical events reported. Chest pain and cardiovascular events were commonly associated with flight diversion.Conclusion: When in-flight medical emergencies occur, volunteer physicians should have knowledge about the most common in-flight medical incidents, know what is available in on-board emergency medical kits, coordinate their therapy with the flight crew and remote resources, and provide care within their scope of practice. [West J Emerg Med. 2013;14(5:499–504.

  12. Carbohydrate-enriched cyanobacterial biomass as feedstock for bio-methane production through anaerobic digestion

    DEFF Research Database (Denmark)

    Markou, Giorgos; Angelidaki, Irini; Georgakakis, Dimitris

    2013-01-01

    ) were used. The overall observation as the biomass carbohydrates increased was that bio-methane yield increased. The highest bio-methane yield in bioreactors with 60% carbohydrates was 203±10ml CH4 gCODinfl-1, while the lowest bio-methane yield in bioreactors with 20% carbohydrates was 123±10ml CH4 g......CODinfl-1. The trend of increasing bio-methane yield as carbohydrates content of the biomass increased was observed almost in all three HRT (15, 20 and 30days) studied and after thermal pre-treatment. However, thermal pre-treatment did not improve the bio-methane yield. Ammonia concentration had an overall...... trend to decrease as the biomass carbohydrates content increased. This study concludes that the increase of biomass carbohydrates through phosphorus limitation process is an attractive technique to improve the bio-methane yield....

  13. Food choices, perceptions of healthiness, and eating motives of self-identified followers of a low-carbohydrate diet

    Directory of Open Access Journals (Sweden)

    Piia Jallinoja

    2014-12-01

    Full Text Available Background: Low-carbohydrate (LC diets have gained substantial media coverage in many Western countries. Little is, however, known about the characteristics of their followers. Objective: The article analyses how those who report following an LC diet differ from the rest of the population in their background, food choices, weight reduction status, as well as food-related perceptions and motives. The data are a part of the Health Behaviour and Health among the Finnish Adult Population survey collected in spring 2012 (n=2,601, covering 15- to 64-year-old Finns. Results: Seven per cent of the respondents identified themselves as followers of the LC diet. Gender and education were not associated with following an LC diet. The youngest respondents were the least likely to follow such a diet. The LC diet group preferred butter but also vegetables more commonly than the other respondents and were less likely to use vegetable bread spreads. The followers of the LC diet and the other respondents agreed about the healthiness of whole grain, vegetable oils, vegetables, and fruits and berries, and of the harmfulness of white wheat. Compared to the other respondents, the LC diet group was less likely to regard eating vegetable/low-fat products as important, more likely to regard eating healthy carbohydrates, and the health and weight-managing aspects of foods, as important and placed less value on sociability and pleasures connected to food. The results showed varying food choices among the followers of the LC diet: some even reported that they were not avoiding carbohydrates, sugars, and white wheat in their diet. Conclusions: Planners of nutrition policies should follow-up on new diets as they emerge and explore the food choices and motives of their followers and how these diets affect the food choices of the whole population.

  14. Food choices, perceptions of healthiness, and eating motives of self-identified followers of a low-carbohydrate diet

    Science.gov (United States)

    Jallinoja, Piia; Niva, Mari; Helakorpi, Satu; Kahma, Nina

    2014-01-01

    Background Low-carbohydrate (LC) diets have gained substantial media coverage in many Western countries. Little is, however, known about the characteristics of their followers. Objective The article analyses how those who report following an LC diet differ from the rest of the population in their background, food choices, weight reduction status, as well as food-related perceptions and motives. The data are a part of the Health Behaviour and Health among the Finnish Adult Population survey collected in spring 2012 (n=2,601), covering 15- to 64-year-old Finns. Results Seven per cent of the respondents identified themselves as followers of the LC diet. Gender and education were not associated with following an LC diet. The youngest respondents were the least likely to follow such a diet. The LC diet group preferred butter but also vegetables more commonly than the other respondents and were less likely to use vegetable bread spreads. The followers of the LC diet and the other respondents agreed about the healthiness of whole grain, vegetable oils, vegetables, and fruits and berries, and of the harmfulness of white wheat. Compared to the other respondents, the LC diet group was less likely to regard eating vegetable/low-fat products as important, more likely to regard eating healthy carbohydrates, and the health and weight-managing aspects of foods, as important and placed less value on sociability and pleasures connected to food. The results showed varying food choices among the followers of the LC diet: some even reported that they were not avoiding carbohydrates, sugars, and white wheat in their diet. Conclusions Planners of nutrition policies should follow-up on new diets as they emerge and explore the food choices and motives of their followers and how these diets affect the food choices of the whole population. PMID:25490960

  15. Medical Information & Technology: Rapidly Expanding Vast Horizons

    Science.gov (United States)

    Sahni, Anil K.

    2012-12-01

    During ÑMedical Council Of India?, Platinum Jubilee Year (1933-2008) Celebrations, In Year 2008, Several Scientific Meeting/Seminar/Symposium, On Various Topics Of Contemporary Importance And Relevance In The Field Of ÑMedical Education And Ethics?, Were Organized, By Different Medical Colleges At Various Local, State, National Levels. The Present Discussion, Is An Comprehensive Summary Of Various Different Aspects of ìMedical Information Communication Technologyî, Especially UseFul For The Audience Stratum Group Of Those Amateur Medical & Paramedical Staff, With No Previous Work Experience Knowledge Of Computronics Applications. Outlining The, i.Administration Applications: Medical Records Etc, ii. Clinical Applications: Pros pective Scope Of TeleMedicine Applicabilities Etc iii. Other Applications: Efforts To Augment Improvement Of Medical Education, Medical Presentations, Medical Education And Research Etc. ÑMedical Trancription? & Related Recent Study Fields e.g ÑModern Pharmaceuticals?,ÑBio-Engineering?, ÑBio-Mechanics?, ÑBio-Technology? Etc., Along With Important Aspects Of Computers-General Considerations, Computer Ergonomics Assembled To Summarize, The AwareNess Regarding Basic Fundamentals Of Medical Computronics & Its Practically SuccessFul Utilities.

  16. Medical leasing.

    Science.gov (United States)

    Holden, Elizabeth A

    2012-01-01

    Leases for medical space can have far-reaching (and sometimes unintentional) consequences for the future of the practice and the costs of the business. In order to prevent hardship and expense down the line, it is especially important to review the lease to make sure that it reflects the practice's goals, needs, and structure. This article provides a number of provisions that are especially crucial to review and negotiate when leasing medical space, including use restrictions, assignment and subleasing clauses, build-out terms, and legal compliance requirements. PMID:22594070

  17. Medical Applications

    CERN Document Server

    Biscari, C

    2014-01-01

    The use of accelerators for medical applications has evolved from initial experimentation to turn-key devices commonly operating in hospitals. New applications are continuously being developed around the world, and the hadrontherapy facilities of the newest generation are placed at the frontier between industrial production and advanced R&D. An introduction to the different medical application accelerators is followed by a description of the hadrontherapy facilities, with special emphasis on CNAO, and the report closes with a brief outlook on the future of this field.

  18. Psychological aspects of asthma.

    Science.gov (United States)

    Lehrer, Paul; Feldman, Jonathan; Giardino, Nicholas; Song, Hye-Sue; Schmaling, Karen

    2002-06-01

    Asthma can be affected by stress, anxiety, sadness, and suggestion, as well as by environmental irritants or allergens, exercise, and infection. It also is associated with an elevated prevalence of anxiety and depressive disorders. Asthma and these psychological states and traits may mutually potentiate each other through direct psychophysiological mediation, nonadherence to medical regimen, exposure to asthma triggers, and inaccuracy of asthma symptom perception. Defensiveness is associated with inaccurate perception of airway resistance and stress-related bronchoconstriction. Asthma education programs that teach about the nature of the disease, medications, and trigger avoidance tend to reduce asthma morbidity. Other promising psychological interventions as adjuncts to medical treatment include training in symptom perception, stress management, hypnosis, yoga, and several biofeedback procedures. PMID:12090377

  19. Production of Single-Chain Variable-Fragments against Carbohydrate Antigens

    OpenAIRE

    Yoko Fujita-Yamaguchi

    2014-01-01

    The production of human single-chain variable-fragments (scFvs) against carbohydrate antigens by phage display technology is seemingly a logical strategy towards the development of antibody therapeutics, since carbohydrates are self-antigens. Panning and screening of phages displaying human scFvs using a variety of neoglycolipids presenting structurally-defined carbohydrates resulted in a number of candidate phage clones as judged by cautious evaluation of DNA sequences and specific binding t...

  20. Effects of fatty acids on carbohydrates and lipids of canola seeds during germination

    OpenAIRE

    M.L.L. Ferrarese; C. R. S. Baleroni; O. Ferrarese-Filho

    1998-01-01

    The present work was carried out to investigate the effects of caprylic acid (C8) and oleic acid (C18) on carbohydrates and lipids during canola seed germination. The results showed that oleic acid influence carbohydrate concentration but did not influence lipid concentration. Significant results were found with caprylic acid that affected carbohydrates and lipids in cotyledons after three-day germination.O presente trabalho foi realizado com o objetivo de investigar os efeitos dos ácidos cap...

  1. DOCIS :a Model to Simulate Carbohydrate Balance and Development of Inflorescence during Vase Life

    OpenAIRE

    Meeteren, van, U.; Peppel, van de, J.; Gelder, van, R.E.

    2001-01-01

    The concept of a dynamic and deterministic model (DOCIS) was developed to simulate post harvest development of an inflorescence during vase life based on carbohydrate content at harvest. The model was partly parameterized using lily ‘Enchantment’. The inflorescence as a system was defined by the state variables: the carbohydrate pool, structural biomass and development stage of each floret in the inflorescence and the carbohydrate pool in the stem. An additional auxiliary state variable was u...

  2. Method Optimization for Rapid Measurement of Carbohydrates in Plasma by Liquid Chromatography Tandem Mass Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Ductoan; Yu, Jondong; Mho, Sunil; Lee, Gwang [Ajou Univ., Suwon (Korea, Republic of); Lee, Haelee; Paik, Manjeong [Sangdosijang Pharmacy, Seoul (Korea, Republic of); Yee, Sungtae [Sunchon National Univ., Suncheon (Korea, Republic of)

    2013-05-15

    In conclusion, the developed HPLC coupled with ESI-MS was a powerful technique for the separation and characterization of carbohydrates by either SIM or MRM mode. The present method will be useful for the monitoring of carbohydrate profile in biological fluids from various diseases including diabetic ketoacidosis, hypoglycemia and hyperosmolar coma. Carbohydrates are one of the most abundant classes of organic compounds in nature, which not only constitute complex biomolecules in human and animals but are also distributed in plants and bacteria.

  3. Biofuel Production Based on Carbohydrates from Both Brown and Red Macroalgae: Recent Developments in Key Biotechnologies

    OpenAIRE

    Shigeyuki Kawai; Kousaku Murata

    2016-01-01

    Marine macroalgae (green, red and brown macroalgae) have attracted attention as an alternative source of renewable biomass for producing both fuels and chemicals due to their high content of suitable carbohydrates and to their advantages over terrestrial biomass. However, except for green macroalgae, which contain relatively easily-fermentable glucans as their major carbohydrates, practical utilization of red and brown macroalgae has been regarded as difficult due to the major carbohydrates (...

  4. Medical Ethics

    Science.gov (United States)

    ... have an ethical aspect. For example, there are ethical issues relating to End of life care: Should a patient receive nutrition? What about advance directives and resuscitation orders? Abortion: When does life begin? Is it ethical to terminate a pregnancy with a birth defect? ...

  5. Alteration of the carbohydrate-binding specificity of a C-type lectin CEL-I mutant with an EPN carbohydrate-binding motif.

    Science.gov (United States)

    Hatakeyama, Tomomitsu; Ishimine, Tomohiro; Baba, Tomohiro; Kimura, Masanari; Unno, Hideaki; Goda, Shuichiro

    2013-07-01

    CEL-I is a Gal/GalNAc-specific C-type lectin isolated from the sea cucumber Cucumaria echinata. This lectin is composed of two carbohydrate-recognition domains (CRDs) with the carbohydrate-recognition motif QPD (Gln-Pro- Asp), which is generally known to exist in galactose-specific C-type CRDs. In the present study, a mutant CEL-I with EPN (Glu-Pro-Asn) motif, which is thought to be responsible for the carbohydrate-recognition of mannose-specific Ctype CRDs, was produced in Escherichia coli, and its effects on the carbohydrate-binding specificity were examined using polyamidoamine dendrimer (PD) conjugated with carbohydrates. Although wild-type CEL-I effectively formed complexes with N-acetylgalactosamine (GalNAc)-PD but not with mannose-PD, the mutant CEL-I showed relatively weak but definite affinity for mannose-PD. These results indicated that the QPD and EPN motifs play a significant role in the carbohydrate-recognition mechanism of CEL-I, especially in the discrimination of galactose and mannose. Additional mutations in the recombinant CEL-I binding site may further increase its specificity for mannose, and should provide insights into designing novel carbohydrate-recognition proteins. PMID:23157284

  6. Radiation physics for medical physicists

    International Nuclear Information System (INIS)

    This book summarizes the radiation physics knowledge that professionals working in medical physics need to master for efficient and safe dealings with ionizing radiation. It contains eight chapters, each chapter covering a specific group of subjects related to radiation physics and is intended as a textbook for a course in radiation physics in medical-physics graduate programs. However, the book may also be of interest to the large number of professionals, not only medical physicists, who in their daily occupations deal with various aspects of medical physics and find a need to improve their understanding of radiation physics. The main target audience for this book is graduate students studying for M.Sc. and Ph.D. degrees in medical physics, who have to possess the necessary physics and mathematics background knowledge to be able to follow and master the complete textbook. Medical residents, technology students and biomedical engineering students may find certain sections too challenging or esoteric, yet they will find many sections interesting and useful in their studies. Candidates preparing for professional certification exams in any of the medical physics subspecialties should find the material useful, and some of the material would also help candidates preparing for certification examinations in medical dosimetry or radiation-related medical specialties. Numerous textbooks are available covering the various subspecialties of medical physics but they generally make a transition from the elementary basic physics directly into the intricacies of the given medical physics subspecialty. The intent of this textbook is to provide the missing link between the elementary physics on the one hand and the physics of the subspecialties on the other hand. (orig.)

  7. Botany in Edinburgh's Medical Curriculum.

    Science.gov (United States)

    Wilson, Hazel

    2012-01-01

    In the early 18th century, at the founding of Edinburgh University Medical School, the study of botany was regarded as an essential component of medical training. Botanical teaching began as basic instruction in the recognition of medical plants, considered a vital aspect of a physician's Materia Medica studies. Over the next hundred years growing importance was given to the study of botany as a science, its popularity peaking under John Hutton Balfour's tenure as Professor (1845-1879). The relevance of botanical study later declined in the undergraduate medical curriculum until its cessation in 1961 .This paper considers the history of botanical studies in Edinburgh, including the reasons for its introduction and its changing importance over time. PMID:26591068

  8. Aspects of Marine Ecology.

    Science.gov (United States)

    Awkerman, Gary L.

    This publication is designed for use in standard science curricula to develop oceanologic manifestations of certain science topics. Included are teacher guides, student activities, and demonstrations to impart ocean science understanding, specifically, aspects of marine ecology, to high school students. The course objectives include the ability of…

  9. Toxicological aspects of water

    International Nuclear Information System (INIS)

    Different toxicological aspects of water have been studied, remarking the activity of various chemical substances in the organism. These substances are divided in: trace metals (Sb, As, Cd, Zn, Cu, Cr, Fe, Mn, Hg, Ni, Pb, Se), other contaminants (CN-, polycyclic aromatic hydrocarbons, phenols, pesticides, detergents) and radioactivity. Finally, some considerations on this subject are made

  10. Psychological Aspects of Aging.

    Science.gov (United States)

    Mooney, Craig M.

    1980-01-01

    Psychological aspects of aging, based on gerontological hypotheses and research, are presented under three headings: intellectual abilities; emotional capacities; and motor capabilities. Consequences are discussed. Well-being throughout life depends on fulfillment of fundamental human needs; existential needs for nourishment, stimulation, rest,…

  11. Quantum Chromodynamics: Computational Aspects

    CERN Document Server

    Schaefer, Thomas

    2016-01-01

    We present a brief introduction to QCD, the QCD phase diagram, and non-equilibrium phenomena in QCD. We emphasize aspects of the theory that can be addressed using computational methods, in particular euclidean path integral Monte Carlo, fluid dynamics, kinetic theory, classical field theory and holographic duality.

  12. Gout. Radiological aspects

    International Nuclear Information System (INIS)

    In this paper we reviewed the clinical and radiological aspects of gout, showing the most frequent radiological findings that can guide to the correct diagnosis of the disease. The cases that we presented here have been analyzed for many years in our rheumatology service, Universidad Nacional de Colombia, Hospital San Juan de Dios, Bogota

  13. Glaucoma medications.

    Science.gov (United States)

    Chae, Bora; Cakiner-Egilmez, Tulay; Desai, Manishi

    2013-01-01

    Glaucoma is a common eye condition that affects millions of individuals worldwide, making it the second-leading cause of blindness. Because glaucoma is associated with increased IOP level, the primary goal in treatment of glaucoma includes lowering IOP to prevent further progression of the disease. While various surgical interventions exist, medical therapy is currently the first line of treatment. Medical treatment of glaucoma includes topical beta-blockers, alpha-2 agonists, prostaglandins, parasympathomimetics and CAIs. Anti-glaucoma agents help reduce IOP by affecting the production of aqueous humor or increasing the outflow of aqueous through the trabecular or uveoscleral pathway. Choosing an appropriate medical regimen can be challenging and various factors such as efficacy, safety, cost and patient compliance must be considered. First-line treatment is often topical beta-blockers or prostaglandin analogs. However, beta-blocking agents can be associated with systemic side effects and need to be used cautiously in patients with serious concomitant cardiopulmonary disease. Alpha-2 agonists and parasympathomimetics are often considered second- or third-line treatment options but good adjunctive agents. Oral CAIs are often indicated for patients with elevated IOP in an acute setting or for patients resistant to other glaucoma medications and patients who are not good surgical candidates. PMID:23505792

  14. Medication Errors

    Science.gov (United States)

    ... Proprietary Names (PDF - 146KB) Draft Guidance for Industry: Best Practices in Developing Proprietary Names for Drugs (PDF - 279KB) ... or (301) 796-3400 druginfo@fda.hhs.gov Human Drug ... in Medication Errors Resources for You Agency for Healthcare Research and Quality: ...

  15. The Effects of Marine Carbohydrates and Glycosylated Compounds on Human Health

    Directory of Open Access Journals (Sweden)

    Hee-Kyoung Kang

    2015-03-01

    Full Text Available Marine organisms have been recognized as a valuable source of bioactive compounds with industrial and nutraceutical potential. Recently, marine-derived carbohydrates, including polysaccharides and low molecular weight glycosylated oligosaccharides, have attracted much attention because of their numerous health benefits. Moreover, several studies have reported that marine carbohydrates exhibit various biological activities, including antioxidant, anti-infection, anticoagulant, anti-inflammatory, and anti-diabetic effects. The present review discusses the potential industrial applications of bioactive marine carbohydrates for health maintenance and disease prevention. Furthermore, the use of marine carbohydrates in food, cosmetics, agriculture, and environmental protection is discussed.

  16. Seasonal carbohydrate storage and mobilization in bearing and non-bearing pistachio (Pistacia vera) trees.

    Science.gov (United States)

    Spann, Timothy M; Beede, Robert H; Dejong, Theodore M

    2008-02-01

    We analyzed annual carbohydrate storage and mobilization of bearing ("on") and non-bearing ("off") 'Kerman' pistachio (Pistacia vera L.) trees growing on three different rootstocks. On all rootstocks, carbohydrate storage in shoots and branches of "on" and "off" trees was lowest following the spring growth flush. In "off" trees, stored carbohydrates increased and remained high after the initial growth flush. In "on" trees, stem carbohydrates increased temporarily in early summer, but were mobilized in mid-season during kernel fill, and then increased again after nut harvest. During the dormant season, the only substantial differences in carbohydrate storage between previously "on" and "off" trees were found in the roots of the weakest rootstock. The annual carbohydrate storage and mobilization pattern in canopy branches of heavily cropped pistachio trees appeared to be driven by carbohydrate demands related to nut development and untempered by tree vigor. Mobilization of carbohydrates from current-season and 1- and 2-year-old stem wood of "on" trees during the primary period of kernel fill corresponded with the period of inflorescence bud abscission. Thus, the alternate bearing pattern associated with inflorescence bud abscission in 'Kerman' pistachio may be a function of mid-season mobilization of stored carbohydrates in current-season stems resulting in stimulation of inflorescence bud abscission. PMID:18055431

  17. Entirely Carbohydrate-Based Vaccines: An Emerging Field for Specific and Selective Immune Responses

    Science.gov (United States)

    Nishat, Sharmeen; Andreana, Peter R.

    2016-01-01

    Carbohydrates are regarded as promising targets for vaccine development against infectious disease because cell surface glycans on many infectious agents are attributed to playing an important role in pathogenesis. In addition, oncogenic transformation of normal cells, in many cases, is associated with aberrant glycosylation of the cell surface glycan generating tumor associated carbohydrate antigens (TACAs). Technological advances in glycobiology have added a new dimension to immunotherapy when considering carbohydrates as key targets in developing safe and effective vaccines to combat cancer, bacterial infections, viral infections, etc. Many consider effective vaccines induce T-cell dependent immunity with satisfactory levels of immunological memory that preclude recurrence. Unfortunately, carbohydrates alone are poorly immunogenic as they do not bind strongly to the MHCII complex and thus fail to elicit T-cell immunity. To increase immunogenicity, carbohydrates have been conjugated to carrier proteins, which sometimes can impede carbohydrate specific immunity as peptide-based immune responses can negate antibodies directed at the targeted carbohydrate antigens. To overcome many challenges in using carbohydrate-based vaccine design and development approaches targeting cancer and other diseases, zwitterionic polysaccharides (ZPSs), isolated from the capsule of commensal anaerobic bacteria, will be discussed as promising carriers of carbohydrate antigens to achieve desired immunological responses. PMID:27213458

  18. Prepregnancy low-carbohydrate dietary pattern and risk of gestational diabetes mellitus: a prospective cohort study

    DEFF Research Database (Denmark)

    Bao, Wei; Bowers, Katherine; Tobias, Deirdre K;

    2014-01-01

    BACKGROUND: Low-carbohydrate diets (LCDs) have been vastly popular for weight loss. The association between a low-carbohydrate dietary pattern and risk of gestational diabetes mellitus (GDM) remains unknown. OBJECTIVE: We aimed to prospectively examine the association of 3 prepregnancy low...... age, parity, family history of diabetes, physical activity, or overweight status. CONCLUSIONS: A prepregnancy low-carbohydrate dietary pattern with high protein and fat from animal-food sources is positively associated with GDM risk, whereas a prepregnancy low-carbohydrate dietary pattern with high...

  19. Entirely Carbohydrate-Based Vaccines: An Emerging Field for Specific and Selective Immune Responses.

    Science.gov (United States)

    Nishat, Sharmeen; Andreana, Peter R

    2016-01-01

    Carbohydrates are regarded as promising targets for vaccine development against infectious disease because cell surface glycans on many infectious agents are attributed to playing an important role in pathogenesis. In addition, oncogenic transformation of normal cells, in many cases, is associated with aberrant glycosylation of the cell surface glycan generating tumor associated carbohydrate antigens (TACAs). Technological advances in glycobiology have added a new dimension to immunotherapy when considering carbohydrates as key targets in developing safe and effective vaccines to combat cancer, bacterial infections, viral infections, etc. Many consider effective vaccines induce T-cell dependent immunity with satisfactory levels of immunological memory that preclude recurrence. Unfortunately, carbohydrates alone are poorly immunogenic as they do not bind strongly to the MHCII complex and thus fail to elicit T-cell immunity. To increase immunogenicity, carbohydrates have been conjugated to carrier proteins, which sometimes can impede carbohydrate specific immunity as peptide-based immune responses can negate antibodies directed at the targeted carbohydrate antigens. To overcome many challenges in using carbohydrate-based vaccine design and development approaches targeting cancer and other diseases, zwitterionic polysaccharides (ZPSs), isolated from the capsule of commensal anaerobic bacteria, will be discussed as promising carriers of carbohydrate antigens to achieve desired immunological responses. PMID:27213458

  20. THE IMPORTANCE OF DIETARY CARBOHYDRATE IN HUMAN EVOLUTION.

    Science.gov (United States)

    Hardy, Karen; Brand-Miller, Jennie; Brown, Katherine D; Thomas, Mark G; Copeland, Les

    2015-09-01

    ABSTRACT We propose that plant foods containing high quantities of starch were essential for the evolution of the human phenotype during the Pleistocene. Although previous studies have highlighted a stone tool-mediated shift from primarily plant-based to primarily meat-based diets as critical in the development of the brain and other human traits, we argue that digestible carbohydrates were also necessary to accommodate the increased metabolic demands of a growing brain. Furthermore, we acknowledge the adaptive role cooking played in improving the digestibility and palatability of key carbohydrates. We provide evidence that cooked starch, a source of preformed glucose, greatly increased energy availability to human tissues with high glucose demands, such as the brain, red blood cells, and the developing fetus. We also highlight the auxiliary role copy number variation in the salivary amylase genes may have played in increasing the importance of starch in human evolution following the origins of cooking. Salivary amylases are largely ineffective on raw crystalline starch, but cooking substantially increases both their energy-yielding potential and glycemia. Although uncertainties remain regarding the antiquity of cooking and the origins of salivary amylase gene copy number variation, the hypothesis we present makes a testable prediction that these events are correlated. PMID:26591850