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Sample records for capillary leak syndrome

  1. Systemic Capillary Leak Syndrome associated with hypovolemic shock and compartment syndrome. Use of transpulmonary thermodilution technique for volume management

    Directory of Open Access Journals (Sweden)

    Schmid Roland M

    2010-07-01

    Full Text Available Abstract Systemic Capillary Leak Syndrome (SCLS is a rare disorder characterized by increased capillary hyperpermeability leading to hypovolemic shock due to a markedly increased shift of fluid and protein from the intravascular to the interstitial space. Hemoconcentration, hypoalbuminemia and a monoclonal gammopathy are characteristic laboratory findings. Here we present a patient who suffered from SCLS with hypovolemic shock and compartment syndrome of both lower legs and thighs. Volume and catecholamine management was guided using transpulmonary thermodilution. Extended hemodynamic monitoring for volume and catecholamine management as well as monitoring of muscle compartment pressure is of crucial importance in SCLS patients.

  2. Clofarabine associated capillary leak syndrome in a child with lymphoma successfully treated with intravenous immunoglobulin.

    Science.gov (United States)

    Kesik, Vural; Atas, Erman; Korkmazer, Nadir; Babacan, Oguzhan

    2015-01-01

    Clofarabine is an effective drug in relapsed leukemia and lymphoma that has some adverse effects which can be fatal like capillary leak syndrome (CLS). Identification and management of CLS is important that may result in mortality. Although prophylactic treatment with steroids may prevent CLS and improve survival, intravenous immunoglobulins are used in the treatment with great success in steroid resistant cases. However, the knowledge about the effects and the dose of intravenous immunoglobulins (IVIG) in pediatric patients is limited. Herein, we reported a patient with relapsed lymphoma who developed CLS successfully and was treated with IVIG. PMID:26458636

  3. Systemic capillary leak syndrome in a patient receiving adjuvant oxaliplatin for locally advanced colon cancer.

    Science.gov (United States)

    Anderson, Brandon J; Peterson, Lindsay L

    2016-10-01

    Colorectal cancer is the third most common cancer diagnosed in the USA each year. Oxaliplatin, a platinum-based chemotherapy agent, is part of the standard adjuvant chemotherapy regimen FOLFOX (oxaliplatin with 5-fluorouracil [5-FU] and leucovorin [LV]) for the treatment of stage III and some high-risk stage II colorectal cancers. Although oxaliplatin is generally well tolerated, certain side effects such as nausea, vomiting, and peripheral neuropathy are common. We report a case of oxaliplatin-induced capillary-leak syndrome in a 63-year-old man undergoing his 12th and final cycle of FOLFOX for stage III colorectal cancer. To our knowledge, this is the first case of systemic capillary leak syndrome (SCLS) reported in association with oxaliplatin. Currently, there is no prevention for SCLS. Documenting future cases of SCLS attributed to oxaliplatin is vital, as SCLS is associated with significant morbidity and mortality and no standard treatments beyond supportive care measures exist. Early recognition and diagnosis are therefore essential to improving patient outcomes. PMID:26071595

  4. A Systemic Capillary Leak Syndrome (Clarkson Syndrome) in a Patient with Chronic Lymphocytic Leukemia: A Case Report in an Out-of-Hospital Setting

    OpenAIRE

    Manon Durand Bechu; Antoine Rouget; Christian Recher; Elie Azoulay; Vincent Bounes

    2016-01-01

    Systemic Capillary Leak Syndrome (SCLS) is a rare disease with poor prognosis, characterized by the occurrence of mucocutaneous and visceral edema with hypotension, hemoconcentration, and unexpected hypoalbuminemia. The disease can be idiopathic (Clarkson syndrome) or secondary to other diseases and treatments. We describe this syndrome in a prehospitalized, 63-year-old patient with chronic lymphocytic leukemia and an idiopathic form of SCLS manifesting as hypovolemic shock. Initial care is h...

  5. Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia

    Directory of Open Access Journals (Sweden)

    Li-Rong Shen

    2011-05-01

    Full Text Available Abstract Background Capillary leak syndrome (CLS is a rare condition characterized by recurrent episodes of generalized edema and severe hypotension associated with hypoproteinemia. Interleukin-11 (IL-11 is a promising therapeutic agent for thrombocytopenia. A direct correlation between IL-11 and CLS has never been reported previously, particularly in patients with hepatic carcinoma. Case presentation We describe two cases of CLS after IL-11 administration in two males with thrombocytopenia. Case 1 was a 46-year-old man with recurrence of hepatic carcinoma who was treated with IL-11 (3 mg per day. After four days of therapy, hypotension and hypoproteinemia were detected. The chest X-ray and B ultrasound of the abdomen showed pleural effusion and ascites. IL-11 was then discontinued, fluid resuscitation was performed, and fresh frozen plasma and packed red blood cells were transfused into this patient. The patient had recovered after 19 days of treatment. Case 2 was a 66-year-old man who had undergone radiofrequency ablation (RFA for hepatic carcinoma. He was treated with IL-11 (3 mg per day for thrombocytopenia. After two days of therapy, this patient complained of dyspnea with bilateral edema of the hands. Laboratory values showed hypoproteinemia. IL-11 was stopped and human albumin was transfused at a rate of 10 g per day. On the 4th day, fluid resuscitation was performed. The patient had recovered after treatment for two weeks. Conclusions The detection of IL-11-induced CLS supports the hypothesis that CLS could be a severe side effect of IL-11 treatment in some patients. These two case reports also demonstrate that patients with hepatic carcinoma who experience this rare form of CLS after treatment with IL-11 seem to respond to a therapeutic regimen that involves hydroxyethyl starch, albumin, and diuretic therapy. Liver cancer patients might be more susceptible to CLS because of poor liver function and hypersplenia. In addition, bleeding

  6. A Systemic Capillary Leak Syndrome (Clarkson Syndrome in a Patient with Chronic Lymphocytic Leukemia: A Case Report in an Out-of-Hospital Setting

    Directory of Open Access Journals (Sweden)

    Manon Durand Bechu

    2016-01-01

    Full Text Available Systemic Capillary Leak Syndrome (SCLS is a rare disease with poor prognosis, characterized by the occurrence of mucocutaneous and visceral edema with hypotension, hemoconcentration, and unexpected hypoalbuminemia. The disease can be idiopathic (Clarkson syndrome or secondary to other diseases and treatments. We describe this syndrome in a prehospitalized, 63-year-old patient with chronic lymphocytic leukemia and an idiopathic form of SCLS manifesting as hypovolemic shock. Initial care is hospitalization in intensive care. In addition to etiological treatment if fluid replacement is necessary, treatment must be closely monitored for secondary overload complications. Catecholamine rather than arrhythmogenic support may be associated.

  7. A Systemic Capillary Leak Syndrome (Clarkson Syndrome) in a Patient with Chronic Lymphocytic Leukemia: A Case Report in an Out-of-Hospital Setting

    Science.gov (United States)

    Durand Bechu, Manon; Rouget, Antoine; Recher, Christian; Azoulay, Elie; Bounes, Vincent

    2016-01-01

    Systemic Capillary Leak Syndrome (SCLS) is a rare disease with poor prognosis, characterized by the occurrence of mucocutaneous and visceral edema with hypotension, hemoconcentration, and unexpected hypoalbuminemia. The disease can be idiopathic (Clarkson syndrome) or secondary to other diseases and treatments. We describe this syndrome in a prehospitalized, 63-year-old patient with chronic lymphocytic leukemia and an idiopathic form of SCLS manifesting as hypovolemic shock. Initial care is hospitalization in intensive care. In addition to etiological treatment if fluid replacement is necessary, treatment must be closely monitored for secondary overload complications. Catecholamine rather than arrhythmogenic support may be associated. PMID:27069700

  8. Determinants of diagnostic accuracy in pulmonary scintigraphy for pulmonary capillary protein leak associated with adult respiratory distress syndrome (ARDS): A technical note

    International Nuclear Information System (INIS)

    Radionuclide assessment of pulmonary capillary protein leak using [99mTc] human serum albumin (99mTc-HSA) was first reported from our laboratory. In this study we investigated the impact of 1) sampling time post tracer injection, and 2) lung region assignment, on diagnostic accuracy between 2 groups (control n=20 and ARDS n=20). Each patient received 370 MBq 99mTc-HSA i.v. and was imaged for 45 min. The slope index (SI) [change in lung: Heart activity ratio/min] was calculated from 11 computer assigned lung regions for intervals of 5-15 (early [E] and 15-45 (late [L]) min. The diagnostic accuracy of E vs L SI calculations for the 11 regions was evaluated by stepwise logistic regression. E SI data and L SI data from the lower 1/3 of the lung did not achieve significance for inclusion in the discriminant model (P < 0.05). In the nine remaining regions L SI was significant. Optimal discrimination was achieved from L SI data obtained from a region confined to the lateral half of the mid 3rd of the lung field (sensitivity 81%, specificity 85%, accuracy 83%). The results confirm that: 1) A late (15-45 min) sampling period and 2) proper region assignment are necessary to maximize accuracy of this technique. (orig.)

  9. Effects of oleic acid on pulmonary capillary leak and thromboxanes

    International Nuclear Information System (INIS)

    The role of arachidonic acid metabolites in oleic acid-induced lung injury in anesthetized dogs was investigated. Oleic acid was administered as a bolus injection into the pulmonary artery after either indomethacin (10 mg/kg iv) or vehicle. Measurements of hemodynamic parameters, mean systemic (MAP), pulmonary capillary wedge, and pulmonary artery pressures (PAP), cardiac output, arterial blood gases, extravascular lung waters (EVLW) by thermaldye double indicator dilution techniques and plasma immunoreactive thromboxane B2 (iTxB2), by radioimmunoassay were obtained at zero time (baseline) and 20 min following each oleic acid injection. A new noninvasive technique was employed to measure pulmonary capillary protein leak by the scintigraphic analysis of intravenously administered technetium-99m radiolabeled human serum albumin (99mTc -HSA) in the cardiac and lung regions. Oleic acid injection caused a significant dose related fall in MAP, arterial pO2, and cardiac output, and increases in EVLW and plasma iTxB2 in the vehicle pretreated animals, while mean PAP remained unchanged. In contrast, in the indomethacin pretreated dogs, MAP, EVLW, cardiac output, and plasma iTxB2 levels did not change from baseline values and there was an increase in mean PAP. Pulmonary vascular resistance was significantly elevated in both groups

  10. 影响毛细血管渗漏综合征预后的因素分析%Influence factors on prognosis of the patients with capillary leak syndrome

    Institute of Scientific and Technical Information of China (English)

    苏俊; 王锦权; 陶晓根; 刘宝; 莫宝定; 张霖

    2012-01-01

    Objective To discuss influence factors on prognosis of the patients with capillary leak syndrome (CLS) in ICU.Methods The clinical data of 191 patients with CLS in ICU were reviewed,and the patients were divided into three groups according to prognosis:death group ( n =37),cured group ( n =132) and non-healed group (n =22).The clinical data of death group were compared with those of cured group at admission,during the course of CLS and before discharging from hospital.Results Compared with the cured group,the central venous pressure and serum albumin decreased ( P < 0.01 ) ; anion gap,triglycerides,pressure adjusted heart rate (PAHR) and oxygenation index were lower ( P < 0.01 or P < 0.05) ; serum glucose and SIRS score increased ( P < 0.01 ) in death group.There was higher rate of poor renal function at admission in death group than that in other groups ( P < 0.01 ).There were more many patients treated with intravenous administration of hydroxyethyl starch,ulinastatin and continuous blood filtration therapy in cured group than those in other groups ( P < 0.05).Conclusions The factors influencing the outcomes of the patients with CLS were hypovolemia,severe hypoproteinemia,interior milieu disorder,malnutrition,hypoxemia,renal injury and severe systemic inflammatory response.The outcomes of patients with CLS in ICU could be improved by using hydroxyethyl starch,ulinastatin and continuous blood filtration therapy.%目的 探讨影响毛细血管渗漏综合征(CLS)患者预后的相关因素.方法 对安徽省立医院重症医学科收治的191例出现CLS患者的临床资料进行回顾性分析,按疾病转归将患者分为3组:死亡组37例,治愈组132例,未愈组22例.将治愈组和死亡组患者在入院时、出现CLS时和出院前的各项临床资料进行比较,探寻影响患者预后的相关因素.结果 与治愈组比较,死亡组患者的中心静脉压、血清白蛋白明显降低(P<0.01),阴离子间隙、甘油三酯、压

  11. Microsystem with integrated capillary leak to mass spectrometer for high sensitivity temperature programmed desorption

    DEFF Research Database (Denmark)

    Quaade, Ulrich; Jensen, Søren; Hansen, Ole

    2004-01-01

    Temperature programmed desorption (TPD) is a method for obtaining information about quantities and binding properties of adsorbed species on a surface. A microfabricated flow system for TPD with an integrated capillary leak to a mass spectrometer is presented. The use of an integrated capillary.......5 cm2 of platinum foil gives a clear desorption peak. By using the microfabricated flow system, TPD experiments can be performed in a carrier gas with a sensitivity approaching that of TPD experiments in vacuum. ©2004 American Institute of Physics...

  12. AIR LEAK SYNDROME AND A RARE CASES PRESENTATION OF PNEUMOPERICARDIUM ASSOCIATED WITH AIR EMBOLISM IN TTN BABY

    Directory of Open Access Journals (Sweden)

    Dinakara

    2014-04-01

    Full Text Available : Air leak syndromes are a group of clinically recognizable disorders produced by alveolar rupture and subsequent escape of air in to the tissue in which air is not normally present. All the clinical types of air leak syndrome originate in over distended alveoli, which ultimately rupture. Over distention is because of spontaneous vigorous respirations (usually larger term babies at birth, increased pressure of mechanical ventilator (PEEP, PIP vigorous Cardio Pulmonary resuscitation, air trapping in the presence of a ball valve mechanism, most of this air leaks occur spontaneously, but incidence increases with ventilator support, in some cases of collagen vascular diseases and associated renal problems.1 But in our study spontaneous pneumopericardium with air embolism a rare presentation and spontaneously recovered and followed up to one year. Timely radiological investigations including x-rays, USG chest, and ultra sound guided drainage of pneumopericardium with help of radiologist, play an important role in the management preventing morbidity and mortality.

  13. Tetralogy of Fallot associated with macrocephaly-capillary malformation syndrome: a case report and review of the literature

    OpenAIRE

    Dueñas-Arias Jesus E; Arámbula-Meraz Eliakym; Frías-Castro Luis O; Ramos-Payán Rosalio; Quibrera-Matienzo Jose A; Luque-Ortega Fred; Aguilar-Medina E Maribel

    2009-01-01

    Abstract Introduction Macrocephaly-capillary malformation syndrome is characterized by cutaneous vascular lesions, including cutis marmorata telangiectatica and hemangiomas, associated with congenital anomalies, including macrocephaly, macrosomia, asymmetry and mental retardation. In addition to these cardinal signs, several other clinical conditions have been reported in people with this condition. However, to the best of our knowledge, the presence of tetralogy of Fallot has not previously ...

  14. RASA1 somatic mutation and variable expressivity in capillary malformation/arteriovenous malformation (CM/AVM) syndrome.

    Science.gov (United States)

    Macmurdo, Colleen F; Wooderchak-Donahue, Whitney; Bayrak-Toydemir, Pinar; Le, Jenny; Wallenstein, Matthew B; Milla, Carlos; Teng, Joyce M C; Bernstein, Jonathan A; Stevenson, David A

    2016-06-01

    Germline mutations in RASA1 are associated with capillary malformation-arteriovenous malformation (CM-AVM) syndrome. CM-AVM syndrome is characterized by multi-focal capillary malformations and arteriovenous malformations. Lymphatic anomalies have been proposed as part of the phenotype. Intrafamilial variability has been reported, suggesting modifiers and somatic events. The objective of the study was to identify somatic RASA1 "second hits" from vascular malformations associated with CM-AVM syndrome, and describe phenotypic variability. Participants were examined and phenotyped. Genomic DNA was extracted from peripheral blood on all participants. Whole-exome sequencing was performed on the proband. Using Sanger sequencing, RASA1 exon 8 was PCR-amplified to track the c.1248T>G, p.Tyr416X germline variant through the family. A skin biopsy of a capillary malformation from the proband's mother was also obtained, and next-generation sequencing was performed on DNA from the affected tissue. A familial germline heterozygous novel pathogenic RASA1 variant, c.1248T>G (p.Tyr416X), was identified in the proband and her mother. The proband had capillary malformations, chylothorax, lymphedema, and overgrowth, while her affected mother had only isolated capillary malformations. Sequence analysis of DNA extracted from a skin biopsy of a capillary malformation of the affected mother showed a second RASA1 somatic mutation (c.2245C>T, p.Arg749X). These results and the extreme variable expressivity support the hypothesis that somatic "second hits" are required for the development of vascular anomalies associated with CM-AVM syndrome. In addition, the phenotypes of the affected individuals further clarify that lymphatic manifestations are also part of the phenotypic spectrum of RASA1-related disorders. © 2016 Wiley Periodicals, Inc. PMID:26969842

  15. Increased pulmonary alveolar-capillary permeability in patients at risk for adult respiratory distress syndrome

    International Nuclear Information System (INIS)

    Two methods for predicting adult respiratory distress syndrome (ARDS) were evaluated prospectively in a group of 81 multitrauma and sepsis patients considered at clinical high risk. A popular ARDS risk-scoring method, employing discriminant analysis equations (weighted risk criteria and oxygenation characteristics), yielded a predictive accuracy of 59% and a false-negative rate of 22%. Pulmonary alveolar-capillary permeability (PACP) was determined with a radioaerosol lung-scan technique in 23 of these 81 patients, representing a statistically similar subgroup. Lung scanning achieved a predictive accuracy of 71% (after excluding patients with unilateral pulmonary contusion) and gave no false-negatives. We propose a combination of clinical risk identification and functional determination of PACP to assess a patient's risk of developing ARDS

  16. New trends in leak testing

    International Nuclear Information System (INIS)

    Provisions must be taken in leak tests to prevent the leak capillaries from temporary or apparent clogging that otherwise would distort the results. A heating method was examined for leaks of various size to open on the action of heat. Artificial leaks were produced and tested in gradual heating. A facility was manufactured for providing the heating in practice; this facility is widely applicable to the testing of diverse components. The central element is a universal heating controller. The design of the heating channels makes for application of the facility to a variety of components of different size. (M.D.). 1 tab

  17. Tetralogy of Fallot associated with macrocephaly-capillary malformation syndrome: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Dueñas-Arias Jesus E

    2009-09-01

    Full Text Available Abstract Introduction Macrocephaly-capillary malformation syndrome is characterized by cutaneous vascular lesions, including cutis marmorata telangiectatica and hemangiomas, associated with congenital anomalies, including macrocephaly, macrosomia, asymmetry and mental retardation. In addition to these cardinal signs, several other clinical conditions have been reported in people with this condition. However, to the best of our knowledge, the presence of tetralogy of Fallot has not previously been reported in association with this syndrome. Case presentation We present a case of a Mexican newborn girl with tetralogy of Fallot associated with macrocephaly-capillary malformation. We discuss the clinical treatment of the patient and its consequences. Conclusion Since physiologic cutis marmorata is a common condition in newborns, the information provided in this report could be helpful in future cases in preventing severe clinical consequences or sudden death in patients with similar symptoms.

  18. Evaluation in mice of the capillary leak syndrome (CLS) mediated by the systemic administration of recombinant interleukin-2 (IL-2)

    International Nuclear Information System (INIS)

    Since a CLS with interstitial pulmonary edema has been the major toxicity of IL-2 administration in humans, the authors studied this CLS in mice by quantitating the IL-2 mediated, tissue extravasation (Ex) of intravenously injected 125I-bovine serum albumin (BSA). Mice received saline (HBSS) or 200,000 U of IL-2 intraperitoneally thrice daily from day 0-6 before tissues were counted. A permeability index (PI) was calculated by dividing the mean counts per minute (CPM) from tissues of treated mice by those from controls. In a representative experiment, increased BSA Ex was noted in the lungs of mice treated with IL-2 when compared with HBSS (6187 +/- 141 and 638 +/- 64 CPM +/- SEM, respectively; p2 < .001; PI = 9.7). Other tissues with increased BSA Ex included the liver, spleen, kidneys and mesenteric lymph nodes (PI = 6.7, 10.0, 6.3, 6.0, respectively). BSA Ex, which did not occur with the excipient control, was dependent upon the dose and the duration of IL-2. Serial lung weights showed dramatic increases in water weight induced by IL-2. Treatment of mice with radiation (500R), cyclophosphamide, or cortisone acetate significantly reduced IL-2 mediated BSA Ex. Thus, IL-2 induced a generalized CLS which is mediated directly or indirectly by cellular mechanisms

  19. Evaluation in mice of the capillary leak syndrome (CLS) mediated by the systemic administration of recombinant interleukin-2 (IL-2)

    Energy Technology Data Exchange (ETDEWEB)

    Ettinghausen, S.E.; Rosenstein, M.; Rosenberg, S.A.

    1986-03-01

    Since a CLS with interstitial pulmonary edema has been the major toxicity of IL-2 administration in humans, the authors studied this CLS in mice by quantitating the IL-2 mediated, tissue extravasation (Ex) of intravenously injected /sup 125/I-bovine serum albumin (BSA). Mice received saline (HBSS) or 200,000 U of IL-2 intraperitoneally thrice daily from day 0-6 before tissues were counted. A permeability index (PI) was calculated by dividing the mean counts per minute (CPM) from tissues of treated mice by those from controls. In a representative experiment, increased BSA Ex was noted in the lungs of mice treated with IL-2 when compared with HBSS (6187 +/- 141 and 638 +/- 64 CPM +/- SEM, respectively; p2 < .001; PI = 9.7). Other tissues with increased BSA Ex included the liver, spleen, kidneys and mesenteric lymph nodes (PI = 6.7, 10.0, 6.3, 6.0, respectively). BSA Ex, which did not occur with the excipient control, was dependent upon the dose and the duration of IL-2. Serial lung weights showed dramatic increases in water weight induced by IL-2. Treatment of mice with radiation (500R), cyclophosphamide, or cortisone acetate significantly reduced IL-2 mediated BSA Ex. Thus, IL-2 induced a generalized CLS which is mediated directly or indirectly by cellular mechanisms.

  20. Study on water leak-tightness of small leaks on a 1 inch cylinder valve

    International Nuclear Information System (INIS)

    Practical thresholds for water leak-tightness of small leaks were determined by experimentation. Measurements for small leak samples were taken of air leakage rates and water leakage rates for identical leak samples in order to identify parameters that influence water leak-tightness threshold. Four types of leaks were evaluated: a fine wire inserted in an O-ring seal, a glass capillary tube, a stainless steel orifice, and a scratched valve stem on a 1 inch UF6 cylinder valve. Experimental results demonstrated that the key parameter for water leak-tightness is the opening size of the leak hole. The maximum allowable hole size to achieve water leak-tightness ranged from 10 to 20 μm in diameter in this study. Experimental results with 1 inch UF6 cylinder valve samples demonstrated that the acceptance criteria for preshipment leakage test, 1x10-3 ref-cm3.s-1, as prescribed in ANSI N14.5 is an appropriate value from the point of view of water leak-tightness for enriched UF6 packages. The mechanism of water leak-tightness is plugging by tiny particles existing in water. The water used in experiments in this study contained far fewer particles than in water assumed to be encountered under accident conditions of transport. Therefore, the water leak-tightness threshold determined in this study is a conservative value in a practical evaluation. (author)

  1. Air leaks and vasopressin release.

    OpenAIRE

    McIntosh, N.; Prakash, P.; Smith, A.

    1990-01-01

    Eleven very low birthweight babies being ventilated for respiratory problems during the first week of life developed air leaks on 22 occasions. On 16 out of 19 occasions the infants showed increases in urinary excretion of vasopressin after these events and on 10 occasions out of 13 there was a rise in the plasma arginine vasopressin concentration. The peripheral signs of the syndrome of inappropriate antidiuretic hormone release were seen on only one occasion in response to the sometimes hig...

  2. Amplified leak detection

    Energy Technology Data Exchange (ETDEWEB)

    Mahony, James

    2011-12-15

    Leaks are one of the major concerns for oil and gas producers. But recently, a Calgary-based company developed a tool that can find natural gas leaks in wellbores. This has relieved the oil and gas producers because the optics of finding downhole leaks just got a little brighter. Since then, there have been continuous efforts to broaden and refine fiber optics based methods. This paper presents amplified leak detection using fiber optics to identify even the smallest liquid leaks downhole. At high volumes, detection of downhole leaks in liquids is not a problem but at lower flow rates, the leaks become harder to detect, and at very low flow rates, they might not be detected at all. Hifi Engineering Inc. has developed the LeakSonar fiber optic acoustic sensor array that is specifically designed to detect and locate fluid migration in wellbores, even through multiple strings of casing.

  3. Cytokine-associated angioedema syndromes including episodic angioedema with eosinophilia (Gleich's Syndrome).

    Science.gov (United States)

    Banerji, Aleena; Weller, Peter F; Sheikh, Javed

    2006-11-01

    Angioedema can be associated with many disorders and the presentation can be variable. Subsets of the angioedema syndromes are thought to be cytokine mediated (Table 1). Of these, the best described are the episodic angioedema with eosinophilia syndrome (Gleich's syndrome) and non-episodic angioedema with eosinophilia, which share some common features, but appear to have differences in pathophysiology. NERDS (nodules, eosinophilia, rheumatism, dermatitis and swelling), Clarkson syndrome (idiopathic capillary leak syndrome), and angioedema associated with aldesleukin (human recombinant IL-2) and IFN-alpha have also been reported in the literature, and have been discussed in this review. There is still much to be learned about the pathophysiology, diagnosis, and treatment of patients with these disorders. Our hope is that this review will be of help to those readers who care for patients with these disorders, and will stimulate interest in further research into the pathophysiology of these conditions. PMID:17085290

  4. Innovative techniques in locating eluding micro leaks- case studies

    International Nuclear Information System (INIS)

    The first case study, explains the work experience in the non-destructive testing of tube-to-tube sheet weld joints of sodium heat exchanger of Fast Breeder Test Reactor (FBTR), in locating unacceptable micro leaks by colour contrast penetrant test and maintaining vacuum on shell side to enhance capillary action of penetrant and probing by techniques of isolation and gang probing in leak testing. The other case pertains to experience in locating the micro leak developed in ultra high vacuum, thin film deposition chamber dished end to nozzle weld by application of fluorescent penetrant dye on the exterior of the weld and maintaining vacuum inside the vacuum chamber. (author)

  5. Thyroid dysfunction in Down's syndrome and screening for hypothyroidism in children and adolescents using capillary TSH measurement.

    LENUS (Irish Health Repository)

    Murphy, J

    2008-02-01

    Thyroid dysfunction is more common in individuals with Down\\'s syndrome (DS) than in the general population, whose clinical features can mask the presenting signs and symptoms of hypothyroidism. Biochemical screening is necessary; however, venepuncture may be difficult.

  6. Leak detection/verification

    Energy Technology Data Exchange (ETDEWEB)

    Krhounek, V.; Zdarek, J.; Pecinka, L. [Nuclear Research Institute, Rez (Czech Republic)

    1997-04-01

    Loss of coolant accident (LOCA) experiments performed as part of a Leak Before Break (LBB) analysis are very briefly summarized. The aim of these experiments was to postulate the leak rates of the coolant. Through-wall cracks were introduced into pipes by fatigue cycling and hydraulically loaded in a test device. Measurements included coolant pressure and temperature, quantity of leaked coolant, displacement of a specimen, and acoustic emission. Small cracks were plugged with particles in the coolant during testing. It is believed that plugging will have no effect in cracks with leak rates above 35 liters per minute. The leak rate safety margin of 10 is sufficient for cracks in which the leak rate is more than 5 liters per minute.

  7. Leak detection/verification

    International Nuclear Information System (INIS)

    Loss of coolant accident (LOCA) experiments performed as part of a Leak Before Break (LBB) analysis are very briefly summarized. The aim of these experiments was to postulate the leak rates of the coolant. Through-wall cracks were introduced into pipes by fatigue cycling and hydraulically loaded in a test device. Measurements included coolant pressure and temperature, quantity of leaked coolant, displacement of a specimen, and acoustic emission. Small cracks were plugged with particles in the coolant during testing. It is believed that plugging will have no effect in cracks with leak rates above 35 liters per minute. The leak rate safety margin of 10 is sufficient for cracks in which the leak rate is more than 5 liters per minute

  8. Leaking Chaotic Systems

    CERN Document Server

    Altmann, Eduardo G; Tél, Tamás

    2013-01-01

    There are numerous physical situations in which a hole or leak is introduced in an otherwise closed chaotic system. The leak can have a natural origin, it can mimic measurement devices, and it can also be used to reveal dynamical properties of the closed system. In this paper we provide an unified treatment of leaking systems and we review applications to different physical problems, both in the classical and quantum pictures. Our treatment is based on the transient chaos theory of open systems, which is essential because real leaks have finite size and therefore estimations based on the closed system differ essentially from observations. The field of applications reviewed is very broad, ranging from planetary astronomy and hydrodynamical flows, to plasma physics and quantum fidelity. The theory is expanded and adapted to the case of partial leaks (partial absorption/transmission) with applications to room acoustics and optical microcavities in mind. Simulations in the lima .con family of billiards illustrate...

  9. WRSS jumper leak assessment

    International Nuclear Information System (INIS)

    The purpose of this assessment is: (1) to assemble and document the facts associated with three recently installed jumpers which have leaked either during actual process operation or during post installation testing; (2) to describe the corrective actions taken and to identify any process improvements which need to be implemented in the Hanford jumper design and installation activities; and (3) to document WRSS jumper leak lessons learned for use by future projects and other jumper design, fabrication, and installation activities

  10. Leaking chaotic systems

    Science.gov (United States)

    Altmann, Eduardo G.; Portela, Jefferson S. E.; Tél, Tamás

    2013-04-01

    There are numerous physical situations in which a hole or leak is introduced in an otherwise closed chaotic system. The leak can have a natural origin, it can mimic measurement devices, and it can also be used to reveal dynamical properties of the closed system. A unified treatment of leaking systems is provided and applications to different physical problems, in both the classical and quantum pictures, are reviewed. The treatment is based on the transient chaos theory of open systems, which is essential because real leaks have finite size and therefore estimations based on the closed system differ essentially from observations. The field of applications reviewed is very broad, ranging from planetary astronomy and hydrodynamical flows to plasma physics and quantum fidelity. The theory is expanded and adapted to the case of partial leaks (partial absorption and/or transmission) with applications to room acoustics and optical microcavities in mind. Simulations in the limaçon family of billiards illustrate the main text. Regarding billiard dynamics, it is emphasized that a correct discrete-time representation can be given only in terms of the so-called true-time maps, while traditional Poincaré maps lead to erroneous results. Perron-Frobenius-type operators are generalized so that they describe true-time maps with partial leaks.

  11. Rapidly progressive Bronchiolitis Obliterans Organising Pneumonia presenting with pneumothorax, persistent air leak, acute respiratory distress syndrome and multi-organ dysfunction: a case report

    Directory of Open Access Journals (Sweden)

    Chakravorty Indranil

    2008-05-01

    Full Text Available Abstract Introduction Bronchiolitis Obliterans Organising Pneumonia (BOOP may often present initially as a recurrent spontaneous pneumothorax and then develop multi-system complications. Case presentation A 17-year-old boy presented with a pneumothorax, which developed into rapidly progressive Bronchiolitis Obliterans Organising Pneumonia (BOOP. He developed multi-organ dysfunction (including adult respiratory distress syndrome, oliguric renal failure, acute coronary syndrome, cardiac failure and a right atrial thrombus which necessitated prolonged intensive care. Diagnosis was confirmed on open lung biopsy and he responded well to treatment with corticosteroids. Conclusion BOOP is exquisitely sensitive to oral corticosteroids but if the diagnosis is not considered in such patients and appropriate treatment instituted early, BOOP may often lead to prolonged hospital admission with considerable morbidity.

  12. Leak testing using helium leak detector

    International Nuclear Information System (INIS)

    Most of the equipment used in the industry and particularly in the nuclear activity need to be, vacuum or pressure tight, for operative and safety requirements. These devices have to satisfy particular regulations in order to be qualified by means of operating licences. One of the most efficient system to ensure leaktightnes is using a helium leak detector with a mass spectrometer. In this paper we show the equipment and the devices employed in fuel rods fabrication for CAREM project, and some typical material defects. Operating system and the sensitivity of this method is also described. (author)

  13. Capillary electrophoresis

    International Nuclear Information System (INIS)

    After a short historical introduction, the different modes of separation in capillary electrophoresis are explained and illustrated by practical examples. In addition, the most important parameters that can be used to optimize the selectivity of the separation, are discussed. (author) 27 refs.; 8 figs

  14. Leak-tightness technology

    International Nuclear Information System (INIS)

    In this chapter on the leak-tightness of welded joints a study is made of welding and bonding technology (metals, glass-metals, ceramic-metals), the welding of flanges and collars, the welding of end pieces, the welding of an electric crossover and a bellows

  15. Leaking Fuel Impacts and Practices

    International Nuclear Information System (INIS)

    The impact of leaking fuel rods on the operation of nuclear power plants and the practices of handling leaking fuel has been reviewed by the CSNI Working Group on Fuel Safety in order to promote a better understanding on the handling of leaking fuel in power reactors, as well as to discuss and review the current practices in member countries to help in decisions on the specification of reactor operation conditions with leaking fuel rods and on the handling of leaking fuel after removal from reactor. Experts from 15 countries provided data on the handling of leaking fuel in PWR, BWR, VVER and PHWR reactor types. The review covered the operation of NPP reactors with leaking fuel, wet and dry storage and transport of leaking assemblies. The methods and applied instruments to identify leaking fuel assemblies and the repair of them were addressed in the review. Special attention was paid to the activity release from leaking rods in the reactor and under storage conditions. The consideration of leaking fuel in safety analyses on core behaviour during postulated accidents was also discussed in the review. The main conclusions of the review pointed out that the activity release from leaking fuel rods in the reactor can be handled by technological systems, or in case of failure of too many rods the reactor can be shutdown to minimize activity release. Under accident conditions and operational transients the leaking rods may produce coolant activity concentration peaks. The storage of spent leaking fuel is normally characterised by moderate release of radionuclides from the fuel. The power plants apply limits for activity concentration to limit the amount of leaking rods in the core. In different countries, the accident analyses take into consideration the potential release from leaking fuel rods in design basis accidents in different ways. Some power plants apply special tools for handling and repair of leaking assemblies and rods. The leaking rods are stored together with

  16. Fuel cell leak detector

    International Nuclear Information System (INIS)

    A method and device for leak testing vessels such as fuel cells or tanks which are large enough for a person to move around within holding a small hand held ball or balloon type device which is provided with a large aperture. In leak testing a vessel, the aperture portion of the device is pressed against the inside wall of the vessel with sufficient pressure to form an airtight seal between the inside of the device and the wall. While maintaining the airtight seal, the device is moved over the full inside surface of the cell. If there is a hole in the cell, the device which is very compliant will tend to collapse as it passes over the hole due to a resilient pressure drop created by the hole allowing the air to escape from the device to the atmosphere

  17. Quantifying Information Leak Vulnerabilities

    CERN Document Server

    Heusser, Jonathan

    2010-01-01

    Leakage of confidential information represents a serious security risk. Despite a number of novel, theoretical advances, it has been unclear if and how quantitative approaches to measuring leakage of confidential information could be applied to substantial, real-world programs. This is mostly due to the high complexity of computing precise leakage quantities. In this paper, we introduce a technique which makes it possible to decide if a program conforms to a quantitative policy which scales to large state-spaces with the help of bounded model checking. Our technique is applied to a number of officially reported information leak vulnerabilities in the Linux Kernel. Additionally, we also analysed authentication routines in the Secure Remote Password suite and of a Internet Message Support Protocol implementation. Our technique shows when there is unacceptable leakage; the same technique is also used to verify, for the first time, that the applied software patches indeed plug the information leaks. This is the f...

  18. Aspects of leak detection

    Energy Technology Data Exchange (ETDEWEB)

    Chivers, T.C. [Berkeley Technology Centre, Glos (United Kingdom)

    1997-04-01

    A requirement of a Leak before Break safety case is that the leakage from the through wall crack be detected prior to any growth leading to unacceptable failure. This paper sets out to review some recent developments in this field. It does not set out to be a comprehensive guide to all of the methods available. The discussion concentrates on acoustic emission and how the techniques can be qualified and deployed on operational plant.

  19. ON JAVASCRIPT MEMORY LEAKS

    OpenAIRE

    Ilyushin, Evgeniy; Namiot, Dmitry

    2015-01-01

    As soon as more and more the modern applications are deployed on the web, JavaScript has become a mainstream programming environment. JavaScript applications nowadays are big programming systems. We can mention here web portals, online games, graphics, media management, and even data science. Of course, the memory management is a very important problem, especially, for the dynamic programming languages. In this paper, we provide a survey of memory leaks patterns in JavaScript

  20. Leak test fitting

    Science.gov (United States)

    Pickett, P.T.

    A hollow fitting for use in gas spectrometry leak testing of conduit joints is divided into two generally symmetrical halves along the axis of the conduit. A clip may quickly and easily fasten and unfasten the halves around the conduit joint under test. Each end of the fitting is sealable with a yieldable material, such as a piece of foam rubber. An orifice is provided in a wall of the fitting for the insertion or detection of helium during testing. One half of the fitting also may be employed to test joints mounted against a surface.

  1. Mobile leak testing system

    International Nuclear Information System (INIS)

    The design and implementation are described of a mobile testing unit ULTRATEST M for helium leak tests. The equipment has been developed by Leybold-Heraeus GmbH in Cologne and is in-built in a Mercedes-Benz 208 van. The equipment is designed for the operative use in assembly and construction of nuclear power plants and its throughput is sufficient for checking the whole upper reactor block. It may also be used for removing defects of vacuum equipment requiring a high level of tightness or equally demanding equipment used in the chemical industry. Experience with the equipment is described. (B.S.)

  2. Variable leak gas source

    Science.gov (United States)

    Henderson, Timothy M.; Wuttke, Gilbert H.

    1977-01-01

    A variable leak gas source and a method for obtaining the same which includes filling a quantity of hollow glass micro-spheres with a gas, storing said quantity in a confined chamber having a controllable outlet, heating said chamber above room temperature, and controlling the temperature of said chamber to control the quantity of gas passing out of said controllable outlet. Individual gas filled spheres may be utilized for calibration purposes by breaking a sphere having a known quantity of a known gas to calibrate a gas detection apparatus.

  3. Deconstructing Gender Stereotypes in Leak

    Directory of Open Access Journals (Sweden)

    Nengah Bawa Atmadja

    2015-05-01

    Full Text Available The belief of Balinese people towards leak still survive. Leak is a magic based on durgaism that can transform a person from human to another form, such as apes, pigs, etc. People tend to regard leak as evil. In general, the evilness is constructed in gender stereotypes, so it is identified that leak are always women. This idea is a power game based on the ideology of patriarchy that provides legitimacy for men to dominate women with a plea for social harmony. As a result, women are marginalized in the Balinese society. Women should be aware of so it would provide encouragement for them to make emancipatory changes dialogically. Kepercayaan orang Bali terhadap leak tetap bertahan sampai saat ini. Leak adalah sihir yang berbasiskan durgaisme yang dapat mengakibatkan seseorang bisa merubah bentuk dari manusia ke wujud yang lain, misalnya kera, babi, dll. Leak termasuk magi hitam sehingga dinilai bersifat jelek. Pada umumnya perempuan diidentikkan dengan leak sehingga melahirkan asumsi yang bermuatan steriotip gender bahwa leak = perempuan. Gagasan ini merupakan permainan kekuasaan berbasis ideologi patriarkhi dan sekaligus memberikan legitimasi bagi laki-laki untuk menguasai perempuan dengan dalih demi keharmonisan sosial. Akibatnya, perempuan menjadi termarginalisasi pada masyarakat Bali.  Perempuan harus menyadarinya sehingga memberikan dorongan bagi mereka untuk melakukan perubahan secara dialogis emansipatoris.

  4. 重度肺毛细血管渗漏并发严重低血容量性休克的液体复苏:附1例报告%Fluid resuscitation in a patient with severe hypovolemic shock and severe pulmonary capil-lary leak

    Institute of Scientific and Technical Information of China (English)

    谢海庭; 李忠丽; 吴多斌; 常平; 刘占国

    2014-01-01

    对1例体外超声碎石时出现“呼吸困难、血压低,伴心悸、胸闷、全身大汗”临床考虑为重度肺毛细血管渗漏、低血容量性休克的患者行脉搏波指示连续心排血量(PiCCO)技术监测,动态观察各血流动力学指标,根据血管外肺水指数(EVLWI)及全心舒张末容积指数(GEDI)控制性补液,纠正休克治疗过程中该患者心排量(CO)和GEDI一直偏低,EVLWI最高达到了32 ml/kg,持续可吸出大量淡红色稀薄血性痰,高呼吸机支持参数下氧饱和度仍然非常低。为纠正休克同时减轻肺水肿选择了控制性补液,即当GEDI低于500 ml/m2时选择补充胶体液,当GEDI高于500 ml/m2时减少补液量并减慢补液速度,保持轻度容量不足并及时调整呼吸机参数,经治疗后患者胸片肺水肿逐渐好转,乳酸,肝肾功能,逐渐好转,6 d后停用升压药,10 d后脱呼吸机并拔除经口气管插管,25 d后顺利出院。在治疗过程中PiCCO监测有重要的指导意义。%A male patient undergoing extracorporeal ultrasound lithotripsy developed the symptoms of dyspnea, low blood pressure, palpitations, chest tightness, and sweating, and a clinical diagnosis of pulmonary capillary leak and hypovolemic shock was made. Pulse indicator continuous cardiac output (PiCCO) technique was used for resuscitation according to the measurements of extravascular lung water index (EVLWI) and global end-diastolic volume index (GEDI). The patient showed low levels of cardiac output (CO) and GEDI with a peak EVLWI of 32 ml/kg and profuse pink and thin sputum overflow from the trachea. The high ventilator support parameters failed to correct low oxygen saturation. Restricted fluid infusion was used to reduce pulmonary edema. Colloidal solution was given when GEDI was below 500 ml/m2, and the volume and fluid infusion rate were reduced for a GEDI higher than 500 ml/m2. Pulmonary edema was gradually reduced after the

  5. Inoperable HTS pressure sensor due to NaK leak. Final unusual occurrence report

    International Nuclear Information System (INIS)

    The report describes an inoperable pressure sensor in the primary heat transport system, due to a NaK leak between the transducer and bellows seal assembly. The pressure transducer capillary tube and seal assembly was replaced during a planned Heat Transport System test that required reduced sodium level, resulting in no schedule impact

  6. HAWAII LEAKING UNDERGROUND STORAGE TANKS

    Science.gov (United States)

    Point coverage of leaking underground storage tanks(LUST) for the state of Hawaii. The original database was developed and is maintained by the State of Hawaii, Dept. of Health. The point locations represent facilities where one or more leaking underground storage tank exists. ...

  7. Hermetic Seal Leak Detection Apparatus

    Science.gov (United States)

    Kelley, Anthony R. (Inventor)

    2013-01-01

    The present invention is a hermetic seal leak detection apparatus, which can be used to test for hermetic seal leaks in instruments and containers. A vacuum tight chamber is created around the unit being tested to minimize gas space outside of the hermetic seal. A vacuum inducing device is then used to increase the gas chamber volume inside the device, so that a slight vacuum is pulled on the unit being tested. The pressure in the unit being tested will stabilize. If the stabilized pressure reads close to a known good seal calibration, there is not a leak in the seal. If the stabilized pressure reads closer to a known bad seal calibration value, there is a leak in the seal. The speed of the plunger can be varied and by evaluating the resulting pressure change rates and final values, the leak rate/size can be accurately calculated.

  8. Analysis of SX farm leak histories - Historical leak model (HLM)

    International Nuclear Information System (INIS)

    This report uses readily available historical information to better define the volume, chemical composition, and Cs-137/Sr-90 amounts for leaks that have occurred in the past for tanks SX-108, SX-109, SX-111, and SX-112. In particular a Historical Leak Model (HLM) is developed that is a month by month reconciliation of tank levels, fill records, and calculated boil-off rates for these tanks. The HLM analysis is an independent leak estimate that reconstructs the tank thermal histories thereby deriving each tank's evaporative volume loss and by difference, its unaccounted losses as well. The HLM analysis was meant to demonstrate the viability of its approach, not necessarily to establish the HLM leak estimates as being definitive. Past leak estimates for these tanks have invariably resorted to soil wetting arguments but the extent of soil contaminated by each leak has always been highly uncertain. There is also a great deal of uncertainty with the HLM that was not quantified in this report, but will be addressed later. These four tanks (among others) were used from 1956 to 1975 for storage of high-level waste from the Redox process at Hanford. During their operation, tank waste temperatures were often as high as 150 C (300 F), but were more typically around 130 C. The primary tank cooling was by evaporation of tank waste and therefore periodic replacement of lost volume with water was necessary to maintain each tank's inventory. This active reflux of waste resulted in very substantial turnovers in tank inventory as well as significant structural degradation of these tanks. As a result of the loss of structural integrity, each of these tanks leaked during their active periods of operation. Unfortunately, the large turnover in tank volume associated with their reflux cooling has made a determination of leak volumes very difficult. During much of these tanks operational histories, inventory losses because of evaporative cooling could have effectively masked any volume

  9. Leak test adapter for containers

    Science.gov (United States)

    Hallett, Brian H.; Hartley, Michael S.

    1996-01-01

    An adapter is provided for facilitating the charging of containers and leak testing penetration areas. The adapter comprises an adapter body and stem which are secured to the container's penetration areas. The container is then pressurized with a tracer gas. Manipulating the adapter stem installs a penetration plug allowing the adapter to be removed and the penetration to be leak tested with a mass spectrometer. Additionally, a method is provided for using the adapter.

  10. Mapping urban pipeline leaks: Methane leaks across Boston

    International Nuclear Information System (INIS)

    Natural gas is the largest source of anthropogenic emissions of methane (CH4) in the United States. To assess pipeline emissions across a major city, we mapped CH4 leaks across all 785 road miles in the city of Boston using a cavity-ring-down mobile CH4 analyzer. We identified 3356 CH4 leaks with concentrations exceeding up to 15 times the global background level. Separately, we measured δ13CH4 isotopic signatures from a subset of these leaks. The δ13CH4 signatures (mean = −42.8‰ ± 1.3‰ s.e.; n = 32) strongly indicate a fossil fuel source rather than a biogenic source for most of the leaks; natural gas sampled across the city had average δ13CH4 values of −36.8‰ (±0.7‰ s.e., n = 10), whereas CH4 collected from landfill sites, wetlands, and sewer systems had δ13CH4 signatures ∼20‰ lighter (μ = −57.8‰, ±1.6‰ s.e., n = 8). Repairing leaky natural gas distribution systems will reduce greenhouse gas emissions, increase consumer health and safety, and save money. Highlights: ► We mapped 3356 methane leaks in Boston. ► Methane leaks in Boston carry an isotopic signature of pipeline natural gas. ► Replacing failing gas pipelines will provide safety, environmental, and economic benefits. - We identified 3356 methane leaks in Boston, with isotopic characteristics consistent with pipeline natural gas.

  11. Study on leak rate evaluation

    International Nuclear Information System (INIS)

    The Leak Before Break (LBB) concept is widely used in the nuclear industry to eliminate protective components previously accounting for dynamic effects of pipe rupture. A computer program LRCPC (Leak Rate Calculation of Pipe Crack) has been developed here to show detectable leak rates prior to crack growth instability. The program evaluates the LBB hypothesis for the pipe loads, material, crack length, and pipe geometry. The input stagnation conditions include subcooled or saturated liquid where the uncritical flow as well as the critical flow at the exit plane is considered, two-phrase mixture or saturated steam and superheated steam discharge at the exit plane. Calculation results are compared to the published calculating data. Effects of flow parameters such as friction on the critical mass flow rate are investigated. (author)

  12. Intramedullary capillary haemangioma.

    LENUS (Irish Health Repository)

    Kelleher, T

    2012-02-03

    Intramedullary capillary haemangioma is extremely rare and only four cases have been previously reported. We describe a further case, outlining the clinical, radiological, surgical and pathological features.

  13. Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach.

    Science.gov (United States)

    Cornell, Robert Frank; Hari, Parameswaran; Drobyski, William R

    2015-12-01

    Engraftment syndrome (ES) encompasses a continuum of periengraftment complications after autologous hematopoietic stem cell transplantation. ES may include noninfectious fever, skin rash, diarrhea, hepatic dysfunction, renal dysfunction, transient encephalopathy, and capillary leak features, such as noncardiogenic pulmonary infiltrates, hypoxia, and weight gain with no alternative etiologic basis other than engraftment. Given its pleiotropic clinical presentation, the transplant field has struggled to clearly define ES and related syndromes. Here, we present a comprehensive review of ES in all documented disease settings. Furthermore, we discuss the proposed risk factors, etiology, and clinical relevance of ES. Finally, our current approach to ES is included along with a proposed treatment algorithm for the management of this complication. PMID:26327628

  14. Variable gas leak rate valve

    Science.gov (United States)

    Eernisse, Errol P.; Peterson, Gary D.

    1976-01-01

    A variable gas leak rate valve which utilizes a poled piezoelectric element to control opening and closing of the valve. The gas flow may be around a cylindrical rod with a tubular piezoelectric member encircling the rod for seating thereagainst to block passage of gas and for reopening thereof upon application of suitable electrical fields.

  15. Leaking gas in the greenhouse

    International Nuclear Information System (INIS)

    Greenhouse gas emissions by the United Kingdom could be significantly reduced by replacement of old and leaking gas mains. Such a programme could even be cost-effective for the utility concerned. Calculations of gas leakage rates and the costs of saving emissions in terms of tonnes CDE (carbon dioxide equivalent) are given. (UK)

  16. Stochastic Consequence Analysis for Waste Leaks

    International Nuclear Information System (INIS)

    This analysis evaluates the radiological consequences of potential Hanford Tank Farm waste transfer leaks. These include ex-tank leaks into structures, underneath the soil, and exposed to the atmosphere. It also includes potential misroutes, tank overflow

  17. Stochastic Consequence Analysis for Waste Leaks

    Energy Technology Data Exchange (ETDEWEB)

    HEY, B.E.

    2000-05-31

    This analysis evaluates the radiological consequences of potential Hanford Tank Farm waste transfer leaks. These include ex-tank leaks into structures, underneath the soil, and exposed to the atmosphere. It also includes potential misroutes, tank overflow

  18. Simulation of leaking fuel rods

    International Nuclear Information System (INIS)

    The behaviour of failed fuel rods includes several complex phenomena. The cladding failure initiates the release of fission product from the fuel and in case of large defect even urania grains can be released into the coolant. In steady state conditions an equilibrium - diffusion type - release is expected. During transients the release is driven by a convective type leaching mechanism. There are very few experimental data on leaking WWER fuel rods. For this reason the activity measurements at the nuclear power plants provide very important information. The evaluation of measured data can help in the estimation of failed fuel rod characteristics and the prediction of transient release dynamics in power plant transients. The paper deals with the simulation of leaking fuel rods under steady state and transient conditions and describes the following new results: 1) A new algorithm has been developed for the simulation of leaking fuel rods under steady state conditions and the specific parameters of the model for the Paks NPP has been determined; 2) The steady state model has been applied to calculation of leaking fuel characteristics using iodine and noble gas activity measurement data; 3) A new computational method has been developed for the simulation of leaking fuel rods under transient conditions and the specific parameters for the Paks NPP has been determined; 4) The transient model has been applied to the simulation of shutdown process at the Paks NPP and for the prediction of the time and magnitude of 123I activity peak; 5) Using Paks NPP data a conservative value has been determined for the upper limit of the 123I release from failed fuel rods during transients

  19. Calibration of a leak detection spectrometer

    International Nuclear Information System (INIS)

    This paper describes a study of the possible methods for calibrating a leak detection spectrometer, and the estimation of outputs from the leaks is considered. With this in mind the question of sensitivity of leak detection is tackled on a very general level; first the sensitivity of the isolated instrument is determined, and then the sensitivity of an instrument connected to an installation where leaks may be suspected. Finally, practical solutions are proposed. (author)

  20. Genetics Home Reference: Parkes Weber syndrome

    Science.gov (United States)

    ... because of their color are sometimes called "port-wine stains." In people with Parkes Weber syndrome , capillary ... diagnosis or management of Parkes Weber syndrome: Gene Review: Gene Review: RASA1-Related Disorders Genetic Testing Registry: ...

  1. Hydrogen Leak Detection Sensor Database

    Science.gov (United States)

    Baker, Barton D.

    2010-01-01

    This slide presentation reviews the characteristics of the Hydrogen Sensor database. The database is the result of NASA's continuing interest in and improvement of its ability to detect and assess gas leaks in space applications. The database specifics and a snapshot of an entry in the database are reviewed. Attempts were made to determine the applicability of each of the 65 sensors for ground and/or vehicle use.

  2. Schlieren optics for leak detection

    Science.gov (United States)

    Peale, Robert E.; Ruffin, Alranzo B.

    1995-01-01

    The purpose of this research was to develop an optical method of leak detection. Various modifications of schlieren optics were explored with initial emphasis on leak detection of the plumbing within the orbital maneuvering system of the space shuttle (OMS pod). The schlieren scheme envisioned for OMS pod leak detection was that of a high contrast pattern on flexible reflecting material imaged onto a negative of the same pattern. We find that the OMS pod geometry constrains the characteristic length scale of the pattern to the order of 0.001 inch. Our experiments suggest that optical modulation transfer efficiency will be very low for such patterns, which will limit the sensitivity of the technique. Optical elements which allow a negative of the scene to be reversibly recorded using light from the scene itself were explored for their potential in adaptive single-ended schlieren systems. Elements studied include photochromic glass, bacteriorhodopsin, and a transmissive liquid crystal display. The dynamics of writing and reading patterns were studied using intensity profiles from recorded images. Schlieren detection of index gradients in air was demonstrated.

  3. Development of sodium leak detectors for PFBR

    International Nuclear Information System (INIS)

    Highlights: ► Sodium leak detection system developed for PFBR using diverse principle. ► Miniature, remotely locatable diverse leak detector developed for Main Vessel. ► Mutual inductance type leak detectors designed and adapted for different locations. ► Sodium Ionisation detectors used for area monitoring. ► Crosswire type leak detector designed, developed and tested. - Abstract: The 500 MWe Prototype Fast Breeder Reactor (PFBR) is under advanced stage of construction at Kalpakkam near Chennai in India. The wide and high operating temperature, highly chemically active nature of sodium and its reaction with air make the sodium instrumentation complex over the conventional instrumentation. Over the years, traditional instruments such as wire type leak detectors, spark plug type leak detectors were developed and used in different sodium systems. The redundant and diverse leak detection method calls for development of special instrumentation for sodium systems which include sodium ionization (leak) detector for detecting minute sodium leak in addition to those systems based on mutual inductance principle. For detection of sodium leak from reactor Main Vessel (MV), diverse methods are used such as miniature, remotely locatable, Mutual Inductance type Leak Detector(MILD) and specially modified spark plug type leak detector. The design of MILD is suitably modified for detecting leak in double wall pipes and Diverse Safety Rod drive Mechanism (DSRDM). Steam/water leak in steam generator produces hydrogen and leads to high pressure and temperature in the system. Rupture disc is used as a safety device which punctures itself due to sudden pressure rise. To detect the discharge of sodium and its reaction products at the downstream of the rupture disc due to bursting of the rupture disc, cross wire type leak detector has been designed, developed and tested. The selection of the leak detection system depends on the location where leak has to be detected. This paper

  4. Capillary saturation and desaturation.

    Science.gov (United States)

    Hilfer, R; Armstrong, R T; Berg, S; Georgiadis, A; Ott, H

    2015-12-01

    Capillary desaturation experiments produce disconnected (trapped) ganglia of mesoscopic sizes intermediate between pore size and system size. Experimental evidence for interactions between these mesoscale clusters during desaturation is analyzed and discussed within the established microscopic and macroscopic laws of Newton, Young-Laplace, and Darcy. A theoretical expression for capillary number correlations is introduced that seems to have remained unnoticed. It expresses capillary desaturation curves in terms of stationary capillary pressures and relative permeabilities. The theoretical expression shows that the plateau saturation in capillary desaturation curves may in general differ from the residual nonwetting saturation defined through the saturation limit of the main hysteresis loop. Hysteresis effects as well as the difference between wetting and nonwetting fluids are introduced into the analysis of capillary desaturation experiments. The article examines experiments with different desaturation protocols and discusses the existence of a mesoscopic length scale intermediate between pore scale and sample scale. The theoretical expression is derived entirely within the existing traditional theory of two-phase flow in porous media and compared to a recent experiment. PMID:26764820

  5. Capillary saturation and desaturation

    Science.gov (United States)

    Hilfer, R.; Armstrong, R. T.; Berg, S.; Georgiadis, A.; Ott, H.

    2015-12-01

    Capillary desaturation experiments produce disconnected (trapped) ganglia of mesoscopic sizes intermediate between pore size and system size. Experimental evidence for interactions between these mesoscale clusters during desaturation is analyzed and discussed within the established microscopic and macroscopic laws of Newton, Young-Laplace, and Darcy. A theoretical expression for capillary number correlations is introduced that seems to have remained unnoticed. It expresses capillary desaturation curves in terms of stationary capillary pressures and relative permeabilities. The theoretical expression shows that the plateau saturation in capillary desaturation curves may in general differ from the residual nonwetting saturation defined through the saturation limit of the main hysteresis loop. Hysteresis effects as well as the difference between wetting and nonwetting fluids are introduced into the analysis of capillary desaturation experiments. The article examines experiments with different desaturation protocols and discusses the existence of a mesoscopic length scale intermediate between pore scale and sample scale. The theoretical expression is derived entirely within the existing traditional theory of two-phase flow in porous media and compared to a recent experiment.

  6. Leak detection of KNI seals

    International Nuclear Information System (INIS)

    In Unit 3 and 4 of the Paks Nuclear Power Plant, Hungary, KNI type seals are used as lead-throughs with conical nickel sealing rings. Their failure can be critical for the operation of the reactor. An Acoustical Leak Detection System (ALDS) was constructed and tested for the operational testing of the seals. Some individual papers are presented in this collection on the calibration and testing of the ALDS intended to be placed on the top of the reactor vessels. The papers include simulation measurements of Unit 3 of NPP, laboratory experiments, evaluation of measurements, and further development needs with the ALDS. (R.P.) 50 figs.; 19 tabs

  7. Leak detection capability in CANDU reactors

    International Nuclear Information System (INIS)

    This paper addresses the moisture leak detection capability of Ontario Hydro CANDU reactors which has been demonstrated by performing tests on the reactor. The tests confirmed the response of the annulus gas system (AGS) to the presence of moisture injected to simulate a pressure tube leak and also confirmed the dew point response assumed in leak before break assessments. The tests were performed on Bruce A Unit 4 by injecting known and controlled rates of heavy water vapor. To avoid condensation during test conditions, the amount of moisture which could be injected was small (2-3.5 g/hr). The test response demonstrated that the AGS is capable of detecting and annunciating small leaks. Thus confidence is provided that it would alarm for a growing pressure tube leak where the leak rate is expected to increase to kg/hr rapidly. The measured dew point response was close to that predicted by analysis

  8. Leak detection capability in CANDU reactors

    Energy Technology Data Exchange (ETDEWEB)

    Azer, N.; Barber, D.H.; Boucher, P.J. [and others

    1997-04-01

    This paper addresses the moisture leak detection capability of Ontario Hydro CANDU reactors which has been demonstrated by performing tests on the reactor. The tests confirmed the response of the annulus gas system (AGS) to the presence of moisture injected to simulate a pressure tube leak and also confirmed the dew point response assumed in leak before break assessments. The tests were performed on Bruce A Unit 4 by injecting known and controlled rates of heavy water vapor. To avoid condensation during test conditions, the amount of moisture which could be injected was small (2-3.5 g/hr). The test response demonstrated that the AGS is capable of detecting and annunciating small leaks. Thus confidence is provided that it would alarm for a growing pressure tube leak where the leak rate is expected to increase to kg/hr rapidly. The measured dew point response was close to that predicted by analysis.

  9. Acoustic emission leak monitoring system LMS-96

    International Nuclear Information System (INIS)

    On-line acoustic emission leak monitoring under industrial conditions of nuclear power plants is a problem with specific features setting specific demands on the leak monitoring system. The paper briefly reviews those problems (attenuation pattern of a real structure, acoustic background, alarm system, etc.) and the solution of some of them is discussed. Information is presented on the Acoustic Emission Leak Monitoring System LMS-96 by SKODA NUCLEAR MACHINERY and the system's function is briefly described. (author)

  10. Formen von Informalität: "Policy-Leaks" vs. "Politics-Leaks"

    OpenAIRE

    Bieber, Christoph

    2012-01-01

    Die mediale Darstellung von Leaks lässt leicht darauf schließen, dass Leaks ein zwar interessantes, da neues, aber zumindest einheitliches Phänomen im internationalen System darstellen. Christoph Bieber von der Universität Duisburg-Essen bricht mit dieser Vor- und Darstellung, indem er anhand bestimmter vergangener Veröffentlichungen unterschiedliche Arten des Leaking differenziert, und dabei sowohl „Policy-“ wie auch „Politics-“ Leaks identifiziert...

  11. A mathematical model for leak location and leak area determination in pipeline networks

    OpenAIRE

    Oyedokun O.I.; Oke S.A.; Ighravwe D.E.

    2013-01-01

    Prompt leak location and leak area determination in oil and gas pipeline installations is an indispensable approach to controlling petroleum products wastages in pipes. However, there is an evident lack of literature information on this subject. In this paper, we modelled leak location detection and leak area determination in pipes by applying two methodologies and gave an illustrative example using simulated data with the aid of Matlab. A comparison of the...

  12. How Capillary Rafts Sink

    CERN Document Server

    Protiere, S; Aristoff, J; Stone, H

    2010-01-01

    We present a fluid dynamics video showing how capillary rafts sink. Small objects trapped at an interface are very common in Nature (insects walking on water, ant rafts, bubbles or pollen at the water-air interface, membranes...) and are found in many multiphase industrial processes. Thanks to Archimedes principle we can easily predict whether an object sinks or floats. But what happens when several small particles are placed at an interface between two fluids. In this case surface tension also plays an important role. These particles self-assemble by capillarity and thus form what we call a "capillary raft". We show how such capillary rafts sink for varying sizes of particles and define how this parameter affects the sinking process.

  13. Leak detector of liquid sodium

    International Nuclear Information System (INIS)

    Object: To arrange a cable core connected to a leakage current detector on the outer wall of piping for liquid sodium, devices or the like and apply a voltage to said core and outer wall to quickly and securely detect the leakage of liquid sodium. Structure: A cable, which is composed of metal coating formed of metal material (copper, steel, stainless, etc.) which is apt to be corroded by reaction products of liquid sodium with water and oxygen in air, and metal oxide (such as magnesium oxide, beryllium oxide, aluminum oxide) as an electric insulator is arranged on the outer wall of pipes or devices. In the event sodium is leaked from the pipes or devices, said metal coating and the insulator are corroded, and the leakage of sodium is sensed by a leakage current detector through the core in the cable. (Kamimura, M.)

  14. Capillary electrophoresis - electrospray ionization mass spectrometry in small diameter capillaries

    Energy Technology Data Exchange (ETDEWEB)

    Wahl, J.H.; Goodlett, D.R.; Udseth, H.R.; Smith, R.D.

    1992-06-01

    Methods (such as small inner diameter capillaries) are being explored to increase analyte sensitivity in capillary electrophoresis- electrospray ionization/mass spectroscopy(CE-ESI/MS). Results are reported for melittin in a protein mixture, with 10 to 100 {mu}m ID capillaries; and for a mixture of aprotinin, cytochrome c, myoglobin, and carbonic anhydrase, with 5 to 50 {mu}m ID capillaries. It is shown that an increase in solute sensitivity occurs when small ID capillaries ({lt} 20 {mu}m) are used in CE-ESI/MS for both a peptide and a protein mixture. 3 figs. (DLC)

  15. Leak Tightness of LHC Cold Vacuum Systems

    CERN Document Server

    Cruikshank, P; Maan, M; Mourier, L; Perrier-Cornet, A; Provot, N

    2011-01-01

    The cold vacuum systems of the LHC machine have been in operation since 2008. While a number of acceptable helium leaks were known to exist prior to cool down and have not significantly evolved over the last years, several new leaks have occurred which required immediate repair activities or mitigating solutions to permit operation of the LHC. The LHC vacuum system is described together with a summary and timetable of known air and helium leaks and their impact on the functioning of the cryogenic and vacuum systems. Where leaks have been investigated and repaired, the cause and failure mechanism is described. We elaborate the mitigating solutions that have been implemented to avoid degradation of known leaks and minimize their impact on cryogenic operation and LHC availability, and finally a recall of the consolidation program to be implemented in the next LHC shutdown.

  16. Microwave Radar Detection of Gas Pipeline Leaks

    Science.gov (United States)

    Gopalsami, N.; Kanareykin, D. B.; Asanov, V.; Bakhtiari, S.; Raptis, A. C.

    2003-03-01

    We are developing a microwave radar sensing and imaging system to detect and locate gas leaks in natural gas pipelines. The underlying detection principle is radar backscattering from the index-of-refraction inhomogeneities introduced by the dispersion of methane in air. An essential first step in the development effort is modeling to estimate the radar cross section. This paper describes the modeling results and the experimental efforts underway to validate the model. For the case of leaks from small holes in a pressurized gas pipeline, we modeled the gas dynamics of the leak jet to determine the plume geometry and the variation of methane concentration in air as a function of distance from the leak source. From the static and dynamic changes in the index of refraction in the turbulent plume, the radar backscatter cross sections were calculated. The results show that the radar cross sections of the leak plumes should be detectable by special-purpose radars.

  17. Leak Signature Space: An Original Representation for Robust Leak Location in Water Distribution Networks

    Directory of Open Access Journals (Sweden)

    Myrna V. Casillas

    2015-03-01

    Full Text Available In this paper, an original model-based scheme for leak location using pressure sensors in water distribution networks is introduced. The proposed approach is based on a new representation called the Leak Signature Space (LSS that associates a specific signature to each leak location being minimally affected by leak magnitude. The LSS considers a linear model approximation of the relation between pressure residuals and leaks that is projected onto a selected hyperplane. This new approach allows to infer the location of a given leak by comparing the position of its signature with other leak signatures. Moreover, two ways of improving the method’s robustness are proposed. First, by associating a domain of influence to each signature and second, through a time horizon analysis. The efficiency of the method is highlighted by means of a real network using several scenarios involving different number of sensors and considering the presence of noise in the measurements.

  18. Acoustic leak detector in Monju steam generator

    International Nuclear Information System (INIS)

    Acoustic leak detectors are equipped with the Monju steam generators for one of the R and D activities, which are the same type of the detectors developed in the PNC 50MW Steam Generator Test Facility. Although they are an additional leak detection system to the regular one in Monju SG, they would also detect the intermediate or large leaks of the SG tube failures. The extrapolation method of a background noise analysis is expected to be verified by Monju SG data. (author). 4 figs

  19. Study of capillary and chemical cover applied to reclamation of uranium mine tailings and rock waste

    International Nuclear Information System (INIS)

    The aim of this work is to evaluate the feasibility and the efficiency of the cover applied to uraniferous mining residues with natural products. The studied cover answers three functions, separately studied: the water input control, the oxygen input and radon output control, the infiltrations chemistry control. The infiltration control will be realized by the implementing of a capillary cover integrating a clayey layer. This layer ensures also the tightness function and limit the radon migration to the atmosphere. By a control of the water input in the storage, the capillary cover minimizes the polluted water bulks and limits the pollutants leaking in the environment. (A.L.B.)

  20. Leaking Underground Storage Tank Sites in Iowa

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — Leaking Underground Storage Tank (LUST) sites where petroleum contamination has been found. There may be more than one LUST site per UST site.

  1. Detection of primary coolant leaks in NPP

    International Nuclear Information System (INIS)

    The thermo-hydraulic analyses of the SG box behaviour of Kozloduy NPP units 3 and 4 in case of small primary circuit leaks and during normal operation of the existing ventilation systems in order to determine the detectable leakages from the primary circuit by analysing different parameters used for the purposes of 'Leak before break' concept, performed by ENPRO Consult Ltd. are presented. The following methods for leak detection: measurement of relative air humidity in SG box (can be used for detection of leaks with flow rate 3.78 l/min within one hour at ambient parameters - temperature 400 - 600C and relative humidity form 30% to 60%); measurement of water level in SG box sumps (can not be used for reliable detection of small primary circuit leakages with flow rate about 3.78 l/min); measurement of gaseous radioactivity in SG box( can be used as a general global indication for detection of small leakages from the primary circuit); measurement of condensate flow after the air coolers of P-1 venting system (can be used for primary circuit leak detection) are considered. For determination of the confinement behaviour, a model used with computer code MELCOR has been developed by ENPRO Consult Ltd. A brief summary based on the capabilities of the different methods of leak detection, from the point of view of the applicability of a particular method is given. For both Units 3 and 4 of Kozloduy NPP a qualified complex system for small leak detection is planned to be constructed. Such a system has to unite the following systems: acoustic system for leak detection 'ALUS'; system for control of the tightness of the main primary circuit pipelines by monitoring the local humidity; system for primary circuit leakage detection by measuring condensate run-off in collecting tank after ventilation system P-1 air coolers

  2. Wireless sensor network for sodium leak detection

    International Nuclear Information System (INIS)

    Highlights: ► Early detection of sodium leak is mandatory in any reactor handling liquid sodium. ► Wireless sensor networking technology has been introduced for detecting sodium leak. ► We designed and developed a wireless sensor node in-house. ► We deployed a pilot wireless sensor network for handling nine sodium leak signals. - Abstract: To study the mechanical properties of Prototype Fast Breeder Reactor component materials under the influence of sodium, the IN Sodium Test (INSOT) facility has been erected and commissioned at Indira Gandhi Centre for Atomic Research. Sodium reacts violently with air/moisture leading to fire. Hence early detection of sodium leak if any is mandatory for such plants and almost 140 sodium leak detectors are placed throughout the loop. All these detectors are wired to the control room for data collection and monitoring. To reduce the cost, space and maintenance that are involved in cabling, the wireless sensor networking technology has been introduced in the sodium leak detection system of INSOT. This paper describes about the deployment details of the pilot wireless sensor network and the measures taken for the successful deployment.

  3. Capillary permeability in adipose tissue

    DEFF Research Database (Denmark)

    Paaske, W P; Nielsen, S L

    1976-01-01

    A method for measurement of capillary permeability using external registration of gamma emitting isotopes after close arterial bolus injection was applied to the isolated inguinal fat pad in slightly fasting rabbits. An average extraction of 26 per cent for 51Cr-EDTA was found at a plasma flow of...... about 7 ml/100 g-min. This corresponds to a capillary diffusion capacity of 2.0 ml/100 g-min which is half the value reported for vasodilated skeletal muscle having approximately twice as great capillary surface area. Thus, adipose tissue has about the same capillary permeability during slight metabolic...

  4. Evaluation of advanced and current leak detection systems

    International Nuclear Information System (INIS)

    The objective of this project is to assess the reliability of leak detection technology for LWRs and evaluate advanced acoustic leak detection concepts for detection, location, and characterization of leaks. The FY 1987 scope includes: (1) Completing update of review of reliability of leak detection systems; (2) Completing evaluation of acoustic leak detection for in-reactor detection, discrimination, and location of leaks through laboratory testing of valves and cracks (including integranular stress corrosion cracks (IGSCCs)) with leak rates of 1-10 gal/min; (3) Completing evaluation of techniques to discriminate crack leaks from valve and seal leaks; and (4) Prepare draft document (guidance manual) for acoustic leak monitoring of reactor primary systems

  5. Remote leak localization approach for fusion machines

    Energy Technology Data Exchange (ETDEWEB)

    Durocher, Au., E-mail: aurelien.durocher@cea.fr [CEA-IRFM, F-13108 Saint Paul-Lez-Durance (France); Bruno, V.; Chantant, M.; Gargiulo, L. [CEA-IRFM, F-13108 Saint Paul-Lez-Durance (France); Gherman, T. [Floralis UJF Filiale, F-38610 Gières (France); Hatchressian, J.-C.; Houry, M.; Le, R.; Mouyon, D. [CEA-IRFM, F-13108 Saint Paul-Lez-Durance (France)

    2013-10-15

    Highlights: ► Description of leaks issue. ► Selection of leak localization concepts. ► Qualification of leak localization concepts. -- Abstract: Fusion machine operation requires high-vacuum conditions and does not tolerate water or gas leak in the vacuum vessels, even if they are micrometric. Tore Supra, as a fully actively cooled tokamak, has got a large leak management experience; 34 water leaks occurred since the beginning of its operation in 1988. To handle this issue, after preliminary machine protection phases, the current process for leak localization is based on water or helium pressurization network by network. It generally allows the identification of a set of components where the leakage element is located. However, the unique background of CEA-IRFM laboratory points needs of accuracy and promptness out in the leak localization process. Moreover, in-vessel interventions have to be performed trying to minimize time and risks for the persons. They are linked to access conditions, radioactivity, tracer gas high pressure and vessel conditioning. Remote operation will be one of the ways to improve these points on future fusion machines. In this case, leak sensors would have to be light weight devices in order to be integrated on a carrier or to be located outside with a sniffing process set up. A leak localization program is on-going at CEA-IRFM Laboratory with the first goal of identifying and characterizing relevant concepts to localize helium or water leaks on ITER. In the same time, CEA has developed robotic carrier for effective in-vessel intervention in a hostile environment. Three major tests campaigns with the goal to identify leak sensors have been achieved on several CEA test-beds since 2010. Very promising results have been obtained: relevant scenario of leak localization performed, concepts tested in a high volume test-bed called TITAN, and, in several conditions of pressure and temperature (ultrahigh vacuum to atmospheric pressure and 20

  6. Remote leak localization approach for fusion machines

    International Nuclear Information System (INIS)

    Highlights: ► Description of leaks issue. ► Selection of leak localization concepts. ► Qualification of leak localization concepts. -- Abstract: Fusion machine operation requires high-vacuum conditions and does not tolerate water or gas leak in the vacuum vessels, even if they are micrometric. Tore Supra, as a fully actively cooled tokamak, has got a large leak management experience; 34 water leaks occurred since the beginning of its operation in 1988. To handle this issue, after preliminary machine protection phases, the current process for leak localization is based on water or helium pressurization network by network. It generally allows the identification of a set of components where the leakage element is located. However, the unique background of CEA-IRFM laboratory points needs of accuracy and promptness out in the leak localization process. Moreover, in-vessel interventions have to be performed trying to minimize time and risks for the persons. They are linked to access conditions, radioactivity, tracer gas high pressure and vessel conditioning. Remote operation will be one of the ways to improve these points on future fusion machines. In this case, leak sensors would have to be light weight devices in order to be integrated on a carrier or to be located outside with a sniffing process set up. A leak localization program is on-going at CEA-IRFM Laboratory with the first goal of identifying and characterizing relevant concepts to localize helium or water leaks on ITER. In the same time, CEA has developed robotic carrier for effective in-vessel intervention in a hostile environment. Three major tests campaigns with the goal to identify leak sensors have been achieved on several CEA test-beds since 2010. Very promising results have been obtained: relevant scenario of leak localization performed, concepts tested in a high volume test-bed called TITAN, and, in several conditions of pressure and temperature (ultrahigh vacuum to atmospheric pressure and 20

  7. Laser-Pulse/Fiber-Optic Liquid-Leak Detector

    Science.gov (United States)

    Padgett, M. E.

    1986-01-01

    Several potential leak sites monitored using single sensing fiber. Fluid systems monitored quickly for leaks in remote, hazardous, or inaccessible locations by system of compact, lightweight fiber-optic leak sensors presently undergoing development. Sensors installed at potential leak sites as joints, couplings, and fittings. Sensor read by sending laser pulse along fiber, then noting presence or relative amplitude of return pulse. Leak-monitoring technique applicable to wide range of fluid systems and minimizes human exposure to toxic or dangerous fluids.

  8. Field tests and commercialization of natural gas leak detectors

    Energy Technology Data Exchange (ETDEWEB)

    Choi, D.S.; Jeon, J.S.; Kim, K.D.; Cho, Y.A. [R and D Center, Korea Gas Corporation, Ansan (Korea)

    1999-09-01

    Objectives - (1) fields test of industrial gas leak detection monitoring system. (2) commericialization of residential gas leak detector. Contents - (1) five sets of gas leak detection monitoring system were installed at natural gas transmition facilities and tested long term stability and their performance. (2) improved residential gas leak detector was commercialised. Expected benefits and application fields - (1) contribution to the improvement of domestic gas sensor technology. (2) localization of fabrication technology for gas leak detectors. 23 refs., 126 figs., 37 tabs.

  9. Single-Shell Tanks Leak Integrity Elements/ SX Farm Leak Causes and Locations - 12127

    International Nuclear Information System (INIS)

    Washington River Protection Solutions, LLC (WRPS) developed an enhanced single-shell tank (SST) integrity project in 2009. An expert panel on SST integrity was created to provide recommendations supporting the development of the project. One primary recommendation was to expand the leak assessment reports (substitute report or LD-1) to include leak causes and locations. The recommendation has been included in the M-045-91F Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) as one of four targets relating to SST leak integrity. The 241-SX Farm (SX Farm) tanks with leak losses were addressed on an individual tank basis as part of LD-1. Currently, 8 out of 23 SSTs that have been reported to having a liner leak are located in SX Farm. This percentage was the highest compared to other tank farms which is why SX Farm was analyzed first. The SX Farm is comprised of fifteen SSTs built 1953-1954. The tanks are arranged in rows of three tanks each, forming a cascade. Each of the SX Farm tanks has a nominal 1-million-gal storage capacity. Of the fifteen tanks in SX Farm, an assessment reported leak losses for the following tanks: 241-SX-107, 241-SX-108, 241-SX-109, 241-SX- 111, 241-SX-112, 241-SX-113, 241-SX-114 and 241-SX-115. The method used to identify leak location consisted of reviewing in-tank and ex-tank leak detection information. This provided the basic data identifying where and when the first leaks were detected. In-tank leak detection consisted of liquid level measurement that can be augmented with photographs which can provide an indication of the vertical leak location on the sidewall. Ex-tank leak detection for the leaking tanks consisted of soil radiation data from laterals and dry-wells near the tank. The in-tank and ex-tank leak detection can provide an indication of the possible leak location radially around and under the tank. Potential leak causes were determined using in-tank and ex-tank information that is not directly related to

  10. SINGLE-SHELL TANKS LEAK INTEGRITY ELEMENTS/SX FARM LEAK CAUSES AND LOCATIONS - 12127

    Energy Technology Data Exchange (ETDEWEB)

    VENETZ TJ; WASHENFELDER D; JOHNSON J; GIRARDOT C

    2012-01-25

    Washington River Protection Solutions, LLC (WRPS) developed an enhanced single-shell tank (SST) integrity project in 2009. An expert panel on SST integrity was created to provide recommendations supporting the development of the project. One primary recommendation was to expand the leak assessment reports (substitute report or LD-1) to include leak causes and locations. The recommendation has been included in the M-045-9IF Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) as one of four targets relating to SST leak integrity. The 241-SX Farm (SX Farm) tanks with leak losses were addressed on an individual tank basis as part of LD-1. Currently, 8 out of 23 SSTs that have been reported to having a liner leak are located in SX Farm. This percentage was the highest compared to other tank farms which is why SX Farm was analyzed first. The SX Farm is comprised of fifteen SSTs built 1953-1954. The tanks are arranged in rows of three tanks each, forming a cascade. Each of the SX Farm tanks has a nominal I-million-gal storage capacity. Of the fifteen tanks in SX Farm, an assessment reported leak losses for the following tanks: 241-SX-107, 241-SX-108, 241-SX-109, 241-SX-111, 241-SX-112, 241-SX-113, 241-SX-114 and 241-SX-115. The method used to identify leak location consisted of reviewing in-tank and ex-tank leak detection information. This provided the basic data identifying where and when the first leaks were detected. In-tank leak detection consisted of liquid level measurement that can be augmented with photographs which can provide an indication of the vertical leak location on the sidewall. Ex-tank leak detection for the leaking tanks consisted of soil radiation data from laterals and drywells near the tank. The in-tank and ex-tank leak detection can provide an indication of the possible leak location radially around and under the tank. Potential leak causes were determined using in-tank and ex-tank information that is not directly related to

  11. Tapered capillary optics

    Science.gov (United States)

    Hirsch, Gregory

    1998-01-01

    A metal or glass wire is etched with great precision into a very narrowly tapering cone which has the shape of the desired final capillary-optics bore. By controlling the rate of removal of the wire from an etchant bath, a carefully controlled taper is produced. A sensor measures the diameter of the wire as it leaves the surface of the etchant. This signal is used for feedback control of the withdrawal speed. The etched wire undergoes a treatment to produce an extremely low surface-roughness. The etched and smoothed wire is coated with the material of choice for optimizing the reflectivity of the radiation being focused. This could be a vacuum evaporation, sputtering, CVD or aqueous chemical process. The coated wire is either electroplated, built up with electroless plating, or encapsulated in a polymer cylinder such as epoxy to increase the diameter of the wire for easier handling and greater robustness. During this process, the wire is vertically oriented and tensioned to assure that the wire is absolutely straight. The coated and electroformed wire is bonded to a flat, rigid substrate and is then periodically segmented by cutting or etching a series of narrow slits or grooves into the wire. The wire is vertically oriented and tensioned during the bonding process to assure that it is straight. The original wire material is then chemically etched away through the slits or otherwise withdrawn to leave the hollow internal bore of the final tapered-capillary optical element.

  12. Biliary leaks after laparoscopic cholecystectomy:timetostentortimetodrain

    Institute of Scientific and Technical Information of China (English)

    Haim Pinkas; Patrick G. Brady

    2008-01-01

    BACKGROUND: Endoscopic retrograde cholangiopan-creatography (ERCP) with placement of a biliary stent or nasobiliary (NB) drain is the procedure of choice for treatment of post-cholecystectomy bile duct leaks. The aim of this study was to compare the effect of NB drainage versus internal biliary stenting on rates of leak closure, time elapsed until drain or stent removal, length of hospital stay and number of required endoscopic procedures. METHODS: Charts were reviewed on 20 patients who underwent laparoscopic cholecystectomy complicated by Luschka or cystic duct leak. Ten patients were treated with NB drains connected to low intermittent suction and repeat NB cholangiograms were performed until leak closure was observed. Ten patients were treated with internal biliary stents. Biliary sphincterotomies were performed for stone extraction or a presumed papillary stenosis. Large bilomas were drained percutaneously prior to stenting. RESULTS: In all 20 patients, a cholangiogram and successful placement of a NB drain or internal stent was achieved. Four patients (20%) were found to have bile duct stones, which were extracted following a sphincterotomy. Sixteen patients required percutaneous drains to evacuate large bilomas prior to biliary instrumentation. Fifteen cystic duct leaks and 5 Luschka duct leaks were reviewed. There were no complications related to ERCP. Closure of the leak was documented within 2 to 11 days (mean 4.7±0.9 days) in patients receiving a NB drain. The drains were removed non-endoscopically following leak closure. The internal stent group required stenting for 14 to 53 days (mean 29.1±4.4 days). The stent was then removed endoscopically after documentation of leak closure. Bile leaks following laparoscopic cholecystectomy closed rapidly after NB drainage and did not require repeat endoscopy for removal of the NB drain, resulting in fewer ERCPs required for treatment of biliary leaks. Internal biliary stents were in place longer owing

  13. Operational Philosophy Concerning Manned Spacecraft Cabin Leaks

    Science.gov (United States)

    DeSimpelaere, Edward

    2011-01-01

    The last thirty years have seen the Space Shuttle as the prime United States spacecraft for manned spaceflight missions. Many lessons have been learned about spacecraft design and operation throughout these years. Over the next few decades, a large increase of manned spaceflight in the commercial sector is expected. This will result in the exposure of commercial crews and passengers to many of the same risks crews of the Space Shuttle have encountered. One of the more dire situations that can be encountered is the loss of pressure in the habitable volume of the spacecraft during on orbit operations. This is referred to as a cabin leak. This paper seeks to establish a general cabin leak response philosophy with the intent of educating future spacecraft designers and operators. After establishing a relative definition for a cabin leak, the paper covers general descriptions of detection equipment, detection methods, and general operational methods for management of a cabin leak. Subsequently, all these items are addressed from the perspective of the Space Shuttle Program, as this will be of the most value to future spacecraft due to similar operating profiles. Emphasis here is placed upon why and how these methods and philosophies have evolved to meet the Space Shuttle s needs. This includes the core ideas of: considerations of maintaining higher cabin pressures vs. lower cabin pressures, the pros and cons of a system designed to feed the leak with gas from pressurized tanks vs. using pressure suits to protect against lower cabin pressures, timeline and consumables constraints, re-entry considerations with leaks of unknown origin, and the impact the International Space Station (ISS) has had to the standard Space Shuttle cabin leak response philosophy. This last item in itself includes: procedural management differences, hardware considerations, additional capabilities due to the presence of the ISS and its resource, and ISS docking/undocking considerations with a

  14. Standard practice for leaks using ultrasonics

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2011-01-01

    1.1 Practice A, Pressurization—This practice covers procedures for calibration of ultrasonic instruments, location, and estimated measurements of gas leakage to atmosphere by the airborne ultrasonic technique. 1.2 In general practice this should be limited to leaks detected by two classifications of instruments, Class I and Class II. Class I instruments should have a minimum detectable leak rate of 6.7 × 10−7 mol/s (1.5 × 10−2 std. cm3/s at 0°C) or more for the pressure method of gas leakage to atmosphere. Class II instruments should have a minimal detectable leak rate of 6.7 × 10−6 mol/s (1.5 × 10−1 std. cm3/s at 0°C) or more for the pressure method of gas leakage to atmosphere. Refer to Guide E432 for additional information. 1.3 Practice B, Ultrasonic Transmitter—For object under test not capable of being pressurized but capable of having ultrasonic tone placed/injected into the test area to act as an ultrasonic leak trace source. 1.3.1 This practice is limited to leaks producing leaka...

  15. Encasement pressurization after leaks in primary piping

    International Nuclear Information System (INIS)

    Preliminary evaluations of existing tank farm waste transfer system encasement piping pressure response to flowing waste supernate following a large primary line leak indicate the potential to exceed current design conditions for the encasement piping system. The potential impact to design of the encasement piping systems is assessed in this paper. Based on the encasement pressure conditions reported, the existing encasement piping systems can perform their safety functions and are capable of withstanding the worst predicted pressure conditions for a large leak in the primary system. Testing is being conducted to validate parameters used in the completed preliminary supernate evaluations and to establish a basis for evaluation of slurry transfer leaks. The results of these tests will be incorporated into the evaluations after results become available. This report provides the current status of encasement pressure analyses to determine suitable conditions for design of encasement piping within the tank farms waste transfer systems. This report provides results of preliminary evaluations, activities necessary to complete the evaluations, potential impacts on existing piping systems, and demonstration of adequacy of the existing encasement piping for withstanding higher pressure than the current design pressure without jeopardizing the safety function of the encasement piping systems to direct the flow of leaked waste from the primary line to a waste transfer-associated structure for detection (i.e., the encasement will direct waste to a pit leak detector before there is any significant release of waste to the environment)

  16. Biomedical applications of capillary electrophoresis

    Science.gov (United States)

    Kartsova, L. A.; Bessonova, E. A.

    2015-08-01

    The review deals with modern analytical approaches used in capillary electrophoresis for solving medical and biological problems: search for biomarkers of various diseases and rapid diagnosis based on characteristic profiles of biologically active compounds by capillary electrophoresis with mass spectrometric detection; monitoring of the residual drugs in biological fluids for evaluating the efficiency of drug therapy; testing of the enantiomeric purity of pharmaceutical products; the use of novel materials as components of stationary and pseudo-stationary phases in capillary electrophoresis and capillary electrochromatography to increase the selectivity of separation of components of complex matrices; and identification of various on-line preconcentration techniques to reduce the detection limits of biologically active analytes. A topical trend in capillary electrophoresis required in clinical practice, viz., the design of microfluidic systems, is discussed. The bibliography includes 173 references.

  17. Capillary optics for radiation focusing

    International Nuclear Information System (INIS)

    Capillary lens technology may ultimately bring benefits to neutron and x-ray-based science like conventional lenses with visible light. Although the technology is not yet 10 years old, these lenses have already had a significant impact in engineering, science, and medicine. Capillary lenses are advantageous when it is desirable to increase the radiation flux at a location without regard to its angular divergence. PNNL has worked to improve the technology in several ways. A single, optimally tapered capillary was manufactured, which allows intensity gains of a factor of 270 for an initially parallel, incident x-ray beam. Feasibility of constructing neutron lenses using 58Ni (particularly effective at reflecting neutrons) has been explored. Three applications for capillary optics have been identified and studied: neutron telescope, Gandolphi x-ray diffractometry, and neutron radiotherapy. A brief guide is given for determining which potential applications are likely to be helped by capillary optics

  18. The Effects of Alcohol Abuse on Pulmonary Alveolar-Capillary Barrier Function in Humans

    OpenAIRE

    Burnham, Ellen L.; Halkar, Raghuveer; Burks, Marsha; Moss, Marc

    2008-01-01

    Aims: Alcohol abuse is associated with the development of the acute respiratory distress syndrome, a disorder characterized by abnormal alveolar-capillary permeability. We hypothesized that individuals with a history of alcohol abuse would have clinical evidence of abnormal alveolar-capillary permeability even in the absence of symptoms. This could contribute to their propensity for the development of this disorder. Methods: Thirty-three subjects with a history of alcohol abuse, but no other ...

  19. Recent Progress in Technology of Leak detection

    International Nuclear Information System (INIS)

    It is very important to check for leakage points of fluids and gases on primary pressure boundary of nuclear power plants in order to maintain and manage various structures safely. Even though much investigation has been performed by a number of researchers, there are a lot of problems to detect the leakage under some areas to which people can not approach. In particular, it is certainly necessary to find the leakage point in order to repair and replace the pressure boundaries. In this report, the basic principle and application situations for the development of the leak detection system which can detect micro-leaks are introduced. As the technologies and performances of recent sensors have been improving, the application range of leak detection has been increasing steadily. Therefore the sensor technologies written in this report will be able to contribute to nuclear safety to detect the leakage rate and the leakage point with an on-line monitoring system in the near future

  20. Recent Progress in Technology of Leak detection

    Energy Technology Data Exchange (ETDEWEB)

    Jung, H. K.; Kim, S. H.; Cho, J. W.; Joo, Y. S.; Yang, D. J

    2005-07-15

    It is very important to check for leakage points of fluids and gases on primary pressure boundary of nuclear power plants in order to maintain and manage various structures safely. Even though much investigation has been performed by a number of researchers, there are a lot of problems to detect the leakage under some areas to which people can not approach. In particular, it is certainly necessary to find the leakage point in order to repair and replace the pressure boundaries. In this report, the basic principle and application situations for the development of the leak detection system which can detect micro-leaks are introduced. As the technologies and performances of recent sensors have been improving, the application range of leak detection has been increasing steadily. Therefore the sensor technologies written in this report will be able to contribute to nuclear safety to detect the leakage rate and the leakage point with an on-line monitoring system in the near future.

  1. Influenza-Induced Priming and Leak of Human Lung Microvascular Endothelium upon Exposure to Staphylococcus aureus.

    Science.gov (United States)

    Wang, Changsen; Armstrong, Susan M; Sugiyama, Michael G; Tabuchi, Arata; Krauszman, Adrienn; Kuebler, Wolfgang M; Mullen, Brendan; Advani, Suzanne; Advani, Andrew; Lee, Warren L

    2015-10-01

    A major cause of death after influenza virus infection is lung injury due to a bacterial superinfection, yet the mechanism is unknown. Death has been attributed to virus-induced immunosuppression and bacterial overgrowth, but this hypothesis is based on data from the preantibiotic era and animal models that omit antimicrobial therapy. Because of diagnostic uncertainty, most patients with influenza receive antibiotics, making bacterial overgrowth unlikely. Respiratory failure after superinfection presents as acute respiratory distress syndrome, a disorder characterized by lung microvascular leak and edema. The objective of this study was to determine whether the influenza virus sensitizes the lung endothelium to leak upon exposure to circulating bacterial-derived molecular patterns from Staphylococcus aureus. In vitro as well as in vivo models of influenza followed by S. aureus superinfection were used. Molecular mechanisms were explored using molecular biology, knockout mice, and human autopsy specimens. Influenza virus infection sensitized human lung endothelium to leak when challenged with S. aureus, even at low doses of influenza and even when the pathogens were given days apart. Influenza virus increased endothelial expression of TNFR1 both in vitro and in intact lungs, a finding corroborated by human autopsy specimens of patients with influenza. Leak was recapitulated with protein A, a TNFR1 ligand, and sequential infection caused protein A-dependent loss of IκB, cleavage of caspases 8 and 3, and lung endothelial apoptosis. Mice infected sequentially with influenza virus and S. aureus developed significantly increased lung edema that was protein A and TNFR1 dependent. Influenza virus primes the lung endothelium to leak, predisposing patients to acute respiratory distress syndrome upon exposure to S. aureus. PMID:25693001

  2. CT assessment of anastomotic bowel leak

    International Nuclear Information System (INIS)

    Aim: To evaluate the predictors of clinically important gastrointestinal anastomotic leaks using multidetector computed tomography (CT). Subjects and methods: Ninety-nine patients, 73 with clinical suspicion of anastomotic bowel leak and 26 non-bowel surgery controls underwent CT to investigate postoperative sepsis. Fifty patients had undergone large bowel and 23 small bowel anastomoses. The time interval from surgery was 3-30 days (mean 10 ± 5.9 SD) for the anastomotic group and 3-40 days (mean 14 ± 11 SD) for the control group (p = 0.3). Two radiologists blinded to the final results reviewed the CT examinations in consensus and recorded the presence of peri-anastomotic air, fluid or combination of the two; distant loculated fluid or combination of fluid and air; free air or fluid; and intestinal contrast leak. Final diagnosis of clinically important anastomotic leak (CIAL) was confirmed at surgery or by chart review of predetermined clinical and laboratory criteria. Results: The prevalence of CIAL in the group undergoing CT was 31.5% (23/73). The CT examinations with documented leak were performed 5-28 (mean; 11.4 ± 6 SD) days after surgery. Nine patients required repeat operation, 10 percutaneous abscess drainage, two percutaneous drainage followed by surgery, and two prolonged antibiotic treatment and total parenteral nutrition (TPN). Of the CT features examined, only peri-anastomotic loculated fluid containing air was more frequently seen in the CIAL group as opposed to the no leak group (p = 0.04). There was no intestinal contrast leakage in this cohort. Free air was present up to 9 days and loculated air up to 26 days without CIAL. Conclusion: Most postoperative CT features overlap between patients with and without CIAL. The only feature seen statistically more frequently with CIAL is peri-anastomotic loculated fluid containing air

  3. CT assessment of anastomotic bowel leak

    Energy Technology Data Exchange (ETDEWEB)

    Power, N. [Department of Radiology, Sunnybrook Hospital, Toronto, Ontario M4N 3M5 (Canada); Atri, M. [Department of Radiology, Sunnybrook Hospital, Toronto, Ontario M4N 3M5 (Canada)]. E-mail: mostafa.atri@sw.ca; Ryan, S. [Department of Radiology, Sunnybrook Hospital, Toronto, Ontario M4N 3M5 (Canada); Haddad, R. [Department of Surgery, Sunnybrook Hospital, Toronto, Ontario M4N 3M5 (Canada); Smith, A. [Department of Surgery, Sunnybrook Hospital, Toronto, Ontario M4N 3M5 (Canada)

    2007-01-15

    Aim: To evaluate the predictors of clinically important gastrointestinal anastomotic leaks using multidetector computed tomography (CT). Subjects and methods: Ninety-nine patients, 73 with clinical suspicion of anastomotic bowel leak and 26 non-bowel surgery controls underwent CT to investigate postoperative sepsis. Fifty patients had undergone large bowel and 23 small bowel anastomoses. The time interval from surgery was 3-30 days (mean 10 {+-} 5.9 SD) for the anastomotic group and 3-40 days (mean 14 {+-} 11 SD) for the control group (p = 0.3). Two radiologists blinded to the final results reviewed the CT examinations in consensus and recorded the presence of peri-anastomotic air, fluid or combination of the two; distant loculated fluid or combination of fluid and air; free air or fluid; and intestinal contrast leak. Final diagnosis of clinically important anastomotic leak (CIAL) was confirmed at surgery or by chart review of predetermined clinical and laboratory criteria. Results: The prevalence of CIAL in the group undergoing CT was 31.5% (23/73). The CT examinations with documented leak were performed 5-28 (mean; 11.4 {+-} 6 SD) days after surgery. Nine patients required repeat operation, 10 percutaneous abscess drainage, two percutaneous drainage followed by surgery, and two prolonged antibiotic treatment and total parenteral nutrition (TPN). Of the CT features examined, only peri-anastomotic loculated fluid containing air was more frequently seen in the CIAL group as opposed to the no leak group (p = 0.04). There was no intestinal contrast leakage in this cohort. Free air was present up to 9 days and loculated air up to 26 days without CIAL. Conclusion: Most postoperative CT features overlap between patients with and without CIAL. The only feature seen statistically more frequently with CIAL is peri-anastomotic loculated fluid containing air.

  4. Advances in capillary electrophoresis

    International Nuclear Information System (INIS)

    In the 1980s, capillary electrophoresis (CE) developed rapidly into a first-class analytical separation technique. Its advances in instru-mentation and method development will not only enhance or complement existing mature separation techniques such as liquid chromatography and conventional slab gel electrophoresis, but will also severely challenge these separation methods. A brief overview of most striking achievement of CE in the 1980s is given, which illustrates the challenge to liquid chromatography and conventional slab gel electrophoresis, and some detailed discussions are presented to highlight the advantages of CE. New developments in CE that can be expected for the 1990s include especially column technology, separation chemistry and instrumentation, which will serve further to diversify and improve the applicability of this technique in areas which are poorly addressed by other separation methods. This paper considers and speculates on the technological advancements that can be expected to emerge for CE in the 1990s. (author). 95 refs.; 14 figs

  5. Laser Schlieren System Detects Sounds Of Leaks

    Science.gov (United States)

    Shakkottai, Parthasarathy P.; Alwar, A. Vijayaragavan

    1990-01-01

    Hostile environments monitored safely and noninvasively. Modified laser schlieren system acts as microphone to detect sounds of leaks remotely. Sensitive to acoustical frequencies above audible range and especially suited for monitoring leaks of high-pressure steam from boilers or chemical vapors from processing equipment. Does not require placement of delicate equipment in harsh environment monitored, and no contact needed with boiler or other unit being monitored. Detects sound waves via variation of index of refraction of air at acoustical frequencies. Used to monitor sound frequencies beyond range of human hearing.

  6. Hydrogen detection systems leak response codes

    International Nuclear Information System (INIS)

    A loss in tightness of a water tube inside a Steam Generator Unit of a Fast Reactor is usually monitored by hydrogen detection systems. Such systems have demonstrated in the past their ability to detect a leak in a SGU. However, the increase in size of the SGU or the choice of ferritic material entails improvement of these systems in order to avoid secondary leak or to limit damages to the tube bundle. The R and D undertaken in France on this subject is presented. (author). 11 refs, 10 figs

  7. Single-Shell Tank Leak Integrity Summary

    Energy Technology Data Exchange (ETDEWEB)

    Harlow, D. G.; Girardot, C. L.; Venetz, T. J.

    2015-03-26

    This document summarizes and evaluates the information in the Hanford Tri-Party Agreement Interim Milestone M-045-91F Targets completed between 2010 and 2015. 1) Common factors of SST liner failures (M-045-91F-T02), 2) the feasibility of testing for ionic conductivity between the inside and outside of SSTs (M-045-91F-T03, and 3) the causes, locations, and rates of leaks from leaking SSTs (M-045-91F-T04).

  8. The sodium-leak channel, NALCN, in health and disease

    Directory of Open Access Journals (Sweden)

    Maud eCochet-Bissuel

    2014-05-01

    Full Text Available Ion channels are crucial components of cellular excitability and are involved in many neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors (GPCRs-activated NALCN channel that is predominantly expressed in neurons where it regulates the resting membrane potential and neuronal excitability. NALCN is part of a complex that includes not only GPCRs, but also UNC-79, UNC-80, NLF-1 and src family of Tyrosine kinases (SFKs. There is growing evidence that the NALCN channelosome critically regulates its ion conduction. Both in mammals and invertebrates, animal models revealed an involvement in many processes such as locomotor behaviours, sensitivity to volatile anesthetics, and respiratory rhythms. There is also evidence that alteration in this NALCN channelosome can cause a wide variety of diseases. Indeed, mutations in the NALCN gene were identified in Infantile Neuroaxonal Dystrophy (INAD patients, as well as in patients with an Autosomal Recessive Syndrome with severe hypotonia, speech impairment, and cognitive delay. Deletions in NALCN gene were also reported in diseases such as 13q syndrome. In addition, genes encoding NALCN, NLF- 1, UNC-79 and UNC-80 proteins may be susceptibility loci for several diseases including bipolar disorder, schizophrenia, Alzheimer’s disease, autism, epilepsy, alcoholism, cardiac diseases and cancer. Although the physiological role of the NALCN channelosome is poorly understood, its involvement in human diseases should foster interest for drug development in the near future. Towards this goal, we review here the current knowledge on the NALCN channelosome in physiology and diseases.

  9. Arrangement for the electronic ultrasonic leak testing

    International Nuclear Information System (INIS)

    The electronic equipment serves to receive ultrasonic signals, originated by a fluid (for example He) that under high pressure flows out of an opening (box cap-leak testing method). The ultrasonic signal is received by a microphone, amplified, and then led to an average signal value circuit, which together with a logic circuit locates the failed boxes. (DG)

  10. Locating Small Leaks in Large Structures

    Science.gov (United States)

    Lawler, W. F.

    1983-01-01

    Test tool for detecting minute leads in bimetal joints, welds, or other locations employs fine-control valve and hypodermic needle. Test item is connected in conventional manner to helium mass spectrometer tuned to read extremely small amounts of helium gas. Uniqueness of method is ability to detect tiny leaks, through surfaces, not discoverable by gross coverage of test structures by helium gas.

  11. Analysis of Capillary Rise in Asymmetric Branch-Like Capillary

    Science.gov (United States)

    Li, Caoxiong; Shen, Yinghao; Ge, Hongkui; Yang, Zhihui; Su, Shuai; Ren, Kai; Huang, Heyu

    2016-05-01

    Transport in porous media is common in nature, attracting many attentions for a long time. Tree-like network model is often used as a simplification for porous space, expressing the complexity of pore spaces instead of capillary bundle. To investigate spontaneous imbibition characteristics in this network, a dynamic asymmetric branch-like capillary model is used to represent basic network structure, using fractal method to represent tortuosity. This work investigates the influence of parameters on imbibition process in the branch-like capillary model. An analytical equation for the imbibition mass versus time is derived. Parameters from capillary structures to liquid properties are taken into account and analyzed based on the numerical solution of the equation. It is found that the imbibition process in asymmetric branch-like capillary model can be recognized by four sections and brunching tubes are positive for imbibition process. Concomitantly, meniscus arrest event is simulated and discussed. Moreover, the influence of parameters on imbibition process is discussed. These parameters can be classified as static and dynamic. Static parameters mainly change the capillary force, which are related to the ultimate imbibition mass or imbibition ability, while dynamic parameters mainly have influence on resistance of flowing fluid, which are related to the imbibition speed in the imbibition process.

  12. The effect of contact angles and capillary dimensions on the burst frequency of super hydrophilic and hydrophilic centrifugal microfluidic platforms, a CFD study.

    Science.gov (United States)

    Kazemzadeh, Amin; Ganesan, Poo; Ibrahim, Fatimah; He, Shuisheng; Madou, Marc J

    2013-01-01

    This paper employs the volume of fluid (VOF) method to numerically investigate the effect of the width, height, and contact angles on burst frequencies of super hydrophilic and hydrophilic capillary valves in centrifugal microfluidic systems. Existing experimental results in the literature have been used to validate the implementation of the numerical method. The performance of capillary valves in the rectangular and the circular microfluidic structures on super hydrophilic centrifugal microfluidic platforms is studied. The numerical results are also compared with the existing theoretical models and the differences are discussed. Our experimental and computed results show a minimum burst frequency occurring at square capillaries and this result is useful for designing and developing more sophisticated networks of capillary valves. It also predicts that in super hydrophilic microfluidics, the fluid leaks consistently from the capillary valve at low pressures which can disrupt the biomedical procedures in centrifugal microfluidic platforms. PMID:24069169

  13. The effect of contact angles and capillary dimensions on the burst frequency of super hydrophilic and hydrophilic centrifugal microfluidic platforms, a CFD study.

    Directory of Open Access Journals (Sweden)

    Amin Kazemzadeh

    Full Text Available This paper employs the volume of fluid (VOF method to numerically investigate the effect of the width, height, and contact angles on burst frequencies of super hydrophilic and hydrophilic capillary valves in centrifugal microfluidic systems. Existing experimental results in the literature have been used to validate the implementation of the numerical method. The performance of capillary valves in the rectangular and the circular microfluidic structures on super hydrophilic centrifugal microfluidic platforms is studied. The numerical results are also compared with the existing theoretical models and the differences are discussed. Our experimental and computed results show a minimum burst frequency occurring at square capillaries and this result is useful for designing and developing more sophisticated networks of capillary valves. It also predicts that in super hydrophilic microfluidics, the fluid leaks consistently from the capillary valve at low pressures which can disrupt the biomedical procedures in centrifugal microfluidic platforms.

  14. Stress failure of pulmonary capillaries: role in lung and heart disease

    Science.gov (United States)

    West, J. B.; Mathieu-Costello, O.

    1992-01-01

    Pulmonary capillaries have extremely thin walls to allow rapid exchange of respiratory gases across them. Recently it has been shown that the wall stresses become very large when the capillary pressure is raised, and in anaesthetised rabbits, ultrastructural damage to the walls is seen at pressures of 40 mm Hg and above. The changes include breaks in the capillary endothelial layer, alveolar epithelial layer, and sometimes all layers of the wall. The strength of the thin part of the capillary wall can be attributed to the type IV collagen in the extracellular matrix. Stress failure of pulmonary capillaries results in a high-permeability form of oedema, or even frank haemorrhage, and is apparently the mechanism of neurogenic pulmonary oedema and high-altitude pulmonary oedema. It also explains the exercise-induced pulmonary haemorrhage that occurs in all racehorses. Several features of mitral stenosis are consistent with stress failure. Overinflation of the lung also leads to stress failure, a common cause of increased capillary permeability in the intensive care environment. Stress failure also occurs if the type IV collagen of the capillary wall is weakened by autoantibodies as in Goodpasture's syndrome. Neutrophil elastase degrades type IV collagen and this may be the starting point of the breakdown of alveolar walls that is characteristic of emphysema. Stress failure of pulmonary capillaries is a hitherto overlooked and potentially important factor in lung and heart disease.

  15. Developments in steam generator leak detection at Ontario Hydro

    International Nuclear Information System (INIS)

    A method for locating small tube leaks in steam generators has been developed and implemented at Ontario Hydro. The technique utilizes both helium leak detection and moisture leak detection. The combination of these two methods allows tube leaks to be detected in any part of the tube bundle, including those submerged below water near the tubesheet. The estimated detection limits for the helium and moisture leak detection systems are 0.001 kg/hr and 0.05 kg/hr respectively, expressed as leak rates measured at typical boiler operating conditions. This technology is best utilized in situations where the leak rate under operating conditions is smaller than the practical limit for fluorescein dye techniques (∼2 kg/hour). Other novel techniques have been utilized to increase the reliability and speed of the boiler leak search process. These include the use of argon carrier gas to stabilize the buoyant helium gas in the boiler secondary. (author)

  16. Experiments and calculations to leak openings and leak rates on typical piping components and systems

    International Nuclear Information System (INIS)

    Calculations of leak opening and leak rate for through cracks in piping components have been performed. The analyses are pre- or mostly post-calculations to experiments performed at the HDR facility under PWR operating conditions. Piping components under consideration are small diameter straight pipes with circumferential cracks, pipe bends with longitudinal or circumferential cracks and pipe branches with weldment cracks. The component are loaded by internal pressure and opening as well as closing bending moment. The finite element method and two-phase flow leak rate programs are used for the calculations. Results of the analyses are presented as J-integral values, crack opening displacements and areas and leak rates as well as comparisons to the experimental results. 6 refs., 16 figs., 2 tabs

  17. Development of online leak rate evaluation method for various leak phenomena in NPPs

    International Nuclear Information System (INIS)

    There are various leak phenomena in nuclear power plants, such as thermal or vibration fatigue crack, grand of valve, valve sheet, mechanical seal and SG tubes, and so on. In the current power plant, engineers should find such problems by annual inspection. But, in case of severe accident, operators should conduct a prompt action without mistake. It is very difficult to do such action with limited information and AM tools. Therefore, authors have conducted to develop online leak rate evaluation method for such various leak phenomena. The system will notice such troublesome by a robotics image on a large screen. The system has a knowledge base evaluation system by using a plant simulator with reactor physics and thermal hydraulics models, and this system advice operator to have an action with guidelines information. In this paper, leak rate evaluation method is shown based on the NUCIA trouble data of actual NPPs. (author)

  18. Modeling leaks from liquid hydrogen storage systems.

    Energy Technology Data Exchange (ETDEWEB)

    Winters, William Stanley, Jr.

    2009-01-01

    This report documents a series of models for describing intended and unintended discharges from liquid hydrogen storage systems. Typically these systems store hydrogen in the saturated state at approximately five to ten atmospheres. Some of models discussed here are equilibrium-based models that make use of the NIST thermodynamic models to specify the states of multiphase hydrogen and air-hydrogen mixtures. Two types of discharges are considered: slow leaks where hydrogen enters the ambient at atmospheric pressure and fast leaks where the hydrogen flow is usually choked and expands into the ambient through an underexpanded jet. In order to avoid the complexities of supersonic flow, a single Mach disk model is proposed for fast leaks that are choked. The velocity and state of hydrogen downstream of the Mach disk leads to a more tractable subsonic boundary condition. However, the hydrogen temperature exiting all leaks (fast or slow, from saturated liquid or saturated vapor) is approximately 20.4 K. At these temperatures, any entrained air would likely condense or even freeze leading to an air-hydrogen mixture that cannot be characterized by the REFPROP subroutines. For this reason a plug flow entrainment model is proposed to treat a short zone of initial entrainment and heating. The model predicts the quantity of entrained air required to bring the air-hydrogen mixture to a temperature of approximately 65 K at one atmosphere. At this temperature the mixture can be treated as a mixture of ideal gases and is much more amenable to modeling with Gaussian entrainment models and CFD codes. A Gaussian entrainment model is formulated to predict the trajectory and properties of a cold hydrogen jet leaking into ambient air. The model shows that similarity between two jets depends on the densimetric Froude number, density ratio and initial hydrogen concentration.

  19. Surface Tension and Capillary Rise

    Science.gov (United States)

    Walton, Alan J.

    1972-01-01

    Discussion of the shortcomings of textbook explanations of surface tension, distinguishing between concepts of tension and capillary rise. The arguments require only a clear understanding of Newtonian mechanics, notably potential energy. (DF)

  20. Capillary Condensation in Confined Media

    CERN Document Server

    Charlaix, Elisabeth

    2009-01-01

    We review here the physics of capillary condensation of liquids in confined media, with a special regard to the application in nanotechnologies. The thermodynamics of capillary condensation and thin film adsorption are first exposed along with all the relevant notions. The focus is then shifted to the modelling of capillary forces, to their measurements techniques (including SFA, AFM and crack tips) and to their influence on AFM imaging techniques as well as on the static and dynamic friction properties of solids (including granular heaps and sliding nanocontacts). A great attention is spent in investigating the delicate role of the surface roughness and all the difficulties involved in the reduction of the probe size to nanometric dimensions. Another major consequence of capillary condensation in nanosystems is the activation of several chemical and corrosive processes that can significantly alter the surface properties, such as dissolution/redeposition of solid materials and stress-corrosion crack propagati...

  1. Capillary electrophoresis electrospray ionization mass spectrometry interface

    Science.gov (United States)

    Smith, Richard D.; Severs, Joanne C.

    1999-01-01

    The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an anolyte sample from a capillary electrophoresis separation capillary to a electrospray ionization mass spectrometry emitter capillary. The interface of the present invention has: (a) a charge transfer fitting enclosing both of the capillary electrophoresis capillary end and the electrospray ionization mass spectrometry emitter capillary end; (b) a reservoir containing an electrolyte surrounding the charge transfer fitting; and (c) an electrode immersed into the electrolyte, the electrode closing a capillary electrophoresis circuit and providing charge transfer across the charge transfer fitting while avoiding substantial bulk fluid transfer across the charge transfer fitting. Advantages of the present invention have been demonstrated as effective in providing high sensitivity and efficient analyses.

  2. Dynamic pressure measures for long pipeline leak detection

    Energy Technology Data Exchange (ETDEWEB)

    Likun Wang; Hongchao Wang; Min Xiong; Bin Xu; Dongjie Tan; Hengzhang Zhou [PetroChina Pipeline Company, Langfang (China). R and D Center

    2009-07-01

    Pipeline leak detection method based on dynamic pressure is studied. The feature of dynamic pressure which is generated by the leakage of pipeline is analyzed. The dynamic pressure method is compared with the static pressure method for the advantages and disadvantages in pipeline leak detection. The dynamic pressure signal is suitable for pipeline leak detection for quick-change of pipeline internal pressure. Field tests show that the dynamic pressure method detects pipeline leak rapidly and precisely. (author)

  3. Experiences with leak rate calculations methods for LBB application

    Energy Technology Data Exchange (ETDEWEB)

    Grebner, H.; Kastner, W.; Hoefler, A.; Maussner, G. [and others

    1997-04-01

    In this paper, three leak rate computer programs for the application of leak before break analysis are described and compared. The programs are compared to each other and to results of an HDR Reactor experiment and two real crack cases. The programs analyzed are PIPELEAK, FLORA, and PICEP. Generally, the different leak rate models are in agreement. To obtain reasonable agreement between measured and calculated leak rates, it was necessary to also use data from detailed crack investigations.

  4. Double Shell Tank AY-102 Radioactive Waste Leak Investigation

    Energy Technology Data Exchange (ETDEWEB)

    Washenfelder, Dennis J.

    2014-04-10

    PowerPoint. The objectives of this presentation are to: Describe Effort to Determine Whether Tank AY-102 Leaked; Review Probable Causes of the Tank AY-102 Leak; and, Discuss Influence of Leak on Hanford’s Double-Shell Tank Integrity Program.

  5. 1999 Leak Detection, Monitoring, and Mitigation Strategy Update

    International Nuclear Information System (INIS)

    This document is a complete revision of WHC-SD-WM-ES-378, Rev 1. This update includes recent developments in Leak Detection, Leak Monitoring, and Leak Mitigation technologies, as well as, recent developments in single-shell tank retrieval technologies. In addition, a single-shell tank retrieval release protection strategy is presented

  6. Final evaluation of advanced and current leak detection systems

    International Nuclear Information System (INIS)

    This report presents the results of a study to evaluate the adequacy of leak detection systems in light water reactors. The sources of numerous reported leaks and methods of detection have been documented. Research to advance the state of the art of acoustic leak detection is presented, and procedures for implementation are discussed

  7. 49 CFR 230.64 - Leaks under lagging.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Boilers and Appurtenances Steam Leaks § 230.64 Leaks under lagging. The steam locomotive owner and/or operator shall take out of service at once any boiler that has developed a leak under the lagging due to a crack in the shell, or...

  8. Acoustic leak detection at complicated topologies using neural netwoks

    International Nuclear Information System (INIS)

    Considering the shortcomings of all the existing leak detecting principles, a new method again based on the measurement of the leak induced sound but also applying pattern recognition is being developed. The capability of neural networks to localize leaks at the reactor pressure vessel (RPV) head of VVER-440 reactors is discussed. (orig./DG)

  9. 1999 Leak Detection and Monitoring and Mitigation Strategy Update

    Energy Technology Data Exchange (ETDEWEB)

    OHL, P.C.

    1999-09-23

    This document is a complete revision of WHC-SD-WM-ES-378, Rev 1. This update includes recent developments in Leak Detection, Leak Monitoring, and Leak Mitigation technologies, as well as, recent developments in single-shell tank retrieval technologies. In addition, a single-shell tank retrieval release protection strategy is presented.

  10. Application of acoustic leak detection technology for the detection and location of leaks in light water reactors

    International Nuclear Information System (INIS)

    This report presents the results of a study to evaluate the adequacy of leak detection systems in light water reactors. The sources of numerous reported leaks and methods of detection have been documented. Research to advance the state of the art of acoustic leak detection is presented, and procedures for implementation are discussed. 14 refs., 70 figs., 10 tabs

  11. Leak Detection in Offshore Pipelines of Conveying Fluid

    Institute of Scientific and Technical Information of China (English)

    李俊花; 崔莉

    2004-01-01

    Leakage from pipelines has caused serious environmental pollution and economic losses. Usually, leak detection can reduce the damage. The paper mainly discusses a hydraulic gradient-based leak detection method. The basic idea is outlined first, followed by a description of a laboratory experiment in a water pipeline. Several pressure curves are established based on different leak locations under the condition of a constant total flow rate. It is demonstrated that the leak of a large leak quantity can be detected reliably by the hydraulic gradient method.

  12. Steam generator leak detection at Bruce A Unit 1

    International Nuclear Information System (INIS)

    A new steam generator leak detection system was recently developed and utilized at Bruce A. The equipment is based on standard helium leak detection, with the addition of moisture detection and several other capability improvements. All but 1% of the Unit 1 Boiler 03 tubesheet was inspected, using a sniffer probe which inspected tubes seven at a time and followed by individual tube inspections. The leak search period was completed in approximately 24 hours, following a prerequisite period of several days. No helium leak indications were found anywhere on the boiler. A single water leak indication was found, which was subsequently confirmed as a through-wall defect by eddy current inspection. (author)

  13. ENRAF annulus leak detector development test

    International Nuclear Information System (INIS)

    ENRAF 854 ATG level detectors are normally used for measuring and tracking waste levels in the Hanford waste tanks. Since instrument technicians and operators are familiar with these gauges, it has been suggested that ENRAF 854's be used to alleviate problems with the existing annulus leak detector devices. The purpose of this test is to determine the following: (1) The liquid level at which the gauge will report a change in level, given the displacer initially resting on the bottom of a container; and (2) Whether the high alarm level can be set at 0.25 inch above the bottom of the container. This test and its results will be applicable to ENRAF 854 ATG level detectors used as annulus leak detectors

  14. Using N-16 to measure leaks

    International Nuclear Information System (INIS)

    An advanced primary to secondary leak rate monitoring system for nuclear power plants is described. Detectors on each steam line measure the activation product N16 and fission products. An in-field RM-2000 microprocessor monitors up to four main steam lines for N16 and fission products. Using the measurements of the N16 present in the secondary coolant and the reactor power level, the processor calculates the leak rate from the primary side of the steam generator to the secondary side. The fission product detector is designed to respond to gamma dose rates from iodine and noble gases associated with a major primary to secondary ingress. The microprocessor provides a direct digital display which is also transmitted to the plant's main computer and to an RM-2300 control/display module in the control room. The system's multichannel architecture and modern electronics, minimise the cost of installation and maintenance. (UK)

  15. Compartment Syndrome Resulting from Carbon Monoxide Poisoning.

    Science.gov (United States)

    Serbest, Sancar; Belhan, Oktay; Gürger, Murat; Tosun, Haci Bayram

    2015-12-01

    Every year, especially in the cooler Fall and Winter months, hundreds of people die because of carbon monoxide poisoning. This occurs usually as an accident. It is a significant cause of poisoning worldwide. We present a case of compartment syndrome in both lower extremities with accompanying acute renal failure and systemic capillary leakage syndrome because of carbon monoxide poisoning. PMID:26588033

  16. Klippel-Trenaunay Syndrome - A Case Report

    OpenAIRE

    Anju kapoor, Dipankar Sarkar, *Garjesh Singh Rai, **Shweta Anand

    2012-01-01

    Klippel-Trenaunay Syndrome (KTS) is a sporadic disorder characterized by the triad of vascular malformation (capillary hemangioma or port wine stain), venous varicosity and soft tissue and/ or bony hypertrophy. We report here a case of Klippel-Trenaunay syndrome with review of literature.

  17. Telescope sipping - pinpointing leaking fuel bundles

    International Nuclear Information System (INIS)

    Given the top priority operators of nuclear power plants assign to safety, even the slightest sign of damage to the fuel assemblies has to be carefully monitored and analyzed. The detection of leaking fuel bundles also plays an important role in ensuring good availability and economy for the plants. ABB Atom has developed a new, highly accurate method, called 'telescope sipping', for identifying defective fuel assemblies. (orig.)

  18. An AEM survey of a leaking landfill

    OpenAIRE

    Beamish, D

    2005-01-01

    This study presents results obtained from a remarkably small-scale helicopter airborne electromagnetic (AEM) survey of a closed landfill. The landfill, occupying a former quarry, is situated among shallow, worked-out coal seams (pillar and stall workings) and was located over at least two mineshafts that occupied the quarry floor. The landfill was known to be leaking from an extensive borehole investigation that took place in the 1970’s, when the landfill was active. Redevelopment issues and ...

  19. Probabilistic pipe fracture evaluations for leak-rate-detection applications

    International Nuclear Information System (INIS)

    Regulatory Guide 1.45, open-quotes Reactor Coolant Pressure Boundary Leakage Detection Systems,close quotes was published by the U.S. Nuclear Regulatory Commission (NRC) in May 1973, and provides guidance on leak detection methods and system requirements for Light Water Reactors. Additionally, leak detection limits are specified in plant Technical Specifications and are different for Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs). These leak detection limits are also used in leak-before-break evaluations performed in accordance with Draft Standard Review Plan, Section 3.6.3, open-quotes Leak Before Break Evaluation Proceduresclose quotes where a margin of 10 on the leak detection limit is used in determining the crack size considered in subsequent fracture analyses. This study was requested by the NRC to: (1) evaluate the conditional failure probability for BWR and PWR piping for pipes that were leaking at the allowable leak detection limit, and (2) evaluate the margin of 10 to determine if it was unnecessarily large. A probabilistic approach was undertaken to conduct fracture evaluations of circumferentially cracked pipes for leak-rate-detection applications. Sixteen nuclear piping systems in BWR and PWR plants were analyzed to evaluate conditional failure probability and effects of crack-morphology variability on the current margins used in leak rate detection for leak-before-break

  20. Probabilistic pipe fracture evaluations for leak-rate-detection applications

    Energy Technology Data Exchange (ETDEWEB)

    Rahman, S.; Ghadiali, N.; Paul, D.; Wilkowski, G. [Battelle, Columbus, OH (United States)

    1995-04-01

    Regulatory Guide 1.45, {open_quotes}Reactor Coolant Pressure Boundary Leakage Detection Systems,{close_quotes} was published by the U.S. Nuclear Regulatory Commission (NRC) in May 1973, and provides guidance on leak detection methods and system requirements for Light Water Reactors. Additionally, leak detection limits are specified in plant Technical Specifications and are different for Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs). These leak detection limits are also used in leak-before-break evaluations performed in accordance with Draft Standard Review Plan, Section 3.6.3, {open_quotes}Leak Before Break Evaluation Procedures{close_quotes} where a margin of 10 on the leak detection limit is used in determining the crack size considered in subsequent fracture analyses. This study was requested by the NRC to: (1) evaluate the conditional failure probability for BWR and PWR piping for pipes that were leaking at the allowable leak detection limit, and (2) evaluate the margin of 10 to determine if it was unnecessarily large. A probabilistic approach was undertaken to conduct fracture evaluations of circumferentially cracked pipes for leak-rate-detection applications. Sixteen nuclear piping systems in BWR and PWR plants were analyzed to evaluate conditional failure probability and effects of crack-morphology variability on the current margins used in leak rate detection for leak-before-break.

  1. Epidural block and neostigmine cause anastomosis leak

    Directory of Open Access Journals (Sweden)

    Ataro G

    2016-05-01

    Full Text Available Getu Ataro Department of Anesthesia, Jimma University, Jimma, EthiopiaI read the article by Phillips entitled, “Reducing gastrointestinal anastomotic leak rates: review of challenges and solutions”, published in the journal of Open Access Surgery with enthusiasm and found it crucial for perioperative management of patients with gastrointestinal (GI surgery, particularly anastomosis. I appreciate the author’s exhaustive search of literature and discussion with some limitation on review basics like methodology, which may affect the reliability of the review findings. The effects of risk factors for anastomosis leak, such as malnutrition, smoking, steroid use, bowel preparation, chemotherapy, duration of surgery, use of pressors, intravenous fluid administration, blood transfusion, and surgical anastomotic technique, were well discussed.1 However, from anesthesia perspective, there are some other well-studied risk factors that can affect healing of anastomosis wound and cause anastomosis leak. Among others, the effect of neostigmine and epidural block has been reported in many studies since half a century ago. View the original paper by Phillips

  2. He leak testing of Indus-2 dipole vacuum chambers

    International Nuclear Information System (INIS)

    Full text: Centre for Advanced Technology is developing its second synchrotron radiation source INDUS-2 which is a 2.5 GeV electron storage ring. Dipole vacuum chambers are the vital components of Indus-2 vacuum system. Each of these chambers is approx. 3.6 m long and 0.67 m wide with 24 nos. of ports of various sizes. The dipole chambers were made by machining two halves and they are then lip welded together. The dipole chamber has approx. 14 m of total weld length and it was leak tested for leak tightness of the order of 10-10 mbar 1/s. Helium mass spectrometer leak detector (HMSLD) was utilized for the leak testing. Subsequently the leaks of various orders in welding joints were repaired and leak tightness achieved. This paper describes the experiences during leak testing of 20 nos. of aluminum dipole chambers for INDUS-2

  3. Laser-based capillary polarimeter.

    Science.gov (United States)

    Swinney, K; Hankins, J; Bornhop, D J

    1999-01-01

    A laser-based capillary polarimeter has been configured to allow for the detection of optically active molecules in capillary tubes with a characteristic inner diameter of 250 microm and a 39-nL (10(-9)) sample volume. The simple optical configuration consists of a HeNe laser, polarizing optic, fused-silica capillary, and charge-coupled device (CCD) camera in communication with a laser beam analyzer. The capillary scale polarimeter is based on the interaction between a polarized laser beam and a capillary tube, which results in a 360 degree fan of scattered light. This array of scattered light contains a set of interference fringe, which respond in a reproducible manner to changes in solute optical activity. The polarimetric utility of the instrument will be demonstrated by the analysis of two optically active solutes, R-mandelic acid and D-glucose, in addition to the nonoptically active control, glycerol. The polarimetric response of the system is quantifiable with detection limits facilitating 1.7 x 10(-3) M or 68 x 10(-12) nmol (7 psi 10(-9) g) sensitivity. PMID:11315158

  4. Evaluation of advanced and current leak detection systems

    International Nuclear Information System (INIS)

    Differences between PWRs and BWRs with regard to leak detection have now been analyzed. With regard to detection methods, the greatest differences between reactor types are as follows: (a) the sump pump is reported as the detection method more frequently in BWRs than in PWRs (64% vs. 35%); (b) the radiation monitor is reported as the detection method (excluding false alarms) more frequently in PWRs. Current efforts at Argonne National Laboratory (ANL) to evaluate advanced acoustic leak detection methods are directed toward the generation and analysis of acoustic data from large (0.5 to 10 gal/min) leaks and modification of the software of the GARD/ANL advanced acoustic leak detection system. In order to reach the goal of 10 gal/min leaks, the Steam Generator Test Facility at ANL has been modified to carry out the leak testing. Tests were carried out with water at 5250F and 1100 psi leaking through a fatigue crack in a 4-in. schedule 80 pipe. The crack opening can be varied and was set to generate 0.6- to 8.5-gal/min leaks. Acoustic signals were analyzed with respect to rms values, frequency content, and cross-correlation functions. The GARD/ANL advanced acoustic leak detection system software has been modified to permit intelligent continuous acoustic leak monitoring of reactor components. In the monitor mode the computer continually evaluates the rms signal output of acoustic leak detection sensors placed on the primary circuit. If a leak is suspected, acoustic signals are captured and analyzed to determine the source of the leak, the location and estimated leak rate

  5. Single rod leak detection and repair of leaking or damaged fuel assemblies

    International Nuclear Information System (INIS)

    In some circumstances, it is necessary to perform rework operations on some fuel assemblies in order to make them reusable in reactors, movable, transportable or consistent with fuel reprocessor specifications, depending on the plant utility policy. These rework operations are of two types: - Those which consist in restoring the leak tightness of the fuel assemblies. They are made after a series of tests allowing the localization of the failed fuel rods: at first, overall leak detection is provided by monitoring primary coolant activity during reactor operation; then, during refuelling, leaking assemblies are identified by subjecting each of the assemblies scheduled for reloading to a sipping test; finally individual leaking fuel rods are singled out before the defective assemblies can be repaired, i.e. failed rods can be replaced. - Those which involve replacement of part of or the whole assembly structure (combined or not with replacement of failed fuel rods). In order to meet these two needs for rework operations, FRAGEMA has developed a full range of test and tooling systems for detecting single leaking rods in irradiated fuel assemblies and for restoring fuel assemblies to be used in PWR nuclear power plants. As an illustration of the means available, two of these systems are described

  6. The detection of leaks on sodium pipes in a 'leak before break' approach

    International Nuclear Information System (INIS)

    The operation of circuits containing liquid sodium requires, given the chemical affinity of this fluid for air and water, a reliable detection of possible leaks. This system of detection should alert the operators to the occurrence of a leak in sufficient time to limit the potential consequences of a discharge of sodium in the building, leading to a severe sodium fire or at least to an extended corrosion of the pipe system. From a design point of view, the most likely event leading to this situation can be the consequence. of an initial undetected defect which develops under the effect of thermo-mechanical loadings, produces a sodium. leak below the dejection threshold remains undetectable white progressing and finally leads to a guillotine-type rupture when an incidental loading is superimposed to the normal one. The 'leak before break' approach which is now currently introduced in design considerations consists of insuring the detection of incipient leaks corresponding to through-the-wall cracks well below instability of the pipe. Under this short statement, lies a considerable and still necessary effort of research broadly presented in the present paper

  7. Impacts on oil recovery from capillary pressure and capillary heterogeneities

    Energy Technology Data Exchange (ETDEWEB)

    Bognoe, Thomas

    2008-07-01

    The main conclusions drawn from this thesis are; 7 scientific papers are published on a broad variety of subjects, and describes in detail the experiments and research treated in this thesis. Scientific research has been performed, investigating the subjects of capillary pressure and capillary heterogeneities from different angles. This thesis discusses the findings in this study and aims to illustrate the benefits of the results obtained for further development of other experiments, and/or even the industrial benefits in field development. The methods for wettability alteration have developed throughout the work. From producing heterogeneous wettability alterations, the methods have improved to giving both radial and lateral uniform wettability alterations, which also remains unaltered throughout the duration of the experimental work. The alteration of wettability is dependent on initial water saturation, flow rate, aging time and crude oil composition. Capillary pressure and relative permeability curves have been measured for core plugs at different wettabilities using conventional centrifuge methods. The trends observed are mostly consistent with theory. The production mechanisms of strongly and moderately water wet chalk has been investigated. At strongly water wet conditions in fractured chalk; the flow is governed by capillary forces, showing strong impact from the fractures. At moderately water wet conditions, the impact of the fractures are absent, and a dispersed water front is observed during the displacement. The oil recovery is about the same, at the two wettabilities. Fracture crossing mechanisms at the same wettability conditions have been mapped. And the observations are consistent with those of the water floods. During strongly water wet displacement, the fracture crossing is occurring once the inlet core has reached endpoint of spontaneous imbibition. At moderately water wet conditions the fracture crossing is less abrupt, and creation of wetting

  8. Non-Aqueous Capillary Electrophoresis

    Science.gov (United States)

    Szumski, Michał; Buszewski, Bogusław

    Non-aqueous capillary electrophoresis and capillary electrochromatography are special variants of these techniques. Here, organic solvents or their mixtures with or without dissolved electrolytes are used as separation buffer or mobile phase, respectively. The most important features of non-aqueous systems are: better solubility of more hydrophobic ionic substances (many natural products) than in water, much less current and Joule heating allows for using highly concentrated buffers and/or larger capillary internal diameters, polar interactions are enhanced in organic solvents which is often highly advantageous in chiral separation systems. This chapter presents most frequently used solvents, their properties, as well as shows pH* scale which is often used in non-aqueous systems.

  9. Sodium leak at Monju (II): Sodium leak, burning and aerosol behavior

    International Nuclear Information System (INIS)

    The amount of leaked sodium was estimated as approximately 640 kg during the 220 minute leak. The ventilation duct and the walkway grating under the leak site were severely damaged by Na-Fe-O reaction, but the floor liner and the concrete wall were not. A total 100 kg of sodium aerosol was deposited in the reactor auxiliary building and 230 kg was released to the atmosphere. The sodium concentration at the site boundary was calculated as 0.05 mg/m3, NaOH equivalent, which was low in comparison with the permitted level of 2 mg/m3. The tritium quantity released was estimated as 4.4 x 107 Bq, which was about 0.03% of the average released value per month for a LWR. (author)

  10. Evaluation of advanced and current leak detection systems

    International Nuclear Information System (INIS)

    U.S. Nuclear Regulatory Commission Guide 1.45 recommends the use of at least three different detection methods in reactors to detect leakage. Monitoring of both sump-flow and airborne particulate radioactivity is mandatory. A third method can involve either monitoring of condensate flow rate from air coolers or monitoring of airborne gaseous radioactivity. Although the methods currently used for leak detection reflect the state of the art, other techniques may be developed and used. Since the recommendations of Regulatory Guide 1.45 are not mandatory, Licensee Event Report Compilations have been reviewed to help establish actual capabilities for leak detection. The review of event reports, which had previously covered the period of June 1985 to August 1986 has been extended, and now covers events to June 1987. The total number of significant events is now 83. These reports have provided documented, sometimes detailed, summaries of reactor leaks. They have helped establish the capabilities of existing systems to detect and locate leaks. Differences between PWRs and BWRs with regard to leak detection have now been analyzed. With regard to detection methods, the greatest differences between reactor types are as follows: (a) The sump pump is reported as the detection method more frequently in BWRs than in PWRs (64% vs. 35%). (b) The radiation monitor is reported as the detection method (excluding false alarms) more frequently in PWRs. Current efforts at Argonne National Laboratory (ANL) to evaluate advanced acoustic leak detection methods are directed toward the generation and analysis of acoustic data from large (0.5 to 10 gal/min) leaks and modification of the software of the GARD/ANL advanced acoustic leak detection system. In order to reach the goal of 10 gal/min leaks, the Steam Generator Test Facility at ANL has been modified to carry out the leak testing. Tests were carried out with water at 525 deg. F and 1100 psi leaking through a fatigue crack in a 4-in

  11. The experiment and analysis on small leak phenomena

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kyung Chai; Hwang, S. T.; Kim, B. H.; Jeong, J. Y

    2000-07-01

    The liquid sodium which is used as a coolant in LMFBR, may give rise to a serious trouble in the safety aspect of steam generator. The defects in a heat transfer tube, such as pin-hole or tube welding defect, will result in a leakage of high pressure steam into the sodium side and production of hydrogen gas and corrosive sodium compounds which can cause significant damage to the tube wall of steam generator by using exothermic reaction. In significant damage to the tube wall of steam generator by using exothermic reaction. In this case, initial leak size will be enlarged with time and the leak rate developed to large leak through the micro, small, intermediate leaks. Therefore, the analysis of sodium-water reaction phenomena on the micro and small water leaks in the heat transfer tube is very important in the initial leak stage in the aspects of the protection of leak progress and safety evaluation of steam generator. In this study, firstly, the micro and small leaks phenomena, such as reopen size, shape, and time of leak path, self-wastage, corrosion of tube materials, was analyzed from the literature survey and water leakage experiments using the leak specimen. In small water leak experiments, the leak path was plugged by the sodium-water reaction products at the leak path of a specimen, and re-open phenomena were not observed in initial experiments. Other leak experiments, reopen phenomena of self-plugged leak path was observed. Re-open mechanism of sealed path could be explained by the thermal transient and vibration of heat transfer tube. As a result, perfect reopen time of self plugged leak path was observed to be about 130 minutes after water leak initiation. Reopen shape of a specimen was appeared with double layer of circular type, and reopen size of this specimen surface was about 2 mm diameter on sodium side. Also, the corrosion of a specimen initiated from sodium side, the segregation phenomena of Cr in the specimen was found much more than those of

  12. Environmental risk comparisons with internal methods of UST leak detection

    International Nuclear Information System (INIS)

    The past five years have seen a variety of advances in how leaks can be detected from within underground storage tanks. Any leak-detection approach employed within a storage tanks must be conducted at specific time intervals and meet certain leak-rate criteria according to federal and state regulations. Nevertheless, the potential environmental consequences of leak detection approaches differ widely. Internal, volumetric UST monitoring techniques have developed over time including: (1) inventory control with stick measurements, (2) precision tank testing, (3) automatic tank gauging (ATG), (4) statistical inventory reconciliation (SIR), and (5) statistical techniques with automatic tank gauging. An ATG focuses on the advantage of precise data but measured for only a brief period. On the other hand, stick data has less precision but when combined with SIR over extended periods it too can detect low leak rates. Graphs demonstrate the comparable amounts of fuel than can leak out of a tank before being detected by these techniques. The results indicate that annual tank testing has the greatest potential for large volumes of fuel leaking without detection while new statistical approaches with an ATG have the least potential. The environmental implications of the volumes of fuel leaked prior to detection are site specific. For example, if storage tank is surrounded by a high water table and in a sole-source aquifer even small leaks may cause problems. The user must also consider regulatory risks. The level of environmental and regulatory risk should influence selection of the UST leak detection method

  13. [Hepatopulmonary syndrome].

    Science.gov (United States)

    Thévenot, Thierry; Weil, Delphine; Garioud, Armand; Lison, Hortensia; Cadranel, Jean-François; Degano, Bruno

    2016-05-01

    Hepatopulmonary syndrome (HPS) is defined by the association of portal hypertension, increased alveolar-arterial oxygen gradient and intrapulmonary vascular dilations. Pathophysiological mechanisms of hypoxemia are characterized by ventilation-perfusion mismatch, oxygen diffusion limitation between alveolus and the centre of the dilated capillary, and right-to-left shunting. An excess of vasodilator molecules (like nitric monoxide) and proangiogenic factors (like VEGF) play an important role in the occurrence of HPS. Symptoms of HPS are not specific and dominated by a progressive dyspnea in upright position. Pulse oximetry is a simple non-invasive screening test but only detect the most severe forms of HPS. Medical treatment is disappointing and only liver transplantation may lead to resolution of HPS. Survival following liver transplantation is promising when hypoxemia is not severely decreased. PMID:27021476

  14. Chilaiditi Sign on 99mTc-Mebrofenin Hepatobiliary Scan Mimicking Bile Leak in Acute Cholecystitis.

    Science.gov (United States)

    Pascarella, Suzanne; Dadparvar, Simin

    2016-06-01

    Chilaiditi sign is the incidental radiologic finding of intestinal interposition between the liver and diaphragm, whereas Chilaiditi syndrome describes the presence of accompanying clinical symptoms including abdominal pain, constipation, vomiting, and respiratory distress. We describe a case of radiotracer accumulation over the liver dome on Tc-mebrofenin hepatobiliary scan performed on a 72-year-old man with acute cholecystitis mimicking a bile leak. However, chest radiograph and CT revealed intestinal hepatodiaphragmatic interposition. This case illustrates the importance of being familiar with the scintigraphic appearance of the Chilaiditi sign and correlating abnormal nuclear medicine scan findings with other available radiologic modalities. PMID:26859214

  15. Individualized lung recruitment during high-frequency ventilation in preterm infants is not associated with lung hyperinflation and air leaks

    OpenAIRE

    De Jaegere, Anne P; Deurloo, Eline E.; van Rijn, Rick R.; Offringa, Martin; van Kaam, Anton H.

    2016-01-01

    Lung recruitment during high-frequency ventilation (HFV) in preterm infants with respiratory distress syndrome (RDS) has been associated with an increased risk of lung hyperinflation and air leaks. Individualizing the lung recruitment procedure to the severity of lung disease of each patient might reduce these risks. In this prospective cohort study, we evaluated chest X-ray (CXR) characteristics during individualized oxygenation-guided lung recruitment with HFV in preterm infants with RDS, b...

  16. The leak in super heater 2

    International Nuclear Information System (INIS)

    An under sodium leak occurred in Superheater 2 on PFR on 27 February 1987 when the plant was operating on full power. No warning was received by the operators prior to failure of the superheater bursting disc and automatic shut down of the plant. Subsequent examination has shown that 40 tubes suffered damage each equivalent to double ended guillotine failure, with evidence of some damage on a further 70 tubes. This paper reviews the cause of the initial failure and suggests mechanisms which caused further damage

  17. CHINA'S WORST OIL LEAK CLEARED EXPENSIVELY

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Eight days and nights of clean-up efforts after the worst oil leak ever in Chinese waters, the aftermath of a collision between two foreign ships happening at 9:35 pm on December 7 about 8 nautical miles away from the mouth of the Pearl River and near the Danjiang Island, have finally paid off. So far, hundreds of tons of waste oil and polluted water have been cleared up. A large area of oil spills has been cleaned thanks to the prompt and proper operation launched just two hours after the accident.

  18. 340 Facility secondary containment and leak detection

    International Nuclear Information System (INIS)

    This document presents a preliminary safety evaluation for the 340 Facility Secondary Containment and Leak Containment system, Project W-302. Project W-302 will construct Building 340-C which has been designed to replace the current 340 Building and vault tank system for collection of liquid wastes from the Pacific Northwest Laboratory buildings in the 300 Area. This new nuclear facility is Hazard Category 3. The vault tank and related monitoring and control equipment are Safety Class 2 with the remainder of the structure, systems and components as Safety Class 3 or 4

  19. Gas leaks and the greenhouse effect

    International Nuclear Information System (INIS)

    Natural gas is mostly methane, one of the greenhouse gases. Minimizing the amount of gas that leaks from the supply system contributes both to public safety and to reducing the environmental impact of gas supply. Gas use emits lower quantities of carbon dioxide, the main greenhouse gas, than using other fossil fuels, and the gas industry is a relatively minor source of atmospheric methane. British Gas has a continuing programme of replacing older gas mains and lays new mains and transmission pipelines in materials which are less prone to leakage. British Gas is carrying out innovative research to provide the first reliable data on the actual amount of leakage from gas mains. (author)

  20. Capillary thinning of polymeric filaments

    DEFF Research Database (Denmark)

    Kolte, Mette Irene; Szabo, Peter

    1999-01-01

    The capillary thinning of filaments of a Newtonian polybutene fluid and a viscoelastic polyisobutylene solution are analyzed experimentally and by means of numerical simulation. The experimental procedure is as follows. Initially, a liquid sample is placed between two cylindrical plates. Then, th...

  1. Capillary thinning of polymeric filaments

    DEFF Research Database (Denmark)

    Kolte, Mette Irene; Szabo, Peter; Hassager, Ole

    The capillary thinning of a polymeric filament is analysed experimentally as well as by means of numerical simulation. The experimental procedure is as follows. Initially a liquid sample is kept between two cylindrical plates. Then the bottom plate is lowered under gravity to yield a given strain...

  2. Ion guiding in alumina capillaries

    DEFF Research Database (Denmark)

    Juhász, Z.; Sulik, B.; Biri, S.;

    2009-01-01

    Transmission of a few keV impact energy Ne ions through capillaries in anodic alumina membranes has been studied with different ion counting methods using an energy dispersive electrostatic spectrometer, a multichannel plate (MCP) array and sensitive current-measurement. In the present work, we...

  3. Capillary Rise in a Wedge

    Science.gov (United States)

    Piva, M.

    2009-01-01

    In introductory-level physics courses, the concept of surface tension is often illustrated using the example of capillary rise in thin tubes. In this paper the author describes experiments conducted using a planar geometry created with two small plates forming a thin wedge. The distribution of the fluid entering the wedge can be studied as a…

  4. Leak detection and location in MONJU steam generators

    International Nuclear Information System (INIS)

    Leak detection system of MONJU steam generator depends mostly on in-sodium hydrogen detectors. The requirements on leak detector performance are determined from the point of view of protecting tube leak propagation due to wastage, and the process of determining the performance is shown briefly. Research and development activities on in-sodium hydrogen detectors are described and the specifications of leak detectors for MONJU are also presented. In-cover-gas hydrogen detector and acoustic detector are under development. Research and development activities on the leak location after steam generator shutdown by such methods as an electromagnetic method and ultrasonic method are described. The results of the research and development work on inserting the test probes into tubes are described also. An idea for finding the condition of tubes in the neighbourhood of the leak is also presented. (author)

  5. Vacuum leak problem in low energy of pelletron

    International Nuclear Information System (INIS)

    During unit wise conditioning of unit 8, the vacuum started deteriorating inside the tube after a spark. The RGA reading was taken and it was found out that residual gas inside tube was sulphur hexafluoride. A leak was detected in second tube of unit number eight in between electrode 6 to 8. Leak was sealed with the sealant. Again leak check was done and no leak was found. The tank was closed and conditioning was started again. During the same unit number eight conditioning, leak developed again followed by a spark. So the damaged tube was replaced with a new accelerator tube. During the installation time the alignment of the machine was taken care. Again leak checking was done and the tube was baked properly. The tank was closed again and this particular unit was conditioned for about four days. The maximum voltage it has attained was 1.1 MV. (author)

  6. Capillary malformations: a classification using specific names for specific skin disorders.

    Science.gov (United States)

    Happle, R

    2015-12-01

    The name capillary malformation has caused much confusion because it is presently used to designate numerous quite different disorders such as naevus flammeus, the salmon patch, the vascular naevus of the hereditary 'megalencephaly-capillary malformation syndrome' and the skin lesions of non-hereditary traits such as 'capillary malformation-arteriovenous malformation' and 'microcephaly-capillary malformation'. To avoid such bewilderment, the present review describes the distinguishing clinical and genetic criteria of 20 different capillary malformations, and a specific name is given to all of them. The group of capillary naevi includes naevus flammeus, port-wine naevus of the Proteus type, port-wine naevus of the CLOVES type, naevus roseus, rhodoid naevus, cutis marmorata telangiectatica congenita, congenital livedo reticularis, segmental angioma serpiginosum, naevus anaemicus, naevus vascularis mixtus and angiokeratoma circumscriptum. Capillary lesions that perhaps represent naevi are the mesotropic port-wine patch, Carter-Mirzaa macules, unilateral punctate telangiectasia and unilateral naevoid telangiectasia of the patchy type. Capillary malformations that do not represent naevi include X-linked angiokeratoma corporis diffusum (Fabry disease), autosomal dominant angiokeratoma corporis diffusum, hereditary haemorrhagic telangiectasia, hereditary angioma serpiginosusm and the salmon patch. In this way, we are able to discriminate between various non-hereditary capillary naevi such as naevus roseus and the hereditary rhodoid naevus and several hereditary traits that do not represent naevi such as angiokeratoma corporis diffusum and hereditary haemorrhagic telangiectasia; between four different types of port-wine stains, three of them being lateralized and one being mesotropic; between cutis marmorata telangiectatica congenita and congenital livedo reticularis; between telangiectatic naevi and the vasoconstrictive naevus anaemicus; and between two different types of

  7. Leak rate assessment in the leak before break analysis of a PWR piping system

    International Nuclear Information System (INIS)

    In order to validate predictive models used in the L.B.B. (Leak Before Break) procedure for PWR, a cooperation program between CEA, EDF and FRAMATOME is carried out. One item concerns water leak rate assessment through a real fatigue crack under representative thermal hydraulic conditions of a PWR primary loop. In the framework of this cooperation program, experimental tests are carried out at CEA Cadarache. These tests are dedicated to the validation of two-phase flow rate models. For this, a pipe mock up, with a scale factor of two compared to the primary loop, is tested under representative pressure and temperature of 155 bars and 320 Celsius degrees. The real through wall crack is obtained from an initial surface notch pre-cycled under a fatigue loading. The steam flowing out of the pipe from the crack is condensed and weighed to have an experimental measurement of the leak rate. Crack opening area is measured with an optical device coupled to a post processing software. Acoustic gages are also located on the test pipe in order to qualify a detection system based on an acoustic measurement. The aim of the paper is to present the experimental program and results obtained in the first campaign. The validation of a two-phase leak rate model with experimental results is also discussed in this paper, as well as the comparison of crack opening area assessment, as proposed in the L.B.B. procedure, with experimental results. (authors)

  8. Cause Analysis of Gas Leaks and Methods to Limit Leakage

    OpenAIRE

    Svendsen, Christina

    2014-01-01

    Hydrocarbon gas leaks create potential dangerous situations with major accidents representing worst case scenarios. Smaller gas leaks are also unwanted as they represent risk of escalation and often lead to shut down or reduced production. Small gas leaks also represent in total a significant amount of gas which is detrimental to our atmosphere. Gassco supplies about 20 % of the natural gas consumed in Europe. Economic loss is a direct consequence initiated by shutdown or reduced production, ...

  9. Boston Gas tackles leaks with unique drilling rigs

    International Nuclear Information System (INIS)

    This paper reviews a new drilling method and new drilling equipment used to pinpoint gas leaks in urban areas. It describes the drill spacing and drilling time involved in finding such leaks. It discusses the size of the drilling equipment and speed of penetration through various materials, including frozen soils. The use of this equipment has dramatically increased the speed necessary to identify the leak and instigate repairs

  10. Margins in high temperature leak-before-break assessments

    Energy Technology Data Exchange (ETDEWEB)

    Budden, P.J.; Hooton, D.G.

    1997-04-01

    Developments in the defect assessment procedure R6 to include high-temperature mechanisms in Leak-before-Break arguments are described. In particular, the effect of creep on the time available to detect a leak and on the crack opening area, and hence leak rate, is discussed. The competing influence of these two effects is emphasized by an example. The application to Leak-before-Break of the time-dependent failure assessment diagram approach for high temperature defect assessment is then outlined. The approach is shown to be of use in assessing the erosion of margins by creep.

  11. Influenza infects lung microvascular endothelium leading to microvascular leak: role of apoptosis and claudin-5.

    Directory of Open Access Journals (Sweden)

    Susan M Armstrong

    Full Text Available Severe influenza infections are complicated by acute lung injury, a syndrome of pulmonary microvascular leak. The pathogenesis of this complication is unclear. We hypothesized that human influenza could directly infect the lung microvascular endothelium, leading to loss of endothelial barrier function. We infected human lung microvascular endothelium with both clinical and laboratory strains of human influenza. Permeability of endothelial monolayers was assessed by spectrofluorimetry and by measurement of the transendothelial electrical resistance. We determined the molecular mechanisms of flu-induced endothelial permeability and developed a mouse model of severe influenza. We found that both clinical and laboratory strains of human influenza can infect and replicate in human pulmonary microvascular endothelium, leading to a marked increase in permeability. This was caused by apoptosis of the lung endothelium, since inhibition of caspases greatly attenuated influenza-induced endothelial leak. Remarkably, replication-deficient virus also caused a significant degree of endothelial permeability, despite displaying no cytotoxic effects to the endothelium. Instead, replication-deficient virus induced degradation of the tight junction protein claudin-5; the adherens junction protein VE-cadherin and the actin cytoskeleton were unaffected. Over-expression of claudin-5 was sufficient to prevent replication-deficient virus-induced permeability. The barrier-protective agent formoterol was able to markedly attenuate flu-induced leak in association with dose-dependent induction of claudin-5. Finally, mice infected with human influenza developed pulmonary edema that was abrogated by parenteral treatment with formoterol. Thus, we describe two distinct mechanisms by which human influenza can induce pulmonary microvascular leak. Our findings have implications for the pathogenesis and treatment of acute lung injury from severe influenza.

  12. Validation of leak test models for pharmaceutical isolators

    Directory of Open Access Journals (Sweden)

    Shih-Cheng Hu

    2015-04-01

    Full Text Available In this study, we performed three leak tests on a side-recirculated air isolator: a particle-count test, performed at a variety of positive and negative pressures; the SF6 trace gas method, performed at a variety of airflow velocities; and a pressure decay method, performed at a variety of initial pressures. From the particle-count test, we measured particle leak ratios of 30–34% for pressures of −18 to −25 Pa. In contrast, using the SF6 tracer gas method. we measured leak ratios of 7.8%, 5.9%, and 3.8% for airflow velocities of 0.61, 0.51, and 0.41 m/s, respectively. The particle-count test detected leaks quickly and easily, but its leak ratio was overly high because it included particles from outside of the chamber as well as from the filter. Although the SF6 tracer gas method took more time, it was more sensitive and accurate. The leak quantity would be affected by air velocity and the pressure. Leak concentration acted as sterilization phase of isolator that would result in concentration distributed nonhomogeneous phenomena; concentration distributed from outside of the chamber can be acted as a leakage diffusion situation of contaminants leak. Using the pressure decay method to compare downward airflow through a raised-floor and side-wall return air isolators, the fall time, leak quantity, and leak area of the downward airflow through a raised-floor isolator was five times greater, four times les, and 4.5 times less than that of the side-wall return-air isolator, respectively. According to idea gas law, keeping the temperature and pressure of the chamber constant will effectively reduce the leak quantity.

  13. Capillary hemangioma of palatal mucosa

    OpenAIRE

    Bharti, Vipin; Singh, Jagmohan

    2012-01-01

    Hemangiomas are common tumors characterized microscopically by proliferation of blood vessels. The congenital hemangioma is often present at birth and may become more apparent throughout life. They are probably developmental rather than neoplastic in origin. Despite their benign origin and behavior, hemangiomas in the oral cavity are always of clinical importance to the dental profession and require appropriate clinical management. This case report presents a case of capillary hemangioma of a...

  14. Exponential asymptotics and capillary waves

    OpenAIRE

    Chapman, S. J.; Vanden-Broeck, J.

    2002-01-01

    Recently developed techniques in exponential asymptotics beyond all orders are employed on the problem of potential flows with a free surface and small surface tension, in the absence of gravity. Exponentially small capillary waves are found to be generated on the free surface where the equipotentials from singularities in the flow (for example, stagnation points and corners) meet it. The amplitude of these waves is determined, and the implications are considered for many quite general flows....

  15. Nonlinear waves in capillary electrophoresis

    OpenAIRE

    Ghosal, Sandip; Chen, Zhen

    2012-01-01

    Electrophoretic separation of a mixture of chemical species is a fundamental technique of great usefulness in biology, health care and forensics. In capillary electrophoresis the sample migrates in a microcapillary in the presence of a background electrolyte. When the ionic concentration of the sample is sufficiently high, the signal is known to exhibit features reminiscent of nonlinear waves including sharp concentration ‘shocks’. In this paper we consider a simplified model consisting of a ...

  16. Inertial Rise in Short Capillaries

    CERN Document Server

    Shardt, Orest; Derksen, J J; Mitra, Sushanta K

    2013-01-01

    In this fluid dynamics video we show capillary rise experiments with diethyl ether in short tubes. The height of each short tube is less than the maximum height the liquid can achieve, and therefore the liquid reaches the top of the tube while still rising. Over a narrow range of heights, the ether bulges out from the top of the tube and spreads onto the external wall.

  17. 241-AY-102 Leak Detection Pit Drain Line Inspection Report

    Energy Technology Data Exchange (ETDEWEB)

    Boomer, Kayle D. [Washington River Protection Solutions, LLC (United States); Engeman, Jason K. [Washington River Protection Solutions, LLC (United States); Gunter, Jason R. [Washington River Protection Solutions, LLC (United States); Joslyn, Cameron C. [Washington River Protection Solutions, LLC (United States); Vazquez, Brandon J. [Washington River Protection Solutions, LLC (United States); Venetz, Theodore J. [Washington River Protection Solutions, LLC (United States); Garfield, John S. [AEM Consulting (United States)

    2014-01-20

    This document provides a description of the design components, operational approach, and results from the Tank AY-102 leak detection pit drain piping visual inspection. To perform this inspection a custom robotic crawler with a deployment device was designed, built, and operated by IHI Southwest Technologies, Inc. for WRPS to inspect the 6-inch leak detection pit drain line.

  18. 241-AY-102 Leak Detection Pit Drain Line Inspection Report

    International Nuclear Information System (INIS)

    This document provides a description of the design components, operational approach, and results from the Tank AY-102 leak detection pit drain piping visual inspection. To perform this inspection a custom robotic crawler with a deployment device was designed, built, and operated by IHI Southwest Technologies, Inc. for WRPS to inspect the 6-inch leak detection pit drain line

  19. Commercial Grade Item (CGI) Dedication for Leak Detection Relays

    International Nuclear Information System (INIS)

    This Test Plan provides a test method to dedicate the leak detection relays used on the new Pumping Instrumentation and Control (PIC) skids. The new skids are fabricated on-site. The leak detection system is a safety class system per the Authorization Basis

  20. HIGH RESOLUTION RESISTIVITY LEAK DETECTION DATA PROCESSING & EVALUATION MEHTODS & REQUIREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    SCHOFIELD JS

    2007-10-04

    This document has two purposes: {sm_bullet} Describe how data generated by High Resolution REsistivity (HRR) leak detection (LD) systems deployed during single-shell tank (SST) waste retrieval operations are processed and evaluated. {sm_bullet} Provide the basic review requirements for HRR data when Hrr is deployed as a leak detection method during SST waste retrievals.

  1. Strength and leak testing of plasma activated bonded interfaces

    DEFF Research Database (Denmark)

    Visser, M.M.; Weichel, Steen; Reus, Roger De; Hanneborg, A.B.

    detection of changes in membrane deflections. The detection limit for leak was 8E-13 mbar l/s. For comparison, strength and leak tests were also performed with regular fusion bonded wafers annealed at 1100 degreesC. The PAB was found to withstand post-processing steps such as RCA cleaning, 24 h in de...

  2. DIAGNOSIS AND MANAGEMENT OF ANTERIOR CSF LEAKS : OUR EXPERIENCE

    Directory of Open Access Journals (Sweden)

    Probal

    2015-05-01

    Full Text Available CSF leaks through the nose (CSF rhinorrhea may occur due to defects in the anterior, middle or posterior cranial fossa. Among them, anterior CSF leaks are most commonly encountered in clinical practice and may be traumatic or spontaneous in origin. A pro mpt diagnosis is essential as the main risk of a persistent leak is the chance of developing life threatening meningitis. Radiological imaging by non - contrast high - resolution CT scan is the initial investigation of choice and shows the site of leak in most cases. In case of recent onset leaks, a period of conservative management is indicated. If conservative management fails, then the traditional neurosurgical procedures like craniotomy and other open approaches were the most preferred line of management of such leaks till a few years back. But now endoscopic repair of these leaks has provided a better alternative because of reduced surgical morbidity, hospital stay and costs. We present our initial experience with seven cases of anterior CSF rhinorrhea whic h were encountered in a two year period in our institute. Two out of three cases with recent onset leaks healed spontaneously with medical management while five cases required endoscopic repair with two surgical failures.

  3. Treelike networks accelerating capillary flow

    Science.gov (United States)

    Shou, Dahua; Ye, Lin; Fan, Jintu

    2014-05-01

    Transport in treelike networks has received wide attention in natural systems, oil recovery, microelectronic cooling systems, and textiles. Existing studies are focused on transport behaviors under a constant potential difference (including pressure, temperature, and voltage) in a steady state [B. Yu and B. Li, Phys. Rev. E 73, 066302 (2006), 10.1103/PhysRevE.73.066302; J. Chen, B. Yu, P. Xu, and Y. Li, Phys. Rev. E 75, 056301 (2007), 10.1103/PhysRevE.75.056301]. However, dynamic (time-dependent) transport in such systems has rarely been concerned. In this work, we theoretically investigate the dynamics of capillary flow in treelike networks and design the distribution of radius and length of local branches for the fastest capillary flow. It is demonstrated that capillary flow in the optimized tree networks is faster than in traditional parallel tube nets under fixed constraints. As well, the flow time of the liquid is found to increase approximately linearly with penetration distance, which differs from Washburn's classic description that flow time increases as the square of penetration distance in a uniform tube.

  4. Applicability of the leak before break concept

    International Nuclear Information System (INIS)

    Within the framework of the IAEA Extrabudgetary Programme on the Safety of WWER-440 Model 230 NPPs, a list of safety issues requiring broad studies of general interest have been agreed upon by an Advisory Group which met in Vienna in September 1990. The information on the status of the issues, and on amount of work already completed and under way in various countries, needs to be compiled. Moreover, an evaluation of what further work is required to resolve each of the issues is also necessary. In view of this, the IAEA has started the preparation of a series of status reports on the various issues. This report on the generic safety issue ''Applicability of the Leak Before Break Concept'' presents a comprehensive survey of technical information available in the field and identifies those which require further investigation. 50 refs, 15 figs, 2 tabs

  5. Canine snoops trained for pipeline leaks

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2000-06-01

    The training of dogs to detect leaks in gas lines is discussed. The most-up-to-date field pack monitor or sensor can only read down to 50 parts per million; dogs have proven that they can pick up particles of scent better than one part per billion, similar in magnitude to locating one specific grain of sand in a truck load. Dogs have the capacity to search not only for a single substance, but they can be trained also to search for specific combinations of different smells. Once trained, they are completely reliable and extremely cost effective. German shepherds are favoured for their sociability, desire for work and lack of 'hunting dog' instincts, which allows them to remain focused even in the presence of wildlife. Training begins at the puppy stage; to reach 'operational level' may require up to two years per animal.

  6. Leaking tankers: how much oil was spilled?

    International Nuclear Information System (INIS)

    A model to estimate leak rates from tankers has been developed for use in emergency situations when more direct oil-loss estimation methods are not available. The model includes algorithms for gravity outflow and air and water ingestion. Three laboratory tests were conducted using fresh water and canola oil to evaluate the model output. Comparison with results from the laboratory experiments indicate good correlation of model results with measured data. However, it is not yet possible in the case of very large crude carriers to answer the question 'how much oil was spilled?' Sensitivity analysis and further laboratory testing were suggested to determine the effect of factors such as: pressure vacuum relief valves that prevent cavitation in the event of tank puncture; changing outside water levels due to wave and tidal action; tank and hole dimensions; and the amount and density of the product.10 refs., 4 figs

  7. Progression of Diabetic Capillary Occlusion: A Model.

    Directory of Open Access Journals (Sweden)

    Xiao Fu

    2016-06-01

    Full Text Available An explanatory computational model is developed of the contiguous areas of retinal capillary loss which play a large role in diabetic maculapathy and diabetic retinal neovascularization. Strictly random leukocyte mediated capillary occlusion cannot explain the occurrence of large contiguous areas of retinal ischemia. Therefore occlusion of an individual capillary must increase the probability of occlusion of surrounding capillaries. A retinal perifoveal vascular sector as well as a peripheral retinal capillary network and a deleted hexagonal capillary network are modelled using Compucell3D. The perifoveal modelling produces a pattern of spreading capillary loss with associated macular edema. In the peripheral network, spreading ischemia results from the progressive loss of the ladder capillaries which connect peripheral arterioles and venules. System blood flow was elevated in the macular model before a later reduction in flow in cases with progression of capillary occlusions. Simulations differing only in initial vascular network structures but with identical dynamics for oxygen, growth factors and vascular occlusions, replicate key clinical observations of ischemia and macular edema in the posterior pole and ischemia in the retinal periphery. The simulation results also seem consistent with quantitative data on macular blood flow and qualitative data on venous oxygenation. One computational model applied to distinct capillary networks in different retinal regions yielded results comparable to clinical observations in those regions.

  8. Automatic recovery from resource exhaustion exceptions by collecting leaked resources

    Institute of Scientific and Technical Information of China (English)

    Zi-ying DAI; Xiao-guang MAO; Li-qian CHEN; Yan LEI

    2014-01-01

    Despite the availability of garbage collectors, programmers must manually manage non-memory fi nite system resources such as fi le descriptors. Resource leaks can gradually consume all available resources and cause programs to raise resource exhaustion exceptions. However, programmers commonly provide no effective recovery approach for resource exhaustion exceptions, which often causes programs to halt without completing their tasks. In this paper, we propose to automatically recover programs from resource exhaustion exceptions caused by resource leaks. We transform programs to catch resource exhaustion exceptions, collect leaked resources, and then retry the failure code. A resource collector is designed to identify leaked resources and safely release them. We implement our approach for Java programs. Experimental results show that our approach can successfully handle resource exhaustion exceptions caused by reported resource leaks and allow programs to complete their tasks with an average execution time increase of 2.52%and negligible bytecode size increase.

  9. 105 K-West isolation barrier leak recovery plan

    International Nuclear Information System (INIS)

    Leak testing is being performed in 105 KW to verify the performance of the isolation barriers which have been recently installed. When an 11 inch differential head is established between the main basin and the discharge chute, a leak-rate of approximately 30 - 35 gpm is observed. The leak-rate would be achieved by a 1.65'' - 2'' diameter hole (or equivalent). Analyses suggest that the flow is turbulent/laminar transitional (dominantly turbulent), which would be indicative of a single point leak, typical of a pipe or large opening. However, local vortex rotation is observed in the entry to the West transfer chute while no observable motion was seen in the East transfer chute: this may be an indication of seal leakage in the East isolation barrier. The potential for leakage had been considered during the design and field work planning stages. Review of potential leak detection technologies had been made; at the planning stage it was determined that location specific leak detection could be established relatively quickly, applying existing K Basins technology (dye or ultrasonics). The decision was made not to pre-stage leak detection since the equipment development is highly dependent on the nature and location of the leak, and the characteristics of the leak rate provides data which guides leak characterization technology. The expense could be deferred and potentially avoided without risk to critical path activity. Consistent with the above, a systematic recovery plan has been developed utilizing phased activities to provide for management discipline combined with timely diagnosis and correction. Because this activity is not critical path at this time, activities will be coordinated with other plant activity to optimize overall plant work. Particular care will be exercised in assuring that information gained from this recovery can be utilized in the more critical work in 105 KE

  10. Capillary pumped loop body heat exchanger

    Science.gov (United States)

    Swanson, Theodore D. (Inventor); Wren, deceased, Paul (Inventor)

    1998-01-01

    A capillary pumped loop for transferring heat from one body part to another body part, the capillary pumped loop comprising a capillary evaporator for vaporizing a liquid refrigerant by absorbing heat from a warm body part, a condenser for turning a vaporized refrigerant into a liquid by transferring heat from the vaporized liquid to a cool body part, a first tube section connecting an output port of the capillary evaporator to an input of the condenser, and a second tube section connecting an output of the condenser to an input port of the capillary evaporator. A wick may be provided within the condenser. A pump may be provided between the second tube section and the input port of the capillary evaporator. Additionally, an esternal heat source or heat sink may be utilized.

  11. Microfluidic PMMA interfaces for rectangular glass capillaries

    International Nuclear Information System (INIS)

    We present the design and fabrication of a polymeric capillary fluidic interface fabricated by micro-milling. The design enables the use of glass capillaries with any kind of cross-section in complex microfluidic setups. We demonstrate two different designs of the interface; a double-inlet interface for hydrodynamic focusing and a capillary interface with integrated pneumatic valves. Both capillary interfaces are presented together with examples of practical applications. This communication shows the design optimization and presents details of the fabrication process. The capillary interface opens up for the use of complex microfluidic systems in single-use glass capillaries. They also enable simple fabrication of glass/polymer hybrid devices that can be beneficial in many research fields where a pure polymer chip negatively affects the device's performance, e.g. acoustofluidics. (technical note)

  12. ISS Ammonia Leak Detection Through X-Ray Fluorescence

    Science.gov (United States)

    Camp, Jordan; Barthelmy, Scott; Skinner, Gerry

    2013-01-01

    Ammonia leaks are a significant concern for the International Space Station (ISS). The ISS has external transport lines that direct liquid ammonia to radiator panels where the ammonia is cooled and then brought back to thermal control units. These transport lines and radiator panels are subject to stress from micrometeorites and temperature variations, and have developed small leaks. The ISS can accommodate these leaks at their present rate, but if the rate increased by a factor of ten, it could potentially deplete the ammonia supply and impact the proper functioning of the ISS thermal control system, causing a serious safety risk. A proposed ISS astrophysics instrument, the Lobster X-Ray Monitor, can be used to detect and localize ISS ammonia leaks. Based on the optical design of the eye of its namesake crustacean, the Lobster detector gives simultaneously large field of view and good position resolution. The leak detection principle is that the nitrogen in the leaking ammonia will be ionized by X-rays from the Sun, and then emit its own characteristic Xray signal. The Lobster instrument, nominally facing zenith for its astrophysics observations, can be periodically pointed towards the ISS radiator panels and some sections of the transport lines to detect and localize the characteristic X-rays from the ammonia leaks. Another possibility is to use the ISS robot arm to grab the Lobster instrument and scan it across the transport lines and radiator panels. In this case the leak detection can be made more sensitive by including a focused 100-microampere electron beam to stimulate X-ray emission from the leaking nitrogen. Laboratory studies have shown that either approach can be used to locate ammonia leaks at the level of 0.1 kg/day, a threshold rate of concern for the ISS. The Lobster instrument uses two main components: (1) a microchannel plate optic (also known as a Lobster optic) that focuses the X-rays and directs them to the focal plane, and (2) a CCD (charge

  13. Leak testing of cryogenic components — problems and solutions

    Science.gov (United States)

    Srivastava, S. P.; Pandarkar, S. P.; Unni, T. G.; Sinha, A. K.; Mahajan, K.; Suthar, R. L.

    2008-05-01

    A prototype of Cold Neutron Source (CNS) for Dhruva Reactor is being manufactured at Centre for Design and Manufacture (CDM), BARC, Mumbai for validating the mechanical and thermal engineering design aspects, besides checking the integrity of all joints and components at low temperature, 77K. Task of a Cold Neutron Source is to generate cold neutrons by cooling down the thermal neutrons, which are originally produced in a nuclear research reactor. The complete Cold Neutron Source system comprises a complex arrangement of moderator pot, transfer line (piping), pumps, refrigerators, storage tanks, a heat exchanger and associated controls and instrumentation. The heart of the system is moderator pot in which water (moderator) is cooled down by Liquid Nitrogen (LN2) being circulated through an annular cavity machined on the walls of the pot. Transfer lines for LN2 basically consist of two concentric Stainless Steel flexible pipes, which are joined to the inlet and outlet Aluminium tubes of the moderator pot through transition joints. Leak in any component may result in loss of liquid Nitrogen, degradation of vacuum, which in turn may affect the heat removal efficiency of the source. Hence, leak testing was considered a very important quality control tool and all joints and components were subjected to helium leak test using mass spectrometer leak detector (MSLD) at cryogenic temperature. During one of the earlier experiments, flow of LN2 through inner flexible pipe of the transfer line resulted in rise of pressure in the vacuum annulus and sweating on the outer flexible pipe. After investigations it was found that large thermal stress compounded with mechanical stress resulted in cracks in the inner pipe. Accordingly design was modified to get leak proof transfer line assembly. Further, during leak testing of thin wall moderator pot, gross leak was observed on the outer jacket welded joint. Leak was so large that even a small amount of Helium gas in the vicinity of the

  14. DNA Sequencing Using capillary Electrophoresis

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Barry Karger

    2011-05-09

    The overall goal of this program was to develop capillary electrophoresis as the tool to be used to sequence for the first time the Human Genome. Our program was part of the Human Genome Project. In this work, we were highly successful and the replaceable polymer we developed, linear polyacrylamide, was used by the DOE sequencing lab in California to sequence a significant portion of the human genome using the MegaBase multiple capillary array electrophoresis instrument. In this final report, we summarize our efforts and success. We began our work by separating by capillary electrophoresis double strand oligonucleotides using cross-linked polyacrylamide gels in fused silica capillaries. This work showed the potential of the methodology. However, preparation of such cross-linked gel capillaries was difficult with poor reproducibility, and even more important, the columns were not very stable. We improved stability by using non-cross linked linear polyacrylamide. Here, the entangled linear chains could move when osmotic pressure (e.g. sample injection) was imposed on the polymer matrix. This relaxation of the polymer dissipated the stress in the column. Our next advance was to use significantly lower concentrations of the linear polyacrylamide that the polymer could be automatically blown out after each run and replaced with fresh linear polymer solution. In this way, a new column was available for each analytical run. Finally, while testing many linear polymers, we selected linear polyacrylamide as the best matrix as it was the most hydrophilic polymer available. Under our DOE program, we demonstrated initially the success of the linear polyacrylamide to separate double strand DNA. We note that the method is used even today to assay purity of double stranded DNA fragments. Our focus, of course, was on the separation of single stranded DNA for sequencing purposes. In one paper, we demonstrated the success of our approach in sequencing up to 500 bases. Other

  15. A New Conductivity Detector for Capillary Electrophoresis

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A new conductivity detector for capillary electrophoresis consisting of an electrochemical cell and a conductive meter was developed. In the cell, the microelectrode and capillary were inserted through the cell wall and fixed by screws and sealing ring, the ends of microelectrode and capillary were located by a guide with two cross holes. LOD for K+ was 1.5×10-5 mol/L.

  16. Serum proteins analysis by capillary electrophoresis

    OpenAIRE

    Uji, Yoshinori; Okabe, Hiroaki

    2001-01-01

    The purpose of this study was to evaluate the efficacy of multi-capillary electrophoresis instrument in clinical laboratory. An automated clinical capillary electrophoresis system was evaluated for performing serum proteins electrophoresis and immuno-fixation electrophoresis by subtraction. In this study the performance of capillary electrophoresis was compared with the cellulose acetate membrane electrophoresis and agarose gel immunofixation electrophoresis for serum proteins. The results of...

  17. Cytokine Analysis by Immunoaffinity Capillary Electrophoresis

    OpenAIRE

    Mendonca, Mark; Kalish, Heather

    2013-01-01

    Immunoaffinity capillary electrophoresis (ICE) is a powerful tool used to detect and quantify target proteins of interest in complex biological fluids. The target analyte is captured and bound to antibodies immobilized onto the wall of a capillary, labeled in situ with a fluorescent dye, eluted and detected online using laser-induced fluorescence following electrophoretic separation. Here, we illustrate how to construct an immunoaffinity capillary and utilize it to run ICE in order to capture...

  18. Slope wavenumber spectrum models of capillary and capillary-gravity waves

    Institute of Scientific and Technical Information of China (English)

    贾永君; 张杰; 王岩峰

    2010-01-01

    Capillary and capillary-gravity waves possess a random character, and the slope wavenumber spectra of them can be used to represent mean distributions of wave energy with respect to spatial scale of variability. But simple and practical models of the slope wavenumber spectra have not been put forward so far. In this article, we address the accurate definition of the slope wavenumber spectra of water surface capillary and capillary-gravity waves. By combining the existing slope wavenumber models and using th...

  19. Beals Syndrome

    Science.gov (United States)

    ... Boards & Staff Annual Report & Financials Contact Us Donate Marfan & Related Disorders What is Marfan Syndrome? What are ... the syndrome. How does Beals syndrome compare with Marfan syndrome? People with Beals syndrome have many of ...

  20. Autogenous Metallic Pipe Leak Repair in Potable Water Systems.

    Science.gov (United States)

    Tang, Min; Triantafyllidou, Simoni; Edwards, Marc A

    2015-07-21

    Copper and iron pipes have a remarkable capability for autogenous repair (self-repair) of leaks in potable water systems. Field studies revealed exemplars that metallic pipe leaks caused by nails, rocks, and erosion corrosion autogenously repaired, as confirmed in the laboratory experiments. This work demonstrated that 100% (N = 26) of 150 μm leaks contacting representative bulk potable water in copper pipes sealed autogenously via formation of corrosion precipitates at 20-40 psi, pH 3.0-11.0, and with upward and downward leak orientations. Similar leaks in carbon steel pipes at 20 psi self-repaired at pH 5.5 and 8.5, but two leaks did not self-repair permanently at pH 11.0 suggesting that water chemistry may control the durability of materials that seal the leaks and therefore the permanence of repair. Larger 400 μm holes in copper pipes had much lower (0-33%) success of self-repair at pH 3.0-11.0, whereas all 400 μm holes in carbon steel pipes at 20 psi self-repaired at pH 4.0-11.0. Pressure tests indicated that some of the repairs created at 20-40 psi ambient pressure could withstand more than 100 psi without failure. Autogenous repair has implications for understanding patterns of pipe failures, extending the lifetime of decaying infrastructure, and developing new plumbing materials. PMID:26057741

  1. Incidence and risk factors predisposing anastomotic leak after transhiatal esophagectomy

    International Nuclear Information System (INIS)

    The objective of our study was to identify the incidence and risk factors of anastomotic leaks following transhiatal esophagectomy (THE). A prospective study was conducted on 61 patients treated for carcinoma of the esophagus between 2006 and 2007. We examined the following variables: age, gender, preoperative cardiovascular function, intraoperative complications such as hypotension, arrhythmia, mediastinal manipulation period, blood loss volume, blood transfusion, duration of surgery, postoperative complications such as anastomotic leak, anastomotic stricture, requiring reoperation, respiratory complications, and total morbidity and mortality. Variables were compared between the patients with and without anastomotic leak. T-test for quantitative variables and Chi-square test for qualitative variables were used to find out any relationship. P value less than 0.05 was considered significant. Out of 61 patients, anastomotic leaks occurred in 13 (21.3%). Weight loss, forced expiratory volume (FEV1) < 2 lit, preoperative albumin, intaoperative blood loss volume, and respiratory complication were associated with the anastomotic leak in patients undergoing THE. Anastomotic leaks were the leading cause of postoperative morbidity, anastomotic stricture, and reoperation. Anastomotic leakage is a life-threatening postoperative complication. Careful attention to the factors contributing to the development of a leak can reduce the incidence of anastomotic complications postoperatively. (author)

  2. Detection of ground water leak points and water sampling technique

    Energy Technology Data Exchange (ETDEWEB)

    Harada, Kazuyuki (Tokyo Gas Co., Ltd., Tokyo, (Japan))

    1989-09-10

    In order to realize effective survey for ground water leak points in city gas pipelines and to reduce the repairing period and its cost, development on the survey method and devices were carried out. Then the process to detect ground water leak points and water sampling technique were developed for mainly easily available device and jig. The object of the process is low pressure main and branch pipelines of 50-300mm in diameter, and the process detect ground water leak points without excavation, finds drainage and water sampling is done. It investigates the range of ground water leak points by gas moisture gaze, and specifies ground water leak points by television camera of fiberscope. Water in the pipeline is absorbed by electric motor driven water vacuum pump, applying the hoses provided with water sensor to detect water leak points. The device to be inserted into in-service pipelines was developed so as to safely and surely insert device into in-service pipeline by way of conventional drilling device and coupler. The effective survey for ground leak water is able to realized which was depended upon sixth sense and experience. 1 ref., 5 figs., 1 tab.

  3. Fuzzy clustering of infrared images applied in air leak localization

    Science.gov (United States)

    Ge, Nan; Peng, Guang-zheng; Jiang, Mu-zhou

    2009-07-01

    Most current research into the localization of leaks is focused on leaks of petroleum and natural gas pipelines, while there is very little new work being done on the leakage of vessels. A novel air-leak diagnosis and localization method based on infrared thermography is described in this paper, which is developed in an attempt to overcome the disadvantages of low efficiency and poor anti-jamming ability associated with the traditional approaches to localization of leaks from a vessel. The method achieves leak positioning through a factor θ based kernelized fuzzy clustering segmentation done to weighted differential thermal images of the test objects. The temperature difference factor θ is inventively built as a parameter changed with temperature range of the target region, in order to enhance the robustness and the interference proof ability of the algorithm. Heat transfer simulation with air-leak flow is addressed by the finite element analysis. The experimental results indicate that the method proposed is effective and sensitive. The purpose of air-leak localization has been reached.

  4. Electromigration dispersion in Capillary Electrophoresis

    CERN Document Server

    Chen, Zhen; 10.1007/s11538-011-9708-7

    2012-01-01

    In a previous paper (S. Ghosal and Z. Chen Bull. Math. Biol. 2010, vol. 72, pg. 2047) it was shown that the evolution of the solute concentration in capillary electrophoresis is described by a nonlinear wave equation that reduced to Burger's equation if the nonlinearity was weak. It was assumed that only strong electrolytes (fully dissociated) were present. In the present paper it is shown that the same governing equation also describes the situation where the electrolytic buffer consists of a single weak acid (or base). A simple approximate formula is derived for the dimensionless peak variance which is shown to agree well with published experimental data.

  5. Microbeam-coupled capillary electrophoresis

    International Nuclear Information System (INIS)

    Within the first few microseconds following a charged particle traversal of a cell, numerous oxygen and nitrogen radicals are formed along the track. Presented here is a method, using capillary electrophoresis, for simultaneous measurement, within an individual cell, of specific reactive oxygen species, such as the superoxide radical (O2-*) as well as the native and oxidised forms of glutathione, an ubiquitous anti-oxidant that assists the cell in coping with these species. Preliminary data are presented as well as plans for integrating this system into the charged particle microbeam at Columbia University. (authors)

  6. Capillary electrophoresis theory and practice

    CERN Document Server

    Grossman, Paul D

    1992-01-01

    This book is designed to be a practical guide, used by wide audience, including those new to CE, those more experienced, routine users, those interested in technology development, and those involved with applications research. References have been emphasized to allow the reader to explore the detailed specifics and theoretical foundations.This book draws together the rapidly evolving, diverse, and multidisciplinary subject of capillary electrophoresis (CE). It is designed as a practical guide to be used by a wide audience, including those new to CE as well as more experienced users. T

  7. Exotic containers for capillary surfaces

    Science.gov (United States)

    Concus, Paul; Finn, Robert

    1991-01-01

    This paper discusses 'exotic' rotationally symmetric containers that admit an entire continuum of distinct equilibrium capillary free surfaces. The paper extends earlier work to a larger class of parameters and clarifies and simplifies the governing differential equations, while expressing them in a parametric form appropriate for numerical integration. A unified presentation suitable for both zero and nonzero gravity is given. Solutions for the container shapes are depicted graphically along with members of the free-surface continuum, and comments are given concerning possible physical experiments.

  8. Prediction of Gas Leak Tightness of Superplastically Formed Products

    OpenAIRE

    Snippe, Corijn H.C.; Meinders, T.

    2007-01-01

    In some applications, in this case an aluminium box in a subatomic particle detector containing highly sensitive detecting devices, it is important that a formed sheet should show no gas leak from one side to the other. In order to prevent a trial-and-error procedure to make this leak tight box, a method is set up to predict if a formed sheet conforms to the maximum leak constraint. The technique of superplastic forming (SPF) is used in order to attain very high plastic strains before failure...

  9. 105-KE Basin isolation barrier leak rate test analytical development

    International Nuclear Information System (INIS)

    This report provides analytical developments in support of the proposed leak rate test of the 105-KE Basin. The analytical basis upon which the K-basin leak test results will be used ti determine the basin leakage rates is developed in this report. The leakage of the K-Basin isolation barriers under accident conditions will be determined from the test results. There are two fundamental flow regimes that may exist in the postulated K-Basin leakage, viscous laminar and turbulent flow. An analytical development is presented for each flow regime. The basic geometry and nomenclature of the postulated leak paths are denoted

  10. Expeditious remediation of a leaking underground tank

    International Nuclear Information System (INIS)

    An inactive leaking diesel fuel tank, at a TV transmitter site in Memphis, Tennessee, was removed just prior to transfer of ownership. The removal of contaminated soil resulted in an excavated to a depth of about 5.5 m (18 ft) by a contractor from Memphis. This excavation partially undermined the building, and furthermore exposed two friction pilings which supported the transmitter building. Rogers and Associates Engineering (RAE) accepted project management. The excavation was backfilled with gravel to stabilize the site and prevent damage to the foundation of the building. Site characterization, including bore holes and groundwater monitoring wells indicated that essentially all of the remaining contamination was in the area immediately beneath where the tank had been located. Final mitigation was performed using a 1.5-m (5-ft) diameter caisson auger to excavate the material to a depth of 11 m beneath the surface. A steel casing was driven behind the auger to the full depth to provide site stability and prevent caving. Simultaneous drilling and driving the casing resulted in essentially no mixing of material and removal of the contaminated soil, without impact on the building. Sampling from the excavation and additional groundwater monitoring verified full remediation had been accomplished. The monitoring wells were plugged according to Tennessee requirements and the area of the excavation was capped. This phase of the site characterization and remediation were completed within about one month and the State verified the closure

  11. Compact Instruments Measure Helium-Leak Rates

    Science.gov (United States)

    Stout, Stephen; Immer, Christopher

    2003-01-01

    Compact, lightweight instruments have been developed for measuring small flows of helium and/or detecting helium leaks in solenoid valves when the valves are nominally closed. These instruments do not impede the flows when the valves are nominally open. They can be integrated into newly fabricated valves or retrofitted to previously fabricated valves. Each instrument includes an upstream and a downstream thermistor separated by a heater, plus associated analog and digital heater-control, signal- conditioning, and data-processing circuits. The thermistors and heater are off-the-shelf surface mount components mounted on a circuit board in the flow path. The operation of the instrument is based on a well-established thermal mass-flow-measurement technique: Convection by the flow that one seeks to measure gives rise to transfer of heat from the heater to the downstream thermistor. The temperature difference measured by the thermistors is directly related to the rate of flow. The calibration curve from temperature gradient to helium flow is closely approximated via fifth-order polynomial. A microprocessor that is part of the electronic circuitry implements the calibration curve to compute the flow rate from the thermistor readings.

  12. Sheathless interface for coupling capillary electrophoresis with mass spectrometry

    Science.gov (United States)

    Wang, Chenchen; Tang, Keqi; Smith, Richard D.

    2014-06-17

    A sheathless interface for coupling capillary electrophoresis (CE) with mass spectrometry is disclosed. The sheathless interface includes a separation capillary for performing CE separation and an emitter capillary for electrospray ionization. A portion of the emitter capillary is porous or, alternatively, is coated to form an electrically conductive surface. A section of the emitter capillary is disposed within the separation capillary, forming a joint. A metal tube, containing a conductive liquid, encloses the joint.

  13. Diagnostics of a high current capillary discharge

    International Nuclear Information System (INIS)

    We have demonstrated that thin (10 to 25 μm diameter) capillaries can be fabricated in suitably configured insulators for use in pulse power machines. Large currents can be used to heat these capillaries which produce photons with an energies greater than 1 keV

  14. Pulmonary capillary haemangiomatosis in a premature infant

    International Nuclear Information System (INIS)

    Pulmonary capillary haemangiomatosis (PCH) is a rare disorder characterized by widespread capillary proliferation in the lung, infiltrating the interstitium and the alveolar walls. We present the HRCT features of PCH in a surviving ex-premature infant. To our knowledge, this is a unique case of the radiological features of PCH in a young living infant. (orig.)

  15. Pulmonary capillary haemangiomatosis in a premature infant

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Cicero J.T.A.; Massie, John; Mandelstam, Simone A. [University of Melbourne, Royal Children' s Hospital, Parkville, VIC (Australia)

    2005-06-01

    Pulmonary capillary haemangiomatosis (PCH) is a rare disorder characterized by widespread capillary proliferation in the lung, infiltrating the interstitium and the alveolar walls. We present the HRCT features of PCH in a surviving ex-premature infant. To our knowledge, this is a unique case of the radiological features of PCH in a young living infant. (orig.)

  16. Distributed Leak Detection System Using Structure-Borne Noise Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Manned spacecraft are vulnerable to air leaks caused by micrometeorite and space debris impact. The ability to detect and quickly locate and mitigate a pressure...

  17. Leak in spiral weld in a 16 inches gas pipeline

    Energy Technology Data Exchange (ETDEWEB)

    Fazzini, Pablo G.; Bona, Jeremias de [GIE S.A., Mar del Plata (Argentina); Otegui, Jose L. [University of Mar del Plata (Argentina)

    2009-07-01

    This paper discusses a failure analysis after a leak in the spiral weld of a 16 inches natural gas pipeline, in service since 1974. The leak was the result of the coalescence of two different defects, on each surface of the pipe wall, located in the center of the inner cord of the helical DSAW weld. Fractographic and metallographic studies revealed that the leak was a combination of three conditions. During fabrication of the pipe, segregation in grain boundary grouped in mid weld. During service, these segregations underwent a process of selective galvanic corrosion. One of these volumetric defects coincided with a tubular pore in the outer weld. Pigging of the pipeline in 2005 for cleaning likely contributed to the increase of the leak flow, when eliminating corrosion product plugs. Although these defects are likely to repeat, fracture mechanics shows that a defect of this type is unlikely to cause a blowout. (author)

  18. Backstreaming of Impurity Gas Through a Leak in Pressurized Vessel

    CERN Document Server

    Dauvergne, J P

    1998-01-01

    The presence of a leak in a vessel containing pure gas can induce the contamination by atmospheric gas diffusing into the vessel. In order to avoid this, a gas which has to be kept pure also in presen ce of a leak is usually pressurized, to reduce the flow of contaminating gas through the leak owing to the molecular drag by the outstreaming pure gas. In this paper, a simple model calculation of ba ckstreaming based on the solution of the diffusion + drag equation in cylindrical coordinates is presented. It is shown that both the pressure difference and the dimension of the leak are critical in determining the contaminating flow, a maximum in the backstreaming flow appearing when the drag velocity of the outstreaming gas equals the diffusion velocity.

  19. Leaking Underground Tanks in Rhode Island; LUSTs12

    Data.gov (United States)

    University of Rhode Island Geospatial Extension Program — This dataset shows the location of storage tanks and associated piping used for petroleum and certain hazardous substances that have experienced leaks as determined...

  20. In-Space Distributed Fiber Optic Hydrogen Leak Sensor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Broadband Photonics Inc. proposes development of a patent-pending distributed fiber optic sensor for in-space hydrogen leak detection. Reliable and fast detection...

  1. Distributed Leak Detection System Using Structure-Borne Noise Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Manned spacecraft are vulnerable to air leaks caused by micrometeoroid and space debris impact. The ability to detect and quickly locate and mitigate a pressure...

  2. Detection of gas leaks in the subsurface environment

    Science.gov (United States)

    Ghandehari, Masoud; Khalil, Gamal; Kimura, Fletcher

    2005-05-01

    Leaking valves, connections and distribution pipelines are significant sources of fugitive gas and volatile chemical emissions in chemical manufacturing, gas production, transmission, and oil refineries. A gas leak detection method has been developed based on continuous monitoring of the oxygen concentration surrounding a natural gas pipeline. The method utilizes optical fibers coated with an oxygen permeable polymeric film containing a luminescent sensor molecule. When the specialty fiber is illuminated by a light source that excites the luminophor, the functional cladding compound has the ability to detect and quantify leaks by measuring small changes in oxygen concentrations in the surrounding environment. Key features of the technology include long-term performance based on well understood platinum porphyrin chemistry, in addition to the capability of distributed sensing using fiber optic evanescent field spectroscopy. Results of leak detection in various environments namely atmospheric conditions, dry sand as well as saturated sand is reported, along with test results on long term system performance.

  3. STURGE - WEBER SYNDROME: REVIEW OF LITERATURE

    OpenAIRE

    Mamatha; Mariappan; Khushbu; Shekar

    2015-01-01

    The Sturge - Weber syndrome is a sporadic congenital neurocutaneous disorder with port - wine stain affecting the facial skin in the distribution of the ophthalmic branch of the trigeminal nerve, abnormal capillary venous vessels in the leptomeninges of the brain and choroid resulting in glaucoma, seizures, st roke and intellectual disability . [1] Sturge - Weber syndrome and port - wine stains are believed to be caused by Somatic Mutation in...

  4. EBR-II water-to-sodium leak detection system

    International Nuclear Information System (INIS)

    The water-to-sodium leak detection system installed at EBR-II in April, 1975, is described in detail. Topics covered include operational characteristics, maintenance problems, alarm functions, background hydrogen level data, and future plans for refinements to the system. Particular emphasis is given to the failures of eight of the ten leak detectors due to sodium-to-vacuum leakage, and the program anticipated for complete recovery of the system

  5. Reducing gastrointestinal anastomotic leak rates: review of challenges and solutions

    OpenAIRE

    Phillips BR

    2016-01-01

    Benjamin R Phillips Department of Surgery, Division of Colon and Rectal Surgery, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA Abstract: Various techniques and interventions have been developed in an effort to obviate gastrointestinal anastomotic leaks. This review is intended to delineate potential modifications that can be made to reduce the risk of anastomotic leaks following gastrointestinal surgery. It may also serve to aid in identifying pat...

  6. SmartBall™: Free Swimming Leak Detection System

    OpenAIRE

    ECT Team, Purdue

    2008-01-01

    Leak detection systems measure ultrasonic noise, infrared temperature variances or electrical flux to detect leakage in structures like, pipes, tanks, geo-membrane retaining structures etc. SmartBall® is a free flowing leak detection system developed by Pure Technologies. It consists of a foam ball that has a smaller aluminum ball at its core. This aluminum core houses an ultrasonic device that sends ultrasonic signals and also collects the reflected sound waves.

  7. Identification of sewage leaks by active remote-sensing methods

    Science.gov (United States)

    Goldshleger, Naftaly; Basson, Uri

    2016-04-01

    The increasing length of sewage pipelines, and concomitant risk of leaks due to urban and industrial growth and development is exposing the surrounding land to contamination risk and environmental harm. It is therefore important to locate such leaks in a timely manner, to minimize the damage. Advances in active remote sensing Ground Penetrating Radar (GPR) and Frequency Domain Electromagnetic (FDEM) technologies was used to identify leaking potentially responsible for pollution and to identify minor spills before they cause widespread damage. This study focused on the development of these electromagnetic methods to replace conventional acoustic methods for the identification of leaks along sewage pipes. Electromagnetic methods provide an additional advantage in that they allow mapping of the fluid-transport system in the subsurface. Leak-detection systems using GPR and FDEM are not limited to large amounts of water, but enable detecting leaks of tens of liters per hour, because they can locate increases in environmental moisture content of only a few percentage along the pipes. The importance and uniqueness of this research lies in the development of practical tools to provide a snapshot and monitoring of the spatial changes in soil moisture content up to depths of about 3-4 m, in open and paved areas, at relatively low cost, in real time or close to real time. Spatial measurements performed using GPR and FDEM systems allow monitoring many tens of thousands of measurement points per hectare, thus providing a picture of the spatial situation along pipelines and the surrounding. The main purpose of this study was to develop a method for detecting sewage leaks using the above-proposed geophysical methods, since their contaminants can severely affect public health. We focused on identifying, locating and characterizing such leaks in sewage pipes in residential and industrial areas.

  8. Robust sensor placement for leak location: analysis and design

    OpenAIRE

    Blesa, Joaquim; Nejjari, Fatiha; Sarrate, Ramon

    2016-01-01

    In this paper, a nominal sensor placement methodology for leak location in water distribution networks is presented. To reduce the size and the complexity of the optimization problem a clustering technique is combined with the nominal sensor placement methodology. Some of the pressure sensor placement methods for leak detection and location in water distribution networks are based on the pressure sensitivity matrix analysis. This matrix depends on the network demands, which are nondeterminist...

  9. Space Shuttle RCS Oxidizer Leak Repair for STS-26

    Science.gov (United States)

    Delventhal, R. A.; Faget, N. M.

    1989-01-01

    Following propellant loading of the Space Shuttle's reaction control system (RCS) for mission STS 26, an oxidizer leak was detected in the left orbital maneuvering system (OMS) pod, where the RCS is located. Subsequent investigation determined that the leak was isolated at a mechanical Dynatube fitting near the RCS nitrogen tetroxide tank. An intense effort was initiated to design, fabricate, and qualify a sealing device to stop the oxidizer leak externally so that the Space Shuttle launch could proceed. It was discovered that sealing devices called clamshells were widely used throughout the petrochemical and power generation industries to stop leaks developed in large diameter pipes which carry steam or other hazardous fluids. These clamshells are available in different diameters and strengths and are placed around the pipe at the location of the leak. A sealing compound is then injected under high pressure into the clamshell to stop the leak. This technology was scaled down and applied to the problem of stopping the leak on the Orbiter, which was on a half-inch diameter line in a nearly inaccessible location. Many obstacles had to be overcome such as determining that the sealing material would be compatible with the nitrogen tetroxide and ensuring that the clamshell would actually fit around the Dynatube fitting without interfering with other lines which were in close proximity. The effort at the NASA Johnson Space Center included materials compatibility testing of several sealants, design of a clamshell to fit in the confined compartment, and manufacture and qualification of the flight hardware. A clamshell was successfully placed around the Dynatube fitting on the Orbiter and the oxidizer leak was terminated. Then it was decided to apply this technology further and design clamshells for other mechanical fittings onboard the Orbiter and develop sealing compounds which will be compatible with fuels such as monomethyl hydrazine (MMH). The potential exists for

  10. Rio Vista gas leak study: Belleaire Gas Field, California

    International Nuclear Information System (INIS)

    The Rio Vista gas leak study evaluated methods for remotely sensing gas leaks from buried pipelines and developed methods to elucidate methane transport and microbial oxidation in soils. Remote-sensing methods were evaluated by singing gas leaks along an abandoned Pacific Gas and Electric (PG ampersand E) gas field collection line in northern California and applying surface-based and airborne remote-sensing techniques in the field, including thermal imaging, laser imaging, and multispectral imagery. The remote-sensing techniques exhibited limitations in range and in their ability to correlate with ground truth data. To elucidate methane transport and microbial oxidation in soils, a study of a controlled leak permitted field testing of methods so that such processes could be monitored and evaluated. Monitoring and evaluation techniques included (1) field measurement of soil-gas concentrations, temperatures, and pressures; (2) laboratory measurement of soil physical/chemical properties and activity of methane-oxidizing microorganisms by means of field samples; and (3) development of a preliminary numerical analysis technique for combined soil-gas transport/methane oxidation. Soil-gas concentrations at various depths responded rapidly to the high rate of gas leakage. The number of methane-oxidizing microorganisms in site soils rapidly increased when the gas leak was initiated and decreased after the leak was terminated. The preliminary field, laboratory, and numerical analysis techniques tested for this study of a controlled gas leak could be successfully applied to future studies of gas leaks. Because soil-gas movement is rapid and temporally variable, the use of several complementary techniques that permit generalization of site-specific results is favored

  11. Spectroscopic Approach to Capillary-Alveolar Membrane Damage Induced Acute Lung Injury

    Directory of Open Access Journals (Sweden)

    Jing Wang

    1999-01-01

    Full Text Available BACKGROUND: Acute (or adult respiratory distress syndrome (ARDS is often associated with a high mortality rate in the critical care population. The term acute lung injury (ALI, a primitive phase of ARDS, was introduced by the European and American consensus groups to provide early diagnoses of ARDS. The pathophysiological characterization of ALI/ARDS – an increased pulmonary capillary-alveolar membrane barrier permeability – is generally not included in current intensive care unit diagnosis criteria.

  12. FUZZY INFERENCE BASED LEAK ESTIMATION IN WATER PIPELINES SYSTEM

    Directory of Open Access Journals (Sweden)

    N. Lavanya

    2015-01-01

    Full Text Available Pipeline networks are the most widely used mode for transporting fluids and gases around the world. Leakage in this pipeline causes harmful effects when the flowing fluid/gas is hazardous. Hence the detection of leak becomes essential to avoid/minimize such undesirable effects. This paper presents the leak detection by spectral analysis methods in a laboratory pipeline system. Transient in the pressure signal in the pipeline is created by opening and closing the exit valve. These pressure variations are captured and power spectrum is obtained by using Fast Fourier Transform (FFT method and Filter Diagonalization Method (FDM. The leaks at various positions are simulated and located using these methods and the results are compared. In order to determine the quantity of leak a 2 × 1 fuzzy inference system is created using the upstream and downstream pressure as input and the leak size as the output. Thus a complete leak detection, localization and quantification are done by using only the pressure variations in the pipeline.

  13. Influence of Crack Morphology on Leak Before Break Margins

    International Nuclear Information System (INIS)

    The purpose of the project is to evaluate the deterministic LBB-margins for different pipe systems in a Swedish PWR-plant and using different crack morphology parameters. Results: - The influence of crack morphology on Leak Before Break (LBB) margins is studied. The subject of the report is a number of LBB-submittals to SKI where deterministic LBB-margins are reported. These submittals typically uses a surface roughness of 0.0762 mm (300 microinch) and number of turns equal to zero and an in-house code for the leak rate evaluations. The present report has shown that these conditions give the largest LBB-margins both in terms of the quotient between the critical crack length and the leakage crack size and for the leak rate margin. - Crack morphology parameters have a strong influence on the leak rate evaluations. Using the SQUIRT code and more recent recommendations for crack morphology parameters, it is shown that in many cases the evaluated margins, using 1 gpm as the reference leak rate detection limit, are below the safety factor of 2 on crack size and 10 on leak rate, which is generally required for LBB approval. - The effect of including weld residual stresses on the LBB margins is also investigated. It is shown that for the two examples studied, weld residual stresses were important for the small diameter thin wall pipe whereas it was negligible for the large diameter thick wall pipe which had a self-balanced weld residual stress distribution

  14. Trouble shooting fuel leak at Shika Nuclear Power Station Unit No.2

    International Nuclear Information System (INIS)

    Power Suppression Testing (PST) is recommend for BWR in fuel leak occur. Operation by PST allows to identify leaked fuel bundle, suppresses its power and continue plant operation safely. Shika Nuclear Power Station Unit No.2 (Shika-2) has an experience fuel leak in its 2nd operation cycle, April 2009. This paper describes experience of trouble shooting fuel leak at Shika-2. (author)

  15. Beyond WikiLeaks implications for the future of communications, journalism and society

    CERN Document Server

    Brevini, Benedetta; McCurdy, Patrick

    2013-01-01

    The 2010 release of US embassy diplomatic cables put WikiLeaks into the international spotlight. Revelations by the leaks sparked intense debate within international diplomacy, journalism and society. This book reflects on the implications of WikiLeaks across politics and media, and on the results of leak journalism and transparency activism.

  16. Fugitive methane emissions from leak-prone natural gas distribution infrastructure in urban environments.

    Science.gov (United States)

    Hendrick, Margaret F; Ackley, Robert; Sanaie-Movahed, Bahare; Tang, Xiaojing; Phillips, Nathan G

    2016-06-01

    Fugitive emissions from natural gas systems are the largest anthropogenic source of the greenhouse gas methane (CH4) in the U.S. and contribute to the risk of explosions in urban environments. Here, we report on a survey of CH4 emissions from 100 natural gas leaks in cast iron distribution mains in Metro Boston, MA. Direct measures of CH4 flux from individual leaks ranged from 4.0 - 2.3 × 10(4) g CH4•day(-1). The distribution of leak size is positively skewed, with 7% of leaks contributing 50% of total CH4 emissions measured. We identify parallels in the skewed distribution of leak size found in downstream systems with midstream and upstream stages of the gas process chain. Fixing 'superemitter' leaks will disproportionately stem greenhouse gas emissions. Fifteen percent of leaks surveyed qualified as potentially explosive (Grade 1), and we found no difference in CH4 flux between Grade 1 leaks and all remaining leaks surveyed (p = 0.24). All leaks must be addressed, as even small leaks cannot be disregarded as 'safely leaking.' Key methodological impediments to quantifying and addressing the impacts of leaking natural gas distribution infrastructure involve inconsistencies in the manner in which gas leaks are defined, detected, and classified. To address this need, we propose a two-part leak classification system that reflects both the safety and climatic impacts of natural gas leaks. PMID:27023280

  17. Leigh syndrome

    International Nuclear Information System (INIS)

    A male infant developed hypotonia at 5 months, vomiting, diarrhea, fever, generalized clonic convulsion, tonic spasm and periodical opisthotonus at 8 months, swallowing difficulty at 10 months, pes equinovarus and optic atrophy at 11 months, and then tachypnea, and died at 14 months of age. Parents were consanguinous. Laboratory studies revealed elevated serum LDH, CPK, lactate and Pyruvate. TPP-ATP phosphoryl transferase inhibitor was negative in urine. EEG showed irregular and diffuse slow waves and periodic diffuse spike and waves. CT scan at 9 months of age showed slightly low attenuation areas in the putamen bilaterally. At 11 months, a diffuse cerebral atrophy was found, and the low attenuation of the basal ganglia became more definite. No enhanced lesion was seen at 13 months of age. Thiamine tetra-hydrofurfuryl disulfide and lipoic acid were tried without success. The pathological findings of the brain were astrogliosis and proliferation of capillaries in putamen, thalamus, caudate neucleus, substantia nigra, pontine brachium and cerebral cortex, which were symmetrically involved. The symmetrical cavitation was found in putamen. Optic nerve and mamillary body were spared. CT scan findings corresponded well with the pathology of the necrotic lesions of the brain. It was concluded that these CT scan pictures described above may be diagnostic of Leigh syndrome. (author)

  18. Capillary Discharge XUV Radiation Source

    Directory of Open Access Journals (Sweden)

    M. Nevrkla

    2009-01-01

    Full Text Available A device producing Z-pinching plasma as a source of XUV radiation is described. Here a ceramic capacitor bank pulse-charged up to 100 kV is discharged through a pre-ionized gas-filled ceramic tube 3.2 mm in diameter and 21 cm in length. The discharge current has amplitude of 20 kA and a rise-time of 65 ns. The apparatus will serve as experimental device for studying of capillary discharge plasma, for testing X-ray optics elements and for investigating the interaction of water-window radiation with biological samples. After optimization it will be able to produce 46.9 nm laser radiation with collision pumped Ne-like argon ions active medium. 

  19. Geometry of the capillary net in human hearts.

    Science.gov (United States)

    Rakusan, K; Cicutti, N; Spatenka, J; Samánek, M

    1997-01-01

    The geometry of the coronary capillary bed in human hearts was studied using samples obtained during cardiac surgery of children operated for tetralogy of Fallot and samples from fresh normal hearts used for valve harvesting. The results revealed a similar coronary capillary density and heterogeneity of capillary spacing in samples from both groups. A double-staining method was used to distinguish between capillary segments close to the feeding arteriole (proximal capillaries) and segments distant from the arteriole (distal capillaries). In both groups of hearts, capillary segment length was consistently shorter on the venular than the arteriolar portion of the capillary. Similarly, capillary domain areas were also smaller and the resulting capillary supply unit was smaller along venular portions compared to arteriolar regions of the capillary bed. This distinctive geometry would provide advantageous geometric conditions for tissue oxygen supply. PMID:9176723

  20. Role of reactive oxygen species in pathogenesis of nephrotic syndrome

    OpenAIRE

    Ghodake, Santoshi R.; Suryakar, A. N.; Ankush, R. D.; Shaikh, K.; Katta, A. V.

    2010-01-01

    Nephrotic syndrome is the common chronic disorder characterized by alteration of permeability of the glomerular capillary wall, resulting in its inability to restrict the urinary loss of proteins. Nephrotic syndrome is characterized by heavy proteinuria, hypoalbuminemia, hyperlipidemia associated with peripheral edema. The molecular basis of glomerular permselectivity remains largely unknown. In recent years it has been proposed that Nephrotic syndrome is a consequence of an imbalance between...

  1. [Nephrotic syndrome associated with ampulloma].

    Science.gov (United States)

    López-Navidad, A; Colomina, J; Domingo, P; Franco, M; Algaba, F

    1989-06-01

    A patient is reported who presented simultaneously classic nephrotic syndrome and adenocarcinoma of the Vater ampulla. Morphological study of the renal biopsy revealed changes characteristic of membranous glomerulonephritis and subepithelial deposits. These deposits stained specifically for IgG and C'3 with a granular pattern, but deposits of CEA-antiCEA immune complexes were not found in glomerular capillaries. The association of nephrotic syndrome with lymphoproliferative diseases and a large variety of solid tumors, like carcinoma of the breast, bronchogenic, colon and stomach has been communicated, but the present case constitutes the first known association with adenocarcinoma of the Vater ampulla. PMID:2772382

  2. Pipe fracture evaluations for leak-rate detection: Deterministic models

    International Nuclear Information System (INIS)

    Regulatory Guide 1.45, Reactor Coolant Pressure Boundary Leakage Detection Systems was published by Nuclear Regulatory Commission (NRC) in May 1973, and its update is being considered. Updating this procedure can involve accounting for the current leak-detection instrumentation capabilities, experience from the accuracy of leak-detection systems in the past, and current analysis methods to assess the significance of the detectable leakage relative to the structural integrity of the plant. In this study, a three-phase effort was undertaken to conduct circumferentially cracked pipe fracture evaluations for applications to leak-rate detection requirement. Results from these probabilistic analyses can be used as a technical basis for future changes to leak-rate detection criterion. In this paper, a state-of-the-art review was conducted to evaluate the adequacy of current deterministic models for thermal-hydraulic analysis for estimation of leak rates, crack-opening area analysis for determination of crack geometry, and elastic-plastic fracture mechanics for prediction of maximum load-carrying capacity of circumferentially cracked piping systems (Phase 1). The results predicted from the above deterministic models were compared with experimental data obtained from the past NRC research programs. Based on the comparisons, it was concluded that the models considered in this study provide reasonably accurate estimates of leak rates, area of crack opening, and maximum load-carrying capacity of circumferentially cracked pipes. These validated deterministic models will be used for subsequent development of novel probabilistic models to evaluate structural reliability of degraded piping systems (Phase 2). Using these models, stochastic pipe fracture evaluation will be conducted for applications to leak-rate detection of piping in boiling water reactor and pressurized water reactor plants (Phase 3)

  3. Sodium fire tests for investigating the sodium leak in Monju

    International Nuclear Information System (INIS)

    As a part of the work for investigating the sodium leak accident which occurred in Monju on December 8, 1995, three tests, (1) sodium leak test, (2) sodium fire test-I, and (3) sodium fire test-II, were carried out at OEC/PNC. Main objectives of these tests are to confirm leak and burning behavior of sodium from the damaged thermometer, and effects of the sodium fire on integrity of the surrounding structure, etc. The main conclusions obtained from the tests are shown as below. 1) Average sodium leak rate obtained from the sodium leak test was about 50 g/sec. This was equivalent to the value estimated from level change in the sodium overflow tank in the Monju accident. 2) Observation from video cameras in the sodium fire tests revealed that in early stages of sodium leak, sodium dropped down out of the flexible tube of thermometer in drips. This dripping and burning were expanded in range as sodium splashed on the duct. 3) Though, in the sodium fire test-I, there was a decrease of about 1 mm at a thickness of the burning pan in the vicinity in just under in the leak point, there were completely no crack and failure. In the meantime, in the sodium fire test-II the six open holes were found in the floor liner. By this liner failure, the reaction between sodium and concrete might take place. At present, while the detailed evaluation on the sodium fire test-II has been mainly carried out, the investigation for clarifying the cause of the liner failure has been also carried out. (author)

  4. Correlative imaging in detecting post renal transplant urine leak

    International Nuclear Information System (INIS)

    Post transplant urinary leak is a common complication after kidney transplantation. There is no consensus on its most appropriate diagnostic and therapeutic methods. The objective of this study is to evaluate multiple imaging modalities in detecting symptomatic and asymptomatic urine leak. Seventeen cases of proven urine leak after renal transplantation were encountered and treated in our institution between November 1993 and September 2001. Diagnosis was made 7 to 41 days post transplantation. Ten cases were symptomatic and seven asymptomatic. Ultrasonography and radionuclide renography were performed for all patients. Contrast cystography was also performed in 7 patients. Radionuclide renography was obtained after injection of 10 mCi (370 MBq) of Tc99m-MAG-3. Flow study was acquired every one second for 60 seconds followed by sequential images obtained every 30 seconds for 29 minutes. Post void static image was then obtained. All studies were obtained while the urethral catheter is clamped to enhance the yield of the studies. Sixteen out of the 17 cases of leak were detected by radionuclide renography while only 8 were detected by ultrasonography. Among the 7 cases who had cystography leak was diagnosed in only 3. The case that was not detected by renography, was not detected by ultrasonography, was diagnosed by analyzing the wound leaky fluid in the laboratory and was further confirmed when treated surgically. Among the 7 asymptomatic cases only 3 had positive ultrasound findings while all were positive by radionuclide renography. Additionally, the findings of peri graft- fluid collections on ultrasonography were not as specific as those of the radionuclide renography for urine leak.Our experience suggests that radionuclide renography with clamping the urethral catheter is the modality of choice to detect both symptomatic and asymptomatic post renal transplant urine leak. (authors)

  5. Antiphospholipid Syndrome

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Antiphospholipid Syndrome Information Page Synonym(s): Hughes Syndrome Table of Contents ( ... research is being done? Clinical Trials What is Antiphospholipid Syndrome? Antiphospholipid syndrome (APS) is an autoimmune disorder caused ...

  6. "Getting the best sensitivity from on-capillary fluorescence detection in capillary electrophoresis" - A tutorial.

    Science.gov (United States)

    Galievsky, Victor A; Stasheuski, Alexander S; Krylov, Sergey N

    2016-09-01

    Capillary electrophoresis with Laser-Induced Fluorescence (CE-LIF) detection is being applied to new analytical problems which challenge both the power of CE separation and the sensitivity of LIF detection. On-capillary LIF detection is much more practical than post-capillary detection in a sheath-flow cell. Therefore, commercial CE instruments utilize solely on-capillary CE-LIF detection with a Limit of Detection (LOD) in the nM range, while there are multiple applications of CE-LIF that require pM or lower LODs. This tutorial analyzes all aspects of on-capillary LIF detection in CE in an attempt to identify means for improving LOD of CE-LIF with on-capillary detection. We consider principles of signal enhancement and noise reduction, as well as relevant areas of fluorophore photochemistry and fluorescent microscopy. PMID:27543015

  7. Full scale leak test of the MEGAPIE containment hull

    International Nuclear Information System (INIS)

    The Full Scale Leak Test (FSLT) experiment is designed to replicate an accidental leak of Lead-Bismuth Eutectic (LBE) liquid metal from the MEGAPIE neutron spallation source. The neutron source is totally encased in an aluminum containment hull cooled by heavy water. Any liquid metal which would, in a hypothetical accident, leak into the helium-filled insulation gap between the source and the aluminum containment hull, would immediately impact the hull. Furthermore, during irradiation in the PSI SINQ facility, the LBE in the MEGAPIE Lower Liquid Metal Container (LLMC) accumulates radio-active substances which, in the event of a leak, must be cooled and contained under controlled conditions, as they may otherwise contaminate the facility. The FSLT experiment has been devised to fully test the structural integrity of the containment hull against a sudden liquid metal leak, and in addition, to resolve the peak temperature of he coolant, to validate the sensors used in detecting a leak and of proof-test the analytical methods used in predicting the consequences of a leak. The FSLT experiment has been analysed ahead of the test, and both thermal and structural aspects calculated using commercial codes. The predictions applied conservative assumptions to the analysis of the thermal shock so as to preclude the likelihood of an unforeseen failure of the hull. In this document, these initial predictions are compared to the temperature and strain data recorded in the experiment. Further analysis, to be published at a later stage, will focus on applying actual conditions realised in the experiment, as opposed to the envelope case used in the test predictions. The integrity of the containment hull under loads resulting from liquid metal-leak is therefore the focal point of the experiment described in the current document, and serves as a key reference test for the Iicensing of the facility. The data recorded during the SLT experiment shows that the MEGAPIE containment hull is

  8. Full scale leak test of the MEGAPIE containment hull

    Energy Technology Data Exchange (ETDEWEB)

    Samec, K

    2006-07-15

    The Full Scale Leak Test (FSLT) experiment is designed to replicate an accidental leak of Lead-Bismuth Eutectic (LBE) liquid metal from the MEGAPIE neutron spallation source. The neutron source is totally encased in an aluminum containment hull cooled by heavy water. Any liquid metal which would, in a hypothetical accident, leak into the helium-filled insulation gap between the source and the aluminum containment hull, would immediately impact the hull. Furthermore, during irradiation in the PSI SINQ facility, the LBE in the MEGAPIE Lower Liquid Metal Container (LLMC) accumulates radio-active substances which, in the event of a leak, must be cooled and contained under controlled conditions, as they may otherwise contaminate the facility. The FSLT experiment has been devised to fully test the structural integrity of the containment hull against a sudden liquid metal leak, and in addition, to resolve the peak temperature of he coolant, to validate the sensors used in detecting a leak and of proof-test the analytical methods used in predicting the consequences of a leak. The FSLT experiment has been analysed ahead of the test, and both thermal and structural aspects calculated using commercial codes. The predictions applied conservative assumptions to the analysis of the thermal shock so as to preclude the likelihood of an unforeseen failure of the hull. In this document, these initial predictions are compared to the temperature and strain data recorded in the experiment. Further analysis, to be published at a later stage, will focus on applying actual conditions realised in the experiment, as opposed to the envelope case used in the test predictions. The integrity of the containment hull under loads resulting from liquid metal-leak is therefore the focal point of the experiment described in the current document, and serves as a key reference test for the Iicensing of the facility. The data recorded during the SLT experiment shows that the MEGAPIE containment hull is

  9. Prediction of Gas Leak Tightness of Superplastically Formed Products

    Science.gov (United States)

    Snippe, Corijn H. C.; Meinders, T.

    2010-06-01

    In some applications, in this case an aluminium box in a subatomic particle detector containing highly sensitive detecting devices, it is important that a formed sheet should show no gas leak from one side to the other. In order to prevent a trial-and-error procedure to make this leak tight box, a method is set up to predict if a formed sheet conforms to the maximum leak constraint. The technique of superplastic forming (SPF) is used in order to attain very high plastic strains before failure. Since only a few of these boxes are needed, this makes, this generally slow, process an attractive production method. To predict the gas leak of a superplastically formed aluminium sheet in an accurate way, finite element simulations are used in combination with a user-defined material model. This constitutive model couples the leak rate with the void volume fraction. This void volume fraction is then dependent on both the equivalent plastic strain and the applied hydrostatic pressure during the bulge process (backpressure).

  10. Leak-before-break behaviour of nuclear piping systems

    International Nuclear Information System (INIS)

    The general concept for break preclusion of nuclear piping systems in the FRG consists of two main prerequisites: Basic safety; independent redundancies. The leak-before-break behaviour is open of these redundancies and will be verified by fracture mechanics. The following items have to be evaluated: The growth of detected and postulated defects must be negligible in one life time of the plant; the growth behaviour beyond design (i.e. multiple load collectives are taken into account) leads to a stable leak; This leakage of the piping must be detected by an adequate leak detection system long before the critical defect size is reached. The fracture mechanics calculations concerning growth and instability of the relevant defects and corresponding leakage areas are described in more detail. The leak-before-break behaviour is shown for two examples of nuclear piping systems in pressurized water reactors: main coolant line of SIEMENS-PWR 1300 MW (ferritic material, diameter 800 mm); surge line of Russian WWER 440 (austenitic material, diameter 250 mm). The main results are given taking into account the relevant leak detection possibilities. (author). 9 refs, 9 figs

  11. Reducing gastrointestinal anastomotic leak rates: review of challenges and solutions

    Directory of Open Access Journals (Sweden)

    Phillips BR

    2016-01-01

    Full Text Available Benjamin R Phillips Department of Surgery, Division of Colon and Rectal Surgery, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA Abstract: Various techniques and interventions have been developed in an effort to obviate gastrointestinal anastomotic leaks. This review is intended to delineate potential modifications that can be made to reduce the risk of anastomotic leaks following gastrointestinal surgery. It may also serve to aid in identifying patients who are at increased risk of anastomotic leak. Modifiable risk factors for leak discussed include malnutrition, smoking, steroid use, bowel preparation, chemotherapy, duration of surgery, use of pressors, intravenous fluid administration, blood transfusion, and surgical anastomotic technique. Based upon literature review, operative techniques should include minimizing operative time, reducing ischemia, and utilizing stapled anastomoses. Buttressing of anastomoses with omentum has proven utility for esophageal surgery. Further recommendations include 5–7 days of immune-modifying nutritional supplementation for malnourished patients, discontinuation of smoking in the perioperative period, limiting steroid use, utilization of oral antibiotic preparation for colorectal surgery, avoidance of early operations (<4 weeks following chemotherapy, limiting pressor use, and the utilization of goal-directed fluid management. Keywords: anastomosis, anastomotic, leak, dehiscence, gastrointestinal, complications

  12. Development of leak analysis programs from through-wall-crack

    International Nuclear Information System (INIS)

    To introduce Leak-Before-Break (LBB) concept into the piping design standard of the LWR pressure boundary piping, LBB research programs are actively conducted in many nuclear electricity countries. It is one of the most important items to evaluate leak rate through the pipe wall crack to shut down a nuclear power plant safely. At JAERI, a test on the leak rate from a cracked pipe under BWR or PWR operating condition has been carried out from 1987 till 1989. This test is planned to measure the leak flow through circumferential fatigue cracks in 4-, 6-and, 12-inch diameter pipes and through slit specimens. On the other hands, it is necessary to predict and analyse the leak flow through a crack for applying the result of the tests to the structural design standard including the LBB concept. This report describes the some computer programs that calculate crack-opening-area, the crack length, and the flow rate through SCC or fatigue cracks. In these programs, a crack-opening-displacement calculation is available based on modified Tada-Paris equation when pipe geometries and pipe stress conditions are given. The leakage rate calculation is based on Henry's homogeneous nonequilibrium critical flow model and Moody's slip model with several modifications to account for friction and fluid conditions. (author)

  13. CEGB research on boiler leaks and their detection in service

    International Nuclear Information System (INIS)

    The penalty in loss of output to an electricity generation organisation as a consequence of failure to deal effectively with small LMFBR boiler leaks would be large. There is therefore a considerable incentive for these organisations to satisfy themselves that proper provisions are made to ensure that both the incidence and the severity of boiler leaks are minimised. In the UK, responsibility for the research, development and design work for this and indeed for most aspects of future nuclear power plant rests with the UKAEA and NPC; nevertheless as a consequence of its 'informed operator' policy the Central Electricity Generating Board has devoted some research effort to this field in recent years. o date, research work has been put in hand with the objective of achieving an understanding of the basic behaviour of boiler leaks. In addition, attention has been given to leak detection by monitoring the sodium for increases in oxygen and hydrogen levels. In both cases leaks into liquid sodium rather than into the gas space have been considered. In the course of the work hydrogen and oxygen meters based on the galvanic cell principle have been constructed and evaluated. The former is a new device which is comparable in performance with hydrogen meters based on the ion pump. The present state of the work is briefly described in this paper

  14. Capillary electrochromatography using fibers as stationary phases.

    Science.gov (United States)

    Jinno, K; Watanabe, H; Saito, Y; Takeichi, T

    2001-10-01

    Fiber-packed capillary columns have been evaluated in chromatographic performance in capillary electrochromatography (CEC). The change of electroosmotic flow (EOF) velocity and selectivity using different kinds of fiber materials was examined. Although the EOF velocity among the different fiber packed columns was almost the same, retention of parabens was larger on the Kevlar-packed column than on the Zylon-packed one, and was larger on the as-span-type fiber-packed column than on the high-modulus-type packed one. Using 200 microm ID x 5 cm Kevlar packed column combined with a 100 microm ID x 20 cm precolumn capillary and a 530 microm ID x 45 cm postcolumn capillary, the separation of three parabens within 30 s was achieved. Other compounds were also separated in a few minutes by the fiber-packed CEC method. PMID:11669512

  15. Uptake of water droplets by nonwetting capillaries

    CERN Document Server

    Willmott, Geoff R; Hendy, Shaun C

    2010-01-01

    We present direct experimental evidence that water droplets can spontaneously penetrate non-wetting capillaries, driven by the action of Laplace pressure due to high droplet curvature. Using high-speed optical imaging, microcapillaries of radius 50 to 150 micron, and water microdroplets of average radius between 100 and 1900 micron, we demonstrate that there is a critical droplet radius below which water droplets can be taken up by hydrophobised glass and polytetrafluoroethylene (PTFE) capillaries. The rate of capillary uptake is shown to depend strongly on droplet size, with smaller droplets being absorbed more quickly. Droplet size is also shown to influence meniscus motion in a pre-filled non-wetting capillary, and quantitative measurements of this effect result in a derived water-PTFE static contact angle between 96 degrees and 114 degrees. Our measurements confirm recent theoretical predictions and simulations for metal nanodroplets penetrating carbon nanotubes (CNTs). The results are relevant to a wide ...

  16. CO2-Leaking Well - Analytical Modeling

    Science.gov (United States)

    Wertz, F.; Audigane, P.; Bouc, O.

    2009-04-01

    The long-term integrity of CO2 storage in geological system relies highly on local trapping mechanisms but also on the absence/control of any kind of outlets. Indeed numerous pathways (faults, wells, rock heterogeneities…) exist that can lead stored gas back to the surface. Thus, such leakage risks must be assessed and quantified if possible. In France, BRGM is inquired for evaluating safety criteria and developing a methodology for qualifying potential geological storage sites. This implies in particular to study the leakage scenario, here through a water-filled well as a worth scenario case. In order to determine the kinds of impacts leaking CO2 can have; knowing the velocity and flow rate of uprising CO2 is a necessity. That is why a better knowledge of CO2 in storage conditions and its behaviour with the environment is required. The following study aims at characterising the CO2 flowing into the well and then rising up in a water column over the vertical dimension. An analytical model was built that describes: - In a first step, the CO2 flow between the reservoir and the inside of the well, depending on quality and thickness of different seals, which determines the flow rate through the well. - In a second step, the CO2 uprising through an open and water filled well, however in steady state, which excludes a priori the characterisation of periodic or chaotic behaviours such as geyser formation. The objective is to give numerous orders of magnitude concerning CO2 thermodynamic properties while rising up: specific enthalpy, density, viscosity, velocity, flow, gas volume fraction and expansion, pressure and temperature gradient. Dissolution is partially taken into account, however without kinetic. The strength of this model is to compute analytically - easily and instantaneously - the 1-dimensional rising velocity of CO2 in a water column as a function of the CO2 density, interfacial tension and initial volume fraction. Characteristic speeds - the ones given by

  17. Capillary Electrophoresis coupled with Automated Fraction Collection

    OpenAIRE

    Huge, Bonnie Jaskowski; Flaherty, Ryan; Dada, Oluwatosin O.; Dovichi, Norman J.

    2014-01-01

    A fraction collector based on a drop-on-demand ink-jet printer was developed to interface capillary zone electrophoresis with a 96 well microtiter plate. We first evaluated the performance of the collector by using capillary zone electrophoresis to analyze a 1 mM solution of tetramethylrhodamine; a fluorescent microtiter plate reader was then used to detect the analyte and characterize fraction carryover between wells. Relative standard deviation in peak height was 20% and the relative standa...

  18. The capillary electrophoresis of the influenza viruses

    Czech Academy of Sciences Publication Activity Database

    Horká, Marie; Kubesová, Anna; Kubíček, O.; Kubíčková, Z.; Rosenbergová, K.; Šlais, Karel

    Tallinn: Tallinn University of Technology, 2009 - (Borissova, M.; Vaher, M.). s. 93 ISBN 978-9985-59-930-3. [Nordic Separation Science Society (NoSSS) International Conference /5./. 26.08.2009-29.08.2009, Tallinn] R&D Projects: GA AV ČR IAAX00310701 Institutional research plan: CEZ:AV0Z40310501 Keywords : capillary isoelectric focusing * capillary electrophoresis * influenza swine and equine viruses Subject RIV: CB - Analytical Chemistry, Separation

  19. Selectivity and detection in capillary electrophoresis

    OpenAIRE

    Khaled, Maha Yehia

    1994-01-01

    This work is a contribution to the minimization of some of the selectivity and detection limitations in capillary electrophoresis. A more practical design of an electrochemical detector is introduced with simultaneous on-line UV detection (1), for the selective detection of a number of pungent and neurological compounds, the piperines and the capsacinoids. Commercially available microelectrodes together with large 25 μm id fused silica capillary columns are used for the fir...

  20. Posttraumatic bile leaks: role of diagnostic imaging and impact on patient outcome.

    Science.gov (United States)

    Fleming, Keith W; Lucey, Brian C; Soto, Jorge A; Oates, M Elizabeth

    2006-03-01

    The aim of this study was to evaluate the impact of bile leaks on patient morbidity and hospital course following blunt and penetrating liver trauma. Forty patients who underwent hepatobiliary scintigraphy after trauma were included. Scintigraphic results were classified as follows: free intraperitoneal bile leak, contained bile leak, and no bile leak. Outcomes measured were length of hospital stay, number of procedures required, and number of subsequent imaging studies. Bile leaks were identified in 25% of patients. Eight percent had free intraperitoneal leaks, 18% contained bile leaks, and 73% had no bile leak. One study was nondiagnostic due to poor hepatic function. Mean hospitalization was as follows: free bile leak group, 53 days; contained bile leak group, 10 days; no bile leak group, 14 days. Patients with free intraperitoneal bile leak had more imaging studies and procedures than patients without free bile leak. Patients with liver injury and free intraperitoneal bile leak have longer hospitalizations and undergo more therapeutic procedures than those without, who respond to conservative management. PMID:16369810

  1. Bruce unit 1 moderator to end shield cooling leak repairs

    International Nuclear Information System (INIS)

    In October 1994, a leak developed between the heavy water Moderator System and the light water End Shield Cooling System at Ontario Hydro's Bruce A Generating Station Unit 1. The interface between these two systems consists of numerous reactor components all within the reactor vessel. This paper describes the initial discovery and determination of the leak source. The techniques used to pinpoint the leak location are described. The repair strategies and details are outlined. Flushing and refilling of the Moderator system are discussed. The current status of the Unit 1 End Shield Cooling System is given with possible remedial measures for clean-up. Recommendations and observations are provided for future references. (author). 7 figs

  2. Gas-leak localization using distributed ultrasonic sensors

    Science.gov (United States)

    Huseynov, Javid; Baliga, Shankar; Dillencourt, Michael; Bic, Lubomir; Bagherzadeh, Nader

    2009-03-01

    We propose an ultrasonic gas leak localization system based on a distributed network of sensors. The system deploys highly sensitive miniature Micro-Electro-Mechanical Systems (MEMS) microphones and uses a suite of energy-decay (ED) and time-delay of arrival (TDOA) algorithms for localizing a source of a gas leak. Statistical tools such as the maximum likelihood (ML) and the least squares (LS) estimators are used for approximating the source location when closed-form solutions fail in the presence of ambient background nuisance and inherent electronic noise. The proposed localization algorithms were implemented and tested using a Java-based simulation platform connected to four or more distributed MEMS microphones observing a broadband nitrogen leak from an orifice. The performance of centralized and decentralized algorithms under ED and TDOA schemes is analyzed and compared in terms of communication overhead and accuracy in presence of additive white Gaussian noise (AWGN).

  3. Failure development in leaking LWR fuel rods - a literature survey

    International Nuclear Information System (INIS)

    This review of failure development is based largely on a literature survey up by some personal interpretation and judgement where conflicting evidence appears to exist. A brief review of known causes of defects in LWR fuel rods is included. Primary defects in fuel rods may not be single, isolated, leak sites, PCI defects being a classical example where very many penetrating cracks can form in a single fuel rod. The only secondary defect mechanism is internal hydriding, although knock-on events can follow on the same, or neighbouring rods, from defects that cause and interference with local coolant flow. The major part of this survey comprises information on leak rates from typical defects, causes and rates of development of primary leak sites, meachanisms and rates of development of secondary hydride defects and analysis of activity release measurements in an attempt to characterise the number and severity of defects present

  4. Natural air leak test without submergence for spontaneous pneumothorax

    Directory of Open Access Journals (Sweden)

    Uramoto Hidetaka

    2011-12-01

    Full Text Available Abstract Background Postoperative air leaks are frequent complications after surgery for a spontaneous pneumothorax (SP. We herein describe a new method to test for air leaks by using a transparent film and thoracic tube in a closed system. Method Between 2005 and 2010, 35 patients underwent a novel method for evaluating air leaks without submergence, and their clinical records were retrospectively reviewed. The data on patient characteristics, surgical details, and perioperative outcomes were analyzed. Results The differences in the clinical background and intraoperative factors did not reach a statistically significant level between the new and classical methods. The incidence of recurrence was also equivalent to the standard method. However, the length of the operation and drainage periods were significantly shorter in patients evaluated using the new method than the conventional method. Further, no postoperative complications were observed in patients evaluated using the new method. Conclusions This simple technique is satisfactorily effective and does not result in any complications.

  5. An electrical method for the early detection of sodium leaks

    International Nuclear Information System (INIS)

    The development and performance of a simple electrical method for the early detection of sodium leaks is described. The basis of the method is to wrap the pipework or vessel in sections with a current-carrying electric cable insulated from the pipework by a material pervious to sodium. The pipework is earthed and the earth leakage current is continuously monitored using a conventional earth leakage circuit breaker. In the event of a leak sodium will encounter the conductor and a current with flow to earth. The current trips the detector and operates a relay which can sound an alarm and indicate the section of the rig where the fault is located on a mimic diagram. The system, which has been in use on experimental facilities for several years, is capable of detecting a leak of 2g Na in 20 sec. The same cable can be used for trace-heating. (U.K.)

  6. Integrated leak rate test results of JOYO reactor containment vessel

    International Nuclear Information System (INIS)

    Integrated leak rate tests of JOYO after the reactor coolant system had been filled with sodium have been performed two times since 1978 (February 1978 and December 1979). The tests were conducted with the in-containment sodium systems, primary argon cover gas system and air conditioning systems operating. Both the absolute pressure method and the reference chamber method were employed during the test. The results of both tests confirmed the functioning of the containment vessel, and leak rate limits were satisfied. In Addition, the adequancy of the test instrumentation system and the test method was demonstrated. Finally the plant conditions required to maintain reasonable accuracy for the leak rate testing of LMFBR were established. In this paper, the test conditions and the test results are described. (author)

  7. Leak and condition evaluation of a buried aqueduct

    Science.gov (United States)

    Maser, Kenneth R.; Zarghamee, Medhi S.

    1998-03-01

    A leak survey of a major metropolitan area aqueduct was carried out using a combination of infrared thermography, ground penetrating radar (GPR), and ultrasonic techniques. The objective of the infrared survey was to investigate the entire length of the aqueduct in order to reveal possible leak conditions which would not be observable by other means. The objective of the GPR survey was to focus attention more locally on key areas such as known leak locations, proposed test pit locations, and areas which were identified from the infrared survey. The ultrasonic tests were carried out on the concrete wall of the aqueduct when it was exposed for detailed evaluation. The infrared survey was carried out from a helicopter, and covered the entire 16 mile length of the aqueduct. The GPR survey was carried longitudinally on 20665 linear feet of the aqueduct (26% of the total near surface length), and transversely at 89 different stations. The ultrasonic tests were carried out in 8 excavated test pits. The analysis of the infrared and GPR survey results revealed that: (1) of the 25 documented leaks surveyed, 13 were confirmed, 9 show no evidence of leakage, and 3 could not be evaluated; (2) 35 additional sites have indications of possible leakage; (3) the soil cover in one area far exceeds the anticipated design conditions; (4) the soil conductivity is high (i.e., corrosion is likely) in 9 areas, 6 of which surround or are close to documented leak sites; and (5) there is a major leakage channel along the side of the pipe caused by one of the leaks. The results of the ultrasonic testing revealed occasional delamination between the structural wall of the aqueduct and the inner steel lining.

  8. High Altitude Aerial Natural Gas Leak Detection System

    Energy Technology Data Exchange (ETDEWEB)

    Richard T. Wainner; Mickey B. Frish; B. David Green; Matthew C. Laderer; Mark G. Allen; Joseph R. Morency

    2006-12-31

    The objective of this program was to develop and demonstrate a cost-effective and power-efficient advanced standoff sensing technology able to detect and quantify, from a high-altitude (> 10,000 ft) aircraft, natural gas leaking from a high-pressure pipeline. The advanced technology is based on an enhanced version of the Remote Methane Leak Detector (RMLD) platform developed previously by Physical Sciences Inc. (PSI). The RMLD combines a telecommunications-style diode laser, fiber-optic components, and low-cost DSP electronics with the well-understood principles of Wavelength Modulation Spectroscopy (WMS), to indicate the presence of natural gas located between the operator and a topographic target. The transceiver transmits a laser beam onto a topographic target and receives some of the laser light reflected by the target. The controller processes the received light signal to deduce the amount of methane in the laser's path. For use in the airborne platform, we modified three aspects of the RMLD, by: (1) inserting an Erbium-doped optical fiber laser amplifier to increase the transmitted laser power from 10 mW to 5W; (2) increasing the optical receiver diameter from 10 cm to 25 cm; and (3) altering the laser wavelength from 1653 nm to 1618 nm. The modified RMLD system provides a path-integrated methane concentration sensitivity {approx}5000 ppm-m, sufficient to detect the presence of a leak from a high capacity transmission line while discriminating against attenuation by ambient methane. In ground-based simulations of the aerial leak detection scenario, we demonstrated the ability to measure methane leaks within the laser beam path when it illuminates a topographic target 2000 m away. We also demonstrated simulated leak detection from ranges of 200 m using the 25 cm optical receiver without the fiber amplifier.

  9. Containment leak-tightness enhancement at VVER 440 NPPs

    International Nuclear Information System (INIS)

    The hermetic compartments of VVER 440 NPPs fulfil the function of the containment used at NPPs all over the word. The purpose of the containment is to protect the NPP personal against radioactive impact as well as to prevent radioactive leakage to the environment during a lost of coolant accident. Leak-tightness enhancement in NPPs with VVER 440/213 and VVER 440/230 reactors is an important safety issue. New procedures, measures and methods were adopted at NPPs in Mochovce, J. Bohunice, Dukovany and Paks for leak identification and sealing works performed by VUEZ Levice. (authors)

  10. Development of leak rate calculation model and code in piping

    International Nuclear Information System (INIS)

    Background: With the development of fracture mechanics, Leak-Before-Break (LBB) is widely used in nuclear power plant piping design. Purpose: In order to support the application of LBB, leak rate through crack need to be calculated. Methods: In this text, an analytical flow model is developed based on homogeneous non-equilibrium model, a computer program is also developed based on this analytical model. Results: Comparison between the results from the above program and test results shows that deviations of calc. results to test results are within ±50%. Conclusions: Conclusions can be got that this analytical model and computer program meet the requirement of engineering application. (authors)

  11. Elderly patient with ureteric colic: suspect leaking aneurysm

    OpenAIRE

    Sinha, Yashashwi

    2013-01-01

    Described below is a case of a 72-year-old man with an abdominal aortic aneurysm (AAA) presenting with symptoms of renal colic. This case illustrates the hazards of making a diagnosis of renal colic in an elderly patient without considering the diagnosis of a leaking AAA. The diagnosis of an AAA can be challenging and renal colic is the single most common misdiagnosis. The patient's initial presentation can be misleading as symptoms fit the features of renal colic or a leaking AAA. Despite no...

  12. HUMOS monitoring system of leaks into the containment atmosphere

    International Nuclear Information System (INIS)

    The detection and monitoring of coolant leaks into the containment atmosphere during reactor operation is a major safety measure. Using the HUMOS monitoring system, leaks can be detected in pressure tests of integrity and in any other mode of operation when the reactor ventilation system is operating and the primary circuit and its components are pressurized. Performance tests, the design, hardware and software of the HUMOS system are briefly described. A test was performed to demonstrate that a small amount of humidity released by leakage into the containment air can be detected. (M.D.)

  13. External detection and localization of well leaks in aquifer zones

    Science.gov (United States)

    Haas, Allan K.

    This dissertation presents a new methodology for monitoring, detecting, and localizing shallow, aquifer zone leaks in oil and gas wells. The rationale for this type of leak detection is to close the knowledge gap associated with public claims of subsurface water resource contamination caused by the oil and gas industry. A knowledge gap exists because there is no data, one way or the other, that can definitively prove or deny the existence of subsurface leakage pathways in oil and gas wells, new, old or abandoned. This dissertation begins with an overview of existing and future oil and gas well leak detection methods, and then presents three published papers, each describing a different phenomena that can be exploited for leak monitoring, detection, localization, and damage extent determination. The first paper describes the direct detection and localization of a leak that was discovered during a laboratory based hydraulic fracturing experiment. The second paper describes the laboratory measured electrical response that occurs during two phase flow inside of porous media. The third paper describes the detection and tracking of a gravity driven salt plume leak in a freshwater test tank in the laboratory. the three geophysical approaches that are presented, when combined together, provide a new, powerful, external to the well method to monitor, detect, localize, and assess the damage from leaks in the drinking water protection zone of oil and gas wells. This is a capability that is not available in any other leak detection and localization method. This dissertation also presents a chapter of Science, Technology and Society (STS), and Science, and Technology Policy (STP) as a final fulfillment requirement of the SmartGeo Fellowship program, and the Science, Technology, Engineering, and Policy minor. This chapter introduces a new STS/STP concept concerning the after effects of knowledge boundary disputes. This new concept is called the residual footprints of knowledge

  14. Strength and leak testing of plasma activated bonded interfaces

    DEFF Research Database (Denmark)

    Visser, M.M.; Weichel, Steen; Reus, Roger De;

    2002-01-01

    Bond strength and hermeticity of plasma activated bonded (PAB) Si-Si interfaces are reported. Bonding of 100 mm Si(1 0 0) wafers was performed. An average bond strength of 9.0+/-3.9 MPa was achieved without performing any annealing steps. Cavities bonded in vacuum were found to be hermetic based on...... detection of changes in membrane deflections. The detection limit for leak was 8E-13 mbar l/s. For comparison, strength and leak tests were also performed with regular fusion bonded wafers annealed at 1100 degreesC. The PAB was found to withstand post-processing steps such as RCA cleaning, 24 h in de...

  15. Leak before break application in French PWR plants under operation

    Energy Technology Data Exchange (ETDEWEB)

    Faidy, C. [EDF SEPTEN, Villeurbanne (France)

    1997-04-01

    Practical applications of the leak-before break concept are presently limited in French Pressurized Water Reactors (PWR) compared to Fast Breeder Reactors. Neithertheless, different fracture mechanic demonstrations have been done on different primary, auxiliary and secondary PWR piping systems based on similar requirements that the American NUREG 1061 specifications. The consequences of the success in different demonstrations are still in discussion to be included in the global safety assessment of the plants, such as the consequences on in-service inspections, leak detection systems, support optimization,.... A large research and development program, realized in different co-operative agreements, completes the general approach.

  16. Wide-band gas leak imaging detection system using UFPA

    Science.gov (United States)

    Jin, Wei-qi; Li, Jia-kun; Dun, Xiong; Jin, Minglei; Wang, Xia

    2014-11-01

    The leakage of toxic or hazardous gases not only pollutes the environment, but also threatens people's lives and property safety. Many countries attach great importance to the rapid and effective gas leak detection technology and instrument development. However, the gas leak imaging detection systems currently existing are generally limited to a narrow-band in Medium Wavelength Infrared (MWIR) or Long Wavelength Infrared (LWIR) cooled focal plane imaging, which is difficult to detect the common kinds of the leaking gases. Besides the costly cooled focal plane array is utilized, the application promotion is severely limited. To address this issue, a wide-band gas leak IR imaging detection system using Uncooled Focal Plane Array (UFPA) detector is proposed, which is composed of wide-band IR optical lens, sub-band filters and switching device, wide-band UFPA detector, video processing and system control circuit. A wide-band (3µm~12µm) UFPA detector is obtained by replacing the protection window and optimizing the structural parameters of the detector. A large relative aperture (F#=0.75) wide-band (3μm~12μm) multispectral IR lens is developed by using the focus compensation method, which combining the thickness of the narrow-band filters. The gas leak IR image quality and the detection sensitivity are improved by using the IR image Non-Uniformity Correction (NUC) technology and Digital Detail Enhancement (DDE) technology. The wide-band gas leak IR imaging detection system using UFPA detector takes full advantage of the wide-band (MWIR&LWIR) response characteristic of the UFPA detector and the digital image processing technology to provide the resulting gas leak video easy to be observed for the human eyes. Many kinds of gases, which are not visible to the naked eyes, can be sensitively detected and visualized. The designed system has many commendable advantages, such as scanning a wide range simultaneously, locating the leaking source quickly, visualizing the gas

  17. Catastrophic antiphospholipid Syndrome

    International Nuclear Information System (INIS)

    The antiphospholipid syndrome (APS) is characterized by venous, arterial thrombosis and miscarriages along with lupic anticoagulant and antibodies against anticardiolipin. The catastrophic antiphospholipid syndrome (CAPS) has been described since 1992 like a multiple organic dysfunction caused by multiple vascular thrombosis in three or more organs. The patients who suffer from this syndrome may have or not history of APS. There are two or three mechanisms that may cause the CAPS, alone or in combination: These are: 1. The multisystemic thrombotic disease with emphasis in microvasculature occlusion of the organs and occlusion of big arterial or veins 2. The disseminated intravascular coagulation (DIC) superimpose in 15% to 50% of the patients that, of course, conducted to an occlusive disease of arterioles, veins or capillaries. 3. A systemic inflammatory response syndrome (SIRS) induced by citoquines. In this review it is described clinical and laboratory features, pathogenesis and treatment of CAPS. For this purpose, it was searched for Medline from 1993 to 2000 and revised the most significant issues obtained by this medium

  18. Leak finder : new twist on fibre optics promises well-operators an ear for downhole gas leaks

    Energy Technology Data Exchange (ETDEWEB)

    Mahony, J.

    2010-04-15

    Alberta's Energy Resources Conservation Board (ERCB) requires that well operators report downhole gas leaks. Leaks fall into two groups, notably gas migration, where gas works its way to surface, usually outside the wellbore, through holes in the concrete around the casing; and surface casing vent flow, where gas moves up the wellbore, usually between the production casing and surface casing. The ERCB gauges the seriousness of the leak through a formula that considers well depth, gas pressure and flow rate. If deemed serious, a leak must be repaired within 90 days. If deemed non-serious, the operator need only monitor the casing vent flow for changes in pressure, volume or both. The greatest challenge is finding the leak. Until recently, the tools for the job were a microphone on a wireline. However, a new method that provides a faster, more accurate way of finding downhole gas leaks has been developed by Alberta-based HiFi Engineering. The method uses fibre optics as a sensor and as a transmission medium. The fibre is treated to effectively transform it into an acoustic sensor. After treatment, the fibre itself becomes the microphone and is highly sensitive to acoustics. The fibre can move data at the speed of light and can also sense very faint sounds in the wellbore, making it useful for tracing casing vent flows or gas migration through the noise produced. HiFi's soon to be commercialized fibre optic technology has been extensively tested in the laboratory. The distributed fibre optic acoustic sensors have also been tested on 4 Cenovus natural gas wells in Alberta. The signal-to-noise ratio is key to the usefulness of any sound-detection device. The sensitivity of the tool increases as the signal-to-noise ratio increases. 1 refs., 3 figs.

  19. Capillary fracture of soft gels.

    Science.gov (United States)

    Bostwick, Joshua B; Daniels, Karen E

    2013-10-01

    A liquid droplet resting on a soft gel substrate can deform that substrate to the point of material failure, whereby fractures develop on the gel surface that propagate outwards from the contact line in a starburst pattern. In this paper, we characterize (i) the initiation process, in which the number of arms in the starburst is controlled by the ratio of the surface tension contrast to the gel's elastic modulus, and (ii) the propagation dynamics showing that once fractures are initiated they propagate with a universal power law L[proportional]t(3/4). We develop a model for crack initiation by treating the gel as a linear elastic solid and computing the deformations within the substrate from the liquid-solid wetting forces. The elastic solution shows that both the location and the magnitude of the wetting forces are critical in providing a quantitative prediction for the number of fractures and, hence, an interpretation of the initiation of capillary fractures. This solution also reveals that the depth of the gel is an important factor in the fracture process, as it can help mitigate large surface tractions; this finding is confirmed with experiments. We then develop a model for crack propagation by considering the transport of an inviscid fluid into the fracture tip of an incompressible material and find that a simple energy-conservation argument can explain the observed material-independent power law. We compare predictions for both linear elastic and neo-Hookean solids, finding that the latter better explains the observed exponent. PMID:24229192

  20. A Study on the Evaluation of Valve Leak Rates Using Acoustic Emission Technique

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Guk; Lee, Jun Shin; Lee, Sun Ki; Shon, Seok Man; Lee, Wook Ryun; Kim, Tae Ryong [Korea Electric Power Research Institute, Taejon (Korea, Republic of); Lim, Yong Jae; Choo, Kee Young [Hana Evertech Co., Seongnam (Korea, Republic of)

    2005-07-01

    The objective of this study is to estimate the feasibility of acoustic emission method for the internal leak from the valves. In this study, two types of valve(a 3 1/2 inch glove valve for 600 psi steam and a 4 inch ball valve water ) leak tests using three different leak path and numerous leak rates were performed in order to analyze acoustic emission properties when leaks arise in valve seat. As a result of leak test for specimens simulated valve seat, we conformed that leak sound amplitude increased in proportion to the increase of leak rate, and leak rates were plotted versus peak acoustic amplitudes recorded within those two narrow frequency bands on each spectral plot. The resulting plots of leak rate versus peak acoustic amplitude were the primary basis for determining the feasibility of quantifying leak acoustically. The large amount of data collected also allowed a grief investigation of the effects of different leak paths, leakage rates, pressure differentials and transducers on the acoustic amplitude spectra. From the experimental results, it was suggested that the acoustic emission method for monitoring of leak was feasible.

  1. Use of capillary electrophoresis and indirect detection to quantitate in-capillary enzyme-catalyzed microreactions.

    Science.gov (United States)

    Zhang, Y; el-Maghrabi, M R; Gomez, F A

    2000-04-01

    The use of capillary electrophoresis and indirect detection to quantify reaction products of in-capillary enzyme-catalyzed microreactions is described. Migrating in a capillary under conditions of electrophoresis, plugs of enzyme and substrate are injected and allowed to react. Capillary electrophoresis is subsequently used to measure the extent of reaction. This technique is demonstrated using two model systems: the conversion of fructose-1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde-3-phosphate by fructose-biphosphate aldolase (ALD, EC 4.1.2.13), and the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate by fructose-1,6-bisphospatase (FBPase, EC 3.1.3.11). These procedures expand the use of the capillary as a microreactor and offer a new approach to analyzing enzyme-mediated reactions. PMID:10892022

  2. A Novel Polybrene/Chondroitin Sulfate C Double Coated Capillary and Its Application in Capillary Electrophoresis

    Institute of Scientific and Technical Information of China (English)

    DU,Ying-Xiang(杜迎翔); HONDA,Susumu; TAGA,Atsushi; LIU,Wen-Ying(刘文英); SUZUKI,Shigeo

    2002-01-01

    A new capillary coated by double polymer, polybrene/chondroitin sulfate C (P/CC), was developed using a simple procedure. The P/CC double coated capillary showed long lifetime,strong chemical stability and good reproducibility. It endured during more than 100 replicated analyses and was also tolerant to HCl (1 mol/L), NaOH (0.01 mol/L), CH3OH and CH3CN. The P/CC double coated capillary can be applied to basic drug analyses. The adsorption of basic drugs to the capillary wall was suppressed and the peak tailing greatly decreased. The use of the P/CC double coated capillary allowed excelent separation of the enantiomers of some basic drugs by using chondroitin sulfate C as the chiral selector, ami the peak symmetry of basic drugs was further improved under these conditions.

  3. Nanoparticle-based capillary electroseparation of proteins in polymer capillaries under physiological conditions

    DEFF Research Database (Denmark)

    Nilsson, C.; Harwigsson, I.; Becker, K.;

    2010-01-01

    of nanoparticles, i.e. in CE mode, the protein samples adsorbed completely to the capillary walls and could not be recovered. In contrast, nanoparticle-based capillary electroseparation resolved green fluorescent protein from several of its impurities within I min. Furthermore, a mixture of native green...... fluorescent protein and two of its single-amino-acid-substituted variants was separated within 2.5 min with efficiencies of 400 000 plates/m. The nanoparticles prevent adsorption by introducing a large interacting surface and by obstructing the attachment of the protein to the capillary wall. A one......Totally porous lipid-based liquid crystalline nanoparticles were used as pseudostationary phase for capillary electroseparation with LIF detection of proteins at physiological conditions using unmodified cyclic olefin copolymer capillaries (Topas (R), 6.7 cm effective length). In the absence...

  4. Capillary-Tube Model and Experiment of Multiphase Flow in Capillary Fringes

    Institute of Scientific and Technical Information of China (English)

    武晓峰; 唐杰; 吕贤弼

    2002-01-01

    Contamination of soil and groundwater by organic substances is causing more and more problems worldwide. Analysis of the movement and distribution of nonaqueous phase liquids (NAPLs) in subsurface domain is critical for contaminant remediation. Two-dimensional experiments were conducted in a transparent plexiglass trough (105.0 cm×70.0 cm×1.5 cm) to simulate the release and redistribution of gasoline and kerosene in porous media. The results show that before the contaminant distribution reaches equilibrium, the movement of light NAPLs (LNAPLs) can be divided into four sub-stages. After the contaminant front reaches the upper boundary of the capillary fringe, contaminant movement along the upper boundary of the capillary fringe is the primary transport process. Most of the contaminants then move into the capillary fringe except for the residual part. One-dimensional and two-dimensional capillary tube models were developed to analyze the movement of LNAPLs in the capillary fringe.

  5. Some factors affecting the valinomycin-induced leak from liposomes

    NARCIS (Netherlands)

    Blok, M.C.; Gier, J. de; Deenen, L.L.M. van

    1974-01-01

    Experiments dealing with the valinomycin-induced K+ leak from egg lecithin liposomes have demonstrated the importance of the enclosed anion. Except when lipophilic anions are enclosed, the addition of both valinomycin and a uncoupler, e.g. carbonylcyanide p-trifluoromethoxyphenylhydrazone, is necess

  6. New methods for leaks detection and localisation using acoustic emission

    International Nuclear Information System (INIS)

    Real time monitoring of Pressurized Water nuclear Reactor secondary coolant system tends to integrate digital processing machines. In this context, the method of acoustic emission seems to exhibit good performances. Its principle is based on passive listening of noises emitted by local micro-displacements inside a material under stress which propagate as elastic waves. The lack of a priori knowledge on leak signals leads us to go deeper into understanding flow induced noise generation. Our studies are conducted using a simple leak model depending on the geometry and the king of flow inside the slit. Detection and localization problems are formulated according to the maximum likelihood principle. For detection, the methods using a indicator of similarity (correlation, higher order correlation) seems to give better results than classical ones (rms value, envelope, filter banks). For leaks location, a large panel of classical (generalized inter-correlation) and innovative (convolution, adaptative, higher order statistics) methods of time delay estimation are presented. The last part deals with the applications of higher order statistics. The analysis of higher order estimators of a non linear non Gaussian stochastic process family, the improvement of non linear prediction performances and the optimal-order choice problem are addressed in simple analytic cases. At last, possible applications to leak signals analysis are pointed out. (authors).264 refs., 7 annexes

  7. Acoustic leak-detection system for railroad transportation security

    Science.gov (United States)

    Womble, P. C.; Spadaro, J.; Harrison, M. A.; Barzilov, A.; Harper, D.; Hopper, L.; Houchins, E.; Lemoff, B.; Martin, R.; McGrath, C.; Moore, R.; Novikov, I.; Paschal, J.; Rogers, S.

    2007-04-01

    Pressurized rail tank cars transport large volumes of volatile liquids and gases throughout the country, much of which is hazardous and/or flammable. These gases, once released in the atmosphere, can wreak havoc with the environment and local populations. We developed a system which can non-intrusively and non-invasively detect and locate pinhole-sized leaks in pressurized rail tank cars using acoustic sensors. The sound waves from a leak are produced by turbulence from the gas leaking to the atmosphere. For example, a 500 μm hole in an air tank pressurized to 689 kPa produces a broad audio frequency spectrum with a peak near 40 kHz. This signal is detectable at 10 meters with a sound pressure level of 25 dB. We are able to locate a leak source using triangulation techniques. The prototype of the system consists of a network of acoustic sensors and is located approximately 10 meters from the center of the rail-line. The prototype has two types of acoustic sensors, each with different narrow frequency response band: 40 kHz and 80 kHz. The prototype is connected to the Internet using WiFi (802.11g) transceiver and can be remotely operated from anywhere in the world. The paper discusses the construction, operation and performance of the system.

  8. Low-Leak, High-Flow Poppet Valve

    Science.gov (United States)

    Tervo, John N.

    1995-01-01

    Valve with conical poppet modified to incorporate smooth transition to segment of sphere at upstream end of cone. Constitutes sealing surface of poppet; results in leak rate equivalent to ball-type poppet, and extremely low flow losses. Also enables use of loose fit for guiding poppet, with resulting lower manufacturing cost, high reliability, and long operating life.

  9. A Hydrazine Leak Sensor Based on Chemically Reactive Thermistors

    Science.gov (United States)

    Davis, Dennis D.; Mast, Dion J.; Baker, David L.

    1999-01-01

    Leaks in the hydrazine supply system of the Shuttle APU can result in hydrazine ignition and fire in the aft compartment of the Shuttle. Indication of the location of a leak could provide valuable information required for operational decisions. WSTF has developed a small, single use sensor for detection of hydrazine leaks. The sensor is composed of a thermistor bead coated with copper(II) oxide (CuO) dispersed in a clay or alumina binder. The CuO-coated thermistor is one of a pair of closely located thermistors, the other being a reference. On exposure to hydrazine the CuO reacts exothermically with the hydrazine and increases the temperature of the coated-thermistor by several degrees. The temperature rise is sensed by a resistive bridge circuit and an alarm registered by data acquisition software. Responses of this sensor to humidity changes, hydrazine concentration, binder characteristics, distance from a liquid leak, and ambient pressure levels as well as application of this sensor concept to other fluids are presented.

  10. Monitoring plan for characterization of the Building 3019 leak site

    International Nuclear Information System (INIS)

    The Oak Ridge National Laboratory (ORNL) has established a Remedial Action Program to provide comprehensive management of areas where past research, development, and waste management activities have resulted in residual contamination of facilities or the environment. In the winter of 1985, elevated levels of strontium-90 were detected in White Oak Creek and the ORNL sewage treatment plant. A leak was subsequently identified in a low-level waste transfer line north of Building 3019. The period of leakage and the exact chemical composition of the effluent are unknown. Two dye tests conducted at the leak site have identified several possible pathways for contaminant migration. The discovery of a solution cavity in the Chickamauga bedrock underlying the leak site and the rapid appearance of dye in the sump at Building 3042 indicate the extension of the cavity system along strike to the east. This report outlines the available published and unpublished background information pertaining to the site and proposes a monitoring plan consisting of soil sample collection and monitor well installation to provide a preliminary assessment of the types and extent of contamination at the leak site. The plan is also designed to provide additional geologic and hydrologic data for evaluating possible contaminant migration pathways. 6 refs., 10 figs., 1 tab

  11. T Plant secondary containment and leak detection upgrades

    International Nuclear Information System (INIS)

    The W-259 project will provide upgrades to the 2706-T/TA Facility to comply with Federal and State of Washington environmental regulations for secondary containment and leak detection. The project provides decontamination activities supporting the environmental restoration mission and waste management operations on the Hanford Site

  12. Analyzing User Awareness of Privacy Data Leak in Mobile Applications

    Directory of Open Access Journals (Sweden)

    Youngho Kim

    2015-01-01

    Full Text Available To overcome the resource and computing power limitation of mobile devices in Internet of Things (IoT era, a cloud computing provides an effective platform without human intervention to build a resource-oriented security solution. However, existing malware detection methods are constrained by a vague situation of information leaks. The main goal of this paper is to measure a degree of hiding intention for the mobile application (app to keep its leaking activity invisible to the user. For real-world application test, we target Android applications, which unleash user privacy data. With the TaintDroid-ported emulator, we make experiments about the timing distance between user events and privacy leaks. Our experiments with Android apps downloaded from the Google Play show that most of leak cases are driven by user explicit events or implicit user involvement which make the user aware of the leakage. Those findings can assist a malware detection system in reducing the rate of false positive by considering malicious intentions. From the experiment, we understand better about app’s internal operations as well. As a case study, we also presents a cloud-based dynamic analysis framework to perform a traffic monitor.

  13. Gender Inequality at Universities and the ‘Leaking Pipeline’

    DEFF Research Database (Denmark)

    Emerek, Ruth; Larsen, Britt Østergaard

    2010-01-01

    Research shows that the correlation - the higher the level of academic positions at universities the lower the percentage of women among employees - also applies at Danish universities (Ståhle, 2007). This may be due to a historic back log or merely to a ’Leaking pipeline’, as earlier studies hav...

  14. The minimal leak test technique for endotracheal cuff maintenance.

    Science.gov (United States)

    DA, Harvie; Jn, Darvall; M, Dodd; A, De La Cruz; M, Tacey; Rl, D'Costa; D, Ward

    2016-09-01

    Endotracheal tube (ETT) cuff pressure management is an essential part of airway management in intubated and mechanically ventilated patients. Both under- and over-inflation of the ETT cuff can lead to patient complications, with an ideal pressure range of 20-30 cmH2O defined. A range of techniques are employed to ensure adequate ETT cuff inflation, with little comparative data. We performed an observational cross-sectional study in a tertiary metropolitan ICU, assessing the relationship between the minimal leak test and cuff manometry. Forty-five mechanically ventilated patients, over a three-month period, had ETT cuff manometry performed at the same time as their routine cuff maintenance (minimal leak test). Bedside nurse measurements were compared with investigator measurements. At the endpoint of cuff inflation, 20 of 45 patients (44%) had cuff pressures between 20 and 30 cmH2O; 11 of 45 patients (24%) had cuff pressures 2O; 14 of 45 patients (31%) had cuff pressures ≥30 cmH2O. Univariate analysis demonstrated an association between both patient obesity and female gender requiring less ETT cuff volume (P=0.008 and P cuff pressures. Inter-operator reliability in performing the minimal leak test showed no evidence of bias between nurse and investigators (Pearson coefficient = 0.897). We conclude the minimal leak test for maintenance of ETT cuffs leads to both over- and under-inflation, and alternative techniques, such as cuff manometry, should be employed. PMID:27608343

  15. 40 CFR 63.769 - Equipment leak standards.

    Science.gov (United States)

    2010-07-01

    ... operate for more than 30 days after a pressure release without monitoring. (2) For pressure relief devices...) For pressure relief devices, when a leak is detected, it shall be repaired as soon as practicable, but... devices in gas/vapor service that are located at a nonfractionating plant that does not have the...

  16. Demonstration of a persistent chyle leak using lymphoscintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Winstanley, S. [St. Vincent`s Hospital, Sydney, NSW (Australia). Department of Nuclear Medicine

    1998-03-01

    Full text: Lymphoscintigraphy has long been regarded as a non-invasive and cost efficient way of assessing the Iymphatic system. This case study of a 56-year-old woman demonstrates its usefulness in localising a chyle leak following an oesophagogastrectomy for oesophageal cancer. The patient was injected with 100 MBq of {sup 99}mTc-antimony colloid in the second and third web spaces of both feet. Images were obtained over several hours from the feet to the abdomen and chest, allowing the identification of normal Iymphatic drainage. The scan demonstrated abnormal accumulation of isotope in the chest, just above the diaphragm and relatively posteriorly. The patient subsequently underwent surgery at which time a thoracotomy and ligation of a leaking thoracic duct was performed. A second study was performed after a month due to continuing drainage of fluid from both the abdomen and chest, along with worsening oedema. These scans again demonstrated abnormal accumulation of tracer in the upper abdomen posteriorly which was interpreted as a Iymphatic leak. Subsequent surgery resulted in the insertion of a Denver shunt from the peritoneal cavity to the right saphenous vein. In conclusion, this case study demonstrates the usefulness of Iymphoscintigraphy in assessing the difficult problem of post-operative chyle leak.

  17. The capillary hysteresis model HYSTR: User's guide

    International Nuclear Information System (INIS)

    The potential disposal of nuclear waste in the unsaturated zone at Yucca Mountain, Nevada, has generated increased interest in the study of fluid flow through unsaturated media. In the near future, large-scale field tests will be conducted at the Yucca Mountain site, and work is now being done to design and analyze these tests. As part of these efforts a capillary hysteresis model has been developed. A computer program to calculate the hysteretic relationship between capillary pressure φ and liquid saturation (S1) has been written that is designed to be easily incorporated into any numerical unsaturated flow simulator that computes capillary pressure as a function of liquid saturation. This report gives a detailed description of the model along with information on how it can be interfaced with a transport code. Although the model was developed specifically for calculations related to nuclear waste disposal, it should be applicable to any capillary hysteresis problem for which the secondary and higher order scanning curves can be approximated from the first order scanning curves. HYSTR is a set of subroutines to calculate capillary pressure for a given liquid saturation under hysteretic conditions

  18. Synthetic Capillaries to Control Microscopic Blood Flow

    Science.gov (United States)

    Sarveswaran, K.; Kurz, V.; Dong, Z.; Tanaka, T.; Penny, S.; Timp, G.

    2016-02-01

    Capillaries pervade human physiology. The mean intercapillary distance is only about 100 μm in human tissue, which indicates the extent of nutrient diffusion. In engineered tissue the lack of capillaries, along with the associated perfusion, is problematic because it leads to hypoxic stress and necrosis. However, a capillary is not easy to engineer due to its complex cytoarchitecture. Here, it is shown that it is possible to create in vitro, in about 30 min, a tubular microenvironment with an elastic modulus and porosity consistent with human tissue that functionally mimicks a bona fide capillary using “live cell lithography”(LCL) to control the type and position of cells on a composite hydrogel scaffold. Furthermore, it is established that these constructs support the forces associated with blood flow, and produce nutrient gradients similar to those measured in vivo. With LCL, capillaries can be constructed with single cell precision—no other method for tissue engineering offers such precision. Since the time required for assembly scales with the number of cells, this method is likely to be adapted first to create minimal functional units of human tissue that constitute organs, consisting of a heterogeneous population of 100-1000 cells, organized hierarchically to express a predictable function.

  19. EUV radiation from nitrogen capillary discharge

    Science.gov (United States)

    Frolov, Oleksandr; Kolacek, Karel; Schmidt, Jiri; Straus, Jaroslav

    2014-08-01

    In the last decade EUV sources attract interest from researchers over the world. One of the main motivations is EUV lithography, which could lead to further miniaturization in electronics. Nitrogen recombination laser at wavelength of 13.4 nm based on capillary discharge Z-pinch configuration could be used in experiments with testing of resolution of photoresist for EUV lithography (close to wavelength of 13.5 nm Si/Mo multilayer mirrors have a high reflectivity at normal incidence angles). In this work, pinching of nitrogen-filled capillary discharge is studied for the development of EUV laser, which is based on recombination pumping scheme. The goal of this study is achieving the required plasma conditions using a capillary discharge Z-pinch apparatus. In experiments with nitrogen, the capillary length was shortened from 232 mm to 90 mm and current quarter-period was changed from 60 ns to 50 ns in contrast with early experiments with Ne-like argon laser. EUV radiation from capillary discharge was registered by X-ray vacuum diode for different pressure, amplitude and duration of pre-pulse and charging voltage of the Marx generator.

  20. CSNI specialist meeting on leak-before-break in nuclear reactor piping: proceedings

    International Nuclear Information System (INIS)

    On September 1 and 2, 1983, the CSNI subcommittee on primary system integrity held a special meeting in Monterey, California, on the subject of leak-before-break in nuclear reactor piping systems. The purpose of the meeting was to provide an international forum for the exchange of ideas, positions, and research results; to identify areas requiring additional research and development; and to determine the general attitude toward acceptance of the leak-before-break concept. The importance of the leak-before-break issue was evidenced by excellent attendance at the meeting and through active participation by the meeting attendees. Approximately 125 people representing fifteen different nations attended the meeting. The meeting was divided into four technical sessions addressing the following areas: Application of Piping Fracture Mechanics to Leak-Before Break, Leak Rate and Leak Detection, Leak-Before-Break Studies, Methods and Results, Current and Proposed Positions on Leak-Before-Break

  1. 75 FR 4134 - Pipeline Safety: Leak Detection on Hazardous Liquid Pipelines

    Science.gov (United States)

    2010-01-26

    ... leak detection process. Currently, there are 421 hazardous liquid pipeline operators. Two hundred and... required to comply with API RP 1130. Pipeline operators who do not employ computerized leak detection...

  2. Leak detection and localization system through acoustics; Sistema de deteccao e localizacao de vazamentos por acustica

    Energy Technology Data Exchange (ETDEWEB)

    Alonso, Julio [Aselco Automacao, Sao Paulo, SP (Brazil)

    2003-07-01

    Acoustic Leak Detection Systems (ALDS) are used on both liquid and gas pipelines as well as multi-phase flow pipelines to detect leaks quickly and provide a means of limiting product loss. The real-time acoustic signal is continuously compared against signature leak profiles for the particular operating and geometric conditions. These profiles were developed from a database established from over 20 years of experimental and field leak tests. This technique not only drastically reduces the false alarm rate, but also significantly improves the sensitivity and leak location accuracy. This system will also detect leaks with shut-in flow (zero flow rate in the pipeline). With the use of GPS (Global Positioning System) it not only improves leak location accuracy, but also allows for continuous leak detection during the loss of communications. (author)

  3. Leaks in nuclear grade high efficiency aerosol filters

    Energy Technology Data Exchange (ETDEWEB)

    Scripsick, R.C.

    1994-07-01

    Nuclear grade high efficiency aerosol filters, also known as high efficiency particulate air (HEPA) filters, are commonly used in air cleaning systems for removal of hazardous aerosols. Performance of the filter units is important in assuring health and environmental protection. The filter units are constructed from pleated packs of fiberglass filter media sealed into rigid frames. Results of previous studies on such filter units indicate that their performance may not be completely predicted by ideal performance of the fibrous filter media. In this study, departure from ideal performance is linked to leaks existing in filter units and overall filter unit performance is derived from independent performance of the individual filter unit components. The performance of 14 nuclear grade HEPA filter units (size 1, 25 cfm) with plywood frames was evaluated with a test system that permitted independent determination of penetration as a function of particle size for the whole filter unit, the filter unit frame, and the filter media pack. Tests were performed using a polydisperse aerosol of di-2-ethylhexyl phthalate with a count median diameter of 0.2 {mu}m and geometric standard deviation of 1.6. Flow rate and differential pressure were controlled from 1% to 100% of design values. Particle counts were made upstream and downstream of the filter unit with an optical particle counter (OPC). The OPC provided count information in 28 size channels over the particle diameter range from 0.1 to 0.7 {mu}m. Results provide evidence for a two component leak model of filler unit performance with: (1) external leaks through filter unit frames, and (2) internal leaks through defects in the media and through the seal between the media pack and frame. For the filter units evaluated, these leaks dominate overall filter unit performance over much of the flow rate and particle size ranges tested.

  4. Joubert Syndrome

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Joubert Syndrome Information Page Table of Contents (click to ... Organizations Related NINDS Publications and Information What is Joubert Syndrome? Joubert syndrome is a rare brain malformation ...

  5. Marfan Syndrome

    Science.gov (United States)

    Marfan syndrome is a disorder that affects connective tissue. Connective tissues are proteins that support skin, bones, ... fibrillin. A problem with the fibrillin gene causes Marfan syndrome. Marfan syndrome can be mild to severe, ...

  6. Novel absorption detection techniques for capillary electrophoresis

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Y.

    1994-07-27

    Capillary electrophoresis (CE) has emerged as one of the most versatile separation methods. However, efficient separation is not sufficient unless coupled to adequate detection. The narrow inner diameter (I.D.) of the capillary column raises a big challenge to detection methods. For UV-vis absorption detection, the concentration sensitivity is only at the {mu}M level. Most commercial CE instruments are equipped with incoherent UV-vis lamps. Low-brightness, instability and inefficient coupling of the light source with the capillary limit the further improvement of UV-vis absorption detection in CE. The goals of this research have been to show the utility of laser-based absorption detection. The approaches involve: on-column double-beam laser absorption detection and its application to the detection of small ions and proteins, and absorption detection with the bubble-shaped flow cell.

  7. Capillary filling in closed end nanochannels.

    Science.gov (United States)

    Phan, Vinh Nguyen; Nguyen, Nam-Trung; Yang, Chun; Joseph, Pierre; Djeghlaf, Lyes; Bourrier, David; Gue, Anne-Marie

    2010-08-17

    We investigated the interactions between liquid, gas, and solid phases in the capillary filling process of closed-end nanochannels. This paper presents theoretical models without and with absorption and diffusion of gas molecules in the liquid. Capillary filling experiments were carried out in closed-end silicon nanochannels with different lengths. The theoretical and measured characteristics of filling length versus time are compared. The results show that the filling process consists of two stages. The first stage resembles the capillary filling process in an open-end nanochannel. However, a remarkable discrepancy between the experimental results and the theory without gas absorption is observed in the second stage. A closer investigation of the second stage reveals that the dissolution of gas in the liquid is important and can be explained by the model with gas absorption and diffusion. PMID:20695566

  8. Capillary interactions in nano-particle suspensions

    International Nuclear Information System (INIS)

    We have investigated the structures formed by colloidal particles suspended in solvents at volume fractions below 10% and interacting through capillary bridges. Such systems resemble colloidal gas of sticky nano-spheres that form pearl-necklace like chains that, in turn, induce strong viscoelasticity due to the formation of 3-D fractal network. The capillary force dominates the electrostatic and Van der Waals forces in solutions and can bridge multiple particles depending of the volume of the capillary bridge. We have investigated the morphology of the structures formed at different fractions of the bridging fluid. Small-angle neutron scattering (SANS) is used to study nanoparticles with an average diameter of 10 nm in polar and non-polar organic solvents at ambient temperatures. SANS intensity as a function of the scattering vector is analyzed as a product of a form factor, that depends on the particle shape, and a structure factor, that characterizes the interparticle inter reactions. The interaction of particles in polar solvents is considered to be through electrostatic repulsion and the data is successfully fitted by Hayter-Penfold mean spherical approximation (HPMSA). Computer simulations of a pearl necklace-like chain of spheres is conducted to explain the structure factor when capillary bridges are present. Alternatively, we have analyzed the slope of the intensity at low scattering vector in a double logarithmic plot to determine the dimension of the fractal structures formed by the particles at different volume fraction of the bridging fluid. We have also studied the properties of the capillary bridge between a pair of particles. The significance of this study is to explore the possibility of using capillary force as a tool to engineer new colloidal structures and materials in solutions and to optimize their viscoelastic properties. (author)

  9. An automatic monitoring system of leak current for testing TGC detectors based on LabVIEW

    International Nuclear Information System (INIS)

    An automatic monitoring system of leak current for testing TGC detectors with high voltage was set up by using the graphic LabVIEW platform and NI 4351 data acquisition card. The leak current was automatically monitored and recorded with this system, the time and the value of the leak current were showed instantly. Good efficiency and precision of monitoring were obtained. (authors)

  10. Hanford Double-Shell Tank AY-102 Radioactive Waste Leak Investigation Update

    Energy Technology Data Exchange (ETDEWEB)

    Washenfelder, Dennis J. [Washington River Protection Solutions, Richland, WA (United States)

    2015-02-03

    The presentation outline is: Briefly review leak integrity status of tank AY-102 and current leak behavior; Summarize recent initiatives to understand leak mechanism and to verify integrity of remaining waste confinement structures; describe planned waste recovery activities; and, introduce other papers on tank AY-102 topics.

  11. 40 CFR 65.146 - Nonflare control devices used for equipment leaks only.

    Science.gov (United States)

    2010-07-01

    ... equipment leaks only. 65.146 Section 65.146 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Routing to a Fuel Gas System or a Process § 65.146 Nonflare control devices used for equipment leaks only... nonflare control device used only to control emissions from equipment leaks. (c) Monitoring...

  12. Hanford Single-Shell Tank Leak Causes and Locations - 241-B Farm

    Energy Technology Data Exchange (ETDEWEB)

    Girardot, Crystal L. [Washington River Protection Systems, Richland, WA (United States); Harlow, Donald G. [Washington River Protection Systems, Richland, WA (United States)

    2013-07-11

    This document identifies 241-B Tank Farm (B Farm) leak cause and locations for the 100 series leaking tank (241-B-107) identified in RPP-RPT-49089, Hanford B-Farm Leak Inventory Assessments Report. This document satisfies the B Farm portion of the target (T04) in the Hanford Federal Facility Agreement and Consent Order milestone M-045-91F.

  13. 40 CFR 63.502 - Equipment leak and heat exchange system provisions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Equipment leak and heat exchange system... Equipment leak and heat exchange system provisions. (a) Equipment leak provisions. The owner or operator of... this part specify that Method 18, 40 CFR part 60, appendix A shall be used, either Method 18 or...

  14. Capillary Rise of Liquids in Nanopores

    CERN Document Server

    Huber, Patrick; Kityk, Andriy V

    2006-01-01

    We present measurements on the spontaneous imbibition (capillary rise) of water, a linear hydrocarbon (n-C16H34) and a liquid crystal (8OCB) into the pore space of monolithic, nanoporous Vycor glass (mean pore radius 5 nm). Measurements on the mass uptake of the porous hosts as a function of time, m(t), are in good agreement with the Lucas-Washburn square root of time prediction, typical of imbibition of liquids into porous hosts. The relative capillary rise velocities scale as expected from the bulk fluid parameters.

  15. A lymph nodal capillary-cavernous hemangioma.

    Science.gov (United States)

    Dellachà, A; Fulcheri, E; Campisi, C

    1999-09-01

    A capillary-cavernous hemangioma in an obturator lymph node was found incidentally in a 64 year-old woman who had undergone unilateral salpingo-oophorectomy and lymphadenectomy for an ovarian neoplasm. Vascular tumors of lymph nodes are briefly reviewed including eight previously described nodal capillary-cavernous hemangiomas. The association with other splanchnic hemangiomas is pointed out and the likelihood that the lesion is a hamartoma rather than a true neoplasm is addressed. Despite its rarity, this entity needs to be recognized by lymphologists who image lymph nodes by lymphangiography as well as by lymph nodal pathologists. PMID:10494525

  16. Intracerebral Capillary Hemangioma: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Youn, In Young; Kim, Jae Kyun; Byun, Jun Soo [Dept. of Radiology, Chung Ang University Medical Center, Chung Ang University College of Medicine, Seoul (Korea, Republic of); Park, Eon Sub [Dept. of Radiology, Chung Ang University Medical Center, Chung Ang University College of Medicine, Seoul (Korea, Republic of)

    2012-01-15

    Intracerebral capillary hemangiomas are very rare benign vascular tumors that mostly occur during infancy. We described a 69-year-old man with generalized tonic-clonic seizures who was diagnosed with an intracranial mass. Multidetector computed tomography, magnetic resonance imaging and digital subtraction angiography studies were performed for evaluation of brain, and there was a well-enhancing mass found in the right temporal lobe without a definite feeding vessel. The patient underwent surgery and the pathologic examination demonstrated marked proliferation of small vessels with a lobular pattern in the brain parenchyma, which was confirmed to be capillary hemangioma.

  17. Microfluidic chip-capillary electrophoresis devices

    CERN Document Server

    Fung, Ying Sing; Du, Fuying; Guo, Wenpeng; Ma, Tongmei; Nie, Zhou; Sun, Hui; Wu, Ruige; Zhao, Wenfeng

    2015-01-01

    Capillary electrophoresis (CE) and microfluidic chip (MC) devices are relatively mature technologies, but this book demonstrates how they can be integrated into a single, revolutionary device that can provide on-site analysis of samples when laboratory services are unavailable. By introducing the combination of CE and MC technology, Microfluidic Chip-Capillary Electrophoresis Devices broadens the scope of chemical analysis, particularly in the biomedical, food, and environmental sciences.The book gives an overview of the development of MC and CE technology as well as technology that now allows

  18. TESTICULAR CAPILLARY HEMANGIOMA: DESCRIPTION OF A CASE

    Directory of Open Access Journals (Sweden)

    A. S. Markova

    2014-07-01

    Full Text Available The paper describes a clinical case of testicular capillary hemangioma in a 24-year-old man undergone a partial resection of the testis with the intraoperative morphological examination. Testicular capillary hemangioma is a rare benign tumor of a vascular origin, which can be similar to malignant testicular tumors on the clinical presentation, as well as on the imaging methods, in particular to seminoma. The intraoperative histological study can assist in avoiding organ-removing surgical interventions in diagnostically ambiguous cases if a benign testicular tumor is diagnosed.

  19. Symptomatic hemorrhagic pleural effusion: A rare presentation of ovarian hyperstimulation syndrome: A Case Report

    OpenAIRE

    Alaraj, Ali

    2013-01-01

    Isolated unilateral pleural effusion is uncommon presentation of ovarian hyperstimulation syndrome. The pathogenesis of this syndrome involves an increased permeability of ovarian capillaries and mesothelial vessels triggered by the release of vasoactive substances by the ovaries under human chorionic gonadotropin stimulation. Physicians should consider this potentially life-threatening diagnosis in all patients who undergo ovarian hyperstimulation. This case highlights a rare clinical manife...

  20. The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs

    OpenAIRE

    João José Pereira da Silva; Bernardino Alves de Souza Netto; Walter Lilembaum; Maria Erbene Amorim Melo Alvim; Albanita Viana de Oliveira

    1995-01-01

    The hemorrhagic syndrome of leptospirosis was studied in guinea pigs. The study correlates hematological, histopathological and immunohistochemical alterations in sixty animals inoculated by the intraperitoneal route with lml of the culture of virulent strain of Leptospira interrogans serovar copenhageni. Leptospirae antigens were detected by immunoperoxidase, chiefly in liver, kidney and heart muscle capillaries. Possible pathogenic mechanisms responsible for hemorrhagic syndrome are discuss...

  1. Quantification of nucleotides by ICPMS: coupling of ICPMS with capillary electrophoresis or capillary HPLC

    International Nuclear Information System (INIS)

    Full text: Quantification of nucleotides in small volumes of biological samples has eagerly been demanded. A method using ICPMS coupled with capillary electrophoresis or capillary liquid chromatography is reported. A new interface system, which consists of a double tube nebulizer inserted with a fused silica capillary tube and a cylinder mini-chamber with a sheath gas inlet, was designed. Moreover, the surface conditions of the sampling and skimmer cones, and the introduction of H2 gas into the plasma were found to significantly improve the signal/background ratio for phosphorus determination at m/z 31. (author)

  2. Viscosity measurement in the capillary tube viscometer under unsteady flow

    International Nuclear Information System (INIS)

    The objective of the present study is to develop a new device that the viscous characteristics of fluids are determined by applying the unsteady flow concept to the traditional capillary tube viscometer. The capillary tube viscometer consists of a small cylindrical reservoir, capillary tube, a load cell system that measures the mass flow rate, interfaces, and computer. Due to the small size of the reservoir the height of liquid in the reservoir decreases as soon as the liquid in the reservoir drains out through the capillary and the mass flow rate in the capillary decreases as the hydrostatic pressure in the reservoir decreases resulting in a decrease of the shear rate in the capillary tube. The instantaneous shear rate and driving force in the capillary tube are determined by measuring the mass flow rate through the capillary, and the fluid viscosity is determined from the measured flow rate and the driving force

  3. A Rare Association of Trigeminal Autonomic Cephalgia: Pontine Capillary Telangiectasia

    OpenAIRE

    Gocmen, Rahsan; Kurt, Erdal; Arslan, Sabina; Unal-Cevik, Isin; Karli Oguz, Kader; Tezer, F Irsel

    2015-01-01

    This report describes a case of pontine capillary telangiectasia in a 43-year-old woman with a clinical diagnosis of trigeminal autonomic cephalgia. The possible association with pontine capillary telangiectasia and trigeminal autonomic cephalgia is discussed.

  4. Tank S-102 waste retrieval leak detection and monitoring and mitigation strategy

    International Nuclear Information System (INIS)

    This paper presents a proactive and mitigative strategy for the identification and management of potential S-102 waste leaks during the S-102 Waste Retrieval and the basis for this approach. The strategy is based on preventing leakage, minimizing leak volumes if a lead should occur, and providing the best available leak detection and monitoring technologies. Ex-tank leak detection will use the baseline borehole gamma and neutron drywell logging trucks, supplemented with manually deployed neutron moisture measurements. Waste mitigation includes management of the retrieval fluids in a manner that limits the risk for a potential leak

  5. Study of Internal and External Leaks in Tests of Anode-Supported SOFCs

    DEFF Research Database (Denmark)

    Rasmussen, Jens Foldager Bregnballe; Hendriksen, Peter Vang; Hagen, Anke

    2008-01-01

    Spectrometer were used to detect both internal (through electrolyte) and external (through seals) gas leaks. The internal gas leak through the electrolyte was quantified under different conditions, as was the external leak from the surroundings to the anode. The internal gas leak did not depend on the pressure...... difference between the anode and the cathode gas compartment, and can thus be described as diffusion driven. External leaks between the surroundings and the anode, but not the cathode gas compartment was observed. They were influenced by the pressure difference and are thus driven by both concentration and...

  6. MCO combustible gas management leak test acceptance criteria

    International Nuclear Information System (INIS)

    Existing leak test acceptance criteria for mechanically sealed and weld sealed multi-canister overpacks (MCO) were evaluated to ensure that MCOs can be handled and stored in stagnant air without compromising the Spent Nuclear Fuel Project's overall strategy to prevent accumulation of combustible gas mixtures within MCO's or within their surroundings. The document concludes that the integrated leak test acceptance criteria for mechanically sealed and weld sealed MCOs (1 x 10-5 std cc/sec and 1 x 10-7 std cc/sec, respectively) are adequate to meet all current and foreseeable needs of the project, including capability to demonstrate compliance with the NFPA 60 Paragraph 3-3 requirement to maintain hydrogen concentrations [within the air atmosphere CSB tubes] t or below 1 vol% (i.e., at or below 25% of the LFL)

  7. Massive Cerebrospinal Fluid Leak of the Temporal Bone

    Directory of Open Access Journals (Sweden)

    Giannicola Iannella

    2016-01-01

    Full Text Available Cerebrospinal fluid (CSF leakage of the temporal bone region is defined as abnormal communications between the subarachnoidal space and the air-containing spaces of the temporal bone. CSF leak remains one of the most frequent complications after VS surgery. Radiotherapy is considered a predisposing factor for development of temporal bone CSF leak because it may impair dural repair mechanisms, thus causing inadequate dural sealing. The authors describe the case of a 47-year-old man with a massive effusion of CSF which extended from the posterior and lateral skull base to the first cervical vertebrae; this complication appeared after a partial enucleation of a vestibular schwannoma (VS with subsequent radiation treatment and second operation with total VS resection.

  8. Sodium leak at Monju (I): Cause and consequences

    International Nuclear Information System (INIS)

    On December 8, 1995, a sodium leak from the Secondary Heat Transport System (SHTS) occurred in a piping room of the reactor auxiliary building at Monju. The sodium leaked through a thermocouple temperature sensor due to the breakage of the well tube of the sensor installed near the outlet of the Intermediate Heat Exchanger (IHX) in SHTS Loop C. There were no adverse effects for operating personnel or the surrounding environment. The reactor core remained cooled and thus, from the viewpoint of radiological hazards, the safety of the reactor was secured. On the basis of the investigations, it was concluded that the breakage of the thermocouple well was caused by high cycle fatigue due to flow induced vibration in the direction of sodium flow. (author)

  9. Integrated leak rate test (ILRT) of Indian PHWR

    International Nuclear Information System (INIS)

    Full text: This paper summarizes the various requirements and activities relevant to the ILRT of the Indian pressurized heavy water reactors (PHWR) containment system in particular standardized 220 MWe plants of RAPS/ Kaiga. All Indian PHWR containment are constructed from concrete either reinforced or prestressed or a combination of both and lined with polymeric coating based on epoxy or vinyl in order to achieve the leak tightness necessary from the radiological considerations following an accident. The ILRT conducted on the containment prior to the first operation include testing of the various envelopes and barriers. The various tests include: leakage rate testing of the various penetration and isolation devices. Integrated leakage rate test of the containments. Test to confirm the interception of primary containment leak by secondary containment

  10. Locating leaking fuel rods in light water reactors

    International Nuclear Information System (INIS)

    Several techniques have been developed to perform the rod-by-rod leakage discrimination tests on nuclear fuel elements that rod replacement requires, including visual, vibrational analysis, eddy current and ultrasonic techniques. The ultrasonic technique has proved to have the most potential. It is the only system that in the field has provided a reliable, unambiguous indication of which fuel pins have leaked and which are intact without moving any fuel rods in the assembly. The through-transmission system is shown to be reliable and has been successfully used in many countries. It depends however, on specialised personnel to operate it and interpret the data. A new system, Echo-330, has been developed by Babcock and Wilcox. This is fully automated, and uses a multiple probe system with computerized control and data evaluation. The probe design is illustrated and typical output data shown. The time needed to locate leaking fuel rods is considerably reduced. (U.K.)

  11. Iatrogenic cerebrospinal fluid leak and intracranial hypotension after gynecological surgery.

    Science.gov (United States)

    Tu, Albert; Creedon, Kerry; Sahjpaul, Ramesh

    2014-09-01

    Perineural cysts are common lesions of the sacral spine. They have rarely been reported in a presacral location, leading to their misdiagnosis as a gynecological lesion. The authors report the second such case, in a patient undergoing fenestration of what was presumed to be a benign pelvic cyst, and the resultant high-flow CSF leak that occurred. They describe the clinical presentation and manifestations of intracranial hypotension, as well as the pertinent investigations. They also review the literature for the best management options for this condition. Although they are uncommon, large perineural cysts should be included in the differential diagnosis when examining patients with a pelvic lesion. Appropriate imaging investigations should be performed to rule out a perineural cyst. The CSF leak that occurs from iatrogenic cyst fenestration may not respond to traditional first-line treatments for intracranial hypotension and may require early surgical intervention. The authors would recommend neurosurgical involvement prior to definitive treatment. PMID:24905389

  12. Method for HEPA filter leak scanning with differentiating aerosol detector

    Energy Technology Data Exchange (ETDEWEB)

    Kovach, B.J.; Banks, E.M.; Wikoff, W.O. [NUCON International, Inc., Columbus, OH (United States)

    1997-08-01

    While scanning HEPA filters for leaks with {open_quotes}Off the Shelf{close_quote} aerosol detection equipment, the operator`s scanning speed is limited by the time constant and threshold sensitivity of the detector. This is based on detection of the aerosol density, where the maximum signal is achieved when the scanning probe resides over the pinhole longer than several detector time-constants. Since the differential value of the changing signal can be determined by observing only the first small fraction of the rising signal, using a differentiating amplifier will speed up the locating process. The other advantage of differentiation is that slow signal drift or zero offset will not interfere with the process of locating the leak, since they are not detected. A scanning hand-probe attachable to any NUCON{reg_sign} Aerosol Detector displaying the combination of both aerosol density and differentiated signal was designed. 3 refs., 1 fig.

  13. Troponin leak associated with drug-induced methemoglobinemia.

    Science.gov (United States)

    Cannon, Robert D; Wagner, Michael; Jacoby, Jeanne L

    2014-10-01

    Drug-induced methemoglobinemia is a well-described entity but has not been previously associated with elevated troponins in the absence of cardiac symptoms. We report a case of a patient presenting to the emergency department (ED) with complaints related to an exacerbation of her long-standing cystitis. A low pulse oximetry reading prompted an evaluation, revealing a troponin leak, which peaked at 10 hours. Her methemoglobin level was found to be elevated at 11.4%, but a preexisting anemia apparently prevented the clinical recognition of cyanosis. The methemoglobinemia was determined to be secondary to her ingestion of phenazopyridine and trimethoprim-sulfa methoxizole. Although phenazopyridine and sulfa agents have long been known to cause methemoglobinemia, our patient exhibited an asymptomatic troponin leak that has not been previously reported as a complication of drug-induced methemoglobinemia. Clinicians should be aware of this potential association. PMID:24686024

  14. Method for HEPA filter leak scanning with differentiating aerosol detector

    International Nuclear Information System (INIS)

    While scanning HEPA filters for leaks with open-quotes Off the Shelf close-quote aerosol detection equipment, the operator's scanning speed is limited by the time constant and threshold sensitivity of the detector. This is based on detection of the aerosol density, where the maximum signal is achieved when the scanning probe resides over the pinhole longer than several detector time-constants. Since the differential value of the changing signal can be determined by observing only the first small fraction of the rising signal, using a differentiating amplifier will speed up the locating process. The other advantage of differentiation is that slow signal drift or zero offset will not interfere with the process of locating the leak, since they are not detected. A scanning hand-probe attachable to any NUCON reg-sign Aerosol Detector displaying the combination of both aerosol density and differentiated signal was designed. 3 refs., 1 fig

  15. Application of CHESS single-bounce capillaries at synchrotron beamlines

    Science.gov (United States)

    Huang, R.; Szebenyi, T.; Pfeifer, M.; Woll, A.; Smilgies, D.-M.; Finkelstein, K.; Dale, D.; Wang, Y.; Vila-Comamala, J.; Gillilan, R.; Cook, M.; Bilderback, D. H.

    2014-03-01

    Single-bounce capillaries are achromatic X-ray focusing optics that can provide efficient and high demagnification focusing with large numerical apertures. Capillary fabrication at CHESS can be customized according to specific application requirements. Exemplary applications are reviewed in this paper, as well as recent progress on condensers for high-resolution transmission X-ray microscopy and small focal size capillaries.

  16. High-resolution wide-field imaging of perfused capillaries without the use of contrast agent

    Directory of Open Access Journals (Sweden)

    Nelson DA

    2011-08-01

    Full Text Available Darin A Nelson1, Zvia Burgansky-Eliash1,2, Hila Barash1, Anat Loewenstein3, Adiel Barak4, Elisha Bartov2, Tali Rock2, Amiram Grinvald51Optical Imaging Ltd, Rehovot, Israel; 2Department of Ophthalmology, Edith Wolfson Medical Center, Holon, Israel; 3Department of Ophthalmology, Tel Aviv Medical Center & Sackler Faculty of Medicine, Tel Aviv University, Israel; 4Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 5Department of Neurobiology, The Weizmann Institute of Science, Rehovot, IsraelPurpose: Assessment of capillary abnormalities facilitates early diagnosis, treatment, and follow-up of common retinal pathologies. Injected contrast agents like fluorescein are widely used to image retinal capillaries, but this highly effective procedure has a few disadvantages, such as untoward side effects, inconvenience of injection, and brevity of the time window for clear visualization. The retinal function imager (RFI is a tool for monitoring retinal functions, such as blood velocity and oximetry, based on intrinsic signals. Here we describe the clinical use of hemoglobin in red blood cells (RBCs as an intrinsic motion-contrast agent in the generation of detailed noninvasive capillary-perfusion maps (nCPMs.Patients and methods: Multiple series of nCPM images were acquired from 130 patients with diabetic retinopathy, vein occlusion, central serous retinopathy, age-related macular degeneration, or metabolic syndrome, as well as from 37 healthy subjects. After registration, pixel value distribution parameters were analyzed to locate RBC motion.Results: The RFI yielded nCPMs demonstrating microvascular morphology including capillaries in exquisite detail. Maps from the same subject were highly reproducible in repeated measurements, in as much detail and often better than that revealed by the very best fluorescein angiography. In patients, neovascularization and capillary nonperfusion areas were clearly observed. Foveal avascular

  17. Numerical simulations of capillary barrier field tests

    Energy Technology Data Exchange (ETDEWEB)

    Morris, C.E. [Univ. of Wollongong (Australia); Stormont, J.C. [Univ. of New Mexico, Albuquerque, NM (United States)

    1997-12-31

    Numerical simulations of two capillary barrier systems tested in the field were conducted to determine if an unsaturated flow model could accurately represent the observed results. The field data was collected from two 7-m long, 1.2-m thick capillary barriers built on a 10% grade that were being tested to investigate their ability to laterally divert water downslope. One system had a homogeneous fine layer, while the fine soil of the second barrier was layered to increase its ability to laterally divert infiltrating moisture. The barriers were subjected first to constant infiltration while minimizing evaporative losses and then were exposed to ambient conditions. The continuous infiltration period of the field tests for the two barrier systems was modelled to determine the ability of an existing code to accurately represent capillary barrier behavior embodied in these two designs. Differences between the field test and the model data were found, but in general the simulations appeared to adequately reproduce the response of the test systems. Accounting for moisture retention hysteresis in the layered system will potentially lead to more accurate modelling results and is likely to be important when developing reasonable predictions of capillary barrier behavior.

  18. Modeling of Throttling Process inside Capillary Tube

    Czech Academy of Sciences Publication Activity Database

    Vinš, Václav; Vacek, V.

    Praha : ČVUT, 2009, s. 250-251. ISBN 978-80-01-04286-1. [ANNUAL CTU UNIVERSITY-WIDE SEMINAR /18./. Praha (CZ), 16.02.2009-20.02.2009] Institutional research plan: CEZ:AV0Z20760514 Keywords : capillary tube * numerical model * metastable flow Subject RIV: BJ - Thermodynamics https://workshop.cvut.cz/2009/

  19. Planetary In Situ Capillary Electrophoresis System (PISCES)

    Science.gov (United States)

    Willis, P. A.; Stockton, A. M.; Mora, M. F.; Cable, M. L.; Bramall, N. E.; Jensen, E. C.; Jiao, H.; Lynch, E.; Mathies, R. A.

    2012-10-01

    We propose to develop PISCES, a 3-kg, 2W, flight-capable microfluidic lab-on-a-chip capillary electrophoresis analyzer capable of ingesting solid, liquid, or gas samples and performing a suite of chemical analyses with parts per trillion sensitivity.

  20. Imbibition of ``Open Capillary'': Fundamentals and Applications

    Science.gov (United States)

    Tani, Marie; Kawano, Ryuji; Kamiya, Koki; Okumura, Ko

    2015-11-01

    Control or transportation of small amount of liquid is one of the most important issues in various contexts including medical sciences or pharmaceutical industries to fuel delivery. We studied imbibition of ``open capillary'' both experimentally and theoretically, and found simple scaling laws for both statics and dynamics of the imbibition, similarly as that of imbibition of capillary tubes. Furthermore, we revealed the existence of ``precursor film,'' which developed ahead of the imbibing front, and the dynamics of it is described well by another scaling law for capillary rise in a corner. Then, to show capabilities of open capillaries, we demonstrated two experiments by fabricating micro mixing devices to achieve (1) simultaneous multi-color change of the Bromothymol blue (BTB) solution and (2) expression of the green florescent protein (GFP). This research was partly supported by ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan). M. T. is supported by the Japan Society for the Promotion of Science Research Fellowships for Young Scientists.

  1. Analytical biotechnology: Capillary electrophoresis and chromatography

    International Nuclear Information System (INIS)

    The papers describe the separation, characterization, and equipment required for the electrophoresis or chromatography of cyclic nucleotides, pharmaceuticals, therapeutic proteins, recombinant DNA products, pheromones, peptides, and other biological materials. One paper, On-column radioisotope detection for capillary electrophoresis, has been indexed separately for inclusion on the data base

  2. Macroscopic theory for capillary-pressure hysteresis.

    Science.gov (United States)

    Athukorallage, Bhagya; Aulisa, Eugenio; Iyer, Ram; Zhang, Larry

    2015-03-01

    In this article, we present a theory of macroscopic contact angle hysteresis by considering the minimization of the Helmholtz free energy of a solid-liquid-gas system over a convex set, subject to a constant volume constraint. The liquid and solid surfaces in contact are assumed to adhere weakly to each other, causing the interfacial energy to be set-valued. A simple calculus of variations argument for the minimization of the Helmholtz energy leads to the Young-Laplace equation for the drop surface in contact with the gas and a variational inequality that yields contact angle hysteresis for advancing/receding flow. We also show that the Young-Laplace equation with a Dirichlet boundary condition together with the variational inequality yields a basic hysteresis operator that describes the relationship between capillary pressure and volume. We validate the theory using results from the experiment for a sessile macroscopic drop. Although the capillary effect is a complex phenomenon even for a droplet as various points along the contact line might be pinned, the capillary pressure and volume of the drop are scalar variables that encapsulate the global quasistatic energy information for the entire droplet. Studying the capillary pressure versus volume relationship greatly simplifies the understanding and modeling of the phenomenon just as scalar magnetic hysteresis graphs greatly aided the modeling of devices with magnetic materials. PMID:25646688

  3. Numerical simulations of capillary barrier field tests

    International Nuclear Information System (INIS)

    Numerical simulations of two capillary barrier systems tested in the field were conducted to determine if an unsaturated flow model could accurately represent the observed results. The field data was collected from two 7-m long, 1.2-m thick capillary barriers built on a 10% grade that were being tested to investigate their ability to laterally divert water downslope. One system had a homogeneous fine layer, while the fine soil of the second barrier was layered to increase its ability to laterally divert infiltrating moisture. The barriers were subjected first to constant infiltration while minimizing evaporative losses and then were exposed to ambient conditions. The continuous infiltration period of the field tests for the two barrier systems was modelled to determine the ability of an existing code to accurately represent capillary barrier behavior embodied in these two designs. Differences between the field test and the model data were found, but in general the simulations appeared to adequately reproduce the response of the test systems. Accounting for moisture retention hysteresis in the layered system will potentially lead to more accurate modelling results and is likely to be important when developing reasonable predictions of capillary barrier behavior

  4. Fully covered self-expandable metal stents (SEMS, partially covered SEMS and self-expandable plastic stents for the treatment of benign esophageal ruptures and anastomotic leaks

    Directory of Open Access Journals (Sweden)

    van Boeckel Petra GA

    2012-02-01

    Full Text Available Abstract Background Benign esophageal ruptures and anastomotic leaks are life-threatening conditions that are often treated surgically. Recently, placement of partially and fully covered metal or plastic stents has emerged as a minimally invasive treatment option. We aimed to determine the clinical effectiveness of covered stent placement for the treatment of esophageal ruptures and anastomotic leaks with special emphasis on different stent designs. Methods Consecutive patients who underwent placement of a fully covered self-expandable metal stent (FSEMS, a partially covered SEMS (PSEMS or a self-expanding plastic stent (SEPS for a benign esophageal rupture or anastomotic leak after upper gastrointestinal surgery in the period 2007-2010 were included. Data on patient demographics, type of lesion, stent placement and removal, clinical success and complications were collected Results A total of 52 patients received 83 esophageal stents (61 PSEMS, 15 FSEMS, 7 SEPS for an anastomotic leak (n = 32, iatrogenic rupture (n = 13, Boerhaave's syndrome (n = 4 or other cause (n = 3. Endoscopic stent removal was successful in all but eight patients treated with a PSEMS due to tissue ingrowth. Clinical success was achieved in 34 (76%, intention-to-treat: 65% patients (PSEMS: 73%, FSEMS: 83%, SEPS: 83% after a median of 1 (range 1-5 stent and a median stenting time of 39 (range 7-120 days. In total, 33 complications in 24 (46% patients occurred (tissue in- or overgrowth (n = 8, stent migration (n = 10, ruptured stent cover (all Ultraflex; n = 6, food obstruction (n = 3, severe pain (n = 2, esophageal rupture (n = 2, hemorrhage (n = 2. One (2% patient died of a stent-related cause. Conclusions Covered stents placed for a period of 5-6 weeks may well be an alternative to surgery for treating benign esophageal ruptures or anastomotic leaks. As efficacy between PSEMS, FSEMS and SEPS is not different, stent choice should depend on expected risks of stent migration

  5. Leak detection in pipelines through spectral analysis of pressure signals

    OpenAIRE

    Souza A.L.; Cruz S.L.; Pereira J.F.R.

    2000-01-01

    The development and test of a technique for leak detection in pipelines is presented. The technique is based on the spectral analysis of pressure signals measured in pipeline sections where the formation of stationary waves is favoured, allowing leakage detection during the start/stop of pumps. Experimental tests were performed in a 1250 m long pipeline for various operational conditions of the pipeline (liquid flow rate and leakage configuration). Pressure transients were obtained by four tr...

  6. The sodium-leak channel, NALCN, in health and disease

    OpenAIRE

    Maud eCochet-Bissuel; Philippe eLory; Arnaud eMonteil

    2014-01-01

    Ion channels are crucial components of cellular excitability and are involved in many neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors (GPCRs)-activated NALCN channel that is predominantly expressed in neurons where it regulates the resting membrane potential and neuronal excitability. NALCN is part of a complex that includes not only GPCRs, but also UNC-79, UNC-80, NLF-1 and src family of Tyrosine kinases (SFKs). There is growing evidence that the NA...

  7. The sodium leak channel, NALCN, in health and disease

    OpenAIRE

    Cochet-Bissuel, Maud; Lory, Philippe; Monteil, Arnaud

    2014-01-01

    Ion channels are crucial components of cellular excitability and are involved in many neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors (GPCRs)-activated NALCN channel that is predominantly expressed in neurons where it regulates the resting membrane potential and neuronal excitability. NALCN is part of a complex that includes not only GPCRs, but also UNC-79, UNC-80, NLF-1 and src family of Tyrosine kinases (SFKs). There is growing evidence that the NA...

  8. The leak before break criteria, requirements and implications

    International Nuclear Information System (INIS)

    Inside this work a general balance is made on the Leak before break approach (LBB), like they are the history and licensing, those limitations, the acceptance criteria of the LBB, the current state of the regulatory development and the current state of it application in countries like E.U.A, Germany, Canada, Italy and France. Everything it with the purpose of evaluating the opportunities that offers the LBB criteria for it possible application in Mexico. (Author)

  9. Leaks in the internal water supply piping systems

    Directory of Open Access Journals (Sweden)

    Orlov Evgeniy Vladimirovich

    2015-03-01

    Full Text Available Great water losses in the internal plumbing of a building lead to the waste of money for a fence, purification and supply of water volumes in excess. This does not support the concept of water conservation and resource saving lying today in the basis of any building’s construction having plumbing. Leakage means unplanned of water losses systems in domestic water supply systems (hot or cold as a result of impaired integrity, complicating the operation of a system and leading to high costs of repair and equipment restoration. A large number of leaks occur in old buildings, where the regulatory service life of pipelines has come to an end, and the scheduled repair for some reason has not been conducted. Steel pipelines are used in the systems without any protection from corrosion and they get out of order. Leakages in new houses are also not uncommon. They usually occur as a result of low-quality adjustment of the system by workers. It also important to note the absence of certain skills of plumbers, who don’t conduct the inspections of in-house systems in time. Sometimes also the residents themselves forget to keep their pipeline systems and water fittings in their apartment in good condition. Plumbers are not systematically invited for preventive examinations to detect possible leaks in the domestic plumbing. The amount of unproductive losses increases while simultaneous use of valve tenants, and at the increase of the number of residents in the building. Water leaks in the system depend on the amount of water system piping damages, and damages of other elements, for example, water valves, connections, etc. The pressure in the leak area also plays an important role.

  10. Numerical Simulation of Extended Leak-Off Tests

    OpenAIRE

    Eide, Vegard Veiteberg

    2014-01-01

    In-situ stresses are key information for well and formation integrity assessments, especially in difficult drilling operations such as high pressure high temperature wells, extended reach wells and in-fill drilling. During drilling, the minimum horizontal stress is best obtained by dedicated tests. In particular the extended leak-off test. Challenges associated with such tests are the quality of stress data obtained in complex stress regimes, difficult formations (plasticity, ductility, therm...

  11. Numerical modelling of concentrated leak erosion during Hole Erosion Tests

    OpenAIRE

    Mercier, F.; S. Bonelli; Golay, F.; Anselmet, F; Philippe, P.; Borghi, R.

    2015-01-01

    This study focuses on the numerical modelling of concentrated leak erosion of a cohesive soil by a turbulent flow in axisymmetrical geometry, with application to the Hole Erosion Test (HET). The numerical model is based on adaptive remeshing of the water/soil interface to ensure accurate description of the mechanical phenomena occurring near the soil/water interface. The erosion law governing the interface motion is based on two erosion parameters: the critical shear stress and the erosion co...

  12. 105-KE Isolation Barrier Leak Rate Acceptance Test Report

    Energy Technology Data Exchange (ETDEWEB)

    McCracken, K.J.

    1995-06-14

    This Acceptance Test Report (ATR) contains the completed and signed Acceptance Procedure (ATP) for the 105-KE Isolations Barrier Leak Rate Test. The Test Engineer`s log, the completed sections of the ATP in the Appendix for Repeat Testing (Appendix K), the approved WHC J-7s (Appendix H), the data logger files (Appendices T and U), and the post test calibration checks (Appendix V) are included.

  13. 105-KE Isolation Barrier Leak Rate Acceptance Test Report

    International Nuclear Information System (INIS)

    This Acceptance Test Report (ATR) contains the completed and signed Acceptance Procedure (ATP) for the 105-KE Isolations Barrier Leak Rate Test. The Test Engineer's log, the completed sections of the ATP in the Appendix for Repeat Testing (Appendix K), the approved WHC J-7s (Appendix H), the data logger files (Appendices T and U), and the post test calibration checks (Appendix V) are included

  14. 40 CFR 1065.644 - Vacuum-decay leak rate.

    Science.gov (United States)

    2010-07-01

    ... absolute temperature at time t2. p 1 = Vacuum-side absolute pressure at time t1. T 1 = Vacuum-side absolute temperature at time t1. t 2 = time at completion of vacuum-decay leak verification test. t 1 = time at start... criterion specified in § 1065.345(e). ER06MY08.028 Where: V vac = geometric volume of the vacuum-side of...

  15. Non-linear leak currents affect mammalian neuron physiology

    OpenAIRE

    Shiwei Huang; Sungho Hong

    2015-01-01

    In their seminal works on squid giant axons, Hodgkin, and Huxley approximated the membrane leak current as Ohmic, i.e., linear, since in their preparation, sub-threshold current rectification due to the influence of ionic concentration is negligible. Most studies on mammalian neurons have made the same, largely untested, assumption. Here we show that the membrane time constant and input resistance of mammalian neurons (when other major voltage-sensitive and ligand-gated ionic currents are dis...

  16. Leak detection, monitoring, and mitigation technology trade study update

    Energy Technology Data Exchange (ETDEWEB)

    HERTZEL, J.S.

    1998-11-10

    This document is a revision and update to the initial report that describes various leak detection, monitoring, and mitigation (LDMM) technologies that can be used to support the retrieval of waste from the single-shell tanks (SST) at the Hanford Site. This revision focuses on the improvements in the technical performance of previously identified and useful technologies, and it introduces new technologies that might prove to be useful.

  17. ACOUSTIC LOCATION OF LEAKS IN PRESSURIZED UNDER- GROUND PETROLEUM PIPELINES

    Science.gov (United States)

    Experiments were conducted at the Underground Storage Tank (UST) Test Apparatus Pipeline in which three acoustic sensors separated by a maximum distance of 38.1 m (125 ft) were used to monitor signals produced by 11.4-, 5.7-, and 3.8-L/h (3.0-, 1.5-, and 1.0-gal/h) leaks in th...

  18. Multiple-Feature Extracting Modules Based Leak Mining System Design

    Directory of Open Access Journals (Sweden)

    Ying-Chiang Cho

    2013-01-01

    mining system that is equipped with SQL injection vulnerability detection, by means of an algorithm developed for the web crawler. In addition, we analyze portal sites of the governments of various countries or regions in order to investigate the information leaking status of each site. Subsequently, we analyze the database structure and content of each site, using the data collected. Thus, we make use of practical verification in order to focus on information security and privacy through black-box testing.

  19. A Study of Potential Component Leaks in Android Apps

    OpenAIRE

    Li, Li; Allix, Kevin; Li, Daoyuan; Bartel, Alexandre; Bissyande, Tegawendé François D Assise; Klein, Jacques

    2015-01-01

    We discuss the capability of a new feature set for malware detection based on potential component leaks (PCLs). PCLs are defined as sensitive data-flows that involve Android inter-component communications. We show that PCLs are common in Android apps and that malicious applications indeed manipulate significantly more PCLs than benign apps. Then, we evaluate a machine learning-based approach relying on PCLs. Experimental validation show high performance with 95% precision for identifying malw...

  20. Leak detection, monitoring, and mitigation technology trade study update

    International Nuclear Information System (INIS)

    This document is a revision and update to the initial report that describes various leak detection, monitoring, and mitigation (LDMM) technologies that can be used to support the retrieval of waste from the single-shell tanks (SST) at the Hanford Site. This revision focuses on the improvements in the technical performance of previously identified and useful technologies, and it introduces new technologies that might prove to be useful

  1. Remote sensing of leaf responses to leaking underground natural gas

    OpenAIRE

    Smith, Karon Lesley

    2002-01-01

    Detection of leaking gas pipelines is important for safety, economic and environmental reasons. Remote sensing of vegetation offers the potential to identify gas leakage. The research aim was to determine the effects of elevated soil concentrations of natural gas on overlying vegetation. Pot-scale investigations were carried out to determine whether changes in spectral characteristics were specific to natural gas or were a generic response to soil-oxygen displacement. Natural gas, argon, ...

  2. Acute respiratory distress syndrome--two decades later.

    OpenAIRE

    Cunningham, A. J.

    1991-01-01

    Twenty years have now elapsed since Ashbaugh and Petty first described the syndrome of acute respiratory failure associated with a wide spectrum of clinical conditions. During the past two decades, significant advances have emerged in our understanding of the clinical conditions associated with the syndrome and the pathophysiological changes affecting the alveolar-capillary membrane responsible for the characteristic non-cardiogenic pulmonary edema. Recent data have reaffirmed the notion that...

  3. Leak detection using the pattern of sound signals in water supply systems

    Science.gov (United States)

    Sato, Toshitaka; Mita, Akira

    2007-04-01

    Water supply systems in Japan contribute significantly to improve public health. Unfortunately, there are many age-deteriorated pipes of various sizes and leaks frequently occur. Particularly devastating are hidden leaks occurring underground because when left undetected for years these leaks result in secondary damage. Thus, early detection and treatment of leaks is an important civil engineering challenge. At present the acoustic method is the most popular leak detection method. The purpose of this study is to propose an easy and stable leak detection method using the acoustic method assisted by pattern recognition techniques. In the proposed method we collect in the form of digital signals sound and pseudo-sound samples of underground leaking pipes. Principal component analysis (PCA) of the power spectrum of one leak sound is made, and a new coordinate system is constructed. We project the other sounds in the coordinate system, and evaluate if the sounds are similar to the sample sound or not by comparing the residual between the original and the projection. Next, we evaluate the DSF (Damage Sensitive Feature), which is a function of the first three AR model. At last, the feature vectors are created by combining the residuals, the DSF, and the damping ratio of the AR model, and a leak detection method is proposed using the Support Vector Machine (SVM) based upon them. In this study, it is shown that the residual and DSF are useful indices for leak detection. Furthermore, the proposed method shows high accuracy in recognizing leaks.

  4. Capillary zone electrophoresis and capillary isotachophoresis applied to physicochemical characterization of oligo- and polypeptides

    Czech Academy of Sciences Publication Activity Database

    Kašička, Václav; Šolínová, Veronika; Tůmová, Tereza; Koval, Dušan; Ibrahim, A.; Chamieh, J.; Cottet, H.

    Helsinki: -, 2015. L4B. [International Symposium on Electro- and Liquid Phase-Separation Techniques (ITP2015) /22./ and Nordic Separation Science Symposium (NoSSS2015) /8./. 30.08.2015-03.09.2015, Helsinki] R&D Projects: GA ČR(CZ) GA13-17224S Institutional support: RVO:61388963 Keywords : capillary electrophoresis * capillary isotachophoresis * effective charge Subject RIV: CB - Analytical Chemistry, Separation

  5. Capillary isoelectric focusing of proteins and microorganisms in uncoated capillaries with UV and fluorimetric detection

    Czech Academy of Sciences Publication Activity Database

    Horká, Marie; Šlais, Karel; Růžička, F.; Holá, V.; Horký, J.

    Roma : Universita di Roma, 2004, P43. [ITP 2004. International Symposium on Capillary Electroseparation Techniques /14./. Roma (IT), 12.09.2004-15.09.2004] R&D Projects: GA AV ČR IAA4031302; GA AV ČR IBS4031201; GA ČR GA203/02/1447 Institutional research plan: CEZ:AV0Z4031919 Keywords : CIEF ioanalytes * uncoated capillaries Subject RIV: CB - Analytical Chemistry, Separation

  6. Testing underground tanks for leak tightness at LLNL

    International Nuclear Information System (INIS)

    Two types of tank systems are present at the Livermore Site: tanks and associated piping for the storage of fuel (forty-three systems), and tanks or sumps and associated piping for the retention of potentially contaminated wastewater (forty systems). The fuel systems were tested using commercially available test methods: Petro-Tite, Hunter Leak Lokator, Ezy-Chek, and Associated Environmental Systems (A.E.S.). In contrast to fuel tank systems, wastewater systems have containers that are predominantly open at the top and not readily testable. Therefore, a project to test and evaluate all available testing methods was initiated and completed. The commercial method Tank Auditor was determined to be appropriate for testing open-top tanks and sumps and this was the method used to test the majority of the open-top containers. Of the 81 tanks tested, 61 were found to be leak tight, 9 were shown to have leaks, and 11 yielded inconclusive results. Two tanks have not yet been tested because of operational constraints; they are sheduled to be tested within the next two months. Schedules are being developed for the retesting of tanks and for remedial actions

  7. Management of a water leak on actively cooled fusion devices

    International Nuclear Information System (INIS)

    ITER will be the most important machine equipped with actively cooled plasma facing components (PFCs). In case of abnormal events during a discharge, the PFC will be submitted to localized transient phenomena (high power densities, run away electrons, etc.), leading, in the worst case, to the degradation of the PFC wall and possibly to a water leak. In any case, a leak will have important consequences for the PFCs and equipment located in the vacuum vessel or connected to the ports such as seals, pumping systems or diagnostics. Considerable experience of these events has been gained at Tore Supra over a period of more than 10 years [J.J. Cordier, Ten years of maintenance on Tore Supra actively cooled components, in: Proceedings of the 21th Symp. of Fusion Technology (SOFT), Madrid, Spain, September, 2000.], which will be useful for the next step machines. This paper describes for each leak size type the procedures for maintaining save conditions in the vacuum vessel. It also presents the methods used at Tore Supra to drain-off the primary loop circuits and to identify the leaky PFC

  8. MWTF jumper connector integral seal block development and leak testing

    International Nuclear Information System (INIS)

    In fiscal year 1993, tests of an o-ring/tetraseal retainer designed to replace a gasket-type seal used in PUREX-type process jumper connectors encouraged the design of an improved seal block. This new seal block combines several parts into one unitized component called an integral seal block. This report summarizes development and leak testing of the new integral seal block. The integral seal block uses a standard o-ring nested in a groove to accomplish leak tightness. This seal block eliminates the need to machine acme threads into the lower skirt casting and seal retainers, eliminates tolerance stack-up, reduces parts inventory, and eliminates an unnecessary leak path in the jumper connector assembly. This report also includes test data on various types of o-ring materials subjected to heat and pressure. Materials tested included Viton, Kalrez, and fluorosilicone, with some incidental data on teflon coated silicone o-rings. Test experience clearly demonstrates the need to test each seal material for temperature and pressure in its intended application. Some materials advertised as being open-quotes betterclose quotes at higher temperatures did not perform up to expectations. Inspection of the fluorosilicone and Kalrez seals after thermal testing indicates that they are much more susceptible to heat softening than Viton

  9. Pipe fracture evaluations for leak-rate detection: Probabilistic models

    International Nuclear Information System (INIS)

    This is the second in series of three papers generated from studies on nuclear pipe fracture evaluations for leak-rate detection. This paper focuses on the development of novel probabilistic models for stochastic performance evaluation of degraded nuclear piping systems. It was accomplished here in three distinct stages. First, a statistical analysis was conducted to characterize various input variables for thermo-hydraulic analysis and elastic-plastic fracture mechanics, such as material properties of pipe, crack morphology variables, and location of cracks found in nuclear piping. Second, a new stochastic model was developed to evaluate performance of degraded piping systems. It is based on accurate deterministic models for thermo-hydraulic and fracture mechanics analyses described in the first paper, statistical characterization of various input variables, and state-of-the-art methods of modem structural reliability theory. From this model. the conditional probability of failure as a function of leak-rate detection capability of the piping systems can be predicted. Third, a numerical example was presented to illustrate the proposed model for piping reliability analyses. Results clearly showed that the model provides satisfactory estimates of conditional failure probability with much less computational effort when compared with those obtained from Monte Carlo simulation. The probabilistic model developed in this paper will be applied to various piping in boiling water reactor and pressurized water reactor plants for leak-rate detection applications

  10. Liquid metal-to-gas leak-detection instruments

    International Nuclear Information System (INIS)

    It is desirable for liquid-metal-cooled reactors that small liquid metal-to-gas leaks be reliably detected. Testing has been performed on a number of detection systems to evaluate their sensitivity, response time, and performance characteristics. This testing has been scheduled in three phases. The first phase was aimed at screening out the least suitable detectors and optimizing the performance of the most promising. In the second phase, candidates were tested in a 1500 ft3 walk-in type enclosure in which leaks were simulated on 24-in. and 3-in. piping. In the third phase of testing, selected type detectors were tested in the 1500-ft3 enclosure with Clinch River Breeder Reactor Plant (CRBRP) pipe insulation configurations and detector tubing configuration with cell gas recirculation simulated. Endurance testing of detection equipment was also performed as part of this effort. Test results have been shown that aerosol-type detectors will reliably detect leaks as small as a few grams per hour when sampling pipe insulation annuli

  11. Pleuroperitoneal Leak Complicating Peritoneal Dialysis: A Case Series

    Directory of Open Access Journals (Sweden)

    C. Kennedy

    2011-01-01

    Full Text Available Pressure related complications such as abdominal wall hernias occur with relative frequency in patients on peritoneal dialysis. Less frequently, a transudative pleural effusion containing dialysate can develop. This phenomenon appears to be due to increased intra-abdominal pressure in the setting of congenital or acquired diaphragmatic defects. We report three cases of pleuroperitoneal leak that occurred within a nine-month period at our institution. We review the literature on this topic, and discuss management options. The pleural effusion resolved in one patient following drainage of the peritoneum and a switch to haemodialysis. One patient required emergency thoracocentesis. The third patient developed a complex effusion requiring surgical intervention. The three cases highlight the variability of this condition in terms of timing, symptoms and management. The diagnosis of a pleuroperitoneal leak is an important one as it is managed very differently to most transudative pleural effusions seen in this patient population. Surgical repair may be necessary in those patients who wish to resume peritoneal dialysis, or in those patients with complex effusions. Pleuroperitoneal leak should be considered in the differential diagnosis of a pleural effusion, particularly a right-sided effusion, in a patient on peritoneal dialysis.

  12. Pleuroperitoneal leak complicating peritoneal dialysis: a case series.

    LENUS (Irish Health Repository)

    Kennedy, C

    2012-02-01

    Pressure related complications such as abdominal wall hernias occur with relative frequency in patients on peritoneal dialysis. Less frequently, a transudative pleural effusion containing dialysate can develop. This phenomenon appears to be due to increased intra-abdominal pressure in the setting of congenital or acquired diaphragmatic defects. We report three cases of pleuroperitoneal leak that occurred within a nine-month period at our institution. We review the literature on this topic, and discuss management options. The pleural effusion resolved in one patient following drainage of the peritoneum and a switch to haemodialysis. One patient required emergency thoracocentesis. The third patient developed a complex effusion requiring surgical intervention. The three cases highlight the variability of this condition in terms of timing, symptoms and management. The diagnosis of a pleuroperitoneal leak is an important one as it is managed very differently to most transudative pleural effusions seen in this patient population. Surgical repair may be necessary in those patients who wish to resume peritoneal dialysis, or in those patients with complex effusions. Pleuroperitoneal leak should be considered in the differential diagnosis of a pleural effusion, particularly a right-sided effusion, in a patient on peritoneal dialysis.

  13. PRACTICAL IMPLICATIONS OF USING INDUCED TRANSIENTS FOR LEAK DETECTION

    Directory of Open Access Journals (Sweden)

    Marko V. Ivetic

    2007-06-01

    Full Text Available This paper deals with practical problems of leak detection by methods based on hydraulic transient analysis. Controlled and safe transients can be generated and the response of the network, with the relevant information, can be monitored and analysed. Information about leaks, contained in the monitored pressure signal, cannot be easily retrieved, due to reflections, noise etc. On the basis of numerical experiments on a simple network, merits and limitations of several methods for signal analysis (time domain analysis, spectral density function and wavelet transform have been examined. Certain amount of information can be extracted from the time history of the pressure signal, assuming the first reflection of the pressure wave is captured with very high time resolution and accuracy. Only relatively large leaks can be detected using this methodology. As a way to increase the sensitivity of this method it is suggested that transforms in frequency domain and, especially, wavelet transforms, are used. The most promising method for leakage location and quantification seems to be based on wavelet analysis.

  14. Electrical detection of liquid lithium leaks from pipe joints

    International Nuclear Information System (INIS)

    A test stand for flowing liquid lithium is under construction at Princeton Plasma Physics Laboratory. As liquid lithium reacts with atmospheric gases and water, an electrical interlock system for detecting leaks and safely shutting down the apparatus has been constructed. A defense in depth strategy is taken to minimize the risk and impact of potential leaks. Each demountable joint is diagnosed with a cylindrical copper shell electrically isolated from the loop. By monitoring the electrical resistance between the pipe and the copper shell, a leak of (conductive) liquid lithium can be detected. Any resistance of less than 2 kΩ trips a relay, shutting off power to the heaters and pump. The system has been successfully tested with liquid gallium as a surrogate liquid metal. The circuit features an extensible number of channels to allow for future expansion of the loop. To ease diagnosis of faults, the status of each channel is shown with an analog front panel LED, and monitored and logged digitally by LabVIEW

  15. Electrical detection of liquid lithium leaks from pipe jointsa)

    Science.gov (United States)

    Schwartz, J. A.; Jaworski, M. A.; Mehl, J.; Kaita, R.; Mozulay, R.

    2014-11-01

    A test stand for flowing liquid lithium is under construction at Princeton Plasma Physics Laboratory. As liquid lithium reacts with atmospheric gases and water, an electrical interlock system for detecting leaks and safely shutting down the apparatus has been constructed. A defense in depth strategy is taken to minimize the risk and impact of potential leaks. Each demountable joint is diagnosed with a cylindrical copper shell electrically isolated from the loop. By monitoring the electrical resistance between the pipe and the copper shell, a leak of (conductive) liquid lithium can be detected. Any resistance of less than 2 kΩ trips a relay, shutting off power to the heaters and pump. The system has been successfully tested with liquid gallium as a surrogate liquid metal. The circuit features an extensible number of channels to allow for future expansion of the loop. To ease diagnosis of faults, the status of each channel is shown with an analog front panel LED, and monitored and logged digitally by LabVIEW.

  16. Electrical detection of liquid lithium leaks from pipe joints.

    Science.gov (United States)

    Schwartz, J A; Jaworski, M A; Mehl, J; Kaita, R; Mozulay, R

    2014-11-01

    A test stand for flowing liquid lithium is under construction at Princeton Plasma Physics Laboratory. As liquid lithium reacts with atmospheric gases and water, an electrical interlock system for detecting leaks and safely shutting down the apparatus has been constructed. A defense in depth strategy is taken to minimize the risk and impact of potential leaks. Each demountable joint is diagnosed with a cylindrical copper shell electrically isolated from the loop. By monitoring the electrical resistance between the pipe and the copper shell, a leak of (conductive) liquid lithium can be detected. Any resistance of less than 2 kΩ trips a relay, shutting off power to the heaters and pump. The system has been successfully tested with liquid gallium as a surrogate liquid metal. The circuit features an extensible number of channels to allow for future expansion of the loop. To ease diagnosis of faults, the status of each channel is shown with an analog front panel LED, and monitored and logged digitally by LabVIEW. PMID:25430389

  17. Leak injection/detection input for B and W prototype steam generator test request

    International Nuclear Information System (INIS)

    The goal of the leak injection/detection phase of the test program on the prototype steam generator is to obtain data that can be used to specify the leak protection system for the plant unit steam generators. Both chemical and two acoustic leak detection methods (by GE and Rockwell International) are to be considered. The chemical system has been selected as the reference based on its more developed state. The acoustic methods have potential both as small leak detection systems and as intermediate leak protection/automatic shutdown systems. Simulated leak injections will be made at various locations within the steam generator to determine the performance of the chemical system as specifically applied to the B and W helical coil steam generator geometry. Acoustic tests will be made to characterize the various steam generator background noise sources and to record acoustic signals during smulated leak injections, in order to predict the performance of both systems

  18. Kindler syndrome

    Directory of Open Access Journals (Sweden)

    Kaviarasan P

    2005-01-01

    Full Text Available Kindler syndrome is a rare autosomal recessive disorder associated with skin fragility. It is characterized by blistering in infancy, photosensitivity and progressive poikiloderma. The syndrome involves the skin and mucous membrane with radiological changes. The genetic defect has been identified on the short arm of chromosome 20. This report describes an 18-year-old patient with classical features like blistering and photosensitivity in childhood and the subsequent development of poikiloderma. The differential diagnosis of Kindler syndrome includes diseases like Bloom syndrome, Cockayne syndrome, dyskeratosis congenita, epidermolysis bullosa, Rothmund-Thomson syndrome and xeroderma pigmentosum. Our patient had classical cutaneous features of Kindler syndrome with phimosis as a complication.

  19. Fat Embolism Syndrome

    Directory of Open Access Journals (Sweden)

    Gabdullin М.М.

    2012-03-01

    Full Text Available The characteristics of fat embolism syndrome (FES, and the complications occurring in fractures of long bones or pelvic bones are considered. Clinical picture classically develops after “lucid space“, then appear pulmonary and neurological manifestations combined with petechial hemorrhage. Basic theories of FES pathophysiology are analyzed. Early signs are likely to be caused by mechanic vascular occlusion by fat globules. Vascular occlusions in FES are frequently temporary or partial as fat globules block capillary blood flow incompletely due to their flowability and deformity. The diagnosis is made based on clinical presentations using A.R. Gurd’s criteria (1970. Laboratory and instrumental methods are used for clinical diagnosis confirmation or therapy monitoring. The treatment is aimed mainly at supporting respiratory function and hemodynamics stabilization. Prevention, early diagnosis and adequate symptomatic treatment are of primary importance.

  20. In service monitoring and servicing after leak detection for the LMFBR steam generators of Phenix and Superphenix

    International Nuclear Information System (INIS)

    Great care must be taken to minimize the probability of leaks within LMFBR steam generators. In this paper, the following topics are discussed: leak prevention; description of monitoring devices (hydrogen monitoring, acoustic monitoring) and protection devices; automatic and manual actions; leak localization (with or without sodium dumping); post-leak inspection and repair

  1. Capillary Interactions between a Probe Tip and a Nanoparticle

    Institute of Scientific and Technical Information of China (English)

    SUN Li-Ning; WANG Le-Feng; RONG Wei-Bin

    2008-01-01

    To understand capillary interactions between probe tips and nanoparticles under ambient conditions,a theoretical model of capillary forces between them is developed based on the geometric relations. It is found that the contribution of surface tension force to the total capillary force attains to similar order of magnitude as the capillary pressure force in many cases.It is also shown that the tip shape and the radial distance of the meniscus have great influence on the capillary force.The capillary force decreases with the increasing separation distances,and the variance of the contact angles may change the magnitudes of capillary forces several times at large radial distances.The applicability of the symmetric meniscus approximation is discussed.

  2. Capillary Penetration into Inclined Circular Glass Tubes.

    Science.gov (United States)

    Trabi, Christophe L; Ouali, F Fouzia; McHale, Glen; Javed, Haadi; Morris, Robert H; Newton, Michael I

    2016-02-01

    The spontaneous penetration of a wetting liquid into a vertical tube against the force of gravity and the imbibition of the same liquid into a horizontal tube (or channel) are both driven by capillary forces and described by the same fundamental equations. However, there have been few experimental studies of the transition from one orientation to the other. We report systematic measurements of capillary penetration of polydimethylsiloxane oils of viscosities 9.6, 19.2, and 48.0 mPa·s into glass capillary tubes. We first report the effect of tube radii R between 140 and 675 μm on the dynamics of spontaneous imbibition. We show that the data can be fitted using the exact numerical solution to the governing equations and that these are similar to fits using the analytical viscogravitational approximation. However, larger diameter tubes show a rate of penetration slower than expected using an equilibrium contact angle and the known value of liquid viscosity. To account for the slowness, an increase in viscosity by a factor (η/ρ)scaling is needed. We show full agreement with theory requires the ratio R/κ(-1) ∼ 0.1 or less, where κ(-1) is the capillary length. In addition, we propose an experimental method that enables the determination of the dynamic contact angle during imbibition, which gives values that agree with the literature values. We then report measurements of dynamic penetration into the tubes of R = 190 and 650 μm for a range of inclination angles to the horizontal, φ, from 5 to 90°. We show that capillary penetration can still be fitted using the viscogravitational solution, rather than the Bosanquet solution which describes imbibition without gravity, even for inclination angles as low as 10°. Moreover, at these low angles, the effect of the tube radius is found to diminish and this appears to relate to an effective capillary length, κ(-1)(φ) = (γLV/ρg sin φ)(1/2). PMID:26738739

  3. A novel covalent coating of capillaries for capillary electrophoresis coupled to matrix assisted laser desorption ionization

    International Nuclear Information System (INIS)

    Capillary electrophoresis (CE) offers the advantage of flexibility and method development. It excels in the area of separation of ions, chiral, polar, and biological compounds (especially proteins and peptides). Masking the active sites on the inner surface of a bare fused-silica capillary wall is often necessary for CE separations of basic compounds, proteins and peptides. The use of capillary surface coatings is an approach to prevent adsorption phenomena and improve the repeatability of these analytes. In this work, new capillary coatings consisting of (I) derivatized polystyrene nanoparticles (PS) and (II) derivatized fullerenes, were investigated for the analysis of peptides and protein digest by CE. The coated capillaries showed excellent run-to-run and batch-to-batch reproducibility (RSD of migration time ≤ 0.5 % for run to run and ≤ 9.5 % for batch-to-batch experiments). Furthermore, the capillaries offer high stability from pH 2.0 up to pH 10.0. The actual potential of the coated capillaries was tested by combining CE with matrix-assisted laser desorption ionisation (MALDI) mass spectrometry (MS) for analysing complex samples, such as peptides, whereas the overall performance of the CE-MALDI-TOF-MS system was investigated by analysing a five protein digest mixture. Subsequently, the peak list (peptide mass fingerprint) generated from the mass spectra of each fraction was entered into the Swiss Prot database in order to search for matching tryptic fragments using the Mascot software. The sequence coverage of analysed proteins was between 36-68%. The established technology benefits from the synergism of high separation efficiency and the structure selective identification via MS. (author)

  4. New alarm system approach for detection and location of small leaks from pipelines

    International Nuclear Information System (INIS)

    Vapor Monitoring Wells are an accepted method to monitor for leaks from underground storage tanks and pipe. This paper discusses a method that is similar to well leak detection technique, yet superior for pipelines for reasons to be defined. Vapors from a leak source migrate through the soil. The time required for a leak to migrate a known distance is dependent on the vapor pressure of the leaking substance, the leak rate, and finally, soil type, compaction, and collection device is to the leak source the shorter the time required for the premise that the sensor tube acts as a continuous row of wells that can all be automatically sampled with one central pump/detector. The system precisely locates the leak. The benefit of this system is earlier detection and location of small leaks to minimize product loss to the environment. Dr. Wolfgang Issel developed Leak Alarm System for Pollutants, LASP, with the support of the German Ministry of Research and Technology to protect groundwater and other environmentally sensitive zones

  5. Structural mechanical and thermal hydraulic aspects on the behaviour of crack like leaks in piping

    Energy Technology Data Exchange (ETDEWEB)

    Sievers, J.; Heckmann, K.; Grebner, H. [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), Koeln (Germany); Moner, G.P.; Lerchl, G. [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), Garching (Germany)

    2013-07-01

    The evaluation of fluid flow rates through crack-like leaks in pressurized components plays an important role for leak-before-break considerations. Thermal hydraulic and structural mechanical analyses were performed for a postulated leak in the surge line (SL) of a PWR type Konvoi under design basis accident conditions. The leak was postulated in form of a circumferential through-wall crack of 180 degrees length. The size of the leak was calculated in the framework of FE-calculations with the code ADINA using an analysis model of a cooling loop of type Konvoi. With the calculated leak size, an ATHLET calculation was conducted, also examining the influence of the consideration of a variable leak size. In the investigated case the implication of the decreasing leak size, especially on the pressure distribution, cannot be neglected. The reduction of the leak area due to both the pressure and temperature decrease in case of a leak assumed approximately in the middle of the surge line between both connection points to the hot leg and the pressurizer amounts in the transient examined to ca. 25 % after about 1 h and leads therefore also to an approximately 33 % smaller leak rate. Concerning the determination of the leak rates as critical flow-through rates with simplified methods according to Pana and the CDR-model (critical discharge) of the ATHLET code, good agreement has been achieved although the approaches differ considerably in parts. Relevant influence factors are the assumptions for the treatment of inflow losses in the crack channel, the consideration of the leak area in connection with the hydraulic diameter and the assumptions on the flow resistance coefficient due to the roughness of the crack surfaces. (orig.)

  6. a Comprehensive Model for Capillary Pressure Difference across a Drop/bubble Flowing Through a Constricted Capillary

    Science.gov (United States)

    Liang, Mingchao; Wei, Junhong; Han, Hongmei; Fu, Chengguo; Liu, Jianjun

    2015-09-01

    The capillary pressure is one of the crucial parameters in many science and engineering applications such as composite materials, interface science, chemical engineering, oil exploration, etc. The drop/bubble formation and its mechanisms that affect the permeability of porous media have steadily attracted much attention in the past. When a drop/bubble moves from a larger capillary to a smaller one, it is often obstructed by an additional pressure difference caused by the capillary force. In this paper, a comprehensive model is derived for the capillary pressure difference when a drop/bubble flows through a constricted capillary, i.e. a geometrically constricted passage with an abrupt change in radius. The proposed model is expressed as a function of the smaller capillary radius, pore-throat ratio, contact angle, surface tension and length of the drop/bubble in the smaller capillary. The model predictions are compared with the available experimental data, and good agreement is found between them.

  7. Transversally periodic solitary gravity-capillary waves.

    Science.gov (United States)

    Milewski, Paul A; Wang, Zhan

    2014-01-01

    When both gravity and surface tension effects are present, surface solitary water waves are known to exist in both two- and three-dimensional infinitely deep fluids. We describe here solutions bridging these two cases: travelling waves which are localized in the propagation direction and periodic in the transverse direction. These transversally periodic gravity-capillary solitary waves are found to be of either elevation or depression type, tend to plane waves below a critical transverse period and tend to solitary lumps as the transverse period tends to infinity. The waves are found numerically in a Hamiltonian system for water waves simplified by a cubic truncation of the Dirichlet-to-Neumann operator. This approximation has been proved to be very accurate for both two- and three-dimensional computations of fully localized gravity-capillary solitary waves. The stability properties of these waves are then investigated via the time evolution of perturbed wave profiles. PMID:24399922

  8. Capillary droplets on Leidenfrost micro-ratchets

    CERN Document Server

    Marin, Alvaro G; Römer, Gertwillem R B E; Pathiraj, B; Veld, Albertus Huis in 't; Lohse, Detlef

    2012-01-01

    Leidenfrost ratchets are structures with the ability of transporting liquid droplets when heated over the critical Leidenfrost temperature. Once this temperature is reached, the droplet levitates over the surface and moves in the direction marked by the slope of the ratchet at terminal velocities around 10 cm/s. Here we provide new experiments with micron-sized ratchets, which have been produced with picosecond pulse laser ablation. In the following work, we use a simple method to measure the thrust driving droplets of capillary size over the micro-ratchets. The mechanism responsible for the force acting on the drop on superheated ratchets has been recently under debate. We extend the recently proposed 'viscous mechanism' proposed by Dupeaux et al. [Europhys. Lett., 96, 58001 (2011)] to capillary droplets and find good agreement with our measurements.

  9. Capillary flow through heat-pipe wicks

    Science.gov (United States)

    Eninger, J. E.

    1975-01-01

    Theoretical expressions are obtained for the capillary-pressure limit and permeability of a fibrous wick in terms of the porosity and fiber diameter. Hysteresis in capillary pressure is included through the introduction of an empirical hysteresis constant. A partial-saturation model based on the statistical distribution of local porosity requires an additional empirical constant, the standard deviation. The theory is compared to results of a beta-ray absorption experiment that measured the liquid content of a partially saturated wick and to results of permeability measurements on partially and fully saturated wicks. A simple wick-weighing experiment is described that yields values for the empirical hysteresis constant and the standard deviation. Theoretical results are used to design an optimum wick.

  10. Capillary Hemangioma of the Fallopian Tube.

    Science.gov (United States)

    Katiyar, Richa; Patne, Shashikant C U; Bharti, Shreekant; Jain, Madhu

    2016-04-01

    Neoplastic lesions of the fallopian tube are rarely seen by surgical pathologists. Haemangioma of the fallopian tube is an extremely rare benign neoplasm. A 30-year-old lady with polymenorrhea and dysmenorrhea underwent hysterectomy and bilateral salpingo-oophorectomy. Her left fallopian tube showed a 2mm sized solid nodule in the wall. Histopathological examination revealed a well-defined vascular lesion in the left fallopian tube, consistent with capillary haemangioma. The vascular endothelium was highlighted by CD34 immunostaining. Our literature review has identified 10 cases of cavernous haemangioma of the fallopian tube. To the best of our knowledge, we report the first ever case of capillary haemangioma of the fallopian tube. This is also the smallest detected haemangioma in the fallopian tube. PMID:27190899

  11. Chemical Power for Microscopic Robots in Capillaries

    CERN Document Server

    Hogg, Tad

    2009-01-01

    The power available to microscopic robots (nanorobots) that oxidize bloodstream glucose while aggregated in circumferential rings on capillary walls is evaluated with a numerical model using axial symmetry and time-averaged release of oxygen from passing red blood cells. Robots about one micron in size can produce up to several tens of picowatts, in steady-state, if they fully use oxygen reaching their surface from the blood plasma. Robots with pumps and tanks for onboard oxygen storage could collect oxygen to support burst power demands two to three orders of magnitude larger. We evaluate effects of oxygen depletion and local heating on surrounding tissue. These results give the power constraints when robots rely entirely on ambient available oxygen and identify aspects of the robot design significantly affecting available power. More generally, our numerical model provides an approach to evaluating robot design choices for nanomedicine treatments in and near capillaries.

  12. The geometry and wetting of capillary folding

    CERN Document Server

    Péraud, Jean-Philippe

    2014-01-01

    Capillary forces are involved in a variety of natural phenomena, ranging from droplet breakup to the physics of clouds. The forces from surface tension can also be exploited in industrial application provided the length scales involved are small enough. Recent experimental investigations showed how to take advantage of capillarity to fold planar structures into three-dimensional configurations by selectively melting polymeric hinges joining otherwise rigid shapes. In this paper we use theoretical calculations to quantify the role of geometry and fluid wetting on the final folded state. Considering folding in two and three dimensions, studying both hydrophilic and hydrophobic situations with possible contact angle hysteresis, and addressing the shapes to be folded to be successively infinite, finite, curved, kinked, elastic, we are able to derive an overview of the geometrical parameter space available for capillary folding.

  13. Capillary solitons on a levitated medium.

    Science.gov (United States)

    Perrard, S; Deike, L; Duchêne, C; Pham, C-T

    2015-07-01

    A water cylinder deposited on a heated channel levitates on its own generated vapor film owing to the Leidenfrost effect. This experimental setup permits the study of the one-dimensional propagation of surface waves in a free-to-move liquid system. We report the observation of gravity-capillary waves under a dramatic reduction of gravity (up to a factor 30), leading to capillary waves at the centimeter scale. The generated nonlinear structures propagate without deformation and undergo mutual collisions and reflections at the boundaries of the domain. They are identified as Korteweg-de Vries solitons with negative amplitude and subsonic velocity. The typical width and amplitude-dependent velocities are in excellent agreement with theoretical predictions based on a generalized Korteweg-de Vries equation adapted to any substrate geometry. When multiple solitons are present, they interact and form a soliton turbulencelike spectrum. PMID:26274114

  14. EUV radiation from nitrogen capillary discharge

    Czech Academy of Sciences Publication Activity Database

    Frolov, Oleksandr; Koláček, Karel; Štraus, Jaroslav; Schmidt, Jiří

    Vol. 32. Singapore: World Scientific Publishing Co, 2014, "1460329-1 "-"1460329-7". ISSN 2010-1945. [International Conference on Plasma Science and Applications, ICPSA 2013. Singapore (SG), 04.12.2013-06.12.2013] R&D Projects: GA MŠk(CZ) LG13029 Institutional support: RVO:61389021 Keywords : EUV radiation * capillary discharge * EUV source * Z-pinch Subject RIV: BL - Plasma and Gas Discharge Physics http://www. world scientific.com/doi/abs/10.1142/S2010194514603299

  15. Electrical resistance of muscle capillary endothelium.

    OpenAIRE

    Olesen, S P; Crone, C

    1983-01-01

    A recently developed technique for in vivo determination of the electrical resistance of vascular endothelium in microvessels was applied to the vessels in a thin frog muscle, m. cutaneus pectoris. The technique consists of injection of current via a glass micropipette into a capillary and measurement of the resulting intra- and extravascular potential profiles with another micropipette placed at various distances from the current source. The theory of Peskoff and Eisenberg (1974) was used to...

  16. Capillary Electrophoresis in the Presence of Fosfomycin

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Fosfomyein, a sodim salt of cis-(3-methyloxiranyl) phosphonic acid, was used as electrolyte in binary methanol-water media for capillary electrophoresis. The variety of electroosmotic flow with pH*,methanol concentration and ionic strength was investigated. The migration behavior of nine bases was examined under various conditions, and the separation of thymine, cytosine, 5-flurouracil, 4,6-diamino-pyrimidine, purine was accomplished.

  17. Subsidence and capillary effects in chalks

    OpenAIRE

    Delage, Pierre; Schroeder, Christian; Cui, Yu-Jun

    1996-01-01

    Based on the concepts of the mechanics of unsaturated soils where capillary phenomena arise between the wetting fluid (water) and the non-wetting one (air), the subsidence of chalks containing oil (non-wetting fluid) during water injection (wetting fluid) is analysed. It is shown that the collapse phenomenon of unsaturated soils under wetting provides a physical explanation and a satisfactory prediction of the order of magnitude of the subsidence of the chalk. The use of a well established co...

  18. Identifying kinetically stable proteins with capillary electrophoresis

    OpenAIRE

    Zhang, Songjie; Xia, Ke; Chung, Wai Keen; Cramer, Steven M; Colón, Wilfredo

    2010-01-01

    Unlike most proteins, which are in equilibrium with partially and globally unfolded conformations, kinetically stable proteins (KSPs) are trapped in their native conformations and are often resistant to harsh environment. Based on a previous correlation between kinetic stability (KS) and a protein's resistance to sodium dodecyl sulfate (SDS), we show here a simple method to identify KSPs by SDS-capillary electrophoresis (CE). Control non-KSPs were fully denatured by SDS and formed protein:SDS...

  19. Separation of Peptides by Pressurized Capillary Electrochromatography

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    A novel gradient pressurized capillary electrochromatography (pCEC) instrument wasdeveloped to separate peptides. Two gradient elution modes, hydrophobic and hydrophilicinteraction mode in pCEC, were performed on this instrument. Baseline separation of sixpeptides was obtained on two gradient modes with C18 column and strong cationic exchangecolumn respectively. The effects of mixer volume and total flow rate of pumps on resolutionwere also discussed.

  20. Hydrogen peroxide production in capillary underwater discharges

    Czech Academy of Sciences Publication Activity Database

    De Baerdemaeker, F.; Šimek, Milan; Leys, C.

    2007-01-01

    Roč. 40, č. 9 (2007), s. 2801-2809. ISSN 0022-3727 R&D Projects: GA AV ČR IAA1043403 Institutional research plan: CEZ:AV0Z20430508 Keywords : water breakdown * capillary * AC discharge * conductive liquid * hydrogen peroxide formation * initial rate * energy yield Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 2.200, year: 2007

  1. Hydrogen peroxide production in capillary underwater discharges

    Czech Academy of Sciences Publication Activity Database

    De Baerdemaeker, F.; Šimek, Milan; Člupek, Martin; Lukeš, Petr; Leys, C.

    2006-01-01

    Roč. 56, suppl. B (2006), s. 1132-1139. ISSN 0011-4626. [Symposium on Plasma Physics and Technology/22nd./. Praha, 26.6.2006-29.6.2006] R&D Projects: GA AV ČR(CZ) IAA1043403 Institutional research plan: CEZ:AV0Z20430508 Keywords : water * capillary * AC discharge * hydrogen peroxide formation * initial rate Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 0.568, year: 2006

  2. Familial Pulmonary Capillary Hemangiomatosis Early in Life

    OpenAIRE

    Speer, Christian P.; Mark, Eugene J.; Johannes Wirbelauer; Alexander Marx; Helge Hebestreit

    2011-01-01

    Background. Pulmonary capillary hemangiomatosis (PCH) is a rare disease, especially in infancy. Four infants have been reported up to the age of 12 months. So far, no familial patients are observed at this age. Patients. We report three siblings, two female newborns and a foetus of 15-week gestation of unrelated, healthy parents suffering from histologically proven PCH. The first girl presented with increased O2 requirements shortly after birth and patent ductus arteriosus (PDA). She subseque...

  3. Hydrophilic polymer systems in capillary electrophoretic separations

    Czech Academy of Sciences Publication Activity Database

    Guryča, Vilém; Novotný, M. V.; Michálek, Jiří; Pacáková, V.

    Praha : Charles University, Department of Chemistry, Albertov, 2005, s. 8-12. ISBN 80-903103-1-1. [International Student Conference ‘Modern Analytical Chemistry’/2./. Praha (CZ), 26.09.2005-27.09.2005] Grant ostatní: National Institute of General Medical Sciences, U.S. Department of Health and Human Services(US) GM24349 Institutional research plan: CEZ:AV0Z40500505 Keywords : analytical glycobiology * capillary electrochromatography * hydrophilic acrylamide monoliths Subject RIV: CD - Macromolecular Chemistry

  4. Highly conductive, printable pastes from capillary suspensions

    Science.gov (United States)

    Schneider, Monica; Koos, Erin; Willenbacher, Norbert

    2016-08-01

    We have used the capillary suspension phenomenon to design conductive pastes for printed electronic applications, such as front side metallization of solar cells, without non-volatile, organic additives that often deteriorate electrical properties. Adding a small amount of a second, immiscible fluid to a suspension creates a network of liquid bridges between the particles. This capillary force-controlled microstructure allows for tuning the flow behavior in a wide range. Yield stress and low-shear viscosity can be adjusted such that long-term stability is provided by inhibiting sedimentation, and, even more importantly, narrow line widths and high aspect ratios are accessible. These ternary mixtures, called capillary suspensions, exhibit a strong degree of shear thinning that allows for conventional coating or printing equipment to be used. Finally, the secondary fluid, beneficial for stability and processing of the wet paste, completely evaporates during drying and sintering. Thus, we obtained high purity silver and nickel layers with a conductivity two times greater than could be obtained with state-of-the-art, commercial materials. This revolutionary concept can be easily applied to other systems using inorganic or even organic conductive particles and represents a fundamental paradigm change to the formulation of pastes for printed electronics.

  5. Spatial reconstruction of facial skin capillaries

    Directory of Open Access Journals (Sweden)

    Makarchuk O.I.

    2010-01-01

    Full Text Available To define structural and functional changes of skin capillaries in women of different age groups in this work intraoperational biopsy material of skin of 205 women at the age from 19 to 75 years, that was taken during standard surgery instrumentations for different defects of face and neck skin correction, was investigated. Skin material of cheek face region, temple region of head and anterior neck region was morphologically processed. To define parameters of dermal capillars and spatial reconstruction of intrapapillary capillary loops, serial sections was investigated with the help of morphometry. It was determined, that microcirculation age changes include structural disorders of intrapapillary capillary loops. Essential struc-tural and functional changes observed in skin of cheek region in women of 33-40 years and in temple region of head and anterior neck region in women of 41-50 years. It is typical at the patients with nicotinic dependence, ischemic heart disease, hypertonic disease, a diabetes, and also adiposity of a different degree essential infringement of microvessels bed structure of a skin that gives the basis for allocation of the given contingent of patients as group high intraoperative and postoperative risk at carrying out of operative interventions for correction of face skin involutive changes.

  6. The order of condensation in capillary grooves.

    Science.gov (United States)

    Rascón, Carlos; Parry, Andrew O; Nürnberg, Robert; Pozzato, Alessandro; Tormen, Massimo; Bruschi, Lorenzo; Mistura, Giampaolo

    2013-05-15

    We consider capillary condensation in a deep groove of width L. The transition occurs at a pressure p(co)(L) described, for large widths, by the Kelvin equation p(sat) - p(co)(L) = 2σ cosθ/L, where θ is the contact angle at the side walls and σ is the surface tension. The order of the transition is determined by the contact angle of the capped end θcap; it is continuous if the liquid completely wets the cap, and first-order otherwise. When the transition is first-order, corner menisci at the bottom of the capillary lead to a pronounced metastability, determined by a complementary Kelvin equation Δp(L) = 2σ sinθcap/L. On approaching the wetting temperature of the capillary cap, the corner menisci merge and a single meniscus unbinds from the bottom of the groove. Finite-size scaling shifts, crossover behaviour and critical singularities are determined at mean-field level and beyond. Numerical and experimental results showing the continuous nature of condensation for θcap = 0 and the influence of corner menisci on adsorption isotherms are presented. PMID:23611878

  7. Capillary-scale polarimetry for flowing streams.

    Science.gov (United States)

    Swinney, K; Nodorft, J; Bornhop, D J

    2001-05-01

    A micro-polarimeter with a 40 nL probe volume was configured so that it is compatible with capillary-scale flowing stream analysis. The optical configuration consists of two polarizing optics, a capillary, a laser source and a photodetector which is very simple to configure with low cost components. This unique polarimeter is based upon the interaction of a linearly polarized laser beam and a capillary tube, in this case one with an inner diameter of 250 microns. Side illumination of the tube results in a 360 degrees fan of scattered light, which contains a set of interference fringes that change in response to optically active solutes. Solutes that exhibit optical activity are quantifiable and are detected by analyzing the polarization state of the backscattered light. The ability of the instrument to make extremely sensitive optical activity measurements in flowing streams is shown by the determination of (R)-mandelic acid, with a detection limit of 66 x 10(-6) M (507 x 10(-12) g), and the non-optically active control, glycerol. Additionally, the detector was configured to minimize refractive index perturbations. PMID:11394312

  8. Intracranial contrast-enhancing masses in infants with capillary haemangioma of the head and neck: intracranial capillary haemangioma?

    Energy Technology Data Exchange (ETDEWEB)

    Tortori-Donati, P.; Fondelli, M.P.; Rossi, A. [Department of Pediatric Neuroradiology, Children`s Hospital and Scientific Institute ``Giannina Gaslini``, Genoa (Italy); Bava, G.L. [Department of Cardiovascular Surgery, Children`s Hospital and Scientific Institute ``Giannina Gaslini``, Genoa (Italy)

    1999-05-01

    Contrast-enhancing intracranial masses are rarely found in infants with extracranial capillary haemangiomas (CH). We aimed to assess their nature and progression in three patients undergoing CT and/or MRI. The changes in size of both extra- and intracranial lesions were recorded. In a fourth case, a single examination was obtained. All patients harboured one or two enhancing intracranial nodular, meningeal-based lesions. Diffuse leptomeningeal enhancement of the cerebellar surface was also seen in one, which disappeared at follow-up. In all but one of the cases, the intracranial lesions were on the same side as the extracranial CH. These lesions and the extracranial CH demonstrated parallel changes in size (suggesting that both represent CH) during follow-up of 1-2 years: the size of intracranial lesions and the extracranial CH decreased in two cases, whereas it was unchanged in the third. One patient had a persistent trigeminal artery, while another had cerebellar atrophy with high signal in the cortex on T2-weighted images. In some cases, extracranial CH are part of PHACE syndrome; the association with intracranial CH might represent a peculiar phenotype of this rare vascular phakomatosis. As extracranial CH are known to regress spontaneously in the majority of cases, a conservative approach is recommended also for presumed intracranial CH; surgery should be avoided unless follow-up studies demonstrate growth. (orig.) With 4 figs., 1 tab., 21 refs.

  9. Evaluation of Technologies for Retrieval of Waste from Leaking Tanks

    International Nuclear Information System (INIS)

    The US Department of Energy Environmental and Waste Management Tanks Focus Area selected as a strategic initiative the need to identify and develop technologies for remediation of tanks that are known or are suspected to leak. This investigation identified and evaluated technical options for single-shell tank waste retrieval applicable to retrieve waste from potentially leaking tanks. Technologies that minimize leakage use minimal water, and dry retrieval technologies were evaluated. Safety, cost, authorization basis, and schedule risks were identified for each technology to provide River Protection Program with information to evaluate technical and programmatic risk. A workshop was held to identify technology needs and solutions. These approaches grouped into five categories: those related to waste dislodging, waste conveyance, both waste dislodging and conveyance, the deployment platform, and technologies related to leak detection, monitoring, and mitigation. Based on the ranking, six technologies were selected as potential candidates for further evaluation. These items were prioritized into four technologies to recommend for further evaluation (1) Air assisted TORE(R). The TORE(R) produces a processing vortex core with the ability to convey solids at pre-determined slurry concentrations over great distances. The dry TORE(R) concept uses air to develop the vortex to fluidize dry solids. The TORE(R)the solids in a slurry transport line. (2) Sonication for waste dislodging utilizes ultrasonic energy to fracture and dislodge hard waste types such as salt cake and sludge. (3) Novel long-reach manipulators concept is to investigate novel cost effective approaches for long-reach manipulator technology. (4) Next generation crawler technology envisions a non-umbilical dislodger, possibly radio controlled and powered remotely to provide a deployment platform not affected by path, or the need to retrace steps

  10. Locating Leaks with TrustRank Algorithm Support

    OpenAIRE

    Luísa Ribeiro; Joaquim Sousa; Alfeu Sá Marques; Nuno E. Simões

    2015-01-01

    This paper presents a methodology to quantify and to locate leaks. The original contribution is the use of a tool based on the TrustRank algorithm for the selection of nodes for pressure monitoring. The results from these methodologies presented here are: (I) A sensitivity analysis of the number of pressure transducers on the quality of the final solution; (II) A reduction of the number of pipes to be inspected; and (III) A focus on the problematic pipes which allows a better office planning...

  11. Development of leak-free vessels against holes and cracks

    International Nuclear Information System (INIS)

    This paper proposes a method for obtaining the vessel, such that no fluid is leaked when holes or cracks occur, because the broken part is repaired automatically by its self-repairing mechanism. The self-repairing unit (sealant layer) is consisting of two rubber sheets with quilting processed. Polymer particles, which expand their volume in contact with water, produce the force for selfrepairing. This article first discusses a method for making the vessel, then the method is applied to a tire with large inside pressure. (author)

  12. A sipping technique to identify leaking rods in RCCAs

    International Nuclear Information System (INIS)

    This paper describes an original method developed by CEA and EDF in order to identify leaking rods in RCCAs with silver-based metallic alloy as neutron absorber material. The process consists of an etching of the absorber surface by means of a slightly aggressive solution. This involves the dissolution of a small quantity of silver in the solution. After the test, solution is recovered and sampled, and silver is dosed. A sipping prototype has been assembled, and three on-site demonstration campaigns, with one during the planned shutdown period of the plant, have proved the good reliability of the method and the industrial feasibility of this new technique. (author). 6 figs

  13. Pipeline leak detection method and control device therefor

    International Nuclear Information System (INIS)

    Leaks may be located in a pipeline by introducing into the pipeline an assembly that includes a pipe-sealing packer unit, a control unit, and a radioactive source shielded from the control unit. The control unit includes a gamma ray detector that controls the sealing and unsealing of the pipe by the packer in response to the detection of radiation exceeding a preset threshold - a detection event. The assembly is pushed through the pipeline by a relatively low fluid pressure behind it. The progress of the assembly through the pipeline may be monitored externally by a gamma ray detector

  14. Nuclear waste tank and pipeline external leak detection systems

    International Nuclear Information System (INIS)

    The development of two external waste tank and pipeline leak detection systems based on the electrical potential fields is reviewed. The Boeing system measured the distortion of an imposed ac potential field. The Battelle--Northwest system measured the change in the magnitude of the existing dc potential field generated by the cathodic protection system and the local electrochemical potential near the electrodes in the sediment. It was found that in a dry area the systems can detect as low as 200 liters of leakage. The engineering assistance to the tank farm management in assessing the suspected leakers is also presented

  15. Bottom-Fill Method for Stopping Leaking Oil Wells

    CERN Document Server

    Bloomfield, Louis A

    2010-01-01

    Hardware failure at the top of a deep underwater oil well can result in a catastrophic oil leak. The enormous pressure lifting the column of oil in that well makes it nearly impossible to stop from the top with seals or pressurization. We propose to fill the bottom of the well with dense and possibly streamlined objects that can descend through the rising oil. As they accumulate, those objects couple to the oil via viscous and drag forces and increase the oil's effective density. When its effective density exceeds that of the earth's crust, the oil will have essentially stopped flowing.

  16. In-place leak testing of multiple HEPA filter

    Energy Technology Data Exchange (ETDEWEB)

    Lee, H. K.; Hong, K. P.; Jun, Y. B.; Min, D. K.; Park, K. J.; Yang, S. Y.; Lee, E. P.; Hwang, Y. H.; Su, H. S.; Kim, K. S.; Kwon, H. M. [KAERI, Taejon (Korea, Republic of)

    2003-10-01

    In-place leak test for the filter banks with multiple high efficiency particulate air(HEPA) filters was carried in KAERI. As a result of the test, in the air flow capacity of 31,500 CMH and 22,800 CMH, penetration rate appeared to be 0.015 {approx} 0.036 %. These values satisfy the Regulatory Guide 1.14 reference, 0.05%. Although test has a complicated procedure, the testing technique was established by KAERI, and will be contributed to the safety inspection of ventilation system in nuclear facilities in the future.

  17. Towards aerial natural gas leak detection system based on TDLAS

    Science.gov (United States)

    Liu, Shuyang; Zhou, Tao; Jia, Xiaodong

    2014-11-01

    Pipeline leakage is a complex scenario for sensing system due to the traditional high cost, low efficient and labor intensive detection scheme. TDLAS has been widely accepted as industrial trace gas detection method and, thanks to its high accuracy and reasonable size, it has the potential to meet pipeline gas leakage detection requirements if it combines with the aerial platform. Based on literature study, this paper discussed the possibility of applying aerial TDLAS principle in pipeline gas leak detection and the key technical foundation of implementing it. Such system is able to result in a high efficiency and accuracy measurement which will provide sufficient data in time for the pipeline leakage detection.

  18. Quantitative risk assessment & leak detection criteria for a subsea oil export pipeline

    Science.gov (United States)

    Zhang, Fang-Yuan; Bai, Yong; Badaruddin, Mohd Fauzi; Tuty, Suhartodjo

    2009-06-01

    A quantitative risk assessment (QRA) based on leak detection criteria (LDC) for the design of a proposed subsea oil export pipeline is presented in this paper. The objective of this QRA/LDC study was to determine if current leak detection methodologies were sufficient, based on QRA results, while excluding the use of statistical leak detection; if not, an appropriate LDC for the leak detection system would need to be established. The famous UK PARLOC database was used for the calculation of pipeline failure rates, and the software POSVCM from MMS was used for oil spill simulations. QRA results revealed that the installation of a statistically based leak detection system (LDS) can significantly reduce time to leak detection, thereby mitigating the consequences of leakage. A sound LDC has been defined based on QRA study results and comments from various LDS vendors to assist the emergency response team (ERT) to quickly identify and locate leakage and employ the most effective measures to contain damage.

  19. A probabilistic approach to leak-before-break in CANDU pressure tubes

    International Nuclear Information System (INIS)

    In the CANDU reactor, the coolant passes through the core in zirconium alloy pressure tubes. A few of these pressure tubes have leaked at cracks near the rolled joint where the pressure tube is attached to the end fitting. A probabilistic methodology, and associated computer code (called MARATHON), has been developed to calculate the time from first leakage to unstable fracture in a probabilistic format. The methodology explicitly uses material property distributions, and allows the risk associated with leak-before-break to be estimated. A model of the leak detection system is included to calculate the time between leak detection and unstable fracture. The sensitivity of the risk to changing reactor conditions allows the optimization of reactor management after leak detection. Preliminary material property distributions show the probability of unstable fracture is very low, and that ample time is available to shut down the unit and locate the leaking tube. (author)

  20. Estimation of leak rates through a through-wall cracked pipes using Moody's critical flow model

    International Nuclear Information System (INIS)

    To introduce Leak-Before-Break (LBB) concept into the piping design standard of the LWR pressure boundary piping, LBB research and verification test programs are actively conducted in many nuclear electricity generating countries. It is an important subject to evaluate the leak rate through a through-wall cracked pipes for the verification of LBB. At JAERI, a leak test program has started in 1987 in order to measure leak rates of coolant through cracks in 4- and 6-inch diameter pipes and through slit specimens. Using the Moody's critical flow model, a computer program to evaluate a leak rate through a through-wall cracked pipes has been developed in order to determine the crack angle of test pipes in the leak test. This report describes the Moody's critical flow model, the outline of the computer program and the results of preliminary calculations. (author)

  1. Cushing's Syndrome

    Science.gov (United States)

    ... Cushing's syndrome, also called hypercortisolism , is a rare endocrine disorder caused by chronic exposure of the body's tissues ... removing the tumor while minimizing the chance of endocrine deficiency or long-term ... for Cushing's Syndrome Clinical Trials ...

  2. Turner Syndrome

    Science.gov (United States)

    Turner syndrome is a genetic disorder that affects a girl's development. The cause is a missing or incomplete ... t work properly. Other physical features typical of Turner syndrome are Short, "webbed" neck with folds of skin ...

  3. Metabolic Syndrome

    Science.gov (United States)

    Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. These ... doctors agree on the definition or cause of metabolic syndrome. The cause might be insulin resistance. Insulin is ...

  4. Asperger syndrome

    Science.gov (United States)

    Asperger syndrome is often considered a high functioning form of autism. It can lead to difficulty interacting socially, repeat behaviors, and clumsiness. Asperger syndrome is a part of the larger developmental disorder ...

  5. Pseudoaminopterin syndrome.

    Science.gov (United States)

    Kraoua, Lilia; Capri, Yline; Perrin, Laurence; Benmansour, Abdelmajjid; Verloes, Alain

    2012-09-01

    Pseudoaminopterin syndrome or aminopterin syndrome-like sine aminopterin (ASSA syndrome--OMIM 600325] is a rare autosomal recessive syndrome defined by characteristic dysmorphic features, skeletal defects, limb anomalies, cryptorchidism, and growth retardation. The syndrome owes its name to the fact that patients resemble the children exposed to aminopterin or to methotrexate, two dihydrofolate reductase inhibitors used for chemotherapy, or as an abortificient in early pregnancy. Ten patients have been described with pseudoaminopterin syndrome. Their phenotype is variable, and differs from the phenotype resulting from folic acid deprivation, leading to the notion that the pathogenesis may be more complex than simple vitamin deficiency. We report on an Algerian patient with pseudoaminopterin syndrome, review the previously reported cases and confirm that pseudoaminopterin syndrome does not result from a detectable contiguous gene imbalance as high resolution CGH array was normal in this child. PMID:22811276

  6. Usher Syndrome

    Science.gov (United States)

    Usher syndrome is an inherited disease that causes serious hearing loss and retinitis pigmentosa, an eye disorder ... hearing and vision. There are three types of Usher syndrome: People with type I are deaf from ...

  7. Turner Syndrome

    Science.gov (United States)

    Turner syndrome is a genetic disorder that affects a girl's development. The cause is a missing or ... t work properly. Other physical features typical of Turner syndrome are Short, "webbed" neck with folds of ...

  8. Proteus Syndrome

    Science.gov (United States)

    ... Gift Stock Gift Sunshine Society Contact Privacy Policy Proteus Syndrome Definition Common Signs Diagnostic Criteria (I have ... NIH to go with this criteria) Glossary Videos Proteus Syndrome is a condition which involves atypical growth ...

  9. Learning about Marfan Syndrome

    Science.gov (United States)

    ... genetic terms used on this page Learning About Marfan Syndrome What is Marfan syndrome? What are the ... Syndrome Additional Resources for Marfan Syndrome What is Marfan syndrome? Marfan syndrome is one of the most ...

  10. Heatable sample holder for capillary experiments

    International Nuclear Information System (INIS)

    Complete text of publication follows. The transmission of charged particles through various types of capillaries has been recently in the center of interest. The observed ion guiding phenomenon offered new possibilities for fundamental investigations, characterization of the inner walls of the insulating tube and also holds various possible applications. Thereafter an intensive experimental investigation started to understand the basic properties of the guiding for ions using several insulating materials like PET, SiO2, and Al2O3. Another viewpoint of the experiments was how the guiding effect changes with the length or with the inner diameter of the capillary. Recently guiding of slow highly charged ions through a single glass macrocapillary has been studied, showing that guiding occurs even for macroscopic dimensions. As a completely new aspect we would like to measure the temperature dependence of the ion-guiding. The investigation of the temperature dependence of the guiding gives new possibilities both for a fundamental understanding of the guiding phenomenon and applications. The guiding maybe adjustable by changing the temperature of the capillary, namely it may improve the efficiency of the guiding power. In our future experiments we try to find the answer how the ion guiding ability of an insulating capillary changes as a function of temperature. For these experiments a completely new heatable sample holder was designed (see Fig. 1). Our preliminary results shows that the ion guiding ability of the capillary strongly decreases, when the temperature of the glass is raised from 20degC (room temperature) to 80degC. Acknowledgements The financial support received from the ITS-LEIF Project (RII3 026015) is gratefully acknowledged. This work was supported by the 'Stiftung Aktion Oesterreich-Ungarn', the grant 'Bolyai' from the Hungarian Academy of Sciences, the TeT Grant no. AT-7/2007, the Hungarian National Office for Research and Technology, as well as

  11. Alagille syndrome.

    OpenAIRE

    Krantz, I D; Piccoli, D A; Spinner, N B

    1997-01-01

    Alagille syndrome (OMIM 118450) is an autosomal dominant disorder associated with abnormalities of the liver, heart, eye, skeleton, and a characteristic facial appearance. Also referred to as the Alagille-Watson syndrome, syndromic bile duct paucity, and arteriohepatic dysplasia, it is a significant cause of neonatal jaundice and cholestasis in older children. In the fully expressed syndrome, affected subjects have intrahepatic bile duct paucity and cholestasis, in conjunction with cardiac ma...

  12. A covalent modified hydrophilic capillary for enhanced capillary electrophoresis of biopolymers

    Institute of Scientific and Technical Information of China (English)

    Lian Guo Shan; Xue Yu; Yin Mao Wei; Xiao Hui Zheng; Jian Bin Zheng

    2009-01-01

    δ-Gluconolactone was covalently coupled to aminopropyl derivatized capillary,which created hydrophilic brushes on the inner wall of the capillary.The coated capillary was shown to generate a stable electroosmotic flow(EOF)in the investigated pH range of 2.0-9.0 and to suppress effectively the adsorption of proteins.And it enabled separation of some biopolymer mixtures including basic proteins,DNA and tryptic digested bovine serum albumin(BSA)within 15 min with efficiencies up to 450,000 plates/m.The intra-and inter-day reproducibility of the coating referring to the retention times of proteins were satisfactory with mean relative standard deviations(R.S.D.)of 0.8 and 1.7%,respectively.

  13. Endoscopic application of n-butyl-2-cyanoacrylate on esophagojejunal anastomotic leak: a case report

    OpenAIRE

    Angelopoulos Stamatis; Mantzoros Ioannis; Kanellos Ioannis; Vrakas Georgios; Pramateftakis Manousos-Georgios; Eleftheriades Efthymios; Lazarides Charalampos

    2011-01-01

    Abstract Introduction This case report describes an esophagojejunal anastomotic leak following total gastrectomy for gastric cancer. The leak was treated successfully with endoscopic application of n-butyl-2-cyanoacrylate. This is the first case report on the endoscopic application of cyanoacrylate alone for the treatment of an anastomotic leak. Case presentation This report describes a case of a 68-year-old Caucasian man who underwent surgery for gastric cancer. He underwent total gastrectom...

  14. Assessment of volume and leak measurements during CPAP using a neonatal lung model

    International Nuclear Information System (INIS)

    Although several commercial devices are available which allow tidal volume and air leak monitoring during continuous positive airway pressure (CPAP) in neonates, little is known about their measurement accuracy and about the influence of air leaks on volume measurement. The aim of this in vitro study was the validation of volume and leak measurement under CPAP using a commercial ventilatory device, taking into consideration the clinical conditions in neonatology. The measurement accuracy of the Leoni ventilator (Heinen and Löwenstein, Germany) was investigated both in a leak-free system and with leaks simulated using calibration syringes (2–10 ml, 20–100 ml) and a mechanical lung model. Open tubes of variable lengths were connected for leak simulation. Leak flow was measured with the flow-through technique. In a leak-free system the mean relative volume error ±SD was 3.5 ± 2.6% (2–10 ml) and 5.9 ± 0.7% (20–60 ml), respectively. The influence of CPAP level, driving flow, respiratory rate and humidification of the breathing gas on the volume error was negligible. However, an increasing FiO2 caused the measured tidal volume to increase by up to 25% (FiO2 = 1.0). The relative error ±SD of the leak measurements was −0.2 ± 11.9%. For leaks >19%, measured tidal volume was underestimated by more than 10%. In conclusion, the present in vitro study showed that the Leoni allowed accurate volume monitoring under CPAP conditions similar to neonates. Air leaks of up to 90% of patient flow were reliably detected. For an FiO2 >0.4 and for leaks >19%, a numerical correction of the displayed volume should be performed

  15. Biliary Leak in Post-Liver-Transplant Patients: Is There Any Place for Metal Stent?

    OpenAIRE

    Michel Kahaleh; Timothy Schmitt; Melissa Phillips; Gaidhane, Monica R; Martins, Fernanda P

    2012-01-01

    Objectives. Endoscopic management of bile leak after orthotopic liver transplant (OLT) is widely accepted. Preliminary studies demonstrated encouraging results for covered self-expandable metal stents (CSEMS) in complex bile leaks. Methods. Thirty-one patients with post-OLT bile leaks underwent endoscopic temporary placement of CSEMS (3 partially CSEMS , 18 fully CSEMS with fins and 10 fully CSEMS with flare ends) between December 2003 and December 2010. Long-term clinical success and safety ...

  16. Experimental investigation of the utilisation of ionisation gauges for leak detection

    CERN Document Server

    Benvenuti, C

    1972-01-01

    A description is given of a method of leak detecting applicable to the ISR (CERN) vacuum system after bakeout. This method, based on the enhanced indication of an ionisation gauge obtained when replacing the air around the leak by Argon, affords a detection efficiency not lower than that obtainable by means of a traditional leak detector; furthermore it does not introduce contamination risks after bakeout. (4 refs).

  17. Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak

    OpenAIRE

    Polymeropoulos, E. T.; Heldmaier, G; Frappell, P. B.; McAllan, B. M.; Withers, K. W.; M. Klingenspor; White, C.R.; Jastroch, M.

    2011-01-01

    Metabolic rates of mammals presumably increased during the evolution of endothermy, but molecular and cellular mechanisms underlying basal metabolic rate (BMR) are still not understood. It has been established that mitochondrial basal proton leak contributes significantly to BMR. Comparative studies among a diversity of eutherian mammals showed that BMR correlates with body mass and proton leak. Here, we studied BMR and mitochondrial basal proton leak in liver of various marsupial species. Su...

  18. Hanford Single-Shell Tank Leak Causes and Locations - 241-T Farm

    Energy Technology Data Exchange (ETDEWEB)

    Girardot, Crystal L.; Harlow, Donald G.

    2014-05-15

    This document identifies 241-T Tank Farm (T Farm) leak causes and locations for the 100 series leaking tanks (241-T-106 and 241-T-111) identified in RPP-RPT-55084, Rev. 0, Hanford 241-T Farm Leak Inventory Assessment Report. This document satisfies the T Farm portion of the target (T04) in the Hanford Federal Facility Agreement and Consent Order milestone M-045-91F.

  19. Hanford Single Shell Tank Leak Causes and Locations - 241-TX Farm

    Energy Technology Data Exchange (ETDEWEB)

    Girardot, C. L.; Harlow, D> G.

    2014-07-22

    This document identifies 241-TX Tank Farm (TX Farm) leak causes and locations for the 100 series leaking tanks (241-TX-107 and 241-TX-114) identified in RPP-RPT-50870, Rev. 0, Hanford 241-TX Farm Leak Inventory Assessment Report. This document satisfies the TX Farm portion of the target (T04) in the Hanford Federal Facility Agreement and Consent Order milestone M-045-91F.

  20. Hanford Single-Shell Tank Leak Causes and Locations - 241-C Farm

    Energy Technology Data Exchange (ETDEWEB)

    Girardot, Crystal L.; Harlow, Donald G.

    2013-07-30

    This document identifies 241-C Tank Farm (C Farm) leak causes and locations for the 100 series leaking tanks (241-C-101 and 241-C-105) identified in RPP-RPT-33418, Rev. 2, Hanford C-Farm Leak Inventory Assessments Report. This document satisfies the C Farm portion of the target (T04) in the Hanford Federal Facility Agreement and Consent Order milestone M-045-91F.

  1. Spontaneous cerebrospinal fluid leak following a pilates class: a case report

    OpenAIRE

    Davis, James; Yanny, Irini; Chatu, Sukhdev; Dubois, Patrick; Hayee, Bu; Moran, Nick

    2014-01-01

    Introduction A spinal cerebrospinal fluid leak is the most common cause of spontaneous intracranial hypotension which is an uncommon but increasingly recognized cause of headache. This article describes the first reported case of pilates being associated with a spontaneous spinal cerebrospinal fluid leak whilst also highlighting the key information about spontaneous cerebrospinal fluid leaks that will be useful to the general clinician. Case presentation We present the case of a 42-year-old C...

  2. Hanford Single-Shell Tank Leak Causes and Locations - 241-U Farm

    Energy Technology Data Exchange (ETDEWEB)

    Girardot, Crystal L.; Harlow, Donald G.

    2013-12-02

    This document identifies 241-U Tank Farm (U Farm) leak causes and locations for the 100 series leaking tanks (241-U-104, 241-U-110, and 241-U-112) identified in RPP-RPT-50097, Rev. 0, Hanford 241-U Farm Leak Inventory Assessment Report. This document satisfies the U-Farm portion of the target (T04) in the Hanford Federal Facility Agreement and Consent Order milestone M-045-91F.

  3. Hanford Single-Shell Tank Leak Causes and Locations - 241-A Farm

    Energy Technology Data Exchange (ETDEWEB)

    Girardot, Crystal L.; Harlow, Donald G.

    2013-09-10

    This document identifies 241-A Tank Farm (A Farm) leak causes and locations for the 100 series leaking tanks (241-A-104 and 241-A-105) identified in RPP-ENV-37956, Hanford A and AX Farm Leak Assessment Report. This document satisfies the A Farm portion of the target (T04) in the Hanford Federal Facility Agreement and Consent Order milestone M-045-91F.

  4. Incidence and Costs of Pinhole Leak Corrosion and Corporate Cost of Capital Borrowing

    OpenAIRE

    Kleczyk, Ewa Jadwiga

    2008-01-01

    The first part of this doctorate dissertation examines the factors influencing the occurrence and costs of pinhole leak corrosion as well as the household decisions for corrosion prevention and plumbing material selection. Three mail surveys of households were used to elicit the experiences with leaks as well as the optimal corrosion prevention and material choices. Probability modeling (i.e. MNL) and linear regression analysis were used to analyze survey responses. Pinhole leak occurrences...

  5. Specialists meeting on leak detection and location in LMFBR steam generators. Summary report

    International Nuclear Information System (INIS)

    The following topics covered at the meeting were: with leak detection and location methods and equipment, including concentration measurements, helium tests, and electromagnetic methods; acoustic leak detection and related equipment; techniques and experiences in ensuring and measuring steam generator tightness during manufacturing, installation and repair, tube inspection methods for periodic control and damage assessment following leaks, influence of these methods on design of steam generators for LMFBR type reactors

  6. Comprehensive Leakproof Measures for Pancreaticoduodenectomy:A Report of 128 Consecutive Operations Without Pancreatic Leak

    Institute of Scientific and Technical Information of China (English)

    LIHan-Xian

    2003-01-01

    MeSHpancreaticoduodenectomy;pancreatic anastomotic leak; fistula of pancreas;periampullary carcinoma; jaundice complicationcarcinoma of pancreas;ABSTRACY Object To prevent pancreatic anastomotic leak by the comprehensive leakproof measures for pancre-aticoduodenectomy. Methods From December 1981 to June 2002, 128 consecutive patients underwent pancreati-coduodenectomy. 127 cases suffered from the malignant disease and one from chronic pancreatitis. The author performedthe operations and adopted the comprehensive measures to prevent pancreatic anastomotic leak. The measures were mainly

  7. Cushing Syndrome

    Science.gov (United States)

    ... links Share this: Page Content What is Cushing’s syndrome? Cushing’s syndrome is a condition that occurs when the body’s ... medication or as a result of a tumor, Cushing’s syndrome can develop. Many factors influence whether this happens, ...

  8. Dumping Syndrome

    Science.gov (United States)

    ... Disease Organizations​​ (PDF, 341 KB)​​​​​ Alternate Language URL Dumping Syndrome Page Content On this page: What is ... Nutrition Points to Remember Clinical Trials What is dumping syndrome? Dumping syndrome occurs when food, especially sugar, ...

  9. Leak-before-break demonstration for a typical PWR main steam pipe

    International Nuclear Information System (INIS)

    Currently the main steam line break evaluations of pressurized water reactor coolant systems are performed for postulated circumferential (guillotine) breaks. This results in overly conservation loading conditions. The objective of this paper is to study the local and global stability of a postulated through wall circumferential flaw in the main steam pipe of a typical pressurized water reactor. Steam leak rates are estimated and are examined in light of currently available leak rate criteria to demonstrate the leak-before-break condition. The need for additional criteria for detection of steam leaks is identified

  10. Hanford Single-Shell Tank Leak Causes and Locations - 241-BY and 241-TY Farm

    Energy Technology Data Exchange (ETDEWEB)

    Girardot, Crystal L.; Harlow, Donald G.

    2013-11-19

    This document identifies 241-BY Tank Farm (BY Farm) and 241-TY Tank Farm (TY Farm) leak causes and locations for the 100 series leaking tanks (241-BY-103, 241-TY-103, 241-TY-104, 241-TY-105, and 241-TY-106) identified in RPP-RPT-43704, Hanford BY Farm Leak Assessments Report, and in RPP-RPT-42296, Hanford TY Farm Leak Assessments Report. This document satisfies the BY and TY Farm portion of the target (T04) in Hanford Federal Facility Agreement and Consent Order milestone M-045-91F.

  11. CT findings suggesting anastomotic leak and predicting the recovery period following gastric surgery

    International Nuclear Information System (INIS)

    To assess diagnostic performance of routine CT for detecting anastomotic leak after gastric surgery, and analyse the relationship between recovery period and CT findings. We included 179 patients who underwent immediate CT and fluoroscopy after gastric surgery. Two reviewers retrospectively rated the possibility of leak on CT using a five-point scale focused on predefined CT findings. They also evaluated CT findings. Patients were categorised as: Group I, leak on fluoroscopy; Group II, possible leak on CT but negative on fluoroscopy; Group III, no leak. We analysed the relationship between recovery period and group. Area under the curve for detecting leak on CT was 0.886 in R1 and 0.668 in R2 with moderate agreement (k = 0.482). Statistically common CT findings for leak included discontinuity, large amount of air-fluid and wall thickening at anastomosis site (p < 0.05). Discontinuity at anastomosis site and a large air-fluid collection were independently associated with leak (p < 0.05). The recovery period including hospitalisation and postoperative fasting period was longer in Group I than Group II or III (p < 0.05). Group II showed a longer recovery period than Group III (p < 0.05). Postoperative routine CT was useful for predicting anastomotic leak using specific findings, and for predicting length of recovery period. (orig.)

  12. Temperature monitoring and leak detection in sodium circuits of FBR using Raman distributed fiber optic sensor

    International Nuclear Information System (INIS)

    This paper discusses the fiber optic temperature sensor based leak detection in the coolant circuits of fast breeder reactor. These sensors measure the temperature based on spontaneous Raman scattering principle and is not influenced by the electromagnetic interference. Various experiments were conducted to evaluate the performance of the fiber optic sensor based leak detection using Raman distributed Temperature Sensor (RDTS). This paper also deals with the details of fiber optic sensor type leak detector layout for the coolant circuit of FBR, performance requirement of leak detection system, description of the test facility, experimental procedure and test results of various experiments conducted. (author)

  13. Development of a leak-before break procedure for pressurised components

    International Nuclear Information System (INIS)

    For pressurised components there is an increasing interest in the use of leak-before-break arguments to show that defects will behave in a ''failsafe'' manner by growing in such a way as to cause a detectable leak before a disruptive failure of the pressure boundary can occur. The CEGB operates a wide variety of plant and has recognised the need for a flexible leak-before-break procedure which can be applied in a variety of different situations including part-through defects. This paper describes the development of such a procedure and discusses some of the key aspects of the leak-before-break procedure. (author)

  14. CT findings suggesting anastomotic leak and predicting the recovery period following gastric surgery

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Ho; Kim, Jung Hoon; Shin, Cheong-Il; Kim, Se Hyung; Han, Joon Koo; Choi, Byung Ihn [Seoul National University College of Medicine, Department of Radiology, Institute of Radiation Medicine, Jongno-gu, Seoul (Korea, Republic of)

    2015-07-15

    To assess diagnostic performance of routine CT for detecting anastomotic leak after gastric surgery, and analyse the relationship between recovery period and CT findings. We included 179 patients who underwent immediate CT and fluoroscopy after gastric surgery. Two reviewers retrospectively rated the possibility of leak on CT using a five-point scale focused on predefined CT findings. They also evaluated CT findings. Patients were categorised as: Group I, leak on fluoroscopy; Group II, possible leak on CT but negative on fluoroscopy; Group III, no leak. We analysed the relationship between recovery period and group. Area under the curve for detecting leak on CT was 0.886 in R1 and 0.668 in R2 with moderate agreement (k = 0.482). Statistically common CT findings for leak included discontinuity, large amount of air-fluid and wall thickening at anastomosis site (p < 0.05). Discontinuity at anastomosis site and a large air-fluid collection were independently associated with leak (p < 0.05). The recovery period including hospitalisation and postoperative fasting period was longer in Group I than Group II or III (p < 0.05). Group II showed a longer recovery period than Group III (p < 0.05). Postoperative routine CT was useful for predicting anastomotic leak using specific findings, and for predicting length of recovery period. (orig.)

  15. Location and repair of air leaks in the ATF vacuum vessel

    International Nuclear Information System (INIS)

    On the basis of partial pressure rate-of-rise and base pressure measurements, it was determined that the Advanced Toroidal Facility (ATF) vacuum vessel had an air leak in the low 10-4 mbarx ell/s range. Pinpointing this leak by conventional helium leak-checking procedures was not possible, because large portions of the outside of the vessel are covered by the helical field coils and a structural shell. Various alternative leak detection schemes that were considered are summarized and their advantages and disadvantages noted. In the method ultimately employed, gum-rubber patches of various sizes ranging from 12.7 by 12.7 cm to 20.3 by 30.5 cm were positioned on the inside surfaces of the vessel and evacuated by the leak detector (LD). After roughly 5% of the surface was inspected in this way, a leak of >10-5 mbar xL/s was discovered and localized to an area of 5 by 5 cm. Dye penetrant applied to this area disclosed three pinholes. Two small slag pockets were discovered while these points were being ground out. After these were rewelded, no further leakage could be found in the repaired area. Global leak rates measured after the machine was reevacuated indicated that this leak was about 30% of the overall leak rate. 1 ref., 5 figs., 1 tab

  16. The application of capnography to differentiate peri-chest tube air leak from parenchymal leak following pulmonary surgery

    OpenAIRE

    Oparka, Jonathan D.; Walker, William S

    2014-01-01

    Prolonged air leak is a common complication of pulmonary resection. However, while a bubbling chest drain is commonly related to parenchymal air leakage, it may also be caused by air entering the pleural cavity via an incomplete seal of the tissues at the chest tube insertion site. Examination alone is not sufficient to guide the surgeon as to which of the above complications is responsible for drain bubbling. We describe a simple method, whereby a CO2 monitoring device is attached to the che...

  17. Capillary electrophoresis in tapered capillary manufactured by etching with sub-supercritical water

    Czech Academy of Sciences Publication Activity Database

    Karásek, Pavel; Horká, Marie; Šlais, Karel; Roth, Michal; Planeta, Josef

    Messina : Chromaleont S.r.L, 2012 - (Sandra, P.; Mondello, L.). s. 254 [International Symposium on Capillary Chromatography /36./ and GC x GC Symposium /9./. 27.5.2012-01.06.2012, Riva del Garda] R&D Projects: GA ČR(CZ) GAP206/11/0138; GA ČR(CZ) GAP106/12/0522; GA MV VG20112015021 Institutional research plan: CEZ:AV0Z40310501 Keywords : electrophoresis in tapered capillaries * supercritical water * complex samples Subject RIV: CB - Analytical Chemistry, Separation

  18. Leaked fuel detection device for nuclear power plant

    International Nuclear Information System (INIS)

    The present invention provides an inexpensive fuel leak detection device at a good detection sensitivity and of a simple structure. Specifically, the device of the present invention comprises (1) a sampling means for sampling water from a nuclear fuel mast tube, (2) a gas separation means for introducing sampled water to a separation chamber, jetting and stirring it in the separation chamber to separate gases, (3) a gas recycling means for delivering the gases in the separation chamber and returning them again, and (4) a measuring means for measuring radiation dose of the gases circulated by the gas circulation means. Since the device thus constituted has a simple gas separation means, the structure of the nuclear fuel mast tube is not complicated. Since the gas is recycled, the volume for the gas portion is reduced, so that the amount of the fission products per a predetermined volume is increased and the sensitivity for the leaked fuel detection is increased. Since the structure is simple, the cost can be reduced. (I.S.)

  19. Soil oxidation of methane influenced by natural gas leaks

    International Nuclear Information System (INIS)

    Methane leaking from buried natural gas distribution and transmission systems can be oxidized at least in part by the soil microbial community (mainly by methanotrophs). Two sites near Washington State University (Pullman, WA) have been used since summer 1992 to determine the potential of subsurface microbes to oxizide methane over a wide range of simulated leak rates and to determine the influence of soil parameters on oxidation rates. Sulfur hexafluoride (SF6) tracer is being used to quantify the subsurface diffusion associated with gas leakage. Our preliminary flux measurement results indicate that at low leakage rates (1 ml/min.) and under favorable environmental conditions about 80 to 90% of methane can be oxidized. Rates of methane consumption are strongly dependent on soil temperature and moisture content. The results also indicate that methane oxidation is accompanied by oxygen consumption and production of carbon dioxide. Soil gas samples from subsurface layers indicate that methane oxidation is predominant in the top 6 to 12 inches of subsurface horizon. During the winter period when the ground was frozen oxidation rates declined dramatically

  20. Corrosion Evaluation of Tank 40 Leak Detection Box

    Energy Technology Data Exchange (ETDEWEB)

    Mickalonis, J.I.

    1999-07-29

    'Leak detection from the transfer lines in the tank farm has been a concern for many years because of the need to minimize exposure of personnel and contamination of the environment. The leak detection box (LDB) is one line of defense, which must be maintained to meet this objective. The evaluation of a failed LDB was one item from an action plan aimed at minimizing the degradation of LDBs. The Tank 40 LDB, which failed in service, was dug up and shipped to SRTC for evaluation. During a video inspection while in service, this LDB was found to have black tubercles on the interior, which suggested possible microbial involvement. The failure point, however, was believed to have occurred in the drain line from the transfer line jacket. Visual, metallurgical, and biological analyses were performed on the LDB. The analysis results showed that there was not any adverse microbiological growth or significant localized corrosion. The corrosion of the LDB was caused by exposure to aqueous environments and was typical of carbon steel pipes in soil environments.'

  1. Non-linear leak currents affect mammalian neuron physiology

    Directory of Open Access Journals (Sweden)

    Shiwei Huang

    2015-11-01

    Full Text Available In their seminal works on squid giant axons, Hodgkin and Huxley approximated the membrane leak current as Ohmic, i.e. linear, since in their preparation, sub-threshold current rectification due to the influence of ionic concentration is negligible. Most studies on mammalian neurons have made the same, largely untested, assumption. Here we show that the membrane time constant and input resistance of mammalian neurons (when other major voltage-sensitive and ligand-gated ionic currents are discounted varies non-linearly with membrane voltage, following the prediction of a Goldman-Hodgkin-Katz-based passive membrane model. The model predicts that under such conditions, the time constant/input resistance-voltage relationship will linearize if the concentration differences across the cell membrane are reduced. These properties were observed in patch-clamp recordings of cerebellar Purkinje neurons (in the presence of pharmacological blockers of other background ionic currents and were more prominent in the sub-threshold region of the membrane potential. Model simulations showed that the non-linear leak affects voltage-clamp recordings and reduces temporal summation of excitatory synaptic input. Together, our results demonstrate the importance of trans-membrane ionic concentration in defining the functional properties of the passive membrane in mammalian neurons as well as other excitable cells.

  2. An axial approach to detection in capillary electrophoresis

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, J.A.

    1993-05-01

    Our approach involves on-axis illumination of the compounds inside the capillary detection region and is applied to absorbance and fluorescence detection. Absorbance measurements were made by focussing an incident laser beam into one capillary end; by using signals collected over the entire length of analyte band, this enhances the analytical path length of conventional absorbance detection 60x. This instrument offers a 15x improvement in detection limits. Three fluorescence detection experiments are discussed, all of which involve insertion of an optical fiber into capillary. The first uses a high refractive index liquid phase to obtain total internal reflectance along capillary axis, this reducing light scatter. The second uses a charge-coupled device camera for simultaneous imaging of a capillary array (this may be useful in genome sequencing, etc.). The third is a study of fluid motion inside the capillary under pressure-driven and electroosmotic flow. The thesis is divided into four parts. Figs, tabs.

  3. Pathobiology of acute respiratory distress syndrome.

    Science.gov (United States)

    Sapru, Anil; Flori, Heidi; Quasney, Michael W; Dahmer, Mary K

    2015-06-01

    The unique characteristics of pulmonary circulation and alveolar-epithelial capillary-endothelial barrier allow for maintenance of the air-filled, fluid-free status of the alveoli essential for facilitating gas exchange, maintaining alveolar stability, and defending the lung against inhaled pathogens. The hallmark of pathophysiology in acute respiratory distress syndrome is the loss of the alveolar capillary permeability barrier and the presence of protein-rich edema fluid in the alveoli. This alteration in permeability and accumulation of fluid in the alveoli accompanies damage to the lung epithelium and vascular endothelium along with dysregulated inflammation and inappropriate activity of leukocytes and platelets. In addition, there is uncontrolled activation of coagulation along with suppression of fibrinolysis and loss of surfactant. These pathophysiological changes result in the clinical manifestations of acute respiratory distress syndrome, which include hypoxemia, radiographic opacities, decreased functional residual capacity, increased physiologic deadspace, and decreased lung compliance. Resolution of acute respiratory distress syndrome involves the migration of cells to the site of injury and re-establishment of the epithelium and endothelium with or without the development of fibrosis. Most of the data related to acute respiratory distress syndrome, however, originate from studies in adults or in mature animals with very few studies performed in children or juvenile animals. The lack of studies in children is particularly problematic because the lungs and immune system are still developing during childhood and consequently the pathophysiology of pediatric acute respiratory distress syndrome may differ in significant ways from that seen in acute respiratory distress syndrome in adults. This article describes what is known of the pathophysiologic processes of pediatric acute respiratory distress syndrome as we know it today while also presenting the much

  4. Capillary remodeling in bleomycin-induced pulmonary fibrosis.

    OpenAIRE

    Schraufnagel, D. E.; Mehta, D.; Harshbarger, R.; Treviranus, K.; Wang, N. S.

    1986-01-01

    Lung fibrosis is a process in which collagen is laid down and the delicate capillary-alveolar relationship is disturbed. The architectural changes which occur in the capillaries, a main element of the oxygen transferring unit, are difficult to illustrate without a three-dimensional tool, such as scanning electron microscopy. Therefore, a scanning electron microscopic study was undertaken to show the capillary changes of lung fibrosis. Fibrosis was induced in rats by intratracheal instillation...

  5. Nicked-sleeve interface for two-dimensional capillary electrophoresis

    OpenAIRE

    Flaherty, Ryan J.; Huge, Bonnie J.; Bruce, Spencer M.; Dada, Oluwatosin O.; Dovichi, Norman J.

    2013-01-01

    We report an improved interface for two-dimensional capillary electrophoresis. This interface is based on capillary tubing and a Plexiglas chip, both of which were milled using a micro-dicing saw. The interface was evaluated and compared to a traditional interface design for both pseudo one-dimensional and two-dimensional capillary electrophoresis. We observe less than 70% transfer efficiency for the traditional design and greater than 90% transfer efficiency with this new interface.

  6. Modified monolithic silica capillary for preconcentration of catecholamines

    Institute of Scientific and Technical Information of China (English)

    Wei Chang; Tusyo-shi Komazu

    2009-01-01

    Preconcentration of catecholamines by the modified monolithic silica in the capillary was investigated in this study. In order to achieve a microchip-based method for determining catecholamines in the saliva, the monolithic silica was fabricated in the capillary and the monolithic silica was chemically modified by on-column reaction with phenylboronate. Different modified methods were compared. The concentration conditions were optimized. This study indicates the applicability of the modified monolithic silica capillary when it was used to concentrate catecholamines.

  7. Functional capillary rarefaction in mild blood pressure elevation

    OpenAIRE

    Cheng, Cynthia; Diamond, James J.; Falkner, Bonita

    2008-01-01

    Capillary rarefaction is described in patients with moderate to severe hypertension. The study objective was to determine if structural and/or functional capillary rarefaction is detectable and associated with endothelial dysfunction in patients with mild blood pressure elevation (HBP: Systolic blood pressure 130 – 160 mm Hg). Capillary density was quantified by direct capillaroscopy in 110 nondiabetic black and non-black subjects. Endothelial function was quantified by plethysmographic measu...

  8. Interaction of Treponema pallidum with isolated rabbit capillary tissues.

    OpenAIRE

    Quist, E E; Repesh, L A; Zeleznikar, R; Fitzgerald, T J

    1983-01-01

    Within infected tissue Treponema pallidum shows a characteristic predilection for perivascular areas. After intact capillaries had been prepared from rabbit brain tissue treponemes were incubated with isolated capillaries and visualised by darkfield, phase contrast, and scanning electron microscopy. The organisms rapidly attached to the surface of the capillaries at the tip of the treponeme; attached organisms retained motility for longer periods than unattached organisms. Treponema pertenue ...

  9. Capillary Micro-Flow Through a Fiber Bundle(Ⅰ)

    Institute of Scientific and Technical Information of China (English)

    ZHU Ying-dan; WANG Ji-hui; TAN Hua; GAO Guo-qiang

    2004-01-01

    The present work considered the capillary micro-flow through a fiber bundle. The resin heights in the fiber bundle as a function of time were used to determine the experimental values of capillary pressure and the permeability by the nonlinear regression fitting method. The fitting curves showed a good agreement with experiments. However, these values of capillary pressure from short- time experiments were much lower than the theoretical results from the Yang-Laplace Equation. More accurate capillary pressure was predicted from the presented long-run experiment.

  10. High Performance Wafer-Based Capillary Electrochromatography Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Phase II research comprises designing, constructing, and testing a chip-based capillary electrochromatography (CEC) prototype for separation and analysis of...

  11. Creeping motion of long bubbles and drops in capillary tubes

    DEFF Research Database (Denmark)

    Westborg, Henrik; Hassager, Ole

    1989-01-01

    The flow of inviscid bubbles and viscous drops in capillary tubes has been simulated by a Galerkin finite element method with surface tension included at the bubble/liquid interface. The results show good agreement with published experimental results. At low capillary numbers the front and the rear...... disappear at high capillary numbers. Furthermore the flow of a viscous drop through a doughnut shaped constriction in a capillary tube has been simulated. The simulations show that snap-off may be initiated by a sudden drop in the flow rate after the drops have protruded for some distance beyond the throat...

  12. Novel Micro-Capillary Electrochromatography for Mars Organic Detector Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Los Gatos Research proposes to develop a powerful new technology - next generation Micro-Capillary Electrochromatography - a high performance and low power...

  13. Novel Micro-Capillary Electrochromatography for Mars Organic Detector Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Los Gatos Research proposes to develop a powerful new technology - next generation Micro-Capillary Electrochromatography ? a high performance and low power...

  14. Capillary pericytes regulate cerebral blood flow in health and disease

    DEFF Research Database (Denmark)

    Hall, Catherine N; Reynell, Clare; Gesslein, Bodil;

    2014-01-01

    that neuronal activity and the neurotransmitter glutamate evoke the release of messengers that dilate capillaries by actively relaxing pericytes. Dilation is mediated by prostaglandin E2, but requires nitric oxide release to suppress vasoconstricting 20-HETE synthesis. In vivo, when sensory input...... increases blood flow, capillaries dilate before arterioles and are estimated to produce 84% of the blood flow increase. In pathology, ischaemia evokes capillary constriction by pericytes. We show that this is followed by pericyte death in rigor, which may irreversibly constrict capillaries and damage the...

  15. Modelization and simulation of capillary barriers

    International Nuclear Information System (INIS)

    Among the different underground transport phenomena, that due to water flows is of great relevance. Water flows in infiltration and percolation processes are responsible of the transport of hazardous wastes towards phreatic layers. From the industrial and geological standpoints, there is a great interest in the design of natural devices to avoid the flows transporting polluting substances. This interest is increased when devices are used to isolate radioactive waste repositories, whose life is to be longer than several hundred years. The so-called natural devices are those based on the superimposition of material with different hydraulic properties. In particular, the flow retention in this kind stratified media, in unsaturated conditions, is basically due to the capillary barrier effect, resulting from placing a low conductivity material over another with a high hydraulic conductivity. Covers designed from the effect above have also to allow a drainage of the upper layer. The lower cost of these covers, with respect to other kinds of protection systems, and the stability in time of their components make them very attractive. However, a previous investigation to determine their effectivity is required. In this report we present the computer code BCSIM, useful for easy simulations of unsaturated flows in a capillary barrier configuration with drainage, and which is intended to serve as a tool for designing efficient covers. The model, the numerical algorithm and several implementation aspects are described. Results obtained in several simulations, confirming the effectivity of capillary barriers as a technique to build safety covers for hazardous waste repositories, are presented. (Author)

  16. Capacitively coupled contactless conductivity detection and sequential injection analysis in capillary electrophoresis and capillary electro-chromatography

    OpenAIRE

    Mai, Thanh Duc

    2011-01-01

    This thesis focuses on the applications of capacitively coupled contactless conductivity detection (C4D) in capillary electrophoresis (CE) hybridized with high-performance liquid chromatography (HPLC), i.e. in capillary electrochromatography and pressure-assisted capillary electrophoresis, as well as on the development and applications of an extension of CE-C4D with sequential injection analysis (SIA). At first, the in-house built C4D was used for electro-chromatographic determinations of...

  17. Determination of glycyrrhizin in liqueurs by on-line coupled capillary isotachophoresis with capillary zone electrophoresis.

    Science.gov (United States)

    Kvasnicka, Frantisek; Voldrich, Michal; Vyhnálek, Josef

    2007-10-26

    An on-line coupled capillary isotachophoresis-capillary zone electrophoresis method for the determination of glycyrrhizin in liqueurs is described. The optimised electrolyte system was 5 mM HCl+11 mM epsilon-aminocaproic acid+0.05% hydroxyethylcellulose+30% methanol (leading electrolyte), 5 mM caproic acid+30% methanol (terminating electrolyte) and 20 mM caproic acid+10 mM histidine+0.1% hydroxyethylcellulose+30% methanol (background electrolyte). Method characteristics, i.e., linearity (20-500 ng/ml), accuracy (recovery 99+/-4%), intra-assay repeatability (2%), intermediate repeatability (3.8%) and detection limit (8 ng/ml) were determined. Speed of analysis, low laboriousness, high sensitivity and low-running cost are the typical attributes of the capillary isotachophoresis-capillary zone electrophoresis method. Developed method was successfully applied to analysis of liqueurs with liquorice extract and some foods (sweets and food supplements) containing liquorice. Found levels of glycyrrhizin in liqueurs, sweets and food supplements varied between 1-16 mg/l, 850-1050 mg/kg and 1.6-1.8 g/kg, respectively. PMID:17875310

  18. Capillary zone electrophoresis and packed capillary column liquid chromatographic analysis of recombinant human interleukin-4.

    Science.gov (United States)

    Bullock, J

    1993-02-24

    Capillary zone electrophoresis (CZE) and packed capillary column liquid chromatography (micro-LC) have been applied to the analysis of the recombinant human protein interleukin-4 (rhIL-4). Separations for both the parent protein and its enzymatic digest were developed for the purpose of characterizing protein purity and identity. CZE separations of the intact protein were investigated over the pH range of 4.5 to 8.0 using uncoated fused silica capillaries. Gradient reversed-phase micro-LC was performed using 0.32 mm packed capillary columns at flow-rates of 5-6 microliters/min. Emphasis was placed on the ability of these methods to separate close structural variants and degradation products of the protein. Peptide mapping of the tryptic digest of rhIL-4 using a combination of CZE and micro-LC provided complimentary high resolution methods for establishing protein identity. Reproducible separations were achieved using sub-picomol amounts of sample. The advantages and problems encountered with these two techniques for characterizing rhIL-4 were assessed. PMID:8450025

  19. Electroviscous effects in capillary filling of nanochannels

    DEFF Research Database (Denmark)

    Mortensen, Asger; Kristensen, Anders

    2008-01-01

    maximum in the mesoscopic regime where the channel height (or more generally the hydraulic radius) is comparable to the screening length. However, for realistic estimates of central parameters, we find that the electroviscous contribution to the apparent viscosity is at most a 1% effect.......We theoretically examine the widespread hypothesis of an electroviscous origin of the increase in apparent viscosity observed in recent experiments on capillary filling of nanochannels. Including Debye-layer corrections to the hydraulic resistance, we find that the apparent viscosity reaches a...

  20. Gas-Filled-Capillary Discharge Experiment

    Czech Academy of Sciences Publication Activity Database

    Schmidt, Jiří; Koláček, Karel; Frolov, Oleksandr; Prukner, Václav; Štraus, Jaroslav; Sobota, Jaroslav; Fořt, Tomáš

    Washington, DC: IEEE, 2010, s. 707-709. (IEEE Xplore). ISBN 978-1-4244-4064-1. [IEEE International Pulsed Power Conference/17th./. Washington, D.C. (US), 28.06.2010-02.07.2010] R&D Projects: GA MŠk(CZ) LC528; GA MŠk LA08024; GA AV ČR KJB100430702; GA AV ČR KAN300100702 Institutional research plan: CEZ:AV0Z20430508; CEZ:AV0Z20650511 Keywords : Capillary discharge * x-ray * laser Subject RIV: BL - Plasma and Gas Discharge Physics http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=5386405

  1. XUV Radiation Emitted by Capillary Pinching Discharge

    Czech Academy of Sciences Publication Activity Database

    Vrbová, M.; Jančárek, A.; Vrba, Pavel; Nevrkla, M.; Kolař, P.

    Vol. 136. Dordrecht: Springer Proceedings in Physics , 2010 - (Lee, J.; Nam, C.; Janulewicz, K.), s. 257-262. (Springer Proceedings in Physics . 136). ISBN 978-94-007-1185-3. ISSN 0930-8989. [International Conference on X-Ray Laser s 2010/12th./. Gwangju (KR), 30.05.2010-04.06.2010] R&D Projects: GA MŠk LA08024 Institutional research plan: CEZ:AV0Z20430508 Keywords : Capillary Z-pinch * water window radiation source * RHMD Z engine Subject RIV: BH - Optics, Masers, Laser s http://www.springer.com/series/361

  2. Analysis of antimicrobial peptides by capillary electrophoresis

    Czech Academy of Sciences Publication Activity Database

    Ehala, Sille; Niederhafner, Petr; Čeřovský, Václav; Řezanka, P.; Sýkora, D.; Král, V.; Kašička, Václav

    Praha : Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2011 - (Slaninová, J.), s. 37-40 ISBN 978-80-86241-44-9. - (Collection Symposium Series. 13). [Biologically Active Peptides /12./. Praha (CZ), 27.04.2011-29.04.2011] R&D Projects: GA ČR(CZ) GA203/09/0675; GA ČR(CZ) GA203/08/1428 Institutional research plan: CEZ:AV0Z40550506 Keywords : capillary electrophoresis * antimicrobial peptides * gold nanoparticles Subject RIV: CC - Organic Chemistry

  3. High sensitivity radiation detector for capillary electrophoresis

    International Nuclear Information System (INIS)

    Capillary electrophoresis is an important new instrumental technique capable of high resolution separation and analysis of small quantities of nucleotides, amino acids, peptides, and proteins with very high efficiency and throughput. The unprecedented sensitivity of this technique will be useful for such new applications as in vivo labeling and identification of trace substances and single cell work. The principle limitation of this technique for radiolabeled molecules has been identified as the sensitivity of the detector, primarily due to the small sample volume (32P-labeled biomolecules with unprecedented sensitivity. This detector can be easily retrofitted into existing CE apparatus

  4. Study of antimicrobial peptides by capillary electrophoresis

    Czech Academy of Sciences Publication Activity Database

    Tůmová, Tereza; Monincová, Lenka; Čeřovský, Václav; Kašička, Václav

    Sofia: Bulgarian Peptide Society, 2015 - (Naydenova, E.; Pajpanova, T.; Danalev, D.), s. 304-305 ISBN 978-619-90427-2-4. [Peptides 2014. European Peptide Symposium /33./. Sofia (BG), 31.08.2014-05.09.2014] R&D Projects: GA ČR(CZ) GAP206/12/0453; GA ČR(CZ) GA13-17224S Institutional support: RVO:61388963 Keywords : peptides * antimicrobial activity * capillary electrophoresis Subject RIV: CB - Analytical Chemistry, Separation http://bulpepsoc.info/wp-content/uploads/2015/06/PEPTIDES-2014-electronic-version.pdf

  5. Gas-Filled-Capillary Discharge Experiment

    Czech Academy of Sciences Publication Activity Database

    Schmidt, Jiří; Koláček, Karel; Frolov, Oleksandr; Prukner, Václav; Štraus, Jaroslav

    Vol. IEEE Catalog Number: CFP09PPC. Piscataway : Institute of Electrical and Electronics Engineers, Inc, 2009. s. 245-245. ISBN 978-1-4244-4065-8. [IEEE International Pulsed Power Conference/17th./. 28.06.2009-02.07.2009, Washington, D.C.] R&D Projects: GA MŠk LA08024; GA AV ČR KJB100430702; GA AV ČR KAN300100702; GA MŠk(CZ) LC528 Institutional research plan: CEZ:AV0Z20430508 Keywords : Capillary discharge * x-ray * laser Subject RIV: BL - Plasma and Gas Discharge Physics http://ppc.missouri.edu/Abstracts.pdf

  6. Capillary Network, Cancer and Kleiber Law

    CERN Document Server

    Dattoli, G; Licciardi, S; Guiot, C; Deisboeck, T S

    2014-01-01

    We develop a heuristic model embedding Kleiber and Murray laws to describe mass growth, metastasis and vascularization in cancer. We analyze the relevant dynamics using different evolution equations (Verhulst, Gompertz and others). Their extension to reaction diffusion equation of the Fisher type is then used to describe the relevant metastatic spreading in space. Regarding this last point, we suggest that cancer diffusion may be regulated by Levy flights mechanisms and discuss the possibility that the associated reaction diffusion equations are of the fractional type, with the fractional coefficient being determined by the fractal nature of the capillary evolution.

  7. Air pollutant penetration through airflow leaks into buildings

    Energy Technology Data Exchange (ETDEWEB)

    Liu, De-Ling

    2002-09-01

    The penetration of ambient air pollutants into the indoor environment is of concern owing to several factors: (1) epidemiological studies have shown a strong association between ambient fine particulate pollution and elevated risk of human mortality; (2) people spend most of their time in indoor environments; and (3) most information about air pollutant concentration is only available from ambient routine monitoring networks. A good understanding of ambient air pollutant transport from source to receptor requires knowledge about pollutant penetration across building envelopes. Therefore, it is essential to gain insight into particle penetration in infiltrating air and the factors that affect it in order to assess human exposure more accurately, and to further prevent adverse human health effects from ambient particulate pollution. In this dissertation, the understanding of air pollutant infiltration across leaks in the building envelope was advanced by performing modeling predictions as well as experimental investigations. The modeling analyses quantified the extent of airborne particle and reactive gas (e.g., ozone) penetration through building cracks and wall cavities using engineering analysis that incorporates existing information on building leakage characteristics, knowledge of pollutant transport processes, as well as pollutant-surface interactions. Particle penetration is primarily governed by particle diameter and by the smallest dimension of the building cracks. Particles of 0.1-1 {micro}m are predicted to have the highest penetration efficiency, nearly unity for crack heights of 0.25 mm or higher, assuming a pressure differential of 4 Pa or greater and a flow path length of 3 cm or less. Supermicron and ultrafine particles (less than 0.1 {micro}m) are readily deposited on crack surfaces by means of gravitational settling and Brownian diffusion, respectively. The fraction of ozone penetration through building leaks could vary widely, depending

  8. Bacterial surface layer proteins as a novel capillary coating material for capillary electrophoretic separations.

    Science.gov (United States)

    Moreno-Gordaliza, Estefanía; Stigter, Edwin C A; Lindenburg, Petrus W; Hankemeier, Thomas

    2016-06-01

    A novel concept for stable coating in capillary electrophoresis, based on recrystallization of surface layer proteins on hydrophobized fused silica capillaries, was demonstrated. Surface layer protein A (SlpA) from Lactobacillus acidophilus bacteria was extracted, purified and used for coating pre-silanized glass substrates presenting different surface wettabilities (either hydrophobic or hydrophilic). Contact angle determination on SlpA-coated hydrophobic silica slides showed that the surfaces turned to hydrophilic after coating (53 ± 5°), due to a protein monolayer formation by protein-surface hydrophobic interactions. Visualization by atomic force microscopy demonstrated the presence of a SlpA layer on methylated silica slides displaying a surface roughness of 0.44 ± 0.02 nm. Additionally, a protein layer was visualized by fluorescence microscopy in methylated silica capillaries coated with SlpA and fluorescein isothiocyanate-labeled. The SlpA-coating showed an outstanding stability, even after treatment with 20 mM NaOH (pH 12.3). The electroosmotic flow in coated capillaries showed a partial suppression at pH 7.50 (3.8 ± 0.5 10(-9) m(2) V(-1) s(-1)) when compared with unmodified fused silica (5.9 ± 0.1 10(-8) m(2) V(-1) s(-1)). To demonstrate the potential of this novel coating, the SlpA-coated capillaries were applied for the first time for electrophoretic separation, and proved to be very suitable for the isotachophoretic separation of lipoproteins in human serum. The separations showed a high degree of repeatability (absolute migration times with 1.1-1.8% coefficient-of-variation (CV) within a day) and 2-3% CV inter-capillary reproducibility. The capillaries were stable for more than 100 runs at pH 9.40, and showed to be an exceptional alternative for challenging electrophoretic separations at long-term use. PMID:27155306

  9. Ehlers-Danlos syndrome(s) mimicking child abuse: Is there an impact on clinical practice?

    Science.gov (United States)

    Castori, Marco

    2015-12-01

    Ehlers-Danlos syndrome is a heterogeneous group of heritable connective tissue disorders characterized by increased fragility of various non-ossified tissues. It is usually ascertained due to abnormal skin texture, scarring complications, vascular fragility, or chronic symptoms, such as fatigue and musculoskeletal pain. Sometimes, Ehlers-Danlos syndrome remains undetected until the patient, usually in the pediatric age, shows extensive or severe mucocutaneous injuries after only minor traumas. In this scenario, the misdiagnosis of Ehlers-Danlos syndrome with child abuse is a possibility, as occasionally reported in the literature. Recently, more attention was posed by lay people between the possible association of Ehlers-Danlos syndrome and bone fragility. Literature and personal experience show a strong association between Ehlers-Danlos syndrome, generalized joint hypermobility and reduced bone mass density in older children and adults, especially fertile women. The existence of a true increased risk of fracture in Ehlers-Danlos syndrome is still a matter of debate in children and adults with little and conflicting evidence. In case of suspected child abuse, Ehlers-Danlos syndrome is certainly on the differential for bruising, especially in EDS types with marked cutaneous and capillary involvement. In suspected child abuse cases, careful examination of the index case and her/his extended family is routine, as well as exclusion of other disorders such as osteogenesis imperfecta. The hypothesis of Ehlers-Danlos syndrome as an alternative explanation for infantile fractures remains speculative. PMID:26452443

  10. Nailfold video capillaroscopy in Turner syndrome: a descriptive study Videocapilaroscopia na síndrome de Turner: estudo descritivo

    OpenAIRE

    Simone C. S. Coelho; Andressa D. Ramos; Virgínia S. Pinheiro; Paulo F. C. Solberg; Janaina P. de Faria; Erika C. O. Naliato; Therezinha J. Fernandes; Guimarães, Marília M

    2007-01-01

    BACKGROUND: An increased prevalence of impaired glucose homeostasis is reported in Turner syndrome. Endothelial changes are described in patients with insulin resistance, which may be present in patients with Turner syndrome. Video capillaroscopy is a noninvasive examination that allows assessment of vascular patency. OBJECTIVE: To describe the nailfold morphology of capillaries in Turner syndrome using video capillaroscopy. METHODS: Subjects were studied in a temperature-controlled room, 20 ...

  11. Kinetics of the valinomycin-induced potassium ion leak from liposomes with potassium thiocyanate enclosed

    NARCIS (Netherlands)

    Blok, M.C.; Gier, J. de; Deenen, L.L.M. van

    1974-01-01

    The kinetics of the valinomycin-induced K+ leak from egg lecithin liposomes with KCNS enclosed were studied by measuring the initial increase of the leak following the addition of the ionophore. Variation of liposome and valinomycin concentrations enabled a discrimination between the affinity of the

  12. Intermediate-Scale Laboratory Experiments of Subsurface Flow and Transport Resulting from Tank Leaks

    Energy Technology Data Exchange (ETDEWEB)

    Oostrom, Martinus; Wietsma, Thomas W.

    2014-09-30

    Washington River Protection Solutions contracted with Pacific Northwest National Laboratory to conduct laboratory experiments and supporting numerical simulations to improve the understanding of water flow and contaminant transport in the subsurface between waste tanks and ancillary facilities at Waste Management Area C. The work scope included two separate sets of experiments: •Small flow cell experiments to investigate the occurrence of potential unstable fingering resulting from leaks and the limitations of the STOMP (Subsurface Transport Over Multiple Phases) simulator to predict flow patterns and solute transport behavior under these conditions. Unstable infiltration may, under certain conditions, create vertically elongated fingers potentially transporting contaminants rapidly through the unsaturated zone to groundwater. The types of leak that may create deeply penetrating fingers include slow release, long duration leaks in relatively permeable porous media. Such leaks may have occurred below waste tanks at the Hanford Site. •Large flow experiments to investigate the behavior of two types of tank leaks in a simple layered system mimicking the Waste Management Area C. The investigated leaks include a relatively large leak with a short duration from a tank and a long duration leak with a relatively small leakage rate from a cascade line.

  13. 40 CFR 63.986 - Nonflare control devices used for equipment leaks only.

    Science.gov (United States)

    2010-07-01

    ... equipment leaks only. 63.986 Section 63.986 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... leaks only. (a) Equipment and operating requirements. (1) Owners or operators using a nonflare control... test is not required for any nonflare control device used only to control emissions from...

  14. A Multimodal Approach in Coil Embolization of a Bile Leak Following Cholecystectomy

    International Nuclear Information System (INIS)

    Bile leak is a well-known complication of cholecystectomy. Endoscopic drainage and decompression of the biliary system including temporary insertion of a biliary stent is generally considered the treatment of choice. We report the successful obliteration of a bile leak using fibered platinum coils placed under fluoroscopic guidance after stent treatment had failed

  15. Development of a vacuum leak test method for large-scale superconducting magnet test facilities

    International Nuclear Information System (INIS)

    Japan Atomic Energy Agency (JAEA) has developed leak detection technology for liquid helium temperature experiments in large-scale superconducting magnet test facilities. In JAEA, a cryosorption pump that uses an absorbent cooled by liquid nitrogen with a conventional helium leak detector, is used to detect helium gas that is leaking from pressurized welded joints of pipes and valves in a vacuum chamber. The cryosorption pump plays the role of decreasing aerial components, such as water, nitrogen and oxygen, to increase the sensitivity of helium leak detection. The established detection sensitivity for helium leak testing is 10-10 to 10-9 Pam3/s. A total of 850 welded and mechanical joints inside the cryogenic test facility for the ITER Central Solenoid Model Coil (CSMC) experiments have been tested. In the test facility, 73 units of glass fiber-reinforced plastic (GFRP) insulation break are used. The amount of helium permeation through the GFRP was recorded during helium leak testing. To distinguish helium leaks from insulation-break permeation, the helium permeation characteristic of the GFRP part was measured as a function of the time of helium charging. Helium permeation was absorbed at 6 h after helium charging, and the detected permeation is around 10-7 Pam3/s. Using the helium leak test method developed, CSMC experiments have been successfully completed. (author)

  16. Space Shuttle Main Engine Propellant Path Leak Detection Using Sequential Image Processing

    Science.gov (United States)

    Smith, L. Montgomery; Malone, Jo Anne; Crawford, Roger A.

    1995-01-01

    Initial research in this study using theoretical radiation transport models established that the occurrence of a leak is accompanies by a sudden but sustained change in intensity in a given region of an image. In this phase, temporal processing of video images on a frame-by-frame basis was used to detect leaks within a given field of view. The leak detection algorithm developed in this study consists of a digital highpass filter cascaded with a moving average filter. The absolute value of the resulting discrete sequence is then taken and compared to a threshold value to produce the binary leak/no leak decision at each point in the image. Alternatively, averaging over the full frame of the output image produces a single time-varying mean value estimate that is indicative of the intensity and extent of a leak. Laboratory experiments were conducted in which artificially created leaks on a simulated SSME background were produced and recorded from a visible wavelength video camera. This data was processed frame-by-frame over the time interval of interest using an image processor implementation of the leak detection algorithm. In addition, a 20 second video sequence of an actual SSME failure was analyzed using this technique. The resulting output image sequences and plots of the full frame mean value versus time verify the effectiveness of the system.

  17. Acoustic leak detection at complicated geometrical structures using fuzzy logic and neural networks

    International Nuclear Information System (INIS)

    An acoustic method based on pattern recognition is being developed. During the learning phase, the localization classifier is trained with sound patterns that are generated with simulated leaks at all locations endangered by leak. The patterns are extracted from the signals of an appropriate sensor array. After training unknown leak positions can be recognized through comparison with the training patterns. The experimental part is performed at an acoustic 1:3 model of the reactor vessel and head and at an original VVER-440 reactor in the former NPP Greifswald. The leaks were simulated at the vessel head using mobile sound sources driven either by compressed air, a piezoelectric transmitter or by a thin metal blade excited through a jet of compressed air. The sound patterns of the simulated leaks are simultaneously detected with an AE-sensor array and with high frequency microphones measuring structure-borne sound and airborne sound, respectively. Pattern classifiers based on Fuzzy Pattern Classification (FPC) and Artificial Neural Networks (ANN) are currently tested for validation of the acoustic emission-sensor array (FPC), leak localization via structure-borne sound (FPC) and the leak localization using microphones (ANN). The initial results show the used classifiers principally to be capable of detecting and locating leaks, but they also show that further investigations are necessary to develop a reliable method applicable at NPPs. (orig./HP)

  18. Helium Mass Spectrometer Leak Detection: A Method to Quantify Total Measurement Uncertainty

    Science.gov (United States)

    Mather, Janice L.; Taylor, Shawn C.

    2015-01-01

    In applications where leak rates of components or systems are evaluated against a leak rate requirement, the uncertainty of the measured leak rate must be included in the reported result. However, in the helium mass spectrometer leak detection method, the sensitivity, or resolution, of the instrument is often the only component of the total measurement uncertainty noted when reporting results. To address this shortfall, a measurement uncertainty analysis method was developed that includes the leak detector unit's resolution, repeatability, hysteresis, and drift, along with the uncertainty associated with the calibration standard. In a step-wise process, the method identifies the bias and precision components of the calibration standard, the measurement correction factor (K-factor), and the leak detector unit. Together these individual contributions to error are combined and the total measurement uncertainty is determined using the root-sum-square method. It was found that the precision component contributes more to the total uncertainty than the bias component, but the bias component is not insignificant. For helium mass spectrometer leak rate tests where unit sensitivity alone is not enough, a thorough evaluation of the measurement uncertainty such as the one presented herein should be performed and reported along with the leak rate value.

  19. HIGH RESOLUTION RESISTIVITY LEAK DETECTION DATA PROCESSING and EVALUATION MEHTODS and REQUIREMENTS

    International Nuclear Information System (INIS)

    This document has two purposes: (smbullet) Describe how data generated by High Resolution REsistivity (HRR) leak detection (LD) systems deployed during single-shell tank (SST) waste retrieval operations are processed and evaluated. (smbullet) Provide the basic review requirements for HRR data when Hrr is deployed as a leak detection method during SST waste retrievals

  20. Selection of transition leak size for LLTR series II test A-4

    International Nuclear Information System (INIS)

    The objective of this report is to provide the basis for the selection of this transition leak size for testing in the LLTR. This test, designated as Test A-4, is of particular interest because, of all the larger nonflame-jet-type-leaks, it has the longest dwell time in the vessel before the rupture disc blows, thus terminating the IHTS pressure rise. Its potential for generating secondary leaks is considered high. It is easy to postulate the generation of such a leak starting with small leak wastage and progressing into larger and larger leak sizes by self-wastage and adjacent tube wastage. On the other hand, it is not easy to postulate an instantaneous DEG failure in a properly designed and manufactured steam generator. All small leaks which are not terminated would appear to progress in stages which eventually pass through the transition size before they generate sufficient pressure to burst the rupture disc. For these reasons major emphasis is placed on the transition leak size