WorldWideScience

Sample records for capacity restraint

  1. A Capacity-Restraint Transit Assignment Model When a Predetermination Method Indicates the Invalidity of Time Independence

    Directory of Open Access Journals (Sweden)

    Haoyang Ding

    2015-01-01

    Full Text Available The statistical independence of time of every two adjacent bus links plays a crucial role in deciding the feasibility of using many mathematical models to analyze urban transit networks. Traditional research generally ignores the time independence that acts as the ground of their models. Assumption is usually made that time independence of every two adjacent links is sound. This is, however, actually groundless and probably causes problematic conclusions reached by corresponding models. Many transit assignment models such as multinomial probit-based models lose their effects when the time independence is not valid. In this paper, a simple method to predetermine the time independence is proposed. Based on the predetermination method, a modified capacity-restraint transit assignment method aimed at engineering practice is put forward and tested through a small contrived network and a case study in Nanjing city, China, respectively. It is found that the slope of regression equation between the mean and standard deviation of normal distribution acts as the indicator of time independence at the same time. Besides, our modified assignment method performs better than the traditional one with more reasonable results while keeping the property of simplicity well.

  2. Mechanical restraint in psychiatry

    DEFF Research Database (Denmark)

    Bak, Jesper; Zoffmann, Vibeke; Sestoft, Dorte Maria;

    2014-01-01

    PURPOSE: To examine how potential mechanical restraint preventive factors in hospitals are associated with the frequency of mechanical restraint episodes. DESIGN AND METHODS: This study employed a retrospective association design, and linear regression was used to assess the associations. FINDING...

  3. Physical restraint as positive reinforcement.

    Science.gov (United States)

    Favell, J E; McGimsey, J F; Jones, M L; Cannon, P R

    1981-01-01

    The reinforcing function of physical restraint was analyzed for three retarded individuals who had a history of restraint and appeared to enjoy it. Using a preference paradigm with one participant and a reversal design with two others, we found that an arbitrary response systematically increased for each participant when followed by brief periods of restraint. No comparable increases occurred in conditions in which responses were not reinforced or were followed by stimuli designed to control for the nonrestraint components of the restraint consequence. Results were discussed in terms of three clinical issues: determining the possible role of restraint in maintaining behavior problems such as self-injury in natural settings, preventing or eliminating the reinforcing function of restraint, and using restraint reinforcement in treating behavior problems when this consequence is the only identifiable reinforcer for an individual.

  4. A week of Israeli restraint

    NARCIS (Netherlands)

    Reinhart, T.

    2006-01-01

    In Israeli discourse, Israel is always the side exercising restraint in its conflict with the Palestinians. This was true again for the events of the past week: As the Qassam rockets were falling on the Southern Israeli town of Sderot, it was “leaked” that the Israeli Minister of Defense had directe

  5. 32 CFR 636.34 - Restraint systems.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Restraint systems. 636.34 Section 636.34 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION (SPECIFIC INSTALLATIONS) Fort Stewart, Georgia § 636.34 Restraint systems. (a)...

  6. 77 FR 11625 - Child Restraint Systems

    Science.gov (United States)

    2012-02-27

    ... restraint. \\1\\ 44 FR 72131, December 13, 1979. \\2\\ 60 FR 35126, July 6, 1995. \\3\\ 68 FR 37620, June 24, 2003... NHTSA's responses to the child restraint provisions of Anton's Law. See 70 FR at 51721. Later...- year-old child. 70 FR 51720, August 31, 2005, Docket No. NHTSA-2005- 21245 (RIN 2127-AJ44)....

  7. Acute Cold / Restraint Stress in Castrated Rats

    Directory of Open Access Journals (Sweden)

    Farideh Zafari Zangeneh

    2008-09-01

    Full Text Available Objective: The present study aimed to determine whether castration altered osmotically stimulated vasopressin (VP release and urinary volume and what is the role of endocrine-stress axis in this process.Materials and methods: Totally 108 mice were studied in two main groups of castrated (n=78 and control (n=30. Each group was extracted by acute cold stress (4◦C for 2h/day, restraint stress (by syringes 60cc 2h/day and cold/restraint stress. The castrated group was treated in sub groups of testosterone, control (sesame oil as vehicle of testosterone. Propranolol as blocker of sympathetic nervous system was given to both groups of castrated mice and main control.Results: Our results showed that, there is interactions between testosterone and sympathetic nervous system on vasopressin, because urine volume was decreased only in testoctomized mice with cold/restraint and cold stress (P<0.001; propranolol as the antagonist of sympathetic nervous system could block and increase urine volume in castrated mice. This increased volume of urine was due to acute cold stress, not restraint stress (p<0.001. The role of testosterone, noradrenalin (NA and Vasopressin (VP in the acute cold stress is confirmed, because testosterone could return the effect of decreased urine volume in control group (P<0.001. Conclusion: Considering the effect of cold/restraint stress on urinary volume in castrated mice shows that there is interaction between sex hormone (testosterone, vasopressin and adrenergic systems.

  8. Thermal restraint and fire resistance of columns

    OpenAIRE

    Neves, I. Cabrita; Valente, J. C.; Rodrigues, J. P. Correia

    2002-01-01

    A proposal is made, based on the results of a series of tests and calculations, with the aim of being used as a simple method to correct the value of the critical temperature of steel columns free to elongate, in order to take into account the restraint effect of the structure to which they belong in a practical situation. To better illustrate the possible types of behaviour of heated steel columns with elastic restraint to the thermal elongation, and the reasons why the critical temperature ...

  9. 75 FR 9613 - Draft NIJ Restraints Standard for Criminal Justice

    Science.gov (United States)

    2010-03-03

    ... of Justice Programs Draft NIJ Restraints Standard for Criminal Justice AGENCY: National Institute of Justice, Office of Justice Programs, DOJ. ACTION: Notice of Draft NIJ Restraints Standard for Criminal... Restraints Standard for Criminal Justice'' and (2) a draft companion document entitled, ``NIJ...

  10. Restraint fading and the development of alternative behaviour in the treatment of self-restraint and self-injury.

    Science.gov (United States)

    Lerman, D C; Iwata, B A; Smith, R G; Vollmer, T R

    1994-04-01

    Restraint fading and differential reinforcement were used to reduce the self-injurious behaviour (SIB) and self-restraint of a profoundly retarded man. The variables maintaining both behaviours could not be identified via pre-treatment functional analysis; however, self-restraint exerted at least some stimulus control over SIB. In Phase 1, the subject's topography of self-restraint (wrapping arms in shirt) was replaced with another topography (wrapping wrists in towel) that could be more easily faded to a headband. However, the subject's restraints could not be completely faded, and any movement was accompanied by SIB; thus, in Phase 2, a compliance training procedure was implemented to reduce his SIB while increasing time out of restraint. In Phase 3, the subject was taught to mand for edibles during training sessions. Results indicated that restraint fading combined with the development of alternative behaviour could be an effective treatment procedure for those who engage in both self-restraint and SIB.

  11. On Restraint of and Supervision over Power

    Institute of Scientific and Technical Information of China (English)

    DONG YUNHU

    2007-01-01

    @@ Power is the nucleus of social and political life. Effective restraint on and supervision over the operation of power is the fundamental way of preventing corruption of power, which at the same time constitutes an important indication to democracy and its development in a given country.

  12. Rollover: a methodology for restraint system development

    NARCIS (Netherlands)

    Altamore, P.F.; Ridella, S.A.; Nayef, A.

    2001-01-01

    Concern about crash conditions other than frontal and side crashes has accelerated restraint development with respect to rollover events. Previous analysis of rollover field data indicates the high probability of ejection and consequent serious injury or death to unbelted occupants. Partial ejection

  13. PDBStat: a universal restraint converter and restraint analysis software package for protein NMR

    International Nuclear Information System (INIS)

    The heterogeneous array of software tools used in the process of protein NMR structure determination presents organizational challenges in the structure determination and validation processes, and creates a learning curve that limits the broader use of protein NMR in biology. These challenges, including accurate use of data in different data formats required by software carrying out similar tasks, continue to confound the efforts of novices and experts alike. These important issues need to be addressed robustly in order to standardize protein NMR structure determination and validation. PDBStat is a C/C++ computer program originally developed as a universal coordinate and protein NMR restraint converter. Its primary function is to provide a user-friendly tool for interconverting between protein coordinate and protein NMR restraint data formats. It also provides an integrated set of computational methods for protein NMR restraint analysis and structure quality assessment, relabeling of prochiral atoms with correct IUPAC names, as well as multiple methods for analysis of the consistency of atomic positions indicated by their convergence across a protein NMR ensemble. In this paper we provide a detailed description of the PDBStat software, and highlight some of its valuable computational capabilities. As an example, we demonstrate the use of the PDBStat restraint converter for restrained CS-Rosetta structure generation calculations, and compare the resulting protein NMR structure models with those generated from the same NMR restraint data using more traditional structure determination methods. These results demonstrate the value of a universal restraint converter in allowing the use of multiple structure generation methods with the same restraint data for consensus analysis of protein NMR structures and the underlying restraint data

  14. PDBStat: a universal restraint converter and restraint analysis software package for protein NMR

    Energy Technology Data Exchange (ETDEWEB)

    Tejero, Roberto [Rutgers, The State University of New Jersey, Center for Advanced Biotechnology and Medicine (United States); Snyder, David [William Paterson University, Department of Chemistry (United States); Mao, Binchen; Aramini, James M.; Montelione, Gaetano T., E-mail: guy@cabm.rutgers.edu [Rutgers, The State University of New Jersey, Center for Advanced Biotechnology and Medicine (United States)

    2013-08-15

    The heterogeneous array of software tools used in the process of protein NMR structure determination presents organizational challenges in the structure determination and validation processes, and creates a learning curve that limits the broader use of protein NMR in biology. These challenges, including accurate use of data in different data formats required by software carrying out similar tasks, continue to confound the efforts of novices and experts alike. These important issues need to be addressed robustly in order to standardize protein NMR structure determination and validation. PDBStat is a C/C++ computer program originally developed as a universal coordinate and protein NMR restraint converter. Its primary function is to provide a user-friendly tool for interconverting between protein coordinate and protein NMR restraint data formats. It also provides an integrated set of computational methods for protein NMR restraint analysis and structure quality assessment, relabeling of prochiral atoms with correct IUPAC names, as well as multiple methods for analysis of the consistency of atomic positions indicated by their convergence across a protein NMR ensemble. In this paper we provide a detailed description of the PDBStat software, and highlight some of its valuable computational capabilities. As an example, we demonstrate the use of the PDBStat restraint converter for restrained CS-Rosetta structure generation calculations, and compare the resulting protein NMR structure models with those generated from the same NMR restraint data using more traditional structure determination methods. These results demonstrate the value of a universal restraint converter in allowing the use of multiple structure generation methods with the same restraint data for consensus analysis of protein NMR structures and the underlying restraint data.

  15. Gold Mine or Minefield: Understanding Russian Law on Vertical Restraints

    Directory of Open Access Journals (Sweden)

    Valentina Rucker

    2014-01-01

    Full Text Available While the Russian Federation represents a significant opportunity for growth, that opportunity is coupled with serious risks. As it relates to managing product distribution, Russian vertical restraint law remains significantly more restrictive than that of the U.S. and, since unless a company is fully integrated, it must manage its distribution system by way of vertical agreements, presents a large problem for businesses seeking to conduct business in Russia. While Russia has made significant steps in the right direction, the lack of consistent application of economic analysis to evaluation of vertical restraints leaves companies exposed. Further, the sometimes inconsistent application of the laws also makes it hard to predict how any particular vertical agreement would be evaluated. Neither American nor Russian antitrust laws establish a list of possible vertical restraints. Thus, there is no exhaustive guidance regarding how these restraints should be treated. U.S. antitrust laws, however, generally place all vertical restraints into one of two categories, intrabrand restraints and interbrand restraints. Intrabrand restraints are those that restrain the downstream firm’s freedom with regard to the resale of the product at issue (distribution restrictions. Interbrand restraints are those that restrict a downstream or upstream firm’s freedom to deal with competitors of the firm imposing the restraint (interbrand restrictions. It should be noted that Russian law does not make this distinction.

  16. Gold Mine or Minefield: Understanding Russian Law on Vertical Restraints

    Directory of Open Access Journals (Sweden)

    Valentina Rucker

    2015-02-01

    Full Text Available While the Russian Federation represents a significant opportunity for growth, that opportunity is coupled with serious risks. As it relates to managing product distribution, Russian vertical restraint law remains significantly more restrictive than that of the U.S. and, since unless a company is fully integrated, it must manage its distribution system by way of vertical agreements, presents a large problem for businesses seeking to conduct business in Russia. While Russia has made significant steps in the right direction, the lack of consistent application of economic analysis to evaluation of vertical restraints leaves companies exposed. Further, the sometimes inconsistent application of the laws also makes it hard to predict how any particular vertical agreement would be evaluated. Neither American nor Russian antitrust laws establish a list of possible vertical restraints. Thus, there is no exhaustive guidance regarding how these restraints should be treated. U.S. antitrust laws, however, generally place all vertical restraints into one of two categories, intrabrand restraints and interbrand restraints. Intrabrand restraints are those that restrain the downstream firm’s freedom with regard to the resale of the product at issue (distribution restrictions. Interbrand restraints are those that restrict a downstream or upstream firm’s freedom to deal with competitors of the firm imposing the restraint (interbrand restrictions. It should be noted that Russian law does not make this distinction.

  17. Dietary restraint and heightened reactivity to food.

    Science.gov (United States)

    Brunstrom, Jeffrey M; Yates, Heather M; Witcomb, Gemma L

    2004-03-01

    Previously, studies have explored the relationship between dietary behavior and salivary reactivity to food. Despite this, it remains unclear which behaviors are associated with enhanced reactivity. One problem is that measures of behavior have not been compared directly. In particular, it is unclear whether elevated reactivity is associated with measures of dietary restraint or with measures of failed dietary control and a tendency to overeat. To address this problem, we compared the association between salivary reactivity and scores on the subscales of the Three-Factor Eating Questionnaire (restraint, disinhibition, and hunger). Estimates of reactivity were derived from the difference between a baseline saliva measure and a similar measure taken in close proximity to hot pizza. Our second aim was to explore how salivary reactivity changes after a meal. Female participants (N=40) were tested before and after a lunch (cheese sandwiches). All tended to show reactivity to pizza before but not after lunch. No significant differences were associated with the disinhibition or hunger subscales. However, prelunch reactivity was significantly greater in those participants with high scores on the restraint scale. This does not appear to be related to reported levels of hunger before lunch. Rather, it may reveal an intrinsic difference between the reaction of restrained and unrestrained eaters to food. PMID:15059687

  18. Staff resistance to restraint reduction: identifying & overcoming barriers.

    Science.gov (United States)

    Curran, Staci Silver

    2007-05-01

    Professional organizations, regulating agencies, and hospital administrators have taken a strong stance on restraint reduction policies. When implementing a restraint reduction initiative, it is important to identify the barriers to restraint reduction, such as concern for personal safety, lack of knowledge about and practice using alternate de-escalation skills, and fear of disrupting the therapeutic milieu by using a variety of de-escalation methods. Education aimed to reduce the use of restraints needs to do more than simply provide information. It is important to acknowledge the emotional response of the nursing staff and the culture of the current practice. A variety of educational strategies, including role-playing, and case studies will help identify attitudes, beliefs, and behaviors that are congruent with reducing the use of restraints. If the ultimate goal of restraint reduction is philosophical change, it will eventually lead to a new culture of practice. PMID:17526330

  19. Restraint methods for radiography in dogs and cats

    International Nuclear Information System (INIS)

    Excellent patient restraint techniques are necessary to produce high-quality diagnostic images during survey and contrast radiography and ultrasonography. Use of non manual physical restraint (i.e., devices to hold the patient in position) helps reduce the exposure of veterinary personnel to radiation. Exposure of personnel to radiation should be kept as low as reasonably achievable. Usually, this involves taking the radiograph when no personnel are present in the room. Some procedures, however, require the presence of the veterinarian. No personnel should ever put any part of their bodies in the path of the x-ray beam. Protective gear must be worn. Physical restraint can be facilitated by chemical restraint, which varies from minimal sedation to general anesthesia. Appropriate chemical restraint for radiography is the minimum amount of sedation required for the efficient and safe completion of the radiographic examination. Chemical restraint techniques vary according to the patient's physical status, the type of examination, and the skill of the examiner in non manual restraint techniques. This article describes techniques for non manual restraint and protocols for chemical restraint for dogs and cats

  20. Deep venous thrombosis and pulmonary embolism following physical restraint

    DEFF Research Database (Denmark)

    Laursen, S B; Jensen, T N; Bolwig, T;

    2005-01-01

    OBJECTIVE: We describe a case of deep venous thrombosis (DVT) and pulmonary embolism (PE) following the use of physical restraint in a patient with a diagnosis of acute delusional psychotic disorder. METHOD: A new case report of DVT and PE associated with prolonged physical restraint is presented...... physical restraint may occur in spite of no pre-existing risk factors. Medical guidelines for the prevention of thrombosis following physical restraint are presented. Despite the absence of controlled trials of treatment effectiveness, the catastrophic outcome of DVT and PE warrants early and vigorous...

  1. Development and psychometric properties of the Smoking Restraint Questionnaire.

    Science.gov (United States)

    Blake, Grant A; Ferguson, Stuart G; Palmer, Matthew A; Shiffman, Saul

    2016-03-01

    Restraint is a component of self-control that focuses on the deliberate reduction of an undesired behavior and is theorized to play a role in smoking reduction and cessation. However, there exists no instrument to assess smoking restraint. This research aimed to develop the Smoking Restraint Questionnaire (SRQ) to meet this need. Participants were 406 smokers (48% female; 52.2% nondaily) with a mean age of 38.83 years (SD = 12.05). They completed a baseline questionnaire designed to assess smoking restraint. They also completed 21 days of ecological momentary assessment (EMA), during which they recorded each cigarette smoked and answered questions related to planned restraint every morning, and restraint attempts every evening. The 4-item questionnaire of smoking restraint was found to fit a single factor (root mean square error of approximation = .038, comparative fit index = .99, Tucker-Lewis index = .99), and the resulting composite was reliable (composite reliability = 0.74). The questionnaire contains items that assess the setting of weekly restraint goals and attempts at not lighting up when tempted to smoke. Participant SRQ scores positively correlated with EMA data on plans to restrain (p relation to the intention and behaviors of smoking reduction. The SRQ is promising as a measure of smoking restraint and may enable further research and insights into smoking reduction and cessation. PMID:26551266

  2. CETA truck and EVA restraint system

    Science.gov (United States)

    Beals, David C.; Merson, Wayne R.

    1991-01-01

    The Crew Equipment Translation Aid (CETA) experiment is an extravehicular activity (EVA) Space Transportation System (STS) based flight experiment which will explore various modes of transporting astronauts and light equipment for Space Station Freedom (SSF). The basic elements of CETA are: (1) two 25 foot long sections of monorail, which will be EVA assembled in the STS cargo bay to become a single 50 ft. rail called the track; (2) a wheeled baseplate called the truck which rolls along the track and can accept three cart concepts; and (3) the three carts which are designated manual, electric, and mechanical. The three carts serve as the astronaut restraint and locomotive interfaces with the track. The manual cart is powered by the astronaut grasping the track's handrail and pulling himself along. The electric cart is operated by an astronaut turning a generator which powers the electric motor and drives the cart. The mechanical cart is driven by a Bendix type transmission and is similar in concept to a man-propelled railroad cart. During launch and landing, the truck is attached to the deployable track by means of EVA removable restraint bolts and held in position by a system of retractable shims. These shims are positioned on the exterior of the rail for launch and landing and rotate out of the way for the duration of the experiment. The shims are held in position by strips of Velcro nap, which rub against the sides of the shim and exert a tailored force. The amount of force required to rotate the shims was a major EVA concern, along with operational repeatability and extreme temperature effects. The restraint system was tested in a thermal-vac and vibration environment and was shown to meet all of the initial design requirements. Using design inputs from the astronauts who will perform the EVA, CETA evolved through an iterative design process and represented a cooperative effort.

  3. Measuring dietary restraint status: Comparisons between the Dietary Intent Scale and the Restraint Scale

    Directory of Open Access Journals (Sweden)

    Jessica A Boyce

    2015-04-01

    Full Text Available The measurement of young women’s self-reported dietary restraint status is complex. Compared to Herman and Polivy’s commonly utilized Restraint Scale (RS, Stice’s Dietary Intent Scale (DIS is less understood. Because the DIS is becoming a popular research tool, it is important to understand how this scale compares to more traditional measures of restraint. We conducted two correlational studies (Study 1 N = 110; Study 2 N = 216 to ascertain the similarities and the differences between the DIS and - as a comparison measure - the well-researched RS. We explored how the two scales were related to several body image variables (e.g., thin-ideal internalization; with a range of self-regulatory variables (e.g., dispositional self-control; with observed food intake during a taste test; and with 18-month weight change (Study 2 only. Participants were female University students and were not selected for dieting or disordered eating. Unlike RS scores, DIS scores were not significantly correlated with the majority of variables tapping into unsuccessful self-regulation. However, our data also highlighted similarities between the two restraint scales (e.g., association with 18-month weight-loss and demonstrated that not only were participants’ DIS scores un-related to unsuccessful self-regulatory variables, neither were they related to the variables tapping into successful self-regulation.

  4. Alcohol, Appetite and Loss of Restraint.

    Science.gov (United States)

    Caton, Samantha J; Nolan, Laurence J; Hetherington, Marion M

    2015-03-01

    Alcoholic beverages have long been associated with feasts, celebration and marking special events. Today, it is commonplace to consume alcoholic beverages before, with and/or after a meal. Alcohol provides additional pleasure to the meal and enhances appetite. However, consuming an alcoholic beverage with or before a meal is associated with poor short-term energy compensation; energy from alcohol is additive to total energy intake with the added property of stimulating further eating. Limiting alcohol intake is an obvious means to reduce total energy intake for those who wish to lose weight. However, dieters and restrained eaters drink more and report greater binge drinking than unrestrained eaters despite employing cognitive strategies to reduce their intake. Increased intake may be attributable to greater attentional bias to alcohol related cues as well as to food cues, since these are more salient to those limiting intake. Alcohol increases energy intake in dieters, in part due to abandonment of restraint (disinhibition) and consumption of forbidden items including alcohol exacerbates attempts to resist temptation. Paradoxically, links between binge drinking or increased drinking frequency to overweight and obesity may be mediated by dietary restraint. Efforts to limit food and alcohol intake for weight control appear to be unsuccessful and have the net effect of promoting overconsumption. The potential role of restrained eating in the association between alcohol, appetite and obesity has been overlooked by much of the current research and further investigation of this is therefore warranted.

  5. 75 FR 67233 - Federal Motor Vehicle Safety Standards; Head Restraints

    Science.gov (United States)

    2010-11-02

    ... Positions b. Leadtime for Small Vehicle Manufacturers c. Static Lockout of Active Head Restraints During... Positions B. NHTSA Declines To Permit Additional Leadtime for Small Vehicle Manufacturers C. Static Lockout... Point for Static Testing of Active Mechanical Head Restraints 2. NHTSA Declines To Specify a...

  6. Individualized music--a different approach to the restraint issue.

    Science.gov (United States)

    Janelli, Linda M; Kanski, Genevieve W; Wu, Yow-Wu Bill

    2002-01-01

    Rehabilitation nurses who work with geriatric patients are concerned about reliance on physical restraints, as are all nurses. Controversy exists as to the benefits and risks, as well as the ethical and legal consequences, of their use. Nurses are ambivalent about using restraints, believing that they affect patients' freedom, self-respect, and self-reliance; they also often believe that there are no appropriate alternatives. This pilot study explored the use of music as a potential alternative to using physical restraints with hospitalized patients. The research question was: Will patients have more positive behaviors, as measured by the Restraint Music Response Instrument (RMRI), while out of restraints and listening to preferred music compared with the patients not listening to music who are out of restraints while being observed? Forty medical-surgical patients participated in the study and were randomized into either the experimental group (music) or the control group (no music). The mean age of the 21 males and 19 females was 76.6 years (range 56-94). A t test for equality of means was used to determine if there were differences in the number of positive and negative behaviors in the preintervention, intervention, and postintervention phases between the two groups. There was a significant difference (p < .01) in behaviors during the intervention phase. Patients who listened to preferred music had more positive behaviors while out of restraints than patients who were out of restraints but not exposed to music.

  7. High School Students' Publication Rights and Prior Restraint.

    Science.gov (United States)

    Huffman, John L.; Trauth, Denise M.

    1981-01-01

    Federal court decisions on high school students' publication rights in the Second, Fourth, Fifth, and Seventh Circuits reveal substantial disagreement about school officials' power of prior restraint over student publications. The courts' opinions range from approval of broad powers of prior restraint to denial of any power. (Author/RW)

  8. 28 CFR 570.44 - Supervision and restraint requirements.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Supervision and restraint requirements... PROGRAMS AND RELEASE COMMUNITY PROGRAMS Escorted Trips § 570.44 Supervision and restraint requirements. Inmates under escort will be within the constant and immediate visual supervision of escorting staff...

  9. Child restraint system for children in cars - CREST results

    NARCIS (Netherlands)

    Schrooten, M.; Cassan, F.; Trosseille, X.

    2001-01-01

    Child restraint systems (CRS) for cars are intended to protect children in the case of a car accident. Unfortunately their effectiveness is still too low: in the range 30-50% when it would be expected to be much higher. The low effectiveness of child restraint systems can partly be explained for the

  10. Mechanical and pharmacological restraints in acute psychiatric wards--why and how are they used?

    Science.gov (United States)

    Knutzen, Maria; Bjørkly, Stål; Eidhammer, Gunnar; Lorentzen, Steinar; Helen Mjøsund, Nina; Opjordsmoen, Stein; Sandvik, Leiv; Friis, Svein

    2013-08-30

    Restraint use has been reported to be common in acute psychiatry, but empirical research is scarce concerning why and how restraints are used. This study analysed data from patients' first episodes of restraint in three acute psychiatric wards during a 2-year study period. Logistic regression analyses were used to identify predictors for type and duration of restraint. The distribution of restraint categories for the 371 restrained patients was as follows: mechanical restraint, 47.2%; mechanical and pharmacological restraint together, 35.3%; and pharmacological restraint, 17.5%. The most commonly reported reason for restraint was assault (occurred or imminent). It increased the likelihood of resulting in concomitant pharmacological restraint. Female patients had shorter duration of mechanical restraint than men. Age above 49 and female gender increased the likelihood of pharmacological versus mechanical restraint, whereas being restrained due to assault weakened this association. Episodes with mechanical restraint and coinciding pharmacological restraint lasted longer than mechanical restraint used separately, and were less common among patients with a personality disorder. Diagnoses, age and reason for restraint independently increased the likelihood for being subjected to specific types of restraint. Female gender predicted type of restraint and duration of episodes.

  11. Self-restraint as positive reinforcement for self-injurious behavior.

    Science.gov (United States)

    Smith, R G; Lerman, D C; Iwata, B A

    1996-01-01

    Many individuals who engage in self-injurious behavior (SIB) also exhibit self-restraint. We compared rates of SIB exhibited by a 32-year-old woman diagnosed with profound retardation across conditions in which access to restraint was (a) continuously available, (b) presented as a consequence for SIB, or (c) unavailable. Rates of SIB increased when access to restraint was contingent upon SIB and decreased when restraint was unavailable, suggesting that self-restraint functioned as positive reinforcement for SIB.

  12. Wheelchair integrated occupant restraints: feasibility in frontal impact.

    Science.gov (United States)

    VanRoosmalen, L; Bertocci, G E; Ha, D; Karg, P

    2001-12-01

    Individuals often use their wheelchair as a motor vehicle seat when traveling in motor vehicles. The current use of fixed vehicle-mounted wheelchair occupant restraint systems (FWORSs) often results in poor belt fit and discomfort. Additionally, satisfaction, usability and usage rate of FWORSs during transit use are often low. The automotive industry has shown improved occupant restraint usage, belt fit and injury protection when integrating the upper torso and pelvic restraint in a motor vehicle seat. This study compared occupant injury measures of a FWORS to a concept wheelchair integrated restraint system (WIRS) using a 20g frontal sled impact test with a 30 mph change in velocity. Neck loads, neck moments, head, pelvis and chest acceleration, sternum compression and knee and head excursion data were recorded from the wheelchair seated 50th percentile male hybrid III anthropomorphic test dummy (ATD). The WIRS resulted in a lower head injury criteria (HIC) value, lower sternum compression and a lower upper-torso restraint load than the FWORS. Compared with the FWORS, increased head, knee and wheelchair excursions and higher neck loads and moments were measured in the WIRS test. Both restraint scenario injury parameters were complied with occupant injury criteria based on General Motors Injury Assessment Reference Values (GM-IARVs) and occupant kinematic requirements defined by the Society of Automotive Engineers (SAE) voluntary standard, J2249. A higher motion criteria index was calculated for the WIRS scenario and a comparable combined injury criteria index was calculated for both restraint scenarios. The sled impact test showed WIRS concept feasibility, facilitating further development by industrial manufacturers who might further want to pursue this restraint principle to increase wheelchair occupant safety and comfort during transport in motor vehicles.

  13. Women, sex and marriage. Restraint as a feminine strategy.

    Science.gov (United States)

    Kishwar, M

    1997-01-01

    The expression of sexuality varies in different cultures, and most societies attempt to control sexuality through the institution of marriage. In the West, the availability of cheap, effective contraceptives separated sex from reproduction and promoted the sexual liberation of women. Today, while divorce is common, sexually liberated people nevertheless engage in a form of serial monogamy. Sexual liberation in the West causes women to be exploited by men and creates instability in nuclear families. In India, feminism is tempered by a belief that familial rights have precedence over individual rights. India women practice sexual self-denial after being widowed to protect their children and to gain power and respect in the community. The power of chastity was illustrated by Mahatma Gandhi who marshalled his spiritual forces to fight for independence. The stories of many individual women illustrate how they attain status and prestige through chastity. Other women maintain absolute marital faithfulness as a marital strategy to control wayward husbands. These women deemphasize their roles as wives and emphasize their roles as mothers. The children of such women often recognize their sacrifices and become their strongest allies. On the other hand, examples of women who have chosen sexual freedom show that such a choice places them at the mercy of men, makes them social outcasts, and causes other women to distrust them as competitors for their husbands. In patriarchal societies, women can not win if they try to mimic men's capacity for irresponsible sex. Sexual freedom can only work for women in matrilineal communities that shun marriage in favor of strong ties within a woman's natal family. Indian women rooted in the extended family enjoy the resilience and flexibility attendant upon playing a larger role than simply pleasing men. Opting for sexual restraint can be an effective though costly strategy to achieve the sympathy and support of an extended family when a man is

  14. Women, sex and marriage. Restraint as a feminine strategy.

    Science.gov (United States)

    Kishwar, M

    1997-01-01

    The expression of sexuality varies in different cultures, and most societies attempt to control sexuality through the institution of marriage. In the West, the availability of cheap, effective contraceptives separated sex from reproduction and promoted the sexual liberation of women. Today, while divorce is common, sexually liberated people nevertheless engage in a form of serial monogamy. Sexual liberation in the West causes women to be exploited by men and creates instability in nuclear families. In India, feminism is tempered by a belief that familial rights have precedence over individual rights. India women practice sexual self-denial after being widowed to protect their children and to gain power and respect in the community. The power of chastity was illustrated by Mahatma Gandhi who marshalled his spiritual forces to fight for independence. The stories of many individual women illustrate how they attain status and prestige through chastity. Other women maintain absolute marital faithfulness as a marital strategy to control wayward husbands. These women deemphasize their roles as wives and emphasize their roles as mothers. The children of such women often recognize their sacrifices and become their strongest allies. On the other hand, examples of women who have chosen sexual freedom show that such a choice places them at the mercy of men, makes them social outcasts, and causes other women to distrust them as competitors for their husbands. In patriarchal societies, women can not win if they try to mimic men's capacity for irresponsible sex. Sexual freedom can only work for women in matrilineal communities that shun marriage in favor of strong ties within a woman's natal family. Indian women rooted in the extended family enjoy the resilience and flexibility attendant upon playing a larger role than simply pleasing men. Opting for sexual restraint can be an effective though costly strategy to achieve the sympathy and support of an extended family when a man is

  15. Risks Facing the Retailers and Vertical Restraints

    Directory of Open Access Journals (Sweden)

    Dzagurova Nataliya, B.

    2016-07-01

    Full Text Available Vertical restraints such as exclusive territories may be considered as an alternative to the compensation paid to retailers for taking the risks associated with market shocks. For the first time this approach has been put forward in (Rey and Tirole, 1986. In (Hansen and Motta, 2015 this concept has been further developed, but these authors have come a diametrically opposite result to what Rey & Tirole had reported. The goal of both papers was to compare exclusive territories and retailers’ competition from the point of view of the supplier. In (Rey and Tirole, 1986 the competition was the preferred solution, in (Hansen and Motta, 2015 - the exclusive territories. The explanation of this discrepancy proposed in (Hansen and Motta, 2015 doesn't look convincing enough. The paper proposes a new explanation based on the analysis of the attractiveness of the considered lotteries for the retailers. In (Rey and Tirole, 1986 they were ready to pay for the lottery, but in (Hansen and Motta, 2015 - pretend to get a compensation. Accordingly, in the first case the supplier prefers to allow competition between dealers, in the second - to provide exclusive territories in order to reduce the compensation to be paid to the dealer for participating in the lottery. The paper discusses that the better solution is to consider not the risks associated with market shocks, but the retailers’ risks associated with the so called «cooperative specific investments» (manufacturer can prefer another partner on ex post stage. Trying to support the retailers’ incentives to make cooperative investments, supplier voluntarily redistributes control in favor of retailers.

  16. Development and testing of restraints for nuclear piping systems

    International Nuclear Information System (INIS)

    As an alternative to current practice of pipe restraint within nuclear power plants it has been proposed to adopt restraints capable of dissipating energy in the piping system. The specific mode of energy dissipation focused upon in these studies is the plastic yielding of steels utilizing relative movement between the pipe and the base of the restraint, a general mechanism which has been proven as reliable in several allied studies. This report discusses the testing of examples of two energy-absorbing devices, the results of this testing and the conclusions drawn. This study concentrated on the specific relevant performance characteristics of hysteretic behavior and degradation with use. The testing consisted of repetitive continuous loadings well into the plastic ranges of the devices in a sinusoidal or random displacement controlled mode

  17. Fast Flux Test Facility core restraint system performance

    International Nuclear Information System (INIS)

    Characterizing Fast Flux Test Facility (FFTF) core restraint system performance has been ongoing since the first operating cycle. Characterization consists of prerun analysis for each core load, in-reactor and postirradiation measurements of subassembly withdrawal loads and deformations, and using measurement data to fine tune predictive models. Monitoring FFTF operations and performing trend analysis has made it possible to gain insight into core restraint system performance and head off refueling difficulties while maximizing component lifetimes. Additionally, valuable information for improved designs and operating methods has been obtained. Focus is on past operating experience, emphasizing performance improvements and avoidance of potential problems. 4 refs., 12 figs., 2 tabs

  18. Making the transition to restraint-free care.

    Science.gov (United States)

    Blakeslee, J A; Goldman, B D; Papougenis, D; Torell, C A

    1991-02-01

    When implementing a change to restraint-free care, education and communication at all levels of the organization are powerful strategies to overcome resistance. Within each facility, there are at least six identifiable groups, with attitudes based on their educational background, life experiences and perceptions that are targets for change. An anonymous attitudinal survey and sensitivity session serve as effective "unfreezing" tools for all levels of staff to express concerns regarding physical restraints and to recognize the need for change. Change requires a slow, methodical system where specific alternatives are gradually introduced. Success with the easier cases encourages staff to continue efforts with more challenging cases. PMID:1902243

  19. 49 CFR 571.213 - Standard No. 213; Child restraint systems.

    Science.gov (United States)

    2010-10-01

    ... Motor Vehicle Safety Standards § 571.213 Standard No. 213; Child restraint systems. S1. Scope. This... vehicle crashes and in aircraft. S3. Application. This standard applies to passenger cars, multipurpose.... S4. Definitions. Add-on child restraint system means any portable child restraint system....

  20. Public Policy on Physical Restraint of Children with Disabilities in Public Schools

    Science.gov (United States)

    McAfee, James K.; Schwilk, Christopher; Mitruski, Megan

    2006-01-01

    The US Constitution, federal and state legislatures, courts, and regulations permit physical restraint for both therapeutic (i.e., behavior change) and risk prevention purposes. Although most venues limit restraint as punishment, no government entity prohibits use of physical restraint as a response to imminent danger. This paper provides a…

  1. Systematic Assessment of the Effects of an All-Atom Force Field and the Implicit Solvent Model on the Refinement of NMR Structures with Subsets of Distance Restraints

    International Nuclear Information System (INIS)

    Employment of a time consuming, sophisticated calculation using the all-atom force field and generalized-Born implicit solvent model (GBIS) for refinement of NMR structures has become practical through advances in computational methods and capacities. GBIS refinement improves the qualities of the resulting NMR structures with reduced computational times. However, the contribution of GBIS to NMR structures has not been sufficiently studied in a quantitative way. In this paper, we report the effects of GBIS on the refined NMR structures of ubiquitin (UBQ) and GB1 with subsets of distance restraints derived from experimental data. Random omission prepared a series of distance restraints 0.05, 0.1, 0.3, 0.5, and 0.7 times smaller. For each number, we produced five different restraints for statistical analysis. We then recalculated the NMR structures using CYANA software, followed by GBIS refinements using the AMBER package. GBIS improved both the precision and accuracy of all the structures, but to varied levels. The degrees of improvement were significant when the input restraints were insufficient. In particular, GBIS enabled GB1 to form an accurate structure even with distance restraints of 5%, revealing that the root-mean-square deviation was less than 1 A from the X-ray backbone structure. We also showed that the efficiency of searching the conformational space was more important for finding accurate structures with the calculation of UBQ with 5% distance restraints than the number of conformations generated. Our data will provide a meaningful guideline to judge and compare the structural improvements by GBIS

  2. Workshop on strategies to increase the use of restraint systems.

    NARCIS (Netherlands)

    Maekinen, T. Hagenzieker, M. Grant, B. Valtonen, J. Lassare, S. Page, Y. Heinrich, H. Broughton, J. & Knaff, R.

    1992-01-01

    At the conference Strategic Highway Research Program and Traffic Safety at two Continents in Gothenburg, Sweden, September 18-20, 1991, a workshop on "Strategies to increase the use of restraint systems" was held. Following an introduction of the background paper, seven national reports on seat belt

  3. The Cost of Prior Restraint: "U. S. v. The Progressive."

    Science.gov (United States)

    Soloski, John; Dyer, Carolyn Stewart

    Increased litigation and rising litigation costs threaten the future of newspapers and magazines. A case study was conducted to determine the costs and effects of "United States v. 'The Progressive,'" a prior restraint case over the publication in 1979 of an article on the hydrogen bomb. "The Progressive," which operates at a deficit, spent almost…

  4. Restraints in daily care for people with moderate intellectual disabilities

    NARCIS (Netherlands)

    van der Meulen, A.P.S.; Hermsen, Maaike; Embregts, P.J.C.M.

    2016-01-01

    Background: Self-determination is an important factor in improving the quality of life of people with moderate intellectual disabilities. A focus on self-determination implies that restraints on the freedom of people with intellectual disabilities should be decreased. In addition, according to the D

  5. Manual restraint and shows of force: the City-128 study.

    Science.gov (United States)

    Bowers, Len; Van Der Merwe, Marie; Paterson, Brodie; Stewart, Duncan

    2012-02-01

    Manual restraint is used to manage disturbed behaviour by patients. This study aimed to assess the relationship of manual restraint and show of force to conflict behaviours, the use of containment methods, service environment, physical environment, patient routines, staff characteristics, and staff group variables. Data from a multivariate, cross-sectional study of 136 acute psychiatric wards in England were used to conduct this analysis. Manual restraint was used less frequently on English acute psychiatric wards (0.20 incidents per day) than show of force (0.28 incidents per day). Both were strongly associated with the proportion of patients subject to legal detention, aggressive behaviours, and the enforcement of treatment and detention. Medical, nursing, and security guard staff provision were associated in different ways with variations in the use of these coercive interventions. An effective ward structure of rules and routines was associated with less dependence on these control methods. Training for manual restraint should incorporate the scenarios of attempted absconding and enforcement of treatment, as well as violent behaviour. Attempts to lessen usage of these interventions could usefully focus on increasing the availability of medical staff to patients, reducing reliance on security guards and establishing a good ward structure. PMID:21733054

  6. Reward Improves Cancellation and Restraint Inhibition across Childhood and Adolescence

    Science.gov (United States)

    Sinopoli, Katia J.; Schachar, Russell; Dennis, Maureen

    2011-01-01

    Inhibitory control allows for the regulation of thought and action and interacts with motivational variables, such as reward, to modify behavior adaptively as environments change. The authors examined the effects of reward on two distinct forms of inhibitory control, cancellation and restraint. Typically developing children and adolescents…

  7. JLigand: a graphical tool for the CCP4 template-restraint library

    Energy Technology Data Exchange (ETDEWEB)

    Lebedev, Andrey A., E-mail: andrey.lebedev@stfc.ac.uk [STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot OX11 0QX (United Kingdom); Young, Paul [University of York, Heslington, York YO10 5DD (United Kingdom); Isupov, Michail N. [University of Exeter, Stocker Road, Exeter EX4 4QD (United Kingdom); Moroz, Olga V.; Vagin, Alexey A. [University of York, Heslington, York YO10 5DD (United Kingdom); Murshudov, Garib N. [MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH (United Kingdom); STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot OX11 0QX (United Kingdom)

    2012-04-01

    The CCP4 template-restraint library defines restraints for biopolymers, their modifications and ligands that are used in macromolecular structure refinement. JLigand is a graphical editor for generating descriptions of new ligands and covalent linkages. Biological macromolecules are polymers and therefore the restraints for macromolecular refinement can be subdivided into two sets: restraints that are applied to atoms that all belong to the same monomer and restraints that are associated with the covalent bonds between monomers. The CCP4 template-restraint library contains three types of data entries defining template restraints: descriptions of monomers and their modifications, both used for intramonomer restraints, and descriptions of links for intermonomer restraints. The library provides generic descriptions of modifications and links for protein, DNA and RNA chains, and for some post-translational modifications including glycosylation. Structure-specific template restraints can be defined in a user’s additional restraint library. Here, JLigand, a new CCP4 graphical interface to LibCheck and REFMAC that has been developed to manage the user’s library and generate new monomer entries is described, as well as new entries for links and associated modifications.

  8. Poor compliance with child safety restraint use while travelling.

    LENUS (Irish Health Repository)

    Fallon, R

    2011-02-01

    Road traffic accidents are a leading cause of death of children. It is the law that all children should be appropriately secured when traveling in vehicles. The aim of this study was to evaluate parental conformity with these regulations and to test if advice given at a Paediatric outpatient clinic could improve compliance. Two groups were assigned, an intervention group (parents given an information leaflet and a clear explanation about appropriate restraints for their children) and a non-intervention group (received no information). They were contacted again after 2 months and asked regarding compliance. A total of 394 children from 186 families were initially given the questionnaire. Nearly one third of children (29.2%) were not using any restraint while travelling rising to 35.3% on follow up. This study concluded that once off parental education made negligible difference to an already inconsistent and haphazard approach to compliance with safety regulations.

  9. Physical restraint produces rapid acquisition of the pigeon's key peck

    OpenAIRE

    Locurto, C. M.; Travers, Tania; Terrace, H S; Gibbon, John

    1980-01-01

    The acquisition and maintenance of autoshaped key pecking in pigeons was studied as a function of intertrial interval. At each of six intervals, which ranged from 12 seconds to 384 seconds, four pigeons were physically restrained during training while four other pigeons were not restrained. Restrained subjects acquired key pecking faster and with less intragroup variability at each interval. The effects of restraint were specific to acquisition and were not evident in maintained responding af...

  10. Development of restraint material and tucked fabric joints

    Science.gov (United States)

    Mcmullen, J. M.

    1975-01-01

    A study was conducted to evaluate and select a suitable restraint material for the exterior of space suits pressurized to 4.0 PSID for normal operations, and to develop and improve tucked fabric joints for motions associated with the human shoulder, elbow, knee, waist, hip, ankle, and wrist. The many attributes of the end items are summarized to include structural integrity, simplicity, low maintenance, lightweight, high durability, low elongation, full range mobility, long life, and resistance to degradation in the operational environment.

  11. Stability of Thin-Walled Beams with Lateral Continuous Restraint

    Directory of Open Access Journals (Sweden)

    Balázs Ivan

    2015-06-01

    Full Text Available Metal beams of thin-walled cross-sections have been widely used in building industry as members of load-bearing structures. Their resistance is usually limited by lateral torsional buckling. It can be increased in case a beam is laterally supported by members of cladding or ceiling construction. The paper deals with possibilities of determination of critical load of thin-walled beams with lateral continuous restraint which is crucial for beam buckling resistance assessment

  12. Voluntary export restraints and resource allocation in exporting countries

    OpenAIRE

    De Melo, Jaime; WINTERS, L Alan

    1990-01-01

    Most literature on voluntary export restraints ( VERs ) analyzes the welfare costs of VERs to consumers in the importing country. The authors propose a method for measuring the effects of a VER on the productivity of factors employed in the exporting industry. Their model measures how a VER affects both revenues and efficiency in an exporting industry. They used the model to estimate the effects of the U.S. Orderly Marketing Agreement ( OMA ) on Korean producers of leather footwear ( 1977 - 8...

  13. Modulation of Cortical Interhemispheric Interactions by Motor Facilitation or Restraint

    Directory of Open Access Journals (Sweden)

    Ana Cristina Vidal

    2014-01-01

    Full Text Available Cortical interhemispheric interactions in motor control are still poorly understood and it is important to clarify how these depend on inhibitory/facilitatory limb movements and motor expertise, as reflected by limb dominance. Here we addressed this problem using functional magnetic resonance imaging (fMRI and a task involving dominant/nondominant limb mobilization in the presence/absence of contralateral limb restraint. In this way we could modulate excitation/deactivation of the contralateral hemisphere. Blocks of arm elevation were alternated with absent/present restraint of the contralateral limb in 17 participants. We found the expected activation of contralateral sensorimotor cortex and ipsilateral cerebellum during arm elevation. In addition, only the dominant arm elevation (hold period was accompanied by deactivation of ipsilateral sensorimotor cortex, irrespective of presence/absence of contralateral restraint, although the latter increased deactivation. In contrast, the nondominant limb yielded absent deactivation and reduced area of contralateral activation upon restriction. Our results provide evidence for a difference in cortical communication during motor control (action facilitation/inhibition, depending on the “expertise” of the hemisphere that controls action (dominant versus nondominant. These results have relevant implications for the development of facilitation/inhibition strategies in neurorehabilitation, namely, in stroke, given that fMRI deactivations have recently been shown to reflect decreases in neural responses.

  14. The evolution of reproductive restraint through social communication.

    Science.gov (United States)

    Werfel, Justin; Bar-Yam, Yaneer

    2004-07-27

    The evolution of altruistic behavior through group selection is generally viewed as possible in theory but unlikely in reality, because individual selection favoring selfish strategies should act more rapidly than group selection favoring cooperation. Here we demonstrate the evolution of altruism, in the form of conditional reproductive restraint based on an explicitly social mechanism, modulated by intrapopulation communication comprising signal and evolved response, in a spatially distributed predatory/parasitic/pathogenic model system. The predatory species consistently comes to exploit a signal implying overcrowding, individuals constraining their reproduction in response, with a corresponding increase in equilibrium reproduction rate in the absence of signal. This signaled restraint arises in a robust way for a range of model spatial systems; it outcompetes non-signal-based restraint and is not vulnerable to subversion by noncooperating variants. In these systems, communication is used to evaluate population density and regulate reproduction accordingly, consistent with central ideas of Wynne-Edwards [Wynne-Edwards, V. C. (1962) Animal Dispersion in Relation to Social Behavior (Hafner, New York)], whose claims about the evolutionary importance of group selection helped ignite decades of controversy. This quantitative simulation model shows how the key evolutionary transition from solitary living to sociality can occur. The process described here of cooperation evolving through communication may also help to explain other major evolutionary transitions such as intercellular communication leading to multicellular organisms.

  15. Construct Validation of the Portuguese Version of the Restraint Scale

    Directory of Open Access Journals (Sweden)

    João Carvalho

    2016-08-01

    Full Text Available AimThe main purpose of this study was to adapt the Restraint Scale (RS to Portuguese and examine its psychometric properties, specifically its construct validity.MethodIn this study, 238 normal-weight adults (82% women; Mean age = 36.6, SD = 15.0 participated in an online survey containing measures of Restraint Scale, Three Factor Eating Questionnaire, Dutch Eating Behaviour Questionnaire, and Body Dissatisfaction and Drive for Thinness scales.ResultsExploratory factor analyses corroborated the two-factors structure found in previous studies, in particular when three items without clear factorial assignment and low correlation were excluded. A final two-factors version of the RS containing seven items presented a very good fit to the measurement model and good internal consistency. Confirmatory factor analysis of the 7-items RS in relation to a three-factor model of overeating, dieting and body dissatisfaction measures revealed that the RS was the only restraint measure loading in all three factors.ConclusionThis suggests that the 7-items Portuguese version of the RS has good psychometric properties and unique features that lend it appropriate to identify and study unsuccessful chronic dieters.

  16. Estimation of restraint stress in rats using salivary amylase activity.

    Science.gov (United States)

    Matsuura, Tetsuya; Takimura, Ryo; Yamaguchi, Masaki; Ichinose, Mitsuyuki

    2012-09-01

    The rat is an ideal model animal for studying physical and psychological stresses. Recent human studies have shown that salivary amylase activity is a useful biomarker of stress in our social life. To estimate the usefulness of amylase activity as a biomarker of stress in rats, we analyzed changes in physiological parameters including amylase activity and anatomical variables, which were induced by a mild restraint of paws (10 min, 3 times/week, 9 weeks). The quantities of food and water intake and excretion amount of the stress rats were smaller than those of the control rats during the experimental period (5-13 weeks). The body weight of the stress rats decreased compared with that of the control rats. Moreover, the enlargement of the adrenal gland was confirmed in the stress rats, indicating that the mild restraint caused a chronic stress response. The amylase activities of the stress rats were significantly greater than those of the control rats at 5 weeks of age. However, the amylase activity of the stress rats decreased compared with that of the control rats after 6 weeks of age. These results indicate that amylase activity is increased by acute stress and reduced by chronic stress, which is caused by repeated restraint stress. In conclusion, amylase activity is a useful biomarker of acute and chronic stresses in rats. PMID:22753135

  17. Coping with budget restraint in a Scandinavian welfare state

    DEFF Research Database (Denmark)

    Nielsen, Annemette Ljungdalh; Holm, Lotte; Lund, Thomas Bøker

    2015-01-01

    The purpose of this study was to investigate how different types of households react to experiences of food budget restraint in Denmark. The study applied a mixed method design, based on survey data and on qualitative interviews. The qualitative data source consisted of interviews with 30 individ...... even in a Scandinavian welfare state context and that certain ‘tipping points’ ought to be observed between the possibility for positive or negative consequences of food budget cuts in Danish households.......The purpose of this study was to investigate how different types of households react to experiences of food budget restraint in Denmark. The study applied a mixed method design, based on survey data and on qualitative interviews. The qualitative data source consisted of interviews with 30...... institute GfK ConsumerTracking Scandinavia. Using both data sources the study explored how shopping, storing, cooking and eating practices changed as a consequence of experienced restraints on the food budget. The quantitative results revealed how differences in terms of application of various types...

  18. Effect of restraint stress on nociceptive responses in rats: role of the histaminergic system.

    Science.gov (United States)

    Ibironke, G F; Mordi, N E

    2011-12-20

    Stress induced analgesia (SIA) is well known, but the reverse phenomenon, hyperalgesia is poorly documented. This study investigated the role of the histaminergic system in restraint stress hyperalgesia in rats, using thermal stimulation method (hot plate and tail flick tests). Paw licking and tail withdrawal latencies were taken before and after restraint for about one hour. Significant decreases (p<0.05) were obtained in these latencies after the restraint in both tests. Administration of H1 and H2 receptor blockers, chlorpheniramine and cimetidine respectively 30 mins before the restraint still resulted in significant reductions (p<0.05) in these latencies, connoting the persistence of hyperalgesia, showing that histamine H1 and H2 receptors did not participate in the mechanism of restraint stress hyperalgesia. We therefore suggest a histaminergic independent mechanism for restraint stress induced hyperalgesia.

  19. Behavioral effects of acclimatization to restraint protocol used for awake animal imaging.

    Science.gov (United States)

    Reed, Michael D; Pira, Ashley S; Febo, Marcelo

    2013-07-15

    Functional MRI in awake rats involves acclimatization to restraint to minimize motion. We designed a study to examine the effects of an acclimatization protocol (5 days of restraint, 60 min per day) on the emission of 22-kHz ultrasonic vocalizations and performance in a forced swim test (FST). Our results showed that USV calls are reduced significantly by days 3, 4 and 5 of acclimatization. Although the rats showed less climbing activity (and more immobility) in FST on day 5 compared to the 1st day of restraint acclimatization, the difference was not detected once the animals were given a 2-week hiatus. Overall, we showed that animals adapt to the restraint over a five-day period; however, restraint may introduce confounding behavioral outcomes that may hinder the interpretation of results derived from awake rat imaging. The present data warrants further testing of the effects of MRI restraint on behavior. PMID:23562621

  20. Short-term effects of an educational intervention on physical restraint use: a cluster randomized trial

    OpenAIRE

    Gulpers Math JM; Hamers Jan PH; Huizing Anna R; Berger Martijn PF

    2006-01-01

    Abstract Background Physical restraints are still frequently used in nursing home residents despite growing evidence for the ineffectiveness and negative consequences of these methods. Therefore, reduction in the use of physical restraints in psycho-geriatric nursing home residents is very important. The aim of this study was to investigate the short-term effects of an educational intervention on the use of physical restraints in psycho-geriatric nursing home residents. Methods A cluster rand...

  1. The effects of sex and hormonal status on restraint-stress-induced working memory impairment

    OpenAIRE

    Brennan Avis; Rubinow Katya; Shansky Rebecca M; Arnsten Amy FT

    2006-01-01

    Abstract Background Restraint stress has been shown to elicit numerous effects on hippocampal function and neuronal morphology, as well as to induce dendritic remodeling in the prefrontal cortex (PFC). However, the effects of acute restraint stress on PFC cognitive function have not been investigated, despite substantial evidence that the PFC malfunctions in many stress-related disorders. Methods The present study examined the effects of restraint stress on PFC function in both male rats and ...

  2. Overview of core designs and requirements/criteria for core restraint systems

    International Nuclear Information System (INIS)

    The requirements and lifetime criteria for the design of a Liquid Metal Fast Breeder Reactor (LMFBR) Core Restraint System are presented. A discussion of the three types of core restraint systems used in LMFBR core design is given. Details of the core restraint system selected for FFTF are presented and the reasons for this selection given. Structural analysis procedures being used to manage the FFTF assembly irradiations are discussed. Efforts that are ongoing to validate the calculational methods and lifetime criteria are presented

  3. Dietary restraint and self-discrepancy in male university students.

    Science.gov (United States)

    Orellana, Ligia; Grunert, Klaus G; Sepúlveda, José; Lobos, Germán; Denegri, Marianela; Miranda, Horacio; Adasme-Berríos, Cristian; Mora, Marcos; Etchebarne, Soledad; Salinas-Oñate, Natalia; Schnettler, Berta

    2016-04-01

    Self-discrepancy describes the distance between an ideal and the actual self. Research suggests that self-discrepancy and dietary restraint are related, causing a significant impact on the person's well-being. However, this relationship has been mostly reported in female and mixed populations. In order to further explore dietary behaviors and their relations to self-discrepancy and well-being-related variables in men, a survey was applied to a non-probabilistic sample of 119 male students from five Chilean state universities (mean age=21.8, SD=2.75). The questionnaire included the Revised Restraint Scale (RRS) with the subscales weight fluctuations (WF) and diet concern (DC), the Satisfaction with Life Scale (SWLS), the Satisfaction with Food-Related Life Scale (SWFL), the Nutrition Interest Scale (NIS), and the Self-discrepancy Index (SDI). Questions were asked about socio-demographic characteristics, eating and drinking habits, and approximate weight and height. A cluster analysis applied to the Z-scores of the RRS classified the following typologies: Group 1 (22.7%), men concerned about weight fluctuations; Group 2 (37.0%), men concerned about diet and weight fluctuations; Group 3 (40.3%), unconcerned about diet and weight fluctuations. The typologies differed in their SDI score, restriction on pastry consumption and reported body mass index (BMI). Students with higher DC and WF scores had a higher BMI, and tended to report high self-discrepancy not only on a physical level, but also on social, emotional, economic and personal levels. This study contributes to the literature on subjective well-being, dietary restraint and self-discrepancy in men from non-clinical samples. PMID:26835591

  4. Influence of dosage and chemical restraints on feline excretory urography

    OpenAIRE

    R.A. Ajadi; Adetunji, A.; V.O. Omoerah; J.U. Okoh

    2006-01-01

    Three series of trials involving 10 domestic short-haired cats were carried out to determine the influence of dosage of contrast media or type of chemical restraint on feline excretory urography. The 1st series (group A) involved 5 cats sedated with 2.0 mg/kg intramuscular (i.m) injection of 2 % xylazine and receiving 800 mg/kg of 76 % meglumine diatrizoate (urografin). The 2nd series (group B) involved another 5 cats sedated with 2.0 mg/kg (i.m) injection of 2 % xylazine and receiving 1200 m...

  5. Design and optimization for the occupant restraint system of vehicle based on a single freedom model

    Science.gov (United States)

    Zhang, Junyuan; Ma, Yue; Chen, Chao; Zhang, Yan

    2013-05-01

    Throughout the vehicle crash event, the interactions between vehicle, occupant, restraint system (VOR) are complicated and highly non-linear. CAE and physical tests are the most widely used in vehicle passive safety development, but they can only be done with the detailed 3D model or physical samples. Often some design errors and imperfections are difficult to correct at that time, and a large amount of time will be needed. A restraint system concept design approach which based on single-degree-of-freedom occupant-vehicle model (SDOF) is proposed in this paper. The interactions between the restraint system parameters and the occupant responses in a crash are studied from the view of mechanics and energy. The discrete input and the iterative algorithm method are applied to the SDOF model to get the occupant responses quickly for arbitrary excitations (impact pulse) by MATLAB. By studying the relationships between the ridedown efficiency, the restraint stiffness, and the occupant response, the design principle of the restraint stiffness aiming to reduce occupant injury level during conceptual design is represented. Higher ridedown efficiency means more occupant energy absorbed by the vehicle, but the research result shows that higher ridedown efficiency does not mean lower occupant injury level. A proper restraint system design principle depends on two aspects. On one hand, the restraint system should lead to as high ridedown efficiency as possible, and at the same time, the restraint system should maximize use of the survival space to reduce the occupant deceleration level. As an example, an optimization of a passenger vehicle restraint system is designed by the concept design method above, and the final results are validated by MADYMO, which is the most widely used software in restraint system design, and the sled test. Consequently, a guideline and method for the occupant restraint system concept design is established in this paper.

  6. Evaluation of Multi Canister Overpack (MCO) Handling Machine Uplift Restraint for a Seismic Event During Repositioning Operations

    Energy Technology Data Exchange (ETDEWEB)

    SWENSON, C.E.

    2000-05-15

    Insertion of the Multi-Canister Overpack (MCO) assemblies into the Canister Storage Building (CSB) storage tubes involves the use of the MCO Handling Machine (MHM). During MCO storage tube insertion operations, inadvertent movement of the MHM is prevented by engaging seismic restraints (''active restraints'') located adjacent to both the bridge and trolley wheels. During MHM repositioning operations, the active restraints are not engaged. When the active seismic restraints are not engaged, the only functioning seismic restraints are non-engageable (''passive'') wheel uplift restraints which function only if the wheel uplift is sufficient to close the nominal 0.5-inch gap at the uplift restraint interface. The MHM was designed and analyzed in accordance with ASME NOG-1-1995. The ALSTHOM seismic analysis reported seismic loads on the MHM uplift restraints and EDERER performed corresponding structural calculations to demonstrate structural adequacy of the seismic uplift restraint hardware. The ALSTHOM and EDERER calculations were performed for a parked MHM with the active seismic restraints engaged, resulting in uplift restraint loading only in the vertical direction. In support of development of the CSB Safety Analysis Report (SAR), an evaluation of the MHM seismic response was requested for the case where the active seismic restraints are not engaged. If a seismic event occurs during MHM repositioning operations, a moving contact at a seismic uplift restraint would introduce a friction load on the restraint in the direction of the movement. These potential horizontal friction loads on the uplift restraints were not included in the existing restraint hardware design calculations. One of the purposes of the current evaluation is to address the structural adequacy of the MHM seismic uplift restraints with the addition of the horizontal friction associated with MHM repositioning movements.

  7. Carrying Capacity

    DEFF Research Database (Denmark)

    Schroll, Henning; Andersen, Jan; Kjærgård, Bente

    2012-01-01

    carrying capacity (SCC) and assimilative carrying capacity (ACC). The act mandates that the latter two aspects must be taken into consideration in the local spatial plans. The present study aimed at developing a background for a national guideline for carrying capacity in Indonesian provinces and districts...... carrying capacity (ACC). The act mandates that the latter two aspects must be taken into consideration in the local spatial plans. The present study aimed at developing a background for a national guideline for carrying capacity in Indonesian provinces and districts/cities. Four different sectors (water...

  8. Automated Design of Restraint Layer of an Inflatable Vessel

    Science.gov (United States)

    Spexarth, Gary

    2007-01-01

    A Mathcad computer program largely automates the design and analysis of the restraint layer (the primary load-bearing layer) of an inflatable vessel that consists of one or more sections having cylindrical, toroidal, and/or spherical shape(s). A restraint layer typically comprises webbing in the form of multiple straps. The design task includes choosing indexing locations along the straps, computing the load at every location in each strap, computing the resulting stretch at each location, and computing the amount of undersizing required of each strap so that, once the vessel is inflated and the straps thus stretched, the vessel can be expected to assume the desired shape. Prior to the development of this program, the design task was performed by use of a difficult-to-use spreadsheet program that required manual addition of rows and columns depending on the numbers of strap rows and columns of a given design. In contrast, this program is completely parametric and includes logic that automatically adds or deletes rows and columns as needed. With minimal input from the user, this program automatically computes indexing locations, strap lengths, undersizing requirements, and all design data required to produce detailed drawings and assembly procedures. It also generates textual comments that help the user understand the calculations.

  9. Comparison of chemical restraint techniques in ostrich (Struthio camelus

    Directory of Open Access Journals (Sweden)

    R Ciboto

    2006-06-01

    Full Text Available Chemical restraint in ostriches is usually required for short-time interventions. Thus, this study established and evaluated intravenous anesthetics formulated from commonly used drugs in order to accomplish total restraint on this species and allow painful procedures to be performed. Thirty male and female ostriches weighing from 40 to 90 kg were randomly distributed into five groups. Animals in Groups I, II and III were given acepromazine (0.25 mg/kg i.m. and those in Groups IV and V were given xylazine (1.0 mg/kg i.m.. The following drugs were administered intravenously 15 to 20 min later: Group I - propofol (4.0 mg/kg, Groups II and IV - ketamine (5.0 mg/kg and diazepam (0.25 mg/kg, Groups III and V - tiletamine-zolazepam (3.0 mg/kg. All protocols have produced satisfactory results regarding total containment, muscular relaxation and maintenance of the evaluated parameters within a normal range.

  10. Influence of Polymer Restraint on Ballistic Performanceof Alumina Ceramic Tiles

    Directory of Open Access Journals (Sweden)

    P.R.S. Reddy

    2008-03-01

    Full Text Available An experimental study has been carried out to evaluate the influence of confinement ofalumina ceramic tiles through polymer restraint, on its ballistic performance. Tiles of 99.5 per centpurity alumina were subjected to ballistic impact against 7.62 mm armour piercing projectiles atvelocities of about 820 m/s. The tiles of size 75 mm x 75 mm x 7 mm were confined on both facesby effectively bonding varying numbers of layers of polymer fabrics. These were then bondedto a 10 mm thick fibre glass laminate as a backing using epoxy resin. High performance polyethyleneand aramid polymer fabrics were used in the current set of experiments for restraining the tiles.Comparative effects of confinement on energy absorption of tiles with varied number of layersof fabrics were evaluated. It was observed that by providing effective confinement to the tile,energy absorption could be doubled with increase in areal density by about 13 per cent.Photographs of the damage and the effects of restraint on improvement in energy absorptionof ceramic tiles are presented and discussed.

  11. Are Dietary Restraint Scales Valid Measures of Acute Dietary Restriction? Unobtrusive Observational Data Suggest Not

    Science.gov (United States)

    Stice, Eric; Fisher, Melissa; Lowe, Michael R.

    2004-01-01

    The finding that dietary restraint scales predict onset of bulimic pathology has been interpreted as suggesting that dieting causes this eating disturbance, despite the dearth of evidence that these scales are valid measures of dietary restriction. The authors conducted 4 studies that tested whether dietary restraint scales were inversely…

  12. 49 CFR 571.225 - Standard No. 225; Child restraint anchorage systems.

    Science.gov (United States)

    2010-10-01

    ...) and (b) of S7 apply to the test procedures in S8. (a) Vehicle seats are adjusted to their full... systems. S1. Purpose and scope. This standard establishes requirements for child restraint anchorage... buses, and funeral coaches. S3. Definitions. Child restraint anchorage means any vehicle...

  13. Prior Restraint in High School: Does It Violate Students' First Amendment Rights?

    Science.gov (United States)

    Trager, Robert E.

    The Supreme Court of the United States has issued three significant rulings on the question of prior restraint by government officials of material to be published in print media. Each time it ruled that only in exceptional circumstances will prior restraint be permitted. Lower federal courst have not taken the same view regarding prior restraint…

  14. Peer Drug Associations and Emotional Restraint: Causes or Consequences of Adolescents' Drug Use?

    Science.gov (United States)

    Farrell, Albert D.; Danish, Steven J.

    1993-01-01

    Used three-wave longitudinal design to examine relationships among emotional restraint, peer drug associations, and gateway drug use among 1,256 middle school students. In reciprocal model, low emotional restraint was significantly related to subsequent increases in gateway drug use among boys. In contrast, peer drug models and peer pressure were…

  15. Short-term effects of an educational intervention on physical restraint use: a cluster randomized trial

    Directory of Open Access Journals (Sweden)

    Gulpers Math JM

    2006-10-01

    Full Text Available Abstract Background Physical restraints are still frequently used in nursing home residents despite growing evidence for the ineffectiveness and negative consequences of these methods. Therefore, reduction in the use of physical restraints in psycho-geriatric nursing home residents is very important. The aim of this study was to investigate the short-term effects of an educational intervention on the use of physical restraints in psycho-geriatric nursing home residents. Methods A cluster randomized trial was applied to 5 psycho-geriatric nursing home wards (n = 167 residents with dementia. The wards were assigned at random to either educational intervention (3 wards or control status (2 wards. The restraint status was observed and residents' characteristics, such as cognitive status, were determined by using the Minimum Data Set (MDS at baseline and 1 month after intervention. Results Restraint use did not change significantly over time in the experimental group (55%–56%, compared to a significant increased use (P Conclusion An educational programme for nurses combined with consultation with a nurse specialist did not decrease the use of physical restraints in psycho-geriatric nursing home residents in the short term. However, the residents in the control group experienced more restraint use during the study period compared to the residents in the experimental group. Whether the intervention will reduce restraint use in the long term could not be inferred from these results. Further research is necessary to gain insight into the long-term effects of this educational intervention.

  16. Angiotensin-converting enzyme inhibition increases glucose-induced insulin secretion in response to acute restraint.

    Science.gov (United States)

    Schweizer, Júnia R O L; Miranda, Paulo A C; Fóscolo, Rodrigo B; Lemos, Joao P M; Paula, Luciano F; Silveira, Warley C; Santos, Robson A S; Pinheiro, Sérgio V B; Coimbra, Candido C; Ribeiro-Oliveira, Antônio

    2012-12-01

    There is increasing evidence suggesting involvement of the renin-angiotensin system (RAS) in carbohydrate metabolism and its response to stress. Thus, the aim of the present study was to evaluate the effects of chronic inhibition of the RAS on glucose and insulin levels during acute restraint stress. Male Holtzman rats were treated with 10 mg/kg per day enalapril solution or vehicle for 14 days. After 14 days, rats were divided into three experimental groups: enalapril + restraint (ER), vehicle + restraint (VR) and enalapril + saline (ES). Rats in the restraint groups were subjected to 30 min restraint stress, whereas rats in the ES groups were given saline infusion instead. Blood samples were collected at baseline and after 5, 10, 20 and 30 min restraint stress or saline infusion. After restraint, a hyperglycaemic response was observed in the ER and VR groups that peaked at 20 and 10 min, respectively (P inhibition with enalapril may increase glucose-induced insulin secretion in response to acute restraint. PMID:23734984

  17. Effect of restraint of pressure induced bending on leakage-size-crack in LBB evaluation

    International Nuclear Information System (INIS)

    In order to evaluate the effect of restraint of Pressure Induced Bending(PIB) on leakage-size-crack in LBB evaluation, this study calculated Crack Mouth Opening Displacement (CMOD) for circumferential through-wall crack in pipe by using both elastic and elastic-plastic finite element analyses. The analyses results showed the restraint of PIB was decreased crack opening for a given crack size and tensile stress, and the effect was considerable for large crack and short restraint length. Also, the restraint effect of CMOD was independent on the variation in pipe diameter and decreased with increasing pipe thickness, and it depended on not total restraint length but a restraint length near the crack for non-symmetrically restrained condition. Additionally, the effect of restraint of PIB was more significant in the results of elastic-plastic analysis compared with that of elastic analysis. On the other hand, the estimation of the PIB restraint effect on the pipes which have been appled LBB showed that the effect on the LBB application is negligible in these pipes

  18. Evaluation of restraint system concepts for the Japanese Experiment Module flight demonstration

    Science.gov (United States)

    Sampaio, Carlos E.; Fleming, Terence F.; Stuart, Mark A.; Backemeyer, Lynn A.

    1995-01-01

    The current International Space Station configuration includes a Japanese Experiment Module which relies on a large manipulator and a smaller dexterous manipulator to operate outside the pressurized environment of the experiment module. The module's flight demonstration is a payload that will be mounted in the aft flight deck on STS-87 to evaluate a prototype of the dexterous manipulator. Since the payload operations entail two 8-hour scenarios on consecutive days, adequate operator restraint at the workstation will be critical to the perceived success or failure of the payload. Simulations in reduced gravity environment on the KC-135A were the only way to evaluate the restraint systems and workstation configuration. Two astronaut and two non-astronaut operators evaluated the Advanced Lower Body Extremities Restraint Test and a foot loop restraint system by performing representative tasks at the workstation in each of the two restraint systems; at the end of each flight they gave their impressions of each system and the workstation. Results indicated that access to the workstation switch panels was difficult and manipulation of the hand controllers forced operators too low for optimal viewing of the aft flight deck monitors. The workstation panel should be angled for better visibility, and infrequently used switches should be on the aft flight deck panel. Pitch angle and placement of the hand controllers should optimize the operator's eye position with respect to the monitors. The lower body restraint was preferred over the foot loops because it allowed operators to maintain a more relaxed posture during long-duration tasks, its height adjustability allowed better viewing of aft flight deck monitors, and it provided better restraint for reacting forces imparted on the operator at the workstation. The foot loops provide adequate restraint for the flight demonstration tasks identified. Since results will impact the design of the workstation, both restraints should be

  19. Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats

    Directory of Open Access Journals (Sweden)

    Merhan Ragy

    2016-01-01

    Full Text Available In the brain, the heme oxygenase (HO system has been reported to be very active and its modulation seems to play a crucial role in the pathophysiology of neurodegenerative disorders. Hemin as HO-1 inducer has been shown to attenuate neuronal injury so the goal of this study was to assess the effect of hemin therapy on the acute stress and how it would modulate neurological outcome. Thirty male albino rats were divided into three groups: control group and stressed group with six-hour water immersion restraint stress (WIRS and stressed group, treated with hemin, in which each rat received a single intraperitoneal injection of hemin at a dose level of 50 mg/kg body weight at 12 hours before exposure to WIRS. Stress hormones, oxidative stress markers, malondialdehyde (MDA, and total antioxidant capacity (TAC were measured and expressions of neuroglobin and S100B mRNA in brain tissue were assayed. Our results revealed that hemin significantly affects brain alterations induced by acute stress and this may be through increased expression of neuroglobin and through antioxidant effect. Hemin decreased blood-brain barrier damage as it significantly decreased the expression of S100B. These results suggest that hemin may be an effective therapy for being neuroprotective against acute stress.

  20. Different subtypes of impulsivity differentiate uncontrolled eating and dietary restraint.

    Science.gov (United States)

    Leitch, Margaret A; Morgan, Michael J; Yeomans, Martin R

    2013-10-01

    The current study explored the relationship between three subtypes of impulsivity (Reflection Impulsivity, Impulsive Choice, and Impulsive Action) and measures of uncontrolled eating (TFEQ-D) and restraint (TFEQ-R). Eighty women classified as scoring higher or lower on TFEQ-D and TFEQ-R completed the Matching Familiar Figures Test (MFFT20), Delay Discounting Task (DDT), a Go No Go task, Balloon Analogue Risk Task (BART), and the Barrett Impulsivity Scale-11 (BIS-11). To test whether these relationships were affected by enforced controls overeating, half of the participants fasted the night before and ate breakfast in the laboratory before testing and half had no such control. Women scoring higher on the TFEQ-D were significantly more impulsive on the MFFT20 and BIS-11 overall but not on DDT, Go No Go or BART. Women scoring higher on TFEQ-R were significantly less impulsive on the Go No Go task but did not differ on other measures. The eating manipulation modulated responses on the BART and BIS-11 non-planning scale depending on TFEQ-D classification. These results confirm recent data that high scores on TFEQ-D are related to impulsivity, but imply this relates more to Reflection Impulsivity rather than Impulsive Choice or Action. In contrast restrained eating was associated with better inhibitory control. Taken together, these results suggest that subtypes of impulsivity further differentiate uncontrolled eating and restraint, and suggest that a poor ability to reflect on decisions may underlie some aspects of overeating. PMID:23702263

  1. Restraint use in home care: a qualitative study from a nursing perspective

    Science.gov (United States)

    2014-01-01

    Background Despite the growing demand for home care and preliminary evidence suggesting that the use of restraint is common practice in home care, research about restraint use in this setting is scarce. Methods To gain insight into the use of restraints in home care from the perspective of nurses, we conducted a qualitative explorative study. We conducted semi-structured face-to-face interviews of 14 nurses from Wit-Gele Kruis, a home-care organization in Flanders, Belgium. Interview transcripts were analyzed using the Qualitative Analysis Guide of Leuven. Results Our findings revealed a lack of clarity among nurses about the concept of restraint in home care. Nurses reported that cognitively impaired older persons, who sometimes lived alone, were restrained or locked up without continuous follow-up. The interviews indicated that the patient’s family played a dominant role in the decision to use restraints. Reasons for using restraints included “providing relief to the family” and “keeping the patient at home as long as possible to avoid admission to a nursing home.” The nurses stated that general practitioners had no clear role in deciding whether to use restraints. Conclusions These findings suggest that the issue of restraint use in home care is even more complex than in long-term residential care settings and acute hospital settings. They raise questions about the ethical and legal responsibilities of home-care providers, nurses, and general practitioners. There is an urgent need for further research to carefully document the use of restraints in home care and to better understand it so that appropriate guidance can be provided to healthcare workers. PMID:24498859

  2. CLASSIFICATION OF RESTRAINTS IN THE OPTIMIZATION PROBLEM OF A COLD-FORMED PROFILE

    Directory of Open Access Journals (Sweden)

    Agnieszka Łukowicz

    2015-11-01

    Full Text Available This work describes the restraints in the optimization problem. This is an important and complicated issue because it requires taking into account a vast range of information related to the design and production. In order to describe the relations of a specific optimization problem, it is essential to adopt appropriate criteria and to collect information on all kinds of restraints, i.e. boundary conditions. The following paper verifies the various restraints and defines three subsets: design assumptions, technological limitations and standard conditions. The provided classification was made with reference to the analysis of the construction applicability of the newly patented cold-formed profile.

  3. Dietary Restraint Partially Mediates the Relationship between Impulsivity and Binge Eating Only in Lean Individuals: The Importance of Accounting for Body Mass in Studies of Restraint

    Science.gov (United States)

    Coffino, Jaime A.; Orloff, Natalia C.; Hormes, Julia M.

    2016-01-01

    Binge eating is characteristic of eating and weight-related disorders such as binge eating disorder, bulimia nervosa, and obesity. In light of data suggest impulsivity is associated with overeating specifically in restrained eaters, this study sought to elucidate the exact nature of the associations between these variables, hypothesizing that the relationship between impulsivity and binge eating is mediated by restrained eating. We further hypothesized that the role of dietary restraint as a mediator would be moderated by body mass index (BMI). Study participants (n = 506, 50.6% female) were categorized based on self-reported BMI as under- and normal-weight (BMI Emotion Regulation Scale, and the Binge Eating Scale. Findings provide initial evidence for the hypothesized moderated mediation model, with dietary restraint partially mediating the relationship between impulsivity and binge eating severity only in lean respondents. In respondents with overweight or obesity, impulsivity was significantly correlated with binge eating severity, but not with dietary restraint. Findings inform our conceptualization of dietary restraint as a possible risk factor for binge eating and highlight the importance of accounting for body mass in research on the impact of dietary restraint on eating behaviors. PMID:27757092

  4. Effect of "Ginseng" administration on the structural and ultrastructural changes produced by restraint stress in theultrastructural changes produced by restraint stress in the

    Directory of Open Access Journals (Sweden)

    Mona A.R. Salem

    2001-06-01

    Full Text Available This study aimed to assess the antistress effects of "Ginseng" in cases of chronic restraint stress by studying the structural and ultrastructural changes of the liver cells. Fifteen adult male albino rats were used. They were divided equally into 3 groups: control, stress and stress/Ginseng groups. Restraint stress was applied to both stress and stress/Ginseng groups 4 hours every other day for 4 weeks.15 mg Ginseng/kg/ was given to stress /Ginseng group every other day for 4weeks. Examination of liver specimens processed for both light and electron microscopic study revealed that chronic restraint stress causes fatty degeneration which may proceed to necrosis of the liver cells. A hepatoprotectective effect of ginseng was observed.

  5. Effect of Restraint Stress during Gestation on Pentylenetetrazol-Induced Epileptic Behaviors in Rat Offspring

    Directory of Open Access Journals (Sweden)

    Pariya Hashemi

    2013-09-01

    Prenatal restraint stress potentiated PTZ-induced epileptic behavior, age and sex dependently, probably due to alteration of neural and endocrine pathways during developmental process. Male and younger rats were more sensitive to stress than female and older ones.

  6. Depressed affect and dietary restraint in adolescent boys' and girls' eating in the absence of hunger.

    Science.gov (United States)

    Kelly, Nichole R; Shomaker, Lauren B; Pickworth, Courtney K; Grygorenko, Mariya V; Radin, Rachel M; Vannucci, Anna; Shank, Lisa M; Brady, Sheila M; Courville, Amber B; Tanofsky-Kraff, Marian; Yanovski, Jack A

    2015-08-01

    Data suggest that depressed affect and dietary restraint are related to disinhibited eating patterns in children and adults. Yet, experimental research has not determined to what extent depressed affect acutely affects eating in the absence of physiological hunger (EAH) in adolescents. In the current between-subjects experimental study, we measured EAH in 182 adolescent (13-17 y) girls (65%) and boys as ad libitum palatable snack food intake after youth ate to satiety from a buffet meal. Just prior to EAH, participants were randomly assigned to view either a sad or neutral film clip. Dietary restraint was measured with the Eating Disorder Examination. Adolescents who viewed the sad film clip reported small but significant increases in state depressed affect relative to adolescents who viewed the neutral film clip (p affective state and dietary restraint, is required to elucidate how state affect may interact with dietary restraint to influence EAH during adolescence. PMID:25936291

  7. Evaluation of the influence of seismic restraint characteristics on LMFBR piping

    Energy Technology Data Exchange (ETDEWEB)

    Mallett, R.H.

    1979-01-01

    For the Clinch River Breeder Reactor Plant (CRBRP) heat transport system piping within the reactor containment building, dynamic analyses of the piping loops have been performed to study the effect of restraint stiffness on the dynamic behavior of the piping, i.e., changes in frequencies, mode shapes, loads, stresses, and displacements. In addition, analysis and testing of typical CRBRP restraint system components have been performed for the purpose of quantifying and verifying the basic characteristics of the restraints used in the piping system dynamic analysis. The results are presented of the analysis and testing described above. In particular, it is shown that piping restraint effects on breeder reactor piping response are important considerations in the design/analysis process.

  8. Treatment of Self-restraint Associated With The Application of Protective Equipment

    OpenAIRE

    Powers, Katherine V; Roane, Henry S; Kelley, Michael E

    2007-01-01

    The current investigation assessed the effectiveness of protective equipment, specifically arm splints, in reducing the occurrence of severe self-injurious behavior (SIB). Although the protective equipment reduced rates of SIB to near-zero levels, self-restraint subsequently emerged. In an attempt to reduce self-restraint while maintaining reductions in SIB, we provided noncontingent access to preferred stimuli. The presentation of preferred stimuli along with the use of protective equipment ...

  9. Pipe whip restraints - protection for safety related equipment of WWER nuclear power plants

    International Nuclear Information System (INIS)

    The paper concerns the problem of enhancing the protection of WWER NPP equipment against the effect of a high energy piping break which results in a pipe whip. A pipe whip restraint has been designed in order to protect nearby safety related systems and components. The pipe whip restraint properties have been optimized using results of iterative non-linear dynamic analyses of the piping system response to forces due to fluid streaming out of the broken pipe. (author)

  10. Succeeding in Sustained Reduction in the use of Restraint using the Improvement Model.

    Science.gov (United States)

    Bell, Alyssa; Gallacher, Neil

    2016-01-01

    As part of the Scottish Patient Safety Programme - Mental Health one of the main drivers was the reduction of harm to patients caused by restraint. The aim of this project was to reduce the number of restraints on our Acute Admissions ward. Through use the of the Improvement Model (PDSA), frontline staff were empowered to implement small tests of change at a grassroots level. This approach has led to frontline staff having ownership of driving the changes on a daily basis within the Clinical area. The use of a restraint data collection tool has been adapted and developed with frontline staff to ensure that the staff have ownership of data collected and is used to facilitate improvement. This data is used to inform the development of our Physical Interventions training. Most recently, following analysis, were able to introduce changes to promote the increased use of de-escalation and a shift from prone restraint to the safer seated restraint position. Patient involvement has been paramount with their inclusion in the debrief process. The information gleaned from the patients is used for staff and patient reflection. This has created a learning environment not only for staff but also patients and carers. Everyone involved is able to identify reasons and triggers and generate ideas to reduce the possibility of another restraint. The use of staff and patient safety climate surveys has ensured that we are constantly monitoring improvements in the feeling of safety amongst staff and patients. Our approach has resulted in a change in the culture of restraint resulting in a sustained reduction of 50% in restraint. PMID:27335641

  11. Stigma and Management on People with Severe Mental Disorders with “Pasung” (Physical restraint)

    OpenAIRE

    Weny Lestari

    2015-01-01

    background: Mental disorders remain serious mental health problems in Indonesia. In 2007 there were 0,46 percent of the total population in Indonesia had high risk of schizophrenia. There are many people with severe mental disorders who do not receive medical treatment or dropped out from medical treatment and then put in physical restraint. Methods:The analysis was based on previous study on the elimination program for physical restraints in 2011. The methods were by collecting news, researc...

  12. RELATIONSHIP BETWEEN PARENTAL RESTRAINTS, EMOTIONAL INTELLIGENCE AND ACADEMIC ACHIEVEMENT AMONG RURAL HIGH SCHOOL GIRLS

    OpenAIRE

    Sushma H.B; Surekha Ksheerasagar

    2014-01-01

    This study investigated the relationship among parental restraints on emotional intelligence and academic achievement of 60 high school going pre-adolescent girls (30 Kannada Medium and 30 English Medium) of rural areas of Gulbarga district. The participants ranged in age between 11 to 17years. Two hypotheses were tested for significance at 0.05 margin in error. The main objective of the study is to find the relationship between parental restraints on emotional intelligence an...

  13. [The objectives of the reform of hospitalisation under restraint in psychiatry].

    Science.gov (United States)

    Ledesma, Enrique

    2012-01-01

    The law of July 5th, 2011 reforms legislation dating from June 27th, 1990. It adds elements identified as missing from the original text over the course of the years following its application. The systematic intervention of a liberties and detention judge could counterbalance the measures simplifying hospitalisation under restraint. Stricter monitoring of "unwieldy" patients is also included in measures which enable treatment under restraint to be given through outpatient care.

  14. EU competition policy, vertical restraints, and innovation: an analysis from an evolutionary perspective

    OpenAIRE

    Kerber, Wolfgang; Vezzoso, Simonetta

    2004-01-01

    The EU competition policy in regard to vertical restraints is mainly based upon neoclassical efficiency-oriented reasonings, leading to a neglect of the innovation dimension. This paper analyses to what extent evolutionary theories of competition and innovation economics can be used to derive additional, new criteria for the assessment of vertical restraints. It is shown that Neo- Schumpeterian and Hayekian approaches to competition and innovation economics as well as knowledge-based theories...

  15. DEFINING SECLUSION AND RESTRAINT: LEGAL AND POLICY DEFINITIONS VERSUS CONSUMER AND CARER PERSPECTIVES.

    Science.gov (United States)

    Roper, Cath; McSherry, Bernadette; Brophy, Lisa

    2015-12-01

    The practices of seclusion and restraint may be used in a variety of health settings to control behaviour. Laws and policies that seek to regulate these practices define seclusion and restraint in various ways and there are gaps as to which practices are regulated and in what circumstances. This column provides an overview of consumer and carer perspectives as to what is meant by these practices.

  16. Mixed selection. Effects of body images, dietary restraint, and persuasive messages on females' orientations towards chocolate.

    Science.gov (United States)

    Durkin, Kevin; Hendry, Alana; Stritzke, Werner G K

    2013-01-01

    Many women experience ambivalent reactions to chocolate: craving it but also wary of its impact on weight and health. Chocolate advertisements often use thin ideal models and previous research indicates that this exacerbates ambivalence. This experiment compared attitudes to, and consumption of, chocolate following exposure to images containing thin or overweight models together with written messages that were either positive or negative about eating chocolate. Participants (all female) were categorised as either low- or high-restraint. Approach, avoidance and guilt motives towards chocolate were measured and the participants had an opportunity to consume chocolate. Exposure to thin ideal models led to higher approach motives and this effect was most marked among the high restraint participants. Avoidance and guilt scores did not vary as a function of model size or message, but there were clear differences between the restraint groups, with the high restraint participants scoring substantially higher than low restraint participants on both of these measures. When the participants were provided with an opportunity to eat some chocolate, those with high restraint who had been exposed to the thin models consumed the most. PMID:23032304

  17. Validation of a new restraint docking method for solution structure determinations of protein-ligand complexes

    Energy Technology Data Exchange (ETDEWEB)

    Polshakov, Vladimir I.; Morgan, William D.; Birdsall, Berry; Feeney, James [National Institute for Medical Research, Division of Molecular Structure (United Kingdom)

    1999-06-15

    A new method is proposed for docking ligands into proteins in cases where an NMR-determined solution structure of a related complex is available. The method uses a set of experimentally determined values for protein-ligand, ligand-ligand, and protein-protein restraints for residues in or near to the binding site, combined with a set of protein-protein restraints involving all the other residues which is taken from the list of restraints previously used to generate the reference structure of a related complex. This approach differs from ordinary docking methods where the calculation uses fixed atomic coordinates from the reference structure rather than the restraints used to determine the reference structure. The binding site residues influenced by replacing the reference ligand by the new ligand were determined by monitoring differences in {sup 1}H chemical shifts. The method has been validated by showing the excellent agreement between structures of L. casei dihydrofolate reductase.trimetrexate calculated by conventional methods using a full experimentally determined set of restraints and those using this new restraint docking method based on an L. casei dihydrofolate reductase.methotrexate reference structure.

  18. A bitter sweet asynchrony. The relation between eating attitudes, dietary restraint on smell and taste function.

    Science.gov (United States)

    Stafford, Lorenzo D; Tucker, Megan; Gerstner, Nora

    2013-11-01

    Research has demonstrated that individuals with eating disorders have an impaired sense of smell and taste, though the influence of eating attitudes, dietary restraint and gender in a non-clinical sample is unknown. In two studies (study 1: 32 females, 28 males; study 2: 29 females) participants completed questionnaires relating to Eating Attitudes (EAT) and dietary restraint (DEBQ) followed by an odour (study 1: isoamyl acetate, study 2: chocolate) threshold and taste test. In study 2 we also measured the number of fungiform papillae taste buds. Study one revealed that increases in pathological eating attitudes predicted poorer olfactory sensitivity (males/females) and lower bitterness ratings for the bitter tastant (females only), suggestive of poorer taste acuity. In study two we found that both eating attitudes and restraint predicted poorer sensitivity to an odour associated to a forbidden food (chocolate) and that increasing eating attitudes predicted higher sweetness ratings for the bitter tastant. Interestingly increases in restraint were associated with an increased number of fungiform papillae which was not related to bitter or sweet intensity. These findings demonstrate that in a young healthy sample that subtle differences in eating pathology and dietary restraint predict impaired olfactory function to food related odours. Further that perception of bitter tastants is poorer with changes in eating pathology but not dietary restraint.

  19. Rappertk: a versatile engine for discrete restraint-based conformational sampling of macromolecules

    Directory of Open Access Journals (Sweden)

    Karmali Anjum M

    2007-03-01

    Full Text Available Abstract Background Macromolecular structures are modeled by conformational optimization within experimental and knowledge-based restraints. Discrete restraint-based sampling generates high-quality structures within these restraints and facilitates further refinement in a continuous all-atom energy landscape. This approach has been used successfully for protein loop modeling, comparative modeling and electron density fitting in X-ray crystallography. Results Here we present a software toolkit (Rappertk which generalizes discrete restraint-based sampling for use in structural biology. Modular design and multi-layered architecture enables Rappertk to sample conformations of any macromolecule at many levels of detail and within a variety of experimental restraints. Performance against a Cα-tracing benchmark shows that the efficiency has not suffered despite the overhead required by this flexibility. We demonstrate the toolkit's capabilities by building high-quality β-sheets and by introducing restraint-driven sampling. RNA sampling is demonstrated by rebuilding a protein-RNA interface. Ability to construct arbitrary ligands is used in sampling protein-ligand interfaces within electron density. Finally, secondary structure and shape information derived from EM are combined to generate multiple conformations of a protein consistent with the observed density. Conclusion Through its modular design and ease of use, Rappertk enables exploration of a wide variety of interesting avenues in structural biology. This toolkit, with illustrative examples, is freely available to academic users from http://www-cryst.bioc.cam.ac.uk/~swanand/mysite/rtk/index.html.

  20. Analytic Solution of Interaction Between Surface Waves and Floating Elastic Plates with Elastic End-Restraints

    Institute of Scientific and Technical Information of China (English)

    ZHAO Cun-bao; ZHANG Jia-zhong; XING Hai-yan; HUANG Wen-hu

    2007-01-01

    Based on the dynamic theories of water waves and Mindlin plates,the analytic solution of interaction between surface waves and two-dimensional floating elastic plates with edge-restraint is constructed by use of the Wiener-Hopf technique.Firstly,without regard for elastic edge restraint,the wave-induced responses of elastic floating plate analyzed by the present method are in good agreement with the results from literature and experimental results.Therefore,it can be shown that the present method is valid.Secondly,three end-restraint cases (i.e.,the left-end elastic restraints,the both-end elastic restraints,and the right-end elastic restraints) are proposed to reduce the vibration of floating plates,in which the spring is used to connect the sea bottom and the floating plate's left (or right) edge.The relations between the spring stiffness and the parameters of wave-induced responses of floating plates are discussed.Moreover,the effective method to reduce the vibration of floating elastic plates can be obtained through comparison.

  1. Extraction of distance restraints from pure shift NOE experiments

    Science.gov (United States)

    Kaltschnee, Lukas; Knoll, Kevin; Schmidts, Volker; Adams, Ralph W.; Nilsson, Mathias; Morris, Gareth A.; Thiele, Christina M.

    2016-10-01

    NMR techniques incorporating pure shift methods to improve signal resolution have recently attracted much attention, owing to their potential use in studies of increasingly complex molecular systems. Extraction of frequencies from these simplified spectra enables easier structure determination, but only a few of the methods presented provide structural parameters derived from signal integral measurements. In particular, for quantification of the nuclear Overhauser effect (NOE) it is highly desirable to utilize pure shift techniques where signal overlap normally prevents accurate signal integration, to enable measurement of a larger number of interatomic distances. However, robust methods for the measurement of interatomic distances using the recently developed pure shift techniques have not been reported to date. In this work we discuss some of the factors determining the accuracy of measurements of signal integrals in interferogram-based Zangger-Sterk (ZS) pure shift NMR experiments. The ZS broadband homodecoupling technique is used in different experiments designed for quantitative NOE determination from pure shift spectra. It is shown that the techniques studied can be used for quantitative extraction of NOE-derived distance restraints, as exemplified for the test case of strychnine.

  2. Anticipatory precrash restraint sensor feasibility study: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kercel, S.W.; Dress, W.B.

    1995-08-01

    This report explores feasibility of an anticipatory precrash restraint sensor. The foundation principle is the anticipation mechanism found at a primitive level of biological intelligence and originally formalized by the mathematical biologist Robert Rosen. A system based on formal anticipatory principles should significantly outperform conventional technologies. It offers the prospect of high payoff in prevention of death and injury. Sensors and processes are available to provide a good, fast, and inexpensive description of the present dynamical state of the vehicle to the embedded system model in the anticipation engine. The experimental part of this study found that inexpensive radar in a real-world setting does return useful data on target dynamics. The data produced by a radar system can be converted to target dynamical information by good, fast and inexpensive signal-processing techniques. Not only is the anticipatory sensor feasible, but further development under the sponsorship of the National Highway Traffic Safety Administration is necessary and desirable. There are a number of possible lines of follow-on investigation. The level of effort and expected benefits of various alternatives are discussed.

  3. Development of alternate visual examination requirements for dynamic restraints (snubbers)

    Energy Technology Data Exchange (ETDEWEB)

    Reich, M.; Breidenbach, G.; Grossman, W.

    1989-01-01

    Current plant technical specifications require an initial inservice visual examination of safety related equipment dynamic restraints (snubbers) to provide assurance of operability. The time to the next examination is as short as 1 month if 8 or more snubbers are found to be inoperable. Plant operators have observed that as the snubber population of a plant increases, the current plan becomes burdensome by requiring frequent shutdowns for examination of snubbers. The Nuclear Regulatory Commission (NRC) has recognized the need and has sponsored a program to develop alternate visual examination criteria which would require examinations at constant intervals such as at refueling outages. Brookhaven National Laboratories (BNL) was selected by the NRC to conduct this program. Based on the review and evaluation of the information gathered to date, and the conclusions drawn from plant visits and the Snubber Utility Group (SNUG) data base, BNL has developed an alternate statistically-based plan which provides the permissible number of inoperable snubbers for constant and twice constant visual examination intervals for various snubber population groups. 3 refs., 2 figs., 2 tabs.

  4. Effect of PCMI restraint on bubble size distribution in the rim structure of UO2 fuel

    International Nuclear Information System (INIS)

    Generally, the bubble size in the rim structure of UO2 is not dependent on the fuel burnup and the bubble pressure is higher than that in the equilibrium condition. However it was also observed that if the fuel pellet is not restrained, the size of the bubbles in the rim structure could be larger than that in the restraint condition. Although the wide variety of rim bubble sizes and porosities possibly result from an external restrain effect, the quantitative method to analyze the effect of PCMI restraint on bubble distribution in the rim is not available at the moment. In this paper, a method is developed which can be used to analyze the effect of PCMI restraint on the bubble distribution in the rim structure of UO2 fuel based on the data in the literatures. The total number of Xe atoms in the rim bubbles per unit rim volume could be derived by a summation of the number of Xe atoms of each rim bubble in a unit rim volume. The number of Xe atoms of each rim bubble could be calculated by the Van der Waals equation of state and the pressure expressed by p=σ+C/r, where C is an unknown constant to be determined as a function of the temperature and the burnup. On the other hand, the total number of Xe atoms in the rim bubbles per unit rim volume can also be calculated by Xe depression data. If the fuel pellet is not restrained, the uniform hydrostatic stress, σ is zero. Hence if the data of the fuel disk without a restraint is used, a constant C can be obtained at 823K and a local burnup of 90 GWd/t. Although the local burnup of PCMI restraint case is slightly different from that without PCMI restraint, the value derived above is used for the analysis of PCMI restraint case. The calculated bubble distribution with PCMI restraint was similar to the measured one. Because the effect of PCMI restraint on bubble size increased with the bubble size, the development of a large bubble was suppressed. Hence, the PCMI restraint caused a typical bubble size in the rim and

  5. Probing Capacity

    CERN Document Server

    Asnani, Himanshu; Weissman, Tsachy

    2010-01-01

    We consider the problem of optimal probing of states of a channel by transmitter and receiver for maximizing rate of reliable communication. The channel is discrete memoryless (DMC) with i.i.d. states. The encoder takes probing actions dependent on the message. It then uses the state information obtained from probing causally or non-causally to generate channel input symbols. The decoder may also take channel probing actions as a function of the observed channel output and use the channel state information thus acquired, along with the channel output, to estimate the message. We refer to the maximum achievable rate for reliable communication for such systems as the 'Probing Capacity'. We characterize this capacity when the encoder and decoder actions are cost constrained. To motivate the problem, we begin by characterizing the trade-off between the capacity and fraction of channel states the encoder is allowed to observe, while the decoder is aware of channel states. In this setting of 'to observe or not to o...

  6. Restraint Stress Intensifies Interstitial K+ Accumulation during Severe Hypoxia

    Science.gov (United States)

    Schnell, Christian; Janc, Oliwia A.; Kempkes, Belinda; Callis, Carolina Araya; Flügge, Gabriele; Hülsmann, Swen; Müller, Michael

    2012-01-01

    Chronic stress affects neuronal networks by inducing dendritic retraction, modifying neuronal excitability and plasticity, and modulating glial cells. To elucidate the functional consequences of chronic stress for the hippocampal network, we submitted adult rats to daily restraint stress for 3 weeks (6 h/day). In acute hippocampal tissue slices of stressed rats, basal synaptic function and short-term plasticity at Schaffer collateral/CA1 neuron synapses were unchanged while long-term potentiation was markedly impaired. The spatiotemporal propagation pattern of hypoxia-induced spreading depression episodes was indistinguishable among control and stress slices. However, the duration of the extracellular direct current potential shift was shortened after stress. Moreover, K+ fluxes early during hypoxia were more intense, and the postsynaptic recoveries of interstitial K+ levels and synaptic function were slower. Morphometric analysis of immunohistochemically stained sections suggested hippocampal shrinkage in stressed rats, and the number of cells that are immunoreactive for glial fibrillary acidic protein was increased in the CA1 subfield indicating activation of astrocytes. Western blots showed a marked downregulation of the inwardly rectifying K+ channel Kir4.1 in stressed rats. Yet, resting membrane potentials, input resistance, and K+-induced inward currents in CA1 astrocytes were indistinguishable from controls. These data indicate an intensified interstitial K+ accumulation during hypoxia in the hippocampus of chronically stressed rats which seems to arise from a reduced interstitial volume fraction rather than impaired glial K+ buffering. One may speculate that chronic stress aggravates hypoxia-induced pathophysiological processes in the hippocampal network and that this has implications for the ischemic brain. PMID:22470344

  7. Using Child Age or Weight in Selecting Type of In-Vehicle Restraint: Implications For Promotion And Design

    OpenAIRE

    Anderson, Robert W. G.; Hutchinson, T. Paul; Edwards, Sally A.

    2007-01-01

    A survey of motor vehicle child restraint use found around 28% of children under the age of six using weight-inappropriate restraints. Many parents did not know when a child was likely to outgrow a booster seat nor the weight of their child, but they did know the child’s age. Anthropometric data show that, if advice on restraint transition, given solely in terms of age (6 months, 4 years, 8 years) were followed in Australia, incorrect restraint selection would occur in 5% of children under th...

  8. Capacity Building

    International Nuclear Information System (INIS)

    Outcomes & Recommendations: • Significant increase needed in the nuclear workforce both to replace soon-to-retire current generation and to staff large numbers of new units planned • Key message, was the importance of an integrated approach to workforce development. • IAEA and other International Organisations were asked to continue to work on Knowledge Management, Networks and E&T activities • IAEA requested to conduct Global Survey of HR needs – survey initiated but only 50% of operating countries (30% of capacity) took part, so results inconclusive

  9. Motivating drivers to correctly adjust head restraints: assessing effectiveness of three different interventions.

    Science.gov (United States)

    Fockler, S K; Vavrik, J; Kristiansen, L

    1998-11-01

    Three types of driver educational strategies were tested to determine the most effective approach for motivating drivers to adjust their head restraints to the correct vertical position: (1) a human interactive personal contact with a member of an ICBC-trained head restraint adjustment team, (2) a passive video presentation of the consequences of correct and incorrect head restraint adjustment, and (3) an interactive three-dimensional kinetic model showing the consequences of correct and incorrect head restraint adjustment. An experimental pretest-posttest control group design was used. A different educational treatment was used in each of three lanes of a vehicle emissions testing facility, with a fourth lane with no intervention serving as a control group. Observational and self-reported data were obtained from a total of 1,974 vehicles entering and exiting the facility. The human intervention led to significantly more drivers actually adjusting their head restraints immediately after the intervention than the passive video or interactive kinetic model approaches, which were both no different from the control group. The human intervention was recommended as the most effective and was implemented successfully on a limited basis during 3 months of 1995 and again during 3 months of 1996.

  10. Behavioral response and cost comparison of manual versus pharmacologic restraint protocols in healthy dogs.

    Science.gov (United States)

    Barletta, Michele; Raffe, Marc

    2016-03-01

    Although sedatives are routinely administered to dogs for diagnostic and minimally invasive procedures, manual restraint is often used. The study compared intra-procedural behavioral response, scored on a 100-point, visual analog scale, and cost of restraint in healthy dogs given 1 of 5 treatments: manual restraint, dexmedetomidine at 125 μg/m(2) (Dex 125) or 375 μg/m(2) (Dex 375), Dex 125 plus butorphanol at 0.4 mg/kg (Dex 125 + Bu), or Dex 375 plus butorphanol at 0.4 mg/kg (Dex 375 + Bu). Mean behavioral response scores in dogs declined from baseline in the manual restraint group and improved in a linear fashion in the group order Dex 125, Dex 375, Dex 125 + Bu, and Dex 375 + Bu. Dexmedetomidine at 375 μg/m(2) or at 125 μg/m(2) or at 375 μg/m(2) in combination with butorphanol produced the best intra-procedural behavioral response. The cost of sedative drugs was offset by the opportunity cost of diverting personnel from revenue-generating activity to manual restraint. PMID:26933261

  11. Restraint Stress Impairs Glucose Homeostasis Through Altered Insulin Signalling in Sprague-Dawley Rat.

    Science.gov (United States)

    Morakinyo, Ayodele O; Ajiboye, Kolawole I; Oludare, Gabriel O; Samuel, Titilola A

    2016-01-01

    The study investigated the potential alteration in the level of insulin and adiponectin, as well as the expression of insulin receptors (INSR) and glucose transporter 4 GLUT-4 in chronic restraint stress rats. Sprague-Dawley rats were randomly divided into two groups: the control group and stress group in which the rats were exposed to one of the four different restraint stressors; 1 h, twice daily for a period of 7 days (S7D), 14 days (S14D) and 28 days (S28D). Glucose tolerance and insulin sensitivity were evaluated following the final stress exposure. ELISA were performed to assess the level of insulin and adiponectin as well as expression of INSR and GLUT4 protein in skeletal muscle. Plasma corticosterone level was also determined as a marker of stress exposure. Restraint stress for 7 days caused transient glucose intolerance, while S14D rats demonstrated increased glucose intolerance and insulin insensitivity. However, restraint stress for 28 days had no effect on glucose tolerance, but did cause an increase in glucose response to insulin challenge. The serum level of adiponectin was significantly (pcontrol value while insulin remained unchanged except at in S28D rats that had a significant (pcontrol counterparts. Restraint stress caused glucose intolerance and insulin insensitivity in male Sprague-Dawley rats, which becomes accommodated with prolonged exposure and was likely related to the blunted insulin signalling in skeletal muscle. PMID:27574760

  12. Depressed affect and dietary restraint in adolescent boys' and girls' eating in the absence of hunger.

    Science.gov (United States)

    Kelly, Nichole R; Shomaker, Lauren B; Pickworth, Courtney K; Grygorenko, Mariya V; Radin, Rachel M; Vannucci, Anna; Shank, Lisa M; Brady, Sheila M; Courville, Amber B; Tanofsky-Kraff, Marian; Yanovski, Jack A

    2015-08-01

    Data suggest that depressed affect and dietary restraint are related to disinhibited eating patterns in children and adults. Yet, experimental research has not determined to what extent depressed affect acutely affects eating in the absence of physiological hunger (EAH) in adolescents. In the current between-subjects experimental study, we measured EAH in 182 adolescent (13-17 y) girls (65%) and boys as ad libitum palatable snack food intake after youth ate to satiety from a buffet meal. Just prior to EAH, participants were randomly assigned to view either a sad or neutral film clip. Dietary restraint was measured with the Eating Disorder Examination. Adolescents who viewed the sad film clip reported small but significant increases in state depressed affect relative to adolescents who viewed the neutral film clip (p < .001). Yet, there was no main effect of film condition on EAH (p = .26). Instead, dietary restraint predicted greater EAH among girls, but not boys (p < .001). These findings provide evidence that adolescent girls' propensity to report restrained eating is associated with their greater disinhibited eating in the laboratory. Additional experimental research, perhaps utilizing a more potent laboratory stressor and manipulating both affective state and dietary restraint, is required to elucidate how state affect may interact with dietary restraint to influence EAH during adolescence.

  13. Influence of dosage and chemical restraints on feline excretory urography

    Directory of Open Access Journals (Sweden)

    R.A. Ajadi

    2006-06-01

    Full Text Available Three series of trials involving 10 domestic short-haired cats were carried out to determine the influence of dosage of contrast media or type of chemical restraint on feline excretory urography. The 1st series (group A involved 5 cats sedated with 2.0 mg/kg intramuscular (i.m injection of 2 % xylazine and receiving 800 mg/kg of 76 % meglumine diatrizoate (urografin. The 2nd series (group B involved another 5 cats sedated with 2.0 mg/kg (i.m injection of 2 % xylazine and receiving 1200 mg/kg of 76% urografin. The 3rd series (group C involved the repeat urography of the group B cats but sedated with 15 mg/kg (i.m injection of 5% ketamine hydrochloride. Ventrodorsal radiographs were obtained immediately, 5, 15 and 40 minutes after the injection of 76 % urografin. Scores were assigned to nephrographic opacification as described in the literature. The heart rates, respiratory rates and rectal temperatures of the cats were also determined before sedation, after sedation, immediately after the injection of 76 % urografin and at 15-minute intervals over a period of 60 minutes. In this study, there were significant differences (P < 0.05 in the nephrographic opacification scores between the group A and group B cats at times 0 and 40 minutes post-administration of urografin. Group A cats had good initial nephrographic opacification which faded later while the nephrographic opacification of group B cats progressively increased. Similarly, nephrographic opacification was significantly (P < 0.05 higher in the xylazine-sedated cats (groups A and B than the ketamine-sedated cats (group C. However, there were no significant differences (P > 0.05 in heart rates, respiratory rates and rectal temperatures between the 3 groups of cats. It was therefore concluded that increasing the dosage of urografin above 800 mg/kg in cats does not provide additional beneficial effects on the nephrograms produced. Xylazine sedation was observed to produce better nephrographic

  14. Preliminary evaluation of wheelchair occupant restraint system usage in motor vehicles.

    Science.gov (United States)

    van Roosmalen, Linda; Bertocci, Gina E; Hobson, Douglas A; Karg, Patricia

    2002-01-01

    Individuals using wheeled mobility devices (WMDs) often use them as motor vehicle seats during transportation. Wheelchair occupant restraint systems (WORSs), consisting of upper torso and pelvic restraints, are usually mounted to the structure of transit vehicles to secure individuals within their wheelchair seats. This preliminary study attempts to evaluate the use and satisfaction of currently installed vehicle-mounted WORSs for individuals using WMD as seats in motor vehicles. A survey was conducted among 33 adults who use their WMD to travel in motor vehicles. Results from the survey showed that upper torso and pelvic restraints installed in private vehicles are quick, comfortable, and easy to use. However, WORS installed in mass transit and paratransit are often uncomfortable to wear, difficult to reach, and time-consuming to use. This preliminary study documents the growing need for developing alternative WORS that are safe, comfortable, and that allow independent usage for wheelchair occupants while traveling in a motor vehicle.

  15. Improving Working Conditions for Astronauts: An Electronic Personal Restraint System for Use in Microgravity Environments

    Directory of Open Access Journals (Sweden)

    Kevin Tait

    2012-01-01

    Full Text Available While in microgravity, astronauts are preoccupied with physical restraint, which takes attention away from the maintenance task or scientific experiment at hand. This may directly lead to safety concerns and increased time for extravehicular activity, as well as potentially inhibit or corrupt data collection. A primary concern is the time it takes to manipulate the current restraint system. The portable foot restraint currently in use by NASA employs a series of pins in order to engage the system or release in an emergency. This requires considerable time for the user to detach, and there is an increased risk of entanglement. If restraint operating time could be reduced by 50%, the astronaut’s assigned experiment time could be increased an average of 100 minutes per mission. Another problem identified by NASA included the inability of the current system to release the user upon failure. Research and design was conducted following the Six-Sigma DMEDI project architecture, and a new form of restraint to replace the existing system was proposed. The research team first studied the customer requirements and relevant standards set by NASA, and with this information they began drafting designs for a solution. This project utilized electromagnetism to restrain a user in microgravity. The proposed system was capable of being manipulated quickly, failing in a manner that released the user, and being electronically controlled. This active electronic control was a new concept in restraint systems, as it enabled an astronaut to effectively “walk” along a surface while remaining restrained to it. With the design prototype and a limited budget, a rudimentary test assembly was built by the team, and most of NASA’s specifications were met. With recommendations from NASA, the research team concluded by developing potential material and design solutions that can be explored in the future by Purdue University or other parties.

  16. The effects of sex and hormonal status on restraint-stress-induced working memory impairment

    Directory of Open Access Journals (Sweden)

    Brennan Avis

    2006-03-01

    Full Text Available Abstract Background Restraint stress has been shown to elicit numerous effects on hippocampal function and neuronal morphology, as well as to induce dendritic remodeling in the prefrontal cortex (PFC. However, the effects of acute restraint stress on PFC cognitive function have not been investigated, despite substantial evidence that the PFC malfunctions in many stress-related disorders. Methods The present study examined the effects of restraint stress on PFC function in both male rats and cycling female rats in either the proestrus (high estrogen or estrus (low estrogen phase of the estrus cycle. Animals were restrained for 60 or 120 minutes and then tested on spatial delayed alternation, a PFC-mediated task. Performance after stress was compared to performance on a different day under no-stress conditions, and analyzed using analysis of variance (ANOVA. Results Sixty minutes of restraint impaired only females in proestrus, while 120 minutes of restraint produced significant impairments in all animals. Increases in task completion times did not affect performance. Conclusion These results demonstrate an interaction between hormonal status and cognitive response to stress in female rats, with high estrogen levels being associated with amplified sensitivity to stress. This effect has been previously observed after administration of a pharmacological stressor (the benzodiazepine inverse agonist FG7142, and results from both studies may be relevant to the increased prevalence of stress-related disorders, such as major depressive disorder, in cycling women. Overall, the results show that restraint stress has important effects on the cognitive functions of the PFC, and that hormonal influences in the PFC are an important area for future research.

  17. The ESA astronaut sleep restraint--its development and use onboard Spacelab and MIR.

    Science.gov (United States)

    Ockels, W; Stoewer, H

    1990-02-01

    The development of the ESA portable sleep restraint system is described. The system was developed to simulate certain earthbound sleep conditions in microgravity. The restraint is a bag made of two sheets of Nomex(R) cloth stretched over a tubular tension device and provides the astronaut with feedback pressure similar to bedding on Earth. The final prototype of the bag was tested on the German Spacelab-D1 mission and during a six-month mission aboard MIR. Positive feedback from astronauts suggests the need for further evaluation during space flight. PMID:11540491

  18. The External Restraints to Corporative Administration%外部约束下的公司治理

    Institute of Scientific and Technical Information of China (English)

    崔新有

    2004-01-01

    Corporative efficiency in operation and logic administration relies not only on the good functionality of internal control mechanism, but also on that of external management. Business administrators usually maintain that an ideal restricting mechanism involves internal stimulating tools as well as external restraints. This paper aims to analyze the factors in external, restraints, which leads to some feasible proposals.

  19. How old is that child? Validating the accuracy of age assignments in observational surveys of vehicle restraint use

    OpenAIRE

    Moeller, S; Berger, L.; J. Salvador; Helitzer, D

    2002-01-01

    Objectives: Many large scale observational studies of child restraint usage require observers to estimate the ages of the vehicle occupants. The accuracy of age assignments were assessed and possible methods to improve observational accuracy in research and field studies of child restraint use were identified.

  20. Behavioral effects and CRF expression in brain structures of high- and low-anxiety rats after chronic restraint stress.

    Science.gov (United States)

    Wisłowska-Stanek, Aleksandra; Lehner, Małgorzata; Skórzewska, Anna; Krząścik, Paweł; Płaźnik, Adam

    2016-09-01

    The aim of our study was to investigate the influence of chronic restraint stress (5 weeks, 3h/day) on behavior and central corticotropin-releasing factor (CRF) expression in rats selected for high (HR) and low anxiety (LR). The conditioned freezing response was used as a discriminating variable. Moreover, we assessed the influence of acute restraint on CRF expression in the brain in HR and LR rats. We found that chronic restraint induced symptoms of anhedonia (decreased consumption of 1% sucrose solution) in HR rats. In addition, HR restraint rats showed an increased learned helplessness behavior (immobility time in the Porsolt test) as well as neophobia in the open field test vs. LR restraint and HR control rats. These behavioral changes were accompanied by a decreased expression of CRF in the paraventricular nucleus of the hypothalamus (pPVN) and the dentate gyrus of the hippocampus (DG) compared to the HR control and LR restraint rat groups, respectively. The acute restraint condition increased the expression of CRF in the pPVN of HR rats compared to the HR control group, and enhanced the expression of CRF in the CA1 area and DG of LR restraint animals compared to the HR restraint and LR control rats, respectively. The present results indicate that chronic restraint stress in high anxiety rats attenuated CRF expression in the pPVN and DG, which was probably due to detrimental actions on the hippocampus-hypothalamus-pituitary-adrenal gland feedback mechanism, thus modulating the stress response and inducing anhedonia and depressive-like symptoms. PMID:27150225

  1. Transient influence of end-tidal carbon dioxide tension on the postural restraint in cerebral perfusion

    NARCIS (Netherlands)

    R.V. Immink; J. Truijen; N.H. Secher; J.J. van Lieshout

    2009-01-01

    Immink RV, Truijen J, Secher NH, Van Lieshout JJ. Transient influence of end-tidal carbon dioxide tension on the postural restraint in cerebral perfusion. J Appl Physiol 107: 816-823, 2009. First published July 2, 2009; doi: 10.1152/japplphysiol.91198.2008.-In the upright position, cerebral blood fl

  2. A Ban on Prior Restraint in High Schools: The Aftermath of the "Fujishima" Decision.

    Science.gov (United States)

    Trager, Robert; Dickerson, Donna L.

    After a unique court decision forbidding prior restraint in public high school publications in three states, a study was devised based on the responses to individual questionnaires sent to principals, faculty advisers, and student editors in each of the schools in the judicial district involved in the decision. Respondents answered questions…

  3. Judicial Restraints on the Press. Freedom of Information Foundation Series No. 2.

    Science.gov (United States)

    Gillmor, Donald M.

    The purpose of this paper is to examine the current status of freedom of the press with regard to past and present judicial rulings. A section devoted to "The Background of Prior Restraint" examines the historical basis for current legal decisions. In "Threatening Progeny," court decisions unfriendly to the press such as the Reardon Report, the…

  4. The Relationship between Seclusion and Restraint Use and Childhood Abuse among Psychiatric Inpatients

    Science.gov (United States)

    Hammer, Joseph H.; Springer, Justin; Beck, Niels C.; Menditto, Anthony; Coleman, James

    2011-01-01

    Seclusion and restraint (S/R) is a controversial topic in the field of psychiatry, due in part to the high rates of childhood physical and sexual abuse found among psychiatric inpatients. The trauma-informed care perspective suggests that the use of S/R with previously abused inpatients may result in retraumatization due to mental associations…

  5. Pasung: Physical restraint and confinement of the mentally ill in the community

    Directory of Open Access Journals (Sweden)

    Diatri Hervita

    2008-06-01

    Full Text Available Abstract Background Physical restraint and confinement (pasung by families of people with mental illness is known to occur in many parts of the world but has attracted limited investigation. This preliminary observational study was carried out on Samosir Island in Sumatra, Indonesia, to investigate the nature of such restraint and confinement, the clinical characteristics of people restrained, and the reasons given by families and communities for applying such restraint. Methods The research method was cross-sectional observational research in a natural setting, carried out during a six-month period of working as the only psychiatrist in a remote district. Results Fifteen cases of pasung, approximately even numbers of males and females and almost all with a diagnosis of schizophrenia were identified. Duration of restraint ranged from two to 21 years. Discussion and Conclusion The provision of basic community mental health services, where there were none before, enabled the majority of the people who had been restrained to receive psychiatric treatment and to be released from pasung.

  6. 28 CFR 552.22 - Principles governing the use of force and application of restraints.

    Science.gov (United States)

    2010-07-01

    ... destination. (f) Restraints should remain on the inmate until self-control is regained. (g) Except when the... inmate. (c) Staff shall use only that amount of force necessary to gain control of the inmate. Situations... protection of self or others; (2) Enforcement of institutional regulations; and (3) The prevention of a...

  7. Changing the Definition of Education. On Kant's Educational Paradox between Freedom and Restraint

    Science.gov (United States)

    Schaffar, Birgit

    2014-01-01

    Ever since Kant asked: "How am I to develop the sense of freedom in spite of the restraint?" in his lecture on education, the tension between necessary educational influence and unacceptable restriction of the child's individual development and freedom has been considered an educational paradox. Many have suggested solutions to the…

  8. 14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Use of safety belts, shoulder harnesses, and child restraint systems. 91.107 Section 91.107 Aeronautics and Space FEDERAL AVIATION... was approved by the FAA through Type Certificate or Supplemental Type Certificate. (iv) That the...

  9. Learning from Tragedy: A Survey of Child and Adolescent Restraint Fatalities

    Science.gov (United States)

    Nunno, Michael A.; Holden, Martha J.; Tollar, Amanda

    2006-01-01

    Objective: This descriptive study examines 45 child and adolescent fatalities related to restraints in residential (institutional) placements in the United States from 1993 to 2003. Method: The study team used common Internet search engines as its primary case discovery strategy to determine the frequency and the nature of the fatalities, as well…

  10. Reducing Seclusion Timeout and Restraint Procedures with At-Risk Youth

    Science.gov (United States)

    Ryan, Joseph B.; Peterson, Reece; Tetreault, George; Hagen, Emily Vander

    2007-01-01

    The purpose of this pilot study was to review the effects of professional staff training in crisis management and de-escalation techniques on the use of seclusion timeout and restraint procedures with at-risk students in a K-12 special day school. An exploratory pre-post study was conducted over a two-year period, comparing the use of these…

  11. Reduction of Restraint of People with Intellectual Disabilities: An Organizational Behavior Management (OBM) Approach

    Science.gov (United States)

    Williams, Don E.; Grossett, Deborah L.

    2011-01-01

    We used an organizational behavior management (OBM) approach to increase behavior intervention plans and decrease the use of mechanical restraint. First, recipients were tracked as a member of the priority group if they engaged in frequent self-injurious behavior or physical aggression toward others and/or if they had been placed in mechanical…

  12. 76 FR 16472 - Consumer Information; Program for Child Restraint Systems; Correction

    Science.gov (United States)

    2011-03-23

    ... determine reasonable conditions for participation in a new consumer information program, as part of the New... published in the Federal Register of February 25, 2011 (76 FR 10637), a request for comments notice describing the new consumer information program that will help caregivers find a child restraint system...

  13. Maternal restraint and external eating behaviour are associated with formula use or shorter breastfeeding duration.

    Science.gov (United States)

    Brown, A

    2014-05-01

    Maternal eating behaviour (e.g. restraint, disinhibition) has been associated with maternal child-feeding style (e.g. pressure to eat, restricting intake, monitoring) for children over the age of two years. In particular, mothers high in restraint are significantly more likely to restrict and monitor their child's intake of food. Research has not however examined the impact of maternal eating behaviour upon earlier infant feeding. A controlling maternal child-feeding style has been linked with shorter breastfeeding duration and earlier introduction of solid foods but the relationship between infant milk feeding and maternal eating behaviour has not been explored despite links between maternal weight, body image and breastfeeding duration. The aim of the current study was to explore associations between maternal restraint, emotional and external eating and breastfeeding initiation and duration. Seven hundred and fifty-six mothers with an infant aged 6-12months completed a copy of the Dutch Eating Behaviour Questionnaire and reported breastfeeding duration and formula use up to six months postpartum. Mothers high in restraint and external eating were significantly more likely to formula feed from birth, to breastfeed for a shorter duration and to introduce formula milk sooner than those lower in these behaviours. Moreover these behaviours were associated with reporting greater control during milk feeding by feeding to a mother-led rather than baby-led routine. Maternal eating behaviour may therefore affect breastfeeding initiation and continuation and is an important element for discussion for those working to support new mothers. PMID:24463067

  14. Child and Adolescent Inpatient Restraint Reduction: A State Initiative to Promote Strength-Based Care.

    Science.gov (United States)

    LeBel, Janice; Stromberg, Nan; Duckworth, Ken; Kerzner, Joan; Goldstein, Robert; Weeks, Michael; Harper, Gordon; LaFlair, Lareina; Sudders, Marylou

    2004-01-01

    Objective: To reduce the use of restraint and seclusion with children and adolescents in psychiatric inpatient units by promoting a preventive, strength-based model of care. Method: The State Mental Health Authority used data analysis, quality improvement strategies, regulatory oversight, and technical assistance to develop and implement system…

  15. Acute restraint stress induces rapid and prolonged changes in erythrocyte and hippocampal redox status.

    Science.gov (United States)

    Spiers, Jereme G; Chen, Hsiao-Jou; Bradley, Adrian J; Anderson, Stephen T; Sernia, Conrad; Lavidis, Nickolas A

    2013-11-01

    The onset and consequential changes in reduction-oxidation (redox) status that take place in response to short-term stress have not been well defined. This study utilized erythrocytes and neural tissue from male Wistar rats to demonstrate the rapid redox alterations that occur following an acute restraining stress. Serial blood samples collected from catheterized animals were used to measure prolactin, corticosterone, glucose, general oxidative status, and glutathione/glutathione disulfide ratios. Restraint increased prolactin concentration by approximately 300% at 30 min and rapidly returned to baseline values by 120 min of stress. Baseline blood glucose and corticosterone increased during stress exposure by approximately 25% and 150% respectively. Over the experimental period, the erythrocytic oxidative status of restrained animals increased by approximately 10% per hour which persisted after stress exposure, while changes in the glutathione redox couple were not observed until 120 min following the onset of stress. Application of restraint stress increased hippocampal oxidative status by approximately 17% while no change was observed in the amygdala. It was concluded that while endocrine and metabolic markers of stress rapidly increase and habituate to stress exposure, redox status continues to change following stress in both peripheral and neural tissue. Studies with longer post-restraint times and the inclusion of several brain regions should further elucidate the consequential redox changes induced by acute restraint stress.

  16. Effect of honey on the reproductive system of male rat offspring exposed to prenatal restraint stress.

    Science.gov (United States)

    Haron, M N; Mohamed, M

    2016-06-01

    Exposure to prenatal stress is associated with impaired reproductive function in male rat offspring. Honey is traditionally used by the Malays for enhancement of fertility. The aim of this study was to determine the effect of honey on reproductive system of male rat offspring exposed to prenatal restraint stress. Dams were divided into four groups (n = 10/group): control, honey, stress and honey + stress groups. Dams from honey and honey + stress groups received oral honey (1.2 g kg(-1) body weight) daily from day 1 of pregnancy, meanwhile dams from stress and honey + stress groups were subjected to restraint stress (three times per day) from day 11 of pregnancy until delivery. At 10 weeks old, each male rat offspring was mated with a regular oestrus cycle female. Male sexual behaviour and reproductive performance were evaluated. Then, male rats were euthanised for assessment on reproductive parameters. Honey supplementation during prenatal restraint stress significantly increased testis and epididymis weights as well as improved the percentages of abnormal spermatozoa and sperm motility in male rat offspring. In conclusion, this study might suggest that supplementation of honey during pregnancy seems to reduce the adverse effects of restraint stress on reproductive organs weight and sperm parameters in male rat offspring. PMID:26289766

  17. Protecting children: a survey of caregivers’ knowledge of Georgia’s child restraint laws

    Directory of Open Access Journals (Sweden)

    Sheryl Strasser

    2010-11-01

    Full Text Available Sheryl Strasser1, Laurie Whorton2, Amanda J Walpole3, Sarah Beddington11Institute of Public Health, Partnership for Urban Health Research, Georgia State University, Atlanta, GA, USA; 2WellStar Corporate and Community Health, Marietta, GA, USA; 3Cobb and Douglas Public Health, Marietta, GA, USAIntroduction: The leading cause of injury and death among children in the United States is motor vehicle crashes. Even though restraint laws are in place and public awareness campaigns and educational interventions have increased, many children are still improperly restrained or not restrained at all. When correctly used, child restraints significantly reduce risk of injury or death.Methods: The purpose of the study was to elicit caregiver baseline knowledge of car seat installation and regulation before receiving car seat education from certified technicians at Inspection Station events. Inspection Station is a program whereby staff assists parents in correctly positioning car seats in participants’ vehicles. Over an 8-week period, Safe Kids Cobb County Car Seat Technicians distributed a 16-item survey, with 10 knowledge-based questions and six demographic questions to Inspection Station participants. Descriptive statistics and t-tests were conducted to assess relationships between participant age, ethnicity, and gender with overall knowledge scores. Regression analysis was run to determine the association between participant education level and total child restraint knowledge.Results: One hundred sixty-nine surveys were completed. Participant knowledge of vehicular child restraint ranged from 0% to 90% on all items. Only 29.6% of caregivers understood the proper tightness of the harness system. Less than half of the caregivers (43.8% were aware of the Georgia law requiring children aged 6 years and younger to be in some type of child restraint. Only 43.2% of caregivers surveyed knew that children need to ride in a rear-facing child restraint until 1

  18. Greater physiological and behavioral effects of interrupted stress pattern compared to daily restraint stress in rats.

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    Wei Zhang

    Full Text Available Repeated stress can trigger a range of psychiatric disorders, including anxiety. The propensity to develop abnormal behaviors after repeated stress is related to the severity, frequency and number of stressors. However, the pattern of stress exposure may contribute to the impact of stress. In addition, the anxiogenic nature of repeated stress exposure can be moderated by the degree of coping that occurs, and can be reflected in homotypic habituation to the repeated stress. However, expectations are not clear when a pattern of stress presentation is utilized that diminishes habituation. The purpose of these experiments is to test whether interrupted stress exposure decreases homotypic habituation and leads to greater effects on anxiety-like behavior in adult male rats. We found that repeated interrupted restraint stress resulted in less overall homotypic habituation compared to repeated daily restraint stress. This was demonstrated by greater production of fecal boli and greater corticosterone response to restraint. Furthermore, interrupted restraint stress resulted in a lower body weight and greater adrenal gland weight than daily restraint stress, and greater anxiety-like behavior in the elevated plus maze. Control experiments demonstrated that these effects of the interrupted pattern could not be explained by differences in the total number of stress exposures, differences in the total number of days that the stress periods encompased, nor could it be explained as a result of only the stress exposures after an interruption from stress. These experiments demonstrate that the pattern of stress exposure is a significant determinant of the effects of repeated stress, and that interrupted stress exposure that decreases habituation can have larger effects than a greater number of daily stress exposures. Differences in the pattern of stress exposure are therefore an important factor to consider when predicting the severity of the effects of repeated

  19. Price Elasticity of Demand and Capacity-Restraint Transit Fare Strategy: A Case Study of Bangkok Mass Transit System

    OpenAIRE

    Ackchai Sirikijpanichkul; Sarintorn Winyoopadit

    2015-01-01

    Traffic congestion is a chronic problem of Bangkok. Similar to other metropolises, the city perpetually seeks for alternatives to road travel. Mass rapid transit seems to be the only way out that is expected to mitigate traffic congestion in the city. However, without common fare system, travelers need to pay an initial entrance fee every time they enter each transit system. This excess cost tapers the demand and affects the efficient use of the system. This research investigates the influenc...

  20. Price Elasticity of Demand and Capacity-Restraint Transit Fare Strategy: A Case Study of Bangkok Mass Transit System

    Directory of Open Access Journals (Sweden)

    Ackchai Sirikijpanichkul

    2015-01-01

    Full Text Available Traffic congestion is a chronic problem of Bangkok. Similar to other metropolises, the city perpetually seeks for alternatives to road travel. Mass rapid transit seems to be the only way out that is expected to mitigate traffic congestion in the city. However, without common fare system, travelers need to pay an initial entrance fee every time they enter each transit system. This excess cost tapers the demand and affects the efficient use of the system. This research investigates the influence of fare price on transit use which is measured by price elasticity of demand and proposes the optimum fare price if the common fare is used. The analysis is based on the findings from the stated preference survey techniques. Finally, the conclusion on fare level that encourage more patronage, maintain service quality and operator revenue is addressed.

  1. Nurses using physical restraints: Are the accused also the victims? – A study using focus group interviews

    Directory of Open Access Journals (Sweden)

    Lai Claudia KY

    2007-07-01

    Full Text Available Abstract Background To date, the literature has provided an abundance of evidence on the adverse outcomes of restraint use on patients. Reportedly, nurses are often the personnel who initiate restraint use and attribute its use to ensuring the safety of the restrained and the others. A clinical trial using staff education and administrative input as the key components of a restraint reduction program was conducted in a rehabilitation setting to examine whether there were any significant differences in the prevalence of restraint use pre- and post-intervention. Subsequent to the implementation of the intervention program, focus group interviews were conducted to determine the perspective of the nursing staff on the use of restraints and their opinions of appropriate means to reduce their use. Method Registered nurses working in units involved in the study were invited to participate in focus group interviews on a voluntary basis. Twenty-two registered nurses (three males [13.6%] and nineteen females [86.4%] attended the four sessions. All interviews were audio taped and transcribed verbatim. Other than the author, another member of the project team validated the findings from the data analysis. Results Four themes were identified. Participants experienced internal conflicts when applying physical restraints and were ambivalent about their use, but they would use restraints nonetheless, mainly to prevent falls and injuries to patients. They felt that nurse staffing was inadequate and that they were doing the best they could. They experienced pressure from the management level and would have liked better support. Communication among the various stakeholders was a problem. Each party may have a different notion about what constitutes a restraint and how it can be safely used, adding further weight to the burden shouldered by staff. Conclusion Studies about restraints and restraint use have mostly focused on nurses' inadequate and often inaccurate

  2. A new default restraint library for the protein backbone in Phenix: a conformation-dependent geometry goes mainstream

    Science.gov (United States)

    Moriarty, Nigel W.; Tronrud, Dale E.; Adams, Paul D.; Karplus, P. Andrew

    2016-01-01

    Chemical restraints are a fundamental part of crystallographic protein structure refinement. In response to mounting evidence that conventional restraints have shortcomings, it has previously been documented that using backbone restraints that depend on the protein backbone conformation helps to address these shortcomings and improves the performance of refinements [Moriarty et al. (2014 ▸), FEBS J. 281, 4061–4071]. It is important that these improvements be made available to all in the protein crystallography community. Toward this end, a change in the default geometry library used by Phenix is described here. Tests are presented showing that this change will not generate increased numbers of outliers during validation, or deposition in the Protein Data Bank, during the transition period in which some validation tools still use the conventional restraint libraries. PMID:26894545

  3. The Validity of the Doctrine of Restraint of Trade Under the Nigerian Labour Law

    Directory of Open Access Journals (Sweden)

    Uko, E. J.

    2013-08-01

    Full Text Available The doctrine of restraint of trade presents itself as a double-edged sword that can both do and undo. While it seeks to prevent abuse in regards to certain trade practices on the one hand, it tends to proffer excessive abuse and violations of the individuals’ rights to certain trade freedoms, if wrongly and widely applied, on the other hand. This article explores the various dimensions that cut across diverse boundaries touching human rights, ethics, equity, trade customs and other considerations. In as much as the doctrine of restraint of trade has come to stay, the courts as final arbiters have ensured that there be standards and guides, and this helped them to, in any given case, decide whether such agreement is valid or not. In conclusion, therefore, this work notes that there should be a legal framework, that will reduce likely and imaginary situations and circumstances that may give rise to litigations in black and white.

  4. Unexpected death related to restraint for excited delirium: a retrospective study of deaths in police custody and in the community

    OpenAIRE

    Pollanen, M. S.; Chiasson, D A; Cairns, J T; Young, J G

    1998-01-01

    BACKGROUND: Some people in states of excited delirium die while in police custody. Emerging evidence suggests that physical restraint in certain positions may contribute to such deaths. In this study the authors determined the frequency of physical restraint among people in a state of excited delirium who died unexpectedly. METHODS: The authors reviewed the records of 21 cases of unexpected death in people with excited delirium, which were investigated by the Office of the Chief Coroner for O...

  5. Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.

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    Marie Hennebelle

    Full Text Available Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days on adult rats fed omega-3 deficient, control or omega-3 enriched diets from conception. We measured body weight, plasma corticosterone and hippocampus glucocorticoid receptors and correlated these data with emotional and depression-like behaviour assessed by their open-field (OF activity, anxiety in the elevated-plus maze (EPM, the sucrose preference test and the startle response. We also determined their plasma and brain membrane lipid profiles by gas chromatography. Repeated restraint stress caused rats fed a control diet to lose weight. Their plasma corticosterone increased and they showed moderate behavioural changes, with increases only in grooming (OF test and entries into the open arms (EPM. Rats fed the omega-3 enriched diet had a lower stress-induced weight loss and plasma corticosterone peak, and reduced grooming. Rats chronically lacking omega-3 fatty acid exhibited an increased startle response, a stress-induced decrease in locomotor activity and exaggerated grooming. The brain omega-3 fatty acids increased as the dietary omega-3 fatty acids increased; diets containing preformed long-chain omega-3 fatty acid were better than diets containing the precursor alpha-linolenic acid. However, the restraint stress reduced the amounts of omega-3 incorporated. These data showed that the response to chronic restraint stress was modulated by the omega-3 fatty acid supply, a dietary deficiency was deleterious while enrichment protecting against stress.

  6. Housing in Pyramid Counteracts Neuroendocrine and Oxidative Stress Caused by Chronic Restraint in Rats

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    M. Surekha Bhat

    2007-01-01

    Full Text Available The space within the great pyramid and its smaller replicas is believed to have an antistress effect. Research has shown that the energy field within the pyramid can protect the hippocampal neurons of mice from stress-induced atrophy and also reduce neuroendocrine stress, oxidative stress and increase antioxidant defence in rats. In this study, we have, for the first time, attempted to study the antistress effects of pyramid exposure on the status of cortisol level, oxidative damage and antioxidant status in rats during chronic restraint stress. Adult female Wistar rats were divided into four groups as follows: normal controls (NC housed in home cage and left in the laboratory; restrained rats (with three subgroups subject to chronic restraint stress by placing in a wire mesh restrainer for 6 h per day for 14 days, the restrained controls (RC having their restrainers kept in the laboratory; restrained pyramid rats (RP being kept in the pyramid; and restrained square box rats (RS in the square box during the period of restraint stress everyday. Erythrocyte malondialdehyde (MDA and plasma cortisol levels were significantly increased and erythrocyte-reduced glutathione (GSH levels, erythrocyte glutathione peroxidase (GSH-Px and superoxide dismutase (SOD activities were significantly decreased in RC and RS rats as compared to NC. However, these parameters were maintained to near normal levels in RP rats which showed significantly decreased erythrocyte MDA and plasma cortisol and significantly increased erythrocyte GSH levels, erythrocyte GSH-Px and SOD activities when compared with RS rats. The results showed that housing in pyramid counteracts neuroendocrine and oxidative stress caused by chronic restraint in rats.

  7. Least restrictive measures: alternatives to four-point restraints and seclusion.

    Science.gov (United States)

    Morales, E; Duphorne, P L

    1995-10-01

    Following the review and discussion of alternative measures in the use of four-point restraints and seclusion on an acute psychiatric inpatient unit, the staff increased the use of "least restrictive" measures with aggressive patients. This involved increased attention to escalating behavior and using alternatives. Although early recognition did not guarantee success in every situation, patients were included in making choices and being in control of which option to take. When staff became more knowledgeable about the use of alternatives, they were more comfortable offering patients choices and did not wait until restraints and seclusion were necessary. It was beneficial to review the rationale for the use of seclusion and restraints with both patients and staff. Specific approaches for early recognition and intervention focused on verbal control, limit setting, and decreased stimulation. It is important that staff have a clear understanding of their range of treatment strategies from most to "least restrictive" measures during stressful times when patients become confused, angry, or frightened and may lose control. Patients must be made aware of their choices during this cycle and understand the consequences of their behavior. Planning educational inservice programs for staff to address this content and share approaches to specific situations can be effective. Staff debriefing following an incident is crucial to discuss reactions to the use of restraints and seclusion and to plan for the use of alternative measures in the future. All patients need a chance to express themselves. As staff we must take time to stop, look, and listen. We must be aware of our own thoughts and feelings and think of choices. What are the ¿least restrictive¿ measures? We need to work with patients in considering a range of measures without taking unnecessary risks or disregarding issues. We must work with our patients so that we all can learn a valuable lesson. Why not give our

  8. Legal restraints on dissemination of instructional materials by educational communications systems

    Science.gov (United States)

    Bernstein, N. N.

    1972-01-01

    The legal restraints on the use of electronic communications systems for dissemination of instructional materials in the United States are discussed. First the laws are examined relating to public school elementary and secondary education, with primary emphasis on selection of courses of study and instructional materials. The second part contains an examination of the copyright laws, both the copyright law now in effect and the revision thereto currently pending before the Congress of the United States.

  9. Has Child Restraint System Use Increased among Parents of Children in Shantou, China?

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    Huiqian Lei

    2016-09-01

    Full Text Available Objective: to examine parents’ use of child restraint systems (CRS, and determine if parents’ knowledge of, attitude toward, and use behavior of child restraint systems have improved following enactment of child restraint use laws in other cities. Design: Observations and a cross-sectional survey of drivers transporting children 17 years and under were conducted at the gate of the schools and parking lots of hospitals in Shantou. Observers recorded the seating location of child passengers, the type of restraint, and appropriate use of CRS and safety belts based on the observation. Knowledge of and attitudes towards use of CRS were reported by the driver following observation. Results: Approximately 6.6% of passengers aged 0–12 were in CRS; rate of forward-facing CRS in children aged 3–5 (9.9% was higher than rear-facing CRS for children aged 0–2 (1.1% and booster seat use among children aged 6–12 (0.1%. Children younger than four years old (OR = 3.395, 95% CI = 2.125–5.424, drivers having a college or higher lever education (OR = 2.908, 95% CI = 1.878–4.500 and drivers wearing seatbelt (OR = 3.194, 95% CI = 1.605–6.356 had greater odds of CRS use. Over half (56.6% of parents might or would use CRS if they could rent CRSs with fees. Conclusions: The rate of CRS is still low in Shantou. Comprehensive public education programs supported by legislation might be an effective way to improve child passenger safety. Renting CRSs to parents could be a new approach to encourage use.

  10. Restraint Stress-Induced Morphological Changes at the Blood-Brain Barrier in Adult Rats

    OpenAIRE

    Petra eSántha; Szilvia eVeszelka; Zsófia eHoyk; Mária eMészáros; Walter, Fruzsina R.; Andrea E Tóth; Lóránd eKiss; András eKincses; Zita eOláh; György eSeprényi; Gabor eRakhely; András eDér; Magdolna ePákáski; Janos eKalman; Ágnes eKittel

    2016-01-01

    Stress is well-known to contribute to the development of both neurological and psychiatric diseases. While the role of the blood-brain barrier is increasingly recognized in the development of neurodegenerative disorders, such as Alzheimer's disease, dysfunction of the blood-brain barrier has been linked to stress-related psychiatric diseases only recently. In the present study the effects of restraint stress with different duration (1, 3, and 21 days) were investigated on the morphology of th...

  11. Amplified spontaneous emission and its restraint in a terawatt Ti:sapphire amplifier

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Amplified spontaneous emission (ASE) and its restraint in a femtosecond Ti: sapphire chirped_pulse amplifier were investigated. The noises arising from ASE were effectively filtered out in the spatial, temporal and spectral domain. Pulses as short as 38 fs were amplified to peak power of 1.4 TW. The power ratio between the amplified femtosecond pulse and the ASE was higher than 106:1.

  12. Functional genomics of the muscle response to restraint and transport in chickens

    OpenAIRE

    Hazard, Dominique; Fernandez, Xavier; Pinguet, Jérémy; Chambon, Christophe; Letisse, Fabien; Portais, Jean-Charles; Wadih-Moussa, H.; Rémignon, Hervé; Molette, Caroline

    2011-01-01

    In the present study, we used global approaches (proteomics, transcriptomics, and metabolomics) to assess the molecular basis of the muscle response to stress in chickens. A restraint test, combined with transport for 2 h (RT test) was chosen as the potentially stressful situation. Chickens (6 wk old) were either nontreated (control chickens) or submitted to the RT test (treated chickens). The RT test induced a 6-fold increase in corticosterone concentrations, suggesting hypothalamic-pituitar...

  13. Voluntary Export Restraints: UK Restrictions on Imports of Leather Footwear from Eastern Europe

    OpenAIRE

    Brenton, Paul; WINTERS, L Alan

    1988-01-01

    A prominent feature of international trading relations since 1970 has been the spread of quantitative restrictions on imports. This paper describes initial work to quantify and assess the economic effects of such nontariff barriers (NTBs), taking as a case study the United Kingdom footwear industry. By way of example it considers the demand side effects of the voluntary export restraint on UK leather footwear imports from Comecon countries. Previous studies of NTBs have assumed that prices ri...

  14. Negative Modulation of NO for Diaphragmatic Contractile Reduction Induced by Sepsis and Restraint Position

    Institute of Scientific and Technical Information of China (English)

    XIANG Jian; GUAN Su-dong; SONG Xiang-he; WANG Hui-yun; GU Zhen-yong

    2014-01-01

    In practice of forensic medicine, potential disease can be associated with fatal asphyxia in re-straint position. Research has demonstrated that nitric oxide (NO) and nitric oxide synthase (NOS) are plentifully distributed in skeletal muscle, contributing to the regulation of contractile and relaxation. In the current study, respiratory functions, indices of diaphragmatic biomechanical functions ex vivo, as well as NO levels in serum, the expressions of diaphragmatic inducible NOS (iNOS) mRNA, and the effects of L-NNA on contractility of the diaphragm were observed in sepsis induced by cecal ligation and punc-ture (CLP) under the condition of restraint position. The results showed that in the CLP12-18 h rats, respiratory dysfunctions; indices of diaphragmatic biomechanical functions (Pt, +dT/dtmax, -dT/dtmax, CT, Po, force over the full range of the force-frequency relationship and fatigue resistance ) declined progressive-ly; the NO level in serum, and iNOS mRNA expression in the diaphragm increased progressively; force increased significantly at all stimulation frequencies after L-NNA pre-incubation. Restraint position 1 h in CLP12 h rats resulted in severe respiratory dysfunctions after relative stable respiratory functions, almost all the indices of diaphragmatic biomechanical functions declined further, whereas little change took place in NO level in serum and diaphragmatic iNOS mRNA expression; and the effects of L-NNA were lack of statistical significance compared with those of CLP12 h, but differed from CLP18 h group. These results suggest that restraint position and sepsis act together in a synergistic manner to aggravate the great reduction of diaphragmatic contractility via, at least in part, the negative modulation of NO, which may contribute to the pathogenesis of positional asphyxia.

  15. Acute Restraint Stress Enhances Hippocampal Endocannabinoid Function via Glucocorticoid Receptor Activation

    OpenAIRE

    Wang, Meina; Hill, Matthew N.; Zhang, Longhua; Gorzalka, Boris B.; Hillard, Cecilia J.; Alger, Bradley E.

    2011-01-01

    Exposure to behavioral stress normally triggers a complex, multi-level response of the hypothalamic-pituitary-adrenal (HPA) axis that helps maintain homeostatic balance. Although the endocannabinoid (eCB) system (ECS) is sensitive to chronic stress, few studies have directly addressed its response to acute stress. Here we show that acute restraint stress enhances eCB-dependent modulation of GABA release measured by whole-cell voltage clamp of inhibitory post-synaptic currents (IPSCs) in rat h...

  16. Cognitive dietary restraint is associated with eating behaviors, lifestyle practices, personality characteristics and menstrual irregularity in college women.

    Science.gov (United States)

    McLean, Judy A; Barr, Susan I

    2003-04-01

    This study characterized associations of restraint with selected physical, lifestyle, personality and menstrual cycle characteristics in female university students. The survey instrument, distributed to 1350 women, included standardized questionnaires (Three-Factor Eating Questionnaire, Perceived Stress Scale and Rosenberg's Self-esteem Scale), and assessed weight and dieting history, exercise, lifestyle characteristics, menstrual cycle characteristics and whether participants were following vegetarian diets. Among the 596 respondents included in the analysis (44%), women with high (n=145), medium (n=262) or low (n=189) restraint had similar ages, heights and weights. Despite this, compared to women with low scores, those with high scores exercised more (4.6+/-5.3 vs. 3.2+/-3.5 h/wk), were more likely to be vegetarian (14.5 vs. 3.7%), have a history of eating disorders (13.7 vs. 1.2%), be currently trying to lose weight (80.3 vs. 15.3%), report irregular menstrual cycles (34.7 vs. 17.0%), and have scores reflecting lower self-esteem and higher perceived stress. Menstrual irregularity was an independent predictor of restraint score, and restraint score was the only variable to differentiate women with regular and irregular menstrual cycles. We conclude that women with high restraint may use a combination of behavioral strategies for weight control, and differ from women with low restraint scores in personality characteristics and weight history. Some of these behaviors or characteristics may influence menstrual function.

  17. Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints.

    Science.gov (United States)

    Finn, Jessica A; Koehler Leman, Julia; Willis, Jordan R; Cisneros, Alberto; Crowe, James E; Meiler, Jens

    2016-01-01

    Structural restrictions are present even in the most sequence diverse portions of antibodies, the complementary determining region (CDR) loops. Previous studies identified robust rules that define canonical structures for five of the six CDR loops, however the heavy chain CDR 3 (HCDR3) defies standard classification attempts. The HCDR3 loop can be subdivided into two domains referred to as the "torso" and the "head" domains and two major families of canonical torso structures have been identified; the more prevalent "bulged" and less frequent "non-bulged" torsos. In the present study, we found that Rosetta loop modeling of 28 benchmark bulged HCDR3 loops is improved with knowledge-based structural restraints developed from available antibody crystal structures in the PDB. These restraints restrict the sampling space Rosetta searches in the torso domain, limiting the φ and ψ angles of these residues to conformations that have been experimentally observed. The application of these restraints in Rosetta result in more native-like structure sampling and improved score-based differentiation of native-like HCDR3 models, significantly improving our ability to model antibody HCDR3 loops. PMID:27182833

  18. Vervet monkeys solve a multiplayer "forbidden circle game" by queuing to learn restraint.

    Science.gov (United States)

    Fruteau, Cécile; van Damme, Eric; Noë, Ronald

    2013-04-22

    In social dilemmas, the ability of individuals to coordinate their actions is crucial to reach group optima. Unless exacted by power or force, coordination in humans relies on a common understanding of the problem, which is greatly facilitated by communication. The lack of means of consultation about the nature of the problem and how to solve it may explain why multiagent coordination in nonhuman vertebrates has commonly been observed only when multiple individuals react instantaneously to a single stimulus, either natural or experimentally simulated, for example a predator, a prey, or a neighboring group. Here we report how vervet monkeys solved an experimentally induced coordination problem. In each of three groups, we trained a low-ranking female, the "provider," to open a container holding a large amount of food, which the providers only opened when all individuals dominant to them ("dominants") stayed outside an imaginary "forbidden circle" around it. Without any human guidance, the dominants learned restraint one by one, in hierarchical order from high to low. Once all dominants showed restraint immediately at the start of the trial, the providers opened the container almost instantly, saving all individuals opportunity costs due to lost foraging time. Solving this game required trial-and-error learning based on individual feedback from the provider to each dominant, and all dominants being patient enough to wait outside the circle while others learned restraint. Communication, social learning, and policing by high-ranking animals played no perceptible role.

  19. The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice.

    Science.gov (United States)

    Lee, Jun Ho; Kim, Tae-Jin; Kim, Jie Wan; Yoon, Jeong Seon; Kim, Hyuk Soon; Lee, Kyung-Mi

    2016-08-01

    Thymic atrophy is a complication that results from exposure to many environmental stressors, disease treatments, and microbial challenges. Such acute stress-associated thymic loss can have a dramatic impact on the host's ability to replenish the necessary naïve T cell output to reconstitute the peripheral T cell numbers and repertoire to respond to new antigenic challenges. We have previously reported that treatment with the orexigenic hormone ghrelin results in an increase in the number and proliferation of thymocytes after dexamethasone challenge, suggesting a role for ghrelin in restraint stress-induced thymic involution and cell apoptosis and its potential use as a thymostimulatory agent. In an effort to understand how ghrelin suppresses thymic T cell apoptosis, we have examined the various signaling pathways induced by receptor-specific ghrelin stimulation using a restraint stress mouse model. In this model, stress-induced apoptosis in thymocytes was effectively blocked by ghrelin. Western blot analysis demonstrated that ghrelin prevents the cleavage of pro-apoptotic proteins such as Bim, Caspase-3, and PARP. In addition, ghrelin stimulation activates the Akt and Mitogen-activated protein kinases (MAPK) signaling pathways in a time/dose-dependent manner. Moreover, we also revealed the involvement of the FoxO3a pathway in the phosphorylation of Akt and ERK1/2. Together, these findings suggest that ghrelin inhibits apoptosis by modulating the stress-induced apoptotic signal pathway in the restraint-induced thymic apoptosis. PMID:27574503

  20. Evaluation of Life Sciences Glovebox (LSG) and Multi-Purpose Crew Restraint Concepts

    Science.gov (United States)

    Whitmore, Mihriban

    2005-01-01

    Within the scope of the Multi-purpose Crew Restraints for Long Duration Spaceflights project, funded by Code U, it was proposed to conduct a series of evaluations on the ground and on the KC-135 to investigate the human factors issues concerning confined/unique workstations, such as the design of crew restraints. The usability of multiple crew restraints was evaluated for use with the Life Sciences Glovebox (LSG) and for performing general purpose tasks. The purpose of the KC-135 microgravity evaluation was to: (1) to investigate the usability and effectiveness of the concepts developed, (2) to gather recommendations for further development of the concepts, and (3) to verify the validity of the existing requirements. Some designs had already been tested during a March KC-135 evaluation, and testing revealed the need for modifications/enhancements. This flight was designed to test the new iterations, as well as some new concepts. This flight also involved higher fidelity tasks in the LSG, and the addition of load cells on the gloveports.

  1. Metabotropic glutamate receptor-mediated signaling dampens the HPA axis response to restraint stress.

    Science.gov (United States)

    Evanson, Nathan K; Herman, James P

    2015-10-15

    Glutamate is an important neurotransmitter in the regulation of the neural portion of hypothalamus-pituitary-adrenal (HPA) axis activity, and signals through ionotropic and metabotropic receptors. In the current studies we investigated the role of hypothalamic paraventricular group I metabotropic glutamate receptors in the regulation of the HPA axis response to restraint stress in rats. Direct injection of the group I metabotropic glutamate receptor agonist 3,5-dihydroxyphenylglycine (DHPG) into the PVN prior to restraint leads to blunting of the HPA axis response in awake animals. Consistent with this result, infusion of the group I receptor antagonist hexyl-homoibotenic acid (HIBO) potentiates the HPA axis response to restraint. The excitatory effect of blocking paraventricular group I metabotropic glutamate signaling is blocked by co-administration of dexamethasone into the PVN. However, the inhibitory effect of DHPG is not affected by co-administration of the cannabinoid CB1 receptor antagonist AM-251 into the PVN. Together, these results suggest that paraventricular group I metabotropic glutamate receptor signaling acts to dampen HPA axis reactivity. This effect appears to be similar to the rapid inhibitory effect of glucocorticoids at the PVN, but is not mediated by endocannabinoid signaling.

  2. Evaluation of an evidence-based guidance on the reduction of physical restraints in nursing homes: a cluster-randomised controlled trial [ISRCTN34974819

    OpenAIRE

    Haastert Burkhard; Mühlhauser Ingrid; Gerlach Anja; Köpke Sascha; Haut Antonie; Meyer Gabriele

    2009-01-01

    Abstract Background Physical restraints are regularly applied in German nursing homes. Their frequency varies substantially between centres. Beneficial effects of physical restraints have not been proven, however, observational studies and case reports suggest various adverse effects. We developed an evidence-based guidance on this topic. The present study evaluates the clinical efficacy and safety of an intervention programme based on this guidance aimed to reduce physical restraints and min...

  3. Correlation between changes of central neurotransmitter expression and stress response in mice A restraint time-course analysis

    Institute of Scientific and Technical Information of China (English)

    Li Bao; Xinsheng Yao; Liang Zhao; Yanqing Lü; Hiroshi Kurihara

    2008-01-01

    BACKGROUND:Changes in central neurotransmitter expression play an important role in stress response and forms the basis for stress-induced psychological and behavior changes.OBJECTIVE:To observe the effects of different restraint stress intervals on brain monoamine neurotransmitter expression,and to investigate the correlation between stress response and neurotransmitter levels.DESIGN:Randomized controlled animal study.SETTING:Chinese Herb and Natural Medicine Institute,Pharmacological College of Jinan University.MATERIALS:Sixty 7-week-old male Kunming mice of clean grade,weighing 18-22 g,were provided by the Guangdong Medical Experimental Animal Center.The experiment was in accordance with animal ethics standards.METHODS:This study was performed at the Chinese Herb and Natural Medicine Institute,Pharmacological College of Jinan University from June 2006 to May 2007.A restraint device for mice was constructed according to published reports.Experimental mice were adaptively fed for 1 week and randomly divided into a control group(n=10)and an experimental group(n=50).The experimental group was sub-divided into five restraint intervals:4,8,12,18,and 24 hours(n=10 mice per time point).Animals in the experimental group were not allowed to eat or drink during the restraint period.Mice in the control group did not undergo restraint,but had identical food and water restrictions.Cerebral cortex and hypothalamus were separated based on observational times and protein was extracted using perchloric acid.Central monoamine neurotransmitter levels were measured using high performance liquid chromatography with electrochemical detection.MAIN OUTCOME MEASURES:Levels of norepinephrine(NE),dopamine hydrochloride(DA),3,4-dihydroxyphen-ylanetic acid (DOPAC),homovanillic acid(HVA),5-hydroxytryptamine(5-HT),and 5-hydroxyindoleac-etic acid(5-HIAA)in the cerebral cortex and hypothalamus of mice.RESULTS:Sixty mice were included in the final analysis.①NE levels in the cerebral

  4. Symmetric, coherent, Choquet capacities

    OpenAIRE

    Kadane, Joseph B.; Wasserman, Larry

    1996-01-01

    Choquet capacities are a generalization of probability measures that arise in robustness, decision theory and game theory. Many capacities that arise in robustness are symmetric or can be transformed into symmetric capacities. We characterize the extreme points of the set of upper distribution functions corresponding to coherent, symmetric Choquet capacities on [0, 1]. We also show that the set of 2-alternating capacities is a simplex and we give a Choquet representation of this set.

  5. Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging

    Directory of Open Access Journals (Sweden)

    Heather M Buechel

    2014-02-01

    Full Text Available Cognitive processes associated with prefrontal cortex and hippocampus decline with age and are vulnerable to disruption by stress. The stress/ stress hormone/ allostatic load hypotheses of brain aging posit that brain aging, at least in part, is the manifestation of life-long stress exposure. In addition, as humans age, there is a profound increase in the incidence of new onset stressors, many of which are psychosocial (e.g., loss of job, death of spouse, social isolation, and aged humans are well-understood to be more vulnerable to the negative consequences of such new-onset chronic psychosocial stress events. However, the mechanistic underpinnings of this age-related shift in chronic psychosocial stress response, or the initial acute phase of that chronic response, have been less well-studied. Here, we separated young (3 mo. and aged (21 mo. male F344 rats into control and acute restraint (an animal model of psychosocial stress groups (n = 9-12/ group. We then assessed hippocampus-associated behavioral, electrophysiological, and transcriptional outcomes, as well as blood glucocorticoid and sleep architecture changes. Aged rats showed characteristic water maze, deep sleep, transcriptome, and synaptic sensitivity changes compared to young. Young and aged rats showed similar levels of distress during the three hour restraint, as well as highly significant increases in blood glucocorticoid levels 21 hours after restraint. However, young, but not aged, animals responded to stress exposure with water maze deficits, loss of deep sleep and hyperthermia. These results demonstrate that aged subjects are hypo-responsive to new-onset acute psychosocial stress, which may have negative consequences for long-term stress adaptation and suggest that age itself may act as a stressor occluding the influence of new onset stressors.

  6. Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging.

    Science.gov (United States)

    Buechel, Heather M; Popovic, Jelena; Staggs, Kendra; Anderson, Katie L; Thibault, Olivier; Blalock, Eric M

    2014-01-01

    Cognitive processes associated with prefrontal cortex and hippocampus decline with age and are vulnerable to disruption by stress. The stress/stress hormone/allostatic load hypotheses of brain aging posit that brain aging, at least in part, is the manifestation of life-long stress exposure. In addition, as humans age, there is a profound increase in the incidence of new onset stressors, many of which are psychosocial (e.g., loss of job, death of spouse, social isolation), and aged humans are well-understood to be more vulnerable to the negative consequences of such new-onset chronic psychosocial stress events. However, the mechanistic underpinnings of this age-related shift in chronic psychosocial stress response, or the initial acute phase of that chronic response, have been less well-studied. Here, we separated young (3 month) and aged (21 month) male F344 rats into control and acute restraint (an animal model of psychosocial stress) groups (n = 9-12/group). We then assessed hippocampus-associated behavioral, electrophysiological, and transcriptional outcomes, as well as blood glucocorticoid and sleep architecture changes. Aged rats showed characteristic water maze, deep sleep, transcriptome, and synaptic sensitivity changes compared to young. Young and aged rats showed similar levels of distress during the 3 h restraint, as well as highly significant increases in blood glucocorticoid levels 21 h after restraint. However, young, but not aged, animals responded to stress exposure with water maze deficits, loss of deep sleep and hyperthermia. These results demonstrate that aged subjects are hypo-responsive to new-onset acute psychosocial stress, which may have negative consequences for long-term stress adaptation and suggest that age itself may act as a stressor occluding the influence of new onset stressors.

  7. Effects of acupuncture on behavioral, cardiovascular and hormonal responses in restraint-stressed Wistar rats

    Directory of Open Access Journals (Sweden)

    Guimarães C.M.

    1997-01-01

    Full Text Available Stress is a well-known entity and may be defined as a threat to the homeostasis of a being. In the present study, we evaluated the effects of acupuncture on the physiological responses induced by restraint stress. Acupuncture is an ancient therapeutic technique which is used in the treatment and prevention of diseases. Its proposed mechanisms of action are based on the principle of homeostasis. Adult male Wistar EPM-1 rats were divided into four groups: group I (N = 12, unrestrained rats with cannulas previously implanted into their femoral arteries for blood pressure and heart rate measurements; group II (N = 12, rats that were also cannulated and were submitted to 60-min immobilization; group III (N = 12, same as group II but with acupuncture needles implanted at points SP6, S36, REN17, P6 and DU20 during the immobilization period; group IV (N = 14, same as group III but with needles implanted at points not related to acupuncture (non-acupoints. During the 60-min immobilization period animals were assessed for stress-related behaviors, heart rate, blood pressure and plasma corticosterone, noradrenaline and adrenaline levels. Group III animals showed a significant reduction (60% on average, P<0.02 in restraint-induced behaviors when compared to groups II and IV. Data from cardiovascular and hormonal assessments indicated no differences between group III and group II and IV animals, but tended to be lower (50% reduction on average in group I animals. We hypothesize that acupuncture at points SP6, S36, REN17, P6 and DU20 has an anxiolytic effect on restraint-induced stress that is not due to a sedative action

  8. A restraint molecular dynamics and simulated annealing approach for protein homology modeling utilizing mean angles

    Directory of Open Access Journals (Sweden)

    Maurer Till

    2005-04-01

    Full Text Available Abstract Background We have developed the program PERMOL for semi-automated homology modeling of proteins. It is based on restrained molecular dynamics using a simulated annealing protocol in torsion angle space. As main restraints defining the optimal local geometry of the structure weighted mean dihedral angles and their standard deviations are used which are calculated with an algorithm described earlier by Döker et al. (1999, BBRC, 257, 348–350. The overall long-range contacts are established via a small number of distance restraints between atoms involved in hydrogen bonds and backbone atoms of conserved residues. Employing the restraints generated by PERMOL three-dimensional structures are obtained using standard molecular dynamics programs such as DYANA or CNS. Results To test this modeling approach it has been used for predicting the structure of the histidine-containing phosphocarrier protein HPr from E. coli and the structure of the human peroxisome proliferator activated receptor γ (Ppar γ. The divergence between the modeled HPr and the previously determined X-ray structure was comparable to the divergence between the X-ray structure and the published NMR structure. The modeled structure of Ppar γ was also very close to the previously solved X-ray structure with an RMSD of 0.262 nm for the backbone atoms. Conclusion In summary, we present a new method for homology modeling capable of producing high-quality structure models. An advantage of the method is that it can be used in combination with incomplete NMR data to obtain reasonable structure models in accordance with the experimental data.

  9. Reputational concerns, not altruism, motivate restraint when gambling with other people's money

    Directory of Open Access Journals (Sweden)

    Kodi B. Arfer

    2015-06-01

    Full Text Available People may behave prosocially not only because they value the welfare of others, but also to protect their own reputation. We examined the separate roles of altruism and reputational concerns in moral-hazard gambling tasks, which allowed subjects to gamble with a partner's money. In Study 1, subjects who were told that their partner would see their choices were more prosocial. In Study 2, subjects were more prosocial to a single partner when their choices were transparent than when their choices were attributed to a third party. We conclude that reputational concerns are a key restraint on selfish exploitation under moral hazard.

  10. Normal Mode Analysis with Molecular Geometry Restraints: Bridging Molecular Mechanics and Elastic Models

    OpenAIRE

    Lu, Mingyang; Ma, Jianpeng

    2011-01-01

    A new method for normal mode analysis is reported for all-atom structures using molecular geometry restraints (MGR). Similar to common molecular mechanics force fields, the MGR potential contains short- and long-range terms. The short-range terms are defined by molecular geometry, i.e. bond lengths, angles and dihedrals; the long-range term is similar to that in elastic network models. Each interaction term uses a single force constant parameter, and is determined by fitting against a set of ...

  11. DYNAMIC BEHAVIOR OF BURIED BEND WITH THRUST RESTRAINT IN LIQUEFYING GROUND

    Science.gov (United States)

    Kawabata, Toshinori; Sawada, Yutaka; Mohri, Yoshiyuki; Ling, Hoe I.

    In this study, a shaking table test was carried out in order to discuss the dynamic behavior for the bend of pressure pipeline with a concrete block and thrust restraints using geogrids or gravels in liquefying ground. As a result, it was revealed that the concrete block was largely moved and the relative displacement between the bend and the adjacent pipe became large. On the other hand, it was proved that geogrids and gravels were very effective for the lateral resistance in liquefying ground. In addition, the relative displacement was small because of the same difference between the bend and the adjacent pipe.

  12. Reducing use of restraints and seclusion to create a culture of safety.

    Science.gov (United States)

    Chandler, Genevieve E

    2012-10-01

    The purpose of this article is to describe the structure that empowered staff of a locked community hospital unit to reduce the use of restraints and seclusion to create a culture of safety. Themes garnered from interviews with and observations of key informants fit into the categories of a structural empowerment model, with leadership creating opportunities available for staff to develop new knowledge, information on trauma-informed care, support for feedback, and resources for the unit; thus, relationships with patients flourished. In turn, staff engaged in relationships with patients to provide opportunities to develop new knowledge and offer information, support, and resources.

  13. Reputational concerns, not altruism, motivate restraint when gambling with other people's money.

    Science.gov (United States)

    Arfer, Kodi B; Bixter, Michael T; Luhmann, Christian C

    2015-01-01

    People may behave prosocially not only because they value the welfare of others, but also to protect their own reputation. We examined the separate roles of altruism and reputational concerns in moral-hazard gambling tasks, which allowed subjects to gamble with a partner's money. In Study 1, subjects who were told that their partner would see their choices were more prosocial. In Study 2, subjects were more prosocial to a single partner when their choices were transparent than when their choices were attributed to a third party. We conclude that reputational concerns are a key restraint on selfish exploitation under moral hazard.

  14. Effects of acupuncture on behavioral, cardiovascular and hormonal responses in restraint-stressed Wistar rats

    OpenAIRE

    Guimarães C.M.; Pinge M.C.M.; Yamamura Y.; Mello L.E.A.M.

    1997-01-01

    Stress is a well-known entity and may be defined as a threat to the homeostasis of a being. In the present study, we evaluated the effects of acupuncture on the physiological responses induced by restraint stress. Acupuncture is an ancient therapeutic technique which is used in the treatment and prevention of diseases. Its proposed mechanisms of action are based on the principle of homeostasis. Adult male Wistar EPM-1 rats were divided into four groups: group I (N = 12), unrestrained rats wit...

  15. Restraint feeds stress: The relationship between eating disorder symptoms, stress generation, and the interpersonal theory of suicide.

    Science.gov (United States)

    Dodd, Dorian; Smith, April; Bodell, Lindsay

    2014-12-01

    Integrating research on stress generation and the interpersonal theory of suicide we examined whether eating disorder symptoms are related to stress generation and whether negative life events (stressors) contribute to feelings of burdensomeness and low belongingness. At two time points (approximately 1month apart), participants (n=186; 75% female) completed questionnaires measuring eating disorder symptoms, negative life events, burdensomeness, and belongingness. Regression analyses indicated that while controlling for depression, anxiety, and baseline frequency of negative events, dietary restraint significantly predicted negative events at follow-up. Dietary restraint indirectly influenced higher levels of perceived burdensomeness and low belongingness through its influence on negative events. Thus, dietary restraint may contribute to stress generation, and in turn exacerbate feelings of burdensomeness and low belongingness, two important constructs of the interpersonal theory of suicide. Greater understanding of these factors could lead to more effective and targeted suicide interventions for individuals who restrict food intake.

  16. Total iron binding capacity

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003489.htm Total iron binding capacity To use the sharing features on this page, please enable JavaScript. Total iron binding capacity (TIBC) is a blood test to ...

  17. Discontinuous symplectic capacities

    NARCIS (Netherlands)

    Zehmisch, K.; Ziltener, F.J.

    2014-01-01

    We show that the spherical capacity is discontinuous on a smooth family of ellipsoidal shells. Moreover, we prove that the shell capacity is discontinuous on a family of open sets with smooth connected boundaries.

  18. CDMA systems capacity engineering

    CERN Document Server

    Kim, Kiseon

    2004-01-01

    This new hands-on resource tackles capacity planning and engineering issues that are crucial to optimizing wireless communication systems performance. Going beyond the system physical level and investigating CDMA system capacity at the service level, this volume is the single-source for engineering and analyzing systems capacity and resources.

  19. Dietary restraint and subjective well-being in university students in Chile

    Directory of Open Access Journals (Sweden)

    Berta Schnettler

    2014-08-01

    Full Text Available Objective: To characterize university students typologies according to chronic food restriction, satisfaction with life and food consumption. Materials and method: A questionnaire was applied on a non-probability sample of 369 male and female students from five Chilean universities. The questionnaire included: Revised Restraint Scale (RRS, Satisfaction with Life Scale (SWLS, Satisfaction with Food-related Life (SWFL and the Health-related Quality of Life Index. The survey included food and drink consumption habits, weight and approximate height and sociodemographic variables. Results: Two factors in the RRS were detected by exploratory factor analysis: Preoccupation with Diet (PD and Weight fluctuations (WF. A confirmatory factor analysis validated the bifactor structure of the RRS with an acceptable adjustment kindness. The cluster analysis allowed a distinction of four typologies with a significant variation in PD, WF, SWLS and SWFL scoring, number of days with mental health problems, frequency of alcoholic drinks consumption, restraint on the consumption of certain foods, drinks and spices, consumption frequency of fruit out of the main meals and types. Typologies did not differ on their body mass index. Conclusions: Both, students preoccupied with diet and those who are not, experience higher levels of satisfaction with life and with food. Lower levels of global life satisfaction and satisfaction with food are related with the fluctuations in weight.

  20. Effect of glutathione on gastric mucosal lesion induced by restraint water-immersion in rats

    Institute of Scientific and Technical Information of China (English)

    Jun Li Wan; Chang Liu Wang

    2000-01-01

    AIM To determine the effect of glutathione (GSH) on stress gastric mucosal lesion.METHODS The stress gastric mucosal lesion as produced by restraint water-immersion in rats and gastricmucosal lesion, gastric mucosal GSH content, gastric acid secretion and gastric barrier mucus secretion wereexamined. We also observed the effect of GSH on gastric mucosal lesion and the effect of N-ethylmaleimine(NEM) and indomethacin on GSH protection. Comparisons between two groups were made using the Students t test.RESULTS GSH (100 and 200 mg/kg) intraperitoneally protected against stress gastric mucosal lesion(P0.05). The preinjection of NEM (10 mg/kg, sc.), a sulfhydryl-blocking reagent, or indomethacin(5 mg/kg, im.), a cyclooxygenase inhibitor, had no effect on protection of GSH (P>0.05). GSH(100mg/kg) significantly increased secretion of gastric barrier mucus (P0.05).CONCLUSION GSH can inhibit the formation of gastric mucosal lesions induced by restraint water-immersion. The protective effect of GSH was due, in part, to promoting the secretion of gastric barriermucus, but not to suppress the gastric acid secretion. The protection effect of GSH has no relation withgastric mucosal GSH and PGs.

  1. Variation in Behavioral Reactivity Is Associated with Cooperative Restraint Training Efficiency.

    Science.gov (United States)

    Bliss-Moreau, Eliza; Moadab, Gilda

    2016-01-01

    Training techniques that prepare laboratory animals to participate in testing via cooperation are useful tools that have the potential to benefit animal wellbeing. Understanding how animals systematically vary in their cooperative training trajectories will help trainers to design effective and efficient training programs. In the present report we document an updated method for training rhesus monkeys to cooperatively participate in restraint in a 'primate chair.' We trained 14 adult male macaques to raise their head above a yoke and accept yoke closure in an average of 6.36 training days in sessions that lasted an average of 10.52 min. Behavioral observations at 2 time points prior to training (approximately 3 y and 1.3 y prior) were used to quantify behavioral reactivity directed toward humans and toward other macaques. Individual differences in submissive-affiliative reactivity to humans but not reactivity toward other monkeys were related to learning outcomes. Macaques that were more reactive to humans were less willing to participate in training, were less attentive to the trainer, were more reactive during training sessions, and required longer training sessions, longer time to yoke, and more instances of negative reinforcement. These results suggest that rhesus macaques can be trained to cooperate with restraint rapidly and that individual difference data can be used to structure training programs to accommodate variation in animal temperament. PMID:26817979

  2. Characterization of pediatric wheelchair kinematics and wheelchair tiedown and occupant restraint system loading during rear impact.

    Science.gov (United States)

    Fuhrman, Susan I; Karg, Patricia; Bertocci, Gina

    2010-04-01

    This study characterizes pediatric wheelchair kinematic responses and wheelchair tiedown and occupant restraint system (WTORS) loading during rear impact. It also examines the kinematic and loading effects of wheelchair headrest inclusion in rear impact. In two separate rear-impact test scenarios, identical WC19-compliant manual pediatric wheelchairs were tested using a seated Hybrid III 6-year-old anthropomorphic test device (ATD) to evaluate wheelchair kinematics and WTORS loading. Three wheelchairs included no headrests, and three were equipped with slightly modified wheelchair-mounted headrests. Surrogate WTORS properly secured the wheelchairs; three-point occupant restraints properly restrained the ATD. All tests used a 26km/h, 11g rear-impact test pulse. Headrest presence affected wheelchair kinematics and WTORS loading; headrest-equipped wheelchairs had greater mean seatback deflections, mean peak front and rear tiedown loads and decreased mean lap belt loads. Rear-impact tiedown loads differed from previously measured loads in frontal impact, with comparable tiedown load levels reversed in frontal and rear impacts. The front tiedowns in rear impact had the highest mean peak loads despite lower rear-impact severity. These outcomes have implications for wheelchair and tiedown design, highlighting the need for all four tiedowns to have an equally robust design, and have implications in the development of rear-impact wheelchair transportation safety standards.

  3. The effect of current and anticipated body pride and shame on dietary restraint and caloric intake.

    Science.gov (United States)

    Troop, Nicholas A

    2016-01-01

    Studies have established a link between body shame and eating disorder symptoms and behaviours. However, few have differentiated current feelings of body shame from those anticipated with weight change and none has examined the effects of these on subsequent eating behaviour. In this paper, a measure of body pride and shame was developed (Study 1) for the purposes of using it in a subsequent longitudinal study (Study 2). Two hundred and forty two women were recruited from a university and the general population and participated in Study 1, completing the Body Pride and Shame (BPS) scale either online or offline, as well as a number of validating measures. In Study 2, 40 female students completed the BPS, as well as a measure of dietary restraint, and subsequently recorded their dietary intake everyday for the next seven days. Study 1 identified and validated subscales of current body pride/shame as well as pride/shame that is anticipated were the individual to gain weight or lose weight. In Study 2, over and above levels of dietary restraint, current feelings of body shame predicted eating more calories over the next 7 days while the anticipation of shame with weight gain predicted eating fewer calories. Although previous research has only measured current feelings of body shame, the present studies showed that anticipated shame also impacts on subsequent behaviour. Interventions that regulate anticipated as well as current emotions, and that do not merely challenge cognitions, may be important in changing eating behaviour. PMID:26456412

  4. Disruption of non-enzymatic antioxidant defense systems in the brain of rats with water-immersion restraint stress

    OpenAIRE

    Ohta, Yoshiji; Yashiro, Koji; Ohashi, Koji; Imai, Yoichiro

    2012-01-01

    We examined whether non-enzymatic antioxidant defense systems are disrupted in the brain of rats with water-immersion restraint stress. When rats were exposed to water-immersion restraint stress for 1.5, 3 or 6 h, the brain had decreased ascorbic acid and reduced glutathione contents and increased lipid peroxide and nitric oxide metabolites contents at 3 h and showed further changes in these components with a reduction of vitamin E content at 6 h. Increased serum levels of stress markers were...

  5. The Effects of an Action Plan, Staff Training, Management Support and Monitoring on Restraint Use and Costs of Work-Related Injuries

    Science.gov (United States)

    Sanders, Kim

    2009-01-01

    Background: Dignity and respect are at the foundation of good care and effective treatment planning and are guiding service principles. The use of physical restraints is contrary to treatment with dignity and respect. Because of the numerous risks to clients and employees associated with the use of physical restraints, an innovative plan was…

  6. Tests of the Aversive Summation Hypothesis in Rats: Effects of Restraint Stress on Consummatory Successive Negative Contrast and Extinction in the Barnes Maze

    Science.gov (United States)

    Ortega, Leonardo A.; Prado-Rivera, Mayerli A.; Cardenas-Poveda, D. Carolina; McLinden, Kristina A.; Glueck, Amanda C.; Gutierrez, German; Lamprea, Marisol R.; Papini, Mauricio R.

    2013-01-01

    The present research explored the effects of restraint stress on two situations involving incentive downshift: consummatory successive negative contrast (cSNC) and extinction of escape behavior in the Barnes maze. First, Experiment 1 confirmed that the restraint stress procedure used in these experiments increased levels of circulating…

  7. Capacity Statement for Railways

    DEFF Research Database (Denmark)

    Landex, Alex

    2007-01-01

    The subject “Railway capacity” is a combination of the capacity consumption and how the capacity is utilized. The capacity utilization of railways can be divided into 4 core elements: The number of trains; the average speed; the heterogeneity of the operation; and the stability. This article...... describes how the capacity consumption for railways can be worked out and analytical measurements of how the capacity is utilized. Furthermore, the article describes how it is possible to state and visualize railway capacity. Having unused railway capacity is not always equal to be able to operate more...... trains. This is due to network effects in the railway system and due to the fact that more trains results in lower punctuality....

  8. Chronic orthostatic and antiorthostatic restraint induce neuroendocrine, immune and neurophysiological disorders in rats

    Science.gov (United States)

    Assenmacher, I.; Mekaouche, M.; Maurel, D.; Barbanel, G.; Givalois, L.; Boissin, J.; Malaval, F.; Ixart, G.

    The tail-cast suspension rat model has been developed in ground laboratories interested in space physiology for extensive study of mechanisms causing the pathophysiological syndrome associated with space flights. We used individually-caged male rats to explore the effects of acute and chronic (7d) orthostatic restraint (OR) and head-down anti-orthostatic restraint (AOR) on a series of physiological variables. The acute restraint study showed that (1) the installation of the OR device induced an acute reaction for 2 days, with a substantial rise in ACTH (x2) and CORT (x6), and that (2) the head-down tilt from OR to AOR induced (i) within 10 min and lasting 60 min a 2-fold rise in the intra-cerebro-ventricular pressure (Picv) monitored with an icv telemetric recording system, which receded to normal between 60 and 120 min; and (ii) within 30 min a short-lived 4-fold rise in plasma ACTH and CORT levels. Chronic OR induced (1) the suppression of the diurnal ACTH/CORT rhythm, with increased mean levels, especially for ACTH, (2) a degraded circadian locomotor activity rhythm manifested by a significant reduction in the spectral power of the 24h periodicity and a concomitant emergence of shorter (ultradian) periodicities, (3) an associated, but less pronounced alteration of the diurnal rhythm in body temperature; and (4) a marked increase in baseline plasma levels of IL-1β and an increased reactivity in cytokine release following an E. coli endotoxin (LPS) challenge. AOR induced (1) a similar obliteration of the circadian ACTH/CORT rhythm, (2) the loss of close correlation between ACTH and CORT, (3) a generalized increase in baseline plasma IL-1β levels and (4) more extensive degradation of the arcadian periodicity for both locomotor activity and, to a lesser extent, body temperature, replaced by dominant spectral powers for ultradian periodicities (3 to 10h). In conclusion, both experimental paradigms — but AOR more than OR — caused a blockade of the arcadian

  9. The Latent Structure of Dietary Restraint, Body Dissatisfaction, and Drive for Thinness: A Series of Taxometric Analyses

    Science.gov (United States)

    Holm-Denoma, Jill M.; Richey, J. Anthony; Joiner, Thomas E., Jr.

    2010-01-01

    Although the latent structure of various eating disorders has been explored in previous studies, no published studies have examined the latent structure of theoretically relevant variables that have been shown to cut across eating disorder diagnoses. The current study examined 3 such variables (dietary restraint, body dissatisfaction, and drive…

  10. Chemical restraint: "Pharmakologische Ruhigstellung" zum Management aggressiven Verhaltens im stationären Bereich in Theorie und Praxis

    OpenAIRE

    Libal, Gerhard; Plener, Paul L; Fegert, Jörg M; Kölch, Michael

    2006-01-01

    "Chemical restraint" oder "Pharmakologische Ruhigstellung" (PR) ist eine wichtige Intervention beim Management von aggressiven Verhaltensweisen von stationär behandelten Kindern und Jugendlichen. PR sollte ausschließlich im Rahmen eines standardisierten Interventionsplanes zur Anwendung kommen. Die Grundprinzipien eines solchen Zugangs sind transparente Vereinbarungen mit allen Beteiligten zur schnellen, sicheren und personenunabhängigen Reduktion des Verhaltens, ohne dass dabei Folges...

  11. Dietary restraint and body mass change. A 3-year follow up study in a representative Dutch sample

    NARCIS (Netherlands)

    Strien, T. van; Herman, C.P.; Verheijden, M.W.

    2014-01-01

    Objective: To determine in a representative Dutch sample the association of dietary restraint, Concern for Dieting, and Weight Fluctuation with subsequent change in body mass index (BMI; in kg/m(2)) in addition to possible moderator effects of sex, level of education, age category, ethnicity, overwe

  12. Developmental Trajectories in Toddlers' Self-Restraint Predict Individual Differences in Executive Functions 14 Years Later: A Behavioral Genetic Analysis

    Science.gov (United States)

    Friedman, Naomi P.; Miyake, Akira; Robinson, JoAnn L.; Hewitt, John K.

    2011-01-01

    We examined whether self-restraint in early childhood predicted individual differences in 3 executive functions (EFs; inhibiting prepotent responses, updating working memory, and shifting task sets) in late adolescence in a sample of approximately 950 twins. At ages 14, 20, 24, and 36 months, the children were shown an attractive toy and told not…

  13. Changes in Physiologic Parameters and Effects of Hooding in Red-tailed Hawks ( Buteo jamaicensis ) During Manual Restraint.

    Science.gov (United States)

    Doss, Grayson A; Mans, Christoph

    2016-06-01

    Manual restraint in birds of prey is required for many veterinary and research procedures. To investigate the effects of handling stress on physiologic parameters in raptorial birds, 8 red-tailed hawks ( Buteo jamaicensis ) were manually restrained over a 15-minute period. Respiratory rate (RR), heart rate (HR), and cloacal temperature were monitored over time and recorded at defined intervals during the experiment. The effect of hooding on physiologic variables was also evaluated in a complete crossover design. Both RR and HR decreased significantly during the 15-minute restraint period (HR, -80 ± 101.4 beats/min [bpm], [P birds had significantly lower HRs and RRs at 15 minutes of restraint (HR: 232.5 ± 26 bpm, [P birds restrained without a hood (HR: 280 ± 74.1 bpm; RR: 51.5 ± 28.8 breaths/min). Cloacal temperature increased significantly in all manually restrained birds (+2.2 ± 0.7°C, [P birds. In this study of the effects of manual restraint on red-tailed hawks, hooding versus nonhooding amplified the decrease in HR and RR but had no effect on stress-induced hyperthermia. PMID:27315379

  14. Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study

    Directory of Open Access Journals (Sweden)

    Brooks Samantha J

    2011-11-01

    Full Text Available Abstract Background Previous Magnetic Resonance Imaging (MRI studies of people with anorexia nervosa (AN have shown differences in brain structure. This study aimed to provide preliminary extensions of this data by examining how different levels of appetitive restraint impact on brain volume. Methods Voxel based morphometry (VBM, corrected for total intracranial volume, age, BMI, years of education in 14 women with AN (8 RAN and 6 BPAN and 21 women (HC was performed. Correlations between brain volume and dietary restraint were done using Statistical Package for the Social Sciences (SPSS. Results Increased right dorsolateral prefrontal cortex (DLPFC and reduced right anterior insular cortex, bilateral parahippocampal gyrus, left fusiform gyrus, left cerebellum and right posterior cingulate volumes in AN compared to HC. RAN compared to BPAN had reduced left orbitofrontal cortex, right anterior insular cortex, bilateral parahippocampal gyrus and left cerebellum. Age negatively correlated with right DLPFC volume in HC but not in AN; dietary restraint and BMI predicted 57% of variance in right DLPFC volume in AN. Conclusions In AN, brain volume differences were found in appetitive, somatosensory and top-down control brain regions. Differences in regional GMV may be linked to levels of appetitive restraint, but whether they are state or trait is unclear. Nevertheless, these discrete brain volume differences provide candidate brain regions for further structural and functional study in people with eating disorders.

  15. The Contribution of Children's Temperamental Fear and Effortful Control to Restraint and Seclusion during Inpatient Treatment in a Psychiatric Hospital

    Science.gov (United States)

    Bridgett, David J.; Valentino, Kristin; Hayden, Lisa C.

    2012-01-01

    The current study examined temperament characteristics as risk factors for restraint and seclusion (R/S) events in psychiatrically hospitalized youth, extending work that has sought to identify R/S risk factors and research examining temperament-behavior problem associations that has largely relied upon community samples. It was anticipated that…

  16. Evaluation of railway capacity

    DEFF Research Database (Denmark)

    Landex, Alex; Kaas, Anders H.; Schittenhelm, Bernd;

    2006-01-01

    This paper describes the relatively new UIC 406 method for calculating capacity consumption on railway lines. The UIC 406 method is an easy and effective way of calculating the capacity consumption, but it is possible to expound the UIC 406 method in different ways which can lead to different...... of a railway network. Some of the aspects which have to be paid attention to making annual capacity statements are presented too....

  17. Nuclear Capacity Auctions

    OpenAIRE

    Fridolfsson, Sven-Olof; Tangerås, Thomas

    2011-01-01

    We propose nuclear capacity auctions as a means to improve the incentives for investing in nuclear power. A properly designed auction would (i) allocate the license to the most efficient bidder; (ii) sell the license if and only if new nuclear power was socially optimal. In particular, capacity auctions open the market for large-scale entry by outside firms. Requiring licensees to sell a share of capacity as virtual power plant contracts increases auction efficiency by softening incumbent pro...

  18. Capacity Building in Vietnam

    OpenAIRE

    Adam McCarty

    2001-01-01

    This report is the outcome of a study commissioned to examine the capacity building needs in Vietnam, and is a supplementary document to the Asian Development Bank's Country Operational Strategy for Vietnam. Vietnam's needs in terms of capacity building are particularly important given that is it a transitional economy and also one with little institutional experience in dealing with the international donor community. This paper examines the international awareness of capacity building and ca...

  19. The French capacity mechanism

    International Nuclear Information System (INIS)

    The French capacity mechanism has been design to ensure security of supply in the context of the energy transition. This energy transition challenges the electricity market design with several features: peak load growth, the development of renewables, demand response,... To ensure security of supply in this context, a capacity mechanism is being implemented in France. It is a market wide capacity obligation on electricity suppliers, based on market principles. Suppliers are responsible for forecasting their obligation, which corresponds to their contribution to winter peak load, and must procure enough capacity certificates to meet their obligations. Capacity certificates are granted to capacities through a certification process, which assesses their contribution to security of supply on the basis of availability commitments. This certification process is technology neutral and performance based, associated with controls and penalties in case of non compliance. Demand Side is fully integrated in the market, either through the reduction of suppliers' capacity obligation or direct participation after certification. In addition to the expected benefits in terms of security of supply, the French capacity market will foster the development of demand response. The participation of foreign capacities will require adaptations which are scheduled in a road-map, and could pave the way for further European integration of energy policies. (authors)

  20. Shortened constraint-induced movement therapy in subacute stroke - no effect of using a restraint

    DEFF Research Database (Denmark)

    Brogårdh, Christina; Vestling, Monika; Sjölund, Bengt H

    2009-01-01

    Scale, the Sollerman hand function test, the 2-Point Discrimination test and Motor Activity Log test. RESULTS: Patients in both groups showed significant improvements in arm and hand motor performance and on self-reported motor ability after 2 weeks of therapy and at 3 months follow-up. However......, no statistically significant differences between the groups were found in any measures at any point in time. CONCLUSION: In this study, no effect of using a restraint in patients with subacute stroke was found. Thus, this component in the constraint-induced therapy concept seems to be of minor importance......OBJECTIVE: To examine the effect of using a mitt during shortened constraint-induced movement therapy for patients in the subacute phase after stroke. SUBJECTS: Twenty-four patients with stroke (mean age 57.6 (standard deviation (SD) 8.5) years; average 7 weeks post-stroke) with mild to moderate...

  1. Issues in the Seclusion and Restraint of Juveniles: Policy, Practice and Possibilities

    Directory of Open Access Journals (Sweden)

    Rodney A. Ellis

    2001-05-01

    Full Text Available The appropriate use of seclusion and restraint (S/R is an important issue among juvenile justice professionals. Recent newspaper articles have brought the issue to the attention of the United States Senate, law enforcement agencies, and the general public. The result has been a series of investigations and publications by the Senate, law enforcement, and professional associations. Despite the attention this issue has received, professionals have yet to reach a definitive agreement as to what recent legislation and the professional and popular literature regarding the use of S/R. They identify major issues currently under discussion, highlight areas of consensus, and enumerate several dimensions that require further exploration. Finally, the authors discuss the implications of S/R for social work practitioners, including the importance of education and training, monitoring, hiring, policy advocacy, and ongoin research.

  2. The influence of individualized music on patients in physical restraints: a pilot study.

    Science.gov (United States)

    Janelli, Linda M; Kanski, Genevieve W; Wu, Yow-Wu Bill

    This pilot study explored the relationship between listening to preferred music and the behavioral responses of patients who are physically restrained. Thirty patients, ranging in age from 65 to 93, participated in one of three groups. The first group included patients who were out of restraining devices while listening to preferred music. Patients in the second group were out of restraining devices and not exposed to music. The third group comprised patients who were in restraining devices while listening to preferred music. Listening to preferred music had no significant effect on decreasing patients' negative behaviors or on increasing positive behaviors observed during the intervention phase of the study. The higher mean scores for positive behaviors and lower mean scores for negative behaviors for the first group may indicate some benefits to patients who are out of restraints and listening to preferred music.

  3. a Dosimetry Assessment for the Core Restraint of AN Advanced Gas Cooled Reactor

    Science.gov (United States)

    Thornton, D. A.; Allen, D. A.; Tyrrell, R. J.; Meese, T. C.; Huggon, A. P.; Whiley, G. S.; Mossop, J. R.

    2009-08-01

    This paper describes calculations of neutron damage rates within the core restraint structures of Advanced Gas Cooled Reactors (AGRs). Using advanced features of the Monte Carlo radiation transport code MCBEND, and neutron source data from core follow calculations performed with the reactor physics code PANTHER, a detailed model of the reactor cores of two of British Energy's AGR power plants has been developed for this purpose. Because there are no relevant neutron fluence measurements directly supporting this assessment, results of benchmark comparisons and successful validation of MCBEND for Magnox reactors have been used to estimate systematic and random uncertainties on the predictions. In particular, it has been necessary to address the known under-prediction of lower energy fast neutron responses associated with the penetration of large thicknesses of graphite.

  4. Clarification of abrasive jet precision finishing with wheel as restraint mechanisms and experimental verification

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    According to the critical size ratio for the characteristic particle size to film thickness between grinding wheel and work, the machining mechanisms in abrasive jet precision finishing with grinding wheel as restraint can be categorized into four states, namely, two-body lapping, three-body polishing, abrasive jet machining and fluid hydrodynamic shear stress machining. The critical transition condition of two-body lapping to three-body polishing was analyzed. The single abrasive material removal models of two-body lapping, three-body polishing, abrasive jet finishing and fluid hydrodynamic shear stress machining were proposed. Experiments were performed in the refited plane grinding machine for theoretical modes verification. It was found that experimental results agreed with academic modes and the modes validity was verified.

  5. Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice.

    Science.gov (United States)

    Zhu, Shenghua; Shi, Ruoyang; Wang, Junhui; Wang, Jun-Feng; Li, Xin-Min

    2014-10-01

    The chronic stress model was developed on the basis of the stress-diathesis hypothesis of depression. However, these behavioural responses associated with different stress paradigms are quite complex. This study examined the effects of two chronic stress regimens on anxiety-like and depressive behaviours. C57BL/6 mice were subjected to unpredictable chronic mild stress or to chronic restraint stress for 4 weeks. Subsequently, both anxiety-like behaviours (open field, elevated plus maze and novelty suppressed feeding) and depression-like behaviours (tail suspension, forced swim and sucrose preference) were evaluated. Both chronic stress models generated anxiety-like behaviours, whereas only unpredictable chronic mild stress could induce depressive behaviours such as increased immobility and decreased sucrose consumption. These results of the present study provide additional evidence on how chronic stress affects behavioural responses and point to the importance of the validity of animal models of chronic stress in studying depression. PMID:25089805

  6. Experimental Research on Tank Exhaust' s Thermal Restraint Based on Thermoelectric Generation Theory

    Institute of Scientific and Technical Information of China (English)

    毕小平; 周国印; 刘晓; 李义军

    2012-01-01

    Aimed at the high temperature of tank' s exhaust, the principle of applying thermoelectric generation technology to tank thermal restraint was analyzed. Its application experiments were conducted to test the exhaust temperature under dif- ferent rotating speeds, The experiment results show that the thermoelectric generator can output sufficient electric energy to drive fans; the external surface temperature'of radiator is reduced by over 65.0% compared with exhaust surface due to the combination effect of thermoelectric conversion, fan cooling and heat radiation ; the exhaust surface temperature rise caused by increase of the engine' s rotating speed results in the increases of the temperature difference of the thermoelectric genera- tor's cold and hot sides, the fan's driving voltage and heat convection, thus, the effect of fan's cooling is more obvious than that of the temperature rise caused by exhaust.

  7. Effects of genetic origin and social environment on behavioral response to manual restraint and monoamine functioning in laying hens.

    Science.gov (United States)

    Uitdehaag, K A; Rodenburg, T B; Van Reenen, C G; Koopmanschap, R E; De Vries Reilingh, G; Engel, B; Buist, W G; Komen, H; Bolhuis, J E

    2011-08-01

    Purebred laying hen lines of White Leghorn (WL) origin have been found to be more flighty and to show more feather pecking than lines of Rhode Island Red (RIR) origin. It has been found, however, that when RIR birds were housed together with WL birds, RIR birds became more flighty and those mixed groups developed more feather damage than pure-line cage-housed groups. It is unknown, however, whether this effect of social environment is accompanied by changes in stress-related behavior and neurophysiological activity, which are assumed to be associated with increased feather damage. The objective of this study was therefore to investigate the effects of genetic origin (WL or RIR) and social environment (mixed or pure groups) on behavioral response to manual restraint and monoamine functioning. Monoamine functioning was measured by brain serotonin (5-HT) and dopamine turnover. Furthermore, correlations between 5-HT turnover in the brain and peripheral measures of 5-HT in the blood were calculated. Experimental birds, housed either with other birds from the same genetic origin (pure groups) or with both RIR and WL birds (mixed groups) from hatching onward, were subjected to a manual restraint test at 47 wk of age. The WL birds struggled less during restraint and had higher dopamine and 5-HT turnover levels after restraint than did RIR birds. The WL birds also showed higher levels of platelet 5-HT uptake than did RIR birds. No effects of social environment were found. Blood and brain 5-HT measures were found to be correlated, with correlations ranging from 0.34 to 0.57, which seems to offer opportunities for less invasive peripheral indicators of 5-HT activity. In conclusion, genetic origin, but not social environment, affected the behavioral response to manual restraint and monoamine functioning in laying hens. PMID:21753196

  8. PURY: a database of geometric restraints of hetero compounds for refinement in complexes with macromolecular structures.

    Science.gov (United States)

    Andrejasic, Miha; Praaenikar, Jure; Turk, Dusan

    2008-11-01

    The number and variety of macromolecular structures in complex with ;hetero' ligands is growing. The need for rapid delivery of correct geometric parameters for their refinement, which is often crucial for understanding the biological relevance of the structure, is growing correspondingly. The current standard for describing protein structures is the Engh-Huber parameter set. It is an expert data set resulting from selection and analysis of the crystal structures gathered in the Cambridge Structural Database (CSD). Clearly, such a manual approach cannot be applied to the vast and ever-growing number of chemical compounds. Therefore, a database, named PURY, of geometric parameters of chemical compounds has been developed, together with a server that accesses it. PURY is a compilation of the whole CSD. It contains lists of atom classes and bonds connecting them, as well as angle, chirality, planarity and conformation parameters. The current compilation is based on CSD 5.28 and contains 1978 atom classes and 32,702 bonding, 237,068 angle, 201,860 dihedral and 64,193 improper geometric restraints. Analysis has confirmed that the restraints from the PURY database are suitable for use in macromolecular crystal structure refinement and should be of value to the crystallographic community. The database can be accessed through the web server http://pury.ijs.si/, which creates topology and parameter files from deposited coordinates in suitable forms for the refinement programs MAIN, CNS and REFMAC. In the near future, the server will move to the CSD website http://pury.ccdc.cam.ac.uk/.

  9. Female reproductive competition in Eulemur rufifrons: eviction and reproductive restraint in a plurally breeding Malagasy primate.

    Science.gov (United States)

    Kappeler, Peter M; Fichtel, Claudia

    2012-02-01

    In mammals with female philopatry, co-resident females inevitably compete with each other for resources or reproductive opportunities, thereby reducing the kin-selected benefits of altruism towards relatives. These counteracting forces of cooperation and competition among kin should be particularly pronounced in plurally breeding species with limited alternative breeding opportunities outside the natal group. However, little is still known about the costs of reproductive competition on females' fitness and the victims' potential counter-strategies. Here we summarize long-term behavioural, demographic and genetic data collected on a plurally breeding primate from Madagascar to illuminate mechanisms and effects of female reproductive competition, focusing on forcible eviction and potential reproductive restraint. The main results of our study indicate that females in groups of redfronted lemurs (Eulemur rufifrons) above a critical size suffer from competition from their close relatives: females in larger groups face an increased probability of not giving birth as well as a higher probability of being evicted, especially during the annual mating and birth seasons. Eviction is not predicted by the number of adult females, the number of close female relatives, female age or inter-annual variation in rainfall but only by total group size. Thus, eviction in this species is clearly linked with reproductive competition, it cannot be forestalled by reproductive restraint or having many relatives in the group, and it occurs in the absence of a clear dominance hierarchy. Our study therefore also underscores the notion that potential inclusive fitness benefits from living with relatives may have been generally over-rated and should not be taken for granted.

  10. Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.

    Science.gov (United States)

    Huang, Pengcheng; Li, Cai; Fu, Tianli; Zhao, Dan; Yi, Zhen; Lu, Qing; Guo, Lianjun; Xu, Xulin

    2015-07-15

    Chronic restraint stress (CRS) causes hippocampal neurodegeneration and hippocampus-dependent cognitive deficits. Flupirtine represents neuroprotective effects and we have previously shown that flupirtine can protect against memory impairment induced by acute stress. The present study aimed to investigate whether flupirtine could alleviate spatial learning and memory impairment and hippocampal apoptosis induced by CRS. CRS mice were restrained in well-ventilated Plexiglass tubes for 6h daily beginning from 10:00 to 16:00 for 21 consecutive days. Mice were injected with flupirtine (10mg/kg and 25mg/kg) or vehicle (10% DMSO) 30min before restraint stress for 21 days. After stressor cessation, the spatial learning and memory, dendritic spine density, injured neurons and the levels of Bcl-2, Bax, p-Akt, p-GSK-3β, p-Erk1/2 and synaptophysin of hippocampal tissues were examined. Our results showed that flupirtine significantly prevented spatial learning and memory impairment induced by CRS in the Morris water maze. In addition, flupirtine (10mg/kg and 25mg/kg) treatment alleviated neuronal apoptosis and the reduction of dendritic spine density and synaptophysin expression in the hippocampal CA1 region of CRS mice. Furthermore, flupirtine (10mg/kg and 25mg/kg) treatment significantly decreased the expression of Bax and increased the p-Akt and p-GSK-3β, and flupirtine (25mg/kg) treatment up-regulated the p-Erk1/2 in the hippocampus of CRS mice. These results suggested that flupirtine exerted protective effects on the CRS-induced cognitive impairment and hippocampal neuronal apoptosis, which is possibly associated with the activation of Akt/GSK-3β and Erk1/2 signaling pathways. PMID:25869780

  11. Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice

    International Nuclear Information System (INIS)

    Both radiation and stresses cause detrimental effects on humans. Besides possible health effects resulting directly from radiation exposure, the nuclear plant accident is a cause of social psychological stresses. A recent study showed that chronic restraint-induced stresses (CRIS) attenuated Trp53 functions and increased carcinogenesis susceptibility of Trp53-heterozygous mice to total-body X-irradiation (TBXI), having a big impact on the academic world and a sensational effect on the public, especially the residents living in radioactively contaminated areas. It is important to investigate the possible modification effects from CRIS on radiation-induced health consequences in Trp53 wild-type (Trp53wt) animals. Prior to a carcinogenesis study, effects of TBXI on the hematopoietic system under CRIS were investigated in terms of hematological abnormality in the peripheral blood and residual damage in the bone marrow erythrocytes using a mouse restraint model. Five-week-old male Trp53wt C57BL/6J mice were restrained 6 h per day for 28 consecutive days, and TBXI (4 Gy) was given on the 8th day. Results showed that CRIS alone induced a marked decrease in the red blood cell (RBC) and the white blood cell (WBC) count, while TBXI caused significantly lower counts of RBCs, WBCs and blood platelets, and a lower concentration of hemoglobin regardless of CRIS. CRIS alone did not show any significant effect on erythrocyte proliferation and on induction of micronucleated erythrocytes, whereas TBXI markedly inhibited erythrocyte proliferation and induced a significant increase in the incidences of micronucleated erythrocytes, regardless of CRIS. These findings suggest that CRIS does not have a significant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53wt mice. (author)

  12. Restraint stress-induced morphological changes at the blood-brain barrier in adult rats

    Directory of Open Access Journals (Sweden)

    Petra eSántha

    2016-01-01

    Full Text Available Stress is well known to contribute to the development of both neurological and psychiatric diseases. While the role of the blood-brain barrier is increasingly recognised in the development of neurodegenerative disorders, such as Alzheimer’s disease, dysfunction of the blood-brain barrier has been linked to stress-related psychiatric diseases only recently. In the present study the effects of restraint stress with different duration (1, 3 and 21 days were investigated on the morphology of the blood-brain barrier in male adult Wistar rats. Frontal cortex and hippocampus sections were immunostained for markers of brain endothelial cells (claudin-5, occludin and glucose transporter-1 and astroglia (GFAP. Staining pattern and intensity were visualized by confocal microscopy and evaluated by several types of image analysis. The ultrastructure of brain capillaries was investigated by electron microscopy. Morphological changes and intensity alterations in brain endothelial tight junction proteins claudin-5 and occludin were induced by stress. Following restraint stress significant increases in the fluorescence intensity of glucose transporter-1 were detected in brain endothelial cells in the frontal cortex and hippocampus. Significant reductions in GFAP fluorescence intensity were observed in the frontal cortex in all stress groups. As observed by electron microscopy, one-day acute stress induced morphological changes indicating damage in capillary endothelial cells in both brain regions. After 21 days of stress thicker and irregular capillary basal membranes in the hippocampus and edema in astrocytes in both regions were seen. These findings indicate that stress exerts time-dependent changes in the staining pattern of tight junction proteins occludin, claudin-5 and glucose transporter-1 at the level of brain capillaries and in the ultrastructure of brain endothelial cells and astroglial endfeet, which may contribute to neurodegenerative processes

  13. Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice.

    Science.gov (United States)

    Freitas, Andiara E; Bettio, Luis E B; Neis, Vivian B; Santos, Danúbia B; Ribeiro, Camille M; Rosa, Priscila B; Farina, Marcelo; Rodrigues, Ana Lúcia S

    2014-04-01

    Agmatine has been recently emerged as a novel candidate to assist the conventional pharmacotherapy of depression. The acute restraint stress (ARS) is an unavoidable stress situation that may cause depressive-like behavior in rodents. In this study, we investigated the potential antidepressant-like effect of agmatine (10mg/kg, administered acutely by oral route) in the forced swimming test (FST) in non-stressed mice, as well as its ability to abolish the depressive-like behavior and hippocampal antioxidant imbalance induced by ARS. Agmatine reduced the immobility time in the mouse FST (1-100mg/kg) in non-stressed mice. ARS caused an increase in the immobility time in the FST, indicative of a depressive-like behavior, as well as hippocampal lipid peroxidation, and an increase in the activity of hippocampal superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities, reduced catalase (CAT) activity and increased SOD/CAT ratio, an index of pro-oxidative conditions. Agmatine was effective to abolish the depressive-like behavior induced by ARS and to prevent the ARS-induced lipid peroxidation and changes in SOD, GR and CAT activities and in SOD/CAT activity ratio. Hippocampal levels of reduced glutathione (GSH) were not altered by any experimental condition. In conclusion, the present study shows that agmatine was able to abrogate the ARS-induced depressive-like behavior and the associated redox hippocampal imbalance observed in stressed restraint mice, suggesting that its antidepressant-like effect may be dependent on its ability to maintain the pro-/anti-oxidative homeostasis in the hippocampus.

  14. PURY: a database of geometric restraints of hetero compounds for refinement in complexes with macromolecular structures.

    Science.gov (United States)

    Andrejasic, Miha; Praaenikar, Jure; Turk, Dusan

    2008-11-01

    The number and variety of macromolecular structures in complex with ;hetero' ligands is growing. The need for rapid delivery of correct geometric parameters for their refinement, which is often crucial for understanding the biological relevance of the structure, is growing correspondingly. The current standard for describing protein structures is the Engh-Huber parameter set. It is an expert data set resulting from selection and analysis of the crystal structures gathered in the Cambridge Structural Database (CSD). Clearly, such a manual approach cannot be applied to the vast and ever-growing number of chemical compounds. Therefore, a database, named PURY, of geometric parameters of chemical compounds has been developed, together with a server that accesses it. PURY is a compilation of the whole CSD. It contains lists of atom classes and bonds connecting them, as well as angle, chirality, planarity and conformation parameters. The current compilation is based on CSD 5.28 and contains 1978 atom classes and 32,702 bonding, 237,068 angle, 201,860 dihedral and 64,193 improper geometric restraints. Analysis has confirmed that the restraints from the PURY database are suitable for use in macromolecular crystal structure refinement and should be of value to the crystallographic community. The database can be accessed through the web server http://pury.ijs.si/, which creates topology and parameter files from deposited coordinates in suitable forms for the refinement programs MAIN, CNS and REFMAC. In the near future, the server will move to the CSD website http://pury.ccdc.cam.ac.uk/. PMID:19020347

  15. Heat Capacity Analysis Report

    International Nuclear Information System (INIS)

    The purpose of this report is to provide heat capacity values for the host and surrounding rock layers for the waste repository at Yucca Mountain. The heat capacity representations provided by this analysis are used in unsaturated zone (UZ) flow, transport, and coupled processes numerical modeling activities, and in thermal analyses as part of the design of the repository to support the license application. Among the reports that use the heat capacity values estimated in this report are the ''Multiscale Thermohydrologic Model'' report, the ''Drift Degradation Analysis'' report, the ''Ventilation Model and Analysis Report, the Igneous Intrusion Impacts on Waste Packages and Waste Forms'' report, the ''Dike/Drift Interactions report, the Drift-Scale Coupled Processes (DST and TH Seepage) Models'' report, and the ''In-Drift Natural Convection and Condensation'' report. The specific objective of this study is to determine the rock-grain and rock-mass heat capacities for the geologic stratigraphy identified in the ''Mineralogic Model (MM3.0) Report'' (BSC 2004 [DIRS 170031], Table 1-1). This report provides estimates of the heat capacity for all stratigraphic layers except the Paleozoic, for which the mineralogic abundance data required to estimate the heat capacity are not available. The temperature range of interest in this analysis is 25 C to 325 C. This interval is broken into three separate temperature sub-intervals: 25 C to 95 C, 95 C to 114 C, and 114 C to 325 C, which correspond to the preboiling, trans-boiling, and postboiling regimes. Heat capacity is defined as the amount of energy required to raise the temperature of a unit mass of material by one degree (Nimick and Connolly 1991 [DIRS 100690], p. 5). The rock-grain heat capacity is defined as the heat capacity of the rock solids (minerals), and does not include the effect of water that exists in the rock pores. By comparison, the rock-mass heat capacity considers the heat capacity of both solids and pore

  16. Liquid heat capacity lasers

    Science.gov (United States)

    Comaskey, Brian J.; Scheibner, Karl F.; Ault, Earl R.

    2007-05-01

    The heat capacity laser concept is extended to systems in which the heat capacity lasing media is a liquid. The laser active liquid is circulated from a reservoir (where the bulk of the media and hence waste heat resides) through a channel so configured for both optical pumping of the media for gain and for light amplification from the resulting gain.

  17. Activation of the HPA axis and depression of feeding behavior induced by restraint stress are separately regulated by PACAPergic neurotransmission in the mouse.

    Science.gov (United States)

    Jiang, Sunny Zhihong; Eiden, Lee E

    2016-07-01

    We measured serum CORT elevation in wild-type and PACAP-deficient C57BL/6N male mice after acute (1 h) or prolonged (2-3 h) daily restraint stress for 7 d. The PACAP dependence of CORT elevation was compared to that of stress-induced hypophagia. Daily restraint induced unhabituated peak CORT elevation, and hypophagia/weight loss, of similar magnitude for 1, 2, and 3 h of daily restraint, in wild-type mice. Peak CORT elevation, and hypophagia, were both attenuated in PACAP-deficient mice for 2 and 3 h daily restraint. Hypophagia induced by 1-h daily restraint was also greatly reduced in PACAP-deficient mice, however CORT elevation, both peak and during recovery from stress, was unaffected. Thus, hypothalamic PACAPergic neurotransmission appears to affect CRH gene transcription and peptide production, but not CRH release, in response to psychogenic stress. A single exposure to restraint sufficed to trigger hypophagia over the following 24 h. PACAP deficiency attenuated HPA axis response (CORT elevation) to prolonged (3 h) but not acute (1 h) single-exposure restraint stress, while hypophagia induced by either a single 1 h or a single 3 h restraint were both abolished in PACAP-deficient mice. These results suggest that PACAP's actions to promote suppression of food intake following an episode of psychogenic stress is unrelated to the release of CRH into the portal circulation to activate the pituitary-adrenal axis. Furthermore, demonstration of suppressed food intake after a single 1-h restraint stress provides a convenient assay for investigating the location of the synapses and circuits mediating the effects of PACAP on the behavioral sequelae of psychogenic stress.

  18. Constraint - Induced Movement Therapy: Determinants and Correlates of Duration of Adherence to Restraint use Among Stroke Survivors with Hemiparesis

    Directory of Open Access Journals (Sweden)

    Arinola Olasumbo Sanya

    2012-02-01

    Full Text Available Background: Constraint-Induced Movement Therapy (CIMT was developed to improve purposeful movement of the stroke-affected extremity by restrictingthe use of the unaffected extremity. The two main components of CIMT are the training of the more-impaired arm to perform functional tasks, and the restraint of the less-impaired arm. One challenge that the application of CIMT faces is in ensuring adherence to the use of restraint.Purpose: There is a need to determine the factors that may influence adherence, as this would allow CIMT to be delivered more effectively, and prevent situations where unrealistic expectations are placed on stroke–affected individuals.Methods: Thirty stroke survivors with hemiparesis who met the inclusion criteria were consecutively recruited from the physiotherapy out-patient clinics, using a purposive sampling technique. A structured questionnaire was used to obtain information on clinical and socio-demographic parameters. The participants were given a restraint and an adherence time log-book, to make a daily record during the period they wore the restraint. The adherence time logbook was collected at the end of every week of the 3-week study. Motor function and functional use of the upper limb were measured using Motricity Index and Motor Activity Log respectively. Data was analysed using mean and standard deviations, independent t-test and Spearman rho; p was significant at 0.05.Results: Gender (p=0.73 and side affected/handedness (p=0.79 had no significant influence on the percentage duration of adherence to restraint use (DARU. The influence of socio-economic status was seen, with the participants of middle socio-economic status adhering for longer duration (p=0.02. Age had weak and no significant correlation with percentage DARU (p=0.55. There was significantly fair correlation between motor function/functional use at any stage (p=0.55 and the corresponding percentage duration of adherence to restraint use, except

  19. Visual attention capacity

    DEFF Research Database (Denmark)

    Habekost, Thomas; Starrfelt, Randi

    2009-01-01

    Psychophysical studies have identified two distinct limitations of visual attention capacity: processing speed and apprehension span. Using a simple test, these cognitive factors can be analyzed by Bundesen's Theory of Visual Attention (TVA). The method has strong specificity and sensitivity...

  20. Revisiting Absorptive Capacity

    DEFF Research Database (Denmark)

    de Araújo, Ana Luiza Lara; Ulhøi, John Parm; Lettl, Christopher

    Absorptive capacity has mostly been perceived as a 'passive' outcome of R&D investments. Recently, however, a growing interest into its 'proactive' potentials has emerged. This paper taps into this development and proposes a dynamic model for conceptualizing the determinants of the complementary...... learning processes of absorptive capacity, which comprise combinative and adaptive capabilities. Drawing on survey data (n=169), the study concludes that combinative capabilities primarily enhance transformative and exploratory learning processes, while adaptive capabilities strengthen all three learning...

  1. CO diffusion capacity

    Energy Technology Data Exchange (ETDEWEB)

    Mielke, U.

    1979-01-01

    We measured in 287 persons the pulmonary CO diffusion capacity with the steady-state and the single breath methods, applying apnoeic periods of 4 and 10 seconds duration. The aspects methodical significance, polyclinical applicability and pathognostic relevance with respect to other approved pulmonary functional tests are discussed. Differing pulmonary diffusion capacity values found in normal persons or in patients suffering from silicosis, pulmonary fibrosis, Boeck's disease or rheumatoid arthritis, were investigated and critically evaluated.

  2. Capacities in function theory

    OpenAIRE

    O'Farrell, Anthony G.

    1991-01-01

    Ever since the famous thesis of Frostman, capacities have been important in many areas of function theory. In this talk I shall be concerned only with one–variable function theory on arbitrary open subsets of the complex plane, C. It is important to stress that the open sets need not be connected. I will discuss the use of analytic capacities in connection with problems of removable singularities, holomorphic approximation, and boundary smoothness. A brief reference to the applications ...

  3. Specific 13C labeling of leucine, valine and isoleucine methyl groups for unambiguous detection of long-range restraints in protein solid-state NMR studies.

    Science.gov (United States)

    Fasshuber, Hannes Klaus; Demers, Jean-Philippe; Chevelkov, Veniamin; Giller, Karin; Becker, Stefan; Lange, Adam

    2015-03-01

    Here we present an isotopic labeling strategy to easily obtain unambiguous long-range distance restraints in protein solid-state NMR studies. The method is based on the inclusion of two biosynthetic precursors in the bacterial growth medium, α-ketoisovalerate and α-ketobutyrate, leading to the production of leucine, valine and isoleucine residues that are exclusively (13)C labeled on methyl groups. The resulting spectral simplification facilitates the collection of distance restraints, the verification of carbon chemical shift assignments and the measurement of methyl group dynamics. This approach is demonstrated on the type-three secretion system needle of Shigella flexneri, where 49 methyl-methyl and methyl-nitrogen distance restraints including 10 unambiguous long-range distance restraints could be collected. By combining this labeling scheme with ultra-fast MAS and proton detection, the assignment of methyl proton chemical shifts was achieved.

  4. Protein structure prediction guided by cross-linking restraints - A systematic evaluation of the impact of the cross-linking spacer length

    CERN Document Server

    Hofmann, Tommy; Meiler, Jens; Kalkhof, Stefan

    2015-01-01

    Recent development of high-resolution mass spectrometry (MS) instruments enables chemical cross-linking (XL) to become a high-throughput method for obtaining structural information about proteins. Restraints derived from XL-MS experiments have been used successfully for structure refinement and protein-protein docking. However, one formidable question is under which circumstances XL-MS data might be sufficient to determine a protein's tertiary structure de novo? Answering this question will not only include understanding the impact of XL-MS data on sampling and scoring within a de novo protein structure prediction algorithm, it must also determine an optimal cross-linker type and length for protein structure determination. While a longer cross-linker will yield more restraints, the value of each restraint for protein structure prediction decreases as the restraint is consistent with a larger conformational space. In this study, the number of cross-links and their discriminative power was systematically analyz...

  5. Specific 13C labeling of leucine, valine and isoleucine methyl groups for unambiguous detection of long-range restraints in protein solid-state NMR studies

    Science.gov (United States)

    Fasshuber, Hannes Klaus; Demers, Jean-Philippe; Chevelkov, Veniamin; Giller, Karin; Becker, Stefan; Lange, Adam

    2015-03-01

    Here we present an isotopic labeling strategy to easily obtain unambiguous long-range distance restraints in protein solid-state NMR studies. The method is based on the inclusion of two biosynthetic precursors in the bacterial growth medium, α-ketoisovalerate and α-ketobutyrate, leading to the production of leucine, valine and isoleucine residues that are exclusively 13C labeled on methyl groups. The resulting spectral simplification facilitates the collection of distance restraints, the verification of carbon chemical shift assignments and the measurement of methyl group dynamics. This approach is demonstrated on the type-three secretion system needle of Shigella flexneri, where 49 methyl-methyl and methyl-nitrogen distance restraints including 10 unambiguous long-range distance restraints could be collected. By combining this labeling scheme with ultra-fast MAS and proton detection, the assignment of methyl proton chemical shifts was achieved.

  6. Neuronal and inducible nitric oxide synthase upregulation in the rat medial prefrontal cortex following acute restraint stress: A dataset

    Directory of Open Access Journals (Sweden)

    Jereme G. Spiers

    2016-03-01

    Full Text Available This data article provides additional evidence on gene expression changes in the neuronal and inducible isoforms of nitric oxide synthase in the medial prefrontal cortex following acute stress. Male Wistar rats aged 6–8 weeks were exposed to control or restraint stress conditions for up to four hours in the dark cycle after which the brain was removed and the medial prefrontal cortex isolated by cryodissection. Following RNA extraction and cDNA synthesis, gene expression data were measured using quantitative real-time PCR. The mRNA levels of the neuronal and inducible nitric oxide synthase isoforms, and the inhibitory subunit of NF-κB, I kappa B alpha were determined using the ΔΔCT method relative to control animals. This data article presents complementary results related to the research article entitled ‘Acute restraint stress induces specific changes in nitric oxide production and inflammatory markers in the rat hippocampus and striatum’ [1].

  7. Development methods of guidelines and documents with recommendations on physical restraint reduction in nursing homes: a systematic review

    OpenAIRE

    Möhler, Ralph; Meyer, Gabriele

    2015-01-01

    Background Physical restraint, e.g. bedrails or belts in beds or chairs, are commonly used in nursing homes. However, there have been reports of pronounced differences in the prevalence between different facilities. Guidelines or other documents with recommendations for clinical practice are one approach to overcome centre variation and improve the quality of care. Rigorous development methods are deemed to ensure the validity, clarity and clinical applicability of practice recommendations. T...

  8. Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress.

    Science.gov (United States)

    Liang, S; Wang, T; Hu, X; Luo, J; Li, W; Wu, X; Duan, Y; Jin, F

    2015-12-01

    Increasing numbers of studies have suggested that the gut microbiota is involved in the pathophysiology of stress-related disorders. Chronic stress can cause behavioral, cognitive, biochemical, and gut microbiota aberrations. Gut bacteria can communicate with the host through the microbiota-gut-brain axis (which mainly includes the immune, neuroendocrine, and neural pathways) to influence brain and behavior. It is hypothesized that administration of probiotics can improve chronic-stress-induced depression. In order to examine this hypothesis, the chronic restraint stress depression model was established in this study. Adult specific pathogen free (SPF) Sprague-Dawley rats were subjected to 21 days of restraint stress followed by behavioral testing (including the sucrose preference test (SPT), elevated-plus maze test, open-field test (OFT), object recognition test (ORT), and object placement test (OPT)) and biochemical analysis. Supplemental Lactobacillus helveticus NS8 was provided every day during stress until the end of experiment, and selective serotonin reuptake inhibitor (SSRI) citalopram (CIT) served as a positive control. Results showed that L. helveticus NS8 improved chronic restraint stress-induced behavioral (anxiety and depression) and cognitive dysfunction, showing an effect similar to and better than that of CIT. L. helveticus NS8 also resulted in lower plasma corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels, higher plasma interleukin-10 (IL-10) levels, restored hippocampal serotonin (5-HT) and norepinephrine (NE) levels, and more hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression than in chronic stress rats. Taken together, these results indicate an anti-depressant effect of L. helveticus NS8 in rats subjected to chronic restraint stress depression and that this effect could be due to the microbiota-gut-brain axis. They also suggest the therapeutic potential of L. helveticus NS8 in stress-related and possibly other

  9. 49 CFR 571.202a - Standard No. 202a; Head restraints; Mandatory applicability begins on September 1, 2009.

    Science.gov (United States)

    2010-10-01

    ... in S3, S5, S5.1, S5.1.1, S5.2, S5.2.1, S5.2.2, and S5.2.7 of this section. The Director of the... dummy specified in 49 CFR part 572, subpart E, the applicable head restraint must conform to S4.2 of... positions. (1) Except as provided in S4.2.1(a)(2) of this section, when measured in accordance with......

  10. 49 CFR 571.202 - Standard No. 202; Head restraints; Applicable at the manufacturers option until September 1, 2009.

    Science.gov (United States)

    2010-10-01

    ... amplitude of 94 m/s2 and a duration of 96 milliseconds. S5.2Compliance with S4.2(b) of this section is... make/model. S5. Demonstration procedures. S5.1Compliance with S4.2(a) of this section is demonstrated.... S1. Purpose and scope. This standard specifies requirements for head restraints to reduce...

  11. electronic Ligand Builder and Optimisation Workbench (eLBOW): A tool for ligand coordinate and restraint generation

    Energy Technology Data Exchange (ETDEWEB)

    Moriarty, Nigel; Grosse-Kunstleve, Ralf; Adams, Paul

    2009-07-01

    The electronic Ligand Builder and Optimisation Workbench (eLBOW) is a program module of the PHENIX suite of computational crystallographic software. It's designed to be a flexible procedure using simple and fast quantum chemical techniques to provide chemically accurate information for novel and known ligands alike. A variety of input formats and options allow for the attainment of a number of diverse goals including geometry optimisation and generation of restraints.

  12. Contribution of social isolation, restraint, and hindlimb unloading to changes in hemodynamic parameters and motion activity in rats.

    Directory of Open Access Journals (Sweden)

    Darya Tsvirkun

    Full Text Available The most accepted animal model for simulation of the physiological and morphological consequences of microgravity on the cardiovascular system is one of head-down hindlimb unloading. Experimental conditions surrounding this model include not only head-down tilting of rats, but also social and restraint stresses that have their own influences on cardiovascular system function. Here, we studied levels of spontaneous locomotor activity, blood pressure, and heart rate during 14 days under the following experimental conditions: cage control, social isolation in standard rat housing, social isolation in special cages for hindlimb unloading, horizontal attachment (restraint, and head-down hindlimb unloading. General activity and hemodynamic parameters were continuously monitored in conscious rats by telemetry. Heart rate and blood pressure were both evaluated during treadmill running to reveal cardiovascular deconditioning development as a result of unloading. The main findings of our work are that: social isolation and restraint induced persistent physical inactivity, while unloading in rats resulted in initial inactivity followed by normalization and increased locomotion after one week. Moreover, 14 days of hindlimb unloading showed significant elevation of blood pressure and slight elevation of heart rate. Hemodynamic changes in isolated and restrained rats largely reproduced the trends observed during unloading. Finally, we detected no augmentation of tachycardia during moderate exercise in rats after 14 days of unloading. Thus, we concluded that both social isolation and restraint, as an integral part of the model conditions, contribute essentially to cardiovascular reactions during head-down hindlimb unloading, compared to the little changes in the hydrostatic gradient.

  13. Anti-Stress Effects of Carnosine on Restraint-Evoked Immunocompromise in Mice through Spleen Lymphocyte Number Maintenance

    OpenAIRE

    Yi-Fang Li; Rong-Rong He; Bun Tsoi; Xiao-Di Li; Wei-Xi Li; Keiichi Abe; Hiroshi Kurihara

    2012-01-01

    Carnosine (β-alanyl-L-histidine), a naturally occurring dipeptide, has been characterized as a putative neurotransmitter and serves as a reservoir for brain histamine, which could act on histaminergic neurons system to relieve stress-induced damages. However, understanding of the role of carnosine in stress-evoked immunocompromise is limited. In this study, results showed that when mice were subjected to restraint stress, spleen index and the number of spleen lymphocytes including Natural Kil...

  14. Electroacupuncture pretreatment exhibits anti-depressive effects by regulating hippocampal proteomics in rats with chronic restraint stress

    Institute of Scientific and Technical Information of China (English)

    Zhuo Guo; Xu-hui Zhang; Ya Tu; Tian-wei Guo; Yun-chu Wu; Xue-qin Yang; Lan Sun; Xin-jing Yang; Wen-yue Zhang; Yu Wang

    2015-01-01

    The clinical effect of electroacupuncture on depression is widely recognized. However, the signal transduction pathways and target proteins involved remain unclear. In the present study, rat models of chronic restraint stress were used to explore the mechanism by which electroacupuncture alleviates depression. Rats were randomly divided into control, model, and electroacupuncture groups. Chronic restraint stress was induced in the model and elec-troacupuncture groups by restraining rats for 28 days. In the electroacupuncture group, electroacupuncture pretreatment atBaihui (GV20) andYintang (GV29) acupoints was per-formed daily (1 mA, 2 Hz, discontinuous wave, 20 minutes) prior to restraint for 28 days. Open ifeld tests and body weight measurements were carried out to evaluate the depressive symptoms at speciifc time points. On day 28, the crossing number, rearing number, and body weights of the model group were signiifcantly lower than those in the control group. Behavior test results indicated that rat models of depressive-like symptoms were successfully established by chronic restraint stress combined with solitary raising. On day 28, an isobaric tag for a relative and abso-lute quantitation-based quantitative proteomic approach was performed to identify differentially expressed proteins in hippocampal samples obtained from the model and electroacupuncture groups. The potential function of these differential proteins was predicted through the use of the Cluster of Orthologous Groups of proteins (COG) database. Twenty-seven differential pro-teins (uncharacteristic proteins expected) were selected from the model and electroacupuncture groups. In addition to unknown protein functions, COG are mainly concentrated in general prediction function, mechanism of signal transduction, amino acid transport and metabolism groups. This suggests that electroacupuncture improved depressive-like symptoms by regulating differential proteins, and most of these related proteins

  15. Attenuation of Acute and Chronic Restraint Stress-induced Perturbations in Experimental Animals by Nelumbo nucifera Gaertn

    OpenAIRE

    Kulkarni, M. P.; Juvekar, A. R.

    2008-01-01

    Aqueous extract of leaves of Nelumbo nucifera was investigated on acute stress (immobilization stress)-induced biochemical alterations in Swiss mice. The animals were also subjected to acute physical stress (swimming endurance test) and acute chemical stress (writhing test) to gauge the antistress potential of the extract. Further to evaluate the antistress activity of Nelumbo nucifera in chronic stress condition, fresh Wistar rats were subjected to cold restraint stress (4° for 1 h) for 7 da...

  16. Attenuation of acute and chronic restraint stress-induced perturbations in experimental animals by Nelumbo nucifera Gaertn

    OpenAIRE

    Kulkarni M; Juvekar A

    2008-01-01

    Aqueous extract of leaves of Nelumbo nucifera was investigated on acute stress (immobilization stress)-induced biochemical alterations in Swiss mice. The animals were also subjected to acute physical stress (swimming endurance test) and acute chemical stress (writhing test) to gauge the antistress potential of the extract. Further to evaluate the antistress activity of Nelumbo nucifera in chronic stress condition, fresh Wistar rats were subjected to cold restraint stress (4° for 1 h) f...

  17. The Role of Inhibition in Age-related Off-Topic Verbosity: Not Access but Deletion and Restraint Functions

    OpenAIRE

    Yin, Shufei; Peng, Huamao

    2016-01-01

    The speech of older adults is commonly described as verbose and off-topic, which is thought to influence their social communication. This study investigated the role of inhibition in age-related off-topic verbosity (OTV). Inhibition consists of three functions: access, deletion, and restraint. The access function is responsible for preventing irrelevant information from accessing the attention center (pre-mechanism of inhibition); The deletion function is responsible for deleting previously r...

  18. Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress.

    Science.gov (United States)

    Liang, S; Wang, T; Hu, X; Luo, J; Li, W; Wu, X; Duan, Y; Jin, F

    2015-12-01

    Increasing numbers of studies have suggested that the gut microbiota is involved in the pathophysiology of stress-related disorders. Chronic stress can cause behavioral, cognitive, biochemical, and gut microbiota aberrations. Gut bacteria can communicate with the host through the microbiota-gut-brain axis (which mainly includes the immune, neuroendocrine, and neural pathways) to influence brain and behavior. It is hypothesized that administration of probiotics can improve chronic-stress-induced depression. In order to examine this hypothesis, the chronic restraint stress depression model was established in this study. Adult specific pathogen free (SPF) Sprague-Dawley rats were subjected to 21 days of restraint stress followed by behavioral testing (including the sucrose preference test (SPT), elevated-plus maze test, open-field test (OFT), object recognition test (ORT), and object placement test (OPT)) and biochemical analysis. Supplemental Lactobacillus helveticus NS8 was provided every day during stress until the end of experiment, and selective serotonin reuptake inhibitor (SSRI) citalopram (CIT) served as a positive control. Results showed that L. helveticus NS8 improved chronic restraint stress-induced behavioral (anxiety and depression) and cognitive dysfunction, showing an effect similar to and better than that of CIT. L. helveticus NS8 also resulted in lower plasma corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels, higher plasma interleukin-10 (IL-10) levels, restored hippocampal serotonin (5-HT) and norepinephrine (NE) levels, and more hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression than in chronic stress rats. Taken together, these results indicate an anti-depressant effect of L. helveticus NS8 in rats subjected to chronic restraint stress depression and that this effect could be due to the microbiota-gut-brain axis. They also suggest the therapeutic potential of L. helveticus NS8 in stress-related and possibly other

  19. How Do Light and Intermittent Smokers Differ from Heavy Smokers in Young Adulthood: The Role of Smoking Restraint Strategies.

    Science.gov (United States)

    Thrul, Johannes; Ferguson, Stuart G; Bühler, Anneke

    2016-01-01

    Light and intermittent smoking has become a prevalent pattern of use among young adults. Little is known about which factors differentiate light and intermittent smokers (LITS) from heavy smokers (HS) in young adulthood. In this study, we compare young adult LITS with HS with regard to demographic- and smoking-related variables, self-control abilities, and concrete strategies of smoking restraint. The data were collected as part of an Ecological Momentary Assessment (EMA) study with 137 German young adult smokers (M Age = 21.1 years, 46.0% female; 76 HS [≥10 cigarettes/day] and 61 LITS [≤5 cigarettes/day]). Participants were recruited over the Internet and completed a baseline questionnaire online. Several variables differentiated LITS and HS in a multiple logistic regression analysis: LITS reported fewer smoking friends (p smoking (p smoking status was associated with reporting a past quit attempt (p smoking restraint strategies (counting, limiting, and purposefully not smoking cigarettes; p smoking restraint strategies and self-monitoring of smoking to limit the daily number of cigarettes smoked.

  20. Characteristics of patients frequently subjected to pharmacological and mechanical restraint--a register study in three Norwegian acute psychiatric wards.

    Science.gov (United States)

    Knutzen, Maria; Bjørkly, Stål; Eidhammer, Gunnar; Lorentzen, Steinar; Mjøsund, Nina Helen; Opjordsmoen, Stein; Sandvik, Leiv; Friis, Svein

    2014-01-30

    This retrospective study from three catchment-area-based acute psychiatric wards showed that of all the pharmacologically and mechanically restrained patients (n=373) 34 (9.1%) had been frequently restrained (6 or more times). These patients accounted for 39.2% of all restraint episodes during the two-year study period. Adjusted binary logistic regression analyses showed that the odds for being frequently restrained were 91% lower among patients above 50 years compared to those aged 18-29 years; a threefold increase (OR=3.1) for those admitted 3 times or more compared to patients with only one stay; and, finally, a threefold increase (OR=3.1) if the length of stay was 16 days or more compared to those admitted for 0-4 days. Among frequently restrained patients, males (n=15) had significantly longer stays than women (n=19), and 8 of the females had a diagnosis of personality disorder, compared to none among males. Our study showed that being frequently restrained was associated with long inpatient stay, many admissions and young age. Teasing out patient characteristics associated with the risk of being frequently restraint may contribute to reduce use of restraint by developing alternative interventions for these patients.

  1. Influence of dietary restraint and environmental factors on meal size in normal-weight women. A laboratory study.

    Science.gov (United States)

    Bellisle, France; Dalix, Anne-Marie; Airinei, Gheorghe; Hercberg, Serge; Péneau, Sandrine

    2009-12-01

    In a previous study, we observed that the level of dietary restraint in normal-weight women moderated the stimulating effect of environmental stimuli on meal intake. The present study was designed to confirm and extend this observation. The influence of factors previously shown to affect meal size was investigated: presence of other people, television viewing and listening to radio. Two groups of 20 women were recruited, characterized by high versus low restraint. They participated in five standardised ad libitum lunches, under controlled laboratory conditions: subjects ate alone; in groups; listening to a detective story on the radio; watching television (no food cues); watching food advertisements on television. Lunches had identical menu (main dish and dessert) and were scheduled at 1-week intervals. Visual analogue scales were used to assess hunger, fullness and test-meal palatability. Repeated measures ANOVAs revealed no significant main effect of level of restraint and no interaction with meal conditions. Energy and main dish intakes were lower in the group meal condition than in the other four, which did not significantly differ. Group meals were followed by less intense fullness than the other conditions. These observations raise questions about the factors affecting social influence at meal times; gender, level of acquaintance and inhibitory norm are discussed. Our results also suggest that the intake stimulating effects of various external sources of distraction at meal time could vary in different populations. PMID:19619596

  2. European methodology of analysis vertical restraints under rule of reason in context of cooperative relation specific investments

    Directory of Open Access Journals (Sweden)

    Agamirova Maria, Е.

    2015-06-01

    Full Text Available The problem of underinvestment in specific assets is a key issue in new institutional economics, especially in case of cooperative relation specific investments. It can be solved due to vertical restraints, as an alternative way of vertical integration to transfer control to partner, who makes relation specific investments. The type of relationspecific investments called «cooperative» investments (or cross investments was nearly absent in economic analysis up to the very end of the twentieth century despite of the fact that such investments are widespread. It led to the absence of analysis relation specific investments in official regulation documents. At the same time, different types of relation specific investments can be characterized by different degree of riskiness and need special regulations of vertical agreements. In the paper author makes an attempt to analyze the European methodology of assessment vertical restraints under rule of reason focusing on the type of relation specific investments. It makes possible to improve analysis of vertical restraint in Russian antitrust.

  3. The rewards of restraint in the collective regulation of foraging by harvester ant colonies.

    Science.gov (United States)

    Gordon, Deborah M

    2013-06-01

    Collective behaviour, arising from local interactions, allows groups to respond to changing conditions. Long-term studies have shown that the traits of individual mammals and birds are associated with their reproductive success, but little is known about the evolutionary ecology of collective behaviour in natural populations. An ant colony operates without central control, regulating its activity through a network of local interactions. This work shows that variation among harvester ant (Pogonomyrmex barbatus) colonies in collective response to changing conditions is related to variation in colony lifetime reproductive success in the production of offspring colonies. Desiccation costs are high for harvester ants foraging in the desert. More successful colonies tend to forage less when conditions are dry, and show relatively stable foraging activity when conditions are more humid. Restraint from foraging does not compromise a colony's long-term survival; colonies that fail to forage at all on many days survive as long, over the colony's 20-30-year lifespan, as those that forage more regularly. Sensitivity to conditions in which to reduce foraging activity may be transmissible from parent to offspring colony. These results indicate that natural selection is shaping the collective behaviour that regulates foraging activity, and that the selection pressure, related to climate, may grow stronger if the current drought in their habitat persists.

  4. Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress.

    Science.gov (United States)

    Ding, Qin; Li, Hongxia; Tian, Xue; Shen, Zhilei; Wang, Xiaoli; Mo, Fengfeng; Huang, Junlong; Shen, Hui

    2016-06-01

    Depression is a common psychopathological disorders. Studies of depression have indicated that zinc play a role in the depression pathophysiology and treatment. In present study, we examined the effects of zinc and imipramine supplement alone or combination of zinc and imipramine in mice induced by chronic restraint stress (CRS). Moreover, the possible roles of zinc receptor (G protein-coupled receptor 39, GPR39)-related pathway was investigated. Decreased weight and increased corticosterone (CORT) were observed after 3 weeks CRS exposure. It was shown that CRS induced lower serum zinc, higher hippocampal zinc, increased immobility time in tail suspension test and decreased movement distance in spontaneous activity test, which could be normalized by zinc (30mg/kg) and imipramine (20mg/kg) supplement alone and combination of zinc (15mg/kg) and imipramine (5mg/kg) for 3 weeks after CRS exposure. Moreover, the changes in mRNA expressions of GPR39, cAMP-response element binding protein (CREB), brain-derived neurotropic factor (BDNF) and n-methytl-d-aspartate receptors (NMDAR) could be reversed by the same treatment mentioned above. These results suggested that zinc dyshomeostasis in serum and hippocampus and depression-like behavior in CRS exposure animals observed in present study could be normalized by zinc and imipramine. The combination of zinc and imipramine in low dose has synergetic effects. The possible mechanism might be correlated to GPR39 receptor-related pathway. PMID:26985741

  5. A friction regulation hybrid driving method for backward motion restraint of the smooth impact drive mechanism

    Science.gov (United States)

    Wang, Liang; Chen, Dong; Cheng, Tinghai; He, Pu; Lu, Xiaohui; Zhao, Hongwei

    2016-08-01

    The smooth impact drive mechanism (SIDM) is a type of piezoelectric actuator that has been developed for several decades. As a kind of driving method for the SIDM, the traditional sawtooth (TS) wave is always employed. The kinetic friction force during the rapid contraction stage usually results in the generation of a backward motion. A friction regulation hybrid (FRH) driving method realized by a composite waveform for the backward motion restraint of the SIDM is proposed in this paper. The composite waveform is composed of a sawtooth driving (SD) wave and a sinusoidal friction regulation (SFR) wave which is applied to the rapid deformation stage of the SD wave. A prototype of the SIDM was fabricated and its output performance under the excitation of the FRH driving method and the TS wave driving method was tested. The results indicate that the backward motion can be restrained obviously using the FRH driving method. Compared with the driving effect of the TS wave, the backward rates of the prototype in forward and reverse motions are decreased by 83% and 85%, respectively.

  6. Chronic brief restraint decreases in vivo binding of benzodiazepine receptor ligand to mouse brain.

    Science.gov (United States)

    Mosaddeghi, M; Burke, T F; Moerschbaecher, J M

    1993-01-01

    This study examines the effects of chronic brief restraint on in vivo benzodiazepine (BZD) receptor binding in mouse brain. Three groups of mice were used. Mice in group 1 were neither restrained nor injected (ACUTE control). Mice in group 2 were restrained for 5-6 s by grabbing the back skin and holding the subject upside-down at a 45 degrees angle as if to be injected (CHRONIC SHAM control) for 7 d. Mice in group 3 (CHRONIC SALINE) received daily single intraperitoneal (ip) injections of saline (5 mL/kg) for 7 d. On d 8 BZD receptors were labeled in vivo by administration of 3 microCi [3H]flumazenil (ip). The levels of ligand bound in vivo to cerebral cortex (CX), cerebellum (CB), brain stem (BS), striatum (ST), hippocampus (HP), and hypothalamus (HY) were determined. Results indicated that the level of binding was significantly (p stress produces a decrease in BZD receptor binding sites. PMID:8385464

  7. Wheelchair tiedown and occupant restraint loading associated with adult manual transit wheelchair in rear impact

    Directory of Open Access Journals (Sweden)

    Zdravko Salipur, MEng

    2010-04-01

    Full Text Available Proper securement of wheelchairs in motor vehicles is vital to providing wheelchair users an adequate level of safety in a crash. Thus far, wheelchair tiedown and occupant restraint systems (WTORS loading has mostly been examined under frontal impact conditions. Because of the inherent crash dynamic differences, rear-impact loading of WTORS is expected to differ greatly. In this study, three identical, reinforced, manual, folding, X-braced ANSI/RESNA WC19 wheelchairs were subjected to an International Organization for Standardization-proposed rear-impact crash pulse. WTORS loads (front tiedowns, rear tiedowns, lap belt, and shoulder belt were measured and compared with frontal impact WTORS loading. Rear impact produced substantially higher loads (up to 7,851 N in the front tiedowns than frontal impact. The rear tiedowns experienced relatively negligible loading (up to 257 N in rear impact, while rear-impact dynamics caused the lap belt (maximum load of 1,865 N to be loaded substantially more than the shoulder belt (maximum load of 68 N. Considering differences in frontal and rear impact WTORS loading is important to proper WTORS design and, thus, protection of wheelchair-seated occupants subjected to rear-impact events.

  8. Chronic restraint stress inhibits hair growth via substance P mediated by reactive oxygen species in mice.

    Directory of Open Access Journals (Sweden)

    Nan Liu

    Full Text Available BACKGROUNDS: Solid evidence has demonstrated that psychoemotional stress induced alteration of hair cycle through neuropeptide substance P (SP mediated immune response, the role of reactive oxygen species (ROS in brain-skin-axis regulation system remains unknown. OBJECTIVES: The present study aims to investigate possible mechanisms of ROS in regulation of SP-mast cell signal pathway in chronic restraint stress (CRS, a model of chronic psychoemotional stress which induced abnormal of hair cycle. METHODS AND RESULTS: Our results have demonstrated that CRS actually altered hair cycle by inhibiting hair follicle growth in vivo, prolonging the telogen stage and delaying subsequent anagen and catagen stage. Up-regulation of SP protein expression in cutaneous peripheral nerve fibers and activation of mast cell were observed accompanied with increase of lipid peroxidation levels and reduction of the activities of superoxide dismutase (SOD and glutathione peroxidase (GSH-Px in CRS mice skin. In addition, SP receptor antagonist (RP67580 reduced mast cell activations and lipid peroxidation levels as well as increased GSH-Px activity and normalized hair cycle. Furthermore, antioxidant Tempol (a free radical scavenger also restored hair cycle, reduced SP protein expression and mast cell activation. CONCLUSIONS: Our study provides the first solid evidence for how ROS play a role in regulation of psychoemotional stress induced SP-Mast cell pathway which may provide a convincing rationale for antioxidant application in clinical treatment with psychological stress induced hair loss.

  9. Power Transformer Differential Protection Based on Neural Network Principal Component Analysis, Harmonic Restraint and Park's Plots

    Directory of Open Access Journals (Sweden)

    Manoj Tripathy

    2012-01-01

    Full Text Available This paper describes a new approach for power transformer differential protection which is based on the wave-shape recognition technique. An algorithm based on neural network principal component analysis (NNPCA with back-propagation learning is proposed for digital differential protection of power transformer. The principal component analysis is used to preprocess the data from power system in order to eliminate redundant information and enhance hidden pattern of differential current to discriminate between internal faults from inrush and overexcitation conditions. This algorithm has been developed by considering optimal number of neurons in hidden layer and optimal number of neurons at output layer. The proposed algorithm makes use of ratio of voltage to frequency and amplitude of differential current for transformer operating condition detection. This paper presents a comparative study of power transformer differential protection algorithms based on harmonic restraint method, NNPCA, feed forward back propagation neural network (FFBPNN, space vector analysis of the differential signal, and their time characteristic shapes in Park’s plane. The algorithms are compared as to their speed of response, computational burden, and the capability to distinguish between a magnetizing inrush and power transformer internal fault. The mathematical basis for each algorithm is briefly described. All the algorithms are evaluated using simulation performed with PSCAD/EMTDC and MATLAB.

  10. Restraint of fatigue crack growth by wedge effects of fine particles

    CERN Document Server

    Takahashi, I; Kotani, N

    2000-01-01

    Presents some experimental results which demonstrate restraint of fatigue crack growth in an Al-Mg alloy by wedge effects of fine particles. Fatigue test specimens were machined from a JIS A5083P-O Al-Mg alloy plate of 5 mm thickness and an EDM starter notch was introduced to each specimen. Three kinds of fine particles were prepared as the materials to be wedged into the fatigue cracks, i.e. magnetic particles and two kinds of alumina particles having different mean particle sizes of 47.3 mu m and 15.2 mu m. Particles of each kind were suspended in an oil to form a paste, which was applied on the specimen surface covering the notch zone prior to the fatigue tests. In order to make some fracture mechanics approaches, in situ observations of fatigue cracks were performed for the two cases using a CCD microscope, with a magnification of *1000. The crack length and the crack opening displacement (COD) at the notch root, delta , were measured. The crack retardation effect continues almost through the entire lifet...

  11. The effect of mechanical restraint on the deformation of Zircaloy cladding

    International Nuclear Information System (INIS)

    Zircaloy cladding, deformed at temperatures postulated for loss-of-coolant accidents, can exhibit considerable ductility. The actual circumferential strain is governed by the temperature uniformity around the rod during the time at which the major part of the deformation occurs. If the bulges in neighbouring rods in a multi-rod array touch before rupture, and the array is large enough for the outer rods to restrain bulges rather than be pushed away by them, then the stress in such bulges drops. However the stress in adjacent axial regions of the cladding which have not contacted remains high and these continue to strain until they also interact, thus propagating the bulging axially. Meanwhile the non-contacted portions of the interacting bulges continue to strain slowly into the remaining sub-channels. Illustrative calculations suggest that the mechanical restraint of bulging cladding will only be effective in increasing sub-channel blockage when the failure strains are greater than 60-70%. This may occur with temperature differences between neighbouring rods of 10-250C if the deformation process is thermally stabilised. (author)

  12. The influence of eating rate on satiety and intake among participants exhibiting high dietary restraint

    Directory of Open Access Journals (Sweden)

    Gregory J. Privitera

    2012-01-01

    Full Text Available Studies show inconsistent results with regards to whether eating slower can enhance satiety and reduce intake in a meal. Some methodological differences are apparent and could potentially explain why results are not consistent across studies.To determine whether eating slower can enhance satiety and reduce intake when rate of eating is manipulated and not manipulated in a kitchen setting using a sample of participants who exhibit high dietary restraint (HDR.Two samples of college students who exhibit HDR, which is a group likely to use behavioral strategies to manage intake, were selected in a prescreening session. Participants were told how fast or slow to eat (Variation 1 or allowed to eat at their own pace (Variation 2. Self-reported satiety during the meal and amount consumed was recorded. The types of foods, macronutrient intakes, weights of foods, order of food intakes, and the dimensions of foods were held constant between groups to control for group differences in the sensory and hedonic qualities of the meals.Eating slower enhanced mid-meal satiety ratings, but only when instructions were given to eat fast or slow (Variation 1. In both variations, eating slower did not reduce amount consumed in the meal, although each variation had sufficient power to detect differences.Eating slower is not likely to be an effective strategy to control intake in a meal among those exhibiting HDR.

  13. Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation.

    Science.gov (United States)

    Wang, Meina; Hill, Matthew N; Zhang, Longhua; Gorzalka, Boris B; Hillard, Cecilia J; Alger, Bradley E

    2012-01-01

    Exposure to behavioural stress normally triggers a complex, multilevel response of the hypothalamic-pituitary-adrenal (HPA) axis that helps maintain homeostatic balance. Although the endocannabinoid (eCB) system (ECS) is sensitive to chronic stress, few studies have directly addressed its response to acute stress. Here we show that acute restraint stress enhances eCB-dependent modulation of GABA release measured by whole-cell voltage clamp of inhibitory postsynaptic currents (IPSCs) in rat hippocampal CA1 pyramidal cells in vitro. Both Ca(2+)-dependent, eCB-mediated depolarization-induced suppression of inhibition (DSI), and muscarinic cholinergic receptor (mAChR)-mediated eCB mobilization are enhanced following acute stress exposure. DSI enhancement is dependent on the activation of glucocorticoid receptors (GRs) and is mimicked by both in vivo and in vitro corticosterone treatment. This effect does not appear to involve cyclooxygenase-2 (COX-2), an enzyme that can degrade eCBs; however, treatment of hippocampal slices with the L-type calcium (Ca(2+)) channel inhibitor, nifedipine, reverses while an agonist of these channels mimics the effect of in vivo stress. Finally, we find that acute stress produces a delayed (by 30 min) increase in the hippocampal content of 2-arachidonoylglycerol, the eCB responsible for DSI. These results support the hypothesis that the ECS is a biochemical effector of glucocorticoids in the brain, linking stress with changes in synaptic strength. PMID:21890595

  14. Dual capacity reciprocating compressor

    Science.gov (United States)

    Wolfe, Robert W.

    1984-01-01

    A multi-cylinder compressor 10 particularly useful in connection with northern climate heat pumps and in which different capacities are available in accordance with reversing motor 16 rotation is provided with an eccentric cam 38 on a crank pin 34 under a fraction of the connecting rods, and arranged for rotation upon the crank pin between opposite positions 180.degree. apart so that with cam rotation on the crank pin such that the crank throw is at its normal maximum value all pistons pump at full capacity, and with rotation of the crank shaft in the opposite direction the cam moves to a circumferential position on the crank pin such that the overall crank throw is zero. Pistons 24 whose connecting rods 30 ride on a crank pin 36 without a cam pump their normal rate with either crank rotational direction. Thus a small clearance volume is provided for any piston that moves when in either capacity mode of operation.

  15. Geothermal Plant Capacity Factors

    Energy Technology Data Exchange (ETDEWEB)

    Greg Mines; Jay Nathwani; Christopher Richard; Hillary Hanson; Rachel Wood

    2015-01-01

    The capacity factors recently provided by the Energy Information Administration (EIA) indicated this plant performance metric had declined for geothermal power plants since 2008. Though capacity factor is a term commonly used by geothermal stakeholders to express the ability of a plant to produce power, it is a term frequently misunderstood and in some instances incorrectly used. In this paper we discuss how this capacity factor is defined and utilized by the EIA, including discussion on the information that the EIA requests from operations in their 923 and 860 forms that are submitted both monthly and annually by geothermal operators. A discussion is also provided regarding the entities utilizing the information in the EIA reports, and how those entities can misinterpret the data being supplied by the operators. The intent of the paper is to inform the facility operators as the importance of the accuracy of the data that they provide, and the implications of not providing the correct information.

  16. Anti-stress effects of carnosine on restraint-evoked immunocompromise in mice through spleen lymphocyte number maintenance.

    Directory of Open Access Journals (Sweden)

    Yi-Fang Li

    Full Text Available Carnosine (β-alanyl-L-histidine, a naturally occurring dipeptide, has been characterized as a putative neurotransmitter and serves as a reservoir for brain histamine, which could act on histaminergic neurons system to relieve stress-induced damages. However, understanding of the role of carnosine in stress-evoked immunocompromise is limited. In this study, results showed that when mice were subjected to restraint stress, spleen index and the number of spleen lymphocytes including Natural Killer (NK cells were obviously decreased. Results also demonstrated that restraint stress decreased the cytotoxic activity of NK cells per spleen (LU(10/spleen while the activity of a single NK cell (LU(10/10(6 cells was not changed. However, oral administration of carnosine (150 and 300 mg/kg increased spleen index and number of spleen lymphocytes (including NK cells, and elevated the cytotoxic activity of NK cells per spleen in restraint-stressed mice. These results indicated that carnosine ameliorated stress-evoked immunocompromise through spleen lymphocyte number maintenance. Carnosine was further found to reduce stress-induced elevation of plasma corticosterone level. On the other hand, results showed that carnosine and RU486 (a glucocorticoids receptor antagonist treatment prevented the reduction in mitochondrion membrane potential and the release of mitochondrial cytochrome c into cytoplasm, increased Bcl-2/Bax mRNA ratio, as well as decreased terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL-positive cells in spleen lymphocytes of stressed mice. The results above suggested that the maintenance of spleen lymphocyte number by carnosine was related with the inhibition of lymphocytes apoptosis caused by glucocorticoids overflow. The stimulation of lymphocyte proliferation by carnosine also contributed to the maintenance of spleen lymphocyte number in stressed mice. In view of the elevated histamine level, the anti

  17. Markets and Institutional Capacity

    DEFF Research Database (Denmark)

    Ingemann, Jan Holm

    2010-01-01

    Adequate explanations concerning the introduction of production and consumption of organic food in Denmark imply the necessity to engage a certain understanding of markets. Markets should subsequently not be seen as entities nor places but as complex relations between human actors. Further......, the establishment, maintenance and development of markets are depending on the capacity of the actors to enter into continuous and enhancing interplay....

  18. Flood Bypass Capacity Optimization

    Science.gov (United States)

    Siclari, A.; Hui, R.; Lund, J. R.

    2015-12-01

    Large river flows can damage adjacent flood-prone areas, by exceeding river channel and levee capacities. Particularly large floods are difficult to contain in leveed river banks alone. Flood bypasses often can efficiently reduce flood risks, where excess river flow is diverted over a weir to bypasses, that incur much less damage and cost. Additional benefits of bypasses include ecosystem protection, agriculture, groundwater recharge and recreation. Constructing or expanding an existing bypass costs in land purchase easements, and levee setbacks. Accounting for such benefits and costs, this study develops a simple mathematical model for optimizing flood bypass capacity using benefit-cost and risk analysis. Application to the Yolo Bypass, an existing bypass along the Sacramento River in California, estimates optimal capacity that economically reduces flood damage and increases various benefits, especially for agriculture. Land availability is likely to limit bypass expansion. Compensation for landowners could relax such limitations. Other economic values could affect the optimal results, which are shown by sensitivity analysis on major parameters. By including land geography into the model, location of promising capacity expansions can be identified.

  19. Discontinuous symplectic capacities

    OpenAIRE

    Zehmisch, Kai; Ziltener, Fabian

    2012-01-01

    Comment: We include generalizations to higher dimensions due to the unknown referee and Janko Latschev. We add examples of open sets with connected boundary on which the shell capacity is not continuous. 3rd and 4th version: minor changes, to appear in J. Fixed Point Theory Appl

  20. Vedr.: Military capacity building

    DEFF Research Database (Denmark)

    Larsen, Josefine Kühnel; Struwe, Lars Bangert

    2013-01-01

    Kühnel Larsen and researcher Lars Bangert Struwe of CMS had organized a seminar in collaboration with Royal Danish Defense Colleg and the East African Security Governance Network. The seminar focused on some of the risks involved in Military capacity building and how these risks are dealt with from...

  1. BioMagResBank databases DOCR and FRED containing converted and filtered sets of experimental NMR restraints and coordinates from over 500 protein PDB structures

    International Nuclear Information System (INIS)

    We present two new databases of NMR-derived distance and dihedral angle restraints: the Database Of Converted Restraints (DOCR) and the Filtered Restraints Database (FRED). These databases currently correspond to 545 proteins with NMR structures deposited in the Protein Databank (PDB). The criteria for inclusion were that these should be unique, monomeric proteins with author-provided experimental NMR data and coordinates available from the PDB capable of being parsed and prepared in a consistent manner. The Wattos program was used to parse the files, and the CcpNmr FormatConverter program was used to prepare them semi-automatically. New modules, including a new implementation of Aqua in the BioMagResBank (BMRB) software Wattos were used to analyze the sets of distance restraints (DRs) for inconsistencies, redundancies, NOE completeness, classification and violations with respect to the original coordinates. Restraints that could not be associated with a known nomenclature were flagged. The coordinates of hydrogen atoms were recalculated from the positions of heavy atoms to allow for a full restraint analysis. The DOCR database contains restraint and coordinate data that is made consistent with each other and with IUPAC conventions. The FRED database is based on the DOCR data but is filtered for use by test calculation protocols and longitudinal analyses and validations. These two databases are available from websites of the BMRB and the Macromolecular Structure Database (MSD) in various formats: NMR-STAR, CCPN XML, and in formats suitable for direct use in the software packages CNS and CYANA

  2. SASSIE: A program to study intrinsically disordered biological molecules and macromolecular ensembles using experimental scattering restraints

    Science.gov (United States)

    Curtis, Joseph E.; Raghunandan, Sindhu; Nanda, Hirsh; Krueger, Susan

    2012-02-01

    A program to construct ensembles of biomolecular structures that are consistent with experimental scattering data are described. Specifically, we generate an ensemble of biomolecular structures by varying sets of backbone dihedral angles that are then filtered using experimentally determined restraints to rapidly determine structures that have scattering profiles that are consistent with scattering data. We discuss an application of these tools to predict a set of structures for the HIV-1 Gag protein, an intrinsically disordered protein, that are consistent with small-angle neutron scattering experimental data. We have assembled these algorithms into a program called SASSIE for structure generation, visualization, and analysis of intrinsically disordered proteins and other macromolecular ensembles using neutron and X-ray scattering restraints. Program summaryProgram title: SASSIE Catalogue identifier: AEKL_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKL_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License v3 No. of lines in distributed program, including test data, etc.: 3 991 624 No. of bytes in distributed program, including test data, etc.: 826 Distribution format: tar.gz Programming language: Python, C/C++, Fortran Computer: PC/Mac Operating system: 32- and 64-bit Linux (Ubuntu 10.04, Centos 5.6) and Mac OS X (10.6.6) RAM: 1 GB Classification: 3 External routines: Python 2.6.5, numpy 1.4.0, swig 1.3.40, scipy 0.8.0, Gnuplot-py-1.8, Tcl 8.5, Tk 8.5, Mac installation requires aquaterm 1.0 (or X window system) and Xcode 3 development tools. Nature of problem: Open source software to generate structures of disordered biological molecules that subsequently allow for the comparison of computational and experimental results is limiting the use of scattering resources. Solution method: Starting with an all atom model of a protein, for example, users can input

  3. Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats.

    Directory of Open Access Journals (Sweden)

    Anna Rita Zuena

    Full Text Available Prenatal Restraint Stress (PRS in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issue. Our group has uncovered a pronounced gender difference in the effects of PRS (stress delivered to the mothers 3 times per day during the last 10 days of pregnancy on anxiety, spatial learning, and a series of neurobiological parameters classically associated with hippocampus-dependent behaviors. Adult male rats subjected to PRS ("PRS rats" showed increased anxiety-like behavior in the elevated plus maze (EPM, a reduction in the survival of newborn cells in the dentate gyrus, a reduction in the activity of mGlu1/5 metabotropic glutamate receptors in the ventral hippocampus, and an increase in the levels of brain-derived neurotrophic factor (BDNF and pro-BDNF in the hippocampus. In contrast, female PRS rats displayed reduced anxiety in the EPM, improved learning in the Morris water maze, an increase in the activity of mGlu1/5 receptors in the ventral and dorsal hippocampus, and no changes in hippocampal neurogenesis or BDNF levels. The direction of the changes in neurogenesis, BDNF levels and mGlu receptor function in PRS animals was not consistent with the behavioral changes, suggesting that PRS perturbs the interdependency of these particular parameters and their relation to hippocampus-dependent behavior. Our data suggest that the epigenetic changes in hippocampal neuroplasticity induced by early environmental challenges are critically sex-dependent and that the behavioral outcome may diverge in males and females.

  4. Nociception- and anxiety-like behavior in rats submitted to different periods of restraint stress.

    Science.gov (United States)

    Gameiro, Gustavo Hauber; Gameiro, Paula Hauber; Andrade, Annicele da Silva; Pereira, Lígia Ferrinho; Arthuri, Mariana Trevisani; Marcondes, Fernanda Klein; Veiga, Maria Cecília Ferraz de Arruda

    2006-04-15

    The aim of this study was to evaluate the effect of acute, sub-chronic and chronic stress on nociception induced by formalin injection in rats' temporomandibular joint (TMJ). It was evaluated the relation between blood levels of adrenocorticotropin, corticosterone, the levels of anxiety and nociceptive responses recorded after different stress protocols. Animals were initially submitted to acute restraint stress (15; 30 min and 1 h), or exposed to sub-chronic (3 days-1 h/day) or chronic stress (40 days-1 h/day). Then, animals were (1) killed immediately to collect blood for hormonal determinations; or (2) submitted to the elevated plus-maze to evaluate anxiety; or (3) submitted to the TMJ formalin test to evaluate nociception. It was also evaluated the role of serotoninergic and opioid systems in nociceptive changes induced by stress. For this, the serotonin-selective reuptake inhibitor (fluoxetine 10 mg/kg) and the opioid agonist (morphine 1-5 mg/kg) were administered before the nociception test. All stress protocols significantly raised the levels of ACTH or corticosterone, as well as the anxiety behavior. In relation to nociception, the chronic stressed animals showed an increase in nociceptive responses (hyperalgesia). In this group, there was a reduction in the morphine analgesic effects, suggesting dysfunction in the endogenous opioid system. Fluoxetine had an analgesic effect in both stressed and control groups, although this effect was more evident in the stressed group. It was concluded that stress-induced hyperalgesia may result from changes in the serotoninergic and opioid systems, which can explain, at least in part, the important link between stress and orofacial pain. PMID:16488452

  5. Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints.

    Directory of Open Access Journals (Sweden)

    Jayant James Jayasundar

    Full Text Available Cardiac troponin (cTn is the Ca(2+-sensitive molecular switch that controls cardiac muscle activation and relaxation. However, the molecular detail of the switching mechanism and how the Ca(2+ signal received at cardiac troponin C (cTnC is communicated to cardiac troponin I (cTnI are still elusive. To unravel the structural details of troponin switching, we performed ensemble Förster resonance energy transfer (FRET measurements and molecular dynamic (MD simulations of the cardiac troponin core domain complex. The distance distributions of forty five inter-residue pairs were obtained under Ca(2+-free and saturating Ca(2+ conditions from time-resolved FRET measurements. These distances were incorporated as restraints during the MD simulations of the cardiac troponin core domain. Compared to the Ca(2+-saturated structure, the absence of regulatory Ca(2+ perturbed the cTnC N-domain hydrophobic pocket which assumed a closed conformation. This event partially unfolded the cTnI regulatory region/switch. The absence of Ca(2+, induced flexibility to the D/E linker and the cTnI inhibitory region, and rotated the cTnC N-domain with respect to rest of the troponin core domain. In the presence of saturating Ca(2+ the above said phenomenon were absent. We postulate that the secondary structure perturbations experienced by the cTnI regulatory region held within the cTnC N-domain hydrophobic pocket, coupled with the rotation of the cTnC N-domain would control the cTnI mobile domain interaction with actin. Concomitantly the rotation of the cTnC N-domain and perturbation of the D/E linker rigidity would control the cTnI inhibitory region interaction with actin to effect muscle relaxation.

  6. Functional genomics of the muscle response to restraint and transport in chickens.

    Science.gov (United States)

    Hazard, D; Fernandez, X; Pinguet, J; Chambon, C; Letisse, F; Portais, J-C; Wadih-Moussa, Z; Rémignon, H; Molette, C

    2011-09-01

    In the present study, we used global approaches (proteomics, transcriptomics, and metabolomics) to assess the molecular basis of the muscle response to stress in chickens. A restraint test, combined with transport for 2 h (RT test) was chosen as the potentially stressful situation. Chickens (6 wk old) were either nontreated (control chickens) or submitted to the RT test (treated chickens). The RT test induced a 6-fold increase in corticosterone concentrations, suggesting hypothalamic-pituitary-adrenal axis activation. The RT test decreased the relative abundance of several hexose phosphates [glucose-1-P (G1P), glucose-6-P (G6P), fructose-6-P (F6P), and mannose-6-P (M6P)] in thigh muscle. In addition, 55 transcripts, among which 39 corresponded to unique annotated genes, were significantly up- (12 genes) or downregulated (27 genes) by treatment. Similarly, 45 proteic spots, among which 29 corresponded to unique annotated proteins, were overexpressed (11 proteins), underexpressed (14 proteins), or only expressed in treated chickens. Integrative analysis of differentially expressed genes and proteins showed that most transcripts and proteins belong to 2 networks whose genes were mainly related with cytoskeleton structure or carbohydrate metabolism. Whereas the decrease in energetic metabolites suggested an activation of glycogenolysis and glycolysis in response to the RT test, the reduced expression of genes and proteins involved in these pathways suggested the opposite. We hypothesized that the prolonged RT test resulted in a repression of glycogenolysis and glycolysis in thigh muscle of chickens. The down-expression of genes and proteins involved in the formation of fiber stress after the RT test suggests a reinforcement of myofibrils in response to stress. PMID:21512117

  7. Absorptive Capacity and Diversity

    DEFF Research Database (Denmark)

    Kristinsson, Kári

    that contribute to the neo-Schumpeterian economics literature and hopefully inspires further research into this area. The main findings of the dissertation can be divided into four distinct parts. First, diversity of individuals within firms is associated with firm innovative performance. This is in line......One of the most influential contributions to neo-Schumpeterian economics is Cohen and Levinthal‘s papers on absorptive capacity. Since their publication in the late 1980s and early 1990s the concept absorptive capacity has had substantial impact on research in economics and management, including...... international business, organizational economics, strategic management, technology management and last but not least neo-Schumpeterian economics. The goal of this dissertation is to examine what many consider as neglected arguments from the work by Cohen and Levinthal and thereby illuminate an otherwise...

  8. Value for railway capacity

    DEFF Research Database (Denmark)

    Sameni, Melody Khadem; Preston, John M.

    2012-01-01

    Growth in rail traffic has not been matched by increases in railway infrastructure. Given this capacity challenge and the current restrictions on public spending, the allocation and the utilization of existing railway capacity are more important than ever. Great Britain has had the greatest growth...... DEA work on the economic efficiency of railways by considering a new combination of input-output that also incorporates quality of service. The constant and variable returns to scale models are applied to the case study of franchised passenger operators in Great Britain. The follow-up Tobit regression...... model shows positive correlation between serving London and the efficiency scores. There is negative correlation between offering regional services (average length of journeys less than 40 mi) and the efficiency scores. The overall study and the results can provide helpful insights for railway...

  9. Deficiency of employability capacity

    OpenAIRE

    Pelse I.; Vilka L.

    2012-01-01

    Young unemployed people have comprised one of the significantly largest groups of the unemployed people in Latvia in recent years. One of the reasons why young people have difficulty integrating into the labour market is the “expectation gap” that exists in the relations between employers and the new generation of workers. Employers focus on capacity-building for employability such individual factors as strength, patience, self-discipline, self-reliance, self-motivation, etc., which having a ...

  10. Heat Capacity Mapping Mission

    Science.gov (United States)

    Nilsson, C. S.; Andrews, J. C.; Scully-Power, P.; Ball, S.; Speechley, G.; Latham, A. R. (Principal Investigator)

    1980-01-01

    The Tasman Front was delineated by airborne expendable bathythermograph survey; and an Heat Capacity Mapping Mission (HCMM) IR image on the same day shows the same principal features as determined from ground-truth. It is clear that digital enhancement of HCMM images is necessary to map ocean surface temperatures and when done, the Tasman Front and other oceanographic features can be mapped by this method, even through considerable scattered cloud cover.

  11. Functional Capacity Evaluation & Disability

    OpenAIRE

    Chen, Joseph J.

    2007-01-01

    Function, Impairment, and Disability are words in which many physicians have little interest. Most physicians are trained to deal with structure and physiology and not function and disability. The purpose of this article is to address some of the common questions that many physicians have with the use of functional capacity evaluation and disability and also to provide a unifying model that can explain the medical and societal variables in predicting disability. We will first define the funct...

  12. Capacity Utilization and Market Power

    OpenAIRE

    Fagnart, J.F.; Licandro, O.; Sneessens, Henri

    1997-01-01

    In a monopolistic competition framework, we propose a dynamic model in which capacity underutilization is a macroeconomic equilibrium feature relying on a diversity of microeconomic situations. Capacity underutilization follows from microeconomic uncertainty at the time firms must decide on their productive capacity. We settle a relationship between capacity utilization and markups via the effect of capacity utilization rate changes on firms' market power. We show that such a relationship inf...

  13. Competence building capacity shortage

    International Nuclear Information System (INIS)

    The objective of the project 'Competence Building Capacity Shortage' has been 'to increase knowledge about central approaches aimed at solving the peaking capacity problem in restructured power systems'. With respect to reserve markets, a model was developed in the project to analyze the relations between reserve requirements and prices in the spot and reserve markets respectively. A mathematical model was also developed and implemented, which also includes the balance market, and has a good ability to predict the relations between these markets under various assumptions. With some further development, this model can be used fore realistic analyses of these markets in a Nordic context. It was also concluded that certain system requirements with respect to frequency and time deviation can be relaxed without adverse effects. However, the requirements to system bias, Frequency Activated Operating Reserves and Frequency Activated Contingency Reserves cannot be relaxed, the latter because they must cover the dimensioning fault in the system. On the other hand, Fast Contingency Reserves can be reduced by removing requirements to national balances. Costs can furthermore be reduced by increasingly adapting a Nordic as opposed to national approach. A model for stepwise power flow was developed in the project, which is especially useful to analyze slow power system dynamics. This is relevant when analysing the effects of reserve requirements. A model for the analysis of the capacity balance in Norway and Sweden was also developed. This model is useful for looking at the future balance under various assumptions regarding e.g. weather conditions, demand growth and the development of the generation system. With respect to the present situation, if there is some price flexibility on the demand side and system operators are able to use reserves from the demand side, the probability for load shedding during the peak load hour is close to zero under the weather conditions after

  14. Competence building capacity shortage

    Energy Technology Data Exchange (ETDEWEB)

    Doorman, Gerard; Wangensteen, Ivar; Bakken, Bjoern

    2005-02-01

    The objective of the project 'Competence Building Capacity Shortage' has been 'to increase knowledge about central approaches aimed at solving the peaking capacity problem in restructured power systems'. With respect to reserve markets, a model was developed in the project to analyze the relations between reserve requirements and prices in the spot and reserve markets respectively. A mathematical model was also developed and implemented, which also includes the balance market, and has a good ability to predict the relations between these markets under various assumptions. With some further development, this model can be used fore realistic analyses of these markets in a Nordic context. It was also concluded that certain system requirements with respect to frequency and time deviation can be relaxed without adverse effects. However, the requirements to system bias, Frequency Activated Operating Reserves and Frequency Activated Contingency Reserves cannot be relaxed, the latter because they must cover the dimensioning fault in the system. On the other hand, Fast Contingency Reserves can be reduced by removing requirements to national balances. Costs can furthermore be reduced by increasingly adapting a Nordic as opposed to national approach. A model for stepwise power flow was developed in the project, which is especially useful to analyze slow power system dynamics. This is relevant when analysing the effects of reserve requirements. A model for the analysis of the capacity balance in Norway and Sweden was also developed. This model is useful for looking at the future balance under various assumptions regarding e.g. weather conditions, demand growth and the development of the generation system. With respect to the present situation, if there is some price flexibility on the demand side and system operators are able to use reserves from the demand side, the probability for load shedding during the peak load hour is close to zero under the weather

  15. Effect of restraint stress on depression-like behaviors in rats after transient focal cerebral ischemic injury

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: Restraint stress is a typical psychophysiological stressor. Simulating the early passion and difficulty in walking of patients after attack of stroke meets onset features.OBJECTIVE: To evaluate the effect of restraint stress on depression-like behaviors in rats after transient focal cerebral ischemic injury, and to investigate the feasibility for its being as modeling method of depression model after stroke.DESIGN: A randomized controlled animal experiment.SETTING: Department of Clinical Medicine, Faculty of Aerospace Medicine of the Fourth Military Medical University of Chinese PLA.MATERIALS: Forty-eight male Sprague-Dawley rats, weighing 240 - 270 g, provided by the Experimental Animal Center of the Fourth Military Medical University of Chinese PLA were used in the current study.METHODS: The experiments were carried out in the Faculty of Aerospace Medicine of the Fourth Military Medical University of Chinese PLA between August 2005 and August 2006. ①Experiment intervention: The rats were randomized into middle cerebral artery occlusion-reperfusion (MCAO) +stress group, simple MCAO group, sham-operation + stress group and simple sham-operation group, with 12 rats in each group.Rats in the first two groups were developed into cerebral ischemia/reperfusion models by suture-occluded method. Rats in the MCAO+stress group were modeled and restraint stress scheme was performed. At week 5 after modeling, the rats were placed in self-made restraining tubes, 2 hours/time, once a day, for 2 successive weeks. The common carotid artery, external and internal carotid arteries of rats in the latter two groups were exposed. The stress way of sham-operation+ stress group was the same as that of MCAO+ stress group. ②The neurological status grading and motor performance evaluation (screen test, rota-rod test and balance beam test) were conducted in rats with simple sham-operation group and MCAO group before, 1st and 28th days after modeling. Depression-like behavior

  16. Evaluation of an evidence-based guidance on the reduction of physical restraints in nursing homes: a cluster-randomised controlled trial [ISRCTN34974819

    Directory of Open Access Journals (Sweden)

    Haastert Burkhard

    2009-09-01

    Full Text Available Abstract Background Physical restraints are regularly applied in German nursing homes. Their frequency varies substantially between centres. Beneficial effects of physical restraints have not been proven, however, observational studies and case reports suggest various adverse effects. We developed an evidence-based guidance on this topic. The present study evaluates the clinical efficacy and safety of an intervention programme based on this guidance aimed to reduce physical restraints and minimise centre variations. Methods/Design Cluster-randomised controlled trial with nursing homes randomised either to the intervention group or to the control group with standard information. The intervention comprises a structured information programme for nursing staff, information materials for legal guardians and residents' relatives and a one-day training workshop for nominated nurses. A total of 36 nursing home clusters including approximately 3000 residents will be recruited. Each cluster has to fulfil the inclusion criteria of at least 20% prevalence of physical restraints at baseline. The primary endpoint is the number of residents with at least one physical restraint at six months. Secondary outcome measures are the number of falls and fall-related fractures. Discussion If successful, the intervention should be implemented throughout Germany. In case the intervention does not succeed, a three-month pre-post-study with an optimised intervention programme within the control group will follow the randomised trial. Trial registration ISRCTN34974819

  17. Evaluation of an evidence-based guidance on the reduction of physical restraints in nursing homes: a cluster-randomised controlled trial [ISRCTN34974819

    Science.gov (United States)

    Haut, Antonie; Köpke, Sascha; Gerlach, Anja; Mühlhauser, Ingrid; Haastert, Burkhard; Meyer, Gabriele

    2009-01-01

    Background Physical restraints are regularly applied in German nursing homes. Their frequency varies substantially between centres. Beneficial effects of physical restraints have not been proven, however, observational studies and case reports suggest various adverse effects. We developed an evidence-based guidance on this topic. The present study evaluates the clinical efficacy and safety of an intervention programme based on this guidance aimed to reduce physical restraints and minimise centre variations. Methods/Design Cluster-randomised controlled trial with nursing homes randomised either to the intervention group or to the control group with standard information. The intervention comprises a structured information programme for nursing staff, information materials for legal guardians and residents' relatives and a one-day training workshop for nominated nurses. A total of 36 nursing home clusters including approximately 3000 residents will be recruited. Each cluster has to fulfil the inclusion criteria of at least 20% prevalence of physical restraints at baseline. The primary endpoint is the number of residents with at least one physical restraint at six months. Secondary outcome measures are the number of falls and fall-related fractures. Discussion If successful, the intervention should be implemented throughout Germany. In case the intervention does not succeed, a three-month pre-post-study with an optimised intervention programme within the control group will follow the randomised trial. Trial registration ISRCTN34974819 PMID:19735564

  18. Structure determination of uniformly 13C, 15N labeled protein using qualitative distance restraints from MAS solid-state 13C-NMR observed paramagnetic relaxation enhancement

    International Nuclear Information System (INIS)

    Magic angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) is a powerful method for structure determination of insoluble biomolecules. However, structure determination by MAS solid-state NMR remains challenging because it is difficult to obtain a sufficient amount of distance restraints owing to spectral complexity. Collection of distance restraints from paramagnetic relaxation enhancement (PRE) is a promising approach to alleviate this barrier. However, the precision of distance restraints provided by PRE is limited in solid-state NMR because of incomplete averaged interactions and intermolecular PREs. In this report, the backbone structure of the B1 domain of streptococcal protein G (GB1) has been successfully determined by combining the CS-Rosetta protocol and qualitative PRE restraints. The derived structure has a Cα RMSD of 1.49 Å relative to the X-ray structure. It is noteworthy that our protocol can determine the correct structure from only three cysteine-EDTA-Mn2+ mutants because this number of PRE sites is insufficient when using a conventional structure calculation method based on restrained molecular dynamics and simulated annealing. This study shows that qualitative PRE restraints can be employed effectively for protein structure determination from a limited conformational sampling space using a protein fragment library

  19. Effect of acute and repeated restraint stress on glucose oxidation to CO2 in hippocampal and cerebral cortex slices

    Directory of Open Access Journals (Sweden)

    Torres I.L.S.

    2001-01-01

    Full Text Available It has been suggested that glucocorticoids released during stress might impair neuronal function by decreasing glucose uptake by hippocampal neurons. Previous work has demonstrated that glucose uptake is reduced in hippocampal and cerebral cortex slices 24 h after exposure to acute stress, while no effect was observed after repeated stress. Here, we report the effect of acute and repeated restraint stress on glucose oxidation to CO2 in hippocampal and cerebral cortex slices and on plasma glucose and corticosterone levels. Male adult Wistar rats were exposed to restraint 1 h/day for 50 days in the chronic model. In the acute model there was a single exposure. Immediately or 24 h after stress, the animals were sacrificed and the hippocampus and cerebral cortex were dissected, sliced, and incubated with Krebs buffer, pH 7.4, containing 5 mM glucose and 0.2 µCi D-[U-14C] glucose. CO2 production from glucose was estimated. Trunk blood was also collected, and both corticosterone and glucose were measured. The results showed that corticosterone levels after exposure to acute restraint were increased, but the increase was smaller when the animals were submitted to repeated stress. Blood glucose levels increased after both acute and repeated stress. However, glucose utilization, measured as CO2 production in hippocampal and cerebral cortex slices, was the same in stressed and control groups under conditions of both acute and chronic stress. We conclude that, although stress may induce a decrease in glucose uptake, this effect is not sufficient to affect the energy metabolism of these cells.

  20. Refined solution structure of the 82-kDa enzyme malate synthase G from joint NMR and synchrotron SAXS restraints

    International Nuclear Information System (INIS)

    Determination of the accurate three-dimensional structure of large proteins by NMR remains challenging due to a loss in the density of experimental restraints resulting from the often prerequisite perdeuteration. Solution small-angle scattering, which carries long-range translational information, presents an opportunity to enhance the structural accuracy of derived models when used in combination with global orientational NMR restraints such as residual dipolar couplings (RDCs) and residual chemical shift anisotropies (RCSAs). We have quantified the improvements in accuracy that can be obtained using this strategy for the 82 kDa enzyme Malate Synthase G (MSG), currently the largest single chain protein solved by solution NMR. Joint refinement against NMR and scattering data leads to an improvement in structural accuracy as evidenced by a decrease from ∼4.5 to ∼3.3 A of the backbone rmsd between the derived model and the high-resolution X-ray structure, PDB code 1D8C. This improvement results primarily from medium-angle scattering data, which encode the overall molecular shape, rather than the lowest angle data that principally determine the radius of gyration and the maximum particle dimension. The effect of the higher angle data, which are dominated by internal density fluctuations, while beneficial, is also found to be relatively small. Our results demonstrate that joint NMR/SAXS refinement can yield significantly improved accuracy in solution structure determination and will be especially well suited for the study of systems with limited NMR restraints such as large proteins, oligonucleotides, or their complexes

  1. Applying the False Claims Act to Chemical and Physical Restraint Cases: Is the Government Going Too Far?

    Directory of Open Access Journals (Sweden)

    Amie E. Schaadt

    2007-04-01

    Full Text Available On August 6, 2002, Jeanne W. Price, a 79-year-old Alzheimer’s patient at the Central Montgomery Medical Center (CMMC, died while in a restraining device called a Posey vest. The CMMC staff used the restraint to keep Ms. Price from wandering the halls of the medical center by confining her in bed.1 When the patient later attempted to get out of bed, she slipped off the side, causing the vest to tighten around her chest. She soon died of asphyxiation. An attorney for the family stated that the patient may have been left unattended for up to an hour.

  2. Enhancing buckling capacity of a rectangular plate under uniaxial compression by utilizing an auxetic material

    Institute of Scientific and Technical Information of China (English)

    Zhang Yongcun; Li Xiaobin; Liu Shutian

    2016-01-01

    Auxetic materials have previously been shown to enhance various performances due to its unusual property of becoming fatter when uniaxially stretched and thinner when uniaxially com-pressed (i.e., the materials exhibit a negative Poisson’s ratio). The current study focuses on assessing the potential of an auxetic material to enhance the buckling capacity of a rectangular plate under uniaxial compression. The in-plane translational restraint along the unloaded edges that was often neglected in open literature is taken into consideration in our buckling model proposed in this study. The closed-form expressions for the critical buckling coefficient of the rectangle are provided and the predicted results agree well with those determined by the finite element method. Further-more, the results indicate that the buckling performance of a rectangular plate under uniaxial com-pression can be significantly improved by replacing the traditional material that has a positive Poisson’s ratio with an auxetic material when there is in-plane translation restraint along the unloaded edges.

  3. Surface retention capacity calculation

    Science.gov (United States)

    David, Vaclav; Dostal, Tomas

    2010-05-01

    Flood wave transformation in the floodplain is the phenomenon which is researched within interdisciplinary project NIVA - Water Retention in Floodplains and Possibilities of Retention Capacity Increase. The project focuses on broad range of floodplain ecosystem services and mitigation of flooding is one of them. Despite main influence on flood wave transformation is due to flow retardation, retention in surface depressions within floodplain has been analyzed to get better overview of whole transformation process. Detail digital relief model (DRM) has been used for given purposes to be able to analyze terrain depressions volumes. The model was developed with use of stereophotogrammetric evaluation of airborne images with high resolution of 10 cm. It was essential for purposes of presented analysis not to apply pit removal routines which are often used for generation of DRM for hydrological modelling purposes. First, the methodology of analysis was prepared and tested on artificial surface. This surface was created using random raster generation, filtration and resampling with final resolution of 1000 x 1000 units and height of maximum 10 units above datum. The methodology itself is based on analysis of areas inundated by water at different elevation levels. Volume is than calculated for each depression using extraction of terrain elevations under corresponding water level. The method was then applied on the area of Lužnice River floodplain section to assess retention capacity of real floodplain. The floodplain had to be cut into sections perpendicular to main river orientation for analyses as the method was tested for square shaped area without any significant inclination. Results obtained by mentioned analysis are presented in this paper. Acknowledgement Presented research was accomplished within national project NIVA - Water Retention in Floodplains and Possibilities of Retention Capacity Increase, nr. QH82078. The project is funded by Ministry of Agriculture of

  4. Quantum reading capacity

    Science.gov (United States)

    Pirandola, Stefano; Lupo, Cosmo; Giovannetti, Vittorio; Mancini, Stefano; Braunstein, Samuel L.

    2011-11-01

    The readout of a classical memory can be modelled as a problem of quantum channel discrimination, where a decoder retrieves information by distinguishing the different quantum channels encoded in each cell of the memory (Pirandola 2011 Phys. Rev. Lett. 106 090504). In the case of optical memories, such as CDs and DVDs, this discrimination involves lossy bosonic channels and can be remarkably boosted by the use of nonclassical light (quantum reading). Here we generalize these concepts by extending the model of memory from single-cell to multi-cell encoding. In general, information is stored in a block of cells by using a channel-codeword, i.e. a sequence of channels chosen according to a classical code. Correspondingly, the readout of data is realized by a process of ‘parallel’ channel discrimination, where the entire block of cells is probed simultaneously and decoded via an optimal collective measurement. In the limit of a large block we define the quantum reading capacity of the memory, quantifying the maximum number of readable bits per cell. This notion of capacity is nontrivial when we suitably constrain the physical resources of the decoder. For optical memories (encoding bosonic channels), such a constraint is energetic and corresponds to fixing the mean total number of photons per cell. In this case, we are able to prove a separation between the quantum reading capacity and the maximum information rate achievable by classical transmitters, i.e. arbitrary classical mixtures of coherent states. In fact, we can easily construct nonclassical transmitters that are able to outperform any classical transmitter, thus showing that the advantages of quantum reading persist in the optimal multi-cell scenario.

  5. Enhancing human capacities

    CERN Document Server

    Savulescu, Julian; Kahane, Guy

    2011-01-01

    Enhancing Human Capacities is the first to review the very latest scientific developments in human enhancement. It is unique in its examination of the ethical and policy implications of these technologies from a broad range of perspectives. Presents a rich range of perspectives on enhancement from world leading ethicists and scientists from Europe and North America The most comprehensive volume yet on the science and ethics of human enhancement Unique in providing a detailed overview of current and expected scientific advances in this area Discusses both general conceptual and ethical issues

  6. Capacity at Railway Stations

    DEFF Research Database (Denmark)

    Landex, Alex

    2011-01-01

    zone(s) the possible conflicts with other trains (also in the opposite direction) are taken into account leading to more trustworthy results. Although the UIC 406 methodology proposes that the railway network should be divided into line sections when trains turn around and when the train order...... is changed, this paper recommends that the railway lines are not always be divided. In case trains turn around on open (single track) line, the capacity consumption may be too low if a railway line is divided. The same can be the case if only few trains are overtaken at an overtaking station. For dead end...

  7. Airport Capacity Forecast : Short-term forecasting of runway capacity

    OpenAIRE

    Hesselink, Henk; Nibourg, Joyce; D'Estampes, Ludovic; Lezaud, Pascal

    2014-01-01

    International audience Airports expect major benefits from increasing predictability of the operation. This paper will investigate the use of forecast information to determine forecast airport capacity, which will allow airport stakeholders to optimize the use of their resources. The focus will be on forecasting runway capacity, at most airports the major factor for the overall airport capacity. The possibility to model forecast runway capacity, based on probabilistic inputs, will be inves...

  8. Deficiency of employability capacity

    Directory of Open Access Journals (Sweden)

    Pelse I.

    2012-10-01

    Full Text Available Young unemployed people have comprised one of the significantly largest groups of the unemployed people in Latvia in recent years. One of the reasons why young people have difficulty integrating into the labour market is the “expectation gap” that exists in the relations between employers and the new generation of workers. Employers focus on capacity-building for employability such individual factors as strength, patience, self-discipline, self-reliance, self-motivation, etc., which having a nature of habit and are developed in a long-term work socialization process, which begins even before the formal education and will continue throughout the life cycle. However, when the socialization is lost, these habits are depreciated faster than they can be restored. Currently a new generation is entering the labour market, which is missing the succession of work socialization. Factors, such as rising unemployment and poverty in the background over the past twenty years in Latvia have created a very unfavourable employability background of “personal circumstances” and “external factors”, which seriously have impaired formation of the skills and attitudes in a real work environment. The study reveals another paradox – the paradox of poverty. Common sense would want to argue that poverty can be overcome by the job. However, the real state of affairs shows that unfavourable coincidence of the individual, personal circumstances and external factors leads to deficit of employability capacity and possibility of marked social and employment deprivation.

  9. Workshop on moisture buffer capacity

    DEFF Research Database (Denmark)

    2003-01-01

    Summary report of a Nordtest workshop on moisture buffer capacity held at Copenhagen August 21-22 2003......Summary report of a Nordtest workshop on moisture buffer capacity held at Copenhagen August 21-22 2003...

  10. Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons.

    Science.gov (United States)

    Tung, Li-Wei; Lu, Guan-Ling; Lee, Yen-Hsien; Yu, Lung; Lee, Hsin-Jung; Leishman, Emma; Bradshaw, Heather; Hwang, Ling-Ling; Hung, Ming-Shiu; Mackie, Ken; Zimmer, Andreas; Chiou, Lih-Chu

    2016-01-01

    Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress in mice activates lateral hypothalamic (LH) orexin neurons, increases levels of orexin A and 2-arachidonoylglycerol (2-AG) in the ventral tegmental area (VTA), and reinstates extinguished cocaine-conditioned place preference (CPP). This stress-induced reinstatement of cocaine CPP depends on type 1 orexin receptors (OX1Rs), type 1 cannabinoid receptors (CB1Rs) and diacylglycerol lipase (DAGL) in the VTA. In dopaminergic neurons of VTA slices, orexin A presynaptically inhibits GABAergic transmission. This effect is prevented by internal GDP-β-S or inhibiting OX1Rs, CB1Rs, phospholipase C or DAGL, and potentiated by inhibiting 2-AG degradation. These results suggest that restraint stress activates LH orexin neurons, releasing orexins into the VTA to activate postsynaptic OX1Rs of dopaminergic neurons and generate 2-AG through a Gq-protein-phospholipase C-DAGL cascade. 2-AG retrogradely inhibits GABA release through presynaptic CB1Rs, leading to VTA dopaminergic disinhibition and reinstatement of cocaine CPP. PMID:27448020

  11. Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

    Science.gov (United States)

    Tung, Li-Wei; Lu, Guan-Ling; Lee, Yen-Hsien; Yu, Lung; Lee, Hsin-Jung; Leishman, Emma; Bradshaw, Heather; Hwang, Ling-Ling; Hung, Ming-Shiu; Mackie, Ken; Zimmer, Andreas; Chiou, Lih-Chu

    2016-01-01

    Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress in mice activates lateral hypothalamic (LH) orexin neurons, increases levels of orexin A and 2-arachidonoylglycerol (2-AG) in the ventral tegmental area (VTA), and reinstates extinguished cocaine-conditioned place preference (CPP). This stress-induced reinstatement of cocaine CPP depends on type 1 orexin receptors (OX1Rs), type 1 cannabinoid receptors (CB1Rs) and diacylglycerol lipase (DAGL) in the VTA. In dopaminergic neurons of VTA slices, orexin A presynaptically inhibits GABAergic transmission. This effect is prevented by internal GDP-β-S or inhibiting OX1Rs, CB1Rs, phospholipase C or DAGL, and potentiated by inhibiting 2-AG degradation. These results suggest that restraint stress activates LH orexin neurons, releasing orexins into the VTA to activate postsynaptic OX1Rs of dopaminergic neurons and generate 2-AG through a Gq-protein-phospholipase C-DAGL cascade. 2-AG retrogradely inhibits GABA release through presynaptic CB1Rs, leading to VTA dopaminergic disinhibition and reinstatement of cocaine CPP. PMID:27448020

  12. Restraint effects on stress-related hormones and blood natural killer cell cytotoxicity in pigs with a mutated ryanodine receptor.

    Science.gov (United States)

    Ciepielewski, Z M; Stojek, W; Glac, W; Wrona, D

    2013-05-01

    A mutation in the ryanodine receptor gene (RYR1) of the calcium release channel is responsible for increased stress susceptibility in pigs. In the present study, the relation of a mutation in RYR1 with the neuroendocrine (stress-related hormone) response and the immune defense represented by natural killer cell cytotoxicity (NKCC) during a 4-h restraint and recovery phase in 60 male pigs was investigated. Blood samples were collected from pigs previously divided into RYR1 genotypes (nn, Nn, NN), based on PCR amplification and restriction analyses. The blood samples collected during the restraint and recovery phases of the experiment were used to determine NKCC ((51)Cr-release assay), large granular lymphocyte number (hematologic method), and plasma concentrations of prolactin (PRL), GH, ACTH, and cortisol (COR) (by specific RIA). The greatest degree of NKCC response (P stress relative to controls was observed for the stress-susceptible homozygote group (nn). Measures of stress-related hormones were positively correlated with NKCC during the entire experimental period (P stress and the recovery phase (480 min), a decrease in immune response was accompanied by an elevated COR response in all RYR1 genotypes. Moreover, divergent responses of both PRL (greatest in nn, P stress-susceptible RYR1-mutated homozygotes develop a greater level of immune defense, including cytotoxic activity of NK cells, and accompanied by more pronounced stress-induced changes in neuroendocrine response than stress-resistant heterozygous (Nn) and homozygous (NN) pigs.

  13. Capacities on a finite lattice

    OpenAIRE

    Machida, Motoya

    2011-01-01

    In his influential work Choquet systematically studied capacities on Boolean algebras in a topological space, and gave a probabilistic interpretation for completely monotone (and completely alternating) capacities. Beyond complete monotonicity we can view a capacity as a marginal condition for probability distribution over the distributive lattice of dual order ideals. In this paper we discuss a combinatorial approach when capacities are defined over a finite lattice, and investigate Fr\\'{e}c...

  14. Landfill Construction and Capacity Expansion

    NARCIS (Netherlands)

    Andre, F.J.; Cerda, E.

    2003-01-01

    We study the optimal capacity and lifetime of landfills taking into account their sequential nature.Such an optimal capacity is characterized by the so-called Optimal Capacity Condition.Particular versions of this condition are obtained for two alternative settings: first, if all the landfills are t

  15. Competitive Capacity Investment under Uncertainty

    NARCIS (Netherlands)

    X. Li (Xishu); R.A. Zuidwijk (Rob); M.B.M. de Koster (René); R. Dekker (Rommert)

    2016-01-01

    textabstractWe consider a long-term capacity investment problem in a competitive market under demand uncertainty. Two firms move sequentially in the competition and a firm’s capacity decision interacts with the other firm’s current and future capacity. Throughout the investment race, a firm can eith

  16. Why marathon migrants get away with high metabolic ceilings : towards an ecology of physiological restraint

    NARCIS (Netherlands)

    Piersma, Theunis

    2011-01-01

    Animals usually are not willing to perform at levels, or for lengths of time, of which they should be maximally capable. In stating this, exercise performance and inferred capacity are gauged with respect to body size and the duration of particular levels of energy expenditure. In such relative term

  17. Why marathon migrants get away with high metabolic ceilings: towards an ecology of physiological restraint

    NARCIS (Netherlands)

    Piersma, T.

    2011-01-01

    Animals usually are not willing to perform at levels, or for lengths of time, of which they should be maximally capable. In stating this, exercise performance and inferred capacity are gauged with respect to body size and the duration of particular levels of energy expenditure. In such relative term

  18. What factors influence mitigative capacity?

    International Nuclear Information System (INIS)

    This article builds on Yohe's seminal piece on mitigative capacity, which elaborates 'determinants' of mitigative capacity, also reflected in the IPCC's third assessment report. We propose a revised definition, where mitigative capacity is a country's ability to reduce anthropogenic greenhouse gas emissions or enhance natural sinks. By 'ability' we mean skills, competencies, fitness, and proficiencies that a country has attained which can contribute to GHG emissions mitigation. A conceptual framework is proposed, linking mitigative capacity to a country's sustainable development path, and grouping the factors influencing mitigative capacity into three main sets: economic factors, institutional ones, and technology. Both quantitative and qualitative analysis of factors is presented, showing how these factors vary across countries. We suggest that it is the interplay between the three economic factors-income, abatement cost and opportunity cost-that shape mitigative capacity. We find that income is an important economic factor influencing mitigative capacity, while abatement cost is important in turning mitigative capacity into actual mitigation. Technology is a critical mitigative capacity, including the ability to absorb existing climate-friendly technologies or to develop innovative ones. Institutional factors that promote mitigative capacity include the effectiveness of government regulation, clear market rules, a skilled work force and public awareness. We briefly investigate such as high abatement cost or lack of political willingness that prevent mitigative capacity from being translated into mitigation

  19. Capacity building for HIA

    Directory of Open Access Journals (Sweden)

    Gabriel Gulis PhD

    2007-09-01

    Full Text Available

    Background: To integrate health impact assessment (HIA into existing decision-making processes requires not only methods and procedures but also well-trained experts, aware policy makers and appropriate institutions. Capacity building is the assistance which is provided to entities, which have a need to develop a certain skill or competence, or for general upgrading of performance ability. If a new technique is planned to be introduced there is a need for capacity building with no respect to levels (local, regional, national, international or sectors (health, environment, finance, social care, education, etc.. As such, HIA is a new technique for most of the new Member States and accession countries of the European Union.

    Methods: To equip individuals with the understanding and skills needed to launch a HIA or be aware of the availability of this methodology and to access information, knowledge and training, we focused on the organization of workshops in participating countries. The workshops served also as pilot events to test a “curriculum” for HIA; a set of basic topics and presentations had been developed to be tested during workshops. In spite of classical in-class workshops we aimed to organize e-learning events as a way to over come the “busyness” problem of decision makers.

    Results: Throughout March – October 2006 we organized and ran 7 workshops in Denmark, Turkey, Lithuania, Poland, Bulgaria, Slovak Republic and Hungary. Participants came from the public health sector (141, non-public health decision makers (113 and public health students (100. A concise curriculum was developed and tested during these workshops. Participants developed a basic understanding of HIA, skills to develop and use their own screening tools as well as scoping.Within the workshop in Denmark we tested an online, real-time Internet based training method; participants highly welcomed this

  20. Quantum Reading Capacity

    CERN Document Server

    Pirandola, Stefano; Giovannetti, Vittorio; Mancini, Stefano; Braunstein, Samuel L

    2011-01-01

    The readout of a classical memory can be modelled as a problem of quantum channel discrimination, where a decoder retrieves information by distinguishing the different quantum channels encoded in each cell of the memory [S. Pirandola, Phys. Rev. Lett. 106, 090504 (2011)]. In the case of optical memories, such as CDs and DVDs, this discrimination involves lossy bosonic channels and can be remarkably boosted by the use of nonclassical light (quantum reading). Here we generalize these concepts by extending the model of memory from single-cell to multi-cell encoding. In general, information is stored in a block of cells by using a channel-codeword, i.e., a sequence of channels chosen according to a classical code. Correspondingly, the readout of data is realized by a process of "parallel" channel discrimination, where the entire block of cells is probed simultaneously and decoded via an optimal collective measurement. In the limit of an infinite block we define the quantum reading capacity of the memory, quantify...

  1. Restraint increases prolactin and REM sleep in C57BL/6J mice but not in BALB/cJ mice

    NARCIS (Netherlands)

    Meerlo, Peter; Easton, Amy; Bergmann, Bernard M.; Turek, Fred W.

    2001-01-01

    Sleep is generally considered to be a recovery from prior wakefulness. The architecture of sleep not only depends on the duration of wakefulness but also on its quality in terms of specific experiences. In the present experiment, we studied the effects of restraint stress on sleep architecture and s

  2. Restraining good practice: Reviewing evidence of the effects of restraint from the perspective of service users and mental health professionals in the United Kingdom (UK).

    Science.gov (United States)

    Cusack, P; McAndrew, S; Cusack, F; Warne, T

    2016-01-01

    Safeguarding, balancing the concept of risk with the need for public protection and its implication for the lives of individuals, is an important facet of contemporary mental health care. Integral to safeguarding is the protection of human rights; the right to live free from torture, inhuman, or degrading treatment, and having the right to liberty, security, respect, and privacy. Professionals are required to recognise all of these rights when delivering care to vulnerable people. In the United Kingdom (UK) there has been growing public concern regarding abusive practices in institutions, with a number of unacceptable methods of restraint being identified as a feature of care, particularly in mental health care. In keeping with the service user movement, and following a review of the literature, this paper discusses the evidence regarding restraint from the perspectives of service users and professionals within mental health services and considers the implications for future practice and research. In reviewing the literature, findings revealed that restraint can be a form of abuse, it's inappropriate use often being a consequence of fear, neglect, and lack of using de-escalation techniques. Using restraint in this way can have negative implications for the well-being of service users and mental health professionals alike. PMID:27067763

  3. Evaluation of the protective effects of tocotrienol-rich fraction from palm oil on the dentate gyrus following chronic restraint stress in rats

    Directory of Open Access Journals (Sweden)

    Saiful Bhari Talip

    2013-06-01

    Full Text Available Exposure to chronic restraint stress has been shown to cause a number of morphological changes in the hippocampal formation of rats. Tocotrienol, an isoform of vitamin E, exhibits numerous health benefits, different from those of tocopherol. Recent studies have demonstrated that tocotrienol prevents stress-induced changes in the gastric mucosa, thus indicating that it may also protect other organs such as the brain from the damaging effects of stress. Therefore, the aim of the present study was to investigate the protective effect of tocotrienol-rich fraction (TRF extracted from palm oil on the dentate gyrus of rats following exposure to chronic restraint stress. Thirty-six male Sprague Dawley rats were divided into four groups: control, stress, tocotrienol and combination of stress and tocotrienol. Animals were stressed by restraining them for 5 hours every day for 21 consecutive days. TRF was administered via oral gavage at a dose of 200 mg/kg body weight. Our results showed that the plasma corticosterone level was significantly increased in response to stress, compared to the control. The results confirmed previous findings that chronic restraint stress suppresses cellular proliferation and reduces granule cell number in the dentate gyrus. However, TRF supplementation failed to prevent or minimize these stress-induced changes. Therefore, we conclude that TRF at the current dosage is not effective in preventing the morphological changes in the dentate gyrus induced by chronic restraint stress.

  4. Impact of eLearning course on nurses' professional competence in seclusion and restraint practices: a randomized controlled study (ISRCTN32869544).

    Science.gov (United States)

    Kontio, R; Lahti, M; Pitkänen, A; Joffe, G; Putkonen, H; Hätönen, H; Katajisto, J; Välimäki, M

    2011-11-01

    Education on the care of aggressive and disturbed patients is fragmentary. eLearning could ensure the quality of such education, but data on its impact on professional competence in psychiatry are lacking. The aim of this study was to explore the impact of ePsychNurse.Net, an eLearning course, on psychiatric nurses' professional competence in seclusion and restraint and on their job satisfaction and general self-efficacy. In a randomized controlled study, 12 wards were randomly assigned to ePsychNurse.Net (intervention) or education as usual (control). Baseline and 3-month follow-up data on nurses' knowledge of coercion-related legislation, physical restraint and seclusion, their attitudes towards physical restraint and seclusion, job satisfaction and general self-efficacy were analysed for 158 completers. Knowledge (primary outcome) of coercion-related legislation improved in the intervention group, while knowledge of physical restraint improved and knowledge of seclusion remained unchanged in both groups. General self-efficacy improved in the intervention group also attitude to seclusion in the control group. In between-group comparison, attitudes to seclusion (one of secondary outcomes) favoured the control group. Although the ePsychNurse.Net demonstrated only slight advantages over conventional learning, it may be worth further development with, e.g. flexible time schedule and individualized content. PMID:21985684

  5. Modulatory influence of rarely repeated of immobilization episodes on the interleukin-1β-dependent reaction of blood leukocytes and hepatoprotective effect of restraint stress.

    Science.gov (United States)

    Tseilikman, O B; Tseilikman, V E; Linin, A V; Gubkin, D A; Rudina, E A; Trubetskoy, S A; Ivanov, P V; Pozdnyakov, E A

    2011-02-01

    Repeated episodes of 1-h restraint stress were accompanied by a decrease in the sensitivity of blood leukocytes and cytochrome P450-dependent monooxygenases of the liver to recombinant IL-1β. These changes are associated with the anti-inflammatory hepatoprotective effect of chronic stress.

  6. Available transmission capacity assessment

    Directory of Open Access Journals (Sweden)

    Škokljev Ivan

    2012-01-01

    Full Text Available Effective power system operation requires the analysis of vast amounts of information. Power market activities expose power transmission networks to high-level power transactions that threaten normal, secure operation of the power system. When there are service requests for a specific sink/source pair in a transmission system, the transmission system operator (TSO must allocate the available transfer capacity (ATC. It is common that ATC has a single numerical value. Additionally, the ATC must be calculated for the base case configuration of the system, while generation dispatch and topology remain unchanged during the calculation. Posting ATC on the internet should benefit prospective users by aiding them in formulating their requests. However, a single numerical value of ATC offers little for prospect for analysis, planning, what-if combinations, etc. A symbolic approach to the power flow problem (DC power flow and ATC offers a numerical computation at the very end, whilst the calculation beforehand is performed by using symbols for the general topology of the electrical network. Qualitative analysis of the ATC using only qualitative values, such as increase, decrease or no change, offers some new insights into ATC evaluation, multiple transactions evaluation, value of counter-flows and their impact etc. Symbolic analysis in this paper is performed after the execution of the linear, symbolic DC power flow. As control variables, the mathematical model comprises linear security constraints, ATC, PTDFs and transactions. The aim is to perform an ATC sensitivity study on a five nodes/seven lines transmission network, used for zonal market activities tests. A relatively complicated environment with twenty possible bilateral transactions is observed.

  7. Perioperative functional residual capacity.

    Science.gov (United States)

    Wahba, R W

    1991-04-01

    The literature dealing with the magnitude, mechanism and effects of reduced FRC in the perioperative period is reviewed. During general anaesthesia FRC is reduced by approximately 20%. The reduction is greater in the obese and in patients with COPD. The most likely mechanism is the loss of inspiratory muscle tone of the muscles acting on the rib cage. Gas trapping is an additional mechanism. Lung compliance decreases and airways resistance increases, in large part, due to decreased FRC. The larynx is displaced anteriorly and elongated, making laryngoscopy and intubation more difficult. The change in FRC creates or increases intrapulmonary shunt and areas of low ventilation to perfusion. This is due to the occurrence of compression atelectasis, and to regional changes in mechanics and airway closure which tend to reduce ventilation to dependent lung zones which are still well perfused. Abdominal and thoracic operations tend to increase shunting further. Large tidal volume but not PEEP will improve oxygenation, although both increase FRC. Both FRC and vital capacity are reduced following abdominal and thoracic surgery in a predictable pattern. The mechanism is the combined effect of incisional pain and reflex dysfunction of the diaphragm. Additional effects of thoracic surgery include pleural effusion, cooling of the phrenic nerve and mediastinal widening. Postoperative hypoxaemia is a function of reduced FRC and airway closure. There is no real difference among the various methods of active lung expansion in terms of the speed of restoration of lung function, or in preventing postoperative atelectasis/pneumonia. Epidural analgesia does not influence the rate of recovery of lung function, nor does it prevent atelectasis/pneumonia. PMID:2036700

  8. On the NMR structure determination of a 44n RNA pseudoknot: Assignment strategies and derivation of torsion angle restraints

    Energy Technology Data Exchange (ETDEWEB)

    Kolk, Michael H. [University of Nijmegen, Toernooiveld, NSR Center for Molecular Structure, Design and Synthesis, Laboratory of Biophysical Chemistry (Netherlands); Wijmenga, Sybren S. [University of Umea, Department of Medical Biochemistry and Biophysics (Sweden); Heus, Hans A.; Hilbers, Cornelis W. [University of Nijmegen, Toernooiveld, NSR Center for Molecular Structure, Design and Synthesis, Laboratory of Biophysical Chemistry (Netherlands)

    1998-10-15

    The complete T- and pseudoknotted acceptor arm of the tRNA-like structure of turnip yellow mosaic virus (TYMV) genomic RNA has been studied by NMR spectroscopy. Resonance assignment and the gathering of restraints of the 44-mer are impeded by spectral complexity as well as by line broadening. The latter is caused by local dynamical effects in the pseudoknot domain in the molecule. These specific problems could be solved by using different field strengths and selectively {sup 13}C/{sup 15} labeled samples. Experiments for assigning the sugar spin systems were adjusted to satisfy the requirements of this system. Furthermore, the quality of the structure could be improved by determining the backbone torsion angles {beta}, {gamma} and {epsilon}, using new approaches that were tailored for use in large RNA molecules.

  9. Comparing the effect of non-medical mechanical restraint preventive factors between psychiatric units in Denmark and Norway

    DEFF Research Database (Denmark)

    Bak, Jesper; Zoffmann, V.; Sestoft, D.M.;

    2015-01-01

    -medical origin may explain the differing number of MR episodes between Denmark and Norway. METHODS: This study is a cross-sectional survey of psychiatric units. Linear regression was used to assess the confounding effects of the MR preventive factors, i.e. whether a difference in the impact of these factors......BACKGROUND: The use of mechanical restraint (MR) is controversial, and large differences regarding the use of MR are often found among countries. In an earlier study, we observed that MR was used twice as frequently in Denmark than Norway. AIMS: To examine how presumed MR preventive factors of non......-staff ratio (- 11%), and the identification of the patient's crisis triggers (- 10%). CONCLUSIONS: These six MR preventive factors might partially explain the difference in the frequency of MR episodes observed in the two countries, i.e. higher numbers in Denmark than Norway. One MR preventive factor...

  10. 政治权力的约束与腐败治理%Political Power Restraint and Anti-Corruption

    Institute of Scientific and Technical Information of China (English)

    张翔鸢

    2014-01-01

    Power restraint should be temperate,and should follow three reasonable paths:the power path,the law path, and the society path. Anti-corruption not only should grasp typical cases,but also should set up a long term mechanism of preventing and administrating corruption.%权力约束应遵循适度原则,并且有三个可循的路径,即权力的路径、法律的路径和社会的路径。腐败治理既要抓典型,又要建立防腐治腐的长效机制。

  11. Competitive Capacity Investment under Uncertainty

    OpenAIRE

    Li, Xishu; Zuidwijk, Rob; Koster, René; Dekker, Rommert

    2016-01-01

    textabstractWe consider a long-term capacity investment problem in a competitive market under demand uncertainty. Two firms move sequentially in the competition and a firm’s capacity decision interacts with the other firm’s current and future capacity. Throughout the investment race, a firm can either choose to plan its investments proactively, taking into account possible responses from the other firm, or decide to respond reactively to the competition. In both cases, the optimal decision at...

  12. Behavioral and autonomic responses to acute restraint stress are segregated within the lateral septal area of rats.

    Directory of Open Access Journals (Sweden)

    Daniel G Reis

    Full Text Available BACKGROUND: The Lateral Septal Area (LSA is involved with autonomic and behavior responses associated to stress. In rats, acute restraint (RS is an unavoidable stress situation that causes autonomic (body temperature, mean arterial pressure (MAP and heart rate (HR increases and behavioral (increased anxiety-like behavior changes in rats. The LSA is one of several brain regions that have been involved in stress responses. The aim of the present study was to investigate if the neurotransmission blockade in the LSA would interfere in the autonomic and behavioral changes induced by RS. METHODOLOGY/PRINCIPAL FINDINGS: Male Wistar rats with bilateral cannulae aimed at the LSA, an intra-abdominal datalogger (for recording internal body temperature, and an implanted catheter into the femoral artery (for recording and cardiovascular parameters were used. They received bilateral microinjections of the non-selective synapse blocker cobalt chloride (CoCl(2, 1 mM/ 100 nL or vehicle 10 min before RS session. The tail temperature was measured by an infrared thermal imager during the session. Twenty-four h after the RS session the rats were tested in the elevated plus maze (EPM. CONCLUSIONS/SIGNIFICANCE: Inhibition of LSA neurotransmission reduced the MAP and HR increases observed during RS. However, no changes were observed in the decrease in skin temperature and increase in internal body temperature observed during this period. Also, LSA inhibition did not change the anxiogenic effect induced by RS observed 24 h later in the EPM. The present results suggest that LSA neurotransmission is involved in the cardiovascular but not the temperature and behavioral changes induced by restraint stress.

  13. Use of secondary structural information and C-C distance restraints to model protein structures with MODELLER

    Indian Academy of Sciences (India)

    Boojala V B Reddy; Yiannis N Kaznessis

    2007-08-01

    Protein secondary structure predictions and amino acid long range contact map predictions from primary sequence of proteins have been explored to aid in modelling protein tertiary structures. In order to evaluate the usefulness of secondary structure and 3D-residue contact prediction methods to model protein structures we have used the known Q3 (alpha-helix, beta-strands and irregular turns/loops) secondary structure information, along with residue-residue contact information as restraints for MODELLER. We present here results of our modelling studies on 30 best resolved single domain protein structures of varied lengths. The results shows that it is very difficult to obtain useful models even with 100% accurate secondary structure predictions and accurate residue contact predictions for up to 30% of residues in a sequence. The best models that we obtained for proteins of lengths 37, 70, 118, 136 and 193 amino acid residues are of RMSDs 4.17, 5.27, 9.12, 7.89 and 9.69, respectively. The results show that one can obtain better models for the proteins which have high percent of alpha-helix content. This analysis further shows that MODELLER restrain optimization program can be useful only if we have truly homologous structure(s) as a template where it derives numerous restraints, almost identical to the templates used. This analysis also clearly indicates that even if we satisfy several true residue-residue contact distances, up to 30% of their sequence length with fully known secondary structural information, we end up predicting model structures much distant from their corresponding native structures.

  14. RosettaTMH: a method for membrane protein structure elucidation combining EPR distance restraints with assembly of transmembrane helices

    Directory of Open Access Journals (Sweden)

    Andrew Leaver-Fay

    2015-12-01

    Full Text Available Membrane proteins make up approximately one third of all proteins, and they play key roles in a plethora of physiological processes. However, membrane proteins make up less than 2% of experimentally determined structures, despite significant advances in structure determination methods, such as X-ray crystallography, nuclear magnetic resonance spectroscopy, and cryo-electron microscopy. One potential alternative means of structure elucidation is to combine computational methods with experimental EPR data. In 2011, Hirst and others introduced RosettaEPR and demonstrated that this approach could be successfully applied to fold soluble proteins. Furthermore, few computational methods for de novo folding of integral membrane proteins have been presented. In this work, we present RosettaTMH, a novel algorithm for structure prediction of helical membrane proteins. A benchmark set of 34 proteins, in which the proteins ranged in size from 91 to 565 residues, was used to compare RosettaTMH to Rosetta’s two existing membrane protein folding protocols: the published RosettaMembrane folding protocol (“MembraneAbinitio” and folding from an extended chain (“ExtendedChain”. When EPR distance restraints are used, RosettaTMH+EPR outperforms ExtendedChain+EPR for 11 proteins, including the largest six proteins tested. RosettaTMH+EPR is capable of achieving native-like folds for 30 of 34 proteins tested, including receptors and transporters. For example, the average RMSD100SSE relative to the crystal structure for rhodopsin was 6.1 ± 0.4 Å and 6.5 ± 0.6 Å for the 449-residue nitric oxide reductase subunit B, where the standard deviation reflects variance in RMSD100SSE values across ten different EPR distance restraint sets. The addition of RosettaTMH and RosettaTMH+EPR to the Rosetta family of de novo folding methods broadens the scope of helical membrane proteins that can be accurately modeled with this software suite.

  15. Chronic exercise prevents repeated restraint stress-provoked enhancement of immobility in forced swimming test in ovariectomized mice.

    Science.gov (United States)

    Han, Tae-Kyung; Lee, Jang-Kyu; Leem, Yea-Hyun

    2015-06-01

    We assessed whether chronic treadmill exercise attenuated the depressive phenotype induced by restraint stress in ovariectomized mice (OVX). Immobility of OVX in the forced swimming test was comparable to that of sham mice (CON) regardless of the postoperative time. Immobility was also no difference between restrained mice (exposure to periodic restraint for 21 days; RST) and control mice (CON) on post-exposure 2nd and 9th day, but not 15th day. In contrast, the immobility of ovariectomized mice with repeated stress (OVX + RST) was profoundly enhanced compared to ovariectomized mice-alone (OVX), and this effect was reversed by chronic exercise (19 m/min, 60 min/day, 5 days/week for 8 weeks; OVX + RST + Ex) or fluoxetine administration (20 mg/kg, OVX + RST + Flu). In parallel with behavioral data, the immunoreactivity of Ki-67 and doublecortin (DCX) in OVX was significantly decreased by repeated stress. However, the reduced numbers of Ki-67- and DCX-positive cells in OVX + RST were restored in response to chronic exercise (OVX + RST + Ex) and fluoxetine (OVX + RST + Flu). In addition, the expression pattern of cAMP response element-binding protein (CREB) and calcium-calmodulin-dependent kinase IV (CaMKIV) was similar to that of the hippocampal proliferation and neurogenesis markers (Ki-67 and DCX, respectively). These results suggest that menopausal depression may be induced by an interaction between repeated stress and low hormone levels, rather than a deficit in ovarian secretion alone, which can be improved by chronic exercise.

  16. Capacity Measurement with the UIC 406 Capacity Method

    DEFF Research Database (Denmark)

    Landex, Alex; Schittenhelm, Bernd; Kaas, Anders H.;

    2008-01-01

    This article describes the fast and effective UIC 406 method for calculating capacity consumption on railway lines. It is possible to expound the UIC 406 method in different ways which can lead to different capacity consumptions. Therefore, this article describes how the methodology is expounded ...

  17. Information capacity of quantum observable

    OpenAIRE

    Holevo, A. S.

    2011-01-01

    In this paper we consider the classical capacities of quantum-classical channels corresponding to measurement of observables. Special attention is paid to the case of continuous observables. We give the formulas for unassisted and entanglement-assisted classical capacities $C,C_{ea}$ and consider some explicitly solvable cases which give simple examples of entanglement-breaking channels with $C

  18. Information capacity of quantum observable

    CERN Document Server

    Holevo, A S

    2011-01-01

    In this paper we consider the classical capacities of quantum-classical channels corresponding to measurement of observables. Special attention is paid to the case of continuous observables. We give the formulas for unassisted and entanglement-assisted classical capacities $C,C_{ea}$ and consider some explicitly solvable cases which give new examples of entanglement-breaking channels with $C_{ea}>C.$

  19. Capacity Utilization in European Railways

    DEFF Research Database (Denmark)

    Khadem Sameni, Melody; Landex, Alex

    2013-01-01

    At the strategic level, railways currently use different indices to estimate how ‘value’ is generated by using railway capacity. However, railway capacity is a multidisciplinary area, and attempts to develop various indices cannot provide a holistic measure of operational efficiency. European rai...

  20. Capacity Building in Land Administration

    DEFF Research Database (Denmark)

    Enemark, Stig; Williamson, I

    2004-01-01

    Capacity building increasingly seen as a key component of land administration projects in developing and countries in transition undertaken by the international development banks and individual country development assistance agencies. However, the capacity building concept is often used within...... infrastructures for implementing land policies in a sustainable way. Where a project is established to create land administration infrastructures in developing or transition countries, it is critical that capacity building is a mainstream component, not as an add-on, which is often the case. In fact such projects...... should be dealt with as capacity building projects in themselves.    The article introduces a conceptual analytical framework that provides some guidance when dealing with capacity building for land administration in support of a broader land policy agenda....

  1. Capacity Building in Land Management

    DEFF Research Database (Denmark)

    Enemark, Stig; Ahene, Rexford

    2003-01-01

    There is a significant need for capacity building in the interdisciplinary area of land management especially in developing countries and countries in transition, to deal with the complex issues of building efficient land information systems and sustainable institutional infrastructures. Capacity...... building in land management is not only a question of establishing a sufficient technological level or sufficient economic resources. It is mainly a question of understanding the interdisciplinary and cross-sectoral nature of land administration systems, and understanding the need for human resource...... development in this area. Furthermore, capacity building should ensure that the focus is on building sound institutions and governance rather than just high-level IT-infrastructures.    This overall approach to capacity building in land management is used for implementing a new land policy reform in Malawi...

  2. Quantum channel capacities - multiparty communication

    CERN Document Server

    Demianowicz, M; Demianowicz, Maciej; Horodecki, Pawel

    2006-01-01

    We analyze different aspects of multiparty communication over quantum memoryless channels and generalize some of key results known from bipartite channels to that of multiparty scenario. In particular, we introduce multiparty versions of minimal subspace transmission fidelity and entanglement transmission fidelity. We also provide alternative, local, versions of fidelities and show their equivalence to the global ones in context of capacity regions defined. The equivalence of two different capacity notions with respect to two types of the fidelities is proven. In analogy to bipartite case it is shown, via sufficiency of isometric encoding theorem, that additional classical forward side channel does not increase capacity region of any quantum channel with $k$ senders and $m$ receivers which represents a compact unit of general quantum networks theory. The result proves that recently provided capacity region of multiple access channel ([M. Horodecki et al, Nature {\\bf 436} 673 (2005)], [J.Yard et al, quant-ph/0...

  3. Warfare, Fiscal Capacity, and Performance

    DEFF Research Database (Denmark)

    Prado, Mauricio; Dincecco, Mark

    We exploit differences in casualties sustained in pre-modern wars to estimate the impact of fiscal capacity on economic performance. In the past, states fought different amounts of external conflicts, of various lengths and magnitudes. To raise the revenues to wage wars, states made fiscal innova...... estimate substantial impacts of fiscal capacity on GDP per worker. The results are robust to a broad range of specifications, controls, and sub-samples.......We exploit differences in casualties sustained in pre-modern wars to estimate the impact of fiscal capacity on economic performance. In the past, states fought different amounts of external conflicts, of various lengths and magnitudes. To raise the revenues to wage wars, states made fiscal...... innovations, which persisted and helped to shape current fiscal institutions. Economic historians claim that greater fiscal capacity was the key long-run institutional change brought about by historical conflicts. Using casualties sustained in pre-modern wars to instrument for current fiscal institutions, we...

  4. Warfare, Fiscal Capacity, and Performance

    DEFF Research Database (Denmark)

    Dincecco, Mark; Prado, Mauricio

    2012-01-01

    We exploit differences in casualties sustained in pre-modern wars to estimate the impact of fiscal capacity on economic performance. In the past, states fought different amounts of external conflicts, of various lengths and magnitudes. To raise the revenues to wage wars, states made fiscal innova...... estimate substantial impacts of fiscal capacity on GDP per worker. The results are robust to a broad range of specifications, controls, and sub-samples.......We exploit differences in casualties sustained in pre-modern wars to estimate the impact of fiscal capacity on economic performance. In the past, states fought different amounts of external conflicts, of various lengths and magnitudes. To raise the revenues to wage wars, states made fiscal...... innovations, which persisted and helped to shape current fiscal institutions. Economic historians claim that greater fiscal capacity was the key long-run institutional change brought about by historical conflicts. Using casualties sustained in pre-modern wars to instrument for current fiscal institutions, we...

  5. Capacity Analysis on Multi-Lane Roundabouts: An Evaluation With Highway Capacity Manual 2010 Capacity Model

    Directory of Open Access Journals (Sweden)

    Melike Ersoy

    2014-06-01

    Full Text Available In this study, capacity estimations with the incorporation of Highway Capacity Manual (HCM 2010 method are evaluated. Parameter based sensitivity analysis on calculations with the new HCM formula and a comparative evaluation of the new methodology with two most common capacity analysis methods, i.e., the method of critical gap acceptance and the method of regression analysis, are performed. Maximum and minimum headway intervals of follow up time and critical gap parameters are alternated within the sensitivity analysis. The Transport Research Laboratory formula for regression and Australian formula for gap acceptance method are considered in comparison. Relative comparisons of predictions on capacity by HCM2010 method, regression analysis and gap acceptance method are presented considering field data obtained by observations at two roundabouts in Izmir, Turkey. The results of the study show that the HCM2010 formula led to lower capacity estimates than regression analysis and higher estimates than the gap acceptance method. Regarding the real capacity observations under high circulating flow-rates the HCM2010 method yielded to more appropriate results than the regression method. In addition to comparisons, studies on the sensitivity analysis show that entry capacity estimates possess sharper changes as smaller follow up headways are accepted.

  6. Affine transformations and analytic capacities

    OpenAIRE

    Dowling, Thomas; O'Farrell, Anthony G.

    1995-01-01

    Analytic capacities are set functions defined on the plane which may be used in the study of removable singularities, boundary smoothness and approximation of analytic functions belonging to some function space. The symmetric concrete Banach spaces form a class of function spaces that include most spaces usually studied. The Beurling transform is a certain singular integral operator that has proved useful in analytic function theory. It is shown that the analytic capacity associated to ...

  7. Capacity achieving multiwrite WOM codes

    OpenAIRE

    Shpilka, Amir

    2012-01-01

    In this paper we give an explicit construction of a capacity achieving family of binary t-write WOM codes for any number of writes t, that have a polynomial time encoding and decoding algorithms. The block length of our construction is N=(t/\\epsilon)^{O(t/(\\delta\\epsilon))} when \\epsilon is the gap to capacity and encoding and decoding run in time N^{1+\\delta}. This is the first deterministic construction achieving these parameters. Our techniques also apply to larger alphabets.

  8. Carrying Capacity:An Overview

    Institute of Scientific and Technical Information of China (English)

    Chen Shaofeng

    2004-01-01

    The concept of carrying capacity is derived from ecology, with widespread contentions of its theoretical connotations and applications in the international academic community, especially the impact of human activities on the environment.Disputes on carrying capacity have been occurring not only among biologists and ecologists, but also among mainstream economists. Based on their efforts,the author makes an attempt to describe its origin,connotations, problems, measurement, and at the same time note the latest international progress in this field.

  9. Maximizing the optical network capacity.

    Science.gov (United States)

    Bayvel, Polina; Maher, Robert; Xu, Tianhua; Liga, Gabriele; Shevchenko, Nikita A; Lavery, Domaniç; Alvarado, Alex; Killey, Robert I

    2016-03-01

    Most of the digital data transmitted are carried by optical fibres, forming the great part of the national and international communication infrastructure. The information-carrying capacity of these networks has increased vastly over the past decades through the introduction of wavelength division multiplexing, advanced modulation formats, digital signal processing and improved optical fibre and amplifier technology. These developments sparked the communication revolution and the growth of the Internet, and have created an illusion of infinite capacity being available. But as the volume of data continues to increase, is there a limit to the capacity of an optical fibre communication channel? The optical fibre channel is nonlinear, and the intensity-dependent Kerr nonlinearity limit has been suggested as a fundamental limit to optical fibre capacity. Current research is focused on whether this is the case, and on linear and nonlinear techniques, both optical and electronic, to understand, unlock and maximize the capacity of optical communications in the nonlinear regime. This paper describes some of them and discusses future prospects for success in the quest for capacity. PMID:26809572

  10. Restraint stress and repeated CRF receptor activation in the amygdala both increase amyloid β precursor protein (APP) and amyloid-β (Aβ) peptide but have divergent effects on BDNF and pre-synaptic proteins in the prefrontal cortex of rats

    OpenAIRE

    Ray, Balmiki; Gaskins, Denise L.; Sajdyk, Tammy J.; Spence, John P.; Fitz, Stephanie D.; Shekhar, Anantha; Lahiri, Debomoy K.

    2011-01-01

    Both environmental stress and anxiety may represent important risk factors for Alzheimer's disease (AD) pathogenesis. Previous studies demonstrate that restraint stress is associated with increased amyloid beta (Aβ) and decreased brain-derived neurotrophic factor (BDNF) levels in the brain. Aβ deposition, synaptic loss, and neurodegeneration define major hallmarks of AD, and BDNF is responsible for the maintenance of neurons. In contrast to restraint stress, repeated injections of sub-anxioge...

  11. The Effects of Oxytocin on Cognitive Defect Caused by Chronic Restraint Stress Applied to Adolescent Rats and on Hippocampal VEGF and BDNF Levels

    OpenAIRE

    Dayi, Ayfer; Cetin, Ferihan; Sisman, Ali Riza; Aksu, Ilkay; Tas, Aysegul; Gönenc, Sevil; Uysal, Nazan

    2015-01-01

    Background Because brain development continues during adolescence, the effects of chronic stress on hippocampal changes that occur during that period are permanent. Oxytocin, which is synthesized in the hypothalamus and has many receptors in brain regions, including the hippocampus, may affect learning-memory. This study aimed to investigate chronic restraint stress on hippocampal functions, and hippocampal vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF)...

  12. Focusing on media body ideal images triggers food intake among restrained eaters: a test of restraint theory and the elaboration likelihood model.

    Science.gov (United States)

    Boyce, Jessica A; Kuijer, Roeline G

    2014-04-01

    Although research consistently shows that images of thin women in the media (media body ideals) affect women negatively (e.g., increased weight dissatisfaction and food intake), this effect is less clear among restrained eaters. The majority of experiments demonstrate that restrained eaters - identified with the Restraint Scale - consume more food than do other participants after viewing media body ideal images; whereas a minority of experiments suggest that such images trigger restrained eaters' dietary restraint. Weight satisfaction and mood results are just as variable. One reason for these inconsistent results might be that different methods of image exposure (e.g., slideshow vs. film) afford varying levels of attention. Therefore, we manipulated attention levels and measured participants' weight satisfaction and food intake. We based our hypotheses on the elaboration likelihood model and on restraint theory. We hypothesised that advertent (i.e., processing the images via central routes of persuasion) and inadvertent (i.e., processing the images via peripheral routes of persuasion) exposure would trigger differing degrees of weight dissatisfaction and dietary disinhibition among restrained eaters (cf. restraint theory). Participants (N = 174) were assigned to one of four conditions: advertent or inadvertent exposure to media or control images. The dependent variables were measured in a supposedly unrelated study. Although restrained eaters' weight satisfaction was not significantly affected by either media exposure condition, advertent (but not inadvertent) media exposure triggered restrained eaters' eating. These results suggest that teaching restrained eaters how to pay less attention to media body ideal images might be an effective strategy in media-literary interventions.

  13. Attenuation by a sigma1 (σ1) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

    OpenAIRE

    Meunier, Johann; Gué, Michèle; Récasens, Max; Maurice, Tangui

    2004-01-01

    Stress during pregnancy results in complex neurochemical and behavioral alterations throughout the offspring lifetime. We here examined the impact of prenatal stress (PS) on memory functions in male and female offspring and report the efficacy of a selective sigma1 (σ1) receptor agonist, igmesine, in alleviating the observed deficits.Dams received an unpredictable 90-min duration restraint stress from gestational day E17 to E20. Learning was examined in offspring between day P24 and P36 using...

  14. Evaluation of the protective effects of tocotrienol-rich fraction from palm oil on the dentate gyrus following chronic restraint stress in rats

    OpenAIRE

    Saiful Bhari Talip; Mohd Asnizam Asari; Aaijaz Ahmed Khan; Kuttulebbai Nainamohamed Salam Sirajudeen

    2013-01-01

    Exposure to chronic restraint stress has been shown to cause a number of morphological changes in the hippocampal formation of rats. Tocotrienol, an isoform of vitamin E, exhibits numerous health benefits, different from those of tocopherol. Recent studies have demonstrated that tocotrienol prevents stress-induced changes in the gastric mucosa, thus indicating that it may also protect other organs such as the brain from the damaging effects of stress. Therefore, the aim of the present study w...

  15. CENTRAL 5-ALPHA REDUCTION OF TESTOSTERONE IS REQUIRED FOR TESTOSTERONE’S INHIBITION OF THE HYPOTHALAMO-PITUITARY-ADRENAL AXIS RESPONSE TO RESTRAINT STRESS IN ADULT MALE RATS

    Science.gov (United States)

    Handa, Robert J.; Kudwa, Andrea E.; Donner, Nina C.; McGivern, Robert F.; Brown, Roger

    2013-01-01

    In rodents, the hypothalamo-pituitary-adrenal (HPA) axis is controlled by a precise regulatory mechanism that is influenced by circulating gonadal and adrenal hormones. In males, gonadectomy increases the adrenocorticotropic hormone (ACTH) and corticosterone (CORT) response to stressors, and androgen replacement returns the response to that of the intact male. Testosterone (T) actions in regulating HPA activity may be through aromatization to estradiol, or by 5α-reduction to the more potent androgen, dihydrotestosterone (DHT). To determine if the latter pathway is involved, we assessed the function of the HPA axis response to restraint stress following hormone treatments, or after peripheral or central treatment with the 5α-reductase inhibitor, finasteride. Initially, we examined the timecourse whereby gonadectomy alters the CORT response to restraint stress. Enhanced CORT responses were evident within 48hrs following gonadectomy. Correspondingly, treatment of intact male rats with the 5α-reductase inhibitor, finasteride, for 48 hrs, enhanced the CORT and ACTH response to restraint stress. Peripheral injections of gonadectomized male rats with DHT or T for 48 hrs reduced the ACTH and CORT response to restraint stress. The effects of T, but not DHT, could be blocked by the third ventricle administration of finasteride prior to stress application. These data indicate that the actions of T in modulating HPA axis activity involve 5α-reductase within the central nervous system. These results further our understanding of how T acts to modulate the neuroendocrine stress responses and indicate that 5α reduction to DHT is a necessary step for T action. PMID:23880372

  16. Central 5-alpha reduction of testosterone is required for testosterone's inhibition of the hypothalamo-pituitary-adrenal axis response to restraint stress in adult male rats.

    Science.gov (United States)

    Handa, Robert J; Kudwa, Andrea E; Donner, Nina C; McGivern, Robert F; Brown, Roger

    2013-09-01

    In rodents, the hypothalamo-pituitary-adrenal (HPA) axis is controlled by a precise regulatory mechanism that is influenced by circulating gonadal and adrenal hormones. In males, gonadectomy increases the adrenocorticotropic hormone (ACTH) and corticosterone (CORT) response to stressors, and androgen replacement returns the response to that of the intact male. Testosterone (T) actions in regulating HPA activity may be through aromatization to estradiol, or by 5α-reduction to the more potent androgen, dihydrotestosterone (DHT). To determine if the latter pathway is involved, we assessed the function of the HPA axis response to restraint stress following hormone treatments, or after peripheral or central treatment with the 5α-reductase inhibitor, finasteride. Initially, we examined the timecourse whereby gonadectomy alters the CORT response to restraint stress. Enhanced CORT responses were evident within 48 h following gonadectomy. Correspondingly, treatment of intact male rats with the 5α-reductase inhibitor, finasteride, for 48 h, enhanced the CORT and ACTH response to restraint stress. Peripheral injections of gonadectomized male rats with DHT or T for 48 h reduced the ACTH and CORT response to restraint stress. The effects of T, but not DHT, could be blocked by the third ventricle administration of finasteride prior to stress application. These data indicate that the actions of T in modulating HPA axis activity involve 5α-reductase within the central nervous system. These results further our understanding of how T acts to modulate the neuroendocrine stress responses and indicate that 5α reduction to DHT is a necessary step for T action. PMID:23880372

  17. HOW DO THE CHARACTERISTICS OF CONTEXT INFLUENCE THE WORK OF FACILITATORS WHEN IMPLEMENTING A STANDARDISED EDUCATIONAL INTERVENTION TARGETING NURSING HOME STAFF TO REDUCE RESTRAINT IN DEMENTIA CARE?

    OpenAIRE

    2015-01-01

    This research is part of a larger study - a sequential mixed method education intervention targeting staff in 24 Nursing Homes (NHs) in Norway to reduce use of restraint and psychotropic drugs. Building on a previous successful intervention, we used the Promoting Action on Research Implementation in Health Services (PARIHS) prospectively to combine cluster randomized controlled trial, participatory action research (PAR) and ethnography to design and evaluate the effectiveness of 2 day staff e...

  18. Maternal restraint stress delays maturation of cation-chloride cotransporters and GABAA receptor subunits in the hippocampus of rat pups at puberty

    OpenAIRE

    Veerawatananan, Bovorn; Surakul, Pornprom; Chutabhakdikul, Nuanchan

    2015-01-01

    The GABAergic synapse undergoes structural and functional maturation during early brain development. Maternal stress alters GABAergic synapses in the pup's brain that are associated with the pathophysiology of neuropsychiatric disorders in adults; however, the mechanism for this is still unclear. In this study, we examined the effects of maternal restraint stress on the development of Cation-Chloride Cotransporters (CCCs) and the GABAA receptor α1 and α5 subunits in the hippocampus of rat pup...

  19. Combined use of spatial restraint stress and middle cerebral artery occlusion is a novel model of post-stroke depression in mice

    OpenAIRE

    Gaocai Zhang; Li Chen; Lingli Yang; Xiaodong Hua; Beiqun Zhou; Zhigang Miao; Jizhen Li; Hua Hu; Michael Namaka; Jiming Kong; Xingshun Xu

    2015-01-01

    Post stroke depression (PSD) is one of the most common complications of ischemic stroke. At present, the underlying mechanisms are unclear, largely because there are no reliable, valid and reproducible animal models of PSD. Here we report a novel animal model of PSD that displays consistent and reliable clinical features of hemiplegic stroke. The animal model encompasses a combination of the middle cerebral artery occlusion (MCAO) and spatial restraint stress. We found that a 60-minute MCAO f...

  20. Focusing on media body ideal images triggers food intake among restrained eaters: a test of restraint theory and the elaboration likelihood model.

    Science.gov (United States)

    Boyce, Jessica A; Kuijer, Roeline G

    2014-04-01

    Although research consistently shows that images of thin women in the media (media body ideals) affect women negatively (e.g., increased weight dissatisfaction and food intake), this effect is less clear among restrained eaters. The majority of experiments demonstrate that restrained eaters - identified with the Restraint Scale - consume more food than do other participants after viewing media body ideal images; whereas a minority of experiments suggest that such images trigger restrained eaters' dietary restraint. Weight satisfaction and mood results are just as variable. One reason for these inconsistent results might be that different methods of image exposure (e.g., slideshow vs. film) afford varying levels of attention. Therefore, we manipulated attention levels and measured participants' weight satisfaction and food intake. We based our hypotheses on the elaboration likelihood model and on restraint theory. We hypothesised that advertent (i.e., processing the images via central routes of persuasion) and inadvertent (i.e., processing the images via peripheral routes of persuasion) exposure would trigger differing degrees of weight dissatisfaction and dietary disinhibition among restrained eaters (cf. restraint theory). Participants (N = 174) were assigned to one of four conditions: advertent or inadvertent exposure to media or control images. The dependent variables were measured in a supposedly unrelated study. Although restrained eaters' weight satisfaction was not significantly affected by either media exposure condition, advertent (but not inadvertent) media exposure triggered restrained eaters' eating. These results suggest that teaching restrained eaters how to pay less attention to media body ideal images might be an effective strategy in media-literary interventions. PMID:24854816

  1. Administration of exogenous acylated ghrelin or rikkunshito, an endogenous ghrelin enhancer, improves the decrease in postprandial gastric motility in an acute restraint stress mouse model

    OpenAIRE

    Nahata, M; Saegusa, Y.; C. Sadakane; Yamada, C; Nakagawa, K.; Okubo, N.; Ohnishi, S.; Hattori, T.; Sakamoto, N.; Takeda, H.

    2014-01-01

    Background Physical or psychological stress causes functional disorders in the upper gastrointestinal tract. This study aims to elucidate the ameliorating effect of exogenous acylated ghrelin or rikkunshito, a Kampo medicine which acts as a ghrelin enhancer, on gastric dysfunction during acute restraint stress in mice. Methods Fasted and postprandial motor function of the gastric antrum was wirelessly measured using a strain gauge force transducer and solid gastric emptying was detected in mi...

  2. Interpretation to Restraint Standards of Joanna Briggs Institute%澳大利亚循证卫生保健中心身体约束标准介绍

    Institute of Scientific and Technical Information of China (English)

    成守珍; 高明榕; 王若婧

    2014-01-01

    The authors summarized the Restraint Standards of Joanna Briggs Institute, and introduced the deifnition of physical restraint, the responsibilities of nurses, the principles and management of implementing physical restraint, the reason of physical restraint, measures to reduce physical restraint, and patient management of aged patients, to provide references for physical restraint in our country.%本文对2013年7月澳大利亚循证卫生保健中心(JBI)在其网站公布的身体约束标准中对身体约束的定义、护士的责任、实施身体约束的原则及管理、身体约束的原因、减少身体约束的措施及对老年人的约束7个方面进行了介绍,以期为我国身体约束的使用提供参考。

  3. A New Mechanism of Vitamin C Effects on A/FM/1/47(H1N1 Virus-Induced Pneumonia in Restraint-Stressed Mice

    Directory of Open Access Journals (Sweden)

    Ying Cai

    2015-01-01

    Full Text Available It is well known that vitamin C could protect against influenza infection, but little is known about the mechanisms. This study aimed to investigate the influence and possible mechanisms of vitamin C on pneumonia induced by influenza virus in stressed mice. Results showed that restraint stress significantly increased the mortality and the severity of pneumonia in mice caused by A/FM/1/47(H1N1 virus infection, which was attenuated by oral administration of vitamin C (125 and 250 mg/kg. Moreover, vitamin C administration significantly decreased expression of susceptibility genes, including mitochondrial antiviral signaling (MAVS and interferon regulatory factor 3 (IRF3, and increased expression of NF-κB. These work in conjunction to induce type I interferons (IFNs and elicit innate antiviral response as key factors in RIG-I-mediated signal transduction pathway. The above effects of vitamin C were further found to relate with inhibition of excess CORT synthesis by regulating steroid hydroxylating enzymes in adrenal gland. In conclusion, the protective effects of vitamin C on influenza virus-caused pneumonia might be related to its inhibition of CORT synthesis, which reduces the susceptibility to influenza viral infection in restraint-stressed mice. These findings provide a new mechanism for the effects of vitamin C on influenza virus-induced pneumonia in restraint-stressed mice.

  4. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.

    Science.gov (United States)

    Nagata, Kazufumi; Nakashima-Kamimura, Naomi; Mikami, Toshio; Ohsawa, Ikuroh; Ohta, Shigeo

    2009-01-01

    We have reported that hydrogen (H(2)) acts as an efficient antioxidant by gaseous rapid diffusion. When water saturated with hydrogen (hydrogen water) was placed into the stomach of a rat, hydrogen was detected at several microM level in blood. Because hydrogen gas is unsuitable for continuous consumption, we investigated using mice whether drinking hydrogen water ad libitum, instead of inhaling hydrogen gas, prevents cognitive impairment by reducing oxidative stress. Chronic physical restraint stress to mice enhanced levels of oxidative stress markers, malondialdehyde and 4-hydroxy-2-nonenal, in the brain, and impaired learning and memory, as judged by three different methods: passive avoidance learning, object recognition task, and the Morris water maze. Consumption of hydrogen water ad libitum throughout the whole period suppressed the increase in the oxidative stress markers and prevented cognitive impairment, as judged by all three methods, whereas hydrogen water did not improve cognitive ability when no stress was provided. Neural proliferation in the dentate gyrus of the hippocampus was suppressed by restraint stress, as observed by 5-bromo-2'-deoxyuridine incorporation and Ki-67 immunostaining, proliferation markers. The consumption of hydrogen water ameliorated the reduced proliferation although the mechanistic link between the hydrogen-dependent changes in neurogenesis and cognitive impairments remains unclear. Thus, continuous consumption of hydrogen water reduces oxidative stress in the brain, and prevents the stress-induced decline in learning and memory caused by chronic physical restraint. Hydrogen water may be applicable for preventive use in cognitive or other neuronal disorders. PMID:18563058

  5. Impact of eLearning course on nurses' professional competence in seclusion and restraint practices: 9-month follow-up results of a randomized controlled study (ISRCTN32869544).

    Science.gov (United States)

    Kontio, R; Hätönen, H; Joffe, G; Pitkänen, A; Lahti, M; Välimäki, M

    2013-04-01

    eLearning may facilitate continuing vocational education, but data on the long-term effects of an eLearning course are lacking. The aim of this study was to explore the long-term impact of an eLearning course entitled ePsychNurse.Net on psychiatric nurses' professional competence in practicing seclusion and restraint and on their job satisfaction and general self-efficacy at 9-month follow-up. In a randomized controlled study, 12 wards were randomly assigned to the ePsychNurse.Net (intervention) or training as usual (control). Baseline and 9-month follow-up data on nurses' knowledge of coercion-related legislation, physical restraint and seclusion, their attitudes towards physical restraint and seclusion, job satisfaction and general self-efficacy were analysed for 137 completers (those who participated in the 9-month follow-up assessment). No between-group differences were found on any variable, with the exception of a change in attitude to seclusion in favour of the control group. The findings of the long-term effects did not differ from the immediate outcomes (3-month follow-up) and the improved level of knowledge acquired and further consolidation of that knowledge did not take place in the 6-month period after the 3-month ePsychNurse.Net course. The ePsychNurse.Net should be further developed and its future modifications will require additional studies, probably with some new outcome measures. PMID:22672441

  6. The effect of chronic peripheral nesfatin-1 application on blood pressure in normal and chronic restraint stressed rats: related with circulating level of blood pressure regulators.

    Science.gov (United States)

    Ayada, Ceylan; Turgut, Günfer; Turgut, Sebahat; Güçlü, Zuhal

    2015-01-01

    Nesfatin is a peptide secreted by peripheral tissues, central and peripheral nervous system. It is involved in the regulation of homeostasis. Although the effects of nesfatin-1 on nutrition have been studied widely in the literature, the mechanisms of nesfatin-1 action and also relations with other physiological parameters are still not clarified well. We aimed to investigate the effect of peripheral chronic nesfatin-1 application on blood pressure regulation in normal and in rats exposed to restraint immobilization stress. In our study, three month-old male Wistar rats were used. Rats were divided into 4 groups as Control, Stress, Control+Nesfatin-1, Nesfatin-1+Stress. Angiotensinogen, angiotensin converting enzyme 2, angiotensin II, endothelin-1, endothelial nitric oxide synthase, aldosterone, cortisol, nesfatin-1 levels were determined in plasma samples by ELISA. Our results have shown that chronic peripheral nesfatin-1 administration increases blood pressure in normal and in rats exposed to chronic restraint stress. Effect of nesfatin-1 on circulating level of angiotensinogen, angiotensin converting enzyme 2, angiotensin II, endothelin-1, endothelial nitric oxide synthase, aldosterone and cortisol has been identified. We can conclude that elevated high blood pressure after chronic peripheral nesfatin-1 administration in rats exposed to chronic restraint stress may be related to decreased plasma level of endothelial nitric oxide synthase concentration. PMID:25504061

  7. Description of the type of chemical restraint used by French veterinarians to perform hip dysplasia screening radiographs. A retrospective study based on 3302 radiographs.

    Science.gov (United States)

    Maitre, P; Genevois, J-P; Remy, D; Carozzo, C; Arnault, F; Buttin, P; Viguier, E; Fau, D

    2010-01-01

    The objective of this study was to investigate the type of chemical restraint used by French practitioners to perform official hip screening radiographs, to determine the proportion of dogs under general anesthesia versus dogs under sedation, and to search for a difference in hip dysplasia (HD) prevalence between the two groups. From September 2005 to August 2008, 3302 conventional ventrodorsal hip extended radiographs sent for official scoring to the same panellist were selected because information related to the type of chemical restraint had been provided. There were 2825 dogs under general anesthesia and 477 were sedated. Chemical restraint used by French veterinarians to perform HD screening radiographs is mainly based on general intra-venous anesthesia with an alpha2 agonist associated with ketamine. A single injection of alpha2 agonist is also mostly used for dogs which are radiographed while under sedation. A very low (1.7%) difference in HD prevalence was noted between the anesthetized and the sedated group. Except for acepromazine, which has been demonstrated to provide insufficient muscle relaxation to show evidence of hip laxity, the protocols seem acceptable as regards the Federation Cynologique Internationale requirements for HD screening. PMID:20585709

  8. Systolic blood pressure and heart rate in cats with chronic kidney disease undergoing chemical restraint during hemodialysis

    Directory of Open Access Journals (Sweden)

    Karine Kleine Figueiredo dos Santos

    2016-04-01

    Full Text Available Dialysis is one of the used methods for treatment of Acute Renal Injury (ARI and Chronic Kidney Disease (CKD to replace the function of the kidneys when refers to blood depuration. Hemodialysis removes toxins accumulated in the body directly from the blood, being a useful alternative therapy for dogs and cats with CKD in advanced stages. Because of the difficulty on handling the patient feline, this procedure requires sedation. However, few studies have been conducted to assess the safety of anesthesia in dogs and cats with CKD undergoing dialysis. The present study aimed to evaluate two different protocols of chemical restraint in cats with CKD and the effect of these on systolic blood pressure (SBP and heart rate (HR, since the procedure of extracorporeal circulation leads the patient to a hypotensive frame. Twelve adult cats were used, with an average weight of 4 kg, CKD, underwent two anesthetic protocols: Group GP (n = 6 using propofol, and group GCM (n = 6 using ketamine-midazolam association for the implantation procedure of central venous catheter (CVC and hemodialysis. Cats in GP as well as the GCM group showed statistical difference in the change in SBP and HR only from baseline compared to the other time points evaluated. The two protocols maintained SBP and HR within physiological values.

  9. Attenuation of acute and chronic restraint stress-induced perturbations in experimental animals by Zingiber officinale Roscoe.

    Science.gov (United States)

    Lakshmi, B V S; Sudhakar, M

    2010-02-01

    Ethanolic extract of rhizomes of Zingiber officinale was investigated on anoxia stress tolerance test in Swiss mice. The animals were also subjected to acute physical stress (swimming endurance test) to gauge the anti-stress potential of the extract. Further to evaluate the anti-stress activity of Z. officinale in chronic stress condition, fresh Wistar rats were subjected to cold restraint stress (4 degrees for 2 h) for 10 days. Stimulation of hypothalamus pituitary adrenal axis in stressful condition alters plasma glucose, triglyceride, cholesterol, BUN and corticosterone levels. There is also alteration in the blood cell counts. Pretreatment with the extract significantly ameliorated the stress-induced variations in these biochemical levels and blood cell counts in both acute and chronic stress models. The extract treated animals showed increase in swimming endurance time and increase in anoxia tolerance time in physical and anoxia stress models, respectively. Treatment groups also reverted back increase in liver, adrenal gland weights and atrophy of spleen caused by cold chronic stress and swimming endurance stress models. The results indicate that ethanolic extract of Z. officinale has significant adaptogenic activity against a variety of biochemical and physiological perturbations in different stress models. PMID:19909780

  10. Physical restraint for psychiatric patients and its associations with clinical characteristics and the National Mental Health Law in China.

    Science.gov (United States)

    An, Feng-Rong; Sha, Sha; Zhang, Qing-E; Ungvari, Gabor S; Ng, Chee H; Chiu, Helen F K; Wu, Ping-Ping; Jin, Xin; Zhou, Jian-Song; Tang, Yi-Lang; Xiang, Yu-Tao

    2016-07-30

    Physical restraint (PR) for patients is an ongoing controversial topic in psychiatry. This study examined the percentage of PR and its associations with clinical characteristics and the implementation of the National Mental Health Law (NMHL) in China. The study consecutively assessed a sample of 1364 psychiatric inpatients. Socio-demographic and clinical data including use of PR were collected from the medical records using a form designed for this study and confirmed via interview. Psychopathology and insight were measured using standardized instruments. The percentage of PR was 27.2% in the whole sample with 30.7% and 22.4% occurring respectively before and after the NMHL implementation (p=0.001). In multiple logistic regression analysis PR was positively associated with unemployment, lower income, aggression in the past month, being admitted before the NMHL implementation and poorer insight. The percentage of PR in Chinese psychiatric patients is associated with various clinical factors and appeared to decrease after the implementation of the NMHL. Focused and individualized care for patients who are unemployed, have low income, recent aggression and poor insight would be necessary at early stages of admission. PMID:27179180

  11. Absorptive capacity and smart companies

    Directory of Open Access Journals (Sweden)

    Patricia Moro González

    2014-12-01

    Full Text Available Purpose: The current competitive environment is substantially modifying the organizations’ learning processes due to a global increase of available information allowing this to be transformed into knowledge. This opportunity has been exploited since the nineties by the tools of “Business Analytics” and “Business Intelligence” but, nevertheless, being integrated in the study of new organizational capacities engaged in the process of creating intelligence inside organizations is still an outstanding task. The review of the concept of absorptive capacity and a detailed study from the perspective of this new reality will be the main objective of study of this paper.Design/methodology/approach: By comparing classical absorptive capacity and absorptive capacity from the point of view of information management tools in each one of the three stages of the organizational learning cycle, some gaps of the former are overcome/fulfilled. The academic/bibliographical references provided in this paper have been obtained from ISI web of knowledge, Scopus and Dialnet data bases, supporting the state of affairs on absorptive capacity and thereafter filtering by "Business Intelligence" and "Business Analytics". Specialized websites and Business Schools` Publications there have also been included, crowning the content on information management tools used that are currently used in the strategic consulting.Findings: Our contribution to the literature is the development of "smart absorptive capacity". This is a new capacity emerging from the reformulation of the classical concept of absorptive capacity wherein some aspects of its definition that might have been omitted are emphasized. The result of this new approach is the creation of a new Theoretical Model of Organizational Intelligence, which aims to explain, within the framework of the Resources and Capabilities Theory, the competitive advantage achieved by the so-called smart companies

  12. Capacity sharing of water reservoirs

    Science.gov (United States)

    Dudley, Norman J.; Musgrave, Warren F.

    1988-05-01

    The concept of a water use property right is developed which does not apply to water volumes as such but to a share of the capacity (not contents) of river storage reservoirs and their inflows. The shareholders can withdraw water from their share over time in accordance with their preferences for stability of water deliveries. The reservoir authority does not manage reservoir releases but keeps record of individual shareholder's withdrawals and net inflows to monitor the quantity of water in each shareholder's capacity share. A surplus of total reservoir contents over the sum of the contents of the individual shareholder's capacity shares will accrue over time. Two different criteria for its periodic distribution among shareholders are compared. A previous paper Dudley (this issue(b)) noted a loss of short-run economic efficiency as reservoir and farm management decision making become separated. This is largely overcome by capacity sharing which allows each user to integrate the management of their portion of the reservoir and their farming operations. The nonattenuated nature of the capacity sharing water rights also promotes long-run economic efficiency.

  13. On risk and decisional capacity.

    Science.gov (United States)

    Checkland, D

    2001-02-01

    Limits to paternalism are, in the liberal democracies, partially defined by the concepts of decision-making capacity/incapacity (mental competence/incompetence). The paper is a response to Ian Wilks's (1997) recent attempt to defend the idea that the standards for decisional capacity ought to vary with the degree of risk incurred by certain choices. Wilks's defense is based on a direct appeal to the logical features of examples and analogies, thus attempting to by-pass earlier criticisms (e.g., Culver & Gert, 1990) of risk-based standards. Wilks's argument is found wanting on the grounds that he misconstrues the logic of such capacity, especially in accounting for conceptual and pragmatic ties with issues of decisional authority. A diagnosis is offered as to the source of Wilks's error (the assumption that mental competence is a species of wider genus of "competence"), and an alternative way of accounting for risk within the predominant contemporary legal framework is sketched. PMID:11262640

  14. Improving African health research capacity

    DEFF Research Database (Denmark)

    Lazarus, Jeff; Wallace, Samantha A; Liljestrand, Jerker

    2010-01-01

    is the migration of health professionals to countries that offer more lucrative opportunities, like those in western Europe. To combat this ''brain drain'', already back in 1984, the Swedish International Development Cooperation Agency (Sida) created a training programme in which healthcare professionals from......The issue of strengthening local research capacity in Africa is again high on the health and development agenda. The latest initiative comes from the Wellcome Trust. But when it comes to capacity development, one of the chief obstacles that health sectors in the region must confront...... of beneficial research capacity in the countries of sub-Saharan Africa, this article suggests several recommendations to both donors and governments that have broad application for general health research issues in the region....

  15. The Innovative Capacity of Firms

    Directory of Open Access Journals (Sweden)

    Neely Andy

    2014-11-01

    Full Text Available Innovation is widely accepted as a crucial competitive weapon in today's global market place. Yet the levels of innovation achieved by different firms, even within the same industry, can vary widely. The key question raised by this observation is why. Why are some firms more innovative than others? What are the factors that determine a firm's capacity to innovate and how can these be managed to enhance the firm's innovative potential? This paper sets out to address these and related issues. It reports the results of a study of competitiveness and innovation of firms in the East of England. In the paper it is argued that the innovative capacity of a firm is a function of the firm's culture, resources, competences and networks. Justification for this framework is provided by a review of the relevant literature and a series of case studies examining the capacity to innovate of a sample of firms in the East of England.

  16. Antioxidant capacity of eugenol derivatives

    Directory of Open Access Journals (Sweden)

    María E. Hidalgo

    2009-01-01

    Full Text Available Toxicity and antioxidant capacity of eugenol derivatives (E2 = 2-Methoxy-4-[1-propenylphenyl]acetate, E3 = 4-Allyl-2-methoxyphenylacetate, E4 = 4-Allyl-2-methoxy-4-nitrophenol, E5 = 5-Allyl-3-nitrobenzene-1,2-diol, E6 = 4-Allyl-2-methoxy-5-nitrophenyl acetate were evaluated in order to determine the influence of the sustituents. E2-E6 were synthesized from eugenol (E1. E1 was extracted from cloves oil, and E2-E6 were obtained through acetylation and nitration reactions. Antioxidant capacity evaluated by DPPH (1, 1-Diphenyl-2-picrylhydrazil and ORAC fluorescein demonstrated that E1 and E5 have a higher capacity and the minor toxicity evaluated by red blood cells haemolysis and the Artemia saline test. In accordance with our results, the compound's (E1-E5 use in the pharmaceutical, cosmetic and or food industries could be suggested.

  17. Livelihood Resilience and Adaptive Capacity

    DEFF Research Database (Denmark)

    Thulstrup, Andreas Waaben

    2015-01-01

    This article analyses the implementation and outcomes of national development programs in a mountainous commune in Vietnam. The article traces the history of State intervention and the capacity of households and the community to adapt to change. The assessment reveals unintended consequences...... of the programs which strongly influence the ability of households to adapt to change. Some households possess more adaptive capacity given their better access to capital while others remain vulnerable because they are constrained in accessing resources and engage in nondiversified livelihoods. If shock events...

  18. THE LEGAL CAPACITY TO TRADE

    OpenAIRE

    ADELIN UNGUREANU

    2014-01-01

    Trading is a part of our society. The man has been trading from ancient times so the amount of trades and transactions around the world is huge. In order for us to initiate, organize and deploy such trades we have to have certain rules which can help regulate the social and professional or legal aspect of trades. Therefore the sole trader capacity must be obtained and used in order for the contracts to be valid. The right and obligations that come with this capacity constitute activities t...

  19. THE LEGAL CAPACITY TO TRADE

    Directory of Open Access Journals (Sweden)

    ADELIN UNGUREANU

    2014-12-01

    Full Text Available Trading is a part of our society. The man has been trading from ancient times so the amount of trades and transactions around the world is huge. In order for us to initiate, organize and deploy such trades we have to have certain rules which can help regulate the social and professional or legal aspect of trades. Therefore the sole trader capacity must be obtained and used in order for the contracts to be valid. The right and obligations that come with this capacity constitute activities that can be reflected and analysed by obtaining and maintain the sole trader status.

  20. Localization capacity of human listeners

    DEFF Research Database (Denmark)

    Hammershøi, Dorte

    2009-01-01

    For some scenarios and situations, successful localization of the sound is vital for the hearing experience. One aspect of this is the natural limits of the human localization capacity, incl. dependence on e.g. direction and distance. When addressed in laboratory experiments, the significance of ...

  1. Frequency-dependent heat capacity

    DEFF Research Database (Denmark)

    Behrens, Claus Flensted

    The frequency–dependent heat capacity of super-cooled glycerol near the glass transition is measured using the 3w detection technique. An electrical conducting thin film with a temperature–dependent electrical resistance is deposited on a substrate. The thin film is used simultaneously as a heater...

  2. Capacity Building in Local Government

    Directory of Open Access Journals (Sweden)

    Rochyati Wahyuni Triana

    2013-02-01

    Full Text Available The aim of this research is to examine the concept of local government capacity building in both theoretical and operational aspects, regarding especially with local authorities in Indonesia, after the enforcement of regional autonomy. This is a basic research (fundamental research of library research type. Data collection technique involves using data sourced from a variety of secondary sources, as it should be; books, journals, and related legislation. To draw a conclusion regarding with the building of regional capacity after the implementation of regional autonomy, the data are analyzed using descriptive analysis technique; that is, examining secondary data based on Indonesian condition. This research concludes that Capacity Building is a huge job for the an autonomous local government, particularly when dealing with the system which is deemed to prioritize self-serving rather than public serving; yet this capacity building mission deserves to fight for. Stakeholders (other than legislatives need to regularly monitor the improved performance of the government so that the high expectation of the society could be fulfilled through the enforcement of regional autonomy.

  3. The COSPAR Capacity Building Initiative

    NARCIS (Netherlands)

    Gabriel, C.; Willmore, P.; Méndez, M.; Mathieu, P.-P.; Santolik, O.; Smith, R.; Evans, Ian N.; Accomazzi, Alberto; Mink, Douglas J.; Rots, Arnold H.

    2011-01-01

    The COSPAR Capacity Building Workshops have been conceived to meet the following objectives: (1) To increase knowledge and use of public archives of space data in order both to broaden the scope of research programs in developing countries and to ensure that scientists in those countries are aware o

  4. Palm vitamin E reduces catecholamines, xanthine oxidase activity and gastric lesions in rats exposed to water-immersion restraint stress

    Directory of Open Access Journals (Sweden)

    Mohd Fahami Nur Azlina

    2012-05-01

    Full Text Available Abstract Background This study examined the effects of Palm vitamin E (PVE and α-tocopherol (α-TF supplementations on adrenalin, noradrenalin, xanthine oxidase plus dehydrogenase (XO + XD activities and gastric lesions in rats exposed to water-immersion restraint stress (WIRS. Methods Sixty male Sprague–Dawley rats (200-250 g were randomly divided into three equal sized groups. The control group was given a normal diet, while the treated groups received the same diet with oral supplementation of PVE or α-TF at 60 mg/kg body weight. After the treatment period of 28 days, each group was further subdivided into two groups with 10 rats without exposing them to stress and the other 10 rats were subjected to WIRS for 3.5 hours. Blood samples were taken to measure the adrenalin and noradrenalin levels. The rats were then sacrificed following which the stomach was excised and opened along the greater curvature and examined for lesions and XO + XD activities. Results The rats exposed to WIRS had lesions in their stomach mucosa. Our findings showed that dietary supplementations of PVE and α-TF were able to reduce gastric lesions significantly in comparison to the stressed control group. WIRS increased plasma adrenalin and noradrenalin significantly. PVE and α-TF treatments reduced these parameters significantly compared to the stressed control. Conclusions Supplementations with either PVE or α-TF reduce the formation of gastric lesions. Their protective effect was related to their abilities to inhibit stress induced elevation of adrenalin and noradrenalin levels as well as through reduction in xanthine oxidase and dehydrogenase activities.

  5. Price abuse monitoring under paragraph 29 of the Law Against Restraints on Competition; Die Preismissbrauchskontrolle nach paragraph 29 GWB

    Energy Technology Data Exchange (ETDEWEB)

    Koleva, Raliza

    2013-08-01

    Written against the backdrop of criticism levelled at paragraph 29 of the Law Against Restraints on Competition (GWB) the present study undertakes a critical discussion of this legal norm along with questions and points of criticism that have been raised in its context in the literature and case law. It first addresses the central question as to whether paragraph 29 GWB conforms to the stipulations of European law and the German constitution. It then expounds the system behind paragraph 29 GWB, making a detailed examination of the individual elements of the offences covered by the regulation while giving thorough consideration to existing case law on instruments of price abuse monitoring that have been used to date under cartel law. A further focus of the present study is on the question as to what circumstances a supply company under suspicion of price abuse may claim in attempting to justify significant differences that have been found to exist between its own prices and those of a comparable company. This aspect is of great practical relevance in lawsuits concerning price abuse under cartel law, since the option of demonstrating justification is the most important line of approach for supply companies under suspicion of price abuse in attempting to fend off such allegations. Based on an analysis of past practice of the German Federal Cartel Office and the antitrust courts the author undertakes to determine a scale for assessing the costs which the responding supply company can claim in its defence. Finally she endeavours to methodologically capture the price limit concept, making proposals for its practical application with due consideration to the findings that have transpired from the study.

  6. Endoplasmic reticulum stress is involved in restraint stress-induced hippocampal apoptosis and cognitive impairments in rats.

    Science.gov (United States)

    Zhang, Yue; Liu, Wei; Zhou, Yi; Ma, Chunling; Li, Shujin; Cong, Bin

    2014-05-28

    Long-term exposure to stressful stimuli can reduce hippocampal volume and cause cognitive impairments, but the underlying mechanisms are not well understood. Endoplasmic reticulum stress (ERS) is considered an early or initial response of cells under stress and linked to neuronal death in various neurodegenerative diseases. The present study investigated the involvement of ERS in restraint stress (RS)-induced hippocampal apoptosis and cognitive impairments. Using the rat RS model for 21 consecutive days, we found that the hippocampal apoptotic rate was significantly up-regulated as compared with unstressed controls, and salubrinal (ERS inhibitor) pretreatment effectively reduced the increase. As the marker of ERS, the 78-kDa glucose-regulated protein (GRP78) and the target molecule of the unfolded protein response (UPR), the splice variant of X-box binding protein 1 (sXBP-1) were also markedly increased in RS rats. Furthermore, in the three possible signaling pathways of ERS-induced apoptosis, the protein and mRNA levels of C/EBP homologous protein (CHOP) were significantly up-regulated, and caspase-12 was activated and cleaved, which suggested that these two pathways crucially contributed to hippocampal cell death. However, we found no changes in protein levels of phosphorylated JNK, implying that the JNK pathway was not the primary pathway involved in hippocampal apoptosis. It is more important that the cognitive impairments caused by RS were also effectively alleviated by salubrinal pretreatment. The present results suggested that ERS in hippocampus was excessively activated under stress, and amelioration of ERS could be a novel strategy to prevent and treat impaired cognitive function induced by RS. PMID:24732417

  7. The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress.

    Science.gov (United States)

    Zhao, X; Seese, R R; Yun, K; Peng, T; Wang, Z

    2013-08-29

    There is high comorbidity between stress-related psychiatric disorders and addiction, suggesting they may share one or more common neurobiological mechanisms. Because of its role in both depressive and addictive behaviors, the galanin system is a strong candidate for such a mechanism. In this study, we tested if galanin and its receptors are involved in stress-associated behaviors and drug addiction. Mice were exposed to 21 days of chronic restraint stress (CRS); subsequently, mRNA levels of galanin, galanin receptors (GalRs), the rate-limiting enzymes for the synthesis of monoamines, and monoamine autoreceptors were measured in the nucleus accumbens by a quantitative real-time polymerase chain reaction. Moreover, we tested the effects of this stress on morphine-induced addictive behaviors. We found that CRS induced anxiety and depression-like behaviors, impaired the formation and facilitated the extinction process in morphine-induced conditioned place preference (CPP), and also blocked morphine-induced behavioral sensitization. These behavioral results were accompanied by a CRS-dependent increase in the mRNA expression of galanin, GalR1, tyrosine hydroxylase (TH), tryptophan hydroxylase 2, and 5-HT1B receptor. Interestingly, treatment with a commonly used antidepressant, fluoxetine, normalized the CRS-induced behavioral changes based on reversing the higher expression of galanin and TH while increasing the expression of GalR2 and α2A-adrenceptor. These results indicate that activating the galanin system, with corresponding changes to noradrenergic systems, following chronic stress may modulate stress-associated behaviors and opiate addiction. Our findings suggest that galanin and GalRs are worthy of further exploration as potential therapeutic targets to treat stress-related disorders and drug addiction.

  8. The identification of metabolic disturbances in the prefrontal cortex of the chronic restraint stress rat model of depression.

    Science.gov (United States)

    Liu, Lanxiang; Zhou, Xinyu; Zhang, Yuqing; Liu, Yiyun; Yang, Lining; Pu, Juncai; Zhu, Dan; Zhou, Chanjuan; Xie, Peng

    2016-05-15

    Major depressive disorder, with serious impairment in cognitive and social functioning, is a complex psychiatric disorder characterized by pervasive and persistent low mood and a loss of interest or pleasure. However, the underlying molecular mechanisms of depression remain largely unknown. In this study, we used a non-targeted metabolomics approach based on gas chromatography-mass spectrometry of the prefrontal cortex in chronic restraint stress (CRS)-treated rats. CRS was induced in the stress group by restraining rats in a plastic restrainer for 6h every day. This stress paradigm continued for 21 days. Body weight measurement and behavior tests were applied, including the sucrose preference test for anhedonia, the forced swimming test for despair-like behavior, and open field test and the elevated plus-maze to test for anxiety-like behaviors in rats after CRS. Differentially expressed metabolites associated with CRS-treated rats were identified by combining multivariate and univariate statistical analysis and corrected for multiple testing using the Benjamini-Hochberg procedure. A heat map of differential metabolites was constructed using Matlab. Ingenuity Pathways Analysis was applied to identify the predicted pathways and biological functions relevant to the bio-molecules of interest. Our findings showed that CRS induces depression-like behaviors and not anxiety-like behaviors. Thirty-six metabolites were identified as potential depression biomarkers involved in amino acid metabolism, energy metabolism and lipid metabolism, as well as a disturbance in neurotransmitters. Consequently, this study provides useful insights into the molecular mechanisms of depression. PMID:26947756

  9. Remarks on entanglement assisted classical capacity

    OpenAIRE

    Fan, Heng

    2003-01-01

    The property of the optimal signal ensembles of entanglement assisted channel capacity is studied. A relationship between entanglement assisted channel capacity and one-shot capacity of unassisted channel is obtained. The data processing inequalities, convexity and additivity of the entanglement assisted channel capacity are reformulated by simple methods.

  10. Remarks on entanglement assisted classical capacity

    International Nuclear Information System (INIS)

    The property of the optimal signal ensembles of entanglement assisted channel capacity is studied. A relationship between entanglement assisted channel capacity and one-shot capacity of unassisted channel is obtained. The data processing inequalities, convexity and additivity of the entanglement assisted channel capacity are reformulated by simple methods

  11. Remarks on entanglement assisted classical capacity

    Science.gov (United States)

    Fan, Heng

    2003-06-01

    The property of the optimal signal ensembles of entanglement assisted channel capacity is studied. A relationship between entanglement assisted channel capacity and one-shot capacity of unassisted channel is obtained. The data processing inequalities, convexity and additivity of the entanglement assisted channel capacity are reformulated by simple methods.

  12. Remarks on entanglement assisted classical capacity

    CERN Document Server

    Fan, H

    2003-01-01

    The property of the optimal signal ensembles of entanglement assisted channel capacity is studied. A relationship between entanglement assisted channel capacity and capacities of unassisted and enviornment channels is obtained. The data processing inequalities, convexity and additivity of the entanglement assisted channel capacity are reformulated by simple methods.

  13. High capacity carbon dioxide sorbent

    Energy Technology Data Exchange (ETDEWEB)

    Dietz, Steven Dean; Alptekin, Gokhan; Jayaraman, Ambalavanan

    2015-09-01

    The present invention provides a sorbent for the removal of carbon dioxide from gas streams, comprising: a CO.sub.2 capacity of at least 9 weight percent when measured at 22.degree. C. and 1 atmosphere; an H.sub.2O capacity of at most 15 weight percent when measured at 25.degree. C. and 1 atmosphere; and an isosteric heat of adsorption of from 5 to 8.5 kilocalories per mole of CO.sub.2. The invention also provides a carbon sorbent in a powder, a granular or a pellet form for the removal of carbon dioxide from gas streams, comprising: a carbon content of at least 90 weight percent; a nitrogen content of at least 1 weight percent; an oxygen content of at most 3 weight percent; a BET surface area from 50 to 2600 m.sup.2/g; and a DFT micropore volume from 0.04 to 0.8 cc/g.

  14. Optical information capacity of silicon

    CERN Document Server

    Dimitropoulos, Dimitris

    2014-01-01

    Modern computing and data storage systems increasingly rely on parallel architectures where processing and storage load is distributed within a cluster of nodes. The necessity for high-bandwidth data links has made optical communication a critical constituent of modern information systems and silicon the leading platform for creating the necessary optical components. While silicon is arguably the most extensively studied material in history, one of its most important attributes, an analysis of its capacity to carry optical information, has not been reported. The calculation of the information capacity of silicon is complicated by nonlinear losses, phenomena that emerge in optical nanowires as a result of the concentration of optical power in a small geometry. Nonlinear losses are absent in silica glass optical fiber and other common communication channels. While nonlinear loss in silicon is well known, noise and fluctuations that arise from it have never been considered. Here we report sources of fluctuations...

  15. The carryng capacity of ecosystem

    OpenAIRE

    Del Monte Luna, Pablo; Brooks, Barry W.; Zetina Rejón, Manuel Jesús; Cruz Escalona, Víctor Hugo

    2004-01-01

    We analyse the concept of carrying capacity (CC), from populations to the biosphere, and offer a definition suitable for any level. For communities and ecosystems, the CC evokes density-dependence assumptions analogous to those of population dynamics. At the biosphere level, human CC is uncertain and dynamic, leading to apprehensive rather than practical conclusions. The term CC is widely used among ecological disciplines but remains vague and elusive. We propose the following definition: the...

  16. Dyck's surfaces, systoles, and capacities

    CERN Document Server

    Katz, Mikhail G

    2012-01-01

    We prove an optimal systolic inequality for nonpositively curved Dyck's surfaces. The extremal surface is flat with eight conical singularities, six of angle theta and two of angle 9?pi - theta, for a suitable theta with cos(theta) Q(sqrt{19}). Relying on capacity estimates, we also show that the extremal surface is not conformally equivalent to the hyperbolic surface with maximal systole, yielding a first example of systolic extremality with this behavior.

  17. Qualitative Capacities as Imprecise Possibilities.

    OpenAIRE

    Dubois, Didier; Prade, Henri; Rico, Agnés

    2013-01-01

    National audience This paper studies the structure of qualitative capacities, that is, monotonic set-functions, when they range on a finite totally ordered scale equipped with an order-reversing map. These set-functions correspond to general representations of uncertainty, as well as importance levels of groups of criteria in multicriteria decision-making. More specifically, we investigate the question whether these qualitative set-functions can be viewed as classes of simpler set-function...

  18. Outage capacity of multicarrier systems

    KAUST Repository

    Yilmaz, Ferkan

    2010-01-01

    The probability density function and the cumulative distribution function of the product of shifted Gamma variates are obtained in terms of the generalized Fox\\'s H function. Using these new results, the exact outage capacity of multi carrier transmission through a slow Nakagami-m fading channel is presented. Moreover, it is shown that analytical and simulation results are in perfect agreement. © 2009 IEEE.

  19. Structure determination of uniformly {sup 13}C, {sup 15}N labeled protein using qualitative distance restraints from MAS solid-state {sup 13}C-NMR observed paramagnetic relaxation enhancement

    Energy Technology Data Exchange (ETDEWEB)

    Tamaki, Hajime [Hokkaido University, Graduate School of Life Science (Japan); Egawa, Ayako [Osaka University, Institute for Protein Research (Japan); Kido, Kouki [Hokkaido University, Graduate School of Life Science (Japan); Kameda, Tomoshi [National Institute of Advanced Industrial Science and Technology, Biotechnology Research Institute for Drug Discovery (Japan); Kamiya, Masakatsu; Kikukawa, Takashi; Aizawa, Tomoyasu [Hokkaido University, Faculty of Advanced Life Science (Japan); Fujiwara, Toshimichi [Osaka University, Institute for Protein Research (Japan); Demura, Makoto, E-mail: demura@sci.hokudai.ac.jp [Hokkaido University, Faculty of Advanced Life Science (Japan)

    2016-01-15

    Magic angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) is a powerful method for structure determination of insoluble biomolecules. However, structure determination by MAS solid-state NMR remains challenging because it is difficult to obtain a sufficient amount of distance restraints owing to spectral complexity. Collection of distance restraints from paramagnetic relaxation enhancement (PRE) is a promising approach to alleviate this barrier. However, the precision of distance restraints provided by PRE is limited in solid-state NMR because of incomplete averaged interactions and intermolecular PREs. In this report, the backbone structure of the B1 domain of streptococcal protein G (GB1) has been successfully determined by combining the CS-Rosetta protocol and qualitative PRE restraints. The derived structure has a Cα RMSD of 1.49 Å relative to the X-ray structure. It is noteworthy that our protocol can determine the correct structure from only three cysteine-EDTA-Mn{sup 2+} mutants because this number of PRE sites is insufficient when using a conventional structure calculation method based on restrained molecular dynamics and simulated annealing. This study shows that qualitative PRE restraints can be employed effectively for protein structure determination from a limited conformational sampling space using a protein fragment library.

  20. Health reform requires policy capacity.

    Science.gov (United States)

    Forest, Pierre-Gerlier; Denis, Jean-Louis; Brown, Lawrence D; Helms, David

    2015-05-01

    Among the many reasons that may limit the adoption of promising reform ideas, policy capacity is the least recognized. The concept itself is not widely understood. Although policy capacity is concerned with the gathering of information and the formulation of options for public action in the initial phases of policy consultation and development, it also touches on all stages of the policy process, from the strategic identification of a problem to the actual development of the policy, its formal adoption, its implementation, and even further, its evaluation and continuation or modification. Expertise in the form of policy advice is already widely available in and to public administrations, to well-established professional organizations like medical societies and, of course, to large private-sector organizations with commercial or financial interests in the health sector. We need more health actors to join the fray and move from their traditional position of advocacy to a fuller commitment to the development of policy capacity, with all that it entails in terms of leadership and social responsibility. PMID:25905476

  1. [Mental capacity of psychiatric patients].

    Science.gov (United States)

    Wu, Kevin Chien-Chang

    2010-12-01

    Nearly every society maintains legal norms that define those members of society qualified to participate in social affairs. Mental capacity and legal competence are deemed necessary conditions for legal actions to have legal validity. On Nov. 23, 2009, newly revised adult guardianship provisions came into effect in Taiwan. However, there has been lack of discussion with regard to how assessments of mental capacity and legal competence should be conducted on psychiatric patients. This paper reviewed relevant overseas literature on this subject and followed common practice in separating legal mental capacity into causal and functional components. The causal component predicates the diseases and illnesses that render the disability, while the functional component represents legally substantial impairments in terms of cognition, emotion and behavior. The paper explored functional component contents, including finance management, individual health care, independence in daily life, interpersonal relationships and communing. Findings pointed out that in setting up competence standards, a trade-off between respect for autonomy and beneficence is unavoidable. As Taiwan does not have rich empirical data on competence assessments and decisions, collaboration between the legal and psychiatric professions is recommended to engage in relevant research to enhance legal consistencies and the science of competence assessment.

  2. Health Reform Requires Policy Capacity

    Directory of Open Access Journals (Sweden)

    Pierre-Gerlier Forest

    2015-05-01

    Full Text Available Among the many reasons that may limit the adoption of promising reform ideas, policy capacity is the least recognized. The concept itself is not widely understood. Although policy capacity is concerned with the gathering of information and the formulation of options for public action in the initial phases of policy consultation and development, it also touches on all stages of the policy process, from the strategic identification of a problem to the actual development of the policy, its formal adoption, its implementation, and even further, its evaluation and continuation or modification. Expertise in the form of policy advice is already widely available in and to public administrations, to well-established professional organizations like medical societies and, of course, to large private-sector organizations with commercial or financial interests in the health sector. We need more health actors to join the fray and move from their traditional position of advocacy to a fuller commitment to the development of policy capacity, with all that it entails in terms of leadership and social responsibility

  3. LAW CAPACITY WASTEWATER TREATMENT PLANTS

    Directory of Open Access Journals (Sweden)

    Nicoleta Luminiţa Jurj

    2012-01-01

    Full Text Available The question of small water users having no centralized wastewater collecting, cleaning and discharging system is of maximal actuality in Romania. Therefor economically efficient solutions are looked for. For disperse mountain villages, farms, or detached households traditional systems, with high maintenance expences because of long networks for small flows, can be economicaly not advantageos. Very small capacity treatement plants are a solution for such cases. The aim of the experimental part of the present work is to simulate situations, damages which can occur during running of a low capacity wastewater treatement plant. Low capacity hosehold wastewater treatement plants are economic alternatives which remove the disadvantages of emptyable basins namely the high costs, the frequvent empying operations, with unpleasant smelling, continous danger of groundwater infection, need for massive and expensive concrete buildings. The proposed plants are based on a classical treatement technology and need emptying of the exess mud only once or twice a year. In opposition with the case of classical plants, the mixture extracted from the proposed low cost systems does not smell and has a relatively low content of solid matter.

  4. Unlocking patients with mental disorders who were in restraints at home: a national follow-up study of China's new public mental health initiatives.

    Directory of Open Access Journals (Sweden)

    Lili Guan

    Full Text Available In 2005, China implemented a demonstration program known as "686" to scale-up nation-wide basic mental health services designed to improve access to evidence-based care and to promote human rights for people with severe mental disorders. As part of the 686 Program, teams "unlocked" and provided continuous mental health care to people with severe mental disorders who were found in restraints and largely untreated in their family homes. We implemented a nation-wide two-stage follow-up study to measure the effectiveness and sustainability of the "unlocking and treatment" intervention and its impact on the well-being of patients' families.266 patients unlocked from 2005 in "686" demonstration sites across China were recruited in Stage One of the study in 2009. In 2012, 230 of the 266 cases were re-interviewed (the Stage Two study. Outcome measures included the patient medication adherence and social functioning, family burden ratings, and relocking rate. We utilized pre-post tests to analyze the changes over time following the unlocking efforts.96% of patients were diagnosed with schizophrenia. Prior to unlocking, their total time locked ranged from two weeks to 28 years, with 32% having been locked multiple times. The number of persons regularly taking medicines increased from one person at the time of unlocking to 74% in 2009 and 76% in 2012. Pre-post tests showed sustained improvement in patient social functioning and significant reductions in family burden. Over 92% of patients remained free of restraints in 2012.Practice-based evidence from our study suggests an important model for protecting the human rights of people with mental disorders and keeping them free of restraints can be achieved by providing accessible, community based mental health services with continuity of care. China's "686" Program can inform similar efforts in low-resource settings where community locking of patients is practiced.

  5. The CRH-R₁ receptor mediates luteinizing hormone, prolactin, corticosterone and progesterone secretion induced by restraint stress in estrogen-primed rats.

    Science.gov (United States)

    Traslaviña, Guillermo A Ariza; Franci, Celso Rodrigues

    2011-11-01

    Acute stress has been shown to modify hypothalamus-pituitary-gonadal (HPG) axis activity. Corticotropin-releasing hormone (CRH), the principal regulator of the hypothalamus-pituitary-adrenal (HPA) axis, has been implicated as a mediator of stress-induced effects on the reproductive axis. The role of the specific CRH receptor subtypes in this response is not completely understood. In the current study, we investigated the role of the CRH-R(1) receptor on luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), progesterone (P) and corticosterone (CT) secretion in stress-induced responses under the influence of estrogen (E(2)). Estrogen-primed ovariectomized rats (estradiol cypionate, 10 μg sc) received an i.v. administration of antalarmin (0.1 or 1mg/kg), a selective CRH-R(1) antagonist, or vehicle before restraint stress for 40 min. Seven blood samples were collected from two experimental groups (one from 10:00 h to 14:00 h and the other from 10:00 h to 18:00 h). An increase of plasma LH induced by restraint acute-stress was followed by alteration of the secretion pattern in the estrogen-induced afternoon surge. In a similar manner, we observed a suppression of the afternoon surge in plasma FSH, a delay of E(2)-induced PRL secretion, and an increase in plasma P and CT. Antalarmin attenuated stress-induce LH increase, decreased CT and P secretion and blocked the stress effects on PRL secretion. These findings suggest that CRH-R(1) mediates, at least in part, the restraint stress effects on the HPA, PRL, and reproductive axes.

  6. Chronic exercise improves repeated restraint stress-induced anxiety and depression through 5HT1A receptor and cAMP signaling in hippocampus

    OpenAIRE

    Kim, Mun Hee; Leem, Yea Hyun

    2014-01-01

    [Purpose] Mood disorders such as anxiety and depression are prevalent psychiatric illness, but the role of 5HT1A in the anti-depressive effects of exercise has been rarely known yet. We investigated whether long-term exercise affected a depressive-like behavior and a hippocampal 5HT1A receptor-mediated cAMP/PKA/CREB signaling in depression mice model. [Methods] To induce depressive behaviors, mice were subjected to 14 consecutive days of restraint stress (2 hours/day). Depression-like behavio...

  7. Demand side management in households. Potentials and restraints of short-term power supply; Demand Side Management in Haushalten. Potenziale und Hemmnisse fuer kurzfristige Leistungsbereitstellung

    Energy Technology Data Exchange (ETDEWEB)

    Roon, Serafin von; Gobmaier, Thomas [FfE Forschungsstelle fuer Energiewirtschaft e.V., Muenchen (Germany); Huck, Malte

    2010-07-01

    Within the project ''Wind energy - balancing forecast errors'' we examine potentials, restraints and costs of various options for balancing forecast errors of wind power generation. One possibility of providing this backup power could be to practice Demand Side Management (DSM) of household appliances. The integration of these appliances in a DSM network is facilitated by standardized data transmission procedures and the increasing deployment of microprocessors. Due to the low power consumption of the switchable devices no DSM measures are implemented in the household sector so far, despite the numerous appliances. (orig.)

  8. The utility of geometrical and chemical restraint information extracted from predicted ligand-binding sites in protein structure refinement.

    Science.gov (United States)

    Brylinski, Michal; Lee, Seung Yup; Zhou, Hongyi; Skolnick, Jeffrey

    2011-03-01

    Exhaustive exploration of molecular interactions at the level of complete proteomes requires efficient and reliable computational approaches to protein function inference. Ligand docking and ranking techniques show considerable promise in their ability to quantify the interactions between proteins and small molecules. Despite the advances in the development of docking approaches and scoring functions, the genome-wide application of many ligand docking/screening algorithms is limited by the quality of the binding sites in theoretical receptor models constructed by protein structure prediction. In this study, we describe a new template-based method for the local refinement of ligand-binding regions in protein models using remotely related templates identified by threading. We designed a Support Vector Regression (SVR) model that selects correct binding site geometries in a large ensemble of multiple receptor conformations. The SVR model employs several scoring functions that impose geometrical restraints on the Cα positions, account for the specific chemical environment within a binding site and optimize the interactions with putative ligands. The SVR score is well correlated with the RMSD from the native structure; in 47% (70%) of the cases, the Pearson's correlation coefficient is >0.5 (>0.3). When applied to weakly homologous models, the average heavy atom, local RMSD from the native structure of the top-ranked (best of top five) binding site geometries is 3.1Å (2.9Å) for roughly half of the targets; this represents a 0.1 (0.3)Å average improvement over the original predicted structure. Focusing on the subset of strongly conserved residues, the average heavy atom RMSD is 2.6Å (2.3Å). Furthermore, we estimate the upper bound of template-based binding site refinement using only weakly related proteins to be ∼2.6Å RMSD. This value also corresponds to the plasticity of the ligand-binding regions in distant homologues. The Binding Site Refinement (BSR

  9. On the Performance Evaluation of Effective Incentive and Restraint Mechanisms of Professional Managers%有效激励与约束机制的职业经理人绩效评价探析

    Institute of Scientific and Technical Information of China (English)

    魏秋

    2011-01-01

    在对企业职业经理人的激励与约束机制基本理论阐述和原因的分析基础上,归纳了现行的四种激励和约束机制类型并针对每一种类型进行了绩效考核分析,以期探索适合于我国企业职业经理人的有效激励与约束机制。%Based on the analysis of the basic theory explanation and reason of incentive and restraint mechanisms for enterprise of professional managers,the existing four kinds of incentive and restraint mechanisms are summarized,and each kind of performance evaluation is analyzed,then to explore the suitable effective incentive and restraint mechanisms for the enterprise of professional managers in China.

  10. 汽车正面碰撞乘员约束系统的安全性分析%Safety Analysis of Occupant Restraint System in Car Frontal Crash

    Institute of Scientific and Technical Information of China (English)

    吴丽丽; 郭世永

    2014-01-01

    根据正面碰撞乘员约束系统的结构,简要地介绍了某车型中乘员约束系统各部件的模型的建立。并对建立好的模型进行了仿真分析,假人的伤害情况结果表明,该车型的乘员约束系统对乘员起到了很好的保护作用。%In this paper, based on the structure of the occupant restraint system in frontal crash, the components of vehicle oc-cupant restraint system are briefly described, and the simulation analysis to the established model is made, the results of dum-my injury cases show that the vehicle occupant restraint system play a very good protection role for the crew.

  11. Capacity Building for Engineering Education

    DEFF Research Database (Denmark)

    de Graaff, Erik; Deboer, Jennifer

    2015-01-01

    The International Institute for Developing Engineering Academics (IIDEA) is a joint initiative from IFEES and SEFI, aiming to provide all the engineering education associations, institutions and other engineering education stakeholders a clearing house of high caliber and world-class engineering ...... and universities are being challenged to incorporate innovative tools in their classrooms as well as to prepare students to research and innovate themselves. The paper will present an overview of IIDEA activities and aims to evaluate the success of the capacity building workshops....

  12. Intraocular lens with accommodation capacity

    OpenAIRE

    Dorronsoro, Carlos; Alejandre, Nicolás; Bekesi, Nandor; Marcos, Susana

    2014-01-01

    Intraocular lens with accommodation capacity comprising a first optical member (1) having a dynamic optical power, to which a second optical member (2) with a fixed optical power is affixed, in such a manner that at least a central part of each of one of one of the curved surfaces (2a, 2b) of the second optical member (2) and of at least one of the surfaces (1a, 1b) of the first optical member (1) are in contact with each other, the second optical member (2) and the first optical member (1) p...

  13. Implementing Estimation of Capacity for Freeway Sections

    Directory of Open Access Journals (Sweden)

    Chang-qiao Shao

    2011-01-01

    Full Text Available Based on the stochastic concept for freeway capacity, the procedure of capacity estimation is developed. Due to the fact that it is impossible to observe the value of the capacity and to obtain the probability distribution of the capacity, the product-limit method is used in this paper to estimate the capacity. In order to implement estimation of capacity using this technology, the lifetime table based on statistical methods for lifetime data analysis is introduced and the corresponding procedure is developed. Simulated data based on freeway sections in Beijing, China, were analyzed and the results indicate that the methodology and procedure are applicable and validated.

  14. Primal and dual approaches to fishing capacity

    DEFF Research Database (Denmark)

    Kerstens, Kristiaan; Vestergaard, Niels

    2013-01-01

    Application of primal non-parametric approaches to estimation of fishing capacity provides useful disaggregated information about fishing firm’s capacities utilizations. A potentially serious issue is that the estimated capacity utilization rates can be relatively low. This may call for reductions...... in the fishing fleet that are political impossible to defend. In this paper two modifications of the traditional approach are explored. First, non-convex technologies are introduced and it is shown how the primal non-parametric approach leads to different capacity utilization rates. Then capacity utilization...... these capacity measures on the Pacific albacore tuna fishery to document the impact of convexity....

  15. Iran outlines oil productive capacity

    International Nuclear Information System (INIS)

    National Iranian Oil Co. (NIOC) tested production limits last month to prove a claim of 4 million bd capacity made at September's meeting of the organization of Petroleum Exporting Countries. Onshore fields account for 3.6 million bd of the total, with offshore fields providing the rest. NIOC plans to expand total capacity to 4.5 million bd by April 1993, consisting of 4 million b/d onshore and 500,000 b/d offshore. Middle East Economic Survey says questions remain about completion dates for gas injection, drilling, and offshore projects, but expansion targets are attainable within the scheduled time. NIOC said some slippage may be unavoidable, but it is confident the objective will be reached by third quarter 1993 at the latest. More than 60 rigs are working or about to be taken under contract to boost development drilling in onshore fields and provide gas injection in some. NIOC has spent $3.2 billion in foreign exchange on the drilling program in the last 2 1/2 years

  16. World nuclear power plant capacity

    International Nuclear Information System (INIS)

    This report provides the background information for statistics and analysis developed by NUKEM in its monthly Market Report on the Nuclear Fuel Cycle. The assessments in this Special Report are based on the continuous review of individual nuclear power plant projects. This Special Report begins with tables summarizing a variety of nuclear power generating capacity statistics for 1990. It continues with a brief review of the year's major events regarding each country's nuclear power program. The standard NUKEM Market Report tables on nuclear plant capacity are given on pages 24 and 25. Owing to space limitations, the first year shown is 1988. Please refer to previous Special Reports for data covering earlier years. Detailed tables for each country list all existing plants as well as those expected by NUKEM to be in commercial operation by the end of 2005. An Appendix containing a list of abbreviations can be found starting on page 56. Only nuclear power plants intended for civilian use are included in this Special Report. Reactor lifetimes are assumed to be 35 years for all light water reactors and 30 years for all other reactor types, unless other data or definite decommissioning dates have been published by the operators. (orig./UA)

  17. Study of Incentive and Restraint Mechanism of Green Government subsidized Housing%绿色保障性住房激励约束机制研究

    Institute of Scientific and Technical Information of China (English)

    高山; 付光辉

    2014-01-01

    It is the general trendand in line with the demands of Scientific Development Outlook to developing green government -subsidized housing in China .On the basis of incentive and restraint theory ,this article in-vestigates the relationship between government ,construction -related enterprises and households during the development of green government -subsidized housing process ,and proposes a framework of incentive and restraint mechanismsin order to achieve the win -win among three parts andpromote the development of green government -subsidized housing .%指出了发展绿色保障性住房是大势所趋,符合科学发展观的要求。对政府、建筑相关企业、消费者进行了研究,分析了三者的委托代理关系,结合激励约束理论,提出了发展绿色保障性住房激励约束机制的框架,以促使三者的利益趋于一致,实现三方共赢,推动绿色保障性住房的快速发展。

  18. Inhalation administration of valerena-4,7(11)-diene from Nardostachys chinensis roots ameliorates restraint stress-induced changes in murine behavior and stress-related factors.

    Science.gov (United States)

    Takemoto, Hiroaki; Omameuda, Yuka; Ito, Michiho; Fukuda, Tatsuo; Kaneko, Shuji; Akaike, Akinori; Kobayashi, Yoshinori

    2014-01-01

    Dried Nardostachys chinensis roots contain sesquiterpenoids that are widely used as herbal tranquilizers. We previously identified the highly sedative sesquiterpenoid valerena-4,7(11)-diene (VLD) from this plant. In the present study, we investigated stress reducing effects of VLD and the associated mechanisms of action. Application of 15-min restraint stresses induced excitatory behaviors in mice. Immobility times in the forced swim test and sleeping times in the pentobarbital sleep test were shortened in the stressed group by 47% and 43%, respectively, compared with the control group. Furthermore, restraint stress increased serum corticosterone levels by 75%, and cerebral serotonin (5-HT) and dopamine (DA) levels. Inhaled VLD (300 µg/cage) suppressed stress-induced excitatory behaviors and significantly reduced stress-induced blood corticosterone, cerebral 5-HT, and DA levels. These results suggest that VLD interacts with the hypothalamic-pituitary-adrenal axis and the sympathetic-adrenomedullary system. These interactions appear to involve GABAergic and D2 antagonist activities. Moreover, tests in anosmic and intravenously treated mice showed that the sedative effect of inhaled VLD was expressed via olfactory stimulation and pulmonary absorption. Although more studies are required to further elucidate the properties of this compound, our studies suggest that VLD may be an effective anti-stress aromatherapy for humans. PMID:24882416

  19. Assessing Competence of Broccoli Consumption on Inflammatory and Antioxidant Pathways in Restraint-Induced Models: Estimation in Rat Hippocampus and Prefrontal Cortex

    Directory of Open Access Journals (Sweden)

    Leila Khalaj

    2013-01-01

    Full Text Available A growing body of evidence advocated the protective and therapeutic potential of natural compounds and phytochemicals used in diets against pathological conditions. Herein, the outcome of dietary whole broccoli consumption prior to restraint stress has been investigated in the hippocampus and prefrontal cortex of male rats, two important regions involved in the processing of responses to stressful events. Interestingly, a region-specific effect was detected regarding some of antioxidant defense system factors: nuclear factor erythroid-derived 2-related factor 2 (Nrf-2 antioxidant pathway, mitochondrial prosurvival proteins involved in mitochondrial biogenesis, and apoptotic cell death proteins. Dietary broccoli supplementation modulated the restraint-induced changes towards a consistent overall protection in the hippocampus. In the prefrontal cortex, however, despite activation of most of the protective factors, presumably as an attempt to save the system against the stress insult, some detrimental outcomes such as induced malate dehydrogenase (MDA level and cleaved form of caspase-3 were detectable. Such diversity may be attributed in one hand to the different basic levels and/or availability of defensive mechanisms within the two studied cerebral regions, and on the other hand to the probable dose-dependent and hormetic effects of whole broccoli. More experiments are essential to demonstrate these assumptions.

  20. Combined use of spatial restraint stress and middle cerebral artery occlusion is a novel model of post-stroke depression in mice.

    Science.gov (United States)

    Zhang, Gaocai; Chen, Li; Yang, Lingli; Hua, Xiaodong; Zhou, Beiqun; Miao, Zhigang; Li, Jizhen; Hu, Hua; Namaka, Michael; Kong, Jiming; Xu, Xingshun

    2015-01-01

    Post stroke depression (PSD) is one of the most common complications of ischemic stroke. At present, the underlying mechanisms are unclear, largely because there are no reliable, valid and reproducible animal models of PSD. Here we report a novel animal model of PSD that displays consistent and reliable clinical features of hemiplegic stroke. The animal model encompasses a combination of the middle cerebral artery occlusion (MCAO) and spatial restraint stress. We found that a 60-minute MCAO followed by spatial restraint stress for 2 h daily for 2 to 4 weeks from the fourth day after MCAO induced PSD-like depressive phenotypes in mice. Importantly, the mice showed exacerbated deficits of neurological functions and decreased body weights, which were accompanied with reduced levels of brain derived neurotrophic factor and neurotransmitters including serotonin and dopamine. In addition, we identified increased levels of serum cortisol in our PSD mice. Finally, we found that mice with PSD were responsive to the tri-cyclic antidepressant imipramine as evidenced by their attenuated depressive behaviors, increased body weights, recovered brain serotonin levels, and decreased serum cortisol levels. This mouse model replicates multiple features of human post-stroke depression and thus provides a new model for the investigation of PSD. PMID:26572587

  1. Temporal changes of the adrenal endocrine system in a restraint stressed mouse and possibility of postmortem indicators of prolonged psychological stress.

    Science.gov (United States)

    Hayashi, Takahito; Ikematsu, Kazuya; Abe, Yuki; Ihama, Yoko; Ago, Kazutoshi; Ago, Mihoko; Miyazaki, Tetsuji; Ogata, Mamoru

    2014-07-01

    We investigated temporal changes of adrenal endocrine systems through the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenomedullary (SA) axis in restraint stressed mice. Restraint stress for 1 day to 3 weeks caused a significant increase in serum levels of ACTH and glucocorticoids accompanied with an increase in adrenal weights, indicating activation of the HPA axis. Reflecting the overproduction of glucocorticoids, adrenal cholesterol content decreased. Moreover, adrenal gene expression involved in cholesterol supply, including scavenger receptor-class B type I, HMG-CoA reductase, and hormone-sensitive lipase, was increased over the same period. After 4 weeks stress, all of these changes returned to control levels. In contrast, adrenal gene expression of chromogranin A, which is cosecreted with catecholamine via the SA axis, was increased with 1 day to 2 weeks of stress, and decreased with 3-4 weeks of stress. Our results suggest that analyses of adrenal endocrine systems based on the combination of several markers examined here would be useful for not only proving prolonged psychological stress experience but also determining its duration.

  2. Possible Involvement of µ Opioid Receptor in the Antidepressant-Like Effect of Shuyu Formula in Restraint Stress-Induced Depression-Like Rats

    Directory of Open Access Journals (Sweden)

    Fu-rong Wang

    2015-01-01

    Full Text Available Recently μ opioid receptor (MOR has been shown to be closely associated with depression. Here we investigated the action of Shuyu, a Chinese herbal prescription, on repeated restraint stress induced depression-like rats, with specific attention to the role of MOR and the related signal cascade. Our results showed that repeated restraint stress caused significant depressive-like behaviors, as evidenced by reduced body weight gain, prolonged duration of immobility in forced swimming test, and decreased number of square-crossings and rearings in open field test. The stress-induced depression-like behaviors were relieved by Shuyu, which was accompanied by decreased expression of MOR in hippocampus. Furthermore, Shuyu upregulated BDNF protein expression, restored the activity of CREB, and stimulated MEK and ERK phosphorylation in hippocampus of stressed rats. More importantly, MOR is involved in the effects of Shuyu on these depression-related signals, as they can be strengthened by MOR antagonist CTAP. Collectively, these data indicated that the antidepressant-like properties of Shuyu are associated with MOR and the corresponding CREB, BDNF, MEK, and ERK signal pathway. Our study supports clinical use of Shuyu as an effective treatment of depression and also suggests that MOR might be a target for treatment of depression and developing novel antidepressants.

  3. TREC-SAVE: a randomised trial comparing mechanical restraints with use of seclusion for aggressive or violent seriously mentally ill people: study protocol for a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Ferreira Marco AV

    2011-07-01

    Full Text Available Abstract Background Thousands of people whose aggression is thought due to serious mental illness are secluded or restrained every day. Without fair testing these techniques will continue to be used outside of a rigorous evidence base. With such coercive treatment this leaves all concerned vulnerable to abuse and criticism. This paper presents the protocol for a randomised trial comparing seclusion with restraints for people with serious mental illnesses. Methods/Design Setting-General psychiatric wards of a large psychiatric hospital in Rio de Janeiro, Brazil. Participants-Anyone aggressive or violent suspected or known to have serious mental illness for whom restriction is felt to be indicated by nursing and medical staff, but also for whom they are unsure whether seclusion or restraint would be indicated. Interventions-The standard care of either strong cotton banding to edge of bed with medications as indicated and close observation or the other standard care of use of a minimally furnished seclusion room but with open but barred windows onto the nursing station. Outcomes-time to restrictions lifted, early change of treatment, additional episodes, adverse effects/events, satisfaction with care during episode. Duration-2 weeks. Identifier: ISRCTN 49454276 http://www.controlled-trials.com/ISRCTN49454276

  4. Analytical Expression for the MIMO Channel Capacity

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yifei; ZHAO Ming; XIAO Limin; WANG Jing

    2006-01-01

    This paper presents analytical expressions for the multiple-input multiple-output (MIMO) channel capacity in frequency-flat Rayleigh fading environments. An exact analytical expression is given for the ergodic capacity for single-input multiple-output (SIMO) channels. The analysis shows that the SIMO channel capacity can be approximated by a Gaussian random variable and that the MIMO channel capacity can be approximated as the sum of multiple SIMO capacities. The SIMO channel results are used to derive approximate closed-form expressions for the MIMO channel ergodic capacity and the complementary cumulative distribution function (CCDF) of the MIMO channel capacity (outage capacity). Simulations show that these theoretical results are good approximations for MIMO systems with an arbitrary number of transmit or receive antennas. Moreover, these analytical expressions are relatively simple which makes them very useful for practical computations.

  5. Energy modelling and capacity building

    International Nuclear Information System (INIS)

    The Planning and Economic Studies Section of the IAEA's Department of Nuclear Energy is focusing on building analytical capacity in MS for energy-environmental-economic assessments and for the elaboration of sustainable energy strategies. It offers a variety of analytical models specifically designed for use in developing countries for (i) evaluating alternative energy strategies; (ii) assessing environmental, economic and financial impacts of energy options; (iii) assessing infrastructure needs; (iv) evaluating regional development possibilities and energy trade; (v) assessing the role of nuclear power in addressing priority issues (climate change, energy security, etc.). These models can be used for analysing energy or electricity systems, and to assess possible implications of different energy, environmental or financial policies that affect the energy sector and energy systems. The models vary in complexity and data requirements, and so can be adapted to the available data, statistics and analytical needs of different countries. These models are constantly updated to reflect changes in the real world and in the concerns that drive energy system choices. They can provide thoughtfully informed choices for policy makers over a broader range of circumstances and interests. For example, they can readily reflect the workings of competitive energy and electricity markets, and cover such topics as external costs. The IAEA further offers training in the use of these models and -just as important- in the interpretation and critical evaluation of results. Training of national teams to develop national competence over the full spectrum of models, is a high priority. The IAEA maintains a broad spectrum of databanks relevant to energy, economic and environmental analysis in MS, and make these data available to analysts in MS for use in their own analytical work. The Reference Technology Data Base (RTDB) and the Reference Data Series (RDS-1) are the major vehicles by which we

  6. Network error correction with unequal link capacities

    OpenAIRE

    Kim, Sukwon; Ho, Tracey; Effros, Michelle; Avestimehr, Amir Salman

    2010-01-01

    We study network error correction with unequal link capacities. Previous results on network error correction assume unit link capacities. We consider network error correction codes that can correct arbitrary errors occurring on up to z links. We find the capacity of a network consisting of parallel links, and a generalized Singleton outer bound for any arbitrary network. We show by example that linear coding is insufficient for achieving capacity in general. In our exampl...

  7. Can Science and Technology Capacity be Measured?

    CERN Document Server

    Wagner, Caroline S; Dutta, Arindum

    2015-01-01

    The ability of a nation to participate in the global knowledge economy depends to some extent on its capacities in science and technology. In an effort to assess the capacity of different countries in science and technology, this article updates a classification scheme developed by RAND to measure science and technology capacity for 150 countries of the world.

  8. The heat capacity mapping mission

    Science.gov (United States)

    Short, N. M.

    1981-01-01

    The first in a series of low cost Atmospheric Explorer Satellites, the Heat Capacity Mapping Mission (HCMM) was designed to evaluate the utility of thermal inertial and other thermal and reflectance data for: (1) discriminating bedrock and unconsolidated regolith types; (2) mapping soil moisture; (3) measuring plant canopy temperatures; (4) examining thermal circulation in large bodies of water; and (5) monitoring urban heat islands. Final reports from the HCMM investigator's program are beginning to define the utility of day/the night thermal data. Under favorable circumstances, some major rock types can be identified, soil moisture in extensive agricultural and alluvial terrains can be detected and at least semiqualitatively assessed; and circulation of currents in large bodies of water can be followed by noting thermal patterns.

  9. Transmission capacity of wireless networks

    CERN Document Server

    Weber, Steven

    2012-01-01

    Transmission capacity (TC) is a performance metric for wireless networks that measures the spatial intensity of successful transmissions per unit area, subject to a constraint on the permissible outage probability (where outage occurs when the SINR at a receiver is below a threshold). This volume gives a unified treatment of the TC framework that has been developed by the authors and their collaborators over the past decade. The mathematical framework underlying the analysis (reviewed in Ch. 2) is stochastic geometry: Poisson point processes model the locations of interferers, and (stable) shot noise processes represent the aggregate interference seen at a receiver. Ch. 3 presents TC results (exact, asymptotic, and bounds) on a simple model in order to illustrate a key strength of the framework: analytical tractability yields explicit performance dependence upon key model parameters. Ch. 4 presents enhancements to this basic model --- channel fading, variable link distances, and multi-hop. Ch. 5 presents four...

  10. The sensitizing capacity of atranorin.

    Science.gov (United States)

    Sandberg, M; Thune, P

    1984-09-01

    The allergenic potential of the aromatic lichen substance atranorin has been investigated by means of the guinea pig maximization test of Magnusson & Kligman. Sensitivity was induced in 30% of the animals, which corresponds to a moderate allergenic capacity (grade III). This is in agreement with the clinically-observed frequency of 1.5% among our patients. A modified photoallergy test on the same animals was performed, but irradiation did not increase the number of positive reactions. 4 patients with proven contact sensitivity to atranorin, evernic, usnic or physodic acid, were examined with different dilutions from 0.001 to 0.1%. Irradiation of the test series did not provoke any clear-cut photoallergic reaction. PMID:6499416

  11. Future High Capacity Backbone Networks

    DEFF Research Database (Denmark)

    Wang, Jiayuan

    This thesis - Future High Capacity Backbone Networks - deals with the energy efficiency problems associated with the development of future optical networks. In the first half of the thesis, novel approaches for using multiple/single alternative energy sources for improving energy efficiency...... is studied in details with dynamic network simulations using OPNET. Dynamic routing optimization methods are proposed. The influences of re-routing and load-balancing factors on the algorithm are evaluated with a focus on different re-routing thresholds. Results from dynamic network simulations show that re...... aiming for reducing the dynamic part of the energy consumption of the network may increase the fixed part of the energy consumption meanwhile. In the second half of the thesis, the conflict between energy efficiency and Quality of Service (QoS) is addressed by introducing a novel software defined...

  12. Capacity Analysis for Dynamic Space Networks

    Institute of Scientific and Technical Information of China (English)

    Yang Lu; Bo Li; Wenjing Kang; Gongliang Liu; Xueting Li

    2015-01-01

    To evaluate transmission rate of highly dynamic space networks, a new method for studying space network capacity is proposed in this paper. Using graph theory, network capacity is defined as the maximum amount of flows ground stations can receive per unit time. Combined with a hybrid constellation model, network capacity is calculated and further analyzed for practical cases. Simulation results show that network capacity will increase to different extents as link capacity, minimum ground elevation constraint and satellite onboard processing capability change. Considering the efficiency and reliability of communication networks, how to scientifically design satellite networks is also discussed.

  13. Pile Load Capacity – Calculation Methods

    Directory of Open Access Journals (Sweden)

    Wrana Bogumił

    2015-12-01

    Full Text Available The article is a review of the current problems of the foundation pile capacity calculations. The article considers the main principles of pile capacity calculations presented in Eurocode 7 and other methods with adequate explanations. Two main methods are presented: α – method used to calculate the short-term load capacity of piles in cohesive soils and β – method used to calculate the long-term load capacity of piles in both cohesive and cohesionless soils. Moreover, methods based on cone CPTu result are presented as well as the pile capacity problem based on static tests.

  14. Capacity analysis of vehicular communication networks

    CERN Document Server

    Lu, Ning

    2013-01-01

    This SpringerBrief focuses on the network capacity analysis of VANETs, a key topic as fundamental guidance on design and deployment of VANETs is very limited. Moreover, unique characteristics of VANETs impose distinguished challenges on such an investigation. This SpringerBrief first introduces capacity scaling laws for wireless networks and briefly reviews the prior arts in deriving the capacity of VANETs. It then studies the unicast capacity considering the socialized mobility model of VANETs. With vehicles communicating based on a two-hop relaying scheme, the unicast capacity bound is deriv

  15. Capacity Value of Concentrating Solar Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Madaeni, S. H.; Sioshansi, R.; Denholm, P.

    2011-06-01

    This study estimates the capacity value of a concentrating solar power (CSP) plant at a variety of locations within the western United States. This is done by optimizing the operation of the CSP plant and by using the effective load carrying capability (ELCC) metric, which is a standard reliability-based capacity value estimation technique. Although the ELCC metric is the most accurate estimation technique, we show that a simpler capacity-factor-based approximation method can closely estimate the ELCC value. Without storage, the capacity value of CSP plants varies widely depending on the year and solar multiple. The average capacity value of plants evaluated ranged from 45%?90% with a solar multiple range of 1.0-1.5. When introducing thermal energy storage (TES), the capacity value of the CSP plant is more difficult to estimate since one must account for energy in storage. We apply a capacity-factor-based technique under two different market settings: an energy-only market and an energy and capacity market. Our results show that adding TES to a CSP plant can increase its capacity value significantly at all of the locations. Adding a single hour of TES significantly increases the capacity value above the no-TES case, and with four hours of storage or more, the average capacity value at all locations exceeds 90%.

  16. Assessing urban adaptive capacity to climate change.

    Science.gov (United States)

    Araya-Muñoz, Dahyann; Metzger, Marc J; Stuart, Neil; Wilson, A Meriwether W; Alvarez, Luis

    2016-12-01

    Despite the growing number of studies focusing on urban vulnerability to climate change, adaptive capacity, which is a key component of the IPCC definition of vulnerability, is rarely assessed quantitatively. We examine the capacity of adaptation in the Concepción Metropolitan Area, Chile. A flexible methodology based on spatial fuzzy modelling was developed to standardise and aggregate, through a stepwise approach, seventeen indicators derived from widely available census statistical data into an adaptive capacity index. The results indicate that all the municipalities in the CMA increased their level of adaptive capacity between 1992 and 2002. However, the relative differences between municipalities did not change significantly over the studied timeframe. Fuzzy overlay allowed us to standardise and to effectively aggregate indicators with differing ranges and granularities of attribute values into an overall index. It also provided a conceptually sound and reproducible means of exploring the interplay of many indicators that individually influence adaptive capacity. Furthermore, it captured the complex, aggregated and continued nature of the adaptive capacity, favouring to deal with gaps of data and knowledge associated with the concept of adaptive capacity. The resulting maps can help identify municipalities where adaptive capacity is weak and identify which components of adaptive capacity need strengthening. Identification of these capacity conditions can stimulate dialogue amongst policymakers and stakeholders regarding how to manage urban areas and how to prioritise resources for urban development in ways that can also improve adaptive capacity and thus reduce vulnerability to climate change.

  17. Network error correction with unequal link capacities

    CERN Document Server

    Kim, Sukwon; Effros, Michelle; Avestimehr, Amir Salman

    2010-01-01

    This paper studies the capacity of single-source single-sink noiseless networks under adversarial or arbitrary errors on no more than z edges. Unlike prior papers, which assume equal capacities on all links, arbitrary link capacities are considered. Results include new upper bounds, network error correction coding strategies, and examples of network families where our bounds are tight. An example is provided of a network where the capacity is 50% greater than the best rate that can be achieved with linear coding. While coding at the source and sink suffices in networks with equal link capacities, in networks with unequal link capacities, it is shown that intermediate nodes may have to do coding, nonlinear error detection, or error correction in order to achieve the network error correction capacity.

  18. Uranium enrichment: technology, economics, capacity

    International Nuclear Information System (INIS)

    Large-scale enrichment of uranium has now been carried out for 40 years. While the gaseous diffusion process was the original choice of several countries and continues today to provide the major component of the world production of separative work, the last two decades have witnessed the development of a number of alternative processes for enrichment. These processes, which are being studied and deployed around the world, offer a wide range of technical and economic characteristics which will be useful in assuring adequate capacity to meet projected reactor fuel market needs through the rest of this century at competitive prices. With present uncertainties in future enriched uranium needs, it is apparent that flexibility in the deployment and operation of any enrichment process will be one of the prime considerations for the future. More economical production of separative work not only can have a beneficial impact on reactor fuel costs, but also tends to conserve natural uranium resources. This paper reviews the world scene in the enrichment component of the fuel cycle, including existing or planned commercial-scale facilities and announced R and D efforts on various processes

  19. The COSPAR Capacity Building Initiative

    Science.gov (United States)

    Gabriel, C.; Willmore, P.; Méndez, M.; Mathieu, P.-P.; Santolik, O.; Smith, R.

    2011-07-01

    The COSPAR Capacity Building Workshops have been conceived to meet the following objectives: (1) To increase knowledge and use of public archives of space data in order both to broaden the scope of research programs in developing countries and to ensure that scientists in those countries are aware of the full range of facilities that are available to them; (2) To provide highly-practical instruction in the use of these archives and the associated publicly-available software; and (3) To foster personal links between participants and experienced scientists attending the workshops to contribute to reducing the isolation often experienced by scientists in developing countries. Since 2001 a total of twelve workshops have been successfully held in different scientific areas (X-ray, Gamma-ray, Space Optical and UV Astronomy, Magnetospheric Physics, Space Oceanography and Planetary Science) in nine developing countries (Brazil, India, China, South Africa, Morocco, Romania, Uruguay, Egypt and Malaysia). In this contribution we discuss the modalities of the workshops, the experience so-far gained, and the future including collaborations with other institutions sharing the aim of increasing the scientific activities in developing countries.

  20. Advancing leadership capacity in nursing.

    Science.gov (United States)

    Scott, Elaine S; Miles, Jane

    2013-01-01

    To address the potential shortage of nurse leaders, the profession must evaluate current strategies in both education and practice. While many new graduates dream of becoming a nurse practitioner or nurse anesthetist, few transition into practice with the goal of becoming a nurse leader. To increase the number of nurses capable of leadership, the profession must address 2 critical issues. First, effort must be made to augment faculty and students' conceptualization of nursing such that leadership is seen as a dimension of practice for all nurses, not just those in formal leadership roles. In so doing, leadership identity development would be seen as a part of becoming an expert nurse. Second, a comprehensive conceptual framework for lifelong leadership development of nurses needs to be designed. This framework should allow for baseline leadership capacity building in all nurses and advanced leadership development for those in formal administrative and advanced practice roles. The knowledge and skill requirements for quality improvement and patient safety have been explored and recommendations made for Quality and Safety Education for Nurses, but parallel work needs to be done to outline educational content, objectives, and effective pedagogy for advancing leadership development in nursing students at all levels.

  1. HIV communication capacity strengthening: a critical review.

    Science.gov (United States)

    Lettenmaier, Cheryl; Kraft, Joan Marie; Raisanen, Keris; Serlemitsos, Elizabeth

    2014-08-15

    HIV communication is most effective and sustainable when it is designed and implemented locally and tailored to the local context. This requires capacity strengthening at national, subnational, and community levels. Through a review of the published and selected "grey" literature, we examine HIV communication capacity strengthening: definitions, measurements, implementation, and effects. We found limited documentation of HIV communication capacity needs or systematic approaches to address them. Most HIV communication capacity strengthening to date has focused on building individual competencies to design and manage social and behavior change communication programs through training courses, often coupled with networking opportunities for participants, post-training mentoring, and technical assistance. A few of these efforts have been evaluated through pre- and post-training tests and qualitative interviews with participants and have shown potential for improvement in individual skills and knowledge. Health communication capacity assessment tools that measure individual and organizational competencies exist, but they have most often been used to identify capacity building needs, not for evaluating capacity strengthening efforts. A new definition of capacity strengthening, grown out of recent efforts to improve effectiveness of international health and development programs, focuses on improving organizational and societal systems that support performance and individual competencies. We propose a holistic model for HIV communication capacity strengthening and call for rigorous documentation and evaluation to determine and scale-up optimal capacity building interventions for strengthening social and behavior change communication for HIV prevention, care, and treatment in developing countries. PMID:25007200

  2. What can we learn from North American transport energy demand restraint policies of the 1970s and 1980s and public reactions to them?

    Energy Technology Data Exchange (ETDEWEB)

    Lee-Gosselin, M.E.H. [Ecole Superieure d' Amenagement du territoire et de Developpement regional ESAD and Centre for research on planning and development CRAD, Universite Laval, 1616 Pavillon F-A Savard, Quebec, PQ, G1V 0A6 (Canada)

    2010-05-15

    This paper offers a North American perspective on the possible reaction of the general public to regulatory instruments addressing energy consumption, and by implication, carbon emissions. Its purpose is to reflect on some of the lessons learnt from research on consumer behaviour undertaken by the author and colleagues in the wake of the oil shortages of 1973 (OPEC embargo) and 1979 (interruption of Iranian production). The paper does not, therefore, provide an extensive review of related literature. It first outlines very briefly the policy context of the past 30 years and the classes of transport energy demand restraint policies of the 1970s and 1980s. It then describes some key lessons from our research during those two decades and concludes with some speculation on their relevance to demand-side management that is motivated by concerns over greenhouse gas emissions.

  3. The design and application of self-restraint multi-purpose joint%自制多用接头的设计及应用

    Institute of Scientific and Technical Information of China (English)

    李红霞

    2014-01-01

    The joint of rubber pipes of oxygen bag and oxygen tube often fell off because their caliber did not match with each other and there was no special joint,which affected nursing services.Self-restraint multi-purpose joint made of syringe was used in the clinical nursing services and had obtained satisfactory effects,which was worthy of clinical popularization and application.%氧气袋上的橡胶管与吸氧管口径不匹配且无专用接头,经常出现连接处松脱现象,影响护理工作。采用注射器等自制多用接头应用于临床护理工作中,取得了满意效果,值得临床推广应用。

  4. Study on Motivation and Restraint Mechanism for Employees of Highway Transport Enterprises%公路运输企业员工激励约束机制研究

    Institute of Scientific and Technical Information of China (English)

    郭俊发

    2014-01-01

    在论证公路运输企业建立规范的员工激励约束机制的必要性的基础上,分析了目前公路运输企业员工激励约束机制方面存在的问题。结合对竞争性公路运输企业员工所着重的激励因素问卷调查,提出应以人力资源价值链管理理论为指导,在激励制度设计中融合约束,全面建设“三体系”和“一配套”工程,即岗位职级激励约束体系、全面绩效管理激励约束体系、薪酬激励约束体系和非薪酬配套机制,从而构建完整而有效的公路运输企业员工激励约束机制。%On the demonstration of necessity to establish standard motivation and restraint mechanism for employees of highway transport enterprises,the existing problems of the current motivation and restraint mechanism for employees of highway transport enterprises have been analyzed.Based on questionnaire investigations on main motivation factors for employees of highway transport enterprises,it has been pointed out that "three system"and "one supporting"shall be established,including motivation and restraint system of job ranking,comprehensive performance management,com-pensation and non-compensation supporting system,which has been based on human resource value chain management theory and combined restraints with motivation,so a complete and efficient motivation and restraint mechanism for em-ployees of highway transport enterprises could be established.

  5. Study on Motivation and Restraint Mechanism for Employees of Highway Transport Enterprises%公路运输企业员工激励约束机制研究

    Institute of Scientific and Technical Information of China (English)

    郭俊发

    2014-01-01

    On the demonstration of necessity to establish standard motivation and restraint mechanism for employees of highway transport enterprises,the existing problems of the current motivation and restraint mechanism for employees of highway transport enterprises have been analyzed.Based on questionnaire investigations on main motivation factors for employees of highway transport enterprises,it has been pointed out that "three system"and "one supporting"shall be established,including motivation and restraint system of job ranking,comprehensive performance management,com-pensation and non-compensation supporting system,which has been based on human resource value chain management theory and combined restraints with motivation,so a complete and efficient motivation and restraint mechanism for em-ployees of highway transport enterprises could be established.%在论证公路运输企业建立规范的员工激励约束机制的必要性的基础上,分析了目前公路运输企业员工激励约束机制方面存在的问题。结合对竞争性公路运输企业员工所着重的激励因素问卷调查,提出应以人力资源价值链管理理论为指导,在激励制度设计中融合约束,全面建设“三体系”和“一配套”工程,即岗位职级激励约束体系、全面绩效管理激励约束体系、薪酬激励约束体系和非薪酬配套机制,从而构建完整而有效的公路运输企业员工激励约束机制。

  6. Driver kinematic and muscle responses in braking events with standard and reversible pre-tensioned restraints: validation data for human models.

    Science.gov (United States)

    Osth, Jonas; Olafsdóttir, Jóna Marín; Davidsson, Johan; Brolin, Karin

    2013-11-01

    The objectives of this study are to generate validation data for human models intended for simulation of occupant kinematics in a pre-crash phase, and to evaluate the effect of an integrated safety system on driver kinematics and muscle responses. Eleven male and nine female volunteers, driving a passenger car on ordinary roads, performed maximum voluntary braking; they were also subjected to autonomous braking events with both standard and reversible pre-tensioned restraints. Kinematic data was acquired through film analysis, and surface electromyography (EMG) was recorded bilaterally for muscles in the neck, the upper extremities, and lumbar region. Maximum voluntary contractions (MVCs) were carried out in a driving posture for normalization of the EMG. Seat belt positions, interaction forces, and seat indentions were measured. During normal driving, all muscle activity was below 5% of MVC for females and 9% for males. The range of activity during steady state braking for males and females was 13-44% in the cervical and lumbar extensors, while antagonistic muscles showed a co-contraction of 2.3-19%. Seat belt pre-tension affects both the kinematic and muscle responses of drivers. In autonomous braking with standard restraints, muscle activation occurred in response to the inertial load. With pre-tensioned seat belts, EMG onset occurred earlier; between 71 ms and 176 ms after belt pre-tension. The EMG onset times decreased with repeated trials and were shorter for females than for males. With the results from this study, further improvement and validation of human models that incorporate active musculature will be made possible.

  7. The developmental effects of media-ideal internalization and self-objectification processes on adolescents' negative body-feelings, dietary restraint, and binge eating.

    Science.gov (United States)

    Dakanalis, Antonios; Carrà, Giuseppe; Calogero, Rachel; Fida, Roberta; Clerici, Massimo; Zanetti, Maria Assunta; Riva, Giuseppe

    2015-08-01

    Despite accumulated experimental evidence of the negative effects of exposure to media-idealized images, the degree to which body image, and eating related disturbances are caused by media portrayals of gendered beauty ideals remains controversial. On the basis of the most up-to-date meta-analysis of experimental studies indicating that media-idealized images have the most harmful and substantial impact on vulnerable individuals regardless of gender (i.e., "internalizers" and "self-objectifiers"), the current longitudinal study examined the direct and mediated links posited in objectification theory among media-ideal internalization, self-objectification, shame and anxiety surrounding the body and appearance, dietary restraint, and binge eating. Data collected from 685 adolescents aged between 14 and 15 at baseline (47 % males), who were interviewed and completed standardized measures annually over a 3-year period, were analyzed using a structural equation modeling approach. Results indicated that media-ideal internalization predicted later thinking and scrutinizing of one's body from an external observer's standpoint (or self-objectification), which then predicted later negative emotional experiences related to one's body and appearance. In turn, these negative emotional experiences predicted subsequent dietary restraint and binge eating, and each of these core features of eating disorders influenced each other. Differences in the strength of these associations across gender were not observed, and all indirect effects were significant. The study provides valuable information about how the cultural values embodied by gendered beauty ideals negatively influence adolescents' feelings, thoughts and behaviors regarding their own body, and on the complex processes involved in disordered eating. Practical implications are discussed. PMID:25416025

  8. Plasma bile acids show a positive correlation with body mass index and are negatively associated with cognitive restraint of eating in obese patients

    Directory of Open Access Journals (Sweden)

    Philip ePrinz

    2015-06-01

    Full Text Available Bile acids may be involved in the regulation of food intake and energy metabolism. The aim of the study was to investigate the association of plasma bile acids with body mass index (BMI and the possible involvement of circulating bile acids in the modulation of physical activity and eating behavior. Blood was obtained in a group of hospitalized patients with normal weight (BMI 18.5-25 kg/m2, underweight (anorexia nervosa, BMI 50 kg/m2, n=14-15/group and plasma bile acid concentrations assessed. Physical activity and plasma bile acids were measured in a group of patients with anorexia nervosa (BMI 14.6±0.3 kg/m2, n=43. Lastly, in a population of obese patients (BMI 48.5±0.9 kg/m2, n=85, psychometric parameters related to disordered eating and plasma bile acids were assessed. Plasma bile acids showed a positive correlation with BMI (r=0.26, p=0.03 in the population of patients with broad range of BMI (9-85 kg/m2, n=74. No associations were observed between plasma bile acids and different parameters of physical activity in anorexic patients (p>0.05. Plasma bile acids were negatively correlated with cognitive restraint of eating (r=-0.30, p=0.008, while no associations were observed with other psychometric eating behavior-related parameters (p>0.05 in obese patients. In conclusion, these data may point towards a role of bile acids in the regulation of body weight. Since plasma bile acids are negatively correlated with the cognitive restraint of eating in obese patients, this may represent a compensatory adaptation to prevent further overeating.

  9. [Regeneration capacity of skeletal muscle].

    Science.gov (United States)

    Wernig, A

    2003-07-01

    The organotypic stem cell of skeletal muscle has previously been known as satellite cell. They allow muscle fiber growth during ontogenesis, enable fiber hypertrophy and are responsible for the very efficient repair of muscle fibers. This efficient apparatus is to some degree counterbalanced by an enormous use of the satellite cell pool: fiber atrophy probably is accompanied by loss of myonuclei such that every reversal of atrophy is bound to use new myonuclei i.e. satellite cells. How often in life does this occur? Hard to say. Moreover, the potent repair capacity is challenged by an unexpected vulnerability of skeletal muscle fibers: Passive stretching of contracted muscles may cause multiple "microdamage," disruption of contractile elements or tiny areas of true necrosis (focal necrosis). How often does this happen? Well, for many of us at least once per year when we go up and down mountains during vacation time, followed by sour muscles. Others may decide to change his/her (locomotor) behaviour by severe onset of jogging; it may happen that they suffer kidney failure on Monday due to muscle microdamage and the transfer of myoproteins into the serum over weekend. Also 20 minutes of stepping up and down something like a chair will do: There is a remarkable increase in kreatin kinase and other muscle derived proteins which lasts for days and is bound to reflect some muscle damage. How about sportsmen and worker who repeatedly use their muscles in such a way? We don't have answers yet to most of these questions, but considerable amount of information has been collected over the last years both in animal and--less--in human. What is common in all cases of growth and repair is the proliferation of the satellite cells and their consequent incorporation and fusion with the parent fiber. This way focal damage is repaired often without visible reminders. We would run out of satellite cells were they not stem cells: After division one daughter remains a satellite cell

  10. Managing nuclear predominant generating capacity

    International Nuclear Information System (INIS)

    The most common believe, associated with nuclear power plant, leads to the conclusion that it can only operate, as a base load plant. This observation can be reversed, by just looking at large generating capacity, using an important nuclear generation mix. Nuclear plants may certainly load follow and contribute to the grid frequency control. The French example illustrates these possibilities. The reactor control of French units has been customized to accommodate the grid requests. Managing such a large nuclear plant fleet requires to take various actions, ranging from a daily basis to a multi-annual prospective standpoint. The paper describes the various contributions leading to safe, reliable, well accepted and cost competitive nuclear plants in France. The combination of all aspects related to operations, maintenance scheduling, nuclear safety management, are presented. The use of PWR units carries considerable weight in economic terms, with several hundred million francs tied in with outage scheduling every year. This necessitates a global view of the entire generating system which can be mobilized to meet demand. There is considerable interaction between units as, on the one hand, they are competing to satisfy the same need, and, on the other hand, reducing maintenance costs means sharing the necessary resources, and thus a coordinated staggering of outages. In addition, nuclear fuel is an energy reserve which remains in the reactor for 3 or 4 years, with some of the fuel renewed each year. Due to the memory effect, the fuel retains a memory of past use, so that today's choices impact upon the future. A medium-term view of fuel management is also necessary. The coordination systems implemented by EDF aim to control these parameters for the benefit of electricity consumers. (author)

  11. North Dakota Refining Capacity Study

    Energy Technology Data Exchange (ETDEWEB)

    Dennis Hill; Kurt Swenson; Carl Tuura; Jim Simon; Robert Vermette; Gilberto Marcha; Steve Kelly; David Wells; Ed Palmer; Kuo Yu; Tram Nguyen; Juliam Migliavacca

    2011-01-05

    According to a 2008 report issued by the United States Geological Survey, North Dakota and Montana have an estimated 3.0 to 4.3 billion barrels of undiscovered, technically recoverable oil in an area known as the Bakken Formation. With the size and remoteness of the discovery, the question became 'can a business case be made for increasing refining capacity in North Dakota?' And, if so what is the impact to existing players in the region. To answer the question, a study committee comprised of leaders in the region's petroleum industry were brought together to define the scope of the study, hire a consulting firm and oversee the study. The study committee met frequently to provide input on the findings and modify the course of the study, as needed. The study concluded that the Petroleum Area Defense District II (PADD II) has an oversupply of gasoline. With that in mind, a niche market, naphtha, was identified. Naphtha is used as a diluent used for pipelining the bitumen (heavy crude) from Canada to crude markets. The study predicted there will continue to be an increase in the demand for naphtha through 2030. The study estimated the optimal configuration for the refinery at 34,000 barrels per day (BPD) producing 15,000 BPD of naphtha and a 52 percent refinery charge for jet and diesel yield. The financial modeling assumed the sponsor of a refinery would invest its own capital to pay for construction costs. With this assumption, the internal rate of return is 9.2 percent which is not sufficient to attract traditional investment given the risk factor of the project. With that in mind, those interested in pursuing this niche market will need to identify incentives to improve the rate of return.

  12. Dating human cultural capacity using phylogenetic principles.

    Science.gov (United States)

    Lind, J; Lindenfors, P; Ghirlanda, S; Lidén, K; Enquist, M

    2013-01-01

    Humans have genetically based unique abilities making complex culture possible; an assemblage of traits which we term "cultural capacity". The age of this capacity has for long been subject to controversy. We apply phylogenetic principles to date this capacity, integrating evidence from archaeology, genetics, paleoanthropology, and linguistics. We show that cultural capacity is older than the first split in the modern human lineage, and at least 170,000 years old, based on data on hyoid bone morphology, FOXP2 alleles, agreement between genetic and language trees, fire use, burials, and the early appearance of tools comparable to those of modern hunter-gatherers. We cannot exclude that Neanderthals had cultural capacity some 500,000 years ago. A capacity for complex culture, therefore, must have existed before complex culture itself. It may even originated long before. This seeming paradox is resolved by theoretical models suggesting that cultural evolution is exceedingly slow in its initial stages. PMID:23648831

  13. Effective capacity of correlated MISO channels

    KAUST Repository

    Zhong, Caijun

    2011-06-01

    This paper presents an analytical performance investigation of the capacity limits of correlated multiple-input single-output (MISO) channels in the presence of quality-of-service (QoS) requirements. Exact closed-form expression for the effective capacity of correlated MISO channels is derived. In addition, simple expressions are obtained at the asymptotic high and low signal-to-noise ratio (SNR) regimes, which provide insights into the impact of various system parameters on the effective capacity of the system. Also, a complete characterization of the impact of spatial correlation on the effective capacity is provided with the aid of a majorization theory result. The findings suggest that antenna correlation reduce the effective capacity of the channels. Moreover, a stringent QoS requirement causes a significant reduction in the effective capacity but this can be effectively alleviated by increasing the number of antennas. © 2011 IEEE.

  14. Bitstream - Capacity Building for Innovation : Final report

    OpenAIRE

    Söderström, Mikael; Hedestig, Ulf; Fallmyr, Terje; Ellingsen, Kjell; Hegerholm, Hallstein; Klæboe, Geir-Tore

    2014-01-01

    The main objective of the Bitstream project was to create a transnational platform for capacity building and exchange of experiences in the area of innovative business development. This includes capacity building for staff in the public sector in Norway and Sweden. The project deliverables has been to accomplish A virtual and physical transnational platform for capacity building that includes a cross-border exchange of experiences, research and developments in innovative business development....

  15. Absorptive capacity and regional patterns of innovation

    OpenAIRE

    Abreu, Maria; Grinevich, Vadim; Kitson, Michael; Savona, Maria

    2008-01-01

    Executive Summary This paper considers whether differences in absorptive capacity at the firm-level are determinants of regional variations in innovation performance. Differences in firms’ absorptive capacity are also due to sectoral and technological specificities. Both firms’ absorptive capacity and sectoral structure differ widely across regions: this analysis focuses on the former while controlling for the latter aspect in order to evaluate regional differences in firms’ propensity to...

  16. The Determinants of National Innovative Capacity

    OpenAIRE

    Scott Stern; Porter, Michael E.; Jeffrey L. Furman

    2000-01-01

    Motivated by differences in R&D productivity across advanced economies, this paper presents an empirical examination of the determinants of country-level production of international patents. We introduce a novel framework based on the concept of national innovative capacity. National innovative capacity is the ability of a country to produce and commercialize a flow of innovative technology over the long term. National innovative capacity depends on the strength of a nation's common innovatio...

  17. ADAPTIVE CAPACITY OF STUDENTS’ CARDIOVASCULAR SYSTEM

    OpenAIRE

    Arabadzhi Liliya Ivanivna

    2012-01-01

    Data about adaptive capacity of cardiovascular system of 106 students were analyzed. Using the method of R.M. Bayevskiy, current adaptive capacity of students’ organisms was estimated. The number of students with stress adaptation mechanisms significantly increased with their age (from 17 to 23 years). In our opinion, this could be explained by negative impact of urbanization, significant learning overload and lack of physical activity among the students. Dependence of the adaptive capacity...

  18. Channel capacities via $p$-summing norms

    OpenAIRE

    Junge, Marius; Palazuelos Cabezón, Carlos

    2013-01-01

    In this paper we show how the metric theory of tensor products developed by Grothendieck perfectly fits in the study of channel capacities, a central topic in Shannon’s information theory. Furthermore, in the last years Shannon’s theory has been fully generalized to the quantum setting, and revealed qualitatively new phenomena in comparison. In this paper we consider the classical capacity of quantum channels with restricted assisted entanglement. These capacities include the classical capaci...

  19. Institutional Capacity Building for Rural Women's Empowerment

    OpenAIRE

    Rooij, De

    2005-01-01

    Basically, women¿s empowerment is the process (and its outcomes) in which women ¿ individually and collectively- become active, knowledgeable and goal-oriented actors who take and/ or support initiatives to overcoming gender inequalities. Hence, women¿s empowerment refers to a strategy to achieve gender equality as well as to the inherent capacity building processes. Institutional capacity aimed at women¿s empowerment is not a clearly defined concept. Yet, effective capacity building requires...

  20. Statistical measures for workload capacity analysis.

    Science.gov (United States)

    Houpt, Joseph W; Townsend, James T

    2012-10-01

    A critical component of how we understand a mental process is given by measuring the effect of varying the workload. The capacity coefficient (Townsend & Nozawa, 1995; Townsend & Wenger, 2004) is a measure on response times for quantifying changes in performance due to workload. Despite its precise mathematical foundation, until now rigorous statistical tests have been lacking. In this paper, we demonstrate statistical properties of the components of the capacity measure and propose a significance test for comparing the capacity coefficient to a baseline measure or two capacity coefficients to each other. PMID:23175582

  1. Emergent biosynthetic capacity in simple microbial communities.

    Directory of Open Access Journals (Sweden)

    Hsuan-Chao Chiu

    2014-07-01

    Full Text Available Microbes have an astonishing capacity to transform their environments. Yet, the metabolic capacity of a single species is limited and the vast majority of microorganisms form complex communities and join forces to exhibit capabilities far exceeding those achieved by any single species. Such enhanced metabolic capacities represent a promising route to many medical, environmental, and industrial applications and call for the development of a predictive, systems-level understanding of synergistic microbial capacity. Here we present a comprehensive computational framework, integrating high-quality metabolic models of multiple species, temporal dynamics, and flux variability analysis, to study the metabolic capacity and dynamics of simple two-species microbial ecosystems. We specifically focus on detecting emergent biosynthetic capacity--instances in which a community growing on some medium produces and secretes metabolites that are not secreted by any member species when growing in isolation on that same medium. Using this framework to model a large collection of two-species communities on multiple media, we demonstrate that emergent biosynthetic capacity is highly prevalent. We identify commonly observed emergent metabolites and metabolic reprogramming patterns, characterizing typical mechanisms of emergent capacity. We further find that emergent secretion tends to occur in two waves, the first as soon as the two organisms are introduced, and the second when the medium is depleted and nutrients become limited. Finally, aiming to identify global community determinants of emergent capacity, we find a marked association between the level of emergent biosynthetic capacity and the functional/phylogenetic distance between community members. Specifically, we demonstrate a "Goldilocks" principle, where high levels of emergent capacity are observed when the species comprising the community are functionally neither too close, nor too distant. Taken together

  2. A Capacity Supply Model for Virtualized Servers

    Directory of Open Access Journals (Sweden)

    Alexander PINNOW

    2009-01-01

    Full Text Available This paper deals with determining the capacity supply for virtualized servers. First, a server is modeled as a queue based on a Markov chain. Then, the effect of server virtualization on the capacity supply will be analyzed with the distribution function of the server load.

  3. Economic Development Capacity amongst Small Rural Communities.

    Science.gov (United States)

    Keane, Michael J.

    1990-01-01

    Examines indigenous capacity for local community development. Examines new economic development initiatives by communities, nature of relationships between local and larger economies, and how relationships affect local capacity for new economic activities. Discusses benefits of spatial framework in rural development and planning. (TES)

  4. Knowledge management capacity and innovation performance

    OpenAIRE

    Niloufar Asgarian

    2012-01-01

    The aim of this paper is to study relationship between knowledge management capacity and innovation performance. Knowledge management capacity includes knowledge sharing, knowledge application, and knowledge acquisition. For innovation performance, author considers the most important indicators including administrative innovation, product innovation, and process innovation. According to research model, 9 hypotheses are developed and the results show that there is not any positive relationship...

  5. On entanglement-assisted classical capacity

    Science.gov (United States)

    Holevo, A. S.

    2002-09-01

    We give a modified proof of the recent result of C. H. Bennett, P. W. Shor, J. A. Smolin, and A. V. Thapliyal concerning entanglement-assisted classical capacity of a quantum channel and discuss the relation between entanglement-assisted and unassisted classical capacities.

  6. The Heat Capacity of Ideal Gases

    Science.gov (United States)

    Scott, Robert L.

    2006-01-01

    The heat capacity of an ideal gas has been shown to be calculable directly by statistical mechanics if the energies of the quantum states are known. However, unless one makes careful calculations, it is not easy for a student to understand the qualitative results. Why there are maxima (and occasionally minima) in heat capacity-temperature curves…

  7. Transience and capacity of minimal submanifolds

    DEFF Research Database (Denmark)

    Markvorsen, Steen; Palmer, V.

    2003-01-01

    We prove explicit lower bounds for the capacity of annular domains of minimal submanifolds P-m in ambient Riemannian spaces N-n with sectional curvatures bounded from above. We characterize the situations in which the lower bounds for the capacity are actually attained. Furthermore we apply these...

  8. On Quantum Capacity and its Bound

    OpenAIRE

    Ohya, Masanori; Volovich, Igor V.

    2004-01-01

    The quantum capacity of a pure quantum channel and that of classical-quantum-classical channel are discussed in detail based on the fully quantum mechanical mutual entropy. It is proved that the quantum capacity generalizes the so-called Holevo bound.

  9. Capacitated Dynamic Lot Sizing with Capacity Acquisition

    DEFF Research Database (Denmark)

    Li, Hongyan; Meissner, Joern

    a model which combines the complexity of time-varying demand and cost functions and that of scale economies arising from dynamic lot-sizing costs with the purchase cost of capacity. We propose a heuristic algorithm that runs in polynomial time to determine a good capacity level and corresponding lot...

  10. Capacitated dynamic lot sizing with capacity acquisition

    DEFF Research Database (Denmark)

    Li, Hongyan; Meissner, Joern

    2011-01-01

    . For this situation, we develop a model which combines the complexity of time-varying demand and cost functions and of scale economies arising from dynamic lot-sizing costs with the purchase cost of capacity. We propose a heuristic algorithm that runs in polynomial time to determine a good capacity level...

  11. Time to reassess capacity-building partnerships

    Directory of Open Access Journals (Sweden)

    Brooke Lauten

    2007-07-01

    Full Text Available Since 2001 the Watchlist on Children and Armed Conflict has worked with local civil society organisations, child protection networks and grassroots organisations to build capacity to monitor and respond to abuses of children’s rights. Through our capacity-building partnerships, we work to shift the power structure that defines the roles of national and international NGO's in humanitarian programming.

  12. Enriching Absorptive Capacity through Social Interaction

    NARCIS (Netherlands)

    Hotho, Jasper J.; Becker-Ritterspach, Florian; Saka-Helmhout, Ayse

    2012-01-01

    Absorptive capacity is frequently highlighted as a key determinant of knowledge transfer within multinational enterprises. But how individual behaviour translates into absorptive capacity at the subsidiary level, and how this is contingent on subsidiaries' social context, remains under-addressed. Th

  13. Breeding for feed intake capacity in pigs

    NARCIS (Netherlands)

    Eissen, J.J.

    2000-01-01

    This thesis deals with feed intake capacity of pigs. By selection, breeding organizations try to achieve genetic improvement in production and reproduction efficiency. Future genetic improvement may become constrained by a limited feed intake capacity of growing pigs and lactating sows, respectively

  14. Spatial Information Capacity of Compound Eyes

    NARCIS (Netherlands)

    Snyder, Allan W.; Stavenga, Doekele G.; Laughlin, Simon B.

    1977-01-01

    The capacity of the compound eye to perceive its spatial environment is quantified by determining the number of different pictures that can be reconstructed by its array of retinula cells. We can then decide on the best compromise between an animal's capacity for fine detail and contrast sensitivity

  15. Dispelling the magic : Towards memory without capacity

    NARCIS (Netherlands)

    Taatgen, NA

    2001-01-01

    The limited capacity for unrelated things is a fact that needs to be explained by a general theory of memory; rather than being itself used as a means of explaining data. A pure storage capacity is therefore not the right assumption for memory research. Instead an explanation is needed of how capaci

  16. Wind power fluctuations impact on capacity credit

    International Nuclear Information System (INIS)

    It is generally recognized that at small wind energy penetration levels, the capacity credit of many widely dispersed wind turbines is about equal to their average power output. In systems with few wind turbines, however, wind power fluctuations are not averaging each other out, and the capacity credit must be reduced. A methodology for estimating the capacity credit taking into consideration the wind power fluctuations is described. The methodology utilizes the commonly applied loss of load expectation index for estimating the capacity credit. Calculations are made and presented for a number of power system configurations and wind power penetration levels. It is concluded that the described methodology gives a consistent approach for determining the capacity credit for small and large systems with a few or many dispersed wind turbines. (Author)

  17. Enriching Absorptive Capacity Through Social Interaction

    DEFF Research Database (Denmark)

    Hotho, Jasper Jaap; Becker-Ritterspach, Florian; Saka-Helmhout, Ayse

    Absorptive capacity is frequently highlighted as a key determinant of knowledge transfer within MNEs. But how individual behaviour translates to absorptive capacity at the subsidiary level, and exactly how this is contingent on subsidiaries’ social context, remains under-addressed. This not only...... their organization’s capacity to put new knowledge to use. To address this shortcoming we conduct an in-depth comparative case study of a headquarters-initiated knowledge transfer initiative at two subsidiaries of the same MNE. The findings demonstrate that social interaction is a key requirement for subsidiary...... absorptive capacity as it enables employees to participate in the transformation of new knowledge to the local context. Second, the findings illustrate how organizational conditions at the subsidiary level can impact subsidiary absorptive capacity by enabling or constraining local interaction patterns...

  18. Algorithm of capacity expansion on networks optimization

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The paper points out the relationship between the bottleneck and the minimum cutset of the network, and presents a capacity expansion algorithm of network optimization to solve the network bottleneck problem. The complexity of the algorithm is also analyzed. As required by the algorithm, some virtual sources are imported through the whole positive direction subsection in the network, in which a certain capacity value is given. Simultaneously, a corresponding capacity-expanded network is constructed to search all minimum cutsets. For a given maximum flow value of the network, the authors found an adjustment value of each minimum cutset arc's group with gradually reverse calculation and marked out the feasible flow on the capacity-extended networks again with the adjustment value increasing. All this has been done repeatedly until the original topology structure is resumed. So the algorithm can increase the capacity of networks effectively and solve the bottleneck problem of networks.

  19. The quantum capacity with symmetric side channels

    CERN Document Server

    Smith, G; Winter, A; Smith, Graeme; Smolin, John A.; Winter, Andreas

    2006-01-01

    We present an upper bound for the quantum channel capacity that is both additive and convex. Our bound can be interpreted as the capacity of a channel for high-fidelity communication when assisted by the family of all channels mapping symmetrically to their output and environment. The bound seems to be quite tight, and for degradable quantum channels it coincides with the unassisted channel capacity. Using this symmetric side channel capacity, we find new upper bounds on the capacity of the depolarizing channel. We also briefly indicate an analogous notion for distilling entanglement using the same class of (one-way) channels, yielding one of the few genuinely 1-LOCC monotonic entanglement measures.

  20. Secrecy Capacity over Correlated Ergodic Fading Channel

    CERN Document Server

    Jeon, Hyoungsuk; Kim, Minki; Lee, Hyuckjae; Ha, Jeongseok

    2008-01-01

    We investigate the secrecy capacity of an ergodic fading wiretap channel in which the main channel is correlated with the eavesdropper channel. In this study, the full Channel State Information (CSI) is assumed, and thus the transmitter knows the channel gains of the legitimate receiver and the eavesdropper. By analyzing the resulting secrecy capacity we quantify the loss of the secrecy capacity due to the correlation. In addition, we study the asymptotic behavior of the secrecy capacity as Signal-to-Noise Ratio (SNR) tends to infinity. The capacity of an ordinary fading channel logarithmically increases with SNR. On the contrary, the secrecy capacity converges into a limit which can be an upper bound on the secrecy capacity over the fading wiretap channel. We find a closed form of the upper bound for the correlated Rayleigh wiretap channel which also includes the independent case as a special one. Our work shows that the upper bound is determined by only two channel parameters; the correlation coefficient an...

  1. Enriching Absorptive Capacity through Social Interaction

    DEFF Research Database (Denmark)

    Hotho, Jasper J.; Saka-Helmhout, Ayse; Becker-Ritterspach, Florian

    2012-01-01

    Absorptive capacity is frequently highlighted as a key determinant of knowledge transfer within multinational enterprises. But how individual behaviour translates into absorptive capacity at the subsidiary level, and how this is contingent on subsidiaries' social context, remains under-addressed.......Absorptive capacity is frequently highlighted as a key determinant of knowledge transfer within multinational enterprises. But how individual behaviour translates into absorptive capacity at the subsidiary level, and how this is contingent on subsidiaries' social context, remains under...... their organization's capacity to put new knowledge to use. To address this shortcoming we conduct an in-depth comparative case study of a headquarters-initiated knowledge transfer at two subsidiaries of the same multinational enterprise. The findings demonstrate that social interaction is a prerequisite...... for subsidiary absorptive capacity as it enables employees to participate in the transformation of new knowledge to the local context and the development of local applications. The findings also illustrate how organizational conditions at the subsidiary level can impact subsidiary absorptive capacity by enabling...

  2. Hanford Waste Vitrification Plant capacity increase options

    International Nuclear Information System (INIS)

    Studies are being conducted by the Hanford Waste Vitrification Plant (HWVP) Project on ways to increase the waste processing capacity within the current Vitrification Building structural design. The Phase 1 study on remote systems concepts identification and extent of capacity increase was completed. The study concluded that the HWVP capacity could be increased to four times the current capacity with minor design adjustments to the fixed facility design, and the required design changes would not impact the current footprint of the vitrification building. A further increase in production capacity may be achievable but would require some technology development, verification testing, and a more systematic and extensive engineering evaluation. The primary changes included a single advance melter with a higher capacity, new evaporative feed tank, offgas quench collection tank, ejector venturi scrubbers, and additional inner canister closure station,a smear test station, a new close- coupled analytical facility, waste hold capacity of 400,000 gallon, the ability to concentrate out-of-plant HWVP feed to 90 g/L waste oxide concentration, and limited changes to the current base slab construction package

  3. Photovoltaics effective capacity: Interim final report 2

    Energy Technology Data Exchange (ETDEWEB)

    Perez, R.; Seals, R. [State Univ. of New York, Albany, NY (United States). Atmospheric Sciences Research Center

    1997-11-01

    The authors provide solid evidence, based on more than 8 million data points, that regional photovoltaic (PV) effective capacity is largely unrelated to the region`s solar resource. They confirm, however, that effective capacity is strongly related to load-shape characteristics. The load-shape effective-capacity relationship appears to be valid for end-use loads as small as 100 kW, except possibly in the case of electrically heated buildings. This relationship was used as a tool to produce a US map of PV`s effective capacity. The regions of highest effective capacities include (1) the central US from the northern Great Plains to the metropolitan areas of Chicago and Detroit, down to the lower Mississippi Valley, (2) California and western Arizona, and (3) the northeast metropolitan corridor. The features of this map are considerably different from the traditional solar resource maps. They tend to reflect the socio-economic and climatic factors that indirectly drive PV`s effective capacity: e.g., commercial air-conditioning, little use of electric heat, and strong summer heat waves. The map provides a new and significant insight to a comprehensive valuation of the PV resource. The authors assembled preliminary evidence showing that end-use load type may be related to PV`s effective capacity. Highest effective capacities were found for (nonelectrically heated) office buildings, followed by hospitals. Lowest capacities were found for airports and residences. Many more data points are needed, however, to ascertain and characterize these preliminary findings.

  4. Simultaneous Minimization of Capacity and Conflict Misses

    Institute of Scientific and Technical Information of China (English)

    Zhiyuan Li

    2007-01-01

    Loop tiling (or loop blocking) is a well-known loop transformation to improve temporal locality in nested loops which perform matrix computations. When targeting caches that have low associativities, one of the key challenges for loop tiling is to simultaneously minimize capacity misses and conflict misses. This paper analyzes the effect of the tile size and the array-dimension size on capacity misses and conflict misses. The analysis supports the approach of combining tile-size selection (to minimize capacity misses) with array padding (to minimize conflict misses).

  5. Capacity management a practitioner guide : best practice

    CERN Document Server

    Grummit, Adam

    2010-01-01

    Capacity Management is described in most key ITSM frameworks: ITIL, ISO 20000 Microsoft Operations Framework (MOF) and the Application Service Library (ASL) all note the importance of Capacity Management. This major title meets the need for an in-depth practical guide to this critical process. Written and reviewed by some of the world?s most respected experts in this field it shows how Capacity Management best practice can support provision of a consistent, acceptable service level at a known and controlled cost. Practical advice covers the essential control of two balances: Supply versus dem

  6. CO2 Absorbing Capacity of MEA

    OpenAIRE

    José I Huertas; Gomez, Martin D.; Nicolas Giraldo; Jessica Garzón

    2015-01-01

    We describe the use of a gas bubbler apparatus in which the gas phase is bubbled into a fixed amount of absorbent under standard conditions as a uniform procedure for determining the absorption capacity of solvents. The method was systematically applied to determine the CO2 absorbing capacity of MEA (Ac) at several aqueous MEA (β) and gas-phase CO2 concentrations. Ac approached the nominal CO2 absorbing capacity of MEA (720 g CO2/kg MEA) at very low β levels, increasing from 447.9±18.1 to 581...

  7. Information Capacity of Energy Harvesting Sensor Nodes

    CERN Document Server

    Rajesh, R

    2010-01-01

    Sensor nodes with energy harvesting sources are gaining popularity due to their ability to improve the network life time and are becoming a preferred choice supporting 'green communication'. We study such a sensor node with an energy harvesting source and compare various architectures by which the harvested energy is used. We find its Shannon capacity when it is transmitting its observations over an AWGN channel and show that the capacity achieving energy management policy is the same as the throughput optimal policy. We also obtain the capacity for the system with energy inefficiencies in storage and an achievable rate when energy conserving sleep-wake modes are supported.

  8. Capacity choices in liberalised electricity markets

    International Nuclear Information System (INIS)

    This paper addresses the issue of investment in electricity generation in the context of a liberalised market. We use the main results derived from a theoretical model where firms invest strategically to simulate the Spanish electricity system with real-world data. Our results indicate that, under reasonable parameter constellations regarding the number of agents, the level of capacity resulting from private decisions falls well short of the social optimum. Last, we show that two regulatory mechanisms that have been used to generate additional incentives for private agents to install capacity (capacity payment and price-adder) are ineffective and/or prohibitively costly. (author)

  9. Effect of Beta vulgaris Linn. Leaves Extract on Anxiety- and Depressive-like Behavior and Oxidative Stress in Mice after Acute Restraint Stress

    Science.gov (United States)

    Sulakhiya, Kunjbihari; Patel, Vikas Kumar; Saxena, Rahul; Dashore, Jagrati; Srivastava, Amit Kumar; Rathore, Manoj

    2016-01-01

    Background: Stress plays a significant role in the pathogenesis of neuropsychiatric disorders such as anxiety and depression. Beta vulgaris is commonly known as “beet root” possessing antioxidant, anticancer, hepatoprotective, nephroprotective, wound healing, and anti-inflammatory properties. Objective: To study the protective effect of Beta vulgaris Linn. ethanolic extract (BVEE) of leaves against acute restraint stress (ARS)-induced anxiety- and depressive-like behavior and oxidative stress in mice. Materials and Methods: Mice (n = 6) were pretreated with BVEE (100 and 200 mg/kg, p. o.) for 7 days and subjected to ARS for 6 h to induce behavioral and biochemical changes. Anxiety- and depressive-like behavior were measured by using different behavioral paradigms such as open field test (OFT), elevated plus maze (EPM), forced swim test (FST), and tail suspension test (TST) 40 min postARS. Brain homogenate was used to analyze oxidative stress parameters, that is, malondialdehyde (MDA) and reduced glutathione (GSH) level. Results: BVEE pretreatment significantly (P < 0.05) reversed the ARS-induced reduction in EPM parameters, that is, percentage entries and time spent in open arms and in OFT parameters, that is, line crossings, and rearings in mice. ARS-induced increase in the immobility time in FST and TST was attenuated significantly (P < 0.05) by BVEE pretreatment at both the dosage. An increase in MDA and depletion of GSH level postARS was prevented significantly (P < 0.05) with BVEE pretreatment at both the dosage (100 and 200 mg/kg). Conclusion: BVEE exhibits anxiolytic and antidepressant activity in stressed mice along with good antioxidant property suggesting its therapeutic potential in the treatment of stress-related psychiatric disorders. SUMMARY Stress plays major role in the pathogenesis of anxiety and depressionARS-induced anxiety- and depressive-like behavior through oxidative damage in miceBVEE pretreatment reversed ARS-induced behavioral changes

  10. Effect of the Head Restraint Properties on Head-neck Kinematics in Low Speed Rear-end Impacts%汽车低速追尾碰撞中人体颈部伤害及保护系统研究

    Institute of Scientific and Technical Information of China (English)

    乔维高; 商博

    2011-01-01

    在MADYMO软件中使用BioRID Ⅱ后碰撞假人建立追尾碰撞模型,分析了头枕位置和倾角参数对汽车发生追尾碰撞时头颈部动力学的影响,并使用颈部损伤准则值NIC和Nkm来评估颈部损伤的风险.仿真结果表明这些因素对颈部的动力学响应有着重要影响,高而且靠近头部,并且有适当增大倾角的头枕,有助于减小颈部的损伤.%Head restraint plays a very important part in protecting the occupants during the rear impact. The present study investigated the effects of the position, tilt angle of the head restraint on the biomechanical responses and related injury measures of the neck in a rear-end impact. A series of simulated rear-end impacts were conducted by applying a rear-end impact model, which is developed in the MADYMO package by using the BioRID II dummy. Then, the neck injury criterion (NIC) and JV\\-km were utilized to assess the likelihood of injury. The results show that modifying the head restraint may influence the head-neck kinematics to a great extent. It is possible to reduce the neck injury risk by positioning the head restraint higher and closer to the head, and with a proper larger tilt angle.

  11. The Fourier Pseudospectral Method With Restraint Operator for Burgers Equation%求解Burger's方程带限制算子的傅立叶拟谱方法

    Institute of Scientific and Technical Information of China (English)

    Abdur Rashid; Ghulam Mustafa

    2003-01-01

    采用带限制算子的傅立叶拟谱方法近似求解了Burger's方程,分别证明了它的(Burger's方程)一般化的稳定性和收敛性,并获得了数值结果.%A Fourier pseudospectral approximation with a restraint operator is developed for solving Burger's equation. The generalized stability and convergence are proved respectively. The numerical results are also presented.

  12. Heat Capacity Mapping Mission: 1978-1980

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — NASA's Heat Capacity Mapping Mission (HCMM) project collected Earth data in the visible and thermal bands between April 1978 and September 1980. This was an...

  13. Modified MIMO Cube for Enhanced Channel Capacity

    Directory of Open Access Journals (Sweden)

    Lajos Nagy

    2012-01-01

    Full Text Available This paper deals with the optimization of MIMO antenna elements' position in modified MIMO cube for getting maximal channel capacity in indoor environment. The dependence of the channel capacity on the antenna orientation was analyzed by simulations. We have also examined the effect of the frequency dependence of the antenna system (in case of conjugate matching and nonconjugate matching for the channel capacity. Based on the simulation results in the created and measured antenna system, the antennas were at a right angle to each other. At the two chosen different structures, we measured the antenna parameters and the channel capacity. In this paper, we present the results of the measurements which clearly confirm our simulations. We will point out the differences between the two antenna structures.

  14. Capacity-speed relationships in prefrontal cortex.

    Directory of Open Access Journals (Sweden)

    Vivek Prabhakaran

    Full Text Available Working memory (WM capacity and WM processing speed are simple cognitive measures that underlie human performance in complex processes such as reasoning and language comprehension. These cognitive measures have shown to be interrelated in behavioral studies, yet the neural mechanism behind this interdependence has not been elucidated. We have carried out two functional MRI studies to separately identify brain regions involved in capacity and speed. Experiment 1, using a block-design WM verbal task, identified increased WM capacity with increased activity in right prefrontal regions, and Experiment 2, using a single-trial WM verbal task, identified increased WM processing speed with increased activity in similar regions. Our results suggest that right prefrontal areas may be a common region interlinking these two cognitive measures. Moreover, an overlap analysis with regions associated with binding or chunking suggest that this strategic memory consolidation process may be the mechanism interlinking WM capacity and WM speed.

  15. Hawaii Large Capacity Cesspools (LCC) Compliant

    Data.gov (United States)

    U.S. Environmental Protection Agency — LCC Compliant: Large Capacity Cesspools that have been properly abandoned or converted to a seepage pit that is associated with a State approved IWS. These LCCs are...

  16. Capacity Bounds for Parallel Optical Wireless Channels

    KAUST Repository

    Chaaban, Anas

    2016-01-01

    A system consisting of parallel optical wireless channels with a total average intensity constraint is studied. Capacity upper and lower bounds for this system are derived. Under perfect channel-state information at the transmitter (CSIT), the bounds have to be optimized with respect to the power allocation over the parallel channels. The optimization of the lower bound is non-convex, however, the KKT conditions can be used to find a list of possible solutions one of which is optimal. The optimal solution can then be found by an exhaustive search algorithm, which is computationally expensive. To overcome this, we propose low-complexity power allocation algorithms which are nearly optimal. The optimized capacity lower bound nearly coincides with the capacity at high SNR. Without CSIT, our capacity bounds lead to upper and lower bounds on the outage probability. The outage probability bounds meet at high SNR. The system with average and peak intensity constraints is also discussed.

  17. Ant Colony Optimization for Capacity Problems

    Directory of Open Access Journals (Sweden)

    Tad Gonsalves

    2015-01-01

    Full Text Available This paper deals with the optimization of the capac ity of a terminal railway station using the Ant Colony Optimization algorithm. The capacity of the terminal station is defined as the number of trains that depart from the station in un it interval of time. The railway capacity optimization problem is framed as a typical symmetr ical Travelling Salesman Problem (TSP, with the TSP nodes representing the train arrival / departure events and the TSP total cost representing the total time-interval of the schedul e. The application problem is then optimized using the ACO algorithm. The simulation experiments validate the formulation of the railway capacity problem as a TSP and the ACO algorithm pro duces optimal solutions superior to those produced by the domain experts.

  18. DIFFUSION CAPACITY IN HEART-TRANSPLANT RECIPIENTS

    NARCIS (Netherlands)

    GROEN, HJM; BOGAARD, JM; BALK, AHMM; KHO, SG; HOP, WCJ; HILVERING, C

    1992-01-01

    Preoperative diffusion capacity per liter alveolar volume (Kco) in cardiac transplant recipients with an intrinsic normal lung is within the normal range. In the first postoperative year, Kco showed a significant mean decrease of 12 percent (p

  19. Capacity of Intelligent Underlay and Overlay Network

    DEFF Research Database (Denmark)

    Ling, Yim; Elling, Jan; Nielsen, Thomas Toftegaard

    1996-01-01

    This paper suggests a method of dimensioning the cell configuration of radio sites in a cellular network using the intelligent overlay and underlay (IOU) technique. The traffic capacity has been analysed by means of a teletraffic model, which is developed based on the classical theory of overflow...... traffic. The formulas of the model have been implemented with the use of MatLab. To verify the model, measurement methods have been developed to collect the teletraffic information in a real-live GSM network. The measured data indicates that the teletraffic model describes the capacity with high accuracy...... and therefore can be used to dimension the network. The model shows that the increase of capacity for a GSM network with 34 frequencies is about 30%. Further capacity enhancement can be achieved by intelligent frequency planning method which is currently being developed...

  20. Innovation capacity in the public sector

    DEFF Research Database (Denmark)

    Lewis, Jenny M; Ricard, Lykke Margot

    2015-01-01

    This article examines the innovation capacity of municipal governments by examining their innovation environments – governance structures, social networks and leadership qualities. An empirical study of this has been recently completed through a survey of politicians and senior administrators...

  1. Heat Capacity of Hydrous Silicate Melts

    Science.gov (United States)

    Robert, G.; Whittington, A. G.; Stechern, A.; Behrens, H.

    2015-12-01

    We determined the heat capacities of four series of glasses and liquids of basaltic and basaltic andesite compositions including two natural remelts from Fuego volcano, Guatemala, and two Fe-free analogs. The samples are low-alkali, Ca- and Mg-rich aluminosilicates with non-bridging oxygen to tetrahedrally-coordinated cation ratios (NBO/T) ranging between 0.33 and 0.67. Differential scanning calorimetry measurements were performed at atmospheric pressure between room temperature and ≈100 K above the glass transition for hydrous samples and up to ≈1800 K for dry samples. The water contents investigated range up to 5.34 wt.% (16.4 mol%). Water does not measurably affect the heat capacity of glasses (T capacity, which generally gets larger with increasing water content and with decreasing polymerization. The onset of the glass transition in hydrous samples also occurs below the Dulong-Petit limit of 3R/g atom. We see little change in liquid heat capacity with increasing water content; hydrous liquid heat capacities are within 3-6% of the dry liquid, at low temperatures just above the glass transition. However, dry liquids show a decrease in heat capacity with increasing temperature above the glass transition, from supercooled to superliquidus temperatures. Liquid heat capacity values just above the glass transition range between 95-100 J/mol K, whereas liquid heat capacity values at superliquidus temperatures are between 85-91 J/mol K. Comparison with other studies of the heat capacity of hydrous glasses and liquids shows that the liquid heat capacity of strongly depolymerized samples (NBO/T ≥ 0.8) increases with increasing water content, whereas depolymerized samples (0.4 ≤ NBO/T ≤ 0.8) or polymerized samples (NBO/T ≤ 0.4) generally show little change or a moderate decrease in liquid heat capacity with increasing water content.

  2. An experiment on strategic capacity reduction

    OpenAIRE

    Mikhael Shor

    2008-01-01

    A firm may strategically decrease capacity to gain bargaining power over its suppliers. Equilibrium models of competition imply that the incentive to reduce capacity to gain buyer power is small because the buyer captures all available surplus by excluding even a single supplier. However, these models can rest on behaviorally untenable actions prescribed to suppliers in equilibrium. In this paper, we test this theory using a laboratory experiment in which subjects compete to supply a single f...

  3. Visual Working Memory Capacity and Proactive Interference

    OpenAIRE

    Hartshorne, Joshua K.

    2008-01-01

    BACKGROUND: Visual working memory capacity is extremely limited and appears to be relatively immune to practice effects or the use of explicit strategies. The recent discovery that visual working memory tasks, like verbal working memory tasks, are subject to proactive interference, coupled with the fact that typical visual working memory tasks are particularly conducive to proactive interference, suggests that visual working memory capacity may be systematically under-estimated. METHODOLOGY/P...

  4. Statistical measures for workload capacity analysis

    OpenAIRE

    Houpt, Joseph W.; Townsend, James T.

    2012-01-01

    A critical component of how we understand a mental process is given by measuring the effect of varying the workload. The capacity coefficient (Townsend & Nozawa, 1995; Townsend & Wenger, 2004) is a measure on response times for quantifying changes in performance due to workload. Despite its precise mathematical foundation, until now rigorous statistical tests have been lacking. In this paper, we demonstrate statistical properties of the components of the capacity measure and propose a signifi...

  5. Robust solutions of Uncertain Capacity inventory control

    Institute of Scientific and Technical Information of China (English)

    Yajing Li

    2013-01-01

    This paper analyzes the uncertainties of air cargo and applies revenue management to solve the problem of air cargo capacity control.A robust capacity al ocation model for a multiple-leg with multiple shipment types is established,which describe uncertainty of these parameters as a number of discrete scenarios,and obtain the optimal al ocation with Mutation Particle Swarm Optimization.Simulation experiments show that this method can balance uncertainty of the model effectively and accord with actual situation.

  6. Peaking Capacity in Restructured Power Systems

    OpenAIRE

    Doorman, Gerard

    2000-01-01

    The theme of this thesis is the supply of capacity during peak demand in restructured power systems. There are a number of reasons why there is uncertainty about whether an enegyonly electricity market (where generators are only paid for the energy produced) is able to ensure uninterrupted supply during peak load conditions.Much of the public debate in Europe has been about the present surplus generation capacity. However, in a truly competitive environment, it is hard to believe that seldom ...

  7. Understanding Collaborative capacity in an ICT context

    DEFF Research Database (Denmark)

    Rai, Sudhanshu

    In this paper my endeavor is to explore the meaning and implication of collaberation within a dynamic frame which I refer to a capacity. First I review the collaboration literature from an innovation perspective and then develop a framework that enables me to engage with the data we collected dur...... this paper discussing the new insight on collaborative capacity (CC) of firms and their implications for ICT collaboration and firm innovativness....

  8. The Capacity, Capability and Competency Strategy

    OpenAIRE

    Timms, Janice; Clark, Richard A.

    2008-01-01

    In the beef industry, as in many agricultural industries in Australia, there is a wealth of high quality capacity building available in topics such as animal breeding, nutrition, grazing land management, record keeping, property planning etc. However there are very few capacity building opportunities targeting (1) the higher level knowledge and skills needed to achieve both rapid and sustainable improvement and innovation, and (2) the knowledge and skills needed to lead and manage sustainable...

  9. Expandability, Reversibility, and Optimal Capacity Choice

    OpenAIRE

    Dixit, Avinash K; Robert S. Pindyck

    1998-01-01

    We develop continuous-time models of capacity choice when demand fluctuates stochastically, and the firm's opportunities to expand or contract are limited. Specifically consider costs of investing or disinvesting that vary with time, or with the amount of capacity already installed. The firm's limited opportunities to expand or contract create call and put options on incremental units of capital; we show how the values of these options affect the firm's investment decisions.

  10. Evaluation of the anaerobe effort capacity

    OpenAIRE

    Anca M. Ionescu

    2008-01-01

    This article aims at presenting the main methods by which can be evaluated the effort anaerobe capacity, as well as their rolein conducting the physical training, depending on the performance level, sportsman’s preparation level, training stage, age andsex; depending on the above-mentioned criteria, are recommended certain tests, related mainly to the specificity (intensity,duration) of the practiced effort. Also, the concomitant appreciation of the aerobe capacity can direct us in evaluation...

  11. ROMANIAN ADMINISTRATIVE CAPACITY OF EUROPEAN FUNDS ABSOBTION

    OpenAIRE

    Irina Bosie; Andrei Puica

    2011-01-01

    The capacity to absorb European funds is part of a state complex integrated admninistrative capacity, a component of a state as a whole. The analysis in this article starts from the theoretical development by studying the reports made by the Romanian Government, correlated with the European Union reports on funds and Romanian legislation. This analysis of the EU's structural funds, highlights the importance of accessing them and the degree to which Romania and member countries benefits of inc...

  12. On entanglement-assisted classical capacity

    CERN Document Server

    Holevo, A S

    2001-01-01

    This paper is essentially a lecture from the author's course on quantum information theory, which is devoted to the result of C. H. Bennett, P. W. Shor, J. A. Smolin and A. V. Thapliyal (quant-ph/0106052) concerning entanglement-assisted classical capacity of a quantum channel. A modified proof of this result is given and relation between entanglement-assisted and unassisted classical capacities is discussed.

  13. The heat capacity of titanium disilicide

    Science.gov (United States)

    Sylla, W. K.; Stillman, S. E.; Sabella, M. S.; Cotts, E. J.

    1994-01-01

    The heat capacity of TiSi2 has been measured in the temperature range 105-500 K. The heat capacity of TiSi2 varies monotonically between temperatures of 100 and 500 K with a reference value of 22.0 +/- 0.2 J/g atom K at 298.15 K. Based upon our heat capacity data, the standard molar entropy of TiSi2 at 298.15 K estimated to be 22.2 +/- 0.8 J/g atom K. Our data support estimates of the higher temperature heat capacity of TiSi2 based upon previously measured heat capacities of different, but similar, substances. A number of TiSi2 samples were prepared by rapidly quenching (greater than 10(exp 5) K/s) from the melt. The structure and the measured heat capacity of these samples were similar to those of well annealed samples, underscoring the thermal stability of this material.

  14. The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex

    Directory of Open Access Journals (Sweden)

    M. M. Menezes

    2013-01-01

    Full Text Available Metabotropic glutamate 2/3 (mGlu2/3 receptors have emerged as potential therapeutic targets due to the ability of mGlu2/3 receptor agonists to modulate excitatory transmission at specific synapses. LY354740 and LY379268 are selective and potent mGlu2/3 receptor agonists that show both anxiolytic- and antipsychotic-like effects in animal models. We compared the efficacy of LY354740 and LY379268 in attenuating restraint-stress-induced expression of the immediate early gene c-Fos in the rat prelimbic (PrL and infralimbic (IL cortex. LY354740 (10 and 30 mg/kg, i.p. showed statistically significant and dose-related attenuation of stress-induced increase in c-Fos expression, in the rat cortex. By contrast, LY379268 had no effect on restraint-stress-induced c-Fos upregulation (0.3–10 mg/kg, i.p.. Because both compounds inhibit serotonin 2A receptor (5-HT2AR-induced c-Fos expression, we hypothesize that LY354740 and LY379268 have different in vivo properties and that 5-HT2AR activation and restraint stress induce c-Fos through distinct mechanisms.

  15. 急、慢性束缚应激对小鼠情绪和学习记忆能力的不同影响%Different effects on emotion and cognition induced by acute restraint stress and chronic restraint stress in mice

    Institute of Scientific and Technical Information of China (English)

    周科成; 佳娜提; 吴黄辉; 王锋; 胡伟; 寇俊萍

    2013-01-01

    目的:观察急性束缚应激和慢性束缚应激对小鼠情绪和学习记忆能力的影响.方法:小鼠按体重和自发活动随机分成三组,即空白对照组,急性应激组和慢性应激组.采用束缚躯体的方法建立急慢性应激模型,并用自发活动实验检测小鼠的情绪状态,避暗实验检测小鼠的学习记忆能力.结果:自发活动实验中急性束缚应激组小鼠平均速度与空白组相比有显著增加(P<0.01),中央区活动时间和中央区活动路程百分比则显著增加(P<0.05),慢性应激组平均速度与空白组相比有显著减小(P<0.01),中央区活动时间和中央区活动路程百分比显著减小(P<0.05);避暗测试中急性应激组避暗潜伏期和错误次数没有改变,而慢性应激组潜伏期显著减小(P<0.05)、错误次数急显著增加(P<0.01).结论:急性束缚应激会使小鼠产生烦躁情绪、但不会改变其学习记忆能力;慢性束缚应激会使小鼠产生抑郁样情绪,会损害其学习记忆能力.%Objective: To investigate the effects of acute restraint stress (ARS) and chronic restraint stress (CRS) on the emotional change and cognitive ebility of mice. Methods: Mice were divided to three groups according body weight and spontaneous activity state i. e. control group, ARS and CRS. Acute restraint stress and chronic restraint stress animal models were established and changes of emotional and cognitive performances were examined by open field and step-through tests. Results: In open field test, ARS group showed lower mean velocity (P <0.01) , time in central zone (P <0. 05) and the percentage of distance in zone/total (P <0. 05) , while CRS group significantly reduced ( P <0. 05). There is no change of step-through latency and number of mistakes in ARS group, however, step-through latency significantly increased (P<0. 01) and number of mistakes deceased in CRS group (P<0. 05). Conclusion:The present results suggested that

  16. Hypericum Perforatum L. Hypericaceae/Guttiferae Sunflower, Olive and Palm Oil Еxtracts Attenuate Cold Restraint Stress – Induced Gastric Lesions

    Directory of Open Access Journals (Sweden)

    Vanja Tadić

    2010-09-01

    Full Text Available Three Hypericum perforatum L., Hypericaceae (St. John’s Wort oil extracts (HPE were prepared according to the prescriptions from traditional medicine – fresh flowering tops were macerated in three different vegetable oils: sunflower (E1, olive (E2 and palm oil (E3 for 40 days, exposed to the sunlight. The aim of the study was to investigate the gastroprotective activity of the obtained extracts in respect to their quercetin content. HPLC analysis confirmed the presence of quercetin in all of the investigated HPEs, but in different amounts: 15.1, 5.8 and 21.7 μg/mL in E1, E2, and E3, respectively. Gastroprotective activity was evaluated using cold-restraint stress (CRS induced rat gastric mucosa lesions test. All of the HPEs showed gastroprotective activity, which was close to that achieved by the one of the most studied anti-ulcer flavonoids, quercetin [percentages of inhibition of ulcer index (UI were 35, 62 and 40 % in E1, E2 and E3, respectively]. Contrary to the lowest quercetin content, HPE prepared with olive oil (E2 offered the highest protection against gastric damaging action of CRS. It may be assumed that this is due to other constituents of E2, which probably play an additional role in complex gastroprotective activity.

  17. The choice of fat-free vs. regular-fat fudge: the effects of liking for the alternative and the restraint status.

    Science.gov (United States)

    Tuorila, H; Kramer, F M; Engell, D

    2001-08-01

    Non-restrained and restrained American women (N=157) chose a portion of a fat-free or regular-fat hot fudge, to be eaten on a portion of fat-free or regular-fat (depending on the experimental condition) ice cream. The subjects had tasted and rated samples of both fudge and ice cream earlier in the same session and, prior to the choice, they were informed of their own hedonic ratings of both fudges and of the respective fat contents ("fat-free" vs. "regular-fat"). The higher the hedonic difference (fat-free minus regular-fat) between hot fudge samples and the higher the individual restraint score, the more likely was the choice of the fat-free option. Also, the less hungry the subjects were prior to testing, the more likely they were to choose the fat-free version. On average, the hedonic difference between the hot fudge samples was roughly -0.5 for those choosing the fat-free option, while the corresponding value for subjects choosing the regular-fat version was -3 (9-point scale). The type of ice cream did not affect the choice. The data demonstrate the effects of a food (its hedonic quality), person (restrained status), and context (perceived hunger) on food choice. PMID:11562155

  18. Changes in the profile of NO synthases affect coronary blood flow autoregulation and myocardial contractile activity during restraint stress in rats.

    Science.gov (United States)

    Solodkov, A P; Lazuko, S S; Knyazev, E N; Nechaev, I N; Krainova, N A

    2014-12-01

    The efficiency of autoregulation of the coronary blood flow and contractile activity of the myocardium in the presence of inhibitors of constitutive and inducible NO synthases was studied in rats exposed to 6-h restraint stress. Intracoronary administration of S-methylisothiourea (10 μmol/liter), but not L-NAME (60 μmol/liter) fully prevented post-stress increase in the volume coronary blood flow rate, intensity of heart perfusion, and reduction of ventricular developed pressure at all levels of perfusion pressure. Real-time PCR showed 6-fold increased expression of inducible NO-synthase mRNA in the heart tissue against the background of unchanged expression of neuronal and endothelial NO synthases and 2-3-fold elevated content of transcripts of stress-inducible genes Hspa1a and Hspbp1. It was shown that the hypotension of coronary vessels and reduced contractile function of the myocardium are related to NO production by inducible NO synthase in endotheliocytes of coronary vessels and cardiomyocytes. PMID:25430647

  19. Monetary policy and wage bargaining in the EMU: restrictive ECB policies, high unemployment, nominal wage restraint and inflation above the target

    Directory of Open Access Journals (Sweden)

    Eckhard Hein

    2002-09-01

    Full Text Available Assessing the effects of monetary policy and wage bargaining on employment andinflation in the European Monetary Union (EMU, the first step sees development of a Post-Keynesian competitive claims model of inflation with endogenous money. In this model the NAIRU is considered to be a short-run limit to employment enforced by independent and conservative central banks. In the long run, however, the NAIRU will follow actual unemployment and is therefore also dependent on the forces determining aggregate demand, including monetary policies. But the NAIRU may also be reduced through effectively co-ordinated wage bargaining, as has been shown by institutional political economists. Applying these considerations to the economic performance of the EMU, different scenarios determined by wage bargainingcoordination and the European Central Bank's (ECB monetary policies are developed. It is shown that the first phase of the EMU was dominated by uncoordinated wage bargaining across the EMU and an "anti-growth-bias" of theECB. Thus the euro area was plagued with nominal wage restraint, highunemployment and inflation above the ECB target. Economic performance will improve if the ECB abandons its asymmetric monetary strategy. This may be facilitated by a higher degree of effective wage bargaining co-ordination across the EMU.

  20. From the "Unwanted babies" event on Ethics and Ethical Restraint%从"弃婴"事件谈职业操守与节制伦理

    Institute of Scientific and Technical Information of China (English)

    孙荫众; 高朋

    2011-01-01

    "Unwanted babies" incident in addition to directly reflect the absence of hospital management and loopholes, the act of disposal from the staff should be reduced to an even higher level of people's professional ethics, in particular the behavior of repeatedly breaking the bottom line will lead to medical ethics bottom line of ethics of social chaos and collapse.So the bottom line of ethics of the medical profession - not to harm the principle of self-discipline of medical workers is the basic requirement for the ethical standards of self-restraint.%"弃婴"事件除了直接反映医院管理的缺位和漏洞外,从工作人员处置行径的更深层次上还要归结为当事人的职业道德问题.医疗行业的底线伦理--不伤害原则,既是医务工作者自律精神的基本要求,也是节制自我的伦理标准.